Table S2. Differentially expressed miRNAs in between DN and sham groups. geneID Sham-Expression DN-Expression Sham-TPM DN-TPM log2 Ratio(DN/Sham) Up-Down-Regulation(DN/Sham) P-value FDR mmu-miR-466k 1 19 0.161799364 2.502970301 3.951363329 Up 0.000133695 0.001144163 mmu-miR-490-5p 1 15 0.161799364 1.976029185 3.610326411 Up 0.00118776 0.008371088 mmu-miR-6938-3p 1 14 0.161799364 1.844293906 3.510790737 Up 0.00203666 0.013014257 mmu-miR-3061-3p 1 13 0.161799364 1.712558627 3.403875533 Up 0.0034805 0.020785416 mmu-miR-3471 1 13 0.161799364 1.712558627 3.403875533 Up 0.0034805 0.020720865 mmu-miR-7219-3p 1 11 0.161799364 1.449088069 3.162867434 Up 0.01004406 0.049753134 mmu-miR-677-5p 3 30 0.485398093 3.95205837 3.02536391 Up 1.16E-05 0.000121133 mmu-miR-1950 1 10 0.161799364 1.31735279 3.02536391 Up 0.01694158 0.075178261 mmu-miR-6949-5p 1 10 0.161799364 1.31735279 3.02536391 Up 0.01694158 0.075004639 mmu-miR-7043-5p 1 10 0.161799364 1.31735279 3.02536391 Up 0.01694158 0.074831818 mmu-miR-3063-3p 1 10 0.161799364 1.31735279 3.02536391 Up 0.01694158 0.07465979 mmu-miR-3108-5p 1 10 0.161799364 1.31735279 3.02536391 Up 0.01694158 0.074488552 mmu-miR-122-5p 14 128 2.2651911 16.86211571 2.896080893 Up 1.17E-19 2.84E-18 mmu-miR-130c 4 36 0.647197457 4.742470044 2.873360817 Up 2.52E-06 2.84E-05 mmu-miR-488-5p 1 9 0.161799364 1.185617511 2.873360817 Up 0.0284124 0.112071133 mmu-miR-692 1 9 0.161799364 1.185617511 2.873360817 Up 0.0284124 0.111841008 mmu-miR-6990-3p 1 8 0.161799364 1.053882232 2.703435815 Up 0.0473316 0.166485646 mmu-miR-7650-5p 2 16 0.323598729 2.107764464 2.703435815 Up 0.00315688 0.019273054 mmu-miR-7211-5p 1 8 0.161799364 1.053882232 2.703435815 Up 0.0473316 0.166180727 mmu-miR-7013-3p 2 16 0.323598729 2.107764464 2.703435815 Up 0.00315688 0.01921187 mmu-miR-669l-5p 1 8 0.161799364 1.053882232 2.703435815 Up 0.0473316 0.165876924 mmu-miR-290a-5p 1 8 0.161799364 1.053882232 2.703435815 Up 0.0473316 0.165574228 mmu-miR-7066-3p 1 8 0.161799364 1.053882232 2.703435815 Up 0.0473316 0.165272636 mmu-let-7c-1-3p 3 20 0.485398093 2.63470558 2.440401409 Up 0.001603342 0.010860801 mmu-miR-196b-3p 2 13 0.323598729 1.712558627 2.403875533 Up 0.01358744 0.063840986 mmu-miR-34a-5p 437 2695 70.70632218 355.0265769 2.328015903 Up 8.98E-302 1.72E-299 mmu-miR-6405 2 12 0.323598729 1.580823348 2.288398316 Up 0.0218168 0.091117224 mmu-miR-153-3p 7 42 1.13259555 5.532881718 2.288398316 Up 6.79E-06 7.27E-05 mmu-miR-706 5 29 0.808996821 3.820323091 2.239488715 Up 0.00025267 0.002052408 mmu-miR-467d-5p 3 17 0.485398093 2.239499743 2.205936156 Up 0.00646564 0.034621877 mmu-miR-6932-3p 3 17 0.485398093 2.239499743 2.205936156 Up 0.00646564 0.034525437 mmu-miR-7239-3p 2 11 0.323598729 1.449088069 2.162867434 Up 0.0347564 0.130387512 mmu-miR-7074-5p 2 11 0.323598729 1.449088069 2.162867434 Up 0.0347564 0.130132849 mmu-miR-7038-5p 3 16 0.485398093 2.107764464 2.118473315 Up 0.01016704 0.049974912 mmu-miR-7024-3p 3 16 0.485398093 2.107764464 2.118473315 Up 0.01016704 0.049847099 mmu-miR-5623-5p 3 15 0.485398093 1.976029185 2.02536391 Up 0.01587498 0.071270109 mmu-miR-7029-3p 7 34 1.13259555 4.478999486 1.983543734 Up 0.000226186 0.001852985 mmu-miR-7677-5p 3 14 0.485398093 1.844293906 1.925828237 Up 0.0245954 0.100317834 mmu-miR-301a-3p 3 14 0.485398093 1.844293906 1.925828237 Up 0.0245954 0.100104845 mmu-miR-7089-3p 3 14 0.485398093 1.844293906 1.925828237 Up 0.0245954 0.099892758 mmu-miR-329-3p 5 23 0.808996821 3.029911417 1.905069676 Up 0.00347462 0.020815145 mmu-miR-493-5p 4 17 0.647197457 2.239499743 1.790898656 Up 0.0171767 0.075349505 mmu-miR-7062-3p 4 17 0.647197457 2.239499743 1.790898656 Up 0.0171767 0.075177475 mmu-miR-6348 5 21 0.808996821 2.766440859 1.773825143 Up 0.00796334 0.041482942 mmu-miR-212-5p 19 76 3.074187921 10.0118812 1.703435815 Up 4.67E-07 5.74E-06 mmu-miR-8114 5 20 0.808996821 2.63470558 1.703435815 Up 0.01193428 0.057338383 mmu-miR-7043-3p 18 70 2.912388557 9.221469531 1.662793831 Up 2.03E-06 2.32E-05 mmu-miR-7684-5p 5 19 0.808996821 2.502970301 1.629435234 Up 0.01775308 0.077171552 mmu-miR-7015-3p 9 34 1.456194278 4.478999486 1.620973655 Up 0.001304424 0.009093021 mmu-miR-467b-5p 9 34 1.456194278 4.478999486 1.620973655 Up 0.001304424 0.009060075 mmu-miR-465c-5p 7 26 1.13259555 3.425117254 1.596520611 Up 0.00573814 0.031161514 mmu-miR-7027-5p 9 33 1.456194278 4.347264207 1.577904933 Up 0.001903148 0.012451654 mmu-miR-132-5p 161 580 26.04969765 76.40646183 1.552428027 Up 1.84E-39 6.92E-38 mmu-miR-547-3p 5 18 0.808996821 2.371235022 1.551432722 Up 0.0261984 0.10462986 mmu-miR-7670-3p 7 25 1.13259555 3.293381975 1.539937083 Up 0.00838104 0.042958432 mmu-miR-9-3p 11 39 1.779793007 5.137675881 1.529406415 Up 0.000927522 0.0066594 mmu-miR-669a-5p 22 76 3.559586014 10.0118812 1.49193171 Up 4.60E-06 5.07E-05 mmu-miR-223-5p 60 205 9.707961855 27.0057322 1.476025319 Up 5.77E-14 1.10E-12 mmu-miR-6991-3p 5 17 0.808996821 2.239499743 1.468970562 Up 0.0383282 0.139421555 mmu-miR-7000-5p 5 17 0.808996821 2.239499743 1.468970562 Up 0.0383282 0.139157499 mmu-miR-511-5p 6 20 0.970796186 2.63470558 1.440401409 Up 0.0258326 0.103817808 mmu-miR-206-3p 10 33 1.617993643 4.347264207 1.42590184 Up 0.0039388 0.022950394 mmu-miR-5128 7 23 1.13259555 3.029911417 1.419642849 Up 0.01751326 0.07630209 mmu-miR-34b-3p 61 200 9.86976122 26.3470558 1.416554667 Up 6.16E-13 1.09E-11 mmu-miR-758-3p 6 19 0.970796186 2.502970301 1.366400828 Up 0.037149 0.135905788 mmu-miR-342-5p 7 22 1.13259555 2.898176138 1.355512512 Up 0.025034 0.10145915 mmu-miR-34c-5p 1377 4318 222.7977246 568.8329348 1.352270499 Up 2.43E-230 3.33E-228 mmu-miR-1191a 13 40 2.103391735 5.26941116 1.324924192 Up 0.00257242 0.016221477 mmu-miR-204-3p 29 89 4.692181563 11.72443983 1.321188251 Up 5.81E-06 6.29E-05 mmu-miR-337-3p 87 266 14.07654469 35.04158422 1.315774755 Up 3.97E-15 8.19E-14 mmu-miR-106a-5p 19 57 3.074187921 7.508910904 1.288398316 Up 0.000397368 0.003121944 mmu-miR-3572-3p 16 48 2.588789828 6.323293393 1.288398316 Up 0.001185678 0.00838725 mmu-miR-21a-5p 42467 125386 6871.133602 16517.75969 1.265397987 Up 0 0 mmu-miR-1933-3p 9 26 1.456194278 3.425117254 1.233950532 Up 0.0227352 0.093526563 mmu-miR-6900-3p 8 23 1.294394914 3.029911417 1.226997771 Up 0.0335766 0.12695531 mmu-miR-489-3p 7 20 1.13259555 2.63470558 1.218008988 Up 0.049892 0.172019719 mmu-miR-127-5p 7 20 1.13259555 2.63470558 1.218008988 Up 0.049892 0.171710887 mmu-miR-6923-5p 16 45 2.588789828 5.928087555 1.195288912 Up 0.00309582 0.018960661 mmu-miR-881-3p 179 496 28.9620862 65.34069839 1.173816348 Up 8.60E-23 2.29E-21 mmu-miR-21a-3p 33 91 5.339379021 11.98791039 1.166836336 Up 3.16E-05 0.00030133 mmu-miR-6919-5p 8 22 1.294394914 2.898176138 1.162867434 Up 0.0466562 0.165323356 mmu-miR-6906-5p 11 30 1.779793007 3.95205837 1.150894792 Up 0.020084 0.085748392 mmu-miR-129-1-3p 14 38 2.2651911 5.005940602 1.144008407 Up 0.00885742 0.044801251 mmu-miR-434-3p 30 81 4.853980928 10.6705576 1.136395223 Up 0.000122639 0.001063796 mmu-miR-499-5p 17 45 2.750589192 5.928087555 1.10782607 Up 0.00536096 0.029702197 mmu-miR-19a-3p 27 71 4.368582835 9.35320481 1.098295433 Up 0.000475078 0.003613986 mmu-miR-871-3p 21 55 3.397786649 7.245440346 1.092478106 Up 0.0022645 0.014374326 mmu-miR-3544-5p 102 263 16.50353515 34.64637838 1.069929463 Up 3.23E-11 5.39E-10 mmu-miR-217-5p 23 58 3.721385378 7.640646183 1.037854854 Up 0.00261554 0.016385589 mmu-miR-6897-5p 14 35 2.2651911 4.610734765 1.02536391 Up 0.0217078 0.09085994 mmu-miR-467d-3p 20 48 3.235987285 6.323293393 0.966470221 Up 0.01002204 0.04977267 mmu-let-7i-3p 18 43 2.912388557 5.664616997 0.959775569 Up 0.01557052 0.070232204 mmu-miR-132-3p 268 624 43.36222962 82.2028141 0.922748844 Up 1.26E-19 3.01E-18 mmu-miR-802-5p 93 213 15.04734088 28.05961443 0.898986624 Up 2.35E-07 3.05E-06 mmu-miR-147-5p 17 38 2.750589192 5.005940602 0.863900487 Up 0.037839 0.137903732 mmu-miR-672-5p 71 157 11.48775486 20.6824388 0.848309445 Up 2.44E-05 0.000237566 mmu-miR-669p-5p 29 64 4.692181563 8.431057857 0.84545482 Up 0.00763722 0.040111098 mmu-miR-7093-3p 25 55 4.044984106 7.245440346 0.840939339 Up 0.01401266 0.065199683 mmu-miR-7004-5p 17 37 2.750589192 4.874205323 0.82542634 Up 0.0488488 0.16995127 mmu-miR-669o-3p 17 37 2.750589192 4.874205323 0.82542634 Up 0.0488488 0.169643387 mmu-miR-409-3p 19 41 3.074187921 5.401146439 0.813060306 Up 0.0402514 0.144227914 mmu-miR-7222-3p 53 114 8.575366306 15.01782181 0.808405375 Up 0.000571312 0.004244981 mmu-miR-96-5p 688 1474 111.3179626 194.1778013 0.80269187 Up 2.97E-35 1.00E-33 mmu-miR-142a-3p 426 910 68.92652917 119.8791039 0.79844893 Up 3.40E-22 8.82E-21 mmu-miR-142a-5p 207 433 33.4924684 57.04137581 0.768172072 Up 1.06E-10 1.73E-09 mmu-miR-7a-1-3p 89 185 14.40014342 24.37102662 0.759083845 Up 3.08E-05 0.000294804 mmu-miR-3074-1-3p 26 54 4.206783471 7.113705067 0.757883599 Up 0.0260424 0.10444201 mmu-miR-362-5p 25 51 4.044984106 6.71849923 0.732004967 Up 0.0360258 0.132048678 mmu-miR-1195 27 55 4.368582835 7.245440346 0.729908027 Up 0.0296812 0.11564809 mmu-miR-34c-3p 37 75 5.986576478 9.880145926 0.72280114 Up 0.01149844 0.05538319 mmu-miR-150-5p 189 379 30.58007984 49.92767075 0.707247429 Up 1.89E-08 2.62E-07 mmu-miR-130b-3p 24 48 3.883184742 6.323293393 0.703435815 Up 0.0497144 0.17233726 mmu-miR-669c-5p 36 72 5.824777113 9.484940089 0.703435815 Up 0.01565436 0.07044462 mmu-miR-350-3p 60 118 9.707961855 15.54476292 0.679188269 Up 0.00258464 0.016245098 mmu-miR-215-5p 47 92 7.60457012 12.11964567 0.67240892 Up 0.00848546 0.043377672 mmu-let-7f-2-3p 104 203 16.82713388 26.74226164 0.668332014 Up 9.32E-05 0.000834483 mmu-miR-146b-5p 414 807 66.9849368 106.3103702 0.666373721 Up 6.46E-15 1.30E-13 mmu-miR-6239 54 104 8.73716567 13.70046902 0.648988031 Up 0.00662904 0.035299638 mmu-miR-375-3p 741 1424 119.8933289 187.5910373 0.645839514 Up 7.03E-24 1.92E-22 mmu-miR-467c-5p 45 86 7.280971392 11.32923399 0.637847474 Up 0.01521784 0.07029542 mmu-miR-298-3p 31 59 5.015780292 7.772381462 0.631882554 Up 0.0471594 0.16649092 mmu-miR-223-3p 69 130 11.16415613 17.12558627 0.617279171 Up 0.00363974 0.021403011 mmu-miR-134-5p 43 81 6.957372663 10.6705576 0.617021063 Up 0.0222814 0.092653891 mmu-miR-7080-3p 39 73 6.310175206 9.616675368 0.607858155 Up 0.0324772 0.124269047 mmu-miR-6959-3p 143 267 23.13730909 35.1733195 0.60426041 Up 4.09E-05 0.000382577 mmu-miR-342-3p 134 250 21.68111481 32.93381975 0.603130909 Up 7.43E-05 0.000671936 mmu-miR-143-5p 87 161 14.07654469 21.20937992 0.591409198 Up 0.001818484 0.012020806 mmu-miR-700-3p 80 148 12.94394914 19.49682129 0.590961086 Up 0.0028226 0.017454594 mmu-miR-7664-3p 439 8 71.02992091 1.053882232 -6.074641314 Down 5.25E-139 4.58E-137 mmu-miR-6912-3p 57 2 9.222563763 0.263470558 -5.129454199 Down 7.29E-18 1.64E-16 mmu-miR-6941-5p 324 14 52.42299402 1.844293906 -4.829059266 Down 9.49E-93 6.27E-91 mmu-miR-7080-5p 165 9 26.6968951 1.185617511 -4.492961398 Down 5.89E-46 2.35E-44 mmu-miR-3100-5p 46 3 7.442770756 0.395205837 -4.23516364 Down 3.06E-13 5.49E-12 mmu-miR-7003-3p 13 1 2.103391735 0.131735279 -3.997003903 Down 0.000234518 0.001913068 mmu-miR-6987-3p 12 1 1.941592371 0.131735279 -3.881526685 Down 0.000489498 0.003708963 mmu-miR-6357 12 1 1.941592371 0.131735279 -3.881526685 Down 0.000489498 0.003694361 mmu-miR-5112 34 3 5.501178385 0.395205837 -3.799064525 Down 2.01E-09 2.94E-08 mmu-miR-7651-3p 20 2 3.235987285 0.263470558 -3.61849228 Down 8.17E-06 8.70E-05 mmu-miR-712-3p 19 2 3.074187921 0.263470558 -3.544491698 Down 1.67E-05 0.000166455 mmu-miR-6953-5p 19 2 3.074187921 0.263470558 -3.544491698 Down 1.67E-05 0.000165593 mmu-miR-592-3p 9 1 1.456194278 0.131735279 -3.466489186 Down 0.00431824 0.024710645 mmu-miR-8096 9 1 1.456194278 0.131735279 -3.466489186 Down 0.00431824 0.024637101 mmu-miR-128-2-5p 9 1 1.456194278 0.131735279 -3.466489186 Down 0.00431824 0.024563994 mmu-miR-7046-5p 9 1 1.456194278 0.131735279 -3.466489186 Down 0.00431824 0.02449132 mmu-miR-5622-3p 34 4 5.501178385 0.526941116 -3.384027026 Down 1.11E-08 1.57E-07 mmu-miR-7653-3p 8 1 1.294394914 0.131735279 -3.296564185 Down 0.00880726 0.044902972 mmu-miR-466m-3p 8 1 1.294394914 0.131735279 -3.296564185 Down 0.00880726 0.044783866 mmu-miR-7061-3p 8 1 1.294394914 0.131735279 -3.296564185 Down 0.00880726 0.04466539 mmu-miR-194-1-3p 15 2 2.426990464 0.263470558 -3.20345478 Down 0.000277128 0.002222822 mmu-miR-150-3p 22 3 3.559586014 0.395205837 -3.171033303 Down 9.59E-06 0.000100502 mmu-miR-6995-5p 29 4 4.692181563 0.526941116 -3.15454518 Down 3.47E-07 4.41E-06 mmu-miR-5129-5p 7 1 1.13259555 0.131735279 -3.103919107 Down 0.01780922 0.077240441 mmu-miR-5623-3p 7 1 1.13259555 0.131735279 -3.103919107 Down 0.01780922 0.077066083 mmu-miR-5107-3p 7 1 1.13259555 0.131735279 -3.103919107 Down 0.01780922 0.076892511 mmu-miR-3099-3p 7 1 1.13259555 0.131735279 -3.103919107 Down 0.01780922 0.076719719 mmu-miR-7224-5p 31 5 5.015780292 0.658676395 -2.9288324 Down 3.70E-07 4.64E-06 mmu-miR-465a-5p 6 1 0.970796186 0.131735279 -2.881526685 Down 0.0356382 0.133174326 mmu-miR-466d-5p 6 1 0.970796186 0.131735279 -2.881526685 Down 0.0356382 0.132915232 mmu-miR-495-5p 6 1 0.970796186 0.131735279 -2.881526685 Down 0.0356382 0.132657144 mmu-miR-6372 6 1 0.970796186 0.131735279 -2.881526685 Down 0.0356382 0.132400057 mmu-miR-6537-5p 6 1 0.970796186 0.131735279 -2.881526685 Down 0.0356382 0.132143964 mmu-miR-448-3p 36 6 5.824777113 0.790411674 -2.881526685 Down 5.23E-08 7.05E-07 mmu-miR-8102 17 3 2.750589192 0.395205837 -2.799064525 Down 0.000277018 0.002231275 mmu-miR-669e-5p 11 2 1.779793007 0.263470558 -2.755995803 Down 0.00418236 0.024295709 mmu-miR-344e-3p 11 2 1.779793007 0.263470558 -2.755995803 Down 0.00418236 0.024222309 mmu-miR-101b-5p 11 2 1.779793007 0.263470558 -2.755995803 Down 0.00418236 0.02414935 mmu-miR-468-5p 11 2 1.779793007 0.263470558 -2.755995803 Down 0.00418236 0.024076829 mmu-miR-7020-3p 10 2 1.617993643 0.263470558 -2.61849228 Down 0.0080698 0.041585502 mmu-miR-3066-3p 35 7 5.662977749 0.922146953 -2.61849228 Down 3.49E-07 4.40E-06 mmu-miR-6963-5p 14 3 2.2651911 0.395205837 -2.518956606 Down 0.001927138 0.012523131 mmu-miR-2861 177 38 28.63848747 5.005940602 -2.516242221 Down 1.28E-29 3.95E-28 mmu-miR-96-3p 23 5 3.721385378 0.658676395 -2.498198046 Down 6.39E-05 0.00058592 mmu-miR-129b-5p 9 2 1.456194278 0.263470558 -2.466489186 Down 0.01539902 0.070791178 mmu-miR-543-5p 9 2 1.456194278 0.263470558 -2.466489186 Down 0.01539902 0.070621821 mmu-miR-292a-5p 9 2 1.456194278 0.263470558 -2.466489186 Down 0.01539902 0.070453273 mmu-miR-6973a-5p 9 2 1.456194278 0.263470558 -2.466489186 Down 0.01539902 0.070285527 mmu-miR-7218-3p 18 4 2.912388557 0.526941116 -2.466489186 Down 0.000473796 0.003633068 mmu-miR-3109-3p 18 4 2.912388557 0.526941116 -2.466489186 Down 0.000473796 0.003618593 mmu-miR-654-5p 40 9 6.47197457 1.185617511 -2.448567278 Down 1.54E-07 2.03E-06 mmu-miR-6932-5p 57 13 9.222563763 1.712558627 -2.429014481 Down 4.03E-10 6.23E-09 mmu-miR-7003-5p 13 3 2.103391735 0.395205837 -2.412041402 Down 0.00361584 0.02139372 mmu-miR-1941-3p 13 3 2.103391735 0.395205837 -2.412041402 Down 0.00361584 0.021327893 mmu-miR-3960 527 122 85.26826496 16.07170404 -2.407485999 Down 1.06E-80 6.56E-79 mmu-miR-6991-5p 49 12 7.928168849 1.580823348 -2.326311528 Down 1.68E-08 2.36E-07 mmu-miR-7063-3p 12 3 1.941592371 0.395205837 -2.296564185 Down 0.00671454 0.035655881 mmu-miR-124-5p 12 3 1.941592371 0.395205837 -2.296564185 Down 0.00671454 0.035557384 mmu-miR-7061-5p 12 3 1.941592371 0.395205837 -2.296564185 Down 0.00671454 0.03545943 mmu-miR-3070-3p 152 38 24.59350337 5.005940602 -2.296564185 Down 3.78E-23 1.02E-21 mmu-miR-3084-5p 24 6 3.883184742 0.790411674 -2.296564185 Down 0.000100837 0.000890806 mmu-miR-5116 8 2 1.294394914 0.263470558 -2.296564185 Down 0.0290078 0.113950723 mmu-miR-154-3p 8 2 1.294394914 0.263470558 -2.296564185 Down 0.0290078 0.113717694 mmu-miR-1901 11 3 1.779793007 0.395205837 -2.171033303 Down 0.0123243 0.058479414 mmu-miR-6919-3p 11 3 1.779793007 0.395205837 -2.171033303 Down 0.0123243 0.05833502 mmu-miR-6977-5p 11 3 1.779793007 0.395205837 -2.171033303 Down 0.0123243 0.058191338 mmu-miR-7023-5p 22 6 3.559586014 0.790411674 -2.171033303 Down 0.000328656 0.002614247 mmu-miR-7648-3p 36 10 5.824777113 1.31735279 -2.144561091 Down 4.52E-06 5.01E-05 mmu-miR-7052-3p 18 5 2.912388557 0.658676395 -2.144561091 Down 0.001312496 0.00908323 mmu-miR-7008-5p 18 5 2.912388557 0.658676395 -2.144561091 Down 0.001312496 0.009050557 mmu-miR-1892 50 14 8.089968213 1.844293906 -2.133065452 Down 6.67E-08 8.94E-07 mmu-miR-711 39 11 6.310175206 1.449088069 -2.122534785 Down 2.08E-06 2.36E-05 mmu-miR-25-5p 21 6 3.397786649 0.790411674 -2.103919107 Down 0.00058656 0.00434145 mmu-miR-6936-3p 27 8 4.368582835 1.053882232 -2.051451687 Down 0.000118969 0.001046163 mmu-miR-6982-5p 27 8 4.368582835 1.053882232 -2.051451687 Down 0.000118969 0.001041386 mmu-miR-7071-3p 10 3 1.617993643 0.395205837 -2.033529779 Down 0.0223238 0.092629274 mmu-miR-743a-5p 10 3 1.617993643 0.395205837 -2.033529779 Down 0.0223238 0.092429211 mmu-miR-7012-5p 10 3 1.617993643 0.395205837 -2.033529779 Down 0.0223238 0.09223001 mmu-miR-6933-5p 10 3 1.617993643 0.395205837 -2.033529779 Down 0.0223238 0.092031666 mmu-miR-7036b-3p 46 14 7.442770756 1.844293906 -2.012771219 Down 6.20E-07 7.53E-06 mmu-miR-1899 13 4 2.103391735 0.526941116 -1.997003903 Down 0.00952634 0.047931742 mmu-miR-6969-3p 13 4 2.103391735 0.526941116 -1.997003903 Down 0.00952634 0.047806266 mmu-miR-3964 29 9 4.692181563 1.185617511 -1.984620178 Down 9.39E-05 0.000837178 mmu-miR-1964-5p 19 6 3.074187921 0.790411674 -1.959529197 Down 0.001820536 0.011993016 mmu-miR-1224-5p 22 7 3.559586014 0.922146953 -1.948640881 Down 0.000808186 0.005868532 mmu-miR-299a-5p 22 7 3.559586014 0.922146953 -1.948640881 Down 0.000808186 0.005846387 mmu-miR-1945 24 8 3.883184742 1.053882232 -1.881526685 Down 0.000622358 0.004588693 mmu-miR-7660-3p 9 3 1.456194278 0.395205837 -1.881526685 Down 0.0398298 0.144063635 mmu-miR-3101-5p 9 3 1.456194278 0.395205837 -1.881526685 Down 0.0398298 0.143792329 mmu-miR-6973b-5p 9 3 1.456194278 0.395205837 -1.881526685 Down 0.0398298 0.143522042 mmu-miR-6917-5p 9 3 1.456194278 0.395205837 -1.881526685 Down 0.0398298 0.14325277 mmu-miR-8119 17 6 2.750589192 0.790411674 -1.799064525 Down 0.00543268 0.029926573 mmu-miR-453 17 6 2.750589192 0.790411674 -1.799064525 Down 0.00543268 0.029840824 mmu-miR-7007-3p 17 6 2.750589192 0.790411674 -1.799064525 Down 0.00543268 0.029755564 mmu-miR-8099 86 31 13.91474533 4.083793649 -1.768632629 Down 3.86E-10 6.01E-09 mmu-miR-7649-3p 11 4 1.779793007 0.526941116 -1.755995803 Down 0.0291536 0.114056023 mmu-miR-7666-5p 22 8 3.559586014 1.053882232 -1.755995803 Down 0.001799366 0.011935587 mmu-miR-652-5p 54 20 8.73716567 2.63470558 -1.729523592 Down 1.10E-06 1.30E-05 mmu-miR-7088-5p 32 12 5.177579656 1.580823348 -1.711601684 Down 0.000205926 0.001701552 mmu-miR-3966 655 246 105.9785836 32.40687864 -1.709400776 Down 3.81E-64 1.97E-62 mmu-miR-7010-5p 29 11 4.692181563 1.449088069 -1.695113561 Down 0.000454324 0.003511851 mmu-miR-296-5p 26 10 4.206783471 1.31735279 -1.675075808 Down 0.001006108 0.007169922 mmu-miR-205-3p 13 5 2.103391735 0.658676395 -1.675075808 Down 0.0212546 0.089746846 mmu-miR-7045-3p 13 5 2.103391735 0.658676395 -1.675075808 Down 0.0212546 0.0895496 mmu-miR-681 166 64 26.85869447 8.431057857 -1.671603616 Down 5.89E-17 1.28E-15 mmu-miR-181a-2-3p 140 54 22.651911 7.113705067 -1.6709597 Down 1.59E-14 3.15E-13 mmu-miR-1958 18 7 2.912388557 0.922146953 -1.659134264 Down 0.00680182 0.035821673 mmu-miR-3098-5p 23 9 3.721385378 1.185617511 -1.650201139 Down 0.00223806 0.014253691 mmu-miR-6942-5p 63 25 10.19335995 3.293381975 -1.629987918 Down 4.44E-07 5.53E-06 mmu-miR-6386 15 6 2.426990464 0.790411674 -1.61849228 Down 0.015478 0.070144979 mmu-miR-7677-3p 15 6 2.426990464 0.790411674 -1.61849228 Down 0.015478 0.069979542 mmu-miR-3067-3p 10 4 1.617993643 0.526941116 -1.61849228 Down 0.0498224 0.172399893 mmu-miR-3473g 10 4 1.617993643 0.526941116 -1.61849228 Down 0.0498224 0.172089263 mmu-miR-7028-3p 32 13 5.177579656 1.712558627 -1.596124467 Down 0.000414488 0.003229974 mmu-miR-5114 27 11 4.368582835 1.449088069 -1.592020068 Down 0.001226708 0.008613917 mmu-miR-6974-3p 27 11 4.368582835 1.449088069 -1.592020068 Down 0.001226708 0.008582479 mmu-miR-3154 61 25 9.86976122 3.293381975 -1.583445333 Down 1.15E-06 1.35E-05 mmu-miR-7224-3p 17 7 2.750589192 0.922146953 -1.576672104 Down 0.01127248 0.054569051 mmu-miR-3057-3p 12 5 1.941592371 0.658676395 -1.559598591 Down 0.0356584 0.131963615 mmu-miR-543-3p 12 5 1.941592371 0.658676395 -1.559598591 Down 0.0356584 0.13170935 mmu-miR-184-5p 12 5 1.941592371 0.658676395 -1.559598591 Down 0.0356584 0.131456063 mmu-miR-3473c 12 5 1.941592371 0.658676395 -1.559598591 Down 0.0356584 0.131203748 mmu-miR-191-3p 55 23 8.898965034 3.029911417 -1.554361942 Down 5.26E-06 5.76E-05 mmu-miR-7045-5p 31 13 5.015780292 1.712558627 -1.550320777 Down 0.000670634 0.004888233 mmu-miR-1231-3p 19 8 3.074187921 1.053882232 -1.544491698 Down 0.00821504 0.04222046 mmu-miR-6240 40 17 6.47197457 2.239499743 -1.531029438 Down 0.000125724 0.00108564 mmu-miR-7240-5p 282 120 45.62742072 15.80823348 -1.529224942 Down 1.55E-24 4.30E-23 mmu-miR-6907-5p 21 9 3.397786649 1.185617511 -1.518956606 Down 0.00599234 0.032267741 mmu-miR-6924-5p 14 6 2.2651911 0.790411674 -1.518956606 Down 0.0256062 0.103124129 mmu-miR-7053-5p 72 31 11.64955423 4.083793649 -1.512292876 Down 3.20E-07 4.12E-06 mmu-miR-7067-5p 72 31 11.64955423 4.083793649 -1.512292876 Down 3.20E-07 4.09E-06 mmu-miR-483-5p 128 56 20.71031863 7.377175625 -1.489209263 Down 1.52E-11 2.55E-10 mmu-miR-7056-3p 16 7 2.588789828 0.922146953 -1.489209263 Down 0.0184446 0.079101338 mmu-miR-7662-5p 25 11 4.044984106 1.449088069 -1.480988756 Down 0.00319806 0.019400889 mmu-miR-6954-3p 20 9 3.235987285 1.185617511 -1.448567278 Down 0.00964688 0.048284775 mmu-miR-7673-3p 20 9 3.235987285 1.185617511 -1.448567278 Down 0.00964688 0.048159034 mmu-miR-3077-5p 42 19 6.795573299 2.502970301 -1.440954094 Down 0.000172127 0.001434644 mmu-miR-7662-3p 26 12 4.206783471 1.580823348 -1.412041402 Down 0.00370696 0.021731628 mmu-miR-3620-3p 41 19 6.633773935 2.502970301 -1.406188676 Down 0.000269014 0.002175949 mmu-miR-208a-5p 240 112 38.83184742 14.75435125 -1.396099858 Down 1.32E-18 3.02E-17 mmu-miR-713 15 7 2.426990464 0.922146953 -1.396099858 Down 0.0297642 0.11573625 mmu-miR-6914-5p 15 7 2.426990464 0.922146953 -1.396099858 Down 0.0297642 0.115501966 mmu-miR-7672-3p 15 7 2.426990464 0.922146953 -1.396099858 Down 0.0297642 0.115268629 mmu-miR-3059-3p 15 7 2.426990464 0.922146953 -1.396099858 Down 0.0297642 0.115036233 mmu-miR-3078-3p 17 8 2.750589192 1.053882232 -1.384027026 Down 0.0213314 0.089676083 mmu-miR-344d-3p 19 9 3.074187921 1.185617511 -1.374566697 Down 0.01534686 0.070720987 mmu-miR-7020-5p 23 11 3.721385378 1.449088069 -1.360694522 Down 0.00801682 0.041535794 mmu-miR-5121 39 19 6.310175206 2.502970301 -1.33403889 Down 0.000643956 0.004711693 mmu-miR-188-5p 41 20 6.633773935 2.63470558 -1.332188094 Down 0.000472474 0.003637481 mmu-miR-3083-3p 16 8 2.588789828 1.053882232 -1.296564185 Down 0.0336854 0.127115968 mmu-miR-6351 28 14 4.530382199 1.844293906 -1.296564185 Down 0.00475558 0.026656277 mmu-miR-7238-5p 22 11 3.559586014 1.449088069 -1.296564185 Down 0.012489 0.058824111 mmu-miR-7034-5p 14 7 2.2651911 0.922146953 -1.296564185 Down 0.0473096 0.16671416 mmu-miR-470-5p 61 31 9.86976122 4.083793649 -1.273105212 Down 3.75E-05 0.000353695 mmu-miR-1968-5p 228 118 36.89025505 15.54476292 -1.24681115 Down 3.92E-15 8.16E-14 mmu-miR-5617-3p 23 12 3.721385378 1.580823348 -1.23516364 Down 0.01387094 0.064697304 mmu-miR-6399 51 27 8.251767577 3.556852533 -1.214102025 Down 0.00028416 0.002269728 mmu-miR-3475-5p 32 17 5.177579656 2.239499743 -1.209101344 Down 0.00423712 0.024319039 mmu-miR-8101 28 15 4.530382199 1.976029185 -1.197028511 Down 0.00799724 0.041546637 mmu-miR-1306-5p 26 14 4.206783471 1.844293906 -1.189648981 Down 0.01101792 0.053607494 mmu-miR-499-3p 63 34 10.19335995 4.478999486 -1.186381267 Down 7.41E-05 0.000672831 mmu-miR-3090-5p 33 18 5.339379021 2.371235022 -1.171033303 Down 0.00462588 0.0260818 mmu-miR-6974-5p 44 24 7.119172027 3.161646696 -1.171033303 Down 0.001060392 0.007528783 mmu-miR-7081-5p 100 55 16.17993643 7.245440346 -1.159060661 Down 9.34E-07 1.12E-05 mmu-miR-31-5p 38 21 6.148375842 2.766440859 -1.152174275 Down 0.0026848 0.016764696 mmu-miR-6977-3p 18 10 2.912388557 1.31735279 -1.144561091 Down 0.0407476 0.145462103 mmu-miR-1197-5p 18 10 2.912388557 1.31735279 -1.144561091 Down 0.0407476 0.145191727 mmu-miR-193b-5p 23 13 3.721385378 1.712558627 -1.119686423 Down 0.0228066 0.093619384 mmu-miR-671-5p 74 42 11.97315296 5.532881718 -1.113700128 Down 4.43E-05 0.000410671 mmu-miR-7044-5p 81 46 13.1057485 6.059822834 -1.112852232 Down 1.95E-05 0.000192758 mmu-miR-1199-5p 44 25 7.119172027 3.293381975 -1.112139614 Down 0.00168311 0.011242236 mmu-miR-2137 274 156 44.33302581 20.55070353 -1.109194049 Down 4.39E-15 8.95E-14 mmu-miR-6970-5p 35 20 5.662977749 2.63470558 -1.103919107 Down 0.00539498 0.029804544 mmu-miR-3073b-5p 265 155 42.87683153 20.41896825 -1.070288329 Down 6.81E-14 1.28E-12 mmu-miR-338-3p 46 27 7.442770756 3.556852533 -1.065238639 Down 0.001924048 0.012545578 mmu-miR-667-5p 332 196 53.71738893 25.82011469 -1.056893772 Down 1.04E-16 2.25E-15 mmu-miR-1967 22 13 3.559586014 1.712558627 -1.055556085 Down 0.033781 0.127226281 mmu-miR-224-5p 20 12 3.235987285 1.580823348 -1.033529779 Down 0.0467656 0.165405268 mmu-miR-7684-3p 43 26 6.957372663 3.425117254 -1.022389221 Down 0.00374216 0.0218711 mmu-miR-3100-3p 23 14 3.721385378 1.844293906 -1.012771219 Down 0.0358236 0.131559083 mmu-miR-675-5p 46 28 7.442770756 3.688587812 -1.012771219 Down 0.00292198 0.018011047 mmu-miR-3093-5p 98 60 15.8563377 7.904116741 -1.004383433 Down 1.56E-05 0.000158544 mmu-miR-1193-5p 98 60 15.8563377 7.904116741 -1.004383433 Down 1.56E-05 0.00015771 mmu-miR-27b-5p 78 48 12.62035041 6.323293393 -0.997003903 Down 0.000128645 0.001105885 mmu-miR-8098 34 21 5.501178385 2.766440859 -0.991709603 Down 0.01199784 0.057499648 mmu-miR-7009-5p 89 55 14.40014342 7.245440346 -0.990937902 Down 4.70E-05 0.000432934 mmu-miR-7648-5p 76 47 12.29675168 6.191558114 -0.989902847 Down 0.000171879 0.001438832 mmu-miR-3104-3p 249 154 40.2880417 20.28723297 -0.989779576 Down 9.97E-12 1.71E-10 mmu-miR-5129-3p 126 78 20.3867199 10.27535176 -0.988441889 Down 1.33E-06 1.55E-05 mmu-miR-5126 221 138 35.7576595 18.1794685 -0.975942287 Down 2.33E-10 3.67E-09 mmu-miR-208b-3p 70 44 11.3259555 5.796352276 -0.966415583 Down 0.00040939 0.003203268 mmu-miR-3073b-3p 68 43 11.00235677 5.664616997 -0.957762271 Down 0.000546446 0.004076019 mmu-miR-6979-3p 83 53 13.42934723 6.981969788 -0.943683162 Down 0.000161209 0.00135543 mmu-miR-7033-5p 25 16 4.044984106 2.107764464 -0.940420375 Down 0.0394738 0.143045888 mmu-miR-3067-5p 102 66 16.50353515 8.694528415 -0.924595407 Down 3.92E-05 0.000367938 mmu-miR-6912-5p 37 24 5.986576478 3.161646696 -0.92105505 Down 0.01370308 0.064070255 mmu-miR-1902 135 88 21.84291417 11.59270455 -0.913948163 Down 2.78E-06 3.12E-05 mmu-miR-5100 95 62 15.3709396 8.167587299 -0.912223483 Down 8.72E-05 0.000784829 mmu-miR-1251-3p 360 235 58.24777113 30.95779057 -0.911900335 Down 2.15E-14 4.21E-13 mmu-miR-540-5p 29 19 4.692181563 2.502970301 -0.906617666 Down 0.0313862 0.121061057 mmu-miR-6366 64 42 10.35515931 5.532881718 -0.904246762 Down 0.001397026 0.009564639 mmu-miR-5124a 59 39 9.546162491 5.137675881 -0.893805015 Down 0.00238464 0.01508698 mmu-miR-8105 123 82 19.9013218 10.80229288 -0.881526685 Down 1.44E-05 0.000148275 mmu-miR-7219-5p 158 106 25.56429955 13.96393958 -0.872424478 Down 1.09E-06 1.30E-05 mmu-miR-7017-5p 46 31 7.442770756 4.083793649 -0.86592983 Down 0.00905054 0.045657593 mmu-miR-6931-5p 31 21 5.015780292 2.766440859 -0.858443072 Down 0.0335528 0.127116043 mmu-miR-34a-3p 69 47 11.16415613 6.191558114 -0.85049979 Down 0.001633676 0.010988621 mmu-miR-7030-3p 348 238 56.30617876 31.3529964 -0.844689917 Down 1.95E-12 3.43E-11 mmu-miR-709 38 26 6.148375842 3.425117254 -0.84405198 Down 0.0203108 0.086524008 mmu-miR-7032-3p 38 26 6.148375842 3.425117254 -0.84405198 Down 0.0203108 0.086332159 mmu-miR-6414 146 100 23.62270718 13.1735279 -0.842532554 Down 5.43E-06 5.91E-05 mmu-miR-6915-5p 54 37 8.73716567 4.874205323 -0.841998321 Down 0.0057456 0.03102624 mmu-miR-5122 35 24 5.662977749 3.161646696 -0.840884701 Down 0.0264434 0.10517012 mmu-miR-105 42 29 6.795573299 3.820323091 -0.830900612 Down 0.01605898 0.071760057 mmu-miR-205-5p 95 66 15.3709396 8.694528415 -0.822025674 Down 0.000329908 0.002613362 mmu-miR-6948-3p 103 72 16.66533452 9.484940089 -0.81313971 Down 0.000212128 0.001745276 mmu-miR-673-5p 130 91 21.03391735 11.98791039 -0.811137358 Down 3.28E-05 0.000311383 mmu-miR-668-3p 75 53 12.13495232 6.981969788 -0.797462421 Down 0.001886086 0.012382284 mmu-miR-3101-3p 41 29 6.633773935 3.820323091 -0.796135194 Down 0.0218404 0.091017493 mmu-miR-181b-5p 1421 1007 229.9168966 132.657426 -0.793407056 Down 2.17E-41 8.34E-40 mmu-miR-195a-3p 1011 724 163.5791573 95.376342 -0.77828558 Down 5.22E-29 1.59E-27 mmu-miR-193a-3p 53 38 8.575366306 5.005940602 -0.776557126 Down 0.01069604 0.05230691 mmu-miR-7083-5p 78 56 12.62035041 7.377175625 -0.774611482 Down 0.00199784 0.012895149 mmu-miR-187-5p 72 52 11.64955423 6.850234509 -0.766049468 Down 0.00327468 0.01974076 mmu-miR-6966-3p 47 34 7.60457012 4.478999486 -0.763690195 Down 0.0178389 0.076675272 mmu-miR-15b-3p 155 113 25.07890146 14.88608653 -0.752509628 Down 2.14E-05 0.000209644 mmu-miR-1943-5p 52 38 8.413566941 5.005940602 -0.749076389 Down 0.01426466 0.066051578 mmu-miR-323-3p 86 63 13.91474533 8.299322578 -0.745549016 Down 0.00169398 0.011275554 mmu-miR-7220-3p 5449 4008 881.6447358 527.9949983 -0.739673167 Down 4.95E-136 3.95E-134 mmu-miR-1981-3p 174 128 28.15308938 16.86211571 -0.739507681 Down 9.23E-06 9.73E-05 mmu-miR-369-3p 836 621 135.2642685 81.80760827 -0.725473859 Down 1.19E-21 3.03E-20 mmu-miR-149-3p 47 35 7.60457012 4.610734765 -0.721870019 Down 0.0240846 0.098443877 mmu-miR-767 443 334 71.67711837 43.99958319 -0.704022781 Down 1.23E-11 2.08E-10 mmu-miR-341-3p 75 57 12.13495232 7.508910904 -0.692492861 Down 0.0059969 0.032201841 mmu-miR-486a-5p 2153 1637 348.3540312 215.6506517 -0.691858182 Down 5.37E-49 2.34E-47 mmu-miR-5124b 42 32 6.795573299 4.215528928 -0.688881608 Down 0.0406722 0.14546382 mmu-miR-27a-3p 24240 18470 3922.01659 2433.150603 -0.688770017 Down 0 0 mmu-miR-187-3p 9818 7482 1588.546158 985.6433576 -0.688569386 Down 7.34E-215 8.79E-213 mmu-miR-365-1-5p 47 36 7.60457012 4.742470044 -0.681228035 Down 0.032022 0.123018385 mmu-miR-151-5p 1543 1182 249.656419 155.7110998 -0.681072211 Down 1.12E-34 3.63E-33 mmu-miR-20b-5p 124 95 20.06312117 12.51485151 -0.680904887 Down 0.000499086 0.003751952 mmu-miR-7036a-5p 1125 864 182.0242848 113.8192811 -0.677385969 Down 1.67E-25 4.84E-24 mmu-miR-126b-5p 266 205 43.03863089 27.0057322 -0.672366521 Down 4.60E-07 5.69E-06 mmu-miR-101c 48 37 7.766369484 4.874205323 -0.67207332 Down 0.0322596 0.123683306 mmu-miR-664-3p 57 44 9.222563763 5.796352276 -0.67002258 Down 0.0199662 0.085435726 mmu-miR-486b-5p 2266 1755 366.6373594 231.1954147 -0.665241015 Down 3.89E-48 1.62E-46 mmu-miR-300-3p 104 81 16.82713388 10.6705576 -0.6571539 Down 0.00200464 0.012852491 mmu-miR-7663-3p 77 60 12.45855105 7.904116741 -0.65646013 Down 0.00790666 0.041412752 mmu-miR-29b-2-5p 78 61 12.62035041 8.03585202 -0.651229066 Down 0.00794672 0.041509161 mmu-miR-6380 46 36 7.442770756 4.742470044 -0.650201139 Down 0.04177 0.1482835 mmu-miR-5709-3p 74 58 11.97315296 7.640646183 -0.648036555 Down 0.0100486 0.049647336 mmu-miR-6981-5p 65 51 10.51695868 6.71849923 -0.646506656 Down 0.0160593 0.0715946 mmu-miR-455-5p 325 255 52.58479338 33.59249615 -0.646506656 Down 7.35E-08 9.79E-07 mmu-miR-6937-5p 213 168 34.46326459 22.13152687 -0.638956382 Down 1.62E-05 0.000162306 mmu-let-7b-3p 409 323 66.17593998 42.55049512 -0.637130863 Down 2.53E-09 3.67E-08 mmu-miR-486b-3p 115 91 18.60692689 11.98791039 -0.634259595 Down 0.001644134 0.011020297 mmu-miR-181a-1-3p 305 245 49.3488061 32.27514336 -0.612591678 Down 6.73E-07 8.11E-06 mmu-miR-181a-5p 5746 4624 929.699147 609.1439301 -0.60998078 Down 2.25E-102 1.60E-100 mmu-miR-6994-3p 4003 3232 647.6828551 425.7684218 -0.605218602 Down 6.45E-71 3.53E-69 mmu-miR-203-5p 156 126 25.24070082 16.59864516 -0.60468648 Down 0.000443106 0.003439005 mmu-miR-7663-5p 70 57 11.3259555 7.508910904 -0.592957188 Down 0.0207196 0.087874941 mmu-miR-718 513 418 83.00307386 55.06534663 -0.592020068 Down 4.12E-10 6.32E-09