Supplementary Table 1. Missense variants in voltage-gated sodium-channel gene transcripts and their population allele frequencies,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
CHROM,POS,REF,ALT,AC,exon,domestica_codon,AGAP004707-RA,AGAP004707-RB,AGAP004707-RC,Davies-C1N2,Davies-C3N2,Davies-C5N2,Davies-C7N2,Davies-C8N2,Davies-C10N2,Davies-C11N2,Davies-C1N9,Davies-C8N9,Davies-C1N9ck,AF_AOcol,AF_GHcol,AF_BFcol,AF_CIcol,AF_GNcol,AF_GW,AF_GM,AF_CMgam,AF_GHgam,AF_BFgam,AF_GNgam,AF_GAgam,AF_UGgam,AF_GQgam,AF_FRgam,AF_KE,FILTER_PASS,NoCoverage,LowCoverage,HighCoverage,LowMQ,HighMQ0,RepeatDUST,RepeatMasker,RepeatTRF,FS,HRun,QD,ReadPosRankSum
2L,2358254,G,A,1,1,E33,D33N,D33N,D33N,D33N,D33N,D33N,D33N,D33N,D33N,D33N,D33N,D33N,D33N,0,0,0,0,0,0,0,0.001683501683502,0,0,0,0,0,0,0,0,True,0,0,15,0,0,False,False,False,11.836,1,17.3,-0.022
2L,2359670,G,A,7,2j,,,,,,,,,E60K,,,,E60K,,0,0,0,0,0,0,0,0.01010101010101,0,0,0,0,0,0,0,0.010416666666667,False,1,271,1,1,0,False,False,False,5.78,6,14.13,-0.201
2L,2362002,A,T,3,3,,,,,D54V,D54V,D54V,D54V,D65V,D54V,D54V,D54V,D65V,D54V,0,0,0.02,0,0,0,0,0,0,0,0,0,0,0,0,0,True,0,1,3,0,0,False,False,False,6.375,0,13.59,-0.221
2L,2362019,G,T,3,3,G61,G54C,G54C,G54C,G60C,G60C,G60C,G60C,G71C,G60C,G60C,G60C,G71C,G60C,0,0,0.02,0,0,0,0,0,0,0,0,0,0,0,0,0,True,0,0,6,0,0,False,False,False,7.254,0,14.89,-0.303
2L,2362023,C,T,1,3,P62,P55L,P55L,P55L,P61L,P61L,P61L,P61L,P72L,P61L,P61L,P61L,P72L,P61L,0,0,0,0,0,0,0,0,0,0.005434782608696,0,0,0,0,0,0,True,0,1,4,0,0,False,False,False,0,0,13.4,-2.068
2L,2390168,A,G,2,7,K258,K251R,K251R,K251R,K257R,K214R,K257R,K257R,K268R,K257R,K257R,K257R,K268R,K257R,0,0,0,0,0,0,0,0,0,0,0,0.014492753623188,0,0,0,0,True,0,2,17,0,0,False,False,False,0,1,15.01,-0.057
2L,2390177,G,A,215,7,R261,R254K,R254K,R254K,R260K,R217K,R260K,R260K,R271K,R260K,R260K,R260K,R271K,R260K,0,0.009090909090909,0,0,0,0,0,0.313131313131313,0,0,0,0.202898550724638,0,0,0,0,True,0,4,13,0,0,False,False,False,0.479,1,19.5,1.877
2L,2390305,A,T,1,7,T304,T297S,T297S,T297S,T303S,T260S,T303S,T303S,T314S,T303S,T303S,T303S,T314S,T303S,0,0,0,0,0,0,0,0,0,0,0,0,0.004464285714286,0,0,0,True,0,1,18,0,0,False,False,False,15.07,0,10.16,1.525
2L,2390311,G,A,1,7,E306,E299K,E299K,E299K,E305K,E262K,E305K,E305K,E316K,E305K,E305K,E305K,E316K,E305K,0,0,0,0,0,0,0,0.001683501683502,0,0,0,0,0,0,0,0,True,0,1,15,0,0,False,False,False,0.922,3,12.84,-0.744
2L,2390448,G,A,6,8,G324,G317S,G317S,G317S,G323S,G280S,G323S,G323S,G334S,G323S,G323S,G323S,G334S,G323S,0,0,0,0,0,0,0,0.01010101010101,0,0,0,0,0,0,0,0,True,0,0,18,0,0,False,False,False,1.945,0,16.11,-0.958
2L,2391228,G,C,38,10,V410,V402L,V402L,V402L,V408L,V365L,,V408L,V419L,V408L,V408L,V408L,V419L,V408L,0,0.127272727272727,0.073333333333333,0.084507042253521,0.125,0,0,0,0,0,0,0,0,0,0,0,True,0,0,15,0,0,False,False,False,1.197,0,15.11,-1.264
2L,2391228,G,T,14,10,V410,V402L,V402L,V402L,V408L,V365L,,V408L,V419L,V408L,V408L,V408L,V419L,V408L,0,0.045454545454546,0.06,0,0,0,0,0,0,0,0,0,0,0,0,0,True,0,0,15,0,0,False,False,False,1.197,0,15.11,-1.264
2L,2399997,G,C,41,11i+,,D466H,D466H,D466H,D472H,D429H,D417H,D472H,D483H,D472H,D472H,D472H,D483H,D472H,0,0,0,0,0,0,0,0.069023569023569,0,0,0,0,0,0,0,0,True,0,2,11,0,0,False,False,False,13.234,0,15.47,0.066
2L,2400071,G,A,22,11i+,M508,M490I,M490I,M490I,M496I,M453I,M441I,M496I,M507I,M496I,M496I,M496I,M507I,M496I,0,0,0,0,0,0,0.030769230769231,0,0,0,0,0,0,0,0,0.1875,True,0,1,14,0,0,False,False,False,2.129,0,26.6,0.391
2L,2400071,G,T,2,11i+,M508,M490I,M490I,M490I,M496I,M453I,M441I,M496I,M507I,M496I,M496I,M496I,M507I,M496I,0,0,0,0,0,0,0,0.003367003367003,0,0,0,0,0,0,0,0,True,0,1,14,0,0,False,False,False,2.129,0,26.6,0.391
2L,2400076,T,A,3,11i+,I510,I492N,I492N,I492N,I498N,I455N,I443N,I498N,I509N,I498N,I498N,I498N,I509N,I498N,0,0,0,0,0,0,0,0,0,0,0,0,0.013392857142857,0,0,0,True,0,1,10,0,0,False,False,False,0,1,11.04,0.548
2L,2402466,G,T,2,13a,G549,G531V,G531V,G531V,G544V,,,,,,,G544V,,G544V,0,0,0,0,0,0,0,0,0,0,0,0.007246376811594,0,0.055555555555556,0,0,True,0,5,19,0,0,False,False,False,3.611,2,11.84,-0.651
2L,2402484,G,T,1,13a,R555,R537L,R537L,R537L,R550L,,,,,,,R550L,,R550L,0,0,0,0,0,0,0,0,0,0,0,0.007246376811594,0,0,0,0,True,0,6,17,0,0,False,False,False,2.977,1,14.68,-0.667
2L,2402508,A,T,2,13a,K563,Q545L,Q545L,Q545L,Q558L,,,,,,,Q558L,,Q558L,0,0,0,0,0,0,0,0,0,0.010869565217391,0,0,0,0,0,0,False,1,8,22,0,0,False,False,False,12.87,0,12.51,0.123
2L,2403206,G,A,2,14,A603,A586T,A586T,A586T,A599T,A528T,A516T,A571T,A582T,A571T,A571T,A599T,A582T,A599T,0,0,0,0,0,0,0,0.003367003367003,0,0,0,0,0,0,0,0,True,0,1,20,0,0,False,False,False,4.523,0,14.42,-0.305
2L,2407711,C,T,1,15,K662,R637C,R637C,R637C,R650C,R579C,R567C,R622C,R633C,R622C,R622C,R650C,R633C,R650C,0,0,0,0,0,0,0.007692307692308,0,0,0,0,0,0,0,0,0,True,0,3,11,0,0,False,False,False,1.33,0,14.45,1.002
2L,2407811,G,A,1,15,R697,R670Q,R670Q,R670Q,R683Q,R612Q,R600Q,R655Q,R666Q,R655Q,R655Q,R683Q,R666Q,R683Q,0,0,0,0,0,0.005494505494506,0,0,0,0,0,0,0,0,0,0,True,0,2,15,0,0,False,False,False,0.516,1,10.75,-0.09
2L,2407912,A,T,1,16,T706,T679S,T679S,T679S,T692S,T621S,T609S,T664S,T675S,T664S,T664S,T692S,T675S,T692S,0,0,0,0,0,0,0,0.001683501683502,0,0,0,0,0,0,0,0,True,0,3,12,0,0,False,False,False,0.801,1,22.1,0.184
2L,2407967,A,C,1,16,Q724,Q697P,Q697P,Q697P,Q710P,Q639P,Q627P,Q682P,Q693P,Q682P,Q682P,Q710P,Q693P,Q710P,0,0,0,0,0,0,0,0,0,0,0,0,0,0.055555555555556,0,0,True,0,3,16,0,0,False,False,False,8.58,1,11.65,-0.038
2L,2407987,A,G,1,16,M731,M704V,M704V,M704V,M717V,M646V,M634V,M689V,M700V,M689V,M689V,M717V,M700V,M717V,0,0,0.006666666666667,0,0,0,0,0,0,0,0,0,0,0,0,0,True,0,5,12,0,0,False,False,False,0,0,14.13,1.265
2L,2408125,C,A,1,17,A751,A724E,A724E,A724E,A737E,A666E,A654E,A709E,A720E,A709E,A709E,A737E,A720E,A737E,0,0,0,0,0,0,0,0.001683501683502,0,0,0,0,0,0,0,0,False,0,411,2,1,0,False,False,False,4.105,2,6.98,0.511
2L,2408136,G,A,1,17,G755,G728R,G728R,G728R,G741R,G670R,G658R,G713R,G724R,G713R,G713R,G741R,G724R,G741R,0.006410256410256,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,False,0,517,2,1,0,False,False,False,2.004,0,1.85,-2.371
2L,2416877,A,T,2,18b+,G776,M757L,M757L,M757L,M770L,M699L,M687L,M742L,M753L,M742L,M742L,M770L,M753L,M770L,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.041666666666667,0,True,0,0,19,0,0,False,False,False,1.706,1,8.94,1.197
2L,2416980,C,T,47,18b+,T810,T791M,T791M,T791M,T804M,T733M,T721M,T776M,T787M,T776M,T776M,T804M,T787M,T804M,0,0.009090909090909,0.02,0,0,0,0,0,0.291666666666667,0.146739130434783,0.1125,0,0,0,0,0,True,0,2,14,0,0,False,False,False,3.604,0,18.72,1.021
2L,2417206,A,C,1,19,I848,I829L,I829L,I829L,I842L,I771L,I759L,I814L,I825L,I814L,I814L,I842L,I825L,I842L,0,0,0,0,0,0,0,0.001683501683502,0,0,0,0,0,0,0,0,True,0,22,3,0,0,False,False,False,0,2,9.43,-0.314
2L,2417231,C,T,1,19,A856,A837V,A837V,A837V,A850V,A779V,A767V,A822V,A833V,A822V,A822V,A850V,A833V,A850V,0,0,0,0,0,0,0,0.001683501683502,0,0,0,0,0,0,0,0,True,0,54,1,0,0,False,False,False,4.168,0,13.61,-0.773
2L,2417772,A,T,1,20c,M944,M925L,,M925L,,,,,,,,,,M938L,0,0,0,0,0,0,0,0,0,0,0,0,0.004464285714286,0,0,0,True,0,2,16,0,0,False,False,False,9.95,1,16.1,0.301
2L,2421454,A,G,1,20d,,,M903V,,M916V,M845V,M833V,M888V,M899V,M888V,M888V,M916V,M899V,,0,0,0.006666666666667,0,0,0,0,0,0,0,0,0,0,0,0,0,True,0,1,17,0,0,False,False,False,4.434,1,13.93,0.475
2L,2421533,G,A,1,20d,,,G929E,,G942E,G871E,G859E,G914E,G925E,G914E,G914E,G942E,G925E,,0,0,0,0,0,0.005494505494506,0,0,0,0,0,0,0,0,0,0,True,0,1,14,0,0,False,False,False,5.336,3,12.04,-1.675
2L,2422486,C,A,1,21,K959,P940H,P940H,P940H,P953H,P882H,P870H,P925H,P936H,P925H,P925H,P953H,P936H,P953H,0,0,0,0,0,0,0,0,0,0.005434782608696,0,0,0,0,0,0,True,0,2,12,0,0,False,False,False,9.67,0,12.18,-1.595
2L,2422629,G,A,1,21,A1007,A988T,A988T,A988T,A1001T,A930T,A918T,A973T,A984T,A973T,A973T,A1001T,A984T,A1001T,0,0,0,0.007042253521127,0,0,0,0,0,0,0,0,0,0,0,0,True,0,5,13,0,0,False,False,False,0,0,17.38,-0.228
2L,2422651,T,C,483,21,L1014,L995S,L995S,L995S,L1008S,L937S,L925S,L980S,L991S,L980S,L980S,L1008S,L991S,L1008S,0,0,0,0,0,0,0,0.156565656565657,0,0,0,0.673913043478261,1,0,0,0.760416666666667,True,0,2,16,0,0,False,False,False,5.73,0,26.64,-0.86
2L,2422652,A,T,1131,21,L1014,L995F,L995F,L995F,L1008F,L937F,L925F,L980F,L991F,L980F,L980F,L1008F,L991F,L1008F,0.83974358974359,0.818181818181818,0.853333333333333,0.915492957746479,0.875,0,0,0.525252525252525,1,1,1,0.326086956521739,0,0,0,0,True,0,2,13,0,0,False,False,False,0.27,3,30.14,0.971
2L,2422833,T,A,1,22,K1056,S1037T,S1037T,S1037T,S1050T,S979T,S967T,S1022T,S1033T,S1022T,S1022T,S1050T,S1033T,S1050T,0,0,0,0,0,0.005494505494506,0,0,0,0,0,0,0,0,0,0,False,0,6,21,0,0,False,False,False,0.799,0,11.66,-0.516
2L,2422875,G,A,2,22,I1070,V1051I,V1051I,V1051I,V1064I,V993I,V981I,V1036I,V1047I,V1036I,V1036I,V1064I,V1047I,V1064I,0,0,0,0,0,0,0,0.003367003367003,0,0,0,0,0,0,0,0,False,0,7,24,0,0,False,False,False,9.734,0,16.38,-0.738
2L,2424284,G,A,1,23f+,D1100,D1092N,D1092N,D1092N,D1105N,D1034N,D1012N,D1067N,D1088N,D1077N,D1077N,D1105N,D1088N,D1105N,0,0,0,0,0,0,0.007692307692308,0,0,0,0,0,0,0,0,0,True,0,1,15,0,0,False,False,False,2.47,1,13.25,-0.914
2L,2424383,G,T,3,23f+,K1133,A1125S,A1125S,A1125S,A1138S,A1067S,A1045S,A1100S,A1121S,A1110S,A1110S,A1138S,A1121S,A1138S,0,0,0,0,0,0.005494505494506,0.015384615384615,0,0,0,0,0,0,0,0,0,False,0,0,21,0,0,False,False,False,0.924,0,16.47,0.278
2L,2424384,C,T,13,23f+,K1133,A1125V,A1125V,A1125V,A1138V,A1067V,A1045V,A1100V,A1121V,A1110V,A1110V,A1138V,A1121V,A1138V,0.083333333333333,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,False,0,1,21,0,0,False,False,False,1.506,0,14.27,-1.782
2L,2424401,A,G,2,23f+,F1139,I1131V,I1131V,I1131V,I1144V,I1073V,I1051V,I1106V,I1127V,I1116V,I1116V,I1144V,I1127V,I1144V,0,0,0,0,0,0,0,0.001683501683502,0,0,0,0.007246376811594,0,0,0,0,False,0,1,21,0,0,False,False,False,3.125,0,14.72,-1.645
2L,2424720,T,G,13,24h+,S1167,S1160A,,,,,,,,,,S1173A,S1156A,S1173A,0.006410256410256,0,0.013333333333333,0,0,0.005494505494506,0,0.008417508417508,0,0.005434782608696,0,0.007246376811594,0,0,0.041666666666667,0,False,0,3,10,0,0,False,False,False,2664,1,0.17,3.543
2L,2425077,G,A,7,25,I1262,V1254I,V1228I,V1228I,V1241I,V1170I,V1148I,V1203I,V1224I,V1213I,V1213I,V1267I,V1250I,V1267I,0,0,0,0,0,0.038461538461539,0,0,0,0,0,0,0,0,0,0,True,0,0,19,0,0,False,False,False,1.586,0,13.64,-0.274
2L,2425291,T,C,1,26,V1311,V1303A,V1277A,V1277A,V1290A,V1219A,V1197A,V1252A,V1273A,V1262A,V1262A,V1316A,V1299A,V1316A,0,0,0,0,0,0,0,0,0,0.005434782608696,0,0,0,0,0,0,True,0,0,19,0,0,False,False,False,5.906,0,15.7,-0.381
2L,2425299,C,T,1,26,P1314,P1306S,P1280S,P1280S,P1293S,P1222S,P1200S,P1255S,P1276S,P1265S,P1265S,P1319S,P1302S,P1319S,0,0,0,0.007042253521127,0,0,0,0,0,0,0,0,0,0,0,0,False,0,1,22,0,0,False,False,False,4.105,2,16.52,1.263
2L,2425417,A,T,5,26,N1353,N1345I,N1319I,N1319I,N1332I,N1261I,N1239I,N1294I,N1315I,N1304I,N1304I,N1358I,N1341I,N1358I,0,0.009090909090909,0.026666666666667,0,0,0,0,0,0,0,0,0,0,0,0,0,True,0,1,16,0,0,False,False,False,0.309,1,14.24,-0.256
2L,2425876,G,T,1,27k,,,,,,,,,,,,,,R1405L,0,0.009090909090909,0,0,0,0,0,0,0,0,0,0,0,0,0,0,True,0,4,12,0,0,False,False,False,2.36,2,15.95,1.745
2L,2428015,C,T,1,27l,W1374,L1366F,L1340F,L1340F,L1353F,L1282F,L1260F,L1315F,L1336F,L1325F,L1325F,L1379F,L1362F,,0,0,0,0,0,0,0,0,0,0.005434782608696,0,0,0,0,0,0,True,0,3,15,0,0,False,False,False,0.611,3,13.68,-0.477
2L,2429556,G,A,1,30,,V1507I,V1481I,V1481I,V1491I,V1420I,V1398I,V1453I,V1474I,V1463I,V1463I,V1517I,V1500I,V1517I,0,0,0,0,0.125,0,0,0,0,0,0,0,0,0,0,0,True,0,5,16,0,0,False,False,False,2.482,0,14.21,-1.084
2L,2429617,T,C,52,30,I1532,I1527T,I1501T,I1501T,I1511T,I1440T,I1418T,I1473T,I1494T,I1483T,I1483T,I1537T,I1520T,I1537T,0,0.172727272727273,0.133333333333333,0.084507042253521,0.125,0,0,0,0,0,0,0,0,0,0,0,True,0,6,16,0,0,False,False,False,3.22,0,15.79,0.095
2L,2429622,T,C,1,30,F1534,F1529L,F1503L,F1503L,F1513L,F1442L,F1420L,F1475L,F1496L,F1485L,F1485L,F1539L,F1522L,F1539L,0,0,0,0,0,0,0,0,0,0,0,0,0.004464285714286,0,0,0,True,0,4,17,0,0,False,False,False,8.61,1,14.94,-0.284
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