Category Group Type Subtype_name Subtype req_domain_code Required_domains less_strict Alt_req Cannot_have Uniprot_human Uniprot_DroMel citation DOI Link IMMUNITY Effector Genes AMP Aerolysin Aerolysin Aerolysin IPR005830 Lacomel et al. 2021 10.1016/j.jip.2021.107570 https://www.sciencedirect.com/science/article/pii/S0022201121000379?via%3Dihub IMMUNITY Effector Genes AMP Big defensin Big defensin Defensin_big_dom IPR028060 Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ IMMUNITY Effector Genes AMP defensin defensin defensine IPR001542 Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ IMMUNITY Effector Genes AMP Epsilon toxin ETX/MTX-2 Aerolysin-like IPR004991 Lacomel et al. 2021 10.1016/j.jip.2021.107570 https://www.sciencedirect.com/science/article/pii/S0022201121000379?via%3Dihub IMMUNITY Effector Genes AMP Lipopolysaccharide-binding protein/Bactericidal/permeability-increasing protein LBP/BPI "Lipid-bd_serum_glycop_C, Lipid-bd_serum_glycop_N" "IPR001124,IPR017942" IPR030675 P17213 Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ IMMUNITY Effector Genes AMP Macins Macins Macin IPR029230 IPR038456 Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Effector Genes AMP MACPF domain containing protein (Perfoin-like) MACPF MACPF IPR020864 P14222 Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ IMMUNITY Effector Genes AMP Mucin Mucin SEA_dom IPR000082 IPR036364 "P15941,Q02817,Q02505,Q99102,Q9HC84,Q6W4X9,Q8TAX7" Buddenbor et al. 2017 10.1371/journal.pntd.0005984 https://www.ncbi.nlm.nih.gov/pubmed/29045404 IMMUNITY Effector Genes AMP Myticin Myticin Myticin_preproprotein IPR019631 Philipp et al. 2012 10.1371/journal.pone.0033091 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308963/ IMMUNITY Effector Genes Antioxidants Catalase CAT Catalase_core IPR011614 P04040 Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ IMMUNITY Effector Genes Antioxidants Glutaredoxin GRX Glutaredoxin IPR002109 "P35754,Q9NS18,O76003,Q86SX6" Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Effector Genes Antioxidants Glutathion S transferase GST "GST_C, GST_N" "IPR004046,IPR004045" IPR010987 "P08263,P09210,Q16772,O15217,P09488,P28161,P21266,Q03013,P46439,P09211,Q9Y2Q3,P30711" Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Effector Genes Antioxidants Glutathione peroxidase GPX GPX_CS IPR029760 IPR000889 "P07203,P18283,P22352,P36969,O75715,P59796,Q96SL4,Q8TED1" Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Effector Genes Antioxidants Glutathione reductase GSR "FAD/NAD-binding_dom,Pyr_nucl-diS_OxRdtase_dimer" "IPR023753,IPR004099,IPR006322" "IPR006322,IPR036188,IPR016156" P00390 Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Effector Genes Antioxidants Nucleoredoxin NXN TryX_NRX_thioredoxin_dom IPR045870 Q6DKJ4 Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Effector Genes Antioxidants Peroxidases PRX Haem_peroxidase_animal IPR019791 IPR037120 Q9VEG6 Buddenbor et al. 2017 10.1371/journal.pntd.0005984 https://www.ncbi.nlm.nih.gov/pubmed/29045404 IMMUNITY Effector Genes Antioxidants Peroxiredoxin PRDX AhpC/TSA IPR000866 "IPR013766,IPR019479" "Q06830,P32119,P30048,Q13162,P30044,P30041" Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Effector Genes Antioxidants Superoxide Dismutase (Cu/Zn) SOD SOD_Cu_Zn_dom IPR001424 "IPR019832,IPR019831" "P00441,P08294" Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ IMMUNITY Effector Genes Antioxidants Superoxide Dismutase (Mn/Fe) MnSOD "Mn/Fe_SOD_C,Mn/Fe_SOD_N" "IPR019832,IPR019831" P04179 Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Effector Genes Antioxidants thioredoxin domain-containing protein TRXDC Thioredoxin_domain IPR013766 P10599 Buddenbor et al. 2017 10.1371/journal.pntd.0005984 https://www.ncbi.nlm.nih.gov/pubmed/29045404 IMMUNITY Effector Genes Antiviral Apolipoprotein B Editing Complex 3 proteins APOBEC3 "CMP_dCMP_dom,APOBEC/CMP_deaminase_Zn-bd" "IPR002125,IPR016192" IPR040551 "Q96AK3,Q9HC16,Q8IUX4,Q6NTF7,Q9NRW3,Q9UH17,P31941" Goubau et al. 2013 10.1016/j.immuni.2013.05.007 https://www.sciencedirect.com/science/article/pii/S1074761313002045 IMMUNITY Effector Genes Antiviral Caveolin CAV Caveolin_CS IPR018361 IPR001612 Q03135 Green et al. 2015 10.1099/jgv.0.000244 https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.000244#tab2 IMMUNITY Effector Genes Antiviral Deoxynucleoside triphosphate triphosphohydrolase SAMHD SAMHD "SAM, HD_dom" "IPR001660,IPR006674" "IPR013761,IPR003607" Q9Y3Z3 Goubau et al. 2013 10.1016/j.immuni.2013.05.007 https://www.sciencedirect.com/science/article/pii/S1074761313002045 IMMUNITY Effector Genes Antiviral Double-stranded RNA-specific adenosine deaminase ADAR "A_deamin,ADAR1_DSRM_1,ADAR1_DSRM_3,dsRBD_dom,Z_dom" "IPR002466,IPR044456,IPR044457,IPR014720,IPR042371" "IPR002466,IPR014720,IPR042371" "P55265,P78563" Q9NII1 Lamers et al. 2019 10.3389/fimmu.2019.01763 https://www.frontiersin.org/articles/10.3389/fimmu.2019.01763/full IMMUNITY Effector Genes Antiviral Gilt Gilt Interferon-induced_GILT IPR004911 P13284 Green et al. 2016 10.1186/s13567-016-0356-7 https://pubmed.ncbi.nlm.nih.gov/27439510/ IMMUNITY Effector Genes Antiviral Interferon-induced GTP-binding protein Mx Mx "GED,Dynamin_GTPase,Dynamin_stalk,Dynamin_N" "IPR003130,IPR001401,IPR000375,IPR045063" "IPR020850,IPR030381,IPR027417" P20591 Green et al. 2015 10.1099/jgv.0.000244 https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.000244#tab2 IMMUNITY Effector Genes Antiviral Interferon-induced protein 44 IFI44 "TLDc_dom,P-loop_NTPase" "IPR006571,IPR027417" IPR024644 Q8TCB0 Green and Speck 2018 10.3390/v10030133 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869526/ IMMUNITY Effector Genes Antiviral Interferon-induced transmembrane protein-like IFITML CD225/Dispanin_fam IPR007593 "P13164,Q01629,Q01628,A6NNB3" Goubau et al. 2013 10.1016/j.immuni.2013.05.007 https://www.sciencedirect.com/science/article/pii/S1074761313002045 IMMUNITY Effector Genes Antiviral Protein mono-ADP-ribosyltransferase PARPs Poly(ADP-ribose)pol_cat_dom IPR012317 "P09874,Q9UGN5,Q9Y6F1,Q9UKK3,O95271,Q2NL67,Q7Z3E1,Q8N3A8,Q8IXQ6,Q53GL7,Q9NR21,Q9H0J9,Q3UPF5,Q460N5,Q460N3,Q8N5Y8" Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Effector Genes Antiviral Ribonuclease L RNASEL "Ankyrin_rpt, RNase-L_Rnase,Prot_kinase_dom" "IPR002110,IPR042745,IPR000719" "IPR036770,IPR010513,IPR011009" Q05823 Goubau et al. 2013 10.1016/j.immuni.2013.05.007 https://www.sciencedirect.com/science/article/pii/S1074761313002045 IMMUNITY Effector Genes Antiviral Tetherines (Bone marrow stromal antigen 2-like) BST2L BST2 IPR024886 Q10589 Goubau et al. 2013 10.1016/j.immuni.2013.05.007 https://www.sciencedirect.com/science/article/pii/S1074761313002045 IMMUNITY Effector Genes Antiviral Tripartite motif-containing protein 5 TRIM5 "SPRY,Znf-RING_LisH,Znf_B-box" "IPR003877,IPR027370,IPR000315" "IPR043136,IPR000315,IPR013083" Q9C035 Goubau et al. 2013 10.1016/j.immuni.2013.05.007 https://www.sciencedirect.com/science/article/pii/S1074761313002045 IMMUNITY Effector Genes Antiviral viperins (Radical S-adenosyl methionine domain-containing proteins) RSADs "rSAM,Aldolase_TIM" "IPR007197,IPR013785" "Q9HA92,Q8WXG1" Goubau et al. 2013 10.1016/j.immuni.2013.05.007 https://www.sciencedirect.com/science/article/pii/S1074761313002045 IMMUNITY Effector Genes Antiviral zinc finger NFX1-type containing 1 ZNFX1 "DNA2/NAM7_AAA_11,DNA2/NAM7-like_C,Znf_NFX1,ARM-type_fold" "IPR041677,IPR041679,IPR000967,IPR016024" "IPR045055,IPR041677,IPR041679" Q9P2E3 Blasi et al. 2022 10.1016/j.fsi.2022.01.019 https://www.sciencedirect.com/science/article/pii/S1050464822000286#appsec1 IMMUNITY Effector Genes Antiviral Zinc-finger antiviral proteins ZAP "Poly(ADP-ribose)pol_cat_dom, WWE-dom, ZAP_HTH,Znf-CCCH_8,Znf_CCCH" "IPR012317,IPR004170,IPR041360,IPR040954,IPR000571" "IPR004170,IPR041360,IPR040954,IPR000571" Q7Z2W4 Meagher et al. 2019 10.1073/pnas.1913232116 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883784/ IMMUNITY Effector Genes Autophagy Beclin Beclin "Atg6/beclin_CC,Atg6_BARA,BH3_dom" "IPR041691,IPR040455,IPR029318" IPR038274 Q14457 Green et al. 2016 10.1186/s13567-016-0356-7 https://pubmed.ncbi.nlm.nih.gov/27439510/ IMMUNITY Effector Genes Complement alpha-2-macroglobulin containing proteins A2M Macroglobln_a2 IPR001599 P01023 Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ IMMUNITY Effector Genes Complement C1q domain containing proteins C1qDC C1qD IPR001073 Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ IMMUNITY Effector Genes Complement Cluster of Differentiation 109 CD109 "A-macroglobulin_rcpt-bd,A2M_N_BRD,A2M_TED,Macroglobln_a2,MG2,MG3" "IPR009048,IPR011625,IPR041813,IPR013783,IPR001599,IPR002890,IPR041555" "IPR036595,IPR011626,IPR011625,IPR041813,IPR013783,IPR001599" "IPR010916,IPR040839" Q6YHK3 Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ IMMUNITY Effector Genes Complement Complement proteins 3/4/5 C3/4/5 "Netrin_domain,A-macroglobulin_rcpt-bd,Alpha-macroglobulin_TED" "IPR001134,IPR009048,IPR011626" "IPR008993,IPR036595" "P01024,P0C0L4,P0C0L5,P01031" Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ IMMUNITY Effector Genes Complement Factor B-like CFB "VWF_A,Sushi_SCR_CCP_dom,Trypsin_dom" "IPR002035,IPR000436,IPR001254" IPR011360 P00751 Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ IMMUNITY Effector Genes Complement Multiple epidermal growth factor-like domains protein 10 MEGF10 "EGF-like_Ca-bd_dom,EGF-like_dom,EMI_domain" "IPR001881,IPR000742,IPR011489" Q96KG7 Green et al. 2016 10.1186/s13567-016-0356-7 https://pubmed.ncbi.nlm.nih.gov/27439510/ IMMUNITY Effector Genes Complement thioester containing protein (thioester) TEP Alpha-macroglobulin_TED IPR011626 Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ REGULATORY PATHWAYS Effector Genes E3 Ubiquitin ligases Cullin CUL Cullin_homology IPR016158 IPR036317 Q13616 Li et al. 2022 10.1007/s00251-021-01236-3 https://pubmed.ncbi.nlm.nih.gov/34854945/ REGULATORY PATHWAYS Effector Genes E3 Ubiquitin ligases F-box/LRR-repeat protein FBXL "F-box_dom, LRR_dom_sf" "IPR001810,IPR032675" "IPR036047,IPR032675" "Q9UKC9,Q9UKT7" Li et al. 2022 10.1007/s00251-021-01236-3 https://pubmed.ncbi.nlm.nih.gov/34854945/ REGULATORY PATHWAYS Effector Genes E3 Ubiquitin ligases S-phase kinase-associated protein 1 SKIP1 "Skp1_comp_POZ,Skp1_comp_dimer" "IPR016073,IPR016072" "IPR011333,IPR036296" Q13616 Li et al. 2022 10.1007/s00251-021-01236-3 https://pubmed.ncbi.nlm.nih.gov/34854945/ REGULATORY PATHWAYS Effector Genes E3 Ubiquitin ligases Tumor necrosis factor alpha-induced protein 3/A20-like TNAP3/A20 "Znf_A20,OTU_dom" "IPR002653,IPR003323" IPR033478 P21580 Philipp et al. 2012 10.1371/journal.pone.0033091 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308963/ IMMUNITY Effector Genes Lysozyme Lysozyme Lysozyme Glyco_hydro_22_CS IPR019799 IPR023346 P61626 Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ IMMUNITY Effector Genes Metabolism Alcohol dehydrogenase-like ADH ADH-like_C IPR013149 "P07327,P00325,P00326,P08319,P40394,P11766" Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Effector Genes Metabolism Estrogen receptor/oestrogen-related receptors ERR "Nucl_hrmn_rcpt_lig-bd,Znf_hrmn_rcpt,Est_rcpt/est-rel_rcp" "IPR000536,IPR001628,IPR024178" IPR024178 "P11474,O95718" Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Effector Genes Metabolism Ferritins Ferritin Ferritin_DPS_dom IPR008331 IPR001519 "P02792,P02794" Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Effector Genes Metabolism Retinoid X receptor RXR "Retinoid-X_rcpt/HNF4,Znf_hrmn_rcpt,Nucl_hrmn_rcpt_lig-bd,Nuc_recep-AF1" "IPR000003,IPR001628,IPR000536,IPR021780" IPR000003 "P19793,P28704,P48443" Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Effector Genes Metabolism Serine/threonine-protein phosphatase PP1 PP1 "Ser/Thr-sp_prot-phosphatase,STPPase_N" "IPR006186,IPR031675" IPR037979 "P62136,P62140,P36873" Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Effector Genes Metabolism Ubiquitin-like proteins Ubiquitin-like Ubiquitin-like_dom IPR000626 Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Effector Genes Phenoloxidase/melanisation-type reaction Laccase Laccase "CuRO_1_LCC,CuRO_2_LCC" "IPR034288,IPR034285" IPR001117 Q8IV20 Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Effector Genes Phenoloxidase/melanisation-type reaction Phenoloxidase proPO "Hemocyanin/hexamerin_mid_dom,Hemocyanin_C,Hemocyanin_N,Tyrosinase_Cu-bd,Ig_E-set" "IPR000896,IPR005203,IPR005204,IPR002227,IPR014756" "IPR008922,IPR037020,IPR036697" "Q9V521,Q9W1V6" Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Effector Genes Phenoloxidase/melanisation-type reaction Tyrosinase Tyrosinase Tyrosinase_Cu-bd IPR002227 "P14679,P17643" Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Effector Genes RNAi Argonaute AGO "Argonaute_Mid_dom,Argonaute_N,PAZ_dom,Piwi,ArgoL1,ArgoL2" "IPR032473,IPR032474,IPR003100,IPR003165,IPR014811,IPR032472" "IPR003165,IPR036085,IPR032473" Q9UKV8 Green and Speck 2018 10.3390/v10030133 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869526/ IMMUNITY Effector Genes RNAi Dicer Dicer "DICER_DSRM,RNase_III_dom,PAZ_dom" "IPR044441,IPR000999,IPR003100" "IPR014720,IPR038248,IPR036085,IPR036389" Q9UPY3 Green and Speck 2018 10.3390/v10030133 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869526/ IMMUNITY Effector Genes RNAi Piwi-like PIWI "Piwi,ArgoL1,PAZ_dom" "IPR003165,IPR014811,IPR003100" IPR003165 Q96J94 Buddenbor et al. 2017 10.1371/journal.pntd.0005984 https://www.ncbi.nlm.nih.gov/pubmed/29045404 IMMUNITY Effector Genes RNAi RISC-loading complex subunit TARBP TRBP "TRBP2_DSRM_1,TRBP2_DSRM_2,TRBP2_DSRM_3" "IPR044469,IPR044470,IPR044471" "IPR014720,IPR028605" Q15633 Green et al. 2015 10.1099/jgv.0.000244 https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.000244#tab2 IMMUNITY Effector Genes ROS Dual oxidase DUOX "EF-hand-dom_pair, EF_hand_dom, FAD-bd_8, FAD-bd_FR_type, Fe3_Rdtase_TM_dom, FNR_nucleotide-bd, Haem_peroxidase_animal, Riboflavin_synthase-like_b-brl" "IPR011992,IPR002048,IPR013112,IPR017927,IPR013130,IPR039261,IPR019791,IPR017938" "Q9NRD9,Q9NRD8" Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Effector Genes ROS Dual oxidase maturation factor DUOXA Dual_oxidase_maturation_fac IPR018469 "Q1HG43,Q1HG44" Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Effector Genes ROS L-Amino Oxidase LAAO Amino_oxidase IPR002937 Q96RQ9 Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Effector Genes ROS NADPH oxidase NOX "FAD-bd_FR_type,Fe3_Rdtase_TM_dom,Fe_red_NAD-bd_6" "IPR017927,IPR013130,IPR013121" IPR000778 "Q9Y5S8,Q9HBY0,Q9NPH5" Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Effector Genes ROS Nitric-oxide synthase NOS "NOS_N,Flavodoxin/NO_synt" "IPR004030,IPR008254" IPR008254 "P29475,P35228,P29474" Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ IMMUNITY Effector Genes ROS Peroxidasin PRXDN Peroxidasin_peroxidase IPR034824 IPR029610 "Q92626,A1KZ92" Q9VZZ4 Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Effector Genes Stress responses Heat shock 20 kDa protein HSP20 A-crystallin/Hsp20_dom IPR002068 IPR008978 Green et al. 2016 10.1186/s13567-016-0356-7 https://pubmed.ncbi.nlm.nih.gov/27439510/ IMMUNITY Effector Genes Stress responses Heat shock 70 kDa protein HSP70 Heat_shock_70_CS IPR018181 IPR013126 "P0DMV8,P0DMV9,P34931" Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Effector Genes Stress responses Heat shock 90 kDa protein HSP90 "Heat_shock_protein_90_CS,Hsp90_N,HATPase_C" "IPR019805,IPR020575,IPR003594" IPR001404 "P07900,P08238" Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Effector Genes Stress responses Heat shock factor protein HSF "HATPase_C,HSF_DNA-bd" "IPR003594,IPR000232" IPR027725 "Q00613,Q03933" Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Immune receptor DExD/H-box helicases ATP-dependent RNA helicase DDX1 DDX1 "DEAD/DEAH_box,SPRY_dom,B30.2/SPRY" "IPR011545,IPR003877,IPR001870" "IPR011545,IPR027417,IPR043136" Q92499 Su et al. 2022 10.1007/s00018-021-04072-6 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671602/ IMMUNITY Immune receptor DExD/H-box helicases ATP-dependent RNA helicase DDX21 DDX21 "DEAD/DEAH_box,GUCT" "IPR011545,IPR012562" "IPR011545,IPR035979" Q9NR30 Su et al. 2023 10.1007/s00018-021-04072-6 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671602/ IMMUNITY Immune receptor DExD/H-box helicases ATP-dependent RNA helicase DDX41 DDX41 "DEAD/DEAH_box,DEADc_DDX41" "IPR011545,IPR044113" Q9UJV9 Su et al. 2027 10.1007/s00018-021-04072-6 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671602/ IMMUNITY Immune receptor DExD/H-box helicases ATP-dependent RNA helicase DHX15 DHX15 "DEAD/DEAH_box,DHX15_DEXHc" "IPR011545,IPR044756" O43143 Su et al. 2025 10.1007/s00018-021-04072-6 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671602/ IMMUNITY Immune receptor DExD/H-box helicases ATP-dependent RNA helicase DHX9 DHX9 "DEAD/DEAH_box,DHX9_DSRM_1,DHX9_DSRM_2" "IPR011545,IPR044445,IPR044446" "IPR011545,IPR014720" Q08211 Su et al. 2027 10.1007/s00018-021-04072-6 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671602/ IMMUNITY Immune receptor DExD/H-box helicases ATP-dependent RNA helicase with DEAD Q motif DDX_DEAD_Q "DEAD/DEAH_box,RNA_helicase_DEAD_Q_motif" "IPR011545,IPR014014" "O00148,Q13838,Q9UJV9,Q9NY93,Q9NY93,P26196,Q9BUQ8,Q9GZR7,O00571,O15523,Q92841,Q9NUU7,Q9UMR2" Su et al. 2024 10.1007/s00018-021-04072-6 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671602/ IMMUNITY Immune receptor DExD/H-box helicases ATP-dependent RNA helicases with Domain of unknown function 1605 DHX_DUF1605 "DEAD/DEAH_box,DUF1605" "IPR011545,IPR011709" "Q7L2E3,Q7Z478,Q9H2U1,Q9H6R0,Q7L2E3" Su et al. 2026 10.1007/s00018-021-04072-6 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671602/ IMMUNITY Immune receptor DExD/H-box helicases DExD/H-box helicases - other DExD/H-box DEAD/DEAH_box IPR011545 "IPR041204,IPR021673" Su et al. 2021 10.1007/s00018-021-04072-6 https://pubmed.ncbi.nlm.nih.gov/34910251/ IMMUNITY Immune receptor Gene associated with VDJ recombination RAG-like RAG-like C2H2 RAG1-type zinc finger IPR019485 "IPR018957,IPR035714" "P15918,P55895" Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ IMMUNITY Immune receptor lectins Apextrin Apextrin ApeC IPR031569 Gerdol 2017 10.25431/1824-307X/isj.v14i1.103-118 https://www.isj.unimore.it/index.php/ISJ/article/view/29/332 IMMUNITY Immune receptor lectins C-type lectin domain containing proteins CTLDC CTLD IPR001304 IPR016187 Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ IMMUNITY Immune receptor lectins Chitinases Chi-lectin Glyco_hydro18_cat IPR001223 Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Immune receptor lectins F-box domain containing lectins F-box lectins "F-box_dom,F-box-assoc_dom,Galactose-bd-like_sf" "IPR001810,IPR007397,IPR008979" Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Immune receptor lectins Fibrinogen domain containing protein FBGDC Fibrinogen_a/b/g_C_dom IPR002181 Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ IMMUNITY Immune receptor lectins Fucolectin F-type lectins FTP1 IPR006585 Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Immune receptor lectins Galectin domain containg proteins Galectin Gal_CRD IPR001079 Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ IMMUNITY Immune receptor lectins H-type lectins H-type lectin H-type_lectin_domain IPR019019 IPR037221 Gerdol 2017 10.25431/1824-307X/isj.v14i1.103-118 https://www.isj.unimore.it/index.php/ISJ/article/view/29/332 IMMUNITY Immune receptor lectins immunoglobulin lectins I-type lectins Ig_I-set IPR013098 Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Immune receptor lectins Legume-like lectin L-type lectin Lectin_leg IPR005052 Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Immune receptor lectins mannose 6-phosphate receptor homology domain containing P-type lectin MRH IPR044865 IPR009011 Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ IMMUNITY Immune receptor lectins Mannose-binding lectin MBP Collectin_CTLD IPR033990 P48740 Nauta et al. 2003 10.1002/eji.200323888 https://pubmed.ncbi.nlm.nih.gov/14515269/ IMMUNITY Immune receptor lectins Pentraxins Pentraxins Pentaxin_CS IPR030476 IPR001759 Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Immune receptor lectins Ricin-type lectins R-type lectins Ricin_B_lectin IPR000772 Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Immune receptor lectins SUEL lectins SUEL lectin Lectin_gal-bd_dom IPR000922 Gerdol 2017 10.25431/1824-307X/isj.v14i1.103-118 https://www.isj.unimore.it/index.php/ISJ/article/view/29/332 IMMUNITY Immune receptor lectins VIgL _C-type lectin-related protein CREP "CTLD, Ig-like" "IPR001304,IPR007110" "IPR001304,IPR036179" "IPR003961,IPR036116" Dheilly et al. 2015 10.1016/j.dci.2014.10.009 https://www.sciencedirect.com/science/article/pii/S0145305X14002560 IMMUNITY Immune receptor lectins VIgL _Galectin-related protein GREP "Galectin, Ig-like" "IPR001079,IPR007110" "IPR001079,IPR036179" Dheilly et al. 2015 10.1016/j.dci.2014.10.009 https://www.sciencedirect.com/science/article/pii/S0145305X14002560 IMMUNITY Immune receptor lectins VIgL_fibrinogen-related proteins FREP "Fibrinogen_a/b/g_C_dom, Ig-like" "IPR002181,IPR007110" "IPR002181,IPR036179" Dheilly et al. 2015 10.1016/j.dci.2014.10.009 https://www.sciencedirect.com/science/article/pii/S0145305X14002560 IMMUNITY Immune receptor lectins _-mannosidase-like protein M-type lectin Glyco_hydro_47 IPR001382 Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 IMMUNITY Immune receptor LRR-domain containing protein Leucine rich repeat containg protein LRR-other LRR IPR001611 IPR032675 "IPR007110,IPR007111,IPR000157" Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ IMMUNITY Immune receptor LRR-domain containing protein Leucine rich repeate and immunoglobin domain containing protein LRR-IG "LRR, Ig" "IPR001611,IPR007110" Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ IMMUNITY Immune receptor PRRs 2'-5'-oligoadenylate synthetase OAS " 2-5-oligoAdlate_synth_1_dom2/C, NT_2-5OAS_ClassI-CCAase, Polymerase_NTP_transf_dom" "IPR018952,IPR006116,IPR002934" "P00973,P29728,Q9Y6K5" Lamers et al. 2019 10.3389/fimmu.2019.01763 https://www.frontiersin.org/articles/10.3389/fimmu.2019.01763/full IMMUNITY Immune receptor PRRs ATP-binding cassette sub-family F member-like ABCF1 "AAA+_ATPase,ABC_transporter-like_ATP-bd" "IPR003593,IPR003439" Q8NE71 Goubau et al. 2013 10.1016/j.immuni.2013.05.007 https://www.sciencedirect.com/science/article/pii/S1074761313002045 IMMUNITY Immune receptor PRRs ATP-dependent DNA helicase II/X-ray repair cross-complementing protein 5/6 Ku70/80 "Ku70/Ku80_beta-barrel_dom,Ku_C,Ku_N" "IPR006164,IPR005160,IPR005161" "P12956,P13010" Q9I7M8 "Goubau et al. 2013,Paludan and Bowie 2013" "10.1016/j.immuni.2013.05.007,10.1016/j.immuni.2013.05.004" "https://www.sciencedirect.com/science/article/pii/S1074761313002045.,https://www.sciencedirect.com/science/article/pii/S107476131300201X" IMMUNITY Immune receptor PRRs "Beta 1,3-glucan recognition proteins" GRP BGBP_N IPR031756 Q9NHB0 Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ IMMUNITY Immune receptor PRRs CD36/scavenger receptor class B member 1-like CD36-like CD36/SCARB1/SNMP1 IPR005428 IPR002159 Q8WTV0 Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ IMMUNITY Immune receptor PRRs Cyclic GMP-AMP synthase cGAS Mab-21_dom IPR024810 P78527 "Goubau et al. 2013,Paludan and Bowie 2013" "10.1016/j.immuni.2013.05.007,10.1016/j.immuni.2013.05.004" "https://www.sciencedirect.com/science/article/pii/S1074761313002045.,https://www.sciencedirect.com/science/article/pii/S107476131300201X" IMMUNITY Immune receptor PRRs DNA repair protein RAD50 RAD50 "Rad50/SbcC_AAA,ABC_Rad50,Zn_hook_RAD50" "IPR038729,IPR045171,IPR013134" "IPR027417,IPR004584" Q92878 "Goubau et al. 2013,Paludan and Bowie 2013" "10.1016/j.immuni.2013.05.007,10.1016/j.immuni.2013.05.004" "https://www.sciencedirect.com/science/article/pii/S1074761313002045.,https://www.sciencedirect.com/science/article/pii/S107476131300201X" IMMUNITY Immune receptor PRRs DNA-dependent protein kinase-like DNAPK "DNA-PK_dom, DNAPKcs_CC5,DNAPKcs_CC3" "IPR037706,IPR045581,IPR012582" IPR037706 P78527 "Goubau et al. 2013,Paludan and Bowie 2013" "10.1016/j.immuni.2013.05.007,10.1016/j.immuni.2013.05.004" "https://www.sciencedirect.com/science/article/pii/S1074761313002045.,https://www.sciencedirect.com/science/article/pii/S107476131300201X" IMMUNITY Immune receptor PRRs DNA-directed RNA polymerase III RNApol_III "RNA_pol_Rpc34,WH_DNA-bd_sf" "IPR007832,IPR036390" "IPR016049,IPR036388" Q9H1D9 "Goubau et al. 2013,Paludan and Bowie 2013" "10.1016/j.immuni.2013.05.007,10.1016/j.immuni.2013.05.004" "https://www.sciencedirect.com/science/article/pii/S1074761313002045.,https://www.sciencedirect.com/science/article/pii/S107476131300201X" IMMUNITY Immune receptor PRRs Double-strand break repair protein MRE11-like MRE11 "Mre11_N,Mre11_DNA-bd" "IPR041796,IPR007281" "IPR038487,IPR004843" P49959 "Goubau et al. 2013,Paludan and Bowie 2013" "10.1016/j.immuni.2013.05.007,10.1016/j.immuni.2013.05.004" "https://www.sciencedirect.com/science/article/pii/S1074761313002045.,https://www.sciencedirect.com/science/article/pii/S107476131300201X" IMMUNITY Immune receptor PRRs EIF2AK2/PKR-like PKR "EIF2AK2_DSRM_1,EIF2AK2_DSRM_2,Prot_kinase_dom" "IPR044452,IPR044453,IPR000719" "IPR014720,IPR000719" P19525 Lamers et al. 2019 10.3389/fimmu.2019.01763 https://www.frontiersin.org/articles/10.3389/fimmu.2019.01763/full IMMUNITY Immune receptor PRRs Gram-negative bacteria binding-protein GNBP GH16 IPR000757 Q9NHB0 Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ IMMUNITY Immune receptor PRRs High mobility group box proteins HMGBs HMG_box_dom IPR009071 IPR036910 "P09429,P26583,O15347" Goubau et al. 2013 10.1016/j.immuni.2013.05.007 https://www.sciencedirect.com/science/article/pii/S1074761313002045 IMMUNITY Immune receptor PRRs Interferon-inducible proteins AIM2-like/IFI16-like "DAPIN, HIN200/IF120x" "IPR004020,IPR004021" "IPR011029,IPR004021" "O14862,Q16666" "Goubau et al. 2013,Paludan and Bowie 2013" "10.1016/j.immuni.2013.05.007,10.1016/j.immuni.2013.05.004" "https://www.sciencedirect.com/science/article/pii/S1074761313002045.,https://www.sciencedirect.com/science/article/pii/S107476131300201X" IMMUNITY Immune receptor PRRs Leucine-rich repeat flightless-interacting protein 1-like LRRFIP1 LRRFIP1/2 IPR019139 Q32MZ4 Goubau et al. 2013 10.1016/j.immuni.2013.05.007 https://www.sciencedirect.com/science/article/pii/S1074761313002045 IMMUNITY Immune receptor PRRs Monocyte differentiation antigen CD14 CD14 Monocyte_diff_Ag_CD14 IPR016337 P08571 Manes and Nita-Lazar 2021 10.1128/mSystems.00336-21 https://journals.asm.org/doi/full/10.1128/mSystems.00336-21 IMMUNITY Immune receptor PRRs Myeloid Differentiation factor 2/Lymphocyte antigen 96 MD2 ML_dom IPR003172 IPR039217 Q9Y6Y9 Manes and Nita-Lazar 2021 10.1128/mSystems.00336-21 https://journals.asm.org/doi/full/10.1128/mSystems.00336-21 IMMUNITY Immune receptor PRRs NOD-like receptor NLR "NACHT, LRR" "IPR007111,IPR001611" "IPR007111,IPR032675" "Q9Y239,Q9HC29,Q7RTR2,Q86WI3,Q86UT6,Q7RTR0,Q86W26,Q8WX94" Wicherska-Pawowska et al. 2021 10.3390/ijms222413397 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704656/ IMMUNITY Immune receptor PRRs peptidoglycan recognition proteins PGRP PGRP_domain_met/bac IPR006619 O75594 Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ IMMUNITY Immune receptor PRRs RIG-I-like receptors RLR "RIG-I_C,RLR_CTR" "IPR011545,IPR041204,IPR021673" IPR038557 "O95786,Q9BYX4,Q96C10" Wicherska-Pawowska et al. 2021 10.3390/ijms222413397 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704656/ IMMUNITY Immune receptor PRRs scavenger receptor cysteine-rich domain containing protein SRCR SRCR IPR001190 "Q4G0T1,Q8WTU2,A1L4H1" Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ IMMUNITY Immune receptor PRRs Stimulator of interferon genes STING/MITA STING_C IPR033952 IPR038623 Q86WV6 "Goubau et al. 2013,Paludan and Bowie 2013" "10.1016/j.immuni.2013.05.007,10.1016/j.immuni.2013.05.004" "https://www.sciencedirect.com/science/article/pii/S1074761313002045.,https://www.sciencedirect.com/science/article/pii/S107476131300201X" IMMUNITY Immune receptor PRRs Toll-like receptor TLR "TIR, LRR" "IPR000157,IPR001611" "IPR000157,IPR032675" "IPR000157,IPR003591" "Q15399,O60603,O15455,O00206,O60602,Q9Y2C9,Q9NYK1,Q9NR97,Q9NR96,Q9BXR5" Wicherska-Pawowska et al. 2021 10.3390/ijms222413397 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704656/ IMMUNITY Immune receptor PRRs Z-DNA-binding proteins ZBP/DAI Z_dom IPR042371 Q9H171 Paludan and Bowie 2013 10.1016/j.immuni.2013.05.004 https://www.sciencedirect.com/science/article/pii/S107476131300201X REGULATORY PATHWAYS Intracellular signal transduction Apoptosis Apoptosis regulator Bcl2- like Bcl2-like "Bcl-2_BH1-3,Bcl2_BH4" "IPR026304,IPR003093" IPR002475 Q07817 Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 REGULATORY PATHWAYS Intracellular signal transduction Apoptosis Caspases Caspase Pept_C14A IPR015917 "P29466,P42575,P42574,P49662,P51878,P55212,P55210,Q14790,P55211,Q92851" Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 REGULATORY PATHWAYS Intracellular signal transduction Apoptosis Fas apoptotic inhibitory molecule FAIM FAIM1_dom_sf IPR038513 IPR010695 Q9NVQ4 Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 REGULATORY PATHWAYS Intracellular signal transduction Apoptosis Mitochondrial apoptosis-inducing factor AIF "AIF_C,FAD/NAD-binding_dom" "IPR029324,IPR023753" "IPR029324,IPR036188" O95831 Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 REGULATORY PATHWAYS Intracellular signal transduction Apoptosis Serine protease HTRA2 HTRA2 "PDZ,PDZ_6,Peptidase_S1C" "IPR041489,IPR001478,IPR001940" O43464 Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 REGULATORY PATHWAYS Intracellular signal transduction E3 Ubiquitin ligases Baculoviral IAP repeat-containing proteins IAPs BIR_rpt IPR001370 "Q13490,Q13489" Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 REGULATORY PATHWAYS Intracellular signal transduction E3 Ubiquitin ligases E3 ubiquitin ligase Pellino Pellino Pellino_fam IPR006800 "Q96FA3,Q9HAT8,Q8N2H9" Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ REGULATORY PATHWAYS Intracellular signal transduction E3 Ubiquitin ligases E3 ubiquitin-protein ligase RNF135/RING finger protein leading to RIG-I activation RNF134/RIPLET "RNF135_SPRY_PRY_dom,Znf_RING" "IPR042723,IPR001841" "IPR001870,IPR001841" Q8IUD6 Manes and Nita-Lazar 2021 10.1128/mSystems.00336-21 https://journals.asm.org/doi/full/10.1128/mSystems.00336-21 REGULATORY PATHWAYS Intracellular signal transduction E3 Ubiquitin ligases E3 ubiquitin-protein ligase RNF31 HOIP "IBR,BUP,RNF31-UBA,RNF31_C,TRIAD_supradom,Znf_RanBP2" "IPR002867,IPR018997,IPR032065,IPR041031,IPR044066,IPR001876" "IPR032065,IPR001841,IPR036443,IPR044066,IPR018997" Q96EP0 Manes and Nita-Lazar 2021 10.1128/mSystems.00336-21 https://journals.asm.org/doi/full/10.1128/mSystems.00336-21 REGULATORY PATHWAYS Intracellular signal transduction E3 Ubiquitin ligases E3 ubiquitin-protein ligase TRIM TRIM "Znf_B-box,Znf_RING" "IPR000315,IPR001841" Q9BZY9 Manes and Nita-Lazar 2021 10.1128/mSystems.00336-21 https://journals.asm.org/doi/full/10.1128/mSystems.00336-21 REGULATORY PATHWAYS Intracellular signal transduction E3 Ubiquitin ligases E3 ubiquitin-protein ligase TRIM23 ARD1 "Bbox_C,Small_GTP-bd_dom,Znf-RING_LisH,Znf_B-box,Znf_C2H2_type" "IPR003649,IPR005225,IPR027370,IPR000315,IPR013087" "IPR024156,IPR013083,IPR036236" P36406 Sparrer et al. 2017 10.1038/s41564-017-0017-2 https://pubmed.ncbi.nlm.nih.gov/28871090/ REGULATORY PATHWAYS Intracellular signal transduction E3 Ubiquitin ligases E3 ubiquitin-protein ligase TRIM31 TRIM4 "PRY/SPRY_TRIM4, Znf_B-box,Znf_RING" "IPR035829,IPR000315,IPR001841" "IPR001870,IPR000315,IPR001841" Q9C037 Manes and Nita-Lazar 2021 10.1128/mSystems.00336-21 https://journals.asm.org/doi/full/10.1128/mSystems.00336-21 REGULATORY PATHWAYS Intracellular signal transduction E3 Ubiquitin ligases E3 ubiquitin/ISG15 ligase TRIM25/65 TRIM25/65 "B30.2/SPRY,SPRY,Znf_RING" "IPR001870,IPR003877,IPR001841" "IPR013320,IPR043136,IPR013083" "Q14258,Q6PJ69" Manes and Nita-Lazar 2021 10.1128/mSystems.00336-21 https://journals.asm.org/doi/full/10.1128/mSystems.00336-21 REGULATORY PATHWAYS Intracellular signal transduction E3 Ubiquitin ligases RanBP-type and C3HC4-type zinc finger-containing protein 1 RBCK1 HOIL1 "TRIAD,Ubiquitin-like_dom,Znf-RING_LisH,Znf_RanBP2" "IPR044066,IPR000626,IPR027370,IPR001876" "IPR026261,IPR001841,IPR036443" Q9BYM8 Manes and Nita-Lazar 2021 10.1128/mSystems.00336-21 https://journals.asm.org/doi/full/10.1128/mSystems.00336-21 REGULATORY PATHWAYS Intracellular signal transduction E3 Ubiquitin ligases RNA-binding E3 ubiquitin-protein ligase MEX3C MEX3C "KH_dom_type_1,Znf_RING" "IPR004088,IPR001841" "IPR036612,IPR013083" Q5U5Q3 Manes and Nita-Lazar 2021 10.1128/mSystems.00336-21 https://journals.asm.org/doi/full/10.1128/mSystems.00336-21 REGULATORY PATHWAYS Intracellular signal transduction E3 Ubiquitin ligases Sharpin SHARPIN "Sharpin_PH,Znf_RanBP2,Ubiquitin-like_domsf" "IPR031912,IPR001876,IPR029071" "IPR026261,IPR000626,IPR036443" IPR044066 Q9H0F6 Manes and Nita-Lazar 2021 10.1128/mSystems.00336-21 https://journals.asm.org/doi/full/10.1128/mSystems.00336-21 REGULATORY PATHWAYS Intracellular signal transduction E3 Ubiquitin ligases Suppressor of cytokine signaling SOCS "SOCS2_SH2,SOCS_box" "IPR035862,IPR001496" "IPR036036,IPR000980" "O15524,O14508" Green and Speck 2018 10.3390/v10030133 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869526/ REGULATORY PATHWAYS Intracellular signal transduction E3 Ubiquitin ligases TNF receptor-associated factors TRAF "Znf_TRAF,MATH/TRAF_dom,Znf_RING" "IPR001293,IPR002083,IPR001841" "IPR043211,IPR001293,IPR001841" "Q13077,Q12933,Q13114,Q9BUZ4,O00463,Q9Y4K3,Q6Q0C0" Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ REGULATORY PATHWAYS Intracellular signal transduction Integrated stress response "DNA damage-inducible transcript 3 protein (CHOP, c/EBPz/GADD153)" DDIT3/CHOP "bZIP,DNA_damage_induc_transcript_3" "IPR004827,IPR016670" P35638 Park et al. 2010 10.1074/jbc.M110.136259 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975157/ REGULATORY PATHWAYS Intracellular signal transduction "Interleukins, Cytokines and Hematopoietins" Granulins Granulins Granulin IPR000118 IPR037277 P28799 Buddenbor et al. 2017 10.1371/journal.pntd.0005984 https://www.ncbi.nlm.nih.gov/pubmed/29045404 REGULATORY PATHWAYS Intracellular signal transduction "Interleukins, Cytokines and Hematopoietins" Interferon alpha/beta receptor IFNAR "FN3_dom,Interferon/interleukin_rcp_dom" "IPR003961,IPR015373" "IPR013783,IPR015374" "P17181,P48551" Paludan and Bowie 2013 10.1016/j.immuni.2013.05.004 https://www.sciencedirect.com/science/article/pii/S107476131300201X REGULATORY PATHWAYS Intracellular signal transduction "Interleukins, Cytokines and Hematopoietins" Interleukin 17 IL-17 "IL-17_fam,Cystine-knot_cytokine" "IPR010345,IPR029034" "Q16552,Q9NRM6,Q9P0M4,Q8TAD2" Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ REGULATORY PATHWAYS Intracellular signal transduction "Interleukins, Cytokines and Hematopoietins" Interleukin 17 receptor IL17R "SEFIR_dom,IL-17_rcpt-like" "IPR013568,IPR039465" IPR013568 "Q96F46,Q9NRM6,Q8NAC3,Q8NFM7" Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ REGULATORY PATHWAYS Intracellular signal transduction "Interleukins, Cytokines and Hematopoietins" Macrophage migration inhibitory factor MIF Macrophage_inhib_fac_CS IPR019829 IPR001398 P14174 Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ REGULATORY PATHWAYS Intracellular signal transduction JAK/STAT Signal transducer and activator of transcription STAT "SH2,STAT_TF_alpha,STAT_TF_DNA-bd,STAT_TF_prot_interaction" "IPR000980,IPR013800,IPR013801,IPR013799" "IPR013801,IPR001217" "P42224,P52630,P40763" Green and Speck 2018 10.3390/v10030133 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869526/ REGULATORY PATHWAYS Intracellular signal transduction JAK/STAT Tyrosine-protein kinase JAK JAK "Ser-Thr/Tyr_kinase_cat_dom,JAK1-3/TYK2_PHL_dom,FERM_F1,FERM_F2" "IPR001245,IPR041381,IPR041155,IPR041046" "IPR000719,IPR000299" "P23458,O60674,P52333" Green and Speck 2018 10.3390/v10030133 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869526/ REGULATORY PATHWAYS Intracellular signal transduction MAVS pathway Mitochondrial Antiviral-Signaling Protein MAVS "CARD_IPS1, Mt_antiviral_sig_pro_met" "IPR042144,IPR026148" "IPR031964,IPR026148" Q7Z434 Goubau et al. 2013 10.1016/j.immuni.2013.05.007 https://www.sciencedirect.com/science/article/pii/S1074761313002045 REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway Activating protein 1 family AP-1 "AP-1,bZIP" "IPR000837,IPR004827" "P05412,P01100,Q8WYK2,P15336,P18847" Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway Activating protein 1 JUN JUN "Leuzip_Jun, Bzip" "IPR002112,IPR004827" REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway Apoptosis signal-regulating kinase (MAP3Ks) ASK "MAP3K_PH, MAP3K_TRAF-bd,Prot_kinase_dom" "IPR043969,IPR025136,IPR000719" Q99683 Huang et al. 2009 0.1016/j.cyto.2009.08.002 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782697/ REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway Dual specificity mitogen-activated protein kinase kinase MAP2Ks "Prot_kinase_dom,Ser/Thr_kinase_AS" "IPR000719,IPR008271" "Q02750,P36507,P46734,P45985,Q13163,P52564,O14733" Manes and Nita-Lazar 2021 10.1128/mSystems.00336-21 https://journals.asm.org/doi/full/10.1128/mSystems.00336-21 REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway Dual specificity mitogen-activated protein kinase kinase kinase MAP3Ks "Prot_kinase_dom,Ser/Thr_kinase_AS" "IPR000719,IPR008271" "Q6ZN16,Q13233,Q9Y2U5,Q99759,Q9Y6R4,Q99683,O95382,O43318,P41279,P80192,Q02779,Q16584,Q12852,O43283,Q99558" Manes and Nita-Lazar 2021 10.1128/mSystems.00336-21 https://journals.asm.org/doi/full/10.1128/mSystems.00336-21 REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway Extracellularly Regulated Kinase 1/2 ERK1/2 "ERK1/2,Prot_kinase_dom" "IPR008349,IPR000719" "P27361,P28482" Huang et al. 2009 0.1016/j.cyto.2009.08.002 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782697/ REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway Extracellularly Regulated Kinase 3/4 ERK3/4 "ERK3/4,Prot_kinase_dom" "IPR008350,IPR000719" "Q16659,P31152" Huang et al. 2009 0.1016/j.cyto.2009.08.002 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782697/ REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway Inhibitor of NFkB IkB Ankyrin_rpt IPR002110 "IPR038753,IPR036770" "P25963,Q15653,Q8NI38" "Q03017,Q9VEZ5" Goubau et al. 2013 10.1016/j.immuni.2013.05.007 https://www.sciencedirect.com/science/article/pii/S1074761313002045 REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway Inhibitor of nuclear factor kappa-B kinase subunit alpha IKK "IKBKB_SDD,Prot_kinase_dom" "IPR041185,IPR000719" O15111 Goubau et al. 2013 10.1016/j.immuni.2013.05.007 https://www.sciencedirect.com/science/article/pii/S1074761313002045 REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway Inhibitor of nuclear factor kappa-B kinase subunit epsilon IKKe/i "Prot_kinase_dom,TBK1_CCD1,TBK1_ULD" "IPR000719,IPR041309,IPR041087" Q14164 Goubau et al. 2013 10.1016/j.immuni.2013.05.007 https://www.sciencedirect.com/science/article/pii/S1074761313002045 REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway Interferon regulatory factor IRF Interferon_reg_fact_DNA-bd_dom IPR001346 "P10914,P14316,Q14653,Q15306,Q13568,O14896,P10914,Q02556,Q00978" Goubau et al. 2013 10.1016/j.immuni.2013.05.007 https://www.sciencedirect.com/science/article/pii/S1074761313002045 REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway Interleukin-1 receptor-associated kinase 1 IRAK "Death_IRAK1,Prot_kinase_dom" "IPR035533,IPR000719" "IPR011029,IPR000719" "P51617,O43187,Q9Y616,Q9NWZ3" Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway Major Vault Protein MVP "MVP_rep_dom,MVP_shoulder" "IPR041139,IPR021870" "IPR043023,IPR036013" Q14764 Wang et al. 2020 10.1002/iub.2200 https://iubmb.onlinelibrary.wiley.com/doi/full/10.1002/iub.2200 REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway MAP kinase-activated protein kinase 2 MK2 "MAPKAPK_C,Prot_kinase_dom,Ser/Thr_kinase_AS" "IPR027442,IPR000719,IPR008271" P49137 Manes and Nita-Lazar 2021 10.1128/mSystems.00336-21 https://journals.asm.org/doi/full/10.1128/mSystems.00336-21 REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway MAP3K7/TGF-beta-activated kinase 1 TAK1 "MAPKKK7,Prot_kinase_dom,Ser-Thr/Tyr_kinase_cat_dom" "IPR017421,IPR001245,IPR000719" O43318 Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway "Mitogen activated protein kinase kinase kinase 10 (MST, MLK2)" MAP3K10 "MAP3K10,Prot_kinase_dom" "IPR015785,IPR000719" Q02779 Huang et al. 2009 0.1016/j.cyto.2009.08.002 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782697/ REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway "Mitogen activated protein kinase kinase kinase 12/13 (DLK, MEKK12/13)" MAP3K12/13 "MAP3K12/13,Prot_kinase_dom" "IPR017419,IPR000719" "Q12852,O43283" Huang et al. 2009 0.1016/j.cyto.2009.08.002 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782697/ REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway Mitogen activated protein kinase kinase kinase 2/3 MAP3K1/2 "PB1_MEKK2/3,Prot_kinase_dom" "IPR034879,IPR000719" "Q13233,Q9Y2U5" Huang et al. 2009 0.1016/j.cyto.2009.08.002 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782697/ REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway "Mitogen activated protein kinase kinase kinase 4 (MEKK4, MTK1)" MAP3K4 "MAP3K4,Prot_kinase_dom" "IPR045801,IPR000719" Q9Y6R4 Huang et al. 2009 0.1016/j.cyto.2009.08.002 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782697/ REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway Mitogen activated protein kinase phosphatase MKP MKP IPR008343 Q13115 Huang et al. 2009 0.1016/j.cyto.2009.08.002 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782697/ REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway Mitogen activated protein kinases MAPKs "MAP_kinase_CS,Prot_kinase_dom" "IPR003527,IPR000719" "P28482,P27361,Q16659,P31152,Q16539,P53778,P45983,Q15759,P45984" Xie 2013 10.1186/1750-2187-8-7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697994/ REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway Mitogen-activated protein kinase 8 JNK "MAP_kinase_CS,Prot_kinase_dom,MAPK_JNK" "IPR003527,IPR000719,IPR008351" P45983 Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway Mitogen-activated protein kinase kinase 5 (MEK5) MAP2K5 "PB1_MAP2K5,Prot_kinase_dom" "IPR034851,IPR000719" Q13163 Huang et al. 2009 0.1016/j.cyto.2009.08.002 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782697/ REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway Mitogen-activated protein kinase kinase kinase 8 TPL2/MAP3K8 "Prot_kinase_dom,Ser/Thr_kinase_AS,Kinase-like_dom_sf,MAPKKK8" "IPR000719,IPR008271,IPR017424" IPR017424 P41279 Manes and Nita-Lazar 2021 10.1128/mSystems.00336-21 https://journals.asm.org/doi/full/10.1128/mSystems.00336-21 REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway Nck-associated_protein-1 NAP1 Nck-associated_protein-1 IPR019137 Q9Y2A7 Xie 2013 10.1186/1750-2187-8-7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697994/ REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway NF-kappa-B essential modulator IKKg/NEMO "NEMO_ZF,CC2-LZ_dom" "IPR034735,IPR032419" "IPR032419,IPR034735" Q9Y6K9 Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway Nuclear factor kB NFkB "IPT_NFkappaB, RHD_DNA_bind_dom" "IPR033926,IPR011539" "IPR032397,IPR011539" "P19838,Q00653,Q04206,Q01201" "Goubau et al. 2013,Paludan and Bowie 2013" "10.1016/j.immuni.2013.05.007,10.1016/j.immuni.2013.05.004" "https://www.sciencedirect.com/science/article/pii/S1074761313002045.,https://www.sciencedirect.com/science/article/pii/S107476131300201X" REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway p38 MAPK/ MAPK14 p38 "Prot_kinase_dom,MAPK_p38-like" "IPR008352,IPR000719" Q16539 Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway Receptor-interacting serine/threonine-protein kinase RIPKs "RIP1_Death,RHIM_dom,Ser-Thr/Tyr_kinase_cat_dom" "IPR037934,IPR025735,IPR001245" "IPR011029,IPR025735,IPR000719" "Q13546,O43353,Q9Y572,P57078" Newton 2015 10.1016/j.tcb.2015.01.001 https://www.sciencedirect.com/science/article/pii/S0962892415000124 REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway RIG-I and MAVS type CARD domain containing proteins RIGI/IPS1_CARD_DC CARD_dom IPR031964 REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway RIO Kinase 3 RIOK3 RIO_kinase "IPR000687,IPR017406" O14730 Feng et al. 2014 10.1128/JVI.00643-14 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097797/ REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway TANK-binding kinase 1-binding protein 1 TBKBP1/SINTBAD "CALCOCO1/2_Zn_UBZ1,TBD" "IPR041641,IPR024581" IPR024581 A7MCY6 Xie 2013 10.1186/1750-2187-8-7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697994/ REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway TANK-binding kinase 1/ NFkB activated Kinase TBK1/NAK "TBK1_ULD, TBK1_CCD1, Prot_kinase_dom" "IPR041087,IPR041309,IPR000719" Q9UHD2 Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 TAB1 PPM-type_phosphatase_dom IPR001932 Q15750 Xie 2013 10.1186/1750-2187-8-7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697994/ REGULATORY PATHWAYS Intracellular signal transduction NFkB/IRF pathway TGF-beta-activated kinase 1 and MAP3K7-binding protein 2/3 TAB2/3 "TAB2/3_CUE,Znf_RanBP2" "IPR041911,IPR001876" "IPR003892,IPR036443" "Q9NYJ8,Q8N5C8" Xie 2013 10.1186/1750-2187-8-7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697994/ REGULATORY PATHWAYS Intracellular signal transduction Other signaling A disintegrin and metalloproteinase ADAM Peptidase_M12B IPR001590 "P78536,O14672,P78325" Buddenbor et al. 2017 10.1371/journal.pntd.0005984 https://www.ncbi.nlm.nih.gov/pubmed/29045404 REGULATORY PATHWAYS Intracellular signal transduction Other signaling Catenin beta b-Catenin Beta-catenin IPR013284 P35222 "Goubau et al. 2013,Paludan and Bowie 2013" "10.1016/j.immuni.2013.05.007,10.1016/j.immuni.2013.05.004" "https://www.sciencedirect.com/science/article/pii/S1074761313002045.,https://www.sciencedirect.com/science/article/pii/S107476131300201X" REGULATORY PATHWAYS Intracellular signal transduction Other signaling GTPase IMAP family member GIMAP G_AIG1 IPR006703 "Q8WWP7,Q9UG22,Q9NUV9,Q96F15,Q6P9H5,Q8NHV1,Q8ND71" Buddenbor et al. 2017 10.1371/journal.pntd.0005984 https://www.ncbi.nlm.nih.gov/pubmed/29045404 REGULATORY PATHWAYS Intracellular signal transduction Other signaling RanBP2 domain containing proteins RanBP2DC Znf_RanBP2 IPR001876 IPR036443 Manes and Nita-Lazar 2021 10.1128/mSystems.00336-21 https://journals.asm.org/doi/full/10.1128/mSystems.00336-21 REGULATORY PATHWAYS Intracellular signal transduction Other signaling sialate O-acetylesterase SIAE SASA IPR005181 IPR039329 Q9HAT2 Buddenbor et al. 2017 10.1371/journal.pntd.0005984 https://www.ncbi.nlm.nih.gov/pubmed/29045404 REGULATORY PATHWAYS Intracellular signal transduction Other signaling Tyrosine-protein kinase Fyn FYN "Fyn/Yrk_SH3,Ser-Thr/Tyr_kinase_cat_dom" "IPR035750,IPR001245" P06241 Huang et al. 2000 10.1073/pnas.97.20.10923 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC27125/ REGULATORY PATHWAYS Intracellular signal transduction TLR adaptor moleculues Armadillo fold and TIR domain containing proteins ARM-TIR "TIR, ARM" "IPR000157,IPR000225" "IPR035897,IPR016024" Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ REGULATORY PATHWAYS Intracellular signal transduction TLR adaptor moleculues Epidermal growth factor and TIR domain containing proteins EGF-TIR "TIR, EGF-like_dom" "IPR000157,IPR000742" Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ REGULATORY PATHWAYS Intracellular signal transduction TLR adaptor moleculues Evolutionarily conserved signaling intermediate in Toll pathway ECSIT ECIST_C IPR029342 IPR010418 Q9BQ95 Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ REGULATORY PATHWAYS Intracellular signal transduction TLR adaptor moleculues Imunoglobulin and TIR domain containing proteins IG-TIR "TIR, Ig-like_dom" "IPR000157,IPR007110" Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ REGULATORY PATHWAYS Intracellular signal transduction TLR adaptor moleculues Myeloid differentiation primary response protein MyD88 "TIR,Death_domain" "IPR000157,IPR000488" Q99836 "Goubau et al. 2013,Paludan and Bowie 2013" "10.1016/j.immuni.2013.05.007,10.1016/j.immuni.2013.05.004" "https://www.sciencedirect.com/science/article/pii/S1074761313002045.,https://www.sciencedirect.com/science/article/pii/S107476131300201X" REGULATORY PATHWAYS Intracellular signal transduction TLR adaptor moleculues NAD(+) hydrolase SARM1 SARM "TIR, SAM" "IPR000157,IPR001660" Q6SZW1 Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ REGULATORY PATHWAYS Intracellular signal transduction TLR adaptor moleculues Orphan TIR proteins OrTIR TIR IPR000157 "IPR006911,IPR001660,IPR007110,IPR001440,IPR000742,IPR000488,IPR017281,IPR032675" Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ REGULATORY PATHWAYS Intracellular signal transduction TLR adaptor moleculues TIR and tetratrico peptide repeat containing proteins TIR-TPR "TIR, TPR_1" "IPR000157,IPR001440" Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ REGULATORY PATHWAYS Intracellular signal transduction TLR adaptor moleculues TIR domain-containing adapter molecule 1 TRIF/TICAM1 "RHIM,TIR,TRIF_N" "IPR025735,IPR000157,IPR040886" IPR017278 Q8IUC6 Manes and Nita-Lazar 2021 10.1128/mSystems.00336-21 https://journals.asm.org/doi/full/10.1128/mSystems.00336-21 REGULATORY PATHWAYS Intracellular signal transduction TLR adaptor moleculues TIR domain-containing adapter molecule 2 TRAM/TICAM2 "Emp24-like,TIR" "IPR015720,IPR000157" "IPR015720,IPR035897" Q86XR7 Manes and Nita-Lazar 2021 10.1128/mSystems.00336-21 https://journals.asm.org/doi/full/10.1128/mSystems.00336-21 REGULATORY PATHWAYS Intracellular signal transduction TLR adaptor moleculues Toll-interacting protein TOLLIP "TOLIP_CUE,Tollip_C2" "IPR041799,IPR037301" "IPR003892,IPR035892" Q9H0E2 Green et al. 2015 10.1099/jgv.0.000244 https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.000244#tab2 REGULATORY PATHWAYS Intracellular signal transduction TLR adaptor moleculues Toll/interleukin-1 receptor domain-containing adapter protein TIRAP/Mal "Tol-interleuk_rcpt_adapt_Tirap,TIR" "IPR017279,IPR000157" P58753 Xie 2013 10.1186/1750-2187-8-7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697994/ REGULATORY PATHWAYS Intracellular signal transduction TLR adaptor moleculues TRAF family member-associated NF-kappa-B activator TANK "CALCOCO1/2_Zn_UBZ1,TBD,TANK" "IPR041641,IPR024581,IPR039669" Q92844 Xie 2013 10.1186/1750-2187-8-7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697994/ REGULATORY PATHWAYS Intracellular signal transduction TNF pathway Caspase and RIP adapter with death domain CRADD "CARD_RAIDD,CRADD_Death" "IPR042148,IPR037926" "IPR001315,IPR000488" P78560 Hibino et al. 2006 10.1016/j.ydbio.2006.08.065 https://www.sciencedirect.com/science/article/pii/S0012160606011572?via%3Dihub REGULATORY PATHWAYS Intracellular signal transduction TNF pathway FAS-associated death domain protein FADD "DED_dom,Death_domain" "IPR001875,IPR000488" IPR016729 Q13158 Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ REGULATORY PATHWAYS Intracellular signal transduction TNF pathway Lipopolysaccharide-induced tumor necrosis factor-alpha factor LITAF LITAF IPR006629 Q99732 Seppala et al. 2021 10.1186/s12864-021-07428-1 https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1 REGULATORY PATHWAYS Intracellular signal transduction TNF pathway Tumor necrosis factor TNF TNF_dom IPR006052 P01375 Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ REGULATORY PATHWAYS Intracellular signal transduction TNF pathway Tumor necrosis factor receptor type 1-associated DEATH domain protein TRADD "Death_domain,TRADD_N" "IPR000488,IPR009095" IPR035712 Q15628 Newton 2015 10.1016/j.tcb.2015.01.001 https://www.sciencedirect.com/science/article/pii/S0962892415000124 REGULATORY PATHWAYS Intracellular signal transduction TNF pathway Tumore necrosis factor receptor TNFR TNFR/NGFR_Cys_rich_reg IPR001368 "P19438,P20333,P36941" Zhang et al. 2015 10.1038/srep08693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/ REGULATORY PATHWAYS Intracellular signal transduction Proliferation Myc proto-oncogene protein Myc "Myc-LZ,Tscrpt_reg_Myc_N" "IPR003327,IPR012682" IPR002418 P01106 Gnanaprakasam and Wang 2017 10.3390/genes8030088 https://www.mdpi.com/2073-4425/8/3/88/htm