Compound ,SMILES,"EGFR 
LR/TM IC50 (nM)","EGFR 
LR/TM/CS IC50 (nM)","EGFR 
ex19/TM/CS IC50 (nM)",pEGFR H1975 LR/TM IC50 (nM),pEGFR A431 WT (nM) 
4,OC(CC1)CCN1C2=NC=CC(NC3=NC=C(C(NC)=O)C(NC(C)C)=C3)=N2,290,266,121,914,25000
5,O[C@@H]([C@@H](F)C1)CCN1C2=NC=CC(NC3=NC=C(C(NC)=O)C(NC(C)C)=C3)=N2,99,105,66,420,25000
6,O[C@@H]([C@@H](F)C1)CCN1C2=NC=CC(NC3=NC=C4C(C(C(C)C)=CN=C4NC)=C3)=N2,50,46,35,67,25000
7,CC(C)C1=NN=C(NC)C2=CN=C(NC3=NC(N4C[C@H](F)[C@H](O)CC4)=NC=C3)C=C12,343,298,271,1469,25000
8,CC(C)C1=CN=C(NC)C2=CN=C(NC3=NC(N4C[C@@](F)(C)[C@H](O)CC4)=NC=C3)C=C12,8.1,6.5,8.7,20,"23,605"
9,CC(C)C1=CN=C(N2CCC2)C3=CN=C(NC4=NC(N5C[C@@](F)(C)[C@H](O)CC5)=NC=C4)C=C13,2.1,12,9.1,20,"8,668"
10,CC(C)C1=CN=C(N2CCCC2)C3=CN=C(NC4=NC(N5C[C@@](F)(C)[C@H](O)CC5)=NC=C4)C=C13,ND,21.5,23,52,ND
11,CC(C)C1=CN=C(N2CC[C@H]2C)C3=CN=C(NC4=NC(N5C[C@@](F)(C)[C@H](O)CC5)=NC=C4)C=C13,0.3,0.3,0.8,7,"9,965"
12,CC(C)C1=CN=C(N2CC[C@@H]2C)C3=CN=C(NC4=NC(N5C[C@@](F)(C)[C@H](O)CC5)=NC=C4)C=C13,106,113,110,210,"25,000"
13,CC(C)C1=NN=C(N2CC[C@H]2C)C3=CN=C(NC4=NC(N5C[C@@](F)(C)[C@H](O)CC5)=NC=C4)C=C13,16,12.7,9.6,25,"25,000"
14,CC(C)C1=NC=C(N2CC[C@H]2C)C3=CN=C(NC4=NC(N5C[C@@](F)(C)[C@H](O)CC5)=NC=C4)C=C13,2.2,9,6,23,"25,000"
15,CC(C)C1=CN=C(N2CC(O)C2)C3=CN=C(NC4=NC(N5C[C@@](F)(C)[C@H](O)CC5)=NC=C4)C=C13,3.6,11,8.1,41,"25,000"
16,CC(C)C1=CN=C(N2C[C@H](O)[C@H]2C)C3=CN=C(NC4=NC(N5C[C@@](F)(C)[C@H](O)CC5)=NC=C4)C=C13,0.3,0.4,0.8,7,"5,290"
17,CC(C)C1=NC=C(N2C[C@H](O)[C@H]2C)C3=CN=C(NC4=NC(N5C[C@@](F)(C)[C@H](O)CC5)=NC=C4)C=C13,1.8,10,8.1,13,"25,000"
18,CC(C)C1=CC=C(N2C[C@H](O)[C@H]2C)C3=CN=C(NC4=NC(N5C[C@@](F)(C)[C@H](O)CC5)=NC=C4)C=C13,0.5,7.5,5.5,19,"25,000"
19,CC(C)C1=CN=C(N2CC(OC)C2)C3=CN=C(NC4=NC(N5C[C@@](F)(C)[C@H](O)CC5)=NC=C4)C=C13,3.4,7.2,6.3,24,"25,000"
20,CC(C)C1=CN=C(N2CC(COC)C2)C3=CN=C(NC4=NC(N5C[C@@](F)(C)[C@H](O)CC5)=NC=C4)C=C13,11,25,24,40,"25,000"
21,CC(C)C1=CN=C(N2CC(C#N)C2)C3=CN=C(NC4=NC(N5C[C@@](F)(C)[C@H](O)CC5)=NC=C4)C=C13,ND,5.3,4.8,17,ND
22,CC(C)C1=CN=C(N2CC(C(NC)=O)C2)C3=CN=C(NC4=NC(N5C[C@@](F)(C)[C@H](O)CC5)=NC=C4)C=C13,1,1.1,3.4,32,"25,000"
23,CC(C)C1=CN=C(N2CC(C(N(C)C)=O)C2)C3=CN=C(NC4=NC(N5C[C@@](F)(C)[C@H](O)CC5)=NC=C4)C=C13,0.9,1.2,3,10,"4,126"
24,CC(C)C1=CN=C(N2CC(CS(C)(=O)=O)C2)C3=CN=C(NC4=NC(N5C[C@@](F)(C)[C@H](O)CC5)=NC=C4)C=C13,0.1,0.1,0.2,4.8,"1,608"
25,CC(C)C1=CN=C(N2C[C@H](CS(C)(=O)=O)[C@H]2C)C3=CN=C(NC4=NC(N5C[C@@](F)(C)[C@H](O)CC5)=NC=C4)C=C13,0.2,0.2,0.2,1.7,781
26,CC(C)C1=CC=C(N2CC(CS(C)(=O)=O)C2)C3=CN=C(NC4=NC(N5C[C@@](F)(C)[C@H](O)CC5)=NC=C4)C=C13,0.2,0.2,0.1,2.7,1362
27,CC(C)C1=CC=C(N2C[C@H](CS(C)(=O)=O)[C@H]2C)C3=CN=C(NC4=NC(N5C[C@@](F)(C)[C@H](O)CC5)=NC=C4)C=C13,0.3,0.2,0.3,1,1780
28,CC(C)C1=CC=C(N2C[C@H](CS(C)(=O)=O)[C@H]2C)C3=CN=C(NC4=NC(N5C[C@@](F)(CC)[C@H](O)CC5)=NC=C4)C=C13,0.5,0.4,0.4,1.8,709
29,CC(C)C1=CC=C(N2C[C@H](CS(C)(=O)=O)[C@H]2C)C3=CN=C(NC4=NC(N5C[C@H](F)[C@@](O)(C)CC5)=NC=C4)C=C13,0.4,0.5,1,3.8,1206
30,CC(C)C1=CC=C(N2C[C@H](CS(C)(=O)=O)[C@H]2C)C3=CN=C(NC4=NC(N5C[C@H](F)[C@H](OC)CC5)=NC=C4)C=C13,0.4,0.5,0.7,1.1,544
31,CC(C)C1=CC=C(N2C[C@H](CS(C)(=O)=O)[C@H]2C)C3=CN=C(NC4=NC(N5CC(F)(F)[C@H](OC)[C@H](O)C5)=NC=C4)C=C13,0.7,0.7,1.3,2.6,191