{"text_format":"3","workbook":"xlsb","n_sheets":2,"sheets":["Supplemental Table 2","Description"],"not_rendered":{"defined_names":2},"read":"whole","date_system":"1900","formulas":"cached_only","passed_over":{"ids":[37,38,1024],"n":13899}}

{"sheet":"Supplemental Table 2","index":0,"n_rows":26,"n_cols":28,"rows_kept":26,"merged":[[0,0,0,2],[0,3,0,5],[0,6,0,9],[0,10,0,25],[0,26,0,27]],"flags":["formulas_cached_only"]}
["Acetyl(K) Site Information",null,null,"Differential Expression (DE) Testing",null,null,"ANOVA testing",{"$nulls":3},"Summed fragment ion intensities",{"$nulls":15},"Additional Information"]
["Positions.within.histone","Uniprot ID","Histone","Kac.logFC.2h MS275","Kac.logFC.6h MS275","Kac.logFC.24h MS275","Significant","pValue","adj.pValue","Significant pairs","WT.Rep1","WT.Rep2","WT.Rep3","WT.Rep4","2h MS275.Rep1","2h MS275.Rep2","2h MS275.Rep3","2h MS275.Rep4","6h MS275.Rep1","6h MS275.Rep2","6h MS275.Rep3","6h MS275.Rep4","24h MS275.Rep1","24h MS275.Rep2","24h MS275.Rep3","24h MS275.Rep4","Protein.names","Acetylated peptide sequences"]
["15;16;20","O60814","H2B1K",{"v":0.2445461288758018,"d":"0.24"},{"v":0.8062106172943997,"d":"0.81"},{"v":1.9874791352659082,"d":"1.99"},"+",0.000150959344029006,{"v":0.000214523,"d":"0.000"},"24h_WT;24h_2h;24h_6h",{"v":1.14224,"d":"1.14"},{"v":0.912375,"d":"0.91"},{"v":1.06507,"d":"1.07"},{"v":0.880314,"d":"0.88"},{"v":1.49144,"d":"1.49"},{"v":1.45112,"d":"1.45"},{"v":1.14991,"d":"1.15"},{"v":0.64641,"d":"0.65"},{"v":2.35404,"d":"2.35"},{"v":2.05997,"d":"2.06"},{"v":1.21598,"d":"1.22"},{"v":1.36446,"d":"1.36"},{"v":4.68851,"d":"4.69"},{"v":5.24135,"d":"5.24"},{"v":3.17001,"d":"3.17"},{"v":2.76187,"d":"2.76"},"Histone H2B type 1-K","GSKacKacAVTKacAQK"]
["16; 20","O60814","H2B1K",{"v":0.0918338589343919,"d":"0.09"},{"v":0.593573684531242,"d":"0.59"},{"v":2.1289441499154202,"d":"2.13"},"+",1.4334745933758139e-06,{"v":2.41896e-06,"d":"0.000"},"24h_WT;24h_2h;24h_6h",{"v":1.25971,"d":"1.26"},{"v":1.01219,"d":"1.01"},{"v":0.857765,"d":"0.86"},{"v":0.870341,"d":"0.87"},{"v":1.26995,"d":"1.27"},{"v":1.31602,"d":"1.32"},{"v":0.821507,"d":"0.82"},{"v":0.855419,"d":"0.86"},{"v":1.73147,"d":"1.73"},{"v":1.74233,"d":"1.74"},{"v":1.04884,"d":"1.05"},{"v":1.51328,"d":"1.51"},{"v":4.524,"d":"4.52"},{"v":5.30489,"d":"5.30"},{"v":3.42525,"d":"3.43"},{"v":4.24175,"d":"4.24"},"Histone H2B type 1-K","KacAVTKacAQK"]
["12;15;16;20","O60814","H2B1K",{"v":-0.0980321900355532,"d":"-0.10"},{"v":1.178454119985566,"d":"1.18"},{"v":3.070270386522371,"d":"3.07"},"+",0.000759276572646525,{"v":0.00102502,"d":"0.001"},"24h_2h;24h_WT;24h_6h",{"v":1.02249,"d":"1.02"},{"v":0.91968,"d":"0.92"},{"v":1.21997,"d":"1.22"},{"v":0.837865,"d":"0.84"},{"v":1.11769,"d":"1.12"},{"v":0.872408,"d":"0.87"},{"v":1.42472,"d":"1.42"},{"v":0.322408,"d":"0.32"},{"v":3.62822,"d":"3.63"},{"v":2.95733,"d":"2.96"},{"v":1.65629,"d":"1.66"},{"v":0.811525,"d":"0.81"},{"v":9.17223,"d":"9.17"},{"v":15.1575,"d":"15.16"},{"v":6.12146,"d":"6.12"},{"v":3.14604,"d":"3.15"},"Histone H2B type 1-K","KacGSKacKacAVTKacAQK"]
[5,"O60814","H2B1K",{"v":0.4980057162153978,"d":"0.50"},{"v":1.8809156720996003,"d":"1.88"},{"v":3.369362832025277,"d":"3.37"},"+",8.187475246818958e-08,{"v":2.76327e-07,"d":"0.000"},"6h_WT;24h_WT;6h_2h;24h_2h;24h_6h",{"v":1.17074,"d":"1.17"},{"v":0.907846,"d":"0.91"},{"v":0.985759,"d":"0.99"},{"v":0.935656,"d":"0.94"},{"v":1.74098,"d":"1.74"},{"v":1.80189,"d":"1.80"},{"v":1.17212,"d":"1.17"},{"v":0.93405,"d":"0.93"},{"v":4.74901,"d":"4.75"},{"v":4.33196,"d":"4.33"},{"v":2.28743,"d":"2.29"},{"v":3.36395,"d":"3.36"},{"v":11.3693,"d":"11.37"},{"v":12.5512,"d":"12.55"},{"v":8.26287,"d":"8.26"},{"v":9.15366,"d":"9.15"},"Histone H2B type 1-K","M*PEPAKacSAPAPK"]
[20,"Q5QNW6","H2B2F",{"v":0.3778544924924393,"d":"0.38"},{"v":0.2564002109805218,"d":"0.26"},{"v":1.4077103211468642,"d":"1.41"},"",0.08243089210431226,{"v":0.0967672,"d":"0.097"},"",{"v":1.24858,"d":"1.25"},{"v":1.27076,"d":"1.27"},{"v":0.586397,"d":"0.59"},{"v":0.894263,"d":"0.89"},{"v":1.75139,"d":"1.75"},{"v":2.31465,"d":"2.31"},{"v":0.64449,"d":"0.64"},{"v":0.487102,"d":"0.49"},{"v":0.994531,"d":"0.99"},{"v":1.6149,"d":"1.61"},{"v":0.950227,"d":"0.95"},{"v":1.21832,"d":"1.22"},{"v":2.85611,"d":"2.86"},{"v":4.47537,"d":"4.48"},{"v":1.73635,"d":"1.74"},{"v":1.5448,"d":"1.54"},"Histone H2B type 2-F","AVTKacVQK"]
["15;16","Q5QNW6","H2B2F",{"v":0.4612322893861459,"d":"0.46"},{"v":1.4416547761694116,"d":"1.44"},{"v":2.556094607587947,"d":"2.56"},"+",3.8927812521005666e-05,{"v":5.83918e-05,"d":"0.000"},"6h_WT;24h_WT;6h_2h;24h_2h;24h_6h",{"v":1.31304,"d":"1.31"},{"v":1.10525,"d":"1.11"},{"v":0.748574,"d":"0.75"},{"v":0.833137,"d":"0.83"},{"v":1.77857,"d":"1.78"},{"v":2.0905,"d":"2.09"},{"v":0.850839,"d":"0.85"},{"v":0.78696,"d":"0.79"},{"v":2.65492,"d":"2.65"},{"v":3.65566,"d":"3.66"},{"v":1.70589,"d":"1.71"},{"v":2.84882,"d":"2.85"},{"v":6.2094,"d":"6.21"},{"v":7.7271,"d":"7.73"},{"v":4.59082,"d":"4.59"},{"v":4.99722,"d":"5.00"},"Histone H2B type 2-F","GSKacKacAVTK"]
["16;20","Q5QNW6","H2B2F",{"v":0.1406710221378054,"d":"0.14"},{"v":0.6061863580465354,"d":"0.61"},{"v":1.9585513234833656,"d":"1.96"},"+",3.157839115862372e-07,{"v":7.10507e-07,"d":"0.000"},"6h_WT;24h_WT;24h_2h;24h_6h",{"v":1.15752,"d":"1.16"},{"v":0.986135,"d":"0.99"},{"v":0.950806,"d":"0.95"},{"v":0.905539,"d":"0.91"},{"v":1.21154,"d":"1.21"},{"v":1.3096,"d":"1.31"},{"v":1.04599,"d":"1.05"},{"v":0.842541,"d":"0.84"},{"v":1.82963,"d":"1.83"},{"v":1.62757,"d":"1.63"},{"v":1.07916,"d":"1.08"},{"v":1.55256,"d":"1.55"},{"v":3.88638,"d":"3.89"},{"v":4.42344,"d":"4.42"},{"v":3.31281,"d":"3.31"},{"v":3.92423,"d":"3.92"},"Histone H2B type 2-F","KacAVTKacVQK"]
["12;15;16","Q5QNW6","H2B2F",{"v":0.4658227450662365,"d":"0.47"},{"v":2.0785936111168795,"d":"2.08"},{"v":4.073773113622404,"d":"4.07"},"+",1.930323065022639e-08,{"v":8.68639e-08,"d":"0.000"},"6h_WT;24h_WT;6h_2h;24h_2h;24h_6h",{"v":1.11463,"d":"1.11"},{"v":0.949675,"d":"0.95"},{"v":0.998938,"d":"1.00"},{"v":0.936761,"d":"0.94"},{"v":1.68408,"d":"1.68"},{"v":1.61615,"d":"1.62"},{"v":1.27041,"d":"1.27"},{"v":0.953779,"d":"0.95"},{"v":5.57439,"d":"5.57"},{"v":5.39375,"d":"5.39"},{"v":2.38861,"d":"2.39"},{"v":3.53906,"d":"3.54"},{"v":17.9323,"d":"17.93"},{"v":22.2565,"d":"22.26"},{"v":13.3231,"d":"13.32"},{"v":13.8459,"d":"13.85"},"Histone H2B type 2-F","KacGSKacKacAVTK"]
["12;15;16;20","Q5QNW6","H2B2F",{"v":-0.5696488838160214,"d":"-0.57"},{"v":1.5825587727932002,"d":"1.58"},{"v":4.63268612931346,"d":"4.63"},"+",1.6195337393832433e-05,{"v":2.5722e-05,"d":"0.000"},"6h_2h;24h_2h;24h_WT;24h_6h",{"v":0.967335,"d":"0.97"},{"v":1.04609,"d":"1.05"},{"v":1.29707,"d":"1.30"},{"v":0.689502,"d":"0.69"},{"v":0.630816,"d":"0.63"},{"v":0.55786,"d":"0.56"},{"v":1.02684,"d":"1.03"},{"v":0.479607,"d":"0.48"},{"v":3.53651,"d":"3.54"},{"v":5.19847,"d":"5.20"},{"v":2.49573,"d":"2.50"},{"v":0.749313,"d":"0.75"},{"v":25.9174,"d":"25.92"},{"v":40.6746,"d":"40.67"},{"v":25.9072,"d":"25.91"},{"v":6.72954,"d":"6.73"},"Histone H2B type 2-F","KacGSKacKacAVTKacVQK"]
["11;12","Q5QNW6","H2B2F",{"v":0.4958491441962297,"d":"0.50"},{"v":1.9692656321045234,"d":"1.97"},{"v":4.39088775955001,"d":"4.39"},"+",2.4020940086369064e-07,{"v":5.89601e-07,"d":"0.000"},"6h_WT;24h_WT;6h_2h;24h_2h;24h_6h",{"v":1.22051,"d":"1.22"},{"v":0.990442,"d":"0.99"},{"v":0.795024,"d":"0.80"},{"v":0.994025,"d":"0.99"},{"v":1.86392,"d":"1.86"},{"v":1.95434,"d":"1.95"},{"v":0.938572,"d":"0.94"},{"v":0.88377,"d":"0.88"},{"v":4.81508,"d":"4.82"},{"v":5.45548,"d":"5.46"},{"v":2.05299,"d":"2.05"},{"v":3.3392,"d":"3.34"},{"v":20.8454,"d":"20.85"},{"v":32.0125,"d":"32.01"},{"v":15.0436,"d":"15.04"},{"v":16.0153,"d":"16.02"},"Histone H2B type 2-F","SAPAPKacKacGSK"]
["11;12;15","Q5QNW6","H2B2F",{"v":0.6083811007883795,"d":"0.61"},{"v":2.360755450935209,"d":"2.36"},{"v":4.736207078220398,"d":"4.74"},"+",3.659906579458331e-07,{"v":7.52983e-07,"d":"0.000"},"6h_WT;24h_WT;6h_2h;24h_2h;24h_6h",{"v":1.08378,"d":"1.08"},{"v":0.998805,"d":"1.00"},{"v":0.867131,"d":"0.87"},{"v":1.05028,"d":"1.05"},{"v":1.83412,"d":"1.83"},{"v":2.08588,"d":"2.09"},{"v":1.33503,"d":"1.34"},{"v":0.84316,"d":"0.84"},{"v":7.46895,"d":"7.47"},{"v":7.08489,"d":"7.08"},{"v":2.45043,"d":"2.45"},{"v":3.5413,"d":"3.54"},{"v":27.263,"d":"27.26"},{"v":43.1986,"d":"43.20"},{"v":18.8214,"d":"18.82"},{"v":17.3276,"d":"17.33"},"Histone H2B type 2-F","SAPAPKacKacGSKacK"]
["4;7;11","Q71UI9-2","H2AV-2",{"v":1.16420058724477,"d":"1.16"},{"v":3.2825495227592345,"d":"3.28"},{"v":4.832926713834955,"d":"4.83"},"+",4.84585037135522e-07,{"v":8.72249e-07,"d":"0.000"},"6h_WT;24h_WT;6h_2h;24h_2h;24h_6h",{"v":1.15739,"d":"1.16"},{"v":1.18637,"d":"1.19"},{"v":0.843057,"d":"0.84"},{"v":0.813185,"d":"0.81"},{"v":2.7214,"d":"2.72"},{"v":3.98118,"d":"3.98"},{"v":1.21794,"d":"1.22"},{"v":1.04384,"d":"1.04"},{"v":11.2517,"d":"11.25"},{"v":14.8625,"d":"14.86"},{"v":4.77811,"d":"4.78"},{"v":8.03065,"d":"8.03"},{"v":29.7886,"d":"29.79"},{"v":36.7454,"d":"36.75"},{"v":24.1312,"d":"24.13"},{"v":23.3377,"d":"23.34"},"Histone H2A.v2","M*AGGKacAGKacDSGKacAK"]
[]
["18;23","P84243","H33",{"v":0.4846357042666396,"d":"0.48"},{"v":1.7189862477292368,"d":"1.72"},{"v":3.659139651221271,"d":"3.66"},"+",5.643519110199515e-10,{"v":1.52374e-08,"d":"0.000"},"6h_WT;24h_WT;6h_2h;24h_2h;24h_6h",{"v":0.899399,"d":"0.90"},{"v":1.08476,"d":"1.08"},{"v":1.0664,"d":"1.07"},{"v":0.949441,"d":"0.95"},{"v":1.42565,"d":"1.43"},{"v":1.26946,"d":"1.27"},{"v":1.15093,"d":"1.15"},{"v":1.75089,"d":"1.75"},{"v":2.86818,"d":"2.87"},{"v":4.69545,"d":"4.70"},{"v":2.94738,"d":"2.95"},{"v":2.65719,"d":"2.66"},{"v":12.3948,"d":"12.39"},{"v":14.405,"d":"14.41"},{"v":13.2682,"d":"13.27"},{"v":10.4645,"d":"10.46"},"Histone H3.3","KacQLATKacAAR"]
["9;14","P84243","H33",{"v":0.9389914387755425,"d":"0.94"},{"v":2.083066963447767,"d":"2.08"},{"v":3.757476685147781,"d":"3.76"},"+",8.588355242938097e-09,{"v":5.7971e-08,"d":"0.000"},"2h_WT;6h_WT;24h_WT;6h_2h;24h_2h;24h_6h",{"v":1.08886,"d":"1.09"},{"v":0.943956,"d":"0.94"},{"v":0.902428,"d":"0.90"},{"v":1.06476,"d":"1.06"},{"v":2.1175,"d":"2.12"},{"v":2.2822,"d":"2.28"},{"v":1.24459,"d":"1.24"},{"v":2.02446,"d":"2.02"},{"v":3.46728,"d":"3.47"},{"v":6.15508,"d":"6.16"},{"v":3.80855,"d":"3.81"},{"v":3.51737,"d":"3.52"},{"v":13.1504,"d":"13.15"},{"v":17.5662,"d":"17.57"},{"v":12.2804,"d":"12.28"},{"v":11.1,"d":"11.10"},"Histone H3.3","Kn_acSTGGKacAPR"]
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[]
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["8;12;16","P62805","H4",{"v":1.435171179218621,"d":"1.44"},{"v":2.77256768736794,"d":"2.77"},{"v":3.8671749360751955,"d":"3.87"},"+",1.527214363646531e-09,{"v":1.53649e-08,"d":"0.000"},"2h_WT;6h_WT;24h_WT;6h_2h;24h_2h;24h_6h",{"v":0.961036,"d":"0.96"},{"v":0.977986,"d":"0.98"},{"v":0.98521,"d":"0.99"},{"v":1.07577,"d":"1.08"},{"v":2.60096,"d":"2.60"},{"v":2.44143,"d":"2.44"},{"v":2.28069,"d":"2.28"},{"v":3.49349,"d":"3.49"},{"v":5.89416,"d":"5.89"},{"v":10.4173,"d":"10.42"},{"v":6.34695,"d":"6.35"},{"v":4.67451,"d":"4.67"},{"v":13.4336,"d":"13.43"},{"v":15.5447,"d":"15.54"},{"v":15.2214,"d":"15.22"},{"v":14.1711,"d":"14.17"},"Histone H4","GGKacGLGKacGGAKacR"]
["5;8","P62805","H4",{"v":0.8222365904551115,"d":"0.82"},{"v":1.805733039808522,"d":"1.81"},{"v":3.2836017962423973,"d":"3.28"},"+",1.7072220054141604e-09,{"v":1.53649e-08,"d":"0.000"},"2h_WT;6h_WT;24h_WT;6h_2h;24h_2h;24h_6h",{"v":1.06544,"d":"1.07"},{"v":0.962901,"d":"0.96"},{"v":0.994111,"d":"0.99"},{"v":0.977544,"d":"0.98"},{"v":1.78744,"d":"1.79"},{"v":1.66082,"d":"1.66"},{"v":1.22947,"d":"1.23"},{"v":2.39485,"d":"2.39"},{"v":2.97859,"d":"2.98"},{"v":4.26839,"d":"4.27"},{"v":3.25913,"d":"3.26"},{"v":3.47816,"d":"3.48"},{"v":9.20887,"d":"9.21"},{"v":8.37759,"d":"8.38"},{"v":10.5941,"d":"10.59"},{"v":10.7708,"d":"10.77"},"Histone H4","GKacGGKacGLGK"]
["5;8;12","P62805","H4",{"v":0.44820585918965944,"d":"0.45"},{"v":1.1313178422777943,"d":"1.13"},{"v":2.709404237970126,"d":"2.71"},"+",2.7254611765405193e-08,{"v":1.05125e-07,"d":"0.000"},"6h_WT;24h_WT;6h_2h;24h_2h;24h_6h",{"v":0.991066,"d":"0.99"},{"v":0.93999,"d":"0.94"},{"v":1.02769,"d":"1.03"},{"v":1.04125,"d":"1.04"},{"v":1.54977,"d":"1.55"},{"v":1.21582,"d":"1.22"},{"v":1.61361,"d":"1.61"},{"v":1.07817,"d":"1.08"},{"v":2.34851,"d":"2.35"},{"v":2.35325,"d":"2.35"},{"v":2.47441,"d":"2.47"},{"v":1.58618,"d":"1.59"},{"v":7.3159,"d":"7.32"},{"v":7.465,"d":"7.47"},{"v":6.68907,"d":"6.69"},{"v":4.69209,"d":"4.69"},"Histone H4","GKacGGKacGLGKacGGAK"]
["5;8;12;16","P62805","H4",{"v":1.122505416128297,"d":"1.12"},{"v":3.5920192287640607,"d":"3.59"},{"v":6.496486717065841,"d":"6.50"},"+",1.689468115646632e-07,{"v":4.56152e-07,"d":"0.000"},"6h_WT;24h_WT;6h_2h;24h_2h;24h_6h",{"v":0.689226,"d":"0.69"},{"v":1.00893,"d":"1.01"},{"v":1.19099,"d":"1.19"},{"v":1.11086,"d":"1.11"},{"v":2.02977,"d":"2.03"},{"v":1.97964,"d":"1.98"},{"v":2.2851,"d":"2.29"},{"v":2.41448,"d":"2.41"},{"v":10.2866,"d":"10.29"},{"v":21.9834,"d":"21.98"},{"v":12.1806,"d":"12.18"},{"v":3.78476,"d":"3.78"},{"v":98.916,"d":"98.92"},{"v":115.779,"d":"115.78"},{"v":115.207,"d":"115.21"},{"v":31.2561,"d":"31.26"},"Histone H4","GKacGGKacGLGKacGGAKacR"]
["12;16","P62805","H4",{"v":1.0373312611076804,"d":"1.04"},{"v":1.7442396880102513,"d":"1.74"},{"v":2.4036297142872542,"d":"2.40"},"+",1.6808153283328438e-08,{"v":8.68639e-08,"d":"0.000"},"2h_WT;6h_WT;24h_WT;6h_2h;24h_2h;24h_6h",{"v":1.02983,"d":"1.03"},{"v":0.989436,"d":"0.99"},{"v":0.996303,"d":"1.00"},{"v":0.984434,"d":"0.98"},{"v":2.10725,"d":"2.11"},{"v":1.81322,"d":"1.81"},{"v":1.56154,"d":"1.56"},{"v":2.7277,"d":"2.73"},{"v":2.74263,"d":"2.74"},{"v":4.07106,"d":"4.07"},{"v":3.27825,"d":"3.28"},{"v":3.30879,"d":"3.31"},{"v":4.99534,"d":"5.00"},{"v":4.84669,"d":"4.85"},{"v":5.76165,"d":"5.76"},{"v":5.56163,"d":"5.56"},"Histone H4","GLGKacGGAKacR"]
[{"$nulls":27},"*[Met-loss (Protein N-term M)]"]

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["Supplemental Table 2 - Supplement to Figure S3: Targeted proteomics approach"]
[]
[null,"Summary of quantified acetyl(K) sites identified by our targeted proteomics approach (4 experimental conditions, four replicates). This table includes Differential Expression (DE) Testing analysis of acetylated peptides of histones (normalized to unmodified peptides) (colums D-F), correponding statistical analysis (G-J), summed fragment ion intensities (K-Z) and additional information (AA-AB). The table covers information on MS-275 treated wildtype cells (2, 6 or 24 hour time points)."]
{"$rows_empty":8}
[null,"Column Name","Description"]
[null,"Positions.within.histone","Indicates position of acetyl-lysine in the histone protein. N-terminal methionines are not considered, to fit the commonly used histone site code."]
[null,"WT","Wildtype (HAP1 cells)."]
[null,"2h, 6h, 24h MS-275","WT cells treated for 2, 6, or 24 hours with MS-275, respectively."]
[null,"LogFC","Fold change [log2] over untreated WT. "]
[null,"Significant pairs","Indicates pairs with significant differences based on one-way ANOVA testing (padj-value ≤ 0.05), separated by semicolon."]
[null,"pVal","P-value, column is hidden."]
[null,"adjpV","Adjusted p-value."]
[null,"Summed fragment ion intensities","Summed fragment ion intensities for each peptide variant."]
[null,"Rep1, 2, 3","Replicate 1, 2, or 3."]
[null,"Protein.names*","Names of proteins this peptide is associated with. "]
[null,"Ac","Lysine acetylation."]
[null,"nAc","N-term lysine acetylation."]