Id,Structure,T. b. brucei 20S proteasome IC50 (nM),human 20S proteasome IC50 (nM),T.b. brucei EC50 (nM),HTS Sol Qualifier,HTS Sol,MLM Qualifier,MLM,RLM Qualifier,RLM,HLM Qualifier,HLM,MDR1 AtoB Qualifier,MDR1 AtoB,MDR1 ER Qualifier,MDR1 ER,MW
Compound 1,Cc3ccc2nc(cc(Nc1ccccc1)c2c3)C(=O)N4CCCC4,764, >10000,360,,0.017000001,,,,330,,76.099999,,18.43,,0.63999999,331.4
Compound 2,Cc3ccc2nc(cc(Nc1ccccc1)c2c3)C(=O)NC4CCCC4,12, >10000,55,<,0.004,,576,,122,,220,,,,,345.4
Compound 3,Cc3ccc2nc(cc(Nc1ccccc1F)c2c3)C(=O)NC[C@@H](O)CO,18, >10000,6.8,,0.128,,78.83,,40.6,<,25,,14.18,,0.91000003,369.4
Compound 4,Cc3ccc2nc(cc(Nc1ccccc1F)c2c3)C(=O)NC[C@@H](F)CO,7.7, >10000,3.5,,0.099,,145,,36.9,<,25,,8.8599997,,0.92000002,371.4
Compound 5,OC[C@H](F)CNC(=O)c3cc(Nc1ccccc1F)c2cc(Br)ccc2n3,5.4, >10000,5.3,,0.022,,65,<,25,<,25,,6.27,,0.66000003,436.3
Compound 6,OC[C@H](F)CNC(=O)c3cc(Nc1ccccc1F)c2cc(Cl)ccc2n3,4.7, >10000,5.4,,0.007,,55.300001,<,25,<,25,,8.0200005,,0.69,391.8
Compound 7,CO[C@@H](CO)CNC(=O)c3cc(Nc1cccc(F)c1F)c2cc(Cl)ccc2n3,6.3, -  ,<2.5,,0.012,,78.910001,,65.666667,,33.7,,8.1800003,,0.81999999,421.8
Compound 8,Cc2cc1c(cc(nc1cn2)C(=O)NC3CC3)Nc4ccccc4F,13,>10000,29,,0.087,,177,,33,,25.299999,,21.16,,0.62000001,336.4
Compound 9,Cc2cc1c(cc(nc1cn2)C(=O)NC3CC3)Nc4c(F)cccc4F,22, >10000,51,,0.146,,84.2,,27.5,<,25,,16.450001,,0.67000002,354.4
Compound 10,Cc2cc1c(cc(nc1cn2)C(=O)N[C@H]3CCN(C)C[C@H]3F)Nc4ccccc4F,12, >10000,7.9,,0.229,,44,,83.599999,<,25,,7.52,,1.83,411.5
Compound 11,Cc2cc1c(cc(nc1cn2)C(=O)NC[C@@H](O)CO)Nc3ccccc3F,210, -,130,,0.006,<,25,<,25,<,25,,2.1860001,,9.0790005,370.4
Compound 12,Cc2cc1c(cc(nc1cn2)C(=O)NCC(C)(C)C#N)Nc3ccccc3F,10.4, -,35,,0.086,,131,,69.626667,,33.900002,,12.82,,0.97000003,377.4
Compound 13,C/C=C/c1cnc(cc1Nc2ccccc2F)C(=O)NCCOC,17, >10000,46,,0.18,,394,,114,,62.200001,,13.51,,0.62000001,329.4
Compound 14,C/C=C/c1cnc(cc1Nc2ccccc2F)C(=O)NC[C@@H](F)CO,19, >10000,13,,0.37000001,,90.699997,,47.700001,<,25,,12.8,,0.63,347.4
Compound 15,CCOc1cnc(cc1Nc2cccc(F)c2F)C(=O)NC[C@@H](F)CO, -, -,60,,0.35,,95.25,,42.550001,<,25,,13.75,,0.68000001,369.3
Compound 16,CO[C@@H](CO)CNC(=O)c3cc(Nc1ccccc1F)c2cc(F)ccc2n3, -, -,37,,0.091,,43.4,,43.1,<,25,,7.54,,1,387.4
Compound 17,Cc2cc1c(cc(nc1cn2)C(=O)NCCC#N)Nc3ccccc3F, -, -,94,,0.01,,86.469997,<,25,<,25,,13.15,,0.80000001,349.4
Compound 18,COCCNC(=O)c3cc(Nc1ccccc1F)c2cc(C)ncc2n3, -, -,40,,0.107,,151,,51.599999,<,25,,19.98,,0.58999997,354.4
Compound 19,Cc2cc1c(cc(nc1cn2)C(=O)NC3CCOCC3)Nc4ccccc4F, -, -,95,<,0.004,,50.799999,,46.050001,<,25,,18.219999,,0.70999998,380.4
Compound 20,Cc3ccc2nc(cc(Nc1ccccc1F)c2c3)C(=O)NCCC#N, -, -,14,<,0.004,,588,,59,,40.4,,9.21,,0.52999997,348.4
Compound 21,Cc2cc1c(cc(nc1cn2)C(=O)NC3CC3)Nc4ccccc4, -, -,53,,0.011,,414,,62.200001,,54.599999,,12.38,,0.61000001,318.4