Supplementary Table S3. Performance of three strategies,,,,,,,,,,,,,,,,,,,,,,,, Time point,Clonal mutations only,,,,,,,,Clonal and subclonal mutations,,,,,,,,Clonal and filtered subclonal mutations,,,,,,, ,tp,fp,tn,fn,sensitivity,specificity,ppv,npv,tp,fp,tn,fn,sensitivity,specificity,ppv,npv,tp,fp,tn,fn,sensitivity,specificity,ppv,npv Presurgical,17,23,59,16,0.5152,0.7195,0.425,0.7867,20,28,54,13,0.6061,0.6585,0.4167,0.806,17,25,57,16,0.5152,0.6951,0.4048,0.7808 P1 (7 days),9,5,78,24,0.2727,0.9398,0.6429,0.7647,14,11,72,19,0.4242,0.8675,0.56,0.7912,10,5,78,23,0.303,0.9398,0.6667,0.7723 P2 (3 months),8,3,77,26,0.2353,0.9625,0.7273,0.7476,10,11,69,24,0.2941,0.8625,0.4762,0.7419,10,5,75,24,0.2941,0.9375,0.6667,0.7576 P3 (6 months),7,3,65,14,0.3333,0.9559,0.7,0.8228,7,7,61,14,0.3333,0.8971,0.5,0.8133,7,3,65,14,0.3333,0.9559,0.7,0.8228 Postsurgical,24,12,71,10,0.7059,0.8554,0.6667,0.8765,27,29,54,7,0.7941,0.6506,0.4821,0.8852,25,14,69,9,0.7353,0.8313,0.641,0.8846