Table 1S. Detailed clinical information for the 42 CN-AML samples from TCGA database Bcr_patient_barcode Birth_days_to Gender Race History_other_malignancy History_hematologic_disorder History_neoadjuvant_treatment History_neoadjuvant_hydroxyurea_tx Hydroxyurea_tx_days Total_dose History_exposure_leukemogenic_agents History_chemical_exposure_other Vital_status Death_days_to Cells_used_for_analysis_source Initial_pathologic_dx_year Age_at_diagnosis Percent_blasts_peripheral_blood Fab_category Cyto_and_immuno_test_performed Percent_cellularity WBC_24hr_of_banking Hemoglobin_24hr_of_banking Platelet_count_preresection Blast_count Promyelocytes_count Myelocytes_24hr_of_banking Metamyelocytes_24hr_of_banking Bands_24hr_of_banking Segs_24hr_of_banking Basophils_count Basophils_count Lymphocytes_count Monocytes_count Prolymphocytes_24hr_of_banking Promonocytes_24hr_of_banking Abnormal_lymphocyte_percent Cytogenetics_testing_performed Metaphases_count Cyto_risk_group Cytogenetic_abnormality_type Cyto_abnormality_type_other Fish_performed_indicator Fish_abnormality_detected Test_performed_indicator Fish_performed_outcome Molecular_abnormality_detected Molecular_abnormality_results Informed_consent_verified Initial_pathologic_dx_days_to Tissue_source_site TCGA_AB_2805 -28124 MALE WHITE Yes NO No NO 0 0 Radiation [Not Available] Dead 577 Bone marrow aspirate 2002 77 67 M0 Undifferentiated MPX Negative|NSE Negative|TDT Not Tested|CD3 Not Tested|CD5 Not Tested|CD7 Not Tested|CD10 Not Tested|CD14 Positive|CD15 Not Tested|CD19 Negative|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Not Tested|CD45 Not Tested|CD56 Not Tested|CD56 Negative|HLA-DR Positive|Other CD Not Tested 90 92 9 105 56 0 0 0 0 1 0 0 9 34 0 0 0 YES 20 Intermediate/Normal Normal No NO [Not Available] [Not Available] [Not Available] [Not Available] FLT3 Mutation Negative|IDH1 R132 Negative|IDH1 R140 Positive|IDH1 R172 Negative|Activating RAS Negative|NPMc Negative YES 0 AB TCGA_AB_2811 -29766 MALE WHITE No NO No NO 0 0 [Not Available] [Not Available] Dead 243 Bone marrow aspirate 2002 81 98 M4 MPX Positive|NSE Positive|TDT Not Tested|CD3 Not Tested|CD5 Not Tested|CD7 Negative|CD10 Not Tested|CD14 Negative|CD15 Negative|CD19 Negative|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Negative|CD45 Not Tested|CD56 Not Tested|CD117 Positive|HLA-DR Positive|Other CD Positive 95 91 11 32 37 0 2 0 1 2 0 0 14 20 0 0 0 YES 25 Intermediate/Normal Normal [Not Available] YES NO PML-RAR 4 [Not Available] FLT3 Mutation Positive|IDH1 R132 Negative|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Negative|NPMc Positive YES 0 AB TCGA_AB_2812 -9253 FEMALE BLACK OR AFRICAN AMERICAN No NO Yes YES 3 4000 None [Not Available] Dead 366 Bone marrow aspirate 2004 25 53 M2 MPX Positive|NSE Negative|TDT Not Tested|CD3 Not Tested|CD5 Not Tested|CD7 Positive|CD10 Not Tested|CD14 Negative|CD15 Not Tested|CD19 Negative|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Negative|CD45 Not Tested|CD56 Negative|CD117 Positive|HLA-DR Positive|Other CD Negative 100 34 11 23 87 0 0 0 0 1 0 0 10 0 0 2 0 YES 20 Intermediate/Normal Normal [Not Available] YES NO PML-RAR 0 [Not Available] FLT3 Mutation Positive|IDH1 R132 Negative|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Negative|NPMc Negative YES 0 AB TCGA_AB_2818 -22707 FEMALE ASIAN No NO No NO [Not Available] [Not Available] None [Not Available] Dead 303 Bone marrow aspirate 2002 62 46 M2 MPX Positive|NSE Negative|TDT Not Tested|CD3 Not Tested|CD5 Not Tested|CD7 Not Tested|CD10 Not Tested|CD14 Not Tested|CD15 Not Tested|CD19 Not Tested|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Negative|CD45 Positive|CD56 Not Tested|CD117 Positive|HLA-DR Positive|Other CD Not Tested [Not Available] 75 11 110 53 4 0 0 2 21 0 0 12 7 1 0 0 YES 20 Intermediate/Normal Normal [Not Available] NO [Not Available] [Not Available] [Not Available] [Not Available] FLT3 Mutation Positive|IDH1 R132 Negative|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Negative|NPMc Positive YES 0 AB TCGA_AB_2825 -11384 FEMALE WHITE No NO Yes YES 1 2000 None [Not Available] Dead 212 Bone marrow aspirate 2006 31 83 M5 MPX Positive|NSE Positive|TDT Not Tested|CD3 Not Tested|CD5 Not Tested|CD7 Not Tested|CD10 Not Tested|CD14 Not Tested|CD15 Not Tested|CD19 Positive|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Not Tested|CD45 Not Tested|CD56 Not Tested|CD 117 Not Tested|HLA-DR Not Tested|Other CD Positive 90 137 6 42 6 0 0 0 0 0 0 0 4 76 0 14 0 YES 20 Intermediate/Normal Normal [Not Available] YES NO PML-RAR|MLL 1|1 [Not Available] FLT3 Mutation Positive|IDH1 R132 Negative|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Negative|NPMc Positive YES 0 AB TCGA_AB_2826 -23468 FEMALE WHITE No NO Yes YES 2 2000 None [Not Available] Dead 731 Bone marrow aspirate 2002 64 72 M4 NA Not Tested|MPX Positive|NSE Positive|TDT Not Tested|CD3 Not Tested|CD5 Not Tested|CD7 Negative|CD10 Not Tested|CD14 Not Tested|CD15 Not Tested|CD19 Negative|CD20 Negative|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Negative|CD45 Not Tested|CD56 Negative|CD117 Positive|HLA-DR Positive|Other CD Not Tested 90 132 10 15 90 0 0 0 0 2 0 0 8 0 0 0 0 YES 20 Intermediate/Normal Normal [Not Available] [Not Available] [Not Available] [Not Available] [Not Available] [Not Available] FLT3 Mutation Negative|IDH1 R132 Negative|IDH1 R140 Positive|IDH1 R172 Negative|Activating RAS Negative|NPMc Positive YES 0 AB TCGA_AB_2830 -23404 FEMALE WHITE No NO No NO [Not Available] [Not Available] [Not Available] [Not Available] Dead 275 Bone marrow aspirate 2005 64 85 M4 MPX Positive|NSE Positive|TDT Not Tested|CD3 Not Tested|CD5 Not Tested|CD7 Not Tested|CD10 Not Tested|CD14 Not Tested|CD15 Not Tested|CD19 Positive|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Positive|CD45 Not Tested|CD56 Not Tested|CD117 Positive|HLA-DR Not Tested|Other CD Not Tested 90 3 11 134 22 0 1 0 0 9 0 0 65 3 0 0 0 YES 20 Intermediate/Normal Normal [Not Available] YES NO PML-RAR|CBF-Beta|AML1-ETO 0|0|0 [Not Available] FLT3 Mutation Negative|IDH1 R132 Negative|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Negative|NPMc Negative YES 0 AB TCGA_AB_2836 -12904 MALE WHITE No NO No NO [Not Available] [Not Available] [Not Available] [Not Available] Dead 518 Bone marrow aspirate 2005 35 90 M4 MPX Not Tested|NSE Positive|TDT Not Tested|CD3 Not Tested|CD5 Not Tested|CD7 Not Tested|CD10 Not Tested|CD14 Not Tested|CD15 Not Tested|CD19 Not Tested|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Not Tested|CD45 Not Tested|CD56 Not Tested|CD117 Positive|HLA-DR Positive|Other CD Not Tested 100 53 8 44 18 6 3 0 3 15 1 0 3 33 0 0 7 YES 20 Intermediate/Normal Normal [Not Available] YES NO MLL 0 [Not Available] FLT3 Mutation Negative|IDH1 R132 Negative|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Negative|NPMc Positive YES 0 AB TCGA_AB_2839 -18963 FEMALE WHITE No NO Yes YES 2 2000 None [Not Available] Dead 486 Bone marrow aspirate 2003 51 64 M2 MPX Positive|NSE Negative|TDT Not Tested|CD3 Not Tested|CD5 Not Tested|CD7 Positive|CD10 Not Tested|CD14 Not Tested|CD15 Not Tested|CD19 Negative|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Positive|CD45 Not Tested|CD56 Not Tested|CD117 Positive|HLA-DR Positive|Other CD Not Tested 90 42 13 232 79 0 0 1 0 0 0 0 0 0 0 0 0 YES 20 Intermediate/Normal Normal [Not Available] YES NO PML-RAR 3 [Not Available] FLT3 Mutation Positive|IDH1 R132 Negative|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Positive|NPMc Positive YES 0 AB TCGA_AB_2845 -13728 FEMALE WHITE No NO No NO [Not Available] [Not Available] None [Not Available] Dead 304 Bone marrow aspirate 2002 37 52 M2 MPX Positive|NSE Negative|TDT Not Tested|CD3 Not Tested|CD5 Not Tested|CD7 Positive|CD10 Not Tested|CD14 Not Tested|CD15 Not Tested|CD19 Not Tested|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Positive|CD45 Positive|CD56 Not Tested|CD117 Positive|HLA-DR Positive|Other CD Not Tested 90 19 9 38 33 0 1 0 0 33 10 0 14 9 0 0 0 YES 20 Intermediate/Normal Normal [Not Available] NO [Not Available] [Not Available] [Not Available] [Not Available] FLT3 Mutation Negative|IDH1 R132 Negative|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Negative|NPMc Negative YES 0 AB TCGA_AB_2851 -24319 FEMALE WHITE No NO No NO [Not Available] [Not Available] None [Not Available] Dead 242 Bone marrow aspirate 2005 66 32 M5 MPX Positive|NSE Positive|TDT Not Tested|CD3 Not Tested|CD5 Not Tested|CD7 Not Tested|CD10 Not Tested|CD14 Positive|CD15 Not Tested|CD19 Not Tested|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Not Tested|CD45 Not Tested|CD56 Not Tested|CD 117 Not Tested|HLA-DR Not Tested|Other CD Positive 70 79 12 132 11 0 0 1 3 10 0 1 16 46 0 0 12 YES 20 Intermediate/Normal Normal [Not Available] YES NO MLL 2.5 [Not Available] FLT3 Mutation Positive|IDH1 R132 Negative|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Negative|NPMc Negative YES 0 AB TCGA_AB_2853 -18720 MALE WHITE No NO No NO [Not Available] [Not Available] None [Not Available] Dead 89 Bone marrow aspirate 2003 51 85 M1 MPX Positive|NSE Negative|TDT Not Tested|CD3 Not Tested|CD5 Not Tested|CD7 Negative|CD10 Not Tested|CD14 Not Tested|CD15 Not Tested|CD19 Negative|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Negative|CD45 Not Tested|CD56 Negative|CD117 Positive|HLA-DR Positive|Other CD Not Tested 100 104 12 23 85 1 0 2 0 1 0 0 9 2 0 0 0 YES 20 Intermediate/Normal Normal [Not Available] NO [Not Available] [Not Available] [Not Available] [Not Available] FLT3 Mutation Positive|IDH1 R132 Negative|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Negative|NPMc Negative YES 0 AB TCGA_AB_2856 -23317 MALE WHITE No NO No NO [Not Available] [Not Available] [Not Available] [Not Available] Dead 150 Bone marrow aspirate 2006 63 82 M4 NA Not Tested|MPX Not Tested|NSE Not Tested|TDT Not Tested|CD3 Not Tested|CD5 Not Tested|CD7 Not Tested|CD10 Not Tested|CD14 Not Tested|CD15 Not Tested|CD19 Not Tested|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Positive|CD45 Not Tested|CD56 Not Tested|CD117 Positive|HLA-DR Not Tested|Other CD Not Tested 90 77 10 41 39 6 7 2 7 16 3 0 11 9 0 0 0 YES 20 Intermediate/Normal Normal [Not Available] YES NO PML-RAR|MLL|CBF-Beta 0|0|0 [Not Available] FLT3 Mutation Positive|IDH1 R132 Negative|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Negative|NPMc Negative YES 0 AB TCGA_AB_2859 -14671 MALE BLACK OR AFRICAN AMERICAN No NO No NO [Not Available] [Not Available] None [Not Available] Dead 304 Bone marrow aspirate 2005 40 47 M2 MPX Positive|NSE Negative|TDT Not Tested|CD3 Not Tested|CD5 Not Tested|CD7 Not Tested|CD10 Not Tested|CD14 Not Tested|CD15 Not Tested|CD19 Not Tested|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Negative|CD45 Not Tested|CD56 Not Tested|CD117 Positive|HLA-DR Not Tested|Other CD Not Tested 90 8 10 95 23 0 0 0 0 33 1 1 38 2 0 0 2 YES 13 Intermediate/Normal Normal [Not Available] NO [Not Available] [Not Available] [Not Available] [Not Available] FLT3 Mutation Negative|IDH1 R132 Negative|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Negative|NPMc Positive YES 0 AB TCGA_AB_2866 -24684 MALE WHITE No NO No NO [Not Available] [Not Available] [Not Available] [Not Available] Dead 153 Bone marrow aspirate 2005 67 89 M1 MPX Positive|NSE Negative|TDT Not Tested|CD3 Not Tested|CD5 Not Tested|CD7 Not Tested|CD10 Not Tested|CD14 Not Tested|CD15 Not Tested|CD19 Positive|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Negative|CD45 Not Tested|CD56 Positive|CD56 Negative|HLA-DR Positive|Other CD Positive 90 31 10 141 61 0 0 0 1 16 0 0 16 6 0 0 0 YES 20 Intermediate/Normal Normal [Not Available] YES NO PML-RAR 1 [Not Available] FLT3 Mutation Negative|IDH1 R132 Negative|IDH1 R140 Positive|IDH1 R172 Negative|Activating RAS Negative|NPMc Negative YES 0 AB TCGA_AB_2867 -24257 FEMALE WHITE No NO No NO [Not Available] [Not Available] None [Not Available] Dead 184 Bone marrow aspirate 2002 66 70 M2 MPX Positive|NSE Negative|TDT Not Tested|CD3 Not Tested|CD5 Not Tested|CD7 Not Tested|CD10 Not Tested|CD14 Negative|CD15 Negative|CD19 Negative|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Positive|CD45 Not Tested|CD56 Negative|CD117 Positive|HLA-DR Positive|Other CD Positive 50 3 12 168 6 0 0 0 0 4 0 0 68 5 0 0 17 YES 20 Intermediate/Normal Normal [Not Available] NO [Not Available] [Not Available] [Not Available] NO BCR-ABL Negative|[Not Evaluated]|FLT3 Mutation Negative|IDH1 R132 Positive|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Negative|NPMc Negative YES 0 AB TCGA_AB_2884 -16285 FEMALE WHITE No NO Yes YES 3 10000 None [Not Available] Dead 731 Bone marrow aspirate 2008 44 86 M1 MPX Positive|NSE Negative|TDT Not Tested|CD3 Not Tested|CD5 Not Tested|CD7 Not Tested|CD10 Not Tested|CD14 Not Tested|CD15 Not Tested|CD19 Not Tested|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Not Tested|CD45 Not Tested|CD56 Not Tested|CD117 Positive|HLA-DR Positive|Other CD Not Tested 85 14 9 145 17 0 1 0 0 10 0 0 27 38 0 5 2 YES 20 Intermediate/Normal Normal [Not Available] YES NO PML-RAR|CBF-Beta|AML1-ETO 0|0|0 NO FLT3 Mutation Negative|IDH1 R132 Negative|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Negative|NPMc Positive YES 0 AB TCGA_AB_2896 -7882 FEMALE WHITE No NO Yes YES 2 3000 None [Not Available] Dead 214 Bone marrow aspirate 2007 21 90 M5 MPX Positive|NSE Positive|TDT Not Tested|CD3 Not Tested|CD5 Not Tested|CD7 Not Tested|CD10 Not Tested|CD14 Not Tested|CD15 Not Tested|CD19 Not Tested|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Positive|CD45 Not Tested|CD56 Not Tested|CD117 Positive|HLA-DR Positive|Other CD Not Tested 90 93 [Not Available] 73 72 2 1 0 0 1 1 10 6 4 0 3 0 YES 20 Intermediate/Normal Normal [Not Available] YES NO BCR-ABL|PML-RAR|CBF-Beta|AML1-ETO|+8|-7 or del(7q) 0|0|0|0|0|0 YES FLT3 Mutation Positive|IDH1 R132 Negative|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Negative|NPMc Positive YES 0 AB TCGA_AB_2899 -27787 FEMALE WHITE No NO No NO [Not Available] [Not Available] None [Not Available] Dead 671 Bone marrow aspirate 2006 76 37 M4 MPX Negative|NSE Negative|TDT Positive|CD3 Not Tested|CD5 Not Tested|CD7 Not Tested|CD10 Not Tested|CD14 Not Tested|CD15 Not Tested|CD19 Not Tested|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Not Tested|CD34 Positive|CD45 Not Tested|CD56 Not Tested|CD117 Positive|HLA-DR Not Tested|Other CD Not Tested 30 3 11 166 0 0 0 0 0 12 0 2 61 22 0 0 3 YES 20 Intermediate/Normal Normal [Not Available] YES YES PML-RAR|CBF-Beta|AML1-ETO|Other 0|0|0|55 [Not Available] FLT3 Mutation Negative|IDH1 R132 Negative|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Negative|NPMc Negative YES 0 AB TCGA_AB_2900 -25627 MALE BLACK OR AFRICAN AMERICAN No NO Yes YES 4 7000 None [Not Available] Dead 184 Bone marrow aspirate 2009 70 84 M1 MPX Not Tested|NSE Not Tested|TDT Not Tested|CD3 Not Tested|CD5 Not Tested|CD7 Not Tested|CD10 Not Tested|CD14 Not Tested|CD15 Not Tested|CD19 Not Tested|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Negative|CD45 Not Tested|CD56 Not Tested|CD 117 Not Tested|HLA-DR Not Tested|Other CD Not Tested 90 48 10 30 49 7 0 0 3 3 8 0 5 11 0 14 0 YES 20 Intermediate/Normal Normal [Not Available] YES NO PML-RAR|MLL|CBF-Beta|AML1-ETO|+8|-7 or del(7q)|-5 or del(5q) 0|0|0|0|0|0|0 [Not Available] FLT3 Mutation Positive|IDH1 R132 Negative|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Negative|NPMc Positive YES 0 AB TCGA_AB_2925 -20850 MALE WHITE No NO No NO [Not Available] [Not Available] None [Not Available] Dead 243 Bone marrow aspirate 2007 57 52 M5 MPX Positive|NSE Positive|TDT Not Tested|CD3 Not Tested|CD5 Not Tested|CD7 Not Tested|CD10 Not Tested|CD14 Not Tested|CD15 Not Tested|CD19 Not Tested|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Positive|CD45 Not Tested|CD56 Not Tested|CD 117 Not Tested|HLA-DR Not Tested|Other CD Not Tested 90 99 10 80 4 0 3 6 8 69 1 0 5 4 0 0 0 YES 20 Intermediate/Normal Normal [Not Available] YES NO BCR-ABL 0 YES BCR-ABL Negative|FLT3 Mutation Positive|IDH1 R132 Negative|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Negative|NPMc Positive YES 0 AB TCGA_AB_2927 -32326 FEMALE WHITE No NO No NO [Not Available] [Not Available] None [Not Available] Dead 90 Bone marrow aspirate 2009 88 33 M1 MPX Negative|NSE Negative|TDT Not Tested|CD3 Not Tested|CD5 Negative|CD7 Not Tested|CD10 Not Tested|CD14 Negative|CD15 Not Tested|CD19 Negative|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Negative|CD34 Positive|CD45 Not Tested|CD56 Negative|CD117 Positive|HLA-DR Positive|Other CD Negative 10 3 10 156 0 0 0 0 0 6 2 1 72 20 0 0 0 YES 20 Intermediate/Normal Normal [Not Available] NO [Not Available] [Not Available] [Not Available] [Not Available] FLT3 Mutation Negative|IDH1 R132 Negative|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Negative|NPMc Negative YES 0 AB TCGA_AB_2933 -21396 MALE WHITE No NO No NO [Not Available] [Not Available] None [Not Available] Dead 122 Bone marrow aspirate 2007 58 79 M4 MPX Positive|NSE Positive|TDT Not Tested|CD3 Not Tested|CD5 Negative|CD7 Not Tested|CD10 Not Tested|CD14 Negative|CD15 Not Tested|CD19 Negative|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Positive|CD45 Not Tested|CD56 Negative|CD117 Positive|HLA-DR Positive|Other CD Negative 100 101 9 57 64 4 6 3 2 2 1 0 11 7 0 0 0 YES 20 Intermediate/Normal Normal [Not Available] YES YES BCR-ABL|PML-RAR|MLL|CBF-Beta|AML1-ETO|TEL-AML 1|+8|-7 or del(7q)|Other 0|0|0|0|0|0|0|0|63 NO BCR-ABL Negative|PML-RAR Negative|FLT3 Mutation Negative|IDH1 R132 Negative|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Negative|NPMc Negative YES 0 AB TCGA_AB_2938 -27881 MALE WHITE No NO No NO [Not Available] [Not Available] [Not Available] [Not Available] Dead 304 Bone marrow aspirate 2005 76 33 M7 MPX Negative|NSE Negative|TDT Not Tested|CD3 Not Tested|CD5 Not Tested|CD7 Not Tested|CD10 Not Tested|CD14 Negative|CD15 Not Tested|CD19 Not Tested|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Positive|CD45 Positive|CD56 Not Tested|CD117 Positive|HLA-DR Not Tested|Other CD Negative 90 4 8 21 6 0 0 0 2 50 1 0 28 13 0 0 0 YES 20 Intermediate/Normal Normal [Not Available] YES NO BCR-ABL|PML-RAR|CBF-Beta|AML1-ETO 1|0|1|0 [Not Available] FLT3 Mutation Negative|IDH1 R132 Negative|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Negative|NPMc Negative YES 0 AB TCGA_AB_2948 -24714 MALE WHITE No NO Yes YES 3 2000 None [Not Available] Dead 580 Bone marrow aspirate 2007 67 30 M4 MPX Positive|NSE Positive|TDT Not Tested|CD3 Not Tested|CD5 Not Tested|CD7 Not Tested|CD10 Not Tested|CD14 Not Tested|CD15 Not Tested|CD19 Not Tested|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Positive|CD45 Not Tested|CD56 Not Tested|CD117 Positive|HLA-DR Positive|Other CD Not Tested 90 26 9 64 6 0 5 4 4 39 0 0 16 25 0 0 1 YES 20 Intermediate/Normal Normal [Not Available] YES NO BCR-ABL|PML-RAR|CBF-Beta|AML1-ETO|+8|-7 or del(7q)|-5 or del(5q) 1|1|1|2|0|0|0 NO FLT3 Mutation Negative|IDH1 R132 Negative|IDH1 R140 Positive|IDH1 R172 Negative|Activating RAS Negative|NPMc Negative YES 0 AB TCGA_AB_2955 -20484 FEMALE WHITE No NO No NO [Not Available] [Not Available] None [Not Available] Dead 489 Bone marrow aspirate 2007 56 60 M2 MPX Positive|NSE Positive|TDT Not Tested|CD3 Not Tested|CD5 Not Tested|CD7 Not Tested|CD10 Not Tested|CD14 Not Tested|CD15 Not Tested|CD19 Not Tested|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Positive|CD45 Not Tested|CD56 Not Tested|CD117 Positive|HLA-DR Positive|Other CD Not Tested 80 203 10 45 96 0 0 0 0 0 0 0 4 0 0 0 0 YES 20 Intermediate/Normal Normal [Not Available] YES NO BCR-ABL|PML-RAR|MLL|CBF-Beta|AML1-ETO|+8|-7 or del(7q)|Other 0|0|0|0|0|0|0|4 [Not Available] FLT3 Mutation Negative|IDH1 R132 Negative|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Negative|NPMc Negative YES 0 AB TCGA_AB_2959 -26114 MALE WHITE No NO No NO [Not Available] [Not Available] None [Not Available] Dead 489 Bone marrow aspirate 2007 71 90 M0 Undifferentiated MPX Positive|NSE Negative|TDT Positive|CD3 Not Tested|CD5 Not Tested|CD7 Not Tested|CD10 Not Tested|CD14 Not Tested|CD15 Not Tested|CD19 Not Tested|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Not Tested|CD34 Positive|CD45 Not Tested|CD56 Not Tested|CD117 Positive|HLA-DR Positive|Other CD Not Tested 30 1 11 86 13 0 0 0 0 8 1 0 75 2 0 0 1 YES 20 Intermediate/Normal Normal [Not Available] YES NO PML-RAR|MLL|CBF-Beta|AML1-ETO|+8|-7 or del(7q)|-5 or del(5q) 2|2|2|2|2|1.5|1 NO FLT3 Mutation Negative|IDH1 R132 Negative|IDH1 R140 Positive|IDH1 R172 Negative|Activating RAS Negative|NPMc Negative YES 0 AB TCGA_AB_2963 -20485 MALE WHITE No NO No NO 0 0 None [Not Available] Dead 1642 Bone marrow aspirate 2002 56 90 M1 MPX Positive|NSE Negative|TDT Not Tested|CD3 Not Tested|CD5 Not Tested|CD7 Not Tested|CD10 Not Tested|CD14 Not Tested|CD15 Not Tested|CD19 Not Tested|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Not Tested|CD45 Not Tested|CD56 Not Tested|CD117 Positive|HLA-DR Not Tested|Other CD Positive 90 31 10 88 45 8 2 0 2 8 0 0 5 24 0 0 6 YES 20 Intermediate/Normal Normal [Not Available] NO [Not Available] [Not Available] [Not Available] [Not Available] FLT3 Mutation Positive|IDH1 R132 Negative|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Negative|NPMc Positive YES 0 AB TCGA_AB_2965 -22006 MALE WHITE No NO Yes YES 1 1000 None [Not Available] Dead 335 Bone marrow aspirate 2006 60 89 M4 MPX Positive|NSE Positive|TDT Not Tested|CD3 Not Tested|CD5 Not Tested|CD7 Not Tested|CD10 Not Tested|CD14 Not Tested|CD15 Not Tested|CD19 Not Tested|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Not Tested|CD45 Not Tested|CD56 Not Tested|CD117 Positive|HLA-DR Not Tested|Other CD Positive 90 68 8 174 56 0 2 1 0 2 0 8 16 2 0 13 0 YES 20 Intermediate/Normal Normal [Not Available] NO [Not Available] [Not Available] [Not Available] [Not Available] FLT3 Mutation Positive|IDH1 R132 Negative|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Negative|NPMc Positive YES 0 AB TCGA_AB_2966 -20880 FEMALE WHITE No NO Yes YES 1 500 None [Not Available] Dead 854 Bone marrow aspirate 2007 57 43 M2 MPX Positive|NSE Negative|TDT Not Tested|CD3 Not Tested|CD5 Not Tested|CD7 Not Tested|CD10 Not Tested|CD14 Not Tested|CD15 Not Tested|CD19 Not Tested|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Positive|CD45 Not Tested|CD56 Positive|CD117 Positive|HLA-DR Positive|Other CD Not Tested 80 3 9 28 35 0 0 0 0 0 0 0 64 0 0 0 1 YES 20 Intermediate/Normal Normal [Not Available] YES NO PML-RAR|MLL|CBF-Beta|AML1-ETO|-7 or del(7q) 1|0|0|0|0 NO FLT3 Mutation Negative|IDH1 R132 Negative|IDH1 R140 Positive|IDH1 R172 Negative|Activating RAS Negative|NPMc Negative YES 0 AB TCGA_AB_2970 -12569 FEMALE WHITE Yes NO No NO [Not Available] [Not Available] None [Not Available] Dead 305 Bone marrow aspirate 2007 34 71 M4 MPX Positive|NSE Positive|TDT Not Tested|CD3 Not Tested|CD5 Negative|CD7 Not Tested|CD10 Not Tested|CD14 Negative|CD15 Not Tested|CD19 Negative|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Positive|CD45 Not Tested|CD56 Negative|CD117 Positive|HLA-DR Positive|Other CD Negative 90 20 11 152 58 0 0 0 1 3 0 0 11 20 0 6 1 YES 20 Intermediate/Normal Normal [Not Available] YES NO PML-RAR|CBF-Beta 0|0 YES PML-RAR Negative|FLT3 Mutation Positive|IDH1 R132 Negative|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Negative|NPMc Negative YES 0 AB TCGA_AB_2971 -27790 FEMALE WHITE No NO No NO [Not Available] [Not Available] None [Not Available] Dead 792 Bone marrow aspirate 2007 76 91 M4 MPX Positive|NSE Positive|TDT Not Tested|CD3 Not Tested|CD5 Not Tested|CD7 Not Tested|CD10 Not Tested|CD14 Positive|CD15 Not Tested|CD19 Not Tested|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Not Tested|CD45 Not Tested|CD56 Positive|CD117 Positive|HLA-DR Positive|Other CD Not Tested 90 5 10 52 16 0 0 0 0 4 0 0 32 27 0 17 3 YES 20 Intermediate/Normal Normal [Not Available] YES NO BCR-ABL|PML-RAR|MLL|CBF-Beta 0|0|0|0 NO FLT3 Mutation Negative|IDH1 R132 Negative|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Negative|NPMc Positive YES 0 AB TCGA_AB_2973 -24837 FEMALE WHITE No NO No NO [Not Available] [Not Available] None [Not Available] Dead 609 Bone marrow aspirate 2007 68 75 M4 MPX Positive|NSE Positive|TDT Not Tested|CD3 Not Tested|CD5 Not Tested|CD7 Not Tested|CD10 Not Tested|CD14 Not Tested|CD15 Not Tested|CD19 Not Tested|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Not Tested|CD45 Not Tested|CD56 Not Tested|CD117 Positive|HLA-DR Not Tested|Other CD Positive 90 15 8 79 10 0 1 0 1 16 0 0 29 30 0 10 3 YES 20 Intermediate/Normal Normal [Not Available] YES NO BCR-ABL|PML-RAR|CBF-Beta 0|0|0 NO FLT3 Mutation Negative|IDH1 R132 Negative|IDH1 R140 Positive|IDH1 R172 Negative|Activating RAS Negative|NPMc Positive YES 0 AB TCGA_AB_2976 -19570 MALE WHITE No NO Yes YES 1 1000 None [Not Available] Dead 915 Bone marrow aspirate 2007 53 86 M1 MPX Positive|NSE Negative|TDT Not Tested|CD3 Not Tested|CD5 Not Tested|CD7 Not Tested|CD10 Not Tested|CD14 Not Tested|CD15 Not Tested|CD19 Not Tested|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Negative|CD45 Not Tested|CD56 Not Tested|CD117 Positive|HLA-DR Not Tested|Other CD Not Tested 90 88 9 30 52 0 1 0 4 35 0 0 6 1 0 1 0 YES 20 Intermediate/Normal Normal [Not Available] YES NO BCR-ABL|PML-RAR 0|0 YES FLT3 Mutation Positive|IDH1 R132 Negative|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Negative|NPMc Positive YES 0 AB TCGA_AB_2977 -26053 FEMALE WHITE No NO No NO [Not Available] [Not Available] None [Not Available] Dead 31 Bone marrow aspirate 2008 71 70 M2 MPX Positive|NSE Negative|TDT Not Tested|CD3 Not Tested|CD5 Negative|CD7 Not Tested|CD10 Not Tested|CD14 Negative|CD15 Not Tested|CD19 Negative|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Negative|CD45 Not Tested|CD56 Negative|CD117 Positive|HLA-DR Negative|Other CD Negative 90 36 8 44 67 0 0 0 1 2 1 0 14 8 0 7 0 YES 20 Intermediate/Normal Normal [Not Available] YES NO PML-RAR|CBF-Beta|AML1-ETO|-5 or del(5q) 1|0|0|0 NO FLT3 Mutation Negative|IDH1 R132 Positive|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Negative|NPMc Negative YES 0 AB TCGA_AB_2983 -16589 MALE WHITE No [Not Available] No NO 0 0 None [Not Available] Dead 335 Bone marrow aspirate 2006 45 0 M0 Undifferentiated MPX Negative|NSE Negative|TDT Not Tested|CD3 Not Tested|CD5 Not Tested|CD7 Not Tested|CD10 Not Tested|CD14 Not Tested|CD15 Not Tested|CD19 Not Tested|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Positive|CD45 Not Tested|CD56 Not Tested|CD117 Positive|HLA-DR Not Tested|Other CD Not Tested 30 2 12 156 0 0 0 0 0 29 5 0 53 13 0 0 0 YES 20 Intermediate/Normal Normal [Not Available] [Not Available] [Not Available] [Not Available] [Not Available] [Not Available] FLT3 Mutation Negative|IDH1 R132 Negative|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Negative|NPMc Negative YES 0 AB TCGA_AB_2986 -11596 FEMALE WHITE No NO No NO [Not Available] [Not Available] None [Not Available] Dead 212 Bone marrow aspirate 2008 31 63 M2 MPX Positive|NSE Negative|TDT Not Tested|CD3 Not Tested|CD5 Negative|CD7 Not Tested|CD10 Not Tested|CD14 Not Tested|CD15 Not Tested|CD19 Negative|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Positive|CD45 Positive|CD56 Not Tested|CD117 Positive|HLA-DR Positive|Other CD Not Tested 95 13 11 36 45 0 0 0 0 20 1 0 33 1 0 0 0 YES 20 Intermediate/Normal Normal [Not Available] YES NO PML-RAR|CBF-Beta|AML1-ETO 0|0|0 YES FLT3 Mutation Positive|IDH1 R132 Negative|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Negative|NPMc Positive YES 0 AB TCGA_AB_2988 -24717 FEMALE WHITE No NO No NO [Not Available] [Not Available] None [Not Available] Dead 30 Bone marrow aspirate 2008 67 76 M1 MPX Positive|NSE Negative|TDT Not Tested|CD3 Not Tested|CD5 Negative|CD7 Not Tested|CD10 Not Tested|CD14 Negative|CD15 Not Tested|CD19 Negative|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Positive|CD45 Not Tested|CD56 Negative|CD117 Positive|HLA-DR Positive|Other CD Negative 15 46 13 71 49 0 2 1 3 13 1 0 20 10 0 1 0 YES 20 Intermediate/Normal Normal [Not Available] YES NO -5 or del(5q) 0 YES FLT3 Mutation Positive|IDH1 R132 Negative|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Negative|NPMc Positive YES 0 AB TCGA_AB_2992 -11839 FEMALE WHITE No NO No NO [Not Available] [Not Available] None [Not Available] Dead 1706 Bone marrow aspirate 2003 32 94 M1 MPX Positive|NSE Negative|TDT Not Tested|CD3 Not Tested|CD5 Not Tested|CD7 Not Tested|CD10 Not Tested|CD14 Not Tested|CD15 Not Tested|CD19 Not Tested|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Negative|CD45 Not Tested|CD56 Not Tested|CD117 Positive|HLA-DR Negative|Other CD Not Tested 95 5 9 39 70 0 0 0 0 0 0 0 30 0 0 0 0 YES 20 Intermediate/Normal Normal [Not Available] YES NO BCR-ABL 0 [Not Available] FLT3 Mutation Negative|IDH1 R132 Positive|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Negative|NPMc Positive YES 0 AB TCGA_AB_3002 -25171 MALE WHITE No [Not Available] No NO 0 0 [Not Available] [Not Available] Dead 1431 Bone marrow aspirate 2005 68 48 M2 MPX Positive|NSE Negative|TDT Not Tested|CD3 Not Tested|CD5 Not Tested|CD7 Not Tested|CD10 Not Tested|CD14 Not Tested|CD15 Not Tested|CD19 Not Tested|CD20 Not Tested|CD23 Not Tested|CD25 Negative|CD33 Not Tested|CD34 Positive|CD45 Not Tested|CD56 Not Tested|CD117 Positive|HLA-DR Not Tested|Other CD Not Tested 50 6 7 96 48 0 1 4 3 6 0 0 29 7 0 0 2 YES 20 Intermediate/Normal Normal [Not Available] YES NO BCR-ABL 0 [Not Available] IDH1 R132 Negative|IDH1 R140 Positive|IDH1 R172 Negative|Activating RAS Negative|NPMc Negative YES 0 AB TCGA_AB_3008 -8159 MALE WHITE No NO Yes YES 3 8000 None [Not Available] Dead 822 Bone marrow aspirate 2005 22 71 M1 MPX Positive|NSE Negative|TDT Not Tested|CD3 Not Tested|CD5 Not Tested|CD7 Not Tested|CD10 Not Tested|CD14 Not Tested|CD15 Not Tested|CD19 Not Tested|CD20 Not Tested|CD23 Not Tested|CD25 Not Tested|CD33 Positive|CD34 Positive|CD45 Not Tested|CD56 Not Tested|CD117 Positive|HLA-DR Not Tested|Other CD Not Tested 90 115 8 32 90 0 0 0 0 0 0 0 9 0 0 1 0 YES 30 Intermediate/Normal Normal [Not Available] YES NO PML-RAR|MLL|CBF-Beta 3|0|1 [Not Available] FLT3 Mutation Negative|IDH1 R132 Negative|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Negative|NPMc Negative YES 0 AB TCGA_AB_3009 -8676 MALE [Not Available] No NO No NO [Not Available] [Not Available] None [Not Available] Dead 577 Bone marrow aspirate 2005 23 51 M4 MPX Positive|NSE Positive|CD33 Positive|CD34 Positive|CD56 Positive|CD117 Positive [Not Available] 27 12 23 63 18 0 0 0 0 0 0 18 0 0 1 0 YES 20 Intermediate/Normal Normal [Not Available] NO [Not Available] [Not Available] [Not Available] [Not Available] FLT3 Mutation Negative|IDH1 R132 Negative|IDH1 R140 Negative|IDH1 R172 Negative|Activating RAS Negative|NPMc Negative YES 0 AB