Compound Number,Compound Name,Smiles,IC50 (biochemical),"EC50
(Calu 3/SARS2)",EC50 (VeroE6+CP/SARS2),"EC50 
(Huh7/SARS2)","EC50 
(A549-ACE2-TMPRSS2)"
1,(R)-3-Cyclopropyl-2-hydroxypropanoic acid ,O[C@H](CC1CC1)C(O)=O,,,,,
2,Methyl (R)-3-cyclopropyl-2-hydroxypropanoate ,O[C@H](CC1CC1)C(OC)=O,,,,,
3,Methyl (R)-3-cyclopropyl-2-(((trifluoromethyl)sulfonyl)oxy)propanoate ,O=C(OC)[C@@H](CC1CC1)OS(=O)(C(F)(F)F)=O,,,,,
,"tert-butyl (2-oxo-1,2-dihydropyridin-3-yl)carbamate",O=C1C(NC(OC(C)(C)C)=O)=CC=CN1,,,,,
4,Methyl 2-(3-((tert-butoxycarbonyl)amino)-2-oxopyridin-1(2H)-yl)-3-cyclopropylpropanoate ,O=C(OC)C(CC1CC1)N2C=CC=C(NC(OC(C)(C)C)=O)C2=O,,,,,
5,2-(3-((tert-Butoxycarbonyl)amino)-2-oxopyridin-1(2H)-yl)-3-cyclopropylpropanoic acid ,OC(C(CC1CC1)N2C=CC=C(NC(OC(C)(C)C)=O)C2=O)=O,,,,,
,"Dimethyl (2S,4R)-2-((tert-butoxycarbonyl)amino)-4-(cyanomethyl)pentanedioate ",O=C(OC)[C@@H](NC(OC(C)(C)C)=O)C[C@H](CC#N)C(OC)=O,,,,,
,Methyl (S)-2-((tert-butoxycarbonyl)amino)-3-((S)-2-oxopyrrolidin-3-yl)propanoate ,O=C(OC)[C@@H](NC(OC(C)(C)C)=O)C[C@H]1C(NCC1)=O,,,,,
,methyl (S)-2-amino-3-((S)-2-oxopyrrolidin-3-yl)propanoate hydrochloride,N[C@@H](C[C@@H]1CCNC1=O)C(OC)=O,,,,,
6,Methyl (S)-2-(2-(3-((tert-butoxycarbonyl)amino)-2-oxopyridin-1(2H)-yl)-3-cyclopropylpropanamido)-3-((S)-2-oxopyrrolidin-3-yl)propanoate ,O=C(N[C@@H](C[C@@H]1CCNC1=O)C(OC)=O)C(CC2CC2)N3C=CC=C(NC(OC(C)(C)C)=O)C3=O,,,,,
7,"tert-Butyl (1-(-3-cyclopropyl-1-(((S)-1-hydroxy-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)amino)-1-oxopropan-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)carbamate ",O=C(N[C@@H](C[C@@H]1CCNC1=O)CO)C(CC2CC2)N3C=CC=C(NC(OC(C)(C)C)=O)C3=O,,,,,
8,"tert-Butyl (1-(3-cyclopropyl-1-oxo-1-(((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)amino)propan-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)carbamate ",O=C(N[C@@H](C[C@@H]1CCNC1=O)C=O)C(CC2CC2)N3C=CC=C(NC(OC(C)(C)C)=O)C3=O,,,,,
9,(3S)-1-(Benzylamino)-3-(2-(3-((tert-butoxycarbonyl)amino)-2-oxopyridin-1(2H)-yl)-3-cyclopropylpropanamido)-1-oxo-4-((S)-2-oxopyrrolidin-3-yl)butan-2-yl acetate ,O=C(N[C@@H](C[C@@H]1CCNC1=O)C(C(NCC2=CC=CC=C2)=O)OC(C)=O)C(CC3CC3)N4C=CC=C(NC(OC(C)(C)C)=O)C4=O,,,,,
10,"tert-Butyl (1-(1-(((2S)-4-(benzylamino)-3-hydroxy-4-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-3-cyclopropyl-1-oxopropan-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)carbamate ",O=C(N[C@@H](C[C@@H]1CCNC1=O)C(C(NCC2=CC=CC=C2)=O)O)C(CC3CC3)N4C=CC=C(NC(OC(C)(C)C)=O)C4=O,,,,,
11,"tert-Butyl (1-(-1-(((S)-4-(benzylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-3-cyclopropyl-1-oxopropan-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)carbamate ",O=C(N[C@@H](C[C@@H]1CCNC1=O)C(C(NCC2=CC=CC=C2)=O)=O)C(CC3CC3)N4C=CC=C(NC(OC(C)(C)C)=O)C4=O,,,,,
12,"tert-Butyl (1-((R)-1-(((S)-4-(benzylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-3-cyclopropyl-1-oxopropan-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)carbamate",O=C(N[C@@H](C[C@@H]1CCNC1=O)C(C(NCC2=CC=CC=C2)=O)=O)[C@@H](CC3CC3)N4C=CC=C(NC(OC(C)(C)C)=O)C4=O,>5 µM,,,,
13,"tert-Butyl (1-((S)-1-(((S)-4-(benzylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-3-cyclopropyl-1-oxopropan-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)carbamate",O=C(N[C@@H](C[C@@H]1CCNC1=O)C(C(NCC2=CC=CC=C2)=O)=O)[C@H](CC3CC3)N4C=CC=C(NC(OC(C)(C)C)=O)C4=O,0.12 ± 0.03 μM,2.4 ± 0.7 μM ,1.3 µM (1.16-1.55),3.4 µM (1.58-5.03),0.84 µM (0.64-1.08) 
,Methyl (R)-3-cyclopropyl-2-((triisopropylsilyl)oxy)propanoate ,O=C(OC)[C@H](O[Si](C(C)C)(C(C)C)C(C)C)CC1CC1,,,,,
14,(R)-3-Cyclopropyl-2-((triisopropylsilyl)oxy)propanoic acid ,O=C(O)[C@H](O[Si](C(C)C)(C(C)C)C(C)C)CC1CC1,,,,,
15,Methyl (S)-2-((R)-3-cyclopropyl-2-((triisopropylsilyl)oxy)propanamido)-3-((S)-2-oxopyrrolidin-3-yl)propanoate ,O=C(OC)[C@@H](NC([C@H](O[Si](C(C)C)(C(C)C)C(C)C)CC1CC1)=O)C[C@H]2C(NCC2)=O,,,,,
16,Methyl (S)-2-((R)-3-cyclopropyl-2-hydroxypropanamido)-3-((S)-2-oxopyrrolidin-3-yl)propanoate ,O=C(OC)[C@@H](NC([C@H](O)CC1CC1)=O)C[C@H]2C(NCC2)=O,,,,,