2021-04-04 2021-04-19 2021-05-10 2021-06-07 2021-06-28 2021-07-19 2021-08-02 2021-08-09 2021-08-16 2021-08-23 2021-08-30 2021-09-01 2021-09-08 2021-09-13 2021-09-20 2021-10-04 2021-10-18 2021-10-26 2021-11-08 2021-11-15 2021-11-22 2021-11-29 2021-12-06 2021-12-13 2021-12-27 2021-12-29 2022-01-03 2022-01-18 2022-01-25 2022-02-07 2022-02-14 2022-02-23 2022-02-28 2022-03-07 2022-03-14 Covariant Abundance Abundance Abundance Abundance Abundance Abundance Abundance Abundance Abundance Abundance Abundance Abundance Abundance Abundance Abundance Abundance Abundance Abundance Abundance Abundance Abundance Abundance Abundance Abundance Abundance Abundance Abundance Abundance Abundance Abundance Abundance Abundance Abundance Abundance Abundance 1241-insertA(414fs) A1250C(K417T) T1355G(L452R) C1433A(T478K) 0.002 1241-insertA(414fs) A1268C(Y423S) T1355G(L452R) C1433A(T478K) 0.004 1241-insertA(414fs) T1355G(L452R) C1433A(T478K) 0.162 1241-insertA(414fs) T1355G(L452R) C1433A(T478K) G1444T(G482C) 0.004 1241-insertA(414fs) T1355G(L452R) C1433A(T478K) G1507T(V503F) 0.001 1241-insertA(414fs) T1355G(L452R) T1405G(S469A) C1433A(T478K) 0.002 A1214C(D405A) T1355G(L452R) C1433A(T478K) 0.006 A1214G(D405G) T1355G(L452R) C1433A(T478K) 0.014 A1217-1217del(406fs) 0.038 A1217-1217del(406fs) G1430A(S477N) 0.003 A1217-1217del(406fs) T1355G(L452R) C1431T(S477S) C1433A(T478K) 0.002 0.001 A1217-1217del(406fs) T1355G(L452R) C1433A(T478K) 0.003 0.003 0.001 0.002 0.002 0.003 0.003 0.0015 0.001 A1217-1217del(406fs) T1355G(L452R) GGAAGTCTAATCTCAAACCTTTTGAGAGAGATATT1370-1404del(457fs) C1433A(T478K) 0.004 A1217-1217del(406fs) T1355G(L452R) T1382C(L461P) C1433A(T478K) 0.002 A1217C(E406A) G1251T(K417N) T1263C(Y421Y) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) G1649N(G550?) 0.003 0.003 A1217G(E406G) G1251T(K417N) T1263C(Y421Y) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) G1649N(G550?) 0.006 0.002 A1217G(E406G) G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.006 A1218T(E406D) A1250C(K417T) T1273G(L425V) A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) TAT1345-1347CGT(Y449R) T1355G(L452R) T1380G(N460K) GAA1450-1452del(E484del) T1456G(F486V) A1479C(Q493H) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) G1510A(G504S) T1513C(Y505H) T1557A(H519Q) 0.019 A1218T(E406D) G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.0033333333333333335 A1222-1222del(408fs) G1430A(S477N) 0.001 A1222-1222del(408fs) T1355G(L452R) C1433A(T478K) 0.001 0.001 0.001 0.0005 A1224C(R408S) A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) GTT1333-1335CGT(V445R) G1337A(G446D) TAT1345-1347CGT(Y449R) T1355A(L452Q) A1358T(Y453F) G1365T(L455F) T1368A(F456L) T1380G(N460K) T1401C(D467D) G1430A(S477N) C1433G(T478R) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) GGT1510-1512GAG(G504E) T1513C(Y505H) T1557A(H519Q) C1640A(T547K) 0.007333333333333333 A1224C(R408S) A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) GTT1333-1335CGT(V445R) G1337A(G446D) TAT1345-1347CGT(Y449R) T1355A(L452Q) A1358T(Y453F) G1365T(L455F) T1368A(F456L) T1380G(N460K) T1401C(D467D) G1430A(S477N) C1433G(T478R) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) GGT1510-1512GAG(G504E) T1513C(Y505H) T1557A(H519Q) C1682A(P561H) A1703G(D568G) 0.02766666666666667 A1224C(R408S) AAG1249-1251ATT(K417I) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.014 A1224C(R408S) C1230T(I410I) G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.047 0.042666666666666665 A1224C(R408S) G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) A1518C(Q506H) C1640A(T547K) 0.012 A1224C(R408S) G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) A1605G(K535K) C1640A(T547K) 0.025 A1224C(R408S) G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1516A(Q506K) C1640A(T547K) 0.013 A1224C(R408S) G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.011000000000000001 A1224C(R408S) G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) A1717G(T573A) 0.024 A1241G(Q414R) A1243C(T415P) T1355G(L452R) C1433A(T478K) T1722C(D574D) 0.003 A1241G(Q414R) A1243G(T415A) T1355G(L452R) C1433A(T478K) T1722C(D574D) 0.012 A1241G(Q414R) A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) T1334G(V445G) TAT1345-1347CGT(Y449R) T1355A(L452Q) T1380G(N460K) C1433A(T478K) T1722C(D574D) 0.002 A1241G(Q414R) A1310C(N437T) T1355G(L452R) C1433A(T478K) T1722C(D574D) 0.003 A1241G(Q414R) A1310G(N437S) T1355G(L452R) C1433A(T478K) T1722C(D574D) 0.012 A1241G(Q414R) T1355G(L452R) C1433A(T478K) 0.016 A1241G(Q414R) T1355G(L452R) C1433A(T478K) T1448A(V483D) T1722C(D574D) 0.006 A1241G(Q414R) T1355G(L452R) C1433A(T478K) T1448C(V483A) T1722C(D574D) 0.004 A1241G(Q414R) T1355G(L452R) C1433A(T478K) T1722A(D574E) 0.004 A1241G(Q414R) T1355G(L452R) C1433A(T478K) T1722C(D574D) 0.583 A1241T(Q414L) G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.026 A1243T(T415S) A1250C(K417T) A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) T1334G(V445G) TAT1345-1347CGT(Y449R) T1355A(L452Q) T1380G(N460K) G1430A(S477N) C1433G(T478R) A1451T(E484V) TTT1456-1458CCT(F486P) TTT1468-1470CCT(F490P) A1478G(Q493R) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) 1512-insertA(504fs) T1513C(Y505H) T1557A(H519Q) 0.017 A1250C(K417T) A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) T1334C(V445A) TAT1345-1347CGT(Y449R) T1355A(L452Q) C1433A(T478K) 0.003 A1250C(K417T) A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) T1334C(V445A) TAT1345-1347CGT(Y449R) T1355A(L452Q) T1380G(N460K) C1433A(T478K) 0.006 A1250C(K417T) A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) T1334C(V445A) TAT1345-1347CGT(Y449R) T1355A(L452Q) T1380G(N460K) G1430A(S477N) C1433A(T478K) A1451T(E484V) T1456C(F486L) T1469C(F490S) T1480A(S494T) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) G1511A(G504D) T1513C(Y505H) T1557A(H519Q) 0.002 A1250C(K417T) A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) T1334C(V445A) TAT1345-1347CGT(Y449R) T1355A(L452Q) T1380G(N460K) G1430A(S477N) C1433A(T478K) A1451T(E484V) T1457C(F486S) T1469C(F490S) T1480A(S494T) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) G1511A(G504D) T1513C(Y505H) T1557A(H519Q) 0.001 A1250C(K417T) A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) T1334C(V445A) TAT1345-1347CGT(Y449R) T1355A(L452Q) T1380G(N460K) G1430A(S477N) C1433A(T478K) A1451T(E484V) TTT1456-1458CCT(F486P) G1463T(C488F) T1469C(F490S) T1480A(S494T) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) G1511A(G504D) T1513C(Y505H) T1557A(H519Q) 0.004 A1250C(K417T) A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) T1334C(V445A) TAT1345-1347CGT(Y449R) T1355A(L452Q) T1380G(N460K) G1430A(S477N) C1433A(T478K) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) T1480A(S494T) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) G1511A(G504D) T1513A(Y505N) T1557A(H519Q) 0.011 A1250C(K417T) A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) T1334C(V445A) TAT1345-1347CGT(Y449R) T1355A(L452Q) T1380G(N460K) G1430A(S477N) C1433A(T478K) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) T1480A(S494T) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) G1511A(G504D) T1513C(Y505H) A1525C(R509R) T1557A(H519Q) 0.003 A1250C(K417T) A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) T1334C(V445A) TAT1345-1347CGT(Y449R) T1355A(L452Q) T1380G(N460K) G1430A(S477N) C1433A(T478K) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) T1480A(S494T) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) G1511A(G504D) T1513C(Y505H) T1545G(F515L) T1557A(H519Q) 0.003 A1250C(K417T) A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) T1334C(V445A) TAT1345-1347CGT(Y449R) T1355A(L452Q) T1380G(N460K) G1430A(S477N) C1433A(T478K) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) T1480A(S494T) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) G1511A(G504D) T1513C(Y505H) T1557A(H519Q) 0.24 A1250C(K417T) A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) T1334C(V445A) TAT1345-1347CGT(Y449R) T1355A(L452Q) T1380G(N460K) G1430A(S477N) C1433A(T478K) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) T1480A(S494T) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) G1511C(G504A) T1513C(Y505H) T1557A(H519Q) 0.002 A1250C(K417T) A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) T1334C(V445A) TAT1345-1347CGT(Y449R) T1355A(L452Q) T1380G(N460K) G1430A(S477N) C1433A(T478K) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) T1480A(S494T) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) G1511T(G504V) T1513C(Y505H) T1557A(H519Q) 0.013 A1250C(K417T) A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) T1334C(V445A) TAT1345-1347CGT(Y449R) T1355A(L452Q) T1380G(N460K) G1430A(S477N) C1433A(T478K) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) T1480A(S494T) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) GGT1510-1512GAG(G504E) T1513C(Y505H) T1557A(H519Q) 0.001 A1250C(K417T) A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) T1334C(V445A) TAT1345-1347CGT(Y449R) T1355A(L452Q) T1380G(N460K) G1430A(S477N) C1433A(T478K) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) T1480A(S494T) GGT1486-1488TTT(G496F) CAA1492-1494TAC(Q498Y) A1502C(N501T) G1511A(G504D) T1513C(Y505H) T1557A(H519Q) 0.002 A1250C(K417T) A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) T1334C(V445A) TAT1345-1347CGT(Y449R) T1355A(L452Q) T1380G(N460K) G1430A(S477N) C1433A(T478K) A1451T(E484V) TTT1456-1458CCT(F486P) T1480A(S494T) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) G1511A(G504D) T1513C(Y505H) T1557A(H519Q) 0.002 A1250C(K417T) A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) T1334G(V445G) TAT1345-1347CGT(Y449R) T1355A(L452Q) T1380G(N460K) C1433A(T478K) 0.002 A1250C(K417T) A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) T1334G(V445G) TAT1345-1347CGT(Y449R) T1355A(L452Q) T1380G(N460K) C1433A(T478K) T1722C(D574D) 0.003 A1250C(K417T) A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) T1334G(V445G) TAT1345-1347CGT(Y449R) T1355A(L452Q) T1380G(N460K) G1430A(S477N) C1433A(T478K) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) A1478G(Q493R) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) G1511A(G504D) T1513C(Y505H) 0.001 A1250C(K417T) A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) T1334G(V445G) TAT1345-1347CGT(Y449R) T1355A(L452Q) T1380G(N460K) G1430A(S477N) C1433A(T478K) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) A1478G(Q493R) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) G1511A(G504D) T1513C(Y505H) T1557A(H519Q) 0.042 A1250C(K417T) A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) T1334G(V445G) TAT1345-1347CGT(Y449R) T1355A(L452Q) T1380G(N460K) G1430A(S477N) C1433G(T478R) A1451T(E484V) TTT1456-1458CCT(F486P) TTT1468-1470CCT(F490P) A1478G(Q493R) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) 1512-insertA(504fs) T1513C(Y505H) T1557A(H519Q) 0.159 A1250C(K417T) A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) T1334G(V445G) TAT1345-1347CGT(Y449R) T1355A(L452Q) T1380G(N460K) G1430A(S477N) C1433G(T478R) A1451T(E484V) TTT1456-1458CCT(F486P) TTT1468-1470CCT(F490P) A1478G(Q493R) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) 1512-insertA(504fs) T1513C(Y505H) T1722C(D574D) 0.002 A1250C(K417T) A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) T1334G(V445G) TAT1345-1347CGT(Y449R) T1355A(L452Q) T1380G(N460K) G1430A(S477N) C1433G(T478R) A1451T(E484V) TTT1456-1458CCT(F486P) TTT1468-1470CCT(F490P) A1478G(Q493R) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) G1511A(G504D) T1513C(Y505H) T1557A(H519Q) 0.0555 A1250C(K417T) A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) T1334G(V445G) TAT1345-1347CGT(Y449R) T1355A(L452Q) T1380G(N460K) G1430A(S477N) C1433G(T478R) A1451T(E484V) TTT1456-1458CCT(F486P) TTT1468-1470CCT(F490P) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) G1511A(G504D) T1513C(Y505H) T1557A(H519Q) 0.011 A1250C(K417T) A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) T1334G(V445G) TAT1345-1347CGT(Y449R) T1355A(L452Q) T1380G(N460K) G1430A(S477N) C1433G(T478R) T1722C(D574D) 0.003 A1250C(K417T) C1317A(N439K) CTT1321-1323CGC(L441R) G1332T(K444N) T1334C(V445A) TAT1345-1347CGT(Y449R) T1355A(L452Q) A1358T(Y453F) T1380G(N460K) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.003 A1250C(K417T) C1317A(N439K) CTT1321-1323CGC(L441R) G1332T(K444N) T1334C(V445A) TAT1345-1347CGT(Y449R) T1355A(L452Q) A1358T(Y453F) T1380G(N460K) G1430A(S477N) C1433A(T478K) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) G1511A(G504D) T1513C(Y505H) T1557A(H519Q) 0.032 A1250C(K417T) C1317A(N439K) CTT1321-1323CGC(L441R) G1332T(K444N) T1334C(V445A) TAT1345-1347CGT(Y449R) T1355A(L452Q) A1358T(Y453F) T1380G(N460K) G1430A(S477N) C1433G(T478R) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) G1511A(G504D) T1513C(Y505H) T1557A(H519Q) 0.037 A1250C(K417T) C1317A(N439K) CTT1321-1323CGC(L441R) G1332T(K444N) T1334C(V445A) TAT1345-1347CGT(Y449R) T1355A(L452Q) T1380G(N460K) G1430A(S477N) C1433A(T478K) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) G1511A(G504D) T1513C(Y505H) T1557A(H519Q) 0.018 A1250C(K417T) C1317A(N439K) CTT1321-1323CGC(L441R) G1332T(K444N) TAT1345-1347CGT(Y449R) T1355A(L452Q) A1358T(Y453F) T1380G(N460K) T1401C(D467D) G1430A(S477N) C1433A(T478K) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1498T(T500S) A1502C(N501T) G1511A(G504D) T1513C(Y505H) T1557A(H519Q) 0.05 A1250C(K417T) C1317A(N439K) T1323C(L441L) G1332T(K444N) GTT1333-1335AAT(V445N) TAT1345-1347CGT(Y449R) T1355A(L452Q) T1380G(N460K) G1430A(S477N) C1433G(T478R) A1451T(E484V) TTT1456-1458CCT(F486P) TTT1468-1470CAT(F490H) T1480A(S494T) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) GGT1510-1512GAG(G504E) T1513C(Y505H) C1516A(Q506K) T1557A(H519Q) C1682A(P561H) 0.1 A1250C(K417T) C1317A(N439K) T1323C(L441L) G1332T(K444N) TAT1345-1347CGT(Y449R) G1430A(S477N) 0.004 A1250C(K417T) C1317A(N439K) T1323C(L441L) G1332T(K444N) TAT1345-1347CGT(Y449R) T1355G(L452R) T1380G(N460K) G1430A(S477N) 0.014 A1250C(K417T) C1317A(N439K) T1323C(L441L) G1332T(K444N) TAT1345-1347CGT(Y449R) T1355G(L452R) T1380G(N460K) G1430A(S477N) GAA1450-1452del(E484del) T1456G(F486V) T1480A(S494T) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) G1511A(G504D) T1513C(Y505H) T1557A(H519Q) T1569G(T523T) 0.248 A1250C(K417T) C1383T(L461L) A1432T(T478S) G1450A(E484K) A1501T(N501Y) 0.0095 A1250C(K417T) C1383T(L461L) G1450A(E484K) A1501T(N501Y) 0.116 A1250C(K417T) G1430A(S477N) 0.013 A1250C(K417T) G1450A(E484K) 0.003 A1250C(K417T) T1273G(L425V) A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) TAT1345-1347CGT(Y449R) T1355G(L452R) T1380G(N460K) G1430A(S477N) GAA1450-1452del(E484del) T1456G(F486V) T1480A(S494T) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) G1511A(G504D) T1513C(Y505H) T1557A(H519Q) T1569G(T523T) 0.018 A1250C(K417T) T1273G(L425V) A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) TAT1345-1347CGT(Y449R) T1355G(L452R) T1380G(N460K) GAA1450-1452del(E484del) T1456G(F486V) A1479C(Q493H) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) G1510A(G504S) T1513C(Y505H) T1557A(H519Q) 0.103 A1250C(K417T) T1273G(L425V) A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) TAT1345-1347CGT(Y449R) T1355G(L452R) T1380G(N460K) GAA1450-1452del(E484del) T1456G(F486V) A1479C(Q493H) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) G1510A(G504S) T1513C(Y505H) T1557C(H519H) 0.006 A1250C(K417T) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.029 A1283C(D428A) T1355G(L452R) C1433A(T478K) 0.004333333333333334 A1283G(D428G) T1355G(L452R) C1431T(S477S) C1433A(T478K) T1455C(G485G) 0.0029999999999999996 A1283G(D428G) T1355G(L452R) C1433A(T478K) 0.0033333333333333335 A1283G(D428G) T1355G(L452R) C1433A(T478K) T1455A(G485G) 0.0016666666666666668 A1288C(T430P) T1355G(L452R) C1433A(T478K) 0.004666666666666667 A1288G(T430A) T1355G(L452R) C1431T(S477S) C1433A(T478K) 0.005666666666666667 A1288G(T430A) T1355G(L452R) C1433A(T478K) 0.005666666666666667 A1290G(T430T) T1355G(L452R) C1433A(T478K) 0.0005 A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) GTT1333-1335CGT(V445R) G1337A(G446D) TAT1345-1347CGT(Y449R) T1355A(L452Q) A1358T(Y453F) G1365T(L455F) T1368A(F456L) T1380G(N460K) T1401C(D467D) G1426A(G476S) G1430A(S477N) C1433G(T478R) A1451G(E484G) TTT1456-1458CCT(F486P) T1469C(F490S) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) GGT1510-1512GAG(G504E) T1513C(Y505H) T1557A(H519Q) C1682A(P561H) 0.004 A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) GTT1333-1335CGT(V445R) G1337A(G446D) TAT1345-1347CGT(Y449R) T1355A(L452Q) A1358T(Y453F) G1365T(L455F) T1368A(F456L) T1380G(N460K) T1401C(D467D) G1426A(G476S) G1430A(S477N) C1433G(T478R) A1451T(E484V) T1457C(F486S) T1469C(F490S) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) GGT1510-1512GAG(G504E) T1513C(Y505H) T1557A(H519Q) C1682A(P561H) 0.002 A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) GTT1333-1335CGT(V445R) G1337A(G446D) TAT1345-1347CGT(Y449R) T1355A(L452Q) A1358T(Y453F) G1365T(L455F) T1368A(F456L) T1380G(N460K) T1401C(D467D) G1426A(G476S) G1430A(S477N) C1433G(T478R) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) G1487T(G496V) C1491T(F497F) CAA1492-1494TAC(Q498Y) A1502C(N501T) GGT1510-1512GAG(G504E) T1513C(Y505H) T1557A(H519Q) C1682A(P561H) 0.002 A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) GTT1333-1335CGT(V445R) G1337A(G446D) TAT1345-1347CGT(Y449R) T1355A(L452Q) A1358T(Y453F) G1365T(L455F) T1368A(F456L) T1380G(N460K) T1401C(D467D) G1426A(G476S) G1430A(S477N) C1433G(T478R) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) GGT1510-1512GAG(G504E) T1513A(Y505N) C1516A(Q506K) T1557A(H519Q) C1682A(P561H) 0.041 A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) GTT1333-1335CGT(V445R) G1337A(G446D) TAT1345-1347CGT(Y449R) T1355A(L452Q) A1358T(Y453F) G1365T(L455F) T1368A(F456L) T1380G(N460K) T1401C(D467D) G1426A(G476S) G1430A(S477N) C1433G(T478R) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) GGT1510-1512GAG(G504E) T1513A(Y505N) T1557A(H519Q) C1682A(P561H) 0.027 A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) GTT1333-1335CGT(V445R) G1337A(G446D) TAT1345-1347CGT(Y449R) T1355A(L452Q) A1358T(Y453F) G1365T(L455F) T1368A(F456L) T1380G(N460K) T1401C(D467D) G1426A(G476S) G1430A(S477N) C1433G(T478R) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) GGT1510-1512GAG(G504E) T1513C(Y505H) A1518C(Q506H) T1557A(H519Q) C1682A(P561H) 0.005 A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) GTT1333-1335CGT(V445R) G1337A(G446D) TAT1345-1347CGT(Y449R) T1355A(L452Q) A1358T(Y453F) G1365T(L455F) T1368A(F456L) T1380G(N460K) T1401C(D467D) G1426A(G476S) G1430A(S477N) C1433G(T478R) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) GGT1510-1512GAG(G504E) T1513C(Y505H) C1520A(P507Q) T1557A(H519Q) C1682A(P561H) 0.002 A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) GTT1333-1335CGT(V445R) G1337A(G446D) TAT1345-1347CGT(Y449R) T1355A(L452Q) A1358T(Y453F) G1365T(L455F) T1368A(F456L) T1380G(N460K) T1401C(D467D) G1426A(G476S) G1430A(S477N) C1433G(T478R) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) GGT1510-1512GAG(G504E) T1513C(Y505H) T1542G(S514S) T1557A(H519Q) C1682A(P561H) 0.002 A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) GTT1333-1335CGT(V445R) G1337A(G446D) TAT1345-1347CGT(Y449R) T1355A(L452Q) A1358T(Y453F) G1365T(L455F) T1368A(F456L) T1380G(N460K) T1401C(D467D) G1426A(G476S) G1430A(S477N) C1433G(T478R) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) GGT1510-1512GAG(G504E) T1513C(Y505H) T1543G(F515V) T1557A(H519Q) C1682A(P561H) 0.006 A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) GTT1333-1335CGT(V445R) G1337A(G446D) TAT1345-1347CGT(Y449R) T1355A(L452Q) A1358T(Y453F) G1365T(L455F) T1368A(F456L) T1380G(N460K) T1401C(D467D) G1426A(G476S) G1430A(S477N) C1433G(T478R) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) GGT1510-1512GAG(G504E) T1513C(Y505H) T1557A(H519Q) C1559A(A520E) C1682A(P561H) 0.006 A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) GTT1333-1335CGT(V445R) G1337A(G446D) TAT1345-1347CGT(Y449R) T1355A(L452Q) A1358T(Y453F) G1365T(L455F) T1368A(F456L) T1380G(N460K) T1401C(D467D) G1426A(G476S) G1430A(S477N) C1433G(T478R) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) GGT1510-1512GAG(G504E) T1513C(Y505H) T1557A(H519Q) C1682A(P561H) 0.775 A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) GTT1333-1335CGT(V445R) G1337A(G446D) TAT1345-1347CGT(Y449R) T1355A(L452Q) A1358T(Y453F) G1365T(L455F) T1368A(F456L) T1380G(N460K) T1401C(D467D) G1426A(G476S) G1430A(S477N) C1433G(T478R) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) GGT1510-1512GTG(G504V) T1513C(Y505H) T1557A(H519Q) C1682A(P561H) 0.002 A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) GTT1333-1335CGT(V445R) G1337A(G446D) TAT1345-1347CGT(Y449R) T1355A(L452Q) A1358T(Y453F) G1365T(L455F) T1368A(F456L) T1380G(N460K) T1401C(D467D) G1426A(G476S) G1430A(S477N) C1433G(T478R) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) T1512G(G504G) T1513C(Y505H) T1557A(H519Q) C1682A(P561H) 0.016 A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) GTT1333-1335CGT(V445R) G1337A(G446D) TAT1345-1347CGT(Y449R) T1355A(L452Q) A1358T(Y453F) G1365T(L455F) T1368A(F456L) T1380G(N460K) T1401C(D467D) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.0013333333333333333 A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) GTT1333-1335CGT(V445R) G1337A(G446D) TAT1345-1347CGT(Y449R) T1355A(L452Q) A1358T(Y453F) G1365T(L455F) T1368A(F456L) T1380G(N460K) T1401C(D467D) G1430A(S477N) C1433G(T478R) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) GGT1510-1512GAG(G504E) T1513C(Y505H) C1640A(T547K) 0.0023333333333333335 A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) T1334C(V445A) TAT1345-1347CGT(Y449R) T1355G(L452R) C1433A(T478K) 0.014 A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) T1334C(V445A) TAT1345-1347CGT(Y449R) T1355G(L452R) T1380G(N460K) C1433A(T478K) 0.004 A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) T1334G(V445G) TAT1345-1347CGT(Y449R) T1355A(L452Q) C1433A(T478K) 0.0015 A1331C(K444T) T1355G(L452R) C1433A(T478K) 0.0006666666666666666 A1378-1378del(460fs) 0.283 A1432T(T478S) A1501T(N501Y) C1709A(A570D) 0.011 A1501T(N501Y) 0.002 A1501T(N501Y) C1709A(A570D) 0.426 0.16099999999999998 A1501T(N501Y) G1587A(K529K) 0.009 A1501T(N501Y) G1587A(K529K) C1709A(A570D) 0.0115 A1501T(N501Y) T1627C(F543L) C1709A(A570D) 0.134 A1525C(R509R) 0.028 A1548C(E516D) 0.045 A1595C(N532T) 0.026 A1703G(D568G) 0.071 A709-709del(237fs) G1016A(G339D) G1037A(R346K) TCC1111-1113CTC(S371L) T1117C(S373P) C1124T(S375F) 0.0013333333333333333 A716-716del(239fs) G1016A(G339D) G1037A(R346K) TCC1111-1113CTC(S371L) T1117C(S373P) C1124T(S375F) 0.0016666666666666668 A732C(L244F) T822C(T274T) G1016A(G339D) TCC1111-1113CTC(S371L) T1117C(S373P) C1124T(S375F) C1196A(S399*) 0.005333333333333333 A813C(Q271H) G1016A(G339D) G1037A(R346K) TCC1111-1113CTC(S371L) T1117C(S373P) C1124T(S375F) 0.0026666666666666666 A813G(Q271Q) G1016A(G339D) G1037A(R346K) TCC1111-1113CTC(S371L) T1117C(S373P) C1124T(S375F) 0.005666666666666667 A828C(L276L) G1016A(G339D) G1037A(R346K) TCC1111-1113CTC(S371L) T1117C(S373P) C1124T(S375F) 0.0036666666666666666 A828G(L276L) G1016A(G339D) G1037A(R346K) TCC1111-1113CTC(S371L) T1117C(S373P) C1124T(S375F) 0.004666666666666667 C1221-1221del(407fs) G1430A(S477N) 0.001 C1221-1221del(407fs) T1355G(L452R) C1433A(T478K) 0.001 0.001 0.001 0.0005 C1221T(V407V) G1239T(G413G) T1355G(L452R) C1433A(T478K) 0.019 C1221T(V407V) G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) A1670G(K557R) 0.0033333333333333335 C1225T(Q409*) A1250C(K417T) A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) T1334C(V445A) TAT1345-1347CGT(Y449R) T1355A(L452Q) T1380G(N460K) G1430A(S477N) C1433A(T478K) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) T1480A(S494T) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) G1511A(G504D) T1513C(Y505H) T1557A(H519Q) 0.019 C1225T(Q409*) T1355G(L452R) T1382C(L461P) C1433A(T478K) 0.016 C1232A(A411D) T1355G(L452R) C1433A(T478K) 0.002 C1244A(T415N) T1355G(L452R) C1433A(T478K) 0.002 C1244T(T415I) G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.0036666666666666666 0.025 C1244T(T415I) T1355G(L452R) C1431T(S477S) C1433A(T478K) 0.009 C1276T(P426S) T1355G(L452R) C1433A(T478K) 0.188 C1276T(P426S) T1355G(L452R) C1433A(T478K) G1445T(G482V) 0.007 C1276T(P426S) T1355G(L452R) C1433A(T478K) T1693C(F565L) 0.015 C1296T(C432C) 0.352 C1317A(N439K) CTT1321-1323CGC(L441R) AAG1330-1332AGT(K444S) T1334C(V445A) TAT1345-1347CGT(Y449R) T1355A(L452Q) A1358T(Y453F) T1364G(L455W) T1368G(F456L) T1380G(N460K) T1401C(D467D) G1430A(S477N) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) G1487T(G496V) CAA1492-1494TAC(Q498Y) C1495T(P499S) AAT1501-1503GCT(N501A) G1511A(G504D) T1513C(Y505H) C1640A(T547K) 0.014 C1317A(N439K) CTT1321-1323CGC(L441R) AAG1330-1332AGT(K444S) T1334C(V445A) TAT1345-1347CGT(Y449R) T1355A(L452Q) A1358T(Y453F) T1364G(L455W) T1368G(F456L) T1380G(N460K) T1401C(D467D) G1430A(S477N) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) G1487T(G496V) CAA1492-1494TAC(Q498Y) C1495T(P499S) AAT1501-1503GCT(N501A) G1511A(G504D) T1513C(Y505H) T1557A(H519Q) 0.079 C1317A(N439K) CTT1321-1323CGC(L441R) AAG1330-1332AGT(K444S) T1334C(V445A) TAT1345-1347CGT(Y449R) T1355A(L452Q) A1358T(Y453F) T1364G(L455W) T1368G(F456L) T1380G(N460K) T1401C(D467D) G1430A(S477N) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) G1487T(G496V) CAA1492-1494TAC(Q498Y) C1495T(P499S) AAT1501-1503GCT(N501A) G1511A(G504D) T1513C(Y505H) T1557A(H519Q) T1694A(F565Y) 0.061 C1317A(N439K) CTT1321-1323CGC(L441R) AAG1330-1332AGT(K444S) T1334C(V445A) TAT1345-1347CGT(Y449R) T1355A(L452Q) A1358T(Y453F) T1364G(L455W) T1368G(F456L) T1380G(N460K) T1401C(D467D) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) T1480C(S494P) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.001 C1433A(T478K) 0.001 0.042 0.005 0.005 C1467T(Y489Y) A1501T(N501Y) C1709A(A570D) 0.044 C1524A(Y508*) 0.188 0.006 C1709A(A570D) 0.003 0.003 CTG1354-1356TGG(L452W) C1433A(T478K) 0.001 G1005T(L335F) G1016A(G339D) G1037A(R346K) TCC1111-1113CTC(S371L) T1117C(S373P) C1124T(S375F) 0.0026666666666666666 G1007T(C336F) G1016A(G339D) G1037A(R346K) TCC1111-1113CTC(S371L) T1117C(S373P) C1124T(S375F) 0.001 G1016A(G339D) G1037A(R346K) TCC1111-1113CTC(S371L) C1115A(A372E) T1117C(S373P) C1124T(S375F) 0.001 G1016A(G339D) G1037A(R346K) TCC1111-1113CTC(S371L) T1117C(S373P) C1124T(S375F) 0.27566666666666667 G1016A(G339D) G1037A(R346K) TCC1111-1113CTC(S371L) T1117C(S373P) C1124T(S375F) A1236T(P412P) 0.0013333333333333333 G1016A(G339D) G1037A(R346K) TCC1111-1113CTC(S371L) T1117C(S373P) C1124T(S375F) A1243G(T415A) 0.0029999999999999996 G1016A(G339D) G1037A(R346K) TCC1111-1113CTC(S371L) T1117C(S373P) C1124T(S375F) A1243T(T415S) 0.0029999999999999996 G1016A(G339D) G1037A(R346K) TCC1111-1113CTC(S371L) T1117C(S373P) C1124T(S375F) C1151A(P384H) 0.0016666666666666668 G1016A(G339D) G1037A(R346K) TCC1111-1113CTC(S371L) T1117C(S373P) C1124T(S375F) C1178A(T393N) 0.001 G1016A(G339D) T1024G(F342V) G1037A(R346K) TCC1111-1113CTC(S371L) T1117C(S373P) C1124T(S375F) 0.001 G1216-1216del(406fs) 0.026 G1216-1216del(406fs) G1430A(S477N) 0.002 G1216-1216del(406fs) T1355G(L452R) C1431T(S477S) C1433A(T478K) 0.001 G1216-1216del(406fs) T1355G(L452R) C1433A(T478K) 0.003 0.002 0.001 0.002 0.002 0.001 0.002 0.001 0.0006666666666666666 G1216-1216del(406fs) T1355G(L452R) T1382C(L461P) C1433A(T478K) 0.002 G1219-1219del(407fs) G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.002 0.002 G1219-1219del(407fs) G1430A(S477N) 0.001 G1231A(A411T) G1251T(K417N) T1266C(N422N) T1320G(N440K) G1336A(G446S) G1340C(G447A) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.036 G1237A(G413R) T1355G(L452R) C1433A(T478K) 0.015 G1239C(G413G) G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.004 G1239T(G413G) 1342-insertA(448fs) T1355G(L452R) T1389-1389del(463fs) C1433A(T478K) 0.018 G1239T(G413G) C1244T(T415I) T1355G(L452R) C1433A(T478K) C1715T(T572I) 0.009333333333333334 G1239T(G413G) G1339A(G447S) T1355G(L452R) C1433A(T478K) C1715T(T572I) 0.009666666666666667 G1239T(G413G) T1355G(L452R) C1433A(T478K) 0.486 0.082 0.163 0.0006666666666666666 G1239T(G413G) T1355G(L452R) C1433A(T478K) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) G1511A(G504D) T1513C(Y505H) T1557A(H519Q) 0.004 G1239T(G413G) T1355G(L452R) C1433A(T478K) A1527G(R509R) 0.002 G1239T(G413G) T1355G(L452R) C1433A(T478K) A1619G(N540S) 0.016 G1239T(G413G) T1355G(L452R) C1433A(T478K) A1692T(Q564H) 0.022 G1239T(G413G) T1355G(L452R) C1433A(T478K) C1524A(Y508*) 0.003 G1239T(G413G) T1355G(L452R) C1433A(T478K) C1559A(A520E) 0.002 G1239T(G413G) T1355G(L452R) C1433A(T478K) C1715T(T572I) 0.049666666666666665 G1239T(G413G) T1355G(L452R) C1433A(T478K) G1507T(V503F) 0.003 G1239T(G413G) T1355G(L452R) C1433A(T478K) G1528T(V510L) 0.002 G1239T(G413G) T1355G(L452R) C1433A(T478K) G1534T(V512L) 0.002 G1239T(G413G) T1355G(L452R) C1433A(T478K) T1469C(F490S) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) G1511A(G504D) T1513C(Y505H) T1557A(H519Q) 0.002 G1239T(G413G) T1355G(L452R) C1433A(T478K) T1512G(G504G) 0.01 G1239T(G413G) T1355G(L452R) C1433A(T478K) T1513G(Y505D) 0.002 G1239T(G413G) T1355G(L452R) C1433A(T478K) T1529G(V510G) 0.002 G1239T(G413G) T1355G(L452R) C1433A(T478K) T1542-1542del(514fs) 0.019 G1239T(G413G) T1355G(L452R) C1433A(T478K) T1590C(S530S) 0.023 G1239T(G413G) T1355G(L452R) C1433A(T478K) T1719-1719del(573fs) G1720C(D574H) 0.016 G1239T(G413G) T1355G(L452R) C1433A(T478K) T1722C(D574D) 0.011 G1239T(G413G) T1355G(L452R) C1433A(T478K) T1731A(R577R) 0.022 G1239T(G413G) T1355G(L452R) T1380G(N460K) G1430A(S477N) C1433A(T478K) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) G1511A(G504D) T1513C(Y505H) T1557A(H519Q) 0.011 G1247A(G416E) T1355G(L452R) C1433A(T478K) T1722C(D574D) 0.203 G1247C(G416A) T1355G(L452R) C1433A(T478K) T1722C(D574D) 0.002 G1251T(K417N) 0.03833333333333334 G1251T(K417N) A1290C(T430T) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.002 G1251T(K417N) A1290G(T430T) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.023 G1251T(K417N) A1302G(I434M) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.005 G1251T(K417N) A1316C(N439T) T1320G(N440K) G1336A(G446S) A1402T(I468F) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.004 G1251T(K417N) A1316C(N439T) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.005 G1251T(K417N) A1316G(N439S) T1320G(N440K) G1336A(G446S) A1402T(I468F) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.001 G1251T(K417N) A1316G(N439S) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.015 0.012 0.005 G1251T(K417N) C1256T(A419V) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) A1705G(I569V) 0.024 G1251T(K417N) C1256T(A419V) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) T1480C(S494P) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.008 G1251T(K417N) C1296T(C432C) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.023 0.022 0.004 G1251T(K417N) C1313T(S438F) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.004 G1251T(K417N) C1317T(N439N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.01 0.007 G1251T(K417N) G1258A(D420N) T1266C(N422N) T1320G(N440K) G1336A(G446S) G1340C(G447A) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.023 G1251T(K417N) T1253C(I418T) T1266C(N422N) T1320G(N440K) G1336A(G446S) G1340C(G447A) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.023 G1251T(K417N) T1266C(N422N) A1275T(L425F) T1320G(N440K) G1336A(G446S) G1340C(G447A) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.022 G1251T(K417N) T1266C(N422N) T1320G(N440K) G1336A(G446S) G1340C(G447A) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) A1585G(K529E) C1640A(T547K) 0.021 G1251T(K417N) T1266C(N422N) T1320G(N440K) G1336A(G446S) G1340C(G447A) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.135 G1251T(K417N) T1266C(N422N) T1320G(N440K) G1336A(G446S) G1340C(G447A) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) A1737G(P579P) 0.021 G1251T(K417N) T1266C(N422N) T1320G(N440K) G1336A(G446S) G1340C(G447A) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) C1678T(L560L) 0.023 G1251T(K417N) T1266C(N422N) T1320G(N440K) G1336A(G446S) G1340C(G447A) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) T1677C(F559F) 0.011 G1251T(K417N) T1266C(N422N) T1320G(N440K) G1336A(G446S) G1340C(G447A) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) T1677G(F559L) 0.013 G1251T(K417N) T1298C(V433A) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.001 G1251T(K417N) T1299C(V433V) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.005 0.014 G1251T(K417N) T1320G(N440K) A1325T(D442V) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1498T(T500S) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.017 G1251T(K417N) T1320G(N440K) A1325T(D442V) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.016 G1251T(K417N) T1320G(N440K) A1330C(K444Q) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) T1722A(D574E) 0.008 G1251T(K417N) T1320G(N440K) A1330G(K444E) GGT1336-1338AGC(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) T1722A(D574E) 0.014 G1251T(K417N) T1320G(N440K) G1336A(G446S) 0.004666666666666667 G1251T(K417N) T1320G(N440K) G1336A(G446S) 1384-insertA(462fs) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.003 G1251T(K417N) T1320G(N440K) G1336A(G446S) A1343T(N448I) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.02 G1251T(K417N) T1320G(N440K) G1336A(G446S) A1414C(I472L) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.007 G1251T(K417N) T1320G(N440K) G1336A(G446S) A1414G(I472V) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.017 G1251T(K417N) T1320G(N440K) G1336A(G446S) A1421G(Q474R) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.026 G1251T(K417N) T1320G(N440K) G1336A(G446S) C1433A(T478K) 0.002 0.035 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1339T(G447C) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.005 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1365A(L455L) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) C1738T(Q580*) 0.0033333333333333335 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) 0.002 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1459T(N487Y) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.003 0.004 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1460T(N487I) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.003 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1498T(T500S) A1501T(N501Y) T1513A(Y505N) C1640A(T547K) 0.018 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1498T(T500S) A1501T(N501Y) T1513C(Y505H) A1518C(Q506H) C1640A(T547K) 0.045 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1498T(T500S) A1501T(N501Y) T1513C(Y505H) C1516A(Q506K) C1640A(T547K) 0.34 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1498T(T500S) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.564 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) G1510T(G504C) T1513C(Y505H) C1640A(T547K) 0.002 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1512G(G504G) T1513C(Y505H) C1640A(T547K) 0.002 0.002 0.003 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513A(Y505N) C1516A(Q506K) C1640A(T547K) 0.008 0.012 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513A(Y505N) C1640A(T547K) 0.003 0.003 0.002 0.004 0.004 0.013 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) A1518C(Q506H) C1640A(T547K) 0.003 0.031 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1516A(Q506K) C1640A(T547K) 0.002 0.001 0.0033333333333333335 0.023 0.079 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1516A(Q506K) C1640A(T547K) C1715T(T572I) 0.025 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1519A(P507T) C1640A(T547K) 0.002 0.004 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1520A(P507Q) C1640A(T547K) 0.003 0.002 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1524A(Y508*) C1640A(T547K) 0.002 0.001 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1524T(Y508Y) C1640A(T547K) 0.003 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1559A(A520E) C1640A(T547K) 0.002 0.004 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1617T(V539V) T1635C(G545G) C1640A(T547K) T1663C(S555P) 0.004 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.664 0.795 0.726 0.78 0.847 0.13133333333333333 0.777 0.793 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 1708-insertG(570fs) 0.003 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) A1669-1669del(557fs) 0.006 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) A1669G(K557E) 0.005 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) A1672T(K558*) 0.021 0.02 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) A1692T(Q564H) 0.003 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) C1644T(G548G) 0.0036666666666666666 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) C1715T(T572I) 0.059 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) C1724T(A575V) 0.0026666666666666666 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) G1702A(D568N) C1753T(L585F) 0.021 0.021 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) T1650A(G550G) 0.023 0.022 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) T1656A(L552L) A1721G(D574G) 0.016 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) T1659C(T553T) 0.016 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) T1659G(T553T) 0.004 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) T1675C(F559L) 0.009 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) T1675G(F559V) 0.01 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) T1676A(F559Y) 0.0023333333333333335 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) T1676C(F559S) 0.013 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) T1676G(F559C) 0.013 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) T1710C(A570A) 0.006 0.003 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) T1710G(A570A) 0.018 0.014 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) CAA1516-1518AAC(Q506N) C1640A(T547K) 0.001 0.005 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) G1528T(V510L) C1640A(T547K) 0.001 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) G1564T(A522S) C1640A(T547K) 0.004 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) G1570A(V524I) C1640A(T547K) 0.003 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) G1599A(L533L) C1640A(T547K) 0.026 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) G1634A(G545D) C1640A(T547K) 0.019 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) T1522C(Y508H) C1640A(T547K) 0.003 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) T1522G(Y508D) C1640A(T547K) 0.003 0.002 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) T1529G(V510G) C1640A(T547K) 0.001 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) T1532G(V511G) C1640A(T547K) 0.001 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) T1535C(V512A) C1640A(T547K) 0.004 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) T1538G(L513R) C1640A(T547K) 0.001 0.003 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) T1539G(L513L) C1640A(T547K) 0.002 0.003 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) T1542C(S514S) C1640A(T547K) 0.005 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) T1542G(S514S) C1640A(T547K) 0.001 0.003 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) T1543G(F515V) C1640A(T547K) 0.003 0.003 0.006 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) T1544G(F515C) C1640A(T547K) 0.002 0.004 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) T1551G(L517L) C1640A(T547K) 0.001 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) T1622G(F541C) C1640A(T547K) 0.001 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) T1628C(F543S) C1640A(T547K) 0.003 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) TAC1513-1515CAA(Y505Q) C1640A(T547K) 0.003 0.002 0.007 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) C1491T(F497F) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.004 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) T1480C(S494P) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.431 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) C1640A(T547K) 0.006 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) T1455-1455del(485fs) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.004 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) T1455G(G485G) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.001 0.003 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) T1464-1464del(488fs) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.004 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) T1468-1468del(490fs) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.004 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) T1437C(P479P) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.004 G1251T(K417N) T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) T1438A(C480S) A1451C(E484A) T1462C(C488R) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.002 G1251T(K417N) T1320G(N440K) G1336A(G446S) T1359A(Y453*) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.011 0.012 G1251T(K417N) T1320G(N440K) G1336A(G446S) T1359C(Y453Y) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.006 G1251T(K417N) T1320G(N440K) G1336A(G446S) T1364C(L455S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.0029999999999999996 G1251T(K417N) T1320G(N440K) G1336A(G446S) T1389C(P463P) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.004 G1251T(K417N) T1320G(N440K) G1336A(G446S) T1428C(G476G) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.006 G1251T(K417N) T1320G(N440K) G1336C(G446R) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.002 G1251T(K417N) T1320G(N440K) G1430A(S477N) C1433A(T478K) A1451C(E484A) G1453-1453del(485fs) A1459T(N487Y) A1478G(Q493R) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) 0.008 G1251T(K417N) T1320G(N440K) G1430A(S477N) C1433A(T478K) A1451C(E484A) G1453-1453del(485fs) A1478G(Q493R) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) 0.397 G1251T(K417N) T1320G(N440K) GGT1336-1338AGC(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) A1518C(Q506H) C1640A(T547K) 0.014 G1251T(K417N) T1320G(N440K) GGT1336-1338AGC(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1580T(P527L) C1640A(T547K) 0.028 G1251T(K417N) T1320G(N440K) T1323C(L441L) GGT1336-1338AGC(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.026 G1251T(K417N) T1355G(L452R) C1433A(T478K) 0.259 G1251T(K417N) T1355G(L452R) C1433A(T478K) C1687A(Q563K) 0.003 G1251T(K417N) T1355G(L452R) G1422A(Q474Q) C1433A(T478K) 0.046 G1251T(K417N) T1355G(L452R) G1423T(A475S) C1433A(T478K) 0.007 G1307-1307del(436fs) G1430A(S477N) 0.051 G1307-1307del(436fs) G1430A(S477N) C1433T(T478I) 0.001 G1339A(G447S) T1355G(L452R) C1433A(T478K) 0.009333333333333334 G1339T(G447C) T1355G(L452R) C1433A(T478K) 0.001 0.129 G1339T(G447C) T1355G(L452R) G1411A(E471K) C1433A(T478K) 0.021 G1339T(G447C) T1355G(L452R) T1382C(L461P) C1433A(T478K) 0.002 G1411A(E471K) A1501T(N501Y) C1709A(A570D) C1718T(T573I) 0.047 G1423T(A475S) G1430A(S477N) 0.005 G1430A(S477N) 0.071 0.261 0.937 G1430A(S477N) A1501T(N501Y) 0.001 G1430A(S477N) A1525C(R509R) 0.002 G1430A(S477N) A1548C(E516D) 0.002 G1430A(S477N) A1609T(K537*) 0.007 G1430A(S477N) A1733C(D578A) 0.001 G1430A(S477N) C1433A(T478K) 0.003 G1430A(S477N) C1516A(Q506K) 0.002 G1430A(S477N) C1519A(P507T) 0.001 G1430A(S477N) C1520A(P507Q) 0.002 G1430A(S477N) C1524A(Y508*) 0.004 G1430A(S477N) C1559A(A520E) 0.003 G1430A(S477N) C1668A(N556K) 0.004 G1430A(S477N) C1709A(A570D) 0.004 G1430A(S477N) C1753-1753del(585fs) 0.001 G1430A(S477N) T1512G(G504G) 0.001 G1430A(S477N) T1722C(D574D) 0.002 G1430A(S477N) T1745-1745del(582fs) 0.001 G1430A(S477N) T1751-1751del(584fs) 0.001 G1430A(S477N) T1754-1754del(585fs) 0.002 G1450A(E484K) 0.297 0.2855 0.304 G1450A(E484K) C1644A(G548G) 0.0005 G1450A(E484K) C1709A(A570D) 0.006 G1450A(E484K) T1725C(A575A) 0.044 G1546T(E516*) 0.025 G710-710del(237fs) G1016A(G339D) G1037A(R346K) TCC1111-1113CTC(S371L) T1117C(S373P) C1124T(S375F) 0.001 G773A(W258*) G1016A(G339D) G1037A(R346K) TCC1111-1113CTC(S371L) T1117C(S373P) C1124T(S375F) 0.009666666666666667 GGG1237-1239AGT(G413S) T1355G(L452R) C1433A(T478K) 0.0013333333333333333 T1012G(F338V) G1016A(G339D) G1037A(R346K) TCC1111-1113CTC(S371L) T1117C(S373P) C1124T(S375F) 0.0013333333333333333 T1215-1215del(405fs) G1430A(S477N) 0.001 T1215-1215del(405fs) T1355G(L452R) C1433A(T478K) 0.002 0.001 0.001 0.001 0.001 0.0005 T1220-1220del(407fs) G1430A(S477N) 0.001 T1220-1220del(407fs) T1355G(L452R) C1433A(T478K) 0.001 T1274C(L425S) A1302G(I434M) C1317A(N439K) T1323C(L441L) G1332T(K444N) GTT1333-1335CGT(V445R) G1337A(G446D) TAT1345-1347CGT(Y449R) T1355A(L452Q) A1358T(Y453F) G1365T(L455F) T1368A(F456L) T1380G(N460K) T1401C(D467D) G1426A(G476S) G1430A(S477N) C1433G(T478R) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) GGT1510-1512GAG(G504E) T1513C(Y505H) C1516A(Q506K) T1557A(H519Q) C1682A(P561H) 0.011 T1287C(F429F) A1501T(N501Y) C1709A(A570D) 0.045 T1287C(F429F) A1501T(N501Y) C1709A(A570D) C1718T(T573I) 0.003 T1320G(N440K) G1336A(G446S) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.488 T1320G(N440K) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) 0.03766666666666667 T1355G(L452R) 0.091 0.1305 0.005 0.0015 T1355G(L452R) A1378C(N460H) C1433A(T478K) 0.001 T1355G(L452R) A1378G(N460D) C1433A(T478K) 0.003 T1355G(L452R) A1413C(E471D) C1433A(T478K) 0.004 T1355G(L452R) A1413G(E471E) C1433A(T478K) T1508C(V503A) 0.01 T1355G(L452R) A1414C(I472L) C1433A(T478K) 0.0005 T1355G(L452R) C1431T(S477S) C1433A(T478K) 0.541 0.255 0.4533333333333333 T1355G(L452R) C1431T(S477S) C1433A(T478K) A1525C(R509R) 0.002 T1355G(L452R) C1431T(S477S) C1433A(T478K) A1609T(K537*) 0.002 T1355G(L452R) C1431T(S477S) C1433A(T478K) C1520A(P507Q) 0.0006666666666666666 T1355G(L452R) C1431T(S477S) C1433A(T478K) C1524A(Y508*) 0.0016666666666666668 T1355G(L452R) C1431T(S477S) C1433A(T478K) C1559A(A520E) 0.0006666666666666666 T1355G(L452R) C1431T(S477S) C1433A(T478K) C1561A(P521T) 0.0006666666666666666 T1355G(L452R) C1431T(S477S) C1433A(T478K) G1642A(G548S) 0.003 T1355G(L452R) C1431T(S477S) C1433A(T478K) T1455G(G485G) 0.0016666666666666668 T1355G(L452R) C1431T(S477S) C1433A(T478K) T1512G(G504G) 0.004 0.0006666666666666666 T1355G(L452R) C1431T(S477S) C1433A(T478K) T1513G(Y505D) 0.002 0.0006666666666666666 T1355G(L452R) C1431T(S477S) C1433A(T478K) T1540G(S514A) 0.002 T1355G(L452R) C1431T(S477S) C1433A(T478K) T1543G(F515V) 0.0006666666666666666 T1355G(L452R) C1431T(S477S) C1433A(T478K) T1545G(F515L) 0.001 T1355G(L452R) C1431T(S477S) C1433A(T478K) T1627C(F543L) 0.014 T1355G(L452R) C1431T(S477S) C1433A(T478K) T1653A(V551V) 0.002 T1355G(L452R) C1431T(S477S) C1433A(T478K) T1693G(F565V) 0.0006666666666666666 T1355G(L452R) C1431T(S477S) C1433A(T478K) T1694G(F565C) 0.0006666666666666666 T1355G(L452R) C1431T(S477S) C1433A(T478K) T1722C(D574D) 0.001 T1355G(L452R) C1433A(T478K) 0.959 0.864 0.529 0.673 0.626 0.002 0.268 0.038 0.617 0.223 0.754 0.635 0.772 0.477 0.009 0.393 0.9804999999999999 0.355 0.03 0.321 0.021 T1355G(L452R) C1433A(T478K) A1451C(E484A) 0.009 T1355G(L452R) C1433A(T478K) A1451T(E484V) 0.005 T1355G(L452R) C1433A(T478K) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1498T(T500S) A1502C(N501T) G1511A(G504D) T1513C(Y505H) T1557A(H519Q) 0.001 T1355G(L452R) C1433A(T478K) A1451T(E484V) TTT1456-1458CCT(F486P) TTT1468-1470CCT(F490P) A1478G(Q493R) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) G1511A(G504D) T1513C(Y505H) T1557A(H519Q) 0.0005 T1355G(L452R) C1433A(T478K) A1459T(N487Y) 0.002 T1355G(L452R) C1433A(T478K) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.003 T1355G(L452R) C1433A(T478K) A1518C(Q506H) 0.005 T1355G(L452R) C1433A(T478K) A1518C(Q506H) T1722C(D574D) 0.007 T1355G(L452R) C1433A(T478K) A1525C(R509R) 0.001 0.002 0.0005 T1355G(L452R) C1433A(T478K) A1527C(R509S) 0.002 T1355G(L452R) C1433A(T478K) A1527G(R509R) 0.003 T1355G(L452R) C1433A(T478K) A1548C(E516D) 0.0015 T1355G(L452R) C1433A(T478K) A1560C(A520A) 0.001 0.001 T1355G(L452R) C1433A(T478K) A1692C(Q564H) 0.001 T1355G(L452R) C1433A(T478K) A1741C(T581P) 0.002 T1355G(L452R) C1433A(T478K) C1436A(P479H) 0.002 T1355G(L452R) C1433A(T478K) C1497A(P499P) 0.003 0.001 T1355G(L452R) C1433A(T478K) C1515A(Y505*) 0.001 0.001 T1355G(L452R) C1433A(T478K) C1515A(Y505*) T1722C(D574D) 0.003 T1355G(L452R) C1433A(T478K) C1516A(Q506K) 0.004 0.013 0.009 0.005 0.007 T1355G(L452R) C1433A(T478K) C1516A(Q506K) T1722C(D574D) 0.005 T1355G(L452R) C1433A(T478K) C1519A(P507T) 0.003 0.005 0.001 0.002 T1355G(L452R) C1433A(T478K) C1520A(P507Q) 0.001 0.003 0.001 0.006 0.001 0.001 T1355G(L452R) C1433A(T478K) C1524A(Y508*) 0.002 0.001 0.007 0.003 0.002 0.014 0.001 0.007 0.004 0.0026666666666666666 0.0055 T1355G(L452R) C1433A(T478K) C1524A(Y508*) C1715T(T572I) 0.004 T1355G(L452R) C1433A(T478K) C1537A(L513I) 0.001 0.001 0.002 0.0005 T1355G(L452R) C1433A(T478K) C1552A(L518I) 0.001 T1355G(L452R) C1433A(T478K) C1559A(A520E) 0.003 0.003 0.004 0.002 0.001 0.001 T1355G(L452R) C1433A(T478K) C1561A(P521T) 0.001 0.0015 T1355G(L452R) C1433A(T478K) C1565A(A522E) 0.002 0.001 T1355G(L452R) C1433A(T478K) C1580A(P527H) 0.001 T1355G(L452R) C1433A(T478K) C1626A(N542K) 0.001 T1355G(L452R) C1433A(T478K) C1629A(F543L) 0.001 T1355G(L452R) C1433A(T478K) C1640A(T547K) 0.001 T1355G(L452R) C1433A(T478K) C1644A(G548G) 0.002 T1355G(L452R) C1433A(T478K) C1644T(G548G) 0.003 T1355G(L452R) C1433A(T478K) C1687A(Q563K) C1715T(T572I) 0.005 T1355G(L452R) C1433A(T478K) C1715T(T572I) 0.395 T1355G(L452R) C1433A(T478K) G1439A(C480Y) A1451C(E484A) 0.004 T1355G(L452R) C1433A(T478K) G1439C(C480S) A1451C(E484A) 0.002 T1355G(L452R) C1433A(T478K) G1444T(G482C) 0.004 T1355G(L452R) C1433A(T478K) G1447T(V483F) 0.001 T1355G(L452R) C1433A(T478K) G1450C(E484Q) 0.0825 T1355G(L452R) C1433A(T478K) G1450T(E484*) 0.001 T1355G(L452R) C1433A(T478K) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1498T(T500S) A1502C(N501T) G1511A(G504D) T1513C(Y505H) T1557A(H519Q) 0.001 T1355G(L452R) C1433A(T478K) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1502C(N501T) G1511A(G504D) T1513C(Y505H) T1557A(H519Q) 0.006 T1355G(L452R) C1433A(T478K) G1507T(V503F) 0.002 T1355G(L452R) C1433A(T478K) G1528T(V510L) 0.001 T1355G(L452R) C1433A(T478K) G1534T(V512L) 0.0005 T1355G(L452R) C1433A(T478K) G1546T(E516*) 0.001 T1355G(L452R) C1433A(T478K) G1615C(V539L) 0.001 T1355G(L452R) C1433A(T478K) G1642A(G548S) 0.001 T1355G(L452R) C1433A(T478K) T1455A(G485G) 0.002 T1355G(L452R) C1433A(T478K) T1455C(G485G) 0.0016666666666666668 T1355G(L452R) C1433A(T478K) T1455G(G485G) 0.002 0.001 T1355G(L452R) C1433A(T478K) T1456G(F486V) 0.001 T1355G(L452R) C1433A(T478K) T1508C(V503A) 0.115 T1355G(L452R) C1433A(T478K) T1508C(V503A) G1720A(D574N) 0.025 T1355G(L452R) C1433A(T478K) T1512A(G504G) 0.0005 T1355G(L452R) C1433A(T478K) T1512G(G504G) 0.002 0.003 0.002 0.001 0.002 0.004 0.001 0.0015 0.001 T1355G(L452R) C1433A(T478K) T1512G(G504G) T1722C(D574D) 0.008 T1355G(L452R) C1433A(T478K) T1513G(Y505D) 0.001 0.002 0.001 0.0015 0.002 T1355G(L452R) C1433A(T478K) T1522G(Y508D) 0.001 0.001 0.0005 T1355G(L452R) C1433A(T478K) T1529G(V510G) 0.001 0.001 T1355G(L452R) C1433A(T478K) T1538G(L513R) 0.002 0.0005 T1355G(L452R) C1433A(T478K) T1539G(L513L) 0.002 0.002 0.003 0.004 0.001 T1355G(L452R) C1433A(T478K) T1540G(S514A) 0.002 0.001 0.002 0.001 T1355G(L452R) C1433A(T478K) T1542G(S514S) 0.003 0.003 0.004 T1355G(L452R) C1433A(T478K) T1543G(F515V) 0.002 0.012 0.011 0.001 0.001 T1355G(L452R) C1433A(T478K) T1544G(F515C) 0.005 0.004 T1355G(L452R) C1433A(T478K) T1545G(F515L) 0.001 0.001 T1355G(L452R) C1433A(T478K) T1550G(L517R) 0.004 0.001 T1355G(L452R) C1433A(T478K) T1551G(L517L) 0.002 T1355G(L452R) C1433A(T478K) T1551G(L517L) T1722C(D574D) 0.003 T1355G(L452R) C1433A(T478K) T1557G(H519Q) 0.001 0.003 0.0005 T1355G(L452R) C1433A(T478K) T1602C(V534V) 0.001 T1355G(L452R) C1433A(T478K) T1602G(V534V) 0.004 T1355G(L452R) C1433A(T478K) T1621A(F541I) 0.001 T1355G(L452R) C1433A(T478K) T1627C(F543L) C1715T(T572I) 0.012 T1355G(L452R) C1433A(T478K) T1627G(F543V) 0.013 0.001 T1355G(L452R) C1433A(T478K) T1627G(F543V) C1715T(T572I) 0.012 T1355G(L452R) C1433A(T478K) T1632C(N544N) 0.001 T1355G(L452R) C1433A(T478K) T1652A(V551D) 0.023 T1355G(L452R) C1433A(T478K) T1676G(F559C) 0.001 T1355G(L452R) C1433A(T478K) T1693G(F565V) 0.001 T1355G(L452R) C1433A(T478K) T1694G(F565C) 0.0005 0.001 T1355G(L452R) C1433A(T478K) T1722C(D574D) 0.002 0.005 0.2 0.001 0.249 0.35 0.0005 0.001 T1355G(L452R) C1433A(T478K) T1751-1751del(584fs) 0.001 0.001 0.001 0.0005 T1355G(L452R) C1433A(T478K) T1754-1754del(585fs) 0.001 0.002 0.001 0.001 0.001 0.0005 T1355G(L452R) C1433G(T478R) 0.002 T1355G(L452R) C1433T(T478I) 0.001 T1355G(L452R) G1374A(K458K) C1433A(T478K) C1640A(T547K) 0.003 T1355G(L452R) G1395T(E465D) C1433A(T478K) 0.002 T1355G(L452R) G1422A(Q474Q) C1433A(T478K) 0.003 T1355G(L452R) G1423T(A475S) C1433A(T478K) C1715T(T572I) 0.007 T1355G(L452R) G1430A(S477N) 0.002 T1355G(L452R) G1430A(S477N) C1433A(T478K) A1451C(E484A) A1478G(Q493R) G1486A(G496S) A1493G(Q498R) A1501T(N501Y) T1513C(Y505H) C1640A(T547K) 0.002 T1355G(L452R) GAAGTCTAATCTCAAACCTTTTGAGAGAGATATTT1371-1405del(457fs) C1433A(T478K) 0.002 T1355G(L452R) GGAAGTCTAATCTCAAACCTTTTGAGAGAGATATT1370-1404del(457fs) A1412T(E471V) C1433A(T478K) 0.002 T1355G(L452R) GGAAGTCTAATCTCAAACCTTTTGAGAGAGATATT1370-1404del(457fs) A1413C(E471D) C1433A(T478K) 0.003 T1355G(L452R) GGAAGTCTAATCTCAAACCTTTTGAGAGAGATATT1370-1404del(457fs) A1413G(E471E) C1433A(T478K) 0.002 T1355G(L452R) GGAAGTCTAATCTCAAACCTTTTGAGAGAGATATT1370-1404del(457fs) C1433A(T478K) 0.267 T1355G(L452R) GGAAGTCTAATCTCAAACCTTTTGAGAGAGATATT1370-1404del(457fs) C1433A(T478K) A1452T(E484D) 0.005 T1355G(L452R) GGAAGTCTAATCTCAAACCTTTTGAGAGAGATATT1370-1404del(457fs) C1433A(T478K) G1546T(E516*) 0.002 T1355G(L452R) GGAAGTCTAATCTCAAACCTTTTGAGAGAGATATT1370-1404del(457fs) C1433A(T478K) T1456G(F486V) 0.003 T1355G(L452R) T1363G(L455V) C1433A(T478K) 0.001 T1355G(L452R) T1382C(L461P) C1433A(T478K) 0.766 T1355G(L452R) T1382C(L461P) C1433A(T478K) A1514C(Y505S) 0.002 T1355G(L452R) T1382C(L461P) C1433A(T478K) A1521C(P507P) 0.002 T1355G(L452R) T1382C(L461P) C1433A(T478K) A1525C(R509R) 0.003 T1355G(L452R) T1382C(L461P) C1433A(T478K) A1527C(R509S) 0.004 T1355G(L452R) T1382C(L461P) C1433A(T478K) A1527G(R509R) 0.006 T1355G(L452R) T1382C(L461P) C1433A(T478K) A1527T(R509S) 0.002 T1355G(L452R) T1382C(L461P) C1433A(T478K) A1548C(E516D) 0.003 T1355G(L452R) T1382C(L461P) C1433A(T478K) C1497A(P499P) 0.004 T1355G(L452R) T1382C(L461P) C1433A(T478K) C1515A(Y505*) 0.002 T1355G(L452R) T1382C(L461P) C1433A(T478K) C1516A(Q506K) 0.013 T1355G(L452R) T1382C(L461P) C1433A(T478K) C1519A(P507T) 0.004 T1355G(L452R) T1382C(L461P) C1433A(T478K) C1520A(P507Q) 0.01 T1355G(L452R) T1382C(L461P) C1433A(T478K) C1524A(Y508*) 0.02 T1355G(L452R) T1382C(L461P) C1433A(T478K) C1537A(L513I) 0.004 T1355G(L452R) T1382C(L461P) C1433A(T478K) C1549A(L517I) 0.002 T1355G(L452R) T1382C(L461P) C1433A(T478K) C1559A(A520E) 0.008 T1355G(L452R) T1382C(L461P) C1433A(T478K) C1565A(A522E) 0.002 T1355G(L452R) T1382C(L461P) C1433A(T478K) G1463T(C488F) 0.004 T1355G(L452R) T1382C(L461P) C1433A(T478K) G1507T(V503F) 0.005 T1355G(L452R) T1382C(L461P) C1433A(T478K) G1511T(G504V) 0.003 T1355G(L452R) T1382C(L461P) C1433A(T478K) G1528T(V510L) 0.003 T1355G(L452R) T1382C(L461P) C1433A(T478K) G1531T(V511L) 0.002 T1355G(L452R) T1382C(L461P) C1433A(T478K) G1546T(E516*) 0.003 T1355G(L452R) T1382C(L461P) C1433A(T478K) T1512A(G504G) 0.002 T1355G(L452R) T1382C(L461P) C1433A(T478K) T1512G(G504G) 0.01 T1355G(L452R) T1382C(L461P) C1433A(T478K) T1513G(Y505D) 0.007 T1355G(L452R) T1382C(L461P) C1433A(T478K) T1522G(Y508D) 0.003 T1355G(L452R) T1382C(L461P) C1433A(T478K) T1529G(V510G) 0.003 T1355G(L452R) T1382C(L461P) C1433A(T478K) T1532G(V511G) 0.002 T1355G(L452R) T1382C(L461P) C1433A(T478K) T1538G(L513R) 0.002 T1355G(L452R) T1382C(L461P) C1433A(T478K) T1540G(S514A) 0.005 T1355G(L452R) T1382C(L461P) C1433A(T478K) T1543G(F515V) 0.003 T1355G(L452R) T1382C(L461P) C1433A(T478K) T1544G(F515C) 0.002 T1355G(L452R) T1382C(L461P) C1433A(T478K) T1545G(F515L) 0.006 T1355G(L452R) T1382C(L461P) C1433A(T478K) T1550G(L517R) 0.002 T1355G(L452R) T1382C(L461P) C1433A(T478K) T1557G(H519Q) 0.006 T1355G(L452R) T1382C(L461P) C1433A(T478K) T1693G(F565V) 0.002 T1355G(L452R) T1382C(L461P) C1433A(T478K) T1694G(F565C) 0.003 T1355G(L452R) T1382C(L461P) C1433A(T478K) T1754-1754del(585fs) 0.002 T1355G(L452R) T1382C(L461P) G1395T(E465D) C1433A(T478K) 0.003 T1355G(L452R) T1401C(D467D) G1430A(S477N) C1433A(T478K) A1451T(E484V) TTT1456-1458CCT(F486P) T1469C(F490S) G1487T(G496V) CAA1492-1494TAC(Q498Y) A1498T(T500S) A1502C(N501T) G1511A(G504D) T1513C(Y505H) T1557A(H519Q) 0.002 T1355G(L452R) T1404A(I468I) C1433A(T478K) C1715T(T572I) 0.003 T1355G(L452R) T1410A(T470T) C1433A(T478K) 0.0035 T1355G(L452R) T1410C(T470T) C1433A(T478K) 0.001 T1355G(L452R) T1410G(T470T) C1433A(T478K) 0.0015 T1512A(G504G) 0.03 T1512G(G504G) 0.075 T1513G(Y505D) 0.043 T1522G(Y508D) 0.026 T1538G(L513R) 0.025 T1539G(L513L) 0.026 T1540G(S514A) 0.032 T1543G(F515V) 0.023 T1545G(F515L) 0.033 T1557G(H519Q) 0.022 T1588A(S530T) 0.149 T1588G(S530A) 0.098 T712-712del(238fs) G1016A(G339D) G1037A(R346K) TCC1111-1113CTC(S371L) T1117C(S373P) C1124T(S375F) 0.0013333333333333333 T822C(T274T) G1016A(G339D) GTT1048-1050GNN(V350?) T1051N(Y351?) T1095N(Y365?) T1096N(S366?) TCC1111-1113CTC(S371L) T1117C(S373P) T1120N(F374?) C1124T(S375F) A1139N(Y380?) C1150N(P384?) G1213N(D405?) G1223A(R408K) 0.004666666666666667 T822C(T274T) G1016A(G339D) T1050N(V350?) T1095G(Y365*) TCC1111-1113CTC(S371L) T1117C(S373P) C1124T(S375F) A1139N(Y380?) C1150N(P384?) G1213N(D405?) 0.002 T822C(T274T) G1016A(G339D) TCC1111-1113CTC(S371L) T1117C(S373P) C1124T(S375F) 0.26 T822C(T274T) G1016A(G339D) TCC1111-1113CTC(S371L) T1117C(S373P) C1124T(S375F) A1139N(Y380?) 0.001 T822C(T274T) G1016A(G339D) TCC1111-1113CTC(S371L) T1117C(S373P) C1124T(S375F) A1139N(Y380?) A1187N(Y396?) 0.008666666666666666 T822C(T274T) G1016A(G339D) TCC1111-1113CTC(S371L) T1117C(S373P) C1124T(S375F) A1139N(Y380?) G1213N(D405?) 0.023999999999999997 T822C(T274T) G1016A(G339D) TCC1111-1113CTC(S371L) T1117C(S373P) C1124T(S375F) A1242G(Q414Q) 0.011999999999999999 T822C(T274T) G1016A(G339D) TCC1111-1113CTC(S371L) T1117C(S373P) C1124T(S375F) C1244A(T415N) 0.0026666666666666666 T822C(T274T) G1016A(G339D) TCC1111-1113CTC(S371L) T1117C(S373P) C1124T(S375F) G1192A(D398N) 0.004 T822C(T274T) G1016A(G339D) TCC1111-1113CTC(S371L) T1117C(S373P) C1124T(S375F) T1129G(F377V) T1159G(L387V) C1244A(T415N) 0.0013333333333333333 T822C(T274T) G1016A(G339D) TCC1111-1113CTC(S371L) T1117C(S373P) C1124T(S375F) T1137G(C379W) A1139N(Y380?) G1213N(D405?) 0.005999999999999999 T822C(T274T) T1012G(F338V) G1016A(G339D) TCC1111-1113CTC(S371L) T1117C(S373P) C1124T(S375F) 0.0013333333333333333 T823C(F275L) G1016A(G339D) G1037A(R346K) TCC1111-1113CTC(S371L) T1117C(S373P) C1124T(S375F) 0.009