KEGG_A_class	KEGG_B_class	Pathway	Cyc_30-vs-Cyc_0 (288)	All (6729)	Pvalue	Qvalue	Pathway ID	Genes	K_IDs
Metabolism	Lipid metabolism	Steroid biosynthesis	11	19	4.074455e-11	1.226411e-08	ko00100	ENSGALG00000006198(LSS);ENSGALG00000048205(-);ENSGALG00000004106(DHCR7);ENSGALG00000009560(MSMO1);ENSGALG00000036915(SQLE);ENSGALG00000010798(DHCR24);ENSGALG00000016665(FDFT1);ENSGALG00000037065(SC5D);ENSGALG00000007493(NSDHL);ENSGALG00000009365(CYP51A1);MSTRG.6502(CYP24A1)	K01852+K01824+K00213+K07750+K00511+K09828+K00801+K00227+K07748+K05917+K07436
Metabolism	Metabolism of terpenoids and polyketides	Terpenoid backbone biosynthesis	8	21	1.278549e-06	1.924216e-04	ko00900	ENSGALG00000011659(ACAT2);ENSGALG00000014948(HMGCR);ENSGALG00000007267(MVD);ENSGALG00000046656(PMVK);ENSGALG00000028880(FDPS);ENSGALG00000013848(MVK);ENSGALG00000006723(-);ENSGALG00000014862(HMGCS1)	K00626+K00021+K01597+K13273+K00787+K00869+K01823+K01641
Metabolism	Global and overview maps	Metabolic pathways	86	1406	0.0001533995	1.539108e-02	ko01100	ENSGALG00000006134(HOGA1);ENSGALG00000030781(CA2);ENSGALG00000026757(DHFR);ENSGALG00000001749(ACSBG2);ENSGALG00000006482(FAH);ENSGALG00000007936(PGK2);ENSGALG00000011659(ACAT2);ENSGALG00000054784(-);ENSGALG00000047947(-);ENSGALG00000016442(RRM2);ENSGALG00000033365(ALDH1A3);ENSGALG00000008930(B3GNT2);ENSGALG00000054319(ELOVL6);ENSGALG00000031652(AK5);ENSGALG00000012834(AKR1D1);ENSGALG00000016456(LPIN1);ENSGALG00000002899(AACS);ENSGALG00000006198(LSS);ENSGALG00000027874(CHAC1);ENSGALG00000014948(HMGCR);ENSGALG00000048205(-);ENSGALG00000012890(DGKI);ENSGALG00000003475(ACLY);ENSGALG00000035946(GUCY1A1);ENSGALG00000053647(-);ENSGALG00000004106(DHCR7);ENSGALG00000007267(MVD);ENSGALG00000009560(MSMO1);ENSGALG00000030344(ISYNA1);ENSGALG00000009538(-);ENSGALG00000054059(-);ENSGALG00000017350(RRM1);ENSGALG00000052712(-);ENSGALG00000036915(SQLE);ENSGALG00000046656(PMVK);ENSGALG00000031013(DHDH);ENSGALG00000010798(DHCR24);ENSGALG00000042374(-);ENSGALG00000034655(ALDH18A1);ENSGALG00000016665(FDFT1);ENSGALG00000028880(FDPS);ENSGALG00000013848(MVK);ENSGALG00000006300(LDHA);ENSGALG00000037065(SC5D);ENSGALG00000039575(AMD1);ENSGALG00000010402(HPGDS);ENSGALG00000001130(GALNT17);ENSGALG00000015180(PSAT1);ENSGALG00000034741(ETNPPL);ENSGALG00000011414(AMDHD1);ENSGALG00000043734(LIPG);ENSGALG00000014897(TYMS);ENSGALG00000016047(HLCS);ENSGALG00000006344(GSTT1);ENSGALG00000040504(GGT5);ENSGALG00000005046(SHMT1);ENSGALG00000039742(CYP21A1);ENSGALG00000003063(HYKK);ENSGALG00000007127(FADS1);ENSGALG00000007178(FADS2);ENSGALG00000006723(-);ENSGALG00000006939(PFKP);ENSGALG00000012692(SIRT5);ENSGALG00000003456(CA12);ENSGALG00000033635(PTGS2);ENSGALG00000030376(DHRS3);ENSGALG00000021340(CA9);ENSGALG00000012312(GCAT);ENSGALG00000007493(NSDHL);ENSGALG00000003432(AGXT2);ENSGALG00000004531(PLOD1);ENSGALG00000025772(ELOVL3);ENSGALG00000014862(HMGCS1);ENSGALG00000033338(GPT2);ENSGALG00000005857(ALOX5);ENSGALG00000016314(ELOVL5);ENSGALG00000009365(CYP51A1);ENSGALG00000004270(ALDH1A2);ENSGALG00000012377(HNMT);ENSGALG00000016724(RGN);ENSGALG00000007508(HPSE2);ENSGALG00000023435(GATM);MSTRG.11063(B4GALNT4);MSTRG.1212(--);MSTRG.12900(PHGDH);MSTRG.6502(CYP24A1)	K18123+K18245+K00287+K15013+K01555+K00927+K00626+K00710+K00789+K10808+K00129+K00741+K10203+K00939+K00251+K15728+K01907+K01852+K07232+K00021+K01824+K00901+K01648+K12318+K01952+K00213+K01597+K07750+K01858+K11153+K01513+K10807+K00789+K00511+K13273+K00078+K09828+K13298+K12657+K00801+K00787+K00869+K00016+K00227+K01611+K04097+K00710+K00831+K14286+K01468+K22284+K00560+K01942+K00799+K18592+K00600+K00513+K18201+K10224+K10226+K01823+K00850+K11415+K01672+K11987+K11146+K01672+K00639+K07748+K00827+K00473+K10203+K01641+K00814+K00461+K10244+K05917+K07249+K00546+K01053+K07965+K00613+K09656+K16855+K00058+K07436
Genetic Information Processing	Replication and repair	DNA replication	7	33	0.000400063	3.010474e-02	ko03030	ENSGALG00000029292(PCNA);ENSGALG00000029449(RFC2);ENSGALG00000004037(DNA2);ENSGALG00000012915(MCM4);ENSGALG00000007665(POLE);ENSGALG00000012546(MCM5);ENSGALG00000012348(MCM6)	K04802+K10755+K10742+K02212+K02324+K02209+K02542
Metabolism	Global and overview maps	Biosynthesis of amino acids	9	65	0.00164804	9.767097e-02	ko01230	ENSGALG00000007936(PGK2);ENSGALG00000047947(-);ENSGALG00000052712(-);ENSGALG00000034655(ALDH18A1);ENSGALG00000015180(PSAT1);ENSGALG00000005046(SHMT1);ENSGALG00000006939(PFKP);ENSGALG00000033338(GPT2);MSTRG.12900(PHGDH)	K00927+K00789+K00789+K12657+K00831+K00600+K00850+K00814+K00058
Human Diseases	Infectious diseases	Malaria	8	55	0.00215394	9.767097e-02	ko05144	ENSGALG00000010915(IL6);ENSGALG00000014804(THBS4);ENSGALG00000003283(-);ENSGALG00000009626(THBS1);ENSGALG00000031430(-);ENSGALG00000033974(HGF);ENSGALG00000005257(-);ENSGALG00000046160(-)	K05405+K04659+K04659+K16857+K06494+K05460+K06527+K10030
Cellular Processes	Cell growth and death	p53 signaling pathway	9	68	0.002271418	9.767097e-02	ko04115	ENSGALG00000017204(SESN3);ENSGALG00000040794(CCNE2);ENSGALG00000016442(RRM2);ENSGALG00000008346(CASP18);ENSGALG00000028318(CDKN1A);ENSGALG00000009626(THBS1);ENSGALG00000003085(CDK1);ENSGALG00000001718(CCNG1);ENSGALG00000037603(SESN2)	K10141+K06626+K10808+K04398+K06625+K16857+K02087+K10145+K20394
Metabolism	Amino acid metabolism	Cysteine and methionine metabolism	7	46	0.00311454	1.171846e-01	ko00270	ENSGALG00000047947(-);ENSGALG00000052712(-);ENSGALG00000006300(LDHA);ENSGALG00000039575(AMD1);ENSGALG00000015180(PSAT1);ENSGALG00000003432(AGXT2);MSTRG.12900(PHGDH)	K00789+K00789+K00016+K01611+K00831+K00827+K00058
Environmental Information Processing	Membrane transport	ABC transporters	7	47	0.003528652	1.180138e-01	ko02010	ENSGALG00000003553(ABCA12);ENSGALG00000006795(ABCG4);ENSGALG00000021395(-);ENSGALG00000016164(ABCG1);ENSGALG00000005752(ABCA4);ENSGALG00000015433(ABCA1);ENSGALG00000053916(ABCB1)	K05646+K05680+K05651+K05679+K05644+K05641+K05658
Human Diseases	Drug resistance	Antifolate resistance	5	27	0.005153884	1.551319e-01	ko01523	ENSGALG00000026757(DHFR);ENSGALG00000010915(IL6);ENSGALG00000010293(RBP);ENSGALG00000014897(TYMS);ENSGALG00000005046(SHMT1)	K00287+K05405+K13649+K00560+K00600
Metabolism	Amino acid metabolism	Glycine, serine and threonine metabolism	6	41	0.007413866	2.028703e-01	ko00260	ENSGALG00000015180(PSAT1);ENSGALG00000005046(SHMT1);ENSGALG00000012312(GCAT);ENSGALG00000003432(AGXT2);ENSGALG00000023435(GATM);MSTRG.12900(PHGDH)	K00831+K00600+K00639+K00827+K00613+K00058
Human Diseases	Cardiovascular diseases	Fluid shear stress and atherosclerosis	12	128	0.008428567	2.114166e-01	ko05418	ENSGALG00000035804(SQSTM1);ENSGALG00000014786(PIK3R1);ENSGALG00000031430(-);ENSGALG00000040360(DUSP1);ENSGALG00000006344(GSTT1);ENSGALG00000004370(MAP2K6);ENSGALG00000006707(NOX1);ENSGALG00000000379(ITGB3);ENSGALG00000005257(-);ENSGALG00000003580(MMP2);MSTRG.8303(THBD);MSTRG.9359(--)	K14381+K02649+K06494+K21278+K00799+K04433+K08008+K06493+K06527+K01398+K03907+K10456
Metabolism	Global and overview maps	Fatty acid metabolism	7	58	0.01131885	2.527826e-01	ko01212	ENSGALG00000001749(ACSBG2);ENSGALG00000011659(ACAT2);ENSGALG00000054319(ELOVL6);ENSGALG00000007127(FADS1);ENSGALG00000007178(FADS2);ENSGALG00000025772(ELOVL3);ENSGALG00000016314(ELOVL5)	K15013+K00626+K10203+K10224+K10226+K10203+K10244
Human Diseases	Cancers	MicroRNAs in cancer	13	150	0.01175733	2.527826e-01	ko05206	ENSGALG00000014786(PIK3R1);ENSGALG00000040794(CCNE2);ENSGALG00000040079(ZFPM2);ENSGALG00000002781(BRCA1);ENSGALG00000028318(CDKN1A);ENSGALG00000009626(THBS1);ENSGALG00000013929(PDGFRA);ENSGALG00000001718(CCNG1);ENSGALG00000041459(DDIT4);ENSGALG00000033635(PTGS2);ENSGALG00000000379(ITGB3);ENSGALG00000053916(ABCB1);MSTRG.6502(CYP24A1)	K02649+K06626+K17442+K10605+K06625+K16857+K04363+K10145+K08270+K11987+K06493+K05658+K07436
Metabolism	Metabolism of other amino acids	Glutathione metabolism	6	46	0.0129284	2.594299e-01	ko00480	ENSGALG00000016442(RRM2);ENSGALG00000027874(CHAC1);ENSGALG00000017350(RRM1);ENSGALG00000010402(HPGDS);ENSGALG00000006344(GSTT1);ENSGALG00000040504(GGT5)	K10808+K07232+K10807+K04097+K00799+K18592
Metabolism	Lipid metabolism	Biosynthesis of unsaturated fatty acids	5	34	0.0139254	2.619716e-01	ko01040	ENSGALG00000054319(ELOVL6);ENSGALG00000007127(FADS1);ENSGALG00000007178(FADS2);ENSGALG00000025772(ELOVL3);ENSGALG00000016314(ELOVL5)	K10203+K10224+K10226+K10203+K10244
Genetic Information Processing	Replication and repair	Fanconi anemia pathway	6	51	0.02082534	3.658382e-01	ko03460	ENSGALG00000034534(FAAP24);ENSGALG00000000102(UBE2T);ENSGALG00000003660(FANCF);ENSGALG00000002781(BRCA1);ENSGALG00000002561(-);ENSGALG00000030022(FANCL)	K10898+K13960+K10893+K10605+K10892+K10606
Human Diseases	Cancers	Bladder cancer	5	38	0.02187737	3.658382e-01	ko05219	ENSGALG00000019061(MMP1);ENSGALG00000028318(CDKN1A);ENSGALG00000009626(THBS1);ENSGALG00000003580(MMP2);ENSGALG00000046160(-)	K01388+K06625+K16857+K01398+K10030
Human Diseases	Endocrine and metabolic diseases	AGE-RAGE signaling pathway in diabetic complications	9	100	0.02682267	4.080196e-01	ko04933	ENSGALG00000014786(PIK3R1);ENSGALG00000010915(IL6);ENSGALG00000031430(-);ENSGALG00000006707(NOX1);ENSGALG00000005257(-);ENSGALG00000003580(MMP2);ENSGALG00000046160(-);ENSGALG00000035584(COL3A1);MSTRG.8303(THBD)	K02649+K05405+K06494+K08008+K06527+K01398+K10030+K19720+K03907
Cellular Processes	Cellular community - eukaryotes	Focal adhesion	15	203	0.02711094	4.080196e-01	ko04510	ENSGALG00000014786(PIK3R1);ENSGALG00000014804(THBS4);ENSGALG00000005974(COL6A1);ENSGALG00000050728(-);ENSGALG00000003283(-);ENSGALG00000042458(ACTN1);ENSGALG00000030712(COL2A1);ENSGALG00000009626(THBS1);ENSGALG00000013929(PDGFRA);ENSGALG00000047771(PGF);ENSGALG00000001793(MYL10);ENSGALG00000000379(ITGB3);ENSGALG00000033974(HGF);ENSGALG00000008193(RELN);ENSGALG00000011708(MYLK)	K02649+K04659+K06238+K06586+K04659+K05699+K19719+K16857+K04363+K16859+K12756+K06493+K05460+K06249+K00907
Cellular Processes	Cell growth and death	Cell cycle	10	119	0.03077494	4.411075e-01	ko04110	ENSGALG00000040794(CCNE2);ENSGALG00000029292(PCNA);ENSGALG00000026137(CDKN2B);ENSGALG00000028318(CDKN1A);ENSGALG00000010623(ORC1);ENSGALG00000003085(CDK1);ENSGALG00000012915(MCM4);ENSGALG00000012546(MCM5);ENSGALG00000012348(MCM6);MSTRG.11197(Cdkn1c)	K06626+K04802+K04685+K06625+K02603+K02087+K02212+K02209+K02542+K09993
Metabolism	Lipid metabolism	Fatty acid elongation	4	29	0.03358125	4.423254e-01	ko00062	ENSGALG00000054319(ELOVL6);ENSGALG00000026039(THEM4);ENSGALG00000025772(ELOVL3);ENSGALG00000016314(ELOVL5)	K10203+K16339+K10203+K10244
Metabolism	Energy metabolism	Nitrogen metabolism	3	17	0.03379895	4.423254e-01	ko00910	ENSGALG00000030781(CA2);ENSGALG00000003456(CA12);ENSGALG00000021340(CA9)	K18245+K01672+K01672
Environmental Information Processing	Signaling molecules and interaction	ECM-receptor interaction	8	93	0.04494042	5.282156e-01	ko04512	ENSGALG00000014804(THBS4);ENSGALG00000005974(COL6A1);ENSGALG00000050728(-);ENSGALG00000003283(-);ENSGALG00000030712(COL2A1);ENSGALG00000009626(THBS1);ENSGALG00000000379(ITGB3);ENSGALG00000008193(RELN)	K04659+K06238+K06586+K04659+K19719+K16857+K06493+K06249
Metabolism	Metabolism of cofactors and vitamins	One carbon pool by folate	3	19	0.04524488	5.282156e-01	ko00670	ENSGALG00000026757(DHFR);ENSGALG00000014897(TYMS);ENSGALG00000005046(SHMT1)	K00287+K00560+K00600
Genetic Information Processing	Replication and repair	Base excision repair	4	32	0.04604845	5.282156e-01	ko03410	ENSGALG00000029292(PCNA);ENSGALG00000017493(-);ENSGALG00000001586(NEIL1);ENSGALG00000007665(POLE)	K04802+K10803+K10567+K02324
Environmental Information Processing	Signal transduction	TNF signaling pathway	8	94	0.04738147	5.282156e-01	ko04668	ENSGALG00000014786(PIK3R1);ENSGALG00000010915(IL6);ENSGALG00000009020(JAG1);ENSGALG00000008346(CASP18);ENSGALG00000031430(-);ENSGALG00000004370(MAP2K6);ENSGALG00000033635(PTGS2);ENSGALG00000005257(-)	K02649+K05405+K06052+K04398+K06494+K04433+K11987+K06527
Genetic Information Processing	Replication and repair	Mismatch repair	3	20	0.05159714	5.546693e-01	ko03430	ENSGALG00000029292(PCNA);ENSGALG00000029449(RFC2);ENSGALG00000010748(EXO1)	K04802+K10755+K10746
Metabolism	Lipid metabolism	Synthesis and degradation of ketone bodies	2	10	0.06546698	6.795021e-01	ko00072	ENSGALG00000011659(ACAT2);ENSGALG00000014862(HMGCS1)	K00626+K01641
Metabolism	Amino acid metabolism	Histidine metabolism	3	23	0.07304087	6.890389e-01	ko00340	ENSGALG00000033365(ALDH1A3);ENSGALG00000011414(AMDHD1);ENSGALG00000012377(HNMT)	K00129+K01468+K00546