KEGG_A_class	KEGG_B_class	Pathway	profile19 (70)	All (6729)	Pvalue	Qvalue	Pathway ID	Genes	K_IDs
Environmental Information Processing	Membrane transport	ABC transporters	5	47	0.0001152339	0.02131827	ko02010	ENSGALG00000003553(ABCA12);ENSGALG00000016164(ABCG1);ENSGALG00000005752(ABCA4);ENSGALG00000015433(ABCA1);ENSGALG00000053916(ABCB1)	K05646+K05679+K05644+K05641+K05658
Cellular Processes	Cell growth and death	p53 signaling pathway	4	68	0.005301451	0.49038422	ko04115	ENSGALG00000008346(CASP18);ENSGALG00000028318(CDKN1A);ENSGALG00000009626(THBS1);ENSGALG00000001718(CCNG1)	K04398+K06625+K16857+K10145
Human Diseases	Cardiovascular diseases	Fluid shear stress and atherosclerosis	5	128	0.01039383	0.53738153	ko05418	ENSGALG00000035804(SQSTM1);ENSGALG00000040360(DUSP1);ENSGALG00000006344(GSTT1);ENSGALG00000006707(NOX1);MSTRG.9359(--)	K14381+K21278+K00799+K08008+K10456
Metabolism	Amino acid metabolism	Cysteine and methionine metabolism	3	46	0.01189059	0.53738153	ko00270	ENSGALG00000047947(-);ENSGALG00000052712(-);ENSGALG00000003432(AGXT2)	K00789+K00789+K00827
Environmental Information Processing	Signal transduction	TGF-beta signaling pathway	4	94	0.01623298	0.53738153	ko04350	ENSGALG00000009626(THBS1);ENSGALG00000009724(GREM1);ENSGALG00000035317(ID3);ENSGALG00000014908(FST)	K16857+K23318+K17694+K04661
Environmental Information Processing	Signal transduction	Notch signaling pathway	3	53	0.01742859	0.53738153	ko04330	ENSGALG00000009020(JAG1);ENSGALG00000034716(HEY2);ENSGALG00000035031(HEY1)	K06052+K09091+K09091
Metabolism	Glycan biosynthesis and metabolism	Glycosphingolipid biosynthesis - lacto and neolacto series	2	25	0.02743134	0.63492856	ko00601	ENSGALG00000008930(B3GNT2);ENSGALG00000048035(GCNT2)	K00741+K00742
Human Diseases	Drug resistance	Platinum drug resistance	3	63	0.02745637	0.63492856	ko01524	ENSGALG00000008346(CASP18);ENSGALG00000028318(CDKN1A);ENSGALG00000006344(GSTT1)	K04398+K06625+K00799
Human Diseases	Drug resistance	Antifolate resistance	2	27	0.03167118	0.65101870	ko01523	ENSGALG00000010915(IL6);ENSGALG00000010293(RBP)	K05405+K13649
Organismal Systems	Endocrine system	Insulin secretion	3	74	0.04136407	0.76523530	ko04911	ENSGALG00000040256(RIMS2);ENSGALG00000020505(KCNJ11);ENSGALG00000011104(GCG)	K15297+K05004+K05259
Human Diseases	Cancers	Breast cancer	4	137	0.05377153	0.78214194	ko05224	ENSGALG00000009020(JAG1);ENSGALG00000028318(CDKN1A);ENSGALG00000034716(HEY2);ENSGALG00000035031(HEY1)	K06052+K06625+K09091+K09091
Human Diseases	Cancers	Bladder cancer	2	38	0.05898589	0.78214194	ko05219	ENSGALG00000028318(CDKN1A);ENSGALG00000009626(THBS1)	K06625+K16857
Human Diseases	Cardiovascular diseases	Hypertrophic cardiomyopathy (HCM)	3	89	0.06499921	0.78214194	ko05410	ENSGALG00000010915(IL6);ENSGALG00000052741(-);ENSGALG00000052907(-)	K05405+K12567+K12567
Metabolism	Amino acid metabolism	Glycine, serine and threonine metabolism	2	41	0.06746009	0.78214194	ko00260	ENSGALG00000003432(AGXT2);ENSGALG00000023435(GATM)	K00827+K00613
Human Diseases	Substance dependence	Cocaine addiction	2	41	0.06746009	0.78214194	ko05030	ENSGALG00000027415(GRIN2C);ENSGALG00000012163(BDNF)	K05211+K04355
Human Diseases	Cancers	MicroRNAs in cancer	4	150	0.07027944	0.78214194	ko05206	ENSGALG00000028318(CDKN1A);ENSGALG00000009626(THBS1);ENSGALG00000001718(CCNG1);ENSGALG00000053916(ABCB1)	K06625+K16857+K10145+K05658
Environmental Information Processing	Signal transduction	TNF signaling pathway	3	94	0.07400356	0.78214194	ko04668	ENSGALG00000010915(IL6);ENSGALG00000009020(JAG1);ENSGALG00000008346(CASP18)	K05405+K06052+K04398
Organismal Systems	Immune system	Toll-like receptor signaling pathway	3	99	0.08353423	0.78214194	ko04620	ENSGALG00000010915(IL6);ENSGALG00000008346(CASP18);ENSGALG00000016590(TLR7)	K05405+K04398+K05404
Metabolism	Metabolism of cofactors and vitamins	Riboflavin metabolism	1	9	0.08987313	0.78214194	ko00740	ENSGALG00000054059(-)	K01513
Human Diseases	Infectious diseases	Legionellosis	2	55	0.111505	0.78214194	ko05134	ENSGALG00000010915(IL6);ENSGALG00000008346(CASP18)	K05405+K04398
Human Diseases	Infectious diseases	Malaria	2	55	0.111505	0.78214194	ko05144	ENSGALG00000010915(IL6);ENSGALG00000009626(THBS1)	K05405+K16857
Metabolism	Carbohydrate metabolism	Ascorbate and aldarate metabolism	1	12	0.1180235	0.78214194	ko00053	ENSGALG00000016724(RGN)	K01053
Cellular Processes	Transport and catabolism	Mitophagy - animal	2	59	0.1251904	0.78214194	ko04137	ENSGALG00000035804(SQSTM1);ENSGALG00000002403(ULK1)	K14381+K21357
Human Diseases	Infectious diseases	Human papillomavirus infection	6	335	0.1341744	0.78214194	ko05165	ENSGALG00000009020(JAG1);ENSGALG00000008346(CASP18);ENSGALG00000028318(CDKN1A);ENSGALG00000009626(THBS1);ENSGALG00000034716(HEY2);ENSGALG00000035031(HEY1)	K06052+K04398+K06625+K16857+K09091+K09091
Human Diseases	Infectious diseases	Measles	3	125	0.1405689	0.78214194	ko05162	ENSGALG00000010915(IL6);ENSGALG00000008346(CASP18);ENSGALG00000016590(TLR7)	K05405+K04398+K05404
Environmental Information Processing	Signal transduction	FoxO signaling pathway	3	126	0.1429809	0.78214194	ko04068	ENSGALG00000010915(IL6);ENSGALG00000028318(CDKN1A);ENSGALG00000041202(FBXO32)	K05405+K06625+K10305
Metabolism	Global and overview maps	Biosynthesis of amino acids	2	65	0.1464154	0.78214194	ko01230	ENSGALG00000047947(-);ENSGALG00000052712(-)	K00789+K00789
Organismal Systems	Endocrine system	Renin secretion	2	65	0.1464154	0.78214194	ko04924	ENSGALG00000050155(CLCA2);ENSGALG00000035946(GUCY1A1)	K05028+K12318
Human Diseases	Cancers	Pathways in cancer	8	502	0.1485169	0.78214194	ko05200	ENSGALG00000010915(IL6);ENSGALG00000009020(JAG1);ENSGALG00000008346(CASP18);ENSGALG00000028318(CDKN1A);ENSGALG00000034716(HEY2);ENSGALG00000006344(GSTT1);ENSGALG00000035031(HEY1);MSTRG.9359(--)	K05405+K06052+K04398+K06625+K09091+K00799+K09091+K10456
Metabolism	Glycan biosynthesis and metabolism	Glycosaminoglycan biosynthesis - keratan sulfate	1	16	0.1542262	0.78214194	ko00533	ENSGALG00000008930(B3GNT2)	K00741
Human Diseases	Infectious diseases	Hepatitis C	3	137	0.1703883	0.78214194	ko05160	ENSGALG00000001621(CLDN5);ENSGALG00000008346(CASP18);ENSGALG00000028318(CDKN1A)	K06087+K04398+K06625
Metabolism	Metabolism of cofactors and vitamins	Pantothenate and CoA biosynthesis	1	18	0.1717742	0.78214194	ko00770	ENSGALG00000054059(-)	K01513
Human Diseases	Neurodegenerative diseases	Alzheimer disease	5	293	0.1882807	0.78214194	ko05010	ENSGALG00000027415(GRIN2C);ENSGALG00000002403(ULK1);ENSGALG00000010915(IL6);ENSGALG00000008346(CASP18);ENSGALG00000006707(NOX1)	K05211+K21357+K05405+K04398+K08008
Human Diseases	Drug resistance	EGFR tyrosine kinase inhibitor resistance	2	78	0.1945299	0.78214194	ko01521	ENSGALG00000010915(IL6);ENSGALG00000015422(NRG1)	K05405+K05455
Organismal Systems	Immune system	IL-17 signaling pathway	2	79	0.1983187	0.78214194	ko04657	ENSGALG00000010915(IL6);ENSGALG00000008346(CASP18)	K05405+K04398
Human Diseases	Neurodegenerative diseases	Prion diseases	1	22	0.2058004	0.78214194	ko05020	ENSGALG00000010915(IL6)	K05405
Environmental Information Processing	Signal transduction	ErbB signaling pathway	2	82	0.2097389	0.78214194	ko04012	ENSGALG00000028318(CDKN1A);ENSGALG00000015422(NRG1)	K06625+K05455
Organismal Systems	Endocrine system	Oxytocin signaling pathway	3	152	0.2099452	0.78214194	ko04921	ENSGALG00000035946(GUCY1A1);ENSGALG00000028318(CDKN1A);ENSGALG00000004721(-)	K12318+K06625+K05005
Human Diseases	Infectious diseases	Hepatitis B	3	153	0.2126557	0.78214194	ko05161	ENSGALG00000010915(IL6);ENSGALG00000008346(CASP18);ENSGALG00000028318(CDKN1A)	K05405+K04398+K06625
Human Diseases	Drug resistance	Endocrine resistance	2	83	0.2135615	0.78214194	ko01522	ENSGALG00000009020(JAG1);ENSGALG00000028318(CDKN1A)	K06052+K06625
Metabolism	Amino acid metabolism	Histidine metabolism	1	23	0.2140894	0.78214194	ko00340	ENSGALG00000011414(AMDHD1)	K01468
Human Diseases	Infectious diseases	Influenza A	3	154	0.215374	0.78214194	ko05164	ENSGALG00000010915(IL6);ENSGALG00000008346(CASP18);ENSGALG00000016590(TLR7)	K05405+K04398+K05404
Cellular Processes	Cell growth and death	Cellular senescence	3	155	0.2181001	0.78214194	ko04218	ENSGALG00000035804(SQSTM1);ENSGALG00000010915(IL6);ENSGALG00000028318(CDKN1A)	K14381+K05405+K06625
Human Diseases	Cancers	Hepatocellular carcinoma	3	158	0.2263224	0.78214194	ko05225	ENSGALG00000028318(CDKN1A);ENSGALG00000006344(GSTT1);MSTRG.9359(--)	K06625+K00799+K10456
Organismal Systems	Development and regeneration	Axon regeneration	2	89	0.2366262	0.78214194	ko04361	ENSGALG00000012890(DGKI);ENSGALG00000006647(DUSP8)	K00901+K04459
Metabolism	Carbohydrate metabolism	Pentose phosphate pathway	1	26	0.238448	0.78214194	ko00030	ENSGALG00000016724(RGN)	K01053
Organismal Systems	Sensory system	Phototransduction - fly	1	26	0.238448	0.78214194	ko04745	ENSGALG00000007647(MYO3A)	K08834
Organismal Systems	Immune system	C-type lectin receptor signaling pathway	2	90	0.2404869	0.78214194	ko04625	ENSGALG00000010915(IL6);ENSGALG00000008346(CASP18)	K05405+K04398
Human Diseases	Cancers	Prostate cancer	2	90	0.2404869	0.78214194	ko05215	ENSGALG00000028318(CDKN1A);ENSGALG00000010625(SRD5A2)	K06625+K12344
Organismal Systems	Environmental adaptation	Circadian entrainment	2	91	0.2443509	0.78214194	ko04713	ENSGALG00000027415(GRIN2C);ENSGALG00000035946(GUCY1A1)	K05211+K12318
Human Diseases	Neurodegenerative disease	Spinocerebellar ataxia	2	94	0.2559587	0.78214194	ko05017	ENSGALG00000027415(GRIN2C);ENSGALG00000002403(ULK1)	K05211+K21357
Organismal Systems	Development	Osteoclast differentiation	2	97	0.2675802	0.78214194	ko04380	ENSGALG00000035804(SQSTM1);ENSGALG00000006707(NOX1)	K14381+K08008
Human Diseases	Infectious diseases	Kaposi sarcoma-associated herpesvirus infection	3	173	0.2682478	0.78214194	ko05167	ENSGALG00000010915(IL6);ENSGALG00000008346(CASP18);ENSGALG00000028318(CDKN1A)	K05405+K04398+K06625
Environmental Information Processing	Signal transduction	HIF-1 signaling pathway	2	99	0.2753298	0.78214194	ko04066	ENSGALG00000010915(IL6);ENSGALG00000028318(CDKN1A)	K05405+K06625
Metabolism	Lipid metabolism	Glycerophospholipid metabolism	2	100	0.2792038	0.78214194	ko00564	ENSGALG00000012890(DGKI);ENSGALG00000012061(-)	K00901+K00006
Human Diseases	Endocrine and metabolic diseases	AGE-RAGE signaling pathway in diabetic complications	2	100	0.2792038	0.78214194	ko04933	ENSGALG00000010915(IL6);ENSGALG00000006707(NOX1)	K05405+K08008
Metabolism	Carbohydrate metabolism	Starch and sucrose metabolism	1	32	0.284954	0.78214194	ko00500	ENSGALG00000054059(-)	K01513
Cellular Processes	Cell growth and death	Apoptosis - multiple species	1	32	0.284954	0.78214194	ko04215	ENSGALG00000008346(CASP18)	K04398
Environmental Information Processing	Signaling molecules and interaction	Neuroactive ligand-receptor interaction	5	344	0.2867924	0.78214194	ko04080	ENSGALG00000013548(GZMA);ENSGALG00000027415(GRIN2C);ENSGALG00000005657(CRHR2);ENSGALG00000011104(GCG);ENSGALG00000012419(-)	K01352+K05211+K04579+K05259+K04241
Metabolism	Amino acid metabolism	Alanine, aspartate and glutamate metabolism	1	33	0.292428	0.78214194	ko00250	ENSGALG00000003432(AGXT2)	K00827
Human Diseases	Cancers	Thyroid cancer	1	33	0.292428	0.78214194	ko05216	ENSGALG00000028318(CDKN1A)	K06625
Human Diseases	Endocrine and metabolic diseases	Insulin resistance	2	105	0.2985512	0.78214194	ko04931	ENSGALG00000010915(IL6);ENSGALG00000006670(PPP1R3C)	K05405+K07189
Human Diseases	Cancers	Viral carcinogenesis	3	185	0.3024445	0.78214194	ko05203	ENSGALG00000010770(SCIN);ENSGALG00000008346(CASP18);ENSGALG00000028318(CDKN1A)	K05768+K04398+K06625
Metabolism	Amino acid metabolism	Tyrosine metabolism	1	35	0.3071456	0.78214194	ko00350	ENSGALG00000006482(FAH)	K01555
Organismal Systems	Digestive system	Fat digestion and absorption	1	35	0.3071456	0.78214194	ko04975	ENSGALG00000015433(ABCA1)	K05641
Metabolism	Xenobiotics biodegradation and metabolism	Drug metabolism - cytochrome P450	1	36	0.3143909	0.78214194	ko00982	ENSGALG00000006344(GSTT1)	K00799
Metabolism	Xenobiotics biodegradation and metabolism	Metabolism of xenobiotics by cytochrome P450	1	37	0.3215615	0.78214194	ko00980	ENSGALG00000006344(GSTT1)	K00799
Organismal Systems	Immune system	Toll and Imd signaling pathway	1	38	0.3286581	0.78214194	ko04624	ENSGALG00000008346(CASP18)	K04398
Human Diseases	Infectious diseases	Chagas disease (American trypanosomiasis)	2	114	0.3331663	0.78214194	ko05142	ENSGALG00000010915(IL6);ENSGALG00000008346(CASP18)	K05405+K04398
Metabolism	Metabolism of cofactors and vitamins	Nicotinate and nicotinamide metabolism	1	39	0.3356816	0.78214194	ko00760	ENSGALG00000054059(-)	K01513
Human Diseases	Substance dependence	Nicotine addiction	1	40	0.3426326	0.78214194	ko05033	ENSGALG00000027415(GRIN2C)	K05211
Metabolism	Lipid metabolism	Steroid hormone biosynthesis	1	41	0.3495119	0.78214194	ko00140	ENSGALG00000010625(SRD5A2)	K12344
Metabolism	Metabolism of cofactors and vitamins	Retinol metabolism	1	41	0.3495119	0.78214194	ko00830	ENSGALG00000030376(DHRS3)	K11146
Environmental Information Processing	Signal transduction	cAMP signaling pathway	3	205	0.3598342	0.78214194	ko04024	ENSGALG00000027415(GRIN2C);ENSGALG00000012163(BDNF);ENSGALG00000011104(GCG)	K05211+K04355+K05259
Human Diseases	Endocrine and metabolic diseases	Type II diabetes mellitus	1	43	0.3630583	0.78214194	ko04930	ENSGALG00000020505(KCNJ11)	K05004
Human Diseases	Immune diseases	Graft-versus-host disease	1	43	0.3630583	0.78214194	ko05332	ENSGALG00000010915(IL6)	K05405
Human Diseases	Cancers	Proteoglycans in cancer	3	208	0.3684206	0.78214194	ko05205	ENSGALG00000028318(CDKN1A);ENSGALG00000009626(THBS1);ENSGALG00000040842(HSPB2)	K06625+K16857+K09543
Human Diseases	Neurodegenerative diseases	Amyotrophic lateral sclerosis (ALS)	1	45	0.3763266	0.78214194	ko05014	ENSGALG00000027415(GRIN2C)	K05211
Metabolism	Amino acid metabolism	Valine, leucine and isoleucine degradation	1	46	0.3828582	0.78214194	ko00280	ENSGALG00000003432(AGXT2)	K00827
Metabolism	Amino acid metabolism	Arginine and proline metabolism	1	46	0.3828582	0.78214194	ko00330	ENSGALG00000023435(GATM)	K00613
Metabolism	Metabolism of other amino acids	Glutathione metabolism	1	46	0.3828582	0.78214194	ko00480	ENSGALG00000006344(GSTT1)	K00799
Cellular Processes	Cell growth and death	Apoptosis - fly	1	47	0.3893223	0.78214194	ko04214	ENSGALG00000008346(CASP18)	K04398
Human Diseases	Infectious diseases	Human cytomegalovirus infection	3	217	0.3940627	0.78214194	ko05163	ENSGALG00000010915(IL6);ENSGALG00000008346(CASP18);ENSGALG00000028318(CDKN1A)	K05405+K04398+K06625
Organismal Systems	Digestive system	Cholesterol metabolism	1	48	0.3957197	0.78214194	ko04979	ENSGALG00000015433(ABCA1)	K05641
Human Diseases	Cancers	Chemical carcinogenesis	1	48	0.3957197	0.78214194	ko05204	ENSGALG00000006344(GSTT1)	K00799
Cellular Processes	Transport and catabolism	Autophagy - animal	2	131	0.3971159	0.78214194	ko04140	ENSGALG00000035804(SQSTM1);ENSGALG00000002403(ULK1)	K14381+K21357
Cellular Processes	Cellular community - eukaryotes	Signaling pathways regulating pluripotency of stem cells	2	132	0.4007987	0.78214194	ko04550	ENSGALG00000009129(DLX5);ENSGALG00000035317(ID3)	K18489+K17694
Human Diseases	Endocrine and metabolic diseases	Non-alcoholic fatty liver disease (NAFLD)	2	134	0.4081335	0.78214194	ko04932	ENSGALG00000010915(IL6);ENSGALG00000008346(CASP18)	K05405+K04398
Organismal Systems	Immune system	Cytosolic DNA-sensing pathway	1	51	0.4145182	0.78214194	ko04623	ENSGALG00000010915(IL6)	K05405
Human Diseases	Cancers	Endometrial cancer	1	52	0.4206553	0.78214194	ko05213	ENSGALG00000028318(CDKN1A)	K06625
Environmental Information Processing	Signaling molecules and interaction	Cytokine-cytokine receptor interaction	3	228	0.4250575	0.78214194	ko04060	ENSGALG00000010915(IL6);ENSGALG00000030526(IL1R1);MSTRG.12907(--)	K05405+K05172+K05469
Metabolism	Nucleotide metabolism	Purine metabolism	2	139	0.4262836	0.78214194	ko00230	ENSGALG00000035946(GUCY1A1);ENSGALG00000054059(-)	K12318+K01513
Cellular Processes	Cell growth and death	Necroptosis	2	139	0.4262836	0.78214194	ko04217	ENSGALG00000035804(SQSTM1);ENSGALG00000008346(CASP18)	K14381+K04398
Human Diseases	Endocrine and metabolic diseases	Cushing syndrome	2	139	0.4262836	0.78214194	ko04934	ENSGALG00000028318(CDKN1A);ENSGALG00000005657(CRHR2)	K06625+K04579
Human Diseases	Cancers	Gastric cancer	2	140	0.4298802	0.78214194	ko05226	ENSGALG00000028318(CDKN1A);ENSGALG00000053916(ABCB1)	K06625+K05658
Organismal Systems	Endocrine system	GnRH secretion	1	54	0.43274	0.78214194	ko04929	ENSGALG00000020505(KCNJ11)	K05004
Human Diseases	Substance dependence	Alcoholism	2	141	0.4334653	0.78214194	ko05034	ENSGALG00000027415(GRIN2C);ENSGALG00000012163(BDNF)	K05211+K04355
Organismal Systems	Immune system	NOD-like receptor signaling pathway	2	145	0.4476877	0.78214194	ko04621	ENSGALG00000010915(IL6);ENSGALG00000008346(CASP18)	K05405+K04398
Environmental Information Processing	Signal transduction	mTOR signaling pathway	2	146	0.451213	0.78214194	ko04150	ENSGALG00000002403(ULK1);ENSGALG00000007964(CASTOR1)	K21357+K23080
Organismal Systems	Digestive system	Bile secretion	1	58	0.4561686	0.78214194	ko04976	ENSGALG00000053916(ABCB1)	K05658
Environmental Information Processing	Signal transduction	Jak-STAT signaling pathway	2	148	0.4582266	0.78214194	ko04630	ENSGALG00000010915(IL6);ENSGALG00000028318(CDKN1A)	K05405+K06625
Human Diseases	Neurodegenerative diseases	Huntington disease	3	242	0.4637325	0.78214194	ko05016	ENSGALG00000002403(ULK1);ENSGALG00000012163(BDNF);ENSGALG00000008346(CASP18)	K21357+K04355+K04398
Metabolism	Xenobiotics biodegradation and metabolism	Drug metabolism - other enzymes	1	60	0.4675226	0.78214194	ko00983	ENSGALG00000006344(GSTT1)	K00799
Human Diseases	Substance dependence	Amphetamine addiction	1	60	0.4675226	0.78214194	ko05031	ENSGALG00000027415(GRIN2C)	K05211
Metabolism	Nucleotide metabolism	Pyrimidine metabolism	1	61	0.4731117	0.78214194	ko00240	ENSGALG00000054059(-)	K01513
Organismal Systems	Nervous system	Long-term potentiation	1	61	0.4731117	0.78214194	ko04720	ENSGALG00000027415(GRIN2C)	K05211
Human Diseases	Cancers	Basal cell carcinoma	1	61	0.4731117	0.78214194	ko05217	ENSGALG00000028318(CDKN1A)	K06625
Human Diseases	Infectious diseases	Pertussis	1	62	0.4786429	0.78214194	ko05133	ENSGALG00000010915(IL6)	K05405
Human Diseases	Cancers	Renal cell carcinoma	1	62	0.4786429	0.78214194	ko05211	ENSGALG00000028318(CDKN1A)	K06625
Environmental Information Processing	Signaling molecules and interaction	Cell adhesion molecules (CAMs)	2	156	0.4857676	0.78214194	ko04514	ENSGALG00000001621(CLDN5);ENSGALG00000031794(-)	K06087+K06708
Human Diseases	Cancers	Transcriptional misregulation in cancers	3	251	0.4880239	0.78214194	ko05202	ENSGALG00000010915(IL6);ENSGALG00000013568(NR4A3);ENSGALG00000028318(CDKN1A)	K05405+K08559+K06625
Human Diseases	Cancers	Melanoma	1	64	0.4895342	0.78214194	ko05218	ENSGALG00000028318(CDKN1A)	K06625
Human Diseases	Cancers	Non-small cell lung cancer	1	64	0.4895342	0.78214194	ko05223	ENSGALG00000028318(CDKN1A)	K06625
Environmental Information Processing	Signaling molecules and interaction	Viral protein interaction with cytokine and cytokine receptor	1	65	0.4948954	0.78214194	ko04061	ENSGALG00000010915(IL6)	K05405
Organismal Systems	Immune system	RIG-I-like receptor signaling pathway	1	67	0.5054519	0.78214194	ko04622	ENSGALG00000008346(CASP18)	K04398
Environmental Information Processing	Signal transduction	cGMP - PKG signaling pathway	2	162	0.5058616	0.78214194	ko04022	ENSGALG00000035946(GUCY1A1);ENSGALG00000026373(KCNJ8)	K12318+K05001
Metabolism	Lipid metabolism	Glycerolipid metabolism	1	68	0.5106483	0.78214194	ko00561	ENSGALG00000012890(DGKI)	K00901
Organismal Systems	Nervous system	Long-term depression	1	68	0.5106483	0.78214194	ko04730	ENSGALG00000035946(GUCY1A1)	K12318
Organismal Systems	Digestive system	Salivary secretion	1	68	0.5106483	0.78214194	ko04970	ENSGALG00000035946(GUCY1A1)	K12318
Human Diseases	Immune diseases	Inflammatiory bowel disease (IBD)	1	68	0.5106483	0.78214194	ko05321	ENSGALG00000010915(IL6)	K05405
Organismal Systems	Aging	Longevity regulating pathway - worm	1	69	0.5157909	0.78214194	ko04212	ENSGALG00000006344(GSTT1)	K00799
Human Diseases	Cancers	Pancreatic cancer	1	69	0.5157909	0.78214194	ko05212	ENSGALG00000028318(CDKN1A)	K06625
Human Diseases	Cancers	Chronic myeloid leukemia	1	72	0.5309011	0.79303402	ko05220	ENSGALG00000028318(CDKN1A)	K06625
Human Diseases	Cardiovascular diseases	Dilated cardiomyopathy (DCM)	2	170	0.5318705	0.79303402	ko05414	ENSGALG00000052741(-);ENSGALG00000052907(-)	K12567+K12567
Human Diseases	Cancers	Glioma	1	73	0.5358338	0.79303402	ko05214	ENSGALG00000028318(CDKN1A)	K06625
Organismal Systems	Immune system	Complement and coagulation cascades	1	74	0.5407153	0.79390738	ko04610	ENSGALG00000016833(F7)	K01320
Environmental Information Processing	Signal transduction	MAPK signaling pathway	3	276	0.5526319	0.79965662	ko04010	ENSGALG00000012163(BDNF);ENSGALG00000006647(DUSP8);ENSGALG00000040360(DUSP1)	K04355+K04459+K21278
Human Diseases	Infectious diseases	Pathogenic Escherichia coli infection	3	277	0.5551191	0.79965662	ko05130	ENSGALG00000001621(CLDN5);ENSGALG00000010915(IL6);ENSGALG00000008346(CASP18)	K06087+K05405+K04398
Human Diseases	Infectious diseases	Epstein-Barr virus infection	3	278	0.5575984	0.79965662	ko05169	ENSGALG00000010915(IL6);ENSGALG00000008346(CASP18);ENSGALG00000028318(CDKN1A)	K05405+K04398+K06625
Human Diseases	Cancers	Colorectal cancer	1	82	0.5779885	0.82252210	ko05210	ENSGALG00000028318(CDKN1A)	K06625
Organismal Systems	Aging	Longevity regulating pathway - mammal	1	84	0.5868308	0.82666021	ko04211	ENSGALG00000002403(ULK1)	K21357
Organismal Systems	Endocrine system	Glucagon signaling pathway	1	89	0.6081455	0.82666021	ko04922	ENSGALG00000011104(GCG)	K05259
Environmental Information Processing	Signal transduction	PI3K-Akt signaling pathway	4	403	0.6111514	0.82666021	ko04151	ENSGALG00000010915(IL6);ENSGALG00000012163(BDNF);ENSGALG00000028318(CDKN1A);ENSGALG00000009626(THBS1)	K05405+K04355+K06625+K16857
Cellular Processes	Cellular community - eukaryotes	Gap junction	1	91	0.6163646	0.82666021	ko04540	ENSGALG00000035946(GUCY1A1)	K12318
Organismal Systems	Digestive system	Pancreatic secretion	1	91	0.6163646	0.82666021	ko04972	ENSGALG00000050155(CLCA2)	K05028
Human Diseases	Cancers	Small cell lung cancer	1	91	0.6163646	0.82666021	ko05222	ENSGALG00000028318(CDKN1A)	K06625
Metabolism	Global and overview maps	Metabolic pathways	14	1406	0.6205806	0.82666021	ko01100	ENSGALG00000006482(FAH);ENSGALG00000047947(-);ENSGALG00000008930(B3GNT2);ENSGALG00000012890(DGKI);ENSGALG00000035946(GUCY1A1);ENSGALG00000054059(-);ENSGALG00000052712(-);ENSGALG00000011414(AMDHD1);ENSGALG00000006344(GSTT1);ENSGALG00000030376(DHRS3);ENSGALG00000048035(GCNT2);ENSGALG00000003432(AGXT2);ENSGALG00000016724(RGN);ENSGALG00000023435(GATM)	K01555+K00789+K00741+K00901+K12318+K01513+K00789+K01468+K00799+K11146+K00742+K00827+K01053+K00613
Environmental Information Processing	Signaling molecules and interaction	ECM-receptor interaction	1	93	0.6244137	0.82666021	ko04512	ENSGALG00000009626(THBS1)	K16857
Organismal Systems	Immune system	Th1 and Th2 cell differentiation	1	95	0.6322962	0.82666021	ko04658	ENSGALG00000009020(JAG1)	K06052
Organismal Systems	Endocrine system	Parathyroid hormone synthesis, secretion and action	1	96	0.6361761	0.82666021	ko04928	ENSGALG00000028318(CDKN1A)	K06625
Human Diseases	Infectious diseases	HTLV-I infection	2	208	0.6425434	0.82666021	ko05166	ENSGALG00000010915(IL6);ENSGALG00000028318(CDKN1A)	K05405+K06625
Environmental Information Processing	Signal transduction	Phosphatidylinositol signaling system	1	100	0.6512962	0.82666021	ko04070	ENSGALG00000012890(DGKI)	K00901
Organismal Systems	Nervous system	Glutamatergic synapse	1	100	0.6512962	0.82666021	ko04724	ENSGALG00000027415(GRIN2C)	K05211
Human Diseases	Infectious diseases	Salmonella infection	2	212	0.6529379	0.82666021	ko05132	ENSGALG00000010915(IL6);ENSGALG00000008346(CASP18)	K05405+K04398
Organismal Systems	Nervous system	Serotonergic synapse	1	101	0.6549784	0.82666021	ko04726	ENSGALG00000040360(DUSP1)	K21278
Metabolism	Global and overview maps	Carbon metabolism	1	103	0.6622282	0.82666021	ko01200	ENSGALG00000016724(RGN)	K01053
Human Diseases	Infectious diseases	Toxoplasmosis	1	103	0.6622282	0.82666021	ko05145	ENSGALG00000008346(CASP18)	K04398
Organismal Systems	Nervous system	Cholinergic synapse	1	104	0.6657966	0.82666021	ko04725	ENSGALG00000004721(-)	K05005
Human Diseases	Cancers	Choline metabolism in cancer	1	104	0.6657966	0.82666021	ko05231	ENSGALG00000012890(DGKI)	K00901
Human Diseases	Infectious diseases	African trypanosomiasis	1	109	0.6830885	0.83502837	ko05143	ENSGALG00000010915(IL6)	K05405
Organismal Systems	Immune system	Th17 cell differentiation	1	111	0.6897557	0.83502837	ko04659	ENSGALG00000010915(IL6)	K05405
Human Diseases	Infectious diseases	Herpes simplex infection	2	228	0.6921661	0.83502837	ko05168	ENSGALG00000010915(IL6);ENSGALG00000008346(CASP18)	K05405+K04398
Environmental Information Processing	Signal transduction	AMPK signaling pathway	1	115	0.7026778	0.83502837	ko04152	ENSGALG00000002403(ULK1)	K21357
Organismal Systems	Immune system	Leukocyte transendothelial migration	1	115	0.7026778	0.83502837	ko04670	ENSGALG00000001621(CLDN5)	K06087
Organismal Systems	Nervous system	Neurotrophin signaling pathway	1	115	0.7026778	0.83502837	ko04722	ENSGALG00000012163(BDNF)	K04355
Organismal Systems	Nervous system	Dopaminergic synapse	1	117	0.7089385	0.83502837	ko04728	ENSGALG00000010943(-)	K04833
Cellular Processes	Cell growth and death	Cell cycle	1	119	0.7150691	0.83502837	ko04110	ENSGALG00000028318(CDKN1A)	K06625
Human Diseases	Infectious diseases	Tuberculosis	2	242	0.7234867	0.83502837	ko05152	ENSGALG00000010915(IL6);ENSGALG00000008346(CASP18)	K05405+K04398
Cellular Processes	Transport and catabolism	Lysosome	1	126	0.7355408	0.83502837	ko04142	ENSGALG00000003217(LITAF)	K19363
Organismal Systems	Circulatory system	Vascular smooth muscle contraction	1	126	0.7355408	0.83502837	ko04270	ENSGALG00000035946(GUCY1A1)	K12318
Organismal Systems	Immune system	Platelet activation	1	126	0.7355408	0.83502837	ko04611	ENSGALG00000035946(GUCY1A1)	K12318
Human Diseases	Infectious disease: bacterial	Yersinia infection	1	127	0.7383444	0.83502837	ko05135	ENSGALG00000010915(IL6)	K05405
Environmental Information Processing	Signal transduction	Apelin signaling pathway	1	128	0.7411187	0.83502837	ko04371	ENSGALG00000009020(JAG1)	K06052
Organismal Systems	Immune system	Intestinal immune network for IgA production	1	128	0.7411187	0.83502837	ko04672	ENSGALG00000010915(IL6)	K05405
Cellular Processes	Cell growth and death	Apoptosis	1	131	0.7492687	0.83502837	ko04210	ENSGALG00000008346(CASP18)	K04398
Organismal Systems	Endocrine system	Insulin signaling pathway	1	131	0.7492687	0.83502837	ko04910	ENSGALG00000006670(PPP1R3C)	K07189
Genetic Information Processing	Folding, sorting and degradation	Ubiquitin mediated proteolysis	1	138	0.7673149	0.85001950	ko04120	MSTRG.9359(--)	K10456
Organismal Systems	Immune system	B cell receptor signaling pathway	1	142	0.7770457	0.85567532	ko04662	ENSGALG00000002383(CD72AG)	K06504
Human Diseases	Cardiovascular diseases	Viral myocarditis	1	148	0.7908945	0.86577209	ko05416	ENSGALG00000008346(CASP18)	K04398
Organismal Systems	Immune system	Hematopoietic cell lineage	1	169	0.8330109	0.88944172	ko04640	ENSGALG00000010915(IL6)	K05405
Cellular Processes	Cellular community - eukaryotes	Tight junction	1	170	0.8347928	0.88944172	ko04530	ENSGALG00000001621(CLDN5)	K06087
Human Diseases	Infectious diseases	Amoebiasis	1	170	0.8347928	0.88944172	ko05146	ENSGALG00000010915(IL6)	K05405
Human Diseases	Immune diseases	Rheumatoid arthritis	1	170	0.8347928	0.88944172	ko05323	ENSGALG00000010915(IL6)	K05405
Organismal Systems	Immune system	Fc gamma R-mediated phagocytosis	1	171	0.836556	0.88944172	ko04666	ENSGALG00000010770(SCIN)	K05768
Environmental Information Processing	Signal transduction	Rap1 signaling pathway	1	199	0.879051	0.91230798	ko04015	ENSGALG00000009626(THBS1)	K16857
Cellular Processes	Cell motility	Regulation of actin cytoskeleton	1	201	0.8816304	0.91230798	ko04810	ENSGALG00000010770(SCIN)	K05768
Cellular Processes	Cellular community - eukaryotes	Focal adhesion	1	203	0.8841555	0.91230798	ko04510	ENSGALG00000009626(THBS1)	K16857
Human Diseases	Infectious disease: viral	Human immunodeficiency virus 1 infection	1	203	0.8841555	0.91230798	ko05170	ENSGALG00000008346(CASP18)	K04398
Organismal Systems	Environmental adaptation	Thermogenesis	1	205	0.8866276	0.91230798	ko04714	ENSGALG00000011104(GCG)	K05259
Environmental Information Processing	Signal transduction	Ras signaling pathway	1	210	0.8925824	0.91230798	ko04014	ENSGALG00000012163(BDNF)	K04355
Human Diseases	Infectious diseases	Shigellosis	1	210	0.8925824	0.91230798	ko05131	ENSGALG00000035804(SQSTM1)	K14381
Cellular Processes	Transport and catabolism	Phagosome	1	227	0.9106138	0.92439567	ko04145	ENSGALG00000009626(THBS1)	K16857
Environmental Information Processing	Signal transduction	Phospholipase D signaling pathway	1	231	0.9144022	0.92439567	ko04072	ENSGALG00000012890(DGKI)	K00901
Cellular Processes	Transport and catabolism	Endocytosis	1	241	0.9231947	0.92821206	ko04144	ENSGALG00000010293(RBP)	K13649
Environmental Information Processing	Signal transduction	Calcium signaling pathway	1	280	0.9497525	0.94975250	ko04020	ENSGALG00000027415(GRIN2C)	K05211