Accession,Description,Exp. q-value: Combined,Sum PEP Score,Coverage [%],# Peptides,# PSMs,# Unique Peptides,# AAs,MW [kDa],calc. pI,Score MSPepSearch: MSPepSearch,Score Sequest HT: Sequest HT,# Peptides (by Search Engine): MSPepSearch,# Peptides (by Search Engine): Sequest HT,Biological Process,Cellular Component,Molecular Function,Pfam IDs,Entrez Gene ID,Ensembl Gene ID,Gene Symbol,Chromosome,KEGG Pathways,WikiPathways,Reactome Pathways,# Protein Pathway Groups,"Found in Sample: [S3] F3: Sample, Apex",# Protein Groups
Q8WZ42,Titin OS=Homo sapiens OX=9606 GN=TTN PE=1 SV=4,0,26099.175,62,2043,128236,26,34350,3813.7,6.35,61941301,20120.13,1676,950,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,chromosome;cytoplasm;cytosol;extracellular;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding;structural molecule activity,"Pf00041, Pf00047, Pf00069, Pf02818, Pf07679, Pf07686, Pf07714, Pf09042, Pf10446, Pf13895, Pf13927",7273,ENSG00000155657.26,TTN,2,Dilated cardiomyopathy; Hypertrophic cardiomyopathy (HCM),Striated Muscle Contraction,Platelet degranulation ; Striated Muscle Contraction,9,High,1
Q8WZ42-5,Isoform 5 of Titin OS=Homo sapiens OX=9606 GN=TTN,0,25859.527,64,2012,126619,4,32900,3650.8,6.46,61176559,19991.46,1650,940,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,chromosome;cytosol;extracellular,catalytic activity;metal ion binding;nucleotide binding;protein binding;structural molecule activity,"Pf00041, Pf00047, Pf00069, Pf07679, Pf07686, Pf07714, Pf09042, Pf10446, Pf13895, Pf13927",7273,,TTN,2,,Striated Muscle Contraction,,1,High,1
Q8WZ42-3,Isoform 3 of Titin OS=Homo sapiens OX=9606 GN=TTN,0,23840.611,68,1803,121211,1,26926,2991.1,6.74,58768500,18226.03,1499,839,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,chromosome;cytosol;extracellular,catalytic activity;metal ion binding;nucleotide binding;protein binding;structural molecule activity,"Pf00041, Pf00047, Pf00069, Pf07679, Pf07714, Pf09042, Pf10446, Pf13895, Pf13927",7273,ENSG00000155657.26,TTN,2,,Striated Muscle Contraction,,1,High,1
P12883,Myosin-7 OS=Homo sapiens OX=9606 GN=MYH7 PE=1 SV=5,0,6917.952,76,459,161121,155,1935,223,5.8,83102108,10550.16,422,151,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;nucleus,catalytic activity;DNA binding;motor activity;nucleotide binding;protein binding;structural molecule activity,"Pf00038, Pf00063, Pf01576, Pf02736, Pf04111, Pf04156, Pf05483, Pf05557, Pf06160, Pf07888, Pf09726, Pf12128, Pf13166, Pf13514, Pf13851",4625,ENSG00000092054.12,MYH7,14,Dilated cardiomyopathy; Viral myocarditis; Hypertrophic cardiomyopathy (HCM); cGMP-PKG signaling pathway; Tight junction; Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes,,Translocation of GLUT4 to the plasma membrane,10,High,1
P13533,Myosin-6 OS=Homo sapiens OX=9606 GN=MYH6 PE=1 SV=5,0,4814.369,67,326,95150,42,1939,223.6,5.73,49031783,5730.54,296,119,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process,cytoplasm;cytosol,catalytic activity;motor activity;nucleotide binding;protein binding;structural molecule activity,"Pf00038, Pf00063, Pf01576, Pf02736, Pf04111, Pf07888, Pf09726, Pf10186, Pf12128, Pf12718, Pf13514",4624,ENSG00000197616.11,MYH6,14,Viral myocarditis; Tight junction; Thyroid hormone signaling pathway; Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; Dilated cardiomyopathy; Hypertrophic cardiomyopathy (HCM),Cardiac Progenitor Differentiation; Striated Muscle Contraction,Translocation of GLUT4 to the plasma membrane; Striated Muscle Contraction,14,High,1
Q8WZ42-6,Isoform 6 of Titin OS=Homo sapiens OX=9606 GN=TTN,0,3405.185,53,270,16273,53,5604,631.2,5.73,7626884,2811.82,186,148,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,chromosome;cytosol;extracellular,catalytic activity;metal ion binding;nucleotide binding;protein binding;structural molecule activity,"Pf00047, Pf07679, Pf07686, Pf09042, Pf13895, Pf13927",7273,ENSG00000155657.26,TTN,2,,Striated Muscle Contraction,,1,High,1
Q14315-2,Isoform 2 of Filamin-C OS=Homo sapiens OX=9606 GN=FLNC,0,3096.191,79,261,14239,1,2692,287.1,5.97,6765897,1770.67,223,81,cell organization and biogenesis,cytoplasm;cytoskeleton;cytosol;membrane,protein binding,"Pf00307, Pf00630",2318,ENSG00000128591.15,FLNC,7,,,,0,High,1
Q14315,Filamin-C OS=Homo sapiens OX=9606 GN=FLNC PE=1 SV=3,0,3085.046,79,264,14351,4,2725,290.8,5.97,6843608,1648.95,226,81,cell organization and biogenesis,cytoplasm;cytoskeleton;cytosol;membrane,protein binding,"Pf00307, Pf00630",2318,ENSG00000128591.15,FLNC,7,Proteoglycans in cancer; MAPK signaling pathway; Salmonella infection; Focal adhesion,,Cell-extracellular matrix interactions,7,High,1
Q15149,Plectin OS=Homo sapiens OX=9606 GN=PLEC PE=1 SV=3,0,3026.575,57,288,7733,2,4684,531.5,5.96,3823409,80.6,283,37,cell organization and biogenesis,cytoplasm;cytoskeleton;cytosol;membrane,protein binding;RNA binding;structural molecule activity,"Pf00307, Pf00681, Pf03501, Pf07812",5339,ENSG00000178209.14,PLEC,8,,,Assembly of collagen fibrils and other multimeric structures; Caspase-mediated cleavage of cytoskeletal proteins; Type I hemidesmosome assembly,11,High,1
Q15149-9,Isoform 9 of Plectin OS=Homo sapiens OX=9606 GN=PLEC,0,3022.037,59,287,7734,1,4533,514.5,5.73,3822528,86,281,38,cell organization and biogenesis,cytoplasm;cytoskeleton;cytosol;membrane,protein binding;RNA binding;structural molecule activity,"Pf00307, Pf00681, Pf07812",5339,ENSG00000178209.14,PLEC,8,,,,0,High,1
Q15149-8,Isoform 8 of Plectin OS=Homo sapiens OX=9606 GN=PLEC,0,3021.231,59,287,7732,1,4525,513.4,5.76,3822528,84.68,281,38,cell organization and biogenesis,cytoplasm;cytoskeleton;cytosol;membrane,protein binding;RNA binding;structural molecule activity,"Pf00307, Pf00681, Pf07812",5339,ENSG00000178209.14,PLEC,8,,,,0,High,1
Q15149-3,Isoform 3 of Plectin OS=Homo sapiens OX=9606 GN=PLEC,0,3015.042,58,285,7711,1,4570,517.7,5.74,3808774,109.3,279,38,cell organization and biogenesis,cytoplasm;cytoskeleton;cytosol;membrane,protein binding;RNA binding;structural molecule activity,"Pf00307, Pf00681, Pf07812",5339,ENSG00000178209.14,PLEC,8,,,,0,High,1
Q09666,Neuroblast differentiation-associated protein AHNAK OS=Homo sapiens OX=9606 GN=AHNAK PE=1 SV=2,0,2786.088,76,303,6240,302,5890,628.7,6.15,2953967,22.67,301,36,cell organization and biogenesis;regulation of biological process,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,protein binding;RNA binding;structural molecule activity,,79026,ENSG00000124942.13,AHNAK,11,,,,0,High,1
P62736,"Actin, aortic smooth muscle OS=Homo sapiens OX=9606 GN=ACTA2 PE=1 SV=1",0,2782.698,92,186,51024,3,377,42,5.39,28282753,2006.79,184,19,regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol,nucleotide binding;protein binding,Pf00022,59,ENSG00000107796.13,ACTA2,10,Vascular smooth muscle contraction,Myometrial Relaxation and Contraction Pathways; Striated Muscle Contraction,Smooth Muscle Contraction,5,High,1
P68133,"Actin, alpha skeletal muscle OS=Homo sapiens OX=9606 GN=ACTA1 PE=1 SV=1",0,2738.309,97,187,66759,15,377,42,5.39,36532455,2112.82,181,24,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol,nucleotide binding;protein binding;structural molecule activity,Pf00022,58,ENSG00000143632.14,ACTA1,1,,Myometrial Relaxation and Contraction Pathways; Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation; Association Between Physico-Chemical Features and Toxicity Associated Pathways; Striated Muscle Contraction,Striated Muscle Contraction,6,High,1
P63267,"Actin, gamma-enteric smooth muscle OS=Homo sapiens OX=9606 GN=ACTG2 PE=1 SV=1",0,2650.84,92,180,49370,1,376,41.9,5.48,27409884,1985.19,180,15,regulation of biological process,cytoplasm;cytoskeleton;cytosol,nucleotide binding,Pf00022,72,ENSG00000163017.13,ACTG2,2,Vascular smooth muscle contraction,Common Pathways Underlying Drug Addiction,Smooth Muscle Contraction,4,High,1
Q14204,Cytoplasmic dynein 1 heavy chain 1 OS=Homo sapiens OX=9606 GN=DYNC1H1 PE=1 SV=5,0,2445.6,55,242,5169,241,4646,532.1,6.4,2458290,108.05,239,25,cell division;cell organization and biogenesis;cellular component movement;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;extracellular;membrane;organelle lumen,catalytic activity;motor activity;nucleotide binding;protein binding;RNA binding,"Pf00769, Pf03028, Pf03915, Pf04156, Pf07246, Pf07728, Pf08385, Pf08393, Pf12774, Pf12775, Pf12777, Pf12780, Pf12781, Pf13173, Pf13207, Pf13401",1778,ENSG00000197102.10,DYNC1H1,14,Salmonella infection; Vasopressin-regulated water reabsorption; Phagosome,,COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Neutrophil degranulation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR),50,High,1
Q13813-3,"Isoform 3 of Spectrin alpha chain, non-erythrocytic 1 OS=Homo sapiens OX=9606 GN=SPTAN1",0,2385.808,66,197,6377,3,2452,282.1,5.34,3253922,93.94,195,29,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoskeleton;cytosol;extracellular;membrane;organelle lumen,metal ion binding;protein binding;structural molecule activity,"Pf00018, Pf00036, Pf00435, Pf07653, Pf08239, Pf08726, Pf13405, Pf13499, Pf14604",6709,ENSG00000197694.15,SPTAN1,9,,Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation,,1,High,1
Q13813-2,"Isoform 2 of Spectrin alpha chain, non-erythrocytic 1 OS=Homo sapiens OX=9606 GN=SPTAN1",0,2375.828,65,196,6371,2,2477,284.9,5.35,3245475,136.66,195,28,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoskeleton;cytosol;extracellular;membrane;organelle lumen,metal ion binding;protein binding;structural molecule activity,"Pf00018, Pf00036, Pf00435, Pf07653, Pf08239, Pf08726, Pf13405, Pf13499, Pf14604",6709,ENSG00000197694.15,SPTAN1,9,,Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation,,1,High,1
P11532,Dystrophin OS=Homo sapiens OX=9606 GN=DMD PE=1 SV=3,0,2151.042,55,187,5336,133,3685,426.5,5.88,2509864,947.47,172,75,cell organization and biogenesis;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;cytoskeleton;cytosol;membrane;nucleus,metal ion binding;protein binding;structural molecule activity,"Pf00307, Pf00397, Pf00435, Pf00569, Pf09068, Pf09069, Pf11971, Pf12761, Pf13166",1756,,DMD,X,Arrhythmogenic right ventricular cardiomyopathy (ARVC); Dilated cardiomyopathy; Viral myocarditis; Hypertrophic cardiomyopathy (HCM),Arrhythmogenic Right Ventricular Cardiomyopathy; Ectoderm Differentiation; Striated Muscle Contraction,Striated Muscle Contraction; Non-integrin membrane-ECM interactions,11,High,1
P06576,"ATP synthase subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1B PE=1 SV=3",0,2068.617,83,153,23969,153,529,56.5,5.4,12357555,209.28,152,21,cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;transport,cell surface;membrane;mitochondrion;nucleus;organelle lumen,catalytic activity;nucleotide binding;protein binding;transporter activity,"Pf00006, Pf00306, Pf02874",506,ENSG00000110955.8,ATP5B,12,Oxidative phosphorylation; Huntington's disease; Alzheimer's disease; Metabolic pathways; Parkinson's disease,Electron Transport Chain; Oxidative phosphorylation,Transcriptional activation of mitochondrial biogenesis; Cristae formation; Mitochondrial protein import; Formation of ATP by chemiosmotic coupling; Metabolism of proteins,17,High,1
P35609,Alpha-actinin-2 OS=Homo sapiens OX=9606 GN=ACTN2 PE=1 SV=1,0,2042.886,89,152,21718,100,894,103.8,5.45,10996102,1910.68,128,61,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;extracellular;membrane;organelle lumen,metal ion binding;protein binding;structural molecule activity,"Pf00307, Pf00435, Pf08726, Pf11971, Pf13499, Pf13833",88,ENSG00000077522.12,ACTN2,1,Viral carcinogenesis; Leukocyte transendothelial migration; Tight junction; Adherens junction; Amoebiasis; Systemic lupus erythematosus; Regulation of actin cytoskeleton; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy (ARVC),Arrhythmogenic Right Ventricular Cardiomyopathy; Striated Muscle Contraction,"Ras activation uopn Ca2+ infux through NMDA receptor; Platelet degranulation ; Nephrin family interactions; Unblocking of NMDA receptor, glutamate binding and activation; RAF/MAP kinase cascade; CREB phosphorylation through the activation of CaMKII; Striated Muscle Contraction; Interleukin-20 family signaling",36,High,1
Q14896,"Myosin-binding protein C, cardiac-type OS=Homo sapiens OX=9606 GN=MYBPC3 PE=1 SV=4",0,2016.449,82,137,13853,136,1274,140.7,6.65,6763405,2068.05,118,55,cell organization and biogenesis;cellular component movement;regulation of biological process,cytosol,enzyme regulator activity;metal ion binding;protein binding;structural molecule activity,"Pf00041, Pf00047, Pf07679, Pf07686, Pf13895, Pf13927",4607,ENSG00000134571.10,MYBPC3,11,Dilated cardiomyopathy; Hypertrophic cardiomyopathy (HCM),Striated Muscle Contraction,Striated Muscle Contraction,5,High,1
Q01082,"Spectrin beta chain, non-erythrocytic 1 OS=Homo sapiens OX=9606 GN=SPTBN1 PE=1 SV=2",0,1952.587,64,146,4491,134,2364,274.4,5.57,2218914,58.28,141,26,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,protein binding;RNA binding;structural molecule activity,"Pf00169, Pf00307, Pf00435, Pf11971, Pf12128, Pf15410",6711,ENSG00000115306.15,SPTBN1,2,,TGF-beta Signaling Pathway; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,Nephrin family interactions; Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interleukin-20 family signaling,25,High,1
P98160,Basement membrane-specific heparan sulfate proteoglycan core protein OS=Homo sapiens OX=9606 GN=HSPG2 PE=1 SV=4,0,1850.115,39,155,4359,155,4391,468.5,6.51,2143030,266.58,139,29,cell differentiation;cell growth;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane;organelle lumen,metal ion binding;protein binding,"Pf00008, Pf00047, Pf00052, Pf00053, Pf00054, Pf00057, Pf02210, Pf07679, Pf07686, Pf12785, Pf13385, Pf13895, Pf13927",3339,ENSG00000142798.17,HSPG2,1,Hepatitis B; ECM-receptor interaction; Proteoglycans in cancer,,"Integrin cell surface interactions; Defective B4GALT7 causes EDS, progeroid type; Amyloid fiber formation; Retinoid metabolism and transport; Defective EXT2 causes exostoses 2; Non-integrin membrane-ECM interactions; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Signaling by GPCR; HS-GAG biosynthesis; A tetrasaccharide linker sequence is required for GAG synthesis; Laminin interactions; Degradation of the extracellular matrix; Defective B3GALT6 causes EDSP2 and SEMDJL1; HS-GAG degradation; Defective B3GAT3 causes JDSSDHD",32,High,1
P15924,Desmoplakin OS=Homo sapiens OX=9606 GN=DSP PE=1 SV=3,0,1803.868,54,173,5988,172,2871,331.6,6.81,3093861,177.98,161,27,cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;membrane;nucleus,catalytic activity;motor activity;protein binding;RNA binding;structural molecule activity,"Pf00038, Pf00681, Pf01540, Pf01576, Pf02463, Pf04111, Pf04156, Pf05483, Pf05557, Pf05622, Pf06008, Pf06160, Pf06637, Pf07888, Pf10174, Pf12072, Pf12128, Pf13166",1832,ENSG00000096696.13,DSP,6,Arrhythmogenic right ventricular cardiomyopathy (ARVC),Arrhythmogenic Right Ventricular Cardiomyopathy; Lung fibrosis,Apoptotic cleavage of cell adhesion  proteins; Formation of the cornified envelope; Neutrophil degranulation,14,High,1
P69905,Hemoglobin subunit alpha OS=Homo sapiens OX=9606 GN=HBA1 PE=1 SV=2,0,1683.058,100,105,27101,105,142,15.2,8.68,15086222,525.89,105,8,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;extracellular;membrane;organelle lumen,antioxidant activity;catalytic activity;metal ion binding;protein binding;transporter activity,Pf00042,3040; 3039,ENSG00000206172.8; ENSG00000188536.12,HBA2; HBA1,16,African trypanosomiasis; Malaria,Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism; Effects of Nitric Oxide,Scavenging of heme from plasma; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide,13,High,1
Q92736,Ryanodine receptor 2 OS=Homo sapiens OX=9606 GN=RYR2 PE=1 SV=3,0,1644.847,40,157,3676,156,4967,564.2,6.07,1431871,1973.77,110,97,cell communication;cell death;cellular homeostasis;development;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;membrane,metal ion binding;protein binding;transporter activity,"Pf00520, Pf00622, Pf01365, Pf02026, Pf02815, Pf06459, Pf08454, Pf08709, Pf13499, Pf14070",6262,ENSG00000198626.15,RYR2,1,Adrenergic signaling in cardiomyocytes; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Cardiac muscle contraction; Circadian entrainment; Hypertrophic cardiomyopathy (HCM); Dilated cardiomyopathy; cAMP signaling pathway; Pancreatic secretion; Insulin secretion; Oxytocin signaling pathway; Calcium signaling pathway,Arrhythmogenic Right Ventricular Cardiomyopathy; Myometrial Relaxation and Contraction Pathways; Cell-type Dependent Selectivity of CCK2R Signaling; Calcium Regulation in the Cardiac Cell; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,Ion homeostasis; Stimuli-sensing channels,22,High,1
P21333,Filamin-A OS=Homo sapiens OX=9606 GN=FLNA PE=1 SV=4,0,1567.55,59,146,4257,115,2647,280.6,6.06,2133398,125.09,134,27,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus,protein binding;RNA binding;signal transducer activity,"Pf00307, Pf00630",2316,ENSG00000196924.14,FLNA,X,Focal adhesion; Salmonella infection; Proteoglycans in cancer; MAPK signaling pathway,Androgen receptor signaling pathway; Prolactin Signaling Pathway; Focal Adhesion; Hypothesized Pathways in Pathogenesis of Cardiovascular Disease; MAPK Signaling Pathway; IL-4 Signaling Pathway,Platelet degranulation ; RHO GTPases activate PAKs; Cell-extracellular matrix interactions; GP1b-IX-V activation signalling,22,High,1
P04406,Glyceraldehyde-3-phosphate dehydrogenase OS=Homo sapiens OX=9606 GN=GAPDH PE=1 SV=3,0,1550.646,85,111,22901,105,335,36,8.46,10719801,245.7,109,14,cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding,"Pf00044, Pf02800",2597,ENSG00000111640.14,GAPDH,12,Glycolysis / Gluconeogenesis; HIF-1 signaling pathway; Biosynthesis of amino acids; Carbon metabolism; Metabolic pathways; Alzheimer's disease,Cori Cycle; Alzheimers Disease; Glycolysis and Gluconeogenesis; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,Gluconeogenesis; Glycolysis,15,High,1
P63261,"Actin, cytoplasmic 2 OS=Homo sapiens OX=9606 GN=ACTG1 PE=1 SV=1",0,1543.601,97,141,53544,2,375,41.8,5.48,30341131,148.98,139,16,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,nucleotide binding;protein binding;structural molecule activity,Pf00022,71,ENSG00000184009.9,ACTG1,17,Tight junction; Vibrio cholerae infection; Adherens junction; Phagosome; Hippo signaling pathway; Hypertrophic cardiomyopathy (HCM); Leukocyte transendothelial migration; Proteoglycans in cancer; Oxytocin signaling pathway; Shigellosis; Pathogenic Escherichia coli infection; Viral myocarditis; Apoptosis; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Bacterial invasion of epithelial cells; Thyroid hormone signaling pathway; Regulation of actin cytoskeleton; Rap1 signaling pathway; Platelet activation; Salmonella infection; Dilated cardiomyopathy; Influenza A; Focal adhesion,Arrhythmogenic Right Ventricular Cardiomyopathy; Pathogenic Escherichia coli infection; Common Pathways Underlying Drug Addiction; Myometrial Relaxation and Contraction Pathways; Focal Adhesion; Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation; Striated Muscle Contraction; Regulation of Actin Cytoskeleton,Signaling by BRAF and RAF fusions; Formation of annular gap junctions; Cell-extracellular matrix interactions; MAP2K and MAPK activation; Clathrin-mediated endocytosis; Interaction between L1 and Ankyrins; VEGFA-VEGFR2 Pathway; RHO GTPases activate IQGAPs; Signaling by RAS mutants; Recycling pathway of L1; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; Translocation of GLUT4 to the plasma membrane; Adherens junctions interactions; EPH-ephrin mediated repulsion of cells; Paradoxical activation of RAF signaling by kinase inactive BRAF; EPHB-mediated forward signaling; RHO GTPases Activate WASPs and WAVEs; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate Formins; Interleukin-20 family signaling,80,High,1
P60709,"Actin, cytoplasmic 1 OS=Homo sapiens OX=9606 GN=ACTB PE=1 SV=1",0,1543.123,97,141,53569,2,375,41.7,5.48,30340775,233.89,139,16,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,DNA binding;nucleotide binding;protein binding;structural molecule activity,Pf00022,60,ENSG00000075624.13,ACTB,7,Rap1 signaling pathway; Gastric acid secretion; Pathogenic Escherichia coli infection; Adherens junction; Shigellosis; Focal adhesion; Influenza A; Thyroid hormone signaling pathway; Bacterial invasion of epithelial cells; Hippo signaling pathway; Regulation of actin cytoskeleton; Tight junction; Proteoglycans in cancer; Platelet activation; Phagosome; Viral myocarditis; Hypertrophic cardiomyopathy (HCM); Vibrio cholerae infection; Leukocyte transendothelial migration; Salmonella infection; Apoptosis; Oxytocin signaling pathway; Dilated cardiomyopathy; Arrhythmogenic right ventricular cardiomyopathy (ARVC),Arrhythmogenic Right Ventricular Cardiomyopathy; Pathogenic Escherichia coli infection; Common Pathways Underlying Drug Addiction; Myometrial Relaxation and Contraction Pathways; Focal Adhesion; Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation; Regulation of Actin Cytoskeleton,Formation of annular gap junctions; Cell-extracellular matrix interactions; UCH proteinases; MAP2K and MAPK activation; Interaction between L1 and Ankyrins; Factors involved in megakaryocyte development and platelet production; Translocation of GLUT4 to the plasma membrane; EPH-ephrin mediated repulsion of cells; Prefoldin mediated transfer of substrate  to CCT/TriC; EPHB-mediated forward signaling; Paradoxical activation of RAF signaling by kinase inactive BRAF; Folding of actin by CCT/TriC; DNA Damage Recognition in GG-NER; Regulation of actin dynamics for phagocytic cup formation; Interleukin-20 family signaling; Signaling by BRAF and RAF fusions; Clathrin-mediated endocytosis; VEGFA-VEGFR2 Pathway; HATs acetylate histones; RHO GTPases activate IQGAPs; Recycling pathway of L1; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; Adherens junctions interactions; RHO GTPases Activate WASPs and WAVEs; RHO GTPases Activate Formins; B-WICH complex positively regulates rRNA expression,102,High,1
P54296,Myomesin-2 OS=Homo sapiens OX=9606 GN=MYOM2 PE=1 SV=2,0,1541.743,73,100,8558,100,1465,164.8,6.19,3905616,1796.57,82,62,cell organization and biogenesis,cytoplasm;mitochondrion,protein binding;structural molecule activity,"Pf00041, Pf00047, Pf07679, Pf07686, Pf13895, Pf13927",9172,ENSG00000274137.2,MYOM2,8; CHR_HSCHR8_8_CTG1,,,,0,High,1
P12111,Collagen alpha-3(VI) chain OS=Homo sapiens OX=9606 GN=COL6A3 PE=1 SV=5,0,1495.925,51,149,4649,149,3177,343.5,6.68,2343760,16.55,149,22,cell organization and biogenesis;metabolic process;regulation of biological process,extracellular;membrane;organelle lumen,enzyme regulator activity;protein binding,"Pf00014, Pf00041, Pf00092, Pf01391, Pf13519, Pf13768",1293,ENSG00000163359.15,COL6A3,2,ECM-receptor interaction; PI3K-Akt signaling pathway; Protein digestion and absorption; Focal adhesion,miRNA targets in ECM and membrane receptors,ECM proteoglycans; Collagen degradation; Integrin cell surface interactions; Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization; NCAM1 interactions; Signaling by PDGF,21,High,1
P12882,Myosin-1 OS=Homo sapiens OX=9606 GN=MYH1 PE=1 SV=3,0,1491.86,27,129,24933,3,1939,223,5.74,12523718,1188.99,118,36,metabolic process;regulation of biological process,cytoplasm,catalytic activity;motor activity;nucleotide binding;protein binding;structural molecule activity,"Pf00038, Pf00063, Pf01576, Pf02463, Pf02736, Pf04111, Pf05557, Pf05622, Pf07888, Pf08317, Pf09726, Pf10174, Pf12128, Pf13514",4619,ENSG00000109061.9,MYH1,17,Tight junction,,Translocation of GLUT4 to the plasma membrane,4,High,1
Q5VST9-3,Isoform 3 of Obscurin OS=Homo sapiens OX=9606 GN=OBSCN,0,1484.884,35,159,2591,4,6620,721.1,5.74,1007417,1344.11,105,90,cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus,cytosol;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding;structural molecule activity,"Pf00041, Pf00047, Pf00169, Pf00621, Pf07679, Pf07686, Pf13895, Pf13927",84033,ENSG00000154358.20,OBSCN,1,,,,0,High,1
Q5VST9-6,Isoform 5 of Obscurin OS=Homo sapiens OX=9606 GN=OBSCN,0,1473.961,28,162,2581,7,8483,924.4,5.97,1007417,1297.52,105,93,cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus,cytosol;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding;structural molecule activity,"Pf00041, Pf00047, Pf00069, Pf00169, Pf00621, Pf07654, Pf07679, Pf07686, Pf07714, Pf13895, Pf13927",84033,,OBSCN,1,,,,0,High,1
Q9UKX2,Myosin-2 OS=Homo sapiens OX=9606 GN=MYH2 PE=1 SV=1,0,1419.491,25,122,23306,3,1941,222.9,5.82,11688607,1122.1,113,30,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;Golgi,catalytic activity;motor activity;nucleotide binding;protein binding;structural molecule activity,"Pf00038, Pf00063, Pf01576, Pf02463, Pf02736, Pf04111, Pf05622, Pf07888, Pf08317, Pf09726, Pf10174, Pf12128, Pf13514",4620,ENSG00000125414.18,MYH2,17,Tight junction,,Translocation of GLUT4 to the plasma membrane; Regulation of actin dynamics for phagocytic cup formation,8,High,1
Q99798,"Aconitate hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=ACO2 PE=1 SV=2",0,1412.106,79,114,10452,114,780,85.4,7.61,5202820,512.38,105,23,metabolic process;response to stimulus,mitochondrion;organelle lumen,catalytic activity;metal ion binding,"Pf00330, Pf00694",50,ENSG00000100412.15,ACO2,22,2-Oxocarboxylic acid metabolism; Carbon metabolism; Metabolic pathways; Biosynthesis of amino acids; Citrate cycle (TCA cycle); Glyoxylate and dicarboxylate metabolism,Amino Acid metabolism; TCA Cycle,Mitochondrial protein import; Metabolism of proteins; Citric acid cycle (TCA cycle),14,High,1
P52179,Myomesin-1 OS=Homo sapiens OX=9606 GN=MYOM1 PE=1 SV=2,0,1409.949,65,108,7765,108,1685,187.5,6.93,3671452,1736.79,90,64,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm,protein binding;structural molecule activity,"Pf00041, Pf00047, Pf07679, Pf13895, Pf13927",8736,ENSG00000101605.12,MYOM1,18,,Striated Muscle Contraction,,1,High,1
P35579,Myosin-9 OS=Homo sapiens OX=9606 GN=MYH9 PE=1 SV=4,0,1360.705,52,120,3039,92,1960,226.4,5.6,1488454,213.65,117,9,cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus,catalytic activity;motor activity;nucleotide binding;protein binding;RNA binding;transporter activity,"Pf00063, Pf01442, Pf01496, Pf01576, Pf01765, Pf02736, Pf03962, Pf04111, Pf04156, Pf05911, Pf06637, Pf07888, Pf09731, Pf11068, Pf11559, Pf12128, Pf13094",4627,ENSG00000100345.20,MYH9,22,Regulation of actin cytoskeleton; Salmonella infection; Tight junction,Primary Focal Segmental Glomerulosclerosis FSGS; VEGFA-VEGFR2 Signaling Pathway,RHO GTPases activate PAKs; EPHA-mediated growth cone collapse; RHO GTPases Activate ROCKs; Sema4D induced cell migration and growth-cone collapse; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases activate CIT; RHO GTPases activate PKNs,23,High,1
P17661,Desmin OS=Homo sapiens OX=9606 GN=DES PE=1 SV=3,0,1286.524,84,115,13611,105,470,53.5,5.27,7206294,240.78,112,26,cell organization and biogenesis;cellular component movement;regulation of biological process,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,protein binding;structural molecule activity,"Pf00038, Pf03962, Pf04732",1674,ENSG00000175084.11,DES,2,Arrhythmogenic right ventricular cardiomyopathy (ARVC); Hypertrophic cardiomyopathy (HCM); Dilated cardiomyopathy,Arrhythmogenic Right Ventricular Cardiomyopathy; Striated Muscle Contraction,Striated Muscle Contraction,7,High,1
P25705,"ATP synthase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1A PE=1 SV=1",0,1271.454,74,112,14426,112,553,59.7,9.13,7525709,129.77,110,19,cell organization and biogenesis;metabolic process;regulation of biological process;transport,membrane;mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding;RNA binding;transporter activity,"Pf00006, Pf00306, Pf02663, Pf02874, Pf05943",498,ENSG00000152234.15,ATP5A1,18,Oxidative phosphorylation; Huntington's disease; Alzheimer's disease; Metabolic pathways; Parkinson's disease,Electron Transport Chain; Oxidative phosphorylation,Cristae formation; Mitochondrial protein import; Formation of ATP by chemiosmotic coupling; Metabolism of proteins,16,High,1
P01024,Complement C3 OS=Homo sapiens OX=9606 GN=C3 PE=1 SV=2,0,1268.45,66,117,4526,116,1663,187,6.4,2192112,34.36,114,24,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane;organelle lumen,catalytic activity;enzyme regulator activity;protein binding,"Pf00207, Pf01759, Pf01821, Pf01835, Pf07677, Pf07678, Pf07703, Pf10569, Pf11974",718,ENSG00000125730.16,C3,19,Phagosome; Leishmaniasis; Legionellosis; Systemic lupus erythematosus; Pertussis; Chagas disease (American trypanosomiasis); Staphylococcus aureus infection; Complement and coagulation cascades; Tuberculosis; Viral carcinogenesis; Herpes simplex infection,Allograft Rejection; TYROBP Causal Network; Complement Activation; Complement and Coagulation Cascades,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Alternative complement activation; Peptide ligand-binding receptors; Regulation of Complement cascade; Activation of C3 and C5; Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; G alpha (i) signalling events,36,High,1
Q702N8,Xin actin-binding repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=XIRP1 PE=1 SV=1,0,1261.574,67,88,3621,87,1843,198.4,6.15,1508920,1425.3,63,52,cell organization and biogenesis,,protein binding;RNA binding,Pf08043,165904,ENSG00000168334.8,XIRP1,3,,,,0,High,1
Q9Y623,Myosin-4 OS=Homo sapiens OX=9606 GN=MYH4 PE=2 SV=2,0,1254.474,22,106,22962,4,1939,222.9,5.85,11425377,1141.17,97,33,cellular component movement;metabolic process;response to stimulus,cytoplasm,catalytic activity;motor activity;nucleotide binding;protein binding;RNA binding,"Pf00063, Pf01576, Pf02736, Pf04111, Pf05622, Pf07888, Pf08317, Pf12128",4622,ENSG00000264424.1,MYH4,17,Tight junction,,Translocation of GLUT4 to the plasma membrane,4,High,1
P11277-2,"Isoform 2 of Spectrin beta chain, erythrocytic OS=Homo sapiens OX=9606 GN=SPTB",0,1237.227,57,107,1897,99,2328,267.7,5.39,855572,186.19,99,17,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoskeleton;cytosol;Golgi,protein binding;structural molecule activity,"Pf00169, Pf00307, Pf00435, Pf11971, Pf13514, Pf15410",6710,ENSG00000070182.19,SPTB,14,,,,0,High,1
P24043,Laminin subunit alpha-2 OS=Homo sapiens OX=9606 GN=LAMA2 PE=1 SV=4,0,1184.877,35,112,3282,111,3122,343.7,6.4,1582366,199.07,106,28,cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;extracellular;membrane,catalytic activity;motor activity;protein binding;signal transducer activity;structural molecule activity,"Pf00015, Pf00052, Pf00053, Pf00054, Pf00055, Pf00261, Pf00769, Pf01442, Pf01540, Pf01576, Pf01920, Pf02210, Pf02463, Pf03357, Pf04740, Pf04912, Pf05478, Pf05483, Pf05557, Pf05622, Pf05667, Pf05701, Pf06008, Pf06009, Pf06160, Pf07926, Pf08317, Pf10174, Pf10368, Pf12128, Pf12718, Pf12889, Pf13166, Pf13385, Pf13514, Pf13863, Pf13949, Pf14265, Pf15450",3908,ENSG00000196569.11,LAMA2,6,Focal adhesion; Hypertrophic cardiomyopathy (HCM); Arrhythmogenic right ventricular cardiomyopathy (ARVC); Small cell lung cancer; Dilated cardiomyopathy; ECM-receptor interaction; Pathways in cancer; Viral myocarditis; Toxoplasmosis; PI3K-Akt signaling pathway; Amoebiasis,Arrhythmogenic Right Ventricular Cardiomyopathy; Alpha 6 Beta 4 signaling pathway; Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,ECM proteoglycans; Laminin interactions; MET activates PTK2 signaling; Non-integrin membrane-ECM interactions,24,High,1
P11055,Myosin-3 OS=Homo sapiens OX=9606 GN=MYH3 PE=1 SV=3,0,1183.91,21,93,21384,3,1940,223.8,5.81,10565527,1110.46,83,33,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;Golgi,catalytic activity;motor activity;nucleotide binding;protein binding;structural molecule activity;transporter activity,"Pf00038, Pf00063, Pf00261, Pf01496, Pf01576, Pf02463, Pf02736, Pf04111, Pf04156, Pf05557, Pf05622, Pf05667, Pf05701, Pf06160, Pf06637, Pf07888, Pf09726, Pf09730, Pf10174, Pf12128, Pf12718, Pf13514, Pf13851, Pf15070, Pf15254",4621,ENSG00000109063.14,MYH3,17,Tight junction,Striated Muscle Contraction,Translocation of GLUT4 to the plasma membrane; Striated Muscle Contraction,7,High,1
P13535,Myosin-8 OS=Homo sapiens OX=9606 GN=MYH8 PE=1 SV=3,0,1179.673,21,103,20870,3,1937,222.6,5.74,10224914,1108.32,94,30,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process,cytoplasm;cytoskeleton;cytosol,catalytic activity;motor activity;nucleotide binding;protein binding;structural molecule activity,"Pf00063, Pf01576, Pf02463, Pf02736, Pf04111, Pf04156, Pf05557, Pf05622, Pf05667, Pf05701, Pf06160, Pf07888, Pf08317, Pf09726, Pf10174, Pf11932, Pf12128, Pf12718, Pf13094, Pf13514",4626,ENSG00000133020.4,MYH8,17,Tight junction,Striated Muscle Contraction,Translocation of GLUT4 to the plasma membrane; Striated Muscle Contraction,7,High,1
Q9Y490,Talin-1 OS=Homo sapiens OX=9606 GN=TLN1 PE=1 SV=3,0,1166.194,51,100,2342,91,2541,269.6,6.07,1130995,18.92,98,21,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;cytoskeleton;cytosol;extracellular;membrane,protein binding;structural molecule activity,"Pf00373, Pf01608, Pf02174, Pf08913, Pf09141, Pf09379",7094,ENSG00000137076.20,TLN1,9,HTLV-I infection; Platelet activation; Focal adhesion; Rap1 signaling pathway,Integrin-mediated Cell Adhesion; Primary Focal Segmental Glomerulosclerosis FSGS; Focal Adhesion,SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Signaling by BRAF and RAF fusions; MAP2K and MAPK activation; Smooth Muscle Contraction; XBP1(S) activates chaperone genes; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; p130Cas linkage to MAPK signaling for integrins; Platelet degranulation ; Paradoxical activation of RAF signaling by kinase inactive BRAF; Interleukin-20 family signaling,43,High,1
P35749,Myosin-11 OS=Homo sapiens OX=9606 GN=MYH11 PE=1 SV=3,0,1155.591,50,116,2199,2,1972,227.2,5.5,996655,206.94,113,16,cell organization and biogenesis;metabolic process;transport,cytoskeleton;cytosol;extracellular,catalytic activity;motor activity;nucleotide binding;protein binding;structural molecule activity,"Pf00038, Pf00063, Pf01442, Pf01576, Pf02463, Pf02736, Pf04111, Pf04156, Pf05622, Pf06160, Pf07888, Pf09311, Pf09726, Pf09731, Pf10079, Pf12128, Pf12252, Pf12325, Pf13166",4629,ENSG00000133392.17; ENSG00000276480.5,MYH11,16; CHR_HSCHR16_1_CTG1,Vascular smooth muscle contraction; Tight junction,,RHO GTPases activate PAKs; EPHA-mediated growth cone collapse; RHO GTPases Activate ROCKs; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate CIT; RHO GTPases activate PKNs,18,High,1
P12814-3,Isoform 3 of Alpha-actinin-1 OS=Homo sapiens OX=9606 GN=ACTN1,0,1151.82,69,95,6280,43,914,105.5,5.41,3300852,131.4,90,21,cell differentiation;cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytosol;extracellular;membrane;organelle lumen,metal ion binding;protein binding;RNA binding,"Pf00036, Pf00307, Pf00435, Pf08726, Pf11971, Pf13405, Pf13833",87,ENSG00000072110.13,ACTN1,14,,Arrhythmogenic Right Ventricular Cardiomyopathy; Focal Adhesion; Regulation of Actin Cytoskeleton,,3,High,1
P35749-2,Isoform 2 of Myosin-11 OS=Homo sapiens OX=9606 GN=MYH11,0,1142.997,51,115,2180,1,1979,227.9,5.5,987880,209.6,111,16,cell organization and biogenesis;metabolic process;transport,cytoskeleton;cytosol;extracellular,catalytic activity;motor activity;nucleotide binding;protein binding;structural molecule activity,"Pf00038, Pf00063, Pf01442, Pf01576, Pf02463, Pf02736, Pf04111, Pf04156, Pf05622, Pf06160, Pf07888, Pf09311, Pf09726, Pf09731, Pf10079, Pf12128, Pf12252, Pf12325, Pf13166",4629,ENSG00000133392.17; ENSG00000276480.5,MYH11,16; CHR_HSCHR16_1_CTG1,,,,0,High,1
P18206,Vinculin OS=Homo sapiens OX=9606 GN=VCL PE=1 SV=4,0,1138.983,67,95,4810,95,1134,123.7,5.66,2363271,21.42,93,20,cell growth;cell organization and biogenesis;cellular component movement;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;extracellular;membrane;organelle lumen,protein binding;structural molecule activity,Pf01044,7414,ENSG00000035403.17,VCL,10,Leukocyte transendothelial migration; Focal adhesion; Bacterial invasion of epithelial cells; Adherens junction; Shigellosis; Regulation of actin cytoskeleton; Amoebiasis,Integrin-mediated Cell Adhesion; Primary Focal Segmental Glomerulosclerosis FSGS; Focal Adhesion; VEGFA-VEGFR2 Signaling Pathway; Regulation of Actin Cytoskeleton,Signaling by BRAF and RAF fusions; MAP2K and MAPK activation; Smooth Muscle Contraction; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; Platelet degranulation ; Paradoxical activation of RAF signaling by kinase inactive BRAF; Neutrophil degranulation; Interleukin-20 family signaling,37,High,1
P00505,"Aspartate aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=GOT2 PE=1 SV=3",0,1138.331,85,85,8301,8,430,47.5,9.01,4084033,728.77,74,24,metabolic process;response to stimulus;transport,cell surface;membrane;mitochondrion;organelle lumen,catalytic activity;protein binding;RNA binding,Pf00155,2806,ENSG00000125166.12,GOT2,16,"Arginine and proline metabolism; Phenylalanine metabolism; Arginine biosynthesis; Metabolic pathways; Carbon metabolism; Fat digestion and absorption; Biosynthesis of amino acids; Alanine, aspartate and glutamate metabolism; Tyrosine metabolism; Cysteine and methionine metabolism; Phenylalanine, tyrosine and tryptophan biosynthesis; 2-Oxocarboxylic acid metabolism",Alanine and aspartate metabolism; Amino Acid metabolism; Glycolysis and Gluconeogenesis,Gluconeogenesis; Amino acid synthesis and interconversion (transamination); Glyoxylate metabolism and glycine degradation,22,High,1
Q13423,"NAD(P) transhydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=NNT PE=1 SV=3",0,1132.208,48,83,10717,83,1086,113.8,8.09,5103821,294.58,81,21,metabolic process;transport,membrane;mitochondrion,catalytic activity;nucleotide binding;transporter activity,"Pf01262, Pf02233, Pf05222, Pf12769",23530,ENSG00000112992.16,NNT,5,Nicotinate and nicotinamide metabolism; Metabolic pathways,,Citric acid cycle (TCA cycle),6,High,1
P00505-2,"Isoform 2 of Aspartate aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=GOT2",0,1090.533,84,78,7987,1,387,43,9.29,3951744,697.81,68,22,metabolic process;response to stimulus;transport,cell surface;membrane;mitochondrion;organelle lumen,catalytic activity;protein binding;RNA binding,Pf00155,2806,ENSG00000125166.12,GOT2,16,,Alanine and aspartate metabolism; Amino Acid metabolism; Glycolysis and Gluconeogenesis,,3,High,1
P02768,Serum albumin OS=Homo sapiens OX=9606 GN=ALB PE=1 SV=2,0,1084.782,65,107,14617,107,609,69.3,6.28,7414440,1063.15,99,23,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;extracellular;Golgi;nucleus;organelle lumen,antioxidant activity;catalytic activity;DNA binding;metal ion binding;protein binding,Pf00273,213,ENSG00000163631.16,ALB,4,Thyroid hormone synthesis,Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism,"Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Scavenging of heme from plasma; Platelet degranulation ; Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR); HDL remodeling; Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR); Transport of organic anions; Recycling of bile acids and salts",32,High,1
P22695,"Cytochrome b-c1 complex subunit 2, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRC2 PE=1 SV=3",0,1059.263,83,86,5113,86,453,48.4,8.63,2553123,111.59,84,9,metabolic process;transport,membrane;mitochondrion,catalytic activity;metal ion binding;protein binding,"Pf00675, Pf05193",7385,ENSG00000140740.10; ENSG00000284493.1,UQCRC2,16; CHR_HG926_PATCH,Parkinson's disease; Non-alcoholic fatty liver disease (NAFLD); Cardiac muscle contraction; Alzheimer's disease; Huntington's disease; Metabolic pathways; Oxidative phosphorylation,Electron Transport Chain,Respiratory electron transport,12,High,1
Q02218,"2-oxoglutarate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=OGDH PE=1 SV=3",0,1039.582,60,80,3859,59,1023,115.9,6.86,1921705,430.53,73,21,cellular component movement;metabolic process,cytosol;membrane;mitochondrion;organelle lumen,catalytic activity;metal ion binding;protein binding,"Pf00676, Pf02779",4967,ENSG00000105953.14,OGDH,7,Carbon metabolism; Metabolic pathways; Tryptophan metabolism; Lysine degradation; Citrate cycle (TCA cycle),TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc); Amino Acid metabolism; Tryptophan metabolism; TCA Cycle,Lysine catabolism; Glyoxylate metabolism and glycine degradation; Citric acid cycle (TCA cycle),17,High,1
Q9UKX3,Myosin-13 OS=Homo sapiens OX=9606 GN=MYH13 PE=2 SV=2,0,1039.544,20,93,24004,5,1938,223.5,5.68,11746083,953.31,84,30,metabolic process;regulation of biological process,cytoplasm,catalytic activity;motor activity;nucleotide binding;protein binding,"Pf00063, Pf01576, Pf02463, Pf02736, Pf04111, Pf04156, Pf05557, Pf05622, Pf05701, Pf07888, Pf08317, Pf09726, Pf10174, Pf12128, Pf13514",8735,ENSG00000006788.13,MYH13,17,Tight junction,,Translocation of GLUT4 to the plasma membrane,4,High,1
P40939,"Trifunctional enzyme subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=HADHA PE=1 SV=2",0,1036.826,66,75,9288,75,763,82.9,9.04,4442953,392.01,70,24,metabolic process;response to stimulus,membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding,"Pf00378, Pf00725, Pf02737",3030,ENSG00000084754.10,HADHA,2,"beta-Alanine metabolism; Propanoate metabolism; Valine, leucine and isoleucine degradation; Biosynthesis of unsaturated fatty acids; Lysine degradation; Fatty acid degradation; Fatty acid metabolism; Metabolic pathways; Tryptophan metabolism; Fatty acid elongation; Carbon metabolism; Butanoate metabolism",Fatty Acid Beta Oxidation; Mitochondrial LC-Fatty Acid Beta-Oxidation; Valproic acid pathway; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA; Beta oxidation of palmitoyl-CoA to myristoyl-CoA; Beta oxidation of myristoyl-CoA to lauroyl-CoA; Acyl chain remodeling of CL; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of octanoyl-CoA to hexanoyl-CoA,31,High,1
P31930,"Cytochrome b-c1 complex subunit 1, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRC1 PE=1 SV=3",0,992.471,73,77,6167,76,480,52.6,6.37,2791642,668.29,71,15,metabolic process;response to stimulus;transport,cytosol;membrane;mitochondrion,catalytic activity;metal ion binding;protein binding;transporter activity,"Pf00675, Pf05193, Pf08367",7384,ENSG00000010256.10,UQCRC1,3,Oxidative phosphorylation; Cardiac muscle contraction; Parkinson's disease; Non-alcoholic fatty liver disease (NAFLD); Alzheimer's disease; Huntington's disease; Metabolic pathways,Electron Transport Chain,Respiratory electron transport,12,High,1
P0C0L5,Complement C4-B OS=Homo sapiens OX=9606 GN=C4B PE=1 SV=2,0,986.882,51,84,2220,4,1744,192.6,7.27,1135939,14.7,83,10,defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,catalytic activity;enzyme regulator activity;protein binding,"Pf00207, Pf01759, Pf01821, Pf01835, Pf07677, Pf07678, Pf07703, Pf10569, Pf11974, Pf13249",721; 100293534,ENSG00000224389.8; ENSG00000228267.8,C4B; C4B_2; LOC100293534,6; CHR_HSCHR6_MHC_COX_CTG1,Staphylococcus aureus infection; Pertussis; Systemic lupus erythematosus; Complement and coagulation cascades,Allograft Rejection; Oxidative Damage; Complement Activation; Complement and Coagulation Cascades; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,Initial triggering of complement; Regulation of Complement cascade; Activation of C3 and C5,15,High,1
O75112-7,Isoform 7 of LIM domain-binding protein 3 OS=Homo sapiens OX=9606 GN=LDB3,0,985.391,65,64,6293,1,732,78.5,8.15,2753610,1743.86,55,22,cell organization and biogenesis,cytoskeleton,metal ion binding;protein binding,"Pf00412, Pf00595",11155,ENSG00000122367.19,LDB3,10,,,,0,High,1
P49748,"Very long-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADVL PE=1 SV=1",0,984.002,76,83,8892,83,655,70.3,8.75,4336748,201.81,77,23,cell differentiation;metabolic process;regulation of biological process;response to stimulus,cytosol;membrane;mitochondrion;nucleus;organelle lumen,catalytic activity;nucleotide binding,"Pf00441, Pf02770, Pf02771, Pf08028",37,ENSG00000072778.19,ACADVL,17,Fatty acid degradation; Fatty acid metabolism; Metabolic pathways,Fatty Acid Beta Oxidation; Mitochondrial LC-Fatty Acid Beta-Oxidation,Beta oxidation of palmitoyl-CoA to myristoyl-CoA; XBP1(S) activates chaperone genes,15,High,1
P22105-1,Isoform 3 of Tenascin-X OS=Homo sapiens OX=9606 GN=TNXB,0,983.958,37,115,1489,115,4242,457.9,5.17,697349,9.56,115,8,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,catalytic activity;nucleotide binding;protein binding;receptor activity;signal transducer activity,"Pf00041, Pf00147, Pf00757, Pf01500, Pf04885, Pf07974",7148,,TNXB,6,PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; MicroRNAs in cancer,miRNA targets in ECM and membrane receptors; Focal Adhesion; VEGFA-VEGFR2 Signaling Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,ECM proteoglycans,10,High,1
P10809,"60 kDa heat shock protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPD1 PE=1 SV=2",0,973.72,79,75,4518,75,573,61,5.87,2119058,86.9,72,22,cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;cytosol;endosome;membrane;mitochondrion;organelle lumen,catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding,Pf00118,3329,ENSG00000144381.16,HSPD1,2,RNA degradation; Tuberculosis; Legionellosis; Type I diabetes mellitus,Apoptosis-related network due to altered Notch3 in ovarian cancer; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation; Mitochondrial protein import; Metabolism of proteins,13,High,1
P04075,Fructose-bisphosphate aldolase A OS=Homo sapiens OX=9606 GN=ALDOA PE=1 SV=2,0,970.102,85,69,5553,53,364,39.4,8.09,2710026,659.7,63,12,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen,catalytic activity;protein binding;RNA binding,Pf00274,226,ENSG00000149925.17,ALDOA,16,Carbon metabolism; Metabolic pathways; Pentose phosphate pathway; HIF-1 signaling pathway; Glycolysis / Gluconeogenesis; Biosynthesis of amino acids; Fructose and mannose metabolism,Glycolysis and Gluconeogenesis; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,Platelet degranulation ; Gluconeogenesis; Glycolysis; Neutrophil degranulation,21,High,1
Q9Y4G6,Talin-2 OS=Homo sapiens OX=9606 GN=TLN2 PE=1 SV=4,0,968.747,44,89,1779,80,2542,271.4,5.57,827317,78.75,85,17,cell organization and biogenesis,cytoplasm;cytoskeleton;membrane,protein binding;structural molecule activity,"Pf00373, Pf01608, Pf02174, Pf08913, Pf09141, Pf09379",83660,ENSG00000171914.16,TLN2,15,Platelet activation; HTLV-I infection; Focal adhesion; Rap1 signaling pathway,,,4,High,1
P0C0L4,Complement C4-A OS=Homo sapiens OX=9606 GN=C4A PE=1 SV=2,0,968.083,50,84,2245,4,1744,192.7,7.08,1151293,14.7,83,10,defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane;organelle lumen,catalytic activity;enzyme regulator activity;protein binding,"Pf00207, Pf01759, Pf01821, Pf01835, Pf07677, Pf07678, Pf07703, Pf10569, Pf11974, Pf13249",720; 721,ENSG00000244731.7,C4A; C4B,6,Systemic lupus erythematosus; Staphylococcus aureus infection; Pertussis; Complement and coagulation cascades,Allograft Rejection; Complement Activation; Complement and Coagulation Cascades; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Initial triggering of complement; Regulation of Complement cascade; Activation of C3 and C5,18,High,1
Q00610,Clathrin heavy chain 1 OS=Homo sapiens OX=9606 GN=CLTC PE=1 SV=5,0,961.039,55,82,2263,61,1675,191.5,5.69,1084678,60.77,77,15,cell differentiation;cell division;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endosome;membrane;vacuole,protein binding;RNA binding;structural molecule activity,"Pf00637, Pf01394, Pf04053, Pf09268, Pf13838",1213,ENSG00000141367.11,CLTC,17,Endocrine and other factor-regulated calcium reabsorption; Synaptic vesicle cycle; Endocytosis; Bacterial invasion of epithelial cells; Huntington's disease; Lysosome,Synaptic Vesicle Pathway; VEGFA-VEGFR2 Signaling Pathway; Complement and Coagulation Cascades,"Cargo recognition for clathrin-mediated endocytosis; Formation of annular gap junctions; Golgi Associated Vesicle Biogenesis; Recycling pathway of L1; LDL clearance; Lysosome Vesicle Biogenesis; EPH-ephrin mediated repulsion of cells; Entry of Influenza Virion into Host Cell via Endocytosis; Retrograde neurotrophin signalling; VLDLR internalisation and degradation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; MHC class II antigen presentation; WNT5A-dependent internalization of FZD4",50,High,1
P06744,Glucose-6-phosphate isomerase OS=Homo sapiens OX=9606 GN=GPI PE=1 SV=4,0,954.298,72,70,4720,70,558,63.1,8.32,2291368,127.92,68,13,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;membrane;organelle lumen,catalytic activity;protein binding,Pf00342,2821,ENSG00000105220.14,GPI,19,Glycolysis / Gluconeogenesis; Metabolic pathways; Starch and sucrose metabolism; Amino sugar and nucleotide sugar metabolism; Pentose phosphate pathway; Carbon metabolism,Cori Cycle; Glycolysis and Gluconeogenesis,Glycolysis; Neutrophil degranulation; Gluconeogenesis; TP53 Regulates Metabolic Genes,21,High,1
O76041,Nebulette OS=Homo sapiens OX=9606 GN=NEBL PE=1 SV=1,0,953.01,60,58,3747,51,1014,116.4,7.99,1732673,1105.29,49,27,cell organization and biogenesis,cytoplasm,protein binding;structural molecule activity,"Pf00018, Pf00880, Pf07653, Pf14604",10529,ENSG00000078114.18,NEBL,10,,,,0,High,1
O43707,Alpha-actinin-4 OS=Homo sapiens OX=9606 GN=ACTN4 PE=1 SV=2,0,950.201,67,82,4971,37,911,104.8,5.44,2445523,101.19,79,17,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;extracellular;nucleus;organelle lumen,DNA binding;metal ion binding;protein binding;RNA binding,"Pf00307, Pf00435, Pf08726, Pf11971, Pf13499",81,ENSG00000282844.1; ENSG00000130402.11,ACTN4,19; CHR_HG26_PATCH,Regulation of actin cytoskeleton; Tight junction; Viral carcinogenesis; Leukocyte transendothelial migration; Focal adhesion; Amoebiasis; Systemic lupus erythematosus; Adherens junction; Arrhythmogenic right ventricular cardiomyopathy (ARVC),Arrhythmogenic Right Ventricular Cardiomyopathy; Primary Focal Segmental Glomerulosclerosis FSGS; Striated Muscle Contraction,Platelet degranulation ; Nephrin family interactions,18,High,1
P16615,Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 OS=Homo sapiens OX=9606 GN=ATP2A2 PE=1 SV=1,0,946.405,48,68,4989,60,1042,114.7,5.34,2397509,330.19,60,24,cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding;transporter activity,"Pf00122, Pf00689, Pf00690, Pf00702, Pf08282, Pf12710, Pf13246",488,ENSG00000174437.16,ATP2A2,12,Pancreatic secretion; cGMP-PKG signaling pathway; Calcium signaling pathway; Alzheimer's disease; Thyroid hormone signaling pathway; Arrhythmogenic right ventricular cardiomyopathy (ARVC); cAMP signaling pathway; Hypertrophic cardiomyopathy (HCM); Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; Dilated cardiomyopathy,Alzheimers Disease; Arrhythmogenic Right Ventricular Cardiomyopathy; Endothelin Pathways; Myometrial Relaxation and Contraction Pathways; Calcium Regulation in the Cardiac Cell,Ion homeostasis; Pre-NOTCH Processing in Golgi; Ion transport by P-type ATPases; Reduction of cytosolic Ca++ levels,30,High,1
P06732,Creatine kinase M-type OS=Homo sapiens OX=9606 GN=CKM PE=1 SV=2,0,939.739,80,71,13329,42,381,43.1,7.25,6491509,920.8,67,19,metabolic process,cytoplasm;cytosol,catalytic activity;nucleotide binding;protein binding,"Pf00217, Pf02807",1158,ENSG00000104879.4,CKM,19,Arginine and proline metabolism; Metabolic pathways,Urea cycle and metabolism of amino groups,Creatine metabolism,7,High,1
P14618,Pyruvate kinase PKM OS=Homo sapiens OX=9606 GN=PKM PE=1 SV=4,0,924.286,77,72,3810,7,531,57.9,7.84,1852152,650.19,67,16,cell death;cell organization and biogenesis;metabolic process;response to stimulus;transport,cytoplasm;cytosol;extracellular;mitochondrion;nucleus;organelle lumen,catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding,"Pf00224, Pf02887",5315,ENSG00000067225.17,PKM,15,Carbon metabolism; Glycolysis / Gluconeogenesis; Pyruvate metabolism; Central carbon metabolism in cancer; Metabolic pathways; Glucagon signaling pathway; Purine metabolism; Viral carcinogenesis; Biosynthesis of amino acids; Type II diabetes mellitus,Photodynamic therapy-induced HIF-1 survival signaling; Amino Acid metabolism; Glycolysis and Gluconeogenesis,Glycolysis; Neutrophil degranulation,20,High,1
P42704,"Leucine-rich PPR motif-containing protein, mitochondrial OS=Homo sapiens OX=9606 GN=LRPPRC PE=1 SV=3",0,921.822,59,88,2413,87,1394,157.8,6.13,1177405,9.77,86,15,cellular component movement;metabolic process;regulation of biological process;transport,chromosome;cytoplasm;cytoskeleton;membrane;mitochondrion;nucleus,catalytic activity;DNA binding;protein binding;RNA binding,"Pf12854, Pf13041, Pf13812",10128,ENSG00000138095.18,LRPPRC,2,,,TP53 Regulates Metabolic Genes; Respiratory electron transport,9,High,1
Q9HBL0,Tensin-1 OS=Homo sapiens OX=9606 GN=TNS1 PE=1 SV=2,0,921.5,63,79,1669,60,1735,185.6,7.75,801061,78.13,74,15,cell organization and biogenesis;cellular component movement,cell surface;cytoplasm;cytoskeleton,protein binding;RNA binding,"Pf00017, Pf08416, Pf10409",7145,ENSG00000079308.16,TNS1,2,,Integrin-mediated Cell Adhesion,,1,High,1
P55084,"Trifunctional enzyme subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=HADHB PE=1 SV=3",0,917.264,73,73,7431,73,474,51.3,9.41,3650619,90.17,71,15,metabolic process,endoplasmic reticulum;membrane;mitochondrion,catalytic activity;protein binding;RNA binding,"Pf00108, Pf00109, Pf02803",3032,ENSG00000138029.13,HADHB,2,"Fatty acid metabolism; Metabolic pathways; Fatty acid degradation; Valine, leucine and isoleucine degradation; Fatty acid elongation",Fatty Acid Beta Oxidation; Valproic acid pathway; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA; Beta oxidation of palmitoyl-CoA to myristoyl-CoA; Beta oxidation of myristoyl-CoA to lauroyl-CoA; Acyl chain remodeling of CL; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of octanoyl-CoA to hexanoyl-CoA,23,High,1
O75369,Filamin-B OS=Homo sapiens OX=9606 GN=FLNB PE=1 SV=2,0,916.975,48,112,3033,83,2602,278,5.73,1501373,86.54,109,11,cell differentiation;cell organization and biogenesis;development;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,protein binding;RNA binding,"Pf00307, Pf00630",2317,ENSG00000136068.14,FLNB,3,Salmonella infection; Focal adhesion; Proteoglycans in cancer; MAPK signaling pathway,VEGFA-VEGFR2 Signaling Pathway,ISG15 antiviral mechanism,10,High,1
P04114,Apolipoprotein B-100 OS=Homo sapiens OX=9606 GN=APOB PE=1 SV=2,0,914.99,41,144,945,144,4563,515.3,7.05,398341,0,144,9,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;endosome;extracellular;membrane;organelle lumen,protein binding;transporter activity,"Pf01347, Pf04286, Pf06448, Pf09172, Pf12491",338,,APOB,2,Fat digestion and absorption; Vitamin digestion and absorption,Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism; Statin Pathway,Post-translational protein phosphorylation; Cargo recognition for clathrin-mediated endocytosis; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); LDL remodeling; Scavenging by Class H Receptors; VLDL clearance; Retinoid metabolism and transport; Chylomicron remodeling; Scavenging by Class A Receptors; LDL clearance; Platelet sensitization by LDL; Signaling by GPCR; Scavenging by Class B Receptors; Scavenging by Class F Receptors; VLDL assembly; Chylomicron assembly; Regulation of TLR by endogenous ligand; Cell surface interactions at the vascular wall; Chylomicron clearance,46,High,1
O15061,Synemin OS=Homo sapiens OX=9606 GN=SYNM PE=1 SV=2,0,909.985,51,79,1750,6,1565,172.7,5.16,862670,42.87,78,11,cell organization and biogenesis,cytoplasm;cytoskeleton;membrane,protein binding;structural molecule activity,Pf00038,23336,,SYNM,15,,,,0,High,1
P14618-2,Isoform M1 of Pyruvate kinase PKM OS=Homo sapiens OX=9606 GN=PKM,0,894.761,78,68,3788,3,531,58,7.71,1712737,1439.1,60,19,cell death;cell organization and biogenesis;metabolic process;response to stimulus;transport,cytoplasm;cytosol;extracellular;mitochondrion;nucleus;organelle lumen,catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding,"Pf00224, Pf02887",5315,ENSG00000067225.17,PKM,15,,Photodynamic therapy-induced HIF-1 survival signaling; Amino Acid metabolism; Glycolysis and Gluconeogenesis,Glycolysis,7,High,1
P68871,Hemoglobin subunit beta OS=Homo sapiens OX=9606 GN=HBB PE=1 SV=2,0,887.64,97,79,25196,39,147,16,7.28,14010385,598.18,77,12,cell organization and biogenesis;coagulation;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;extracellular;organelle lumen,antioxidant activity;catalytic activity;metal ion binding;protein binding;transporter activity,Pf00042,3043,ENSG00000244734.3,HBB,11,African trypanosomiasis; Malaria,Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism,Neutrophil degranulation; Scavenging of heme from plasma; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide; Factors involved in megakaryocyte development and platelet production,17,High,1
Q16891-3,Isoform 3 of MICOS complex subunit MIC60 OS=Homo sapiens OX=9606 GN=IMMT,0,879.551,70,74,4114,1,726,80,6.74,1920729,605.4,72,12,cell organization and biogenesis;cellular homeostasis,membrane;mitochondrion,protein binding;RNA binding,"Pf07227, Pf09731",10989,,IMMT,2,,,,0,High,1
P01023,Alpha-2-macroglobulin OS=Homo sapiens OX=9606 GN=A2M PE=1 SV=3,0,876.22,49,80,2649,80,1474,163.2,6.46,1287032,90.76,77,10,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;extracellular;organelle lumen,enzyme regulator activity;protein binding,"Pf00207, Pf01835, Pf07677, Pf07678, Pf07703, Pf10569, Pf11974, Pf13249",2,ENSG00000175899.14,A2M,12,Complement and coagulation cascades,Complement and Coagulation Cascades,Platelet degranulation ; Degradation of the extracellular matrix; Rho GTPase cycle; HDL assembly; Intrinsic Pathway of Fibrin Clot Formation,17,High,1
O15061-2,Isoform 2 of Synemin OS=Homo sapiens OX=9606 GN=SYNM,0,874.176,59,74,1692,1,1253,140.1,5.07,831489,74.01,72,12,cell organization and biogenesis,cytoskeleton;membrane,protein binding;structural molecule activity,Pf00038,23336,,SYNM,15,,,,0,High,1
Q16891-2,Isoform 2 of MICOS complex subunit MIC60 OS=Homo sapiens OX=9606 GN=IMMT,0,873.268,67,74,3936,2,747,82.6,6.57,1899979,137,72,12,cell organization and biogenesis;cellular homeostasis,membrane;mitochondrion,protein binding;RNA binding,"Pf07227, Pf09731",10989,ENSG00000132305.20,IMMT,2,,,,0,High,1
P12277,Creatine kinase B-type OS=Homo sapiens OX=9606 GN=CKB PE=1 SV=1,0,871.006,87,70,5253,39,381,42.6,5.59,2442386,48.06,68,6,cellular homeostasis;metabolic process,cytoplasm;cytosol;mitochondrion;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00217, Pf02807",1152,ENSG00000166165.12,CKB,14,Metabolic pathways; Arginine and proline metabolism,Urea cycle and metabolism of amino groups,Creatine metabolism,7,High,1
Q5VTT5,Myomesin-3 OS=Homo sapiens OX=9606 GN=MYOM3 PE=1 SV=1,0,859.528,53,66,3270,66,1437,162.1,6.23,1451182,1242.53,50,42,cell organization and biogenesis,cytoplasm,protein binding;structural molecule activity,"Pf00041, Pf00047, Pf07679, Pf13895, Pf13927",127294,ENSG00000142661.18,MYOM3,1,,,,0,High,1
Q16891-4,Isoform 4 of MICOS complex subunit MIC60 OS=Homo sapiens OX=9606 GN=IMMT,0,857.858,67,74,3962,1,757,83.5,6.57,1920729,30.43,72,12,cell organization and biogenesis;cellular homeostasis,membrane;mitochondrion,protein binding;RNA binding,Pf09731,10989,ENSG00000132305.20,IMMT,2,,,,0,High,1
P08670,Vimentin OS=Homo sapiens OX=9606 GN=VIM PE=1 SV=4,0,856.234,84,80,6871,66,466,53.6,5.12,3478072,17.46,79,16,cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane,protein binding;RNA binding;structural molecule activity,"Pf00038, Pf04111, Pf04156, Pf04732, Pf05622, Pf10186",7431,ENSG00000026025.15,VIM,10,Epstein-Barr virus infection; MicroRNAs in cancer,Allograft Rejection; Spinal Cord Injury; Primary Focal Segmental Glomerulosclerosis FSGS; Apoptosis-related network due to altered Notch3 in ovarian cancer; Striated Muscle Contraction; TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition; T-Cell antigen Receptor (TCR)  Signaling Pathway,Interleukin-4 and 13 signaling; Caspase-mediated cleavage of cytoskeletal proteins; Striated Muscle Contraction,20,High,1
Q9BX66-11,Isoform 11 of Sorbin and SH3 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SORBS1,0,852.308,57,72,3030,8,1266,139.3,7.42,1456214,122.8,66,18,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytosol;membrane;nucleus,protein binding,"Pf00018, Pf02208, Pf07653, Pf14604",10580,ENSG00000095637.21,SORBS1,10,,Integrin-mediated Cell Adhesion; PPAR signaling pathway; Insulin Signaling,,3,High,1
P04264,"Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6",0,846.578,65,78,3604,67,644,66,8.12,1852152,124.25,78,15,cell death;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoskeleton;cytosol;extracellular;membrane;nucleus,catalytic activity;motor activity;protein binding;receptor activity;structural molecule activity,"Pf00038, Pf01576, Pf05103, Pf05957, Pf12128, Pf13166, Pf13514",3848,ENSG00000167768.4,KRT1,12,,Corticotropin-releasing hormone signaling pathway,Formation of the cornified envelope; Neutrophil degranulation,7,High,1
O75923,Dysferlin OS=Homo sapiens OX=9606 GN=DYSF PE=1 SV=1,0,829.688,45,81,1755,77,2080,237.1,5.64,820107,30.43,77,8,cell organization and biogenesis,endosome;membrane,metal ion binding;protein binding,"Pf00168, Pf06398, Pf08150, Pf08151, Pf08165",8291,ENSG00000135636.13,DYSF,2,,,Smooth Muscle Contraction,2,High,1
P35908,"Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2",0,816.95,82,72,2292,56,639,65.4,8,1118630,13.62,72,8,cell death;cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process,cytoskeleton;cytosol;membrane;nucleus,protein binding;structural molecule activity,"Pf00038, Pf08614, Pf12128, Pf13166",3849,ENSG00000172867.3,KRT2,12,,,Formation of the cornified envelope,3,High,1
Q9UPN3,"Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 OS=Homo sapiens OX=9606 GN=MACF1 PE=1 SV=4",0,813.243,26,152,624,34,7388,837.8,5.39,268814,2.57,151,2,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;Golgi;membrane,catalytic activity;metal ion binding;motor activity;protein binding;RNA binding,"Pf00036, Pf00307, Pf00435, Pf00681, Pf01576, Pf02187, Pf10498, Pf11971, Pf13499, Pf13514, Pf13833",23499,ENSG00000127603.23,MACF1,1,,Mesodermal Commitment Pathway,Signaling by BRAF and RAF fusions,5,High,1
P11216,"Glycogen phosphorylase, brain form OS=Homo sapiens OX=9606 GN=PYGB PE=1 SV=5",0,813.164,60,70,3483,53,843,96.6,6.86,1757144,79.32,64,17,metabolic process;transport,cytoplasm;extracellular;membrane;organelle lumen,catalytic activity;protein binding,Pf00343,5834,ENSG00000100994.11,PYGB,20,Glucagon signaling pathway; Metabolic pathways; Insulin resistance; Starch and sucrose metabolism; Insulin signaling pathway,Glycogen Metabolism,Neutrophil degranulation; Glycogen breakdown (glycogenolysis),13,High,1
P02751-1,Isoform 1 of Fibronectin OS=Homo sapiens OX=9606 GN=FN1,0,811.383,39,73,1360,73,2386,262.5,5.71,679860,8.32,73,5,cell differentiation;cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane;organelle lumen,enzyme regulator activity;protein binding,"Pf00039, Pf00040, Pf00041",2335,ENSG00000115414.18,FN1,2,AGE-RAGE signaling pathway in diabetic complications; Small cell lung cancer; Focal adhesion; ECM-receptor interaction; Proteoglycans in cancer; PI3K-Akt signaling pathway; Amoebiasis; Regulation of actin cytoskeleton; Pathways in cancer; Bacterial invasion of epithelial cells,miRNA targets in ECM and membrane receptors; Focal Adhesion; Overview of nanoparticle effects; Rac1/Pak1/p38/MMP-2 pathway; TGF-beta Signaling Pathway; Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway; Association Between Physico-Chemical Features and Toxicity Associated Pathways; TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; miR-509-3p alteration of YAP1/ECM axis; Inflammatory Response Pathway; Regulation of Actin Cytoskeleton; Senescence and Autophagy in Cancer,Post-translational protein phosphorylation; Integrin cell surface interactions; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Signaling by BRAF and RAF fusions; MET activates PTK2 signaling; MAP2K and MAPK activation; Molecules associated with elastic fibres; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Syndecan interactions; Signaling by moderate kinase activity BRAF mutants; p130Cas linkage to MAPK signaling for integrins; Platelet degranulation ; ECM proteoglycans; Paradoxical activation of RAF signaling by kinase inactive BRAF; Degradation of the extracellular matrix; Cell surface interactions at the vascular wall; Interleukin-4 and 13 signaling; Fibronectin matrix formation; Interleukin-20 family signaling,68,High,1
P48735,"Isocitrate dehydrogenase [NADP], mitochondrial OS=Homo sapiens OX=9606 GN=IDH2 PE=1 SV=2",0,802.88,77,75,12863,64,452,50.9,8.69,6474177,209.1,67,19,cell organization and biogenesis;metabolic process;regulation of biological process,cytosol;membrane;mitochondrion;organelle lumen,catalytic activity;metal ion binding;nucleotide binding,Pf00180,3418,ENSG00000182054.9,IDH2,15,Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; Peroxisome; 2-Oxocarboxylic acid metabolism; Glutathione metabolism; Citrate cycle (TCA cycle),TCA Cycle,Transcriptional activation of mitochondrial biogenesis; Citric acid cycle (TCA cycle),15,High,1
P68371,Tubulin beta-4B chain OS=Homo sapiens OX=9606 GN=TUBB4B PE=1 SV=1,0,801.647,71,65,5020,1,445,49.8,4.89,2502999,122.57,64,13,cell organization and biogenesis;cellular component movement;defense response;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;extracellular;nucleus;organelle lumen,catalytic activity;nucleotide binding;protein binding;RNA binding;structural molecule activity,"Pf00091, Pf03953, Pf10644",10383,ENSG00000188229.5,TUBB4B,9,Pathogenic Escherichia coli infection; Gap junction; Phagosome,Pathogenic Escherichia coli infection; Parkin-Ubiquitin Proteasomal System pathway,COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Loss of Nlp from mitotic centrosomes; Translocation of GLUT4 to the plasma membrane; Prefoldin mediated transfer of substrate  to CCT/TriC; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Neutrophil degranulation; Separation of Sister Chromatids; COPI-mediated anterograde transport; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR); Kinesins; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recruitment of mitotic centrosome proteins and complexes; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; Post-chaperonin tubulin folding pathway; RHO GTPases Activate Formins; MHC class II antigen presentation,74,High,1
P31040,"Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Homo sapiens OX=9606 GN=SDHA PE=1 SV=2",0,801.472,57,61,4039,61,664,72.6,7.39,1986426,310.77,57,12,metabolic process;transport,membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding,"Pf00890, Pf02910",6389,ENSG00000073578.16,SDHA,5,Oxidative phosphorylation; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Parkinson's disease; Citrate cycle (TCA cycle); Metabolic pathways; Alzheimer's disease; Carbon metabolism,Electron Transport Chain; TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc); Amino Acid metabolism; TCA Cycle,Respiratory electron transport; Citric acid cycle (TCA cycle),18,High,1
P07437,Tubulin beta chain OS=Homo sapiens OX=9606 GN=TUBB PE=1 SV=2,0,791.443,71,63,4826,8,444,49.6,4.89,2399053,128.03,62,13,cell division;cell organization and biogenesis;cellular component movement;defense response;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;extracellular;membrane;nucleus;organelle lumen,catalytic activity;nucleotide binding;protein binding;structural molecule activity,"Pf00091, Pf03953, Pf10644",203068,ENSG00000232575.10; ENSG00000196230.12; ENSG00000227739.10; ENSG00000224156.10; ENSG00000235067.10; ENSG00000229684.10; ENSG00000183311.16; ENSG00000232421.10,TUBB,6; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_APD_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1,Gap junction; Pathogenic Escherichia coli infection; Phagosome,Pathogenic Escherichia coli infection; Parkin-Ubiquitin Proteasomal System pathway,Neutrophil degranulation; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes,24,High,1
P28331,"NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS1 PE=1 SV=3",0,791.119,68,63,5788,63,727,79.4,6.23,2898592,186.81,58,20,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion;organelle lumen,catalytic activity;metal ion binding;protein binding,"Pf00111, Pf00384, Pf09326, Pf10588, Pf13510",4719,ENSG00000283447.1; ENSG00000023228.13,NDUFS1,2; CHR_HSCHR2_6_CTG7_2,Oxidative phosphorylation; Huntington's disease; Metabolic pathways; Alzheimer's disease; Non-alcoholic fatty liver disease (NAFLD); Parkinson's disease,Electron Transport Chain; Oxidative phosphorylation,Complex I biogenesis,13,High,1
P08590,Myosin light chain 3 OS=Homo sapiens OX=9606 GN=MYL3 PE=1 SV=3,0,789.811,86,59,19817,51,195,21.9,5.1,10053010,877.65,54,20,cellular component movement;regulation of biological process,cytosol,catalytic activity;metal ion binding;motor activity;protein binding;structural molecule activity,Pf13499,4634,ENSG00000160808.9,MYL3,3,Adrenergic signaling in cardiomyocytes; Hypertrophic cardiomyopathy (HCM); Dilated cardiomyopathy; Cardiac muscle contraction,Striated Muscle Contraction; Regulation of Actin Cytoskeleton,Striated Muscle Contraction,8,High,1
O75306,"NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS2 PE=1 SV=2",0,789.451,64,46,4020,46,463,52.5,7.55,1991148,87.67,46,7,cell organization and biogenesis;metabolic process;response to stimulus;transport,membrane;mitochondrion;organelle lumen,catalytic activity;metal ion binding;nucleotide binding;protein binding,Pf00346,4720,ENSG00000158864.12,NDUFS2,1,Oxidative phosphorylation; Metabolic pathways; Parkinson's disease; Non-alcoholic fatty liver disease (NAFLD); Alzheimer's disease; Huntington's disease,Electron Transport Chain; Oxidative phosphorylation,Complex I biogenesis,13,High,1
O94875-10,Isoform 10 of Sorbin and SH3 domain-containing protein 2 OS=Homo sapiens OX=9606 GN=SORBS2,0,788.42,69,55,3880,9,824,91.2,9.17,1544625,2263.04,44,25,cell growth;cell organization and biogenesis,cytoskeleton;membrane;nucleus,protein binding;RNA binding;structural molecule activity,"Pf00018, Pf02208, Pf07653, Pf14604",8470,ENSG00000154556.17,SORBS2,4,,,,0,High,1
P55072,Transitional endoplasmic reticulum ATPase OS=Homo sapiens OX=9606 GN=VCP PE=1 SV=4,0,785.262,64,65,1913,65,806,89.3,5.26,936311,81.61,59,11,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;extracellular;membrane;nucleus;organelle lumen;proteasome,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding;RNA binding,"Pf00004, Pf00910, Pf01057, Pf01078, Pf02359, Pf02933, Pf05496, Pf05673, Pf06068, Pf07724, Pf07726, Pf07728, Pf09336, Pf13191, Pf13207, Pf13401",7415,ENSG00000165280.15,VCP,9,Protein processing in endoplasmic reticulum; Legionellosis,,Protein methylation; Translesion Synthesis by POLH; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Josephin domain DUBs; Ovarian tumor domain proteases; ABC-family proteins mediated transport; HSF1 activation; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; E3 ubiquitin ligases ubiquitinate target proteins; Neutrophil degranulation; Defective CFTR causes cystic fibrosis; Hedgehog ligand biogenesis,35,High,1
P42765,"3-ketoacyl-CoA thiolase, mitochondrial OS=Homo sapiens OX=9606 GN=ACAA2 PE=1 SV=2",0,773.003,71,54,3980,54,397,41.9,8.09,2152476,85.45,53,5,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,membrane;mitochondrion;organelle lumen,catalytic activity;protein binding;RNA binding,"Pf00108, Pf02801, Pf02803",10449,ENSG00000167315.17,ACAA2,18,"Fatty acid elongation; Valine, leucine and isoleucine degradation; Fatty acid metabolism; Metabolic pathways; Fatty acid degradation",Fatty Acid Biosynthesis,Mitochondrial Fatty Acid Beta-Oxidation,10,High,1
P06396,Gelsolin OS=Homo sapiens OX=9606 GN=GSN PE=1 SV=1,0,770.579,59,53,2644,53,782,85.6,6.28,1355935,9.01,52,5,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen,metal ion binding;protein binding,Pf00626,2934,ENSG00000148180.19,GSN,9,Viral carcinogenesis; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton,Regulation of Actin Cytoskeleton; Senescence and Autophagy in Cancer,Neutrophil degranulation; Caspase-mediated cleavage of cytoskeletal proteins; Amyloid fiber formation,15,High,1
O75112-2,Isoform 2 of LIM domain-binding protein 3 OS=Homo sapiens OX=9606 GN=LDB3,0,766.828,62,46,5604,1,617,66.6,7.99,2408130,1731.08,38,17,cell organization and biogenesis,cytoskeleton,metal ion binding;protein binding,"Pf00412, Pf00595",11155,ENSG00000122367.19,LDB3,10,,,,0,High,1
Q7Z406,Myosin-14 OS=Homo sapiens OX=9606 GN=MYH14 PE=1 SV=2,0,763.222,49,93,1236,74,1995,227.7,5.6,544601,193.76,89,9,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;motor activity;nucleotide binding;protein binding,"Pf00063, Pf01576",79784,ENSG00000105357.15,MYH14,19,Tight junction; Regulation of actin cytoskeleton; Salmonella infection,,RHO GTPases activate PAKs; EPHA-mediated growth cone collapse; RHO GTPases Activate ROCKs; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate CIT; RHO GTPases activate PKNs,17,High,1
P35580,Myosin-10 OS=Homo sapiens OX=9606 GN=MYH10 PE=1 SV=3,0,760.65,48,94,1216,1,1976,228.9,5.54,518321,179.94,90,10,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;nucleus,catalytic activity;motor activity;nucleotide binding;protein binding;transporter activity,"Pf00063, Pf00769, Pf01496, Pf01576, Pf02736, Pf04111, Pf05622, Pf05911, Pf06637, Pf07888, Pf09726, Pf12128, Pf13094, Pf13514",4628,ENSG00000133026.12,MYH10,17,Regulation of actin cytoskeleton; Tight junction; Salmonella infection,Regulation of Actin Cytoskeleton,RHO GTPases activate PAKs; EPHA-mediated growth cone collapse; RHO GTPases Activate ROCKs; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate CIT; RHO GTPases activate PKNs,18,High,1
O75390,"Citrate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=CS PE=1 SV=2",0,759.308,68,57,6702,57,466,51.7,8.32,3307358,331.73,57,9,metabolic process,mitochondrion;nucleus;organelle lumen,catalytic activity;RNA binding,Pf00285,1431,ENSG00000062485.18,CS,12,2-Oxocarboxylic acid metabolism; Citrate cycle (TCA cycle); Glyoxylate and dicarboxylate metabolism; Biosynthesis of amino acids; Metabolic pathways; Carbon metabolism,TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc); Amino Acid metabolism; TCA Cycle,Mitochondrial protein import; Metabolism of proteins; Citric acid cycle (TCA cycle),15,High,1
P09622,"Dihydrolipoyl dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=DLD PE=1 SV=2",0,757.187,62,47,5854,47,509,54.1,7.85,2775019,221.07,45,11,cellular homeostasis;metabolic process;regulation of biological process,mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding,"Pf00070, Pf00890, Pf01134, Pf02852, Pf03486, Pf07992, Pf12831, Pf13450",1738,ENSG00000091140.13,DLD,7,"Valine, leucine and isoleucine degradation; Glycolysis / Gluconeogenesis; Carbon metabolism; Glyoxylate and dicarboxylate metabolism; Pyruvate metabolism; Citrate cycle (TCA cycle); Metabolic pathways; Glycine, serine and threonine metabolism; Propanoate metabolism",Fatty Acid Beta Oxidation; TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc); Amino Acid metabolism; Glycolysis and Gluconeogenesis; TCA Cycle,Glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Lysine catabolism; Signaling by Retinoic Acid; Branched-chain amino acid catabolism; Citric acid cycle (TCA cycle),29,High,1
P35580-4,Isoform 4 of Myosin-10 OS=Homo sapiens OX=9606 GN=MYH10,0,757.039,48,94,1212,1,2007,232.4,5.55,513729,199.18,89,11,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;nucleus,catalytic activity;motor activity;nucleotide binding;protein binding;transporter activity,"Pf00063, Pf00769, Pf01496, Pf01576, Pf02736, Pf04111, Pf05622, Pf05911, Pf06637, Pf07888, Pf09726, Pf12128, Pf13094, Pf13514",4628,ENSG00000133026.12,MYH10,17,,Regulation of Actin Cytoskeleton,,1,High,1
P02671,Fibrinogen alpha chain OS=Homo sapiens OX=9606 GN=FGA PE=1 SV=2,0,739.317,57,67,2512,67,866,94.9,6.01,1268751,103.52,64,11,cell organization and biogenesis;coagulation;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;extracellular;membrane;organelle lumen,metal ion binding;protein binding;structural molecule activity,"Pf00147, Pf02414, Pf08702, Pf12160",2243,ENSG00000171560.14,FGA,4,Complement and coagulation cascades; Platelet activation,Blood Clotting Cascade; VEGFA-VEGFR2 Signaling Pathway,Post-translational protein phosphorylation; Integrin cell surface interactions; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Signaling by BRAF and RAF fusions; Amyloid fiber formation; MAP2K and MAPK activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; p130Cas linkage to MAPK signaling for integrins; Platelet degranulation ; Paradoxical activation of RAF signaling by kinase inactive BRAF; Common Pathway of Fibrin Clot Formation; Regulation of TLR by endogenous ligand; Interleukin-20 family signaling,42,High,1
E9PAV3,"Nascent polypeptide-associated complex subunit alpha, muscle-specific form OS=Homo sapiens OX=9606 GN=NACA PE=1 SV=1",0,733.47,55,70,2032,70,2078,205.3,9.58,818173,969.09,52,35,metabolic process;regulation of biological process,cytoplasm;nucleus,DNA binding,Pf01849,4666,ENSG00000196531.10,NACA,12,,,,0,High,1
P07954,"Fumarate hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=FH PE=1 SV=3",0,732.637,70,50,4507,50,510,54.6,8.76,2116116,874.35,49,10,metabolic process,cytoplasm;mitochondrion;organelle lumen,catalytic activity;protein binding,"Pf00206, Pf10415",2271,ENSG00000091483.6,FH,1,Carbon metabolism; Pathways in cancer; Citrate cycle (TCA cycle); Metabolic pathways; Pyruvate metabolism; Renal cell carcinoma,TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc); Amino Acid metabolism; TCA Cycle,Citric acid cycle (TCA cycle),13,High,1
P11142,Heat shock cognate 71 kDa protein OS=Homo sapiens OX=9606 GN=HSPA8 PE=1 SV=1,0,731.577,67,63,4756,37,646,70.9,5.52,2299454,41.65,62,9,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;extracellular;membrane;nucleus;organelle lumen;spliceosomal complex,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00012, Pf02463, Pf06723",3312,ENSG00000109971.13,HSPA8,11,Protein processing in endoplasmic reticulum; Epstein-Barr virus infection; Estrogen signaling pathway; Toxoplasmosis; Spliceosome; Endocytosis; Antigen processing and presentation; Influenza A; Legionellosis; Measles; MAPK signaling pathway; Longevity regulating pathway - multiple species,Parkin-Ubiquitin Proteasomal System pathway; MAPK Signaling Pathway; Exercise-induced Circadian Regulation,"Protein methylation; Clathrin-mediated endocytosis; Regulation of HSF1-mediated heat shock response; Golgi Associated Vesicle Biogenesis; GABA synthesis, release, reuptake and degradation; Lysosome Vesicle Biogenesis; CHL1 interactions; AUF1 (hnRNP D0) binds and destabilizes mRNA; Attenuation phase; Neutrophil degranulation; mRNA Splicing - Major Pathway; Interleukin-4 and 13 signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR)",52,High,1
P04350,Tubulin beta-4A chain OS=Homo sapiens OX=9606 GN=TUBB4A PE=1 SV=2,0,729.482,72,62,4705,4,444,49.6,4.88,2339515,118.73,61,11,cell organization and biogenesis;regulation of biological process,cytoplasm;cytoskeleton;cytosol;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding;structural molecule activity,"Pf00091, Pf03953, Pf10644",10382,ENSG00000104833.11,TUBB4A,19,Phagosome; Pathogenic Escherichia coli infection; Gap junction,Pathogenic Escherichia coli infection; Parkin-Ubiquitin Proteasomal System pathway,COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Loss of Nlp from mitotic centrosomes; Translocation of GLUT4 to the plasma membrane; Prefoldin mediated transfer of substrate  to CCT/TriC; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Separation of Sister Chromatids; COPI-mediated anterograde transport; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR); Kinesins; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recruitment of mitotic centrosome proteins and complexes; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; Post-chaperonin tubulin folding pathway; RHO GTPases Activate Formins; MHC class II antigen presentation,72,High,1
Q8N3K9,Cardiomyopathy-associated protein 5 OS=Homo sapiens OX=9606 GN=CMYA5 PE=1 SV=3,0,724.453,35,93,457,93,4069,448.9,4.78,11837,1120.91,3,93,,cytoplasm,protein binding,"Pf00041, Pf00622",202333,ENSG00000164309.14,CMYA5,5,,,,0,High,1
Q9BX66-5,Isoform 5 of Sorbin and SH3 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SORBS1,0,724.104,59,65,2516,1,1004,111.7,6.29,1213887,114.37,60,16,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytosol;membrane;nucleus,protein binding,"Pf00018, Pf02208, Pf07653, Pf14604",10580,ENSG00000095637.21,SORBS1,10,,Integrin-mediated Cell Adhesion; PPAR signaling pathway; Insulin Signaling,,3,High,1
Q99959-2,Isoform 1 of Plakophilin-2 OS=Homo sapiens OX=9606 GN=PKP2,0,723.959,59,60,2144,60,837,92.7,9.29,1009333,484.23,52,15,cell communication;cell death;cell organization and biogenesis;regulation of biological process,cytoskeleton;membrane;nucleus,protein binding;structural molecule activity,Pf00514,5318,ENSG00000057294.14,PKP2,12,,Arrhythmogenic Right Ventricular Cardiomyopathy,,1,High,1
P45379,"Troponin T, cardiac muscle OS=Homo sapiens OX=9606 GN=TNNT2 PE=1 SV=3",0,723.887,46,51,11861,46,298,35.9,4.97,5544612,2042.84,51,14,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cytosol,catalytic activity;protein binding,Pf00992,7139,ENSG00000118194.18,TNNT2,1,Cardiac muscle contraction; Dilated cardiomyopathy; Hypertrophic cardiomyopathy (HCM); Adrenergic signaling in cardiomyocytes,Cardiac Progenitor Differentiation; Striated Muscle Contraction,Striated Muscle Contraction,8,High,1
Q03001,Dystonin OS=Homo sapiens OX=9606 GN=DST PE=1 SV=4,0,722.276,22,131,653,123,7570,860.1,5.25,277082,23.06,128,8,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;nucleus,metal ion binding;protein binding,"Pf00307, Pf00435, Pf00681, Pf02187, Pf11971, Pf13499, Pf13833",667,,DST,6,,,Type I hemidesmosome assembly,3,High,1
P35573,Glycogen debranching enzyme OS=Homo sapiens OX=9606 GN=AGL PE=1 SV=3,0,715.662,45,64,2050,64,1532,174.7,6.76,1016682,15.43,62,6,metabolic process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;extracellular;nucleus;organelle lumen,catalytic activity;protein binding,"Pf06202, Pf14699, Pf14701, Pf14702",178,ENSG00000162688.16,AGL,1,Starch and sucrose metabolism; Metabolic pathways,Glycogen Metabolism,Neutrophil degranulation; Glycogen breakdown (glycogenolysis),10,High,1
P01009,Alpha-1-antitrypsin OS=Homo sapiens OX=9606 GN=SERPINA1 PE=1 SV=3,0,704.428,73,62,7139,62,418,46.7,5.59,3434544,176.84,61,10,cell organization and biogenesis;coagulation;defense response;metabolic process;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;extracellular;Golgi;membrane;organelle lumen,enzyme regulator activity;protein binding,Pf00079,5265,ENSG00000197249.13,SERPINA1,14,Complement and coagulation cascades,NRF2 pathway; Lung fibrosis; Complement and Coagulation Cascades,Platelet degranulation ; Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Neutrophil degranulation; Cargo concentration in the ER; COPII (Coat Protein 2) Mediated Vesicle Transport,22,High,1
P02511,Alpha-crystallin B chain OS=Homo sapiens OX=9606 GN=CRYAB PE=1 SV=2,0,704.154,98,60,10067,59,175,20.1,7.33,5421546,67.09,59,8,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cell surface;cytoplasm;cytoskeleton;cytosol;Golgi;membrane;mitochondrion;nucleus,metal ion binding;protein binding;structural molecule activity,"Pf00011, Pf00525",1410,ENSG00000109846.7,CRYAB,11,Longevity regulating pathway - multiple species; Protein processing in endoplasmic reticulum,,HSF1-dependent transactivation,6,High,1
Q13885,Tubulin beta-2A chain OS=Homo sapiens OX=9606 GN=TUBB2A PE=1 SV=1,0,701.545,73,61,3802,1,445,49.9,4.89,1936060,111.27,60,10,cell organization and biogenesis,cytoplasm;cytoskeleton;nucleus,catalytic activity;nucleotide binding;protein binding;structural molecule activity,"Pf00091, Pf03953, Pf10644",7280,ENSG00000137267.5,TUBB2A,6,Gap junction; Phagosome; Pathogenic Escherichia coli infection,Pathogenic Escherichia coli infection; Parkin-Ubiquitin Proteasomal System pathway,COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Translocation of GLUT4 to the plasma membrane; Prefoldin mediated transfer of substrate  to CCT/TriC; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Separation of Sister Chromatids; COPI-mediated anterograde transport; HSP90 chaperone cycle for steroid hormone receptors (SHR); The role of GTSE1 in G2/M progression after G2 checkpoint; Kinesins; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; RHO GTPases Activate Formins; Post-chaperonin tubulin folding pathway; MHC class II antigen presentation,65,High,1
P08237,"ATP-dependent 6-phosphofructokinase, muscle type OS=Homo sapiens OX=9606 GN=PFKM PE=1 SV=2",0,701.212,57,55,5060,44,780,85.1,7.99,2419777,181.73,49,18,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,Pf00365,5213,ENSG00000152556.15,PFKM,12,Glycolysis / Gluconeogenesis; Fructose and mannose metabolism; Central carbon metabolism in cancer; RNA degradation; Pentose phosphate pathway; Carbon metabolism; Metabolic pathways; Biosynthesis of amino acids; AMPK signaling pathway; Galactose metabolism,Insulin Signaling; Glycolysis and Gluconeogenesis,Glycolysis,16,High,1
Q9BVA1,Tubulin beta-2B chain OS=Homo sapiens OX=9606 GN=TUBB2B PE=1 SV=1,0,700.426,73,61,3792,1,445,49.9,4.89,1929350,111.27,60,10,cell organization and biogenesis;cellular component movement;regulation of biological process,cytoplasm;cytoskeleton;nucleus,catalytic activity;nucleotide binding;protein binding;structural molecule activity,"Pf00091, Pf03953, Pf10644",347733,ENSG00000137285.9,TUBB2B,6,Gap junction; Phagosome; Pathogenic Escherichia coli infection,Pathogenic Escherichia coli infection; Parkin-Ubiquitin Proteasomal System pathway,COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Translocation of GLUT4 to the plasma membrane; Prefoldin mediated transfer of substrate  to CCT/TriC; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Separation of Sister Chromatids; COPI-mediated anterograde transport; HSP90 chaperone cycle for steroid hormone receptors (SHR); The role of GTSE1 in G2/M progression after G2 checkpoint; Kinesins; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; RHO GTPases Activate Formins; Post-chaperonin tubulin folding pathway; MHC class II antigen presentation,65,High,1
P08133,Annexin A6 OS=Homo sapiens OX=9606 GN=ANXA6 PE=1 SV=3,0,698.617,68,66,2928,65,673,75.8,5.6,1428847,49.54,64,14,cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport,cytoplasm;membrane;mitochondrion,metal ion binding;nucleotide binding;protein binding;transporter activity,Pf00191,309,ENSG00000197043.13,ANXA6,5,,Calcium Regulation in the Cardiac Cell; Prostaglandin Synthesis and Regulation,Smooth Muscle Contraction,4,High,1
P12235,ADP/ATP translocase 1 OS=Homo sapiens OX=9606 GN=SLC25A4 PE=1 SV=4,0,697.628,85,67,17031,21,298,33,9.76,9032547,713.32,55,25,cell organization and biogenesis;metabolic process;regulation of biological process;transport,membrane;mitochondrion;nucleus,protein binding;transporter activity,Pf00153,291,ENSG00000151729.10,SLC25A4,4,cGMP-PKG signaling pathway; HTLV-I infection; Parkinson's disease; Calcium signaling pathway; Huntington's disease,Electron Transport Chain; Synaptic Vesicle Pathway; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization; Mitochondrial protein import; Metabolism of proteins; Regulation of insulin secretion,19,High,1
P35527,"Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3",0,697.627,82,44,2290,43,623,62,5.24,1129657,146.14,42,10,cell death;cell organization and biogenesis,cytosol;membrane;nucleus,structural molecule activity,"Pf00038, Pf13166",3857,ENSG00000171403.9,KRT9,17,,,Formation of the cornified envelope,3,High,1
P13645,"Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6",0,696.929,60,62,2517,49,584,58.8,5.21,1333555,13.92,62,10,cell death;cell differentiation;metabolic process,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,structural molecule activity,"Pf00038, Pf04111",3858,ENSG00000186395.7,KRT10,17,Staphylococcus aureus infection,,Formation of the cornified envelope,4,High,1
P17174,"Aspartate aminotransferase, cytoplasmic OS=Homo sapiens OX=9606 GN=GOT1 PE=1 SV=3",0,682.766,83,51,3721,51,413,46.2,7.01,1901940,156.44,47,11,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;mitochondrion;nucleus;vacuole,catalytic activity,Pf00155,2805,ENSG00000120053.10,GOT1,10,"Biosynthesis of amino acids; Carbon metabolism; Phenylalanine, tyrosine and tryptophan biosynthesis; Metabolic pathways; Phenylalanine metabolism; Tyrosine metabolism; Arginine and proline metabolism; 2-Oxocarboxylic acid metabolism; Alanine, aspartate and glutamate metabolism; Arginine biosynthesis; Cysteine and methionine metabolism",Alanine and aspartate metabolism; Trans-sulfuration pathway; Amino Acid metabolism; Glycolysis and Gluconeogenesis,Gluconeogenesis; Amino acid synthesis and interconversion (transamination); Methionine salvage pathway,24,High,1
P24752,"Acetyl-CoA acetyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=ACAT1 PE=1 SV=1",0,680.837,79,55,4164,55,427,45.2,8.85,2223130,239.62,52,9,cell organization and biogenesis;metabolic process;response to stimulus,membrane;mitochondrion;organelle lumen,catalytic activity;metal ion binding;protein binding,"Pf00108, Pf00109, Pf02803",38,ENSG00000075239.13,ACAT1,11,"Terpenoid backbone biosynthesis; Lysine degradation; Fatty acid degradation; Fatty acid metabolism; Glyoxylate and dicarboxylate metabolism; Synthesis and degradation of ketone bodies; Carbon metabolism; Butanoate metabolism; Tryptophan metabolism; Valine, leucine and isoleucine degradation; Metabolic pathways; Pyruvate metabolism; Propanoate metabolism",Fatty Acid Beta Oxidation; Synthesis and Degradation of Ketone Bodies; Tryptophan metabolism,Synthesis of Ketone Bodies; Branched-chain amino acid catabolism; Utilization of Ketone Bodies,23,High,1
O75112-5,Isoform 5 of LIM domain-binding protein 3 OS=Homo sapiens OX=9606 GN=LDB3,0,680.443,81,49,3267,4,330,35.6,9.69,1468589,1031.5,46,14,cell organization and biogenesis,cytoskeleton,metal ion binding;protein binding,Pf00595,11155,ENSG00000122367.19,LDB3,10,,,,0,High,1
P13639,Elongation factor 2 OS=Homo sapiens OX=9606 GN=EEF2 PE=1 SV=4,0,672.07,59,62,3365,61,858,95.3,6.83,1595599,86,55,15,cell differentiation;cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen;ribosome,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00009, Pf00679, Pf03144, Pf03764, Pf14492",1938,ENSG00000167658.15,EEF2,19,Oxytocin signaling pathway; AMPK signaling pathway,Translation Factors; AMP-activated Protein Kinase (AMPK) Signaling; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway,Peptide chain elongation; Protein methylation; Synthesis of diphthamide-EEF2; Neutrophil degranulation; Uptake and function of diphtheria toxin,20,High,1
Q86VF7,Nebulin-related-anchoring protein OS=Homo sapiens OX=9606 GN=NRAP PE=1 SV=2,0,671.558,46,66,1450,66,1730,197,9.2,558338,757.65,48,37,,,metal ion binding;protein binding,"Pf00412, Pf00880",4892,ENSG00000197893.13,NRAP,10,,,,0,High,1
Q01484-5,Isoform 4 of Ankyrin-2 OS=Homo sapiens OX=9606 GN=ANK2,0,670.045,48,62,974,47,1863,204.6,6.23,427835,136.59,57,14,cell communication;cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport,cytoskeleton;cytosol;endosome;membrane;mitochondrion;vacuole,protein binding;structural molecule activity,"Pf00023, Pf00531, Pf00791, Pf12796, Pf13606, Pf13637, Pf13857",287,ENSG00000145362.17,ANK2,4,,,,0,High,1
Q16836,"Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=HADH PE=1 SV=3",0,661.854,75,49,6760,49,314,34.3,8.85,3232224,25.93,49,7,metabolic process;regulation of biological process;response to stimulus,cytoplasm;membrane;mitochondrion;organelle lumen,catalytic activity;nucleotide binding,"Pf00070, Pf00725, Pf01210, Pf01266, Pf02737, Pf03721, Pf13450",3033,ENSG00000138796.16,HADH,4,"Butanoate metabolism; Tryptophan metabolism; Fatty acid degradation; Valine, leucine and isoleucine degradation; Lysine degradation; Fatty acid metabolism; Fatty acid elongation; Metabolic pathways",Fatty Acid Beta Oxidation; Fatty Acid Biosynthesis; Mitochondrial LC-Fatty Acid Beta-Oxidation; Amino Acid metabolism; Tryptophan metabolism,Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA,23,High,1
P38646,"Stress-70 protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPA9 PE=1 SV=2",0,658.095,66,57,2859,52,679,73.6,6.16,1398712,56.96,55,15,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;mitochondrion;nucleus;organelle lumen,nucleotide binding;protein binding;RNA binding,"Pf00012, Pf06723",3313,ENSG00000113013.12,HSPA9,5,Tuberculosis; RNA degradation,Parkin-Ubiquitin Proteasomal System pathway,Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Mitochondrial protein import; Regulation of HSF1-mediated heat shock response; Interleukin-12 family signaling; Cristae formation; Metabolism of proteins,17,High,1
O94875-2,Isoform 2 of Sorbin and SH3 domain-containing protein 2 OS=Homo sapiens OX=9606 GN=SORBS2,0,656.418,65,48,3362,2,666,74.7,8.98,1544625,695.06,44,18,cell growth;cell organization and biogenesis,cytoskeleton;membrane;nucleus,protein binding;RNA binding;structural molecule activity,"Pf00018, Pf02208, Pf07653, Pf14604",8470,ENSG00000154556.17,SORBS2,4,,,,0,High,1
P10916,"Myosin regulatory light chain 2, ventricular/cardiac muscle isoform OS=Homo sapiens OX=9606 GN=MYL2 PE=1 SV=3",0,654.576,95,53,12782,47,166,18.8,5,6646796,203.19,49,17,cell organization and biogenesis;cellular component movement;regulation of biological process,cytoplasm;cytoskeleton;cytosol,metal ion binding;protein binding;structural molecule activity,"Pf00036, Pf13405",4633,ENSG00000111245.14,MYL2,12,Leukocyte transendothelial migration; Adrenergic signaling in cardiomyocytes; Hypertrophic cardiomyopathy (HCM); Regulation of actin cytoskeleton; Dilated cardiomyopathy; Cardiac muscle contraction; Focal adhesion; Tight junction,Cardiac Progenitor Differentiation; Myometrial Relaxation and Contraction Pathways; Striated Muscle Contraction; VEGFA-VEGFR2 Signaling Pathway,Striated Muscle Contraction,14,High,1
P11532-15,Isoform 9 of Dystrophin OS=Homo sapiens OX=9606 GN=DMD,0,646.032,49,53,1732,1,1230,141.7,5.82,862183,102.54,47,20,,,,,,,,,,,,0,High,1
O94875-8,Isoform 8 of Sorbin and SH3 domain-containing protein 2 OS=Homo sapiens OX=9606 GN=SORBS2,0,644.555,67,49,3223,1,661,73.8,9.16,1544625,373.56,44,19,cell growth;cell organization and biogenesis,cytoskeleton;membrane;nucleus,protein binding;RNA binding;structural molecule activity,"Pf00018, Pf02208, Pf07653, Pf14604",8470,ENSG00000154556.17,SORBS2,4,,,,0,High,1
Q9UPN3-5,"Isoform 4 of Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 OS=Homo sapiens OX=9606 GN=MACF1",0,641.875,26,120,485,2,5938,669.7,5.3,207964,7.63,117,4,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;Golgi;membrane,catalytic activity;metal ion binding;motor activity;protein binding;RNA binding,"Pf00036, Pf00435, Pf00681, Pf01576, Pf02187, Pf10498, Pf13499, Pf13514, Pf13833",23499,ENSG00000127603.23,MACF1,1,,Mesodermal Commitment Pathway,,1,High,1
P09493,Tropomyosin alpha-1 chain OS=Homo sapiens OX=9606 GN=TPM1 PE=1 SV=2,0,641.829,69,59,10270,4,284,32.7,4.74,5639161,241.6,59,12,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol,protein binding;structural molecule activity,"Pf00261, Pf12718",7168,ENSG00000140416.19,TPM1,15,Hypertrophic cardiomyopathy (HCM); Dilated cardiomyopathy; MicroRNAs in cancer; Adrenergic signaling in cardiomyocytes; Cardiac muscle contraction,Striated Muscle Contraction,Smooth Muscle Contraction; Striated Muscle Contraction,9,High,1
P48681,Nestin OS=Homo sapiens OX=9606 GN=NES PE=1 SV=2,0,640.074,59,67,982,67,1621,177.3,4.36,489293,14.89,64,9,cell organization and biogenesis;cell proliferation;development;regulation of biological process,cytoplasm;cytoskeleton,protein binding;structural molecule activity,Pf00038,10763,ENSG00000132688.10,NES,1,,,,0,High,1
Q9BX66-3,Isoform 3 of Sorbin and SH3 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SORBS1,0,638.191,60,60,2429,1,905,101,7.43,1183062,45.33,55,13,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytosol;membrane;nucleus,protein binding,"Pf00018, Pf02208, Pf07653, Pf14604",10580,ENSG00000095637.21,SORBS1,10,,Integrin-mediated Cell Adhesion; PPAR signaling pathway; Insulin Signaling,,3,High,1
P21980,Protein-glutamine gamma-glutamyltransferase 2 OS=Homo sapiens OX=9606 GN=TGM2 PE=1 SV=2,0,627.759,57,59,1968,59,687,77.3,5.22,1015505,68.45,52,14,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;membrane;mitochondrion,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00868, Pf00927, Pf01841",7052,ENSG00000198959.11,TGM2,20,Huntington's disease,,,1,High,1
P00558,Phosphoglycerate kinase 1 OS=Homo sapiens OX=9606 GN=PGK1 PE=1 SV=3,0,627.197,65,53,4313,53,417,44.6,8.1,2068762,200.16,51,13,cell differentiation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;nucleotide binding;protein binding,Pf00162,5230,ENSG00000102144.13,PGK1,X,Biosynthesis of amino acids; HIF-1 signaling pathway; Metabolic pathways; Carbon metabolism; Glycolysis / Gluconeogenesis,Cori Cycle; Photodynamic therapy-induced HIF-1 survival signaling; Glycolysis and Gluconeogenesis,Gluconeogenesis; Glycolysis,13,High,1
O60313-2,"Isoform 2 of Dynamin-like 120 kDa protein, mitochondrial OS=Homo sapiens OX=9606 GN=OPA1",0,626.698,56,64,2020,64,997,115.8,7.87,985177,87.24,59,11,cell death;cell organization and biogenesis;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;membrane;mitochondrion,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00350, Pf01926",4976,ENSG00000198836.8,OPA1,3,,,,0,High,1
Q05639,Elongation factor 1-alpha 2 OS=Homo sapiens OX=9606 GN=EEF1A2 PE=1 SV=1,0,625.239,65,52,4611,31,463,50.4,9.03,2268087,120.58,51,10,metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00009, Pf03143, Pf03144",1917,ENSG00000101210.10,EEF1A2,20,RNA transport; Legionellosis,Translation Factors,Eukaryotic Translation Elongation,6,High,1
Q9UMS6-2,Isoform 2 of Synaptopodin-2 OS=Homo sapiens OX=9606 GN=SYNPO2,0,622.132,50,55,1578,3,1261,136.3,8.79,767997,94.44,50,16,cell organization and biogenesis;regulation of biological process,cytoskeleton;cytosol;nucleus,protein binding,Pf00595,171024,ENSG00000172403.10,SYNPO2,4,,,,0,High,1
P02144,Myoglobin OS=Homo sapiens OX=9606 GN=MB PE=1 SV=2,0,619.203,90,49,16533,49,154,17.2,7.68,9830694,64.54,46,7,cell differentiation;response to stimulus;transport,cytosol,metal ion binding;transporter activity,Pf00042,4151,ENSG00000198125.12,MB,22,,Effects of Nitric Oxide,Intracellular oxygen transport,3,High,1
P78527,DNA-dependent protein kinase catalytic subunit OS=Homo sapiens OX=9606 GN=PRKDC PE=1 SV=3,0,619.063,28,102,810,100,4128,468.8,7.12,341142,1.79,102,8,cell death;cell differentiation;cell organization and biogenesis;cell proliferation;defense response;metabolic process;regulation of biological process;response to stimulus,cytosol;membrane;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding,"Pf00454, Pf02259, Pf02260, Pf08163",5591,ENSG00000253729.7,PRKDC,8,Cell cycle; Non-homologous end-joining,miRNA Regulation of DNA Damage Response; Cell Cycle; Retinoblastoma (RB) in Cancer; Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation; Pathways Affected in Adenoid Cystic Carcinoma; ATM Signaling Network in Development and Disease; Non-homologous end joining; DNA Damage Response,Nonhomologous End-Joining (NHEJ); E3 ubiquitin ligases ubiquitinate target proteins; IRF3-mediated induction of type I IFN,22,High,1
P04179,"Superoxide dismutase [Mn], mitochondrial OS=Homo sapiens OX=9606 GN=SOD2 PE=1 SV=3",0,617.062,85,43,3563,43,222,24.7,8.25,1744864,24.85,42,7,,,,,,,,,,,,0,High,1
P06733,Alpha-enolase OS=Homo sapiens OX=9606 GN=ENO1 PE=1 SV=2,0,616.569,67,52,3274,39,434,47.1,7.39,1535943,48.96,50,9,metabolic process;regulation of biological process;response to stimulus,cell surface;cytoplasm;cytosol;membrane;nucleus,catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding,"Pf00113, Pf03952, Pf13378",2023,ENSG00000074800.13,ENO1,1,Metabolic pathways; Glycolysis / Gluconeogenesis; Biosynthesis of amino acids; Carbon metabolism; RNA degradation; HIF-1 signaling pathway,Glycolysis and Gluconeogenesis,Gluconeogenesis; Glycolysis,12,High,1
Q9UMS6,Synaptopodin-2 OS=Homo sapiens OX=9606 GN=SYNPO2 PE=1 SV=2,0,613.468,55,54,1594,2,1093,117.4,8.57,781809,43.53,52,13,cell organization and biogenesis;regulation of biological process,cytoplasm;cytoskeleton;cytosol;nucleus,protein binding,Pf00595,171024,ENSG00000172403.10,SYNPO2,4,,,,0,High,1
P04792,Heat shock protein beta-1 OS=Homo sapiens OX=9606 GN=HSPB1 PE=1 SV=2,0,611.838,88,45,3757,45,205,22.8,6.4,1973603,6.08,45,5,cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane;nucleus;proteasome,enzyme regulator activity;protein binding;RNA binding,Pf00011,3315,ENSG00000106211.8,HSPB1,7,Epstein-Barr virus infection; MAPK signaling pathway; Amoebiasis; VEGF signaling pathway,Apoptosis-related network due to altered Notch3 in ovarian cancer; Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation; MAPK Signaling Pathway; ATM Signaling Network in Development and Disease; VEGFA-VEGFR2 Signaling Pathway; p38 MAPK Signaling Pathway,AUF1 (hnRNP D0) binds and destabilizes mRNA; VEGFA-VEGFR2 Pathway; MAPK6/MAPK4 signaling,19,High,1
O94875-11,Isoform 11 of Sorbin and SH3 domain-containing protein 2 OS=Homo sapiens OX=9606 GN=SORBS2,0,606,37,50,3194,1,1200,134.5,8.53,1550611,117.31,46,18,cell growth;cell organization and biogenesis,cytoskeleton;membrane;nucleus,protein binding;RNA binding;structural molecule activity,"Pf00018, Pf02208, Pf07653, Pf14604",8470,ENSG00000154556.17,SORBS2,4,,,,0,High,1
Q7Z6Z7,E3 ubiquitin-protein ligase HUWE1 OS=Homo sapiens OX=9606 GN=HUWE1 PE=1 SV=3,0,604.898,24,77,658,76,4374,481.6,5.22,315036,0,77,1,cell differentiation;cell organization and biogenesis;metabolic process;response to stimulus;transport,cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen,catalytic activity;DNA binding;protein binding;RNA binding,"Pf00632, Pf02825, Pf06012, Pf06025, Pf14377",10075,ENSG00000086758.15,HUWE1,X,Ubiquitin mediated proteolysis,,Neutrophil degranulation; Antigen processing: Ubiquitination & Proteasome degradation,7,High,1
Q14697,Neutral alpha-glucosidase AB OS=Homo sapiens OX=9606 GN=GANAB PE=1 SV=3,0,603.879,54,58,1338,2,944,106.8,6.14,644736,1.76,58,1,metabolic process,endoplasmic reticulum;Golgi;membrane;organelle lumen,catalytic activity;RNA binding,"Pf01055, Pf13802",23193,ENSG00000089597.16,GANAB,11,N-Glycan biosynthesis; Protein processing in endoplasmic reticulum; Metabolic pathways,,Calnexin/calreticulin cycle,8,High,1
P49411,"Elongation factor Tu, mitochondrial OS=Homo sapiens OX=9606 GN=TUFM PE=1 SV=2",0,594.89,67,53,3584,52,452,49.5,7.61,1776705,143.56,49,12,metabolic process;response to stimulus,membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00009, Pf03143, Pf03144",7284,,TUFM,16,,,Mitochondrial translation elongation,4,High,1
P22314,Ubiquitin-like modifier-activating enzyme 1 OS=Homo sapiens OX=9606 GN=UBA1 PE=1 SV=3,0,593.71,55,54,1444,54,1058,117.8,5.76,728341,12.19,53,6,metabolic process;response to stimulus,cytoplasm;cytosol;membrane;mitochondrion;nucleus,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00899, Pf02134, Pf09358, Pf10585",7317,ENSG00000130985.16,UBA1,X,Ubiquitin mediated proteolysis; Parkinson's disease,Proteasome Degradation; Parkin-Ubiquitin Proteasomal System pathway; Parkinsons Disease Pathway,Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation,13,High,1
Q96HC4-6,Isoform 6 of PDZ and LIM domain protein 5 OS=Homo sapiens OX=9606 GN=PDLIM5,0,593.28,56,46,3319,6,625,67.7,8.37,1421232,1566.38,37,16,cell growth;regulation of biological process,cytoskeleton;cytosol;membrane,metal ion binding;protein binding,"Pf00412, Pf00595, Pf13180",10611,ENSG00000163110.14,PDLIM5,4,,,,0,High,1
Q9BX66-6,Isoform 6 of Sorbin and SH3 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SORBS1,0,592.458,59,57,2235,1,846,95,6.6,1081252,56.06,53,11,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytosol;membrane;nucleus,protein binding,"Pf00018, Pf02208, Pf07653, Pf14604",10580,,SORBS1,10,,Integrin-mediated Cell Adhesion; PPAR signaling pathway; Insulin Signaling,,3,High,1
P11217,"Glycogen phosphorylase, muscle form OS=Homo sapiens OX=9606 GN=PYGM PE=1 SV=6",0,587.97,56,55,2000,35,842,97,7.03,969558,85.81,54,16,metabolic process,cytoplasm;cytosol,catalytic activity;nucleotide binding;protein binding,Pf00343,5837,ENSG00000068976.13,PYGM,11,Insulin resistance; Starch and sucrose metabolism; Insulin signaling pathway; Metabolic pathways; Glucagon signaling pathway,Glycogen Metabolism,Glycogen breakdown (glycogenolysis),10,High,1
P14625,Endoplasmin OS=Homo sapiens OX=9606 GN=HSP90B1 PE=1 SV=1,0,586.095,53,52,1702,49,803,92.4,4.84,817970,0,52,7,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;endoplasmic reticulum;extracellular;membrane;nucleus;organelle lumen,metal ion binding;nucleotide binding;protein binding;RNA binding,"Pf00183, Pf02518, Pf13589",7184,ENSG00000166598.14,HSP90B1,12,Thyroid hormone synthesis; Pathways in cancer; Estrogen signaling pathway; Prostate cancer; PI3K-Akt signaling pathway; Protein processing in endoplasmic reticulum,Photodynamic therapy-induced unfolded protein response; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); ATF6 (ATF6-alpha) activates chaperone genes; Interleukin-4 and 13 signaling; Trafficking and processing of endosomal TLR; Scavenging by Class A Receptors,26,High,1
Q14697-2,Isoform 2 of Neutral alpha-glucosidase AB OS=Homo sapiens OX=9606 GN=GANAB,0,585.691,53,57,1323,1,966,109.4,6.24,634958,14.57,56,2,metabolic process,Golgi;membrane;organelle lumen,catalytic activity;RNA binding,"Pf01055, Pf13802",23193,ENSG00000089597.16,GANAB,11,,,,0,High,1
A4UGR9,Xin actin-binding repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=XIRP2 PE=1 SV=2,0,581.671,33,79,578,78,3374,382.1,6.38,132974,637.21,30,60,cell organization and biogenesis,,protein binding,Pf08043,129446,ENSG00000163092.19,XIRP2,2,,,,0,High,1
P40926,"Malate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=MDH2 PE=1 SV=3",0,580.596,73,62,6838,62,338,35.5,8.68,3486769,330.92,58,13,metabolic process,membrane;mitochondrion;nucleus;organelle lumen,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00056, Pf01073, Pf01118, Pf02866, Pf13460",4191,ENSG00000146701.11,MDH2,7,Metabolic pathways; Citrate cycle (TCA cycle); Glyoxylate and dicarboxylate metabolism; Pyruvate metabolism; Cysteine and methionine metabolism; Carbon metabolism,Amino Acid metabolism; Glycolysis and Gluconeogenesis; TCA Cycle,Gluconeogenesis; Citric acid cycle (TCA cycle),16,High,1
O95831,"Apoptosis-inducing factor 1, mitochondrial OS=Homo sapiens OX=9606 GN=AIFM1 PE=1 SV=1",0,578.652,69,54,2300,54,613,66.9,8.95,1168582,68.08,52,12,cell death;cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;mitochondrion;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding,"Pf00070, Pf07992, Pf14721, Pf14962",9131,ENSG00000156709.13,AIFM1,X,Apoptosis,Apoptosis Modulation and Signaling; Nanomaterial induced apoptosis; Apoptosis Modulation by HSP70,,4,High,1
P02042,Hemoglobin subunit delta OS=Homo sapiens OX=9606 GN=HBD PE=1 SV=2,0,578.246,96,53,18360,13,147,16,8.05,10507337,55.99,51,8,coagulation;transport,cytosol,metal ion binding;protein binding;transporter activity,Pf00042,3045,ENSG00000223609.7,HBD,11,,,Factors involved in megakaryocyte development and platelet production,2,High,1
P02545-2,Isoform C of Prelamin-A/C OS=Homo sapiens OX=9606 GN=LMNA,0,575.446,64,49,2084,1,572,65.1,6.84,1052579,163.39,47,12,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytosol;membrane;nucleus,protein binding;structural molecule activity,"Pf00038, Pf00932",4000,ENSG00000160789.19,LMNA,1,,Arrhythmogenic Right Ventricular Cardiomyopathy; Adipogenesis; Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation,Meiotic synapsis; Depolymerisation of the Nuclear Lamina; Initiation of Nuclear Envelope Reformation; Clearance of Nuclear Envelope Membranes from Chromatin,17,High,1
P36957,"Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DLST PE=1 SV=4",0,575.388,65,51,2073,51,453,48.7,8.95,972134,524.49,49,4,metabolic process,membrane;mitochondrion;nucleus;organelle lumen,catalytic activity,"Pf00198, Pf00364",1743,ENSG00000119689.14,DLST,14,Carbon metabolism; Lysine degradation; Metabolic pathways; Citrate cycle (TCA cycle),TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc); Amino Acid metabolism; TCA Cycle,Lysine catabolism; Glyoxylate metabolism and glycine degradation; Citric acid cycle (TCA cycle),15,High,1
P02545,Prelamin-A/C OS=Homo sapiens OX=9606 GN=LMNA PE=1 SV=1,0,571.531,59,52,2119,4,664,74.1,7.02,1101521,25.24,51,11,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytosol;membrane;nucleus,protein binding;structural molecule activity,"Pf00038, Pf00932",4000,ENSG00000160789.19,LMNA,1,Dilated cardiomyopathy; Hypertrophic cardiomyopathy (HCM); Apoptosis; Arrhythmogenic right ventricular cardiomyopathy (ARVC),Arrhythmogenic Right Ventricular Cardiomyopathy; Adipogenesis; Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation,Signaling by BRAF and RAF fusions; Breakdown of the nuclear lamina; XBP1(S) activates chaperone genes; Initiation of Nuclear Envelope Reformation; Clearance of Nuclear Envelope Membranes from Chromatin; Depolymerisation of the Nuclear Lamina; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models,33,High,1
P02679,Fibrinogen gamma chain OS=Homo sapiens OX=9606 GN=FGG PE=1 SV=3,0,564.803,62,50,2320,49,453,51.5,5.62,1178343,134.6,46,10,cell organization and biogenesis;coagulation;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;extracellular;membrane;organelle lumen,catalytic activity;metal ion binding;protein binding;structural molecule activity,"Pf00147, Pf08317, Pf08702, Pf15397",2266,ENSG00000171557.16,FGG,4,Staphylococcus aureus infection; Platelet activation; Complement and coagulation cascades,Blood Clotting Cascade; VEGFA-VEGFR2 Signaling Pathway,Post-translational protein phosphorylation; Integrin cell surface interactions; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Signaling by BRAF and RAF fusions; MAP2K and MAPK activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; p130Cas linkage to MAPK signaling for integrins; Platelet degranulation ; Paradoxical activation of RAF signaling by kinase inactive BRAF; Common Pathway of Fibrin Clot Formation; Regulation of TLR by endogenous ligand; Interleukin-20 family signaling,42,High,1
P07195,L-lactate dehydrogenase B chain OS=Homo sapiens OX=9606 GN=LDHB PE=1 SV=2,0,562.913,81,53,6841,50,334,36.6,6.05,3448588,477.42,51,9,metabolic process,cytoplasm;cytosol;membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding,"Pf00056, Pf02866",3945,ENSG00000111716.12,LDHB,12,Cysteine and methionine metabolism; Glucagon signaling pathway; Glycolysis / Gluconeogenesis; Propanoate metabolism; Metabolic pathways; Pyruvate metabolism,Glycolysis and Gluconeogenesis,Pyruvate metabolism,11,High,1
P0DMV9,Heat shock 70 kDa protein 1B OS=Homo sapiens OX=9606 GN=HSPA1B PE=1 SV=1,0,560.191,66,53,2802,24,641,70,5.66,1406351,9.32,52,8,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;extracellular;mitochondrion;nucleus,catalytic activity;nucleotide binding;protein binding;receptor activity;RNA binding,"Pf00012, Pf06723",3304; 3303,ENSG00000232804.5; ENSG00000234475.5; ENSG00000231555.4; ENSG00000235941.5; ENSG00000204389.9; ENSG00000204388.6; ENSG00000212866.6; ENSG00000237724.5; ENSG00000224501.5,HSPA1B; HSPA1A,6; CHR_HSCHR6_MHC_APD_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_COX_CTG1,Protein processing in endoplasmic reticulum; Estrogen signaling pathway; Prion diseases; MAPK signaling pathway; Influenza A; Longevity regulating pathway - multiple species; Measles; Antigen processing and presentation; Endocytosis; Spliceosome; Toxoplasmosis; Legionellosis; Epstein-Barr virus infection,Apoptosis Modulation and Signaling; Parkin-Ubiquitin Proteasomal System pathway; NRF2 pathway; MAPK Signaling Pathway; Apoptosis Modulation by HSP70; VEGFA-VEGFR2 Signaling Pathway,AUF1 (hnRNP D0) binds and destabilizes mRNA; Attenuation phase; Neutrophil degranulation; Regulation of HSF1-mediated heat shock response; Viral RNP Complexes in the Host Cell Nucleus; HSP90 chaperone cycle for steroid hormone receptors (SHR),38,High,1
Q12955-4,Isoform 2 of Ankyrin-3 OS=Homo sapiens OX=9606 GN=ANK3,0,559.868,43,59,823,42,1868,204,6.93,361344,64.36,56,14,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cell surface;cytoskeleton;cytosol;endoplasmic reticulum;Golgi;membrane;vacuole,protein binding;structural molecule activity,"Pf00023, Pf00531, Pf00791, Pf12796, Pf13606, Pf13637, Pf13857",288,ENSG00000151150.21,ANK3,10,,,,0,High,1
P46940,Ras GTPase-activating-like protein IQGAP1 OS=Homo sapiens OX=9606 GN=IQGAP1 PE=1 SV=1,0,559.36,51,73,926,66,1657,189.1,6.48,408148,0,73,1,cell growth;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,enzyme regulator activity;metal ion binding;protein binding,"Pf00307, Pf00397, Pf00616, Pf03836, Pf11016",8826,ENSG00000140575.12,IQGAP1,15,Proteoglycans in cancer; Regulation of actin cytoskeleton; Adherens junction,VEGFA-VEGFR2 Signaling Pathway; EGF/EGFR Signaling Pathway; Regulation of Actin Cytoskeleton; G13 Signaling Pathway,Signaling by BRAF and RAF fusions; MAP2K and MAPK activation; RHO GTPases activate IQGAPs; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; Nephrin family interactions; Paradoxical activation of RAF signaling by kinase inactive BRAF; Neutrophil degranulation; Interleukin-20 family signaling,35,High,1
P21399,Cytoplasmic aconitate hydratase OS=Homo sapiens OX=9606 GN=ACO1 PE=1 SV=3,0,558.697,54,41,2283,40,889,98.3,6.68,1104376,22.2,40,3,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;Golgi;mitochondrion,catalytic activity;metal ion binding;protein binding;RNA binding,"Pf00330, Pf00694",48,ENSG00000122729.18,ACO1,9,Glyoxylate and dicarboxylate metabolism; Biosynthesis of amino acids; Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Citrate cycle (TCA cycle),Iron metabolism in placenta; TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc),Iron uptake and transport,10,High,1
Q16795,"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFA9 PE=1 SV=2",0,556.124,75,47,4414,47,377,42.5,9.8,2283074,146.91,45,11,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion;nucleus;organelle lumen,catalytic activity;protein binding,"Pf01073, Pf01370, Pf05368",4704,ENSG00000139180.10,NDUFA9,12,Huntington's disease; Oxidative phosphorylation; Metabolic pathways; Parkinson's disease; Non-alcoholic fatty liver disease (NAFLD); Alzheimer's disease,Electron Transport Chain; Oxidative phosphorylation,Complex I biogenesis,13,High,1
Q9H987,Synaptopodin 2-like protein OS=Homo sapiens OX=9606 GN=SYNPO2L PE=2 SV=3,0,555.462,62,40,1742,7,977,102.4,9.74,865382,417.47,30,18,regulation of biological process,cytoplasm;cytoskeleton;cytosol;nucleus,protein binding,Pf00595,79933,ENSG00000166317.11,SYNPO2L,10,,,,0,High,1
P55268,Laminin subunit beta-2 OS=Homo sapiens OX=9606 GN=LAMB2 PE=1 SV=2,0,554.791,32,49,1205,48,1798,195.9,6.52,579374,14.06,48,6,cell growth;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport,cytoplasm;extracellular;Golgi;organelle lumen,catalytic activity;motor activity;nucleotide binding;protein binding;structural molecule activity;transporter activity,"Pf00053, Pf00055, Pf00430, Pf00769, Pf01576, Pf02050, Pf02841, Pf04111, Pf06008, Pf09831, Pf12128, Pf12795, Pf13514, Pf13851, Pf13868, Pf15070, Pf15558",3913,ENSG00000172037.13,LAMB2,3,Small cell lung cancer; Pathways in cancer; PI3K-Akt signaling pathway; Focal adhesion; Amoebiasis; ECM-receptor interaction; Toxoplasmosis,Alpha 6 Beta 4 signaling pathway; Primary Focal Segmental Glomerulosclerosis FSGS; miRNA targets in ECM and membrane receptors; Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Inflammatory Response Pathway,ECM proteoglycans; Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Laminin interactions; MET activates PTK2 signaling; Non-integrin membrane-ECM interactions,26,High,1
P55809,"Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=OXCT1 PE=1 SV=1",0,554.781,66,39,3063,37,520,56.1,7.46,1483350,65.07,37,7,metabolic process;regulation of biological process;response to stimulus,mitochondrion;organelle lumen,catalytic activity;protein binding,Pf01144,5019,ENSG00000083720.12,OXCT1,5,"Butanoate metabolism; Valine, leucine and isoleucine degradation; Synthesis and degradation of ketone bodies",Synthesis and Degradation of Ketone Bodies,Utilization of Ketone Bodies,8,High,1
A3KMH1,von Willebrand factor A domain-containing protein 8 OS=Homo sapiens OX=9606 GN=VWA8 PE=1 SV=2,0,553.327,48,81,874,81,1905,214.7,7.4,380749,10.61,81,11,,mitochondrion,catalytic activity;nucleotide binding,"Pf00092, Pf07728, Pf13191, Pf13519",23078,ENSG00000102763.17,VWA8,13,,,,0,High,1
P11047,Laminin subunit gamma-1 OS=Homo sapiens OX=9606 GN=LAMC1 PE=1 SV=3,0,552.893,30,43,1183,41,1609,177.5,5.12,605787,43.77,42,8,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process,extracellular;organelle lumen,catalytic activity;motor activity;protein binding;structural molecule activity,"Pf00052, Pf00053, Pf00055, Pf00261, Pf01576, Pf05262, Pf05483, Pf05557, Pf05667, Pf05701, Pf06008, Pf08317, Pf10174, Pf11068, Pf12128, Pf12795, Pf13166, Pf13514, Pf13868",3915,ENSG00000135862.5,LAMC1,1,Pathways in cancer; Focal adhesion; Amoebiasis; PI3K-Akt signaling pathway; Small cell lung cancer; Toxoplasmosis; Prion diseases; ECM-receptor interaction,Alpha 6 Beta 4 signaling pathway; Endoderm Differentiation; miRNA targets in ECM and membrane receptors; Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Inflammatory Response Pathway,ECM proteoglycans; Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); L1CAM interactions; Laminin interactions; Degradation of the extracellular matrix; MET activates PTK2 signaling; Non-integrin membrane-ECM interactions,31,High,1
O95425,Supervillin OS=Homo sapiens OX=9606 GN=SVIL PE=1 SV=2,0,552.701,41,73,713,73,2214,247.6,6.98,304575,7.28,72,7,cell organization and biogenesis;regulation of biological process,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,protein binding,"Pf00626, Pf02209",6840,ENSG00000197321.14,SVIL,10,,,,0,High,1
P09972,Fructose-bisphosphate aldolase C OS=Homo sapiens OX=9606 GN=ALDOC PE=1 SV=2,0,551.564,81,50,2138,34,364,39.4,6.87,1123611,91.38,47,8,cell differentiation;metabolic process;transport,cytoskeleton;cytosol;extracellular;mitochondrion;organelle lumen,catalytic activity;protein binding,Pf00274,230,ENSG00000109107.13,ALDOC,17,Metabolic pathways; Pentose phosphate pathway; Biosynthesis of amino acids; Fructose and mannose metabolism; Glycolysis / Gluconeogenesis; Carbon metabolism,Glycolysis and Gluconeogenesis,Gluconeogenesis; Glycolysis; Neutrophil degranulation,15,High,1
P00387,NADH-cytochrome b5 reductase 3 OS=Homo sapiens OX=9606 GN=CYB5R3 PE=1 SV=3,0,550.769,69,44,1636,42,301,34.2,7.59,837546,31.66,43,4,metabolic process;transport,cytoplasm;endoplasmic reticulum;extracellular;membrane;mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding,"Pf00175, Pf00970, Pf08030",1727,ENSG00000100243.20,CYB5R3,22,Amino sugar and nucleotide sugar metabolism,Oxidation by Cytochrome P450,Vitamin C (ascorbate) metabolism; Neutrophil degranulation; Phase I - Functionalization of compounds,11,High,1
P17540,"Creatine kinase S-type, mitochondrial OS=Homo sapiens OX=9606 GN=CKMT2 PE=1 SV=2",0,549.418,60,38,9734,33,419,47.5,8.19,4797370,895.45,35,15,metabolic process,membrane;mitochondrion,catalytic activity;nucleotide binding,"Pf00217, Pf02807",1160,ENSG00000131730.15,CKMT2,5,Metabolic pathways; Arginine and proline metabolism,,Creatine metabolism,6,High,1
P13929,Beta-enolase OS=Homo sapiens OX=9606 GN=ENO3 PE=1 SV=5,0,548.823,65,43,4179,28,434,47,7.71,1943075,391.73,40,12,metabolic process,cytoplasm;cytosol;membrane,catalytic activity;metal ion binding,"Pf00113, Pf03952, Pf13378",2027,ENSG00000108515.17,ENO3,17,RNA degradation; Carbon metabolism; Biosynthesis of amino acids; Glycolysis / Gluconeogenesis; HIF-1 signaling pathway; Metabolic pathways,Glycolysis and Gluconeogenesis,Gluconeogenesis; Glycolysis,12,High,1
P11021,Endoplasmic reticulum chaperone BiP OS=Homo sapiens OX=9606 GN=HSPA5 PE=1 SV=2,0,545.989,54,51,2350,44,654,72.3,5.16,1218618,8.56,50,6,cell communication;cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;endoplasmic reticulum;membrane;mitochondrion;nucleus;organelle lumen,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00012, Pf01968, Pf06723",3309,ENSG00000044574.7,HSPA5,9,Prion diseases; Protein processing in endoplasmic reticulum; Antigen processing and presentation; Protein export; Thyroid hormone synthesis,Parkin-Ubiquitin Proteasomal System pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Photodynamic therapy-induced unfolded protein response; MAPK Signaling Pathway,"Platelet degranulation ; PERK regulates gene expression; ATF6 (ATF6-alpha) activates chaperone genes; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Regulation of HSF1-mediated heat shock response; IRE1alpha activates chaperones",27,High,1
O75746,Calcium-binding mitochondrial carrier protein Aralar1 OS=Homo sapiens OX=9606 GN=SLC25A12 PE=1 SV=2,0,545.437,72,45,2582,35,678,74.7,8.38,1307278,80.14,42,17,metabolic process;response to stimulus;transport,membrane;mitochondrion,metal ion binding;transporter activity,"Pf00153, Pf13499",8604,ENSG00000115840.13,SLC25A12,2,,,Gluconeogenesis; Mitochondrial protein import; Metabolism of proteins,6,High,1
Q6YN16,Hydroxysteroid dehydrogenase-like protein 2 OS=Homo sapiens OX=9606 GN=HSDL2 PE=1 SV=1,0,541.158,78,43,2371,43,418,45.4,7.99,1087669,196.76,40,13,metabolic process,membrane;mitochondrion,catalytic activity,"Pf00106, Pf02036, Pf13561, Pf14864",84263,ENSG00000119471.14,HSDL2,9,,,,0,High,1
Q9NZN4,EH domain-containing protein 2 OS=Homo sapiens OX=9606 GN=EHD2 PE=1 SV=2,0,539.2,71,48,1793,41,543,61.1,6.46,899099,57.55,47,10,cell organization and biogenesis;coagulation;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;endosome;membrane;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00350, Pf01926, Pf12763",30846,ENSG00000024422.11,EHD2,19,Endocytosis,Insulin Signaling,Factors involved in megakaryocyte development and platelet production,4,High,1
Q01813,"ATP-dependent 6-phosphofructokinase, platelet type OS=Homo sapiens OX=9606 GN=PFKP PE=1 SV=2",0,536.485,52,45,1759,37,784,85.5,7.55,866398,106.47,41,11,metabolic process,cytoplasm;cytosol;membrane;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,Pf00365,5214,ENSG00000067057.16,PFKP,10,RNA degradation; Thyroid hormone signaling pathway; Metabolic pathways; AMPK signaling pathway; Carbon metabolism; Fructose and mannose metabolism; Galactose metabolism; Biosynthesis of amino acids; Central carbon metabolism in cancer; Glycolysis / Gluconeogenesis; Pentose phosphate pathway,Cori Cycle; Glycolysis and Gluconeogenesis,Glycolysis,17,High,1
Q562R1,Beta-actin-like protein 2 OS=Homo sapiens OX=9606 GN=ACTBL2 PE=1 SV=2,0,536.059,64,56,22998,8,376,42,5.59,13585175,2.21,56,3,,cytoplasm;cytoskeleton,nucleotide binding;protein binding,Pf00022,345651,ENSG00000169067.3,ACTBL2,5,,,,0,High,1
P13804,"Electron transfer flavoprotein subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=ETFA PE=1 SV=1",0,532.337,75,44,2793,44,333,35.1,8.38,1437470,152.45,40,9,metabolic process;transport,mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding,"Pf00766, Pf01012",2108,ENSG00000140374.15,ETFA,15,,,Respiratory electron transport,4,High,1
P27816,Microtubule-associated protein 4 OS=Homo sapiens OX=9606 GN=MAP4 PE=1 SV=3,0,531.354,54,61,1400,37,1152,120.9,5.43,664747,13.23,59,8,cell division;cell organization and biogenesis;cellular component movement;regulation of biological process,cytoplasm;cytoskeleton,protein binding;RNA binding;structural molecule activity,Pf00418,4134,ENSG00000047849.21,MAP4,3,,,,0,High,1
P36871,Phosphoglucomutase-1 OS=Homo sapiens OX=9606 GN=PGM1 PE=1 SV=3,0,531.278,80,47,2062,47,562,61.4,6.76,1053111,36.58,44,11,metabolic process;transport,cytoplasm;cytoskeleton;cytosol;extracellular,catalytic activity;metal ion binding;protein binding,"Pf00408, Pf02878, Pf02879, Pf02880",5236,ENSG00000079739.15,PGM1,1,Starch and sucrose metabolism; Amino sugar and nucleotide sugar metabolism; Purine metabolism; Pentose phosphate pathway; Galactose metabolism; Metabolic pathways; Glycolysis / Gluconeogenesis,Ectoderm Differentiation; Glycogen Metabolism; Glucuronidation,Neutrophil degranulation; Galactose catabolism; Glycogen breakdown (glycogenolysis); Glycogen synthesis; Defective PGM1 causes PGM1-CDG (CDG1t),23,High,1
P14923,Junction plakoglobin OS=Homo sapiens OX=9606 GN=JUP PE=1 SV=3,0,530.939,67,45,2021,41,745,81.7,6.14,1017145,187.29,36,17,cell death;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen,protein binding;signal transducer activity;structural molecule activity,Pf00514,3728,ENSG00000173801.16,JUP,17,Transcriptional misregulation in cancer; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Acute myeloid leukemia; Pathways in cancer,Arrhythmogenic Right Ventricular Cardiomyopathy; Corticotropin-releasing hormone signaling pathway; Ectoderm Differentiation,Adherens junctions interactions; Neutrophil degranulation; Formation of the cornified envelope; VEGFR2 mediated vascular permeability,22,High,1
P02675,Fibrinogen beta chain OS=Homo sapiens OX=9606 GN=FGB PE=1 SV=2,0,530.235,63,39,2175,39,491,55.9,8.27,1081334,35.05,36,8,cell organization and biogenesis;coagulation;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;extracellular;membrane;organelle lumen,protein binding;structural molecule activity,"Pf00147, Pf08702",2244,ENSG00000171564.11,FGB,4,Platelet activation; Complement and coagulation cascades,Blood Clotting Cascade; VEGFA-VEGFR2 Signaling Pathway; Complement and Coagulation Cascades,Integrin cell surface interactions; Signaling by BRAF and RAF fusions; MAP2K and MAPK activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; Platelet degranulation ; p130Cas linkage to MAPK signaling for integrins; Paradoxical activation of RAF signaling by kinase inactive BRAF; Common Pathway of Fibrin Clot Formation; Regulation of TLR by endogenous ligand; Interleukin-20 family signaling,38,High,1
P02787,Serotransferrin OS=Homo sapiens OX=9606 GN=TF PE=1 SV=3,0,529.979,53,51,2136,46,698,77,7.12,1013710,257.76,42,15,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;endosome;extracellular;membrane;organelle lumen,enzyme regulator activity;metal ion binding;protein binding;transporter activity,"Pf00405, Pf12974",7018,ENSG00000091513.14,TF,3,HIF-1 signaling pathway; Mineral absorption,Iron metabolism in placenta; Differentiation Pathway; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,Platelet degranulation ; Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Cargo recognition for clathrin-mediated endocytosis; Transferrin endocytosis and recycling,20,High,1
Q13509,Tubulin beta-3 chain OS=Homo sapiens OX=9606 GN=TUBB3 PE=1 SV=2,0,529.602,65,47,3453,7,450,50.4,4.93,1673728,62.39,45,10,cell organization and biogenesis;cellular component movement,cytoplasm;cytoskeleton;nucleus,catalytic activity;nucleotide binding;protein binding;structural molecule activity,"Pf00091, Pf03953, Pf10644",10381,ENSG00000258947.6,TUBB3,16,Pathogenic Escherichia coli infection; Phagosome; Gap junction,Pathogenic Escherichia coli infection; Parkin-Ubiquitin Proteasomal System pathway; Exercise-induced Circadian Regulation,COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Translocation of GLUT4 to the plasma membrane; Prefoldin mediated transfer of substrate  to CCT/TriC; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Separation of Sister Chromatids; COPI-mediated anterograde transport; HSP90 chaperone cycle for steroid hormone receptors (SHR); The role of GTSE1 in G2/M progression after G2 checkpoint; Kinesins; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; RHO GTPases Activate Formins; Post-chaperonin tubulin folding pathway; MHC class II antigen presentation,66,High,1
P08238,Heat shock protein HSP 90-beta OS=Homo sapiens OX=9606 GN=HSP90AB1 PE=1 SV=4,0,527.937,57,52,2269,26,724,83.2,5.03,1082142,12.14,50,13,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;cytosol;extracellular;membrane;mitochondrion;nucleus;organelle lumen,enzyme regulator activity;nucleotide binding;protein binding;RNA binding,"Pf00183, Pf02518, Pf13589",3326,ENSG00000096384.19,HSP90AB1,6,Pathways in cancer; Antigen processing and presentation; Protein processing in endoplasmic reticulum; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; PI3K-Akt signaling pathway; Prostate cancer; NOD-like receptor signaling pathway,NRF2 pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,Sema3A PAK dependent Axon repulsion; HSF1 activation; Attenuation phase; Neutrophil degranulation; Aryl hydrocarbon receptor signalling; Uptake and function of diphtheria toxin; Regulation of actin dynamics for phagocytic cup formation; The NLRP3 inflammasome; HSP90 chaperone cycle for steroid hormone receptors (SHR); The role of GTSE1 in G2/M progression after G2 checkpoint,42,High,1
Q9BUF5,Tubulin beta-6 chain OS=Homo sapiens OX=9606 GN=TUBB6 PE=1 SV=1,0,522.368,66,46,2934,13,446,49.8,4.88,1514823,6.28,46,5,cell organization and biogenesis,cytoplasm;cytoskeleton;nucleus,catalytic activity;nucleotide binding;structural molecule activity,"Pf00091, Pf03953, Pf10644",84617,ENSG00000176014.12,TUBB6,18,Phagosome; Pathogenic Escherichia coli infection; Gap junction,Pathogenic Escherichia coli infection; Parkin-Ubiquitin Proteasomal System pathway,COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Translocation of GLUT4 to the plasma membrane; Prefoldin mediated transfer of substrate  to CCT/TriC; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Separation of Sister Chromatids; COPI-mediated anterograde transport; HSP90 chaperone cycle for steroid hormone receptors (SHR); The role of GTSE1 in G2/M progression after G2 checkpoint; Kinesins; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; RHO GTPases Activate Formins; Post-chaperonin tubulin folding pathway; MHC class II antigen presentation,65,High,1
P07814,Bifunctional glutamate/proline--tRNA ligase OS=Homo sapiens OX=9606 GN=EPRS PE=1 SV=5,0,517.777,46,58,718,58,1512,170.5,7.33,325099,0,58,5,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding,"Pf00458, Pf00587, Pf00749, Pf01406, Pf03129, Pf03950, Pf09180, Pf14497",2058,ENSG00000136628.17,EPRS,1,Aminoacyl-tRNA biosynthesis; Metabolic pathways; Porphyrin and chlorophyll metabolism,Parkinsons Disease Pathway; Amino Acid metabolism,tRNA modification in the nucleus and cytosol; Cytosolic tRNA aminoacylation; SeMet incorporation into proteins,16,High,1
P00450,Ceruloplasmin OS=Homo sapiens OX=9606 GN=CP PE=1 SV=1,0,515.758,44,40,817,40,1065,122.1,5.72,380877,1.76,38,6,cellular homeostasis;metabolic process;transport,extracellular;membrane;organelle lumen,catalytic activity;metal ion binding;protein binding,"Pf00394, Pf07731, Pf07732",1356,,CP,3,Porphyrin and chlorophyll metabolism,,Metal ion SLC transporters; Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Iron uptake and transport; Defective CP causes aceruloplasminemia (ACERULOP),14,High,1
Q71U36,Tubulin alpha-1A chain OS=Homo sapiens OX=9606 GN=TUBA1A PE=1 SV=1,0,514.017,70,50,2508,1,451,50.1,5.06,1269794,56.31,48,8,cell division;cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;endosome;membrane;nucleus,catalytic activity;nucleotide binding;protein binding;structural molecule activity,"Pf00091, Pf03953",7846,ENSG00000167552.13,TUBA1A,12,Gap junction; Apoptosis; Phagosome; Pathogenic Escherichia coli infection,Pathogenic Escherichia coli infection; Parkin-Ubiquitin Proteasomal System pathway,COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Loss of Nlp from mitotic centrosomes; Translocation of GLUT4 to the plasma membrane; Prefoldin mediated transfer of substrate  to CCT/TriC; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Separation of Sister Chromatids; COPI-mediated anterograde transport; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR); Kinesins; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recruitment of mitotic centrosome proteins and complexes; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; Post-chaperonin tubulin folding pathway; RHO GTPases Activate Formins; MHC class II antigen presentation,73,High,1
Q13011,"Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial OS=Homo sapiens OX=9606 GN=ECH1 PE=1 SV=2",0,511.888,73,34,2640,34,328,35.8,8,1275434,610.49,33,5,metabolic process,membrane;mitochondrion,catalytic activity;protein binding,Pf00378,1891,ENSG00000282853.1; ENSG00000104823.8,ECH1,19; CHR_HG26_PATCH,Peroxisome,Fatty Acid Biosynthesis,,2,High,1
Q86TD4,Sarcalumenin OS=Homo sapiens OX=9606 GN=SRL PE=2 SV=2,0,508.715,40,40,2610,40,932,100.7,4.4,1251558,452.12,35,19,,endoplasmic reticulum;organelle lumen,nucleotide binding,"Pf00350, Pf01926",6345,,SRL,16,,,,0,High,1
P20674,"Cytochrome c oxidase subunit 5A, mitochondrial OS=Homo sapiens OX=9606 GN=COX5A PE=1 SV=2",0,504.534,67,41,3073,41,150,16.8,6.79,1526279,2.19,41,2,metabolic process;transport,membrane;mitochondrion,catalytic activity;metal ion binding;protein binding;transporter activity,Pf02284,9377,ENSG00000178741.11,COX5A,15,Cardiac muscle contraction; Parkinson's disease; Non-alcoholic fatty liver disease (NAFLD); Alzheimer's disease; Huntington's disease; Metabolic pathways; Oxidative phosphorylation,Electron Transport Chain; Arachidonate Epoxygenase / Epoxide Hydrolase,TP53 Regulates Metabolic Genes; Respiratory electron transport,18,High,1
P12236,ADP/ATP translocase 3 OS=Homo sapiens OX=9606 GN=SLC25A6 PE=1 SV=4,0,502.355,75,47,15446,6,298,32.8,9.74,8186814,536.16,43,14,cell death;cell organization and biogenesis;regulation of biological process;response to stimulus;transport,membrane;mitochondrion;nucleus,protein binding;transporter activity,Pf00153,293,ENSG00000169100.13,SLC25A6,X|Y; X,Influenza A; Huntington's disease; Parkinson's disease; cGMP-PKG signaling pathway; Calcium signaling pathway; HTLV-I infection,Electron Transport Chain,Mitochondrial protein import; Regulation of insulin secretion; Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization; Influenza Virus Induced Apoptosis; Metabolism of proteins,21,High,1
P09493-6,Isoform 6 of Tropomyosin alpha-1 chain OS=Homo sapiens OX=9606 GN=TPM1,0,501.164,71,48,9219,0,284,32.6,4.73,4999693,476.72,45,12,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cytoskeleton;cytosol,protein binding;structural molecule activity,"Pf00261, Pf12718",7168,,TPM1,15,,Striated Muscle Contraction,,1,Not Found,1
O95817,BAG family molecular chaperone regulator 3 OS=Homo sapiens OX=9606 GN=BAG3 PE=1 SV=3,0,501.164,77,38,1735,38,575,61.6,6.95,783847,67.04,34,9,cell death;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,enzyme regulator activity;nucleotide binding;protein binding,"Pf00397, Pf02179",9531,ENSG00000151929.9,BAG3,10,,,Regulation of HSF1-mediated heat shock response,4,High,1
O00159,Unconventional myosin-Ic OS=Homo sapiens OX=9606 GN=MYO1C PE=1 SV=4,0,499.594,53,53,1037,52,1063,121.6,9.41,507718,0,52,10,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus,catalytic activity;motor activity;nucleotide binding;protein binding,"Pf00063, Pf06017",4641,ENSG00000197879.14,MYO1C,17,,Insulin Signaling,Translocation of GLUT4 to the plasma membrane; Regulation of actin dynamics for phagocytic cup formation,8,High,1
P07900,Heat shock protein HSP 90-alpha OS=Homo sapiens OX=9606 GN=HSP90AA1 PE=1 SV=5,0,499.384,55,48,2761,21,732,84.6,5.02,1345511,15.94,47,12,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding;RNA binding,"Pf00183, Pf02518, Pf13589",3320,ENSG00000080824.18,HSP90AA1,14,Pathways in cancer; PI3K-Akt signaling pathway; Prostate cancer; NOD-like receptor signaling pathway; Estrogen signaling pathway; Antigen processing and presentation; Protein processing in endoplasmic reticulum; Progesterone-mediated oocyte maturation,Nucleotide-binding Oligomerization Domain (NOD) pathway; TNF alpha Signaling Pathway; Corticotropin-releasing hormone signaling pathway; Aryl Hydrocarbon Receptor; EBV LMP1 signaling; Aryl Hydrocarbon Receptor Pathway; Constitutive Androstane Receptor Pathway; NRF2 pathway; VEGFA-VEGFR2 Signaling Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,"Sema3A PAK dependent Axon repulsion; Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Scavenging by Class F Receptors; Neutrophil degranulation; Uptake and function of diphtheria toxin; Regulation of actin dynamics for phagocytic cup formation; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR); vRNP Assembly; Downregulation of ERBB2 signaling; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Constitutive Signaling by EGFRvIII; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; Recruitment of mitotic centrosome proteins and complexes; HSF1 activation; Attenuation phase; eNOS activation; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; VEGFR2 mediated vascular permeability; PIWI-interacting RNA (piRNA) biogenesis; Interleukin-4 and 13 signaling",86,High,1
P36776,"Lon protease homolog, mitochondrial OS=Homo sapiens OX=9606 GN=LONP1 PE=1 SV=2",0,499.176,52,41,1104,41,959,106.4,6.39,524853,8.42,39,4,cell organization and biogenesis;metabolic process;response to stimulus,cytosol;membrane;mitochondrion;nucleus;organelle lumen,catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding,"Pf00004, Pf00910, Pf01695, Pf02190, Pf05362, Pf05496, Pf07724, Pf07728, Pf08298, Pf13173, Pf13191, Pf13207, Pf13401, Pf13541",9361,ENSG00000196365.11,LONP1,19,,,,0,High,1
Q9BQE3,Tubulin alpha-1C chain OS=Homo sapiens OX=9606 GN=TUBA1C PE=1 SV=1,0,498.072,70,50,2729,5,449,49.9,5.1,1371637,14.34,50,7,cell division;cell organization and biogenesis;transport,cytoplasm;cytoskeleton;nucleus,catalytic activity;nucleotide binding;protein binding;structural molecule activity,"Pf00091, Pf03953",84790,ENSG00000167553.15,TUBA1C,12,Pathogenic Escherichia coli infection; Apoptosis; Gap junction; Phagosome,Pathogenic Escherichia coli infection; Parkin-Ubiquitin Proteasomal System pathway,COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Translocation of GLUT4 to the plasma membrane; Prefoldin mediated transfer of substrate  to CCT/TriC; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Separation of Sister Chromatids; COPI-mediated anterograde transport; HSP90 chaperone cycle for steroid hormone receptors (SHR); The role of GTSE1 in G2/M progression after G2 checkpoint; Kinesins; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; RHO GTPases Activate Formins; Post-chaperonin tubulin folding pathway; MHC class II antigen presentation,66,High,1
Q16698,"2,4-dienoyl-CoA reductase, mitochondrial OS=Homo sapiens OX=9606 GN=DECR1 PE=1 SV=1",0,497.249,73,39,4114,39,335,36,9.28,2037765,180.3,38,10,cell organization and biogenesis;metabolic process,cytosol;mitochondrion;nucleus;organelle lumen,catalytic activity;nucleotide binding,"Pf00106, Pf08659, Pf13561",1666,ENSG00000104325.6,DECR1,8,,Fatty Acid Beta Oxidation; Fatty Acid Biosynthesis,mitochondrial fatty acid beta-oxidation of unsaturated fatty acids,7,High,1
Q5T4S7,E3 ubiquitin-protein ligase UBR4 OS=Homo sapiens OX=9606 GN=UBR4 PE=1 SV=1,0,497.05,20,82,500,81,5183,573.5,6.04,226003,0,82,2,metabolic process;transport,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,catalytic activity;metal ion binding;protein binding,"Pf02207, Pf13764",23352,ENSG00000127481.14,UBR4,1,Viral carcinogenesis,,Neutrophil degranulation; Antigen processing: Ubiquitination & Proteasome degradation,7,High,1
O94875-7,Isoform 7 of Sorbin and SH3 domain-containing protein 2 OS=Homo sapiens OX=9606 GN=SORBS2,0,496.082,33,43,3008,0,1004,113.5,8.68,1468314,68.54,41,15,cell growth;cell organization and biogenesis,cytoskeleton;membrane;nucleus,protein binding;RNA binding;structural molecule activity,"Pf00018, Pf02208, Pf07653, Pf14604",8470,ENSG00000154556.17,SORBS2,4,,,,0,Not Found,1
P21796,Voltage-dependent anion-selective channel protein 1 OS=Homo sapiens OX=9606 GN=VDAC1 PE=1 SV=2,0,495.86,89,45,3446,41,283,30.8,8.54,1569789,157.4,41,10,cell communication;cell death;cell differentiation;defense response;metabolic process;regulation of biological process;response to stimulus;transport,membrane;mitochondrion;nucleus,protein binding;transporter activity,Pf01459,7416,ENSG00000213585.10,VDAC1,5,Calcium signaling pathway; cGMP-PKG signaling pathway; Parkinson's disease; Huntington's disease; NOD-like receptor signaling pathway; Influenza A; HTLV-I infection,,Mitochondrial calcium ion transport; Ub-specific processing proteases; Mitochondrial protein import; Pink/Parkin Mediated Mitophagy,16,High,1
Q96Q06-2,Isoform 2 of Perilipin-4 OS=Homo sapiens OX=9606 GN=PLIN4,0,495.434,50,40,868,40,1423,140.6,8.87,364135,242.22,34,20,,cytosol;membrane,,Pf03036,729359,,PLIN4,19,,,,0,High,1
P13637,Sodium/potassium-transporting ATPase subunit alpha-3 OS=Homo sapiens OX=9606 GN=ATP1A3 PE=1 SV=3,0,495.237,42,45,1525,21,1013,111.7,5.38,704766,130.95,41,10,cell communication;cellular homeostasis;regulation of biological process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;Golgi;membrane;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding;transporter activity,"Pf00122, Pf00689, Pf00690, Pf00702, Pf08282, Pf12710, Pf13246",478,ENSG00000105409.16,ATP1A3,19,Aldosterone-regulated sodium reabsorption; Insulin secretion; cGMP-PKG signaling pathway; Salivary secretion; Thyroid hormone synthesis; Proximal tubule bicarbonate reclamation; cAMP signaling pathway; Carbohydrate digestion and absorption; Endocrine and other factor-regulated calcium reabsorption; Pancreatic secretion; Bile secretion; Mineral absorption; Adrenergic signaling in cardiomyocytes; Cardiac muscle contraction; Thyroid hormone signaling pathway; Gastric acid secretion; Protein digestion and absorption,Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,Ion homeostasis; Ion transport by P-type ATPases,24,High,1
P46939,Utrophin OS=Homo sapiens OX=9606 GN=UTRN PE=1 SV=2,0,492.475,29,85,693,80,3433,394.2,5.33,303275,1.65,85,5,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;membrane,metal ion binding;protein binding,"Pf00307, Pf00397, Pf00435, Pf00569, Pf09068, Pf09069, Pf11971",7402,ENSG00000152818.18,UTRN,6,,Primary Focal Segmental Glomerulosclerosis FSGS,,1,High,1
P05141,ADP/ATP translocase 2 OS=Homo sapiens OX=9606 GN=SLC25A5 PE=1 SV=7,0,486.925,72,52,12393,12,298,32.8,9.69,6568098,27.65,46,17,regulation of biological process;transport,membrane;mitochondrion;nucleus,protein binding;RNA binding;transporter activity,Pf00153,292,ENSG00000005022.5,SLC25A5,X,Huntington's disease; Parkinson's disease; Calcium signaling pathway; HTLV-I infection; cGMP-PKG signaling pathway,Electron Transport Chain,Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization; Regulation of insulin secretion,15,High,1
Q07157,Tight junction protein ZO-1 OS=Homo sapiens OX=9606 GN=TJP1 PE=1 SV=3,0,485.023,48,58,573,57,1748,195.3,6.7,252205,0,58,2,cell communication;cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,protein binding,"Pf00018, Pf00595, Pf00625, Pf00791, Pf07653, Pf13180",7082,ENSG00000104067.16,TJP1,15,Gap junction; Vibrio cholerae infection; Salmonella infection; Tight junction; Epithelial cell signaling in Helicobacter pylori infection; Adherens junction,,c-src mediated regulation of Cx43 function and closure of gap junctions; Signaling by Hippo; RUNX1 regulates expression of components of tight junctions; Apoptotic cleavage of cell adhesion  proteins,23,High,1
P33121,Long-chain-fatty-acid--CoA ligase 1 OS=Homo sapiens OX=9606 GN=ACSL1 PE=1 SV=1,0,484.222,54,42,2806,38,698,77.9,7.15,1400516,77.26,37,14,metabolic process;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;membrane;mitochondrion,catalytic activity;nucleotide binding,Pf00501,2180,ENSG00000151726.13,ACSL1,4,PPAR signaling pathway; Adipocytokine signaling pathway; Peroxisome; Fatty acid biosynthesis; Fatty acid degradation; Fatty acid metabolism; Metabolic pathways,Fatty Acid Beta Oxidation; Fatty Acid Biosynthesis; Mitochondrial LC-Fatty Acid Beta-Oxidation; PPAR signaling pathway,Synthesis of very long-chain fatty acyl-CoAs; PPARA activates gene expression; Linoleic acid (LA) metabolism; alpha-linolenic acid (ALA) metabolism,21,High,1
Q96HC4,PDZ and LIM domain protein 5 OS=Homo sapiens OX=9606 GN=PDLIM5 PE=1 SV=5,0,483.395,46,44,2957,5,596,63.9,8.21,1446655,79.29,42,9,cell growth;regulation of biological process,cytoplasm;cytoskeleton;cytosol;membrane,metal ion binding;protein binding,"Pf00412, Pf00595, Pf13180",10611,ENSG00000163110.14,PDLIM5,4,,,Neurexins and neuroligins,3,High,1
P11310,"Medium-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADM PE=1 SV=1",0,482.611,63,40,4289,40,421,46.6,8.37,1946899,782.64,38,11,metabolic process;regulation of biological process,membrane;mitochondrion;nucleus;organelle lumen,catalytic activity;nucleotide binding;protein binding,"Pf00441, Pf02770, Pf02771, Pf08028, Pf11794",34,ENSG00000117054.13,ACADM,1,"Valine, leucine and isoleucine degradation; PPAR signaling pathway; Fatty acid degradation; Fatty acid metabolism; beta-Alanine metabolism; Propanoate metabolism; Metabolic pathways; Carbon metabolism",Fatty Acid Beta Oxidation; PPAR Alpha Pathway; Mitochondrial LC-Fatty Acid Beta-Oxidation; Amino Acid metabolism; PPAR signaling pathway; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,PPARA activates gene expression; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of octanoyl-CoA to hexanoyl-CoA,24,High,1
P35222,Catenin beta-1 OS=Homo sapiens OX=9606 GN=CTNNB1 PE=1 SV=1,0,480.408,61,36,1362,32,781,85.4,5.86,687621,55.88,30,11,cell communication;cell differentiation;cell growth;cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,DNA binding;protein binding;signal transducer activity,Pf00514,1499,ENSG00000168036.16,CTNNB1,3,Hippo signaling pathway; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy (ARVC); HTLV-I infection; Pathways in cancer; Thyroid cancer; Endometrial cancer; Adherens junction; Pathogenic Escherichia coli infection; Wnt signaling pathway; Thyroid hormone signaling pathway; Basal cell carcinoma; Colorectal cancer; Leukocyte transendothelial migration; Rap1 signaling pathway; Tight junction; Signaling pathways regulating pluripotency of stem cells; Bacterial invasion of epithelial cells; Proteoglycans in cancer; Melanogenesis; Prostate cancer; Breast cancer,Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Heart Development; TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway; Neural Crest Differentiation; Arrhythmogenic Right Ventricular Cardiomyopathy; Pathogenic Escherichia coli infection; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Gastric cancer network 2; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Primary Focal Segmental Glomerulosclerosis FSGS; Endoderm Differentiation; Ectoderm Differentiation; Extracellular vesicle-mediated signaling in recipient cells; Focal Adhesion; Rac1/Pak1/p38/MMP-2 pathway; Wnt Signaling Pathway Netpath; Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds; Association Between Physico-Chemical Features and Toxicity Associated Pathways; VEGFA-VEGFR2 Signaling Pathway; ESC Pluripotency Pathways; Wnt Signaling in Kidney Disease; H19 action Rb-E2F1 signaling and CDK-beta-catenin activity; Role of Osx and miRNAs in tooth development; Wnt Signaling Pathway and Pluripotency; Wnt Signaling Pathway; TGF-beta Receptor Signaling; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways; DNA Damage Response (only ATM dependent),"Beta-catenin phosphorylation cascade; CDO in myogenesis; Binding of TCF/LEF:CTNNB1 to target gene promoters; Apoptotic cleavage of cell adhesion  proteins; RUNX3 regulates WNT signaling; S37 mutants of beta-catenin aren't phosphorylated; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production; Ca2+ pathway; S33 mutants of beta-catenin aren't phosphorylated; Disassembly of the destruction complex and recruitment of AXIN to the membrane; S45 mutants of beta-catenin aren't phosphorylated; RHO GTPases activate IQGAPs; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Misspliced GSK3beta mutants stabilize beta-catenin; Adherens junctions interactions; Deactivation of the beta-catenin transactivating complex; InlA-mediated entry of Listeria monocytogenes into host cells; T41 mutants of beta-catenin aren't phosphorylated; VEGFR2 mediated vascular permeability",107,High,1
P30041,Peroxiredoxin-6 OS=Homo sapiens OX=9606 GN=PRDX6 PE=1 SV=3,0,479.644,82,44,2120,44,224,25,6.38,1090065,10.79,42,5,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen;vacuole,antioxidant activity;catalytic activity;protein binding,"Pf00578, Pf08534, Pf10417",9588,ENSG00000117592.8,PRDX6,1,Metabolic pathways,NRF2 pathway,Neutrophil degranulation; Detoxification of Reactive Oxygen Species,8,High,1
Q15124,Phosphoglucomutase-like protein 5 OS=Homo sapiens OX=9606 GN=PGM5 PE=1 SV=2,0,476.703,66,43,1804,43,567,62.2,7.21,886720,59.62,40,9,metabolic process,cytoplasm;cytoskeleton;cytosol;membrane,catalytic activity;metal ion binding;structural molecule activity,"Pf02878, Pf02879, Pf02880",5239,ENSG00000154330.12,PGM5,9,,Glucuronidation,,1,High,1
P07951-2,Isoform 2 of Tropomyosin beta chain OS=Homo sapiens OX=9606 GN=TPM2,0,476.291,51,41,5433,3,284,33,4.67,2903768,390.68,37,11,cell organization and biogenesis;cellular component movement;regulation of biological process,cytoskeleton;cytosol,protein binding;structural molecule activity,"Pf00261, Pf12718",7169,ENSG00000198467.13,TPM2,9,,Striated Muscle Contraction,,1,High,1
Q9NSE4,"Isoleucine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=IARS2 PE=1 SV=2",0,475.669,42,46,1578,46,1012,113.7,7.2,707868,23.96,44,9,metabolic process;regulation of biological process,cytoplasm;cytosol;mitochondrion;organelle lumen,catalytic activity;nucleotide binding;RNA binding,"Pf00133, Pf06827, Pf08264, Pf09334, Pf13603",55699,ENSG00000067704.9,IARS2,1,Aminoacyl-tRNA biosynthesis,,Mitochondrial tRNA aminoacylation,5,High,1
Q16555,Dihydropyrimidinase-related protein 2 OS=Homo sapiens OX=9606 GN=DPYSL2 PE=1 SV=1,0,474.293,66,33,1196,25,572,62.3,6.38,607540,54.76,30,9,cell differentiation;cell organization and biogenesis;cellular component movement;development;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane,catalytic activity;protein binding,"Pf01979, Pf07969, Pf13147, Pf13594",1808,ENSG00000092964.17,DPYSL2,8,Axon guidance,Regulation of Microtubule Cytoskeleton; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway,Recycling pathway of L1; CRMPs in Sema3A signaling,9,High,1
P01857,Immunoglobulin heavy constant gamma 1 OS=Homo sapiens OX=9606 GN=IGHG1 PE=1 SV=1,0,474.025,68,42,2341,7,330,36.1,8.19,1134206,285.63,38,9,cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity;metal ion binding;protein binding,"Pf07654, Pf08205",3500,ENSG00000277633.5; ENSG00000211896.7,IGHG1,14; CHR_HSCHR14_3_CTG1,,,Regulation of Complement cascade; Classical antibody-mediated complement activation; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Interleukin-4 and 13 signaling; Role of phospholipids in phagocytosis,14,High,1
P68366,Tubulin alpha-4A chain OS=Homo sapiens OX=9606 GN=TUBA4A PE=1 SV=1,0,473.812,67,47,2576,7,448,49.9,5.06,1288137,115.64,43,7,cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;extracellular,catalytic activity;nucleotide binding;protein binding;structural molecule activity,"Pf00091, Pf03953",7277,ENSG00000127824.13,TUBA4A,2,Phagosome; Pathogenic Escherichia coli infection; Apoptosis; Gap junction,Pathogenic Escherichia coli infection; Parkin-Ubiquitin Proteasomal System pathway,COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Loss of Nlp from mitotic centrosomes; Translocation of GLUT4 to the plasma membrane; Prefoldin mediated transfer of substrate  to CCT/TriC; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Separation of Sister Chromatids; COPI-mediated anterograde transport; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR); Kinesins; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recruitment of mitotic centrosome proteins and complexes; Recycling pathway of L1; Platelet degranulation ; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; Post-chaperonin tubulin folding pathway; RHO GTPases Activate Formins; MHC class II antigen presentation,76,High,1
P02549,"Spectrin alpha chain, erythrocytic 1 OS=Homo sapiens OX=9606 GN=SPTA1 PE=1 SV=5",0,473.802,37,67,477,66,2419,279.8,5.05,195185,0,67,5,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane,metal ion binding;protein binding;structural molecule activity,"Pf00018, Pf00435, Pf07653, Pf08726, Pf14604",6708,ENSG00000163554.12,SPTA1,1,Apoptosis,,Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interleukin-20 family signaling,22,High,1
P30101,Protein disulfide-isomerase A3 OS=Homo sapiens OX=9606 GN=PDIA3 PE=1 SV=4,0,471.864,64,39,1332,39,505,56.7,6.35,665726,2.53,38,5,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;endoplasmic reticulum;membrane;nucleus;organelle lumen,catalytic activity;protein binding;RNA binding,"Pf00085, Pf13098, Pf13848, Pf13899, Pf13905",2923,ENSG00000167004.12,PDIA3,15,Antigen processing and presentation; Protein processing in endoplasmic reticulum,,"ER-Phagosome pathway; Calnexin/calreticulin cycle; Antigen Presentation: Folding, assembly and peptide loading of class I MHC",13,High,1
Q5JRX3,"Presequence protease, mitochondrial OS=Homo sapiens OX=9606 GN=PITRM1 PE=1 SV=3",0,468.456,43,42,1039,42,1037,117.3,6.92,478103,4.98,41,4,metabolic process;regulation of biological process,mitochondrion;organelle lumen,catalytic activity;enzyme regulator activity;metal ion binding,"Pf00675, Pf05193, Pf08367",10531,ENSG00000107959.15,PITRM1,10,,,,0,High,1
P07951,Tropomyosin beta chain OS=Homo sapiens OX=9606 GN=TPM2 PE=1 SV=1,0,467.794,56,43,5512,4,284,32.8,4.7,3009791,46.03,41,9,cell organization and biogenesis;cellular component movement;regulation of biological process,cytoplasm;cytoskeleton;cytosol,protein binding;structural molecule activity,"Pf00261, Pf12718",7169,ENSG00000198467.13,TPM2,9,Dilated cardiomyopathy; Cardiac muscle contraction; Hypertrophic cardiomyopathy (HCM); Adrenergic signaling in cardiomyocytes,Striated Muscle Contraction,Smooth Muscle Contraction; Striated Muscle Contraction,8,High,1
P55786,Puromycin-sensitive aminopeptidase OS=Homo sapiens OX=9606 GN=NPEPPS PE=1 SV=2,0,467.612,52,46,1170,46,919,103.2,5.72,563162,6.3,45,8,metabolic process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding,"Pf01433, Pf11838, Pf13485",9520,ENSG00000141279.15,NPEPPS,17,,,Antigen processing: Ubiquitination & Proteasome degradation,4,High,1
P27338,Amine oxidase [flavin-containing] B OS=Homo sapiens OX=9606 GN=MAOB PE=1 SV=3,0,464.854,62,35,3180,33,520,58.7,7.5,1553390,87.18,34,8,metabolic process;regulation of biological process;response to stimulus,membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding,"Pf00070, Pf00890, Pf01266, Pf01494, Pf01593, Pf01946, Pf03486, Pf07992, Pf12831, Pf13450, Pf13738",4129,ENSG00000069535.13,MAOB,X,"Cocaine addiction; Amphetamine addiction; Tryptophan metabolism; Drug metabolism - cytochrome P450; Tyrosine metabolism; Alcoholism; Dopaminergic synapse; Phenylalanine metabolism; Histidine metabolism; Arginine and proline metabolism; Glycine, serine and threonine metabolism; Metabolic pathways; Serotonergic synapse",Dopamine metabolism; Tryptophan metabolism,Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB,20,High,1
Q14203-3,Isoform 3 of Dynactin subunit 1 OS=Homo sapiens OX=9606 GN=DCTN1,0,462.957,42,38,693,38,1236,136.7,5.4,333599,170.25,36,6,cell division;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport,chromosome;cytoplasm;cytoskeleton;cytosol;membrane,catalytic activity;motor activity;protein binding,"Pf00261, Pf01302, Pf04111, Pf05622, Pf05667, Pf06160, Pf08317, Pf12128, Pf12329, Pf12455, Pf13166, Pf13514, Pf15035",1639,ENSG00000204843.12,DCTN1,2,,,,0,High,1
Q13200,26S proteasome non-ATPase regulatory subunit 2 OS=Homo sapiens OX=9606 GN=PSMD2 PE=1 SV=3,0,461.443,48,42,837,42,908,100.1,5.2,410644,3.09,41,7,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen;proteasome,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding,Pf01851,5708,ENSG00000175166.16,PSMD2,3,Epstein-Barr virus infection; Proteasome,Proteasome Degradation; TNF alpha Signaling Pathway; Parkin-Ubiquitin Proteasomal System pathway,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Neutrophil degranulation; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,154,High,1
Q8N3V7,Synaptopodin OS=Homo sapiens OX=9606 GN=SYNPO PE=1 SV=2,0,460.843,47,39,1102,1,929,99.4,8.72,516038,37.05,37,8,regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;membrane;nucleus,protein binding,,11346,ENSG00000171992.12,SYNPO,5,,Primary Focal Segmental Glomerulosclerosis FSGS,,1,High,1
P24539,"ATP synthase F(0) complex subunit B1, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5PB PE=1 SV=2",0,460.742,79,34,3177,34,256,28.9,9.36,1661220,66.9,32,6,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion;nucleus;organelle lumen,catalytic activity;protein binding;transporter activity,Pf05405,515,ENSG00000116459.10,ATP5F1,1,Metabolic pathways; Parkinson's disease; Oxidative phosphorylation; Huntington's disease; Alzheimer's disease,Electron Transport Chain; Oxidative phosphorylation,Cristae formation; Formation of ATP by chemiosmotic coupling,14,High,1
P50993,Sodium/potassium-transporting ATPase subunit alpha-2 OS=Homo sapiens OX=9606 GN=ATP1A2 PE=1 SV=1,0,460.479,43,42,1303,23,1020,112.2,5.66,615382,88.52,40,9,cell communication;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;endosome;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding;transporter activity,"Pf00122, Pf00689, Pf00690, Pf00702, Pf08282, Pf12710, Pf13246",477,ENSG00000018625.14,ATP1A2,1,Endocrine and other factor-regulated calcium reabsorption; Gastric acid secretion; Pancreatic secretion; Insulin secretion; Protein digestion and absorption; Cardiac muscle contraction; Bile secretion; Carbohydrate digestion and absorption; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Mineral absorption; Salivary secretion; Aldosterone-regulated sodium reabsorption; Adrenergic signaling in cardiomyocytes; Proximal tubule bicarbonate reclamation; cGMP-PKG signaling pathway; cAMP signaling pathway,Synaptic Vesicle Pathway,Ion homeostasis; Ion transport by P-type ATPases,24,High,1
P40925-3,"Isoform 3 of Malate dehydrogenase, cytoplasmic OS=Homo sapiens OX=9606 GN=MDH1",0,460.122,61,42,3244,42,352,38.6,7.71,1586934,188.49,40,11,metabolic process,cytosol;mitochondrion,catalytic activity;nucleotide binding;protein binding,"Pf00056, Pf02866",4190,ENSG00000014641.17,MDH1,2,,Sterol Regulatory Element-Binding Proteins (SREBP) signalling; TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc); Amino Acid metabolism; Glycolysis and Gluconeogenesis,,4,High,1
Q8N3V7-2,Isoform 2 of Synaptopodin OS=Homo sapiens OX=9606 GN=SYNPO,0,459.759,47,39,1106,1,903,96.3,9.77,512420,65.47,36,9,regulation of biological process;response to stimulus,cytoskeleton;nucleus,protein binding,,11346,ENSG00000171992.12,SYNPO,5,,Primary Focal Segmental Glomerulosclerosis FSGS,,1,High,1
P15259,Phosphoglycerate mutase 2 OS=Homo sapiens OX=9606 GN=PGAM2 PE=1 SV=3,0,458.995,72,29,3438,11,253,28.7,8.88,1780100,398.48,26,10,metabolic process;regulation of biological process;response to stimulus,cytosol;nucleus,catalytic activity,Pf00300,5224,ENSG00000164708.5,PGAM2,7,"Glycine, serine and threonine metabolism; Biosynthesis of amino acids; Central carbon metabolism in cancer; Glucagon signaling pathway; Carbon metabolism; Metabolic pathways; Glycolysis / Gluconeogenesis",Glycolysis and Gluconeogenesis,Gluconeogenesis; Glycolysis,13,High,1
P11182,"Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DBT PE=1 SV=3",0,455.301,68,37,2283,36,482,53.5,8.51,1089549,85.29,34,10,metabolic process,mitochondrion;organelle lumen,catalytic activity;protein binding,"Pf00198, Pf00364, Pf02817",1629,,DBT,1,"Propanoate metabolism; Valine, leucine and isoleucine degradation; Metabolic pathways",,Branched-chain amino acid catabolism; Glyoxylate metabolism and glycine degradation,7,High,1
P16157,Ankyrin-1 OS=Homo sapiens OX=9606 GN=ANK1 PE=1 SV=3,0,454.75,40,58,624,47,1881,206.1,6.01,269618,0,57,5,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;nucleus,protein binding;structural molecule activity,"Pf00023, Pf00531, Pf00791, Pf12796, Pf13606, Pf13637, Pf13857",286,ENSG00000029534.19,ANK1,8,Proteoglycans in cancer,,CHL1 interactions; NrCAM interactions; Interaction between L1 and Ankyrins; Neurofascin interactions; COPI-mediated anterograde transport,16,High,1
P19022,Cadherin-2 OS=Homo sapiens OX=9606 GN=CDH2 PE=1 SV=4,0,453.915,40,33,1289,33,906,99.7,4.81,579155,178.36,29,12,cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process,cell surface;cytoplasm;cytoskeleton;membrane;organelle lumen,metal ion binding;protein binding,"Pf00028, Pf01049, Pf08758",1000,ENSG00000170558.8,CDH2,18,Cell adhesion molecules (CAMs); Arrhythmogenic right ventricular cardiomyopathy (ARVC),Neural Crest Differentiation; Arrhythmogenic Right Ventricular Cardiomyopathy; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Primary Focal Segmental Glomerulosclerosis FSGS,Adherens junctions interactions; Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); CDO in myogenesis,17,High,1
P08574,"Cytochrome c1, heme protein, mitochondrial OS=Homo sapiens OX=9606 GN=CYC1 PE=1 SV=3",0,453.67,61,36,1937,36,325,35.4,9,996551,242.58,32,7,metabolic process;response to stimulus;transport,membrane;mitochondrion;nucleus,metal ion binding,Pf02167,1537,ENSG00000179091.4,CYC1,8,Non-alcoholic fatty liver disease (NAFLD); Huntington's disease; Metabolic pathways; Parkinson's disease; Cardiac muscle contraction; Alzheimer's disease; Oxidative phosphorylation,,Respiratory electron transport; Mitochondrial protein import; Metabolism of proteins,13,High,1
P08559,"Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial OS=Homo sapiens OX=9606 GN=PDHA1 PE=1 SV=3",0,453.09,56,40,2570,39,390,43.3,8.06,1230910,43.28,39,7,metabolic process;regulation of biological process,mitochondrion;nucleus;organelle lumen,catalytic activity;protein binding,Pf00676,5160,ENSG00000131828.13,PDHA1,X,Pyruvate metabolism; HIF-1 signaling pathway; Glycolysis / Gluconeogenesis; Carbon metabolism; Citrate cycle (TCA cycle); Metabolic pathways; Glucagon signaling pathway; Central carbon metabolism in cancer,TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc); Amino Acid metabolism; Acetylcholine Synthesis; Glycolysis and Gluconeogenesis,Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Glyoxylate metabolism and glycine degradation,22,High,1
O95202,Mitochondrial proton/calcium exchanger protein OS=Homo sapiens OX=9606 GN=LETM1 PE=1 SV=1,0,452.67,50,37,766,37,739,83.3,6.7,372725,7.96,37,6,cell organization and biogenesis;cellular homeostasis;transport,membrane;mitochondrion,metal ion binding;protein binding;transporter activity,"Pf07766, Pf13833",3954,ENSG00000168924.14,LETM1,4,,,Mitochondrial calcium ion transport,2,High,1
P05023,Sodium/potassium-transporting ATPase subunit alpha-1 OS=Homo sapiens OX=9606 GN=ATP1A1 PE=1 SV=1,0,452.08,43,44,1401,23,1023,112.8,5.49,655663,42.91,42,4,cell communication;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;endosome;Golgi;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding;transporter activity,"Pf00122, Pf00689, Pf00690, Pf00702, Pf08282, Pf12710, Pf13246",476,ENSG00000163399.15,ATP1A1,1,Protein digestion and absorption; Cardiac muscle contraction; Aldosterone-regulated sodium reabsorption; Thyroid hormone signaling pathway; cGMP-PKG signaling pathway; Gastric acid secretion; Thyroid hormone synthesis; cAMP signaling pathway; Insulin secretion; Salivary secretion; Proximal tubule bicarbonate reclamation; Carbohydrate digestion and absorption; Endocrine and other factor-regulated calcium reabsorption; Pancreatic secretion; Bile secretion; Mineral absorption; Adrenergic signaling in cardiomyocytes,Preimplantation Embryo,Ion homeostasis; Ion transport by P-type ATPases,24,High,1
O15230,Laminin subunit alpha-5 OS=Homo sapiens OX=9606 GN=LAMA5 PE=1 SV=8,0,451.945,24,62,430,60,3695,399.5,7.02,185794,8.05,61,2,cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;regulation of biological process;response to stimulus;transport,extracellular;membrane;nucleus,catalytic activity;motor activity;protein binding;structural molecule activity,"Pf00052, Pf00053, Pf00054, Pf00055, Pf00529, Pf01576, Pf02210, Pf06008, Pf06009, Pf12795, Pf13514, Pf13747",3911,ENSG00000130702.15,LAMA5,20,Metabolic pathways; Pathways in cancer; Small cell lung cancer; Toxoplasmosis; Amoebiasis; PI3K-Akt signaling pathway; ECM-receptor interaction; Focal adhesion,Alpha 6 Beta 4 signaling pathway; Primary Focal Segmental Glomerulosclerosis FSGS; Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Inflammatory Response Pathway,ECM proteoglycans; Laminin interactions; Degradation of the extracellular matrix; MET activates PTK2 signaling; Interleukin-4 and 13 signaling; Non-integrin membrane-ECM interactions,27,High,1
P27824,Calnexin OS=Homo sapiens OX=9606 GN=CANX PE=1 SV=2,0,451.846,51,35,1791,35,592,67.5,4.6,889821,5.53,34,5,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;membrane;organelle lumen;ribosome,metal ion binding;protein binding;RNA binding,Pf00262,821,ENSG00000127022.14; ENSG00000283777.1,CANX,5; CHR_HG30_PATCH,Phagosome; Protein processing in endoplasmic reticulum; Thyroid hormone synthesis; HTLV-I infection; Antigen processing and presentation,,"Assembly of Viral Components at the Budding Site; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Interleukin-35 Signalling; Calnexin/calreticulin cycle; MHC class II antigen presentation",25,High,1
P10515,"Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DLAT PE=1 SV=3",0,449.666,56,34,2496,34,647,69,7.84,1174991,174.05,29,14,metabolic process;regulation of biological process,mitochondrion;organelle lumen,catalytic activity;protein binding,"Pf00198, Pf00364, Pf02817",1737,ENSG00000150768.15,DLAT,11,Glycolysis / Gluconeogenesis; Citrate cycle (TCA cycle); Metabolic pathways; Carbon metabolism; Pyruvate metabolism,TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc); Glycolysis and Gluconeogenesis,Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Glyoxylate metabolism and glycine degradation,17,High,1
Q709C8,Vacuolar protein sorting-associated protein 13C OS=Homo sapiens OX=9606 GN=VPS13C PE=1 SV=1,0,446.824,30,81,384,80,3753,422.1,6.83,151023,,81,,cell organization and biogenesis;transport,cytoplasm;cytosol;membrane;mitochondrion,,"Pf06650, Pf12624",54832,ENSG00000129003.15,VPS13C,15,,,,0,High,1
P07355,Annexin A2 OS=Homo sapiens OX=9606 GN=ANXA2 PE=1 SV=2,0,446.374,62,41,1932,41,339,38.6,7.75,960189,18.73,41,11,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;cytosol;endoplasmic reticulum;endosome;extracellular;membrane;nucleus;organelle lumen,enzyme regulator activity;metal ion binding;protein binding;RNA binding,Pf00191,302,ENSG00000182718.16,ANXA2,15,,Prostaglandin Synthesis and Regulation,Dissolution of Fibrin Clot; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Smooth Muscle Contraction; Neutrophil degranulation; Interleukin-12 family signaling,12,High,1
P20810,Calpastatin OS=Homo sapiens OX=9606 GN=CAST PE=1 SV=4,0,446.299,59,38,1026,38,708,76.5,5.07,464622,59.86,32,8,regulation of biological process,cytosol;endoplasmic reticulum;membrane,enzyme regulator activity;protein binding;RNA binding,Pf00748,831,ENSG00000153113.23,CAST,5,,,Degradation of the extracellular matrix; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models,5,High,1
Q07954,Prolow-density lipoprotein receptor-related protein 1 OS=Homo sapiens OX=9606 GN=LRP1 PE=1 SV=2,0,443.541,20,67,477,67,4544,504.3,5.39,198852,0,67,3,cell proliferation;development;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane;nucleus,metal ion binding;protein binding;receptor activity;RNA binding;transporter activity,"Pf00057, Pf00058, Pf07645, Pf12662, Pf14670",4035,ENSG00000123384.13,LRP1,12,Malaria; Alzheimer's disease,Alzheimers Disease; Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds; Statin Pathway,Signaling by GPCR; Scavenging of heme from plasma; Retinoid metabolism and transport,15,High,1
Q9H987-2,Isoform 2 of Synaptopodin 2-like protein OS=Homo sapiens OX=9606 GN=SYNPO2L,0,443.447,63,34,1656,1,753,79.1,9.77,846824,248.51,27,15,regulation of biological process,cytoskeleton;cytosol;nucleus,protein binding,,79933,ENSG00000166317.11,SYNPO2L,10,,,,0,High,1
P35221,Catenin alpha-1 OS=Homo sapiens OX=9606 GN=CTNNA1 PE=1 SV=1,0,442.088,54,41,1369,40,906,100,6.29,652439,11.87,39,7,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;Golgi;membrane,protein binding;RNA binding;structural molecule activity,Pf01044,1495,ENSG00000044115.20,CTNNA1,5,Leukocyte transendothelial migration; Hippo signaling pathway; Pathways in cancer; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Bacterial invasion of epithelial cells; Adherens junction; Endometrial cancer; Tight junction,Arrhythmogenic Right Ventricular Cardiomyopathy; Apoptosis-related network due to altered Notch3 in ovarian cancer; VEGFA-VEGFR2 Signaling Pathway; White fat cell differentiation,Adherens junctions interactions; CDO in myogenesis; VEGFR2 mediated vascular permeability; RHO GTPases activate IQGAPs,27,High,1
Q86UP2,Kinectin OS=Homo sapiens OX=9606 GN=KTN1 PE=1 SV=1,0,441.989,47,58,453,58,1357,156.2,5.64,215513,3.14,57,1,cellular component movement;metabolic process,endoplasmic reticulum;membrane;organelle lumen,protein binding;RNA binding,,3895,ENSG00000126777.17,KTN1,14,,,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); RHO GTPases activate KTN1,8,High,1
Q8WWI1,LIM domain only protein 7 OS=Homo sapiens OX=9606 GN=LMO7 PE=1 SV=3,0,441.582,37,53,591,7,1683,192.6,8.09,268063,71.29,47,10,metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;protein binding,"Pf00307, Pf00412, Pf00595, Pf13180",4008,,LMO7,13,Adherens junction,,Antigen processing: Ubiquitination & Proteasome degradation; Neddylation,8,High,1
P07237,Protein disulfide-isomerase OS=Homo sapiens OX=9606 GN=P4HB PE=1 SV=3,0,439.682,63,43,1850,43,508,57.1,4.87,957082,5.6,43,6,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;extracellular;membrane;organelle lumen,catalytic activity;metal ion binding;protein binding;RNA binding,"Pf00085, Pf01216, Pf13098, Pf13848, Pf13899, Pf13905",5034,ENSG00000185624.14,P4HB,17,Protein processing in endoplasmic reticulum,,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); VLDL assembly; Chylomicron assembly; Collagen biosynthesis and modifying enzymes; Interleukin-12 family signaling; Detoxification of Reactive Oxygen Species; Hedgehog ligand biogenesis,23,High,1
P09493-7,Isoform 7 of Tropomyosin alpha-1 chain OS=Homo sapiens OX=9606 GN=TPM1,0,439.538,67,42,8345,1,284,32.7,4.74,4509255,474.05,38,11,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cytoskeleton;cytosol,protein binding;structural molecule activity,Pf00261,7168,ENSG00000140416.19,TPM1,15,,Striated Muscle Contraction,,1,High,1
P13807,"Glycogen [starch] synthase, muscle OS=Homo sapiens OX=9606 GN=GYS1 PE=1 SV=2",0,438.771,46,34,1461,33,737,83.7,6.18,698229,68.2,33,10,metabolic process,cytoplasm;cytosol;membrane,catalytic activity;protein binding,"Pf00534, Pf05693, Pf13579",2997,ENSG00000104812.14,GYS1,19,AMPK signaling pathway; PI3K-Akt signaling pathway; Glucagon signaling pathway; Metabolic pathways; Starch and sucrose metabolism; Insulin signaling pathway; Insulin resistance,AMP-activated Protein Kinase (AMPK) Signaling; Angiopoietin Like Protein 8 Regulatory Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Insulin Signaling; Glycogen Metabolism,Glycogen storage disease type IV (GBE1); Glycogen storage disease type XV (GYG1); Glycogen storage disease type 0 (muscle GYS1); Glycogen synthesis; Myoclonic epilepsy of Lafora,24,High,1
Q16134,"Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial OS=Homo sapiens OX=9606 GN=ETFDH PE=1 SV=2",0,438.683,67,36,1538,36,617,68.5,7.55,727407,209.49,29,10,metabolic process;response to stimulus;transport,membrane;mitochondrion;organelle lumen,catalytic activity;metal ion binding;nucleotide binding,"Pf00890, Pf01266, Pf01494, Pf01946, Pf03486, Pf05187, Pf05834, Pf07992, Pf12831, Pf12838, Pf13450, Pf13454, Pf13738",2110,ENSG00000171503.11,ETFDH,4,,,Respiratory electron transport,4,High,1
Q08043,Alpha-actinin-3 OS=Homo sapiens OX=9606 GN=ACTN3 PE=1 SV=2,0,438.152,26,40,2845,3,901,103.2,5.52,1537565,236.92,36,12,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cytosol,metal ion binding;protein binding;structural molecule activity,"Pf00307, Pf00435, Pf08726, Pf11971, Pf13499",89,ENSG00000248746.5,ACTN3,11,Viral carcinogenesis; Leukocyte transendothelial migration; Tight junction; Adherens junction; Amoebiasis; Systemic lupus erythematosus; Regulation of actin cytoskeleton; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy (ARVC),Arrhythmogenic Right Ventricular Cardiomyopathy; Striated Muscle Contraction,Nephrin family interactions; Striated Muscle Contraction,15,High,1
A5A3E0,POTE ankyrin domain family member F OS=Homo sapiens OX=9606 GN=POTEF PE=1 SV=2,0,437.707,15,48,25756,1,1075,121.4,6.2,14182615,5.71,48,5,,cytoplasm,protein binding,"Pf00022, Pf00023, Pf12796, Pf13606, Pf13637, Pf13857, Pf14915",728378,ENSG00000196604.12,POTEF,2,,,,0,High,1
P49821,"NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFV1 PE=1 SV=4",0,437.292,57,33,2763,33,464,50.8,8.21,1352969,219.83,27,11,cell organization and biogenesis;metabolic process;transport,cytosol;membrane;mitochondrion,catalytic activity;metal ion binding;nucleotide binding,"Pf01512, Pf10531, Pf10589",4723,ENSG00000167792.11,NDUFV1,11,Huntington's disease; Metabolic pathways; Alzheimer's disease; Non-alcoholic fatty liver disease (NAFLD); Parkinson's disease; Oxidative phosphorylation,Electron Transport Chain; Oxidative phosphorylation,Complex I biogenesis,13,High,1
P18669,Phosphoglycerate mutase 1 OS=Homo sapiens OX=9606 GN=PGAM1 PE=1 SV=2,0,436.254,72,31,2979,9,254,28.8,7.18,1643229,8.34,30,5,metabolic process;regulation of biological process;transport,cytoplasm;cytosol;extracellular;membrane;organelle lumen,catalytic activity;protein binding,Pf00300,5223; 643576,ENSG00000171314.8,PGAM1; LOC643576,10; 12,"Glucagon signaling pathway; Central carbon metabolism in cancer; Biosynthesis of amino acids; Glycine, serine and threonine metabolism; Metabolic pathways; Glycolysis / Gluconeogenesis; Carbon metabolism",Cori Cycle; Glycolysis and Gluconeogenesis,Gluconeogenesis; Glycolysis; Neutrophil degranulation,17,High,1
O00429,Dynamin-1-like protein OS=Homo sapiens OX=9606 GN=DNM1L PE=1 SV=2,0,433.916,60,38,845,38,736,81.8,6.81,402304,8.19,38,4,cell death;cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;Golgi;membrane;mitochondrion,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding,"Pf00350, Pf01031, Pf02212",10059,ENSG00000087470.17,DNM1L,12,TNF signaling pathway; NOD-like receptor signaling pathway,Synaptic Vesicle Pathway,Apoptotic execution  phase,6,High,1
Q9Y4W6,AFG3-like protein 2 OS=Homo sapiens OX=9606 GN=AFG3L2 PE=1 SV=2,0,433.786,53,46,1397,45,797,88.5,8.66,664235,90.49,42,9,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,membrane;mitochondrion,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00004, Pf01078, Pf01434, Pf05496, Pf06068, Pf06480, Pf07724, Pf07728, Pf13191, Pf13401",10939,ENSG00000141385.9,AFG3L2,18,,,Processing of SMDT1,3,High,1
P26038,Moesin OS=Homo sapiens OX=9606 GN=MSN PE=1 SV=3,0,431.639,53,37,2001,23,577,67.8,6.4,1012051,1.82,37,7,cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;regulation of biological process;response to stimulus,cell surface;cytoplasm;cytoskeleton;cytosol;membrane;nucleus,protein binding;RNA binding;structural molecule activity,"Pf00373, Pf00769, Pf09379, Pf09380",4478,ENSG00000147065.16,MSN,X,Regulation of actin cytoskeleton; Leukocyte transendothelial migration; Measles; Proteoglycans in cancer,Glial Cell Differentiation; AGE/RAGE pathway; Regulation of Actin Cytoskeleton,Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Interleukin-12 family signaling; Recycling pathway of L1,16,High,1
P12109,Collagen alpha-1(VI) chain OS=Homo sapiens OX=9606 GN=COL6A1 PE=1 SV=3,0,430.15,28,39,1215,39,1028,108.5,5.43,621641,28.61,38,5,cell differentiation;cell organization and biogenesis;metabolic process;response to stimulus,extracellular;membrane;organelle lumen,protein binding,"Pf00092, Pf01391, Pf13519",1291,ENSG00000142156.14,COL6A1,21,Protein digestion and absorption; PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction,miRNA targets in ECM and membrane receptors,ECM proteoglycans; Collagen degradation; Integrin cell surface interactions; Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization; NCAM1 interactions; Signaling by PDGF,21,High,1
Q5VWP3-3,Isoform 3 of Muscular LMNA-interacting protein OS=Homo sapiens OX=9606 GN=MLIP,0,429.524,45,33,723,2,993,105.8,8.06,232234,817.46,15,25,regulation of biological process,membrane;nucleus;organelle lumen,,Pf15274,90523,ENSG00000146147.14,MLIP,6,,,,0,High,1
Q00325,"Phosphate carrier protein, mitochondrial OS=Homo sapiens OX=9606 GN=SLC25A3 PE=1 SV=2",0,427.958,53,39,5197,39,362,40.1,9.38,2691390,68.24,38,10,transport,membrane;mitochondrion,protein binding;transporter activity,Pf00153,5250,ENSG00000075415.12,SLC25A3,12,,,,0,High,1
P48047,"ATP synthase subunit O, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5PO PE=1 SV=1",0,427.059,72,41,4442,41,213,23.3,9.96,2174642,945.39,39,9,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion;nucleus,catalytic activity;protein binding;transporter activity,Pf00213,539,ENSG00000241837.6,ATP5O,21,Metabolic pathways; Alzheimer's disease; Huntington's disease; Oxidative phosphorylation; Parkinson's disease,Electron Transport Chain; Oxidative phosphorylation,Cristae formation; Formation of ATP by chemiosmotic coupling,14,High,1
P00338,L-lactate dehydrogenase A chain OS=Homo sapiens OX=9606 GN=LDHA PE=1 SV=2,0,426.873,72,42,1713,38,332,36.7,8.27,848234,174.37,42,5,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00056, Pf02866",3939,ENSG00000134333.13,LDHA,11,Central carbon metabolism in cancer; Cysteine and methionine metabolism; Glucagon signaling pathway; HIF-1 signaling pathway; Metabolic pathways; Pyruvate metabolism; Propanoate metabolism; Glycolysis / Gluconeogenesis,Cori Cycle; Photodynamic therapy-induced HIF-1 survival signaling; Amino Acid metabolism; Glycolysis and Gluconeogenesis,Pyruvate metabolism,16,High,1
P19367,Hexokinase-1 OS=Homo sapiens OX=9606 GN=HK1 PE=1 SV=3,0,425.941,44,44,2333,37,917,102.4,6.8,1170401,43.41,40,14,cellular homeostasis;metabolic process;regulation of biological process,cytosol;membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding,"Pf00349, Pf03727",3098,ENSG00000156515.21,HK1,10,"Neomycin, kanamycin and gentamicin biosynthesis; HIF-1 signaling pathway; Fructose and mannose metabolism; Galactose metabolism; Amino sugar and nucleotide sugar metabolism; Central carbon metabolism in cancer; Glycolysis / Gluconeogenesis; Insulin signaling pathway; Starch and sucrose metabolism; Type II diabetes mellitus; Metabolic pathways; Carbon metabolism; Carbohydrate digestion and absorption",Cori Cycle; Photodynamic therapy-induced HIF-1 survival signaling; Glycolysis and Gluconeogenesis; Glucuronidation,Glycolysis; Defective HK1 causes hexokinase deficiency (HK deficiency),25,High,1
Q96RQ3,"Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=MCCC1 PE=1 SV=3",0,424.055,50,30,828,29,725,80.4,7.78,401941,38.93,27,8,cell organization and biogenesis;metabolic process,cytosol;membrane;mitochondrion;organelle lumen,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00289, Pf00364, Pf01071, Pf02222, Pf02655, Pf02785, Pf02786, Pf07478, Pf08443, Pf13533, Pf13535, Pf15632",56922,ENSG00000078070.12,MCCC1,3,"Metabolic pathways; Valine, leucine and isoleucine degradation",Amino Acid metabolism,Branched-chain amino acid catabolism; Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency,14,High,1
Q92614,Unconventional myosin-XVIIIa OS=Homo sapiens OX=9606 GN=MYO18A PE=1 SV=3,0,422.649,29,54,507,54,2054,233,6.3,235065,10.58,54,3,cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport,cell surface;cytoplasm;cytoskeleton;Golgi;membrane,catalytic activity;DNA binding;motor activity;nucleotide binding;protein binding;RNA binding;structural molecule activity;transporter activity,"Pf00038, Pf00063, Pf00595, Pf00769, Pf01496, Pf01576, Pf02463, Pf02841, Pf03962, Pf04111, Pf04156, Pf04502, Pf04615, Pf05483, Pf05557, Pf05622, Pf05701, Pf05911, Pf06008, Pf06160, Pf06785, Pf06818, Pf07111, Pf07888, Pf08286, Pf09726, Pf09728, Pf09731, Pf09789, Pf10174, Pf12128, Pf12252, Pf12718, Pf13514, Pf13851, Pf14643, Pf14662, Pf14992, Pf15066, Pf15070, Pf15397",399687,ENSG00000196535.15,MYO18A,17,,,Signaling by cytosolic FGFR1 fusion mutants,6,High,1
Q8WWI1-3,Isoform 3 of LIM domain only protein 7 OS=Homo sapiens OX=9606 GN=LMO7,0,422.175,41,47,570,1,1349,153.6,7.75,266709,18.46,46,5,metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;protein binding,"Pf00307, Pf00412, Pf00595, Pf13180",4008,ENSG00000136153.19,LMO7,13,,,,0,High,1
Q16851,UTP--glucose-1-phosphate uridylyltransferase OS=Homo sapiens OX=9606 GN=UGP2 PE=1 SV=5,0,421.959,63,39,1700,3,508,56.9,8.15,841170,32.86,38,6,metabolic process,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,Pf01704,7360,ENSG00000169764.15,UGP2,2,Starch and sucrose metabolism; Pentose and glucuronate interconversions; Metabolic pathways; Amino sugar and nucleotide sugar metabolism; Galactose metabolism,Exercise-induced Circadian Regulation; Glycogen Metabolism; Glucuronidation,"Formation of the active cofactor, UDP-glucuronate; Glycogen synthesis",16,High,1
P02647,Apolipoprotein A-I OS=Homo sapiens OX=9606 GN=APOA1 PE=1 SV=1,0,421.239,75,41,1776,41,267,30.8,5.76,889423,2.07,41,4,cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytosol;endosome;extracellular;membrane;nucleus;organelle lumen,enzyme regulator activity;protein binding;transporter activity,Pf01442,335,ENSG00000118137.9,APOA1,11,African trypanosomiasis; Fat digestion and absorption; PPAR signaling pathway; Vitamin digestion and absorption,Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism; PPAR Alpha Pathway; PPAR signaling pathway; Statin Pathway,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Amyloid fiber formation; Scavenging of heme from plasma; Retinoid metabolism and transport; Chylomicron remodeling; HDL assembly; ABC transporters in lipid homeostasis; PPARA activates gene expression; Scavenging by Class A Receptors; Signaling by GPCR; Platelet degranulation ; Scavenging by Class B Receptors; HDL remodeling; HDL clearance; Chylomicron assembly,46,High,1
Q5VWP3-4,Isoform 4 of Muscular LMNA-interacting protein OS=Homo sapiens OX=9606 GN=MLIP,0,418.967,48,33,734,2,915,97.5,8.62,243271,757.32,17,23,regulation of biological process,membrane;nucleus;organelle lumen,,Pf15274,90523,ENSG00000146147.14,MLIP,6,,,,0,High,1
P60174-1,Isoform 2 of Triosephosphate isomerase OS=Homo sapiens OX=9606 GN=TPI1,0,418.173,91,35,2524,35,249,26.7,6.9,1240062,230.41,31,10,development;metabolic process,cytosol;nucleus,catalytic activity;protein binding,Pf00121,7167,ENSG00000111669.14,TPI1,12,,Fatty Acid Beta Oxidation; Cori Cycle; Glycolysis and Gluconeogenesis,,3,High,1
P54652,Heat shock-related 70 kDa protein 2 OS=Homo sapiens OX=9606 GN=HSPA2 PE=1 SV=1,0,418.004,54,44,1504,15,639,70,5.74,746081,2.64,44,3,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cell surface;cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus,nucleotide binding;protein binding,"Pf00012, Pf06723",3306,ENSG00000126803.9,HSPA2,14,MAPK signaling pathway; Longevity regulating pathway - multiple species; Estrogen signaling pathway; Toxoplasmosis; Spliceosome; Endocytosis; Legionellosis; Measles; Antigen processing and presentation; Influenza A; Protein processing in endoplasmic reticulum; Epstein-Barr virus infection,Parkin-Ubiquitin Proteasomal System pathway,Meiotic synapsis; Attenuation phase; HSP90 chaperone cycle for steroid hormone receptors (SHR); Regulation of HSF1-mediated heat shock response,24,High,1
Q14624,Inter-alpha-trypsin inhibitor heavy chain H4 OS=Homo sapiens OX=9606 GN=ITIH4 PE=1 SV=4,0,416.924,45,37,711,37,930,103.3,6.98,335212,8.16,37,4,defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;extracellular;membrane;organelle lumen,enzyme regulator activity;protein binding,"Pf00092, Pf06668, Pf08487, Pf10138, Pf13444, Pf13519, Pf13768",3700,ENSG00000055955.15,ITIH4,3,,,Platelet degranulation,4,High,1
P01011,Alpha-1-antichymotrypsin OS=Homo sapiens OX=9606 GN=SERPINA3 PE=1 SV=2,0,415.309,64,32,1617,31,423,47.6,5.52,799047,14.49,32,7,defense response;regulation of biological process;response to stimulus;transport,extracellular;nucleus;organelle lumen,DNA binding;enzyme regulator activity;protein binding,Pf00079,12,ENSG00000196136.17,SERPINA3,14,,Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism,Platelet degranulation ; Neutrophil degranulation,10,High,1
P0CG38,POTE ankyrin domain family member I OS=Homo sapiens OX=9606 GN=POTEI PE=3 SV=1,0,412.118,16,47,24702,3,1075,121.2,6.21,13584387,121.18,46,6,,,protein binding,"Pf00022, Pf00023, Pf12796, Pf13606, Pf13637, Pf13857, Pf14915",653269,ENSG00000196834.11,POTEI,2,,,,0,High,1
P30048,"Thioredoxin-dependent peroxide reductase, mitochondrial OS=Homo sapiens OX=9606 GN=PRDX3 PE=1 SV=3",0,409.948,64,37,2684,35,256,27.7,7.78,1426708,208.68,35,4,cell death;cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endosome;mitochondrion;organelle lumen,antioxidant activity;catalytic activity;enzyme regulator activity;protein binding,"Pf00578, Pf08534, Pf10417, Pf13905",10935,ENSG00000165672.6,PRDX3,10,,Selenium Micronutrient Network,Detoxification of Reactive Oxygen Species,4,High,1
Q02978,Mitochondrial 2-oxoglutarate/malate carrier protein OS=Homo sapiens OX=9606 GN=SLC25A11 PE=1 SV=3,0,409.253,74,31,2938,31,314,34,9.91,1522181,6.2,31,9,metabolic process;transport,membrane;mitochondrion;nucleus,RNA binding;transporter activity,Pf00153,8402,ENSG00000108528.13,SLC25A11,17,,,Gluconeogenesis,4,High,1
Q16851-2,Isoform 2 of UTP--glucose-1-phosphate uridylyltransferase OS=Homo sapiens OX=9606 GN=UGP2,0,405.432,63,38,1586,2,497,55.6,7.88,768562,71.79,35,8,metabolic process,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,Pf01704,7360,ENSG00000169764.15,UGP2,2,,Exercise-induced Circadian Regulation; Glycogen Metabolism; Glucuronidation,,3,High,1
P00367,"Glutamate dehydrogenase 1, mitochondrial OS=Homo sapiens OX=9606 GN=GLUD1 PE=1 SV=2",0,404.848,64,42,1658,42,558,61.4,7.8,822387,37.31,38,7,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding,"Pf00208, Pf02812",2746,ENSG00000148672.8,GLUD1,10,"D-Glutamine and D-glutamate metabolism; Alanine, aspartate and glutamate metabolism; Arginine biosynthesis; Nitrogen metabolism; Carbon metabolism; Metabolic pathways; Proximal tubule bicarbonate reclamation",Amino Acid metabolism; Urea cycle and metabolism of amino groups,Transcriptional activation of mitochondrial biogenesis; Amino acid synthesis and interconversion (transamination),15,High,1
P23327,Sarcoplasmic reticulum histidine-rich calcium-binding protein OS=Homo sapiens OX=9606 GN=HRC PE=1 SV=1,0,404.55,41,24,1084,24,699,80.2,4.72,486456,264.53,21,11,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;membrane;organelle lumen,metal ion binding;protein binding,,3270,ENSG00000130528.11,HRC,19,,,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs),4,High,1
P78371,T-complex protein 1 subunit beta OS=Homo sapiens OX=9606 GN=CCT2 PE=1 SV=4,0,404.507,66,31,837,31,535,57.5,6.46,402606,9.49,30,6,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;extracellular;organelle lumen,nucleotide binding;protein binding,Pf00118,10576,ENSG00000166226.12,CCT2,12,,,BBSome-mediated cargo-targeting to cilium; Prefoldin mediated transfer of substrate  to CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Neutrophil degranulation; Folding of actin by CCT/TriC; Formation of tubulin folding intermediates by CCT/TriC,16,High,1
Q9H4M9,EH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=EHD1 PE=1 SV=2,0,404.423,74,37,1109,23,534,60.6,6.83,527655,0,37,3,cell organization and biogenesis;coagulation;regulation of biological process;response to stimulus;transport,endosome;membrane,metal ion binding;nucleotide binding;protein binding,"Pf00350, Pf01926, Pf12763",10938,ENSG00000110047.17,EHD1,11,Endocytosis,Insulin Signaling,Factors involved in megakaryocyte development and platelet production,4,High,1
O75112-3,Isoform 3 of LIM domain-binding protein 3 OS=Homo sapiens OX=9606 GN=LDB3,0,403.92,53,28,4343,1,470,50.6,8.32,1970105,188.15,24,9,cell organization and biogenesis,cytoskeleton,metal ion binding;protein binding,"Pf00412, Pf00595",11155,,LDB3,10,,,,0,High,1
Q04446,"1,4-alpha-glucan-branching enzyme OS=Homo sapiens OX=9606 GN=GBE1 PE=1 SV=3",0,402.639,51,37,1085,37,702,80.4,6.32,475340,57.67,35,9,metabolic process,cytosol,catalytic activity;protein binding,"Pf00128, Pf02806, Pf02922",2632,ENSG00000114480.12,GBE1,3,Metabolic pathways; Starch and sucrose metabolism,Glycogen Metabolism,Glycogen storage disease type IV (GBE1); Glycogen synthesis,12,High,1
P49419-2,Isoform 2 of Alpha-aminoadipic semialdehyde dehydrogenase OS=Homo sapiens OX=9606 GN=ALDH7A1,0,400.761,58,29,885,29,511,55.3,6.86,423492,38.5,28,7,metabolic process,cytosol;mitochondrion;nucleus;organelle lumen,catalytic activity;protein binding,Pf00171,501,,ALDH7A1,5,,,,0,High,1
Q9NY65,Tubulin alpha-8 chain OS=Homo sapiens OX=9606 GN=TUBA8 PE=1 SV=1,0,400.565,63,38,1914,8,449,50.1,5.06,924799,100.58,35,9,cell organization and biogenesis;metabolic process,cytoplasm;cytoskeleton;cytosol;mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding;structural molecule activity,"Pf00091, Pf03953",51807; 1962,ENSG00000183785.14,TUBA8; EHHADH,22; 3,Pathogenic Escherichia coli infection; Phagosome; Apoptosis; Gap junction,Pathogenic Escherichia coli infection; Parkin-Ubiquitin Proteasomal System pathway; Mitochondrial LC-Fatty Acid Beta-Oxidation,COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Cilium Assembly; Recruitment of NuMA to mitotic centrosomes; Translocation of GLUT4 to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Separation of Sister Chromatids; COPI-mediated anterograde transport; HSP90 chaperone cycle for steroid hormone receptors (SHR); The role of GTSE1 in G2/M progression after G2 checkpoint; Kinesins; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; Post-chaperonin tubulin folding pathway; MHC class II antigen presentation,63,High,1
P11177,"Pyruvate dehydrogenase E1 component subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=PDHB PE=1 SV=3",0,400.174,64,29,2634,29,359,39.2,6.65,1338574,77.91,27,10,metabolic process;regulation of biological process,mitochondrion;nucleus;organelle lumen,catalytic activity;protein binding,"Pf02779, Pf02780",5162,ENSG00000168291.12,PDHB,3,Pyruvate metabolism; Glycolysis / Gluconeogenesis; Central carbon metabolism in cancer; Citrate cycle (TCA cycle); Metabolic pathways; Glucagon signaling pathway; Carbon metabolism; HIF-1 signaling pathway,Glycolysis and Gluconeogenesis,Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Glyoxylate metabolism and glycine degradation,19,High,1
Q9HCC0,"Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial OS=Homo sapiens OX=9606 GN=MCCC2 PE=1 SV=1",0,398.193,63,35,1148,35,563,61.3,7.68,580604,51,33,5,cell organization and biogenesis;metabolic process,cytosol;mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding,Pf01039,64087,ENSG00000131844.15,MCCC2,5,"Valine, leucine and isoleucine degradation; Metabolic pathways",,Branched-chain amino acid catabolism; Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency,13,High,1
P27816-4,Isoform 4 of Microtubule-associated protein 4 OS=Homo sapiens OX=9606 GN=MAP4,0,396.501,45,38,1016,14,872,91.1,9.42,405333,713.13,24,18,cell division;cell organization and biogenesis;cellular component movement;regulation of biological process,cytoplasm,protein binding;RNA binding;structural molecule activity,Pf00418,4134,,MAP4,3,,,,0,High,1
P11586,"C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens OX=9606 GN=MTHFD1 PE=1 SV=3",0,396.123,58,46,849,45,935,101.5,7.3,399818,20.13,45,3,metabolic process,cytoplasm;cytosol;membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding,"Pf00763, Pf01268, Pf02882",4522,,MTHFD1,14,One carbon pool by folate; Metabolic pathways,Folate Metabolism; One Carbon Metabolism; Trans-sulfuration and one carbon metabolism,Metabolism of folate and pterines,9,High,1
P15311,Ezrin OS=Homo sapiens OX=9606 GN=EZR PE=1 SV=4,0,395.261,53,40,1889,23,586,69.4,6.27,969398,0,40,4,cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endosome;membrane,protein binding;RNA binding,"Pf00373, Pf00769, Pf09379, Pf09380",7430,ENSG00000092820.17,EZR,6,Gastric acid secretion; MicroRNAs in cancer; Regulation of actin cytoskeleton; Leukocyte transendothelial migration; Proteoglycans in cancer; Pathogenic Escherichia coli infection,Pathogenic Escherichia coli infection; AGE/RAGE pathway; VEGFA-VEGFR2 Signaling Pathway; Regulation of Actin Cytoskeleton,Netrin-1 signaling; Recycling pathway of L1,15,High,1
Q9NZM1,Myoferlin OS=Homo sapiens OX=9606 GN=MYOF PE=1 SV=1,0,394.829,34,59,519,55,2061,234.6,6.18,235138,0,59,1,cell organization and biogenesis;regulation of biological process;response to stimulus,membrane;nucleus,protein binding,"Pf00168, Pf08150, Pf08151, Pf08165",26509,ENSG00000138119.16,MYOF,10,,Aryl Hydrocarbon Receptor Pathway; Hepatitis C and Hepatocellular Carcinoma,,2,High,1
P14543,Nidogen-1 OS=Homo sapiens OX=9606 GN=NID1 PE=1 SV=3,0,392.641,38,40,662,39,1247,136.3,5.29,305413,11.75,39,4,cell organization and biogenesis;regulation of biological process,cell surface;extracellular;membrane,metal ion binding;protein binding,"Pf00008, Pf00058, Pf00086, Pf06119, Pf06247, Pf07474, Pf07645, Pf12662, Pf12947, Pf14670",4811,ENSG00000116962.14,NID1,1,,,Laminin interactions; Degradation of the extracellular matrix,3,High,1
P50395,Rab GDP dissociation inhibitor beta OS=Homo sapiens OX=9606 GN=GDI2 PE=1 SV=2,0,392.585,61,32,1106,21,445,50.6,6.47,530326,4.07,31,4,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;membrane;organelle lumen,catalytic activity;enzyme regulator activity;protein binding;RNA binding,Pf00996,2665,ENSG00000057608.16,GDI2,10,,,Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; Rho GTPase cycle,10,High,1
O95359,Transforming acidic coiled-coil-containing protein 2 OS=Homo sapiens OX=9606 GN=TACC2 PE=1 SV=3,0,392.001,30,54,265,53,2948,309.2,4.79,110411,54.72,49,9,cell organization and biogenesis;cell proliferation;cellular component movement;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,catalytic activity;motor activity;protein binding,"Pf01576, Pf02463, Pf04156, Pf05010, Pf05557, Pf05816, Pf06160, Pf07926, Pf08317, Pf09728, Pf09731, Pf10174, Pf12037, Pf12072, Pf12128, Pf13851, Pf13863, Pf13868, Pf15272, Pf15619",10579,ENSG00000138162.18,TACC2,10,,,,0,High,1
O14639-6,Isoform 6 of Actin-binding LIM protein 1 OS=Homo sapiens OX=9606 GN=ABLIM1,0,391.886,47,34,1354,7,748,84.5,8.32,626951,153.03,32,11,cell organization and biogenesis,cytoplasm;cytoskeleton,metal ion binding;protein binding,"Pf00412, Pf02209",3983,ENSG00000099204.18,ABLIM1,10,,,,0,High,1
P33176,Kinesin-1 heavy chain OS=Homo sapiens OX=9606 GN=KIF5B PE=1 SV=1,0,391.847,51,44,597,35,963,109.6,6.51,286541,,44,,cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;membrane,catalytic activity;motor activity;nucleotide binding;protein binding,"Pf00225, Pf01576, Pf02463, Pf03999, Pf04111, Pf04156, Pf05483, Pf05557, Pf05622, Pf06160, Pf07111, Pf07888, Pf10174, Pf12128, Pf13514, Pf13851, Pf14915",3799,ENSG00000170759.10,KIF5B,10,Endocytosis; Dopaminergic synapse,Insulin Signaling,COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; RHO GTPases activate KTN1; Insulin processing; MHC class II antigen presentation,21,High,1
P07339,Cathepsin D OS=Homo sapiens OX=9606 GN=CTSD PE=1 SV=1,0,390.675,53,35,2112,35,412,44.5,6.54,1078173,183.54,31,8,metabolic process;transport,extracellular;membrane;organelle lumen;vacuole,catalytic activity;protein binding,"Pf00026, Pf07966, Pf14541, Pf14543",1509,ENSG00000117984.13,CTSD,11,Apoptosis; Tuberculosis; Sphingolipid signaling pathway; Lysosome,Prolactin Signaling Pathway,Collagen degradation; Metabolism of Angiotensinogen to Angiotensins; Neutrophil degranulation; MHC class II antigen presentation,16,High,1
Q02252,"Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial OS=Homo sapiens OX=9606 GN=ALDH6A1 PE=1 SV=2",0,388.188,62,36,1281,36,535,57.8,8.5,620031,51.07,33,8,cell differentiation;metabolic process,mitochondrion;organelle lumen,catalytic activity;RNA binding,Pf00171,4329,ENSG00000119711.12,ALDH6A1,14,"Metabolic pathways; Carbon metabolism; Valine, leucine and isoleucine degradation; beta-Alanine metabolism; Inositol phosphate metabolism; Propanoate metabolism",,Branched-chain amino acid catabolism,9,High,1
Q8WX93,Palladin OS=Homo sapiens OX=9606 GN=PALLD PE=1 SV=3,0,387.812,41,40,933,10,1383,150.5,7.09,424986,63.64,35,11,cell organization and biogenesis;cellular component movement,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,protein binding,"Pf00047, Pf07679, Pf13895, Pf13927",23022,,PALLD,4,,,,0,High,1
Q7Z3D6,"D-glutamate cyclase, mitochondrial OS=Homo sapiens OX=9606 GN=DGLUCY PE=1 SV=2",0,387.808,48,27,1782,27,616,66.4,6.79,824321,106.05,25,11,metabolic process,mitochondrion;organelle lumen,catalytic activity;protein binding,"Pf07286, Pf14336",80017,ENSG00000133943.20,C14orf159; DGLUCY,14,,,,0,High,1
P00915,Carbonic anhydrase 1 OS=Homo sapiens OX=9606 GN=CA1 PE=1 SV=2,0,387.553,72,27,1498,27,261,28.9,7.12,759895,4.08,27,5,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol,catalytic activity;metal ion binding;protein binding,Pf00194,759,ENSG00000133742.13,CA1,8,Nitrogen metabolism,,Reversible hydration of carbon dioxide; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Interleukin-12 family signaling; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide,12,High,1
P05165,"Propionyl-CoA carboxylase alpha chain, mitochondrial OS=Homo sapiens OX=9606 GN=PCCA PE=1 SV=4",0,387.131,56,39,973,38,728,80,7.52,456819,10.27,37,5,metabolic process,cytosol;extracellular;mitochondrion;organelle lumen,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00289, Pf00364, Pf01071, Pf02222, Pf02258, Pf02785, Pf02786, Pf07478, Pf08442, Pf08443, Pf13437, Pf13533, Pf13535, Pf13549, Pf15632",5095,ENSG00000175198.15,PCCA,13,"Propanoate metabolism; Glyoxylate and dicarboxylate metabolism; Carbon metabolism; Valine, leucine and isoleucine degradation; Metabolic pathways",,Defective HLCS causes multiple carboxylase deficiency; Biotin transport and metabolism; Propionyl-CoA catabolism,18,High,1
P47985,"Cytochrome b-c1 complex subunit Rieske, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRFS1 PE=1 SV=2",0,386.171,69,33,4042,32,274,29.6,8.32,2009425,35.2,32,7,metabolic process;response to stimulus;transport,membrane;mitochondrion,catalytic activity;metal ion binding;protein binding;transporter activity,"Pf00355, Pf02921, Pf09165",7386,ENSG00000169021.5,UQCRFS1,19,Metabolic pathways; Huntington's disease; Oxidative phosphorylation; Parkinson's disease; Cardiac muscle contraction; Non-alcoholic fatty liver disease (NAFLD); Alzheimer's disease,Electron Transport Chain,Respiratory electron transport,12,High,1
Q9H223,EH domain-containing protein 4 OS=Homo sapiens OX=9606 GN=EHD4 PE=1 SV=1,0,384.32,71,34,1056,24,541,61.1,6.76,531345,11.1,34,6,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;endosome;membrane;nucleus,metal ion binding;nucleotide binding;protein binding,"Pf00350, Pf01926, Pf12763",30844,ENSG00000103966.10,EHD4,15,Endocytosis,,,1,High,1
Q96HC4-2,Isoform 2 of PDZ and LIM domain protein 5 OS=Homo sapiens OX=9606 GN=PDLIM5,0,384.304,73,31,2697,3,234,25.9,9.7,1189432,865.63,25,10,cell growth;regulation of biological process,cytoskeleton;cytosol;membrane,metal ion binding;protein binding,"Pf00595, Pf13180",10611,ENSG00000163110.14,PDLIM5,4,,,,0,High,1
P46821,Microtubule-associated protein 1B OS=Homo sapiens OX=9606 GN=MAP1B PE=1 SV=2,0,383.777,32,54,313,53,2468,270.5,4.81,138326,5.5,52,2,cell growth;cell organization and biogenesis;cellular component movement;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;membrane,protein binding;structural molecule activity,,4131,ENSG00000131711.14,MAP1B,5,,Regulation of Microtubule Cytoskeleton,,1,High,1
Q13683-7,Isoform Alpha-7X2B of Integrin alpha-7 OS=Homo sapiens OX=9606 GN=ITGA7,0,383.516,37,37,839,3,1137,124.2,5.92,405219,84.05,36,6,cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus,cell surface;membrane,metal ion binding;protein binding,"Pf01839, Pf08441, Pf13517",3679,ENSG00000135424.15,ITGA7,12,,Integrin-mediated Cell Adhesion; Arrhythmogenic Right Ventricular Cardiomyopathy; Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,,4,High,1
P23786,"Carnitine O-palmitoyltransferase 2, mitochondrial OS=Homo sapiens OX=9606 GN=CPT2 PE=1 SV=2",0,382.708,50,35,882,35,658,73.7,8.18,424471,7.7,34,3,metabolic process;regulation of biological process;transport,membrane;mitochondrion,catalytic activity,Pf00755,1376,ENSG00000157184.6,CPT2,1,PPAR signaling pathway; Fatty acid degradation; Fatty acid metabolism,Fatty Acid Beta Oxidation; PPAR Alpha Pathway; Mitochondrial LC-Fatty Acid Beta-Oxidation; PPAR signaling pathway,Import of palmitoyl-CoA into the mitochondrial matrix; PPARA activates gene expression,13,High,1
P01860,Immunoglobulin heavy constant gamma 3 OS=Homo sapiens OX=9606 GN=IGHG3 PE=1 SV=2,0,381.379,64,37,2220,5,377,41.3,7.9,1058210,261.11,29,10,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,catalytic activity;protein binding,"Pf07654, Pf08205",3502,,IGHG3,14,,,FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Regulation of Complement cascade; Role of phospholipids in phagocytosis; Classical antibody-mediated complement activation,11,High,1
P30038,"Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH4A1 PE=1 SV=3",0,379.419,64,35,1330,35,563,61.7,8.07,657290,68.44,34,9,metabolic process,mitochondrion;organelle lumen,catalytic activity;protein binding,Pf00171,8659,ENSG00000159423.16,ALDH4A1,1,"Alanine, aspartate and glutamate metabolism; Arginine and proline metabolism; Metabolic pathways",,Glyoxylate metabolism and glycine degradation; Proline catabolism,8,High,1
O43837,"Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=IDH3B PE=1 SV=2",0,378.019,52,23,1336,2,385,42.2,8.46,650459,24.48,23,4,metabolic process,mitochondrion;nucleus;organelle lumen,catalytic activity;metal ion binding;nucleotide binding,Pf00180,3420,ENSG00000101365.20,IDH3B,20,Metabolic pathways; Citrate cycle (TCA cycle); Biosynthesis of amino acids; 2-Oxocarboxylic acid metabolism; Carbon metabolism,TCA Cycle,Citric acid cycle (TCA cycle),10,High,1
Q96AC1,Fermitin family homolog 2 OS=Homo sapiens OX=9606 GN=FERMT2 PE=1 SV=1,0,377.404,58,33,801,33,680,77.8,6.7,374599,27.73,32,6,cell organization and biogenesis;regulation of biological process;response to stimulus,cell surface;cytoplasm;cytoskeleton;cytosol;membrane;nucleus,protein binding,"Pf00169, Pf00373",10979,ENSG00000073712.14,FERMT2,14,,,Cell-extracellular matrix interactions,3,High,1
P0DPH8,Tubulin alpha-3D chain OS=Homo sapiens OX=9606 GN=TUBA3D PE=1 SV=1,0,375.874,53,37,2115,0,450,49.9,5.1,1067989,59.91,34,8,,,,,,,,,,,,0,Not Found,1
P00403,Cytochrome c oxidase subunit 2 OS=Homo sapiens OX=9606 GN=MT-CO2 PE=1 SV=1,0,374.557,66,32,3249,32,227,25.5,4.82,1546676,42.36,31,6,metabolic process;response to stimulus;transport,membrane;mitochondrion,catalytic activity;metal ion binding;protein binding;transporter activity,"Pf00116, Pf02790",4513,ENSG00000198712.1,COX2,MT,Metabolic pathways; Alzheimer's disease; Non-alcoholic fatty liver disease (NAFLD); Parkinson's disease; Cardiac muscle contraction; Oxidative phosphorylation; Huntington's disease,Electron Transport Chain; Endothelin Pathways; EGF/EGFR Signaling Pathway,TP53 Regulates Metabolic Genes; Respiratory electron transport,19,High,1
Q9NYU2,UDP-glucose:glycoprotein glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=UGGT1 PE=1 SV=3,0,373.901,40,47,542,44,1555,177.1,5.63,239360,1.9,47,2,metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;organelle lumen,catalytic activity;protein binding,Pf06427,56886,ENSG00000136731.12,UGGT1,2,Protein processing in endoplasmic reticulum,,ER Quality Control Compartment (ERQC),7,High,1
O60763,General vesicular transport factor p115 OS=Homo sapiens OX=9606 GN=USO1 PE=1 SV=2,0,373.842,41,36,389,36,962,107.8,4.91,188008,14.3,35,4,cell organization and biogenesis;metabolic process;transport,cytoplasm;cytosol;endoplasmic reticulum;Golgi;membrane,protein binding;RNA binding;transporter activity,"Pf02403, Pf04111, Pf04869, Pf04871, Pf13166, Pf13514",8615,ENSG00000138768.14,USO1,4,,,COPII (Coat Protein 2) Mediated Vesicle Transport; COPI-mediated anterograde transport; Golgi Cisternae Pericentriolar Stack Reorganization,14,High,1
O43837-2,"Isoform A of Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=IDH3B",0,373.307,53,22,1327,1,383,41.9,7.59,645395,32.1,21,5,metabolic process,mitochondrion;nucleus;organelle lumen,catalytic activity;metal ion binding;nucleotide binding,Pf00180,3420,ENSG00000101365.20,IDH3B,20,,TCA Cycle,,1,High,1
P49753,"Acyl-coenzyme A thioesterase 2, mitochondrial OS=Homo sapiens OX=9606 GN=ACOT2 PE=1 SV=6",0,372.945,59,27,1908,1,483,53.2,8.47,936165,9.02,27,4,metabolic process,mitochondrion;organelle lumen,catalytic activity;protein binding,"Pf04775, Pf08840",10965,ENSG00000119673.14,ACOT2,14,Biosynthesis of unsaturated fatty acids; Ovarian steroidogenesis; Metabolic pathways; Fatty acid elongation,,Mitochondrial Fatty Acid Beta-Oxidation,8,High,1
P04843,Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 OS=Homo sapiens OX=9606 GN=RPN1 PE=1 SV=1,0,372.335,58,34,753,34,607,68.5,6.38,361720,0,34,2,metabolic process,cytosol;endoplasmic reticulum;membrane,catalytic activity;protein binding;RNA binding,Pf04597,6184,ENSG00000163902.11,RPN1,3,Protein processing in endoplasmic reticulum; Metabolic pathways; N-Glycan biosynthesis,Proteasome Degradation,Asparagine N-linked glycosylation; SRP-dependent cotranslational protein targeting to membrane,9,High,1
Q9NUB1,"Acetyl-coenzyme A synthetase 2-like, mitochondrial OS=Homo sapiens OX=9606 GN=ACSS1 PE=1 SV=2",0,369.707,56,29,1214,29,689,74.8,7.11,583444,67.59,25,12,metabolic process,mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding,"Pf00501, Pf13193",84532,ENSG00000154930.14,ACSS1,20,Pyruvate metabolism; Propanoate metabolism; Glycolysis / Gluconeogenesis; Carbon metabolism; Metabolic pathways,Sterol Regulatory Element-Binding Proteins (SREBP) signalling; Amino Acid metabolism; Statin Pathway,Ethanol oxidation,12,High,1
P99999,Cytochrome c OS=Homo sapiens OX=9606 GN=CYCS PE=1 SV=2,0,368.668,70,34,5885,34,105,11.7,9.57,3175885,12.76,34,6,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;membrane;mitochondrion;nucleus,catalytic activity;metal ion binding;protein binding,"Pf00034, Pf13442, Pf14495",54205,ENSG00000172115.8,CYCS,7,Pathways in cancer; Amyotrophic lateral sclerosis (ALS); Hepatitis B; Non-alcoholic fatty liver disease (NAFLD); Parkinson's disease; Legionellosis; Tuberculosis; Viral myocarditis; Colorectal cancer; Herpes simplex infection; p53 signaling pathway; Platinum drug resistance; Apoptosis; Metabolic pathways; Apoptosis - multiple species; Huntington's disease; Influenza A; Sulfur metabolism; Small cell lung cancer; Alzheimer's disease; Toxoplasmosis,miRNA Regulation of DNA Damage Response; Alzheimers Disease; AGE/RAGE pathway; Parkinsons Disease Pathway; Nanomaterial induced apoptosis; Apoptosis; Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation; Apoptosis Modulation by HSP70; Oxidative Damage; DNA Damage Response,Transcriptional activation of mitochondrial biogenesis; Activation of caspases through apoptosome-mediated cleavage; TP53 Regulates Metabolic Genes; Respiratory electron transport; Release of apoptotic factors from the mitochondria; Formation of apoptosome; Detoxification of Reactive Oxygen Species,54,High,1
P34932,Heat shock 70 kDa protein 4 OS=Homo sapiens OX=9606 GN=HSPA4 PE=1 SV=4,0,368.582,52,34,552,31,840,94.3,5.19,269519,8.99,33,3,cell organization and biogenesis;response to stimulus;transport,cytoplasm;cytosol,nucleotide binding;protein binding,"Pf00012, Pf06723",3308,ENSG00000170606.14,HSPA4,5,Antigen processing and presentation,Parkin-Ubiquitin Proteasomal System pathway,Regulation of HSF1-mediated heat shock response,6,High,1
P01859,Immunoglobulin heavy constant gamma 2 OS=Homo sapiens OX=9606 GN=IGHG2 PE=1 SV=2,0,368.498,60,34,2076,10,326,35.9,7.59,982617,194.6,31,8,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,catalytic activity;protein binding,"Pf07654, Pf08205",3501,ENSG00000211893.3; ENSG00000274497.2,IGHG2,14; CHR_HSCHR14_3_CTG1,,,FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Regulation of Complement cascade; Role of phospholipids in phagocytosis; Classical antibody-mediated complement activation,11,High,1
P02533,"Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4",0,367.75,64,42,1111,16,472,51.5,5.16,571192,6.06,42,5,cell death;cell differentiation;cell organization and biogenesis;response to stimulus,cytoplasm;cytosol;nucleus,protein binding;structural molecule activity,"Pf00038, Pf13514",3861,ENSG00000186847.5,KRT14,17,,Corticotropin-releasing hormone signaling pathway,Formation of the cornified envelope; Type I hemidesmosome assembly,7,High,1
Q02952,A-kinase anchor protein 12 OS=Homo sapiens OX=9606 GN=AKAP12 PE=1 SV=4,0,363.156,42,49,274,49,1782,191.4,4.41,123024,6.76,48,2,regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane,protein binding,Pf03832,9590,ENSG00000131016.16,AKAP12,6,,G Protein Signaling Pathways,,1,High,1
Q14974,Importin subunit beta-1 OS=Homo sapiens OX=9606 GN=KPNB1 PE=1 SV=2,0,362.993,40,28,773,28,876,97.1,4.78,385919,0,28,1,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen,metal ion binding;protein binding;RNA binding;transporter activity,"Pf02985, Pf03810, Pf13513, Pf13646",3837,ENSG00000108424.9,KPNB1,17,RNA transport,Sterol Regulatory Element-Binding Proteins (SREBP) signalling,ISG15 antiviral mechanism;  NS1 Mediated Effects on Host Pathways; Nuclear import of Rev protein; Neutrophil degranulation; Regulation of cholesterol biosynthesis by SREBP (SREBF); Transport of Ribonucleoproteins into the Host Nucleus; Activation of DNA fragmentation factor,29,High,1
Q92616,eIF-2-alpha kinase activator GCN1 OS=Homo sapiens OX=9606 GN=GCN1 PE=1 SV=6,0,361.853,29,66,411,66,2671,292.6,7.47,163979,0,66,1,cell communication;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;ribosome,enzyme regulator activity;protein binding;RNA binding,"Pf12074, Pf13646",10985,,GCN1L1; GCN1,12,,,,0,High,1
Q9NPC6,Myozenin-2 OS=Homo sapiens OX=9606 GN=MYOZ2 PE=1 SV=1,0,361.382,83,24,4092,24,264,29.9,8.25,1842969,685.32,20,15,cell organization and biogenesis,cytoplasm;cytoskeleton,protein binding,Pf05556,51778,ENSG00000172399.5,MYOZ2,4,,,,0,High,1
Q14112,Nidogen-2 OS=Homo sapiens OX=9606 GN=NID2 PE=1 SV=3,0,359.775,32,32,721,31,1375,151.2,5.29,341703,7.49,32,4,cell organization and biogenesis,cell surface;extracellular;membrane,metal ion binding;protein binding,"Pf00058, Pf00086, Pf06119, Pf06247, Pf07474, Pf07645, Pf08450, Pf12662, Pf12947, Pf14670",22795,ENSG00000087303.17,NID2,14,,,Laminin interactions,2,High,1
P62258,14-3-3 protein epsilon OS=Homo sapiens OX=9606 GN=YWHAE PE=1 SV=1,0,359.58,77,28,2240,25,255,29.2,4.74,1141395,3.29,28,7,cell organization and biogenesis;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;mitochondrion;nucleus,protein binding;RNA binding,Pf00244,7531,ENSG00000108953.16; ENSG00000274474.3,YWHAE,17; CHR_HSCHR17_2_CTG2,Cell cycle; Neurotrophin signaling pathway; Oocyte meiosis; Epstein-Barr virus infection; PI3K-Akt signaling pathway; Hippo signaling pathway; Viral carcinogenesis,Cell Cycle; Myometrial Relaxation and Contraction Pathways; VEGFA-VEGFR2 Signaling Pathway; Calcium Regulation in the Cardiac Cell; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; NADE modulates death signalling; Translocation of GLUT4 to the plasma membrane; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Signaling by Hippo; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Regulation of HSF1-mediated heat shock response; Activation of BAD and translocation to mitochondria ; Recruitment of mitotic centrosome proteins and complexes; RAB GEFs exchange GTP for GDP on RABs; HSF1 activation; TP53 Regulates Metabolic Genes; Signalling by NGF; RHO GTPases activate PKNs,65,High,1
Q8IWX7,Protein unc-45 homolog B OS=Homo sapiens OX=9606 GN=UNC45B PE=1 SV=1,0,359.139,41,37,1024,37,931,103.7,7.81,474892,206.84,30,14,cell differentiation;development;metabolic process,cytoplasm;cytosol,protein binding,"Pf11701, Pf13414",146862,ENSG00000141161.11,UNC45B,17,,,,0,High,1
Q6NZI2,Caveolae-associated protein 1 OS=Homo sapiens OX=9606 GN=CAVIN1 PE=1 SV=1,0,357.568,46,27,1249,27,390,43.5,5.6,635924,13.26,27,6,metabolic process;regulation of biological process,cytoplasm;cytosol;endoplasmic reticulum;membrane;mitochondrion;nucleus,protein binding;RNA binding,Pf15237,284119,ENSG00000177469.12,PTRF; CAVIN1,17,,,RNA Polymerase I Transcription Termination,3,High,1
Q13683-3,Isoform Alpha-7X1B of Integrin alpha-7 OS=Homo sapiens OX=9606 GN=ITGA7,0,357.541,34,35,797,1,1141,124.6,5.92,385214,71.07,34,5,cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus,cell surface;membrane,metal ion binding;protein binding,"Pf01839, Pf08441, Pf13517",3679,ENSG00000135424.15,ITGA7,12,Hypertrophic cardiomyopathy (HCM); Focal adhesion; Regulation of actin cytoskeleton; ECM-receptor interaction; Arrhythmogenic right ventricular cardiomyopathy (ARVC); PI3K-Akt signaling pathway; Dilated cardiomyopathy,Integrin-mediated Cell Adhesion; Arrhythmogenic Right Ventricular Cardiomyopathy; Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,,11,High,1
Q15063-5,Isoform 5 of Periostin OS=Homo sapiens OX=9606 GN=POSTN,0,357.534,46,36,458,36,809,90.4,7.39,210533,13.34,35,3,cell communication;cell growth;cell organization and biogenesis;regulation of biological process;response to stimulus,,metal ion binding;protein binding,"Pf02469, Pf07546",10631,ENSG00000133110.14,POSTN,13,,Hypothesized Pathways in Pathogenesis of Cardiovascular Disease; Amplification and Expansion of Oncogenic Pathways as Metastatic Traits,,2,High,1
P63316,"Troponin C, slow skeletal and cardiac muscles OS=Homo sapiens OX=9606 GN=TNNC1 PE=1 SV=1",0,356.909,88,15,2949,15,161,18.4,4.18,1301670,1692.94,11,11,cellular component movement;regulation of biological process;response to stimulus,cytosol,metal ion binding;protein binding,"Pf00036, Pf13202, Pf13405, Pf13499, Pf13833",7134,ENSG00000114854.7,TNNC1,3,Dilated cardiomyopathy; Cardiac muscle contraction; Calcium signaling pathway; Hypertrophic cardiomyopathy (HCM); Adrenergic signaling in cardiomyocytes,MFAP5-mediated ovarian cancer cell motility and invasiveness; Striated Muscle Contraction,Striated Muscle Contraction,9,High,1
Q9P2R7,"Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLA2 PE=1 SV=3",0,356.459,60,31,2131,31,463,50.3,7.42,1046542,30.85,27,11,metabolic process,mitochondrion;organelle lumen,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00549, Pf01071, Pf02222, Pf08442, Pf13535, Pf13549",8803,ENSG00000136143.14,SUCLA2,13,Propanoate metabolism; Carbon metabolism; Metabolic pathways; Citrate cycle (TCA cycle),,Citric acid cycle (TCA cycle),8,High,1
O75083,WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=WDR1 PE=1 SV=4,0,355.692,59,27,874,27,606,66.2,6.65,420000,37.45,24,7,cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;extracellular,protein binding,"Pf00400, Pf04762, Pf08662, Pf14783",9948,ENSG00000071127.16,WDR1,4,,Hypertrophy Model,Platelet degranulation,5,High,1
Q93008-1,Isoform 2 of Probable ubiquitin carboxyl-terminal hydrolase FAF-X OS=Homo sapiens OX=9606 GN=USP9X,0,355.452,24,52,402,28,2554,290.3,5.8,169996,14.16,51,2,cell division;cell growth;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;protein binding,"Pf00443, Pf13423",8239,ENSG00000124486.12,USP9X,X,,,,0,High,1
P30153,Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R1A PE=1 SV=4,0,355.048,48,27,1180,22,589,65.3,5.11,582341,19.5,26,8,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus,catalytic activity;enzyme regulator activity;protein binding,"Pf02985, Pf13513, Pf13646",5518,ENSG00000105568.17,PPP2R1A,19,TGF-beta signaling pathway; Sphingolipid signaling pathway; Long-term depression; Hippo signaling pathway; Chagas disease (American trypanosomiasis); Hepatitis C; mRNA surveillance pathway; Adrenergic signaling in cardiomyocytes; PI3K-Akt signaling pathway; Oocyte meiosis; AMPK signaling pathway; Tight junction; Dopaminergic synapse,Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Wnt Signaling Pathway and Pluripotency; Glycogen Metabolism,"Glycolysis; Regulation of PLK1 Activity at G2/M Transition; AXIN missense mutants destabilize the destruction complex; PP2A-mediated dephosphorylation of key metabolic factors; APC truncation mutants have impaired AXIN binding; CTLA4 inhibitory signaling; Activated TLR4 signalling; Separation of Sister Chromatids; MASTL Facilitates Mitotic Progression; S37 mutants of beta-catenin aren't phosphorylated; AURKA Activation by TPX2; S33 mutants of beta-catenin aren't phosphorylated; Anchoring of the basal body to the plasma membrane; S45 mutants of beta-catenin aren't phosphorylated; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Recruitment of mitotic centrosome proteins and complexes; Misspliced GSK3beta mutants stabilize beta-catenin; Cyclin A/B1/B2 associated events during G2/M transition; T41 mutants of beta-catenin aren't phosphorylated; RAF activation; ERKs are inactivated; Beta-catenin phosphorylation cascade; Negative regulation of MAPK pathway; Recruitment of NuMA to mitotic centrosomes; Initiation of Nuclear Envelope Reformation; Loss of Nlp from mitotic centrosomes; Platelet sensitization by LDL; Signaling by GPCR; Interleukin-20 family signaling; Spry regulation of FGF signaling; DARPP-32 events; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Regulation of TP53 Degradation; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Cyclin D associated events in G1; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; Truncations of AMER1 destabilize the destruction complex",150,High,1
P09493-5,Isoform 5 of Tropomyosin alpha-1 chain OS=Homo sapiens OX=9606 GN=TPM1,0,354.911,60,37,7855,4,245,28.4,4.77,4288128,251.2,33,11,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cytoskeleton;cytosol,protein binding;structural molecule activity,"Pf00261, Pf12718",7168,ENSG00000140416.19,TPM1,15,,Striated Muscle Contraction,,1,High,1
O15382,"Branched-chain-amino-acid aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=BCAT2 PE=1 SV=2",0,354.757,51,27,1228,27,392,44.3,8.65,584132,11.51,27,6,metabolic process,cytoplasm;mitochondrion;organelle lumen,catalytic activity,Pf01063,587,ENSG00000105552.14,BCAT2,19,"Metabolic pathways; Valine, leucine and isoleucine degradation; Valine, leucine and isoleucine biosynthesis; Pantothenate and CoA biosynthesis; Cysteine and methionine metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids",,Branched-chain amino acid catabolism,10,High,1
P50213,"Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=IDH3A PE=1 SV=1",0,354.254,60,28,2316,28,366,39.6,6.92,1097103,28.95,26,7,metabolic process,mitochondrion;nucleus;organelle lumen,catalytic activity;metal ion binding;nucleotide binding,Pf00180,3419,ENSG00000166411.13,IDH3A,15,Citrate cycle (TCA cycle); 2-Oxocarboxylic acid metabolism; Carbon metabolism; Metabolic pathways; Biosynthesis of amino acids,TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc); TCA Cycle,Citric acid cycle (TCA cycle),11,High,1
Q9H7Z7,Prostaglandin E synthase 2 OS=Homo sapiens OX=9606 GN=PTGES2 PE=1 SV=1,0,354.172,62,26,911,26,377,41.9,9.16,446226,8.32,26,4,cellular homeostasis;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;extracellular;Golgi;membrane;mitochondrion;nucleus;organelle lumen,catalytic activity;DNA binding;protein binding,"Pf00043, Pf00462, Pf13409, Pf13410, Pf13417, Pf14497",80142,ENSG00000148334.14,PTGES2,9,Arachidonic acid metabolism; Metabolic pathways,Eicosanoid Synthesis,Synthesis of Prostaglandins (PG) and Thromboxanes (TX); Neutrophil degranulation,11,High,1
Q9UI47,Catenin alpha-3 OS=Homo sapiens OX=9606 GN=CTNNA3 PE=1 SV=2,0,353.589,45,33,1137,32,895,99.7,6.16,495160,243.27,24,16,regulation of biological process,cytoplasm;cytoskeleton,protein binding,Pf01044,29119,ENSG00000183230.16,CTNNA3,10,Adherens junction; Tight junction; Endometrial cancer; Leukocyte transendothelial migration; Pathways in cancer; Hippo signaling pathway; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Bacterial invasion of epithelial cells,Arrhythmogenic Right Ventricular Cardiomyopathy,,9,High,1
Q8NI60,"Atypical kinase COQ8A, mitochondrial OS=Homo sapiens OX=9606 GN=COQ8A PE=1 SV=1",0,353.515,40,27,1211,13,647,71.9,6.99,570368,38.97,25,7,metabolic process,membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding,Pf03109,56997,ENSG00000163050.16,ADCK3; COQ8A,1,,,,0,High,1
P22061,Protein-L-isoaspartate(D-aspartate) O-methyltransferase OS=Homo sapiens OX=9606 GN=PCMT1 PE=1 SV=4,0,353.502,67,25,923,25,227,24.6,7.21,471326,1.65,25,2,metabolic process,cytoplasm;cytosol,catalytic activity;protein binding,"Pf01135, Pf01209, Pf05175, Pf06325, Pf08241, Pf12847, Pf13489, Pf13659, Pf13847",5110,,PCMT1,6,,,Protein repair,2,High,1
P07942,Laminin subunit beta-1 OS=Homo sapiens OX=9606 GN=LAMB1 PE=1 SV=2,0,353.453,21,34,840,34,1786,197.9,4.94,412504,10.11,33,5,cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane;organelle lumen,catalytic activity;motor activity;nucleotide binding;protein binding;signal transducer activity;structural molecule activity,"Pf00015, Pf00053, Pf00055, Pf01576, Pf02841, Pf03938, Pf04156, Pf05103, Pf05335, Pf05667, Pf05698, Pf05701, Pf06428, Pf07111, Pf07767, Pf08317, Pf08647, Pf09731, Pf10174, Pf13476, Pf13514, Pf13851, Pf15346, Pf15619",3912,ENSG00000091136.13,LAMB1,7,Amoebiasis; Toxoplasmosis; ECM-receptor interaction; Focal adhesion; Pathways in cancer; PI3K-Akt signaling pathway; Small cell lung cancer,Alpha 6 Beta 4 signaling pathway; Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Inflammatory Response Pathway,ECM proteoglycans; Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); L1CAM interactions; Laminin interactions; Degradation of the extracellular matrix; MET activates PTK2 signaling; Non-integrin membrane-ECM interactions,28,High,1
P27144,"Adenylate kinase 4, mitochondrial OS=Homo sapiens OX=9606 GN=AK4 PE=1 SV=1",0,353.237,78,33,1417,32,223,25.3,8.4,724945,0,33,2,metabolic process;response to stimulus,mitochondrion;organelle lumen,catalytic activity;nucleotide binding,"Pf00406, Pf05191, Pf13207, Pf13238, Pf13671",205,ENSG00000162433.14,AK4; LOC100507855,1,Purine metabolism; Thiamine metabolism; Metabolic pathways,,Interconversion of nucleotide di- and triphosphates,6,High,1
P16219,"Short-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADS PE=1 SV=1",0,351.188,55,25,1641,25,412,44.3,7.99,772444,22.73,23,8,metabolic process,mitochondrion;nucleus;organelle lumen,catalytic activity;nucleotide binding,"Pf00441, Pf02770, Pf02771, Pf08028",35,ENSG00000122971.8,ACADS,12,"Metabolic pathways; Butanoate metabolism; Fatty acid metabolism; Carbon metabolism; Valine, leucine and isoleucine degradation; Fatty acid degradation",Fatty Acid Beta Oxidation; Mitochondrial LC-Fatty Acid Beta-Oxidation,Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA,15,High,1
Q14152,Eukaryotic translation initiation factor 3 subunit A OS=Homo sapiens OX=9606 GN=EIF3A PE=1 SV=1,0,349.895,30,41,591,41,1382,166.5,6.79,276366,2.3,41,3,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;nucleus,protein binding;RNA binding;structural molecule activity,Pf01399,8661,ENSG00000107581.12,EIF3A,10,RNA transport,Translation Factors,"Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Ribosomal scanning and start codon recognition",13,High,1
Q12931,"Heat shock protein 75 kDa, mitochondrial OS=Homo sapiens OX=9606 GN=TRAP1 PE=1 SV=3",0,347.93,51,31,784,30,704,80.1,8.21,371548,,31,,metabolic process;regulation of biological process;response to stimulus,membrane;mitochondrion;organelle lumen,nucleotide binding;protein binding;RNA binding,"Pf00183, Pf02518, Pf13589",10131,ENSG00000126602.10,TRAP1,16,,TNF alpha Signaling Pathway; TGF-beta Signaling Pathway,Respiratory electron transport,6,High,1
Q6ZP82,Coiled-coil domain-containing protein 141 OS=Homo sapiens OX=9606 GN=CCDC141 PE=1 SV=2,0,347.826,34,39,467,39,1450,166.2,5.58,141570,347.94,22,28,,cytoplasm;cytoskeleton,protein binding,Pf07679,285025,,CCDC141,2,,,,0,High,1
Q86TX2,Acyl-coenzyme A thioesterase 1 OS=Homo sapiens OX=9606 GN=ACOT1 PE=1 SV=1,0,347.549,73,28,1797,2,421,46.2,7.34,891176,10.88,28,4,metabolic process,cytoplasm;cytosol,catalytic activity,"Pf04775, Pf08840",641371,ENSG00000184227.7,ACOT1,14,Fatty acid elongation; Metabolic pathways; Biosynthesis of unsaturated fatty acids,,Mitochondrial Fatty Acid Beta-Oxidation,7,High,1
Q86TC9,Myopalladin OS=Homo sapiens OX=9606 GN=MYPN PE=1 SV=2,0,347.208,40,34,552,34,1320,145.2,6.77,214984,183.56,27,9,cell organization and biogenesis;regulation of biological process,cytoplasm;nucleus,protein binding,"Pf00047, Pf07679, Pf13895, Pf13927",84665,ENSG00000138347.15,MYPN,10,,Integrin-mediated Cell Adhesion,,1,High,1
P08779,"Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4",0,346.094,61,40,1083,20,473,51.2,5.05,567215,3.97,40,5,cell death;cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;defense response;regulation of biological process;response to stimulus,cytoskeleton;cytosol;nucleus,protein binding;structural molecule activity,"Pf00038, Pf07888, Pf13514",3868,ENSG00000186832.8,KRT16,17,,,Formation of the cornified envelope,3,High,1
P30086,Phosphatidylethanolamine-binding protein 1 OS=Homo sapiens OX=9606 GN=PEBP1 PE=1 SV=3,0,345.926,86,27,1851,27,187,21,7.53,1003811,97.27,25,6,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,enzyme regulator activity;nucleotide binding;protein binding;RNA binding,Pf01161,5037,ENSG00000089220.4,PEBP1,12,,EGF/EGFR Signaling Pathway,Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling by BRAF and RAF fusions; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; Interleukin-20 family signaling,19,High,1
O14958,Calsequestrin-2 OS=Homo sapiens OX=9606 GN=CASQ2 PE=1 SV=2,0,344.981,65,28,2324,28,399,46.4,4.37,1062967,302.01,25,11,cell communication;cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;membrane;organelle lumen,metal ion binding;protein binding,"Pf01216, Pf13848",845,ENSG00000118729.11,CASQ2,1,,Calcium Regulation in the Cardiac Cell,Ion homeostasis; Stimuli-sensing channels,7,High,1
P02790,Hemopexin OS=Homo sapiens OX=9606 GN=HPX PE=1 SV=2,0,344.252,62,34,1356,34,462,51.6,7.02,628922,198.03,28,9,cellular homeostasis;metabolic process;regulation of biological process;transport,extracellular;organelle lumen,metal ion binding;protein binding;transporter activity,Pf00045,3263,ENSG00000110169.10,HPX,11,,,Scavenging of heme from plasma,3,High,1
P05091,"Aldehyde dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH2 PE=1 SV=2",0,343.12,63,34,1603,30,517,56.3,7.05,836277,24.15,32,9,metabolic process,mitochondrion;organelle lumen,catalytic activity;nucleotide binding,Pf00171,217,ENSG00000111275.12,ALDH2,12,"Glycolysis / Gluconeogenesis; Histidine metabolism; Tryptophan metabolism; Pyruvate metabolism; Ascorbate and aldarate metabolism; Valine, leucine and isoleucine degradation; Pentose and glucuronate interconversions; Glycerolipid metabolism; beta-Alanine metabolism; Arginine and proline metabolism; Lysine degradation; Metabolic pathways; Fatty acid degradation",Fatty Acid Omega Oxidation; Tryptophan metabolism,Ethanol oxidation; Metabolism of serotonin,24,High,1
Q16363,Laminin subunit alpha-4 OS=Homo sapiens OX=9606 GN=LAMA4 PE=1 SV=4,0,343.052,28,41,482,41,1823,202.4,6.28,210000,4.04,41,5,cell organization and biogenesis;regulation of biological process;transport,cytoskeleton;extracellular;membrane,catalytic activity;motor activity;protein binding;structural molecule activity,"Pf00053, Pf00054, Pf00529, Pf01576, Pf02210, Pf03302, Pf05483, Pf06008, Pf06009, Pf06160, Pf07888, Pf10174, Pf12128, Pf13385, Pf13868, Pf14662",3910,,LAMA4,6,Pathways in cancer; African trypanosomiasis; Toxoplasmosis; PI3K-Akt signaling pathway; Focal adhesion; Small cell lung cancer; Amoebiasis; ECM-receptor interaction,miRNA targets in ECM and membrane receptors; Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,ECM proteoglycans; Laminin interactions; MET activates PTK2 signaling; Non-integrin membrane-ECM interactions,20,High,1
P01861,Immunoglobulin heavy constant gamma 4 OS=Homo sapiens OX=9606 GN=IGHG4 PE=1 SV=1,0,342.589,56,33,1499,3,327,35.9,7.36,705045,130.43,29,5,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,catalytic activity;protein binding,"Pf07654, Pf08205",3503,ENSG00000211892.3; ENSG00000277016.2,IGHG4,14; CHR_HSCHR14_3_CTG1,,,Regulation of Complement cascade; Classical antibody-mediated complement activation; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Interleukin-4 and 13 signaling; Role of phospholipids in phagocytosis,14,High,1
Q14126,Desmoglein-2 OS=Homo sapiens OX=9606 GN=DSG2 PE=1 SV=2,0,342.481,44,29,416,29,1118,122.2,5.24,213036,5.96,29,4,cell death;cell organization and biogenesis;regulation of biological process;response to stimulus,cell surface;cytoskeleton;membrane,metal ion binding;protein binding,"Pf00028, Pf01049",1829,ENSG00000046604.12,DSG2,18,Arrhythmogenic right ventricular cardiomyopathy (ARVC),Arrhythmogenic Right Ventricular Cardiomyopathy,Apoptotic cleavage of cell adhesion  proteins; Formation of the cornified envelope,10,High,1
O95299,"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFA10 PE=1 SV=1",0,342.47,61,29,1726,29,355,40.7,8.48,810219,130.2,25,10,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion;organelle lumen,catalytic activity,"Pf01712, Pf13207",4705,ENSG00000281434.2; ENSG00000130414.11,NDUFA10,2; CHR_HG2233_PATCH,Alzheimer's disease; Oxidative phosphorylation; Huntington's disease; Metabolic pathways; Non-alcoholic fatty liver disease (NAFLD); Parkinson's disease,Electron Transport Chain; Oxidative phosphorylation,Complex I biogenesis,13,High,1
Q8WUM4-2,Isoform 2 of Programmed cell death 6-interacting protein OS=Homo sapiens OX=9606 GN=PDCD6IP,0,341.178,50,40,740,39,873,96.7,6.52,343264,24.28,39,2,cell death;cell organization and biogenesis;regulation of biological process;transport,cytosol;membrane,protein binding,"Pf03097, Pf08391, Pf13949",10015,ENSG00000170248.13,PDCD6IP,3,,,,0,High,1
Q14118,Dystroglycan OS=Homo sapiens OX=9606 GN=DAG1 PE=1 SV=2,0,341.155,25,25,924,25,895,97.4,8.56,434801,37.84,24,4,cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen,metal ion binding;protein binding;receptor activity;structural molecule activity,Pf05454,1605,ENSG00000173402.11,DAG1,3,Dilated cardiomyopathy; ECM-receptor interaction; Viral myocarditis; Hypertrophic cardiomyopathy (HCM); Arrhythmogenic right ventricular cardiomyopathy (ARVC),Integrated Breast Cancer Pathway; Arrhythmogenic Right Ventricular Cardiomyopathy; Primary Focal Segmental Glomerulosclerosis FSGS,"ECM proteoglycans; Integrin cell surface interactions; Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1; Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3; Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2; Regulation of expression of SLITs and ROBOs; O-linked glycosylation; Non-integrin membrane-ECM interactions",25,High,1
P31937,"3-hydroxyisobutyrate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=HIBADH PE=1 SV=2",0,340.845,59,29,1778,29,336,35.3,8.13,848061,44.43,27,7,metabolic process;transport,mitochondrion;organelle lumen,catalytic activity;nucleotide binding,"Pf02254, Pf02826, Pf03446, Pf03807, Pf14833",11112,ENSG00000106049.8,HIBADH,7,"Metabolic pathways; Valine, leucine and isoleucine degradation",Amino Acid metabolism,Branched-chain amino acid catabolism,6,High,1
P08758,Annexin A5 OS=Homo sapiens OX=9606 GN=ANXA5 PE=1 SV=2,0,340.839,69,31,1924,29,320,35.9,5.05,899188,3.47,31,6,coagulation;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;membrane,enzyme regulator activity;metal ion binding;protein binding,Pf00191,308,ENSG00000164111.14,ANXA5,4,,Apoptosis-related network due to altered Notch3 in ovarian cancer; Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway; Prostaglandin Synthesis and Regulation,Platelet degranulation,7,High,1
Q9BZQ8,Protein Niban 1 OS=Homo sapiens OX=9606 GN=NIBAN1 PE=1 SV=1,0,340.76,40,31,872,31,928,103.1,4.78,391404,86.02,27,8,regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,protein binding,,116496,ENSG00000135842.16,FAM129A,1,,,,0,High,1
O14639-5,Isoform 5 of Actin-binding LIM protein 1 OS=Homo sapiens OX=9606 GN=ABLIM1,0,340.461,66,28,1031,1,455,52,9.19,462344,158.78,26,9,cell organization and biogenesis,cytoplasm;cytoskeleton,metal ion binding;protein binding,Pf02209,3983,ENSG00000099204.18,ABLIM1,10,,,,0,High,1
Q9UHQ9,NADH-cytochrome b5 reductase 1 OS=Homo sapiens OX=9606 GN=CYB5R1 PE=1 SV=1,0,339.838,58,31,1678,27,305,34.1,9.38,815752,35.32,30,6,metabolic process;transport,membrane;mitochondrion,catalytic activity;protein binding,"Pf00175, Pf00970",51706,ENSG00000159348.12,CYB5R1,1,Amino sugar and nucleotide sugar metabolism,Oxidation by Cytochrome P450,Platelet degranulation ; Erythrocytes take up carbon dioxide and release oxygen,9,High,1
P52272,Heterogeneous nuclear ribonucleoprotein M OS=Homo sapiens OX=9606 GN=HNRNPM PE=1 SV=3,0,337.528,63,36,616,36,730,77.5,8.7,287544,1.73,36,2,metabolic process;regulation of biological process;response to stimulus,membrane;nucleus;spliceosomal complex,protein binding;RNA binding,"Pf00076, Pf11532, Pf11608, Pf13893, Pf14259",4670,ENSG00000099783.11,HNRNPM,19,Spliceosome,mRNA Processing,mRNA Splicing - Major Pathway; FGFR2 alternative splicing,11,High,1
P40763,Signal transducer and activator of transcription 3 OS=Homo sapiens OX=9606 GN=STAT3 PE=1 SV=2,0,336.942,44,28,474,28,770,88,6.3,228156,0,28,2,cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;defense response;metabolic process;regulation of biological process;reproduction;response to stimulus;transport,cytoplasm;cytosol;membrane;mitochondrion;nucleus,DNA binding;protein binding;signal transducer activity,"Pf00017, Pf01017, Pf02864, Pf02865",6774,ENSG00000168610.14,STAT3,17,AGE-RAGE signaling pathway in diabetic complications; MicroRNAs in cancer; Hepatitis B; Chemokine signaling pathway; Jak-STAT signaling pathway; Acute myeloid leukemia; FoxO signaling pathway; Adipocytokine signaling pathway; Viral carcinogenesis; Measles; EGFR tyrosine kinase inhibitor resistance; HIF-1 signaling pathway; Signaling pathways regulating pluripotency of stem cells; Pathways in cancer; Inflammatory bowel disease (IBD); Hepatitis C; Epstein-Barr virus infection; Proteoglycans in cancer; Prolactin signaling pathway; Toxoplasmosis; Pancreatic cancer; Insulin resistance,IL-5 Signaling Pathway; Androgen receptor signaling pathway; Physiological and Pathological Hypertrophy  of the Heart; MicroRNAs in cardiomyocyte hypertrophy; TFs Regulate miRNAs related to cardiac hypertrophy; Cell Differentiation - Index; Human Thyroid Stimulating Hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin Signaling Pathway; Regulation of Microtubule Cytoskeleton; IL-7 Signaling Pathway; IL17 signaling pathway; IL-9 Signaling Pathway; AGE/RAGE pathway; Interleukin-11 Signaling Pathway; Adipogenesis; Oncostatin M Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Dopaminergic Neurogenesis; IL-3 Signaling Pathway; TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer; Estrogen Receptor Pathway; Kit receptor signaling pathway; Signaling of Hepatocyte Growth Factor Receptor; Rac1/Pak1/p38/MMP-2 pathway; IL-6 signaling pathway; Hepatitis C and Hepatocellular Carcinoma; VEGFA-VEGFR2 Signaling Pathway; Development of pulmonary dendritic cells and macrophage subsets; Chemokine signaling pathway; ESC Pluripotency Pathways; Leptin Insulin Overlap; IL-4 Signaling Pathway; EGF/EGFR Signaling Pathway; IL-2 Signaling Pathway; TGF-beta Receptor Signaling; EPO Receptor Signaling; Interferon type I signaling pathways; Notch Signaling Pathway; Serotonin Receptor 2 and STAT3 Signaling,"Interleukin-15 signaling; Signaling by Leptin; POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation; Interleukin-35 Signalling; Interleukin-10 signaling; Interleukin-7 signaling; Downstream signal transduction; Signalling to STAT3; Association of TriC/CCT with target proteins during biosynthesis; Signaling by cytosolic FGFR1 fusion mutants; MET activates STAT3; Signaling by SCF-KIT; Interleukin-6 family signaling; Interleukin-4 and 13 signaling; Senescence-Associated Secretory Phenotype (SASP); Growth hormone receptor signaling; PTK6 Activates STAT3; Interleukin-20 family signaling",106,High,1
Q9Y4L1,Hypoxia up-regulated protein 1 OS=Homo sapiens OX=9606 GN=HYOU1 PE=1 SV=1,0,336.469,47,38,587,38,999,111.3,5.22,251598,0,38,1,regulation of biological process;response to stimulus;transport,endoplasmic reticulum;extracellular;membrane;organelle lumen,nucleotide binding;protein binding,Pf00012,10525,ENSG00000280682.2; ENSG00000149428.18,HYOU1,11; CHR_HG2217_PATCH,Protein processing in endoplasmic reticulum,,Scavenging by Class F Receptors; XBP1(S) activates chaperone genes,8,High,1
P01008,Antithrombin-III OS=Homo sapiens OX=9606 GN=SERPINC1 PE=1 SV=1,0,336.467,55,29,866,29,464,52.6,6.71,426861,11.32,28,3,coagulation;defense response;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane;organelle lumen,enzyme regulator activity;protein binding,Pf00079,462,ENSG00000117601.13,SERPINC1,1,Complement and coagulation cascades,Complement and Coagulation Cascades,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Common Pathway of Fibrin Clot Formation; Intrinsic Pathway of Fibrin Clot Formation,10,High,1
Q9Y305,"Acyl-coenzyme A thioesterase 9, mitochondrial OS=Homo sapiens OX=9606 GN=ACOT9 PE=1 SV=2",0,336.251,55,27,1407,1,439,49.9,8.6,693722,6.8,26,7,metabolic process,mitochondrion;organelle lumen,catalytic activity,Pf03061,23597,ENSG00000123130.16,ACOT9,X,,,Mitochondrial Fatty Acid Beta-Oxidation,4,High,1
Q7KZF4,Staphylococcal nuclease domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SND1 PE=1 SV=1,0,335.902,51,36,461,36,910,101.9,7.17,199462,0,36,2,cell differentiation;metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;mitochondrion;nucleus,catalytic activity;protein binding;RNA binding,"Pf00565, Pf00567",27044,ENSG00000197157.10,SND1,7,Epstein-Barr virus infection; Viral carcinogenesis,,Signaling by BRAF and RAF fusions,6,High,1
P53597,"Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLG1 PE=1 SV=4",0,335.108,43,28,2234,28,346,36.2,8.79,1081480,58.19,27,5,metabolic process,cytosol;membrane;mitochondrion;organelle lumen,catalytic activity;nucleotide binding;RNA binding,"Pf00549, Pf02629, Pf13607",8802,ENSG00000163541.11,SUCLG1,2,Carbon metabolism; Propanoate metabolism; Metabolic pathways; Citrate cycle (TCA cycle),Amino Acid metabolism; TCA Cycle,Citric acid cycle (TCA cycle),10,High,1
P53621,Coatomer subunit alpha OS=Homo sapiens OX=9606 GN=COPA PE=1 SV=2,0,334.821,40,40,483,39,1224,138.3,7.66,218407,2.18,40,5,regulation of biological process;transport,cytoplasm;cytosol;extracellular;Golgi;membrane,protein binding;structural molecule activity,"Pf00400, Pf04053, Pf06957",1314,ENSG00000122218.14,COPA,1,,,COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport,11,High,1
O43491,Band 4.1-like protein 2 OS=Homo sapiens OX=9606 GN=EPB41L2 PE=1 SV=1,0,334.672,51,42,422,38,1005,112.5,5.44,198605,0,41,1,cell division;cell organization and biogenesis;transport,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,protein binding;structural molecule activity,"Pf00373, Pf04382, Pf05902, Pf08736, Pf09379, Pf09380",2037,ENSG00000079819.18,EPB41L2,6,Tight junction,,Neurexins and neuroligins,4,High,1
P12956,X-ray repair cross-complementing protein 6 OS=Homo sapiens OX=9606 GN=XRCC6 PE=1 SV=2,0,334.524,50,36,615,36,609,69.8,6.64,297125,0,36,2,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,chromosome;cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen,catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding,"Pf02037, Pf02735, Pf03730, Pf03731",2547,ENSG00000196419.12,XRCC6,22,Non-homologous end-joining,Non-homologous end joining,2-LTR circle formation; Neutrophil degranulation; IRF3-mediated induction of type I IFN; Nonhomologous End-Joining (NHEJ),18,High,1
P21397,Amine oxidase [flavin-containing] A OS=Homo sapiens OX=9606 GN=MAOA PE=1 SV=1,0,333.447,50,26,1584,24,527,59.6,7.85,792304,0,26,2,metabolic process,membrane;mitochondrion,catalytic activity,"Pf01593, Pf13450",4128,ENSG00000189221.9,MAOA,X,"Metabolic pathways; Phenylalanine metabolism; Amphetamine addiction; Serotonergic synapse; Tryptophan metabolism; Cocaine addiction; Histidine metabolism; Tyrosine metabolism; Arginine and proline metabolism; Alcoholism; Drug metabolism - cytochrome P450; Glycine, serine and threonine metabolism; Dopaminergic synapse",Serotonin Transporter Activity; Dopamine metabolism; Melatonin metabolism and effects; Amino Acid metabolism; Oxidative Stress; Biogenic Amine Synthesis; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,Enzymatic degradation of dopamine by COMT; Enzymatic degradation of Dopamine by monoamine oxidase; Defective MAOA causes Brunner syndrome (BRUNS); Norepinephrine Neurotransmitter Release Cycle; Interleukin-4 and 13 signaling; Metabolism of serotonin; Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB,43,High,1
O75489,"NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS3 PE=1 SV=1",0,333.017,58,30,1864,30,264,30.2,7.5,980997,3.12,30,4,cell organization and biogenesis;metabolic process;regulation of biological process;transport,membrane;mitochondrion;organelle lumen,catalytic activity;protein binding,Pf00329,4722,ENSG00000213619.9,NDUFS3,11,Huntington's disease; Alzheimer's disease; Metabolic pathways; Oxidative phosphorylation; Parkinson's disease; Non-alcoholic fatty liver disease (NAFLD),Electron Transport Chain; Oxidative phosphorylation,Complex I biogenesis,13,High,1
Q9NZN3,EH domain-containing protein 3 OS=Homo sapiens OX=9606 GN=EHD3 PE=1 SV=2,0,331.447,71,34,884,15,535,60.8,6.57,425375,0,33,6,cell organization and biogenesis;coagulation;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;endosome;membrane;nucleus,metal ion binding;nucleotide binding;protein binding,"Pf00350, Pf01926, Pf12763",30845,ENSG00000013016.15,EHD3,2,Endocytosis,,Factors involved in megakaryocyte development and platelet production,3,High,1
P50570,Dynamin-2 OS=Homo sapiens OX=9606 GN=DNM2 PE=1 SV=2,0,330.542,47,42,678,26,870,98,7.44,309211,1.61,42,3,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endosome;Golgi;membrane;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00169, Pf00350, Pf01031, Pf02212",1785,ENSG00000079805.16,DNM2,19,Synaptic vesicle cycle; Endocytosis; Bacterial invasion of epithelial cells; Phospholipase D signaling pathway; Fc gamma R-mediated phagocytosis; Endocrine and other factor-regulated calcium reabsorption,Synaptic Vesicle Pathway,Formation of annular gap junctions; Toll Like Receptor 4 (TLR4) Cascade; Clathrin-mediated endocytosis; NOSTRIN mediated eNOS trafficking; Golgi Associated Vesicle Biogenesis; Recycling pathway of L1; Lysosome Vesicle Biogenesis; Retrograde neurotrophin signalling; MHC class II antigen presentation,37,High,1
Q53GG5-2,Isoform 2 of PDZ and LIM domain protein 3 OS=Homo sapiens OX=9606 GN=PDLIM3,0,330.244,70,19,665,7,316,34.3,7.71,244520,604.74,10,10,cell organization and biogenesis,cytoskeleton;cytosol,metal ion binding;protein binding;structural molecule activity,"Pf00412, Pf00595, Pf13180",27295,ENSG00000154553.13,PDLIM3,4,,,,0,High,1
Q8NF91,Nesprin-1 OS=Homo sapiens OX=9606 GN=SYNE1 PE=1 SV=4,0,329.178,11,67,274,2,8797,1010.5,5.53,109783,1.64,67,3,cell differentiation;cell organization and biogenesis,cytoplasm;cytoskeleton;Golgi;membrane;nucleus,protein binding;RNA binding,"Pf00307, Pf00435, Pf10541",23345,ENSG00000131018.22,SYNE1,6,,,Meiotic synapsis,4,High,1
P28289,Tropomodulin-1 OS=Homo sapiens OX=9606 GN=TMOD1 PE=1 SV=1,0,328.985,70,26,1061,25,359,40.5,5.1,533750,53.7,26,5,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane,metal ion binding;protein binding,Pf03250,7111,ENSG00000136842.13,TMOD1,9,,Striated Muscle Contraction,Striated Muscle Contraction,3,High,1
Q9Y512,Sorting and assembly machinery component 50 homolog OS=Homo sapiens OX=9606 GN=SAMM50 PE=1 SV=3,0,328.273,72,32,1237,32,469,51.9,6.9,612625,38.62,29,8,cell organization and biogenesis;transport,cytoplasm;membrane;mitochondrion,protein binding,"Pf01103, Pf07244",25813,ENSG00000100347.14,SAMM50,22,,,Cristae formation; Mitochondrial protein import; Metabolism of proteins,5,High,1
Q13510,Acid ceramidase OS=Homo sapiens OX=9606 GN=ASAH1 PE=1 SV=5,0,326.893,49,29,1427,29,395,44.6,7.62,673705,34.82,28,7,metabolic process;transport,extracellular;organelle lumen;vacuole,catalytic activity,"Pf02275, Pf15508",427,ENSG00000104763.18,ASAH1,8,Sphingolipid metabolism; Sphingolipid signaling pathway; Lysosome; Metabolic pathways,Sphingolipid Metabolism; Signal Transduction of S1P Receptor,Glycosphingolipid metabolism; Neutrophil degranulation,13,High,1
P34931,Heat shock 70 kDa protein 1-like OS=Homo sapiens OX=9606 GN=HSPA1L PE=1 SV=2,0,326.735,37,31,1593,1,641,70.3,6.02,781020,6.08,31,5,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytosol;mitochondrion;organelle lumen,nucleotide binding;protein binding,"Pf00012, Pf06723",3305,ENSG00000234258.6; ENSG00000204390.9,HSPA1L,6; CHR_HSCHR6_MHC_DBB_CTG1,Antigen processing and presentation; Measles; Epstein-Barr virus infection; Estrogen signaling pathway; Protein processing in endoplasmic reticulum; Endocytosis; Spliceosome; Legionellosis; Longevity regulating pathway - multiple species; Influenza A; Toxoplasmosis; MAPK signaling pathway,Parkin-Ubiquitin Proteasomal System pathway,Attenuation phase; HSP90 chaperone cycle for steroid hormone receptors (SHR); Regulation of HSF1-mediated heat shock response,20,High,1
Q99497,Protein/nucleic acid deglycase DJ-1 OS=Homo sapiens OX=9606 GN=PARK7 PE=1 SV=2,0,326.442,81,25,1333,25,189,19.9,6.79,573709,386.64,22,8,cell communication;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,chromosome;cytoplasm;cytosol;endoplasmic reticulum;membrane;mitochondrion;nucleus;organelle lumen,antioxidant activity;catalytic activity;DNA binding;enzyme regulator activity;metal ion binding;protein binding;RNA binding,"Pf01965, Pf13278",11315,ENSG00000116288.12,PARK7,1,Parkinson's disease,Androgen receptor signaling pathway; Synaptic Vesicle Pathway; Parkinsons Disease Pathway,,4,High,1
P17858,"ATP-dependent 6-phosphofructokinase, liver type OS=Homo sapiens OX=9606 GN=PFKL PE=1 SV=6",0,326.15,36,27,1260,16,780,85,7.5,603070,2.58,27,2,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;membrane;organelle lumen,catalytic activity;metal ion binding;nucleotide binding;protein binding,Pf00365,5211,ENSG00000141959.16,PFKL,21,Glycolysis / Gluconeogenesis; Glucagon signaling pathway; Metabolic pathways; Pentose phosphate pathway; Carbon metabolism; RNA degradation; HIF-1 signaling pathway; AMPK signaling pathway; Fructose and mannose metabolism; Galactose metabolism; Biosynthesis of amino acids; Central carbon metabolism in cancer,Photodynamic therapy-induced HIF-1 survival signaling; Insulin Signaling; Glycolysis and Gluconeogenesis,Glycolysis; Neutrophil degranulation,22,High,1
P68104,Elongation factor 1-alpha 1 OS=Homo sapiens OX=9606 GN=EEF1A1 PE=1 SV=1,0,325.875,64,33,2975,1,462,50.1,9.01,1545678,25.77,32,7,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00009, Pf03143, Pf03144",1915,ENSG00000156508.17,EEF1A1,6,Legionellosis; RNA transport,Translation Factors,Peptide chain elongation; Protein methylation; Neutrophil degranulation; HSF1 activation,16,High,1
Q8NF91-4,Isoform 4 of Nesprin-1 OS=Homo sapiens OX=9606 GN=SYNE1,0,325.214,11,66,263,1,8749,1004.6,5.52,102793,9.63,65,4,cell differentiation;cell organization and biogenesis,cytoplasm;cytoskeleton;Golgi;membrane;nucleus,protein binding;RNA binding,"Pf00307, Pf00435, Pf10541",23345,,SYNE1,6,,,,0,High,1
Q9Y305-4,"Isoform 4 of Acyl-coenzyme A thioesterase 9, mitochondrial OS=Homo sapiens OX=9606 GN=ACOT9",0,324.456,56,27,1332,1,448,50.8,8.53,656306,9.22,25,8,metabolic process,mitochondrion;organelle lumen,catalytic activity,Pf03061,23597,ENSG00000123130.16,ACOT9,X,,,,0,High,1
Q96I99,"Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLG2 PE=1 SV=2",0,323.998,67,32,1514,32,432,46.5,6.39,759484,71.85,30,6,metabolic process,membrane;mitochondrion;organelle lumen,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00549, Pf01071, Pf08442, Pf13549",8801,ENSG00000172340.14,SUCLG2,3,Propanoate metabolism; Carbon metabolism; Citrate cycle (TCA cycle); Metabolic pathways,TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc); TCA Cycle,Citric acid cycle (TCA cycle),10,High,1
Q14764,Major vault protein OS=Homo sapiens OX=9606 GN=MVP PE=1 SV=4,0,323.906,53,38,426,38,893,99.3,5.48,196385,1.85,38,3,regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen,protein binding,"Pf01145, Pf01505, Pf11978",9961,ENSG00000013364.18,MVP,16,,,Neutrophil degranulation,3,High,1
Q9Y276,Mitochondrial chaperone BCS1 OS=Homo sapiens OX=9606 GN=BCS1L PE=1 SV=1,0,323.77,64,26,653,25,419,47.5,8.5,323225,52.74,24,6,cell organization and biogenesis;metabolic process,membrane;mitochondrion,catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding,"Pf00004, Pf00910, Pf06431, Pf08740",617,ENSG00000074582.12,BCS1L,2,,,Mitochondrial protein import; Metabolism of proteins,2,High,1
Q08211,ATP-dependent RNA helicase A OS=Homo sapiens OX=9606 GN=DHX9 PE=1 SV=4,0,323.403,32,34,533,34,1270,140.9,6.84,232853,2.19,34,6,cell death;cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane;nucleus;ribosome,catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding,"Pf00035, Pf00270, Pf00271, Pf04408, Pf07717",1660,ENSG00000135829.16,DHX9,1,,mRNA Processing,TRAF6 mediated NF-kB activation; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; RIP-mediated NFkB activation via ZBP1; Activated TLR4 signalling; Interleukin-1 family signaling; mRNA Splicing - Major Pathway; DEx/H-box helicases activate type I IFN and inflammatory cytokines production,34,High,1
O75643,U5 small nuclear ribonucleoprotein 200 kDa helicase OS=Homo sapiens OX=9606 GN=SNRNP200 PE=1 SV=2,0,323.379,31,48,261,48,2136,244.4,6.06,105309,0,48,1,cell differentiation;cell organization and biogenesis;metabolic process,membrane;nucleus;spliceosomal complex,catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding,"Pf00270, Pf00271, Pf02889, Pf04851",23020,ENSG00000144028.14,SNRNP200,2,Spliceosome,,mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway,6,High,1
A1L0T0,Acetolactate synthase-like protein OS=Homo sapiens OX=9606 GN=ILVBL PE=1 SV=2,0,321.924,49,23,523,23,632,67.8,8.15,258974,1.82,23,3,,membrane,catalytic activity;metal ion binding;protein binding,"Pf00205, Pf02775, Pf02776",10994,ENSG00000105135.15,ILVBL,19,,,,0,High,1
Q15075,Early endosome antigen 1 OS=Homo sapiens OX=9606 GN=EEA1 PE=1 SV=2,0,321.59,41,48,260,48,1411,162.4,5.68,112902,2.37,48,1,cell organization and biogenesis;metabolic process;transport,cytoplasm;cytosol;endosome;membrane,catalytic activity;metal ion binding;motor activity;protein binding;transporter activity,"Pf01363, Pf01496, Pf01576, Pf04156, Pf05478, Pf09726, Pf10498, Pf12128, Pf13166",8411,ENSG00000102189.16,EEA1,12,Tuberculosis; Phagosome; Endocytosis,VEGFA-VEGFR2 Signaling Pathway,Toll Like Receptor 9 (TLR9) Cascade,8,High,1
P48643,T-complex protein 1 subunit epsilon OS=Homo sapiens OX=9606 GN=CCT5 PE=1 SV=1,0,320.583,55,33,719,33,541,59.6,5.66,348901,0,33,3,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol,nucleotide binding;protein binding;RNA binding,Pf00118,22948,ENSG00000150753.11,CCT5,5,,,BBSome-mediated cargo-targeting to cilium; Prefoldin mediated transfer of substrate  to CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Formation of tubulin folding intermediates by CCT/TriC; Folding of actin by CCT/TriC,13,High,1
Q5VTE0,Putative elongation factor 1-alpha-like 3 OS=Homo sapiens OX=9606 GN=EEF1A1P5 PE=5 SV=1,0,320.44,58,32,2970,1,462,50.2,9.07,1544554,25.77,31,7,metabolic process,cytoplasm;nucleus,catalytic activity;nucleotide binding;RNA binding,"Pf00009, Pf03143, Pf03144",158078,,EEF1A1P5,9,,,Eukaryotic Translation Elongation,3,High,1
Q14980,Nuclear mitotic apparatus protein 1 OS=Homo sapiens OX=9606 GN=NUMA1 PE=1 SV=2,0,320.391,32,49,225,49,2115,238.1,5.78,101741,0,49,1,cell differentiation;cell division;cell organization and biogenesis;metabolic process;regulation of biological process,chromosome;cytoplasm;cytoskeleton;cytosol;membrane;nucleus,protein binding;structural molecule activity,"Pf04111, Pf07888, Pf12128",4926,ENSG00000137497.17,NUMA1,11,,Ectoderm Differentiation,Mitotic Prophase; Recruitment of NuMA to mitotic centrosomes,7,High,1
O75323,Protein NipSnap homolog 2 OS=Homo sapiens OX=9606 GN=NIPSNAP2 PE=1 SV=1,0,320.028,60,24,875,22,286,33.7,9.36,408338,62.76,22,5,metabolic process;regulation of biological process,cytoplasm;membrane;mitochondrion,protein binding,Pf07978,2631,ENSG00000146729.9,GBAS; NIPSNAP2,7,,,,0,High,1
Q92523,"Carnitine O-palmitoyltransferase 1, muscle isoform OS=Homo sapiens OX=9606 GN=CPT1B PE=1 SV=2",0,318.707,48,29,1236,28,772,87.7,8.62,557046,307.36,25,12,metabolic process;transport,membrane;mitochondrion,catalytic activity;protein binding,Pf00755,1375,ENSG00000205560.12,CPT1B,22,Insulin resistance; PPAR signaling pathway; Adipocytokine signaling pathway; Glucagon signaling pathway; Fatty acid metabolism; AMPK signaling pathway; Fatty acid degradation,AMP-activated Protein Kinase (AMPK) Signaling; Fatty Acid Beta Oxidation; PPAR signaling pathway,Signaling by Retinoic Acid; Import of palmitoyl-CoA into the mitochondrial matrix,17,High,1
Q13228,Methanethiol oxidase OS=Homo sapiens OX=9606 GN=SELENBP1 PE=1 SV=2,0,318.586,66,29,1192,29,472,52.4,6.37,540792,39.55,28,2,transport,cytoplasm;cytosol;membrane;nucleus,protein binding,"Pf05694, Pf10282",8991,ENSG00000143416.20,SELENBP1,1,,Selenium Metabolism and Selenoproteins; IL1 and megakaryocytes in obesity,,2,High,1
P13647,"Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3",0,318.389,51,42,937,24,590,62.3,7.74,460910,2.3,42,3,cell death;cell organization and biogenesis;metabolic process,cytoplasm;cytosol;membrane;mitochondrion;nucleus,catalytic activity;motor activity;protein binding;structural molecule activity,"Pf00038, Pf01576, Pf02994, Pf03961, Pf04111, Pf05957, Pf12128",3852,ENSG00000186081.11,KRT5,12,,,Formation of the cornified envelope; Type I hemidesmosome assembly,6,High,1
O00151,PDZ and LIM domain protein 1 OS=Homo sapiens OX=9606 GN=PDLIM1 PE=1 SV=4,0,316.979,63,24,670,24,329,36,7.02,348063,19.06,24,4,regulation of biological process;response to stimulus,cytoplasm;cytoskeleton,metal ion binding;protein binding,"Pf00412, Pf00595, Pf13180",9124,ENSG00000107438.8,PDLIM1,10,,,,0,High,1
P42345,Serine/threonine-protein kinase mTOR OS=Homo sapiens OX=9606 GN=MTOR PE=1 SV=1,0,316.952,27,50,319,50,2549,288.7,7.17,131442,4.93,49,4,cell communication;cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;Golgi;membrane;mitochondrion;nucleus;vacuole,catalytic activity;DNA binding;nucleotide binding;protein binding,"Pf00454, Pf02259, Pf02260, Pf08771, Pf11865",2475,ENSG00000198793.12,MTOR,1,Longevity regulating pathway - multiple species; Proteoglycans in cancer; Prostate cancer; Breast cancer; Longevity regulating pathway; HIF-1 signaling pathway; AMPK signaling pathway; EGFR tyrosine kinase inhibitor resistance; ErbB signaling pathway; Phospholipase D signaling pathway; Insulin resistance; Thyroid hormone signaling pathway; Central carbon metabolism in cancer; mTOR signaling pathway; Pathways in cancer; Insulin signaling pathway; Choline metabolism in cancer; Type II diabetes mellitus; PI3K-Akt signaling pathway; Jak-STAT signaling pathway; Acute myeloid leukemia; Adipocytokine signaling pathway; Glioma; MicroRNAs in cancer; Endocrine resistance,"AMP-activated Protein Kinase (AMPK) Signaling; Target Of Rapamycin (TOR) Signaling; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; Sterol Regulatory Element-Binding Proteins (SREBP) signalling; Integrated Breast Cancer Pathway; SREBF and miR33 in cholesterol and lipid homeostasis; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; Human Thyroid Stimulating Hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle Stimulating Hormone (FSH) signaling pathway; Prolactin Signaling Pathway; Oncostatin M Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Alpha 6 Beta 4 signaling pathway; Cardiac Hypertrophic Response; Extracellular vesicle-mediated signaling in recipient cells; Mecp2 and Associated Rett Syndrome; Wnt Signaling Pathway Netpath; BDNF-TrkB Signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; ATM Signaling Network in Development and Disease; 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; ESC Pluripotency Pathways; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; EGF/EGFR Signaling Pathway; Insulin Signaling; Interferon type I signaling pathways; Senescence and Autophagy in Cancer; ErbB Signaling Pathway",HSF1-dependent transactivation; Regulation of TP53 Degradation; mTORC1-mediated signalling; Constitutive Signaling by AKT1 E17K in Cancer; Energy dependent regulation of mTOR by LKB1-AMPK; CD28 dependent PI3K/Akt signaling; Regulation of PTEN gene transcription; VEGFR2 mediated vascular permeability; TP53 Regulates Metabolic Genes; Macroautophagy,92,High,1
O14558,Heat shock protein beta-6 OS=Homo sapiens OX=9606 GN=HSPB6 PE=1 SV=2,0,316.78,79,22,1526,22,160,17.1,6.4,757967,74.51,22,4,metabolic process;regulation of biological process,cytoplasm;extracellular;nucleus,protein binding;structural molecule activity,Pf00011,126393,ENSG00000004776.12,HSPB6,19,,,,0,High,1
Q9H845,"Complex I assembly factor ACAD9, mitochondrial OS=Homo sapiens OX=9606 GN=ACAD9 PE=1 SV=1",0,316.548,51,30,689,30,621,68.7,7.96,326783,10.66,29,7,cell organization and biogenesis;metabolic process,membrane;mitochondrion;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00441, Pf02770, Pf02771, Pf08028",28976,ENSG00000177646.18,ACAD9,3,,,Complex I biogenesis,5,High,1
Q14894,Ketimine reductase mu-crystallin OS=Homo sapiens OX=9606 GN=CRYM PE=1 SV=1,0,316.359,72,23,1362,23,314,33.8,5.14,666107,51.19,22,8,metabolic process;regulation of biological process;transport,cytoplasm;cytosol;mitochondrion;nucleus;organelle lumen,catalytic activity;nucleotide binding;protein binding,"Pf01488, Pf02423, Pf03446, Pf03807",1428,ENSG00000103316.10; ENSG00000283922.1,CRYM,16; CHR_HG926_PATCH,,,Lysine catabolism,4,High,1
O75208,"Ubiquinone biosynthesis protein COQ9, mitochondrial OS=Homo sapiens OX=9606 GN=COQ9 PE=1 SV=1",0,316.234,66,20,1433,20,318,35.5,5.94,733783,51.25,18,7,metabolic process,membrane;mitochondrion,protein binding,Pf08511,57017,ENSG00000088682.13,COQ9,16,,,Ubiquinol biosynthesis,4,High,1
Q9NQC3,Reticulon-4 OS=Homo sapiens OX=9606 GN=RTN4 PE=1 SV=2,0,315.213,45,35,376,22,1192,129.9,4.5,177411,11.48,33,3,cell death;cell organization and biogenesis;cellular component movement;regulation of biological process,endoplasmic reticulum;membrane,protein binding;RNA binding,Pf02453,57142,ENSG00000115310.17,RTN4,2,Alzheimer's disease,Spinal Cord Injury,Signalling by NGF; Axonal growth inhibition (RHOA activation),8,High,1
Q9Y2Z9,"Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial OS=Homo sapiens OX=9606 GN=COQ6 PE=1 SV=2",0,313.321,55,25,997,25,468,50.8,7.3,454621,177.15,22,8,metabolic process,Golgi;membrane;mitochondrion,catalytic activity;nucleotide binding,Pf01494,51004,ENSG00000119723.16,COQ6,14,Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways,,Ubiquinol biosynthesis,6,High,1
A0A0B4J2D5,"Glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial OS=Homo sapiens OX=9606 GN=GATD3B PE=1 SV=1",0,312.864,60,23,1149,23,268,28.1,8.27,526745,155.32,22,6,,mitochondrion,,Pf01965,8209; 102724023,ENSG00000280071.3,C21orf33; LOC102724023,21,,Gastric Cancer Network 1,,1,High,1
P45954,"Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADSB PE=1 SV=1",0,312.01,53,25,924,25,432,47.5,6.99,474473,4.4,25,2,metabolic process,mitochondrion;organelle lumen,catalytic activity;nucleotide binding,"Pf00441, Pf02770, Pf02771, Pf08028",36,ENSG00000196177.12,ACADSB,10,"Metabolic pathways; Fatty acid metabolism; Fatty acid degradation; Valine, leucine and isoleucine degradation",Valproic acid pathway,Branched-chain amino acid catabolism,8,High,1
P0CG39,POTE ankyrin domain family member J OS=Homo sapiens OX=9606 GN=POTEJ PE=3 SV=1,0,310.471,14,37,19538,1,1038,117.3,5.97,10507514,8.65,37,5,,,protein binding,"Pf00022, Pf00023, Pf12796, Pf13606, Pf13637, Pf13857, Pf14915",653781,ENSG00000222038.3,POTEJ,2,,,,0,High,1
P61978-3,Isoform 3 of Heterogeneous nuclear ribonucleoprotein K OS=Homo sapiens OX=9606 GN=HNRNPK,0,310.315,55,28,915,1,440,48.5,5.54,441538,10.15,27,5,metabolic process;regulation of biological process;response to stimulus,cytoplasm;membrane;nucleus;spliceosomal complex,DNA binding;protein binding;RNA binding,"Pf00013, Pf08067, Pf13014, Pf13083",3190,,HNRNPK,9,,mRNA Processing,,1,High,1
P12694,"2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=BCKDHA PE=1 SV=2",0,310.294,59,22,678,22,445,50.4,8.27,334431,0,22,2,metabolic process,mitochondrion;organelle lumen,catalytic activity;metal ion binding;protein binding,"Pf00456, Pf00676",593,ENSG00000248098.11,BCKDHA,19,"Metabolic pathways; Valine, leucine and isoleucine degradation; Propanoate metabolism",,Branched-chain amino acid catabolism; Glyoxylate metabolism and glycine degradation,7,High,1
Q99460,26S proteasome non-ATPase regulatory subunit 1 OS=Homo sapiens OX=9606 GN=PSMD1 PE=1 SV=2,0,309.95,41,29,553,29,953,105.8,5.39,261891,0,28,4,metabolic process;regulation of biological process;response to stimulus;transport,cytosol;extracellular;membrane;nucleus;organelle lumen;proteasome,catalytic activity;enzyme regulator activity;protein binding,"Pf01851, Pf13513, Pf13646",5707,ENSG00000173692.12,PSMD1,2,Epstein-Barr virus infection; Proteasome,Proteasome Degradation; Parkin-Ubiquitin Proteasomal System pathway,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Neutrophil degranulation; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,153,High,1
O00410,Importin-5 OS=Homo sapiens OX=9606 GN=IPO5 PE=1 SV=4,0,309.074,36,28,542,24,1097,123.6,4.94,282384,0,28,1,regulation of biological process;response to stimulus;transport,cytoplasm;membrane;nucleus,enzyme regulator activity;protein binding;RNA binding;transporter activity,"Pf02985, Pf12755, Pf13513, Pf13646",3843,ENSG00000065150.18,IPO5,13,,,vRNP Assembly,6,High,1
P43243,Matrin-3 OS=Homo sapiens OX=9606 GN=MATR3 PE=1 SV=2,0,308.983,39,33,499,33,847,94.6,6.25,215940,1.69,33,1,defense response;regulation of biological process;response to stimulus,membrane;nucleus,metal ion binding;protein binding;RNA binding;structural molecule activity,"Pf00076, Pf13893, Pf14259",9782,ENSG00000015479.18; ENSG00000280987.4,MATR3,5,,,,0,High,1
O14841,5-oxoprolinase OS=Homo sapiens OX=9606 GN=OPLAH PE=1 SV=3,0,308.377,32,29,334,29,1288,137.4,6.58,150138,0,28,3,metabolic process,cytosol,catalytic activity;nucleotide binding,"Pf01968, Pf02538, Pf05378",26873,ENSG00000178814.16,OPLAH,8,Glutathione metabolism,Glutathione metabolism,Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD); Glutathione synthesis and recycling,11,High,1
P31948,Stress-induced-phosphoprotein 1 OS=Homo sapiens OX=9606 GN=STIP1 PE=1 SV=1,0,307.046,41,31,760,31,543,62.6,6.8,355507,5.13,30,4,response to stimulus,cytoplasm;cytosol;Golgi;nucleus,protein binding;RNA binding,"Pf00515, Pf12895, Pf13414, Pf13424, Pf13432",10963,ENSG00000168439.16,STIP1,11,Prion diseases,,HSP90 chaperone cycle for steroid hormone receptors (SHR),4,High,1
Q8WXH0,Nesprin-2 OS=Homo sapiens OX=9606 GN=SYNE2 PE=1 SV=3,0,306.718,12,64,243,61,6885,795.9,5.36,101447,3.51,63,2,cell organization and biogenesis;cellular component movement;regulation of biological process;transport,cytoplasm;cytoskeleton;endoplasmic reticulum;membrane;mitochondrion;nucleus;organelle lumen,protein binding,"Pf00307, Pf00435, Pf10541, Pf11971, Pf13654",23224,ENSG00000054654.16,SYNE2,14,,Ovarian Infertility Genes,Meiotic synapsis,5,High,1
P27797,Calreticulin OS=Homo sapiens OX=9606 GN=CALR PE=1 SV=1,0,306.643,68,24,791,24,417,48.1,4.44,361324,47.78,22,5,cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;cytosol;endoplasmic reticulum;extracellular;Golgi;membrane;nucleus;organelle lumen,DNA binding;metal ion binding;protein binding;RNA binding,Pf00262,811,ENSG00000179218.13,CALR,19,HTLV-I infection; Antigen processing and presentation; Protein processing in endoplasmic reticulum; Phagosome; Chagas disease (American trypanosomiasis),Androgen receptor signaling pathway; Photodynamic therapy-induced unfolded protein response; Calcium Regulation in the Cardiac Cell,"Scavenging by Class F Receptors; Assembly of Viral Components at the Budding Site; ATF6 (ATF6-alpha) activates chaperone genes; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; ER-Phagosome pathway; Calnexin/calreticulin cycle; Scavenging by Class A Receptors",32,High,1
P61978,Heterogeneous nuclear ribonucleoprotein K OS=Homo sapiens OX=9606 GN=HNRNPK PE=1 SV=1,0,305.506,58,28,912,1,463,50.9,5.54,441538,2.25,27,5,metabolic process;regulation of biological process;response to stimulus,cytoplasm;membrane;nucleus;spliceosomal complex,DNA binding;protein binding;RNA binding,"Pf00013, Pf08067, Pf13014, Pf13083",3190,ENSG00000165119.20,HNRNPK,9,Viral carcinogenesis; Spliceosome; Herpes simplex infection; MicroRNAs in cancer,mRNA Processing,mRNA Splicing - Major Pathway; SUMOylation of RNA binding proteins,14,High,1
P05413,"Fatty acid-binding protein, heart OS=Homo sapiens OX=9606 GN=FABP3 PE=1 SV=4",0,305.45,95,28,6804,26,133,14.8,6.8,3410593,569.81,23,13,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol,protein binding;transporter activity,"Pf00061, Pf14651",2170,ENSG00000121769.7,FABP3,1,PPAR signaling pathway,PPAR signaling pathway,Triglyceride catabolism,6,High,1
P35232,Prohibitin OS=Homo sapiens OX=9606 GN=PHB PE=1 SV=1,0,304.181,82,30,1992,30,272,29.8,5.76,971428,35.49,29,5,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;endosome;membrane;mitochondrion;nucleus,DNA binding;protein binding,Pf01145,5245,ENSG00000167085.11,PHB,17,,Integrated Breast Cancer Pathway,Paradoxical activation of RAF signaling by kinase inactive BRAF; Processing of SMDT1; RAF activation; Signaling by RAS mutants; Signaling by moderate kinase activity BRAF mutants; Interleukin-20 family signaling,19,High,1
P12829,Myosin light chain 4 OS=Homo sapiens OX=9606 GN=MYL4 PE=1 SV=3,0,303.296,91,25,1488,19,197,21.6,5.03,684702,136.44,23,7,cellular component movement;regulation of biological process,cytosol,metal ion binding;protein binding,Pf13499,4635,ENSG00000198336.9,MYL4,17,Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes,Myometrial Relaxation and Contraction Pathways; Striated Muscle Contraction,Striated Muscle Contraction,6,High,1
P51659,Peroxisomal multifunctional enzyme type 2 OS=Homo sapiens OX=9606 GN=HSD17B4 PE=1 SV=3,0,303.241,46,27,528,27,736,79.6,8.84,256229,46.19,26,3,cell differentiation;metabolic process,membrane;mitochondrion;organelle lumen,catalytic activity;protein binding,"Pf00106, Pf01575, Pf02036, Pf08659, Pf13452, Pf13561, Pf14864",3295,ENSG00000133835.14,HSD17B4,5,Metabolic pathways; Peroxisome; Primary bile acid biosynthesis,Steroid Biosynthesis,Beta-oxidation of pristanoyl-CoA; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of very long chain fatty acids,16,High,1
P04040,Catalase OS=Homo sapiens OX=9606 GN=CAT PE=1 SV=3,0,302.793,57,27,562,27,527,59.7,7.39,286331,0,27,2,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;endoplasmic reticulum;extracellular;Golgi;membrane;mitochondrion;organelle lumen;vacuole,antioxidant activity;catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00199, Pf06628",847,ENSG00000121691.4,CAT,11,Longevity regulating pathway - multiple species; FoxO signaling pathway; Tryptophan metabolism; Amyotrophic lateral sclerosis (ALS); Carbon metabolism; Peroxisome; Longevity regulating pathway; Glyoxylate and dicarboxylate metabolism,Selenium Micronutrient Network; Folate Metabolism; Amyotrophic lateral sclerosis (ALS); Oxidative Stress; Tryptophan metabolism; DNA Damage Response (only ATM dependent),Neutrophil degranulation; Detoxification of Reactive Oxygen Species,20,High,1
P12110,Collagen alpha-2(VI) chain OS=Homo sapiens OX=9606 GN=COL6A2 PE=1 SV=4,0,301.334,30,29,949,29,1019,108.5,6.21,496815,2.9,28,1,cell organization and biogenesis;metabolic process;response to stimulus,extracellular;membrane;organelle lumen,protein binding,"Pf00092, Pf01391, Pf13519",1292,ENSG00000142173.14,COL6A2,21,ECM-receptor interaction; Protein digestion and absorption; PI3K-Akt signaling pathway; Focal adhesion,miRNA targets in ECM and membrane receptors; Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,ECM proteoglycans; Collagen degradation; Integrin cell surface interactions; Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization; NCAM1 interactions; Signaling by PDGF,23,High,1
P07384,Calpain-1 catalytic subunit OS=Homo sapiens OX=9606 GN=CAPN1 PE=1 SV=1,0,300.896,49,33,544,33,714,81.8,5.67,255486,11.37,32,3,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;extracellular;membrane;mitochondrion;vacuole,catalytic activity;metal ion binding;protein binding,"Pf00648, Pf01067, Pf13833",823,ENSG00000014216.15,CAPN1,11,Protein processing in endoplasmic reticulum; Apoptosis; Alzheimer's disease,Integrin-mediated Cell Adhesion; Alzheimers Disease; Focal Adhesion,Degradation of the extracellular matrix; Formation of the cornified envelope; Neutrophil degranulation; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models,17,High,1
Q8IWW8,"Hydroxyacid-oxoacid transhydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ADHFE1 PE=1 SV=1",0,300.621,61,20,660,20,467,50.3,7.77,301875,69.69,18,6,metabolic process;transport,cytosol;mitochondrion;organelle lumen,catalytic activity;metal ion binding,"Pf00465, Pf13685",137872,ENSG00000147576.15,ADHFE1,8,,,Interconversion of 2-oxoglutarate and 2-hydroxyglutarate,4,High,1
P09960,Leukotriene A-4 hydrolase OS=Homo sapiens OX=9606 GN=LTA4H PE=1 SV=2,0,300.374,52,30,643,30,611,69.2,6.18,303669,6.63,30,3,metabolic process;transport,cytoplasm;cytosol;extracellular;nucleus,catalytic activity;metal ion binding;protein binding;RNA binding,"Pf01433, Pf09127, Pf13485",4048,ENSG00000111144.9,LTA4H,12,Metabolic pathways; Arachidonic acid metabolism,Eicosanoid Synthesis,Synthesis of Leukotrienes (LT) and Eoxins (EX); Neutrophil degranulation,11,High,1
P19827,Inter-alpha-trypsin inhibitor heavy chain H1 OS=Homo sapiens OX=9606 GN=ITIH1 PE=1 SV=3,0,300.229,41,27,542,27,911,101.3,6.79,251861,0,27,1,metabolic process;regulation of biological process,extracellular,enzyme regulator activity;metal ion binding,"Pf00092, Pf06668, Pf08487, Pf10138, Pf11775, Pf13519, Pf13768",3697,ENSG00000055957.10,ITIH1,3,,,,0,High,1
Q9P0J0,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 OS=Homo sapiens OX=9606 GN=NDUFA13 PE=1 SV=3,0,299.593,67,26,1681,26,144,16.7,8.43,872578,98.97,26,4,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;membrane;mitochondrion;nucleus,catalytic activity;nucleotide binding;protein binding,Pf06212,51079,ENSG00000186010.18,NDUFA13,19,Parkinson's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Alzheimer's disease; Huntington's disease; Metabolic pathways,Nucleotide-binding Oligomerization Domain (NOD) pathway; EGF/EGFR Signaling Pathway,Complex I biogenesis,13,High,1
Q9UHG3,Prenylcysteine oxidase 1 OS=Homo sapiens OX=9606 GN=PCYOX1 PE=1 SV=3,0,299.564,61,24,781,24,505,56.6,6.18,364693,25.53,23,5,metabolic process;transport,membrane;vacuole,catalytic activity;transporter activity,"Pf01593, Pf07156",51449,ENSG00000116005.11,PCYOX1,2,Terpenoid backbone biosynthesis,,,1,High,1
P30084,"Enoyl-CoA hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=ECHS1 PE=1 SV=4",0,299.452,58,33,1871,33,290,31.4,8.07,899432,85.21,31,7,metabolic process,mitochondrion;organelle lumen,catalytic activity;protein binding,"Pf00378, Pf01343",1892,ENSG00000127884.4,ECHS1,10,"Fatty acid metabolism; Fatty acid elongation; Fatty acid degradation; Tryptophan metabolism; Lysine degradation; Propanoate metabolism; Valine, leucine and isoleucine degradation; Butanoate metabolism; Metabolic pathways; beta-Alanine metabolism; Carbon metabolism",Fatty Acid Beta Oxidation; Fatty Acid Biosynthesis; Tryptophan metabolism,Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA,24,High,1
P05166,"Propionyl-CoA carboxylase beta chain, mitochondrial OS=Homo sapiens OX=9606 GN=PCCB PE=1 SV=3",0,298.843,58,25,799,25,539,58.2,7.64,390446,32.25,22,6,metabolic process,cytosol;mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding,Pf01039,5096,ENSG00000114054.13,PCCB,3,"Metabolic pathways; Valine, leucine and isoleucine degradation; Propanoate metabolism; Glyoxylate and dicarboxylate metabolism; Carbon metabolism",,Defective HLCS causes multiple carboxylase deficiency; Biotin transport and metabolism; Propionyl-CoA catabolism,18,High,1
Q07960,Rho GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=ARHGAP1 PE=1 SV=1,0,298.285,66,24,745,24,439,50.4,6.29,343259,0,24,4,regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane,enzyme regulator activity;protein binding,"Pf00620, Pf00650, Pf13716",392,ENSG00000175220.11,ARHGAP1,11,,,Rho GTPase cycle,3,High,1
P30049,"ATP synthase subunit delta, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1D PE=1 SV=2",0,298.11,82,18,1062,18,168,17.5,5.49,507538,6.51,18,2,cell organization and biogenesis;metabolic process;response to stimulus;transport,membrane;mitochondrion;organelle lumen,catalytic activity;nucleotide binding;transporter activity,Pf02823,513,ENSG00000099624.7,ATP5D,19,Alzheimer's disease; Huntington's disease; Oxidative phosphorylation; Parkinson's disease; Metabolic pathways,Electron Transport Chain; Oxidative phosphorylation,Cristae formation; Formation of ATP by chemiosmotic coupling,14,High,1
Q8WX93-9,Isoform 9 of Palladin OS=Homo sapiens OX=9606 GN=PALLD,0,298.067,38,31,743,1,1123,123.6,6.87,336337,94.95,25,10,cell organization and biogenesis;cellular component movement,cytoskeleton;cytosol;membrane;nucleus,protein binding,"Pf00047, Pf07679, Pf13895, Pf13927",23022,ENSG00000129116.17,PALLD,4,,,,0,High,1
P49368,T-complex protein 1 subunit gamma OS=Homo sapiens OX=9606 GN=CCT3 PE=1 SV=4,0,297.729,49,30,605,30,545,60.5,6.49,292745,8.04,29,4,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;membrane,nucleotide binding;protein binding;RNA binding,Pf00118,7203,ENSG00000163468.14,CCT3,1,,,BBSome-mediated cargo-targeting to cilium; Prefoldin mediated transfer of substrate  to CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Formation of tubulin folding intermediates by CCT/TriC; Folding of actin by CCT/TriC,13,High,1
Q5HYK3,"2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial OS=Homo sapiens OX=9606 GN=COQ5 PE=1 SV=2",0,297.07,70,22,607,22,327,37.1,6.95,291165,42.3,20,4,metabolic process,membrane;mitochondrion;organelle lumen,catalytic activity;protein binding,"Pf01170, Pf01209, Pf08241, Pf08242, Pf12847, Pf13489, Pf13649, Pf13659, Pf13847",84274,ENSG00000110871.14,COQ5,12,Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways,,Ubiquinol biosynthesis,6,High,1
Q9GZV1,Ankyrin repeat domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ANKRD2 PE=1 SV=3,0,296.789,62,22,734,22,360,39.8,6.09,327413,240.59,18,13,cell differentiation;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,protein binding;structural molecule activity,"Pf00023, Pf12796, Pf13606, Pf13637, Pf13857",26287,ENSG00000165887.11,ANKRD2,10,,,,0,High,1
Q8TCS8,"Polyribonucleotide nucleotidyltransferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=PNPT1 PE=1 SV=2",0,296.243,48,35,639,35,783,85.9,7.77,317059,0,35,3,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;mitochondrion;nucleus;ribosome,catalytic activity;protein binding;RNA binding,"Pf00013, Pf00575, Pf01138, Pf03725, Pf03726",87178,ENSG00000138035.14,PNPT1,2,Purine metabolism; RNA degradation; Pyrimidine metabolism,,,3,High,1
P63010,AP-2 complex subunit beta OS=Homo sapiens OX=9606 GN=AP2B1 PE=1 SV=1,0,295.968,46,36,545,26,937,104.5,5.38,256492,0,36,3,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;membrane,protein binding;transporter activity,"Pf01602, Pf02883, Pf09066, Pf12717, Pf13646",163,ENSG00000006125.17,AP2B1,17,Endocytosis; Endocrine and other factor-regulated calcium reabsorption; Synaptic vesicle cycle; Huntington's disease,Synaptic Vesicle Pathway; EGF/EGFR Signaling Pathway,"Cargo recognition for clathrin-mediated endocytosis; Nef Mediated CD8 Down-regulation; Nef Mediated CD4 Down-regulation; Trafficking of GluR2-containing AMPA receptors; Recycling pathway of L1; LDL clearance; EPH-ephrin mediated repulsion of cells; Retrograde neurotrophin signalling; VLDLR internalisation and degradation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; MHC class II antigen presentation; WNT5A-dependent internalization of FZD4",48,High,1
P31150,Rab GDP dissociation inhibitor alpha OS=Homo sapiens OX=9606 GN=GDI1 PE=1 SV=2,0,295.794,60,26,789,15,447,50.6,5.14,378883,16.9,23,7,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;Golgi,catalytic activity;enzyme regulator activity;protein binding,Pf00996,2664,ENSG00000203879.11,GDI1,X,,Integrated Breast Cancer Pathway,RAB GEFs exchange GTP for GDP on RABs; Rho GTPase cycle,8,High,1
P21912,"Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Homo sapiens OX=9606 GN=SDHB PE=1 SV=3",0,294.843,46,28,1826,28,280,31.6,8.76,872998,13.55,27,6,metabolic process;transport,membrane;mitochondrion,catalytic activity;metal ion binding;protein binding,"Pf13085, Pf13183, Pf13534",6390,ENSG00000117118.9,SDHB,1,Carbon metabolism; Non-alcoholic fatty liver disease (NAFLD); Alzheimer's disease; Huntington's disease; Citrate cycle (TCA cycle); Metabolic pathways; Oxidative phosphorylation; Parkinson's disease,Electron Transport Chain; TCA Cycle,Respiratory electron transport; Citric acid cycle (TCA cycle),16,High,1
A7E2Y1,Myosin-7B OS=Homo sapiens OX=9606 GN=MYH7B PE=1 SV=4,0,294.7,6,26,4019,1,1983,225.7,6.09,1765685,757.56,23,8,metabolic process,membrane,catalytic activity;motor activity;nucleotide binding;protein binding,"Pf00063, Pf01576, Pf02736, Pf04111, Pf04156",57644,ENSG00000078814.15,MYH7B,20,Tight junction,,,1,High,1
Q6NVY1,"3-hydroxyisobutyryl-CoA hydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=HIBCH PE=1 SV=2",0,294.607,50,32,870,32,386,43.5,8.19,432225,0,32,2,metabolic process,mitochondrion;organelle lumen,catalytic activity,"Pf00378, Pf13766",26275,ENSG00000198130.15,HIBCH,2,"Carbon metabolism; Metabolic pathways; Propanoate metabolism; beta-Alanine metabolism; Valine, leucine and isoleucine degradation",Amino Acid metabolism,Branched-chain amino acid catabolism,9,High,1
Q8N142,Adenylosuccinate synthetase isozyme 1 OS=Homo sapiens OX=9606 GN=ADSS1 PE=1 SV=1,0,293.796,55,21,591,20,457,50.2,8.59,283807,94.74,19,9,metabolic process;response to stimulus,cytoplasm;cytosol,catalytic activity;metal ion binding;nucleotide binding;protein binding,Pf00709,122622,ENSG00000185100.10,ADSSL1,14,"Alanine, aspartate and glutamate metabolism; Metabolic pathways; Purine metabolism",,Purine ribonucleoside monophosphate biosynthesis,7,High,1
Q9Y2D5-6,Isoform 4 of A-kinase anchor protein 2 OS=Homo sapiens OX=9606 GN=AKAP2,0,293.331,47,37,301,33,1090,120.6,5.05,134621,33.62,33,4,regulation of biological process,membrane,,,445815; 114299; 11217,ENSG00000157654.17,PALM2-AKAP2; PALM2; AKAP2,9,,G Protein Signaling Pathways,,1,High,1
Q15772,Striated muscle preferentially expressed protein kinase OS=Homo sapiens OX=9606 GN=SPEG PE=1 SV=4,0,293.259,19,42,316,42,3267,354.1,8.51,66391,412.98,14,32,cell differentiation;metabolic process;regulation of biological process,nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00047, Pf00069, Pf01108, Pf07679, Pf07686, Pf07714, Pf13895, Pf13927",10290,ENSG00000072195.14,SPEG,2,,,,0,High,1
P06753,Tropomyosin alpha-3 chain OS=Homo sapiens OX=9606 GN=TPM3 PE=1 SV=2,0,292.909,56,32,3873,7,285,32.9,4.72,2105705,61.85,32,7,cell organization and biogenesis;cellular component movement,cytoplasm;cytoskeleton;cytosol,protein binding;structural molecule activity,"Pf00261, Pf12718",7170,ENSG00000143549.19,TPM3,1,Adrenergic signaling in cardiomyocytes; Cardiac muscle contraction; Dilated cardiomyopathy; Hypertrophic cardiomyopathy (HCM); Thyroid cancer; Pathways in cancer,Striated Muscle Contraction,Smooth Muscle Contraction; Striated Muscle Contraction,10,High,1
P35241,Radixin OS=Homo sapiens OX=9606 GN=RDX PE=1 SV=1,0,292.117,40,29,1538,13,583,68.5,6.37,786762,0,29,4,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;membrane,protein binding;RNA binding,"Pf00373, Pf00769, Pf09379, Pf09380",5962,ENSG00000137710.14,RDX,11,Regulation of actin cytoskeleton; Proteoglycans in cancer; MicroRNAs in cancer,Regulation of Actin Cytoskeleton,Recycling pathway of L1,8,High,1
P22033,"Methylmalonyl-CoA mutase, mitochondrial OS=Homo sapiens OX=9606 GN=MMUT PE=1 SV=4",0,292.016,43,28,663,28,750,83.1,6.93,312161,0,28,1,metabolic process,mitochondrion;organelle lumen,catalytic activity;metal ion binding,"Pf01642, Pf02310",4594,ENSG00000146085.7,MUT,6,"Glyoxylate and dicarboxylate metabolism; Propanoate metabolism; Metabolic pathways; Valine, leucine and isoleucine degradation; Carbon metabolism",Vitamin B12 Metabolism; Amino Acid metabolism,"Cobalamin (Cbl, vitamin B12) transport and metabolism; Defective MMAA causes methylmalonic aciduria type cblA; Propionyl-CoA catabolism; Defective MUT causes methylmalonic aciduria mut type",21,High,1
O94826,Mitochondrial import receptor subunit TOM70 OS=Homo sapiens OX=9606 GN=TOMM70 PE=1 SV=1,0,291.795,45,23,498,23,608,67.4,7.12,247477,6.05,22,2,cell communication;metabolic process;response to stimulus;transport,membrane;mitochondrion,protein binding;transporter activity,"Pf00515, Pf07719, Pf13414, Pf13424",9868,ENSG00000154174.7,TOMM70A; TOMM70,3,,,Ub-specific processing proteases; Mitochondrial protein import; Pink/Parkin Mediated Mitophagy,7,High,1
Q9NTK5,Obg-like ATPase 1 OS=Homo sapiens OX=9606 GN=OLA1 PE=1 SV=2,0,290.586,68,26,763,26,396,44.7,7.81,352837,23.6,25,3,metabolic process;transport,cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf01926, Pf02421, Pf06071",29789,ENSG00000138430.15,OLA1,2,,,Platelet degranulation,4,High,1
P45974,Ubiquitin carboxyl-terminal hydrolase 5 OS=Homo sapiens OX=9606 GN=USP5 PE=1 SV=2,0,290.431,48,35,468,33,858,95.7,5.03,230004,1.62,34,3,metabolic process;regulation of biological process,cytosol;vacuole,catalytic activity;metal ion binding;protein binding,"Pf00443, Pf00627, Pf02148, Pf13423",8078,ENSG00000111667.13,USP5,12,,,Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Ub-specific processing proteases,6,High,1
P28838,Cytosol aminopeptidase OS=Homo sapiens OX=9606 GN=LAP3 PE=1 SV=3,0,290.19,58,28,841,28,519,56.1,7.93,388142,6.65,25,6,metabolic process,cytoplasm;cytosol;mitochondrion;nucleus,catalytic activity;metal ion binding,"Pf00883, Pf02789",51056,ENSG00000002549.12,LAP3,4,Glutathione metabolism; Metabolic pathways; Arginine and proline metabolism,,,3,High,1
P39059,Collagen alpha-1(XV) chain OS=Homo sapiens OX=9606 GN=COL15A1 PE=1 SV=2,0,289.955,20,25,912,25,1388,141.6,5,447952,17.21,25,6,cell differentiation;development;metabolic process;regulation of biological process;response to stimulus,extracellular;organelle lumen,structural molecule activity,"Pf06482, Pf13385",1306,ENSG00000204291.10,COL15A1,9,Protein digestion and absorption,,Collagen degradation; Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization,8,High,1
P41252,"Isoleucine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=IARS PE=1 SV=2",0,289.792,42,43,394,43,1262,144.4,6.15,174273,4.28,42,2,cell differentiation;metabolic process;regulation of biological process,cytoplasm;cytosol;membrane,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00133, Pf01406, Pf08264, Pf09334",3376,ENSG00000196305.17,IARS,9,Aminoacyl-tRNA biosynthesis,Amino Acid metabolism,Cytosolic tRNA aminoacylation; SeMet incorporation into proteins,10,High,1
P47897,Glutamine--tRNA ligase OS=Homo sapiens OX=9606 GN=QARS PE=1 SV=1,0,288.583,51,36,506,34,775,87.7,7.15,225891,2.77,35,3,metabolic process;regulation of biological process,cytoplasm;cytosol;organelle lumen,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding,"Pf00749, Pf03950, Pf04557, Pf04558",5859,ENSG00000172053.17,QARS,3,Metabolic pathways; Aminoacyl-tRNA biosynthesis,,Mitochondrial tRNA aminoacylation; Cytosolic tRNA aminoacylation; SeMet incorporation into proteins,11,High,1
Q99714,3-hydroxyacyl-CoA dehydrogenase type-2 OS=Homo sapiens OX=9606 GN=HSD17B10 PE=1 SV=3,0,288.37,76,20,1149,20,261,26.9,7.78,550719,0,20,3,cell organization and biogenesis;metabolic process,cytoplasm;membrane;mitochondrion;organelle lumen,catalytic activity;protein binding;RNA binding,"Pf00106, Pf08659, Pf13561",3028,ENSG00000072506.12,HSD17B10,X,"Valine, leucine and isoleucine degradation; Metabolic pathways; Alzheimer's disease",Alzheimers Disease; Valproic acid pathway; Tryptophan metabolism,tRNA processing in the mitochondrion; rRNA processing in the mitochondrion; Branched-chain amino acid catabolism; tRNA modification in the mitochondrion,15,High,1
P50454,Serpin H1 OS=Homo sapiens OX=9606 GN=SERPINH1 PE=1 SV=2,0,288.156,55,24,520,24,418,46.4,8.69,248185,5.74,24,3,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;endoplasmic reticulum;membrane;organelle lumen,enzyme regulator activity;protein binding;RNA binding,Pf00079,871,ENSG00000149257.13,SERPINH1,11,,Endochondral Ossification,Collagen biosynthesis and modifying enzymes,4,High,1
P04844,Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 OS=Homo sapiens OX=9606 GN=RPN2 PE=1 SV=3,0,287.318,58,27,466,27,631,69.2,5.69,235989,0,27,1,metabolic process;response to stimulus,endoplasmic reticulum;membrane,catalytic activity;protein binding,Pf05817,6185,ENSG00000118705.16,RPN2,20,Metabolic pathways; N-Glycan biosynthesis; Protein processing in endoplasmic reticulum,Proteasome Degradation,Asparagine N-linked glycosylation; SRP-dependent cotranslational protein targeting to membrane,9,High,1
P15121,Aldo-keto reductase family 1 member B1 OS=Homo sapiens OX=9606 GN=AKR1B1 PE=1 SV=3,0,287.256,75,30,1444,28,316,35.8,6.98,708587,43.42,27,5,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;extracellular;vacuole,catalytic activity;protein binding,Pf00248,231,ENSG00000085662.13,AKR1B1,7,Fructose and mannose metabolism; Metabolic pathways; Glycerolipid metabolism; Pentose and glucuronate interconversions; Galactose metabolism,Polyol Pathway; Metapathway biotransformation,Pregnenolone biosynthesis; Fructose biosynthesis,15,High,1
P22830,"Ferrochelatase, mitochondrial OS=Homo sapiens OX=9606 GN=FECH PE=1 SV=2",0,287.2,48,23,523,23,423,47.8,8.73,261658,36.24,23,2,metabolic process;response to stimulus,membrane;mitochondrion;organelle lumen,catalytic activity;metal ion binding;protein binding,Pf00762,2235,ENSG00000066926.10,FECH,18,Metabolic pathways; Porphyrin and chlorophyll metabolism,Heme Biosynthesis,Heme biosynthesis,6,High,1
Q9UQ90,Paraplegin OS=Homo sapiens OX=9606 GN=SPG7 PE=1 SV=2,0,287.014,40,28,481,28,795,88.2,8.69,218603,22.39,28,4,cell organization and biogenesis;cellular component movement;metabolic process;response to stimulus;transport,membrane;mitochondrion,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00004, Pf01078, Pf01434, Pf05496, Pf06068, Pf07724, Pf07728",6687,ENSG00000197912.14,SPG7,16,,,Processing of SMDT1,3,High,1
P04083,Annexin A1 OS=Homo sapiens OX=9606 GN=ANXA1 PE=1 SV=2,0,286.893,63,26,746,26,346,38.7,7.02,386006,2.62,25,4,cell differentiation;cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;cytoskeleton;cytosol;endosome;extracellular;membrane;nucleus;vacuole,catalytic activity;DNA binding;enzyme regulator activity;metal ion binding;protein binding;RNA binding;structural molecule activity,Pf00191,301,ENSG00000135046.13,ANXA1,9,,Integrated Breast Cancer Pathway; Spinal Cord Injury; VEGFA-VEGFR2 Signaling Pathway; Prostaglandin Synthesis and Regulation,Gastrin-CREB signalling pathway via PKC and MAPK; G alpha (i) signalling events; Smooth Muscle Contraction; Interleukin-4 and 13 signaling; Formyl peptide receptors bind formyl peptides and many other ligands,20,High,1
Q9UPQ0,LIM and calponin homology domains-containing protein 1 OS=Homo sapiens OX=9606 GN=LIMCH1 PE=1 SV=4,0,286.511,43,41,350,8,1083,121.8,6.47,151428,8.06,40,2,cell organization and biogenesis,,metal ion binding;protein binding,"Pf00307, Pf00412",22998,ENSG00000064042.17,LIMCH1,4,,,,0,High,1
Q05707,Collagen alpha-1(XIV) chain OS=Homo sapiens OX=9606 GN=COL14A1 PE=1 SV=3,0,286.256,32,43,343,43,1796,193.4,5.3,143617,0,43,3,cell organization and biogenesis,extracellular;organelle lumen,protein binding;RNA binding;structural molecule activity,"Pf00041, Pf00092, Pf01391, Pf13519",7373,ENSG00000187955.11,COL14A1,8,Protein digestion and absorption,,Collagen degradation; Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization,8,High,1
Q9Y697,"Cysteine desulfurase, mitochondrial OS=Homo sapiens OX=9606 GN=NFS1 PE=1 SV=3",0,286.231,63,24,547,24,457,50.2,8.31,263938,9.95,24,1,cell organization and biogenesis;metabolic process,cytoplasm;cytosol;mitochondrion;nucleus;organelle lumen,catalytic activity;metal ion binding;protein binding,"Pf00266, Pf01212",9054,ENSG00000244005.12,NFS1,20,Metabolic pathways; Sulfur relay system; Thiamine metabolism,,Mitochondrial iron-sulfur cluster biogenesis,5,High,1
P31939,Bifunctional purine biosynthesis protein PURH OS=Homo sapiens OX=9606 GN=ATIC PE=1 SV=3,0,286.192,62,35,581,35,592,64.6,6.71,284761,2.1,34,1,metabolic process;response to stimulus,cytosol;membrane;mitochondrion,catalytic activity;protein binding,"Pf01808, Pf02142",471,ENSG00000138363.14,ATIC,2,Metabolic pathways; Antifolate resistance; One carbon pool by folate; Purine metabolism,One Carbon Metabolism,Purine ribonucleoside monophosphate biosynthesis,9,High,1
Q92499,ATP-dependent RNA helicase DDX1 OS=Homo sapiens OX=9606 GN=DDX1 PE=1 SV=2,0,285.105,42,29,748,28,740,82.4,7.23,342819,1.76,29,3,cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding,"Pf00270, Pf00271, Pf00622",1653,ENSG00000079785.14,DDX1,2,,DDX1 as a regulatory component of the Drosha microprocessor; mRNA Processing,tRNA processing in the nucleus,5,High,1
P22626,Heterogeneous nuclear ribonucleoproteins A2/B1 OS=Homo sapiens OX=9606 GN=HNRNPA2B1 PE=1 SV=2,0,284.982,62,25,808,23,353,37.4,8.95,383944,1.65,25,3,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;extracellular;membrane;nucleus;spliceosomal complex,DNA binding;protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",3181,ENSG00000122566.20,HNRNPA2B1,7,,mRNA Processing,Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Interleukin-12 family signaling; mRNA Splicing - Major Pathway,10,High,1
Q16531,DNA damage-binding protein 1 OS=Homo sapiens OX=9606 GN=DDB1 PE=1 SV=1,0,284.977,37,39,573,39,1140,126.9,5.26,269186,0,39,4,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,DNA binding;protein binding,"Pf03178, Pf10433",1642,ENSG00000167986.13,DDB1,11,Ubiquitin mediated proteolysis; Viral carcinogenesis; Nucleotide excision repair; Hepatitis B,,Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual incision in TC-NER; Formation of TC-NER Pre-Incision Complex; Dual Incision in GG-NER; Neddylation,19,High,1
Q9Y277-2,Isoform 2 of Voltage-dependent anion-selective channel protein 3 OS=Homo sapiens OX=9606 GN=VDAC3,0,284.72,59,27,2667,1,284,30.8,8.66,1172324,55.96,24,5,cell communication;defense response;regulation of biological process;response to stimulus;transport,membrane;mitochondrion;nucleus,nucleotide binding;transporter activity,Pf01459,7419,ENSG00000078668.13,VDAC3,8,,,,0,High,1
Q07065,Cytoskeleton-associated protein 4 OS=Homo sapiens OX=9606 GN=CKAP4 PE=1 SV=2,0,284.489,56,28,437,28,602,66,5.92,207884,4.29,28,2,metabolic process;transport,cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;organelle lumen,RNA binding,Pf13166,10970,ENSG00000136026.13,CKAP4,12,Protein processing in endoplasmic reticulum,,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Surfactant metabolism; Neutrophil degranulation,9,High,1
P53618,Coatomer subunit beta OS=Homo sapiens OX=9606 GN=COPB1 PE=1 SV=3,0,283.969,42,32,359,32,953,107.1,6.05,162797,0,32,1,transport,cytoplasm;cytosol;Golgi;membrane,protein binding;structural molecule activity,"Pf01602, Pf07718, Pf14806",1315,ENSG00000129083.12,COPB1,11,,,COPI-dependent Golgi-to-ER retrograde traffic; Neutrophil degranulation; COPI-mediated anterograde transport,14,High,1
P80404,"4-aminobutyrate aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=ABAT PE=1 SV=3",0,283.966,53,24,629,24,500,56.4,7.96,299915,3.26,23,3,metabolic process;regulation of biological process;response to stimulus,mitochondrion;organelle lumen,catalytic activity;metal ion binding;protein binding,"Pf00202, Pf13481",18,ENSG00000183044.11,ABAT,16,"GABAergic synapse; Propanoate metabolism; Valine, leucine and isoleucine degradation; Alanine, aspartate and glutamate metabolism; Butanoate metabolism; Metabolic pathways; beta-Alanine metabolism",Alanine and aspartate metabolism; Valproic acid pathway,Degradation of GABA,14,High,1
Q12906,Interleukin enhancer-binding factor 3 OS=Homo sapiens OX=9606 GN=ILF3 PE=1 SV=3,0,283.777,50,35,427,32,894,95.3,8.76,182569,1.67,35,2,defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;extracellular;membrane;mitochondrion;nucleus,DNA binding;protein binding;RNA binding,"Pf00035, Pf07528, Pf14709",3609,ENSG00000129351.17,ILF3,19,,,,0,High,1
Q9P0J1,"[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial OS=Homo sapiens OX=9606 GN=PDP1 PE=1 SV=3",0,283.366,57,23,609,23,537,61,6.67,276882,5.18,22,5,metabolic process;regulation of biological process,mitochondrion;organelle lumen,catalytic activity;metal ion binding;protein binding,Pf00481,54704,ENSG00000164951.15,PDP1,8,,,Regulation of pyruvate dehydrogenase (PDH) complex,5,High,1
P48147,Prolyl endopeptidase OS=Homo sapiens OX=9606 GN=PREP PE=1 SV=2,0,283.298,45,28,412,28,710,80.6,5.86,197132,,28,,metabolic process,cytoplasm;cytosol;membrane;nucleus,catalytic activity;protein binding,"Pf00326, Pf02897",5550,ENSG00000085377.13,PREP,6,Renin-angiotensin system,,,1,High,1
P29144,Tripeptidyl-peptidase 2 OS=Homo sapiens OX=9606 GN=TPP2 PE=1 SV=4,0,283.144,37,39,373,39,1249,138.3,6.32,161835,0,39,1,metabolic process,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,"Pf00082, Pf12580, Pf13739",7174,ENSG00000134900.11,TPP2,13,,,Antigen processing: Ubiquitination & Proteasome degradation,4,High,1
P23141,Liver carboxylesterase 1 OS=Homo sapiens OX=9606 GN=CES1 PE=1 SV=2,0,282.491,59,32,652,30,567,62.5,6.6,317100,0,31,2,cell differentiation;metabolic process;response to stimulus,cytosol;endoplasmic reticulum;organelle lumen,catalytic activity,"Pf00135, Pf00756, Pf07859, Pf12695",1066,ENSG00000198848.12,CES1,16,Metabolic pathways; Drug metabolism - other enzymes,"Phase I biotransformations, non P450; Fluoropyrimidine Activity; Irinotecan Pathway; NRF2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling",Phase I - Functionalization of compounds,10,High,1
P09104,Gamma-enolase OS=Homo sapiens OX=9606 GN=ENO2 PE=1 SV=3,0,281.483,55,25,610,12,434,47.2,5.03,297380,22.96,24,4,metabolic process,cytoplasm;cytosol;membrane,catalytic activity;metal ion binding;protein binding,"Pf00113, Pf03952, Pf13378",2026,ENSG00000111674.8,ENO2,12,Biosynthesis of amino acids; Carbon metabolism; RNA degradation; HIF-1 signaling pathway; Metabolic pathways; Glycolysis / Gluconeogenesis,Glycolysis and Gluconeogenesis,Gluconeogenesis; Glycolysis,12,High,1
O95810,Caveolae-associated protein 2 OS=Homo sapiens OX=9606 GN=CAVIN2 PE=1 SV=3,0,281.281,56,25,750,25,425,47.1,5.21,388325,3.68,24,4,cell organization and biogenesis,cytoplasm;cytosol;membrane,protein binding,Pf15237,8436,ENSG00000168497.4,SDPR; CAVIN2,2,,,,0,High,1
P02538,"Keratin, type II cytoskeletal 6A OS=Homo sapiens OX=9606 GN=KRT6A PE=1 SV=3",0,281.086,50,39,952,6,564,60,8,474164,10.78,39,4,cell death;cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,cytosol;membrane;nucleus,protein binding;structural molecule activity,"Pf00038, Pf04111, Pf13166",3853,ENSG00000205420.10,KRT6A,12,,Ectoderm Differentiation,Formation of the cornified envelope,4,High,1
O00748,Cocaine esterase OS=Homo sapiens OX=9606 GN=CES2 PE=1 SV=1,0,280.848,47,21,627,19,559,61.8,6.1,306287,0,21,1,metabolic process,endoplasmic reticulum;organelle lumen,catalytic activity,"Pf00135, Pf00326, Pf00756, Pf07859, Pf10340",8824,,CES2,16,Drug metabolism - other enzymes,"Phase I biotransformations, non P450; Fluoropyrimidine Activity; Irinotecan Pathway; NRF2 pathway",Phase I - Functionalization of compounds,8,High,1
Q08257,Quinone oxidoreductase OS=Homo sapiens OX=9606 GN=CRYZ PE=1 SV=1,0,280.634,64,21,746,21,329,35.2,8.44,376876,7.91,20,2,cell organization and biogenesis;metabolic process,cytoplasm;cytosol,catalytic activity;metal ion binding;nucleotide binding;RNA binding,"Pf00107, Pf08240, Pf13602",1429,ENSG00000116791.13,CRYZ,1,,,,0,High,1
Q8NB12,Histone-lysine N-methyltransferase SMYD1 OS=Homo sapiens OX=9606 GN=SMYD1 PE=1 SV=1,0,279.221,45,19,1037,19,490,56.6,7.09,443092,203.79,14,12,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;nucleus,catalytic activity;DNA binding;metal ion binding;protein binding,"Pf00856, Pf01753",150572,ENSG00000115593.14,SMYD1,2,,Heart Development; Histone Modifications,,2,High,1
Q9Y2Q3,Glutathione S-transferase kappa 1 OS=Homo sapiens OX=9606 GN=GSTK1 PE=1 SV=3,0,279.003,72,20,1192,20,226,25.5,8.41,592389,2.08,20,4,cell differentiation;metabolic process,membrane;mitochondrion;organelle lumen,antioxidant activity;catalytic activity;protein binding,Pf01323,373156,ENSG00000197448.13,GSTK1,7,Glutathione metabolism; Drug metabolism - cytochrome P450; Peroxisome; Metabolism of xenobiotics by cytochrome P450; Chemical carcinogenesis,Metapathway biotransformation,Glutathione conjugation,10,High,1
P23381,"Tryptophan--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=WARS PE=1 SV=2",0,278.291,52,26,670,26,471,53.1,6.23,326441,1.99,26,1,metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding,"Pf00458, Pf00579",7453,ENSG00000140105.17,WARS,14,Aminoacyl-tRNA biosynthesis,Photodynamic therapy-induced unfolded protein response; Amino Acid metabolism; Tryptophan metabolism,Cytosolic tRNA aminoacylation,8,High,1
O75947,"ATP synthase subunit d, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5PD PE=1 SV=3",0,277.309,82,29,2584,29,161,18.5,5.3,1302539,124.62,29,4,cell organization and biogenesis;metabolic process;transport,cytosol;membrane;mitochondrion,catalytic activity;transporter activity,Pf05873,10476,ENSG00000167863.11,ATP5H,17,Parkinson's disease; Oxidative phosphorylation; Metabolic pathways; Alzheimer's disease; Huntington's disease,Electron Transport Chain; Oxidative phosphorylation,Cristae formation; Formation of ATP by chemiosmotic coupling,14,High,1
P12270,Nucleoprotein TPR OS=Homo sapiens OX=9606 GN=TPR PE=1 SV=3,0,276.655,26,47,201,47,2363,267.1,5.02,89953,,47,,cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,chromosome;cytoplasm;cytoskeleton;membrane;nucleus,catalytic activity;motor activity;protein binding;RNA binding;structural molecule activity;transporter activity,"Pf00038, Pf01496, Pf01576, Pf02463, Pf03961, Pf04111, Pf05911, Pf07888, Pf07926, Pf09726, Pf12128, Pf13166, Pf13514",7175,ENSG00000047410.13,TPR,1,RNA transport; Thyroid cancer; Pathways in cancer,,Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins,69,High,1
O00231,26S proteasome non-ATPase regulatory subunit 11 OS=Homo sapiens OX=9606 GN=PSMD11 PE=1 SV=3,0,275.677,68,29,609,29,422,47.4,6.48,297488,0,29,1,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen;proteasome,catalytic activity;protein binding;structural molecule activity,Pf01399,5717,ENSG00000108671.9,PSMD11,17,Epstein-Barr virus infection; Proteasome,Proteasome Degradation; Parkin-Ubiquitin Proteasomal System pathway,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Neutrophil degranulation; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,153,High,1
P67936-2,Isoform 2 of Tropomyosin alpha-4 chain OS=Homo sapiens OX=9606 GN=TPM4,0,275.517,41,27,4298,1,284,32.7,4.73,2302948,49.51,24,8,cell differentiation;cell organization and biogenesis;cellular component movement,cytoskeleton;cytosol;membrane,metal ion binding;protein binding;structural molecule activity,"Pf00261, Pf12718",7171,ENSG00000167460.14,TPM4,19,,Striated Muscle Contraction,,1,High,1
P14735,Insulin-degrading enzyme OS=Homo sapiens OX=9606 GN=IDE PE=1 SV=4,0,274.85,39,39,392,39,1019,117.9,6.61,163272,1.84,39,3,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cell surface;cytoplasm;cytosol;extracellular;membrane;mitochondrion;nucleus;organelle lumen;proteasome,catalytic activity;metal ion binding;nucleotide binding;protein binding;receptor activity,"Pf00675, Pf05193",3416,ENSG00000119912.15,IDE,10,Alzheimer's disease,Alzheimers Disease,Ub-specific processing proteases,6,High,1
P32119,Peroxiredoxin-2 OS=Homo sapiens OX=9606 GN=PRDX2 PE=1 SV=5,0,274.614,77,29,1788,21,198,21.9,5.97,983499,76.93,27,6,cell communication;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,antioxidant activity;catalytic activity;protein binding,"Pf00578, Pf08534, Pf10417",7001,ENSG00000167815.11,PRDX2,19,,Selenium Micronutrient Network,TP53 Regulates Metabolic Genes; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Detoxification of Reactive Oxygen Species,12,High,1
P09874,Poly [ADP-ribose] polymerase 1 OS=Homo sapiens OX=9606 GN=PARP1 PE=1 SV=4,0,274.184,43,35,320,35,1014,113,8.88,132012,0,35,2,cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,membrane;mitochondrion;nucleus,catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding,"Pf00533, Pf00644, Pf00645, Pf02877, Pf05406, Pf08063",142,ENSG00000143799.12,PARP1,1,NF-kappa B signaling pathway; Apoptosis; Base excision repair,"Corticotropin-releasing hormone signaling pathway; Nanoparticle triggered regulated necrosis; Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways",POLB-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Formation of Incision Complex in GG-NER; Downregulation of SMAD2/3:SMAD4 transcriptional activity; DNA Damage Recognition in GG-NER; HDR through MMEJ (alt-NHEJ); SUMOylation of DNA damage response and repair proteins,35,High,1
Q9UBQ7,Glyoxylate reductase/hydroxypyruvate reductase OS=Homo sapiens OX=9606 GN=GRHPR PE=1 SV=1,0,273.811,56,22,745,22,328,35.6,7.39,375952,43.65,19,5,cell organization and biogenesis;metabolic process,cytoplasm;cytosol;organelle lumen,catalytic activity;nucleotide binding;protein binding,"Pf00389, Pf01488, Pf02826, Pf03446, Pf03807",9380,ENSG00000137106.17,GRHPR,9,"Glycine, serine and threonine metabolism; Metabolic pathways; Glyoxylate and dicarboxylate metabolism; Pyruvate metabolism",,Glyoxylate metabolism and glycine degradation,7,High,1
O14773,Tripeptidyl-peptidase 1 OS=Homo sapiens OX=9606 GN=TPP1 PE=1 SV=2,0,273.801,36,32,923,32,563,61.2,6.48,468164,4.15,32,3,cell differentiation;cell organization and biogenesis;metabolic process,mitochondrion;organelle lumen;vacuole,catalytic activity;metal ion binding;protein binding,Pf09286,1200,ENSG00000166340.15,TPP1,11,Lysosome,,XBP1(S) activates chaperone genes,5,High,1
P04275,von Willebrand factor OS=Homo sapiens OX=9606 GN=VWF PE=1 SV=4,0,272.759,17,39,374,39,2813,309.1,5.48,168398,2.34,38,2,cell organization and biogenesis;coagulation;metabolic process;response to stimulus;transport,endoplasmic reticulum;extracellular;organelle lumen,protein binding,"Pf00092, Pf00093, Pf00094, Pf01826, Pf08742",7450,ENSG00000110799.13,VWF,12,Complement and coagulation cascades; ECM-receptor interaction; PI3K-Akt signaling pathway; Platelet activation; Focal adhesion,Blood Clotting Cascade; Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Complement and Coagulation Cascades,Integrin cell surface interactions; Signaling by BRAF and RAF fusions; MAP2K and MAPK activation; Intrinsic Pathway of Fibrin Clot Formation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Platelet Adhesion to exposed collagen; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; GP1b-IX-V activation signalling; Signaling by moderate kinase activity BRAF mutants; p130Cas linkage to MAPK signaling for integrins; Platelet degranulation ; Paradoxical activation of RAF signaling by kinase inactive BRAF; Interleukin-20 family signaling,41,High,1
P23634,Plasma membrane calcium-transporting ATPase 4 OS=Homo sapiens OX=9606 GN=ATP2B4 PE=1 SV=2,0,271.498,30,31,374,4,1241,137.8,6.6,169579,,31,,cellular component movement;cellular homeostasis;regulation of biological process;response to stimulus;transport,membrane,catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding;transporter activity,"Pf00122, Pf00689, Pf00690, Pf00702, Pf08282, Pf12424, Pf12710, Pf13246",493,,ATP2B4,1,Adrenergic signaling in cardiomyocytes; Pancreatic secretion; Salivary secretion; cAMP signaling pathway; cGMP-PKG signaling pathway; Calcium signaling pathway,,Ion homeostasis; Reduction of cytosolic Ca++ levels; Ion transport by P-type ATPases,16,High,1
Q9BSJ8,Extended synaptotagmin-1 OS=Homo sapiens OX=9606 GN=ESYT1 PE=1 SV=1,0,269.398,37,29,304,29,1104,122.8,5.83,141468,0,29,1,metabolic process;transport,endoplasmic reticulum;membrane,metal ion binding;protein binding,Pf00168,23344,ENSG00000139641.12,ESYT1,12,,,Glycosphingolipid metabolism,4,High,1
O75955,Flotillin-1 OS=Homo sapiens OX=9606 GN=FLOT1 PE=1 SV=3,0,269.395,65,24,468,24,427,47.3,7.49,223690,1.67,24,2,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoskeleton;endosome;membrane,protein binding,Pf01145,10211,ENSG00000206379.12; ENSG00000230143.9; ENSG00000137312.14; ENSG00000206480.11; ENSG00000232280.9,FLOT1,6; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_COX_CTG1,Insulin signaling pathway,Angiopoietin Like Protein 8 Regulatory Pathway; Insulin Signaling,Synaptic adhesion-like molecules,6,High,1
Q96KP4,Cytosolic non-specific dipeptidase OS=Homo sapiens OX=9606 GN=CNDP2 PE=1 SV=2,0,269.155,58,24,487,24,475,52.8,5.97,237534,0,24,1,metabolic process,cytoplasm;cytosol,catalytic activity;metal ion binding,"Pf01546, Pf07687",55748,ENSG00000133313.14,CNDP2,18,Histidine metabolism; Arginine and proline metabolism; beta-Alanine metabolism; Metabolic pathways,,Glutathione synthesis and recycling,9,High,1
Q9UI09,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 OS=Homo sapiens OX=9606 GN=NDUFA12 PE=1 SV=1,0,268.801,79,20,2232,20,145,17.1,9.63,1132718,10.77,19,7,cell organization and biogenesis;metabolic process;response to stimulus;transport,cytosol;membrane;mitochondrion,catalytic activity,Pf05071,55967,ENSG00000184752.12,NDUFA12,12,Metabolic pathways; Huntington's disease; Oxidative phosphorylation; Parkinson's disease; Non-alcoholic fatty liver disease (NAFLD); Alzheimer's disease,Electron Transport Chain,Complex I biogenesis,12,High,1
Q9UIQ6,Leucyl-cystinyl aminopeptidase OS=Homo sapiens OX=9606 GN=LNPEP PE=1 SV=3,0,268.623,38,31,374,31,1025,117.3,5.73,169337,0,31,2,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytosol;extracellular;membrane;organelle lumen,catalytic activity;metal ion binding;protein binding,"Pf01433, Pf11838, Pf13485",4012,ENSG00000113441.15,LNPEP,5,Renin-angiotensin system,,Translocation of GLUT4 to the plasma membrane; Antigen processing: Ubiquitination & Proteasome degradation; Endosomal/Vacuolar pathway,10,High,1
O94973,AP-2 complex subunit alpha-2 OS=Homo sapiens OX=9606 GN=AP2A2 PE=1 SV=2,0,268.217,40,28,460,23,939,103.9,6.96,215539,0,28,1,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;membrane,protein binding;transporter activity,"Pf01602, Pf02296, Pf02883, Pf13646",161,ENSG00000183020.13,AP2A2,11,Endocrine and other factor-regulated calcium reabsorption; Endocytosis; Synaptic vesicle cycle; Huntington's disease,Synaptic Vesicle Pathway,"Cargo recognition for clathrin-mediated endocytosis; Nef Mediated CD8 Down-regulation; Nef Mediated CD4 Down-regulation; Recycling pathway of L1; LDL clearance; EPH-ephrin mediated repulsion of cells; Neutrophil degranulation; Retrograde neurotrophin signalling; VLDLR internalisation and degradation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; MHC class II antigen presentation; WNT5A-dependent internalization of FZD4",43,High,1
P04259,"Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5",0,268.078,49,38,942,6,564,60,8,472884,10.78,38,4,cell death;cell organization and biogenesis;metabolic process,cytosol,catalytic activity;motor activity;protein binding;structural molecule activity,"Pf00038, Pf01576, Pf04111, Pf13166",3854,ENSG00000185479.5,KRT6B,12,,,Formation of the cornified envelope,3,High,1
Q5VYK3,Proteasome adapter and scaffold protein ECM29 OS=Homo sapiens OX=9606 GN=ECPAS PE=1 SV=2,0,267.484,29,41,398,41,1845,204.2,7.12,163044,0,41,3,cell organization and biogenesis;metabolic process,cytoplasm;cytoskeleton;endoplasmic reticulum;endosome;membrane;nucleus;proteasome,protein binding;structural molecule activity,"Pf12755, Pf13001",23392,,KIAA0368,9,,,,0,High,1
P01031,Complement C5 OS=Homo sapiens OX=9606 GN=C5 PE=1 SV=4,0,267.395,28,40,369,40,1676,188.2,6.52,157622,0,40,2,cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus,extracellular,enzyme regulator activity;protein binding,"Pf00207, Pf01759, Pf01821, Pf01835, Pf07677, Pf07678, Pf07703, Pf11974",727,ENSG00000106804.7,C5,9,Staphylococcus aureus infection; Prion diseases; Systemic lupus erythematosus; Pertussis; Herpes simplex infection; Complement and coagulation cascades,Allograft Rejection; Spinal Cord Injury; Oxidative Damage; Complement Activation,Terminal pathway of complement; Peptide ligand-binding receptors; Regulation of Complement cascade; Activation of C3 and C5; G alpha (i) signalling events,23,High,1
Q14008,Cytoskeleton-associated protein 5 OS=Homo sapiens OX=9606 GN=CKAP5 PE=1 SV=3,0,267.339,29,49,291,49,2032,225.4,7.8,118552,0,49,1,cell division;cell organization and biogenesis;regulation of biological process;transport,chromosome;cytoplasm;cytoskeleton;cytosol;membrane,protein binding,Pf12348,9793,ENSG00000175216.14,CKAP5,11,,,Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins,28,High,1
Q93052,Lipoma-preferred partner OS=Homo sapiens OX=9606 GN=LPP PE=1 SV=1,0,266.798,51,26,517,25,612,65.7,7.37,259492,,26,,,cytoplasm;cytosol;membrane;nucleus,metal ion binding;protein binding,"Pf00412, Pf02318, Pf03154",4026,ENSG00000145012.13,LPP,3,,,,0,High,1
Q86UT6,NLR family member X1 OS=Homo sapiens OX=9606 GN=NLRX1 PE=1 SV=1,0,266.196,40,28,495,28,975,107.5,7.37,244139,45.39,25,7,defense response;regulation of biological process;response to stimulus,membrane;mitochondrion,nucleotide binding;protein binding,Pf05729,79671,ENSG00000160703.15,NLRX1,11,Influenza A; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway,RIG-I-like Receptor Signaling,Negative regulators of DDX58/IFIH1 signaling,8,High,1
P00738,Haptoglobin OS=Homo sapiens OX=9606 GN=HP PE=1 SV=1,0,266.171,53,30,1118,11,406,45.2,6.58,569364,123.1,26,8,defense response;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;organelle lumen,antioxidant activity;catalytic activity;protein binding,Pf00089,3240,ENSG00000257017.8,HP,16,,,Neutrophil degranulation; Scavenging of heme from plasma,6,High,1
Q9P2J5,"Leucine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=LARS PE=1 SV=2",0,266.09,42,38,360,38,1176,134.4,7.3,160511,,38,,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;vacuole,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding,"Pf00133, Pf01406, Pf08264, Pf09334",51520,ENSG00000133706.17,LARS,5,Aminoacyl-tRNA biosynthesis,,Cytosolic tRNA aminoacylation; SeMet incorporation into proteins,9,High,1
P50991,T-complex protein 1 subunit delta OS=Homo sapiens OX=9606 GN=CCT4 PE=1 SV=4,0,265.66,41,25,869,23,539,57.9,7.83,422500,0,25,3,metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol,nucleotide binding;protein binding;RNA binding,Pf00118,10575,ENSG00000115484.14,CCT4,2,,,BBSome-mediated cargo-targeting to cilium; Prefoldin mediated transfer of substrate  to CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Formation of tubulin folding intermediates by CCT/TriC; Folding of actin by CCT/TriC,13,High,1
O60716,Catenin delta-1 OS=Homo sapiens OX=9606 GN=CTNND1 PE=1 SV=1,0,265.033,41,28,261,28,968,108.1,6.23,124918,0,28,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,protein binding,Pf00514,1500,ENSG00000198561.13,CTNND1,11,Leukocyte transendothelial migration; Rap1 signaling pathway; Adherens junction,VEGFA-VEGFR2 Signaling Pathway; Wnt Signaling Pathway and Pluripotency,VEGFR2 mediated vascular permeability; Adherens junctions interactions; InlA-mediated entry of Listeria monocytogenes into host cells,18,High,1
Q9Y277,Voltage-dependent anion-selective channel protein 3 OS=Homo sapiens OX=9606 GN=VDAC3 PE=1 SV=1,0,264.128,59,27,2664,1,283,30.6,8.66,1172324,40.72,24,5,cell communication;defense response;regulation of biological process;response to stimulus;transport,membrane;mitochondrion;nucleus,nucleotide binding;transporter activity,Pf01459,7419,ENSG00000078668.13,VDAC3,8,Hepatitis B; Calcium signaling pathway; Viral carcinogenesis; HTLV-I infection; cGMP-PKG signaling pathway; NOD-like receptor signaling pathway; Parkinson's disease; Huntington's disease,,Mitochondrial calcium ion transport; Ub-specific processing proteases,14,High,1
Q14195-2,Isoform LCRMP-4 of Dihydropyrimidinase-related protein 3 OS=Homo sapiens OX=9606 GN=DPYSL3,0,263.977,51,26,525,21,684,73.9,6.35,249672,5.61,25,2,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytosol,catalytic activity;protein binding,"Pf01979, Pf13147, Pf13594",1809,ENSG00000113657.12,DPYSL3,5,,,,0,High,1
Q8WUF5,RelA-associated inhibitor OS=Homo sapiens OX=9606 GN=PPP1R13L PE=1 SV=4,0,263.263,51,30,362,30,828,89,6.81,170492,,30,,cell death;metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,protein binding,"Pf00018, Pf00023, Pf07653, Pf12796, Pf13606, Pf13637, Pf13857, Pf14604",10848,ENSG00000104881.15,PPP1R13L,19,,,Regulation of TP53 Activity through Association with Co-factors,6,High,1
Q99623,Prohibitin-2 OS=Homo sapiens OX=9606 GN=PHB2 PE=1 SV=2,0,262.748,64,25,1379,25,299,33.3,9.83,735596,7.47,25,8,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;membrane;mitochondrion;nucleus,protein binding,Pf01145,11331,ENSG00000215021.8,PHB2,12,,,Processing of SMDT1,3,High,1
O43852,Calumenin OS=Homo sapiens OX=9606 GN=CALU PE=1 SV=2,0,261.236,65,21,417,6,315,37.1,4.64,199368,0,21,1,metabolic process,endoplasmic reticulum;extracellular;Golgi;membrane;organelle lumen,metal ion binding;protein binding,Pf13499,813,ENSG00000128595.16,CALU,7,,NOTCH1 regulation of human endothelial cell calcification,Platelet degranulation ; Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs),9,High,1
P38117,Electron transfer flavoprotein subunit beta OS=Homo sapiens OX=9606 GN=ETFB PE=1 SV=3,0,260.945,75,24,2905,24,255,27.8,8.1,1497497,70.79,22,6,metabolic process;transport,cytosol;mitochondrion;organelle lumen,protein binding,Pf01012,2109,ENSG00000105379.9,ETFB,19,,,Protein methylation; Respiratory electron transport,7,High,1
P23368,"NAD-dependent malic enzyme, mitochondrial OS=Homo sapiens OX=9606 GN=ME2 PE=1 SV=1",0,260.31,50,25,643,25,584,65.4,7.61,287980,20.29,24,5,metabolic process;regulation of biological process,mitochondrion;organelle lumen,catalytic activity;metal ion binding;nucleotide binding,"Pf00390, Pf03949",4200,ENSG00000082212.12,ME2,18,Carbon metabolism; Pyruvate metabolism,,,2,High,1
P13010,X-ray repair cross-complementing protein 5 OS=Homo sapiens OX=9606 GN=XRCC5 PE=1 SV=3,0,260.124,44,29,546,29,732,82.7,5.81,243947,0,29,3,cell differentiation;cell organization and biogenesis;cell proliferation;defense response;metabolic process;regulation of biological process;response to stimulus;transport,chromosome;cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen,catalytic activity;DNA binding;enzyme regulator activity;nucleotide binding;protein binding;RNA binding,"Pf02735, Pf03730, Pf03731, Pf08785",7520,ENSG00000079246.15,XRCC5,2,Non-homologous end-joining,Non-homologous end joining,2-LTR circle formation; Neutrophil degranulation; IRF3-mediated induction of type I IFN; Nonhomologous End-Joining (NHEJ),18,High,1
P45880,Voltage-dependent anion-selective channel protein 2 OS=Homo sapiens OX=9606 GN=VDAC2 PE=1 SV=2,0,259.506,62,27,1955,24,294,31.5,7.56,971757,149.78,24,5,regulation of biological process;transport,membrane;mitochondrion;nucleus,nucleotide binding;protein binding;transporter activity,Pf01459,7417,ENSG00000165637.13,VDAC2,10,HTLV-I infection; NOD-like receptor signaling pathway; Parkinson's disease; cGMP-PKG signaling pathway; Calcium signaling pathway; Huntington's disease,,Mitochondrial calcium ion transport; Ub-specific processing proteases,12,High,1
Q9UIJ7,"GTP:AMP phosphotransferase AK3, mitochondrial OS=Homo sapiens OX=9606 GN=AK3 PE=1 SV=4",0,259.453,85,26,1708,25,227,25.6,9.16,882757,4.07,26,4,coagulation;metabolic process,mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding,"Pf00406, Pf05191, Pf13207, Pf13238, Pf13671",50808,ENSG00000147853.16,AK3,9,Purine metabolism,,Factors involved in megakaryocyte development and platelet production,3,High,1
P32418,Sodium/calcium exchanger 1 OS=Homo sapiens OX=9606 GN=SLC8A1 PE=1 SV=3,0,259.073,29,24,615,23,973,108.5,5,291787,34.75,23,6,cell communication;cellular homeostasis;regulation of biological process;response to stimulus;transport,membrane;mitochondrion,metal ion binding;protein binding;transporter activity,"Pf01699, Pf03160",6546,ENSG00000183023.18,SLC8A1,2,Endocrine and other factor-regulated calcium reabsorption; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Cardiac muscle contraction; cGMP-PKG signaling pathway; Calcium signaling pathway; Protein digestion and absorption; Olfactory transduction; Hypertrophic cardiomyopathy (HCM); Dilated cardiomyopathy; Mineral absorption; Adrenergic signaling in cardiomyocytes,Arrhythmogenic Right Ventricular Cardiomyopathy; Myometrial Relaxation and Contraction Pathways; VEGFA-VEGFR2 Signaling Pathway; Calcium Regulation in the Cardiac Cell,Ion homeostasis; Reduction of cytosolic Ca++ levels; Sodium/Calcium exchangers,26,High,1
O14980,Exportin-1 OS=Homo sapiens OX=9606 GN=XPO1 PE=1 SV=1,0,258.65,33,33,397,33,1071,123.3,6.06,175580,0,33,3,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,chromosome;cytoplasm;cytosol;membrane;nucleus,protein binding;RNA binding;transporter activity,"Pf03810, Pf08389, Pf08767",7514,ENSG00000082898.16,XPO1,2,HTLV-I infection; Influenza A; Epstein-Barr virus infection; RNA transport; Ribosome biogenesis in eukaryotes,eIF5A regulation in response to inhibition of the nuclear export system,Rev-mediated nuclear export of HIV RNA; Downregulation of TGF-beta receptor signaling; NEP/NS2 Interacts with the Cellular Export Machinery; Cyclin A/B1/B2 associated events during G2/M transition; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Deactivation of the beta-catenin transactivating complex; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; HuR (ELAVL1) binds and stabilizes mRNA; RHO GTPases Activate Formins; MAPK6/MAPK4 signaling,49,High,1
Q9UDR5,"Alpha-aminoadipic semialdehyde synthase, mitochondrial OS=Homo sapiens OX=9606 GN=AASS PE=1 SV=1",0,258.304,37,29,681,29,926,102.1,6.64,321490,15.65,28,7,cell organization and biogenesis;metabolic process,mitochondrion;organelle lumen,catalytic activity,"Pf01262, Pf03435, Pf05222",10157,ENSG00000008311.14,AASS,7,Lysine degradation; Metabolic pathways,,Lysine catabolism,6,High,1
P26640,Valine--tRNA ligase OS=Homo sapiens OX=9606 GN=VARS PE=1 SV=4,0,257.272,29,33,260,33,1264,140.4,7.59,122127,0,33,2,metabolic process;regulation of biological process,cytoplasm;cytosol;mitochondrion,catalytic activity;nucleotide binding;protein binding,"Pf00043, Pf00133, Pf08264, Pf09334, Pf13603",7407; 57176,ENSG00000096171.14; ENSG00000204394.12; ENSG00000226589.9,VARS; VARS2,6; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_COX_CTG1,Aminoacyl-tRNA biosynthesis,Amino Acid metabolism,Cytosolic tRNA aminoacylation,6,High,1
O00330,"Pyruvate dehydrogenase protein X component, mitochondrial OS=Homo sapiens OX=9606 GN=PDHX PE=1 SV=3",0,257.077,51,26,925,26,501,54.1,8.66,490122,10.49,25,4,metabolic process;regulation of biological process,mitochondrion;organelle lumen,catalytic activity;protein binding,"Pf00198, Pf00364, Pf02817",8050,ENSG00000110435.11,PDHX,11,Metabolic pathways,Amino Acid metabolism; Glycolysis and Gluconeogenesis,Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Glyoxylate metabolism and glycine degradation,13,High,1
Q14240,Eukaryotic initiation factor 4A-II OS=Homo sapiens OX=9606 GN=EIF4A2 PE=1 SV=2,0,256.541,60,30,707,14,407,46.4,5.48,341868,0,30,1,metabolic process;regulation of biological process,cytosol,catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding,"Pf00270, Pf00271, Pf04851",1974,ENSG00000156976.16,EIF4A2,3,RNA transport,Translation Factors,ISG15 antiviral mechanism; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Deadenylation of mRNA; Ribosomal scanning and start codon recognition,19,High,1
Q6P2Q9,Pre-mRNA-processing-splicing factor 8 OS=Homo sapiens OX=9606 GN=PRPF8 PE=1 SV=2,0,256.162,26,49,239,49,2335,273.4,8.84,103488,0,49,1,cell organization and biogenesis;metabolic process;response to stimulus,membrane;nucleus;spliceosomal complex,catalytic activity;protein binding;RNA binding,"Pf01398, Pf08082, Pf08083, Pf08084, Pf10596, Pf10597, Pf10598, Pf12134",10594,ENSG00000174231.16; ENSG00000274442.2,PRPF8,17; CHR_HSCHR17_1_CTG2,Spliceosome,mRNA Processing,mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway,7,High,1
P55290,Cadherin-13 OS=Homo sapiens OX=9606 GN=CDH13 PE=1 SV=1,0,256.077,32,19,819,19,713,78.2,4.98,383368,200.5,17,9,cell organization and biogenesis;cell proliferation;cellular component movement;regulation of biological process;response to stimulus,cytoplasm;extracellular;membrane,metal ion binding;protein binding,"Pf00028, Pf08758",1012,ENSG00000140945.16,CDH13,16,,,Adherens junctions interactions,4,High,1
O60237,Protein phosphatase 1 regulatory subunit 12B OS=Homo sapiens OX=9606 GN=PPP1R12B PE=1 SV=2,0,255.739,36,32,561,22,982,110.3,5.67,256409,115.29,27,12,regulation of biological process;response to stimulus,cytoplasm;cytosol,enzyme regulator activity;protein binding,"Pf00023, Pf12796, Pf13606, Pf13637, Pf13857",4660,ENSG00000077157.21,PPP1R12B,1,Vascular smooth muscle contraction; Proteoglycans in cancer; Oxytocin signaling pathway; Regulation of actin cytoskeleton; Focal adhesion,,RHO GTPases activate PAKs; RHO GTPases Activate ROCKs; RHO GTPases activate PKNs; RHO GTPases activate CIT,12,High,1
P50995,Annexin A11 OS=Homo sapiens OX=9606 GN=ANXA11 PE=1 SV=1,0,255.599,34,23,967,22,505,54.4,7.65,505024,4.77,22,4,cell division;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane;nucleus;vacuole,metal ion binding;protein binding;RNA binding,Pf00191,311,ENSG00000122359.17,ANXA11,10,,,,0,High,1
P26440,"Isovaleryl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=IVD PE=1 SV=2",0,255.075,54,25,821,25,426,46.6,8.05,391625,6.04,25,3,,,,,,,,,,,,0,High,1
P13667,Protein disulfide-isomerase A4 OS=Homo sapiens OX=9606 GN=PDIA4 PE=1 SV=2,0,254.771,48,30,412,30,645,72.9,5.07,182986,4.81,30,3,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;endoplasmic reticulum;organelle lumen,catalytic activity;metal ion binding;protein binding;RNA binding,"Pf00085, Pf01216, Pf13098, Pf13848, Pf13905",9601,ENSG00000155660.10,PDIA4,7,Protein processing in endoplasmic reticulum; Thyroid hormone synthesis; Vibrio cholerae infection,,,3,High,1
P00568,Adenylate kinase isoenzyme 1 OS=Homo sapiens OX=9606 GN=AK1 PE=1 SV=3,0,253.517,73,22,1491,22,194,21.6,8.63,782201,21.81,21,3,metabolic process,cytoplasm;cytosol,catalytic activity;nucleotide binding,"Pf00406, Pf06414, Pf13207, Pf13238, Pf13671",203,ENSG00000106992.17,AK1,9,Thiamine metabolism; Metabolic pathways; Purine metabolism,,Interconversion of nucleotide di- and triphosphates,6,High,1
O75153,Clustered mitochondria protein homolog OS=Homo sapiens OX=9606 GN=CLUH PE=1 SV=2,0,253.386,34,33,285,33,1309,146.6,6.13,125980,,33,,cell organization and biogenesis,cytoplasm,protein binding;RNA binding,"Pf12807, Pf13236, Pf13374, Pf13424, Pf15044",23277,ENSG00000132361.16,CLUH; KIAA0664,17,,Translation Factors,,1,High,1
P49588,"Alanine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=AARS PE=1 SV=2",0,253.176,44,31,400,31,968,106.7,5.53,177419,,31,,metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;mitochondrion,catalytic activity;metal ion binding;nucleotide binding;RNA binding,"Pf01411, Pf02272, Pf07973",16,ENSG00000090861.15,AARS,16,Aminoacyl-tRNA biosynthesis,,Cytosolic tRNA aminoacylation,5,High,1
P10606,"Cytochrome c oxidase subunit 5B, mitochondrial OS=Homo sapiens OX=9606 GN=COX5B PE=1 SV=2",0,252.942,51,21,2355,21,129,13.7,8.81,1251058,9.19,21,4,metabolic process;transport,membrane;mitochondrion,catalytic activity;metal ion binding;protein binding;transporter activity,Pf01215,1329,ENSG00000135940.6,COX5B,2,Alzheimer's disease; Non-alcoholic fatty liver disease (NAFLD); Huntington's disease; Metabolic pathways; Oxidative phosphorylation; Parkinson's disease; Cardiac muscle contraction,Electron Transport Chain,TP53 Regulates Metabolic Genes; Respiratory electron transport,17,High,1
Q01995,Transgelin OS=Homo sapiens OX=9606 GN=TAGLN PE=1 SV=4,0,252.756,66,23,1650,23,201,22.6,8.84,793838,6.8,23,4,cell differentiation,cytoplasm,protein binding,"Pf00307, Pf00402",6876,ENSG00000149591.16,TAGLN,11,,,,0,High,1
O95140,Mitofusin-2 OS=Homo sapiens OX=9606 GN=MFN2 PE=1 SV=3,0,252.284,40,29,515,27,757,86.3,6.98,225760,18.89,27,6,cell communication;cell death;cell organization and biogenesis;coagulation;metabolic process;regulation of biological process;response to stimulus;transport,cytoskeleton;cytosol;membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding,"Pf00350, Pf01926, Pf04799",9927,ENSG00000116688.16,MFN2,1,NOD-like receptor signaling pathway,,Factors involved in megakaryocyte development and platelet production; Pink/Parkin Mediated Mitophagy,5,High,1
Q9UBC2,Epidermal growth factor receptor substrate 15-like 1 OS=Homo sapiens OX=9606 GN=EPS15L1 PE=1 SV=1,0,251.723,68,37,251,37,864,94.2,5.11,115701,0,37,1,cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;Golgi;membrane;nucleus,catalytic activity;metal ion binding;motor activity;nucleotide binding;protein binding;structural molecule activity;transporter activity,"Pf00038, Pf00261, Pf00529, Pf00769, Pf01496, Pf01576, Pf01920, Pf02050, Pf02321, Pf02463, Pf02841, Pf02994, Pf03148, Pf03962, Pf03999, Pf04012, Pf04111, Pf04156, Pf04912, Pf04977, Pf05103, Pf05149, Pf05262, Pf05276, Pf05478, Pf05483, Pf05557, Pf05622, Pf05667, Pf05701, Pf05816, Pf05957, Pf06008, Pf06160, Pf06818, Pf07111, Pf07321, Pf07798, Pf07888, Pf07926, Pf08317, Pf08614, Pf09311, Pf09726, Pf09730, Pf09731, Pf09755, Pf09787, Pf09789, Pf10146, Pf10168, Pf10174, Pf10186, Pf10211, Pf10234, Pf10359, Pf10498, Pf11180, Pf11559, Pf11932, Pf12072, Pf12128, Pf12325, Pf12329, Pf12718, Pf12763, Pf12795, Pf13094, Pf13166, Pf13514, Pf13779, Pf13851, Pf13863, Pf13868, Pf13870, Pf13949, Pf14073, Pf14362, Pf14662, Pf14772, Pf14817, Pf14915, Pf14932, Pf14988, Pf14992, Pf15035, Pf15070, Pf15272, Pf15346, Pf15397, Pf15450, Pf15619",58513,ENSG00000127527.13,EPS15L1,19,Endocytosis,EGF/EGFR Signaling Pathway,Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation,10,High,1
P61163,Alpha-centractin OS=Homo sapiens OX=9606 GN=ACTR1A PE=1 SV=1,0,251.492,59,17,449,9,376,42.6,6.64,200913,2.38,17,4,regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol,nucleotide binding;protein binding,Pf00022,10121,ENSG00000138107.12,ACTR1A,10,,,COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR),33,High,1
O75533,Splicing factor 3B subunit 1 OS=Homo sapiens OX=9606 GN=SF3B1 PE=1 SV=3,0,251.433,43,38,215,38,1304,145.7,7.09,93768,,38,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,nucleus;spliceosomal complex,DNA binding;protein binding;receptor activity;RNA binding;signal transducer activity,"Pf02161, Pf08920, Pf12815, Pf13513",23451,ENSG00000115524.15,SF3B1,2,Spliceosome,mRNA Processing,B-WICH complex positively regulates rRNA expression; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway,11,High,1
P30043,Flavin reductase (NADPH) OS=Homo sapiens OX=9606 GN=BLVRB PE=1 SV=3,0,251.293,77,21,1017,21,206,22.1,7.65,470917,6.04,20,3,metabolic process;transport,cytoplasm;cytosol;membrane,catalytic activity,"Pf01073, Pf01370, Pf02254, Pf13460",645,ENSG00000090013.9,BLVRB,19,Riboflavin metabolism; Porphyrin and chlorophyll metabolism,NRF2 pathway,Heme degradation,6,High,1
P13073,"Cytochrome c oxidase subunit 4 isoform 1, mitochondrial OS=Homo sapiens OX=9606 GN=COX4I1 PE=1 SV=1",0,251.076,62,22,2623,22,169,19.6,9.51,1344887,26.41,21,4,metabolic process;response to stimulus;transport,membrane;mitochondrion;nucleus,catalytic activity;protein binding;transporter activity,Pf02936,1327,ENSG00000131143.8,COX4I1,16,Huntington's disease; Oxidative phosphorylation; Metabolic pathways; Parkinson's disease; Cardiac muscle contraction; Non-alcoholic fatty liver disease (NAFLD); Alzheimer's disease,Electron Transport Chain,TP53 Regulates Metabolic Genes; Respiratory electron transport,17,High,1
P60842,Eukaryotic initiation factor 4A-I OS=Homo sapiens OX=9606 GN=EIF4A1 PE=1 SV=1,0,251.027,51,25,620,10,406,46.1,5.48,306551,0,25,1,metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding,"Pf00270, Pf00271, Pf04851",1973,ENSG00000161960.14,EIF4A1,17,RNA transport,Translation Factors; Interferon type I signaling pathways,ISG15 antiviral mechanism; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Deadenylation of mRNA; Ribosomal scanning and start codon recognition,20,High,1
Q96HY7,"Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial OS=Homo sapiens OX=9606 GN=DHTKD1 PE=1 SV=2",0,251.023,35,23,430,23,919,103,6.93,187203,0,23,1,cell differentiation;metabolic process,cytosol;mitochondrion;organelle lumen,catalytic activity,"Pf00676, Pf02779",55526,ENSG00000181192.11,DHTKD1,10,,Integrated Breast Cancer Pathway,Glyoxylate metabolism and glycine degradation,4,High,1
O75521,"Enoyl-CoA delta isomerase 2, mitochondrial OS=Homo sapiens OX=9606 GN=ECI2 PE=1 SV=4",0,250.814,55,19,1047,19,394,43.6,9,464028,127.19,16,8,metabolic process,membrane;mitochondrion;organelle lumen,catalytic activity;protein binding,"Pf00378, Pf00887",10455,ENSG00000198721.12,ECI2,6,Fatty acid degradation; Peroxisome,,,2,High,1
P02730,Band 3 anion transport protein OS=Homo sapiens OX=9606 GN=SLC4A1 PE=1 SV=3,0,250.281,29,24,526,24,911,101.7,5.19,248761,0,24,2,cellular homeostasis;transport,cytoskeleton;membrane,protein binding;transporter activity,"Pf00955, Pf07565",6521,ENSG00000004939.13,SLC4A1,17,Collecting duct acid secretion,,"Bicarbonate transporters; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide; Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4),  distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)",12,High,1
P43686,26S proteasome regulatory subunit 6B OS=Homo sapiens OX=9606 GN=PSMC4 PE=1 SV=2,0,250.045,75,29,430,29,418,47.3,5.21,193277,10.34,29,1,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus;proteasome,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00004, Pf00006, Pf00910, Pf01057, Pf01078, Pf05496, Pf07724, Pf07726, Pf07728, Pf13191",5704,ENSG00000281221.2; ENSG00000013275.7,PSMC4,19; CHR_HG2021_PATCH,Proteasome; Epstein-Barr virus infection,Proteasome Degradation; Parkin-Ubiquitin Proteasomal System pathway,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,152,High,1
P36542-2,"Isoform Heart of ATP synthase subunit gamma, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1C",0,249.638,54,24,2014,24,297,32.9,9.31,1019565,209.94,22,9,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion;organelle lumen,catalytic activity;RNA binding;transporter activity,Pf00231,509,ENSG00000165629.19,ATP5C1,10,,Electron Transport Chain,,1,High,1
O95822,"Malonyl-CoA decarboxylase, mitochondrial OS=Homo sapiens OX=9606 GN=MLYCD PE=1 SV=3",0,249.523,56,22,681,22,493,55,8.95,349260,60.91,19,7,metabolic process;regulation of biological process;response to stimulus,cytoplasm;mitochondrion;organelle lumen,catalytic activity;protein binding,Pf05292,23417,ENSG00000103150.5,MLYCD,16,AMPK signaling pathway; Propanoate metabolism; Metabolic pathways; beta-Alanine metabolism; Peroxisome,,Beta-oxidation of very long chain fatty acids,10,High,1
Q8NFV4,Protein ABHD11 OS=Homo sapiens OX=9606 GN=ABHD11 PE=1 SV=1,0,249.498,64,18,446,17,315,34.7,9.48,202814,0,18,1,,mitochondrion,catalytic activity,"Pf00561, Pf00756, Pf07819, Pf12695, Pf12697",83451,ENSG00000106077.18,ABHD11,7,,,,0,High,1
P50990,T-complex protein 1 subunit theta OS=Homo sapiens OX=9606 GN=CCT8 PE=1 SV=4,0,249.104,58,30,722,30,548,59.6,5.6,328978,8.94,29,12,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;extracellular;organelle lumen,catalytic activity;nucleotide binding;protein binding,Pf00118,10694,ENSG00000156261.12,CCT8,21,,,BBSome-mediated cargo-targeting to cilium; Prefoldin mediated transfer of substrate  to CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Neutrophil degranulation; Folding of actin by CCT/TriC; Formation of tubulin folding intermediates by CCT/TriC,16,High,1
Q9ULD0,"2-oxoglutarate dehydrogenase-like, mitochondrial OS=Homo sapiens OX=9606 GN=OGDHL PE=1 SV=3",0,248.849,22,30,901,9,1010,114.4,6.65,453484,17.94,29,3,metabolic process,cytosol;mitochondrion;organelle lumen,catalytic activity;metal ion binding;protein binding,"Pf00676, Pf02779",55753,ENSG00000197444.9,OGDHL,10,Carbon metabolism; Tryptophan metabolism; Lysine degradation; Citrate cycle (TCA cycle); Metabolic pathways,,,5,High,1
O75027,"ATP-binding cassette sub-family B member 7, mitochondrial OS=Homo sapiens OX=9606 GN=ABCB7 PE=1 SV=2",0,248.582,35,20,352,20,752,82.6,9.33,180070,3.08,20,2,cellular homeostasis;transport,membrane;mitochondrion,catalytic activity;nucleotide binding;transporter activity,"Pf00005, Pf00664, Pf13207, Pf13304",22,ENSG00000131269.15,ABCB7,X,ABC transporters,,Cytosolic iron-sulfur cluster assembly; Mitochondrial ABC transporters,6,High,1
Q9BXK5,Bcl-2-like protein 13 OS=Homo sapiens OX=9606 GN=BCL2L13 PE=1 SV=1,0,248.508,57,27,355,27,485,52.7,4.44,167074,2.59,27,2,cell death;metabolic process;regulation of biological process,membrane;mitochondrion;nucleus,enzyme regulator activity;protein binding,Pf00452,23786,ENSG00000099968.17,BCL2L13,22,Legionellosis,Regulation of Apoptosis by Parathyroid Hormone-related Protein,,2,High,1
Q9Y6M9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 OS=Homo sapiens OX=9606 GN=NDUFB9 PE=1 SV=3,0,246.85,63,22,912,22,179,21.8,8.38,468690,22.13,20,2,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion,catalytic activity;protein binding,"Pf05347, Pf13232",4715,ENSG00000147684.7,NDUFB9,8,Huntington's disease; Oxidative phosphorylation; Metabolic pathways; Parkinson's disease; Non-alcoholic fatty liver disease (NAFLD); Alzheimer's disease,Electron Transport Chain; Oxidative phosphorylation,Complex I biogenesis,13,High,1
Q16881-5,"Isoform 5 of Thioredoxin reductase 1, cytoplasmic OS=Homo sapiens OX=9606 GN=TXNRD1",0,246.741,52,21,448,21,499,54.7,6.47,224833,1.62,20,4,cell proliferation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cytosol;mitochondrion,antioxidant activity;catalytic activity;nucleotide binding;protein binding,"Pf00070, Pf02852, Pf07992, Pf13738",7296,ENSG00000198431.15,TXNRD1,12,,Selenium Micronutrient Network; Selenium Metabolism and Selenoproteins; NRF2 pathway; Oxidative Stress,,4,High,1
Q9BZL4,Protein phosphatase 1 regulatory subunit 12C OS=Homo sapiens OX=9606 GN=PPP1R12C PE=1 SV=1,0,246.505,49,30,244,2,782,84.8,5.57,121763,3.21,30,3,regulation of biological process;response to stimulus,cytoplasm,enzyme regulator activity;protein binding,"Pf00023, Pf12796, Pf13606, Pf13637, Pf13857",54776,ENSG00000125503.12,PPP1R12C,19,Regulation of actin cytoskeleton; Vascular smooth muscle contraction; Focal adhesion; Proteoglycans in cancer; Oxytocin signaling pathway,,,5,High,1
P40123,Adenylyl cyclase-associated protein 2 OS=Homo sapiens OX=9606 GN=CAP2 PE=1 SV=1,0,246.458,62,21,418,20,477,52.8,6.37,209140,12.58,20,4,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoskeleton;membrane,protein binding,"Pf01213, Pf07986, Pf08603",10486,ENSG00000112186.11,CAP2,6,,Ectoderm Differentiation; Aryl Hydrocarbon Receptor Pathway,Role of ABL in ROBO-SLIT signaling,6,High,1
Q9UPU5,Ubiquitin carboxyl-terminal hydrolase 24 OS=Homo sapiens OX=9606 GN=USP24 PE=1 SV=3,0,246.254,22,38,185,38,2620,294.2,6.14,78221,3.87,36,3,metabolic process,,catalytic activity;protein binding,"Pf00443, Pf13423",23358,ENSG00000162402.13,USP24,1,,,Ub-specific processing proteases,4,High,1
Q0ZGT2-2,Isoform 2 of Nexilin OS=Homo sapiens OX=9606 GN=NEXN,0,246.071,38,29,502,2,662,79.3,5.34,247152,44.16,26,8,regulation of biological process,cytoskeleton,protein binding;structural molecule activity,"Pf00047, Pf07679, Pf13895",91624,,NEXN,1,,,,0,High,1
Q0ZGT2,Nexilin OS=Homo sapiens OX=9606 GN=NEXN PE=1 SV=1,0,245.814,39,28,500,1,675,80.6,5.33,250132,25.99,27,6,regulation of biological process,cytoplasm;cytoskeleton,protein binding;structural molecule activity,"Pf00047, Pf07679, Pf13895",91624,ENSG00000162614.18,NEXN,1,,,,0,High,1
Q04637,Eukaryotic translation initiation factor 4 gamma 1 OS=Homo sapiens OX=9606 GN=EIF4G1 PE=1 SV=4,0,244.917,25,36,366,34,1599,175.4,5.33,162150,,36,,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,nucleotide binding;protein binding;RNA binding;structural molecule activity,"Pf00566, Pf02020, Pf02847, Pf02854",1981,ENSG00000114867.20,EIF4G1,3,Viral myocarditis; RNA transport,Translation Factors,ISG15 antiviral mechanism; mTORC1-mediated signalling; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Deadenylation of mRNA; Ribosomal scanning and start codon recognition; AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation,32,High,1
Q8WVM8,Sec1 family domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SCFD1 PE=1 SV=4,0,244.842,48,26,248,26,642,72.3,6.27,116559,0,26,2,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;Golgi;membrane,protein binding,Pf00995,23256,ENSG00000092108.20,SCFD1,14,,,COPII (Coat Protein 2) Mediated Vesicle Transport,8,High,1
P23634-2,Isoform XA of Plasma membrane calcium-transporting ATPase 4 OS=Homo sapiens OX=9606 GN=ATP2B4,0,244.459,28,28,338,1,1170,129.3,7.52,157061,5.45,27,1,cellular component movement;cellular homeostasis;regulation of biological process;response to stimulus;transport,membrane,catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding;transporter activity,"Pf00122, Pf00689, Pf00690, Pf00702, Pf08282, Pf12424, Pf12710, Pf13246",493,ENSG00000058668.14,ATP2B4,1,,,,0,High,1
Q13561,Dynactin subunit 2 OS=Homo sapiens OX=9606 GN=DCTN2 PE=1 SV=4,0,244.263,56,20,424,20,401,44.2,5.21,201265,0,20,2,cell organization and biogenesis;cell proliferation;regulation of biological process;transport,chromosome;cytoplasm;cytoskeleton;cytosol;membrane,catalytic activity;motor activity;protein binding,Pf04912,10540,ENSG00000175203.15,DCTN2,12,Huntington's disease; Vasopressin-regulated water reabsorption,,COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR),35,High,1
O00468-6,Isoform 6 of Agrin OS=Homo sapiens OX=9606 GN=AGRN,0,243.895,16,26,414,26,2045,214.7,6.4,187665,114.14,21,8,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytosol;extracellular;membrane;organelle lumen,metal ion binding;protein binding;structural molecule activity,"Pf00050, Pf00053, Pf00054, Pf01390, Pf02210, Pf03146, Pf07648",375790,ENSG00000188157.14,AGRN,1,ECM-receptor interaction,Primary Focal Segmental Glomerulosclerosis FSGS,,2,High,1
Q9UPQ0-3,Isoform 3 of LIM and calponin homology domains-containing protein 1 OS=Homo sapiens OX=9606 GN=LIMCH1,0,243.858,26,34,325,1,1467,164.3,6.27,130452,30.17,32,3,cell organization and biogenesis,,metal ion binding;protein binding,Pf00412,22998,,LIMCH1,4,,,,0,High,1
P10253,Lysosomal alpha-glucosidase OS=Homo sapiens OX=9606 GN=GAA PE=1 SV=4,0,243.349,35,25,344,24,952,105.3,6,151974,,25,,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,membrane;organelle lumen;vacuole,catalytic activity,"Pf00088, Pf01055, Pf13802",2548,ENSG00000171298.12,GAA,17,Lysosome; Starch and sucrose metabolism; Metabolic pathways; Galactose metabolism,,Neutrophil degranulation; Glycogen storage disease type II (GAA); Lysosomal glycogen catabolism; Glycogen breakdown (glycogenolysis),17,High,1
P09211,Glutathione S-transferase P OS=Homo sapiens OX=9606 GN=GSTP1 PE=1 SV=2,0,243.297,61,16,1064,16,210,23.3,5.64,551409,5.27,15,4,cell communication;cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;membrane;mitochondrion;nucleus;organelle lumen,antioxidant activity;catalytic activity;enzyme regulator activity;protein binding,"Pf00043, Pf02798, Pf14497",2950,ENSG00000084207.15,GSTP1,11,Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450; Chemical carcinogenesis; Pathways in cancer; Platinum drug resistance; Prostate cancer; Glutathione metabolism,NRF2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Exercise-induced Circadian Regulation; Arachidonate Epoxygenase / Epoxide Hydrolase; Metapathway biotransformation,Glutathione conjugation; Neutrophil degranulation; Detoxification of Reactive Oxygen Species,22,High,1
P23246,"Splicing factor, proline- and glutamine-rich OS=Homo sapiens OX=9606 GN=SFPQ PE=1 SV=2",0,242.847,37,26,674,25,707,76.1,9.44,317038,0,26,2,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;nucleus,DNA binding;protein binding;RNA binding,"Pf00076, Pf08075, Pf13893, Pf14259",6421,ENSG00000116560.10,SFPQ,1,,mRNA Processing,PTK6 Regulates Proteins Involved in RNA Processing,5,High,1
P40227,T-complex protein 1 subunit zeta OS=Homo sapiens OX=9606 GN=CCT6A PE=1 SV=3,0,241.956,46,24,490,16,531,58,6.68,233412,1.9,24,3,metabolic process;regulation of biological process,cytoplasm;cytosol;membrane,nucleotide binding;protein binding;RNA binding,"Pf00118, Pf05504",908,ENSG00000146731.10,CCT6A,7,,,Prefoldin mediated transfer of substrate  to CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Formation of tubulin folding intermediates by CCT/TriC; Folding of actin by CCT/TriC,9,High,1
P07099,Epoxide hydrolase 1 OS=Homo sapiens OX=9606 GN=EPHX1 PE=1 SV=1,0,241.554,62,29,624,29,455,52.9,7.25,275495,5.49,27,3,metabolic process;response to stimulus,endoplasmic reticulum;membrane,catalytic activity;protein binding,"Pf00561, Pf06441, Pf12697",2052,ENSG00000143819.12,EPHX1,1,Chemical carcinogenesis; Metabolism of xenobiotics by cytochrome P450; Bile secretion,Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Benzene metabolism; Benzo(a)pyrene metabolism; Aflatoxin B1 metabolism; Metapathway biotransformation,Phase I - Functionalization of compounds,11,High,1
Q13424,Alpha-1-syntrophin OS=Homo sapiens OX=9606 GN=SNTA1 PE=1 SV=1,0,240.865,55,17,617,15,505,53.9,6.8,262701,297.7,15,9,regulation of biological process,cytoplasm;cytoskeleton;membrane,protein binding;structural molecule activity,"Pf00169, Pf00595, Pf14685",6640,ENSG00000101400.5,SNTA1,20,,Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,,1,High,1
P62937,Peptidyl-prolyl cis-trans isomerase A OS=Homo sapiens OX=9606 GN=PPIA PE=1 SV=2,0,240.26,63,19,1111,19,165,18,7.81,513033,236.82,18,5,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen,catalytic activity;protein binding;RNA binding,Pf00160,5478,ENSG00000196262.13,PPIA,7,,Prolactin Signaling Pathway,Budding and maturation of HIV virion; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Minus-strand DNA synthesis; Binding and entry of HIV virion; Basigin interactions; APOBEC3G mediated resistance to HIV-1 infection; Uncoating of the HIV Virion; Calcineurin activates NFAT; Platelet degranulation ; Plus-strand DNA synthesis; Integration of provirus; Neutrophil degranulation; Assembly Of The HIV Virion; Interleukin-12 family signaling,34,High,1
P49257,Protein ERGIC-53 OS=Homo sapiens OX=9606 GN=LMAN1 PE=1 SV=2,0,240.225,44,19,300,19,510,57.5,6.77,142825,0,19,2,cell organization and biogenesis;coagulation;metabolic process;regulation of biological process;transport,endoplasmic reticulum;Golgi;membrane,metal ion binding;protein binding,Pf03388,3998,ENSG00000074695.5,LMAN1,18,Protein processing in endoplasmic reticulum,Complement and Coagulation Cascades,Cargo concentration in the ER; COPII (Coat Protein 2) Mediated Vesicle Transport,11,High,1
P54819,"Adenylate kinase 2, mitochondrial OS=Homo sapiens OX=9606 GN=AK2 PE=1 SV=2",0,240.187,64,20,820,20,239,26.5,7.81,390764,32.36,20,4,metabolic process,membrane;mitochondrion,catalytic activity;nucleotide binding,"Pf00406, Pf05191, Pf13207, Pf13671",204,ENSG00000004455.16,AK2,1,Thiamine metabolism; Metabolic pathways; Purine metabolism,,Interconversion of nucleotide di- and triphosphates,6,High,1
P62195,26S proteasome regulatory subunit 8 OS=Homo sapiens OX=9606 GN=PSMC5 PE=1 SV=1,0,239.792,59,25,395,24,406,45.6,7.55,183301,1.77,24,4,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus;proteasome,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00004, Pf00910, Pf01057, Pf01078, Pf05496, Pf06068, Pf06414, Pf07724, Pf07726, Pf07728, Pf13191, Pf13207, Pf13401",5705,ENSG00000087191.12,PSMC5,17,Epstein-Barr virus infection; Proteasome,Proteasome Degradation; Parkin-Ubiquitin Proteasomal System pathway,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,152,High,1
Q14BN4-5,Isoform 5 of Sarcolemmal membrane-associated protein OS=Homo sapiens OX=9606 GN=SLMAP,0,239.602,56,27,652,1,359,41.9,5.21,328923,55.01,25,5,cell organization and biogenesis;metabolic process;regulation of biological process,endoplasmic reticulum;membrane,protein binding,"Pf03961, Pf04111, Pf12128, Pf13166, Pf13514",7871,,SLMAP,3,,,,0,High,1
Q96RP9,"Elongation factor G, mitochondrial OS=Homo sapiens OX=9606 GN=GFM1 PE=1 SV=2",0,239.405,36,25,456,25,751,83.4,7.01,215211,2.4,25,2,metabolic process,mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00009, Pf00679, Pf03144, Pf03764, Pf14492",85476,ENSG00000168827.14,GFM1,3,,,Mitochondrial translation elongation,4,High,1
Q9Y678,Coatomer subunit gamma-1 OS=Homo sapiens OX=9606 GN=COPG1 PE=1 SV=1,0,239.373,33,24,283,23,874,97.7,5.47,135523,0,24,2,cellular component movement;transport,cytoplasm;cytosol;Golgi;membrane,protein binding;structural molecule activity,"Pf01602, Pf08752",22820,ENSG00000181789.14,COPG1,3,,,COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport,11,High,1
P10909,Clusterin OS=Homo sapiens OX=9606 GN=CLU PE=1 SV=1,0,239.001,44,21,428,21,449,52.5,6.27,221887,2.6,20,4,cell death;cell organization and biogenesis;cell proliferation;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;cytosol;endoplasmic reticulum;extracellular;Golgi;membrane;mitochondrion;nucleus;organelle lumen,catalytic activity;protein binding,Pf01093,1191,ENSG00000120885.21,CLU,8,Complement and coagulation cascades,Complement and Coagulation Cascades,Platelet degranulation ; Terminal pathway of complement; Antimicrobial peptides; Regulation of Complement cascade,12,High,1
Q8N766,ER membrane protein complex subunit 1 OS=Homo sapiens OX=9606 GN=EMC1 PE=1 SV=1,0,238.676,40,30,403,30,993,111.7,7.66,179352,0,30,1,metabolic process,endoplasmic reticulum;membrane,,"Pf07774, Pf13360",23065,ENSG00000127463.13,EMC1,1,,,,0,High,1
P16989,Y-box-binding protein 3 OS=Homo sapiens OX=9606 GN=YBX3 PE=1 SV=4,0,238.014,70,20,203,17,372,40.1,9.77,94286,111.97,18,2,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,DNA binding;protein binding;RNA binding,Pf00313,8531,ENSG00000060138.12,CSDA; YBX3,12,Tight junction,RalA downstream regulated genes; Apoptosis-related network due to altered Notch3 in ovarian cancer,,3,High,1
Q9NP74,Palmdelphin OS=Homo sapiens OX=9606 GN=PALMD PE=1 SV=1,0,237.697,61,25,357,24,551,62.7,5.44,171801,17.61,23,6,regulation of biological process,cytoplasm;membrane,,Pf03285,54873,ENSG00000099260.10,PALMD,1,,,,0,High,1
P17980,26S proteasome regulatory subunit 6A OS=Homo sapiens OX=9606 GN=PSMC3 PE=1 SV=3,0,237.336,57,20,442,20,439,49.2,5.24,219197,3.75,20,4,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen;proteasome,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding,"Pf00004, Pf01078, Pf05496, Pf07724, Pf07728, Pf13191",5702,ENSG00000165916.8,PSMC3,11,Proteasome; Epstein-Barr virus infection,Proteasome Degradation; Parkin-Ubiquitin Proteasomal System pathway,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Neutrophil degranulation; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,153,High,1
Q8N1G4,Leucine-rich repeat-containing protein 47 OS=Homo sapiens OX=9606 GN=LRRC47 PE=1 SV=1,0,236.846,44,23,436,23,583,63.4,8.28,220824,0,23,1,metabolic process,,catalytic activity;protein binding;RNA binding,"Pf03483, Pf12799, Pf13855",57470,ENSG00000130764.9,LRRC47,1,,,,0,High,1
P43490,Nicotinamide phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=NAMPT PE=1 SV=1,0,236.535,54,22,499,22,491,55.5,7.15,231473,0,22,2,cell communication;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;extracellular;nucleus,catalytic activity;protein binding,Pf04095,10135,ENSG00000105835.11,NAMPT,7,NOD-like receptor signaling pathway; Nicotinate and nicotinamide metabolism; Metabolic pathways,"Adipogenesis; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways","BMAL1:CLOCK,NPAS2 activates circadian gene expression; Nicotinamide salvaging",14,High,1
P67936,Tropomyosin alpha-4 chain OS=Homo sapiens OX=9606 GN=TPM4 PE=1 SV=3,0,235.922,47,23,4149,4,248,28.5,4.69,2229960,36.3,22,5,cell differentiation;cell organization and biogenesis;cellular component movement,cytoplasm;cytoskeleton;cytosol;membrane,metal ion binding;protein binding;structural molecule activity,"Pf00261, Pf12718",7171,ENSG00000167460.14,TPM4,19,Hypertrophic cardiomyopathy (HCM); Dilated cardiomyopathy; Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes,Striated Muscle Contraction,Smooth Muscle Contraction; Striated Muscle Contraction,8,High,1
Q13724,Mannosyl-oligosaccharide glucosidase OS=Homo sapiens OX=9606 GN=MOGS PE=1 SV=5,0,235.686,45,30,287,29,837,91.9,8.9,130258,,30,,metabolic process,endoplasmic reticulum;membrane,catalytic activity,Pf03200,7841,ENSG00000115275.11,MOGS,2,N-Glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum,,Defective MOGS causes MOGS-CDG (CDG-2b); N-glycan trimming in the ER and Calnexin/Calreticulin cycle,11,High,1
Q86VP6,Cullin-associated NEDD8-dissociated protein 1 OS=Homo sapiens OX=9606 GN=CAND1 PE=1 SV=2,0,235.686,26,31,469,29,1230,136.3,5.78,211213,1.66,31,2,cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;extracellular;Golgi;membrane;nucleus;organelle lumen,protein binding,"Pf08623, Pf12755, Pf13513",55832,ENSG00000111530.12,CAND1,12,,Endoderm Differentiation,Neutrophil degranulation; Iron uptake and transport; Neddylation,9,High,1
Q86W92,Liprin-beta-1 OS=Homo sapiens OX=9606 GN=PPFIBP1 PE=1 SV=2,0,235.584,36,33,279,30,1011,114,5.55,117632,,33,,cell organization and biogenesis;metabolic process,cytosol;membrane,protein binding,"Pf00536, Pf04111, Pf05483, Pf05911, Pf07647",8496,ENSG00000110841.13,PPFIBP1,12,,,Receptor-type tyrosine-protein phosphatases,3,High,1
Q9BZL4-3,Isoform 3 of Protein phosphatase 1 regulatory subunit 12C OS=Homo sapiens OX=9606 GN=PPP1R12C,0,235.296,49,29,245,1,780,84.6,5.57,120332,8.9,28,4,regulation of biological process;response to stimulus,cytoplasm,enzyme regulator activity;protein binding,"Pf00023, Pf12796, Pf13606, Pf13637, Pf13857",54776,,PPP1R12C,19,,,,0,High,1
P62805,Histone H4 OS=Homo sapiens OX=9606 GN=H4C1 PE=1 SV=2,0,234.756,59,23,2544,23,103,11.4,11.36,1374813,10.45,23,4,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;extracellular;membrane;nucleus,DNA binding;protein binding;RNA binding,"Pf00125, Pf02969, Pf15630",8359; 8361; 8360; 8363; 8370; 554313; 8365; 8364; 121504; 8367; 8294; 8366; 8362; 8368,ENSG00000197061.4; ENSG00000275126.1; ENSG00000273542.1; ENSG00000197238.4; ENSG00000197837.3; ENSG00000276966.2; ENSG00000158406.4; ENSG00000270882.2; ENSG00000274618.1; ENSG00000278637.1; ENSG00000277157.1; ENSG00000278705.1; ENSG00000270276.2; ENSG00000276180.1,HIST1H4A; HIST1H4F; HIST1H4D; HIST1H4J; HIST2H4A; HIST2H4B; HIST1H4H; HIST1H4C; HIST4H4; HIST1H4E; HIST1H4I; HIST1H4B; HIST1H4K; HIST1H4L,6; 1; 12,Viral carcinogenesis; Systemic lupus erythematosus; Alcoholism,Gastric Cancer Network 1; Histone Modifications; Type II interferon signaling (IFNG),SIRT1 negatively regulates rRNA expression; RMTs methylate histone arginines; Nonhomologous End-Joining (NHEJ); Activation of anterior HOX genes in hindbrain development during early embryogenesis; NoRC negatively regulates rRNA expression; Meiotic synapsis; Transcriptional regulation by small RNAs; Meiotic recombination; PRC2 methylates histones and DNA; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; HDACs deacetylate histones; Formation of the beta-catenin:TCF transactivating complex; DNA methylation; G2/M DNA damage checkpoint; Packaging Of Telomere Ends; Amyloid fiber formation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RNA Polymerase I Chain Elongation; HDMs demethylate histones; PKMTs methylate histone lysines; HATs acetylate histones; Deposition of new CENPA-containing nucleosomes at the centromere; SUMOylation of chromatin organization proteins; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Condensation of Prophase Chromosomes; Processing of DNA double-strand break ends; DNA Damage/Telomere Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); B-WICH complex positively regulates rRNA expression; RNA Polymerase I Promoter Opening; Oxidative Stress Induced Senescence,82,High,1
Q02127,"Dihydroorotate dehydrogenase (quinone), mitochondrial OS=Homo sapiens OX=9606 GN=DHODH PE=1 SV=3",0,234.715,70,25,288,25,395,42.8,9.67,141753,0,25,1,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;mitochondrion,catalytic activity;nucleotide binding,Pf01180,1723,ENSG00000102967.11,DHODH,16,Metabolic pathways; Pyrimidine metabolism,,Pyrimidine biosynthesis,6,High,1
Q9H2U2,"Inorganic pyrophosphatase 2, mitochondrial OS=Homo sapiens OX=9606 GN=PPA2 PE=1 SV=2",0,234.629,57,22,628,21,334,37.9,7.39,279814,0,22,2,metabolic process,cytoplasm;mitochondrion;organelle lumen,catalytic activity;metal ion binding,Pf00719,27068,ENSG00000138777.19,PPA2,4,Oxidative phosphorylation,,Mitochondrial tRNA aminoacylation; Pyrophosphate hydrolysis,7,High,1
Q9UBY9,Heat shock protein beta-7 OS=Homo sapiens OX=9606 GN=HSPB7 PE=1 SV=1,0,234.565,75,16,1192,16,170,18.6,6.52,508126,115.89,15,7,regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;mitochondrion;nucleus,protein binding,Pf00011,27129,ENSG00000173641.17,HSPB7,1,,Differentiation of white and brown adipocyte,,1,High,1
P51687,"Sulfite oxidase, mitochondrial OS=Homo sapiens OX=9606 GN=SUOX PE=1 SV=2",0,234.404,46,17,340,17,545,60.2,6.11,161475,11.62,17,4,metabolic process,mitochondrion;organelle lumen,catalytic activity;metal ion binding;protein binding,"Pf00173, Pf00174, Pf03404",6821,ENSG00000139531.12,SUOX,12,Sulfur metabolism,,Sulfide oxidation to sulfate,6,High,1
P23297,Protein S100-A1 OS=Homo sapiens OX=9606 GN=S100A1 PE=1 SV=2,0,233.524,56,13,1460,13,94,10.5,4.5,730155,84.39,11,3,regulation of biological process;response to stimulus,cytoplasm;endoplasmic reticulum;extracellular;nucleus,metal ion binding;protein binding,Pf01023,6271,ENSG00000160678.11,S100A1,1,,,Regulation of TLR by endogenous ligand,4,High,1
Q14BN4,Sarcolemmal membrane-associated protein OS=Homo sapiens OX=9606 GN=SLMAP PE=1 SV=1,0,233.522,24,27,648,1,828,95.1,5.47,329939,37.17,26,4,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;endoplasmic reticulum;membrane,protein binding;transporter activity,"Pf00498, Pf01496, Pf01920, Pf02463, Pf03961, Pf04111, Pf05262, Pf05483, Pf05701, Pf07888, Pf12128, Pf13166, Pf13514",7871,ENSG00000163681.14,SLMAP,3,,,,0,High,1
P35237,Serpin B6 OS=Homo sapiens OX=9606 GN=SERPINB6 PE=1 SV=3,0,233.503,70,20,849,19,376,42.6,5.27,416815,0,20,2,regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;membrane;nucleus,enzyme regulator activity;protein binding,Pf00079,5269,ENSG00000124570.17,SERPINB6,6,Amoebiasis,Ectoderm Differentiation,Dissolution of Fibrin Clot; Neutrophil degranulation,7,High,1
O00571,ATP-dependent RNA helicase DDX3X OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=3,0,233.221,49,30,451,28,662,73.2,7.18,208104,0,30,1,cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;membrane;mitochondrion;nucleus;organelle lumen,catalytic activity;DNA binding;enzyme regulator activity;nucleotide binding;protein binding;RNA binding,"Pf00270, Pf00271, Pf04851",1654,ENSG00000215301.9,DDX3X,X,Hepatitis B; RIG-I-like receptor signaling pathway; Viral carcinogenesis,RIG-I-like Receptor Signaling,Neutrophil degranulation,7,High,1
Q9Y4E8,Ubiquitin carboxyl-terminal hydrolase 15 OS=Homo sapiens OX=9606 GN=USP15 PE=1 SV=3,0,233.064,43,34,186,32,981,112.3,5.22,89542,0,34,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;mitochondrion;nucleus,catalytic activity;protein binding,"Pf00443, Pf06337, Pf13423, Pf14533, Pf14836",9958,ENSG00000135655.15,USP15,12,,,UCH proteinases; Ub-specific processing proteases; Downregulation of TGF-beta receptor signaling,10,High,1
Q9H9P8,"L-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=L2HGDH PE=1 SV=3",0,232.724,56,20,519,20,463,50.3,8.15,241708,,20,,metabolic process,membrane;mitochondrion,catalytic activity,Pf01266,79944,ENSG00000087299.11,L2HGDH,14,Butanoate metabolism,,Interconversion of 2-oxoglutarate and 2-hydroxyglutarate,5,High,1
P14927,Cytochrome b-c1 complex subunit 7 OS=Homo sapiens OX=9606 GN=UQCRB PE=1 SV=2,0,232.134,69,20,1489,20,111,13.5,8.78,841263,2.07,20,4,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion,catalytic activity;protein binding;transporter activity,Pf02271,7381,ENSG00000156467.9,UQCRB,8,Cardiac muscle contraction; Parkinson's disease; Non-alcoholic fatty liver disease (NAFLD); Alzheimer's disease; Huntington's disease; Metabolic pathways; Oxidative phosphorylation,Electron Transport Chain,Respiratory electron transport,12,High,1
Q9NVE7,4'-phosphopantetheine phosphatase OS=Homo sapiens OX=9606 GN=PANK4 PE=1 SV=1,0,231.201,43,25,377,25,773,85.9,6.28,171601,12.89,24,3,metabolic process,cytoplasm,catalytic activity;nucleotide binding,"Pf01937, Pf03630",55229,ENSG00000273494.3,PANK4,1; CHR_HSCHR1_1_CTG3,Pantothenate and CoA biosynthesis; Metabolic pathways,,Coenzyme A biosynthesis,7,High,1
Q9UFN0,Protein NipSnap homolog 3A OS=Homo sapiens OX=9606 GN=NIPSNAP3A PE=1 SV=2,0,231.03,66,18,730,15,247,28.4,9.16,365295,0,18,3,,cytoplasm;cytosol;mitochondrion;nucleus,protein binding,Pf07978,25934,ENSG00000136783.9,NIPSNAP3A,9,,,,0,High,1
Q6UXV4,MICOS complex subunit MIC27 OS=Homo sapiens OX=9606 GN=APOOL PE=1 SV=1,0,230.278,66,15,790,15,268,29.1,9.52,399949,19.39,14,2,cell organization and biogenesis;transport,extracellular;membrane;mitochondrion;organelle lumen,protein binding,Pf09769,139322,ENSG00000155008.13,APOOL,X,,,Platelet degranulation ; Cristae formation,7,High,1
O75874,Isocitrate dehydrogenase [NADP] cytoplasmic OS=Homo sapiens OX=9606 GN=IDH1 PE=1 SV=2,0,230.227,54,28,1010,17,414,46.6,7.01,521775,0,28,2,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;mitochondrion;organelle lumen,catalytic activity;metal ion binding;nucleotide binding;protein binding,Pf00180,3417,ENSG00000138413.13,IDH1,2,Peroxisome; Biosynthesis of amino acids; Central carbon metabolism in cancer; 2-Oxocarboxylic acid metabolism; Carbon metabolism; Metabolic pathways; Glutathione metabolism; Citrate cycle (TCA cycle),Glutathione metabolism; TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc); Amino Acid metabolism,Neutrophil degranulation; NADPH regeneration; Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate,21,High,1
Q9Y3I0,tRNA-splicing ligase RtcB homolog OS=Homo sapiens OX=9606 GN=RTCB PE=1 SV=1,0,229.908,48,20,476,20,505,55.2,7.23,240165,1.88,20,3,metabolic process,cytoplasm;cytosol;membrane;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding,Pf01139,51493,ENSG00000100220.11,C22orf28; RTCB,22,,,tRNA processing in the nucleus,3,High,1
P51553,"Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial OS=Homo sapiens OX=9606 GN=IDH3G PE=1 SV=1",0,229.019,50,15,980,15,393,42.8,8.5,422607,76.39,13,4,metabolic process,mitochondrion;organelle lumen,catalytic activity;metal ion binding;nucleotide binding,Pf00180,3421,ENSG00000067829.18,IDH3G,X,Carbon metabolism; Metabolic pathways; Biosynthesis of amino acids; Citrate cycle (TCA cycle); 2-Oxocarboxylic acid metabolism,TCA Cycle,Mitochondrial protein import; Metabolism of proteins; Citric acid cycle (TCA cycle),12,High,1
Q01518,Adenylyl cyclase-associated protein 1 OS=Homo sapiens OX=9606 GN=CAP1 PE=1 SV=5,0,228.754,50,20,343,19,475,51.9,8.06,157614,13.46,18,3,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;extracellular;membrane;organelle lumen,protein binding,"Pf01213, Pf07986, Pf08603",10487,ENSG00000131236.16,CAP1,1,,Angiopoietin Like Protein 8 Regulatory Pathway; Insulin Signaling,Platelet degranulation ; Neutrophil degranulation; Role of ABL in ROBO-SLIT signaling,13,High,1
Q16762,Thiosulfate sulfurtransferase OS=Homo sapiens OX=9606 GN=TST PE=1 SV=4,0,228.566,69,19,740,18,297,33.4,7.25,360304,9.87,18,3,cell differentiation;metabolic process;transport,membrane;mitochondrion;organelle lumen,catalytic activity;RNA binding,Pf00581,7263,ENSG00000128311.13,TST,22,Cysteine and methionine metabolism; Sulfur metabolism; Metabolic pathways; Sulfur relay system,,Sulfide oxidation to sulfate,9,High,1
Q9UKS6,Protein kinase C and casein kinase substrate in neurons protein 3 OS=Homo sapiens OX=9606 GN=PACSIN3 PE=1 SV=2,0,228.432,52,20,441,20,424,48.5,6.18,199219,34.29,19,5,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;endosome;membrane,enzyme regulator activity;nucleotide binding;protein binding,"Pf00018, Pf00611, Pf01025, Pf07653, Pf13514, Pf14604",29763,ENSG00000165912.15,PACSIN3,11,,,Clathrin-mediated endocytosis,3,High,1
Q05682,Caldesmon OS=Homo sapiens OX=9606 GN=CALD1 PE=1 SV=3,0,228.36,32,27,508,3,793,93.2,5.66,243341,0,27,2,cellular component movement,cytoplasm;cytoskeleton;cytosol;membrane,protein binding,Pf02029,800,ENSG00000122786.19,CALD1,7,Vascular smooth muscle contraction,Myometrial Relaxation and Contraction Pathways,Smooth Muscle Contraction,4,High,1
P30740,Leukocyte elastase inhibitor OS=Homo sapiens OX=9606 GN=SERPINB1 PE=1 SV=1,0,228.314,60,21,491,20,379,42.7,6.28,225570,0,21,3,regulation of biological process;transport,cytoplasm;extracellular;membrane;organelle lumen,enzyme regulator activity,Pf00079,1992,ENSG00000021355.12,SERPINB1,6,Amoebiasis,,Neutrophil degranulation,4,High,1
Q9UDY2,Tight junction protein ZO-2 OS=Homo sapiens OX=9606 GN=TJP2 PE=1 SV=2,0,228.272,40,35,280,35,1190,133.9,7.4,120961,0,35,2,metabolic process;regulation of biological process;response to stimulus;transport,cytosol;membrane;nucleus,catalytic activity;protein binding,"Pf00595, Pf00625, Pf07653, Pf13180",9414,ENSG00000119139.17,TJP2,9,Vibrio cholerae infection; Tight junction,,Apoptotic cleavage of cell adhesion  proteins; Signaling by Hippo,9,High,1
O75155,Cullin-associated NEDD8-dissociated protein 2 OS=Homo sapiens OX=9606 GN=CAND2 PE=1 SV=3,0,228.008,29,28,365,26,1236,135.2,5.68,143324,104.08,26,13,cell organization and biogenesis;metabolic process;regulation of biological process,nucleus,protein binding,"Pf08623, Pf13513, Pf13646",23066,ENSG00000144712.11,CAND2,3,,,,0,High,1
Q15365,Poly(rC)-binding protein 1 OS=Homo sapiens OX=9606 GN=PCBP1 PE=1 SV=2,0,227.841,63,18,424,13,356,37.5,7.09,204554,44.86,15,6,metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;nucleus,DNA binding;protein binding;RNA binding,"Pf00013, Pf13014",5093,ENSG00000169564.6,PCBP1,2,Spliceosome,,mRNA Splicing - Major Pathway,5,High,1
P83111,"Serine beta-lactamase-like protein LACTB, mitochondrial OS=Homo sapiens OX=9606 GN=LACTB PE=1 SV=2",0,227.516,48,25,591,25,547,60.7,8.53,282736,16.03,25,3,metabolic process;regulation of biological process,cytosol;mitochondrion,catalytic activity;protein binding,Pf00144,114294,ENSG00000103642.11,LACTB,15,,,,0,High,1
Q99536,Synaptic vesicle membrane protein VAT-1 homolog OS=Homo sapiens OX=9606 GN=VAT1 PE=1 SV=2,0,227.507,53,20,357,20,393,41.9,6.29,164812,1.66,20,2,metabolic process;regulation of biological process;transport,cytoplasm;extracellular;membrane;mitochondrion;organelle lumen,catalytic activity;metal ion binding,"Pf00107, Pf08240, Pf13602",10493,ENSG00000108828.15,VAT1,17,,,Neutrophil degranulation,3,High,1
P02786,Transferrin receptor protein 1 OS=Homo sapiens OX=9606 GN=TFRC PE=1 SV=2,0,227.222,42,27,379,27,760,84.8,6.61,184640,0,27,2,cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;endosome;extracellular;membrane,protein binding;receptor activity;RNA binding;transporter activity,"Pf02225, Pf04253, Pf04389",7037,ENSG00000072274.12,TFRC,3,Hematopoietic cell lineage; Endocytosis; Phagosome; HIF-1 signaling pathway,Iron metabolism in placenta,Cargo recognition for clathrin-mediated endocytosis; Transferrin endocytosis and recycling; Golgi Associated Vesicle Biogenesis,15,High,1
P00441,Superoxide dismutase [Cu-Zn] OS=Homo sapiens OX=9606 GN=SOD1 PE=1 SV=2,0,227.157,82,16,477,16,154,15.9,6.13,228593,221.54,13,5,cell organization and biogenesis;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;membrane;mitochondrion;nucleus;organelle lumen;vacuole,antioxidant activity;catalytic activity;metal ion binding;protein binding,Pf00080,6647,ENSG00000142168.14,SOD1,21,Amyotrophic lateral sclerosis (ALS); Longevity regulating pathway - multiple species; Huntington's disease; Peroxisome; Prion diseases,Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism; AGE/RAGE pathway; Dopamine metabolism; Amyotrophic lateral sclerosis (ALS); Copper homeostasis; Association Between Physico-Chemical Features and Toxicity Associated Pathways; One carbon metabolism and related pathways; Oxidative Stress,Platelet degranulation ; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Interleukin-12 family signaling; Detoxification of Reactive Oxygen Species,27,High,1
Q00839,Heterogeneous nuclear ribonucleoprotein U OS=Homo sapiens OX=9606 GN=HNRNPU PE=1 SV=6,0,227.14,31,27,498,26,825,90.5,6,242649,1.81,27,3,cell differentiation;metabolic process;regulation of biological process;response to stimulus,cell surface;chromosome;cytoplasm;membrane;nucleus;spliceosomal complex,DNA binding;nucleotide binding;protein binding;RNA binding,"Pf00622, Pf13671",3192,ENSG00000153187.18,HNRNPU,1,Spliceosome,mRNA Processing,mRNA Splicing - Major Pathway,6,High,1
Q03252,Lamin-B2 OS=Homo sapiens OX=9606 GN=LMNB2 PE=1 SV=4,0,227.035,50,32,356,31,620,69.9,5.59,178234,8.61,32,6,,membrane;nucleus,catalytic activity;motor activity;protein binding;structural molecule activity,"Pf00038, Pf00932, Pf01576, Pf12128",84823,ENSG00000176619.12,LMNB2,19,Apoptosis,Gastric cancer network 2; Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation,,3,High,1
O75891,Cytosolic 10-formyltetrahydrofolate dehydrogenase OS=Homo sapiens OX=9606 GN=ALDH1L1 PE=1 SV=2,0,227.023,48,32,270,29,902,98.8,5.94,128609,11.19,30,2,metabolic process,cytoplasm;cytosol;mitochondrion,catalytic activity,"Pf00171, Pf00550, Pf00551, Pf02911",10840,ENSG00000144908.13,ALDH1L1,3,One carbon pool by folate,Folate-Alcohol and Cancer Pathway; One Carbon Metabolism,Metabolism of folate and pterines,7,High,1
Q8TB22,Spermatogenesis-associated protein 20 OS=Homo sapiens OX=9606 GN=SPATA20 PE=2 SV=3,0,226.945,39,26,416,26,786,87.8,7.43,174271,35.3,25,7,cell differentiation;development,extracellular,catalytic activity,"Pf03190, Pf13098, Pf13899",64847,ENSG00000006282.20,SPATA20,17,,,,0,High,1
P19823,Inter-alpha-trypsin inhibitor heavy chain H2 OS=Homo sapiens OX=9606 GN=ITIH2 PE=1 SV=2,0,226.9,30,21,463,21,946,106.4,6.86,225965,,21,,metabolic process;regulation of biological process,extracellular;organelle lumen,enzyme regulator activity,"Pf00092, Pf06668, Pf08487, Pf13519, Pf13768",3698,ENSG00000151655.18,ITIH2,10,,,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs),4,High,1
Q96QK1,Vacuolar protein sorting-associated protein 35 OS=Homo sapiens OX=9606 GN=VPS35 PE=1 SV=2,0,226.89,33,23,435,23,796,91.6,5.49,213049,0,23,1,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane;mitochondrion;vacuole,protein binding;transporter activity,Pf03635,55737,ENSG00000069329.16,VPS35,16,Endocytosis,,WNT ligand biogenesis and trafficking,4,High,1
P17987,T-complex protein 1 subunit alpha OS=Homo sapiens OX=9606 GN=TCP1 PE=1 SV=1,0,226.337,39,23,524,22,556,60.3,6.11,269402,4.14,23,2,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;Golgi,nucleotide binding;protein binding;RNA binding,Pf00118,6950,ENSG00000120438.11,TCP1,6,,,BBSome-mediated cargo-targeting to cilium; Prefoldin mediated transfer of substrate  to CCT/TriC; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Folding of actin by CCT/TriC; Formation of tubulin folding intermediates by CCT/TriC; Interleukin-12 family signaling,18,High,1
O94979,Protein transport protein Sec31A OS=Homo sapiens OX=9606 GN=SEC31A PE=1 SV=3,0,225.55,30,25,287,25,1220,132.9,6.89,124765,,25,,cell organization and biogenesis;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;membrane,protein binding,"Pf03154, Pf09770, Pf12931",22872,ENSG00000138674.16,SEC31A,4,Protein processing in endoplasmic reticulum,Sterol Regulatory Element-Binding Proteins (SREBP) signalling,"Antigen Presentation: Folding, assembly and peptide loading of class I MHC; COPII (Coat Protein 2) Mediated Vesicle Transport; XBP1(S) activates chaperone genes; MHC class II antigen presentation",18,High,1
P14868,"Aspartate--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=DARS PE=1 SV=2",0,225.53,63,32,393,32,501,57.1,6.55,176028,0,31,1,cell organization and biogenesis;metabolic process,cytoplasm;cytosol;membrane,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00152, Pf01336",1615,ENSG00000115866.10,DARS,2,Aminoacyl-tRNA biosynthesis,Alanine and aspartate metabolism,Cytosolic tRNA aminoacylation; SeMet incorporation into proteins,10,High,1
P26641,Elongation factor 1-gamma OS=Homo sapiens OX=9606 GN=EEF1G PE=1 SV=3,0,224.443,48,24,701,24,437,50.1,6.67,351029,0,24,2,metabolic process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus,catalytic activity;protein binding;RNA binding,"Pf00043, Pf00647, Pf02798, Pf13409, Pf13410, Pf13417, Pf14497",1937,ENSG00000254772.9,EEF1G,11,Legionellosis,Translation Factors,Eukaryotic Translation Elongation,5,High,1
Q96RL7,Vacuolar protein sorting-associated protein 13A OS=Homo sapiens OX=9606 GN=VPS13A PE=1 SV=2,0,224.404,20,41,200,41,3174,360,6.33,83354,0,40,3,metabolic process;response to stimulus;transport,cytosol,protein binding,"Pf06650, Pf12624",23230,ENSG00000197969.11,VPS13A,9,,,,0,High,1
P00488,Coagulation factor XIII A chain OS=Homo sapiens OX=9606 GN=F13A1 PE=1 SV=4,0,224.389,30,22,335,22,732,83.2,6.09,153293,0,22,1,coagulation;metabolic process;response to stimulus;transport,cytoplasm;extracellular;organelle lumen,catalytic activity;metal ion binding,"Pf00868, Pf00927, Pf01841",2162,,F13A1,6,Complement and coagulation cascades,,Platelet degranulation ; Interleukin-4 and 13 signaling; Common Pathway of Fibrin Clot Formation,11,High,1
P78344,Eukaryotic translation initiation factor 4 gamma 2 OS=Homo sapiens OX=9606 GN=EIF4G2 PE=1 SV=1,0,224.136,38,30,338,30,907,102.3,7.14,142104,14.03,29,5,cell death;metabolic process;regulation of biological process,cytosol;membrane,protein binding;RNA binding,"Pf02020, Pf02847, Pf02854",1982,ENSG00000110321.16,EIF4G2,11,RNA transport; Viral myocarditis,Exercise-induced Circadian Regulation,ISG15 antiviral mechanism,8,High,1
P30622,CAP-Gly domain-containing linker protein 1 OS=Homo sapiens OX=9606 GN=CLIP1 PE=1 SV=2,0,224.03,33,42,185,38,1438,162.1,5.36,79025,0,42,1,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;transport,chromosome;cytoplasm;cytoskeleton;cytosol;endosome;membrane,catalytic activity;metal ion binding;motor activity;protein binding,"Pf01302, Pf01576, Pf02463, Pf04111, Pf05557, Pf05622, Pf05667, Pf05701, Pf06160, Pf07111, Pf10174, Pf12128, Pf13166, Pf15254",6249,ENSG00000130779.19,CLIP1,12,mTOR signaling pathway,Regulation of Microtubule Cytoskeleton,Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; RHO GTPases activate IQGAPs,19,High,1
P17655,Calpain-2 catalytic subunit OS=Homo sapiens OX=9606 GN=CAPN2 PE=1 SV=6,0,223.876,34,21,391,21,700,79.9,4.98,179117,27.57,20,3,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;Golgi;membrane;nucleus;vacuole,catalytic activity;metal ion binding;protein binding,"Pf00648, Pf01067, Pf13833",824,ENSG00000162909.17,CAPN2,1,Apoptosis; Focal adhesion; Alzheimer's disease; Protein processing in endoplasmic reticulum,Integrin-mediated Cell Adhesion; Alzheimers Disease; VEGFA-VEGFR2 Signaling Pathway,Degradation of the extracellular matrix; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models,12,High,1
P04632,Calpain small subunit 1 OS=Homo sapiens OX=9606 GN=CAPNS1 PE=1 SV=1,0,223.546,76,15,454,15,268,28.3,5.2,213671,142.67,12,3,cell death;cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;membrane,catalytic activity;metal ion binding;protein binding,Pf13833,826,ENSG00000126247.10,CAPNS1,19,,Integrin-mediated Cell Adhesion,Degradation of the extracellular matrix; Formation of the cornified envelope; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models,9,High,1
Q15582,Transforming growth factor-beta-induced protein ig-h3 OS=Homo sapiens OX=9606 GN=TGFBI PE=1 SV=1,0,223.46,41,24,404,24,683,74.6,7.71,184967,0,24,2,cell differentiation;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,protein binding,"Pf02469, Pf07546",7045,ENSG00000120708.16,TGFBI,5,,,Amyloid fiber formation,2,High,1
Q9NVI7-2,Isoform 2 of ATPase family AAA domain-containing protein 3A OS=Homo sapiens OX=9606 GN=ATAD3A,0,223.339,51,26,421,26,586,66.2,9.25,209646,0,26,2,cell growth;regulation of biological process,membrane;mitochondrion,catalytic activity;nucleotide binding;RNA binding,"Pf00004, Pf00910, Pf01078, Pf05707, Pf06745, Pf07728, Pf12037, Pf13207, Pf13401",55210,ENSG00000197785.13,ATAD3A,1,,,,0,High,1
Q6PI48,"Aspartate--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=DARS2 PE=1 SV=1",0,223.321,39,25,345,25,645,73.5,8.02,164860,,25,,metabolic process,cytoplasm;mitochondrion;nucleus;organelle lumen,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00152, Pf00587, Pf01336, Pf02938",55157,ENSG00000117593.9,DARS2,1,Aminoacyl-tRNA biosynthesis,,Mitochondrial tRNA aminoacylation,5,High,1
P51649,"Succinate-semialdehyde dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH5A1 PE=1 SV=2",0,223.153,49,25,840,25,535,57.2,8.28,424949,17.12,24,6,cell organization and biogenesis;metabolic process,mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding,Pf00171,7915,ENSG00000112294.12,ALDH5A1,6,"Alanine, aspartate and glutamate metabolism; Butanoate metabolism; Metabolic pathways",,Degradation of GABA,8,High,1
Q9P2E9,Ribosome-binding protein 1 OS=Homo sapiens OX=9606 GN=RRBP1 PE=1 SV=5,0,222.707,29,31,157,31,1410,152.4,8.6,75854,0,31,1,,,,,,,,,,,,0,High,1
P14866,Heterogeneous nuclear ribonucleoprotein L OS=Homo sapiens OX=9606 GN=HNRNPL PE=1 SV=2,0,221.911,41,16,285,16,589,64.1,8.22,137148,0,16,1,metabolic process;regulation of biological process,cytoplasm;membrane;nucleus,DNA binding;protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",3191,ENSG00000282947.1; ENSG00000104824.16,HNRNPL,19; CHR_HG26_PATCH,,mRNA Processing,mRNA Splicing - Major Pathway,5,High,1
P10644,cAMP-dependent protein kinase type I-alpha regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR1A PE=1 SV=1,0,221.632,49,18,1038,16,381,43,5.35,502865,4.75,17,5,cell organization and biogenesis;cell proliferation;coagulation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding,"Pf00027, Pf02197",5573,ENSG00000108946.14,PRKAR1A,17,Insulin signaling pathway,miRs in Muscle Cell Differentiation; Mesodermal Commitment Pathway; Myometrial Relaxation and Contraction Pathways; G Protein Signaling Pathways; Calcium Regulation in the Cardiac Cell; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,Signaling by GPCR; PKA activation in glucagon signalling; PKA activation; DARPP-32 events; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Hedgehog 'off' state; Vasopressin regulates renal water homeostasis via Aquaporins; Factors involved in megakaryocyte development and platelet production,33,High,1
Q16798,"NADP-dependent malic enzyme, mitochondrial OS=Homo sapiens OX=9606 GN=ME3 PE=2 SV=2",0,220.965,46,22,458,21,604,67,7.97,199196,92.14,19,6,metabolic process,mitochondrion;organelle lumen,catalytic activity;metal ion binding;nucleotide binding,"Pf00390, Pf03949",10873,ENSG00000151376.16,ME3,11,Metabolic pathways; Carbon metabolism; Pyruvate metabolism,,,3,High,1
P29692,Elongation factor 1-delta OS=Homo sapiens OX=9606 GN=EEF1D PE=1 SV=5,0,220.862,55,16,641,15,281,31.1,5.01,347948,7.96,15,1,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;nucleus,DNA binding;protein binding;RNA binding;signal transducer activity,"Pf00736, Pf10587",1936,ENSG00000104529.17; ENSG00000273594.4,EEF1D,8; CHR_HSCHR8_3_CTG7,Herpes simplex infection,Translation Factors,Eukaryotic Translation Elongation,5,High,1
Q13409-2,Isoform 2B of Cytoplasmic dynein 1 intermediate chain 2 OS=Homo sapiens OX=9606 GN=DYNC1I2,0,220.709,42,21,171,19,632,70.6,5.24,73690,53.61,20,1,cell organization and biogenesis;cellular component movement;regulation of biological process;transport,cytoplasm;cytosol,catalytic activity;motor activity;protein binding,"Pf00400, Pf11540",1781,ENSG00000077380.15,DYNC1I2,2,,,,0,High,1
P51888,Prolargin OS=Homo sapiens OX=9606 GN=PRELP PE=1 SV=1,0,220.624,40,21,1416,21,382,43.8,9.38,671293,0,21,3,cell organization and biogenesis;metabolic process,extracellular;organelle lumen,protein binding;structural molecule activity,"Pf01462, Pf12799, Pf13855",5549,ENSG00000188783.5,PRELP,1,,,Keratan sulfate biosynthesis; Defective CHST6 causes MCDC1; Defective ST3GAL3 causes MCT12 and EIEE15; Defective B4GALT1 causes B4GALT1-CDG (CDG-2d); Keratan sulfate degradation,12,High,1
Q7Z460,CLIP-associating protein 1 OS=Homo sapiens OX=9606 GN=CLASP1 PE=1 SV=1,0,220.583,28,38,257,34,1538,169.3,9.03,113724,,38,,cell division;cell organization and biogenesis;regulation of biological process,chromosome;cytoplasm;cytoskeleton;cytosol;Golgi;membrane,protein binding,"Pf02985, Pf12348",23332,ENSG00000074054.17,CLASP1,2,,Regulation of Microtubule Cytoskeleton,Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; Role of ABL in ROBO-SLIT signaling,33,High,1
O00763,Acetyl-CoA carboxylase 2 OS=Homo sapiens OX=9606 GN=ACACB PE=1 SV=3,0,220.481,21,40,160,32,2458,276.4,6.49,67215,16.38,39,4,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;membrane;mitochondrion;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00289, Pf00364, Pf01039, Pf02785, Pf02786, Pf08326, Pf13535, Pf15449, Pf15632",32,ENSG00000076555.15,ACACB,12,Adipocytokine signaling pathway; Glucagon signaling pathway; Metabolic pathways; Pyruvate metabolism; Propanoate metabolism; Insulin resistance; AMPK signaling pathway; Fatty acid biosynthesis; Insulin signaling pathway,AMP-activated Protein Kinase (AMPK) Signaling; Leptin signaling pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Fatty Acid Biosynthesis; VEGFA-VEGFR2 Signaling Pathway,ChREBP activates metabolic gene expression; Import of palmitoyl-CoA into the mitochondrial matrix; Biotin transport and metabolism; Activation of gene expression by SREBF (SREBP),26,High,1
P54136,"Arginine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=RARS PE=1 SV=2",0,220.172,42,28,336,28,660,75.3,6.68,153022,0,28,3,metabolic process,cytoplasm;cytosol;membrane;mitochondrion;nucleus,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00750, Pf03485, Pf05746",5917,ENSG00000113643.8,RARS,5,Aminoacyl-tRNA biosynthesis,Amino Acid metabolism,Cytosolic tRNA aminoacylation; SeMet incorporation into proteins,10,High,1
P39060,Collagen alpha-1(XVIII) chain OS=Homo sapiens OX=9606 GN=COL18A1 PE=1 SV=5,0,220.127,16,22,493,22,1754,178.1,6.01,238133,0,22,3,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,extracellular;organelle lumen,metal ion binding;protein binding;structural molecule activity,"Pf01391, Pf01392, Pf06121, Pf06482, Pf13385",80781,ENSG00000182871.14,COL18A1,21,Protein digestion and absorption,,Collagen degradation; Activation of Matrix Metalloproteinases; Integrin cell surface interactions; Laminin interactions; Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization,11,High,1
Q9UJS0,Calcium-binding mitochondrial carrier protein Aralar2 OS=Homo sapiens OX=9606 GN=SLC25A13 PE=1 SV=2,0,220.033,55,32,626,22,675,74.1,8.62,314990,4.63,31,2,metabolic process;response to stimulus;transport,membrane;mitochondrion,metal ion binding;transporter activity,"Pf00153, Pf13499",10165,ENSG00000004864.13,SLC25A13,7,,,Gluconeogenesis; Mitochondrial protein import; Metabolism of proteins,6,High,1
P06727,Apolipoprotein A-IV OS=Homo sapiens OX=9606 GN=APOA4 PE=1 SV=3,0,219.573,59,25,339,25,396,45.4,5.38,160176,0,25,3,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytosol;endosome;extracellular;organelle lumen,antioxidant activity;catalytic activity;enzyme regulator activity;metal ion binding;protein binding;transporter activity,"Pf01442, Pf06386, Pf07902",337,,APOA4,11,,Statin Pathway,Signaling by GPCR; Assembly of active LPL and LIPC lipase complexes; Amyloid fiber formation; Retinoid metabolism and transport; Chylomicron assembly; Chylomicron remodeling,17,High,1
P22392-2,Isoform 3 of Nucleoside diphosphate kinase B OS=Homo sapiens OX=9606 GN=NME2,0,219.448,61,16,999,7,267,30.1,8.92,512140,0,16,2,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen,catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding,Pf00334,654364; 4830; 4831,ENSG00000011052.21,NME1-NME2; NME1; NME2,17,Purine metabolism; Metabolic pathways; Pyrimidine metabolism,Nucleotide Metabolism,,4,High,1
P08603,Complement factor H OS=Homo sapiens OX=9606 GN=CFH PE=1 SV=4,0,219.424,22,24,435,23,1231,139,6.61,196598,38.48,18,9,defense response;metabolic process;regulation of biological process;response to stimulus,extracellular,protein binding,Pf00084,3075,,CFH,1,Complement and coagulation cascades; Staphylococcus aureus infection,Complement and Coagulation Cascades,Regulation of Complement cascade,7,High,1
Q9Y696,Chloride intracellular channel protein 4 OS=Homo sapiens OX=9606 GN=CLIC4 PE=1 SV=4,0,218.82,60,19,540,17,253,28.8,5.59,256176,26.92,17,3,cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus,catalytic activity;protein binding;transporter activity,"Pf00043, Pf13409, Pf13410, Pf13417, Pf14497",25932,ENSG00000169504.14,CLIC4,1,,,,0,High,1
O60271,C-Jun-amino-terminal kinase-interacting protein 4 OS=Homo sapiens OX=9606 GN=SPAG9 PE=1 SV=4,0,218.651,39,36,178,31,1321,146.1,5.15,78838,0,36,1,cell differentiation;cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytosol,protein binding;structural molecule activity,Pf09744,9043,ENSG00000008294.20,SPAG9,17,,,CDO in myogenesis,3,High,1
Q9UJZ1,"Stomatin-like protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=STOML2 PE=1 SV=1",0,218.566,62,16,390,16,356,38.5,7.39,189837,5.11,16,1,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;membrane;mitochondrion,protein binding,Pf01145,30968,ENSG00000165283.15,STOML2,9,,,Processing of SMDT1,3,High,1
Q9NVH1,DnaJ homolog subfamily C member 11 OS=Homo sapiens OX=9606 GN=DNAJC11 PE=1 SV=2,0,218.375,40,21,498,21,559,63.2,8.4,232491,0,21,1,cell organization and biogenesis,membrane;mitochondrion,protein binding,"Pf00226, Pf11875",55735,ENSG00000007923.15,DNAJC11,1,,,Cristae formation,3,High,1
O43242,26S proteasome non-ATPase regulatory subunit 3 OS=Homo sapiens OX=9606 GN=PSMD3 PE=1 SV=2,0,217.78,49,25,457,25,534,60.9,8.44,215579,,25,,metabolic process;regulation of biological process;response to stimulus;transport,cytosol;extracellular;membrane;nucleus;organelle lumen;proteasome,catalytic activity;enzyme regulator activity;protein binding,"Pf01399, Pf08375",5709,ENSG00000108344.14,PSMD3,17,Epstein-Barr virus infection; Proteasome,Proteasome Degradation; Parkin-Ubiquitin Proteasomal System pathway,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Neutrophil degranulation; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,153,High,1
Q13418,Integrin-linked protein kinase OS=Homo sapiens OX=9606 GN=ILK PE=1 SV=2,0,217.058,41,21,711,21,452,51.4,8.07,334344,10.04,19,3,cell organization and biogenesis;cell proliferation;cellular component movement;development;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;nucleotide binding;protein binding;signal transducer activity,"Pf00023, Pf00069, Pf07714, Pf12796, Pf13606, Pf13637, Pf13857",3611,ENSG00000166333.13,ILK,11,Bacterial invasion of epithelial cells; PPAR signaling pathway; Focal adhesion; Axon guidance; Endometrial cancer,Integrin-mediated Cell Adhesion; Primary Focal Segmental Glomerulosclerosis FSGS; Focal Adhesion; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; PPAR signaling pathway; Eukaryotic Transcription Initiation,Localization of the PINCH-ILK-PARVIN complex to focal adhesions,15,High,1
P13797,Plastin-3 OS=Homo sapiens OX=9606 GN=PLS3 PE=1 SV=4,0,217.021,45,29,324,26,630,70.8,5.6,162870,2.8,28,2,cell organization and biogenesis,cytoplasm;cytosol;membrane,metal ion binding;protein binding,"Pf00036, Pf00307, Pf13499",5358,ENSG00000102024.17,PLS3,X,,,,0,High,1
Q13310,Polyadenylate-binding protein 4 OS=Homo sapiens OX=9606 GN=PABPC4 PE=1 SV=1,0,216.989,37,26,492,18,644,70.7,9.26,222991,2.96,26,4,coagulation;metabolic process,cytoplasm;cytosol;nucleus,protein binding;RNA binding,"Pf00076, Pf00658, Pf13893, Pf14259",8761,ENSG00000090621.13,PABPC4,1,mRNA surveillance pathway; RNA transport; RNA degradation,,,3,High,1
Q05682-3,Isoform 3 of Caldesmon OS=Homo sapiens OX=9606 GN=CALD1,0,216.291,43,25,382,1,558,64.2,7.02,183034,7.29,24,3,cellular component movement,cytoskeleton;cytosol;membrane,protein binding,Pf02029,800,ENSG00000122786.19,CALD1,7,,Myometrial Relaxation and Contraction Pathways,,1,High,1
Q99832,T-complex protein 1 subunit eta OS=Homo sapiens OX=9606 GN=CCT7 PE=1 SV=2,0,216.259,44,23,597,23,543,59.3,7.65,272881,0,23,2,metabolic process;regulation of biological process;transport,cytoplasm;cytosol;mitochondrion,nucleotide binding;protein binding,Pf00118,10574,ENSG00000135624.15,CCT7,2,,,Prefoldin mediated transfer of substrate  to CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Formation of tubulin folding intermediates by CCT/TriC; Folding of actin by CCT/TriC,9,High,1
Q15029,116 kDa U5 small nuclear ribonucleoprotein component OS=Homo sapiens OX=9606 GN=EFTUD2 PE=1 SV=1,0,216.116,42,32,358,31,972,109.4,5,153715,0,31,2,cell organization and biogenesis;metabolic process;response to stimulus,cytosol;membrane;nucleus;spliceosomal complex,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00009, Pf00679, Pf03144, Pf03764, Pf14492",9343,ENSG00000108883.12,EFTUD2,17,Spliceosome,mRNA Processing,mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway,7,High,1
P55060,Exportin-2 OS=Homo sapiens OX=9606 GN=CSE1L PE=1 SV=3,0,215.913,31,28,402,28,971,110.3,5.77,166225,0,28,1,cell death;cell proliferation;transport,cytoplasm;cytosol;membrane;nucleus,protein binding;transporter activity,"Pf03378, Pf03810, Pf08506",1434,ENSG00000124207.16,CSE1L,20,,,,0,High,1
P13716,Delta-aminolevulinic acid dehydratase OS=Homo sapiens OX=9606 GN=ALAD PE=1 SV=1,0,215.731,47,17,357,17,330,36.3,6.79,172335,1.66,17,2,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;extracellular;nucleus;organelle lumen,catalytic activity;metal ion binding;protein binding,Pf00490,210,ENSG00000148218.15,ALAD,9,Metabolic pathways; Porphyrin and chlorophyll metabolism,Heme Biosynthesis,Heme biosynthesis; Neutrophil degranulation,9,High,1
Q8NBF2,NHL repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=NHLRC2 PE=1 SV=1,0,215.282,43,24,381,24,726,79.4,5.55,175921,4.78,22,4,cellular homeostasis;metabolic process;regulation of biological process;transport,extracellular;organelle lumen,antioxidant activity;catalytic activity;protein binding,"Pf00578, Pf01436, Pf13905",374354,ENSG00000196865.4,NHLRC2,10,,,Platelet degranulation,4,High,1
P43034,Platelet-activating factor acetylhydrolase IB subunit alpha OS=Homo sapiens OX=9606 GN=PAFAH1B1 PE=1 SV=2,0,214.794,49,19,437,19,410,46.6,7.37,192281,6.07,18,3,cell communication;cell differentiation;cell division;cell organization and biogenesis;cell proliferation;cellular component movement;development;metabolic process;regulation of biological process;response to stimulus;transport,chromosome;cytoplasm;cytoskeleton;cytosol;membrane;nucleus,catalytic activity;protein binding,"Pf00400, Pf08513, Pf11715",5048,ENSG00000007168.12,PAFAH1B1,17,Metabolic pathways; Ether lipid metabolism,Wnt Signaling Pathway and Pluripotency; Wnt Signaling Pathway,COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins,37,High,1
Q9UMX0,Ubiquilin-1 OS=Homo sapiens OX=9606 GN=UBQLN1 PE=1 SV=2,0,214.701,41,15,189,1,589,62.5,5.11,93238,0,15,1,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;proteasome;vacuole,protein binding,"Pf00240, Pf00627, Pf11976",29979,ENSG00000135018.13,UBQLN1,9,Protein processing in endoplasmic reticulum,,Cargo recognition for clathrin-mediated endocytosis,5,High,1
O75165,DnaJ homolog subfamily C member 13 OS=Homo sapiens OX=9606 GN=DNAJC13 PE=1 SV=5,0,214.548,23,39,171,39,2243,254.3,6.74,72490,0,38,1,cell differentiation;cell organization and biogenesis;regulation of biological process;transport,cytosol;endosome;membrane,protein binding,"Pf00226, Pf14237",23317,ENSG00000138246.15,DNAJC13,3,,,Neutrophil degranulation,3,High,1
Q6P5Q4,Leiomodin-2 OS=Homo sapiens OX=9606 GN=LMOD2 PE=1 SV=2,0,214.338,48,20,282,20,547,61.6,5.78,82915,337.73,11,14,cell organization and biogenesis;regulation of biological process,cytoplasm;cytoskeleton,protein binding,Pf03250,442721,ENSG00000170807.11,LMOD2,7,,,,0,High,1
Q9BXW7,Haloacid dehalogenase-like hydrolase domain-containing 5 OS=Homo sapiens OX=9606 GN=HDHD5 PE=1 SV=1,0,213.773,41,16,374,16,423,46.3,8.13,184808,4.61,16,3,metabolic process,mitochondrion,,Pf13344,27440,ENSG00000069998.12,CECR5; HDHD5,22,,,,0,High,1
Q8N335,Glycerol-3-phosphate dehydrogenase 1-like protein OS=Homo sapiens OX=9606 GN=GPD1L PE=1 SV=1,0,213.695,54,19,1554,18,351,38.4,7.02,713613,48.36,16,5,metabolic process;regulation of biological process,cytoplasm;cytosol;membrane,catalytic activity;nucleotide binding;protein binding,"Pf01210, Pf07479",23171,ENSG00000152642.10,GPD1L,3,Glycerophospholipid metabolism,Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,Synthesis of PA,7,High,1
P41250,Glycine--tRNA ligase OS=Homo sapiens OX=9606 GN=GARS1 PE=1 SV=3,0,213.176,39,24,366,24,739,83.1,7.03,162097,0,24,3,metabolic process,cytoplasm;cytosol;extracellular;mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding,"Pf00458, Pf00587, Pf03129",2617,ENSG00000106105.13,GARS,7,Aminoacyl-tRNA biosynthesis,,Mitochondrial tRNA aminoacylation; Cytosolic tRNA aminoacylation,6,High,1
Q9HBL0-2,Isoform 2 of Tensin-1 OS=Homo sapiens OX=9606 GN=TNS1,0,212.59,54,18,373,1,416,47.2,6.98,157889,32.5,16,3,cell organization and biogenesis;cellular component movement,cell surface;cytoplasm;cytoskeleton,protein binding;RNA binding,Pf10409,7145,ENSG00000079308.16,TNS1,2,,Integrin-mediated Cell Adhesion,,1,High,1
O15327,Inositol polyphosphate 4-phosphatase type II OS=Homo sapiens OX=9606 GN=INPP4B PE=1 SV=4,0,212.019,40,28,264,28,924,104.7,6.27,117353,2.68,28,2,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,catalytic activity;protein binding,,8821,ENSG00000109452.12,INPP4B,4,Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system,VEGFA-VEGFR2 Signaling Pathway,"Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of IP2, IP, and Ins in the cytosol",12,High,1
Q9NY33,Dipeptidyl peptidase 3 OS=Homo sapiens OX=9606 GN=DPP3 PE=1 SV=2,0,211.428,47,24,207,24,737,82.5,5.1,94689,,24,,metabolic process,cytoplasm;cytosol;membrane,catalytic activity;metal ion binding;protein binding,Pf03571,10072,ENSG00000254986.7,DPP3,11,,,,0,High,1
Q8IUG5,Unconventional myosin-XVIIIb OS=Homo sapiens OX=9606 GN=MYO18B PE=1 SV=2,0,211.355,19,37,235,35,2567,285,6.86,60307,232.52,8,29,,,,,,,,,,,,0,High,1
P13591,Neural cell adhesion molecule 1 OS=Homo sapiens OX=9606 GN=NCAM1 PE=1 SV=3,0,211.304,28,26,333,26,858,94.5,4.87,154180,3.56,25,2,cellular component movement;metabolic process;regulation of biological process;response to stimulus,cell surface;cytosol;extracellular;membrane,protein binding;receptor activity,"Pf00041, Pf00047, Pf07654, Pf07679, Pf08205, Pf13895, Pf13927",4684,ENSG00000149294.16,NCAM1,11,Prion diseases; Cell adhesion molecules (CAMs),Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Cardiac Progenitor Differentiation,ECM proteoglycans; Signal transduction by L1; Interferon gamma signaling; NCAM1 interactions; RAF/MAP kinase cascade; Interleukin-20 family signaling,22,High,1
P42025,Beta-centractin OS=Homo sapiens OX=9606 GN=ACTR1B PE=1 SV=1,0,211.047,55,16,370,7,376,42.3,6.4,180798,4.39,16,3,transport,cytoplasm;cytoskeleton;cytosol;extracellular;membrane;organelle lumen,nucleotide binding;protein binding,Pf00022,10120,ENSG00000115073.7,ACTR1B,2,,,Neutrophil degranulation; MHC class II antigen presentation,5,High,1
P02766,Transthyretin OS=Homo sapiens OX=9606 GN=TTR PE=1 SV=1,0,210.844,65,15,540,15,147,15.9,5.76,263725,2.35,15,1,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;extracellular;organelle lumen,protein binding,Pf00576,7276,ENSG00000118271.9,TTR,18,Thyroid hormone synthesis,,Signaling by GPCR; Neutrophil degranulation; The canonical retinoid cycle in rods (twilight vision); Amyloid fiber formation; Retinoid metabolism and transport; Retinoid cycle disease events; Non-integrin membrane-ECM interactions,20,High,1
P21810,Biglycan OS=Homo sapiens OX=9606 GN=BGN PE=1 SV=2,0,210.821,37,19,759,19,368,41.6,7.52,393153,0,19,2,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cell surface;cytoplasm;extracellular;membrane;organelle lumen,enzyme regulator activity;protein binding;structural molecule activity,"Pf01462, Pf12799, Pf13855, Pf14580",633,ENSG00000182492.15,BGN,X,,,"ECM proteoglycans; A tetrasaccharide linker sequence is required for GAG synthesis; Dermatan sulfate biosynthesis; Defective CHSY1 causes TPBS; Defective B4GALT7 causes EDS, progeroid type; Defective B3GALT6 causes EDSP2 and SEMDJL1; CS/DS degradation; Defective CHST14 causes EDS, musculocontractural type; Defective CHST3 causes SEDCJD; Chondroitin sulfate biosynthesis; Defective B3GAT3 causes JDSSDHD",20,High,1
P19404,"NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFV2 PE=1 SV=2",0,210.767,58,21,1280,21,249,27.4,8.06,646381,57.39,17,7,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion,catalytic activity;metal ion binding;protein binding,Pf01257,4729,ENSG00000178127.12,NDUFV2,18,Huntington's disease; Oxidative phosphorylation; Metabolic pathways; Parkinson's disease; Non-alcoholic fatty liver disease (NAFLD); Alzheimer's disease,Electron Transport Chain; Oxidative phosphorylation,Complex I biogenesis,13,High,1
P62191,26S proteasome regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PSMC1 PE=1 SV=1,0,210.712,57,23,348,21,440,49.2,6.21,167923,8.12,21,2,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus;proteasome,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00004, Pf00910, Pf01078, Pf05496, Pf05673, Pf05729, Pf07724, Pf07726, Pf07728, Pf13191, Pf13401",5700,ENSG00000100764.13,PSMC1,14,Viral carcinogenesis; Proteasome; Epstein-Barr virus infection,Proteasome Degradation; Parkin-Ubiquitin Proteasomal System pathway,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,155,High,1
Q63ZY3,KN motif and ankyrin repeat domain-containing protein 2 OS=Homo sapiens OX=9606 GN=KANK2 PE=1 SV=1,0,210.582,41,24,292,22,851,91.1,5.63,130263,15.26,23,3,cell death;metabolic process;regulation of biological process,cytoplasm;mitochondrion,protein binding,"Pf00023, Pf12075, Pf12796, Pf13606, Pf13637, Pf13857",25959,ENSG00000197256.10,KANK2,19,,,,0,High,1
P49792,E3 SUMO-protein ligase RanBP2 OS=Homo sapiens OX=9606 GN=RANBP2 PE=1 SV=2,0,210.513,17,38,191,24,3224,358,6.2,83008,,38,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;mitochondrion;nucleus,catalytic activity;enzyme regulator activity;metal ion binding;protein binding;RNA binding,"Pf00160, Pf00515, Pf00638, Pf00641, Pf07719, Pf12185, Pf13414, Pf13432, Pf14559",5903,ENSG00000153201.15,RANBP2,2,RNA transport,,Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; Separation of Sister Chromatids; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Resolution of Sister Chromatid Cohesion; Transport of Ribonucleoproteins into the Host Nucleus; RHO GTPases Activate Formins; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins,77,High,1
P49189-3,Isoform 3 of 4-trimethylaminobutyraldehyde dehydrogenase OS=Homo sapiens OX=9606 GN=ALDH9A1,0,210.25,53,27,665,24,518,56.3,6.57,330021,50.45,21,10,,,,,,,,,,,,0,High,1
Q9Y6C9,Mitochondrial carrier homolog 2 OS=Homo sapiens OX=9606 GN=MTCH2 PE=1 SV=1,0,210.234,49,18,653,18,303,33.3,7.97,319269,29.86,16,3,regulation of biological process;transport,membrane;mitochondrion;nucleus,,Pf00153,23788,ENSG00000109919.9,MTCH2,11,,,,0,High,1
Q00341,Vigilin OS=Homo sapiens OX=9606 GN=HDLBP PE=1 SV=2,0,209.815,36,35,221,35,1268,141.4,6.87,94392,0,35,3,metabolic process;transport,cytoplasm;cytosol;membrane;nucleus,protein binding;RNA binding,"Pf00013, Pf13014, Pf14611",3069,,HDLBP,2,,,HDL clearance,4,High,1
Q9UNZ2,NSFL1 cofactor p47 OS=Homo sapiens OX=9606 GN=NSFL1C PE=1 SV=2,0,209.787,62,19,303,19,370,40.5,5.1,137331,,19,,cell organization and biogenesis;metabolic process;regulation of biological process,chromosome;cytoskeleton;cytosol;Golgi;membrane;nucleus,enzyme regulator activity;protein binding,"Pf00789, Pf08059, Pf14555",55968,ENSG00000088833.17,NSFL1C,20,Protein processing in endoplasmic reticulum,,,1,High,1
P23229,Integrin alpha-6 OS=Homo sapiens OX=9606 GN=ITGA6 PE=1 SV=5,0,209.326,37,32,283,32,1130,126.5,6.61,119739,0,32,1,cell communication;cell differentiation;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cell surface;membrane,metal ion binding;protein binding,"Pf01839, Pf08441, Pf13517",3655,ENSG00000091409.14,ITGA6,2,PI3K-Akt signaling pathway; Dilated cardiomyopathy; Focal adhesion; Hypertrophic cardiomyopathy (HCM); Hematopoietic cell lineage; Regulation of actin cytoskeleton; Cell adhesion molecules (CAMs); Small cell lung cancer; Pathways in cancer; ECM-receptor interaction; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Toxoplasmosis,Integrin-mediated Cell Adhesion; Arrhythmogenic Right Ventricular Cardiomyopathy; Alpha 6 Beta 4 signaling pathway; Focal Adhesion; Regulation of Apoptosis by Parathyroid Hormone-related Protein; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,Integrin cell surface interactions; Laminin interactions; Basigin interactions; Assembly of collagen fibrils and other multimeric structures; Type I hemidesmosome assembly; Syndecan interactions,31,High,1
Q10713,Mitochondrial-processing peptidase subunit alpha OS=Homo sapiens OX=9606 GN=PMPCA PE=1 SV=2,0,209.153,49,20,405,20,525,58.2,6.92,201440,2.7,20,1,metabolic process;transport,membrane;mitochondrion;organelle lumen,catalytic activity;metal ion binding,"Pf00675, Pf05193",23203,ENSG00000165688.11,PMPCA,9,,,Processing of SMDT1; Mitochondrial protein import; Metabolism of proteins,5,High,1
P38606,V-type proton ATPase catalytic subunit A OS=Homo sapiens OX=9606 GN=ATP6V1A PE=1 SV=2,0,209.149,51,25,358,25,617,68.3,5.52,166946,0,25,1,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;membrane;mitochondrion,catalytic activity;nucleotide binding;transporter activity,"Pf00006, Pf00306, Pf02874",523,ENSG00000114573.9,ATP6V1A,3,Oxidative phosphorylation; Metabolic pathways; Phagosome; Synaptic vesicle cycle; Epithelial cell signaling in Helicobacter pylori infection; Vibrio cholerae infection; mTOR signaling pathway; Rheumatoid arthritis; Collecting duct acid secretion,,"Transferrin endocytosis and recycling; ROS, RNS production in phagocytes; Ion channel transport; Insulin receptor recycling",20,High,1
Q9NX40,OCIA domain-containing protein 1 OS=Homo sapiens OX=9606 GN=OCIAD1 PE=1 SV=1,0,208.865,60,18,412,18,245,27.6,7.49,199175,,18,,regulation of biological process,endosome;membrane;mitochondrion,protein binding,Pf07051,54940,ENSG00000109180.14,OCIAD1,4,,,,0,High,1
Q969Z0,FAST kinase domain-containing protein 4 OS=Homo sapiens OX=9606 GN=TBRG4 PE=1 SV=1,0,208.339,42,21,302,21,631,70.7,7.42,138348,,21,,metabolic process;regulation of biological process,mitochondrion,catalytic activity;protein binding;RNA binding,"Pf06743, Pf08368, Pf08373",9238,ENSG00000136270.13,TBRG4,7,,,,0,High,1
P13861,cAMP-dependent protein kinase type II-alpha regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR2A PE=1 SV=2,0,208.334,58,19,507,16,404,45.5,5.07,242179,0,19,1,coagulation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding,"Pf00027, Pf02197",5576,ENSG00000114302.15,PRKAR2A,3,Insulin signaling pathway,miRs in Muscle Cell Differentiation; Myometrial Relaxation and Contraction Pathways; G Protein Signaling Pathways; TGF-beta Signaling Pathway; Calcium Regulation in the Cardiac Cell; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,DARPP-32 events; ROBO receptors bind AKAP5; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Hedgehog 'off' state; Vasopressin regulates renal water homeostasis via Aquaporins; Factors involved in megakaryocyte development and platelet production; Signaling by GPCR; PKA activation in glucagon signalling; PKA activation,37,High,1
Q96EY7,"Pentatricopeptide repeat domain-containing protein 3, mitochondrial OS=Homo sapiens OX=9606 GN=PTCD3 PE=1 SV=3",0,208.283,39,22,349,22,689,78.5,6.42,171124,0,22,1,cell organization and biogenesis;metabolic process;regulation of biological process,cytosol;membrane;mitochondrion;ribosome,protein binding;RNA binding,"Pf13041, Pf13812",55037,ENSG00000132300.18,PTCD3,2,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
Q6ZVM7,TOM1-like protein 2 OS=Homo sapiens OX=9606 GN=TOM1L2 PE=1 SV=1,0,208.006,52,22,219,2,507,55.5,4.79,104263,3.54,22,1,regulation of biological process;response to stimulus;transport,,protein binding,"Pf00790, Pf01417, Pf03127",146691,ENSG00000175662.17,TOM1L2,17,,,,0,High,1
Q13045,Protein flightless-1 homolog OS=Homo sapiens OX=9606 GN=FLII PE=1 SV=2,0,207.988,27,29,276,4,1269,144.7,6.05,127071,0,29,2,cell organization and biogenesis;development;metabolic process;regulation of biological process,cytoplasm;cytoskeleton;cytosol;nucleus,protein binding,"Pf00626, Pf12799, Pf13855",2314,ENSG00000177731.15; ENSG00000284571.1,FLII,17; CHR_HSCHR17_3_CTG1,,,,0,High,1
O43772,Mitochondrial carnitine/acylcarnitine carrier protein OS=Homo sapiens OX=9606 GN=SLC25A20 PE=1 SV=1,0,207.967,67,23,962,23,301,32.9,9.41,486939,11.69,21,6,transport,cytosol;membrane;mitochondrion,transporter activity,Pf00153,788,ENSG00000178537.9,SLC25A20,3,,Fatty Acid Beta Oxidation; Mitochondrial LC-Fatty Acid Beta-Oxidation,Import of palmitoyl-CoA into the mitochondrial matrix,6,High,1
Q02878,60S ribosomal protein L6 OS=Homo sapiens OX=9606 GN=RPL6 PE=1 SV=3,0,207.107,49,24,734,24,288,32.7,10.58,378363,2.01,24,2,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytosol;membrane;nucleus;ribosome,DNA binding;protein binding;RNA binding;structural molecule activity,"Pf01159, Pf03868",6128,ENSG00000089009.15,RPL6,12,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
Q9UN36,Protein NDRG2 OS=Homo sapiens OX=9606 GN=NDRG2 PE=1 SV=2,0,207.067,52,16,342,16,371,40.8,5.21,150048,0,16,2,cell differentiation;development;regulation of biological process;response to stimulus,cytoplasm;cytosol;Golgi;nucleus,protein binding,"Pf00561, Pf03096, Pf12697",57447,ENSG00000165795.23,NDRG2,14,,,,0,High,1
Q9UMX0-2,Isoform 2 of Ubiquilin-1 OS=Homo sapiens OX=9606 GN=UBQLN1,0,207.024,44,15,188,1,561,59.2,5.1,91847,3.94,14,2,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;membrane;proteasome;vacuole,protein binding,"Pf00240, Pf00627, Pf11976",29979,ENSG00000135018.13,UBQLN1,9,,,,0,High,1
Q9NZ08,Endoplasmic reticulum aminopeptidase 1 OS=Homo sapiens OX=9606 GN=ERAP1 PE=1 SV=3,0,207.015,38,31,265,31,941,107.2,6.46,114129,0,31,1,cell communication;cell differentiation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;extracellular;membrane;organelle lumen,catalytic activity;metal ion binding;protein binding,"Pf01433, Pf11838, Pf13485",51752,ENSG00000164307.12,ERAP1,5,,,"Antigen Presentation: Folding, assembly and peptide loading of class I MHC",4,High,1
Q53GG5,PDZ and LIM domain protein 3 OS=Homo sapiens OX=9606 GN=PDLIM3 PE=1 SV=1,0,206.887,48,15,547,3,364,39.2,6.89,265033,20.55,13,4,cell organization and biogenesis,cytoplasm;cytoskeleton;cytosol,metal ion binding;protein binding;structural molecule activity,"Pf00412, Pf00595, Pf13180",27295,ENSG00000154553.13,PDLIM3,4,,,,0,High,1
Q9H4A4,Aminopeptidase B OS=Homo sapiens OX=9606 GN=RNPEP PE=1 SV=2,0,206.488,42,26,285,26,650,72.5,5.74,130127,0,26,1,metabolic process,extracellular;membrane,catalytic activity;metal ion binding,"Pf01433, Pf09127, Pf13485",6051,ENSG00000176393.10,RNPEP,1,,,,0,High,1
O60825,"6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 OS=Homo sapiens OX=9606 GN=PFKFB2 PE=1 SV=2",0,206.202,55,26,405,1,505,58.4,8.38,188040,,26,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,catalytic activity;nucleotide binding;protein binding,"Pf00300, Pf01591, Pf13207, Pf13671",5208,ENSG00000123836.14,PFKFB2,1,AMPK signaling pathway; Thyroid hormone signaling pathway; Fructose and mannose metabolism,Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,Glycolysis,8,High,1
P55884,Eukaryotic translation initiation factor 3 subunit B OS=Homo sapiens OX=9606 GN=EIF3B PE=1 SV=3,0,205.8,41,29,216,29,814,92.4,5,94691,,29,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol,protein binding;RNA binding;structural molecule activity,"Pf00076, Pf08662, Pf13893, Pf14259",8662,ENSG00000106263.17,EIF3B,7,RNA transport,Translation Factors,"Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Ribosomal scanning and start codon recognition",13,High,1
P46459,Vesicle-fusing ATPase OS=Homo sapiens OX=9606 GN=NSF PE=1 SV=3,0,205.569,43,32,271,31,744,82.5,6.95,123133,,32,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding,"Pf00004, Pf00910, Pf01078, Pf02359, Pf02933, Pf05272, Pf05496, Pf06068, Pf07724, Pf07728, Pf13173, Pf13191, Pf13207, Pf13401",4905,ENSG00000073969.18; ENSG00000278174.3; ENSG00000276262.2,NSF,17; CHR_HSCHR17_1_CTG5; CHR_HSCHR17_2_CTG5,Vasopressin-regulated water reabsorption; GABAergic synapse; Synaptic vesicle cycle,Synaptic Vesicle Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway,COPI-dependent Golgi-to-ER retrograde traffic; Intra-Golgi traffic; COPII (Coat Protein 2) Mediated Vesicle Transport; COPI-mediated anterograde transport; Retrograde transport at the Trans-Golgi-Network; Trafficking of GluR2-containing AMPA receptors,25,High,1
Q9Y285,Phenylalanine--tRNA ligase alpha subunit OS=Homo sapiens OX=9606 GN=FARSA PE=1 SV=3,0,205.375,52,25,299,25,508,57.5,7.8,124716,0,25,1,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;membrane,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00152, Pf01409, Pf08279, Pf12802, Pf13463",2193,ENSG00000179115.10,FARSA,19,Aminoacyl-tRNA biosynthesis,,Cytosolic tRNA aminoacylation,5,High,1
Q5JPE7,Nodal modulator 2 OS=Homo sapiens OX=9606 GN=NOMO2 PE=1 SV=1,0,204.865,34,30,200,30,1267,139.4,5.76,89650,0,30,1,regulation of biological process,endoplasmic reticulum;membrane,protein binding,"Pf09430, Pf13620, Pf13715, Pf14686",283820,ENSG00000185164.14,NOMO2,16,,,,0,High,1
Q02338,"D-beta-hydroxybutyrate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=BDH1 PE=1 SV=3",0,204.648,59,17,846,17,343,38.1,8.95,397928,131.37,14,8,metabolic process,membrane;mitochondrion;organelle lumen,catalytic activity,Pf00106,622,ENSG00000275544.4; ENSG00000161267.11,BDH1,3; CHR_HSCHR3_2_CTG3,Metabolic pathways; Butanoate metabolism; Synthesis and degradation of ketone bodies,Synthesis and Degradation of Ketone Bodies,Synthesis of Ketone Bodies; Utilization of Ketone Bodies,9,High,1
Q15119,"[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial OS=Homo sapiens OX=9606 GN=PDK2 PE=1 SV=2",0,204.387,54,16,350,13,407,46.1,6.61,141017,93.64,13,6,cell communication;metabolic process;regulation of biological process;response to stimulus,cytosol;mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding,"Pf02518, Pf10436",5164,ENSG00000005882.11,PDK2,17,,,Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid,8,High,1
P53396,ATP-citrate synthase OS=Homo sapiens OX=9606 GN=ACLY PE=1 SV=3,0,204.357,36,32,264,32,1101,120.8,7.33,112642,0,32,1,metabolic process;regulation of biological process;transport,cytoplasm;cytosol;extracellular;membrane;organelle lumen,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00285, Pf00549, Pf02629, Pf08442",47,ENSG00000131473.16,ACLY,17,Metabolic pathways; Citrate cycle (TCA cycle),Sterol Regulatory Element-Binding Proteins (SREBP) signalling; TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc); Fatty Acid Biosynthesis; Amino Acid metabolism,ChREBP activates metabolic gene expression; Fatty acyl-CoA biosynthesis; Neutrophil degranulation,15,High,1
Q13557,Calcium/calmodulin-dependent protein kinase type II subunit delta OS=Homo sapiens OX=9606 GN=CAMK2D PE=1 SV=3,0,204.09,54,24,706,13,499,56.3,7.25,344862,13.79,22,5,cell differentiation;cell organization and biogenesis;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf07714, Pf08332, Pf12680, Pf13474, Pf14534",817,ENSG00000145349.16,CAMK2D,4,Neurotrophin signaling pathway; Melanogenesis; Cholinergic synapse; Dopaminergic synapse; Adrenergic signaling in cardiomyocytes; GnRH signaling pathway; Long-term potentiation; Oocyte meiosis; Olfactory transduction; Wnt signaling pathway; Amphetamine addiction; Tuberculosis; cAMP signaling pathway; Insulin secretion; Inflammatory mediator regulation of TRP channels; Circadian entrainment; Aldosterone synthesis and secretion; Calcium signaling pathway; Axon guidance; Gastric acid secretion; Proteoglycans in cancer; Glucagon signaling pathway; Glioma; ErbB signaling pathway; Oxytocin signaling pathway; HIF-1 signaling pathway,Physiological and Pathological Hypertrophy  of the Heart; MicroRNAs in cardiomyocyte hypertrophy; SRF and miRs in Smooth Muscle Differentiation and Proliferation; Cardiac Hypertrophic Response; Myometrial Relaxation and Contraction Pathways; Calcium Regulation in the Cardiac Cell,"Ion homeostasis; HSF1-dependent transactivation; Interferon gamma signaling; Phase 0 - rapid depolarisation; Ras activation uopn Ca2+ infux through NMDA receptor; Ion transport by P-type ATPases; Unblocking of NMDA receptor, glutamate binding and activation; Trafficking of AMPA receptors; CREB phosphorylation through the activation of CaMKII; RAF/MAP kinase cascade; Interleukin-20 family signaling",64,High,1
P00918,Carbonic anhydrase 2 OS=Homo sapiens OX=9606 GN=CA2 PE=1 SV=2,0,203.877,67,16,494,16,260,29.2,7.4,241594,0,16,3,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane,catalytic activity;metal ion binding;protein binding,Pf00194,760,ENSG00000104267.9,CA2,8,Gastric acid secretion; Bile secretion; Collecting duct acid secretion; Pancreatic secretion; Nitrogen metabolism; Proximal tubule bicarbonate reclamation,,Reversible hydration of carbon dioxide; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide,12,High,1
O60825-2,"Isoform 2 of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 OS=Homo sapiens OX=9606 GN=PFKFB2",0,203.769,59,26,404,1,471,54.4,7.56,187160,0,25,1,metabolic process;regulation of biological process;response to stimulus,cytosol,catalytic activity;nucleotide binding;protein binding,"Pf00300, Pf01591, Pf13207, Pf13671",5208,ENSG00000123836.14,PFKFB2,1,,Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,,1,High,1
P08865,40S ribosomal protein SA OS=Homo sapiens OX=9606 GN=RPSA PE=1 SV=4,0,203.471,59,15,367,15,295,32.8,4.87,191530,11.79,14,2,cell organization and biogenesis;metabolic process;transport,cytoplasm;cytosol;membrane;nucleus;ribosome,protein binding;receptor activity;RNA binding;structural molecule activity,Pf00318,3921,ENSG00000168028.13,RPSA,3,Ribosome,Cytoplasmic Ribosomal Proteins,"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane",38,High,1
Q9UNM6,26S proteasome non-ATPase regulatory subunit 13 OS=Homo sapiens OX=9606 GN=PSMD13 PE=1 SV=2,0,203.334,61,20,466,20,376,42.9,5.81,194714,0,20,2,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;extracellular;membrane;nucleus;organelle lumen;proteasome,catalytic activity;protein binding;structural molecule activity,Pf01399,5719,ENSG00000185627.17,PSMD13,11,Epstein-Barr virus infection; Proteasome,Proteasome Degradation; Parkin-Ubiquitin Proteasomal System pathway,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Neutrophil degranulation; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,153,High,1
P34913,Bifunctional epoxide hydrolase 2 OS=Homo sapiens OX=9606 GN=EPHX2 PE=1 SV=2,0,203.16,47,19,337,19,555,62.6,6.28,159779,24.89,18,3,cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,catalytic activity;metal ion binding;protein binding,"Pf00561, Pf00702, Pf12146, Pf12695, Pf12697, Pf13242, Pf13419",2053,ENSG00000120915.13,EPHX2,8,Peroxisome; Metabolic pathways; Arachidonic acid metabolism,Arachidonate Epoxygenase / Epoxide Hydrolase; Metapathway biotransformation,Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET),10,High,1
P30519,Heme oxygenase 2 OS=Homo sapiens OX=9606 GN=HMOX2 PE=1 SV=2,0,202.952,52,13,218,13,316,36,5.41,104590,0,13,1,cellular homeostasis;metabolic process;response to stimulus;transport,endoplasmic reticulum;membrane,catalytic activity;metal ion binding;protein binding,Pf01126,3163,ENSG00000103415.11; ENSG00000277424.4,HMOX2,16; CHR_HSCHR16_3_CTG1,Porphyrin and chlorophyll metabolism; Mineral absorption,,Heme degradation; Neutrophil degranulation; Iron uptake and transport,10,High,1
O75534-4,Isoform 4 of Cold shock domain-containing protein E1 OS=Homo sapiens OX=9606 GN=CSDE1,0,202.951,42,29,241,29,844,93.7,6.52,104849,21.92,26,5,metabolic process;regulation of biological process,cytosol;Golgi;membrane,DNA binding;protein binding;RNA binding,"Pf00313, Pf12901",7812,ENSG00000009307.15,CSDE1,1,,,,0,High,1
Q14432,"cGMP-inhibited 3',5'-cyclic phosphodiesterase A OS=Homo sapiens OX=9606 GN=PDE3A PE=1 SV=3",0,202.874,31,25,330,23,1141,124.9,6,149176,15.38,24,2,metabolic process;regulation of biological process;response to stimulus,cytosol;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding,Pf00233,5139,ENSG00000172572.6,PDE3A,12,Morphine addiction; Renin secretion; cAMP signaling pathway; Purine metabolism; cGMP-PKG signaling pathway,,G alpha (s) signalling events; cGMP effects,13,High,1
Q9P0L0-2,Isoform 2 of Vesicle-associated membrane protein-associated protein A OS=Homo sapiens OX=9606 GN=VAPA,0,202.791,50,15,576,13,294,32.6,8.91,260538,3.39,14,2,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoskeleton;endoplasmic reticulum;membrane,protein binding;signal transducer activity,Pf00635,9218,ENSG00000101558.13,VAPA,18,,Exercise-induced Circadian Regulation,,1,High,1
P43155,Carnitine O-acetyltransferase OS=Homo sapiens OX=9606 GN=CRAT PE=1 SV=5,0,202.65,39,22,737,22,626,70.8,8.44,368940,9.87,20,6,metabolic process;transport,endoplasmic reticulum;membrane;mitochondrion;organelle lumen,catalytic activity;protein binding,Pf00755,1384,ENSG00000095321.16,CRAT,9,Peroxisome,Fatty Acid Beta Oxidation,Beta-oxidation of pristanoyl-CoA,7,High,1
Q8NBX0,Saccharopine dehydrogenase-like oxidoreductase OS=Homo sapiens OX=9606 GN=SCCPDH PE=1 SV=1,0,202.302,55,18,444,18,429,47.1,9.14,206599,4.55,16,2,metabolic process;transport,extracellular;membrane;mitochondrion;nucleus;organelle lumen,catalytic activity,"Pf03435, Pf13460",51097,ENSG00000143653.9,SCCPDH,1,,,Platelet degranulation,4,High,1
Q96A65,Exocyst complex component 4 OS=Homo sapiens OX=9606 GN=EXOC4 PE=1 SV=1,0,202.103,39,27,176,27,974,110.4,6.49,79919,0,27,1,cell communication;cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytosol;membrane,protein binding,Pf04048,60412,ENSG00000131558.14,EXOC4,7,Tight junction,,Translocation of GLUT4 to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium,11,High,1
Q13439,Golgin subfamily A member 4 OS=Homo sapiens OX=9606 GN=GOLGA4 PE=1 SV=1,0,202.1,26,48,178,48,2230,261,5.39,71993,,48,,cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytosol;Golgi;membrane,protein binding,"Pf01465, Pf09731, Pf12128",2803,ENSG00000144674.16,GOLGA4,3,,,Retrograde transport at the Trans-Golgi-Network,4,High,1
O96000,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 OS=Homo sapiens OX=9606 GN=NDUFB10 PE=1 SV=3,0,202.039,60,18,880,18,172,20.8,8.48,466953,36.61,17,4,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion,catalytic activity;protein binding,Pf10249,4716,ENSG00000140990.14,NDUFB10,16,Oxidative phosphorylation; Huntington's disease; Metabolic pathways; Alzheimer's disease; Non-alcoholic fatty liver disease (NAFLD); Parkinson's disease,Electron Transport Chain; Oxidative phosphorylation,Complex I biogenesis,13,High,1
P0DJI8,Serum amyloid A-1 protein OS=Homo sapiens OX=9606 GN=SAA1 PE=1 SV=1,0,201.842,56,14,1166,5,122,13.5,6.79,603895,1.67,14,2,cellular component movement;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;organelle lumen,protein binding,Pf00277,6288,,SAA1,11,,Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism,Amyloid fiber formation; TRAF6 mediated NF-kB activation; G alpha (i) signalling events; Advanced glycosylation endproduct receptor signaling; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; RIP-mediated NFkB activation via ZBP1; Formyl peptide receptors bind formyl peptides and many other ligands; Activated TLR4 signalling; Interleukin-1 family signaling; Scavenging by Class B Receptors; Gastrin-CREB signalling pathway via PKC and MAPK; DEx/H-box helicases activate type I IFN and inflammatory cytokines production ; Interleukin-4 and 13 signaling,49,High,1
Q9Y262,Eukaryotic translation initiation factor 3 subunit L OS=Homo sapiens OX=9606 GN=EIF3L PE=1 SV=1,0,201.439,56,27,311,27,564,66.7,6.34,134513,1.66,27,6,metabolic process,cytoplasm;cytosol;membrane,protein binding;RNA binding,Pf10255,51386,ENSG00000100129.17,EIF3L,22,,,"Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Ribosomal scanning and start codon recognition",11,High,1
P36578,60S ribosomal protein L4 OS=Homo sapiens OX=9606 GN=RPL4 PE=1 SV=5,0,201.334,31,19,482,19,427,47.7,11.06,241697,0,19,2,cell organization and biogenesis;metabolic process;transport,cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;ribosome,protein binding;RNA binding;structural molecule activity,"Pf00573, Pf14374",6124,ENSG00000174444.14,RPL4,15,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
Q15118,"[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial OS=Homo sapiens OX=9606 GN=PDK1 PE=1 SV=1",0,200.808,49,20,392,16,436,49.2,8.81,177549,20.53,20,2,cell proliferation;metabolic process;regulation of biological process;response to stimulus,mitochondrion;nucleus;organelle lumen,catalytic activity;nucleotide binding;protein binding,"Pf02518, Pf10436",5163,ENSG00000152256.13,PDK1,2,Central carbon metabolism in cancer; Axon guidance; HIF-1 signaling pathway,T-Cell Receptor and Co-stimulatory Signaling; TGF-beta Signaling Pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection; EPO Receptor Signaling; ErbB Signaling Pathway; DNA Damage Response (only ATM dependent),Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid,19,High,1
P35998,26S proteasome regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PSMC2 PE=1 SV=3,0,200.753,55,23,533,23,433,48.6,5.95,258837,2.4,23,3,cell differentiation;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen;proteasome,catalytic activity;nucleotide binding;protein binding,"Pf00004, Pf00158, Pf07724, Pf07726, Pf07728, Pf13191, Pf13401",5701,ENSG00000161057.11,PSMC2,7,Epstein-Barr virus infection; Proteasome,Proteasome Degradation; Parkin-Ubiquitin Proteasomal System pathway,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Neutrophil degranulation; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,153,High,1
P09651,Heterogeneous nuclear ribonucleoprotein A1 OS=Homo sapiens OX=9606 GN=HNRNPA1 PE=1 SV=5,0,200.453,49,18,453,15,372,38.7,9.13,211319,4.87,17,4,cell communication;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;membrane;nucleus;spliceosomal complex,DNA binding;protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",3178,ENSG00000135486.17,HNRNPA1,12,Spliceosome,mRNA Processing,mRNA Splicing - Major Pathway; FGFR2 alternative splicing,11,High,1
P29401,Transketolase OS=Homo sapiens OX=9606 GN=TKT PE=1 SV=3,0,200.214,43,21,342,21,623,67.8,7.66,161944,,21,,metabolic process;regulation of biological process,cytosol,catalytic activity;metal ion binding;protein binding,"Pf00456, Pf00676, Pf02775, Pf02779, Pf02780, Pf09364",7086,ENSG00000163931.15,TKT,3,Carbon metabolism; Pentose phosphate pathway; Metabolic pathways; Biosynthesis of amino acids,Pentose Phosphate Pathway,Insulin effects increased synthesis of Xylulose-5-Phosphate; Pentose phosphate pathway (hexose monophosphate shunt),10,High,1
Q86WU2,"Probable D-lactate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=LDHD PE=1 SV=1",0,200.11,58,18,337,18,507,54.8,6.65,156289,61.92,13,10,metabolic process,membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding,"Pf01565, Pf02913",197257,ENSG00000166816.13,LDHD,16,Pyruvate metabolism,,Mitochondrial protein import; Metabolism of proteins,3,High,1
Q9UEY8-2,Isoform 1 of Gamma-adducin OS=Homo sapiens OX=9606 GN=ADD3,0,200.061,42,21,173,21,674,75.6,6.81,85033,4.72,20,2,cell organization and biogenesis;transport,chromosome;cytoskeleton;cytosol;membrane,protein binding;structural molecule activity,Pf00596,120,ENSG00000148700.14,ADD3,10,,,,0,High,1
P46976,Glycogenin-1 OS=Homo sapiens OX=9606 GN=GYG1 PE=1 SV=4,0,199.979,30,15,562,15,350,39.4,5.53,292078,13.55,14,2,metabolic process;transport,cytosol;extracellular;membrane;organelle lumen,catalytic activity;metal ion binding;protein binding,Pf01501,2992,ENSG00000163754.17,GYG1,3,Starch and sucrose metabolism; Metabolic pathways,Insulin Signaling; Glycogen Metabolism,Neutrophil degranulation; Glycogen storage disease type IV (GBE1); Glycogen storage disease type II (GAA); Glycogen storage disease type XV (GYG1); Glycogen breakdown (glycogenolysis); Lysosomal glycogen catabolism; Glycogen storage disease type 0 (muscle GYS1); Glycogen synthesis; Myoclonic epilepsy of Lafora,22,High,1
Q7Z4W1,L-xylulose reductase OS=Homo sapiens OX=9606 GN=DCXR PE=1 SV=2,0,199.801,72,19,821,19,244,25.9,8.1,381867,22.34,18,4,cell organization and biogenesis;metabolic process,membrane;nucleus,catalytic activity;protein binding,"Pf00106, Pf01488, Pf08659, Pf13460, Pf13561",51181,ENSG00000169738.7,DCXR,17,Pentose and glucuronate interconversions; Metabolic pathways,,Catabolism of glucuronate to xylulose-5-phosphate; Essential pentosuria,9,High,1
Q15019,Septin-2 OS=Homo sapiens OX=9606 GN=SEPTIN2 PE=1 SV=1,0,198.929,58,15,280,14,361,41.5,6.6,142571,1.65,15,1,cell differentiation;cell division;cell organization and biogenesis;regulation of biological process;response to stimulus,chromosome;cytoplasm;cytoskeleton;cytosol;membrane;nucleus,nucleotide binding;protein binding,"Pf00071, Pf00735, Pf01926",4735,ENSG00000168385.17,SEPT2,2,Bacterial invasion of epithelial cells,,Anchoring of the basal body to the plasma membrane,4,High,1
Q15111,Inactive phospholipase C-like protein 1 OS=Homo sapiens OX=9606 GN=PLCL1 PE=1 SV=3,0,198.848,31,26,239,24,1095,122.6,5.62,92446,40.9,23,10,metabolic process;regulation of biological process;response to stimulus,cytoplasm;membrane,catalytic activity;protein binding;signal transducer activity,"Pf00168, Pf00169, Pf00387, Pf00388, Pf09279",5334,ENSG00000115896.15,PLCL1,2,GABAergic synapse,GPR40 PATHWAY,,2,High,1
Q9Y263,Phospholipase A-2-activating protein OS=Homo sapiens OX=9606 GN=PLAA PE=1 SV=2,0,198.79,37,23,195,23,795,87.1,6.37,89316,2.32,23,2,cell communication;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,enzyme regulator activity;protein binding,"Pf00400, Pf08324, Pf09070",9373,ENSG00000137055.14,PLAA,9,Protein processing in endoplasmic reticulum,,,1,High,1
Q13619,Cullin-4A OS=Homo sapiens OX=9606 GN=CUL4A PE=1 SV=3,0,198.538,43,31,286,22,759,87.6,8.13,129368,,31,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,,catalytic activity;protein binding,"Pf00888, Pf10557",8451,ENSG00000139842.14,CUL4A,13,Nucleotide excision repair; Ubiquitin mediated proteolysis,,Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual incision in TC-NER; Formation of TC-NER Pre-Incision Complex; Dual Incision in GG-NER; Neddylation,17,High,1
P11940,Polyadenylate-binding protein 1 OS=Homo sapiens OX=9606 GN=PABPC1 PE=1 SV=2,0,198.143,51,26,421,17,636,70.6,9.5,187883,0,26,2,metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;nucleus;spliceosomal complex,protein binding;RNA binding;translation regulator activity,"Pf00076, Pf00658, Pf13893, Pf14259",26986,ENSG00000070756.15,PABPC1,8,RNA transport; mRNA surveillance pathway; RNA degradation,Translation Factors; Endoderm Differentiation,AUF1 (hnRNP D0) binds and destabilizes mRNA; L13a-mediated translational silencing of Ceruloplasmin expression; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Deadenylation of mRNA,24,High,1
Q02818,Nucleobindin-1 OS=Homo sapiens OX=9606 GN=NUCB1 PE=1 SV=4,0,198.139,53,21,223,21,461,53.8,5.25,108047,0,21,1,metabolic process;regulation of biological process;response to stimulus,cytoplasm;endoplasmic reticulum;endosome;extracellular;Golgi;membrane;nucleus;organelle lumen,DNA binding;metal ion binding;protein binding,,4924,ENSG00000104805.15,NUCB1,19,,,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs),4,High,1
Q08426,Peroxisomal bifunctional enzyme OS=Homo sapiens OX=9606 GN=EHHADH PE=1 SV=3,0,198.111,50,29,247,29,723,79.4,9.14,110780,,29,,metabolic process,cytosol;mitochondrion;organelle lumen,catalytic activity;protein binding,"Pf00378, Pf00725, Pf02737",1962,ENSG00000113790.10,EHHADH,3,"Carbon metabolism; Fatty acid metabolism; PPAR signaling pathway; Fatty acid degradation; Tryptophan metabolism; Butanoate metabolism; beta-Alanine metabolism; Lysine degradation; Propanoate metabolism; Valine, leucine and isoleucine degradation; Peroxisome; Metabolic pathways",Constitutive Androstane Receptor Pathway; PPAR Alpha Pathway; Mitochondrial LC-Fatty Acid Beta-Oxidation; Valproic acid pathway; Amino Acid metabolism; PPAR signaling pathway,Beta-oxidation of very long chain fatty acids,23,High,1
Q07866-6,Isoform N of Kinesin light chain 1 OS=Homo sapiens OX=9606 GN=KLC1,0,197.896,40,21,187,15,628,71,6.67,91630,2.18,20,2,cell organization and biogenesis;cellular component movement;transport,cytosol;membrane,catalytic activity;motor activity;protein binding,"Pf08317, Pf09311, Pf13374, Pf13414, Pf13424, Pf14559",3831,ENSG00000126214.21,KLC1,14,,,,0,High,1
P07585,Decorin OS=Homo sapiens OX=9606 GN=DCN PE=1 SV=1,0,197.846,35,17,774,17,359,39.7,8.54,398928,3.52,17,4,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;extracellular;organelle lumen,enzyme regulator activity;protein binding;RNA binding,"Pf01462, Pf12799, Pf13855",1634,ENSG00000011465.16,DCN,12,TGF-beta signaling pathway; Proteoglycans in cancer,BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation,"ECM proteoglycans; A tetrasaccharide linker sequence is required for GAG synthesis; Dermatan sulfate biosynthesis; Degradation of the extracellular matrix; Defective CHSY1 causes TPBS; Defective B4GALT7 causes EDS, progeroid type; Defective B3GALT6 causes EDSP2 and SEMDJL1; CS/DS degradation; Defective CHST14 causes EDS, musculocontractural type; Defective CHST3 causes SEDCJD; Chondroitin sulfate biosynthesis; Defective B3GAT3 causes JDSSDHD",24,High,1
O95573,Long-chain-fatty-acid--CoA ligase 3 OS=Homo sapiens OX=9606 GN=ACSL3 PE=1 SV=3,0,197.817,41,24,180,23,720,80.4,8.38,77009,0,24,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;Golgi;membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding,Pf00501,2181,ENSG00000123983.13,ACSL3,2,PPAR signaling pathway; Metabolic pathways; Fatty acid degradation; Adipocytokine signaling pathway; Fatty acid metabolism; Fatty acid biosynthesis; Peroxisome,Fatty Acid Beta Oxidation; Fatty Acid Biosynthesis; Mitochondrial LC-Fatty Acid Beta-Oxidation; PPAR signaling pathway,Synthesis of very long-chain fatty acyl-CoAs,16,High,1
Q9NP81,"Serine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=SARS2 PE=1 SV=1",0,197.816,46,18,273,18,518,58.2,8.13,125751,1.71,18,2,cell organization and biogenesis;metabolic process,cytoplasm;cytoskeleton;mitochondrion;organelle lumen,catalytic activity;nucleotide binding;RNA binding,"Pf00587, Pf02403, Pf06160",54938,ENSG00000283104.1; ENSG00000104835.14,SARS2,19; CHR_HG26_PATCH,Aminoacyl-tRNA biosynthesis,Selenium Metabolism and Selenoproteins,Mitochondrial tRNA aminoacylation,6,High,1
Q9Y265,RuvB-like 1 OS=Homo sapiens OX=9606 GN=RUVBL1 PE=1 SV=1,0,197.79,50,20,324,20,456,50.2,6.42,156526,5.21,20,4,cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00004, Pf01078, Pf01695, Pf05496, Pf06068, Pf06414, Pf07726, Pf13191, Pf13238, Pf13245, Pf13481",8607,ENSG00000175792.11,RUVBL1,3,Wnt signaling pathway,Gastric Cancer Network 1,Ub-specific processing proteases; UCH proteinases; DNA Damage Recognition in GG-NER; HATs acetylate histones; Formation of the beta-catenin:TCF transactivating complex; Telomere Extension By Telomerase; Deposition of new CENPA-containing nucleosomes at the centromere,25,High,1
P0CAP1,Myocardial zonula adherens protein OS=Homo sapiens OX=9606 GN=MYZAP PE=1 SV=1,0,197.42,65,26,275,3,466,54.2,6.18,138596,4.24,25,2,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;membrane,catalytic activity;motor activity;protein binding,"Pf01576, Pf05622, Pf12128, Pf13166, Pf15328",145781; 100820829; 81488,ENSG00000263155.5; ENSG00000137878.16,GCOM1; MYZAP; POLR2M,15,,,,0,High,1
Q08431,Lactadherin OS=Homo sapiens OX=9606 GN=MFGE8 PE=1 SV=3,0,197.325,47,18,356,18,387,43.1,8.15,155047,2.21,18,4,,,,,,,,,,,,0,High,1
P54289,Voltage-dependent calcium channel subunit alpha-2/delta-1 OS=Homo sapiens OX=9606 GN=CACNA2D1 PE=1 SV=3,0,197.17,30,25,243,1,1103,124.5,5.27,111881,2.5,24,2,cellular homeostasis;regulation of biological process;transport,endoplasmic reticulum;membrane,metal ion binding;transporter activity,"Pf00092, Pf02743, Pf08399, Pf08473, Pf13519, Pf13768",781,ENSG00000153956.15,CACNA2D1,7,Oxytocin signaling pathway; Adrenergic signaling in cardiomyocytes; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Cardiac muscle contraction; Dilated cardiomyopathy; Hypertrophic cardiomyopathy (HCM); MAPK signaling pathway,Arrhythmogenic Right Ventricular Cardiomyopathy,Phase 0 - rapid depolarisation; Phase 2 - plateau phase,12,High,1
P35606,Coatomer subunit beta' OS=Homo sapiens OX=9606 GN=COPB2 PE=1 SV=2,0,197.065,36,26,254,26,906,102.4,5.27,113664,,26,,transport,cytoplasm;cytosol;Golgi;membrane,protein binding;structural molecule activity,"Pf00400, Pf04053",9276,ENSG00000184432.9,COPB2,3,,,COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport,11,High,1
Q9NNW7,"Thioredoxin reductase 2, mitochondrial OS=Homo sapiens OX=9606 GN=TXNRD2 PE=1 SV=3",0,196.923,40,15,215,15,524,56.5,7.5,97723,47.94,14,2,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cytosol;mitochondrion;organelle lumen,antioxidant activity;catalytic activity;nucleotide binding;protein binding,"Pf00070, Pf02852, Pf07992, Pf13738",10587,ENSG00000184470.20,TXNRD2,22,Pyrimidine metabolism; Selenocompound metabolism,Selenium Micronutrient Network; Selenium Metabolism and Selenoproteins; Oxidative Stress,Detoxification of Reactive Oxygen Species,8,High,1
P12429,Annexin A3 OS=Homo sapiens OX=9606 GN=ANXA3 PE=1 SV=3,0,196.803,57,19,452,19,323,36.4,5.92,219442,2.97,19,6,defense response;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane,enzyme regulator activity;metal ion binding;protein binding,Pf00191,306,ENSG00000138772.12,ANXA3,4,,Prostaglandin Synthesis and Regulation,,1,High,1
Q6ZVM7-5,Isoform 5 of TOM1-like protein 2 OS=Homo sapiens OX=9606 GN=TOM1L2,0,196.684,47,21,202,1,483,53.3,4.79,95902,7.54,20,2,regulation of biological process;response to stimulus;transport,,protein binding,"Pf00790, Pf01417, Pf03127",146691,ENSG00000175662.17,TOM1L2,17,,,,0,High,1
P51398,"28S ribosomal protein S29, mitochondrial OS=Homo sapiens OX=9606 GN=DAP3 PE=1 SV=1",0,196.516,50,20,289,19,398,45.5,8.88,127818,0,20,1,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,membrane;mitochondrion;ribosome,nucleotide binding;protein binding;RNA binding;structural molecule activity,Pf10236,7818,ENSG00000132676.15,DAP3,1,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
P56192,"Methionine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=MARS PE=1 SV=2",0,196.396,31,25,216,25,900,101.1,6.16,91416,0,24,2,cell communication;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00043, Pf00133, Pf00458, Pf09334, Pf10978, Pf13409, Pf13410, Pf14497",4141,ENSG00000166986.14,MARS,12,Selenocompound metabolism; Aminoacyl-tRNA biosynthesis,,Cytosolic tRNA aminoacylation; SeMet incorporation into proteins,10,High,1
P50416,"Carnitine O-palmitoyltransferase 1, liver isoform OS=Homo sapiens OX=9606 GN=CPT1A PE=1 SV=2",0,196.118,35,25,242,24,773,88.3,8.65,110182,1.69,25,3,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,membrane;mitochondrion,catalytic activity;protein binding,Pf00755,1374,ENSG00000110090.12,CPT1A,11,Adipocytokine signaling pathway; Glucagon signaling pathway; Fatty acid metabolism; AMPK signaling pathway; Fatty acid degradation; Insulin resistance; PPAR signaling pathway,AMP-activated Protein Kinase (AMPK) Signaling; Fatty Acid Beta Oxidation; PPAR Alpha Pathway; Mitochondrial LC-Fatty Acid Beta-Oxidation; Leptin and adiponectin; PPAR signaling pathway; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,RORA activates gene expression; Signaling by Retinoic Acid; Import of palmitoyl-CoA into the mitochondrial matrix; PPARA activates gene expression,25,High,1
Q99613,Eukaryotic translation initiation factor 3 subunit C OS=Homo sapiens OX=9606 GN=EIF3C PE=1 SV=1,0,195.932,29,23,230,23,913,105.3,5.68,105562,0,23,3,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol,protein binding;RNA binding,"Pf01399, Pf05470",8663,ENSG00000184110.14,EIF3C,16,RNA transport,Translation Factors,"Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Ribosomal scanning and start codon recognition",13,High,1
Q92947,"Glutaryl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=GCDH PE=1 SV=1",0,195.529,39,14,470,14,438,48.1,8.06,216074,2.09,14,1,metabolic process,mitochondrion;organelle lumen,catalytic activity;nucleotide binding,"Pf00441, Pf02770, Pf02771, Pf08028",2639,ENSG00000105607.12,GCDH,19,Tryptophan metabolism; Fatty acid degradation; Metabolic pathways; Lysine degradation,Fatty Acid Beta Oxidation; Tryptophan metabolism,Lysine catabolism,10,High,1
P61204,ADP-ribosylation factor 3 OS=Homo sapiens OX=9606 GN=ARF3 PE=1 SV=2,0,195.512,64,12,849,6,181,20.6,7.43,428387,3.86,12,3,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;Golgi;membrane,catalytic activity;nucleotide binding;protein binding;signal transducer activity,"Pf00025, Pf00071, Pf00503, Pf01926, Pf04670, Pf08477, Pf09439",377,ENSG00000134287.9,ARF3,12,Endocytosis,,Synthesis of PIPs at the Golgi membrane; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport,17,High,1
P20618,Proteasome subunit beta type-1 OS=Homo sapiens OX=9606 GN=PSMB1 PE=1 SV=2,0,195.368,63,20,350,20,241,26.5,8.13,158684,1.77,20,2,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;nucleus;organelle lumen;proteasome,catalytic activity;protein binding,Pf00227,5689,ENSG00000008018.8,PSMB1,6,Proteasome,Proteasome Degradation,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Neutrophil degranulation; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,151,High,1
P78559,Microtubule-associated protein 1A OS=Homo sapiens OX=9606 GN=MAP1A PE=1 SV=6,0,195.192,22,38,152,37,2803,305.3,4.92,59130,0,38,1,cell organization and biogenesis,cytoplasm;cytoskeleton,protein binding;structural molecule activity,"Pf12072, Pf12128",4130,ENSG00000166963.12,MAP1A,15,,,,0,High,1
P22102,Trifunctional purine biosynthetic protein adenosine-3 OS=Homo sapiens OX=9606 GN=GART PE=1 SV=1,0,195.055,35,25,384,25,1010,107.7,6.7,187334,,25,,metabolic process;response to stimulus,cytoplasm;cytosol,catalytic activity;metal ion binding;nucleotide binding,"Pf00551, Pf00586, Pf01071, Pf02222, Pf02655, Pf02769, Pf02843, Pf02844, Pf03435, Pf07478, Pf08442, Pf08443, Pf13535, Pf15632",2618,ENSG00000159131.16,GART,21,One carbon pool by folate; Antifolate resistance; Metabolic pathways; Purine metabolism,Folate Metabolism; One Carbon Metabolism,Purine ribonucleoside monophosphate biosynthesis,10,High,1
P07858,Cathepsin B OS=Homo sapiens OX=9606 GN=CTSB PE=1 SV=3,0,195.046,39,14,561,14,339,37.8,6.3,267845,44.18,12,4,cell differentiation;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;mitochondrion;organelle lumen;vacuole,catalytic activity;protein binding,"Pf00112, Pf08127",1508,ENSG00000164733.20,CTSB,8,Apoptosis; Lysosome; Antigen processing and presentation; NOD-like receptor signaling pathway; Renin secretion,,Collagen degradation; Assembly of collagen fibrils and other multimeric structures; Neutrophil degranulation; MHC class II antigen presentation; Trafficking and processing of endosomal TLR,17,High,1
Q13554,Calcium/calmodulin-dependent protein kinase type II subunit beta OS=Homo sapiens OX=9606 GN=CAMK2B PE=1 SV=3,0,194.671,40,23,605,9,666,72.6,7.27,305019,4.51,22,3,cell differentiation;development;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf07714, Pf08332, Pf12680, Pf13474, Pf14534",816,ENSG00000058404.19,CAMK2B,7,Glioma; Inflammatory mediator regulation of TRP channels; ErbB signaling pathway; Aldosterone synthesis and secretion; Oxytocin signaling pathway; Melanogenesis; Calcium signaling pathway; HIF-1 signaling pathway; Adrenergic signaling in cardiomyocytes; Axon guidance; Long-term potentiation; Gastric acid secretion; Olfactory transduction; Proteoglycans in cancer; Amphetamine addiction; Glucagon signaling pathway; Cholinergic synapse; GnRH signaling pathway; Oocyte meiosis; Wnt signaling pathway; Tuberculosis; Insulin secretion; Circadian entrainment; Neurotrophin signaling pathway; Dopaminergic synapse; cAMP signaling pathway,Primary Focal Segmental Glomerulosclerosis FSGS; Myometrial Relaxation and Contraction Pathways; Serotonin and anxiety; Calcium Regulation in the Cardiac Cell,"Ion homeostasis; HSF1-dependent transactivation; Interferon gamma signaling; Phase 0 - rapid depolarisation; Ras activation uopn Ca2+ infux through NMDA receptor; Ion transport by P-type ATPases; Unblocking of NMDA receptor, glutamate binding and activation; Trafficking of AMPA receptors; CREB phosphorylation through the activation of CaMKII; RAF/MAP kinase cascade; Interleukin-20 family signaling",62,High,1
Q9BT78,COP9 signalosome complex subunit 4 OS=Homo sapiens OX=9606 GN=COPS4 PE=1 SV=1,0,194.578,58,20,294,20,406,46.2,5.83,128884,3.53,19,1,cell organization and biogenesis;metabolic process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,Pf01399,51138,ENSG00000138663.8,COPS4,4,,,Cargo recognition for clathrin-mediated endocytosis; DNA Damage Recognition in GG-NER; Formation of TC-NER Pre-Incision Complex; Neddylation,13,High,1
P56556,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 OS=Homo sapiens OX=9606 GN=NDUFA6 PE=1 SV=4,0,194.297,53,18,1357,18,128,15.1,9.98,706599,4.16,17,2,cell organization and biogenesis;metabolic process;response to stimulus;transport,membrane;mitochondrion,catalytic activity,"Pf05347, Pf13232, Pf13233",4700,ENSG00000281013.2; ENSG00000184983.9; ENSG00000277365.3; ENSG00000273397.4,NDUFA6,22; CHR_HSCHR22_4_CTG1; CHR_HSCHR22_3_CTG1; CHR_HSCHR22_2_CTG1,,Electron Transport Chain; Oxidative phosphorylation,,2,High,1
Q8NCN5,"Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial OS=Homo sapiens OX=9606 GN=PDPR PE=1 SV=2",0,194.28,31,27,410,27,879,99.3,6.35,183589,2.42,27,3,metabolic process;regulation of biological process,mitochondrion;organelle lumen,catalytic activity,"Pf01266, Pf01571, Pf08669",55066,ENSG00000090857.13,PDPR,16,,,Regulation of pyruvate dehydrogenase (PDH) complex,5,High,1
Q04695,"Keratin, type I cytoskeletal 17 OS=Homo sapiens OX=9606 GN=KRT17 PE=1 SV=2",0,193.999,50,29,611,11,432,48.1,5.02,322104,0,29,2,cell death;cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol,protein binding;receptor activity;signal transducer activity;structural molecule activity,"Pf00038, Pf07888",3872,ENSG00000128422.15,KRT17,17,,,Formation of the cornified envelope,3,High,1
P00325,All-trans-retinol dehydrogenase [NAD(+)] ADH1B OS=Homo sapiens OX=9606 GN=ADH1B PE=1 SV=2,0,193.997,52,18,512,10,375,39.8,8.29,222171,179.13,15,4,metabolic process,cytoplasm;cytosol;membrane,catalytic activity;metal ion binding,"Pf00107, Pf08240",125,,ADH1B,4,Drug metabolism - cytochrome P450; Fatty acid degradation; Chemical carcinogenesis; Tyrosine metabolism; Glycolysis / Gluconeogenesis; Metabolism of xenobiotics by cytochrome P450; Metabolic pathways; Retinol metabolism,Fatty Acid Omega Oxidation,Ethanol oxidation,13,High,1
P25325,3-mercaptopyruvate sulfurtransferase OS=Homo sapiens OX=9606 GN=MPST PE=1 SV=3,0,193.944,62,14,385,13,297,33.2,6.6,191595,0,14,1,metabolic process;response to stimulus,cytoplasm;cytosol;mitochondrion,catalytic activity;protein binding,Pf00581,4357,ENSG00000128309.16,MPST,22,Cysteine and methionine metabolism; Sulfur relay system; Metabolic pathways; Sulfur metabolism,Trans-sulfuration pathway; Amino Acid metabolism,,6,High,1
P30044,"Peroxiredoxin-5, mitochondrial OS=Homo sapiens OX=9606 GN=PRDX5 PE=1 SV=4",0,193.535,68,16,1093,16,214,22.1,8.7,567931,22.41,14,5,cell death;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;mitochondrion;nucleus;organelle lumen,antioxidant activity;catalytic activity;DNA binding;enzyme regulator activity;protein binding,"Pf00578, Pf08534",25824,ENSG00000126432.13,PRDX5,11,Peroxisome,Selenium Micronutrient Network,Detoxification of Reactive Oxygen Species,5,High,1
P49773,Histidine triad nucleotide-binding protein 1 OS=Homo sapiens OX=9606 GN=HINT1 PE=1 SV=2,0,193.357,71,11,597,11,126,13.8,6.95,260121,44.65,10,2,cell death;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf01230, Pf11969",3094,ENSG00000169567.11,HINT1,5,,,,0,High,1
P62701,"40S ribosomal protein S4, X isoform OS=Homo sapiens OX=9606 GN=RPS4X PE=1 SV=2",0,193.191,56,22,900,22,263,29.6,10.15,419513,11.58,21,1,cell organization and biogenesis;development;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;membrane;ribosome,protein binding;RNA binding;structural molecule activity,"Pf00900, Pf08071",6191,ENSG00000198034.10,RPS4X,X,Ribosome,Cytoplasmic Ribosomal Proteins,"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane",38,High,1
P0CAP1-11,Isoform 11 of Myocardial zonula adherens protein OS=Homo sapiens OX=9606 GN=MYZAP,0,192.645,54,24,266,1,550,64,5.88,135135,2.14,24,1,metabolic process;regulation of biological process;response to stimulus,cytoskeleton,catalytic activity;motor activity;protein binding,"Pf01576, Pf05622, Pf13166, Pf15328",145781; 100820829; 81488,ENSG00000137878.16,GCOM1; MYZAP; POLR2M,15,,,,0,High,1
P06753-5,Isoform 5 of Tropomyosin alpha-3 chain OS=Homo sapiens OX=9606 GN=TPM3,0,192.1,44,21,3442,4,248,28.9,4.75,1877833,143.38,17,9,cell organization and biogenesis;cellular component movement,cytoskeleton;cytosol,protein binding;structural molecule activity,"Pf00261, Pf12718",7170,ENSG00000143549.19,TPM3,1,,Striated Muscle Contraction,,1,High,1
Q15046,Lysine--tRNA ligase OS=Homo sapiens OX=9606 GN=KARS1 PE=1 SV=3,0,191.838,36,22,378,22,597,68,6.35,174577,16.21,21,4,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;extracellular;membrane;mitochondrion;nucleus;organelle lumen,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00152, Pf00587, Pf01336",3735,ENSG00000065427.14,KARS,16,Aminoacyl-tRNA biosynthesis,,Mitochondrial tRNA aminoacylation; Cytosolic tRNA aminoacylation; SeMet incorporation into proteins,10,High,1
Q9ULA0,Aspartyl aminopeptidase OS=Homo sapiens OX=9606 GN=DNPEP PE=1 SV=1,0,191.728,43,18,378,18,475,52.4,7.42,180155,11.97,18,2,metabolic process,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;protein binding,"Pf02127, Pf05343",23549,,DNPEP,2,,,,0,High,1
Q92597,Protein NDRG1 OS=Homo sapiens OX=9606 GN=NDRG1 PE=1 SV=1,0,191.604,40,9,206,9,394,42.8,5.82,101195,,9,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,protein binding,"Pf00561, Pf03096, Pf12697",10397,ENSG00000104419.14,NDRG1,8,,VEGFA-VEGFR2 Signaling Pathway,TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain,7,High,1
Q9UH99,SUN domain-containing protein 2 OS=Homo sapiens OX=9606 GN=SUN2 PE=1 SV=3,0,191.585,33,18,224,18,717,80.3,6.73,100622,,18,,cell organization and biogenesis;cellular component movement;regulation of biological process;transport,chromosome;endosome;membrane;nucleus,protein binding,Pf07738,25777,ENSG00000100242.15,SUN2,22,,,Meiotic synapsis,4,High,1
A0FGR8,Extended synaptotagmin-2 OS=Homo sapiens OX=9606 GN=ESYT2 PE=1 SV=1,0,191.396,40,24,211,24,921,102.3,9.26,98763,0,24,1,metabolic process;transport,endoplasmic reticulum;membrane,metal ion binding;protein binding,Pf00168,57488,,ESYT2,7,,,Glycosphingolipid metabolism,4,High,1
P52209,"6-phosphogluconate dehydrogenase, decarboxylating OS=Homo sapiens OX=9606 GN=PGD PE=1 SV=3",0,191.058,44,21,383,20,483,53.1,7.23,186691,0,21,1,metabolic process,cytoplasm;cytosol;nucleus,catalytic activity,"Pf00393, Pf03446",5226,ENSG00000142657.20,PGD,1,Pentose phosphate pathway; Carbon metabolism; Metabolic pathways; Glutathione metabolism,Pentose Phosphate Pathway; NRF2 pathway,Pentose phosphate pathway (hexose monophosphate shunt),9,High,1
Q15084,Protein disulfide-isomerase A6 OS=Homo sapiens OX=9606 GN=PDIA6 PE=1 SV=1,0,190.994,45,16,534,16,440,48.1,5.08,280912,0,16,1,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;endoplasmic reticulum;membrane;organelle lumen,catalytic activity;protein binding,"Pf00085, Pf13098, Pf13848, Pf13899, Pf13905",10130,ENSG00000143870.12,PDIA6,2,Protein processing in endoplasmic reticulum,Photodynamic therapy-induced unfolded protein response,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); XBP1(S) activates chaperone genes,9,High,1
Q9NUJ1,"Mycophenolic acid acyl-glucuronide esterase, mitochondrial OS=Homo sapiens OX=9606 GN=ABHD10 PE=1 SV=1",0,190.561,49,16,672,16,306,33.9,8.57,324747,0,16,1,metabolic process,cytosol;mitochondrion;organelle lumen,catalytic activity,"Pf00326, Pf00561, Pf12695, Pf12697",55347,ENSG00000144827.8,ABHD10,3,,,Glucuronidation,4,High,1
Q9NTJ5,Phosphatidylinositide phosphatase SAC1 OS=Homo sapiens OX=9606 GN=SACM1L PE=1 SV=2,0,190.439,46,27,295,26,587,66.9,7.12,135830,,27,,metabolic process,endoplasmic reticulum;Golgi;membrane,catalytic activity;protein binding;receptor activity;signal transducer activity,Pf02383,22908,ENSG00000211456.10,SACM1L,3,,,Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the ER membrane,6,High,1
P78417,Glutathione S-transferase omega-1 OS=Homo sapiens OX=9606 GN=GSTO1 PE=1 SV=2,0,190.221,57,18,1321,18,241,27.5,6.6,625252,27.75,17,7,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,antioxidant activity;catalytic activity;protein binding,"Pf00043, Pf00462, Pf02798, Pf13409, Pf13417, Pf14497",9446,ENSG00000148834.12,GSTO1,10,Chemical carcinogenesis; Glutathione metabolism; Drug metabolism - cytochrome P450; Platinum drug resistance; Metabolism of xenobiotics by cytochrome P450,Myometrial Relaxation and Contraction Pathways; Metapathway biotransformation,Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Glutathione conjugation; Methylation; Vitamin C (ascorbate) metabolism; Interleukin-12 family signaling,20,High,1
P07996,Thrombospondin-1 OS=Homo sapiens OX=9606 GN=THBS1 PE=1 SV=2,0,190.181,23,23,245,22,1170,129.3,4.94,111519,0,23,2,cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;endoplasmic reticulum;extracellular;organelle lumen,metal ion binding;protein binding,"Pf00090, Pf00093, Pf02412, Pf05735, Pf12947",7057,ENSG00000137801.10,THBS1,15,p53 signaling pathway; Phagosome; PI3K-Akt signaling pathway; Malaria; MicroRNAs in cancer; Bladder cancer; Proteoglycans in cancer; Focal adhesion; Rap1 signaling pathway; ECM-receptor interaction; TGF-beta signaling pathway,Bladder Cancer; Apoptosis-related network due to altered Notch3 in ovarian cancer; miRNA targets in ECM and membrane receptors; Focal Adhesion; TGF-beta Signaling Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Inflammatory Response Pathway; TGF-beta Receptor Signaling; Senescence and Autophagy in Cancer,Platelet degranulation ; Integrin cell surface interactions; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Defective B3GALTL causes Peters-plus syndrome (PpS); O-glycosylation of TSR domain-containing proteins; Signaling by PDGF; Syndecan interactions,44,High,1
Q15366,Poly(rC)-binding protein 2 OS=Homo sapiens OX=9606 GN=PCBP2 PE=1 SV=1,0,190.118,49,15,345,10,365,38.6,6.79,174965,13.28,14,2,defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,DNA binding;protein binding;RNA binding,"Pf00013, Pf13014",5094,ENSG00000197111.15,PCBP2,12,,mRNA Processing,Negative regulators of DDX58/IFIH1 signaling; mRNA Splicing - Major Pathway,9,High,1
O43852-4,Isoform 4 of Calumenin OS=Homo sapiens OX=9606 GN=CALU,0,189.882,55,16,313,1,323,38.1,4.58,149850,30.3,15,2,metabolic process,endoplasmic reticulum;extracellular;Golgi;membrane;organelle lumen,metal ion binding;protein binding,Pf13499,813,ENSG00000128595.16,CALU,7,,NOTCH1 regulation of human endothelial cell calcification,,1,High,1
P19338,Nucleolin OS=Homo sapiens OX=9606 GN=NCL PE=1 SV=3,0,189.521,31,23,464,23,710,76.6,4.7,227040,0,23,2,regulation of biological process;response to stimulus,cytoplasm;membrane;nucleus,DNA binding;protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",4691,ENSG00000115053.15,NCL,2,Pathogenic Escherichia coli infection,Pathogenic Escherichia coli infection; VEGFA-VEGFR2 Signaling Pathway,Major pathway of rRNA processing in the nucleolus and cytosol,7,High,1
P00352,Retinal dehydrogenase 1 OS=Homo sapiens OX=9606 GN=ALDH1A1 PE=1 SV=2,0,189.482,48,21,466,18,501,54.8,6.73,234806,0,21,2,metabolic process;regulation of biological process,cytoplasm;cytosol,catalytic activity;enzyme regulator activity;nucleotide binding,"Pf00171, Pf05893, Pf07368",216,ENSG00000165092.12,ALDH1A1,9,Retinol metabolism; Metabolic pathways,Folate-Alcohol and Cancer Pathway; Fatty Acid Omega Oxidation; Dopaminergic Neurogenesis; Amino Acid metabolism; Tryptophan metabolism; Vitamin A and Carotenoid Metabolism,Ethanol oxidation; Fructose catabolism; RA biosynthesis pathway,19,High,1
P0DP25,Calmodulin-3 OS=Homo sapiens OX=9606 GN=CALM3 PE=1 SV=1,0,189.45,93,14,884,12,149,16.8,4.22,460163,0,14,2,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;extracellular;membrane,catalytic activity;enzyme regulator activity;metal ion binding;protein binding;transporter activity,"Pf00036, Pf08726, Pf12763, Pf13202, Pf13405, Pf13499, Pf13833, Pf14658",808; 805; 801,ENSG00000160014.16; ENSG00000143933.16; ENSG00000198668.10,CALM3; CALM2; CALM1,19; 2; 14,Alcoholism; Estrogen signaling pathway; Vascular smooth muscle contraction; cGMP-PKG signaling pathway; Oxytocin signaling pathway; Long-term potentiation; Tuberculosis; Melanogenesis; Gastric acid secretion; Inflammatory mediator regulation of TRP channels; cAMP signaling pathway; Phototransduction; Amphetamine addiction; Rap1 signaling pathway; Circadian entrainment; Adrenergic signaling in cardiomyocytes; Pertussis; Oocyte meiosis; Salivary secretion; GnRH signaling pathway; Dopaminergic synapse; Insulin signaling pathway; Neurotrophin signaling pathway; Olfactory transduction; Phosphatidylinositol signaling system; Glucagon signaling pathway; Aldosterone synthesis and secretion; Ras signaling pathway; Calcium signaling pathway; Renin secretion; Glioma; Alzheimer's disease,Physiological and Pathological Hypertrophy  of the Heart; MicroRNAs in cardiomyocyte hypertrophy; Alzheimers Disease; Endothelin Pathways; T-Cell Receptor and Co-stimulatory Signaling; Common Pathways Underlying Drug Addiction; Cardiac Hypertrophic Response; Myometrial Relaxation and Contraction Pathways; Melatonin metabolism and effects; G Protein Signaling Pathways; T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection; Endochondral Ossification; Glycogen Metabolism; G13 Signaling Pathway; Calcium Regulation in the Cardiac Cell,"Smooth Muscle Contraction; Uptake and function of anthrax toxins; Stimuli-sensing channels; Translocation of GLUT4 to the plasma membrane; Synthesis of IP3 and IP4 in the cytosol; Reduction of cytosolic Ca++ levels; CREB phosphorylation through the activation of CaMKII; Ion homeostasis; Ca2+ pathway; Phase 0 - rapid depolarisation; Calcineurin activates NFAT; Platelet degranulation ; eNOS activation; VEGFR2 mediated vascular permeability; VEGFR2 mediated cell proliferation; CaMK IV-mediated phosphorylation of CREB; Activation of CaMK IV; RAF/MAP kinase cascade; Inactivation, recovery and regulation of the phototransduction cascade; FCERI mediated Ca+2 mobilization; Cam-PDE 1 activation; Glycogen breakdown (glycogenolysis); Signaling by GPCR; Sodium/Calcium exchangers; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Interleukin-20 family signaling; RHO GTPases activate PAKs; Protein methylation; DARPP-32 events; RHO GTPases activate IQGAPs; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; Ras activation uopn Ca2+ infux through NMDA receptor; PKA activation; Ion transport by P-type ATPases; Transcriptional activation of mitochondrial biogenesis; Activation of Ca-permeable Kainate Receptor; CLEC7A (Dectin-1) induces NFAT activation",150,High,1
P82909,"28S ribosomal protein S36, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS36 PE=1 SV=2",0,189.32,73,14,1171,14,103,11.5,9.99,633229,3.27,13,4,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,structural molecule activity,,92259,ENSG00000278461.4; ENSG00000134056.11,MRPS36,5; CHR_HSCHR5_2_CTG1_1,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
P47755,F-actin-capping protein subunit alpha-2 OS=Homo sapiens OX=9606 GN=CAPZA2 PE=1 SV=3,0,189.175,70,15,577,12,286,32.9,5.85,282815,4.23,13,3,cell organization and biogenesis;cellular component movement;coagulation;defense response;regulation of biological process;response to stimulus;transport,cytoskeleton;cytosol;extracellular;membrane,protein binding,Pf01267,830,ENSG00000198898.13,CAPZA2,7,Endocytosis,,COPI-independent Golgi-to-ER retrograde traffic; Advanced glycosylation endproduct receptor signaling; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR); Factors involved in megakaryocyte development and platelet production,22,High,1
Q7L576,Cytoplasmic FMR1-interacting protein 1 OS=Homo sapiens OX=9606 GN=CYFIP1 PE=1 SV=1,0,189.116,28,30,217,16,1253,145.1,6.9,98053,1.77,30,1,cell differentiation;cell growth;cell organization and biogenesis;development;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;organelle lumen,protein binding;RNA binding,"Pf05994, Pf07159",23191,ENSG00000273749.4,CYFIP1,15,Regulation of actin cytoskeleton; RNA transport,Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; G13 Signaling Pathway,Regulation of actin dynamics for phagocytic cup formation; VEGFA-VEGFR2 Pathway; Neutrophil degranulation; RHO GTPases Activate WASPs and WAVEs,16,High,1
O00192,Armadillo repeat protein deleted in velo-cardio-facial syndrome OS=Homo sapiens OX=9606 GN=ARVCF PE=1 SV=1,0,189.062,32,22,168,22,962,104.6,6.81,89964,0,22,1,development,cytoplasm;membrane;nucleus,protein binding,"Pf00514, Pf13646",421,ENSG00000099889.13,ARVCF,22,,,,0,High,1
Q32MK0,Myosin light chain kinase 3 OS=Homo sapiens OX=9606 GN=MYLK3 PE=1 SV=3,0,188.823,43,21,209,10,819,88.3,6.11,83775,144.93,11,14,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol,catalytic activity;nucleotide binding,"Pf00069, Pf07714",91807,ENSG00000140795.12,MYLK3,16,Calcium signaling pathway; cGMP-PKG signaling pathway; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Vascular smooth muscle contraction; Platelet activation; Gastric acid secretion; Focal adhesion,MicroRNAs in cardiomyocyte hypertrophy; Cardiac Progenitor Differentiation,,10,High,1
P42224,Signal transducer and activator of transcription 1-alpha/beta OS=Homo sapiens OX=9606 GN=STAT1 PE=1 SV=2,0,188.811,40,24,153,24,750,87.3,6.05,72715,,24,,cell death;cell differentiation;cell proliferation;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,DNA binding;protein binding;signal transducer activity,"Pf00017, Pf01017, Pf02864, Pf02865, Pf12162, Pf13204",6772,ENSG00000115415.18,STAT1,2,Tuberculosis; Leishmaniasis; NOD-like receptor signaling pathway; Chemokine signaling pathway; Measles; Thyroid hormone signaling pathway; Pancreatic cancer; Th1 and Th2 cell differentiation; Herpes simplex infection; Toxoplasmosis; Osteoclast differentiation; Influenza A; AGE-RAGE signaling pathway in diabetic complications; Inflammatory bowel disease (IBD); Hepatitis C; Pathways in cancer; Toll-like receptor signaling pathway; Prolactin signaling pathway; Jak-STAT signaling pathway; Hepatitis B,IL-5 Signaling Pathway; Regulation of toll-like receptor signaling pathway; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; Human Thyroid Stimulating Hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin Signaling Pathway; IL-7 Signaling Pathway; Type III interferon signaling; IL-9 Signaling Pathway; AGE/RAGE pathway; Allograft Rejection; Interleukin-11 Signaling Pathway; Adipogenesis; Oncostatin M Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Endoderm Differentiation; Kit receptor signaling pathway; IL-6 signaling pathway; VEGFA-VEGFR2 Signaling Pathway; Chemokine signaling pathway; IL-4 Signaling Pathway; p38 MAPK Signaling Pathway; EGF/EGFR Signaling Pathway; Endochondral Ossification; IL-2 Signaling Pathway; TGF-beta Receptor Signaling; EPO Receptor Signaling; Interferon type I signaling pathways; Type II interferon signaling (IFNG); Toll-like receptor signaling pathway,Regulation of RUNX2 expression and activity; ISG15 antiviral mechanism; Interleukin-35 Signalling; Downstream signal transduction; Regulation of IFNA signaling; Regulation of IFNG signaling; Signaling by cytosolic FGFR1 fusion mutants; Signaling by SCF-KIT; Interleukin-6 family signaling; Interleukin-4 and 13 signaling; Growth hormone receptor signaling,81,High,1
Q15393,Splicing factor 3B subunit 3 OS=Homo sapiens OX=9606 GN=SF3B3 PE=1 SV=4,0,188.561,31,28,157,28,1217,135.5,5.26,69461,0,28,1,cell organization and biogenesis;metabolic process;regulation of biological process,nucleus;spliceosomal complex,protein binding;RNA binding,"Pf03178, Pf10433",23450,ENSG00000189091.12,SF3B3,16,Spliceosome,mRNA Processing,mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway,7,High,1
O95182,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 OS=Homo sapiens OX=9606 GN=NDUFA7 PE=1 SV=3,0,188.541,70,19,1779,19,113,12.5,10.18,896090,36,18,6,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion;ribosome,catalytic activity;structural molecule activity,Pf07347,4701,ENSG00000267855.5; ENSG00000167774.2,NDUFA7,19,Oxidative phosphorylation; Parkinson's disease; Non-alcoholic fatty liver disease (NAFLD); Alzheimer's disease; Huntington's disease; Metabolic pathways,Electron Transport Chain; Oxidative phosphorylation,Complex I biogenesis,13,High,1
O95479,GDH/6PGL endoplasmic bifunctional protein OS=Homo sapiens OX=9606 GN=H6PD PE=1 SV=2,0,188.175,42,26,233,26,791,88.8,7.3,103744,0,26,2,metabolic process,endoplasmic reticulum;organelle lumen,catalytic activity;nucleotide binding,"Pf00479, Pf01182, Pf02781",9563,ENSG00000049239.12,H6PD,1,Carbon metabolism; Metabolic pathways; Pentose phosphate pathway,,,3,High,1
P53675,Clathrin heavy chain 2 OS=Homo sapiens OX=9606 GN=CLTCL1 PE=1 SV=2,0,188.114,11,22,619,1,1640,186.9,5.85,294362,8.24,21,4,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytosol;endosome;membrane,protein binding;signal transducer activity;structural molecule activity,"Pf00637, Pf01394, Pf04053, Pf09268, Pf13838",8218,ENSG00000070371.15,CLTCL1,22,Endocrine and other factor-regulated calcium reabsorption; Synaptic vesicle cycle; Endocytosis; Bacterial invasion of epithelial cells; Huntington's disease; Lysosome,Synaptic Vesicle Pathway,EPH-ephrin mediated repulsion of cells; Cargo recognition for clathrin-mediated endocytosis; Formation of annular gap junctions,19,High,1
O75880,"Protein SCO1 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=SCO1 PE=1 SV=1",0,187.916,36,19,905,19,301,33.8,8.88,434423,6.25,19,2,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;transport,membrane;mitochondrion,antioxidant activity;catalytic activity;metal ion binding;protein binding,"Pf00578, Pf02630, Pf13905",6341,ENSG00000133028.10,SCO1,17,,Electron Transport Chain; Copper homeostasis,TP53 Regulates Metabolic Genes; Respiratory electron transport,11,High,1
Q9H6R3,"Acyl-CoA synthetase short-chain family member 3, mitochondrial OS=Homo sapiens OX=9606 GN=ACSS3 PE=1 SV=1",0,187.864,34,20,278,20,686,74.7,8.63,128051,0,20,2,metabolic process,mitochondrion;organelle lumen,catalytic activity;nucleotide binding,"Pf00501, Pf13193",79611,ENSG00000111058.7,ACSS3,12,Propanoate metabolism; Metabolic pathways,,Synthesis of Ketone Bodies,6,High,1
P04217,Alpha-1B-glycoprotein OS=Homo sapiens OX=9606 GN=A1BG PE=1 SV=4,0,187.536,49,15,446,15,495,54.2,5.86,214977,16.71,13,5,transport,extracellular;organelle lumen,protein binding,"Pf00047, Pf13895, Pf13927",1,ENSG00000121410.11,A1BG,19,,,Platelet degranulation ; Neutrophil degranulation,7,High,1
Q6PCB7,Long-chain fatty acid transport protein 1 OS=Homo sapiens OX=9606 GN=SLC27A1 PE=1 SV=1,0,187.361,37,21,360,20,646,71.1,8.53,174633,7.12,21,3,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;membrane,catalytic activity;nucleotide binding;protein binding;transporter activity,"Pf00501, Pf13193",376497,ENSG00000130304.16,SLC27A1,19,Insulin resistance; PPAR signaling pathway,PPAR Alpha Pathway; PPAR signaling pathway,Transport of fatty acids; PPARA activates gene expression,12,High,1
P16671,Platelet glycoprotein 4 OS=Homo sapiens OX=9606 GN=CD36 PE=1 SV=2,0,187.305,25,17,737,16,472,53,7.96,365601,11.45,17,1,cell organization and biogenesis;cellular homeostasis;coagulation;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;Golgi;membrane,protein binding;receptor activity;signal transducer activity,Pf01130,948,ENSG00000135218.17,CD36,7,Hematopoietic cell lineage; ECM-receptor interaction; Phagosome; Fat digestion and absorption; Insulin resistance; Malaria; Adipocytokine signaling pathway; AMPK signaling pathway; PPAR signaling pathway,Aryl Hydrocarbon Receptor; PPAR signaling pathway; Vitamin A and Carotenoid Metabolism,MyD88:Mal cascade initiated on plasma membrane; Transcriptional regulation of white adipocyte differentiation; IRAK4 deficiency (TLR2/4); Cross-presentation of particulate exogenous antigens (phagosomes); ER-Phagosome pathway; PPARA activates gene expression; Activated TLR4 signalling; Platelet degranulation ; Scavenging by Class B Receptors; Neutrophil degranulation; Regulation of TLR by endogenous ligand; Interleukin-4 and 13 signaling; MyD88 deficiency (TLR2/4),49,High,1
A6NMZ7,Collagen alpha-6(VI) chain OS=Homo sapiens OX=9606 GN=COL6A6 PE=1 SV=2,0,187.249,18,31,218,31,2263,247,6.89,89543,8.14,29,3,metabolic process,extracellular,,"Pf00092, Pf01391, Pf13519",131873,ENSG00000206384.10,COL6A6,3,Protein digestion and absorption; PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction,,ECM proteoglycans; Collagen degradation; Integrin cell surface interactions; Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization; NCAM1 interactions; Signaling by PDGF,20,High,1
P26599,Polypyrimidine tract-binding protein 1 OS=Homo sapiens OX=9606 GN=PTBP1 PE=1 SV=1,0,187.067,50,15,327,13,531,57.2,9.17,148401,1.76,15,2,metabolic process;regulation of biological process;response to stimulus,membrane;nucleus,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",5725,ENSG00000011304.19,PTBP1,19,,mir-124 predicted interactions with cell cycle and differentiation; mRNA Processing,mRNA Splicing - Major Pathway; FGFR2 alternative splicing,11,High,1
Q06830,Peroxiredoxin-1 OS=Homo sapiens OX=9606 GN=PRDX1 PE=1 SV=1,0,186.93,59,20,1227,15,199,22.1,8.13,657455,0,20,2,cell proliferation;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;mitochondrion;nucleus,antioxidant activity;catalytic activity;protein binding;RNA binding,"Pf00578, Pf08534, Pf10417",5052,ENSG00000117450.13,PRDX1,1,Peroxisome,Androgen receptor signaling pathway; Selenium Micronutrient Network; NRF2 pathway,TP53 Regulates Metabolic Genes; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Detoxification of Reactive Oxygen Species,15,High,1
Q06124,Tyrosine-protein phosphatase non-receptor type 11 OS=Homo sapiens OX=9606 GN=PTPN11 PE=1 SV=2,0,186.903,46,22,355,22,597,68.4,7.3,148884,,22,,cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;mitochondrion;nucleus,catalytic activity;protein binding,"Pf00017, Pf00102, Pf00782",5781,ENSG00000179295.17,PTPN11,12,Epithelial cell signaling in Helicobacter pylori infection; Chronic myeloid leukemia; Proteoglycans in cancer; Axon guidance; Neurotrophin signaling pathway; Leukocyte transendothelial migration; Insulin resistance; Natural killer cell mediated cytotoxicity; Herpes simplex infection; Adipocytokine signaling pathway; Renal cell carcinoma; Ras signaling pathway; Phospholipase D signaling pathway; Jak-STAT signaling pathway,IL-5 Signaling Pathway; Heart Development; IL-1 signaling pathway; Leptin signaling pathway; Prolactin Signaling Pathway; B Cell Receptor Signaling Pathway; Interleukin-11 Signaling Pathway; Oncostatin M Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Alpha 6 Beta 4 signaling pathway; IL-3 Signaling Pathway; Kit receptor signaling pathway; Signaling of Hepatocyte Growth Factor Receptor; Rac1/Pak1/p38/MMP-2 pathway; IL-6 signaling pathway; Hepatitis C and Hepatocellular Carcinoma; VEGFA-VEGFR2 Signaling Pathway; ESC Pluripotency Pathways; IL-4 Signaling Pathway; EGF/EGFR Signaling Pathway; Insulin Signaling; IL-2 Signaling Pathway; Interferon type I signaling pathways; Type II interferon signaling (IFNG); T-Cell antigen Receptor (TCR)  Signaling Pathway,"PI3K Cascade; PD-1 signaling; Tie2 Signaling; PECAM1 interactions; PI-3K cascade:FGFR3; FRS-mediated FGFR4 signaling; Signaling by Leptin; Signal regulatory protein family interactions; CTLA4 inhibitory signaling; Downstream signal transduction; Activated TLR4 signalling; Platelet sensitization by LDL; MET activates PTPN11; PI-3K cascade:FGFR4; Constitutive Signaling by Aberrant PI3K in Cancer; Interleukin-6 family signaling; MAPK1 (ERK2) activation; Interleukin-20 family signaling; Spry regulation of FGF signaling; Netrin mediated repulsion signals; Interleukin-3, 5 and GM-CSF signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; MAPK3 (ERK1) activation; Prolactin receptor signaling; Regulation of IFNA signaling; FRS-mediated FGFR3 signaling; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; FRS-mediated FGFR2 signaling; GPVI-mediated activation cascade; FRS-mediated FGFR1 signaling; Regulation of IFNG signaling; PI-3K cascade:FGFR2; RET signaling; Signaling by SCF-KIT; Regulation of RUNX1 Expression and Activity; GAB1 signalosome; PI-3K cascade:FGFR1",134,High,1
P00390,"Glutathione reductase, mitochondrial OS=Homo sapiens OX=9606 GN=GSR PE=1 SV=2",0,186.701,57,17,463,17,522,56.2,8.5,217342,17.05,15,7,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;mitochondrion;organelle lumen,antioxidant activity;catalytic activity;nucleotide binding,"Pf00070, Pf02852, Pf07992, Pf13738",2936,ENSG00000104687.12,GSR,8,Thyroid hormone synthesis; Glutathione metabolism,Glutathione metabolism; Selenium Micronutrient Network; NRF2 pathway; Amino Acid metabolism; One carbon metabolism and related pathways; Oxidative Stress; Sulfation Biotransformation Reaction; Metapathway biotransformation,Detoxification of Reactive Oxygen Species,13,High,1
O43776,"Asparagine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=NARS1 PE=1 SV=1",0,186.612,42,21,289,21,548,62.9,6.25,126849,1.76,21,2,metabolic process,cytoplasm;cytosol;mitochondrion,catalytic activity;nucleotide binding,"Pf00152, Pf01336",4677,ENSG00000134440.11,NARS,18,Aminoacyl-tRNA biosynthesis,Photodynamic therapy-induced unfolded protein response,Cytosolic tRNA aminoacylation,6,High,1
Q9Y6G9,Cytoplasmic dynein 1 light intermediate chain 1 OS=Homo sapiens OX=9606 GN=DYNC1LI1 PE=1 SV=3,0,186.594,51,22,328,22,523,56.5,6.42,157039,0,22,1,cell division;cell organization and biogenesis;cellular component movement;regulation of biological process;transport,chromosome;cytoplasm;cytoskeleton;cytosol;membrane,catalytic activity;motor activity;nucleotide binding;protein binding;RNA binding,"Pf00005, Pf05783",51143,ENSG00000144635.8,DYNC1LI1,3,Vasopressin-regulated water reabsorption; Phagosome; Salmonella infection,,COPI-independent Golgi-to-ER retrograde traffic; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Neutrophil degranulation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR),38,High,1
P01834,Immunoglobulin kappa constant OS=Homo sapiens OX=9606 GN=IGKC PE=1 SV=2,0,186.533,80,17,1093,17,107,11.8,6.52,558714,181.67,16,3,cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity;protein binding,Pf07654,3514,,IGKC,2,,,FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis,26,High,1
Q6UVK1,Chondroitin sulfate proteoglycan 4 OS=Homo sapiens OX=9606 GN=CSPG4 PE=1 SV=2,0,186.343,21,36,156,36,2322,250.4,5.47,64143,,36,,cell differentiation;cell proliferation;cellular component movement;development;metabolic process;regulation of biological process;response to stimulus,cell surface;extracellular;membrane;organelle lumen,protein binding;signal transducer activity,"Pf00054, Pf02210",1464,ENSG00000173546.7,CSPG4,15,,Spinal Cord Injury,"A tetrasaccharide linker sequence is required for GAG synthesis; Dermatan sulfate biosynthesis; Defective CHSY1 causes TPBS; Defective B4GALT7 causes EDS, progeroid type; Defective B3GALT6 causes EDSP2 and SEMDJL1; CS/DS degradation; Defective CHST14 causes EDS, musculocontractural type; Defective CHST3 causes SEDCJD; Chondroitin sulfate biosynthesis; Defective B3GAT3 causes JDSSDHD",19,High,1
O60506,Heterogeneous nuclear ribonucleoprotein Q OS=Homo sapiens OX=9606 GN=SYNCRIP PE=1 SV=2,0,186.124,42,20,347,16,623,69.6,8.59,162106,0,19,3,cell differentiation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;endoplasmic reticulum;membrane;nucleus;spliceosomal complex,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",10492,ENSG00000135316.17,SYNCRIP,6,,,,0,High,1
Q8NBN7,Retinol dehydrogenase 13 OS=Homo sapiens OX=9606 GN=RDH13 PE=1 SV=2,0,186.122,58,19,366,19,331,35.9,8.1,180105,1.6,19,1,metabolic process;response to stimulus,membrane;mitochondrion,catalytic activity,"Pf00106, Pf03435, Pf08659",112724,ENSG00000160439.15; ENSG00000276684.4,RDH13,19; CHR_HSCHR19_4_CTG3_1,,,RA biosynthesis pathway,4,High,1
Q9UHD9,Ubiquilin-2 OS=Homo sapiens OX=9606 GN=UBQLN2 PE=1 SV=2,0,186.115,33,15,178,8,624,65.7,5.22,88350,0,15,1,metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;nucleus;vacuole,protein binding,"Pf00240, Pf00627, Pf11976",29978,ENSG00000188021.8,UBQLN2,X,Protein processing in endoplasmic reticulum,,Cargo recognition for clathrin-mediated endocytosis,5,High,1
P61019,Ras-related protein Rab-2A OS=Homo sapiens OX=9606 GN=RAB2A PE=1 SV=1,0,186.09,66,14,431,7,212,23.5,6.54,219610,1.67,14,3,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;endoplasmic reticulum;Golgi;membrane;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00009, Pf00025, Pf00071, Pf01926, Pf04670, Pf08477",5862,ENSG00000104388.14,RAB2A,8,AMPK signaling pathway,Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,Golgi Cisternae Pericentriolar Stack Reorganization; RAB geranylgeranylation,10,High,1
Q5SSJ5,Heterochromatin protein 1-binding protein 3 OS=Homo sapiens OX=9606 GN=HP1BP3 PE=1 SV=1,0,185.851,38,21,430,21,553,61.2,9.67,203795,,21,,cell organization and biogenesis;regulation of biological process;response to stimulus,chromosome;nucleus,DNA binding;protein binding,Pf00538,50809,ENSG00000127483.17,HP1BP3,1,,,,0,High,1
P51991,Heterogeneous nuclear ribonucleoprotein A3 OS=Homo sapiens OX=9606 GN=HNRNPA3 PE=1 SV=2,0,185.702,34,16,391,4,378,39.6,9.01,193740,3.36,16,2,metabolic process;transport,cytoplasm;nucleus;spliceosomal complex,protein binding;RNA binding;transporter activity,"Pf00076, Pf13893, Pf14259",220988,ENSG00000170144.20,HNRNPA3,2,Spliceosome,,mRNA Splicing - Major Pathway,5,High,1
O60664,Perilipin-3 OS=Homo sapiens OX=9606 GN=PLIN3 PE=1 SV=3,0,185.634,47,15,223,15,434,47,5.44,109263,0,15,1,transport,cytoplasm;cytosol;endosome;Golgi;membrane,protein binding,Pf03036,10226,ENSG00000105355.8,PLIN3,19,,,Triglyceride catabolism; Retrograde transport at the Trans-Golgi-Network,8,High,1
P54289-2,Isoform 2 of Voltage-dependent calcium channel subunit alpha-2/delta-1 OS=Homo sapiens OX=9606 GN=CACNA2D1,0,185.625,30,25,235,1,1091,123.1,5.25,107347,2.5,23,3,cellular homeostasis;regulation of biological process;transport,endoplasmic reticulum;membrane,metal ion binding;transporter activity,"Pf00092, Pf02743, Pf08399, Pf08473, Pf13519, Pf13768",781,ENSG00000153956.15,CACNA2D1,7,Arrhythmogenic right ventricular cardiomyopathy (ARVC); Cardiac muscle contraction; Dilated cardiomyopathy; Hypertrophic cardiomyopathy (HCM); MAPK signaling pathway; Oxytocin signaling pathway; Adrenergic signaling in cardiomyocytes,Arrhythmogenic Right Ventricular Cardiomyopathy,,8,High,1
Q7Z434,Mitochondrial antiviral-signaling protein OS=Homo sapiens OX=9606 GN=MAVS PE=1 SV=2,0,185.496,58,17,220,17,540,56.5,5.52,122431,4.06,16,2,cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,membrane;mitochondrion,protein binding;signal transducer activity;transporter activity,,57506,ENSG00000088888.17,MAVS,20,Hepatitis B; Herpes simplex infection; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; NOD-like receptor signaling pathway; Influenza A; Hepatitis C; Measles,RIG-I-like Receptor Signaling,Ovarian tumor domain proteases; TRAF3-dependent IRF activation pathway; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Negative regulators of DDX58/IFIH1 signaling; TRAF6 mediated NF-kB activation; TRAF6 mediated IRF7 activation,21,High,1
O95782,AP-2 complex subunit alpha-1 OS=Homo sapiens OX=9606 GN=AP2A1 PE=1 SV=3,0,185.17,33,25,440,20,977,107.5,7.03,203878,0,25,2,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;membrane,protein binding;transporter activity,"Pf01602, Pf02296, Pf02883, Pf13646",160,ENSG00000196961.12,AP2A1,19,Synaptic vesicle cycle; Huntington's disease; Endocrine and other factor-regulated calcium reabsorption; Endocytosis,Synaptic Vesicle Pathway; EGF/EGFR Signaling Pathway,"Cargo recognition for clathrin-mediated endocytosis; Nef Mediated CD8 Down-regulation; Nef Mediated CD4 Down-regulation; Trafficking of GluR2-containing AMPA receptors; Recycling pathway of L1; LDL clearance; EPH-ephrin mediated repulsion of cells; Retrograde neurotrophin signalling; VLDLR internalisation and degradation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; MHC class II antigen presentation; WNT5A-dependent internalization of FZD4",48,High,1
Q16775,"Hydroxyacylglutathione hydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=HAGH PE=1 SV=2",0,185.129,44,11,625,11,308,33.8,8.12,294295,0,11,2,metabolic process,cytoplasm;cytosol;mitochondrion;organelle lumen,catalytic activity;metal ion binding;protein binding,Pf00753,3029,ENSG00000063854.12,HAGH,16,Pyruvate metabolism,,,1,High,1
Q8WWV3,"Reticulon-4-interacting protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=RTN4IP1 PE=1 SV=2",0,185.097,54,17,344,17,396,43.6,9.11,158017,22.66,17,3,metabolic process;regulation of biological process,membrane;mitochondrion,catalytic activity;metal ion binding,"Pf00107, Pf08240, Pf13602",84816,ENSG00000130347.12,RTN4IP1,6,,,,0,High,1
P62807,Histone H2B type 1-C/E/F/G/I OS=Homo sapiens OX=9606 GN=H2BC4 PE=1 SV=4,0,184.838,68,19,1701,19,126,13.9,10.32,866066,43.18,19,5,cell organization and biogenesis;defense response;metabolic process;response to stimulus,chromosome;cytosol;nucleus,DNA binding;protein binding,"Pf00125, Pf00808",8346; 3017; 8347; 8343; 8339; 8344,ENSG00000274290.2; ENSG00000180596.7; ENSG00000277224.2; ENSG00000278588.1; ENSG00000273802.2,HIST1H2BI; HIST1H2BD; HIST1H2BC; HIST1H2BF; HIST1H2BG; HIST1H2BE,6,Viral carcinogenesis; Alcoholism; Systemic lupus erythematosus,,SIRT1 negatively regulates rRNA expression; Nonhomologous End-Joining (NHEJ); Activation of anterior HOX genes in hindbrain development during early embryogenesis; NoRC negatively regulates rRNA expression; Meiotic synapsis; Transcriptional regulation by small RNAs; Meiotic recombination; PRC2 methylates histones and DNA; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; HDACs deacetylate histones; Formation of the beta-catenin:TCF transactivating complex; DNA methylation; G2/M DNA damage checkpoint; Packaging Of Telomere Ends; Ub-specific processing proteases; Amyloid fiber formation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RNA Polymerase I Chain Elongation; HATs acetylate histones; Deposition of new CENPA-containing nucleosomes at the centromere; E3 ubiquitin ligases ubiquitinate target proteins; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Condensation of Prophase Chromosomes; Processing of DNA double-strand break ends; DNA Damage/Telomere Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); B-WICH complex positively regulates rRNA expression; RNA Polymerase I Promoter Opening; Oxidative Stress Induced Senescence,77,High,1
O43143,Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 OS=Homo sapiens OX=9606 GN=DHX15 PE=1 SV=2,0,184.718,33,26,250,26,795,90.9,7.46,102793,,26,,metabolic process;response to stimulus,cytoplasm;nucleus;spliceosomal complex,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00270, Pf00271, Pf04408, Pf07717, Pf13401",1665,ENSG00000109606.12,DHX15,4,Spliceosome,mRNA Processing,mRNA Splicing - Major Pathway,6,High,1
P24844,Myosin regulatory light polypeptide 9 OS=Homo sapiens OX=9606 GN=MYL9 PE=1 SV=4,0,184.695,57,14,638,4,172,19.8,4.92,305614,0,14,2,regulation of biological process,cytosol,metal ion binding;structural molecule activity,"Pf00036, Pf13202, Pf13405, Pf13833",10398,ENSG00000101335.9,MYL9,20,cAMP signaling pathway; Oxytocin signaling pathway; Regulation of actin cytoskeleton; Vascular smooth muscle contraction; Leukocyte transendothelial migration; Focal adhesion; cGMP-PKG signaling pathway; Tight junction,Striated Muscle Contraction,RHO GTPases activate PAKs; EPHA-mediated growth cone collapse; RHO GTPases Activate ROCKs; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate CIT; RHO GTPases activate PKNs,30,High,1
P10768,S-formylglutathione hydrolase OS=Homo sapiens OX=9606 GN=ESD PE=1 SV=2,0,184.534,52,13,892,13,282,31.4,7.02,428090,31.41,11,2,metabolic process,cytoplasm;organelle lumen,catalytic activity;protein binding,"Pf00326, Pf00756, Pf05448, Pf12695, Pf12697",2098,ENSG00000139684.13,ESD,13,Carbon metabolism,"Phase I biotransformations, non P450",Glutathione conjugation,6,High,1
Q9Y281,Cofilin-2 OS=Homo sapiens OX=9606 GN=CFL2 PE=1 SV=1,0,184.233,66,17,662,8,166,18.7,7.88,345253,1.7,17,2,cell organization and biogenesis;cellular homeostasis;regulation of biological process,cytoplasm;cytoskeleton;nucleus,protein binding,Pf00241,1073,ENSG00000165410.14,CFL2,14,Axon guidance; Pertussis; Regulation of actin cytoskeleton; Fc gamma R-mediated phagocytosis,Leptin signaling pathway; Regulation of Microtubule Cytoskeleton; Regulation of Actin Cytoskeleton; G13 Signaling Pathway,,8,High,1
Q9H0U4,Ras-related protein Rab-1B OS=Homo sapiens OX=9606 GN=RAB1B PE=1 SV=1,0,184.198,66,15,669,6,201,22.2,5.73,333736,3.9,15,4,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;Golgi;membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf01926, Pf04670, Pf08477, Pf09439",81876,ENSG00000174903.15,RAB1B,11,Legionellosis,,COPI-dependent Golgi-to-ER retrograde traffic; COPII (Coat Protein 2) Mediated Vesicle Transport; COPI-mediated anterograde transport; Golgi Cisternae Pericentriolar Stack Reorganization; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation,21,High,1
P35611,Alpha-adducin OS=Homo sapiens OX=9606 GN=ADD1 PE=1 SV=2,0,184.146,39,21,257,20,737,80.9,5.83,119475,6.28,20,2,cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,protein binding;RNA binding;structural molecule activity,Pf00596,118,ENSG00000087274.16,ADD1,4,,,XBP1(S) activates chaperone genes; Caspase-mediated cleavage of cytoskeletal proteins; Miscellaneous transport and binding events,11,High,1
Q13177,Serine/threonine-protein kinase PAK 2 OS=Homo sapiens OX=9606 GN=PAK2 PE=1 SV=3,0,184.04,59,24,215,24,524,58,5.96,93321,,24,,cell death;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding,"Pf00069, Pf00786, Pf07714, Pf14531",5062,ENSG00000180370.10,PAK2,3,Axon guidance; Renal cell carcinoma; Regulation of actin cytoskeleton; MAPK signaling pathway; Ras signaling pathway; Focal adhesion; ErbB signaling pathway; T cell receptor signaling pathway,Integrin-mediated Cell Adhesion; Apoptosis-related network due to altered Notch3 in ovarian cancer; Focal Adhesion; Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation; TGF-beta Signaling Pathway; MAPK Signaling Pathway; VEGFA-VEGFR2 Signaling Pathway; Regulation of Actin Cytoskeleton,Sema3A PAK dependent Axon repulsion; Smooth Muscle Contraction; FCERI mediated MAPK activation; Nef and signal transduction; Ephrin signaling; Generation of second messenger molecules; Regulation of PAK-2p34 activity by PS-GAP/RHG10; Interleukin-12 family signaling; RHO GTPases activate PAKs; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Stimulation of the cell death response by PAK-2p34; Regulation of activated PAK-2p34 by proteasome mediated degradation; CD209 (DC-SIGN) signaling; Activation of RAC1; CD28 dependent Vav1 pathway; VEGFR2 mediated vascular permeability; MAPK6/MAPK4 signaling,65,High,1
P54578,Ubiquitin carboxyl-terminal hydrolase 14 OS=Homo sapiens OX=9606 GN=USP14 PE=1 SV=3,0,183.805,52,20,347,20,494,56,5.3,163400,3.08,19,2,cell communication;metabolic process;regulation of biological process,cell surface;cytoplasm;cytosol;membrane;nucleus;proteasome,catalytic activity;enzyme regulator activity;protein binding,"Pf00443, Pf13423",9097,ENSG00000101557.14,USP14,18,,,Ub-specific processing proteases,4,High,1
Q7Z7B0,Filamin-A-interacting protein 1 OS=Homo sapiens OX=9606 GN=FILIP1 PE=1 SV=1,0,183.673,32,29,190,29,1213,138,8.32,78928,55.25,23,9,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;Golgi;membrane,catalytic activity;motor activity,"Pf01576, Pf02463, Pf04111, Pf04156, Pf04849, Pf05109, Pf05483, Pf05557, Pf05701, Pf06156, Pf06160, Pf07888, Pf08317, Pf09325, Pf09727, Pf09730, Pf09787, Pf12128, Pf13166",27145,ENSG00000118407.14,FILIP1,6,,,,0,High,1
P46379,Large proline-rich protein BAG6 OS=Homo sapiens OX=9606 GN=BAG6 PE=1 SV=2,0,183.649,29,24,186,24,1132,119.3,5.6,82074,3.42,24,1,cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;membrane;nucleus,protein binding,"Pf00240, Pf11976, Pf12057, Pf13881",7917,ENSG00000204463.12; ENSG00000096155.15; ENSG00000229524.10; ENSG00000233348.10,BAG6,6; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1,,,,0,High,1
Q9Y2A7,Nck-associated protein 1 OS=Homo sapiens OX=9606 GN=NCKAP1 PE=1 SV=1,0,183.602,33,29,201,29,1128,128.7,6.62,79706,5.05,28,2,cell death;cell organization and biogenesis;regulation of biological process;response to stimulus,cytosol;membrane,protein binding,Pf09735,10787,ENSG00000061676.14,NCKAP1,2,Regulation of actin cytoskeleton,Exercise-induced Circadian Regulation; Regulation of Actin Cytoskeleton,Regulation of actin dynamics for phagocytic cup formation; VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs,14,High,1
P18859,"ATP synthase-coupling factor 6, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5PF PE=1 SV=1",0,183.563,76,16,639,16,108,12.6,9.52,300382,2.2,16,2,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion,catalytic activity;transporter activity,Pf05511,522,ENSG00000154723.12,ATP5J,21,Alzheimer's disease; Oxidative phosphorylation; Huntington's disease; Metabolic pathways; Parkinson's disease,Electron Transport Chain; Oxidative phosphorylation,Cristae formation; Formation of ATP by chemiosmotic coupling,14,High,1
Q92900,Regulator of nonsense transcripts 1 OS=Homo sapiens OX=9606 GN=UPF1 PE=1 SV=2,0,183.496,34,30,199,30,1129,124.3,6.61,84881,0,30,1,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,chromosome;cytoplasm;cytosol;nucleus;spliceosomal complex,catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding,"Pf04851, Pf09416, Pf13086, Pf13087, Pf13245, Pf13604",5976,ENSG00000005007.12,UPF1,19,mRNA surveillance pathway; RNA transport,,Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC),6,High,1
P50895,Basal cell adhesion molecule OS=Homo sapiens OX=9606 GN=BCAM PE=1 SV=2,0,183.272,40,16,251,16,628,67.4,5.81,123208,3.66,15,3,regulation of biological process;response to stimulus,cell surface;extracellular;membrane,protein binding;receptor activity;signal transducer activity,"Pf00047, Pf07679, Pf08205, Pf13895, Pf13927",4059,ENSG00000187244.10,BCAM,19,,,,0,High,1
P22059,Oxysterol-binding protein 1 OS=Homo sapiens OX=9606 GN=OSBP PE=1 SV=1,0,183.247,38,24,198,24,807,89.4,7.3,88277,0,24,1,metabolic process;regulation of biological process;transport,cytoplasm;cytosol;endoplasmic reticulum;Golgi;membrane;nucleus,protein binding;transporter activity,"Pf00169, Pf01237, Pf15406, Pf15409, Pf15413",5007,ENSG00000110048.11,OSBP,11,,,Synthesis of bile acids and bile salts; Sphingolipid de novo biosynthesis,7,High,1
O95834,Echinoderm microtubule-associated protein-like 2 OS=Homo sapiens OX=9606 GN=EML2 PE=1 SV=1,0,183.24,39,18,266,17,649,70.6,6.32,123891,,18,,regulation of biological process,cytoplasm;cytoskeleton,protein binding,"Pf00400, Pf03451",24139,ENSG00000125746.16,EML2,19,,,,0,High,1
Q15008,26S proteasome non-ATPase regulatory subunit 6 OS=Homo sapiens OX=9606 GN=PSMD6 PE=1 SV=1,0,183.001,47,21,306,21,389,45.5,5.62,145480,0,21,1,metabolic process;regulation of biological process;response to stimulus;transport,cytosol;extracellular;organelle lumen;proteasome,catalytic activity;enzyme regulator activity;protein binding,"Pf01399, Pf10602",9861,ENSG00000163636.10,PSMD6,3,Proteasome; Epstein-Barr virus infection,Proteasome Degradation; Parkin-Ubiquitin Proteasomal System pathway,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Neutrophil degranulation; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,153,High,1
Q13045-2,Isoform 2 of Protein flightless-1 homolog OS=Homo sapiens OX=9606 GN=FLII,0,182.814,27,27,256,2,1214,138.4,6.07,115472,10.95,25,4,cell organization and biogenesis;development;metabolic process;regulation of biological process,cytosol,protein binding,"Pf00626, Pf12799, Pf13855",2314,ENSG00000177731.15; ENSG00000284571.1,FLII,17; CHR_HSCHR17_3_CTG1,,,,0,High,1
Q8IYB8,"ATP-dependent RNA helicase SUPV3L1, mitochondrial OS=Homo sapiens OX=9606 GN=SUPV3L1 PE=1 SV=1",0,182.651,33,21,356,21,786,87.9,7.99,169984,2.13,21,3,cell organization and biogenesis;metabolic process;regulation of biological process,mitochondrion;nucleus;organelle lumen,catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding,"Pf00271, Pf12513",6832,ENSG00000156502.13,SUPV3L1,10,,,,0,High,1
O14950,Myosin regulatory light chain 12B OS=Homo sapiens OX=9606 GN=MYL12B PE=1 SV=2,0,182.565,57,14,620,4,172,19.8,4.84,310565,0,14,1,regulation of biological process;response to stimulus,cytosol,metal ion binding;protein binding,"Pf00036, Pf13202, Pf13405, Pf13833",103910; 10627,ENSG00000118680.12,MYL12B; MYL12A,18,Tight junction; Leukocyte transendothelial migration; Focal adhesion; Platelet activation; Regulation of actin cytoskeleton,Human Thyroid Stimulating Hormone (TSH) signaling pathway,RHO GTPases activate PAKs; EPHA-mediated growth cone collapse; RHO GTPases Activate ROCKs; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate CIT; RHO GTPases activate PKNs,22,High,1
O43815,Striatin OS=Homo sapiens OX=9606 GN=STRN PE=1 SV=4,0,182.529,41,21,159,19,780,86.1,5.27,71210,,21,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;membrane,protein binding,"Pf00400, Pf08232",6801,ENSG00000115808.11,STRN,2,,,,0,High,1
P30837,"Aldehyde dehydrogenase X, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH1B1 PE=1 SV=3",0,182.339,48,20,349,17,517,57.2,6.8,172578,2.73,19,3,metabolic process,mitochondrion;organelle lumen,catalytic activity;nucleotide binding,Pf00171,219,,ALDH1B1,9,"beta-Alanine metabolism; Metabolic pathways; Fatty acid degradation; Pyruvate metabolism; Tryptophan metabolism; Ascorbate and aldarate metabolism; Glycerolipid metabolism; Arginine and proline metabolism; Lysine degradation; Glycolysis / Gluconeogenesis; Valine, leucine and isoleucine degradation; Histidine metabolism; Pentose and glucuronate interconversions",,Ethanol oxidation,17,High,1
Q6NUK1,Calcium-binding mitochondrial carrier protein SCaMC-1 OS=Homo sapiens OX=9606 GN=SLC25A24 PE=1 SV=2,0,182.203,51,23,406,23,477,53.3,6.33,180686,6.42,23,3,regulation of biological process;response to stimulus;transport,membrane;mitochondrion,metal ion binding;protein binding;transporter activity,"Pf00036, Pf00153, Pf10591, Pf12763, Pf13405, Pf13499, Pf13833",29957,ENSG00000085491.15; ENSG00000284468.1,SLC25A24,1; CHR_HSCHR1_6_CTG3,,,,0,High,1
O14967,Calmegin OS=Homo sapiens OX=9606 GN=CLGN PE=1 SV=1,0,182.104,51,21,245,21,610,70,4.69,110866,16.48,19,5,cell organization and biogenesis;metabolic process,endoplasmic reticulum;membrane,metal ion binding;protein binding,Pf00262,1047,ENSG00000153132.12,CLGN,4,,,,0,High,1
P17066,Heat shock 70 kDa protein 6 OS=Homo sapiens OX=9606 GN=HSPA6 PE=1 SV=2,0,181.769,21,23,629,3,643,71,6.14,307377,3.57,23,4,cell organization and biogenesis;metabolic process;response to stimulus;transport,cytoplasm;cytosol;extracellular;organelle lumen,catalytic activity;nucleotide binding;protein binding,"Pf00012, Pf06723",3310,ENSG00000173110.7,HSPA6,1,Antigen processing and presentation; Toxoplasmosis; Epstein-Barr virus infection; Estrogen signaling pathway; MAPK signaling pathway; Endocytosis; Measles; Protein processing in endoplasmic reticulum; Spliceosome; Legionellosis; Longevity regulating pathway - multiple species; Influenza A,Parkin-Ubiquitin Proteasomal System pathway,Neutrophil degranulation; Regulation of HSF1-mediated heat shock response,20,High,1
P63104,14-3-3 protein zeta/delta OS=Homo sapiens OX=9606 GN=YWHAZ PE=1 SV=1,0,181.648,58,17,1082,11,245,27.7,4.79,567195,6.76,16,4,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;mitochondrion;nucleus,catalytic activity;protein binding;RNA binding,Pf00244,7534,ENSG00000164924.17,YWHAZ,8,Pathogenic Escherichia coli infection; Cell cycle; Epstein-Barr virus infection; Viral carcinogenesis; Oocyte meiosis; Hepatitis B; PI3K-Akt signaling pathway; Hippo signaling pathway,Cell Cycle; Prolactin Signaling Pathway; Pathogenic Escherichia coli infection; Myometrial Relaxation and Contraction Pathways; Calcium Regulation in the Cardiac Cell; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Interleukin-3, 5 and GM-CSF signaling; KSRP (KHSRP) binds and destabilizes mRNA; Activation of BAD and translocation to mitochondria ; GP1b-IX-V activation signalling; Translocation of GLUT4 to the plasma membrane; Rap1 signalling; Deactivation of the beta-catenin transactivating complex; TP53 Regulates Metabolic Genes; RHO GTPases activate PKNs",51,High,1
Q15181,Inorganic pyrophosphatase OS=Homo sapiens OX=9606 GN=PPA1 PE=1 SV=2,0,181.558,58,18,264,17,289,32.6,5.86,132249,0,17,2,metabolic process,cytoplasm;cytosol,catalytic activity;metal ion binding,Pf00719,5464,ENSG00000180817.11,PPA1,10,Oxidative phosphorylation,,Cytosolic tRNA aminoacylation; Pyrophosphate hydrolysis,7,High,1
Q15436,Protein transport protein Sec23A OS=Homo sapiens OX=9606 GN=SEC23A PE=1 SV=2,0,181.557,33,19,233,16,765,86.1,7.08,117416,5.08,19,1,cell organization and biogenesis;transport,cytoplasm;cytosol;endoplasmic reticulum;membrane,metal ion binding;protein binding,"Pf00626, Pf04810, Pf04811, Pf04815, Pf08033",10484,ENSG00000100934.14,SEC23A,14,Protein processing in endoplasmic reticulum,Sterol Regulatory Element-Binding Proteins (SREBP) signalling,"Regulation of cholesterol biosynthesis by SREBP (SREBF); Cargo concentration in the ER; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; COPII (Coat Protein 2) Mediated Vesicle Transport; MHC class II antigen presentation",20,High,1
P11766,Alcohol dehydrogenase class-3 OS=Homo sapiens OX=9606 GN=ADH5 PE=1 SV=4,0,181.529,51,18,771,18,374,39.7,7.49,358974,0,18,2,metabolic process;response to stimulus,cytoplasm;cytosol;mitochondrion,catalytic activity;metal ion binding;protein binding,"Pf00107, Pf08240",128,ENSG00000197894.10,ADH5,4,Fatty acid degradation; Metabolic pathways; Drug metabolism - cytochrome P450; Carbon metabolism; Chemical carcinogenesis; Metabolism of xenobiotics by cytochrome P450; Glycolysis / Gluconeogenesis; Retinol metabolism; Tyrosine metabolism,Folate-Alcohol and Cancer Pathway; Amino Acid metabolism,Ethanol oxidation,15,High,1
P52943,Cysteine-rich protein 2 OS=Homo sapiens OX=9606 GN=CRIP2 PE=1 SV=1,0,180.669,61,18,555,17,208,22.5,8.72,274074,36.93,16,5,regulation of biological process,,metal ion binding;protein binding,Pf00412,1397,ENSG00000182809.10,CRIP2,14,,,,0,High,1
Q13617,Cullin-2 OS=Homo sapiens OX=9606 GN=CUL2 PE=1 SV=2,0,179.901,39,23,217,23,745,86.9,6.92,92056,,23,,metabolic process;regulation of biological process;response to stimulus,cytosol,catalytic activity;protein binding,"Pf00888, Pf10557",8453,ENSG00000108094.14,CUL2,10,Renal cell carcinoma; HIF-1 signaling pathway; Pathways in cancer; Ubiquitin mediated proteolysis,,Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation,20,High,1
P48637,Glutathione synthetase OS=Homo sapiens OX=9606 GN=GSS PE=1 SV=1,0,179.887,50,19,274,19,474,52.4,5.92,118672,21.48,18,2,metabolic process;response to stimulus,cytosol,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf03199, Pf03917",2937,ENSG00000100983.9,GSS,20,Glutathione metabolism; Cysteine and methionine metabolism; Metabolic pathways,Glutathione metabolism; Trans-sulfuration and one carbon metabolism; Amino Acid metabolism; One carbon metabolism and related pathways; Metapathway biotransformation,Glutathione synthesis and recycling; Defective GSS causes Glutathione synthetase deficiency (GSS deficiency),17,High,1
Q96EY1,"DnaJ homolog subfamily A member 3, mitochondrial OS=Homo sapiens OX=9606 GN=DNAJA3 PE=1 SV=2",0,179.807,37,18,365,18,480,52.5,9.26,178236,,18,,cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;mitochondrion;nucleus;organelle lumen,enzyme regulator activity;metal ion binding;nucleotide binding;protein binding,"Pf00226, Pf00684, Pf01556",9093,ENSG00000276726.4; ENSG00000103423.13,DNAJA3,16; CHR_HSCHR16_3_CTG1,Viral carcinogenesis,,,1,High,1
P17931,Galectin-3 OS=Homo sapiens OX=9606 GN=LGALS3 PE=1 SV=5,0,179.676,36,19,808,17,250,26.1,8.56,419677,0,19,2,cell differentiation;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;extracellular;membrane;nucleus;spliceosomal complex,protein binding;RNA binding,Pf00337,3958,ENSG00000131981.15,LGALS3,14,,AGE/RAGE pathway; Spinal Cord Injury,RUNX2 regulates genes involved in differentiation of myeloid cells; Advanced glycosylation endproduct receptor signaling; Neutrophil degranulation; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells,13,High,1
Q92626,Peroxidasin homolog OS=Homo sapiens OX=9606 GN=PXDN PE=1 SV=2,0,179.168,25,25,179,25,1479,165.2,7.17,81512,0,25,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;extracellular,antioxidant activity;catalytic activity;metal ion binding;protein binding;structural molecule activity,"Pf00047, Pf00093, Pf03098, Pf05825, Pf07679, Pf07686, Pf08205, Pf12799, Pf13855, Pf13895, Pf13927",7837,ENSG00000130508.10,PXDN,2,,EGF/EGFR Signaling Pathway,Crosslinking of collagen fibrils,5,High,1
Q93034,Cullin-5 OS=Homo sapiens OX=9606 GN=CUL5 PE=1 SV=4,0,179.105,36,26,289,26,780,90.9,7.94,131386,0,26,3,cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;nucleus,catalytic activity;protein binding;receptor activity;transporter activity,"Pf00888, Pf10557",8065,ENSG00000166266.13,CUL5,11,Ubiquitin mediated proteolysis,Apoptosis-related network due to altered Notch3 in ovarian cancer; Dual hijack model of Vif in HIV infection,Downregulation of ERBB2 signaling; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation,19,High,1
P63151,Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R2A PE=1 SV=1,0,179.002,39,16,231,8,447,51.7,6.2,110217,37.91,16,2,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytosol,catalytic activity;enzyme regulator activity;protein binding,,5520,ENSG00000221914.9,PPP2R2A,8,AMPK signaling pathway; Tight junction; PI3K-Akt signaling pathway; mRNA surveillance pathway; Hippo signaling pathway; Dopaminergic synapse; Hepatitis C; Sphingolipid signaling pathway; Adrenergic signaling in cardiomyocytes; Chagas disease (American trypanosomiasis),Wnt Signaling Pathway and Pluripotency; Glycogen Metabolism,Cyclin D associated events in G1; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Initiation of Nuclear Envelope Reformation; Cyclin A/B1/B2 associated events during G2/M transition,28,High,1
P05455,Lupus La protein OS=Homo sapiens OX=9606 GN=SSB PE=1 SV=2,0,177.91,47,22,257,22,408,46.8,7.12,122049,0,22,1,metabolic process;transport,cytoplasm;nucleus,protein binding;RNA binding,"Pf00076, Pf05383, Pf08777, Pf14259",6741,ENSG00000138385.15,SSB,2,Systemic lupus erythematosus,,RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination,5,High,1
Q5SV97,PGC-1 and ERR-induced regulator in muscle protein 1 OS=Homo sapiens OX=9606 GN=PERM1 PE=2 SV=4,0,177.898,38,17,197,17,790,81.3,5.58,32100,340.92,4,14,metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,,,84808,ENSG00000187642.9,C1orf170; PERM1,1,,,Transcriptional activation of mitochondrial biogenesis,3,High,1
Q12905,Interleukin enhancer-binding factor 2 OS=Homo sapiens OX=9606 GN=ILF2 PE=1 SV=2,0,177.857,48,12,312,12,390,43,5.26,152723,,12,,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;extracellular;membrane;nucleus;organelle lumen,catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding,Pf07528,3608,ENSG00000143621.16,ILF2,1,,B Cell Receptor Signaling Pathway,Neutrophil degranulation,4,High,1
P55196-3,Isoform 3 of Afadin OS=Homo sapiens OX=9606 GN=AFDN,0,177.536,25,34,143,2,1743,197.5,6.54,60956,12.6,32,3,cell communication;cell organization and biogenesis;regulation of biological process;response to stimulus,cytosol;membrane,protein binding,"Pf00498, Pf00595, Pf00788, Pf01843",4301,ENSG00000130396.20,MLLT4; AFDN,6,,VEGFA-VEGFR2 Signaling Pathway,,1,High,1
Q9Y4J8,Dystrobrevin alpha OS=Homo sapiens OX=9606 GN=DTNA PE=1 SV=2,0,177.451,31,22,355,16,743,83.8,6.89,169760,67.9,21,4,cell communication;metabolic process;regulation of biological process;response to stimulus,cytoplasm;membrane,metal ion binding;protein binding,"Pf00569, Pf02403, Pf04111, Pf05400, Pf06637, Pf09068, Pf09069, Pf10174, Pf11932, Pf13874, Pf15376",1837,ENSG00000134769.21,DTNA,18,,,,0,High,1
P69892,Hemoglobin subunit gamma-2 OS=Homo sapiens OX=9606 GN=HBG2 PE=1 SV=2,0,177.451,75,18,3891,1,147,16.1,7.2,2381924,3.47,18,3,coagulation;transport,cytosol,metal ion binding;protein binding;transporter activity,"Pf00042, Pf06133",3048,ENSG00000196565.13,HBG2,11,,,Factors involved in megakaryocyte development and platelet production,2,High,1
Q13435,Splicing factor 3B subunit 2 OS=Homo sapiens OX=9606 GN=SF3B2 PE=1 SV=2,0,177.404,39,28,176,28,895,100.2,5.67,73812,0,28,1,metabolic process,nucleus;spliceosomal complex,protein binding;RNA binding,"Pf02037, Pf04037, Pf04046",10992,ENSG00000087365.15,SF3B2,11,Spliceosome,mRNA Processing,mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway,7,High,1
P02763,Alpha-1-acid glycoprotein 1 OS=Homo sapiens OX=9606 GN=ORM1 PE=1 SV=1,0,177.363,43,15,1206,13,201,23.5,5.02,571129,7.26,14,3,defense response;regulation of biological process;response to stimulus;transport,extracellular;organelle lumen,protein binding,Pf00061,5004,,ORM1,9,,,Platelet degranulation ; Neutrophil degranulation,7,High,1
P69891,Hemoglobin subunit gamma-1 OS=Homo sapiens OX=9606 GN=HBG1 PE=1 SV=2,0,177.342,75,18,3979,1,147,16.1,7.2,2423757,3.47,18,4,coagulation;transport,cytosol,metal ion binding;transporter activity,"Pf00042, Pf06133",3047,,HBG1,11,,,Factors involved in megakaryocyte development and platelet production,2,High,1
O96008,Mitochondrial import receptor subunit TOM40 homolog OS=Homo sapiens OX=9606 GN=TOMM40 PE=1 SV=1,0,177.234,61,16,246,16,361,37.9,7.25,109016,8.1,16,2,cell communication;metabolic process;response to stimulus;transport,cytosol;membrane;mitochondrion,protein binding;transporter activity,Pf01459,10452,ENSG00000130204.12,TOMM40,19,Amyotrophic lateral sclerosis (ALS),,Mitochondrial protein import; Metabolism of proteins; Pink/Parkin Mediated Mitophagy,5,High,1
Q96K76-4,Isoform 4 of Ubiquitin carboxyl-terminal hydrolase 47 OS=Homo sapiens OX=9606 GN=USP47,0,177.004,28,33,138,33,1355,154.6,5.06,59979,0,32,1,metabolic process;regulation of biological process;response to stimulus,cytoplasm,catalytic activity;protein binding,"Pf00443, Pf13423",55031,ENSG00000170242.17,USP47,11,,,,0,High,1
Q9BS92,Protein NipSnap homolog 3B OS=Homo sapiens OX=9606 GN=NIPSNAP3B PE=2 SV=1,0,176.586,71,14,661,11,247,28.3,9.28,266086,329.52,11,6,,mitochondrion,,Pf07978,55335,ENSG00000165028.11,NIPSNAP3B,9,,,,0,High,1
O94901,SUN domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SUN1 PE=1 SV=3,0,176.352,41,23,211,23,812,90,7.08,89566,0,22,2,cell differentiation;cell organization and biogenesis;cellular component movement;response to stimulus;transport,cytoplasm;membrane;nucleus,protein binding,"Pf07738, Pf09387, Pf10174, Pf14915",23353,,SUN1,7,,,Meiotic synapsis,4,High,1
P06737,"Glycogen phosphorylase, liver form OS=Homo sapiens OX=9606 GN=PYGL PE=1 SV=4",0,176.207,33,29,673,13,847,97.1,7.17,325293,0,29,4,cell death;metabolic process;transport,cytoplasm;cytosol;extracellular;organelle lumen,catalytic activity;nucleotide binding;protein binding,Pf00343,5836,ENSG00000100504.16,PYGL,14,Insulin signaling pathway; Metabolic pathways; Glucagon signaling pathway; Insulin resistance; Starch and sucrose metabolism,TNF alpha Signaling Pathway; Glycogen Metabolism,Neutrophil degranulation; Glycogen breakdown (glycogenolysis),14,High,1
Q9BTV4,Transmembrane protein 43 OS=Homo sapiens OX=9606 GN=TMEM43 PE=1 SV=1,0,175.707,55,18,253,18,400,44.8,8.13,111640,4.27,18,2,cell organization and biogenesis,endoplasmic reticulum;Golgi;membrane;nucleus;organelle lumen,protein binding,Pf07787,79188,ENSG00000170876.7,TMEM43,3,,,,0,High,1
O75439,Mitochondrial-processing peptidase subunit beta OS=Homo sapiens OX=9606 GN=PMPCB PE=1 SV=2,0,175.636,41,18,389,17,489,54.3,6.83,168954,0,18,3,metabolic process;transport,membrane;mitochondrion;organelle lumen,catalytic activity;metal ion binding,"Pf00675, Pf05193",9512,ENSG00000105819.13,PMPCB,7,,,Processing of SMDT1; Mitochondrial protein import; Metabolism of proteins,5,High,1
P51648,Aldehyde dehydrogenase family 3 member A2 OS=Homo sapiens OX=9606 GN=ALDH3A2 PE=1 SV=1,0,175.418,38,19,427,16,485,54.8,7.88,195392,0,19,4,metabolic process,endoplasmic reticulum;membrane;mitochondrion,catalytic activity,Pf00171,224,ENSG00000072210.18,ALDH3A2,17,"Valine, leucine and isoleucine degradation; Pentose and glucuronate interconversions; Histidine metabolism; Tryptophan metabolism; Glycerolipid metabolism; Ascorbate and aldarate metabolism; beta-Alanine metabolism; Arginine and proline metabolism; Lysine degradation; Metabolic pathways; Fatty acid degradation; Glycolysis / Gluconeogenesis; Pyruvate metabolism",Tryptophan metabolism,Sphingolipid de novo biosynthesis,18,High,1
Q14247,Src substrate cortactin OS=Homo sapiens OX=9606 GN=CTTN PE=1 SV=2,0,175.393,37,20,210,20,550,61.5,5.4,97130,1.99,20,3,cell organization and biogenesis;cellular component movement;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;Golgi;membrane,protein binding,"Pf00018, Pf02218, Pf07653, Pf14604",2017,ENSG00000085733.15,CTTN,11,Proteoglycans in cancer; Shigellosis; Tight junction; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection,Pathogenic Escherichia coli infection; Hepatitis C and Hepatocellular Carcinoma,RHO GTPases activate PAKs; Clathrin-mediated endocytosis,14,High,1
P55196-1,Isoform 2 of Afadin OS=Homo sapiens OX=9606 GN=AFDN,0,175.154,24,33,141,1,1816,205.5,6.77,61745,12.6,31,2,cell communication;cell organization and biogenesis;regulation of biological process;response to stimulus,cytosol;membrane,protein binding,"Pf00498, Pf00595, Pf00788, Pf01843",4301,,MLLT4; AFDN,6,,VEGFA-VEGFR2 Signaling Pathway,,1,High,1
Q6PIU2,Neutral cholesterol ester hydrolase 1 OS=Homo sapiens OX=9606 GN=NCEH1 PE=1 SV=3,0,174.775,43,16,615,16,408,45.8,7.23,288806,0,16,1,metabolic process,endoplasmic reticulum;membrane,catalytic activity,"Pf00135, Pf07859, Pf11144",57552,,NCEH1,3,Bile secretion,,LDL clearance,5,High,1
Q92841,Probable ATP-dependent RNA helicase DDX17 OS=Homo sapiens OX=9606 GN=DDX17 PE=1 SV=2,0,174.772,41,27,282,20,729,80.2,8.27,124949,3.57,27,3,cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00270, Pf00271",10521,ENSG00000100201.20,DDX17,22,,RIG-I-like Receptor Signaling,,1,High,1
Q16585,Beta-sarcoglycan OS=Homo sapiens OX=9606 GN=SGCB PE=1 SV=1,0,174.71,45,13,369,13,318,34.8,8.62,168969,23.65,11,6,cell organization and biogenesis,cytoplasm;cytoskeleton;membrane,,Pf04790,6443,ENSG00000163069.12,SGCB,4,Hypertrophic cardiomyopathy (HCM); Arrhythmogenic right ventricular cardiomyopathy (ARVC); Viral myocarditis; Dilated cardiomyopathy,Arrhythmogenic Right Ventricular Cardiomyopathy,,5,High,1
O15144,Actin-related protein 2/3 complex subunit 2 OS=Homo sapiens OX=9606 GN=ARPC2 PE=1 SV=1,0,174.514,72,23,370,23,300,34.3,7.36,159160,0,23,3,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;endosome;membrane,protein binding;structural molecule activity,Pf04045,10109,ENSG00000163466.15,ARPC2,2,Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Regulation of actin cytoskeleton; Endocytosis; Fc gamma R-mediated phagocytosis; Salmonella infection,Pathogenic Escherichia coli infection,EPHB-mediated forward signaling; Clathrin-mediated endocytosis; RHO GTPases Activate WASPs and WAVEs; Regulation of actin dynamics for phagocytic cup formation,23,High,1
Q92734,Protein TFG OS=Homo sapiens OX=9606 GN=TFG PE=1 SV=2,0,174.311,36,15,162,15,400,43.4,5.1,77404,0,15,1,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;membrane,protein binding;signal transducer activity,"Pf00564, Pf08232",10342,ENSG00000114354.13,TFG,3,Thyroid cancer; Pathways in cancer,,COPII (Coat Protein 2) Mediated Vesicle Transport,10,High,1
O94874,E3 UFM1-protein ligase 1 OS=Homo sapiens OX=9606 GN=UFL1 PE=1 SV=2,0,174.173,36,24,215,23,794,89.5,6.79,99278,0,24,1,cell differentiation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;membrane,catalytic activity;protein binding,Pf09743,23376,ENSG00000014123.9,UFL1,6,,,Antigen processing: Ubiquitination & Proteasome degradation,4,High,1
P62333,26S proteasome regulatory subunit 10B OS=Homo sapiens OX=9606 GN=PSMC6 PE=1 SV=1,0,173.965,47,14,310,14,389,44.1,7.49,144678,0,14,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus;proteasome,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00004, Pf00910, Pf01078, Pf05496, Pf07724, Pf07726, Pf07728, Pf13191, Pf13207, Pf13401",5706,ENSG00000100519.11,PSMC6,14,Epstein-Barr virus infection; Proteasome,Proteasome Degradation; Parkin-Ubiquitin Proteasomal System pathway,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,152,High,1
Q13618,Cullin-3 OS=Homo sapiens OX=9606 GN=CUL3 PE=1 SV=2,0,173.953,41,25,170,25,768,88.9,8.48,80960,0,25,1,cell death;cell division;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;Golgi;membrane;nucleus,catalytic activity;protein binding,"Pf00888, Pf10557",8452,ENSG00000036257.12,CUL3,2,Hedgehog signaling pathway; Ubiquitin mediated proteolysis,,Hedgehog 'on' state; Regulation of RAS by GAPs; Degradation of DVL; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Interleukin-20 family signaling,22,High,1
Q16181,Septin-7 OS=Homo sapiens OX=9606 GN=SEPTIN7 PE=1 SV=2,0,173.925,35,14,220,14,437,50.6,8.63,112544,1.68,14,2,cell differentiation;cell division;cell organization and biogenesis;regulation of biological process,chromosome;cytoplasm;cytoskeleton;cytosol;membrane;nucleus,nucleotide binding;protein binding;structural molecule activity,"Pf00735, Pf01926, Pf10211",989,,SEPT7,7,,,MAPK6/MAPK4 signaling,3,High,1
Q93100-3,Isoform 3 of Phosphorylase b kinase regulatory subunit beta OS=Homo sapiens OX=9606 GN=PHKB,0,173.611,28,22,225,1,1093,124.7,6.9,95774,36.84,20,3,metabolic process,cytosol;membrane,catalytic activity;protein binding,Pf00723,5257,ENSG00000102893.15,PHKB,16,,Glycogen Metabolism,,1,High,1
Q06323,Proteasome activator complex subunit 1 OS=Homo sapiens OX=9606 GN=PSME1 PE=1 SV=1,0,173.5,55,17,642,17,249,28.7,6.02,294075,1.66,17,3,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;proteasome,enzyme regulator activity;protein binding,"Pf02251, Pf02252",5720,ENSG00000092010.14,PSME1,14,Proteasome; Antigen processing and presentation,Proteasome Degradation,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,151,High,1
Q9BQS8,FYVE and coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FYCO1 PE=1 SV=3,0,173.018,29,33,130,33,1478,166.9,4.92,53082,5.01,31,4,cellular component movement;metabolic process;regulation of biological process;transport,endosome;Golgi;membrane;vacuole,metal ion binding;nucleotide binding;protein binding,"Pf01363, Pf02759, Pf03961, Pf13897",79443,ENSG00000163820.14,FYCO1,3,,,,0,High,1
O00764,Pyridoxal kinase OS=Homo sapiens OX=9606 GN=PDXK PE=1 SV=1,0,172.626,63,16,512,16,312,35.1,6.13,251548,17.59,16,2,cell proliferation;metabolic process;transport,cytoplasm;cytosol;extracellular;nucleus;organelle lumen,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00294, Pf08543",8566,ENSG00000160209.18,PDXK,21,Metabolic pathways; Vitamin B6 metabolism,,Vitamins B6 activation to pyridoxal phosphate; Neutrophil degranulation,9,High,1
P31946,14-3-3 protein beta/alpha OS=Homo sapiens OX=9606 GN=YWHAB PE=1 SV=3,0,172.604,57,15,1113,7,246,28.1,4.83,590521,0,15,2,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;mitochondrion;nucleus,protein binding,Pf00244,7529,ENSG00000166913.12,YWHAB,20,Viral carcinogenesis; Cell cycle; Epstein-Barr virus infection; Oocyte meiosis; Hepatitis B; PI3K-Akt signaling pathway; Hippo signaling pathway,Cell Cycle; IL-3 Signaling Pathway; Myometrial Relaxation and Contraction Pathways; Calcium Regulation in the Cardiac Cell; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,"MAP2K and MAPK activation; mTORC1-mediated signalling; Negative regulation of MAPK pathway; ARMS-mediated activation; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Translocation of GLUT4 to the plasma membrane; Rap1 signalling; Paradoxical activation of RAF signaling by kinase inactive BRAF; Frs2-mediated activation; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; Interleukin-20 family signaling; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Signaling by BRAF and RAF fusions; Signaling by Hippo; Activation of BAD and translocation to mitochondria ; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; TP53 Regulates Metabolic Genes; RAF activation; RHO GTPases activate PKNs",68,High,1
P61158,Actin-related protein 3 OS=Homo sapiens OX=9606 GN=ACTR3 PE=1 SV=3,0,172.554,37,15,375,15,418,47.3,5.88,176189,0,15,1,cell division;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane,nucleotide binding;protein binding;structural molecule activity,Pf00022,10096,ENSG00000115091.11,ACTR3,2,,Association Between Physico-Chemical Features and Toxicity Associated Pathways,EPHB-mediated forward signaling; Clathrin-mediated endocytosis; RHO GTPases Activate WASPs and WAVEs; Regulation of actin dynamics for phagocytic cup formation,16,High,1
P23528,Cofilin-1 OS=Homo sapiens OX=9606 GN=CFL1 PE=1 SV=3,0,172.549,66,16,627,7,166,18.5,8.09,295598,32.96,15,3,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,protein binding,Pf00241,1072,ENSG00000172757.12,CFL1,11,Regulation of actin cytoskeleton; Axon guidance; Pertussis; Fc gamma R-mediated phagocytosis,Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; VEGFA-VEGFR2 Signaling Pathway; EGF/EGFR Signaling Pathway; Regulation of Actin Cytoskeleton; G13 Signaling Pathway,Platelet degranulation ; Sema3A PAK dependent Axon repulsion; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; EPHB-mediated forward signaling; Regulation of actin dynamics for phagocytic cup formation; Interleukin-12 family signaling,27,High,1
P05388,60S acidic ribosomal protein P0 OS=Homo sapiens OX=9606 GN=RPLP0 PE=1 SV=1,0,172.496,48,19,385,5,317,34.3,5.97,180335,22.36,18,4,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;ribosome,protein binding;RNA binding;structural molecule activity,"Pf00428, Pf00466",6175,ENSG00000089157.15,RPLP0,12,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane; Interleukin-12 family signaling,39,High,1
O14974,Protein phosphatase 1 regulatory subunit 12A OS=Homo sapiens OX=9606 GN=PPP1R12A PE=1 SV=1,0,172.431,26,27,250,25,1030,115.2,5.4,114197,0,27,2,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;cytoskeleton;cytosol,enzyme regulator activity;protein binding;signal transducer activity,"Pf00023, Pf03961, Pf12796, Pf13606, Pf13637, Pf13857",4659,ENSG00000058272.16,PPP1R12A,12,Platelet activation; Oxytocin signaling pathway; Regulation of actin cytoskeleton; Vascular smooth muscle contraction; Focal adhesion; cGMP-PKG signaling pathway; cAMP signaling pathway; Proteoglycans in cancer,Focal Adhesion; Regulation of Actin Cytoskeleton,RHO GTPases activate PAKs; RHO GTPases Activate ROCKs; Regulation of PLK1 Activity at G2/M Transition; RHO GTPases activate PKNs; RHO GTPases activate CIT,22,High,1
O43390,Heterogeneous nuclear ribonucleoprotein R OS=Homo sapiens OX=9606 GN=HNRNPR PE=1 SV=1,0,171.867,40,21,277,17,633,70.9,8.13,125024,0,20,2,metabolic process;regulation of biological process,cytoplasm;endoplasmic reticulum;nucleus;spliceosomal complex,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",10236,ENSG00000282958.1; ENSG00000125944.18,HNRNPR,1; CHR_HSCHR1_4_CTG3,,mRNA Processing,mRNA Splicing - Major Pathway,5,High,1
P00739,Haptoglobin-related protein OS=Homo sapiens OX=9606 GN=HPR PE=2 SV=2,0,171.737,39,21,760,3,348,39,7.09,386660,32.73,19,3,metabolic process;transport,extracellular,catalytic activity;protein binding,Pf00089,3250,ENSG00000261701.6,HPR,16,African trypanosomiasis,,Scavenging of heme from plasma,4,High,1
P23396,40S ribosomal protein S3 OS=Homo sapiens OX=9606 GN=RPS3 PE=1 SV=2,0,171.442,65,19,618,19,243,26.7,9.66,265410,65.14,19,3,cell death;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;mitochondrion;nucleus;organelle lumen;ribosome,catalytic activity;DNA binding;protein binding;RNA binding;structural molecule activity,"Pf00189, Pf07650",6188,ENSG00000149273.14,RPS3,11,Ribosome,Cytoplasmic Ribosomal Proteins,"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane",38,High,1
Q53H12,"Acylglycerol kinase, mitochondrial OS=Homo sapiens OX=9606 GN=AGK PE=1 SV=2",0,171.323,41,14,376,14,422,47.1,8.09,188646,0,14,1,cell organization and biogenesis;metabolic process;transport,cytosol;membrane;mitochondrion,catalytic activity;nucleotide binding,Pf00781,55750,ENSG00000006530.15,AGK,7,Glycerolipid metabolism; Metabolic pathways,,Signaling by BRAF and RAF fusions; Glycerophospholipid biosynthesis,10,High,1
O14818,Proteasome subunit alpha type-7 OS=Homo sapiens OX=9606 GN=PSMA7 PE=1 SV=1,0,171.092,56,14,439,14,248,27.9,8.46,230981,0,14,1,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus;proteasome,catalytic activity;nucleotide binding;protein binding,"Pf00227, Pf10584",5688,ENSG00000101182.14,PSMA7,20,Proteasome,Proteasome Degradation,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,150,High,1
O95169,"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFB8 PE=1 SV=1",0,170.942,41,10,853,10,186,21.8,6.8,381582,8.12,10,2,cell organization and biogenesis;metabolic process;transport,endoplasmic reticulum;membrane;mitochondrion,catalytic activity,Pf05821,4714,ENSG00000166136.15,NDUFB8,10,Non-alcoholic fatty liver disease (NAFLD); Alzheimer's disease; Huntington's disease; Metabolic pathways; Oxidative phosphorylation; Parkinson's disease,Electron Transport Chain; Oxidative phosphorylation,Mitochondrial protein import; Complex I biogenesis; Metabolism of proteins,15,High,1
Q12907,Vesicular integral-membrane protein VIP36 OS=Homo sapiens OX=9606 GN=LMAN2 PE=1 SV=1,0,170.828,53,17,214,17,356,40.2,6.95,97993,0,17,1,regulation of biological process;transport,cell surface;endoplasmic reticulum;Golgi;membrane,metal ion binding;protein binding,Pf03388,10960,ENSG00000169223.14,LMAN2,5,Protein processing in endoplasmic reticulum,,Cargo concentration in the ER; COPII (Coat Protein 2) Mediated Vesicle Transport,10,High,1
Q9NZB2,Constitutive coactivator of PPAR-gamma-like protein 1 OS=Homo sapiens OX=9606 GN=FAM120A PE=1 SV=2,0,170.777,31,24,177,24,1118,121.8,8.88,86257,5.78,23,1,,cytoplasm;cytosol;membrane;nucleus,RNA binding,,23196,ENSG00000048828.16,FAM120A,9,,,,0,High,1
P49327,Fatty acid synthase OS=Homo sapiens OX=9606 GN=FASN PE=1 SV=3,0,170.672,18,29,130,29,2511,273.3,6.44,45915,,29,,cell differentiation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;Golgi;membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00106, Pf00107, Pf00108, Pf00109, Pf00698, Pf00975, Pf02801, Pf08242, Pf08659, Pf13602, Pf14765",2194,ENSG00000169710.8,FASN,17,AMPK signaling pathway; Insulin signaling pathway; Metabolic pathways; Fatty acid biosynthesis; Fatty acid metabolism,AMP-activated Protein Kinase (AMPK) Signaling; Sterol Regulatory Element-Binding Proteins (SREBP) signalling; SREBF and miR33 in cholesterol and lipid homeostasis; Liver X Receptor Pathway; Fatty Acid Biosynthesis; Angiopoietin Like Protein 8 Regulatory Pathway,ChREBP activates metabolic gene expression; Fatty acyl-CoA biosynthesis; Vitamin B5 (pantothenate) metabolism; Activation of gene expression by SREBF (SREBP),23,High,1
Q9NRX4,14 kDa phosphohistidine phosphatase OS=Homo sapiens OX=9606 GN=PHPT1 PE=1 SV=1,0,170.569,65,11,563,11,125,13.8,6.07,256762,4.49,11,3,metabolic process;regulation of biological process,cytoplasm;cytosol,catalytic activity;protein binding,Pf05005,29085,ENSG00000054148.17,PHPT1,9,,,,0,High,1
P16930,Fumarylacetoacetase OS=Homo sapiens OX=9606 GN=FAH PE=1 SV=2,0,170.561,49,15,319,15,419,46.3,6.95,143820,5.21,15,1,metabolic process,cytosol,catalytic activity;metal ion binding;protein binding,"Pf01557, Pf09298",2184,ENSG00000103876.11,FAH,15,Tyrosine metabolism; Metabolic pathways,Amino Acid metabolism,Phenylalanine and tyrosine catabolism,7,High,1
P00751,Complement factor B OS=Homo sapiens OX=9606 GN=CFB PE=1 SV=2,0,170.408,30,21,429,21,764,85.5,7.06,204384,2.29,20,3,defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,catalytic activity;protein binding,"Pf00084, Pf00089, Pf00092, Pf13519",629,ENSG00000243649.8; ENSG00000242335.8; ENSG00000243570.9; ENSG00000239754.9; ENSG00000241534.9,CFB,6; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_DBB_CTG1,Complement and coagulation cascades; Staphylococcus aureus infection,Complement Activation; Complement and Coagulation Cascades,Alternative complement activation; Regulation of Complement cascade; Activation of C3 and C5,11,High,1
Q9H2G2,STE20-like serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=SLK PE=1 SV=1,0,170.227,27,26,189,26,1235,142.6,5.15,88885,,26,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf07714, Pf12474, Pf14531",9748,ENSG00000065613.13,SLK,10,Oocyte meiosis,,,1,High,1
Q96GK7,Fumarylacetoacetate hydrolase domain-containing protein 2A OS=Homo sapiens OX=9606 GN=FAHD2A PE=1 SV=1,0,170.162,48,12,401,12,314,34.6,8.24,199860,7.89,11,2,metabolic process,,catalytic activity;metal ion binding,Pf01557,51011,ENSG00000115042.9,FAHD2A,2,,,,0,High,1
P24298,Alanine aminotransferase 1 OS=Homo sapiens OX=9606 GN=GPT PE=1 SV=3,0,170.132,41,14,374,14,496,54.6,7.18,182127,16.87,13,2,metabolic process,cytoplasm;cytosol,catalytic activity,Pf00155,2875,ENSG00000167701.13,GPT,8,"Carbon metabolism; 2-Oxocarboxylic acid metabolism; Alanine, aspartate and glutamate metabolism; Arginine biosynthesis; Metabolic pathways; Biosynthesis of amino acids",Alanine and aspartate metabolism; Cori Cycle,Amino acid synthesis and interconversion (transamination),11,High,1
Q93009,Ubiquitin carboxyl-terminal hydrolase 7 OS=Homo sapiens OX=9606 GN=USP7 PE=1 SV=2,0,170.036,31,26,154,26,1102,128.2,5.55,70509,,26,,cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;cytosol;nucleus,catalytic activity;protein binding,"Pf00443, Pf00917, Pf12436, Pf13423, Pf14533",7874,ENSG00000187555.14,USP7,16,Herpes simplex infection; FoxO signaling pathway; Epstein-Barr virus infection; Viral carcinogenesis,Regulation of toll-like receptor signaling pathway,Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Ub-specific processing proteases; Gap-filling DNA repair synthesis and ligation in TC-NER; Regulation of TP53 Degradation; Dual incision in TC-NER; Formation of TC-NER Pre-Incision Complex; Regulation of PTEN localization,29,High,1
P61201,COP9 signalosome complex subunit 2 OS=Homo sapiens OX=9606 GN=COPS2 PE=1 SV=1,0,169.944,44,17,341,17,443,51.6,5.53,158720,11.2,16,3,cell differentiation;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,protein binding;signal transducer activity,"Pf01399, Pf10075",9318,ENSG00000166200.14,COPS2,15,,,Cargo recognition for clathrin-mediated endocytosis; DNA Damage Recognition in GG-NER; Formation of TC-NER Pre-Incision Complex; Neddylation,13,High,1
P54920,Alpha-soluble NSF attachment protein OS=Homo sapiens OX=9606 GN=NAPA PE=1 SV=3,0,169.561,62,14,273,12,295,33.2,5.36,133566,8.25,13,3,cell communication;cell differentiation;cell organization and biogenesis;regulation of biological process;transport,cytosol;membrane,protein binding,Pf14938,8775,ENSG00000105402.7,NAPA,19,Synaptic vesicle cycle,Synaptic Vesicle Pathway,COPI-dependent Golgi-to-ER retrograde traffic; Intra-Golgi traffic; COPII (Coat Protein 2) Mediated Vesicle Transport; COPI-mediated anterograde transport; Retrograde transport at the Trans-Golgi-Network; Golgi Associated Vesicle Biogenesis,19,High,1
Q8TAT6,Nuclear protein localization protein 4 homolog OS=Homo sapiens OX=9606 GN=NPLOC4 PE=1 SV=3,0,169.473,39,19,218,19,608,68.1,6.38,97141,2.48,18,2,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus,metal ion binding;protein binding,"Pf05020, Pf05021, Pf11543",55666,ENSG00000182446.13,NPLOC4,17,Protein processing in endoplasmic reticulum,,Translesion Synthesis by POLH,5,High,1
Q14123,"Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C OS=Homo sapiens OX=9606 GN=PDE1C PE=1 SV=1",0,169.429,35,19,212,17,709,80.7,8.82,83138,58.56,14,9,regulation of biological process;response to stimulus,cytosol,catalytic activity;metal ion binding;protein binding,"Pf00233, Pf08499, Pf13985",5137,ENSG00000154678.16,PDE1C,7,Taste transduction; Olfactory transduction; Renin secretion; Calcium signaling pathway; Morphine addiction; Purine metabolism,G Protein Signaling Pathways,Signaling by GPCR; Cam-PDE 1 activation,18,High,1
Q13283,Ras GTPase-activating protein-binding protein 1 OS=Homo sapiens OX=9606 GN=G3BP1 PE=1 SV=1,0,169.426,50,17,318,16,466,52.1,5.52,129741,0,17,1,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding,"Pf00076, Pf02136, Pf13893, Pf14259",10146,ENSG00000145907.14,G3BP1,5,,,,0,High,1
Q93100,Phosphorylase b kinase regulatory subunit beta OS=Homo sapiens OX=9606 GN=PHKB PE=1 SV=3,0,169.03,28,22,213,1,1093,124.8,6.95,95774,2.58,20,3,metabolic process,cytosol;membrane,catalytic activity;protein binding,Pf00723,5257,ENSG00000102893.15,PHKB,16,Calcium signaling pathway; Insulin signaling pathway; Glucagon signaling pathway,Glycogen Metabolism,Glycogen breakdown (glycogenolysis),8,High,1
Q14254,Flotillin-2 OS=Homo sapiens OX=9606 GN=FLOT2 PE=1 SV=2,0,168.821,50,21,278,21,428,47,5.25,132328,,21,,cell organization and biogenesis;regulation of biological process,cytoskeleton;endosome;membrane,protein binding,Pf01145,2319,ENSG00000132589.15,FLOT2,17,Insulin signaling pathway,Angiopoietin Like Protein 8 Regulatory Pathway; Insulin Signaling,Synaptic adhesion-like molecules,6,High,1
P43304,"Glycerol-3-phosphate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=GPD2 PE=1 SV=3",0,168.688,50,27,272,27,727,80.8,7.69,118283,2.25,27,1,metabolic process;transport,membrane;mitochondrion,catalytic activity;metal ion binding,"Pf00036, Pf00890, Pf01266, Pf03486, Pf07992, Pf12831, Pf13499",2820,ENSG00000115159.15,GPD2,2,Glycerophospholipid metabolism,Fatty Acid Beta Oxidation,Triglyceride catabolism; Synthesis of PA,9,High,1
O00203,AP-3 complex subunit beta-1 OS=Homo sapiens OX=9606 GN=AP3B1 PE=1 SV=3,0,168.555,32,30,192,30,1094,121.2,6.04,76495,,30,,cell organization and biogenesis;cellular component movement;coagulation;regulation of biological process;transport,Golgi;membrane,protein binding,"Pf01602, Pf13646, Pf14796, Pf14797",8546,ENSG00000132842.13,AP3B1,5,Lysosome,,Signaling by BRAF and RAF fusions; Golgi Associated Vesicle Biogenesis,10,High,1
O00232,26S proteasome non-ATPase regulatory subunit 12 OS=Homo sapiens OX=9606 GN=PSMD12 PE=1 SV=3,0,168.411,46,20,315,20,456,52.9,7.65,150763,7.28,19,2,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;membrane;organelle lumen;proteasome,catalytic activity;protein binding,Pf01399,5718,ENSG00000197170.9,PSMD12,17,Epstein-Barr virus infection; Proteasome,Proteasome Degradation; Parkin-Ubiquitin Proteasomal System pathway,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Neutrophil degranulation; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,153,High,1
P04196,Histidine-rich glycoprotein OS=Homo sapiens OX=9606 GN=HRG PE=1 SV=1,0,168.383,22,17,309,17,525,59.5,7.5,155519,0,17,2,coagulation;defense response;regulation of biological process;response to stimulus;transport,cell surface;endosome;extracellular;membrane;organelle lumen;vacuole,enzyme regulator activity;metal ion binding;protein binding,,3273,ENSG00000113905.4,HRG,3,,,Platelet degranulation ; Dissolution of Fibrin Clot,5,High,1
Q8NDY3,[Protein ADP-ribosylarginine] hydrolase-like protein 1 OS=Homo sapiens OX=9606 GN=ADPRHL1 PE=2 SV=1,0,168.232,43,16,492,16,354,40.1,5.85,228978,134.13,12,8,metabolic process;regulation of biological process;transport,,catalytic activity;enzyme regulator activity;metal ion binding;protein binding,Pf03747,113622,ENSG00000153531.13,ADPRHL1,13,,,,0,High,1
P51884,Lumican OS=Homo sapiens OX=9606 GN=LUM PE=1 SV=2,0,168.214,36,14,845,14,338,38.4,6.61,441393,2.16,14,3,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,extracellular;organelle lumen,protein binding;structural molecule activity,"Pf01462, Pf12799, Pf13855",4060,ENSG00000139329.4,LUM,12,Proteoglycans in cancer,,ECM proteoglycans; Integrin cell surface interactions; Keratan sulfate biosynthesis; Defective CHST6 causes MCDC1; Defective ST3GAL3 causes MCT12 and EIEE15; Keratan sulfate degradation; Defective B4GALT1 causes B4GALT1-CDG (CDG-2d),16,High,1
O60343-3,Isoform 3 of TBC1 domain family member 4 OS=Homo sapiens OX=9606 GN=TBC1D4,0,167.629,26,24,145,24,1290,145.6,7.05,62018,15.73,22,3,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytosol;membrane,enzyme regulator activity;protein binding,"Pf00566, Pf00640, Pf11830",9882,ENSG00000136111.12,TBC1D4,13,,Insulin Signaling,,1,High,1
P56385,"ATP synthase subunit e, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5ME PE=1 SV=2",0,167.392,67,17,1687,17,69,7.9,9.35,848688,152.98,15,3,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion,catalytic activity;transporter activity,Pf05680,521,ENSG00000169020.9,ATP5I,4,Metabolic pathways; Oxidative phosphorylation,Electron Transport Chain; Oxidative phosphorylation,Cristae formation; Formation of ATP by chemiosmotic coupling,11,High,1
P10155,60 kDa SS-A/Ro ribonucleoprotein OS=Homo sapiens OX=9606 GN=RO60 PE=1 SV=2,0,167.121,35,16,226,16,538,60.6,8.03,103528,0,16,4,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,metal ion binding;RNA binding,"Pf05731, Pf09967, Pf13519",6738,ENSG00000116747.12,TROVE2,1,Systemic lupus erythematosus,,,1,High,1
Q15031,"Probable leucine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=LARS2 PE=1 SV=2",0,166.635,35,24,203,24,903,101.9,8.22,91776,3.2,23,1,cell organization and biogenesis;metabolic process;regulation of biological process,mitochondrion;organelle lumen,catalytic activity;nucleotide binding,"Pf00133, Pf08264, Pf09334, Pf13603",23395,ENSG00000011376.9,LARS2,3,Aminoacyl-tRNA biosynthesis,Amino Acid metabolism,Mitochondrial tRNA aminoacylation,6,High,1
P34897,"Serine hydroxymethyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=SHMT2 PE=1 SV=3",0,166.288,52,21,329,20,504,56,8.53,143196,0,21,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;membrane;mitochondrion;nucleus;organelle lumen,catalytic activity;protein binding,Pf00464,6472,ENSG00000182199.10,SHMT2,12,"One carbon pool by folate; Glycine, serine and threonine metabolism; Glyoxylate and dicarboxylate metabolism; Biosynthesis of amino acids; Carbon metabolism; Metabolic pathways; Antifolate resistance",Vitamin B12 Metabolism; Folate Metabolism; One Carbon Metabolism; Trans-sulfuration and one carbon metabolism; One carbon metabolism and related pathways,Metabolism of folate and pterines,16,High,1
Q15233,Non-POU domain-containing octamer-binding protein OS=Homo sapiens OX=9606 GN=NONO PE=1 SV=4,0,166.173,49,20,209,19,471,54.2,8.95,99296,,20,,defense response;metabolic process;regulation of biological process;response to stimulus,membrane;nucleus,DNA binding;protein binding;RNA binding,"Pf00076, Pf08075, Pf13893, Pf14259",4841,ENSG00000147140.15,NONO,X,,mRNA Processing,,1,High,1
Q9BXN1,Asporin OS=Homo sapiens OX=9606 GN=ASPN PE=1 SV=2,0,166.166,44,15,343,15,380,43.4,7.08,158217,7.8,14,4,regulation of biological process;response to stimulus,cytoplasm;extracellular,enzyme regulator activity;metal ion binding;protein binding,"Pf01462, Pf12799, Pf13855",54829,ENSG00000106819.11,ASPN,9,,,ECM proteoglycans,2,High,1
Q10567,AP-1 complex subunit beta-1 OS=Homo sapiens OX=9606 GN=AP1B1 PE=1 SV=2,0,166.035,35,26,316,16,949,104.6,5.06,133753,0,26,1,regulation of biological process;transport,cytosol;Golgi;membrane,protein binding;transporter activity,"Pf01602, Pf02883, Pf09066, Pf12717, Pf13646",162,,AP1B1,22,Lysosome,,Nef mediated downregulation of MHC class I complex cell surface expression; MHC class II antigen presentation; Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis,17,High,1
Q13162,Peroxiredoxin-4 OS=Homo sapiens OX=9606 GN=PRDX4 PE=1 SV=1,0,165.9,56,19,387,11,271,30.5,6.29,190631,7.06,18,3,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;endoplasmic reticulum;extracellular;mitochondrion;nucleus;organelle lumen,antioxidant activity;catalytic activity;protein binding,"Pf00578, Pf08534, Pf10417",10549,ENSG00000123131.12,PRDX4,X,,Selenium Micronutrient Network,Neutrophil degranulation,4,High,1
P46926,Glucosamine-6-phosphate isomerase 1 OS=Homo sapiens OX=9606 GN=GNPDA1 PE=1 SV=1,0,165.892,58,13,271,8,289,32.6,6.92,121204,1.94,13,1,metabolic process,cytoplasm;cytosol,catalytic activity;protein binding,Pf01182,10007,ENSG00000113552.15,GNPDA1,5,Amino sugar and nucleotide sugar metabolism; Metabolic pathways,,Glycolysis,6,High,1
O00507,Probable ubiquitin carboxyl-terminal hydrolase FAF-Y OS=Homo sapiens OX=9606 GN=USP9Y PE=2 SV=2,0,165.886,10,25,216,1,2555,290.9,5.86,95280,0,25,1,cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm,catalytic activity;protein binding,"Pf00443, Pf13423",8287,ENSG00000114374.12,USP9Y,Y,,,,0,High,1
P51970,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 OS=Homo sapiens OX=9606 GN=NDUFA8 PE=1 SV=3,0,165.641,46,16,1319,16,172,20.1,7.65,691439,11.11,15,2,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion,catalytic activity;protein binding,Pf06747,4702,ENSG00000119421.6,NDUFA8,9,Oxidative phosphorylation; Metabolic pathways; Parkinson's disease; Non-alcoholic fatty liver disease (NAFLD); Alzheimer's disease; Huntington's disease,Electron Transport Chain; Oxidative phosphorylation,Complex I biogenesis,13,High,1
O43615,Mitochondrial import inner membrane translocase subunit TIM44 OS=Homo sapiens OX=9606 GN=TIMM44 PE=1 SV=2,0,164.679,37,18,508,18,452,51.3,8.32,242109,0,18,3,transport,membrane;mitochondrion;organelle lumen,nucleotide binding;protein binding,"Pf04280, Pf07091",10469,ENSG00000104980.7,TIMM44,19,,,Mitochondrial protein import; Metabolism of proteins,2,High,1
O76024,Wolframin OS=Homo sapiens OX=9606 GN=WFS1 PE=1 SV=2,0,164.668,26,21,247,21,890,100.2,8.05,120949,,21,,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;membrane;organelle lumen;proteasome,protein binding,,7466,ENSG00000109501.13,WFS1,4,Protein processing in endoplasmic reticulum,,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); XBP1(S) activates chaperone genes,8,High,1
Q9NVA2,Septin-11 OS=Homo sapiens OX=9606 GN=SEPTIN11 PE=1 SV=3,0,164.631,45,19,335,10,429,49.4,6.81,161962,0,19,2,cell division;cell organization and biogenesis,cytoplasm;cytoskeleton,nucleotide binding;protein binding,Pf00735,55752,ENSG00000138758.11,SEPT11,4,Bacterial invasion of epithelial cells,,,1,High,1
A2RRP1,Neuroblastoma-amplified sequence OS=Homo sapiens OX=9606 GN=NBAS PE=1 SV=2,0,164.452,20,35,156,35,2371,268.4,5.96,63540,0,35,1,metabolic process;regulation of biological process;transport,cytoplasm;cytosol;endoplasmic reticulum;membrane,protein binding,"Pf08314, Pf15492",51594,ENSG00000151779.12,NBAS,2,,,COPI-dependent Golgi-to-ER retrograde traffic,5,High,1
Q9UKG1,DCC-interacting protein 13-alpha OS=Homo sapiens OX=9606 GN=APPL1 PE=1 SV=1,0,164.212,32,19,262,18,709,79.6,5.41,118448,0,19,1,cell proliferation;regulation of biological process;response to stimulus,cytoplasm;cytosol;endosome;membrane;nucleus,protein binding,"Pf00169, Pf00640",26060,ENSG00000157500.10,APPL1,3,Colorectal cancer; Longevity regulating pathway; Pathways in cancer,Follicle Stimulating Hormone (FSH) signaling pathway,Ligand-independent caspase activation via DCC,8,High,1
A8MXV4,Nucleoside diphosphate-linked moiety X motif 19 OS=Homo sapiens OX=9606 GN=NUDT19 PE=1 SV=1,0,163.549,48,14,281,14,375,42.2,7.64,128689,13.17,14,4,metabolic process,mitochondrion;organelle lumen,catalytic activity;metal ion binding;protein binding,,390916,ENSG00000213965.3,NUDT19,19,Peroxisome,,Peroxisomal lipid metabolism,5,High,1
Q99797,Mitochondrial intermediate peptidase OS=Homo sapiens OX=9606 GN=MIPEP PE=1 SV=2,0,163.415,41,24,230,24,713,80.6,7.05,103524,,24,,metabolic process,mitochondrion;organelle lumen,catalytic activity;metal ion binding,Pf01432,4285,ENSG00000027001.9,MIPEP,13,,,,0,High,1
Q8N465,"D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=D2HGDH PE=1 SV=3",0,163.238,36,12,174,12,521,56.4,7.99,88675,18.98,12,3,metabolic process;response to stimulus,mitochondrion;organelle lumen,catalytic activity;nucleotide binding,"Pf01565, Pf02913",728294,ENSG00000180902.17,D2HGDH,2,,,Interconversion of 2-oxoglutarate and 2-hydroxyglutarate,4,High,1
Q5T5P2,Sickle tail protein homolog OS=Homo sapiens OX=9606 GN=KIAA1217 PE=1 SV=2,0,163.112,23,34,164,34,1943,214,7.06,60117,8.2,33,1,development,cytoplasm,protein binding,,56243,ENSG00000120549.17,KIAA1217,10,,,,0,High,1
Q16853,Membrane primary amine oxidase OS=Homo sapiens OX=9606 GN=AOC3 PE=1 SV=3,0,162.538,28,16,343,16,763,84.6,6.52,158499,1.91,16,2,defense response;metabolic process;regulation of biological process;response to stimulus,cell surface;cytoplasm;endoplasmic reticulum;endosome;Golgi;membrane,catalytic activity;metal ion binding;protein binding,"Pf01179, Pf02727, Pf02728",8639,ENSG00000131471.6,AOC3,17,"Metabolic pathways; beta-Alanine metabolism; Tyrosine metabolism; Phenylalanine metabolism; Glycine, serine and threonine metabolism",Amino Acid metabolism,Phase I - Functionalization of compounds,9,High,1
P17302,Gap junction alpha-1 protein OS=Homo sapiens OX=9606 GN=GJA1 PE=1 SV=2,0,162.522,33,10,343,10,382,43,8.76,166828,49.71,10,4,cell communication;cell death;cell organization and biogenesis;cellular homeostasis;defense response;regulation of biological process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;endosome;Golgi;membrane;mitochondrion;vacuole,protein binding;signal transducer activity;transporter activity,"Pf00029, Pf03508, Pf10582",2697,ENSG00000152661.7,GJA1,6,Arrhythmogenic right ventricular cardiomyopathy (ARVC); Gap junction,TarBasePathway; Arrhythmogenic Right Ventricular Cardiomyopathy; Corticotropin-releasing hormone signaling pathway; Spinal Cord Injury; Myometrial Relaxation and Contraction Pathways; Wnt Signaling Pathway Netpath; VEGFA-VEGFR2 Signaling Pathway; EGF/EGFR Signaling Pathway; Calcium Regulation in the Cardiac Cell; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,Transport of connexins along the secretory pathway; c-src mediated regulation of Cx43 function and closure of gap junctions; Formation of annular gap junctions; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Oligomerization of connexins into connexons,25,High,1
Q15435,Protein phosphatase 1 regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PPP1R7 PE=1 SV=1,0,162.3,50,15,322,15,360,41.5,4.91,154275,0,15,2,regulation of biological process,chromosome;cytoplasm;nucleus,enzyme regulator activity;protein binding,"Pf12799, Pf13855, Pf14580",5510,ENSG00000115685.14,PPP1R7,2,,,,0,High,1
P46019,"Phosphorylase b kinase regulatory subunit alpha, liver isoform OS=Homo sapiens OX=9606 GN=PHKA2 PE=1 SV=1",0,162.14,25,22,141,20,1235,138.3,6.44,63852,,22,,metabolic process,cytosol;membrane,catalytic activity;protein binding,Pf00723,5256,ENSG00000044446.11,PHKA2,X,Calcium signaling pathway; Insulin signaling pathway; Glucagon signaling pathway,Type II diabetes mellitus; Glycogen Metabolism,Glycogen breakdown (glycogenolysis),9,High,1
P05556,Integrin beta-1 OS=Homo sapiens OX=9606 GN=ITGB1 PE=1 SV=2,0,162.09,25,17,631,2,798,88.4,5.39,296592,16.41,16,7,cell differentiation;cell growth;cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;endosome;membrane,enzyme regulator activity;metal ion binding;protein binding;receptor activity;signal transducer activity,"Pf00362, Pf07965, Pf08725",3688,ENSG00000150093.18,ITGB1,10,Cell adhesion molecules (CAMs); Shigellosis; Arrhythmogenic right ventricular cardiomyopathy (ARVC); ECM-receptor interaction; Regulation of actin cytoskeleton; Pertussis; Leishmaniasis; Hypertrophic cardiomyopathy (HCM); Bacterial invasion of epithelial cells; Focal adhesion; Pathogenic Escherichia coli infection; Axon guidance; Toxoplasmosis; Small cell lung cancer; Pathways in cancer; Leukocyte transendothelial migration; Rap1 signaling pathway; Platelet activation; Proteoglycans in cancer; Dilated cardiomyopathy; PI3K-Akt signaling pathway; Phagosome,Integrin-mediated Cell Adhesion; Prolactin Signaling Pathway; Neural Crest Differentiation; Arrhythmogenic Right Ventricular Cardiomyopathy; Pathogenic Escherichia coli infection; Primary Focal Segmental Glomerulosclerosis FSGS; Focal Adhesion; Signaling of Hepatocyte Growth Factor Receptor; Rac1/Pak1/p38/MMP-2 pathway; TGF-beta Signaling Pathway; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; VEGFA-VEGFR2 Signaling Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,Integrin cell surface interactions; Signal transduction by L1; Basigin interactions; MET activates PTK2 signaling; Molecules associated with elastic fibres; Platelet Adhesion to exposed collagen; Syndecan interactions; CHL1 interactions; ECM proteoglycans; Laminin interactions; Localization of the PINCH-ILK-PARVIN complex to focal adhesions; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; MET interacts with TNS proteins; Other semaphorin interactions; RHO GTPases Activate Formins; Interleukin-4 and 13 signaling; Fibronectin matrix formation,74,High,1
Q9BR39,Junctophilin-2 OS=Homo sapiens OX=9606 GN=JPH2 PE=1 SV=2,0,162.014,42,17,225,17,696,74.2,8.72,91519,66.17,14,6,cellular homeostasis;regulation of biological process;transport,endoplasmic reticulum;membrane,protein binding;transporter activity,Pf02493,57158,ENSG00000149596.6,JPH2,20,,,,0,High,1
P50851-2,Isoform 2 of Lipopolysaccharide-responsive and beige-like anchor protein OS=Homo sapiens OX=9606 GN=LRBA,0,161.95,16,35,148,29,2851,317.5,5.57,56618,3.89,34,1,,endoplasmic reticulum;Golgi;membrane;vacuole,,"Pf02138, Pf06469, Pf08385, Pf13385, Pf14844",987,ENSG00000198589.10,LRBA,4,,,,0,High,1
Q9P2B2,Prostaglandin F2 receptor negative regulator OS=Homo sapiens OX=9606 GN=PTGFRN PE=1 SV=2,0,161.923,29,26,212,26,879,98.5,6.61,90812,1.86,25,3,cell organization and biogenesis,cell surface;endoplasmic reticulum;Golgi;membrane,protein binding,Pf07679,5738,ENSG00000134247.9,PTGFRN,1,,,,0,High,1
O14786,Neuropilin-1 OS=Homo sapiens OX=9606 GN=NRP1 PE=1 SV=3,0,161.733,32,21,189,21,923,103.1,5.88,84966,0,20,1,cell communication;cell differentiation;cell growth;cell organization and biogenesis;cellular component movement;development;regulation of biological process;response to stimulus;transport,cell surface;cytosol;endosome;extracellular;membrane,catalytic activity;enzyme regulator activity;metal ion binding;protein binding;receptor activity;signal transducer activity,"Pf00431, Pf00629, Pf00754, Pf11980",8829,ENSG00000099250.17,NRP1,10,Axon guidance; HTLV-I infection,,CHL1 interactions; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Sema3A PAK dependent Axon repulsion; Signal transduction by L1; Signaling by ROBO receptors; CRMPs in Sema3A signaling; Neurophilin interactions with VEGF and VEGFR,16,High,1
Q9UL46,Proteasome activator complex subunit 2 OS=Homo sapiens OX=9606 GN=PSME2 PE=1 SV=4,0,161.683,58,14,263,14,239,27.4,5.73,145516,,14,,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;proteasome,enzyme regulator activity;protein binding,"Pf02251, Pf02252",5721,ENSG00000100911.15,PSME2,14,Proteasome; Antigen processing and presentation,Proteasome Degradation,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Interleukin-12 family signaling; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,153,High,1
Q9ULP0-6,Isoform 6 of Protein NDRG4 OS=Homo sapiens OX=9606 GN=NDRG4,0,161.645,45,10,369,10,391,42.9,5.74,154056,171.15,7,4,cell differentiation;cell growth;cell proliferation;cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;mitochondrion,protein binding,"Pf03096, Pf12697",65009,ENSG00000103034.14,NDRG4,16,,,,0,High,1
Q92905,COP9 signalosome complex subunit 5 OS=Homo sapiens OX=9606 GN=COPS5 PE=1 SV=4,0,161.616,62,16,277,16,334,37.6,6.54,123690,4.35,16,2,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,chromosome;cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;protein binding;RNA binding,"Pf01398, Pf14464",10987,ENSG00000121022.13,COPS5,8,,TGF-beta Signaling Pathway,Cargo recognition for clathrin-mediated endocytosis; DNA Damage Recognition in GG-NER; Formation of TC-NER Pre-Incision Complex; Neddylation,14,High,1
Q03154,Aminoacylase-1 OS=Homo sapiens OX=9606 GN=ACY1 PE=1 SV=1,0,161.554,63,18,211,18,408,45.9,6.18,83705,0,18,2,metabolic process,cytoplasm;cytosol,catalytic activity;metal ion binding;protein binding,"Pf01546, Pf07687",95,ENSG00000243989.8,ACY1,3,2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids; Metabolic pathways; Arginine biosynthesis,Urea cycle and metabolism of amino groups,Defective ACY1 causes encephalopathy; Aflatoxin activation and detoxification,12,High,1
Q08380,Galectin-3-binding protein OS=Homo sapiens OX=9606 GN=LGALS3BP PE=1 SV=1,0,161.478,22,14,331,14,585,65.3,5.27,168045,,14,,defense response;regulation of biological process;response to stimulus;transport,extracellular;membrane;organelle lumen,protein binding;receptor activity,"Pf00530, Pf07707",3959,ENSG00000108679.12,LGALS3BP,17,,,Platelet degranulation,4,High,1
A0AVT1,Ubiquitin-like modifier-activating enzyme 6 OS=Homo sapiens OX=9606 GN=UBA6 PE=1 SV=1,0,161.403,29,23,164,23,1052,117.9,6.14,74091,,23,,metabolic process;response to stimulus,cytoplasm;cytosol,catalytic activity;nucleotide binding;protein binding,"Pf00899, Pf02134, Pf09358, Pf10585",55236,ENSG00000033178.12,UBA6,4,Ubiquitin mediated proteolysis,,Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation,9,High,1
Q9H4A3,Serine/threonine-protein kinase WNK1 OS=Homo sapiens OX=9606 GN=WNK1 PE=1 SV=2,0,161.374,14,25,138,23,2382,250.6,6.34,62140,0,25,1,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane,catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf07714, Pf12202",65125,ENSG00000060237.16,WNK1,12,,,Stimuli-sensing channels,3,High,1
P09417,Dihydropteridine reductase OS=Homo sapiens OX=9606 GN=QDPR PE=1 SV=2,0,161.361,52,10,463,10,244,25.8,7.37,243198,,10,,metabolic process;response to stimulus,cytoplasm;cytosol;mitochondrion,catalytic activity;nucleotide binding;protein binding,,5860,ENSG00000151552.11,QDPR,4,Folate biosynthesis; Metabolic pathways,,Phenylalanine and tyrosine catabolism,6,High,1
P17844,Probable ATP-dependent RNA helicase DDX5 OS=Homo sapiens OX=9606 GN=DDX5 PE=1 SV=1,0,161.301,40,22,233,15,614,69.1,8.92,106393,1.83,22,2,cell differentiation;cell growth;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;membrane;nucleus;spliceosomal complex,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00270, Pf00271, Pf08061",1655,ENSG00000108654.13,DDX5,17,Proteoglycans in cancer; Transcriptional misregulation in cancer; Spliceosome,,mRNA Splicing - Major Pathway,7,High,1
P39656,Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit OS=Homo sapiens OX=9606 GN=DDOST PE=1 SV=4,0,161.275,43,15,362,15,456,50.8,6.55,180040,0,15,1,metabolic process;response to stimulus;transport,endoplasmic reticulum;membrane,catalytic activity;protein binding,Pf03345,1650,ENSG00000244038.9,DDOST,1,Protein processing in endoplasmic reticulum; Metabolic pathways; N-Glycan biosynthesis,AGE/RAGE pathway,Advanced glycosylation endproduct receptor signaling; Asparagine N-linked glycosylation; Neutrophil degranulation; SRP-dependent cotranslational protein targeting to membrane,13,High,1
Q969V3,Nicalin OS=Homo sapiens OX=9606 GN=NCLN PE=1 SV=2,0,161.254,41,20,127,20,563,62.9,6.89,50967,,20,,metabolic process;regulation of biological process,endoplasmic reticulum;membrane,protein binding,"Pf04389, Pf05450",56926,ENSG00000125912.10,NCLN,19,,,,0,High,1
P61160,Actin-related protein 2 OS=Homo sapiens OX=9606 GN=ACTR2 PE=1 SV=1,0,161.039,49,15,332,15,394,44.7,6.74,155480,3.01,14,1,cell division;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;extracellular;membrane;organelle lumen,nucleotide binding;protein binding;structural molecule activity,Pf00022,10097,ENSG00000138071.13,ACTR2,2,,Association Between Physico-Chemical Features and Toxicity Associated Pathways; ESC Pluripotency Pathways,EPHB-mediated forward signaling; Neutrophil degranulation; Clathrin-mediated endocytosis; RHO GTPases Activate WASPs and WAVEs; Regulation of actin dynamics for phagocytic cup formation,18,High,1
Q02750,Dual specificity mitogen-activated protein kinase kinase 1 OS=Homo sapiens OX=9606 GN=MAP2K1 PE=1 SV=2,0,160.818,52,19,788,13,393,43.4,6.62,203717,2.78,18,1,cell differentiation;cell proliferation;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;endosome;Golgi;membrane;mitochondrion;nucleus,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf07714",5604,ENSG00000169032.9,MAP2K1,15,Apoptosis; Toll-like receptor signaling pathway; cAMP signaling pathway; HIF-1 signaling pathway; B cell receptor signaling pathway; Natural killer cell mediated cytotoxicity; Regulation of actin cytoskeleton; GnRH signaling pathway; Vascular smooth muscle contraction; cGMP-PKG signaling pathway; Endometrial cancer; Renal cell carcinoma; Choline metabolism in cancer; Ras signaling pathway; TNF signaling pathway; Prolactin signaling pathway; Progesterone-mediated oocyte maturation; Thyroid hormone signaling pathway; Melanogenesis; Fc epsilon RI signaling pathway; Estrogen signaling pathway; Serotonergic synapse; Central carbon metabolism in cancer; Acute myeloid leukemia; Pathways in cancer; Melanoma; Sphingolipid signaling pathway; Signaling pathways regulating pluripotency of stem cells; Hepatitis B; Neurotrophin signaling pathway; Colorectal cancer; Long-term depression; Endocrine resistance; Osteoclast differentiation; Phospholipase D signaling pathway; Oxytocin signaling pathway; Glioma; Proteoglycans in cancer; Alcoholism; Cholinergic synapse; T cell receptor signaling pathway; FoxO signaling pathway; Non-small cell lung cancer; Prostate cancer; Bladder cancer; VEGF signaling pathway; Oocyte meiosis; Chronic myeloid leukemia; mTOR signaling pathway; MicroRNAs in cancer; Focal adhesion; Pancreatic cancer; EGFR tyrosine kinase inhibitor resistance; Insulin signaling pathway; Prion diseases; Gap junction; PI3K-Akt signaling pathway; Dorso-ventral axis formation; Long-term potentiation; Influenza A; ErbB signaling pathway; Chemokine signaling pathway; Breast cancer; Fc gamma R-mediated phagocytosis; MAPK signaling pathway; Thyroid cancer; Rap1 signaling pathway,"IL-5 Signaling Pathway; Osteopontin Signaling; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated Cell Adhesion; IL-1 signaling pathway; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; Human Thyroid Stimulating Hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin Signaling Pathway; IL-7 Signaling Pathway; Endothelin Pathways; IL-9 Signaling Pathway; Signaling Pathways in Glioblastoma; B Cell Receptor Signaling Pathway; AGE/RAGE pathway; Interleukin-11 Signaling Pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Aryl Hydrocarbon Receptor; Common Pathways Underlying Drug Addiction; Structural Pathway of Interleukin 1 (IL-1); Cardiac Hypertrophic Response; Bladder Cancer; IL-3 Signaling Pathway; Kit receptor signaling pathway; Focal Adhesion; Signaling of Hepatocyte Growth Factor Receptor; IL-6 signaling pathway; TGF-beta Signaling Pathway; BDNF-TrkB Signaling; Association Between Physico-Chemical Features and Toxicity Associated Pathways; MAPK Signaling Pathway; T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; Chemokine signaling pathway; ESC Pluripotency Pathways; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; MAPK Cascade; EGF/EGFR Signaling Pathway; Insulin Signaling; IL-2 Signaling Pathway; Regulation of Actin Cytoskeleton; EPO Receptor Signaling; Senescence and Autophagy in Cancer; ErbB Signaling Pathway; T-Cell antigen Receptor (TCR)  Signaling Pathway; Estrogen signaling pathway; Serotonin Receptor 2 and ELK-SRF/GATA4 signaling; Serotonin Receptor 4/6/7 and NR3C Signaling; Toll-like receptor signaling pathway",MAP2K and MAPK activation; Uptake and function of anthrax toxins; MAP3K8 (TPL2)-dependent MAPK1/3 activation; Activated TLR4 signalling; Negative feedback regulation of MAPK pathway; Interleukin-1 family signaling; Paradoxical activation of RAF signaling by kinase inactive BRAF; Interleukin-20 family signaling; Signaling by BRAF and RAF fusions; Signal transduction by L1; MAPK3 (ERK1) activation; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; RAF activation,172,High,1
Q99447,Ethanolamine-phosphate cytidylyltransferase OS=Homo sapiens OX=9606 GN=PCYT2 PE=1 SV=1,0,160.589,59,16,264,16,389,43.8,6.92,119075,0,16,3,metabolic process,membrane,catalytic activity,Pf01467,5833,ENSG00000185813.10,PCYT2,17,Glycerophospholipid metabolism; Metabolic pathways,Kennedy pathway; One carbon metabolism and related pathways,Synthesis of PE,9,High,1
P31942,Heterogeneous nuclear ribonucleoprotein H3 OS=Homo sapiens OX=9606 GN=HNRNPH3 PE=1 SV=2,0,160.431,52,13,154,13,346,36.9,6.87,81647,0,13,2,cell differentiation;metabolic process,nucleus;spliceosomal complex,protein binding;RNA binding,"Pf00076, Pf14259",3189,ENSG00000096746.17,HNRNPH3,10,,,,0,High,1
O75147,Obscurin-like protein 1 OS=Homo sapiens OX=9606 GN=OBSL1 PE=1 SV=4,0,160.313,18,24,204,24,1896,206.8,5.63,87055,16.46,20,6,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytoskeleton;cytosol;Golgi,protein binding;structural molecule activity,"Pf00041, Pf00047, Pf01108, Pf07679, Pf07686, Pf13895, Pf13927",23363,ENSG00000124006.14,OBSL1,2,,,Neddylation,3,High,1
P35270,Sepiapterin reductase OS=Homo sapiens OX=9606 GN=SPR PE=1 SV=1,0,159.924,62,15,305,15,261,28,8.05,153667,5.73,14,2,metabolic process;regulation of biological process,cytoplasm;cytosol,catalytic activity;nucleotide binding,Pf00106,6697,ENSG00000116096.5,SPR,2,Folate biosynthesis; Metabolic pathways,,"eNOS activation and regulation; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation",6,High,1
P05556-5,Isoform 5 of Integrin beta-1 OS=Homo sapiens OX=9606 GN=ITGB1,0,159.797,25,17,619,2,801,88.8,5.48,291120,36.49,14,7,cell differentiation;cell growth;cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;endosome;membrane,metal ion binding;protein binding;receptor activity;signal transducer activity,"Pf00362, Pf07965, Pf08725",3688,ENSG00000150093.18,ITGB1,10,,Integrin-mediated Cell Adhesion; Prolactin Signaling Pathway; Neural Crest Differentiation; Arrhythmogenic Right Ventricular Cardiomyopathy; Pathogenic Escherichia coli infection; Primary Focal Segmental Glomerulosclerosis FSGS; Focal Adhesion; Signaling of Hepatocyte Growth Factor Receptor; Rac1/Pak1/p38/MMP-2 pathway; TGF-beta Signaling Pathway; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; VEGFA-VEGFR2 Signaling Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,,13,High,1
Q9NSD9,Phenylalanine--tRNA ligase beta subunit OS=Homo sapiens OX=9606 GN=FARSB PE=1 SV=3,0,159.742,40,21,340,21,589,66.1,6.84,156325,,21,,cell organization and biogenesis;metabolic process,cytoplasm;cytosol;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding,"Pf03483, Pf03484",10056,ENSG00000116120.9,FARSB,2,Aminoacyl-tRNA biosynthesis,Amino Acid metabolism,Cytosolic tRNA aminoacylation,6,High,1
P46109,Crk-like protein OS=Homo sapiens OX=9606 GN=CRKL PE=1 SV=1,0,159.689,60,18,298,18,303,33.8,6.74,139662,,18,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endosome,protein binding;RNA binding;signal transducer activity,"Pf00017, Pf00018, Pf07653, Pf14604",1399,ENSG00000099942.12,CRKL,22,Fc gamma R-mediated phagocytosis; Renal cell carcinoma; Neurotrophin signaling pathway; Regulation of actin cytoskeleton; ErbB signaling pathway; MicroRNAs in cancer; Chemokine signaling pathway; Rap1 signaling pathway; Bacterial invasion of epithelial cells; Chronic myeloid leukemia; Focal adhesion; Insulin signaling pathway; Pathways in cancer; Shigellosis; MAPK signaling pathway,B Cell Receptor Signaling Pathway; IL-3 Signaling Pathway; Kit receptor signaling pathway; Signaling of Hepatocyte Growth Factor Receptor; MAPK Signaling Pathway; Chemokine signaling pathway; EGF/EGFR Signaling Pathway; IL-2 Signaling Pathway; Interferon type I signaling pathways; T-Cell antigen Receptor (TCR)  Signaling Pathway,MET receptor recycling; Frs2-mediated activation; Regulation of signaling by CBL; MET activates RAP1 and RAC1; Downstream signal transduction,43,High,1
P06756,Integrin alpha-V OS=Homo sapiens OX=9606 GN=ITGAV PE=1 SV=2,0,159.331,28,24,249,24,1048,116,5.68,107175,9.86,24,3,cell differentiation;cell growth;cell organization and biogenesis;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytosol;membrane,metal ion binding;protein binding;receptor activity;signal transducer activity;transporter activity,"Pf01839, Pf08441, Pf13517",3685,ENSG00000138448.11,ITGAV,2,Hypertrophic cardiomyopathy (HCM); Pathways in cancer; Regulation of actin cytoskeleton; Thyroid hormone signaling pathway; Small cell lung cancer; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Phagosome; ECM-receptor interaction; Dilated cardiomyopathy; Focal adhesion; PI3K-Akt signaling pathway; Cell adhesion molecules (CAMs); Proteoglycans in cancer,Osteopontin Signaling; Integrin-mediated Cell Adhesion; Arrhythmogenic Right Ventricular Cardiomyopathy; Primary Focal Segmental Glomerulosclerosis FSGS; Focal Adhesion; Osteoblast Signaling; MFAP5-mediated ovarian cancer cell motility and invasiveness; VEGFA-VEGFR2 Signaling Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,Integrin cell surface interactions; Signal transduction by L1; PECAM1 interactions; Cross-presentation of particulate exogenous antigens (phagosomes); VEGFA-VEGFR2 Pathway; Molecules associated with elastic fibres; Syndecan interactions; ECM proteoglycans; Laminin interactions; Neutrophil degranulation,48,High,1
Q13616,Cullin-1 OS=Homo sapiens OX=9606 GN=CUL1 PE=1 SV=2,0,158.682,41,26,235,26,776,89.6,8,102875,0,26,3,cell death;cell organization and biogenesis;cell proliferation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cytosol,catalytic activity;protein binding,"Pf00888, Pf10557",8454,ENSG00000055130.15,CUL1,7,Oocyte meiosis; Ubiquitin mediated proteolysis; Cell cycle; Hedgehog signaling pathway; Protein processing in endoplasmic reticulum; Herpes simplex infection; Circadian rhythm; Wnt signaling pathway; TGF-beta signaling pathway,TNF alpha Signaling Pathway; Parkin-Ubiquitin Proteasomal System pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; TGF-beta Signaling Pathway; Notch Signaling Pathway,FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; NOTCH1 Intracellular Domain Regulates Transcription; Downstream TCR signaling; Regulation of PLK1 Activity at G2/M Transition; NIK-->noncanonical NF-kB signaling; MAP3K8 (TPL2)-dependent MAPK1/3 activation; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Antigen processing: Ubiquitination & Proteasome degradation; Iron uptake and transport; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; Activated TLR4 signalling; Interleukin-1 family signaling; Degradation of GLI1 by the proteasome; SCF-beta-TrCP mediated degradation of Emi1; Degradation of GLI2 by the proteasome; Regulation of RUNX2 expression and activity; Cyclin D associated events in G1; Prolactin receptor signaling; FCERI mediated NF-kB activation; Neddylation; Circadian Clock; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling; Dectin-1 mediated noncanonical NF-kB signaling,104,High,1
P48444,Coatomer subunit delta OS=Homo sapiens OX=9606 GN=ARCN1 PE=1 SV=1,0,158.599,46,24,316,24,511,57.2,6.21,134641,,24,,response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;Golgi;membrane,RNA binding,Pf00928,372,ENSG00000095139.13,ARCN1,11,,miR-517 relationship with ARCN1 and USP1,COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport,12,High,1
P28161,Glutathione S-transferase Mu 2 OS=Homo sapiens OX=9606 GN=GSTM2 PE=1 SV=2,0,158.138,66,16,716,9,218,25.7,6.37,350980,2.3,16,1,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum,antioxidant activity;catalytic activity;protein binding,"Pf00043, Pf02798, Pf13410, Pf13417, Pf14497",2946,ENSG00000213366.12,GSTM2,1,Chemical carcinogenesis; Metabolism of xenobiotics by cytochrome P450; Platinum drug resistance; Drug metabolism - cytochrome P450; Glutathione metabolism,Glutathione metabolism; NRF2 pathway; Metapathway biotransformation,Glutathione conjugation,12,High,1
P05155,Plasma protease C1 inhibitor OS=Homo sapiens OX=9606 GN=SERPING1 PE=1 SV=2,0,157.816,34,18,533,18,500,55.1,6.55,232745,6.5,18,5,coagulation;defense response;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;organelle lumen,enzyme regulator activity;protein binding,Pf00079,710,ENSG00000149131.15,SERPING1,11,Pertussis; Complement and coagulation cascades,Complement and Coagulation Cascades,Platelet degranulation ; Regulation of Complement cascade; Intrinsic Pathway of Fibrin Clot Formation,13,High,1
Q53GQ0,Very-long-chain 3-oxoacyl-CoA reductase OS=Homo sapiens OX=9606 GN=HSD17B12 PE=1 SV=2,0,157.676,48,14,508,14,312,34.3,9.32,215736,1.6,14,1,cell organization and biogenesis;metabolic process;regulation of biological process,endoplasmic reticulum;membrane,catalytic activity;protein binding,"Pf00106, Pf03435, Pf08659, Pf13460, Pf13561",51144,ENSG00000149084.12,HSD17B12,11,Biosynthesis of unsaturated fatty acids; Steroid hormone biosynthesis; Metabolic pathways; Fatty acid elongation; Fatty acid metabolism,,Androgen biosynthesis; Synthesis of very long-chain fatty acyl-CoAs,13,High,1
P09110,"3-ketoacyl-CoA thiolase, peroxisomal OS=Homo sapiens OX=9606 GN=ACAA1 PE=1 SV=2",0,157.653,42,12,228,12,424,44.3,8.44,111027,6.42,11,1,metabolic process;transport,extracellular;membrane;organelle lumen,catalytic activity;protein binding,"Pf00108, Pf02803, Pf08541",30,ENSG00000060971.17,ACAA1,3,"Metabolic pathways; PPAR signaling pathway; Fatty acid metabolism; alpha-Linolenic acid metabolism; Fatty acid degradation; Valine, leucine and isoleucine degradation; Biosynthesis of unsaturated fatty acids; Peroxisome",PPAR Alpha Pathway; Amino Acid metabolism; PPAR signaling pathway,Neutrophil degranulation; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of very long chain fatty acids,21,High,1
P31943,Heterogeneous nuclear ribonucleoprotein H OS=Homo sapiens OX=9606 GN=HNRNPH1 PE=1 SV=4,0,157.522,46,14,303,9,449,49.2,6.3,159014,0,13,2,metabolic process;regulation of biological process;response to stimulus,cytosol;membrane;nucleus;spliceosomal complex,protein binding;RNA binding,"Pf00076, Pf08080, Pf14259",3187,ENSG00000169045.17; ENSG00000284254.1,HNRNPH1,5; CHR_HG30_PATCH,,Mecp2 and Associated Rett Syndrome; mRNA Processing,mRNA Splicing - Major Pathway; FGFR2 alternative splicing,11,High,1
P51665,26S proteasome non-ATPase regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PSMD7 PE=1 SV=2,0,157.482,41,16,325,16,324,37,6.77,151135,0,16,2,metabolic process;regulation of biological process;response to stimulus;transport,cytosol;extracellular;membrane;nucleus;organelle lumen;proteasome,catalytic activity;protein binding,"Pf01398, Pf13012",5713,ENSG00000103035.10,PSMD7,16,Proteasome; Epstein-Barr virus infection,Proteasome Degradation; Parkin-Ubiquitin Proteasomal System pathway,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Neutrophil degranulation; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,153,High,1
P58107,Epiplakin OS=Homo sapiens OX=9606 GN=EPPK1 PE=1 SV=3,0,157.368,10,13,377,2,5088,555.3,5.62,189422,0,13,1,,,,,,,,,,,,0,High,1
P35443,Thrombospondin-4 OS=Homo sapiens OX=9606 GN=THBS4 PE=1 SV=2,0,157.303,21,19,292,14,961,105.8,4.68,123445,43.86,17,3,cellular component movement;regulation of biological process;response to stimulus,endoplasmic reticulum;extracellular,metal ion binding;protein binding,"Pf02412, Pf05735, Pf07645, Pf11598, Pf12947",7060,ENSG00000113296.14,THBS4,5,Phagosome; Malaria; ECM-receptor interaction; Focal adhesion; PI3K-Akt signaling pathway,Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,Signaling by PDGF,10,High,1
P63244,Receptor of activated protein C kinase 1 OS=Homo sapiens OX=9606 GN=RACK1 PE=1 SV=3,0,157.246,77,18,323,18,317,35.1,7.69,142876,43.16,12,7,cell death;cellular homeostasis;development;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;mitochondrion;nucleus;ribosome,enzyme regulator activity;protein binding;RNA binding;structural molecule activity,Pf00400,10399,ENSG00000204628.11,GNB2L1; RACK1,5,Measles,Androgen receptor signaling pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; VEGFA-VEGFR2 Signaling Pathway; Interferon type I signaling pathways,Regulation of TNFR1 signaling; TNFR1-mediated ceramide production; TNFR1-induced NFkappaB signaling pathway,11,High,1
Q9Y230,RuvB-like 2 OS=Homo sapiens OX=9606 GN=RUVBL2 PE=1 SV=3,0,157.181,46,20,260,20,463,51.1,5.64,120873,0,20,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding,"Pf00004, Pf03796, Pf06068, Pf13481",10856,ENSG00000183207.13,RUVBL2,19,,,HATs acetylate histones; Telomere Extension By Telomerase,8,High,1
Q9Y3F4,Serine-threonine kinase receptor-associated protein OS=Homo sapiens OX=9606 GN=STRAP PE=1 SV=1,0,157.075,54,15,306,15,350,38.4,5.12,141319,2.58,14,1,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,protein binding;RNA binding,Pf00400,11171,ENSG00000023734.10,STRAP,12,RNA transport,TGF-beta Signaling Pathway,Downregulation of TGF-beta receptor signaling,7,High,1
Q96A26,Protein FAM162A OS=Homo sapiens OX=9606 GN=FAM162A PE=1 SV=2,0,156.994,36,11,779,11,154,17.3,9.77,419002,2.1,11,3,cell death;metabolic process;regulation of biological process;response to stimulus,cytosol;membrane;mitochondrion,protein binding,Pf06388,26355,ENSG00000114023.15,FAM162A,3,,,,0,High,1
Q92552,"28S ribosomal protein S27, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS27 PE=1 SV=3",0,156.866,45,17,332,17,414,47.6,6.18,152855,,17,,cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process,cytoplasm;membrane;mitochondrion;ribosome,protein binding;RNA binding,"Pf10037, Pf12854, Pf13041",23107,ENSG00000113048.16,MRPS27,5,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
P16152,Carbonyl reductase [NADPH] 1 OS=Homo sapiens OX=9606 GN=CBR1 PE=1 SV=3,0,156.759,65,15,385,13,277,30.4,8.32,183029,,15,,cell differentiation;metabolic process,cytoplasm;cytosol,catalytic activity,"Pf00106, Pf01370, Pf08659, Pf13561",873; 54093,ENSG00000159228.12,CBR1; SETD4,21,Arachidonic acid metabolism; Chemical carcinogenesis; Metabolism of xenobiotics by cytochrome P450; Metabolic pathways,NRF2 pathway,Synthesis of Prostaglandins (PG) and Thromboxanes (TX),10,High,1
P54646,5'-AMP-activated protein kinase catalytic subunit alpha-2 OS=Homo sapiens OX=9606 GN=PRKAA2 PE=1 SV=2,0,156.669,39,15,237,13,552,62.3,7.75,97219,32.23,14,4,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;Golgi;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf07714, Pf14531",5563,ENSG00000162409.10,PRKAA2,1,Non-alcoholic fatty liver disease (NAFLD); Oxytocin signaling pathway; Hypertrophic cardiomyopathy (HCM); Insulin resistance; AMPK signaling pathway; Insulin signaling pathway; Longevity regulating pathway; Circadian rhythm; mTOR signaling pathway; PI3K-Akt signaling pathway; Glucagon signaling pathway; Adipocytokine signaling pathway; FoxO signaling pathway; Autophagy; Longevity regulating pathway - multiple species,AMP-activated Protein Kinase (AMPK) Signaling; Target Of Rapamycin (TOR) Signaling; Energy Metabolism; Sterol Regulatory Element-Binding Proteins (SREBP) signalling; Leptin signaling pathway; Corticotropin-releasing hormone signaling pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Insulin Signaling,Translocation of GLUT4 to the plasma membrane; Energy dependent regulation of mTOR by LKB1-AMPK; Import of palmitoyl-CoA into the mitochondrial matrix; TP53 Regulates Metabolic Genes; Regulation of TP53 Activity through Phosphorylation; Macroautophagy; AMPK inhibits chREBP transcriptional activation activity; Activation of PPARGC1A (PGC-1alpha) by phosphorylation,50,High,1
P09525,Annexin A4 OS=Homo sapiens OX=9606 GN=ANXA4 PE=1 SV=4,0,156.591,60,21,274,21,319,35.9,6.13,131485,0,21,2,cell differentiation;regulation of biological process;response to stimulus,cell surface;cytoplasm;membrane;nucleus,enzyme regulator activity;metal ion binding;protein binding,Pf00191,307,,ANXA4,2,,Prostaglandin Synthesis and Regulation,,1,High,1
Q07021,"Complement component 1 Q subcomponent-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=C1QBP PE=1 SV=1",0,156.462,41,15,492,15,282,31.3,4.84,255427,48.08,14,1,cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,cell surface;cytoplasm;cytosol;extracellular;membrane;mitochondrion;nucleus;organelle lumen,protein binding;RNA binding,Pf02330,708,ENSG00000108561.8,C1QBP,17,Herpes simplex infection,Mesodermal Commitment Pathway,Intrinsic Pathway of Fibrin Clot Formation,5,High,1
Q13838,Spliceosome RNA helicase DDX39B OS=Homo sapiens OX=9606 GN=DDX39B PE=1 SV=1,0,156.365,45,20,399,7,428,49,5.67,186953,0,20,3,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;nucleus;spliceosomal complex,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00270, Pf00271, Pf14617",7919,ENSG00000225859.10; ENSG00000215425.11; ENSG00000198563.13; ENSG00000235439.10; ENSG00000230624.10; ENSG00000225073.10; ENSG00000229496.10,DDX39B,6; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_MCF_CTG1,mRNA surveillance pathway; Influenza A; Spliceosome; RNA transport,,Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing,13,High,1
P19429,"Troponin I, cardiac muscle OS=Homo sapiens OX=9606 GN=TNNI3 PE=1 SV=3",0,156.281,51,14,5989,12,210,24,9.86,2918216,344.03,9,9,cell differentiation;cellular component movement;cellular homeostasis;regulation of biological process;response to stimulus,cytoplasm;cytosol,metal ion binding;protein binding,Pf00992,7137,ENSG00000129991.12,TNNI3,19,cAMP signaling pathway; Dilated cardiomyopathy; Hypertrophic cardiomyopathy (HCM); Adrenergic signaling in cardiomyocytes; Cardiac muscle contraction,Cardiac Progenitor Differentiation; Striated Muscle Contraction,Ion homeostasis; Striated Muscle Contraction,11,High,1
Q6ICL3,Transport and Golgi organization protein 2 homolog OS=Homo sapiens OX=9606 GN=TANGO2 PE=1 SV=1,0,155.98,66,16,254,16,276,30.9,5.17,110341,30.58,16,2,,Golgi,,Pf05742,128989,ENSG00000183597.15,C22orf25; TANGO2,22,,,,0,High,1
P54727,UV excision repair protein RAD23 homolog B OS=Homo sapiens OX=9606 GN=RAD23B PE=1 SV=1,0,155.61,43,16,281,13,409,43.1,4.84,142955,0,16,2,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus;proteasome,DNA binding;protein binding,"Pf00240, Pf00627, Pf09280, Pf11976, Pf13881",5887,ENSG00000119318.12,RAD23B,9,Nucleotide excision repair; Protein processing in endoplasmic reticulum,,Josephin domain DUBs; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; N-glycan trimming in the ER and Calnexin/Calreticulin cycle,13,High,1
Q96CN7,Isochorismatase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ISOC1 PE=1 SV=3,0,155.447,49,12,383,12,298,32.2,7.39,168356,,12,,metabolic process,cytoplasm,catalytic activity;protein binding,Pf00857,51015,ENSG00000066583.11,ISOC1,5,,,,0,High,1
P62820,Ras-related protein Rab-1A OS=Homo sapiens OX=9606 GN=RAB1A PE=1 SV=3,0,155.307,66,15,485,6,205,22.7,6.21,234648,1.7,15,1,cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;endosome;Golgi;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00009, Pf00025, Pf00071, Pf01926, Pf04670, Pf08477, Pf09439",5861,ENSG00000138069.16,RAB1A,2,Legionellosis,,COPI-dependent Golgi-to-ER retrograde traffic; COPII (Coat Protein 2) Mediated Vesicle Transport; COPI-mediated anterograde transport; Golgi Cisternae Pericentriolar Stack Reorganization; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation,21,High,1
Q06033,Inter-alpha-trypsin inhibitor heavy chain H3 OS=Homo sapiens OX=9606 GN=ITIH3 PE=1 SV=2,0,154.991,30,21,182,21,890,99.8,5.74,76257,4.76,21,2,metabolic process;regulation of biological process;transport,extracellular;organelle lumen,enzyme regulator activity,"Pf00092, Pf06668, Pf08487, Pf11443, Pf13519, Pf13768",3699,ENSG00000162267.12,ITIH3,3,,,Platelet degranulation,4,High,1
P22694,cAMP-dependent protein kinase catalytic subunit beta OS=Homo sapiens OX=9606 GN=PRKACB PE=1 SV=2,0,154.953,40,14,609,5,351,40.6,8.78,278861,0,14,1,cell organization and biogenesis;coagulation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf07714, Pf14531",5567,ENSG00000142875.19,PRKACB,1,Viral carcinogenesis; Bile secretion; Pathways in cancer; Melanogenesis; GABAergic synapse; Cholinergic synapse; Insulin signaling pathway; Circadian entrainment; Glucagon signaling pathway; Vasopressin-regulated water reabsorption; cAMP signaling pathway; Prion diseases; MAPK signaling pathway; Gap junction; Retrograde endocannabinoid signaling; Endocrine resistance; Serotonergic synapse; Renin secretion; Long-term potentiation; Parkinson's disease; Inflammatory mediator regulation of TRP channels; Calcium signaling pathway; Dilated cardiomyopathy; Endocrine and other factor-regulated calcium reabsorption; Thyroid hormone synthesis; Gastric acid secretion; Estrogen signaling pathway; Glutamatergic synapse; Oxytocin signaling pathway; Taste transduction; Cocaine addiction; GnRH signaling pathway; Amoebiasis; Epstein-Barr virus infection; Insulin secretion; Aldosterone synthesis and secretion; Vibrio cholerae infection; Platelet activation; Dopaminergic synapse; Wnt signaling pathway; HTLV-I infection; Adrenergic signaling in cardiomyocytes; Thyroid hormone signaling pathway; Longevity regulating pathway; Morphine addiction; Regulation of lipolysis in adipocytes; Olfactory transduction; Chemokine signaling pathway; Progesterone-mediated oocyte maturation; Ras signaling pathway; Amphetamine addiction; Salivary secretion; Ovarian steroidogenesis; Hedgehog signaling pathway; Vascular smooth muscle contraction; Oocyte meiosis; Longevity regulating pathway - multiple species; Proteoglycans in cancer,AMP-activated Protein Kinase (AMPK) Signaling; miRs in Muscle Cell Differentiation; Dopamine metabolism; Common Pathways Underlying Drug Addiction; Myometrial Relaxation and Contraction Pathways; G Protein Signaling Pathways; Chemokine signaling pathway; Calcium Regulation in the Cardiac Cell; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,Triglyceride catabolism; Glycolysis; ROBO receptors bind AKAP5; HDL assembly; GLI3 is processed to GLI3R by the proteasome; Vasopressin regulates renal water homeostasis via Aquaporins; Factors involved in megakaryocyte development and platelet production; Signaling by GPCR; Rap1 signalling; Degradation of GLI1 by the proteasome; PKA activation in glucagon signalling; Degradation of GLI2 by the proteasome; CREB phosphorylation through the activation of Adenylate Cyclase; DARPP-32 events; VEGFA-VEGFR2 Pathway; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; CD209 (DC-SIGN) signaling; PKA-mediated phosphorylation of key metabolic factors; PKA activation; RET signaling; MAPK6/MAPK4 signaling,128,High,1
Q4G176,"Malonate--CoA ligase ACSF3, mitochondrial OS=Homo sapiens OX=9606 GN=ACSF3 PE=1 SV=3",0,154.728,38,19,264,19,576,64.1,8.37,124605,16.19,18,2,metabolic process,mitochondrion;organelle lumen,catalytic activity;nucleotide binding,"Pf00501, Pf13193",197322,ENSG00000176715.15,ACSF3,16,"Valine, leucine and isoleucine degradation",,Synthesis of very long-chain fatty acyl-CoAs,6,High,1
O14617,AP-3 complex subunit delta-1 OS=Homo sapiens OX=9606 GN=AP3D1 PE=1 SV=1,0,154.66,29,26,135,26,1153,130.1,8.48,57916,,26,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport,cytoplasm;Golgi;membrane,transporter activity,"Pf01602, Pf06375",8943,ENSG00000065000.15,AP3D1,19,Lysosome,,,1,High,1
O43396,Thioredoxin-like protein 1 OS=Homo sapiens OX=9606 GN=TXNL1 PE=1 SV=3,0,154.602,59,13,244,13,289,32.2,4.96,124773,0,13,2,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus;proteasome,antioxidant activity;catalytic activity,"Pf00085, Pf06201, Pf13098",9352,ENSG00000091164.12,TXNL1,18,,,,0,High,1
Q92973,Transportin-1 OS=Homo sapiens OX=9606 GN=TNPO1 PE=1 SV=2,0,154.597,24,20,359,14,898,102.3,4.98,152642,0,20,3,cellular component movement;regulation of biological process;transport,cytoplasm;cytosol;membrane;nucleus,protein binding;RNA binding;transporter activity,"Pf03810, Pf13513, Pf13646",3842,ENSG00000083312.17,TNPO1,5,,,"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Intraflagellar transport",6,High,1
O75367-2,Isoform 1 of Core histone macro-H2A.1 OS=Homo sapiens OX=9606 GN=H2AFY,0,154.276,54,15,584,12,369,39.2,9.83,251290,13.72,13,3,cell organization and biogenesis;regulation of biological process,chromosome;nucleus,DNA binding;enzyme regulator activity;protein binding,"Pf00125, Pf01661",9555,ENSG00000113648.16,H2AFY,5,,H19 action Rb-E2F1 signaling and CDK-beta-catenin activity,,1,High,1
P26639,"Threonine--tRNA ligase 1, cytoplasmic OS=Homo sapiens OX=9606 GN=TARS1 PE=1 SV=3",0,154.17,33,27,230,24,723,83.4,6.67,96805,2.17,27,4,metabolic process,cytoplasm;cytoskeleton;cytosol,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00587, Pf02824, Pf03129, Pf07973",6897,ENSG00000113407.13,TARS,5,Aminoacyl-tRNA biosynthesis,,Cytosolic tRNA aminoacylation,5,High,1
Q3LXA3,Triokinase/FMN cyclase OS=Homo sapiens OX=9606 GN=TKFC PE=1 SV=2,0,154.127,39,16,183,16,575,58.9,7.49,83013,,16,,defense response;metabolic process;regulation of biological process;response to stimulus,cytosol;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf02733, Pf02734",26007,ENSG00000149476.15,DAK; TKFC,11,RIG-I-like receptor signaling pathway; Carbon metabolism; Fructose and mannose metabolism; Metabolic pathways; Glycerolipid metabolism,RIG-I-like Receptor Signaling,Fructose catabolism; DDX58/IFIH1-mediated induction of interferon-alpha/beta,13,High,1
P13674,Prolyl 4-hydroxylase subunit alpha-1 OS=Homo sapiens OX=9606 GN=P4HA1 PE=1 SV=2,0,154.065,49,19,141,19,534,61,6.01,56465,0,19,1,cell organization and biogenesis;metabolic process,endoplasmic reticulum;membrane;mitochondrion;organelle lumen,catalytic activity;metal ion binding;protein binding,"Pf03171, Pf08336",5033,ENSG00000122884.12,P4HA1,10,Metabolic pathways; Arginine and proline metabolism,,Collagen biosynthesis and modifying enzymes,5,High,1
P11717,Cation-independent mannose-6-phosphate receptor OS=Homo sapiens OX=9606 GN=IGF2R PE=1 SV=3,0,154.031,14,28,147,28,2491,274.2,5.94,65961,,28,,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;endosome;Golgi;membrane;nucleus;vacuole,catalytic activity;protein binding;receptor activity;signal transducer activity;transporter activity,"Pf00040, Pf00878, Pf02157, Pf09451",3482,ENSG00000197081.12,IGF2R,6,Endocytosis; Lysosome,,Cargo recognition for clathrin-mediated endocytosis; Retrograde transport at the Trans-Golgi-Network; Neutrophil degranulation; Golgi Associated Vesicle Biogenesis,14,High,1
P28066,Proteasome subunit alpha type-5 OS=Homo sapiens OX=9606 GN=PSMA5 PE=1 SV=3,0,153.826,58,13,259,13,241,26.4,4.79,136694,22.93,11,3,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;nucleus;organelle lumen;proteasome,catalytic activity;nucleotide binding;protein binding,"Pf00227, Pf10584",5686,ENSG00000143106.12,PSMA5,1,Proteasome,Proteasome Degradation,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Neutrophil degranulation; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,151,High,1
P13798,Acylamino-acid-releasing enzyme OS=Homo sapiens OX=9606 GN=APEH PE=1 SV=4,0,153.778,36,18,237,18,732,81.2,5.48,104598,0,18,1,cell organization and biogenesis;metabolic process;transport,cytoplasm;cytosol;extracellular;membrane,catalytic activity;protein binding;RNA binding,"Pf00326, Pf00561, Pf01738, Pf02230, Pf05448, Pf12695, Pf12697",327,ENSG00000164062.12,APEH,3,,,Eukaryotic Translation Termination; Neutrophil degranulation,6,High,1
O75122,CLIP-associating protein 2 OS=Homo sapiens OX=9606 GN=CLASP2 PE=1 SV=3,0,153.652,25,26,164,1,1294,141,8.4,67776,0,26,1,,,,,,,,,,,,0,High,1
Q14157,Ubiquitin-associated protein 2-like OS=Homo sapiens OX=9606 GN=UBAP2L PE=1 SV=2,0,153.135,29,18,119,18,1087,114.5,7.11,57204,,18,,regulation of biological process,cytoplasm,protein binding;RNA binding,"Pf00627, Pf12478, Pf14555",9898,ENSG00000143569.18,UBAP2L,1,,,,0,High,1
P28482,Mitogen-activated protein kinase 1 OS=Homo sapiens OX=9606 GN=MAPK1 PE=1 SV=3,0,153.026,48,17,231,13,360,41.4,6.98,105257,0,17,1,cell communication;cell death;cell differentiation;cell proliferation;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endosome;extracellular;Golgi;membrane;mitochondrion;nucleus;organelle lumen,catalytic activity;DNA binding;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf01636, Pf07714",5594,ENSG00000100030.14,MAPK1,22,TGF-beta signaling pathway; Insulin signaling pathway; B cell receptor signaling pathway; Breast cancer; Gap junction; Focal adhesion; Oocyte meiosis; Endocrine resistance; Shigellosis; Chagas disease (American trypanosomiasis); Vascular smooth muscle contraction; cGMP-PKG signaling pathway; Oxytocin signaling pathway; Long-term potentiation; Toxoplasmosis; Long-term depression; Alcoholism; Cholinergic synapse; NOD-like receptor signaling pathway; Prolactin signaling pathway; Non-small cell lung cancer; ErbB signaling pathway; Pertussis; Aldosterone-regulated sodium reabsorption; Fc epsilon RI signaling pathway; cAMP signaling pathway; T cell receptor signaling pathway; Central carbon metabolism in cancer; Leishmaniasis; Colorectal cancer; AGE-RAGE signaling pathway in diabetic complications; Choline metabolism in cancer; Sphingolipid signaling pathway; Chemokine signaling pathway; Serotonergic synapse; Hepatitis B; Neurotrophin signaling pathway; Circadian entrainment; Glioma; Melanogenesis; Regulation of actin cytoskeleton; Fc gamma R-mediated phagocytosis; Platelet activation; Prion diseases; Phospholipase D signaling pathway; Progesterone-mediated oocyte maturation; Prostate cancer; EGFR tyrosine kinase inhibitor resistance; Salmonella infection; Hepatitis C; Estrogen signaling pathway; TNF signaling pathway; FoxO signaling pathway; Acute myeloid leukemia; Natural killer cell mediated cytotoxicity; Tuberculosis; Alzheimer's disease; Bladder cancer; Signaling pathways regulating pluripotency of stem cells; HIF-1 signaling pathway; Adrenergic signaling in cardiomyocytes; GnRH signaling pathway; Glutamatergic synapse; Thyroid hormone signaling pathway; Ras signaling pathway; Osteoclast differentiation; Pathways in cancer; Thyroid cancer; Dorso-ventral axis formation; Type II diabetes mellitus; Toll-like receptor signaling pathway; Th1 and Th2 cell differentiation; Endometrial cancer; Retrograde endocannabinoid signaling; Viral carcinogenesis; MAPK signaling pathway; Adherens junction; Rap1 signaling pathway; mTOR signaling pathway; VEGF signaling pathway; Proteoglycans in cancer; Platinum drug resistance; Chronic myeloid leukemia; Apoptosis; PI3K-Akt signaling pathway; MicroRNAs in cancer; Melanoma; Influenza A; Pancreatic cancer; Renal cell carcinoma; Axon guidance,"IL-5 Signaling Pathway; Osteopontin Signaling; Regulation of toll-like receptor signaling pathway; Physiological and Pathological Hypertrophy  of the Heart; Angiogenesis; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; Heart Development; Integrin-mediated Cell Adhesion; IL-1 signaling pathway; Integrated Breast Cancer Pathway; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; Human Thyroid Stimulating Hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle Stimulating Hormone (FSH) signaling pathway; TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway; Prolactin Signaling Pathway; IL-7 Signaling Pathway; Alzheimers Disease; IL17 signaling pathway; Endothelin Pathways; IL-9 Signaling Pathway; Signaling Pathways in Glioblastoma; B Cell Receptor Signaling Pathway; TNF alpha Signaling Pathway; AGE/RAGE pathway; Interleukin-11 Signaling Pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Spinal Cord Injury; Alpha 6 Beta 4 signaling pathway; PDGF Pathway; Aryl Hydrocarbon Receptor; Signal Transduction of S1P Receptor; EBV LMP1 signaling; Common Pathways Underlying Drug Addiction; Structural Pathway of Interleukin 1 (IL-1); Cardiac Hypertrophic Response; Bladder Cancer; IL-3 Signaling Pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer; Kit receptor signaling pathway; Focal Adhesion; Signaling of Hepatocyte Growth Factor Receptor; MFAP5-mediated ovarian cancer cell motility and invasiveness; Rac1/Pak1/p38/MMP-2 pathway; Wnt Signaling Pathway Netpath; IL-6 signaling pathway; TGF-beta Signaling Pathway; Hypothesized Pathways in Pathogenesis of Cardiovascular Disease; BDNF-TrkB Signaling; Association Between Physico-Chemical Features and Toxicity Associated Pathways; MAPK Signaling Pathway; MAPK  and NFkB Signalling Pathways Inhibited by Yersinia YopJ; ERK Pathway in Huntington's Disease; Toll-like Receptor Signaling; TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition; 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; Chemokine signaling pathway; ESC Pluripotency Pathways; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; IL-4 Signaling Pathway; MAPK Cascade; EGF/EGFR Signaling Pathway; Insulin Signaling; IL-2 Signaling Pathway; Regulation of Actin Cytoskeleton; EPO Receptor Signaling; Senescence and Autophagy in Cancer; ErbB Signaling Pathway; T-Cell antigen Receptor (TCR)  Signaling Pathway; DNA Damage Response (only ATM dependent); Estrogen signaling pathway; Vitamin A and Carotenoid Metabolism; Toll-like receptor signaling pathway","phospho-PLA2 pathway; NCAM signaling for neurite out-growth; Activated TLR4 signalling; Negative feedback regulation of MAPK pathway; RUNX2 regulates osteoblast differentiation; Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; Signaling by BRAF and RAF fusions; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; RSK activation; ERKs are inactivated; MAP2K and MAPK activation; FCERI mediated MAPK activation; Signaling by GPCR; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signal attenuation; Activation of the AP-1 family of transcription factors; Golgi Cisternae Pericentriolar Stack Reorganization; MAPK1 (ERK2) activation; Interleukin-20 family signaling; Spry regulation of FGF signaling; Signal transduction by L1; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Regulation of HSF1-mediated heat shock response; Advanced glycosylation endproduct receptor signaling; Recycling pathway of L1; Thrombin signalling through proteinase activated receptors (PARs); Gastrin-CREB signalling pathway via PKC and MAPK; Regulation of PTEN gene transcription; RHO GTPases Activate WASPs and WAVEs; Oncogene Induced Senescence; Growth hormone receptor signaling; Senescence-Associated Secretory Phenotype (SASP); Oxidative Stress Induced Senescence",290,High,1
P07686,Beta-hexosaminidase subunit beta OS=Homo sapiens OX=9606 GN=HEXB PE=1 SV=3,0,152.885,32,17,224,16,556,63.1,6.76,109252,0,17,2,cell organization and biogenesis;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;reproduction;response to stimulus;transport,extracellular;membrane;organelle lumen;vacuole,catalytic activity;protein binding,"Pf00728, Pf14845",3074,,HEXB,5,Other glycan degradation; Glycosphingolipid biosynthesis - ganglio series; Glycosphingolipid biosynthesis - globo and isoglobo series; Amino sugar and nucleotide sugar metabolism; Lysosome; Metabolic pathways; Glycosaminoglycan degradation,,Neutrophil degranulation; CS/DS degradation; Glycosphingolipid metabolism; Hyaluronan uptake and degradation; Keratan sulfate degradation,22,High,1
P37802,Transgelin-2 OS=Homo sapiens OX=9606 GN=TAGLN2 PE=1 SV=3,0,152.438,64,13,611,13,199,22.4,8.25,294333,0,13,3,cell differentiation;transport,cytosol;extracellular,protein binding,"Pf00307, Pf00402",8407,ENSG00000158710.14,TAGLN2,1,,,Platelet degranulation,4,High,1
O43795,Unconventional myosin-Ib OS=Homo sapiens OX=9606 GN=MYO1B PE=1 SV=3,0,152.387,27,29,218,1,1136,131.9,9.38,89754,0,29,1,cell organization and biogenesis;cellular component movement;transport,cytoplasm;endosome;membrane,catalytic activity;motor activity;nucleotide binding;protein binding,"Pf00063, Pf06017",4430,ENSG00000128641.18,MYO1B,2,,,,0,High,1
O95373,Importin-7 OS=Homo sapiens OX=9606 GN=IPO7 PE=1 SV=1,0,152.331,24,19,214,19,1038,119.4,4.82,99555,0,19,1,defense response;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus,enzyme regulator activity;protein binding;transporter activity,"Pf03810, Pf08506",10527,ENSG00000205339.9,IPO7,11,,,,0,High,1
Q7L0Y3,tRNA methyltransferase 10 homolog C OS=Homo sapiens OX=9606 GN=TRMT10C PE=1 SV=2,0,152.172,48,17,213,17,403,47.3,9.36,94560,0,17,1,cell organization and biogenesis;metabolic process;regulation of biological process,mitochondrion;organelle lumen,catalytic activity;protein binding;RNA binding,Pf01746,54931,ENSG00000174173.6,TRMT10C,3,,,tRNA processing in the mitochondrion; rRNA processing in the mitochondrion; tRNA modification in the mitochondrion,6,High,1
P47756,F-actin-capping protein subunit beta OS=Homo sapiens OX=9606 GN=CAPZB PE=1 SV=4,0,152.083,49,14,519,14,277,31.3,5.59,245450,26.51,12,6,cell organization and biogenesis;cellular component movement;coagulation;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol,protein binding,Pf01115,832,ENSG00000077549.17,CAPZB,1,Endocytosis,,COPI-independent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR); Factors involved in megakaryocyte development and platelet production,20,High,1
P63241,Eukaryotic translation initiation factor 5A-1 OS=Homo sapiens OX=9606 GN=EIF5A PE=1 SV=2,0,151.98,56,11,515,6,154,16.8,5.24,269833,9.88,10,2,cell death;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus,protein binding;RNA binding,Pf01287,1984,ENSG00000132507.17,EIF5A,17,,Translation Factors; eIF5A regulation in response to inhibition of the nuclear export system,Hypusine synthesis from eIF5A-lysine,6,High,1
P02649,Apolipoprotein E OS=Homo sapiens OX=9606 GN=APOE PE=1 SV=1,0,151.778,56,16,280,16,317,36.1,5.73,141479,0,16,2,cell communication;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;endosome;extracellular;Golgi;membrane;nucleus;organelle lumen,antioxidant activity;catalytic activity;enzyme regulator activity;metal ion binding;protein binding;structural molecule activity;transporter activity,Pf01442,348,ENSG00000130203.9,APOE,19,Alzheimer's disease,Vitamin B12 Metabolism; Alzheimers Disease; Apoptosis-related network due to altered Notch3 in ovarian cancer; ApoE and miR-146 in inflammation and atherosclerosis; Statin Pathway,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Retinoid metabolism and transport; Chylomicron remodeling; Scavenging by Class A Receptors; Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors; Signaling by GPCR; HDL remodeling; Chylomicron assembly; Chylomicron clearance,33,High,1
Q8NE71,ATP-binding cassette sub-family F member 1 OS=Homo sapiens OX=9606 GN=ABCF1 PE=1 SV=2,0,151.706,33,23,126,23,845,95.9,6.8,56898,7.45,22,3,defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus;ribosome,catalytic activity;nucleotide binding;protein binding;RNA binding;translation regulator activity,"Pf00005, Pf13304",23,ENSG00000225989.9; ENSG00000232169.9; ENSG00000204574.12; ENSG00000206490.11; ENSG00000236149.9; ENSG00000236342.8; ENSG00000231129.8,ABCF1,6; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_MANN_CTG1,,,ABC-family proteins mediated transport,2,High,1
P51858,Hepatoma-derived growth factor OS=Homo sapiens OX=9606 GN=HDGF PE=1 SV=1,0,151.66,63,16,195,14,240,26.8,4.73,97668,16.28,13,4,cell proliferation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;extracellular;nucleus,DNA binding;nucleotide binding;protein binding;RNA binding,Pf00855,3068,ENSG00000143321.18,HDGF,1,,,XBP1(S) activates chaperone genes,4,High,1
Q9UHD8,Septin-9 OS=Homo sapiens OX=9606 GN=SEPTIN9 PE=1 SV=2,0,151.507,43,20,280,19,586,65.4,8.97,140337,,20,,cell division;cell organization and biogenesis;regulation of biological process,cytoplasm;cytoskeleton,catalytic activity;nucleotide binding;protein binding,"Pf00735, Pf01926, Pf03193, Pf04548",10801,ENSG00000184640.17,SEPT9,17,Bacterial invasion of epithelial cells,,,1,High,1
O75122-3,Isoform 3 of CLIP-associating protein 2 OS=Homo sapiens OX=9606 GN=CLASP2,0,151.231,22,27,163,2,1515,165.8,8.31,65940,4.93,25,3,,,,,,,,,,,,0,High,1
P34949,Mannose-6-phosphate isomerase OS=Homo sapiens OX=9606 GN=MPI PE=1 SV=2,0,151.179,44,12,314,12,423,46.6,5.95,150651,7.32,11,1,metabolic process,cytoplasm;cytosol,catalytic activity;metal ion binding,Pf01238,4351,ENSG00000178802.17,MPI,15,Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Fructose and mannose metabolism,,Synthesis of GDP-mannose; Defective MPI causes MPI-CDG (CDG-1b),13,High,1
Q9BQ95,"Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial OS=Homo sapiens OX=9606 GN=ECSIT PE=1 SV=1",0,151.129,59,18,274,18,431,49.1,6.29,118648,2.36,15,4,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;mitochondrion;nucleus,catalytic activity;protein binding,"Pf06239, Pf14784",51295,ENSG00000130159.13,ECSIT,19,MAPK signaling pathway,IL-1 signaling pathway; Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway; MAPK Signaling Pathway,MyD88:Mal cascade initiated on plasma membrane; MyD88 cascade initiated on plasma membrane; Complex I biogenesis; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation; Activated TLR4 signalling,25,High,1
Q6IBS0,Twinfilin-2 OS=Homo sapiens OX=9606 GN=TWF2 PE=1 SV=2,0,151.088,55,16,185,14,349,39.5,6.84,83248,,16,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton,nucleotide binding;protein binding;RNA binding,Pf00241,11344,ENSG00000247596.8,TWF2,3,,,,0,High,1
P61604,"10 kDa heat shock protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPE1 PE=1 SV=2",0,151.024,89,22,1450,22,102,10.9,8.92,763133,,22,,cell differentiation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;membrane;mitochondrion;organelle lumen,metal ion binding;nucleotide binding;protein binding;RNA binding,Pf00166,3336,ENSG00000115541.10,HSPE1,2,,,,0,High,1
Q9NQW7-3,Isoform 3 of Xaa-Pro aminopeptidase 1 OS=Homo sapiens OX=9606 GN=XPNPEP1,0,151.006,35,16,299,16,666,74.8,5.88,134623,10.62,15,3,metabolic process,cytoplasm;cytosol,catalytic activity;metal ion binding;protein binding,"Pf00557, Pf01321",7511,ENSG00000108039.17,XPNPEP1,10,,,,0,High,1
O43795-2,Isoform 2 of Unconventional myosin-Ib OS=Homo sapiens OX=9606 GN=MYO1B,0,150.979,28,29,216,1,1078,124.9,9.2,88069,11.19,28,2,cell organization and biogenesis;cellular component movement;transport,cytoplasm;endosome;membrane,catalytic activity;motor activity;nucleotide binding;protein binding,"Pf00063, Pf06017",4430,ENSG00000128641.18,MYO1B,2,,,,0,High,1
P42330,Aldo-keto reductase family 1 member C3 OS=Homo sapiens OX=9606 GN=AKR1C3 PE=1 SV=4,0,150.569,56,16,188,13,323,36.8,7.94,90242,0,16,1,cell communication;cell differentiation;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus,catalytic activity,Pf00248,8644,ENSG00000196139.13,AKR1C3,10,Metabolic pathways; Steroid hormone biosynthesis; Ovarian steroidogenesis; Arachidonic acid metabolism,Benzo(a)pyrene metabolism; Metapathway biotransformation,Signaling by GPCR; RA biosynthesis pathway; Retinoid metabolism and transport; Synthesis of bile acids and bile salts via 27-hydroxycholesterol; Synthesis of bile acids and bile salts via 24-hydroxycholesterol; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Synthesis of Prostaglandins (PG) and Thromboxanes (TX),26,High,1
P04080,Cystatin-B OS=Homo sapiens OX=9606 GN=CSTB PE=1 SV=2,0,150.47,70,10,364,10,98,11.1,7.56,177299,41.09,10,3,regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;nucleus;organelle lumen,enzyme regulator activity;protein binding;RNA binding,Pf00031,1476,ENSG00000160213.6,CSTB,21,,,Neutrophil degranulation,3,High,1
O15294,UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Homo sapiens OX=9606 GN=OGT PE=1 SV=3,0,150.408,28,26,159,26,1046,116.9,6.7,64340,0,26,2,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;mitochondrion;nucleus,catalytic activity;protein binding,"Pf00515, Pf04184, Pf07719, Pf13176, Pf13181, Pf13374, Pf13414, Pf13424, Pf13428, Pf13429, Pf13431, Pf13432, Pf13844, Pf14559",8473,ENSG00000147162.13,OGT,X,Other types of O-glycan biosynthesis; Insulin resistance,Ectoderm Differentiation,HATs acetylate histones; UCH proteinases,10,High,1
Q9BPW8,Protein NipSnap homolog 1 OS=Homo sapiens OX=9606 GN=NIPSNAP1 PE=1 SV=1,0,150.371,43,12,286,10,284,33.3,9.31,127524,,12,,,membrane;mitochondrion,protein binding,Pf07978,8508,ENSG00000184117.11,NIPSNAP1,22,,,,0,High,1
P28074,Proteasome subunit beta type-5 OS=Homo sapiens OX=9606 GN=PSMB5 PE=1 SV=3,0,150.164,56,15,219,14,263,28.5,6.92,114108,5.52,14,2,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus;proteasome,catalytic activity;protein binding,Pf00227,5693,ENSG00000100804.18,PSMB5,14,Proteasome,Proteasome Degradation,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,150,High,1
P36507,Dual specificity mitogen-activated protein kinase kinase 2 OS=Homo sapiens OX=9606 GN=MAP2K2 PE=1 SV=1,0,150.069,58,18,430,12,400,44.4,6.55,182326,2.78,17,1,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;endosome;extracellular;Golgi;membrane;mitochondrion;nucleus,catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf07714, Pf14531",5605,ENSG00000126934.13,MAP2K2,19,T cell receptor signaling pathway; Acute myeloid leukemia; Melanoma; GnRH signaling pathway; cGMP-PKG signaling pathway; Long-term potentiation; Bladder cancer; FoxO signaling pathway; Natural killer cell mediated cytotoxicity; Long-term depression; Vascular smooth muscle contraction; Non-small cell lung cancer; Apoptosis; cAMP signaling pathway; B cell receptor signaling pathway; Gap junction; Ras signaling pathway; MicroRNAs in cancer; Pathways in cancer; Sphingolipid signaling pathway; HIF-1 signaling pathway; Endometrial cancer; Choline metabolism in cancer; PI3K-Akt signaling pathway; Chronic myeloid leukemia; Thyroid hormone signaling pathway; Fc epsilon RI signaling pathway; Hepatitis B; MAPK signaling pathway; Melanogenesis; Influenza A; Phospholipase D signaling pathway; Prostate cancer; Toll-like receptor signaling pathway; Prion diseases; Rap1 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Signaling pathways regulating pluripotency of stem cells; Prolactin signaling pathway; ErbB signaling pathway; Regulation of actin cytoskeleton; VEGF signaling pathway; Renal cell carcinoma; Endocrine resistance; Central carbon metabolism in cancer; Breast cancer; mTOR signaling pathway; Neurotrophin signaling pathway; Glioma; Thyroid cancer; Insulin signaling pathway; Oxytocin signaling pathway; Proteoglycans in cancer; Estrogen signaling pathway,"IL-5 Signaling Pathway; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated Cell Adhesion; IL-1 signaling pathway; Leptin signaling pathway; Prolactin Signaling Pathway; IL-7 Signaling Pathway; IL-9 Signaling Pathway; Signaling Pathways in Glioblastoma; B Cell Receptor Signaling Pathway; Interleukin-11 Signaling Pathway; Oncostatin M Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Amyotrophic lateral sclerosis (ALS); Common Pathways Underlying Drug Addiction; Structural Pathway of Interleukin 1 (IL-1); Cardiac Hypertrophic Response; Bladder Cancer; Kit receptor signaling pathway; Focal Adhesion; Signaling of Hepatocyte Growth Factor Receptor; IL-6 signaling pathway; Pathways Affected in Adenoid Cystic Carcinoma; TGF-beta Signaling Pathway; MAPK Signaling Pathway; T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; ESC Pluripotency Pathways; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; MAPK Cascade; EGF/EGFR Signaling Pathway; Insulin Signaling; IL-2 Signaling Pathway; Regulation of Actin Cytoskeleton; EPO Receptor Signaling; T-Cell antigen Receptor (TCR)  Signaling Pathway; Serotonin Receptor 2 and ELK-SRF/GATA4 signaling; Serotonin Receptor 4/6/7 and NR3C Signaling; Toll-like receptor signaling pathway",Signaling by BRAF and RAF fusions; Signal transduction by L1; MAP2K and MAPK activation; Uptake and function of anthrax toxins; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; Negative feedback regulation of MAPK pathway; Paradoxical activation of RAF signaling by kinase inactive BRAF; RAF activation; MAPK1 (ERK2) activation; Interleukin-20 family signaling,125,High,1
Q9Y2P4,Long-chain fatty acid transport protein 6 OS=Homo sapiens OX=9606 GN=SLC27A6 PE=2 SV=1,0,150.033,29,20,370,20,619,70.1,8.51,161436,2.57,19,4,metabolic process;transport,membrane,catalytic activity;nucleotide binding;transporter activity,"Pf00501, Pf13193",28965,ENSG00000113396.12,SLC27A6,5,PPAR signaling pathway; Insulin resistance,PPAR signaling pathway,Transport of fatty acids,7,High,1
P51608-2,Isoform B of Methyl-CpG-binding protein 2 OS=Homo sapiens OX=9606 GN=MECP2,0,150.007,42,19,217,19,498,53.3,9.88,84580,21.47,17,3,cell communication;cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;mitochondrion;nucleus,DNA binding;nucleotide binding;protein binding;RNA binding,Pf01429,4204,ENSG00000169057.21,MECP2,X,,Ectoderm Differentiation; Mecp2 and Associated Rett Syndrome; Lung fibrosis; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,,4,High,1
Q8N3L3,Beta-taxilin OS=Homo sapiens OX=9606 GN=TXLNB PE=1 SV=3,0,149.738,36,18,114,18,684,76.5,4.93,38327,78.51,11,11,,cytoplasm,protein binding,Pf09728,167838,ENSG00000164440.14,TXLNB,6,,,,0,High,1
P07108,Acyl-CoA-binding protein OS=Homo sapiens OX=9606 GN=DBI PE=1 SV=2,0,149.435,59,8,785,8,87,10,6.57,353014,6.82,8,2,metabolic process;transport,endoplasmic reticulum;Golgi;organelle lumen,protein binding,Pf00887,1622,ENSG00000155368.16,DBI,2,PPAR signaling pathway,Sterol Regulatory Element-Binding Proteins (SREBP) signalling; PPAR Alpha Pathway; PPAR signaling pathway,Mitochondrial Fatty Acid Beta-Oxidation,8,High,1
Q14914,Prostaglandin reductase 1 OS=Homo sapiens OX=9606 GN=PTGR1 PE=1 SV=2,0,149.403,37,13,315,13,329,35.8,8.29,155577,,13,,metabolic process;response to stimulus,cytoplasm,catalytic activity,Pf00107,22949,ENSG00000106853.18,PTGR1,9,,NRF2 pathway,Synthesis of Leukotrienes (LT) and Eoxins (EX); Synthesis of Lipoxins (LX),7,High,1
P53041,Serine/threonine-protein phosphatase 5 OS=Homo sapiens OX=9606 GN=PPP5C PE=1 SV=1,0,149.284,40,17,157,17,499,56.8,6.28,69421,8.79,15,2,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding;signal transducer activity,"Pf00149, Pf00515, Pf07719, Pf08321, Pf12895, Pf13371, Pf13414, Pf13424, Pf13432, Pf14559",5536,ENSG00000011485.14,PPP5C,19,MAPK signaling pathway,MAPK Signaling Pathway; ATM Signaling Network in Development and Disease,Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Negative regulation of MAPK pathway; Interleukin-20 family signaling,16,High,1
Q5JPH6,"Probable glutamate--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=EARS2 PE=1 SV=2",0,149.06,39,17,175,17,523,58.7,8.76,82543,0,17,1,metabolic process,cytoplasm;mitochondrion;organelle lumen,catalytic activity;metal ion binding;nucleotide binding;RNA binding,Pf00749,124454,ENSG00000103356.15,EARS2,16,Aminoacyl-tRNA biosynthesis; Metabolic pathways; Porphyrin and chlorophyll metabolism,,Mitochondrial tRNA aminoacylation,7,High,1
Q96MM6,Heat shock 70 kDa protein 12B OS=Homo sapiens OX=9606 GN=HSPA12B PE=1 SV=2,0,149.017,34,24,290,21,686,75.6,8.53,140396,2.06,24,1,,,nucleotide binding;protein binding,,116835,ENSG00000132622.10,HSPA12B,20,,,Regulation of HSF1-mediated heat shock response,4,High,1
P16435,NADPH--cytochrome P450 reductase OS=Homo sapiens OX=9606 GN=POR PE=1 SV=2,0,148.919,34,19,205,19,677,76.6,5.58,93892,0,19,1,metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding,"Pf00175, Pf00258, Pf00667",5447,,POR,7,,,Cytochrome P450 - arranged by substrate type,4,High,1
P13796,Plastin-2 OS=Homo sapiens OX=9606 GN=LCP1 PE=1 SV=6,0,148.9,49,23,180,20,627,70.2,5.43,85353,0,23,1,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane,metal ion binding;protein binding,"Pf00036, Pf00307, Pf13405, Pf13499",3936,ENSG00000136167.13,LCP1,13,,,Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Interleukin-12 family signaling,5,High,1
P17612,cAMP-dependent protein kinase catalytic subunit alpha OS=Homo sapiens OX=9606 GN=PRKACA PE=1 SV=2,0,148.764,30,13,686,4,351,40.6,8.79,321770,0,13,1,cell communication;cell organization and biogenesis;cellular homeostasis;coagulation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;mitochondrion;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf07714, Pf14531",5566,ENSG00000072062.13,PRKACA,19,Thyroid hormone signaling pathway; Parkinson's disease; Inflammatory mediator regulation of TRP channels; Calcium signaling pathway; Serotonergic synapse; Renin secretion; Morphine addiction; Thyroid hormone synthesis; Gastric acid secretion; Estrogen signaling pathway; Dilated cardiomyopathy; Taste transduction; Cocaine addiction; GnRH signaling pathway; Glutamatergic synapse; Olfactory transduction; Insulin secretion; Aldosterone synthesis and secretion; Alcoholism; Longevity regulating pathway; Amoebiasis; Progesterone-mediated oocyte maturation; Pathways in cancer; Wnt signaling pathway; Salivary secretion; Regulation of lipolysis in adipocytes; Dopaminergic synapse; Amphetamine addiction; Circadian entrainment; HTLV-I infection; Hedgehog signaling pathway; Chemokine signaling pathway; Ovarian steroidogenesis; Adrenergic signaling in cardiomyocytes; Oocyte meiosis; Ras signaling pathway; Vascular smooth muscle contraction; MAPK signaling pathway; Proteoglycans in cancer; Longevity regulating pathway - multiple species; Melanogenesis; Viral carcinogenesis; Glucagon signaling pathway; Gap junction; Platelet activation; Long-term potentiation; Cholinergic synapse; Endocrine and other factor-regulated calcium reabsorption; cAMP signaling pathway; Endocrine resistance; Oxytocin signaling pathway; Vibrio cholerae infection; Epstein-Barr virus infection; GABAergic synapse; Bile secretion; Vasopressin-regulated water reabsorption; Insulin signaling pathway; Retrograde endocannabinoid signaling; Prion diseases,Nicotine Activity on Dopaminergic Neurons; Sterol Regulatory Element-Binding Proteins (SREBP) signalling; miRs in Muscle Cell Differentiation; Follicle Stimulating Hormone (FSH) signaling pathway; Regulation of Microtubule Cytoskeleton; Dopamine metabolism; Common Pathways Underlying Drug Addiction; Mesodermal Commitment Pathway; IL-3 Signaling Pathway; Myometrial Relaxation and Contraction Pathways; G Protein Signaling Pathways; MAPK Signaling Pathway; Endochondral Ossification; Calcium Regulation in the Cardiac Cell; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways; Estrogen signaling pathway,"Triglyceride catabolism; Glycolysis; ROBO receptors bind AKAP5; Regulation of PLK1 Activity at G2/M Transition; HDL assembly; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; GLI3 is processed to GLI3R by the proteasome; Vasopressin regulates renal water homeostasis via Aquaporins; Factors involved in megakaryocyte development and platelet production; Signaling by GPCR; Rap1 signalling; Degradation of GLI1 by the proteasome; PKA activation in glucagon signalling; Degradation of GLI2 by the proteasome; CREB phosphorylation through the activation of Adenylate Cyclase; Ion homeostasis; DARPP-32 events; Interleukin-3, 5 and GM-CSF signaling; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; VEGFA-VEGFR2 Pathway; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Recruitment of mitotic centrosome proteins and complexes; CD209 (DC-SIGN) signaling; PKA-mediated phosphorylation of key metabolic factors; PKA activation; RET signaling; MAPK6/MAPK4 signaling",158,High,1
Q9UQ80,Proliferation-associated protein 2G4 OS=Homo sapiens OX=9606 GN=PA2G4 PE=1 SV=3,0,148.662,43,15,255,15,394,43.8,6.55,130646,,15,,cell proliferation;metabolic process;regulation of biological process;transport,cytoplasm;extracellular;membrane;nucleus;organelle lumen,DNA binding;protein binding;RNA binding,Pf00557,5036,ENSG00000170515.13,PA2G4,12,,,Neutrophil degranulation,3,High,1
Q9UJ70,N-acetyl-D-glucosamine kinase OS=Homo sapiens OX=9606 GN=NAGK PE=1 SV=4,0,148.562,54,15,242,15,344,37.4,6.24,111622,1.63,15,1,metabolic process,cytosol,catalytic activity;nucleotide binding;protein binding,Pf01869,55577,ENSG00000124357.12,NAGK,2,Amino sugar and nucleotide sugar metabolism; Metabolic pathways,,Synthesis of UDP-N-acetyl-glucosamine,8,High,1
Q15942,Zyxin OS=Homo sapiens OX=9606 GN=ZYX PE=1 SV=1,0,148.524,43,17,351,16,572,61.2,6.67,166032,0,17,1,cell communication;cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,metal ion binding;protein binding;RNA binding,Pf00412,7791,ENSG00000159840.15,ZYX,7,Focal adhesion,Integrin-mediated Cell Adhesion; Focal Adhesion,,3,High,1
P41091,Eukaryotic translation initiation factor 2 subunit 3 OS=Homo sapiens OX=9606 GN=EIF2S3 PE=1 SV=3,0,148.431,39,18,277,18,472,51.1,8.4,124271,9.04,16,2,metabolic process;transport,cytoplasm;cytosol;nucleus,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00009, Pf03144, Pf09173",1968,ENSG00000130741.10,EIF2S3,X,RNA transport,Translation Factors,"Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; ABC-family proteins mediated transport; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Recycling of eIF2:GDP; Ribosomal scanning and start codon recognition",15,High,1
O75380,"NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS6 PE=1 SV=1",0,148.415,52,11,675,11,124,13.7,8.28,332658,114.21,10,2,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion,catalytic activity,Pf10276,4726,ENSG00000145494.11,NDUFS6,5,Parkinson's disease; Oxidative phosphorylation; Huntington's disease; Metabolic pathways; Alzheimer's disease; Non-alcoholic fatty liver disease (NAFLD),Electron Transport Chain; Oxidative phosphorylation,Complex I biogenesis,13,High,1
O43488,Aflatoxin B1 aldehyde reductase member 2 OS=Homo sapiens OX=9606 GN=AKR7A2 PE=1 SV=3,0,148.409,33,10,318,10,359,39.6,7.17,156040,0,10,1,metabolic process,cytoplasm;cytosol;Golgi,catalytic activity;protein binding,Pf00248,8574,ENSG00000053371.12,AKR7A2,1,Metabolism of xenobiotics by cytochrome P450,Aflatoxin B1 metabolism; Metapathway biotransformation,Aflatoxin activation and detoxification,6,High,1
O00560,Syntenin-1 OS=Homo sapiens OX=9606 GN=SDCBP PE=1 SV=1,0,148.31,47,10,193,9,298,32.4,7.53,98967,,10,,cell communication;cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;extracellular;membrane;nucleus;organelle lumen,protein binding,"Pf00595, Pf13180",6386,ENSG00000137575.11,SDCBP,8,,Ectoderm Differentiation,Ephrin signaling; Neutrophil degranulation; Neurofascin interactions,10,High,1
P0DJI9,Serum amyloid A-2 protein OS=Homo sapiens OX=9606 GN=SAA2 PE=1 SV=1,0,148.23,39,13,646,4,122,13.5,9.14,321275,62.87,12,2,cellular component movement;defense response;response to stimulus,extracellular,,Pf00277,6289,ENSG00000134339.8,SAA2,11,,Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism,,3,High,1
O95168,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 OS=Homo sapiens OX=9606 GN=NDUFB4 PE=1 SV=3,0,147.999,48,15,683,15,129,15.2,9.85,344121,13.24,15,2,cell organization and biogenesis;metabolic process;response to stimulus;transport,membrane;mitochondrion,catalytic activity,Pf07225,4710,ENSG00000065518.7,NDUFB4,3,Oxidative phosphorylation; Metabolic pathways; Parkinson's disease; Non-alcoholic fatty liver disease (NAFLD); Alzheimer's disease; Huntington's disease,Electron Transport Chain; Oxidative phosphorylation,Complex I biogenesis,13,High,1
P05198,Eukaryotic translation initiation factor 2 subunit 1 OS=Homo sapiens OX=9606 GN=EIF2S1 PE=1 SV=3,0,147.975,59,20,243,20,315,36.1,5.08,111650,0,20,1,cell communication;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus;ribosome,protein binding;RNA binding,"Pf00575, Pf07541",1965,ENSG00000134001.12,EIF2S1,14,RNA transport; Protein processing in endoplasmic reticulum; Herpes simplex infection; Non-alcoholic fatty liver disease (NAFLD); Hepatitis C; Influenza A; Measles; Apoptosis,Translation Factors; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway,"Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; ABC-family proteins mediated transport; Translation initiation complex formation; PERK regulates gene expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Recycling of eIF2:GDP; Ribosomal scanning and start codon recognition",25,High,1
P23526,Adenosylhomocysteinase OS=Homo sapiens OX=9606 GN=AHCY PE=1 SV=4,0,147.626,41,20,439,20,432,47.7,6.34,197286,3.66,20,4,defense response;metabolic process;response to stimulus;transport,cytoplasm;cytosol;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00670, Pf02254, Pf02826, Pf05221",191,ENSG00000101444.12,AHCY,20,Metabolic pathways; Cysteine and methionine metabolism,Folate Metabolism; Trans-sulfuration pathway; One Carbon Metabolism; Trans-sulfuration and one carbon metabolism,"Metabolism of ingested SeMet, Sec, MeSec into H2Se; Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD); Sulfur amino acid metabolism; Methylation",18,High,1
Q92945,Far upstream element-binding protein 2 OS=Homo sapiens OX=9606 GN=KHSRP PE=1 SV=4,0,147.526,42,19,185,18,711,73.1,7.3,88092,0,19,1,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus,DNA binding;protein binding;RNA binding,"Pf00013, Pf07650, Pf09005, Pf13014",8570,ENSG00000088247.17,KHSRP,19,,Preimplantation Embryo,ATF4 activates genes; KSRP (KHSRP) binds and destabilizes mRNA,8,High,1
P02774,Vitamin D-binding protein OS=Homo sapiens OX=9606 GN=GC PE=1 SV=2,0,147.519,25,13,604,13,474,52.9,5.45,299477,24.96,12,4,,,,,,,,,,,,0,High,1
O75116,Rho-associated protein kinase 2 OS=Homo sapiens OX=9606 GN=ROCK2 PE=1 SV=4,0,147.496,24,28,126,25,1388,160.8,6.02,51711,,28,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,catalytic activity;metal ion binding;motor activity;nucleotide binding;protein binding;RNA binding;structural molecule activity,"Pf00069, Pf00130, Pf01576, Pf01636, Pf02185, Pf02463, Pf04111, Pf04156, Pf05557, Pf05622, Pf05667, Pf06160, Pf07714, Pf07888, Pf08912, Pf09726, Pf09731, Pf11559, Pf12128, Pf12718, Pf12795, Pf13166, Pf14531, Pf14915",9475,ENSG00000134318.13,ROCK2,2,Proteoglycans in cancer; cGMP-PKG signaling pathway; cAMP signaling pathway; Regulation of actin cytoskeleton; Wnt signaling pathway; Vascular smooth muscle contraction; Shigellosis; Chemokine signaling pathway; Oxytocin signaling pathway; Leukocyte transendothelial migration; Pathogenic Escherichia coli infection; Salmonella infection; Platelet activation; Focal adhesion; Axon guidance; Pathways in cancer; Sphingolipid signaling pathway,Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated Cell Adhesion; Leptin signaling pathway; Pathogenic Escherichia coli infection; Spinal Cord Injury; Focal Adhesion; Association Between Physico-Chemical Features and Toxicity Associated Pathways; VEGFA-VEGFR2 Signaling Pathway; Chemokine signaling pathway; Regulation of Actin Cytoskeleton; G13 Signaling Pathway,EPHA-mediated growth cone collapse; G alpha (12/13) signalling events; EPHB-mediated forward signaling; RHO GTPases Activate ROCKs; Sema4D induced cell migration and growth-cone collapse; VEGFA-VEGFR2 Pathway,47,High,1
Q13564,NEDD8-activating enzyme E1 regulatory subunit OS=Homo sapiens OX=9606 GN=NAE1 PE=1 SV=1,0,147.464,44,18,119,18,534,60.2,5.4,52692,7.1,17,2,cell death;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;protein binding,Pf00899,8883,ENSG00000159593.14,NAE1,16,Alzheimer's disease,Alzheimers Disease,Neddylation,5,High,1
Q6PKG0,La-related protein 1 OS=Homo sapiens OX=9606 GN=LARP1 PE=1 SV=2,0,147.335,27,23,159,19,1096,123.4,8.82,74408,,23,,cell proliferation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;membrane,protein binding;RNA binding;translation regulator activity,Pf05383,23367,,LARP1,5,,,,0,High,1
P61106,Ras-related protein Rab-14 OS=Homo sapiens OX=9606 GN=RAB14 PE=1 SV=4,0,147.199,79,15,223,15,215,23.9,6.21,123525,3.15,13,3,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;endoplasmic reticulum;endosome;Golgi;membrane;vacuole,catalytic activity;nucleotide binding;protein binding,"Pf00009, Pf00025, Pf00071, Pf04670, Pf08477",51552,ENSG00000119396.10,RAB14,9,AMPK signaling pathway,Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,Translocation of GLUT4 to the plasma membrane; Neutrophil degranulation; Synthesis of PIPs at the plasma membrane; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation,18,High,1
Q5VWP3-2,Isoform 2 of Muscular LMNA-interacting protein OS=Homo sapiens OX=9606 GN=MLIP,0,146.949,63,14,223,2,234,25.7,5.35,83834,128.28,8,8,regulation of biological process,membrane;nucleus;organelle lumen,,Pf15274,90523,ENSG00000146147.14,MLIP,6,,,,0,High,1
P67809,Y-box-binding protein 1 OS=Homo sapiens OX=9606 GN=YBX1 PE=1 SV=3,0,146.689,60,17,159,14,324,35.9,9.88,72021,3.2,16,1,metabolic process;regulation of biological process,cytoplasm;cytosol;extracellular;membrane;nucleus;spliceosomal complex,DNA binding;protein binding;RNA binding,Pf00313,4904,ENSG00000065978.18,YBX1,1,,Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Mecp2 and Associated Rett Syndrome; mRNA Processing; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway,9,High,1
P60228,Eukaryotic translation initiation factor 3 subunit E OS=Homo sapiens OX=9606 GN=EIF3E PE=1 SV=1,0,146.664,45,19,258,19,445,52.2,6.04,122548,,19,,metabolic process;regulation of biological process,chromosome;cytoplasm;cytosol;membrane;nucleus,protein binding;RNA binding,"Pf01399, Pf09440",3646,ENSG00000104408.9,EIF3E,8,RNA transport; Hepatitis C,Translation Factors,"Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Ribosomal scanning and start codon recognition",14,High,1
Q63HR2,Tensin-2 OS=Homo sapiens OX=9606 GN=TNS2 PE=1 SV=2,0,146.657,26,25,145,23,1409,152.5,8.35,62876,0,25,1,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,membrane,catalytic activity;metal ion binding;protein binding;receptor activity;signal transducer activity,"Pf00017, Pf00130, Pf08416, Pf10409",23371,ENSG00000111077.17,TENC1; TNS2,12,,,,0,High,1
Q12802,A-kinase anchor protein 13 OS=Homo sapiens OX=9606 GN=AKAP13 PE=1 SV=2,0,146.281,14,26,399,26,2813,307.4,5.24,195184,3.61,25,3,cell differentiation;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,catalytic activity;metal ion binding;protein binding;signal transducer activity;structural molecule activity,"Pf00130, Pf00169, Pf00621",11214,ENSG00000170776.21,AKAP13,15,,G Protein Signaling Pathways,G alpha (12/13) signalling events; NRAGE signals death through JNK; Signalling by NGF; Rho GTPase cycle,12,High,1
Q13451,Peptidyl-prolyl cis-trans isomerase FKBP5 OS=Homo sapiens OX=9606 GN=FKBP5 PE=1 SV=2,0,146.244,46,18,161,18,457,51.2,5.9,69266,0,18,1,metabolic process,cytoplasm;cytosol;membrane;nucleus,catalytic activity;protein binding,"Pf00254, Pf00515, Pf07719, Pf13371, Pf13414, Pf13424, Pf13432",2289,ENSG00000096060.14,FKBP5,6,Estrogen signaling pathway,Farnesoid X Receptor  Pathway; Mecp2 and Associated Rett Syndrome,HSP90 chaperone cycle for steroid hormone receptors (SHR),6,High,1
P01019,Angiotensinogen OS=Homo sapiens OX=9606 GN=AGT PE=1 SV=1,0,146.171,35,17,347,17,485,53.1,6.32,166304,0,17,2,cell communication;cell growth;cell organization and biogenesis;cell proliferation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular,enzyme regulator activity;protein binding,Pf00079,183,ENSG00000135744.7,AGT,1,Renin secretion; Renin-angiotensin system,Physiological and Pathological Hypertrophy  of the Heart; MicroRNAs in cardiomyocyte hypertrophy; Adipogenesis; IL-6 signaling pathway; ACE Inhibitor Pathway; Monoamine Transport,Peptide ligand-binding receptors; Metabolism of Angiotensinogen to Angiotensins; Gastrin-CREB signalling pathway via PKC and MAPK; G alpha (i) signalling events; PPARA activates gene expression,24,High,1
Q9BY44,Eukaryotic translation initiation factor 2A OS=Homo sapiens OX=9606 GN=EIF2A PE=1 SV=3,0,146.094,49,20,160,20,585,64.9,8.87,64726,,20,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm,protein binding;RNA binding,Pf08662,83939,ENSG00000144895.11,EIF2A,3,,Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 Signaling Pathway,,2,High,1
Q5JRA6,Transport and Golgi organization protein 1 homolog OS=Homo sapiens OX=9606 GN=MIA3 PE=1 SV=1,0,146.067,19,27,94,27,1907,213.6,4.84,41794,1.71,27,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;membrane;organelle lumen,protein binding;transporter activity,"Pf02463, Pf04156, Pf06409, Pf07653, Pf09726, Pf13166",375056,ENSG00000154305.16,MIA3,1,,,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Cargo concentration in the ER,10,High,1
P01876,Immunoglobulin heavy constant alpha 1 OS=Homo sapiens OX=9606 GN=IGHA1 PE=1 SV=2,0,145.913,58,20,915,13,353,37.6,6.51,419263,112.2,17,5,cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,protein binding,"Pf07654, Pf08205",3493,ENSG00000211895.4; ENSG00000282633.1,IGHA1,14; CHR_HSCHR14_3_CTG1,,Inflammatory Response Pathway,Scavenging of heme from plasma; Cell surface interactions at the vascular wall,6,High,1
Q9NYL2-2,Isoform 2 of Mitogen-activated protein kinase kinase kinase 20 OS=Homo sapiens OX=9606 GN=MAP3K20,0,145.827,35,12,224,12,455,51.5,5.21,78382,126.99,9,3,cell death;cell differentiation;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding;signal transducer activity,"Pf00069, Pf07714",51776,ENSG00000091436.16,ZAK; MAP3K20,2,,MAPK Signaling Pathway,,1,High,1
P06858,Lipoprotein lipase OS=Homo sapiens OX=9606 GN=LPL PE=1 SV=1,0,145.505,38,14,274,14,475,53.1,8.15,121029,60.36,12,6,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cell surface;extracellular;membrane,catalytic activity;protein binding,"Pf00151, Pf01477, Pf12695, Pf12697",4023,ENSG00000175445.14,LPL,8,Glycerolipid metabolism; Alzheimer's disease; PPAR signaling pathway,Fatty Acid Beta Oxidation; Sterol Regulatory Element-Binding Proteins (SREBP) signalling; Alzheimers Disease; Adipogenesis; Aryl Hydrocarbon Receptor; Triacylglyceride Synthesis; Composition of Lipid Particles; Angiopoietin Like Protein 8 Regulatory Pathway; PPAR signaling pathway; Statin Pathway; Vitamin A and Carotenoid Metabolism,Signaling by GPCR; Assembly of active LPL and LIPC lipase complexes; Transcriptional regulation of white adipocyte differentiation; Retinoid metabolism and transport; Chylomicron remodeling,28,High,1
P15531,Nucleoside diphosphate kinase A OS=Homo sapiens OX=9606 GN=NME1 PE=1 SV=1,0,145.459,59,10,669,1,152,17.1,6.19,345669,0,10,2,cell differentiation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;mitochondrion;nucleus,catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding,Pf00334,4830,ENSG00000239672.7,NME1,17,Purine metabolism; Metabolic pathways; Pyrimidine metabolism,,Interconversion of nucleotide di- and triphosphates,6,High,1
P51991-2,Isoform 2 of Heterogeneous nuclear ribonucleoprotein A3 OS=Homo sapiens OX=9606 GN=HNRNPA3,0,145.371,31,13,273,1,356,37,8.31,136376,16.59,12,3,metabolic process;transport,cytoplasm;nucleus;spliceosomal complex,protein binding;RNA binding;transporter activity,"Pf00076, Pf13893, Pf14259",220988,ENSG00000170144.20,HNRNPA3,2,,,,0,High,1
Q7L311,Armadillo repeat-containing X-linked protein 2 OS=Homo sapiens OX=9606 GN=ARMCX2 PE=2 SV=1,0,145.37,47,15,424,15,632,65.6,8.53,182305,15.73,14,4,,membrane;mitochondrion,protein binding,"Pf00514, Pf04826, Pf09759",9823,ENSG00000184867.13,ARMCX2,X,,,,0,High,1
P68036,Ubiquitin-conjugating enzyme E2 L3 OS=Homo sapiens OX=9606 GN=UBE2L3 PE=1 SV=1,0,145.333,62,13,435,13,154,17.9,8.51,210102,1.94,13,1,cell proliferation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding;RNA binding,Pf00179,7332,ENSG00000185651.14,UBE2L3,22,Ubiquitin mediated proteolysis; Parkinson's disease,Parkin-Ubiquitin Proteasomal System pathway; Parkinsons Disease Pathway,Synthesis of active ubiquitin: roles of E1 and E2 enzymes; E3 ubiquitin ligases ubiquitinate target proteins; Antigen processing: Ubiquitination & Proteasome degradation,13,High,1
P22570,"NADPH:adrenodoxin oxidoreductase, mitochondrial OS=Homo sapiens OX=9606 GN=FDXR PE=1 SV=3",0,145.21,49,22,205,22,491,53.8,8.44,88137,1.92,22,2,metabolic process;transport,mitochondrion;organelle lumen,catalytic activity;protein binding,Pf13450,2232,,FDXR,17,,,"Endogenous sterols; Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR); Electron transport from NADPH to Ferredoxin; Pregnenolone biosynthesis",15,High,1
P51911,Calponin-1 OS=Homo sapiens OX=9606 GN=CNN1 PE=1 SV=2,0,145.047,51,11,270,10,297,33.2,9.07,132506,0,11,1,cell organization and biogenesis;regulation of biological process,cytoskeleton,protein binding,"Pf00307, Pf00402",1264,ENSG00000130176.7,CNN1,19,,Endothelin Pathways; Myometrial Relaxation and Contraction Pathways,,2,High,1
P49591,"Serine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=SARS PE=1 SV=3",0,144.864,39,18,188,18,514,58.7,6.43,89556,,18,,metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding,"Pf00587, Pf02403",6301,ENSG00000031698.12,SARS,1,Aminoacyl-tRNA biosynthesis,,Selenocysteine synthesis; Cytosolic tRNA aminoacylation,9,High,1
O94925,"Glutaminase kidney isoform, mitochondrial OS=Homo sapiens OX=9606 GN=GLS PE=1 SV=1",0,144.113,36,17,192,4,669,73.4,7.77,83272,,17,,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;mitochondrion;organelle lumen,catalytic activity;protein binding,"Pf04960, Pf12796",2744,ENSG00000115419.12,GLS,2,"Proximal tubule bicarbonate reclamation; Arginine biosynthesis; Metabolic pathways; Central carbon metabolism in cancer; Alanine, aspartate and glutamate metabolism; MicroRNAs in cancer; Glutamatergic synapse; D-Glutamine and D-glutamate metabolism; GABAergic synapse",Amino Acid metabolism,Amino acid synthesis and interconversion (transamination); TP53 Regulates Metabolic Genes; Glutamate Neurotransmitter Release Cycle,22,High,1
Q9Y224,"RNA transcription, translation and transport factor protein OS=Homo sapiens OX=9606 GN=RTRAF PE=1 SV=1",0,144.084,59,13,264,13,244,28.1,6.65,134178,0,12,1,metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;nucleus,protein binding;RNA binding,Pf10036,51637,ENSG00000087302.8,C14orf166; RTRAF,14,,,tRNA processing in the nucleus,3,High,1
P25787,Proteasome subunit alpha type-2 OS=Homo sapiens OX=9606 GN=PSMA2 PE=1 SV=2,0,144.057,46,8,436,8,234,25.9,7.43,211814,5.48,8,2,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;nucleus;organelle lumen;proteasome,catalytic activity;protein binding,"Pf00227, Pf10584",5683,ENSG00000256646.7; ENSG00000106588.10,PSMA2,7,Proteasome,Proteasome Degradation,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Neutrophil degranulation; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,151,High,1
Q9Y2Z4,"Tyrosine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=YARS2 PE=1 SV=2",0,144.036,45,14,183,14,477,53.2,8.98,87230,,14,,metabolic process,cytoplasm;cytosol;mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding;RNA binding,Pf00579,51067,ENSG00000139131.12,YARS2,12,Aminoacyl-tRNA biosynthesis,,Mitochondrial tRNA aminoacylation,5,High,1
Q9Y235,C->U-editing enzyme APOBEC-2 OS=Homo sapiens OX=9606 GN=APOBEC2 PE=1 SV=1,0,143.806,65,12,355,12,224,25.7,4.84,168889,42.86,9,7,metabolic process;regulation of biological process,,catalytic activity;metal ion binding;protein binding;RNA binding,"Pf05240, Pf08210",10930,ENSG00000124701.5,APOBEC2,6,,,Formation of the Editosome,4,High,1
Q96DC8,"Enoyl-CoA hydratase domain-containing protein 3, mitochondrial OS=Homo sapiens OX=9606 GN=ECHDC3 PE=1 SV=2",0,143.548,55,13,321,13,303,32.6,8.65,145685,27.99,11,3,metabolic process,mitochondrion,catalytic activity,Pf00378,79746,ENSG00000134463.14,ECHDC3,10,,Fatty Acid Biosynthesis,,1,High,1
O75964,"ATP synthase subunit g, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5MG PE=1 SV=3",0,143.464,83,17,1401,17,103,11.4,9.64,781592,7.63,17,3,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion,catalytic activity;transporter activity,Pf04718,10632,ENSG00000167283.7,ATP5L,11,Oxidative phosphorylation; Metabolic pathways,Electron Transport Chain; Oxidative phosphorylation,Cristae formation; Formation of ATP by chemiosmotic coupling,11,High,1
Q9NVJ2,ADP-ribosylation factor-like protein 8B OS=Homo sapiens OX=9606 GN=ARL8B PE=1 SV=1,0,143.225,61,12,287,7,186,21.5,8.43,141499,9.72,11,1,cell division;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;endosome;membrane;vacuole,catalytic activity;nucleotide binding;protein binding;signal transducer activity,"Pf00025, Pf00071, Pf00503, Pf04670, Pf08477, Pf09439",55207,ENSG00000134108.12,ARL8B,3,,,,0,High,1
P07451,Carbonic anhydrase 3 OS=Homo sapiens OX=9606 GN=CA3 PE=1 SV=3,0,143.201,67,13,199,13,260,29.5,7.34,86554,,13,,metabolic process;response to stimulus;transport,cytoplasm;cytosol,catalytic activity;metal ion binding,Pf00194,761,ENSG00000164879.6,CA3,8,Nitrogen metabolism,,Reversible hydration of carbon dioxide,3,High,1
P08240,Signal recognition particle receptor subunit alpha OS=Homo sapiens OX=9606 GN=SRPRA PE=1 SV=2,0,143.184,35,18,205,18,638,69.8,8.95,92431,0,18,2,cell organization and biogenesis;transport,endoplasmic reticulum;membrane,catalytic activity;nucleotide binding;RNA binding,"Pf00448, Pf02881, Pf03308, Pf04086",6734,ENSG00000182934.11,SRPR; SRPRA,11,Protein export,,XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane,7,High,1
O60784,Target of Myb protein 1 OS=Homo sapiens OX=9606 GN=TOM1 PE=1 SV=2,0,143.126,43,14,123,13,492,53.8,4.7,59999,0,14,1,transport,cytoplasm;cytosol;endosome;membrane,protein binding,"Pf00790, Pf03127",10043,ENSG00000100284.20,TOM1,22,,,Neutrophil degranulation,3,High,1
Q99807,"5-demethoxyubiquinone hydroxylase, mitochondrial OS=Homo sapiens OX=9606 GN=COQ7 PE=1 SV=3",0,142.938,59,15,343,15,217,24.3,8.59,160196,16.6,14,3,metabolic process;regulation of biological process,membrane;mitochondrion;nucleus,catalytic activity;metal ion binding;protein binding,"Pf03232, Pf11867",10229,ENSG00000167186.10,COQ7,16,Metabolic pathways; Ubiquinone and other terpenoid-quinone biosynthesis,,Ubiquinol biosynthesis,6,High,1
Q9NZ45,CDGSH iron-sulfur domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CISD1 PE=1 SV=1,0,142.888,76,12,688,12,108,12.2,9.09,320057,50.74,10,5,regulation of biological process,membrane;mitochondrion,metal ion binding;protein binding,Pf09360,55847,ENSG00000122873.11,CISD1,10,,Adipogenesis,,1,High,1
P09669,Cytochrome c oxidase subunit 6C OS=Homo sapiens OX=9606 GN=COX6C PE=1 SV=2,0,142.647,79,15,1998,15,75,8.8,10.39,968861,155.23,14,3,metabolic process;transport,membrane;mitochondrion,catalytic activity;transporter activity,Pf02937,1345,ENSG00000164919.10,COX6C,8,Cardiac muscle contraction; Oxidative phosphorylation; Huntington's disease; Metabolic pathways; Alzheimer's disease; Non-alcoholic fatty liver disease (NAFLD); Parkinson's disease,Electron Transport Chain,TP53 Regulates Metabolic Genes; Respiratory electron transport,17,High,1
Q92598,Heat shock protein 105 kDa OS=Homo sapiens OX=9606 GN=HSPH1 PE=1 SV=1,0,142.601,33,20,200,19,858,96.8,5.39,89839,0,20,1,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;nucleus;organelle lumen,enzyme regulator activity;nucleotide binding;protein binding,Pf00012,10808,ENSG00000120694.19,HSPH1,13,Protein processing in endoplasmic reticulum,,Scavenging by Class F Receptors; Regulation of HSF1-mediated heat shock response,8,High,1
Q9NYY8,"FAST kinase domain-containing protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=FASTKD2 PE=1 SV=1",0,142.579,30,15,87,15,710,81.4,8.05,40382,,15,,cell organization and biogenesis;metabolic process,mitochondrion;nucleus,catalytic activity;RNA binding,"Pf06743, Pf08368, Pf08373",22868,ENSG00000118246.13,FASTKD2,2,,,,0,High,1
O14874,"[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial OS=Homo sapiens OX=9606 GN=BCKDK PE=1 SV=2",0,142.304,39,14,248,14,412,46.3,8.82,108328,10.31,14,3,metabolic process,mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding,"Pf02518, Pf10436",10295,ENSG00000103507.13,BCKDK,16,,,Branched-chain amino acid catabolism,3,High,1
Q9NQR4,Omega-amidase NIT2 OS=Homo sapiens OX=9606 GN=NIT2 PE=1 SV=1,0,142.066,44,14,243,14,276,30.6,7.21,125559,1.61,14,1,metabolic process;transport,cytoplasm;cytosol;extracellular;mitochondrion;organelle lumen,catalytic activity,Pf00795,56954,ENSG00000114021.11,NIT2,3,"Alanine, aspartate and glutamate metabolism",,Neutrophil degranulation,4,High,1
Q92665,"28S ribosomal protein S31, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS31 PE=1 SV=3",0,142.024,47,14,223,14,395,45.3,9.29,106956,8.4,14,1,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,protein binding;RNA binding;structural molecule activity,Pf15433,10240,ENSG00000102738.7,MRPS31,13,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
P82933,"28S ribosomal protein S9, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS9 PE=1 SV=2",0,141.971,42,17,206,17,396,45.8,9.51,96164,4.59,16,1,cell organization and biogenesis;metabolic process;response to stimulus,membrane;mitochondrion;ribosome,protein binding;RNA binding;structural molecule activity,Pf00380,64965,ENSG00000135972.8,MRPS9,2,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
O60749,Sorting nexin-2 OS=Homo sapiens OX=9606 GN=SNX2 PE=1 SV=2,0,141.969,38,18,186,16,519,58.4,5.12,83954,,18,,cell organization and biogenesis;transport,cytoplasm;cytosol;endosome;membrane;vacuole,protein binding,"Pf00787, Pf03700, Pf05667, Pf09325, Pf10456",6643,ENSG00000205302.6,SNX2,5,Endocytosis,,Golgi Associated Vesicle Biogenesis,6,High,1
Q5TBA9,Protein furry homolog OS=Homo sapiens OX=9606 GN=FRY PE=1 SV=1,0,141.604,11,27,143,25,3013,338.7,5.99,39085,113.7,18,12,cell organization and biogenesis;regulation of biological process,cytoplasm;cytoskeleton,enzyme regulator activity,"Pf14222, Pf14225, Pf14228",10129,ENSG00000073910.19,FRY,13,,,,0,High,1
P35613,Basigin OS=Homo sapiens OX=9606 GN=BSG PE=1 SV=2,0,141.48,30,12,342,12,385,42.2,5.66,175097,4.22,11,2,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,membrane;mitochondrion,protein binding;transporter activity,"Pf00047, Pf07679, Pf13895, Pf13927",682,ENSG00000172270.18,BSG,19,,Matrix Metalloproteinases,Integrin cell surface interactions; Proton-coupled monocarboxylate transport; Basigin interactions; Degradation of the extracellular matrix; Pyruvate metabolism,15,High,1
P46199,"Translation initiation factor IF-2, mitochondrial OS=Homo sapiens OX=9606 GN=MTIF2 PE=1 SV=2",0,141.314,27,16,256,15,727,81.3,7.15,108999,8.48,16,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,mitochondrion,catalytic activity;nucleotide binding;RNA binding,"Pf00009, Pf00071, Pf01926, Pf03144, Pf08477, Pf09439, Pf11987",4528,ENSG00000085760.14,MTIF2,2,,,Mitochondrial translation initiation,4,High,1
Q6PGP7,Tetratricopeptide repeat protein 37 OS=Homo sapiens OX=9606 GN=TTC37 PE=1 SV=1,0,141.214,18,21,137,21,1564,175.4,7.53,59412,,21,,metabolic process,cytoplasm;cytosol;nucleus,protein binding,"Pf00515, Pf13414, Pf13424, Pf13429, Pf13432, Pf14559",9652,ENSG00000198677.10,TTC37,5,RNA degradation,,mRNA decay by 3' to 5' exoribonuclease,4,High,1
P14314,Glucosidase 2 subunit beta OS=Homo sapiens OX=9606 GN=PRKCSH PE=1 SV=2,0,140.994,36,15,322,15,528,59.4,4.41,147655,2.42,15,2,metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;organelle lumen,metal ion binding;protein binding,"Pf07915, Pf12999, Pf13015",5589,ENSG00000130175.9,PRKCSH,19,Protein processing in endoplasmic reticulum,,Advanced glycosylation endproduct receptor signaling; Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Calnexin/calreticulin cycle,11,High,1
P25311,Zinc-alpha-2-glycoprotein OS=Homo sapiens OX=9606 GN=AZGP1 PE=1 SV=2,0,140.893,47,13,228,13,298,34.2,6.05,108591,0,13,1,metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane;nucleus,catalytic activity;protein binding;transporter activity,"Pf00129, Pf07654",563,ENSG00000160862.12,AZGP1,7,,,Miscellaneous transport and binding events,2,High,1
O75431,Metaxin-2 OS=Homo sapiens OX=9606 GN=MTX2 PE=1 SV=1,0,140.773,53,10,519,10,263,29.7,6.29,244244,,10,,transport,membrane;mitochondrion,protein binding,"Pf11801, Pf13410, Pf14497",10651,ENSG00000128654.13,MTX2,2,,,Cristae formation; Mitochondrial protein import; Metabolism of proteins,5,High,1
P52789,Hexokinase-2 OS=Homo sapiens OX=9606 GN=HK2 PE=1 SV=2,0,140.436,25,21,530,16,917,102.3,6.05,263779,0,21,1,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding,"Pf00349, Pf03727",3099,ENSG00000159399.9,HK2,2,"Insulin signaling pathway; Metabolic pathways; Starch and sucrose metabolism; Carbon metabolism; Carbohydrate digestion and absorption; Type II diabetes mellitus; HIF-1 signaling pathway; Fructose and mannose metabolism; Neomycin, kanamycin and gentamicin biosynthesis; Galactose metabolism; Amino sugar and nucleotide sugar metabolism; Central carbon metabolism in cancer; Glycolysis / Gluconeogenesis",Glycolysis and Gluconeogenesis,Glycolysis,18,High,1
P03915,NADH-ubiquinone oxidoreductase chain 5 OS=Homo sapiens OX=9606 GN=MT-ND5 PE=1 SV=2,0,140.389,25,9,459,9,603,67,9.03,233548,8.59,7,5,cell organization and biogenesis;metabolic process;response to stimulus;transport,membrane;mitochondrion,catalytic activity,"Pf00361, Pf00662, Pf06455",4540,ENSG00000198786.2,ND5,MT,Metabolic pathways; Oxidative phosphorylation; Parkinson's disease,Electron Transport Chain; Oxidative phosphorylation,Complex I biogenesis,10,High,1
Q14789,Golgin subfamily B member 1 OS=Homo sapiens OX=9606 GN=GOLGB1 PE=1 SV=2,0,140.354,14,34,92,33,3259,375.8,5,39687,0,33,1,cell organization and biogenesis;metabolic process;regulation of biological process;transport,Golgi;membrane,catalytic activity;DNA binding;motor activity;protein binding;RNA binding;transporter activity,"Pf01496, Pf01576, Pf04111, Pf07888, Pf09726",2804,ENSG00000173230.15,GOLGB1,3,,,COPI-mediated anterograde transport; Golgi Associated Vesicle Biogenesis,11,High,1
O75131,Copine-3 OS=Homo sapiens OX=9606 GN=CPNE3 PE=1 SV=1,0,140.285,22,16,545,15,537,60.1,5.85,255153,0,16,2,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;mitochondrion;nucleus,catalytic activity;protein binding;RNA binding;transporter activity,"Pf00168, Pf07002, Pf10138",8895,ENSG00000085719.12,CPNE3,8,,,Neutrophil degranulation; Glycerophospholipid biosynthesis,7,High,1
P84085,ADP-ribosylation factor 5 OS=Homo sapiens OX=9606 GN=ARF5 PE=1 SV=2,0,140.146,57,11,487,5,180,20.5,6.79,238828,1.65,11,2,regulation of biological process;response to stimulus;transport,cytoplasm;Golgi;membrane,catalytic activity;nucleotide binding;protein binding;signal transducer activity,"Pf00025, Pf00071, Pf00503, Pf01926, Pf04670, Pf08477, Pf09439",381,ENSG00000004059.10,ARF5,7,Endocytosis,,COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport,12,High,1
Q9HC38,Glyoxalase domain-containing protein 4 OS=Homo sapiens OX=9606 GN=GLOD4 PE=1 SV=1,0,140.137,48,15,236,15,313,34.8,5.6,109639,0,15,1,,mitochondrion,protein binding,"Pf00903, Pf12681",51031,ENSG00000167699.13,GLOD4,17,,,,0,High,1
Q96AN5,Transmembrane protein 143 OS=Homo sapiens OX=9606 GN=TMEM143 PE=2 SV=1,0,139.943,34,12,358,12,459,51.7,9.67,168380,45.48,11,6,,membrane;mitochondrion,,,55260,ENSG00000161558.10,TMEM143,19,,,,0,High,1
P61981,14-3-3 protein gamma OS=Homo sapiens OX=9606 GN=YWHAG PE=1 SV=2,0,139.738,47,11,1055,6,247,28.3,4.89,560841,0,11,2,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;mitochondrion,enzyme regulator activity;protein binding;RNA binding,Pf00244,7532,ENSG00000170027.6,YWHAG,7,PI3K-Akt signaling pathway; Epstein-Barr virus infection; Oocyte meiosis; Cell cycle; Hippo signaling pathway; Viral carcinogenesis,Cell Cycle; Prolactin Signaling Pathway; Myometrial Relaxation and Contraction Pathways; Calcium Regulation in the Cardiac Cell; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Activation of BAD and translocation to mitochondria ; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; Translocation of GLUT4 to the plasma membrane; TP53 Regulates Metabolic Genes; RHO GTPases activate PKNs,48,High,1
P54577,"Tyrosine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=YARS PE=1 SV=4",0,139.701,51,26,225,26,528,59.1,7.05,89799,0,26,1,cell death;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,catalytic activity;nucleotide binding;protein binding;RNA binding;signal transducer activity,"Pf00579, Pf01588",8565,ENSG00000134684.10,YARS,1,Aminoacyl-tRNA biosynthesis,,Cytosolic tRNA aminoacylation,5,High,1
Q9C0D5,Protein TANC1 OS=Homo sapiens OX=9606 GN=TANC1 PE=1 SV=3,0,139.382,23,30,89,30,1861,202.1,8.32,37478,2.06,29,1,cell organization and biogenesis;response to stimulus,membrane,protein binding,"Pf00023, Pf12796, Pf13414, Pf13606, Pf13637, Pf13857",85461,ENSG00000115183.14,TANC1,2,,,,0,High,1
P51149,Ras-related protein Rab-7a OS=Homo sapiens OX=9606 GN=RAB7A PE=1 SV=1,0,139.364,70,14,448,14,207,23.5,6.7,231987,0,14,1,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;Golgi;membrane;vacuole,catalytic activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf01926, Pf04670, Pf07728, Pf08477",7879,ENSG00000075785.12,RAB7A,3,Phagosome; Endocytosis; Tuberculosis; Salmonella infection; Amoebiasis,,TBC/RABGAPs; Neutrophil degranulation; MHC class II antigen presentation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation,18,High,1
Q9Y6N5,"Sulfide:quinone oxidoreductase, mitochondrial OS=Homo sapiens OX=9606 GN=SQOR PE=1 SV=1",0,139.341,58,23,232,23,450,49.9,9.11,99049,0,23,1,metabolic process,membrane;mitochondrion,catalytic activity,"Pf07992, Pf13738",58472,ENSG00000137767.13,SQRDL; SQOR,15,Sulfur metabolism,,Sulfide oxidation to sulfate,6,High,1
P00395,Cytochrome c oxidase subunit 1 OS=Homo sapiens OX=9606 GN=MT-CO1 PE=1 SV=1,0,139.331,28,9,380,9,513,57,6.7,149859,79.81,8,3,metabolic process;response to stimulus;transport,membrane;mitochondrion,catalytic activity;metal ion binding;protein binding;transporter activity,Pf00115,4512,ENSG00000198804.2,COX1,MT,Non-alcoholic fatty liver disease (NAFLD); Parkinson's disease; Metabolic pathways; Alzheimer's disease; Cardiac muscle contraction; Oxidative phosphorylation; Huntington's disease,Electron Transport Chain; Effects of Nitric Oxide; Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis,TP53 Regulates Metabolic Genes; Respiratory electron transport,19,High,1
P50461,Cysteine and glycine-rich protein 3 OS=Homo sapiens OX=9606 GN=CSRP3 PE=1 SV=1,0,139.327,68,12,344,11,194,21,8.54,141904,243.33,8,4,cell differentiation;cell organization and biogenesis;cellular homeostasis;development;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;nucleus,metal ion binding;protein binding;structural molecule activity,Pf00412,8048,ENSG00000129170.8,CSRP3,11,,,,0,High,1
Q12849,G-rich sequence factor 1 OS=Homo sapiens OX=9606 GN=GRSF1 PE=1 SV=3,0,139.2,50,20,156,20,480,53.1,6.19,66024,0,20,1,metabolic process,cytoplasm;mitochondrion,RNA binding,"Pf00076, Pf14259",2926,ENSG00000132463.13,GRSF1,4,,,Viral mRNA Translation,6,High,1
P06748,Nucleophosmin OS=Homo sapiens OX=9606 GN=NPM1 PE=1 SV=2,0,139.19,28,9,393,9,294,32.6,4.78,194568,7.56,9,3,cell growth;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,DNA binding;enzyme regulator activity;protein binding;RNA binding,Pf03066,4869,ENSG00000181163.13,NPM1,5,,,Nuclear import of Rev protein; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Deposition of new CENPA-containing nucleosomes at the centromere,18,High,1
Q8NI60-4,"Isoform 4 of Atypical kinase COQ8A, mitochondrial OS=Homo sapiens OX=9606 GN=COQ8A",0,139.182,37,15,565,1,368,42.5,5.95,264871,22.83,13,5,metabolic process,mitochondrion,catalytic activity;nucleotide binding;protein binding,Pf03109,56997,,ADCK3; COQ8A,1,,,,0,High,1
P28827,Receptor-type tyrosine-protein phosphatase mu OS=Homo sapiens OX=9606 GN=PTPRM PE=1 SV=2,0,139.044,22,22,132,21,1452,163.6,6.65,49043,25.92,18,7,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;membrane,catalytic activity;protein binding;receptor activity;signal transducer activity,"Pf00041, Pf00047, Pf00102, Pf00629, Pf00782, Pf07679, Pf14566",5797,ENSG00000173482.16,PTPRM,18,Adherens junction; Cell adhesion molecules (CAMs),,,2,High,1
O75436,Vacuolar protein sorting-associated protein 26A OS=Homo sapiens OX=9606 GN=VPS26A PE=1 SV=2,0,138.409,57,15,115,14,327,38.1,6.57,51128,,15,,regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane;vacuole,protein binding;transporter activity,Pf03643,9559,ENSG00000122958.14,VPS26A,10,Endocytosis,,WNT ligand biogenesis and trafficking,4,High,1
P51114,Fragile X mental retardation syndrome-related protein 1 OS=Homo sapiens OX=9606 GN=FXR1 PE=1 SV=3,0,138.392,37,18,172,15,621,69.7,6.15,78673,,18,,cell death;cell differentiation;development;regulation of biological process,cytoplasm;cytosol;membrane;nucleus,protein binding;RNA binding,"Pf00013, Pf05641, Pf12235, Pf13014",8087,ENSG00000114416.17,FXR1,3,RNA transport,,Signaling by BRAF and RAF fusions,5,High,1
P05387,60S acidic ribosomal protein P2 OS=Homo sapiens OX=9606 GN=RPLP2 PE=1 SV=1,0,138.247,92,12,305,11,115,11.7,4.54,160946,0,12,2,cell organization and biogenesis;metabolic process;transport,cytosol;membrane;ribosome,protein binding;structural molecule activity,Pf00428,6181,ENSG00000177600.8,RPLP2,11,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
P20774,Mimecan OS=Homo sapiens OX=9606 GN=OGN PE=1 SV=1,0,138.129,39,12,817,12,298,33.9,5.63,361736,10.24,11,3,cell organization and biogenesis;metabolic process;regulation of biological process,extracellular;organelle lumen,protein binding,"Pf12799, Pf13855",4969,ENSG00000106809.10,OGN,9,,,Keratan sulfate biosynthesis; Defective CHST6 causes MCDC1; Defective ST3GAL3 causes MCT12 and EIEE15; Defective B4GALT1 causes B4GALT1-CDG (CDG-2d); Keratan sulfate degradation,12,High,1
O95210,Starch-binding domain-containing protein 1 OS=Homo sapiens OX=9606 GN=STBD1 PE=1 SV=1,0,137.908,47,15,179,15,358,39,5.73,85135,5.45,14,3,metabolic process;transport,cytosol;endoplasmic reticulum;membrane,protein binding,Pf00686,8987,ENSG00000118804.8,STBD1,4,,Exercise-induced Circadian Regulation,Neutrophil degranulation,4,High,1
P52907,F-actin-capping protein subunit alpha-1 OS=Homo sapiens OX=9606 GN=CAPZA1 PE=1 SV=3,0,137.852,62,13,295,10,286,32.9,5.69,138185,2.3,13,1,cell organization and biogenesis;cellular component movement;coagulation;defense response;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;extracellular,protein binding,Pf01267,829,ENSG00000116489.12,CAPZA1,1,Endocytosis,,COPI-independent Golgi-to-ER retrograde traffic; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Advanced glycosylation endproduct receptor signaling; Factors involved in megakaryocyte development and platelet production; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR); Interleukin-12 family signaling,26,High,1
P18124,60S ribosomal protein L7 OS=Homo sapiens OX=9606 GN=RPL7 PE=1 SV=1,0,137.809,51,18,437,18,248,29.2,10.65,205740,18.05,17,2,cell organization and biogenesis;metabolic process;transport,cytoplasm;cytosol;membrane;nucleus;ribosome,DNA binding;protein binding;RNA binding;structural molecule activity,"Pf00327, Pf08079",6129,ENSG00000147604.13,RPL7,8,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
O14744,Protein arginine N-methyltransferase 5 OS=Homo sapiens OX=9606 GN=PRMT5 PE=1 SV=4,0,137.774,35,22,185,22,637,72.6,6.29,77266,6.89,21,2,cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process,cytoplasm;cytosol;Golgi;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding,"Pf02475, Pf05185",10419,ENSG00000100462.15,PRMT5,14,RNA transport,,snRNP Assembly; Regulation of TP53 Activity through Methylation; RMTs methylate histone arginines,13,High,1
P14672,"Solute carrier family 2, facilitated glucose transporter member 4 OS=Homo sapiens OX=9606 GN=SLC2A4 PE=1 SV=1",0,137.594,25,12,276,12,509,54.8,6.93,117015,131.74,7,8,cell differentiation;metabolic process;response to stimulus;transport,cell surface;cytoplasm;cytosol;endosome;membrane,protein binding;transporter activity,"Pf00083, Pf07690, Pf13347",6517,ENSG00000181856.14,SLC2A4,17,FoxO signaling pathway; Insulin resistance; Type II diabetes mellitus; Insulin signaling pathway; Adipocytokine signaling pathway; AMPK signaling pathway,AMP-activated Protein Kinase (AMPK) Signaling; Type II diabetes mellitus; Cori Cycle; Adipogenesis; NRF2 pathway; Transcription factor regulation in adipogenesis; Angiopoietin Like Protein 8 Regulatory Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Insulin Signaling; Glycolysis and Gluconeogenesis,Translocation of GLUT4 to the plasma membrane; Transcriptional regulation of white adipocyte differentiation; Cellular hexose transport,24,High,1
P68400,Casein kinase II subunit alpha OS=Homo sapiens OX=9606 GN=CSNK2A1 PE=1 SV=1,0,137.558,52,16,157,16,391,45.1,7.74,77704,0,16,1,cell communication;cell death;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;cytosol;membrane;nucleus,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding,"Pf00069, Pf01636, Pf07714",1457,ENSG00000101266.17,CSNK2A1,20,Herpes simplex infection; Ribosome biogenesis in eukaryotes; Adherens junction; Tight junction; NF-kappa B signaling pathway; Epstein-Barr virus infection; Measles; Wnt signaling pathway,TNF alpha Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway,WNT mediated activation of DVL; Condensation of Prometaphase Chromosomes; Regulation of PTEN stability and activity; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Signal transduction by L1; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Synthesis of PC; Receptor Mediated Mitophagy; Regulation of TP53 Activity through Phosphorylation,46,High,1
Q15691,Microtubule-associated protein RP/EB family member 1 OS=Homo sapiens OX=9606 GN=MAPRE1 PE=1 SV=3,0,137.513,58,16,443,13,268,30,5.14,201006,,16,,cell division;cell organization and biogenesis;cell proliferation;regulation of biological process,cytoplasm;cytoskeleton;cytosol;Golgi,protein binding;RNA binding,"Pf00307, Pf03271",22919,ENSG00000101367.8,MAPRE1,20,,Regulation of Microtubule Cytoskeleton,Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; The role of GTSE1 in G2/M progression after G2 checkpoint,30,High,1
O14880,Microsomal glutathione S-transferase 3 OS=Homo sapiens OX=9606 GN=MGST3 PE=1 SV=1,0,137.486,70,12,592,12,152,16.5,9.38,300815,56.64,10,3,metabolic process;response to stimulus,endoplasmic reticulum;membrane,antioxidant activity;catalytic activity;protein binding,Pf01124,4259,ENSG00000143198.12,MGST3,1,Glutathione metabolism; Drug metabolism - cytochrome P450; Chemical carcinogenesis; Platinum drug resistance; Metabolism of xenobiotics by cytochrome P450,NRF2 pathway; Metapathway biotransformation,Glutathione conjugation; Aflatoxin activation and detoxification,12,High,1
Q12904,Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 OS=Homo sapiens OX=9606 GN=AIMP1 PE=1 SV=2,0,137.426,53,12,119,12,312,34.3,8.43,59993,0,12,1,cell communication;cell death;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus,cell surface;cytoplasm;cytosol;endoplasmic reticulum;extracellular;Golgi;membrane;nucleus,protein binding;RNA binding,Pf01588,9255,ENSG00000164022.16,AIMP1,4,,,Cytosolic tRNA aminoacylation; SeMet incorporation into proteins,8,High,1
P61224,Ras-related protein Rap-1b OS=Homo sapiens OX=9606 GN=RAP1B PE=1 SV=1,0,137.416,48,12,348,2,184,20.8,5.78,177263,0,12,1,cell organization and biogenesis;cell proliferation;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00009, Pf00071, Pf08477",5908,ENSG00000127314.17,RAP1B,12,cAMP signaling pathway; Leukocyte transendothelial migration; Renal cell carcinoma; Rap1 signaling pathway; Platelet activation; Ras signaling pathway; Pancreatic secretion; MAPK signaling pathway; Chemokine signaling pathway; Focal adhesion; Long-term potentiation; Neurotrophin signaling pathway,Integrin-mediated Cell Adhesion; Human Thyroid Stimulating Hormone (TSH) signaling pathway; Corticotropin-releasing hormone signaling pathway; Common Pathways Underlying Drug Addiction; Focal Adhesion; Signaling of Hepatocyte Growth Factor Receptor; MAPK Signaling Pathway; VEGFA-VEGFR2 Signaling Pathway; Chemokine signaling pathway,Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Signaling by BRAF and RAF fusions; MAP2K and MAPK activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; MET activates RAP1 and RAC1; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; p130Cas linkage to MAPK signaling for integrins; Rap1 signalling; Paradoxical activation of RAF signaling by kinase inactive BRAF; Neutrophil degranulation; Interleukin-12 family signaling; Interleukin-20 family signaling,55,High,1
Q9Y3Z3,Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 OS=Homo sapiens OX=9606 GN=SAMHD1 PE=1 SV=2,0,137.349,37,20,248,20,626,72.2,7.14,99841,0,20,1,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,membrane;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding,"Pf00536, Pf01966, Pf07647",25939,ENSG00000101347.8,SAMHD1,20,,,Nucleobase catabolism; Interferon alpha/beta signaling,7,High,1
Q86VN1,Vacuolar protein-sorting-associated protein 36 OS=Homo sapiens OX=9606 GN=VPS36 PE=1 SV=1,0,137.142,56,20,162,20,386,43.8,7.2,68370,0,20,1,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane;nucleus;vacuole,protein binding,"Pf04157, Pf11605",51028,ENSG00000136100.12,VPS36,13,Endocytosis,,Endosomal Sorting Complex Required For Transport (ESCRT),4,High,1
P43121,Cell surface glycoprotein MUC18 OS=Homo sapiens OX=9606 GN=MCAM PE=1 SV=2,0,136.923,32,16,159,15,646,71.6,5.76,72962,1.74,16,1,regulation of biological process,extracellular;membrane;nucleus,protein binding,"Pf00047, Pf07679, Pf07686, Pf08205, Pf13895, Pf13927",4162,ENSG00000076706.16,MCAM,11,,,,0,High,1
Q16647,Prostacyclin synthase OS=Homo sapiens OX=9606 GN=PTGIS PE=1 SV=1,0,136.701,39,17,209,16,500,57.1,7.31,91812,0,17,3,metabolic process;regulation of biological process;response to stimulus,cytoplasm;endoplasmic reticulum;membrane;nucleus,catalytic activity;metal ion binding;protein binding,Pf00067,5740,ENSG00000124212.5,PTGIS,20,Metabolic pathways; Arachidonic acid metabolism,Eicosanoid Synthesis; Adipogenesis; Prostaglandin Synthesis and Regulation,Eicosanoids; Sterols are 12-hydroxylated by CYP8B1; Synthesis of bile acids and bile salts via 27-hydroxycholesterol; Synthesis of bile acids and bile salts via 24-hydroxycholesterol; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Synthesis of Prostaglandins (PG) and Thromboxanes (TX); Nicotinamide salvaging,26,High,1
Q96PE7,"Methylmalonyl-CoA epimerase, mitochondrial OS=Homo sapiens OX=9606 GN=MCEE PE=1 SV=1",0,136.512,53,10,362,10,176,18.7,9.09,159624,13.48,10,3,metabolic process,mitochondrion;organelle lumen,catalytic activity;metal ion binding;protein binding,"Pf00903, Pf12681, Pf13468, Pf13669",84693,ENSG00000124370.10,MCEE,2,"Valine, leucine and isoleucine degradation; Metabolic pathways; Propanoate metabolism; Glyoxylate and dicarboxylate metabolism; Carbon metabolism",Vitamin B12 Metabolism,Propionyl-CoA catabolism,11,High,1
Q16777,Histone H2A type 2-C OS=Homo sapiens OX=9606 GN=HIST2H2AC PE=1 SV=4,0,136.124,56,14,2113,1,129,14,10.9,1148461,0,14,1,regulation of biological process,chromosome;nucleus,DNA binding;protein binding,"Pf00125, Pf00808",8338,ENSG00000184260.5,HIST2H2AC,1,Systemic lupus erythematosus; Alcoholism,,SIRT1 negatively regulates rRNA expression; UCH proteinases; RMTs methylate histone arginines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; NoRC negatively regulates rRNA expression; Meiotic synapsis; Transcriptional regulation by small RNAs; Meiotic recombination; PRC2 methylates histones and DNA; HDACs deacetylate histones; Formation of the beta-catenin:TCF transactivating complex; Metalloprotease DUBs; DNA methylation; Packaging Of Telomere Ends; Ub-specific processing proteases; Amyloid fiber formation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RNA Polymerase I Chain Elongation; HATs acetylate histones; Deposition of new CENPA-containing nucleosomes at the centromere; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); B-WICH complex positively regulates rRNA expression; RNA Polymerase I Promoter Opening; Oxidative Stress Induced Senescence,66,High,1
P30566,Adenylosuccinate lyase OS=Homo sapiens OX=9606 GN=ADSL PE=1 SV=2,0,136.082,43,14,220,14,484,54.9,7.11,102700,,14,,cell organization and biogenesis;metabolic process;response to stimulus,cytosol;mitochondrion,catalytic activity,"Pf00206, Pf10397",158,ENSG00000239900.12,ADSL,22,"Purine metabolism; Alanine, aspartate and glutamate metabolism; Metabolic pathways",Nucleotide Metabolism,Purine ribonucleoside monophosphate biosynthesis,8,High,1
Q2M2I8,AP2-associated protein kinase 1 OS=Homo sapiens OX=9606 GN=AAK1 PE=1 SV=3,0,135.958,27,17,134,16,961,103.8,6.6,58288,4.92,17,1,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf07714",22848,ENSG00000115977.18,AAK1,2,,,Cargo recognition for clathrin-mediated endocytosis,4,High,1
Q9UKV8,Protein argonaute-2 OS=Homo sapiens OX=9606 GN=AGO2 PE=1 SV=3,0,135.888,35,21,120,17,859,97.1,9.19,52881,,21,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding,"Pf02170, Pf02171, Pf08699",27161,ENSG00000123908.11,AGO2; EIF2C2,8,,,Post-transcriptional silencing by small RNAs; Ca2+ pathway; MicroRNA (miRNA) biogenesis; Competing endogenous RNAs (ceRNAs) regulate PTEN translation; Small interfering RNA (siRNA) biogenesis; Transcriptional regulation by small RNAs; Regulation of RUNX1 Expression and Activity; MAPK6/MAPK4 signaling; TP53 Regulates Metabolic Genes; Pre-NOTCH Transcription and Translation,26,High,1
Q8IWA4,Mitofusin-1 OS=Homo sapiens OX=9606 GN=MFN1 PE=1 SV=3,0,135.861,32,25,233,23,741,84.1,6.33,101641,2.61,24,3,cell communication;cell organization and biogenesis;metabolic process;response to stimulus,membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding,"Pf00350, Pf01926, Pf04799",55669,ENSG00000171109.18,MFN1,3,NOD-like receptor signaling pathway,,,1,High,1
Q9Y375,"Complex I intermediate-associated protein 30, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFAF1 PE=1 SV=2",0,135.778,51,15,172,15,327,37.7,7.64,82773,0,15,1,cell organization and biogenesis;metabolic process,cytosol;membrane;mitochondrion,protein binding,Pf08547,51103,ENSG00000137806.8,NDUFAF1,15,,,Complex I biogenesis,5,High,1
Q13263,Transcription intermediary factor 1-beta OS=Homo sapiens OX=9606 GN=TRIM28 PE=1 SV=5,0,135.648,36,17,136,17,835,88.5,5.77,62045,0,17,1,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,chromosome;nucleus,catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding,"Pf00628, Pf00643",10155,ENSG00000130726.11,TRIM28,19,,Corticotropin-releasing hormone signaling pathway; Mesodermal Commitment Pathway; ATM Signaling Network in Development and Disease,Generic Transcription Pathway,6,High,1
Q9UN86,Ras GTPase-activating protein-binding protein 2 OS=Homo sapiens OX=9606 GN=G3BP2 PE=1 SV=2,0,135.447,46,15,203,14,482,54.1,5.55,86862,,15,,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol,protein binding;RNA binding;structural molecule activity,"Pf00076, Pf02136, Pf14259",9908,ENSG00000138757.14,G3BP2,4,,,,0,High,1
P10301,Ras-related protein R-Ras OS=Homo sapiens OX=9606 GN=RRAS PE=1 SV=1,0,135.354,58,12,310,9,218,23.5,6.93,158765,1.67,12,1,cell differentiation;regulation of biological process;response to stimulus,membrane,catalytic activity;nucleotide binding;protein binding,"Pf00071, Pf08477",6237,ENSG00000126458.3,RRAS,19,Ras signaling pathway; HTLV-I infection; Phospholipase D signaling pathway; Axon guidance; Proteoglycans in cancer; Rap1 signaling pathway; cAMP signaling pathway; Regulation of actin cytoskeleton; MAPK signaling pathway; Tight junction,G Protein Signaling Pathways; Canonical  and Non-canonical Notch signaling; MAPK  and NFkB Signalling Pathways Inhibited by Yersinia YopJ; T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection; MAPK Cascade; Regulation of Actin Cytoskeleton,Sema4D mediated inhibition of cell attachment and migration; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; CREB phosphorylation through the activation of Ras,28,High,1
O60884,DnaJ homolog subfamily A member 2 OS=Homo sapiens OX=9606 GN=DNAJA2 PE=1 SV=1,0,135.236,42,15,252,15,412,45.7,6.48,105748,0,15,1,metabolic process;regulation of biological process;response to stimulus,cytosol;membrane,enzyme regulator activity;metal ion binding;nucleotide binding;protein binding,"Pf00226, Pf00684, Pf01556",10294,ENSG00000069345.11,DNAJA2,16,Protein processing in endoplasmic reticulum,,HSP90 chaperone cycle for steroid hormone receptors (SHR),4,High,1
Q15327,Ankyrin repeat domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ANKRD1 PE=1 SV=2,0,135.157,48,14,191,14,319,36.2,7.5,71422,80.37,11,6,cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,DNA binding;protein binding,"Pf00023, Pf12796, Pf13606, Pf13637, Pf13857",27063,ENSG00000148677.6,ANKRD1,10,,Hypertrophy Model,PPARA activates gene expression,5,High,1
O60504,Vinexin OS=Homo sapiens OX=9606 GN=SORBS3 PE=1 SV=2,0,135.108,47,22,200,20,671,75.3,9.45,87526,0,22,1,cell organization and biogenesis;regulation of biological process,cytoplasm;cytoskeleton;cytosol;nucleus,protein binding;structural molecule activity,"Pf00018, Pf02208, Pf07653, Pf14604",10174,ENSG00000120896.13,SORBS3,8,,,Smooth Muscle Contraction,2,High,1
Q96TA1,Protein Niban 2 OS=Homo sapiens OX=9606 GN=NIBAN2 PE=1 SV=3,0,134.993,33,17,105,17,746,84.1,6.19,49189,0,17,1,cell differentiation;cellular component movement;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;membrane;nucleus,protein binding,,64855,ENSG00000136830.11,FAM129B,9,,,,0,High,1
P38919,Eukaryotic initiation factor 4A-III OS=Homo sapiens OX=9606 GN=EIF4A3 PE=1 SV=4,0,134.782,47,18,223,15,411,46.8,6.73,104731,,18,,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus;spliceosomal complex,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00270, Pf00271",9775,ENSG00000141543.9,EIF4A3,17,Spliceosome; RNA transport; mRNA surveillance pathway,,ISG15 antiviral mechanism; mRNA 3'-end processing; mRNA Splicing - Major Pathway; Cleavage of Growing Transcript in the Termination Region ; Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Deadenylation of mRNA,27,High,1
Q9P0M6,Core histone macro-H2A.2 OS=Homo sapiens OX=9606 GN=H2AFY2 PE=1 SV=3,0,134.593,49,16,263,13,372,40,9.69,106668,0,16,1,cell organization and biogenesis;regulation of biological process,chromosome;nucleus,DNA binding;protein binding,"Pf00125, Pf01661",55506,ENSG00000099284.13,H2AFY2,10,Alcoholism; Systemic lupus erythematosus,Preimplantation Embryo,,3,High,1
P52895,Aldo-keto reductase family 1 member C2 OS=Homo sapiens OX=9606 GN=AKR1C2 PE=1 SV=3,0,134.532,42,13,193,10,323,36.7,7.49,84226,0,13,2,cell differentiation;metabolic process;regulation of biological process;response to stimulus,cytoplasm,catalytic activity,Pf00248,1646,ENSG00000151632.17,AKR1C2,10,Steroid hormone biosynthesis; Chemical carcinogenesis,Benzo(a)pyrene metabolism; Metapathway biotransformation,Synthesis of bile acids and bile salts via 27-hydroxycholesterol; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Synthesis of bile acids and bile salts via 24-hydroxycholesterol,12,High,1
Q12797,Aspartyl/asparaginyl beta-hydroxylase OS=Homo sapiens OX=9606 GN=ASPH PE=1 SV=3,0,134.508,32,22,190,20,758,85.8,5.01,75654,,22,,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;membrane;organelle lumen,catalytic activity;metal ion binding;protein binding;structural molecule activity,"Pf05118, Pf05279, Pf13414, Pf13428, Pf13432, Pf14559",444,ENSG00000198363.17,ASPH,8,,,Ion homeostasis; Stimuli-sensing channels,6,High,1
Q99733,Nucleosome assembly protein 1-like 4 OS=Homo sapiens OX=9606 GN=NAP1L4 PE=1 SV=1,0,134.304,51,13,342,11,375,42.8,4.69,168181,4.54,13,2,cell organization and biogenesis,cytoplasm;nucleus,protein binding;RNA binding,Pf00956,4676,ENSG00000273562.4; ENSG00000205531.12,NAP1L4,11; CHR_HSCHR11_1_CTG7,,,,0,High,1
Q15067-2,Isoform 2 of Peroxisomal acyl-coenzyme A oxidase 1 OS=Homo sapiens OX=9606 GN=ACOX1,0,134.242,39,16,99,2,660,74.6,7.62,36939,41.74,14,4,metabolic process;regulation of biological process,membrane;mitochondrion;nucleus;organelle lumen,catalytic activity;nucleotide binding;protein binding,"Pf01756, Pf02770, Pf14749",51,ENSG00000161533.11,ACOX1,17,Fatty acid degradation; cAMP signaling pathway; PPAR signaling pathway; Fatty acid metabolism; Biosynthesis of unsaturated fatty acids; alpha-Linolenic acid metabolism; Peroxisome; Metabolic pathways,Estrogen Receptor Pathway; PPAR signaling pathway,alpha-linolenic acid (ALA) metabolism; Beta-oxidation of very long chain fatty acids,17,High,1
P24821,Tenascin OS=Homo sapiens OX=9606 GN=TNC PE=1 SV=3,0,134.098,21,28,87,28,2201,240.7,4.89,31125,,28,,cell communication;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane;organelle lumen,protein binding,"Pf00041, Pf00147, Pf07974",3371,ENSG00000041982.15,TNC,9,PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; MicroRNAs in cancer,Focal Adhesion; TGF-beta Signaling Pathway; Amplification and Expansion of Oncogenic Pathways as Metastatic Traits; TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,ECM proteoglycans; Post-translational protein phosphorylation; Integrin cell surface interactions; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Syndecan interactions,18,High,1
P26196,Probable ATP-dependent RNA helicase DDX6 OS=Homo sapiens OX=9606 GN=DDX6 PE=1 SV=2,0,134.047,49,18,166,18,483,54.4,8.66,76046,0,18,1,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;mitochondrion;nucleus,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00270, Pf00271, Pf14617",1656,ENSG00000110367.11,DDX6,11,RNA degradation,,mRNA decay by 5' to 3' exoribonuclease,4,High,1
Q9UIA9,Exportin-7 OS=Homo sapiens OX=9606 GN=XPO7 PE=1 SV=3,0,134.026,26,24,137,24,1087,123.8,6.32,61495,,24,,transport,cytoplasm;nucleus,protein binding;transporter activity,Pf03810,23039,ENSG00000130227.16,XPO7,8,,,,0,High,1
Q9HCP6,Protein-cysteine N-palmitoyltransferase HHAT-like protein OS=Homo sapiens OX=9606 GN=HHATL PE=2 SV=1,0,133.907,25,12,360,12,504,56.7,7.12,161891,67.19,11,4,regulation of biological process,endoplasmic reticulum;membrane,,Pf03062,57467,ENSG00000010282.14,HHATL,3,,,,0,High,1
Q8WUM0,Nuclear pore complex protein Nup133 OS=Homo sapiens OX=9606 GN=NUP133 PE=1 SV=2,0,133.812,26,21,86,21,1156,128.9,5.1,32608,,21,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;transport,chromosome;cytosol;membrane;nucleus,protein binding;structural molecule activity;transporter activity,"Pf03177, Pf08801",55746,ENSG00000069248.11,NUP133,1,RNA transport,,Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; Separation of Sister Chromatids; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Resolution of Sister Chromatid Cohesion; Transport of Ribonucleoproteins into the Host Nucleus; RHO GTPases Activate Formins; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins,77,High,1
P35813,Protein phosphatase 1A OS=Homo sapiens OX=9606 GN=PPM1A PE=1 SV=1,0,133.775,48,14,230,11,382,42.4,5.36,101552,0,14,1,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,catalytic activity;metal ion binding;protein binding;signal transducer activity,"Pf00481, Pf07830",5494,ENSG00000100614.17,PPM1A,14,MAPK signaling pathway,TGF-beta Signaling Pathway; MAPK Signaling Pathway,Energy dependent regulation of mTOR by LKB1-AMPK; Downregulation of SMAD2/3:SMAD4 transcriptional activity,13,High,1
Q96DG6,Carboxymethylenebutenolidase homolog OS=Homo sapiens OX=9606 GN=CMBL PE=1 SV=1,0,133.672,48,14,702,14,245,28,7.18,379280,10.32,13,4,metabolic process,cytoplasm;cytosol,catalytic activity,"Pf00326, Pf01738, Pf12695",134147,ENSG00000164237.8,CMBL,5,Metabolic pathways,,Phase I - Functionalization of compounds,4,High,1
Q9Y2S7,Polymerase delta-interacting protein 2 OS=Homo sapiens OX=9606 GN=POLDIP2 PE=1 SV=1,0,133.383,61,18,142,18,368,42,8.63,63483,0,18,1,cell organization and biogenesis;regulation of biological process,mitochondrion;nucleus,DNA binding;protein binding,"Pf04379, Pf08755",26073,ENSG00000004142.11,POLDIP2,17,,,,0,High,1
Q9NTX5,Ethylmalonyl-CoA decarboxylase OS=Homo sapiens OX=9606 GN=ECHDC1 PE=1 SV=2,0,133.366,59,13,166,13,307,33.7,8.21,85545,0,13,2,metabolic process,cytoplasm;cytosol;mitochondrion,catalytic activity,Pf00378,55862,ENSG00000093144.18,ECHDC1,6,Propanoate metabolism,Fatty Acid Biosynthesis,,2,High,1
Q13596,Sorting nexin-1 OS=Homo sapiens OX=9606 GN=SNX1 PE=1 SV=3,0,133.337,42,19,188,17,522,59,5.15,86817,0,19,3,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;endosome;Golgi;membrane;vacuole,protein binding,"Pf00787, Pf03700, Pf09325, Pf12128",6642,ENSG00000028528.14,SNX1,15,Endocytosis,,,1,High,1
Q13555,Calcium/calmodulin-dependent protein kinase type II subunit gamma OS=Homo sapiens OX=9606 GN=CAMK2G PE=1 SV=4,0,133.308,31,17,411,4,558,62.6,7.83,212498,2.03,17,2,,,,,,,,,,,,0,High,1
Q8IUE6,Histone H2A type 2-B OS=Homo sapiens OX=9606 GN=HIST2H2AB PE=1 SV=3,0,133.163,53,14,939,2,130,14,10.89,500587,,14,,regulation of biological process,chromosome;nucleus,DNA binding;protein binding,"Pf00125, Pf00808",317772,ENSG00000184270.4,HIST2H2AB,1,Alcoholism; Systemic lupus erythematosus,,HDACs deacetylate histones; HATs acetylate histones; UCH proteinases; Ub-specific processing proteases; RMTs methylate histone arginines; Metalloprotease DUBs,13,High,1
O95563,Mitochondrial pyruvate carrier 2 OS=Homo sapiens OX=9606 GN=MPC2 PE=1 SV=1,0,133.106,57,14,1360,14,127,14.3,10.43,724675,1.8,14,3,regulation of biological process;transport,membrane;mitochondrion;nucleus,transporter activity,Pf03650,25874,ENSG00000143158.10,MPC2,1,,Glycolysis and Gluconeogenesis,Pyruvate metabolism,5,High,1
P02765,Alpha-2-HS-glycoprotein OS=Homo sapiens OX=9606 GN=AHSG PE=1 SV=2,0,133.097,19,11,447,11,367,39.3,5.72,209087,5.14,10,1,,,,,,,,,,,,0,High,1
Q15642,Cdc42-interacting protein 4 OS=Homo sapiens OX=9606 GN=TRIP10 PE=1 SV=3,0,133.054,38,16,97,16,601,68.3,5.73,46256,,16,,cell communication;cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;Golgi;membrane;vacuole,enzyme regulator activity;protein binding,"Pf00018, Pf00611, Pf07653, Pf08239, Pf14604",9322,ENSG00000125733.17,TRIP10,19,Insulin signaling pathway,Angiopoietin Like Protein 8 Regulatory Pathway,Rho GTPase cycle; Clathrin-mediated endocytosis,8,High,1
O00423,Echinoderm microtubule-associated protein-like 1 OS=Homo sapiens OX=9606 GN=EML1 PE=1 SV=3,0,132.871,30,20,239,19,815,89.8,7.06,101153,14.11,18,2,cell differentiation;cell organization and biogenesis;cell proliferation,cytoplasm;cytoskeleton;cytosol,metal ion binding;protein binding,"Pf00400, Pf03451",2009,ENSG00000066629.16,EML1,14,,,,0,High,1
P50579,Methionine aminopeptidase 2 OS=Homo sapiens OX=9606 GN=METAP2 PE=1 SV=1,0,132.818,37,14,108,3,478,52.9,5.82,44964,0,14,1,metabolic process;regulation of biological process,cytoplasm;cytosol;membrane,catalytic activity;metal ion binding;RNA binding,Pf00557,10988,ENSG00000111142.13,METAP2,12,,,"Signaling by GPCR; Inactivation, recovery and regulation of the phototransduction cascade",5,High,1
O15020,"Spectrin beta chain, non-erythrocytic 2 OS=Homo sapiens OX=9606 GN=SPTBN2 PE=1 SV=3",0,132.6,6,13,361,3,2390,271.2,6.11,176602,0,13,3,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane,protein binding;structural molecule activity,"Pf00169, Pf00307, Pf00435, Pf11971, Pf12128, Pf15410",6712,ENSG00000173898.11,SPTBN2,11,,,Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; MHC class II antigen presentation; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interleukin-20 family signaling,23,High,1
Q9H078-2,Isoform 2 of Caseinolytic peptidase B protein homolog OS=Homo sapiens OX=9606 GN=CLPB,0,132.539,36,17,144,17,677,75.4,9.01,63832,22.15,16,2,response to stimulus,mitochondrion,catalytic activity;nucleotide binding;protein binding,"Pf00004, Pf00023, Pf06309, Pf06414, Pf07724, Pf07728, Pf10431, Pf12796, Pf13401, Pf13606, Pf13637, Pf13857",81570,ENSG00000162129.12,CLPB,11,,,,0,High,1
Q16718,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 OS=Homo sapiens OX=9606 GN=NDUFA5 PE=1 SV=3,0,132.354,70,10,783,10,116,13.5,5.99,397001,32.46,9,3,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion,catalytic activity;protein binding,Pf04716,4698,ENSG00000128609.14,NDUFA5,7,Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Huntington's disease; Metabolic pathways; Parkinson's disease,Electron Transport Chain; Oxidative phosphorylation,Complex I biogenesis,13,High,1
Q9C0C2,182 kDa tankyrase-1-binding protein OS=Homo sapiens OX=9606 GN=TNKS1BP1 PE=1 SV=4,0,132.251,24,26,158,26,1729,181.7,4.86,66697,2.61,25,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;cytoskeleton;cytosol;nucleus,protein binding,Pf15327,85456,ENSG00000149115.13,TNKS1BP1,11,,,TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Deadenylation of mRNA,9,High,1
Q9ULH0,Kinase D-interacting substrate of 220 kDa OS=Homo sapiens OX=9606 GN=KIDINS220 PE=1 SV=3,0,132.221,18,26,106,26,1771,196.4,6.62,43246,8.58,25,1,cell organization and biogenesis;regulation of biological process;response to stimulus,cytosol;endosome;membrane,enzyme regulator activity;protein binding,"Pf00023, Pf07693, Pf12796, Pf13606, Pf13637, Pf13857",57498,ENSG00000134313.15,KIDINS220,2,Neurotrophin signaling pathway,Brain-Derived Neurotrophic Factor (BDNF) signaling pathway,ARMS-mediated activation,9,High,1
Q14839,Chromodomain-helicase-DNA-binding protein 4 OS=Homo sapiens OX=9606 GN=CHD4 PE=1 SV=2,0,132.144,19,29,103,29,1912,217.9,5.86,37388,0,29,2,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytoskeleton;membrane;nucleus,catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding,"Pf00176, Pf00271, Pf00385, Pf00628, Pf04851, Pf06461, Pf06465, Pf08073, Pf08074, Pf13831",1108,ENSG00000111642.14,CHD4,12,Viral carcinogenesis,,ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation,21,High,1
P35052,Glypican-1 OS=Homo sapiens OX=9606 GN=GPC1 PE=1 SV=2,0,132.101,35,14,132,14,558,61.6,7.3,62002,0,14,3,cell differentiation;cellular component movement;metabolic process;regulation of biological process,cytosol;endosome;extracellular;membrane;organelle lumen,metal ion binding;protein binding,Pf01153,2817,ENSG00000063660.8,GPC1,2,Proteoglycans in cancer,VEGFA-VEGFR2 Signaling Pathway,"Defective B4GALT7 causes EDS, progeroid type; Retinoid metabolism and transport; Defective EXT2 causes exostoses 2; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Signaling by GPCR; HS-GAG biosynthesis; A tetrasaccharide linker sequence is required for GAG synthesis; Signaling by ROBO receptors; Cell surface interactions at the vascular wall; Defective B3GALT6 causes EDSP2 and SEMDJL1; HS-GAG degradation; Defective B3GAT3 causes JDSSDHD",29,High,1
Q16401,26S proteasome non-ATPase regulatory subunit 5 OS=Homo sapiens OX=9606 GN=PSMD5 PE=1 SV=3,0,131.937,37,15,150,15,504,56.2,5.48,84316,0,15,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;proteasome,protein binding,Pf10508,5711,ENSG00000095261.13,PSMD5,9,,Proteasome Degradation; Parkin-Ubiquitin Proteasomal System pathway,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,150,High,1
Q5T440,"Putative transferase CAF17, mitochondrial OS=Homo sapiens OX=9606 GN=IBA57 PE=1 SV=1",0,131.787,48,12,224,12,356,38.1,9.83,110282,12.97,12,3,cell organization and biogenesis;metabolic process,mitochondrion;organelle lumen,catalytic activity;RNA binding,"Pf01571, Pf08669",200205,ENSG00000181873.12,IBA57,1,,,,0,High,1
Q13505,Metaxin-1 OS=Homo sapiens OX=9606 GN=MTX1 PE=1 SV=3,0,131.754,28,13,191,13,466,51.4,9.79,90908,0,13,1,,,,,,,,,,,,0,High,1
Q9H3G5,Probable serine carboxypeptidase CPVL OS=Homo sapiens OX=9606 GN=CPVL PE=1 SV=2,0,131.671,26,16,298,16,476,54.1,5.62,138006,,16,,metabolic process,,catalytic activity,Pf00450,54504,ENSG00000106066.14,CPVL,7,,,,0,High,1
P62424,60S ribosomal protein L7a OS=Homo sapiens OX=9606 GN=RPL7A PE=1 SV=2,0,131.53,39,14,591,14,266,30,10.61,295867,6.9,13,4,cell organization and biogenesis;metabolic process;transport,cytoplasm;cytosol;membrane;nucleus;ribosome,protein binding;RNA binding;structural molecule activity,Pf01248,6130,ENSG00000280858.2; ENSG00000148303.16,RPL7A,9; CHR_HG2030_PATCH,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
P30711,Glutathione S-transferase theta-1 OS=Homo sapiens OX=9606 GN=GSTT1 PE=1 SV=4,0,131.489,42,12,277,12,240,27.3,7.49,127256,0,12,1,metabolic process,cytoplasm;cytosol,antioxidant activity;catalytic activity;protein binding,"Pf00043, Pf02798, Pf13409, Pf13417",2952,ENSG00000277656.3,GSTT1,22; CHR_HSCHR22_1_CTG7,Chemical carcinogenesis; Metabolism of xenobiotics by cytochrome P450; Platinum drug resistance; Drug metabolism - cytochrome P450; Glutathione metabolism,Glutathione metabolism; NRF2 pathway; Aflatoxin B1 metabolism; Metapathway biotransformation,Glutathione conjugation,13,High,1
Q9NVS9,Pyridoxine-5'-phosphate oxidase OS=Homo sapiens OX=9606 GN=PNPO PE=1 SV=1,0,131.272,42,11,174,11,261,30,7.06,79024,,11,,metabolic process,cytosol,catalytic activity;nucleotide binding;protein binding,"Pf01243, Pf10590, Pf12766",55163,ENSG00000108439.9,PNPO,17,Vitamin B6 metabolism; Metabolic pathways,Selenium Micronutrient Network,Vitamins B6 activation to pyridoxal phosphate,7,High,1
Q9UKU7,"Isobutyryl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACAD8 PE=1 SV=1",0,131.204,35,14,258,14,415,45,7.85,118860,37.41,14,2,metabolic process;regulation of biological process,mitochondrion;organelle lumen,catalytic activity;nucleotide binding,"Pf00441, Pf02770, Pf02771, Pf08028",27034,ENSG00000151498.11,ACAD8,11,"Valine, leucine and isoleucine degradation; Metabolic pathways",,Branched-chain amino acid catabolism,5,High,1
Q9Y371,Endophilin-B1 OS=Homo sapiens OX=9606 GN=SH3GLB1 PE=1 SV=1,0,131.112,37,14,172,13,365,40.8,6.04,90429,,14,,cell communication;cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;Golgi;membrane;mitochondrion,protein binding,"Pf00018, Pf03114, Pf07653, Pf14604",51100,ENSG00000097033.14,SH3GLB1,1,Endocytosis,Nanoparticle triggered autophagic cell death; Senescence and Autophagy in Cancer,,3,High,1
Q9BX68,"Histidine triad nucleotide-binding protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=HINT2 PE=1 SV=1",0,131.094,65,11,357,11,163,17.2,9.16,189349,4.93,10,2,cell death;metabolic process;regulation of biological process,mitochondrion,catalytic activity;nucleotide binding,"Pf01230, Pf11969",84681,ENSG00000137133.10,HINT2,9,,,,0,High,1
P23284,Peptidyl-prolyl cis-trans isomerase B OS=Homo sapiens OX=9606 GN=PPIB PE=1 SV=2,0,130.953,53,16,549,15,216,23.7,9.41,270194,,16,,metabolic process;regulation of biological process,endoplasmic reticulum;membrane;nucleus;organelle lumen,catalytic activity;protein binding;RNA binding,Pf00160,5479,ENSG00000166794.4,PPIB,15,,Prolactin Signaling Pathway,Collagen biosynthesis and modifying enzymes,4,High,1
Q96G03,Phosphoglucomutase-2 OS=Homo sapiens OX=9606 GN=PGM2 PE=1 SV=4,0,130.851,31,18,149,18,612,68.2,6.73,64866,2.1,18,3,metabolic process;transport,cytoplasm;cytosol;extracellular;organelle lumen,catalytic activity;metal ion binding;protein binding,"Pf00408, Pf02878, Pf02879, Pf02880",55276,ENSG00000169299.13,PGM2,4,Amino sugar and nucleotide sugar metabolism; Purine metabolism; Pentose phosphate pathway; Galactose metabolism; Metabolic pathways; Glycolysis / Gluconeogenesis; Starch and sucrose metabolism,Glucuronidation,Neutrophil degranulation; Galactose catabolism; Glycogen breakdown (glycogenolysis); Glycogen synthesis; Pentose phosphate pathway (hexose monophosphate shunt),18,High,1
Q15459,Splicing factor 3A subunit 1 OS=Homo sapiens OX=9606 GN=SF3A1 PE=1 SV=1,0,130.845,30,19,107,19,793,88.8,5.22,46969,,19,,cell organization and biogenesis;metabolic process;regulation of biological process,nucleus;spliceosomal complex,protein binding;RNA binding,"Pf00240, Pf01805, Pf12230, Pf14560",10291,ENSG00000099995.18,SF3A1,22,Spliceosome,mRNA Processing,mRNA Splicing - Major Pathway,6,High,1
Q7L7L0,Histone H2A type 3 OS=Homo sapiens OX=9606 GN=HIST3H2A PE=1 SV=3,0,130.793,56,15,2116,1,130,14.1,11.05,1148968,0,15,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;nucleus,DNA binding;protein binding,"Pf00125, Pf00808",92815,ENSG00000181218.5,HIST3H2A,1,Systemic lupus erythematosus; Alcoholism,,HDACs deacetylate histones; HATs acetylate histones; UCH proteinases; Ub-specific processing proteases; RMTs methylate histone arginines; Metalloprotease DUBs,13,High,1
P53814,Smoothelin OS=Homo sapiens OX=9606 GN=SMTN PE=1 SV=7,0,130.771,24,18,130,18,917,99,9.07,61025,,18,,,cytoplasm;cytoskeleton,protein binding;structural molecule activity,"Pf00307, Pf11971, Pf12510",6525,ENSG00000183963.18,SMTN,22,,,,0,High,1
Q9UDY4,DnaJ homolog subfamily B member 4 OS=Homo sapiens OX=9606 GN=DNAJB4 PE=1 SV=1,0,130.696,31,14,301,14,337,37.8,8.5,130234,73.85,11,5,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,enzyme regulator activity;protein binding,"Pf00226, Pf01556",11080,ENSG00000162616.8,DNAJB4,1,,,,0,High,1
P30085,UMP-CMP kinase OS=Homo sapiens OX=9606 GN=CMPK1 PE=1 SV=3,0,130.552,54,13,303,13,196,22.2,5.57,138807,0,13,3,metabolic process,cytoplasm;cytosol;nucleus,catalytic activity;nucleotide binding,"Pf00406, Pf02223, Pf13207, Pf13238, Pf13521, Pf13671",51727,,CMPK1,1,Pyrimidine metabolism; Metabolic pathways,,Interconversion of nucleotide di- and triphosphates,5,High,1
Q9NQC3-5,Isoform B2 of Reticulon-4 OS=Homo sapiens OX=9606 GN=RTN4,0,130.464,52,14,163,1,392,42.2,4.74,82390,10.85,12,2,cell death;cell organization and biogenesis;cellular component movement;regulation of biological process,endoplasmic reticulum;membrane,protein binding;RNA binding,Pf02453,57142,ENSG00000115310.17,RTN4,2,,Spinal Cord Injury,,1,High,1
P46020,"Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform OS=Homo sapiens OX=9606 GN=PHKA1 PE=1 SV=2",0,130.392,23,22,146,20,1223,137.2,6.19,65032,11.27,19,4,metabolic process,cytosol;membrane,catalytic activity;protein binding,Pf00723,5255,ENSG00000067177.14,PHKA1,X,Calcium signaling pathway; Insulin signaling pathway; Glucagon signaling pathway,Glycogen Metabolism,Glycogen breakdown (glycogenolysis),8,High,1
P46108,Adapter molecule crk OS=Homo sapiens OX=9606 GN=CRK PE=1 SV=2,0,130.327,57,14,183,14,304,33.8,5.55,96148,0,14,1,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,protein binding,"Pf00017, Pf00018, Pf07653, Pf14604",1398,ENSG00000167193.7,CRK,17,ErbB signaling pathway; Shigellosis; Rap1 signaling pathway; Fc gamma R-mediated phagocytosis; MicroRNAs in cancer; Focal adhesion; Pathways in cancer; MAPK signaling pathway; Chemokine signaling pathway; Neurotrophin signaling pathway; Bacterial invasion of epithelial cells; Insulin signaling pathway; Renal cell carcinoma; Chronic myeloid leukemia; Regulation of actin cytoskeleton,Integrin-mediated Cell Adhesion; B Cell Receptor Signaling Pathway; Kit receptor signaling pathway; Focal Adhesion; Signaling of Hepatocyte Growth Factor Receptor; Rac1/Pak1/p38/MMP-2 pathway; MAPK Signaling Pathway; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; Chemokine signaling pathway; EGF/EGFR Signaling Pathway; Insulin Signaling; Regulation of Actin Cytoskeleton; Interferon type I signaling pathways; ErbB Signaling Pathway; T-Cell antigen Receptor (TCR)  Signaling Pathway,"VEGFA-VEGFR2 Pathway; ARMS-mediated activation; MET activates RAP1 and RAC1; Downstream signal transduction; p130Cas linkage to MAPK signaling for integrins; MET receptor recycling; Regulation of signaling by CBL; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; Regulation of actin dynamics for phagocytic cup formation",63,High,1
Q96AE4,Far upstream element-binding protein 1 OS=Homo sapiens OX=9606 GN=FUBP1 PE=1 SV=3,0,130.216,39,19,161,16,644,67.5,7.61,72731,0,19,1,metabolic process;regulation of biological process,nucleus,DNA binding;protein binding;RNA binding,"Pf00013, Pf07650, Pf13014",8880,ENSG00000162613.16,FUBP1,1,,,,0,High,1
Q8N163,Cell cycle and apoptosis regulator protein 2 OS=Homo sapiens OX=9606 GN=CCAR2 PE=1 SV=2,0,130.207,38,21,113,21,923,102.8,5.22,47279,,21,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus;organelle lumen;spliceosomal complex,enzyme regulator activity;protein binding;RNA binding,"Pf14443, Pf14444",57805,ENSG00000158941.16,CCAR2; KIAA1967,8,,,Regulation of HSF1-mediated heat shock response,4,High,1
P30405,"Peptidyl-prolyl cis-trans isomerase F, mitochondrial OS=Homo sapiens OX=9606 GN=PPIF PE=1 SV=1",0,130.173,58,10,444,9,207,22,9.38,209679,143.9,8,3,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,membrane;mitochondrion;organelle lumen,catalytic activity;protein binding,Pf00160,10105,ENSG00000108179.13,PPIF,10,Parkinson's disease; cGMP-PKG signaling pathway; Calcium signaling pathway; Huntington's disease; Toxoplasmosis,,,5,High,1
P42126,"Enoyl-CoA delta isomerase 1, mitochondrial OS=Homo sapiens OX=9606 GN=ECI1 PE=1 SV=1",0,130.17,37,13,655,13,302,32.8,8.54,315110,17.96,12,4,metabolic process,membrane;mitochondrion;organelle lumen,catalytic activity,Pf00378,1632,ENSG00000167969.12,ECI1,16,Fatty acid degradation,Fatty Acid Beta Oxidation; Mitochondrial LC-Fatty Acid Beta-Oxidation,mitochondrial fatty acid beta-oxidation of unsaturated fatty acids,8,High,1
O94905,Erlin-2 OS=Homo sapiens OX=9606 GN=ERLIN2 PE=1 SV=1,0,130.126,53,15,236,13,339,37.8,5.62,103810,2.28,15,1,metabolic process;regulation of biological process;response to stimulus;transport,cytosol;endoplasmic reticulum;membrane,catalytic activity;protein binding,Pf01145,11160,ENSG00000147475.14,ERLIN2,8,,,ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Signaling by plasma membrane FGFR1 fusions,11,High,1
O60826,Coiled-coil domain-containing protein 22 OS=Homo sapiens OX=9606 GN=CCDC22 PE=1 SV=1,0,130.041,35,20,141,20,627,70.7,6.74,59897,0,20,1,cellular homeostasis;metabolic process;regulation of biological process;transport,cytosol;endosome,protein binding,Pf05667,28952,ENSG00000101997.12,CCDC22,X,,,Neddylation,3,High,1
O43181,"NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS4 PE=1 SV=1",0,129.878,53,14,606,14,175,20.1,10.3,292629,31.81,13,5,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,membrane;mitochondrion,catalytic activity,Pf04800,4724,ENSG00000164258.11,NDUFS4,5,Alzheimer's disease; Non-alcoholic fatty liver disease (NAFLD); Parkinson's disease; Metabolic pathways; Oxidative phosphorylation; Huntington's disease,Electron Transport Chain; Oxidative phosphorylation,Complex I biogenesis,13,High,1
Q9NXA8,"NAD-dependent protein deacylase sirtuin-5, mitochondrial OS=Homo sapiens OX=9606 GN=SIRT5 PE=1 SV=2",0,129.852,34,9,238,9,310,33.9,8.47,121096,8.22,9,2,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;mitochondrion;nucleus;organelle lumen,catalytic activity;metal ion binding;nucleotide binding,"Pf02146, Pf02233",23408,ENSG00000124523.15,SIRT5,6,,NAD+ metabolism; NAD+ biosynthetic pathways,Transcriptional activation of mitochondrial biogenesis,5,High,1
P20042,Eukaryotic translation initiation factor 2 subunit 2 OS=Homo sapiens OX=9606 GN=EIF2S2 PE=1 SV=2,0,129.833,50,19,232,19,333,38.4,5.8,109882,,19,,cell proliferation;metabolic process;transport,cytoplasm;cytosol;nucleus,metal ion binding;protein binding;RNA binding,"Pf01873, Pf04147",8894,ENSG00000125977.6,EIF2S2,20,RNA transport,Translation Factors; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway,"Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; ABC-family proteins mediated transport; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Recycling of eIF2:GDP; Ribosomal scanning and start codon recognition",16,High,1
Q9GZY8,Mitochondrial fission factor OS=Homo sapiens OX=9606 GN=MFF PE=1 SV=1,0,129.714,47,12,145,12,342,38.4,8.95,64711,0,12,1,cell organization and biogenesis;regulation of biological process;transport,membrane;mitochondrion,protein binding,Pf05644,56947,ENSG00000168958.19,MFF,2,,,,0,High,1
Q15477,Helicase SKI2W OS=Homo sapiens OX=9606 GN=SKIV2L PE=1 SV=3,0,129.63,27,24,106,24,1246,137.7,6.06,45397,,24,,metabolic process,cytoplasm;cytosol;nucleus,catalytic activity;nucleotide binding;RNA binding,"Pf00270, Pf00271, Pf08148, Pf13234",6499,ENSG00000204351.11; ENSG00000225737.9,SKIV2L,6; CHR_HSCHR6_MHC_COX_CTG1,RNA degradation,,mRNA decay by 3' to 5' exoribonuclease; Association of TriC/CCT with target proteins during biosynthesis,8,High,1
Q9UHX1-2,Isoform 2 of Poly(U)-binding-splicing factor PUF60 OS=Homo sapiens OX=9606 GN=PUF60,0,129.572,45,16,99,16,542,58.1,5.35,41173,14.68,15,1,cell death;metabolic process;regulation of biological process,,DNA binding;protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",22827,ENSG00000274081.4; ENSG00000179950.13,PUF60,8; CHR_HSCHR8_3_CTG7,,,,0,High,1
P08697,Alpha-2-antiplasmin OS=Homo sapiens OX=9606 GN=SERPINF2 PE=1 SV=3,0,129.544,33,14,163,14,491,54.5,6.29,80858,,14,,cell organization and biogenesis;defense response;regulation of biological process;response to stimulus;transport,cell surface;extracellular;organelle lumen,enzyme regulator activity;protein binding,Pf00079,5345,ENSG00000167711.13,SERPINF2,17,Complement and coagulation cascades,Blood Clotting Cascade; Complement and Coagulation Cascades,Platelet degranulation ; Dissolution of Fibrin Clot,8,High,1
P49589,"Cysteine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=CARS PE=1 SV=3",0,129.402,31,21,110,21,748,85.4,6.76,48577,,21,,metabolic process,cytoplasm;cytosol,catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding,"Pf01406, Pf09334",833,ENSG00000278191.4; ENSG00000110619.17,CARS,11; CHR_HSCHR11_1_CTG7,Aminoacyl-tRNA biosynthesis,,Cytosolic tRNA aminoacylation,5,High,1
Q9BWM7,Sideroflexin-3 OS=Homo sapiens OX=9606 GN=SFXN3 PE=1 SV=3,0,129.203,57,16,187,14,321,35.5,9.1,84573,,16,,transport,membrane;mitochondrion,transporter activity,Pf03820,81855,ENSG00000107819.13,SFXN3,10,,,,0,High,1
Q9Y6E2,Basic leucine zipper and W2 domain-containing protein 2 OS=Homo sapiens OX=9606 GN=BZW2 PE=1 SV=1,0,129.1,42,20,304,17,419,48.1,6.68,143745,0,19,1,cell differentiation;development,cytoplasm;membrane,protein binding,Pf02020,28969,ENSG00000136261.14,BZW2,7,,,,0,High,1
P32189-1,Isoform 1 of Glycerol kinase OS=Homo sapiens OX=9606 GN=GK,0,129.041,35,16,308,16,524,57.5,6.32,134387,0,16,1,metabolic process,cytosol;membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding,"Pf00370, Pf02782",2710,ENSG00000198814.12,GK,X,,Fatty Acid Beta Oxidation; Type II diabetes mellitus; Triacylglyceride Synthesis,,3,High,1
Q9BSH5,Haloacid dehalogenase-like hydrolase domain-containing protein 3 OS=Homo sapiens OX=9606 GN=HDHD3 PE=1 SV=1,0,128.914,50,13,191,13,251,28,6.71,96678,0,13,1,metabolic process,mitochondrion,catalytic activity;protein binding,"Pf00702, Pf13242, Pf13419",81932,ENSG00000119431.9,HDHD3,9,,,,0,High,1
P61247,40S ribosomal protein S3a OS=Homo sapiens OX=9606 GN=RPS3A PE=1 SV=2,0,128.87,47,17,409,17,264,29.9,9.73,171690,0,17,2,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;endoplasmic reticulum;nucleus;ribosome,protein binding;RNA binding;structural molecule activity,Pf01015,6189,ENSG00000145425.9,RPS3A,4,Ribosome,Cytoplasmic Ribosomal Proteins,"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane",38,High,1
Q9NUU7,ATP-dependent RNA helicase DDX19A OS=Homo sapiens OX=9606 GN=DDX19A PE=1 SV=1,0,128.826,48,19,135,4,478,53.9,6.58,57854,8.74,19,1,metabolic process;regulation of biological process;transport,cytoplasm;membrane;nucleus;spliceosomal complex,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00270, Pf00271",55308,ENSG00000168872.16,DDX19A,16,,,,0,High,1
Q04837,"Single-stranded DNA-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=SSBP1 PE=1 SV=1",0,128.722,70,14,383,14,148,17.2,9.6,195267,1.81,14,2,cell organization and biogenesis;metabolic process;regulation of biological process,mitochondrion;nucleus;organelle lumen,DNA binding;protein binding;RNA binding,Pf00436,6742,ENSG00000106028.10,SSBP1,7,DNA replication; Mismatch repair; Homologous recombination,,Transcriptional activation of mitochondrial biogenesis,6,High,1
Q6JQN1,Acyl-CoA dehydrogenase family member 10 OS=Homo sapiens OX=9606 GN=ACAD10 PE=1 SV=1,0,128.621,29,22,271,22,1059,118.8,8.06,112977,7.01,21,2,metabolic process,mitochondrion;organelle lumen,catalytic activity;nucleotide binding,"Pf00441, Pf00702, Pf01163, Pf01636, Pf02770, Pf02771, Pf08028, Pf13242, Pf13419",80724,ENSG00000111271.14,ACAD10,12,,,Mitochondrial Fatty Acid Beta-Oxidation,4,High,1
Q00577,Transcriptional activator protein Pur-alpha OS=Homo sapiens OX=9606 GN=PURA PE=1 SV=2,0,128.621,36,11,321,10,322,34.9,6.44,143867,0,11,1,cell differentiation;metabolic process;regulation of biological process,cytoplasm;nucleus,DNA binding;protein binding;RNA binding;translation regulator activity,Pf04845,5813,ENSG00000185129.5,PURA,5,,Exercise-induced Circadian Regulation,,1,High,1
P51589,Cytochrome P450 2J2 OS=Homo sapiens OX=9606 GN=CYP2J2 PE=1 SV=2,0,128.558,44,20,138,19,502,57.6,8.6,63914,23.3,17,3,metabolic process;regulation of biological process,endoplasmic reticulum;membrane,catalytic activity;metal ion binding,Pf00067,1573,ENSG00000134716.9,CYP2J2,1,Arachidonic acid metabolism; Metabolic pathways; Serotonergic synapse; Linoleic acid metabolism; Ovarian steroidogenesis; Inflammatory mediator regulation of TRP channels,Oxidation by Cytochrome P450; Tryptophan metabolism; Arachidonate Epoxygenase / Epoxide Hydrolase; Metapathway biotransformation,Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET); Fatty acids; Xenobiotics,20,High,1
O43464,"Serine protease HTRA2, mitochondrial OS=Homo sapiens OX=9606 GN=HTRA2 PE=1 SV=2",0,128.497,43,16,162,15,458,48.8,10.07,71540,2.84,16,1,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoskeleton;cytosol;endoplasmic reticulum;membrane;mitochondrion;nucleus,catalytic activity;protein binding,"Pf00089, Pf00595, Pf04495, Pf10459, Pf13180, Pf13365",27429,ENSG00000115317.11,HTRA2,2,Parkinson's disease; Apoptosis - multiple species; Apoptosis,Parkinsons Disease Pathway; Nanomaterial induced apoptosis,,5,High,1
P25786,Proteasome subunit alpha type-1 OS=Homo sapiens OX=9606 GN=PSMA1 PE=1 SV=1,0,128.441,43,12,512,12,263,29.5,6.61,256318,0,12,1,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus;proteasome,catalytic activity;protein binding;RNA binding,"Pf00227, Pf10584",5682,ENSG00000129084.17,PSMA1,11,Proteasome,Proteasome Degradation,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,150,High,1
P21266,Glutathione S-transferase Mu 3 OS=Homo sapiens OX=9606 GN=GSTM3 PE=1 SV=3,0,128.321,64,16,476,13,225,26.5,5.54,242390,25.95,13,4,metabolic process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,"Pf00043, Pf02798, Pf14497",2947,ENSG00000134202.10,GSTM3,1,Chemical carcinogenesis; Glutathione metabolism; Platinum drug resistance; Metabolism of xenobiotics by cytochrome P450; Drug metabolism - cytochrome P450,NRF2 pathway; Exercise-induced Circadian Regulation; Metapathway biotransformation,Glutathione conjugation,12,High,1
Q08J23,RNA cytosine C(5)-methyltransferase NSUN2 OS=Homo sapiens OX=9606 GN=NSUN2 PE=1 SV=2,0,128.127,36,19,95,19,767,86.4,6.77,45993,,19,,cell division;metabolic process,cytoplasm;cytoskeleton;nucleus,catalytic activity;RNA binding,"Pf01189, Pf13659",54888,ENSG00000037474.14,NSUN2,5,,,tRNA modification in the nucleus and cytosol,3,High,1
Q8NBS9,Thioredoxin domain-containing protein 5 OS=Homo sapiens OX=9606 GN=TXNDC5 PE=1 SV=2,0,128.055,48,18,305,18,432,47.6,5.97,145761,7.21,17,2,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;extracellular;organelle lumen,catalytic activity;protein binding,"Pf00085, Pf13098, Pf13905",81567,ENSG00000239264.8,TXNDC5,6,Protein processing in endoplasmic reticulum,,Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis,10,High,1
Q5U651,Ras-interacting protein 1 OS=Homo sapiens OX=9606 GN=RASIP1 PE=1 SV=1,0,128.024,36,21,149,21,963,103.4,7.96,64397,0,21,2,cell differentiation;regulation of biological process;response to stimulus,cytoplasm;Golgi,protein binding,"Pf00788, Pf01843",54922,ENSG00000105538.9,RASIP1,19,,,,0,High,1
Q8NCA5,Protein FAM98A OS=Homo sapiens OX=9606 GN=FAM98A PE=1 SV=2,0,127.885,25,12,244,10,518,55.2,8.95,106377,0,12,1,,,,,,,,,,,,0,High,1
P51812,Ribosomal protein S6 kinase alpha-3 OS=Homo sapiens OX=9606 GN=RPS6KA3 PE=1 SV=1,0,127.644,33,19,156,14,740,83.7,6.89,62217,4.97,18,3,cell death;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf00433, Pf07714, Pf14531",6197,ENSG00000177189.12,RPS6KA3,X,MAPK signaling pathway; Oocyte meiosis; Neurotrophin signaling pathway; Long-term potentiation; Progesterone-mediated oocyte maturation; Insulin resistance; mTOR signaling pathway,Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Kit receptor signaling pathway; MAPK Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; EGF/EGFR Signaling Pathway; Cytoplasmic Ribosomal Proteins; Insulin Signaling,CREB phosphorylation; ERK/MAPK targets; Recycling pathway of L1; Activated TLR4 signalling; Signaling by GPCR; Gastrin-CREB signalling pathway via PKC and MAPK; Senescence-Associated Secretory Phenotype (SASP); RSK activation,62,High,1
Q9BZF9,Uveal autoantigen with coiled-coil domains and ankyrin repeats OS=Homo sapiens OX=9606 GN=UACA PE=1 SV=2,0,127.601,24,26,119,26,1416,162.4,7.03,44056,,26,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;extracellular;nucleus,protein binding,"Pf00023, Pf04111, Pf07888, Pf09726, Pf10174, Pf12128, Pf12796, Pf13606, Pf13637, Pf13857",55075,ENSG00000137831.14,UACA,15,,,,0,High,1
Q9NUT2,Mitochondrial potassium channel ATP-binding subunit OS=Homo sapiens OX=9606 GN=ABCB8 PE=1 SV=3,0,127.58,35,21,216,20,735,79.9,8.98,98742,0,21,2,transport,membrane;mitochondrion;nucleus,catalytic activity;nucleotide binding;transporter activity,"Pf00005, Pf00664, Pf06414, Pf13304, Pf13481, Pf13558",11194,ENSG00000197150.12,ABCB8,7,ABC transporters,,Mitochondrial ABC transporters,4,High,1
Q05086,Ubiquitin-protein ligase E3A OS=Homo sapiens OX=9606 GN=UBE3A PE=1 SV=4,0,127.505,28,20,113,20,875,100.6,5.22,55678,2.58,19,3,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus;proteasome,catalytic activity;metal ion binding;protein binding;transporter activity,Pf00632,7337,ENSG00000114062.18,UBE3A,15,Ubiquitin mediated proteolysis; Viral carcinogenesis,Androgen receptor signaling pathway; Mecp2 and Associated Rett Syndrome; Tryptophan metabolism,Antigen processing: Ubiquitination & Proteasome degradation,9,High,1
Q02487,Desmocollin-2 OS=Homo sapiens OX=9606 GN=DSC2 PE=1 SV=1,0,127.302,19,12,105,11,901,99.9,5.34,47750,1.83,12,1,cell communication;cell death;regulation of biological process;response to stimulus,cytoskeleton;membrane,metal ion binding;protein binding,"Pf00028, Pf01049, Pf08758",1824,ENSG00000134755.14,DSC2,18,Arrhythmogenic right ventricular cardiomyopathy (ARVC),Arrhythmogenic Right Ventricular Cardiomyopathy,Formation of the cornified envelope,5,High,1
Q15555,Microtubule-associated protein RP/EB family member 2 OS=Homo sapiens OX=9606 GN=MAPRE2 PE=1 SV=1,0,127.152,57,17,233,14,327,37,5.57,99031,0,17,2,cell division;cell proliferation;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton,protein binding,"Pf00307, Pf03271",10982,ENSG00000166974.12,MAPRE2,18,,,,0,High,1
P82650,"28S ribosomal protein S22, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS22 PE=1 SV=1",0,127.047,45,15,312,15,360,41.3,7.9,137499,0,15,2,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,structural molecule activity,Pf10245,56945,ENSG00000175110.11,MRPS22,3,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
Q13492,Phosphatidylinositol-binding clathrin assembly protein OS=Homo sapiens OX=9606 GN=PICALM PE=1 SV=2,0,127.03,39,18,200,16,652,70.7,7.9,93212,0,18,1,cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytosol;endosome;Golgi;membrane;nucleus,protein binding,"Pf01417, Pf07651",8301,ENSG00000073921.17,PICALM,11,,,Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis,7,High,1
Q9Y5S2,Serine/threonine-protein kinase MRCK beta OS=Homo sapiens OX=9606 GN=CDC42BPB PE=1 SV=2,0,126.976,23,27,97,26,1711,194.2,6.37,35757,0,25,3,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;extracellular;Golgi;membrane,catalytic activity;metal ion binding;motor activity;nucleotide binding;protein binding;structural molecule activity,"Pf00038, Pf00069, Pf00130, Pf00261, Pf00433, Pf00769, Pf00780, Pf01442, Pf01576, Pf02463, Pf02841, Pf03148, Pf03938, Pf03962, Pf04012, Pf04111, Pf04156, Pf04849, Pf05010, Pf05103, Pf05276, Pf05483, Pf05557, Pf05622, Pf05667, Pf05701, Pf06008, Pf06160, Pf07227, Pf07321, Pf07714, Pf07767, Pf07851, Pf07888, Pf07926, Pf08614, Pf08826, Pf09726, Pf09728, Pf09730, Pf09731, Pf09789, Pf10168, Pf10174, Pf10368, Pf11855, Pf11932, Pf12037, Pf12072, Pf12128, Pf12795, Pf13166, Pf13476, Pf13514, Pf13851, Pf13863, Pf13868, Pf13870, Pf14643, Pf14644, Pf14817, Pf14915, Pf14992, Pf15066, Pf15070, Pf15294, Pf15369, Pf15397, Pf15558, Pf15619",9578,ENSG00000198752.10,CDC42BPB,14,,,,0,High,1
Q5TC12,ATP synthase mitochondrial F1 complex assembly factor 1 OS=Homo sapiens OX=9606 GN=ATPAF1 PE=1 SV=1,0,126.934,33,10,200,10,328,36.4,7.96,96120,,10,,cell organization and biogenesis,mitochondrion,protein binding,Pf06644,64756,ENSG00000123472.12,ATPAF1,1,,,,0,High,1
O95757,Heat shock 70 kDa protein 4L OS=Homo sapiens OX=9606 GN=HSPA4L PE=1 SV=3,0,126.917,30,17,106,14,839,94.5,5.88,49868,7.49,16,1,metabolic process;response to stimulus,cytoplasm;cytosol;nucleus,nucleotide binding,Pf00012,22824,ENSG00000164070.11,HSPA4L,4,Protein processing in endoplasmic reticulum,,Regulation of HSF1-mediated heat shock response,5,High,1
Q9HAU0,Pleckstrin homology domain-containing family A member 5 OS=Homo sapiens OX=9606 GN=PLEKHA5 PE=1 SV=1,0,126.847,26,20,116,20,1116,127.4,7.53,46229,0,20,1,metabolic process,cytoplasm;cytosol;membrane,protein binding,"Pf00169, Pf00397, Pf04111, Pf15413",54477,ENSG00000052126.14,PLEKHA5,12,,,Synthesis of PIPs at the plasma membrane,5,High,1
P17568,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 OS=Homo sapiens OX=9606 GN=NDUFB7 PE=1 SV=4,0,126.748,41,6,492,6,137,16.4,8.92,235530,19.34,6,2,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion,catalytic activity,Pf05676,4713,ENSG00000099795.6,NDUFB7,19,Oxidative phosphorylation; Metabolic pathways; Parkinson's disease; Non-alcoholic fatty liver disease (NAFLD); Alzheimer's disease; Huntington's disease,Electron Transport Chain; Oxidative phosphorylation,Complex I biogenesis,13,High,1
Q15907,Ras-related protein Rab-11B OS=Homo sapiens OX=9606 GN=RAB11B PE=1 SV=4,0,126.74,59,13,367,13,218,24.5,5.94,177282,2.39,13,2,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf01926, Pf08477, Pf13401",9230,ENSG00000185236.11,RAB11B,19,Endocytosis; Vasopressin-regulated water reabsorption; AMPK signaling pathway,Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,TBC/RABGAPs; RAB geranylgeranylation,11,High,1
Q00796,Sorbitol dehydrogenase OS=Homo sapiens OX=9606 GN=SORD PE=1 SV=4,0,126.731,33,13,357,13,357,38.3,7.97,177782,,13,,cellular component movement;metabolic process;response to stimulus,cytosol;membrane;mitochondrion,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00107, Pf08240, Pf12847",6652,ENSG00000140263.13,SORD,15,Pentose and glucuronate interconversions; Metabolic pathways; Fructose and mannose metabolism,Polyol Pathway,Catabolism of glucuronate to xylulose-5-phosphate; Fructose biosynthesis,9,High,1
P16284,Platelet endothelial cell adhesion molecule OS=Homo sapiens OX=9606 GN=PECAM1 PE=1 SV=2,0,126.469,30,19,128,19,738,82.5,6.99,52646,0,19,2,,,,,,,,,,,,0,High,1
P11171,Protein 4.1 OS=Homo sapiens OX=9606 GN=EPB41 PE=1 SV=4,0,126.352,26,19,121,19,864,97,5.58,50851,,19,,cell division;cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,protein binding;structural molecule activity,"Pf00373, Pf04382, Pf05902, Pf08736, Pf09379, Pf09380",2035,ENSG00000159023.19,EPB41,1,Tight junction,,Neurexins and neuroligins,4,High,1
Q9BYD3,"39S ribosomal protein L4, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL4 PE=1 SV=1",0,126.342,56,11,180,11,311,34.9,9.72,74538,,11,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,protein binding;RNA binding;structural molecule activity,Pf00573,51073,ENSG00000105364.13,MRPL4,19,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
Q9NWU1,"3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial OS=Homo sapiens OX=9606 GN=OXSM PE=1 SV=1",0,126.29,42,12,119,12,459,48.8,7.66,62274,,12,,metabolic process,cytosol;mitochondrion,catalytic activity,"Pf00108, Pf00109, Pf02801",54995,ENSG00000151093.7,OXSM,3,Fatty acid biosynthesis; Metabolic pathways; Fatty acid metabolism; Biotin metabolism,,,4,High,1
P54886,Delta-1-pyrroline-5-carboxylate synthase OS=Homo sapiens OX=9606 GN=ALDH18A1 PE=1 SV=2,0,126.247,33,20,119,20,795,87.2,7.12,48048,,20,,metabolic process,cytoplasm;cytosol;membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00171, Pf00696",5832,ENSG00000059573.8,ALDH18A1,10,Metabolic pathways; Arginine and proline metabolism; Biosynthesis of amino acids,Amino Acid metabolism; Urea cycle and metabolism of amino groups,Amino acid synthesis and interconversion (transamination),8,High,1
Q9NQC3-2,Isoform B of Reticulon-4 OS=Homo sapiens OX=9606 GN=RTN4,0,126.11,52,13,162,1,373,40.3,4.78,81205,20.21,11,2,cell death;cell organization and biogenesis;cellular component movement;regulation of biological process,endoplasmic reticulum;membrane,protein binding;RNA binding,Pf02453,57142,ENSG00000115310.17,RTN4,2,,Spinal Cord Injury,,1,High,1
Q12768,WASH complex subunit 5 OS=Homo sapiens OX=9606 GN=WASHC5 PE=1 SV=1,0,126.074,22,22,141,22,1159,134.2,6.98,59757,0,22,1,cell organization and biogenesis;transport,cytoplasm;cytosol;endoplasmic reticulum;endosome,protein binding,Pf10266,9897,ENSG00000164961.15,KIAA0196; WASHC5,8,Endocytosis,,,1,High,1
Q9NRK6,"ATP-binding cassette sub-family B member 10, mitochondrial OS=Homo sapiens OX=9606 GN=ABCB10 PE=1 SV=2",0,126.026,32,20,143,19,738,79.1,9.85,65031,,20,,transport,membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding;transporter activity,"Pf00005, Pf00664, Pf02463, Pf13304, Pf13481, Pf13558",23456,ENSG00000135776.4,ABCB10,1,ABC transporters,,Mitochondrial ABC transporters,4,High,1
Q13057,Bifunctional coenzyme A synthase OS=Homo sapiens OX=9606 GN=COASY PE=1 SV=4,0,126,41,12,181,12,564,62.3,6.99,89737,0,12,1,metabolic process,cytoplasm;membrane;mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding,"Pf01121, Pf01467, Pf01583, Pf13207, Pf13238, Pf13671",80347,ENSG00000068120.14,COASY,17,Metabolic pathways; Pantothenate and CoA biosynthesis,,Coenzyme A biosynthesis,7,High,1
O75128,Protein cordon-bleu OS=Homo sapiens OX=9606 GN=COBL PE=1 SV=2,0,125.863,15,17,182,17,1261,135.5,7.75,78253,3.13,16,1,cell differentiation;cell growth;cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen,protein binding;RNA binding,Pf09469,23242,ENSG00000106078.17,COBL,7,,,,0,High,1
Q2M3C7,A-kinase anchor protein SPHKAP OS=Homo sapiens OX=9606 GN=SPHKAP PE=1 SV=1,0,125.764,16,16,99,16,1700,186.3,5.14,19502,178.92,2,16,regulation of biological process,cytoplasm;mitochondrion,protein binding,Pf05716,80309,ENSG00000153820.12,SPHKAP,2,,,,0,High,1
O95292,Vesicle-associated membrane protein-associated protein B/C OS=Homo sapiens OX=9606 GN=VAPB PE=1 SV=3,0,125.676,44,12,304,10,243,27.2,7.3,157947,0,12,2,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;Golgi;membrane,protein binding,"Pf00635, Pf00843",9217,ENSG00000124164.15,VAPB,20,,,Sphingolipid de novo biosynthesis,4,High,1
Q92538,Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 OS=Homo sapiens OX=9606 GN=GBF1 PE=1 SV=2,0,125.504,14,18,128,18,1859,206.3,5.73,46423,,18,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;Golgi;membrane;mitochondrion;organelle lumen,protein binding,"Pf01369, Pf12783",8729,ENSG00000107862.4,GBF1,10,Endocytosis,,Clathrin derived vesicle budding; COPI-dependent Golgi-to-ER retrograde traffic; VxPx cargo-targeting to cilium; COPI-mediated anterograde transport,18,High,1
Q5VWZ2,Lysophospholipase-like protein 1 OS=Homo sapiens OX=9606 GN=LYPLAL1 PE=1 SV=3,0,125.394,43,8,482,8,237,26.3,7.84,222478,6.28,8,2,metabolic process,cytoplasm;cytosol,catalytic activity,"Pf01738, Pf02230, Pf12695, Pf12697",127018,ENSG00000143353.11,LYPLAL1,1,,,,0,High,1
P62834,Ras-related protein Rap-1A OS=Homo sapiens OX=9606 GN=RAP1A PE=1 SV=1,0,125.363,48,12,357,2,184,21,6.67,176347,0,12,1,cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane,catalytic activity;nucleotide binding;protein binding;transporter activity,"Pf00009, Pf00071, Pf08477",5906,ENSG00000116473.14,RAP1A,1,Chemokine signaling pathway; Focal adhesion; Long-term potentiation; Neurotrophin signaling pathway; cAMP signaling pathway; Leukocyte transendothelial migration; Renal cell carcinoma; Rap1 signaling pathway; Platelet activation; Ras signaling pathway; Pancreatic secretion; MAPK signaling pathway,Integrin-mediated Cell Adhesion; Integrated Breast Cancer Pathway; Human Thyroid Stimulating Hormone (TSH) signaling pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Common Pathways Underlying Drug Addiction; Focal Adhesion; Signaling of Hepatocyte Growth Factor Receptor; MAPK Signaling Pathway; VEGFA-VEGFR2 Signaling Pathway; Chemokine signaling pathway; EGF/EGFR Signaling Pathway; Interferon type I signaling pathways; Serotonin Receptor 4/6/7 and NR3C Signaling,Signaling by BRAF and RAF fusions; MAP2K and MAPK activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; ARMS-mediated activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; MET activates RAP1 and RAC1; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; p130Cas linkage to MAPK signaling for integrins; Rap1 signalling; Paradoxical activation of RAF signaling by kinase inactive BRAF; Frs2-mediated activation; Neutrophil degranulation; Interleukin-20 family signaling,67,High,1
P61221,ATP-binding cassette sub-family E member 1 OS=Homo sapiens OX=9606 GN=ABCE1 PE=1 SV=1,0,125.351,40,17,187,17,599,67.3,8.34,80712,,17,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;membrane;mitochondrion;organelle lumen,catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding,"Pf00005, Pf04068, Pf13304, Pf13671",6059,ENSG00000164163.10,ABCE1,4,,,Interferon alpha/beta signaling,4,High,1
O75396,Vesicle-trafficking protein SEC22b OS=Homo sapiens OX=9606 GN=SEC22B PE=1 SV=4,0,125.249,53,13,275,13,215,24.6,6.92,134863,0,13,1,cell organization and biogenesis;regulation of biological process;transport,endoplasmic reticulum;Golgi;membrane,protein binding,"Pf00957, Pf13774",9554,,SEC22B,1,SNARE interactions in vesicular transport; Legionellosis; Phagosome,,COPI-dependent Golgi-to-ER retrograde traffic; Cargo concentration in the ER; COPII (Coat Protein 2) Mediated Vesicle Transport; ER-Phagosome pathway,20,High,1
P28288,ATP-binding cassette sub-family D member 3 OS=Homo sapiens OX=9606 GN=ABCD3 PE=1 SV=1,0,125.163,28,16,136,16,659,75.4,9.36,59391,,16,,cell organization and biogenesis;metabolic process;response to stimulus;transport,cytosol;membrane;mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding;transporter activity,"Pf00005, Pf06472",5825,ENSG00000117528.11,ABCD3,1,ABC transporters; Peroxisome,Nuclear Receptors in Lipid Metabolism and Toxicity,ABC transporters in lipid homeostasis,6,High,1
O60488,Long-chain-fatty-acid--CoA ligase 4 OS=Homo sapiens OX=9606 GN=ACSL4 PE=1 SV=2,0,125.157,32,18,132,17,711,79.1,8.38,54683,0,18,1,cell differentiation;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;membrane;mitochondrion,catalytic activity;nucleotide binding,Pf00501,2182,ENSG00000068366.19,ACSL4,X,Fatty acid biosynthesis; Adipocytokine signaling pathway; Fatty acid degradation; Fatty acid metabolism; Metabolic pathways; PPAR signaling pathway; Peroxisome,Fatty Acid Beta Oxidation; Fatty Acid Biosynthesis; Mitochondrial LC-Fatty Acid Beta-Oxidation; PPAR signaling pathway,Synthesis of very long-chain fatty acyl-CoAs,16,High,1
Q7L2E3,ATP-dependent RNA helicase DHX30 OS=Homo sapiens OX=9606 GN=DHX30 PE=1 SV=1,0,125.142,28,25,107,25,1194,133.9,8.78,45062,,25,,cell organization and biogenesis;metabolic process,cytoplasm;cytosol;mitochondrion,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00270, Pf00271, Pf04408, Pf07717",22907,ENSG00000132153.14,DHX30,3,,,,0,High,1
P51116,Fragile X mental retardation syndrome-related protein 2 OS=Homo sapiens OX=9606 GN=FXR2 PE=1 SV=2,0,125.08,38,17,127,13,673,74.2,6.23,54297,2.48,17,2,regulation of biological process,cytoplasm;cytosol;membrane;nucleus,protein binding;RNA binding,"Pf00013, Pf05641, Pf12235, Pf13014",9513,ENSG00000129245.11,FXR2,17,RNA transport,,,1,High,1
P61764,Syntaxin-binding protein 1 OS=Homo sapiens OX=9606 GN=STXBP1 PE=1 SV=1,0,125.065,39,18,144,18,594,67.5,6.96,56297,0,18,2,cell communication;cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus,protein binding;RNA binding,Pf00995,6812,ENSG00000136854.19,STXBP1,9,Synaptic vesicle cycle,Synaptic Vesicle Pathway; EGF/EGFR Signaling Pathway; Insulin Signaling,"Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Regulation of insulin secretion; Norepinephrine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Neurexins and neuroligins; GABA synthesis, release, reuptake and degradation",18,High,1
Q9NQH7,Xaa-Pro aminopeptidase 3 OS=Homo sapiens OX=9606 GN=XPNPEP3 PE=1 SV=1,0,125.065,37,13,141,13,507,57,6.83,67831,3.64,12,2,metabolic process,mitochondrion,catalytic activity;metal ion binding,"Pf00557, Pf05195",63929,ENSG00000196236.12,XPNPEP3,22,,,,0,High,1
P29992,Guanine nucleotide-binding protein subunit alpha-11 OS=Homo sapiens OX=9606 GN=GNA11 PE=1 SV=2,0,124.93,47,13,193,6,359,42.1,5.69,89126,,13,,regulation of biological process;response to stimulus,cytoplasm;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,"Pf00025, Pf00503",2767,ENSG00000088256.8,GNA11,19,Aldosterone synthesis and secretion; cGMP-PKG signaling pathway; Cholinergic synapse; Gap junction; Amoebiasis; Pathways in cancer; Calcium signaling pathway; Vascular smooth muscle contraction; GnRH signaling pathway; Chagas disease (American trypanosomiasis); Long-term depression; Insulin secretion,Corticotropin-releasing hormone signaling pathway; G Protein Signaling Pathways; GPR40 PATHWAY; Calcium Regulation in the Cardiac Cell,Thrombin signalling through proteinase activated receptors (PARs); Acetylcholine regulates insulin secretion; Gastrin-CREB signalling pathway via PKC and MAPK; Thromboxane signalling through TP receptor; ADP signalling through P2Y purinoceptor 1; Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion,33,High,1
Q9BTE6-3,Isoform 3 of Alanyl-tRNA editing protein Aarsd1 OS=Homo sapiens OX=9606 GN=AARSD1,0,124.92,45,19,99,19,586,65.7,6.51,37707,22.46,15,5,metabolic process;regulation of biological process,cytoplasm;nucleus,catalytic activity;metal ion binding;nucleotide binding,"Pf01411, Pf04969, Pf07973",100885850; 100885848; 80755,ENSG00000108825.17,PTGES3L-AARSD1; PTGES3L; AARSD1,17,,,,0,High,1
P62140,Serine/threonine-protein phosphatase PP1-beta catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CB PE=1 SV=3,0,124.866,40,14,279,7,327,37.2,6.19,137508,7.72,12,3,cell division;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;protein binding,Pf00149,5500,ENSG00000213639.9,PPP1CB,2,Focal adhesion; Oxytocin signaling pathway; cAMP signaling pathway; Herpes simplex infection; Amphetamine addiction; Regulation of actin cytoskeleton; Dopaminergic synapse; Adrenergic signaling in cardiomyocytes; Insulin resistance; Hippo signaling pathway; Inflammatory mediator regulation of TRP channels; mRNA surveillance pathway; Insulin signaling pathway; Platelet activation; Alcoholism; Oocyte meiosis; Proteoglycans in cancer; Long-term potentiation; cGMP-PKG signaling pathway; Vascular smooth muscle contraction,Common Pathways Underlying Drug Addiction; G13 Signaling Pathway,Triglyceride catabolism; RHO GTPases activate PAKs; RHO GTPases Activate ROCKs; Regulation of PLK1 Activity at G2/M Transition; Downregulation of TGF-beta receptor signaling; RHO GTPases activate CIT; RHO GTPases activate PKNs; Circadian Clock,43,High,1
Q86UE4,Protein LYRIC OS=Homo sapiens OX=9606 GN=MTDH PE=1 SV=2,0,124.857,35,17,96,17,582,63.8,9.32,47644,1.9,17,2,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;endoplasmic reticulum;membrane;nucleus,protein binding;RNA binding,,92140,ENSG00000147649.9,MTDH,8,,Gastric cancer network 2,,1,High,1
Q92667,"A-kinase anchor protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=AKAP1 PE=1 SV=1",0,124.76,31,19,101,19,903,97.3,4.94,40916,12.1,18,2,coagulation;regulation of biological process,cytosol;membrane;mitochondrion,protein binding;RNA binding,"Pf00013, Pf00567, Pf12072, Pf13014",8165,ENSG00000121057.12,AKAP1,17,,G Protein Signaling Pathways,Mitochondrial calcium ion transport; Factors involved in megakaryocyte development and platelet production,5,High,1
O60256,Phosphoribosyl pyrophosphate synthase-associated protein 2 OS=Homo sapiens OX=9606 GN=PRPSAP2 PE=1 SV=1,0,124.693,51,14,186,13,369,40.9,7.44,76252,5.05,14,3,metabolic process;regulation of biological process,,catalytic activity;enzyme regulator activity;metal ion binding;protein binding,"Pf13793, Pf14572",5636,ENSG00000141127.14,PRPSAP2,17,,,,0,High,1
P18428,Lipopolysaccharide-binding protein OS=Homo sapiens OX=9606 GN=LBP PE=1 SV=3,0,124.518,28,14,390,14,481,53.4,6.7,181950,4.34,14,3,cellular component movement;defense response;regulation of biological process;response to stimulus;transport,cell surface;extracellular;membrane,protein binding,"Pf01273, Pf02886",3929,ENSG00000129988.5,LBP,20,Toll-like receptor signaling pathway; Tuberculosis; Salmonella infection; NF-kappa B signaling pathway,Regulation of toll-like receptor signaling pathway; Toll-like receptor signaling pathway,Transfer of LPS from LBP carrier to CD14; Interleukin-4 and 13 signaling; Regulation of TLR by endogenous ligand,15,High,1
Q9H9B4,Sideroflexin-1 OS=Homo sapiens OX=9606 GN=SFXN1 PE=1 SV=4,0,124.434,56,14,377,12,322,35.6,9.07,168034,0,13,1,cell differentiation;transport,membrane;mitochondrion,transporter activity,Pf03820,94081,ENSG00000164466.12,SFXN1,5,,,,0,High,1
Q7Z3J2,VPS35 endosomal protein sorting factor-like OS=Homo sapiens OX=9606 GN=VPS35L PE=1 SV=2,0,124.424,25,19,130,19,963,109.5,7.21,58069,5.76,19,1,transport,endosome;membrane,protein binding,,57020,ENSG00000103544.14,C16orf62,16,,,Neutrophil degranulation,3,High,1
P49720,Proteasome subunit beta type-3 OS=Homo sapiens OX=9606 GN=PSMB3 PE=1 SV=2,0,124.287,56,13,278,13,205,22.9,6.55,130367,13.62,13,1,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus;proteasome,catalytic activity;enzyme regulator activity;protein binding,Pf00227,5691,ENSG00000275903.2; ENSG00000277791.4,PSMB3,17; CHR_HSCHR17_7_CTG4,Proteasome,Proteasome Degradation,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,150,High,1
Q9P015,"39S ribosomal protein L15, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL15 PE=1 SV=1",0,124.262,55,16,181,16,296,33.4,10.01,82855,2.04,16,2,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,protein binding;RNA binding;structural molecule activity,Pf00828,29088,ENSG00000137547.8,MRPL15,8,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
P31323,cAMP-dependent protein kinase type II-beta regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR2B PE=1 SV=3,0,124.219,38,13,236,10,418,46.3,4.92,114300,,13,,coagulation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding,"Pf00027, Pf02197",5577,ENSG00000005249.12; ENSG00000284096.1,PRKAR2B,7; CHR_HG2266_PATCH,Insulin signaling pathway,miRs in Muscle Cell Differentiation; Myometrial Relaxation and Contraction Pathways; G Protein Signaling Pathways; Calcium Regulation in the Cardiac Cell; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,DARPP-32 events; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Hedgehog 'off' state; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; Vasopressin regulates renal water homeostasis via Aquaporins; Factors involved in megakaryocyte development and platelet production; Signaling by GPCR; PKA activation in glucagon signalling; PKA activation,48,High,1
P49721,Proteasome subunit beta type-2 OS=Homo sapiens OX=9606 GN=PSMB2 PE=1 SV=1,0,124.082,67,14,223,14,201,22.8,7.02,105909,0,14,1,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus;proteasome,catalytic activity;enzyme regulator activity;protein binding,Pf00227,5690,ENSG00000126067.11,PSMB2,1,Proteasome,Proteasome Degradation,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,150,High,1
Q9UGJ0,5'-AMP-activated protein kinase subunit gamma-2 OS=Homo sapiens OX=9606 GN=PRKAG2 PE=1 SV=1,0,123.94,35,16,191,15,569,63,9.35,86942,7.09,15,1,cell communication;metabolic process;regulation of biological process;response to stimulus;transport,cytosol,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding,"Pf00478, Pf00571",51422,ENSG00000106617.13,PRKAG2,7,Oxytocin signaling pathway; Longevity regulating pathway - multiple species; Hypertrophic cardiomyopathy (HCM); Insulin resistance; AMPK signaling pathway; FoxO signaling pathway; Longevity regulating pathway; Circadian rhythm; Glucagon signaling pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Non-alcoholic fatty liver disease (NAFLD),AMP-activated Protein Kinase (AMPK) Signaling; Target Of Rapamycin (TOR) Signaling; Energy Metabolism; Sterol Regulatory Element-Binding Proteins (SREBP) signalling; Ectoderm Differentiation; Angiopoietin Like Protein 8 Regulatory Pathway,Translocation of GLUT4 to the plasma membrane; Energy dependent regulation of mTOR by LKB1-AMPK; Import of palmitoyl-CoA into the mitochondrial matrix; TP53 Regulates Metabolic Genes; Regulation of TP53 Activity through Phosphorylation; Macroautophagy; AMPK inhibits chREBP transcriptional activation activity; Activation of PPARGC1A (PGC-1alpha) by phosphorylation,42,High,1
P02794,Ferritin heavy chain OS=Homo sapiens OX=9606 GN=FTH1 PE=1 SV=2,0,123.908,44,12,765,12,183,21.2,5.55,388116,3.43,12,3,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;extracellular;nucleus;vacuole,catalytic activity;metal ion binding;protein binding,Pf00210,2495,ENSG00000167996.15,FTH1,11,Mineral absorption,Iron metabolism in placenta; NRF2 pathway,Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Iron uptake and transport; Scavenging by Class A Receptors,15,High,1
P46777,60S ribosomal protein L5 OS=Homo sapiens OX=9606 GN=RPL5 PE=1 SV=3,0,123.9,26,12,267,12,297,34.3,9.72,120473,0,12,1,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;membrane;nucleus;ribosome,protein binding;RNA binding;structural molecule activity,"Pf00861, Pf14204",6125,ENSG00000122406.12,RPL5,1,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
P57772,Selenocysteine-specific elongation factor OS=Homo sapiens OX=9606 GN=EEFSEC PE=1 SV=4,0,123.792,33,16,176,16,596,65.3,8.35,78654,2.34,16,1,metabolic process;regulation of biological process,cytoplasm;mitochondrion;nucleus,catalytic activity;nucleotide binding;RNA binding,"Pf00009, Pf03144",60678,ENSG00000132394.10,EEFSEC,3,,Selenium Metabolism and Selenoproteins,Selenocysteine synthesis,5,High,1
Q96F07-2,Isoform 2 of Cytoplasmic FMR1-interacting protein 2 OS=Homo sapiens OX=9606 GN=CYFIP2,0,123.546,19,20,143,6,1253,145.6,7.05,62038,1.77,20,1,cell death;cell growth;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,protein binding,"Pf05994, Pf07159",26999,ENSG00000055163.19,CYFIP2,5,,Regulation of Actin Cytoskeleton,,1,High,1
Q9UMR2,ATP-dependent RNA helicase DDX19B OS=Homo sapiens OX=9606 GN=DDX19B PE=1 SV=1,0,123.53,46,17,136,2,479,53.9,6.3,55797,8.74,17,1,metabolic process;regulation of biological process;transport,cytoplasm;membrane;nucleus;spliceosomal complex,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00270, Pf00271",11269,ENSG00000157349.16,DDX19B,16,,,,0,High,1
P41219,Peripherin OS=Homo sapiens OX=9606 GN=PRPH PE=1 SV=2,0,123.448,39,18,321,13,470,53.6,5.47,153360,1.74,18,2,,membrane,protein binding;structural molecule activity,"Pf00038, Pf04732",5630,ENSG00000135406.13,PRPH,12,Amyotrophic lateral sclerosis (ALS),Amyotrophic lateral sclerosis (ALS),,2,High,1
P80303,Nucleobindin-2 OS=Homo sapiens OX=9606 GN=NUCB2 PE=1 SV=3,0,123.421,45,15,143,15,420,50.2,5.12,63225,0,15,1,,cytoplasm;cytosol;endoplasmic reticulum;Golgi;membrane;nucleus,DNA binding;metal ion binding;protein binding,Pf13499,4925,ENSG00000070081.15,NUCB2,11,,,,0,High,1
O94925-3,"Isoform 3 of Glutaminase kidney isoform, mitochondrial OS=Homo sapiens OX=9606 GN=GLS",0,123.375,35,15,169,2,598,65.4,7.88,75072,9.62,13,2,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;mitochondrion;organelle lumen,catalytic activity;protein binding,Pf04960,2744,ENSG00000115419.12,GLS,2,,Amino Acid metabolism,,1,High,1
Q9UQ16,Dynamin-3 OS=Homo sapiens OX=9606 GN=DNM3 PE=1 SV=4,0,123.284,17,17,261,3,869,97.7,8.35,128895,,17,,cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytoskeleton;Golgi;membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding,"Pf00169, Pf00350, Pf01031, Pf02212",26052,ENSG00000197959.13,DNM3,1,Synaptic vesicle cycle; Endocytosis; Phospholipase D signaling pathway; Endocrine and other factor-regulated calcium reabsorption; Bacterial invasion of epithelial cells,Synaptic Vesicle Pathway,Retrograde neurotrophin signalling; Toll Like Receptor 4 (TLR4) Cascade; Clathrin-mediated endocytosis; MHC class II antigen presentation; Recycling pathway of L1,24,High,1
Q06210,Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 OS=Homo sapiens OX=9606 GN=GFPT1 PE=1 SV=3,0,123.063,36,20,117,16,699,78.8,7.11,50808,,20,,metabolic process;regulation of biological process,cytosol,catalytic activity,"Pf00310, Pf01380, Pf13230, Pf13522, Pf13537, Pf13580",2673,ENSG00000198380.12,GFPT1,2,"Metabolic pathways; Alanine, aspartate and glutamate metabolism; Insulin resistance; Amino sugar and nucleotide sugar metabolism",,XBP1(S) activates chaperone genes; Defective GFPT1 causes CMSTA1; Synthesis of UDP-N-acetyl-glucosamine,17,High,1
P48449,Lanosterol synthase OS=Homo sapiens OX=9606 GN=LSS PE=1 SV=1,0,123.059,32,19,151,19,732,83.3,6.61,66299,,19,,metabolic process;regulation of biological process,endoplasmic reticulum;membrane,catalytic activity,"Pf00432, Pf09492, Pf13243, Pf13249",4047,ENSG00000160285.14,LSS,21,Metabolic pathways; Steroid biosynthesis,Cholesterol Biosynthesis; Sterol Regulatory Element-Binding Proteins (SREBP) signalling,Cholesterol biosynthesis; Activation of gene expression by SREBF (SREBP),10,High,1
Q8N8N7,Prostaglandin reductase 2 OS=Homo sapiens OX=9606 GN=PTGR2 PE=1 SV=1,0,123.048,48,14,406,14,351,38.5,5.41,200815,0,14,1,metabolic process,cytoplasm,catalytic activity;metal ion binding,Pf00107,145482,ENSG00000140043.11,PTGR2,14,,,Synthesis of Prostaglandins (PG) and Thromboxanes (TX),5,High,1
O95155,Ubiquitin conjugation factor E4 B OS=Homo sapiens OX=9606 GN=UBE4B PE=1 SV=1,0,122.946,24,20,122,20,1302,146.1,6.55,52604,11.42,19,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf04564, Pf10408",10277,ENSG00000130939.18,UBE4B,1,Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum,,,2,High,1
O94875-6,Isoform 6 of Sorbin and SH3 domain-containing protein 2 OS=Homo sapiens OX=9606 GN=SORBS2,0,122.939,58,8,565,0,156,18,9.6,266403,48.84,7,3,cell growth;cell organization and biogenesis,cytoskeleton;membrane;nucleus,protein binding;RNA binding;structural molecule activity,Pf02208,8470,,SORBS2,4,,,,0,Not Found,1
Q9NVD7,Alpha-parvin OS=Homo sapiens OX=9606 GN=PARVA PE=1 SV=1,0,122.928,37,14,377,11,372,42.2,5.95,184832,0,14,1,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane,protein binding,Pf00307,55742,,PARVA,11,Focal adhesion,Primary Focal Segmental Glomerulosclerosis FSGS,Localization of the PINCH-ILK-PARVIN complex to focal adhesions; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components,7,High,1
Q8NBU5,ATPase family AAA domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ATAD1 PE=1 SV=1,0,122.911,42,13,344,13,361,40.7,6.9,175075,0,13,2,metabolic process;regulation of biological process;response to stimulus,membrane;mitochondrion;nucleus,catalytic activity;nucleotide binding;RNA binding,"Pf00004, Pf00910, Pf01078, Pf05496, Pf06068, Pf07724, Pf07726, Pf13173, Pf13191, Pf13207, Pf13479",84896,ENSG00000283024.1; ENSG00000138138.13,ATAD1,10; CHR_HG2334_PATCH,,,,0,High,1
Q16082,Heat shock protein beta-2 OS=Homo sapiens OX=9606 GN=HSPB2 PE=1 SV=2,0,122.835,54,8,271,8,182,20.2,5.17,143418,,8,,regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,enzyme regulator activity;protein binding,Pf00011,3316; 100528019,ENSG00000170276.5; ENSG00000254445.1,HSPB2; HSPB2-C11orf52,11,Epstein-Barr virus infection; Proteoglycans in cancer,IL-1 signaling pathway; MAPK Signaling Pathway,,4,High,1
Q9Y2R9,"28S ribosomal protein S7, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS7 PE=1 SV=2",0,122.716,46,13,236,12,242,28.1,9.99,101804,1.73,13,3,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,RNA binding;structural molecule activity,Pf00177,51081,ENSG00000125445.10,MRPS7,17,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
Q99685,Monoglyceride lipase OS=Homo sapiens OX=9606 GN=MGLL PE=1 SV=2,0,122.681,52,12,208,12,303,33.2,6.99,90708,0,12,1,defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;protein binding,"Pf00561, Pf00756, Pf00975, Pf01764, Pf12146, Pf12695, Pf12697",11343,ENSG00000074416.13,MGLL,3,Metabolic pathways; Glycerolipid metabolism; Regulation of lipolysis in adipocytes; Retrograde endocannabinoid signaling,,Triglyceride catabolism; Arachidonate production from DAG; Gastrin-CREB signalling pathway via PKC and MAPK; Acyl chain remodeling of DAG and TAG,20,High,1
Q96AB3,Isochorismatase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ISOC2 PE=1 SV=1,0,122.639,48,6,220,6,205,22.3,7.77,115047,,6,,metabolic process;regulation of biological process,cytoplasm;nucleus,catalytic activity;protein binding,Pf00857,79763,ENSG00000063241.7,ISOC2,19,,,,0,High,1
P42356,Phosphatidylinositol 4-kinase alpha OS=Homo sapiens OX=9606 GN=PI4KA PE=1 SV=4,0,122.571,16,26,105,26,2102,236.7,7.06,36751,,26,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00454, Pf00613",5297,ENSG00000241973.10,PI4KA,22,Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system,Ectoderm Differentiation,Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the ER membrane,10,High,1
Q96PE2,Rho guanine nucleotide exchange factor 17 OS=Homo sapiens OX=9606 GN=ARHGEF17 PE=1 SV=1,0,122.531,14,18,70,18,2063,221.5,6.29,30997,,18,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytosol,protein binding,Pf00621,9828,ENSG00000110237.3,ARHGEF17,11,,,G alpha (12/13) signalling events; NRAGE signals death through JNK; Signalling by NGF; Rho GTPase cycle,11,High,1
O75915,PRA1 family protein 3 OS=Homo sapiens OX=9606 GN=ARL6IP5 PE=1 SV=1,0,122.45,35,10,487,10,188,21.6,9.77,246339,0,10,1,regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;endoplasmic reticulum;membrane,protein binding,"Pf02990, Pf03208",10550,ENSG00000144746.6,ARL6IP5,3,,,Glutamate Neurotransmitter Release Cycle,4,High,1
P04899,Guanine nucleotide-binding protein G(i) subunit alpha-2 OS=Homo sapiens OX=9606 GN=GNAI2 PE=1 SV=3,0,122.415,43,13,359,7,355,40.4,5.54,170120,7.05,12,1,cell division;cell proliferation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,"Pf00025, Pf00503",2771,ENSG00000114353.16,GNAI2,3,Progesterone-mediated oocyte maturation; Gastric acid secretion; Glutamatergic synapse; Retrograde endocannabinoid signaling; Pertussis; Regulation of lipolysis in adipocytes; Morphine addiction; Chemokine signaling pathway; Renin secretion; Cocaine addiction; Serotonergic synapse; Parkinson's disease; Gap junction; cAMP signaling pathway; Oxytocin signaling pathway; GABAergic synapse; Dopaminergic synapse; Toxoplasmosis; Cholinergic synapse; Rap1 signaling pathway; Sphingolipid signaling pathway; Adrenergic signaling in cardiomyocytes; Estrogen signaling pathway; cGMP-PKG signaling pathway; Leukocyte transendothelial migration; Pathways in cancer; Axon guidance; Tight junction; Long-term depression; Circadian entrainment; Alcoholism; Chagas disease (American trypanosomiasis); Melanogenesis; Platelet activation,Human Thyroid Stimulating Hormone (TSH) signaling pathway; Corticotropin-releasing hormone signaling pathway; Signal Transduction of S1P Receptor; G Protein Signaling Pathways; Chemokine signaling pathway; Calcium Regulation in the Cardiac Cell,"G alpha (z) signalling events; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G alpha (s) signalling events; PLC beta mediated events; ADP signalling through P2Y purinoceptor 12; Adrenaline,noradrenaline inhibits insulin secretion; Adenylate cyclase inhibitory pathway; G-protein activation",70,High,1
Q8N1F7,Nuclear pore complex protein Nup93 OS=Homo sapiens OX=9606 GN=NUP93 PE=1 SV=2,0,122.334,32,24,109,24,819,93.4,5.72,45540,1.76,23,1,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,membrane;nucleus,protein binding;structural molecule activity,Pf04097,9688,ENSG00000102900.12,NUP93,16,RNA transport,,Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins,64,High,1
Q9BZE1,"39S ribosomal protein L37, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL37 PE=1 SV=2",0,122.161,47,20,198,20,423,48.1,8.59,91166,,20,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,RNA binding;structural molecule activity,Pf07147,51253,ENSG00000116221.15,MRPL37,1,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
P18085,ADP-ribosylation factor 4 OS=Homo sapiens OX=9606 GN=ARF4 PE=1 SV=3,0,122.13,53,8,393,4,180,20.5,7.14,193406,1.65,8,4,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;Golgi;membrane,catalytic activity;nucleotide binding;protein binding;signal transducer activity,"Pf00025, Pf00071, Pf00503, Pf01926, Pf04670, Pf08477, Pf09439",378,ENSG00000168374.10,ARF4,3,,,COPI-dependent Golgi-to-ER retrograde traffic; VxPx cargo-targeting to cilium; COPI-mediated anterograde transport,15,High,1
O43301,Heat shock 70 kDa protein 12A OS=Homo sapiens OX=9606 GN=HSPA12A PE=1 SV=2,0,122.085,31,18,144,15,675,74.9,6.77,64991,0,18,1,,,nucleotide binding,Pf00012,259217,ENSG00000165868.13,HSPA12A,10,,,Regulation of HSF1-mediated heat shock response,4,High,1
Q86UU1,Pleckstrin homology-like domain family B member 1 OS=Homo sapiens OX=9606 GN=PHLDB1 PE=1 SV=1,0,122.023,21,22,91,21,1377,151.1,8.63,37829,0,22,1,metabolic process;regulation of biological process,,protein binding,"Pf00169, Pf00498, Pf03962, Pf04012, Pf04111, Pf10473, Pf12128, Pf14593, Pf15409",23187,ENSG00000019144.18,PHLDB1,11,,,,0,High,1
P53992,Protein transport protein Sec24C OS=Homo sapiens OX=9606 GN=SEC24C PE=1 SV=3,0,121.947,21,18,176,18,1094,118.2,7.06,84573,0,18,1,cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytosol;endoplasmic reticulum;membrane,metal ion binding;protein binding,"Pf00626, Pf03154, Pf04503, Pf04652, Pf04810, Pf04811, Pf04815, Pf07223, Pf08033, Pf09606, Pf09770, Pf15449",9632,ENSG00000176986.15,SEC24C,10,Protein processing in endoplasmic reticulum,Sterol Regulatory Element-Binding Proteins (SREBP) signalling,"Regulation of cholesterol biosynthesis by SREBP (SREBF); Cargo concentration in the ER; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; COPII (Coat Protein 2) Mediated Vesicle Transport; MHC class II antigen presentation",20,High,1
Q9BXJ9,"N-alpha-acetyltransferase 15, NatA auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA15 PE=1 SV=1",0,121.857,30,23,188,23,866,101.2,7.42,80626,,23,,cell differentiation;development;metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;nucleus,catalytic activity;protein binding;RNA binding,"Pf12569, Pf13414",80155,ENSG00000164134.12,NAA15,4,,,,0,High,1
Q8N0X4,"Citramalyl-CoA lyase, mitochondrial OS=Homo sapiens OX=9606 GN=CLYBL PE=1 SV=2",0,121.689,49,12,204,12,340,37.3,8.73,103762,4.01,12,1,,mitochondrion,catalytic activity;metal ion binding,"Pf03328, Pf15617",171425,ENSG00000125246.15,CLYBL,13,,,,0,High,1
Q9HBI1,Beta-parvin OS=Homo sapiens OX=9606 GN=PARVB PE=1 SV=1,0,121.674,45,13,225,10,364,41.7,6.73,113395,0,13,1,cell organization and biogenesis;regulation of biological process,cytoplasm;cytoskeleton;cytosol;membrane,protein binding,Pf00307,29780,ENSG00000188677.14,PARVB,22,Focal adhesion,Focal Adhesion,Regulation of cytoskeletal remodeling and cell spreading by IPP complex components,6,High,1
P62277,40S ribosomal protein S13 OS=Homo sapiens OX=9606 GN=RPS13 PE=1 SV=2,0,121.652,45,13,411,13,151,17.2,10.54,190079,7.52,13,1,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytosol;membrane;nucleus;ribosome,protein binding;RNA binding;structural molecule activity,"Pf00312, Pf08069",6207,ENSG00000110700.6,RPS13,11,Ribosome,Cytoplasmic Ribosomal Proteins,"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane",38,High,1
Q9H1H9,Kinesin-like protein KIF13A OS=Homo sapiens OX=9606 GN=KIF13A PE=1 SV=2,0,121.579,18,25,87,20,1805,202.2,5.6,37163,,25,,cell division;cell organization and biogenesis;cellular component movement;transport,cytoplasm;cytoskeleton;endosome;Golgi;membrane,catalytic activity;motor activity;nucleotide binding;protein binding,"Pf00225, Pf00498, Pf12423, Pf12473",63971,ENSG00000137177.19,KIF13A,6,,,Association of TriC/CCT with target proteins during biosynthesis,4,High,1
Q13976,cGMP-dependent protein kinase 1 OS=Homo sapiens OX=9606 GN=PRKG1 PE=1 SV=3,0,121.579,33,20,143,20,671,76.3,6.04,64750,2.62,20,2,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;Golgi;membrane,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding,"Pf00027, Pf00069, Pf07714, Pf14531",5592,ENSG00000185532.15,PRKG1,10,Regulation of lipolysis in adipocytes; Circadian entrainment; Long-term depression; cGMP-PKG signaling pathway; Platelet activation; Salivary secretion; Gap junction; Olfactory transduction; Vascular smooth muscle contraction,MicroRNAs in cardiomyocyte hypertrophy; Cardiac Hypertrophic Response; VEGFA-VEGFR2 Signaling Pathway,Rap1 signalling; Ca2+ pathway; cGMP effects,23,High,1
P02748,Complement component C9 OS=Homo sapiens OX=9606 GN=C9 PE=1 SV=2,0,121.456,24,15,301,15,559,63.1,5.59,150036,0,15,3,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,cytosol;extracellular;membrane,protein binding,"Pf00057, Pf00090, Pf01823",735,ENSG00000113600.10,C9,5,Systemic lupus erythematosus; Prion diseases; Complement and coagulation cascades; Amoebiasis,Allograft Rejection; Complement Activation; Complement and Coagulation Cascades,Terminal pathway of complement; Regulation of Complement cascade,12,High,1
P60660,Myosin light polypeptide 6 OS=Homo sapiens OX=9606 GN=MYL6 PE=1 SV=2,0,121.415,60,11,605,8,151,16.9,4.65,296935,27.65,9,2,cellular component movement,cytosol;membrane,catalytic activity;metal ion binding;motor activity;protein binding;structural molecule activity,"Pf00036, Pf13405, Pf13499",4637,ENSG00000092841.18,MYL6,12,Oxytocin signaling pathway; Vascular smooth muscle contraction,Focal Adhesion,RHO GTPases activate PAKs; EPHA-mediated growth cone collapse; RHO GTPases Activate ROCKs; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate CIT; RHO GTPases activate PKNs,19,High,1
P27361,Mitogen-activated protein kinase 3 OS=Homo sapiens OX=9606 GN=MAPK3 PE=1 SV=4,0,121.289,40,14,184,11,379,43.1,6.74,84443,0,14,2,cell communication;cell death;cell differentiation;cell organization and biogenesis;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endosome;Golgi;membrane;mitochondrion;nucleus,catalytic activity;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf01636, Pf07714",5595,ENSG00000102882.11,MAPK3,16,T cell receptor signaling pathway; Central carbon metabolism in cancer; Leishmaniasis; Type II diabetes mellitus; Renal cell carcinoma; Choline metabolism in cancer; Toll-like receptor signaling pathway; Axon guidance; Serotonergic synapse; Hepatitis B; Neurotrophin signaling pathway; Endometrial cancer; Gap junction; Melanogenesis; Retrograde endocannabinoid signaling; Endocrine resistance; Platelet activation; Prion diseases; Phospholipase D signaling pathway; MAPK signaling pathway; Long-term potentiation; EGFR tyrosine kinase inhibitor resistance; Adherens junction; Alcoholism; Estrogen signaling pathway; TNF signaling pathway; Pancreatic cancer; Rap1 signaling pathway; ErbB signaling pathway; Tuberculosis; mTOR signaling pathway; Fc epsilon RI signaling pathway; Signaling pathways regulating pluripotency of stem cells; TGF-beta signaling pathway; Insulin signaling pathway; VEGF signaling pathway; Colorectal cancer; Adrenergic signaling in cardiomyocytes; Proteoglycans in cancer; Sphingolipid signaling pathway; GnRH signaling pathway; Platinum drug resistance; Chagas disease (American trypanosomiasis); Vascular smooth muscle contraction; Chronic myeloid leukemia; Circadian entrainment; Thyroid hormone signaling pathway; Apoptosis; Regulation of actin cytoskeleton; Ras signaling pathway; PI3K-Akt signaling pathway; NOD-like receptor signaling pathway; Prolactin signaling pathway; Progesterone-mediated oocyte maturation; Pathways in cancer; Melanoma; Salmonella infection; Thyroid cancer; Influenza A; Acute myeloid leukemia; Alzheimer's disease; B cell receptor signaling pathway; Focal adhesion; Shigellosis; cGMP-PKG signaling pathway; Toxoplasmosis; Cholinergic synapse; FoxO signaling pathway; Pertussis; cAMP signaling pathway; HIF-1 signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Chemokine signaling pathway; Glutamatergic synapse; Glioma; Fc gamma R-mediated phagocytosis; Osteoclast differentiation; Prostate cancer; Hepatitis C; Dorso-ventral axis formation; Natural killer cell mediated cytotoxicity; Bladder cancer; Th1 and Th2 cell differentiation; Breast cancer; Oocyte meiosis; Viral carcinogenesis; Oxytocin signaling pathway; Long-term depression; Non-small cell lung cancer; Aldosterone-regulated sodium reabsorption,"IL-5 Signaling Pathway; Osteopontin Signaling; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; Human Thyroid Stimulating Hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle Stimulating Hormone (FSH) signaling pathway; TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway; Prolactin Signaling Pathway; IL-7 Signaling Pathway; Alzheimers Disease; IL17 signaling pathway; IL-9 Signaling Pathway; Signaling Pathways in Glioblastoma; TNF alpha Signaling Pathway; AGE/RAGE pathway; Interleukin-11 Signaling Pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Spinal Cord Injury; Alpha 6 Beta 4 signaling pathway; PDGF Pathway; Signal Transduction of S1P Receptor; Common Pathways Underlying Drug Addiction; Structural Pathway of Interleukin 1 (IL-1); Cardiac Hypertrophic Response; IL-3 Signaling Pathway; TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer; Kit receptor signaling pathway; Signaling of Hepatocyte Growth Factor Receptor; Rac1/Pak1/p38/MMP-2 pathway; IL-6 signaling pathway; Hepatitis C and Hepatocellular Carcinoma; Hypothesized Pathways in Pathogenesis of Cardiovascular Disease; MAPK Signaling Pathway; T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; BMP Signaling Pathway in Eyelid Development; Chemokine signaling pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; IL-4 Signaling Pathway; MAPK Cascade; Insulin Signaling; IL-2 Signaling Pathway; Regulation of Actin Cytoskeleton; TGF-beta Receptor Signaling; EPO Receptor Signaling; T-Cell antigen Receptor (TCR)  Signaling Pathway; Serotonin Receptor 2 and ELK-SRF/GATA4 signaling; Serotonin Receptor 4/6/7 and NR3C Signaling; Toll-like receptor signaling pathway","ISG15 antiviral mechanism; NCAM signaling for neurite out-growth; Activated TLR4 signalling; Negative feedback regulation of MAPK pathway; RUNX2 regulates osteoblast differentiation; Regulation of actin dynamics for phagocytic cup formation; Signaling by BRAF and RAF fusions; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; ERKs are inactivated; MAP2K and MAPK activation; FCERI mediated MAPK activation; Signaling by GPCR; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signal attenuation; Activation of the AP-1 family of transcription factors; Interleukin-20 family signaling; Spry regulation of FGF signaling; Signal transduction by L1; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Regulation of HSF1-mediated heat shock response; MAPK3 (ERK1) activation; Advanced glycosylation endproduct receptor signaling; Thrombin signalling through proteinase activated receptors (PARs); Gastrin-CREB signalling pathway via PKC and MAPK; Regulation of PTEN gene transcription; RHO GTPases Activate WASPs and WAVEs; Oncogene Induced Senescence; Growth hormone receptor signaling; Senescence-Associated Secretory Phenotype (SASP); Oxidative Stress Induced Senescence; RNA Polymerase I Promoter Opening",253,High,1
P82673,"28S ribosomal protein S35, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS35 PE=1 SV=1",0,121.267,48,14,192,14,323,36.8,8.24,90055,7.86,14,2,cell organization and biogenesis;metabolic process;response to stimulus,membrane;mitochondrion;ribosome,RNA binding;structural molecule activity,Pf10213,60488,ENSG00000061794.12,MRPS35,12,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
O43399-7,Isoform 7 of Tumor protein D54 OS=Homo sapiens OX=9606 GN=TPD52L2,0,121.257,64,12,198,2,229,24.8,6.42,98797,2.12,12,1,,,RNA binding,Pf04201,7165,ENSG00000101150.17,TPD52L2,20,,,,0,High,1
Q9UL25,Ras-related protein Rab-21 OS=Homo sapiens OX=9606 GN=RAB21 PE=1 SV=3,0,121.246,43,9,316,8,225,24.3,7.94,150627,1.61,9,2,cellular component movement;regulation of biological process;response to stimulus;transport,cytosol;endoplasmic reticulum;endosome;Golgi;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf08477",23011,ENSG00000080371.5,RAB21,12,,,RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation,7,High,1
P21281,"V-type proton ATPase subunit B, brain isoform OS=Homo sapiens OX=9606 GN=ATP6V1B2 PE=1 SV=3",0,121.095,40,14,197,14,511,56.5,5.81,85475,,14,,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane,catalytic activity;nucleotide binding;protein binding;transporter activity,"Pf00006, Pf00306, Pf02874",526,ENSG00000147416.10,ATP6V1B2,8,Synaptic vesicle cycle; Metabolic pathways; mTOR signaling pathway; Collecting duct acid secretion; Vibrio cholerae infection; Phagosome; Rheumatoid arthritis; Epithelial cell signaling in Helicobacter pylori infection; Oxidative phosphorylation,,"Transferrin endocytosis and recycling; ROS, RNS production in phagocytes; Ion channel transport; Insulin receptor recycling",20,High,1
Q16576,Histone-binding protein RBBP7 OS=Homo sapiens OX=9606 GN=RBBP7 PE=1 SV=1,0,120.872,45,13,179,8,425,47.8,5.05,78840,2.69,12,3,cell organization and biogenesis;cell proliferation;development;metabolic process;regulation of biological process;response to stimulus,cytosol;nucleus,catalytic activity;protein binding;RNA binding,"Pf00400, Pf12265",5931,ENSG00000102054.17,RBBP7,X,,Retinoblastoma (RB) in Cancer; Interactome of polycomb repressive complex 2 (PRC2),RMTs methylate histone arginines; Regulation of TP53 Activity through Acetylation; PKMTs methylate histone lysines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; HATs acetylate histones; Neddylation; Deposition of new CENPA-containing nucleosomes at the centromere; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; PRC2 methylates histones and DNA; HDACs deacetylate histones; Oxidative Stress Induced Senescence; RNA Polymerase I Transcription Initiation,41,High,1
Q1KMD3,Heterogeneous nuclear ribonucleoprotein U-like protein 2 OS=Homo sapiens OX=9606 GN=HNRNPUL2 PE=1 SV=1,0,120.857,27,19,238,19,747,85.1,4.91,110047,0,19,2,,membrane;nucleus,protein binding;RNA binding,"Pf00622, Pf02037, Pf08433, Pf13671",221092,ENSG00000214753.2,HNRNPUL2,11,,,,0,High,1
Q9UKY7,Protein CDV3 homolog OS=Homo sapiens OX=9606 GN=CDV3 PE=1 SV=1,0,120.693,65,11,96,11,258,27.3,6.4,43153,,11,,cell proliferation,cytoplasm,,Pf15359,55573,ENSG00000091527.15,CDV3,3,,,,0,High,1
Q8TDQ7,Glucosamine-6-phosphate isomerase 2 OS=Homo sapiens OX=9606 GN=GNPDA2 PE=1 SV=1,0,120.687,58,12,155,7,276,31.1,6.95,68540,0,12,1,metabolic process,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,Pf01182,132789,ENSG00000163281.11,GNPDA2,4,Metabolic pathways; Amino sugar and nucleotide sugar metabolism,,Glycolysis,6,High,1
Q7L592,"Protein arginine methyltransferase NDUFAF7, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFAF7 PE=1 SV=1",0,120.681,51,19,230,19,441,49.2,8.34,97904,,19,,cell organization and biogenesis;metabolic process,mitochondrion;organelle lumen,catalytic activity;protein binding,Pf02636,55471,ENSG00000003509.15,NDUFAF7,2,,,Complex I biogenesis,5,High,1
P42566,Epidermal growth factor receptor substrate 15 OS=Homo sapiens OX=9606 GN=EPS15 PE=1 SV=2,0,120.664,32,20,86,20,896,98.6,4.64,39037,,20,,cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endosome;membrane;nucleus,catalytic activity;DNA binding;metal ion binding;motor activity;protein binding,"Pf00769, Pf01576, Pf02609, Pf03131, Pf03938, Pf03962, Pf04111, Pf04156, Pf04849, Pf05557, Pf05701, Pf06160, Pf06818, Pf07321, Pf07926, Pf08317, Pf10186, Pf11559, Pf12325, Pf12763, Pf12795, Pf13863, Pf14282, Pf15035, Pf15619",2060,ENSG00000085832.16,EPS15,1,Endocytosis,VEGFA-VEGFR2 Signaling Pathway; EGF/EGFR Signaling Pathway,Cargo recognition for clathrin-mediated endocytosis; Negative regulation of MET activity; EGFR downregulation; InlB-mediated entry of Listeria monocytogenes into host cell,17,High,1
Q9NPL8,"Complex I assembly factor TIMMDC1, mitochondrial OS=Homo sapiens OX=9606 GN=TIMMDC1 PE=1 SV=2",0,120.609,45,11,186,11,285,32.2,8.5,95702,14.23,11,2,cell organization and biogenesis,membrane;mitochondrion;nucleus,protein binding,Pf02466,51300,ENSG00000113845.9,TIMMDC1,3,,,Complex I biogenesis,5,High,1
Q92747,Actin-related protein 2/3 complex subunit 1A OS=Homo sapiens OX=9606 GN=ARPC1A PE=2 SV=2,0,120.524,48,14,133,13,370,41.5,8.18,57588,11.13,13,3,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol,protein binding,Pf00400,10552,ENSG00000241685.9,ARPC1A,7,Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Regulation of actin cytoskeleton; Endocytosis; Fc gamma R-mediated phagocytosis; Salmonella infection,Pathogenic Escherichia coli infection,EPHB-mediated forward signaling; Clathrin-mediated endocytosis; RHO GTPases Activate WASPs and WAVEs; Regulation of actin dynamics for phagocytic cup formation,23,High,1
O95674,Phosphatidate cytidylyltransferase 2 OS=Homo sapiens OX=9606 GN=CDS2 PE=1 SV=1,0,120.411,19,10,206,10,445,51.4,7.09,103562,,10,,metabolic process,endoplasmic reticulum;membrane;mitochondrion,catalytic activity,Pf01148,8760,ENSG00000101290.13,CDS2,20,Metabolic pathways; Phosphatidylinositol signaling system; Glycerophospholipid metabolism,,Synthesis of PG,8,High,1
Q16666,Gamma-interferon-inducible protein 16 OS=Homo sapiens OX=9606 GN=IFI16 PE=1 SV=3,0,120.39,38,20,100,20,785,88.2,9.28,43500,,20,,cell communication;cell death;cell differentiation;cell proliferation;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,DNA binding;protein binding;RNA binding,"Pf02758, Pf02760",3428,ENSG00000163565.18,IFI16,1,NOD-like receptor signaling pathway,Senescence and Autophagy in Cancer,IRF3-mediated induction of type I IFN,7,High,1
Q96E52,"Metalloendopeptidase OMA1, mitochondrial OS=Homo sapiens OX=9606 GN=OMA1 PE=1 SV=1",0,120.382,22,10,277,10,524,60.1,9.25,124132,30.14,9,2,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,membrane;mitochondrion,catalytic activity;metal ion binding,Pf01435,115209,ENSG00000162600.11,OMA1,1,,,Regulation of Apoptosis,3,High,1
P52597,Heterogeneous nuclear ribonucleoprotein F OS=Homo sapiens OX=9606 GN=HNRNPF PE=1 SV=3,0,120.348,36,12,170,10,415,45.6,5.58,87633,0,12,1,metabolic process;regulation of biological process;response to stimulus,cytosol;membrane;nucleus;spliceosomal complex,protein binding;RNA binding,"Pf00076, Pf08080, Pf14259",3185,ENSG00000169813.16,HNRNPF,10,,Mecp2 and Associated Rett Syndrome,Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Interleukin-12 family signaling,15,High,1
Q2M389,WASH complex subunit 4 OS=Homo sapiens OX=9606 GN=WASHC4 PE=1 SV=2,0,120.325,21,19,128,19,1173,136.3,7.44,55079,,19,,cell organization and biogenesis;transport,endosome,,"Pf14744, Pf14745, Pf14746",23325,ENSG00000136051.13,KIAA1033; WASHC4,12,Endocytosis,,,1,High,1
O76041-2,Isoform 2 of Nebulette OS=Homo sapiens OX=9606 GN=NEBL,0,120.278,45,8,640,1,270,31.2,8.31,324692,30.44,6,5,cell organization and biogenesis,,metal ion binding;protein binding;structural molecule activity,"Pf00018, Pf00412, Pf00880, Pf07653, Pf14604",10529,ENSG00000078114.18,NEBL,10,,,,0,High,1
O43681,ATPase ASNA1 OS=Homo sapiens OX=9606 GN=ASNA1 PE=1 SV=2,0,120.149,39,11,261,11,348,38.8,4.91,123712,0,11,1,transport,cytoplasm;endoplasmic reticulum;membrane;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding;transporter activity,Pf02374,439,ENSG00000198356.11,ASNA1,19,,,XBP1(S) activates chaperone genes,4,High,1
Q66LE6,Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform OS=Homo sapiens OX=9606 GN=PPP2R2D PE=1 SV=1,0,120.039,33,13,98,6,453,52,6.39,43515,14.84,12,2,cell division;metabolic process;regulation of biological process,cytoplasm;cytosol,catalytic activity;enzyme regulator activity;protein binding,,55844,ENSG00000175470.18,PPP2R2D,10,mRNA surveillance pathway; Chagas disease (American trypanosomiasis); Hepatitis C; Adrenergic signaling in cardiomyocytes; Tight junction; PI3K-Akt signaling pathway; Dopaminergic synapse; Sphingolipid signaling pathway; AMPK signaling pathway; Hippo signaling pathway,Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,MASTL Facilitates Mitotic Progression,16,High,1
P51452,Dual specificity protein phosphatase 3 OS=Homo sapiens OX=9606 GN=DUSP3 PE=1 SV=1,0,119.895,48,8,388,8,185,20.5,7.8,180122,17.06,8,2,metabolic process;regulation of biological process,cytosol;nucleus,catalytic activity;protein binding,"Pf00102, Pf00782",1845,ENSG00000108861.8,DUSP3,17,MAPK signaling pathway,,ERKs are inactivated; Activated TLR4 signalling,32,High,1
P12081,"Histidine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=HARS PE=1 SV=2",0,119.773,40,19,173,13,509,57.4,5.88,89844,3.07,19,1,cell organization and biogenesis;metabolic process,cytoplasm;cytosol;mitochondrion,catalytic activity;nucleotide binding;protein binding,"Pf00458, Pf00587, Pf03129, Pf13393",3035,ENSG00000170445.12,HARS,5,Aminoacyl-tRNA biosynthesis,Allograft Rejection,Cytosolic tRNA aminoacylation,6,High,1
P49593,Protein phosphatase 1F OS=Homo sapiens OX=9606 GN=PPM1F PE=1 SV=3,0,119.771,43,15,123,15,454,49.8,5.1,57311,2.12,15,2,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytosol,catalytic activity;metal ion binding;protein binding,"Pf00481, Pf13672",9647,ENSG00000100034.13,PPM1F,22,,,,0,High,1
P20020,Plasma membrane calcium-transporting ATPase 1 OS=Homo sapiens OX=9606 GN=ATP2B1 PE=1 SV=4,0,119.695,16,17,183,5,1220,134.6,5.91,89623,,17,,,,,,,,,,,,,0,High,1
Q14161,ARF GTPase-activating protein GIT2 OS=Homo sapiens OX=9606 GN=GIT2 PE=1 SV=2,0,119.584,28,16,121,14,759,84.5,7.23,55938,0,16,1,regulation of biological process,,enzyme regulator activity;metal ion binding;protein binding,"Pf00023, Pf01412, Pf07558, Pf08518, Pf12205, Pf12796, Pf13637, Pf13857",9815,ENSG00000139436.20,GIT2,12,Endocytosis,Integrin-mediated Cell Adhesion,,2,High,1
Q13033-2,Isoform Alpha of Striatin-3 OS=Homo sapiens OX=9606 GN=STRN3,0,119.551,30,16,107,1,713,77.7,5.26,44464,12.92,15,3,regulation of biological process;response to stimulus,Golgi;membrane,protein binding,"Pf00400, Pf08232",29966,ENSG00000196792.11,STRN3,14,,,,0,High,1
P14550,Aldo-keto reductase family 1 member A1 OS=Homo sapiens OX=9606 GN=AKR1A1 PE=1 SV=3,0,119.434,50,15,612,15,325,36.6,6.79,278363,9.76,14,3,metabolic process,cytosol;membrane,catalytic activity;protein binding,Pf00248,10327,ENSG00000117448.13,AKR1A1,1,Glycolysis / Gluconeogenesis; Metabolic pathways; Glycerolipid metabolism; Pentose and glucuronate interconversions,Benzo(a)pyrene metabolism; Metapathway biotransformation,Catabolism of glucuronate to xylulose-5-phosphate; Glutathione conjugation,12,High,1
P07737,Profilin-1 OS=Homo sapiens OX=9606 GN=PFN1 PE=1 SV=2,0,119.312,58,12,1129,12,140,15,8.27,542728,0,12,2,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,enzyme regulator activity;nucleotide binding;protein binding;RNA binding,Pf00235,5216,ENSG00000108518.7,PFN1,17,Rap1 signaling pathway; Shigellosis; Salmonella infection; Regulation of actin cytoskeleton,Association Between Physico-Chemical Features and Toxicity Associated Pathways; VEGFA-VEGFR2 Signaling Pathway; Regulation of Actin Cytoskeleton; G13 Signaling Pathway,Platelet degranulation ; Signaling by ROBO receptors; RHO GTPases Activate Formins; PCP/CE pathway,22,High,1
Q9H8L6,Multimerin-2 OS=Homo sapiens OX=9606 GN=MMRN2 PE=1 SV=2,0,119.241,25,16,95,16,949,104.3,5.86,42348,0,16,3,regulation of biological process;transport,extracellular;membrane,protein binding,"Pf00386, Pf04632, Pf07546, Pf13514",79812,ENSG00000173269.13,MMRN2,10,,VEGFA-VEGFR2 Signaling Pathway,,1,High,1
O60610,Protein diaphanous homolog 1 OS=Homo sapiens OX=9606 GN=DIAPH1 PE=1 SV=2,0,119.111,19,21,99,20,1272,141.3,5.41,42999,,21,,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane,catalytic activity;motor activity;protein binding;RNA binding,"Pf01576, Pf02181, Pf06346, Pf06367, Pf06371, Pf11932",1729,ENSG00000131504.15,DIAPH1,5,Focal adhesion; Shigellosis; Regulation of actin cytoskeleton; AGE-RAGE signaling pathway in diabetic complications,Regulation of Microtubule Cytoskeleton; AGE/RAGE pathway; Focal Adhesion; Regulation of Actin Cytoskeleton; G13 Signaling Pathway,RHO GTPases Activate Formins; ERBB2 Regulates Cell Motility; Neutrophil degranulation,19,High,1
Q96MF6,"Coenzyme Q-binding protein COQ10 homolog A, mitochondrial OS=Homo sapiens OX=9606 GN=COQ10A PE=2 SV=2",0,118.987,49,10,329,9,247,27.7,9.76,116479,206.92,6,7,metabolic process,membrane;mitochondrion,,Pf03364,93058,ENSG00000135469.13,COQ10A,12,,,Respiratory electron transport,4,High,1
P19021,Peptidyl-glycine alpha-amidating monooxygenase OS=Homo sapiens OX=9606 GN=PAM PE=1 SV=2,0,118.742,23,19,150,19,973,108.3,6.42,60230,1.64,19,4,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;extracellular;membrane,catalytic activity;metal ion binding;protein binding,"Pf01082, Pf01436, Pf03712",5066,ENSG00000145730.20,PAM,5,,,,0,High,1
P46782,40S ribosomal protein S5 OS=Homo sapiens OX=9606 GN=RPS5 PE=1 SV=4,0,118.704,28,9,969,9,204,22.9,9.72,363528,0,9,2,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytosol;membrane;ribosome,protein binding;RNA binding;structural molecule activity,Pf00177,6193,ENSG00000083845.8,RPS5,19,Ribosome,Cytoplasmic Ribosomal Proteins,"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane",38,High,1
P39023,60S ribosomal protein L3 OS=Homo sapiens OX=9606 GN=RPL3 PE=1 SV=2,0,118.686,35,12,744,11,403,46.1,10.18,306924,7.5,11,1,cell organization and biogenesis;metabolic process;response to stimulus;transport,cytoplasm;cytosol;nucleus;ribosome,protein binding;RNA binding;structural molecule activity,Pf00297,6122,ENSG00000100316.15,RPL3,22,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
P15170-3,Isoform 3 of Eukaryotic peptide chain release factor GTP-binding subunit ERF3A OS=Homo sapiens OX=9606 GN=GSPT1,0,118.627,35,18,223,7,637,68.7,5.33,89481,1.61,18,2,cell organization and biogenesis;metabolic process,cytosol,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00009, Pf03143, Pf03144, Pf07145",2935,ENSG00000103342.12,GSPT1,16,,,,0,High,1
Q8WW22,DnaJ homolog subfamily A member 4 OS=Homo sapiens OX=9606 GN=DNAJA4 PE=1 SV=1,0,118.486,42,14,147,14,397,44.8,7.59,46882,126.14,9,6,metabolic process;regulation of biological process;response to stimulus,cytosol;membrane,metal ion binding;nucleotide binding;protein binding,"Pf00226, Pf00684, Pf01556",55466,ENSG00000140403.12,DNAJA4,15,,,HSP90 chaperone cycle for steroid hormone receptors (SHR),3,High,1
Q14738,Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform OS=Homo sapiens OX=9606 GN=PPP2R5D PE=1 SV=1,0,118.479,39,18,196,14,602,69.9,8.13,78261,18.77,18,2,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;enzyme regulator activity;protein binding,Pf01603,5528,ENSG00000112640.14,PPP2R5D,6,Dopaminergic synapse; Oocyte meiosis; Adrenergic signaling in cardiomyocytes; PI3K-Akt signaling pathway; mRNA surveillance pathway; Sphingolipid signaling pathway; AMPK signaling pathway,Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Glycogen Metabolism,"Glycolysis; ERKs are inactivated; Beta-catenin phosphorylation cascade; AXIN missense mutants destabilize the destruction complex; PP2A-mediated dephosphorylation of key metabolic factors; Negative regulation of MAPK pathway; APC truncation mutants have impaired AXIN binding; CTLA4 inhibitory signaling; Platelet sensitization by LDL; Activated TLR4 signalling; Signaling by GPCR; Separation of Sister Chromatids; Interleukin-20 family signaling; S37 mutants of beta-catenin aren't phosphorylated; DARPP-32 events; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; S33 mutants of beta-catenin aren't phosphorylated; Disassembly of the destruction complex and recruitment of AXIN to the membrane; S45 mutants of beta-catenin aren't phosphorylated; Misspliced GSK3beta mutants stabilize beta-catenin; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Resolution of Sister Chromatid Cohesion; T41 mutants of beta-catenin aren't phosphorylated; RHO GTPases Activate Formins; RAF activation; Truncations of AMER1 destabilize the destruction complex",100,High,1
Q16586,Alpha-sarcoglycan OS=Homo sapiens OX=9606 GN=SGCA PE=1 SV=1,0,118.435,33,9,268,9,387,42.8,5.86,112450,109.72,7,6,cell organization and biogenesis;response to stimulus,cytoplasm;cytoskeleton;membrane,metal ion binding;protein binding,Pf05510,6442,ENSG00000108823.15,SGCA,17,Hypertrophic cardiomyopathy (HCM); Arrhythmogenic right ventricular cardiomyopathy (ARVC); Viral myocarditis; Dilated cardiomyopathy,Arrhythmogenic Right Ventricular Cardiomyopathy,,5,High,1
O43741,5'-AMP-activated protein kinase subunit beta-2 OS=Homo sapiens OX=9606 GN=PRKAB2 PE=1 SV=1,0,118.383,57,11,197,10,272,30.3,6.46,85277,8.63,10,1,cell communication;metabolic process;regulation of biological process;response to stimulus;transport,cytosol,catalytic activity;protein binding,"Pf02922, Pf04739",5565,ENSG00000131791.7,LOC101060511; PRKAB2,1,Adipocytokine signaling pathway; AMPK signaling pathway; Longevity regulating pathway - multiple species; Circadian rhythm; Oxytocin signaling pathway; Longevity regulating pathway; Insulin signaling pathway; Insulin resistance; Non-alcoholic fatty liver disease (NAFLD); Glucagon signaling pathway; Hypertrophic cardiomyopathy (HCM); FoxO signaling pathway,AMP-activated Protein Kinase (AMPK) Signaling; Target Of Rapamycin (TOR) Signaling; Energy Metabolism; Sterol Regulatory Element-Binding Proteins (SREBP) signalling; Angiopoietin Like Protein 8 Regulatory Pathway,Translocation of GLUT4 to the plasma membrane; Energy dependent regulation of mTOR by LKB1-AMPK; Import of palmitoyl-CoA into the mitochondrial matrix; TP53 Regulates Metabolic Genes; Regulation of TP53 Activity through Phosphorylation; Macroautophagy; AMPK inhibits chREBP transcriptional activation activity; Activation of PPARGC1A (PGC-1alpha) by phosphorylation,41,High,1
P07203,Glutathione peroxidase 1 OS=Homo sapiens OX=9606 GN=GPX1 PE=1 SV=4,0,118.254,63,12,256,12,203,22.1,6.55,129314,22.23,10,3,cell death;cell differentiation;cell proliferation;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;mitochondrion;organelle lumen,antioxidant activity;catalytic activity;protein binding,Pf00255,2876,ENSG00000233276.3,GPX1,3,Arachidonic acid metabolism; Amyotrophic lateral sclerosis (ALS); Huntington's disease; Thyroid hormone synthesis; Glutathione metabolism,Glutathione metabolism; Selenium Micronutrient Network; Folate Metabolism; Amyotrophic lateral sclerosis (ALS); Selenium Metabolism and Selenoproteins; Association Between Physico-Chemical Features and Toxicity Associated Pathways; One carbon metabolism and related pathways; TYROBP Causal Network; Oxidative Stress,Synthesis of 12-eicosatetraenoic acid derivatives; Synthesis of 15-eicosatetraenoic acid derivatives; Detoxification of Reactive Oxygen Species; Synthesis of 5-eicosatetraenoic acids; Purine catabolism,27,High,1
Q13347,Eukaryotic translation initiation factor 3 subunit I OS=Homo sapiens OX=9606 GN=EIF3I PE=1 SV=1,0,118.068,45,13,194,13,325,36.5,5.64,87374,4,13,1,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol,protein binding;RNA binding,Pf00400,8668,ENSG00000084623.11,EIF3I,1,RNA transport,Translation Factors,"Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Ribosomal scanning and start codon recognition",13,High,1
Q8IW45,ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Homo sapiens OX=9606 GN=NAXD PE=1 SV=1,0,117.814,44,12,199,12,347,36.6,8.06,104149,2.49,11,2,metabolic process,mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding,Pf01256,55739,,CARKD; NAXD,13,,,Nicotinamide salvaging,5,High,1
Q9UPT5,Exocyst complex component 7 OS=Homo sapiens OX=9606 GN=EXOC7 PE=1 SV=3,0,117.797,38,22,110,22,735,83.3,6.79,47198,,22,,regulation of biological process;transport,cytoplasm;cytosol;membrane,protein binding,Pf03081,23265,ENSG00000182473.21,EXOC7,17,Insulin signaling pathway,Angiopoietin Like Protein 8 Regulatory Pathway,Translocation of GLUT4 to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium,12,High,1
Q9P2R3,Rabankyrin-5 OS=Homo sapiens OX=9606 GN=ANKFY1 PE=1 SV=2,0,117.753,23,18,107,18,1169,128.3,6.1,47791,0,18,1,cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytosol;endosome;membrane,metal ion binding;protein binding,"Pf00023, Pf00651, Pf01363, Pf07707, Pf12796, Pf13606, Pf13637, Pf13857",51479,ENSG00000185722.16,ANKFY1,17,,,,0,High,1
O95870,Phosphatidylserine lipase ABHD16A OS=Homo sapiens OX=9606 GN=ABHD16A PE=1 SV=3,0,117.665,33,17,204,17,558,63.2,8.13,89339,,17,,metabolic process,membrane,catalytic activity;protein binding,"Pf00561, Pf12695, Pf12697",7920,ENSG00000204427.11; ENSG00000206403.11,ABHD16A,6; CHR_HSCHR6_MHC_QBL_CTG1,,,,0,High,1
Q6P587,"Acylpyruvase FAHD1, mitochondrial OS=Homo sapiens OX=9606 GN=FAHD1 PE=1 SV=2",0,117.634,44,9,374,9,224,24.8,7.39,172037,0,9,1,metabolic process,cytoplasm;cytosol;membrane;mitochondrion,catalytic activity;metal ion binding,Pf01557,81889,ENSG00000180185.11,FAHD1,16,Tyrosine metabolism; Metabolic pathways,,,2,High,1
Q9H2M9,Rab3 GTPase-activating protein non-catalytic subunit OS=Homo sapiens OX=9606 GN=RAB3GAP2 PE=1 SV=1,0,117.608,18,21,84,21,1393,155.9,5.62,38525,,21,,regulation of biological process;transport,cytoplasm;cytosol;membrane,enzyme regulator activity;protein binding,"Pf14655, Pf14656",25782,ENSG00000118873.15,RAB3GAP2,1,,,COPI-independent Golgi-to-ER retrograde traffic; RAB GEFs exchange GTP for GDP on RABs,7,High,1
O75663,TIP41-like protein OS=Homo sapiens OX=9606 GN=TIPRL PE=1 SV=2,0,117.592,57,12,170,12,272,31.4,5.91,69460,17.82,12,1,regulation of biological process;response to stimulus,cytoplasm,protein binding,Pf04176,261726,ENSG00000143155.12,TIPRL,1,,,,0,High,1
Q9Y3P9,Rab GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RABGAP1 PE=1 SV=3,0,117.551,23,20,100,17,1069,121.7,5.25,42821,,20,,regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol,enzyme regulator activity;protein binding,"Pf00566, Pf00640, Pf02463, Pf12473, Pf13870",23637,ENSG00000011454.16,RABGAP1,9,,,TBC/RABGAPs,4,High,1
Q03135,Caveolin-1 OS=Homo sapiens OX=9606 GN=CAV1 PE=1 SV=4,0,117.501,51,15,515,11,178,20.5,6.02,251800,0,15,2,cell communication;cell differentiation;cell organization and biogenesis;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;endosome;Golgi;membrane,enzyme regulator activity;protein binding;structural molecule activity,Pf01146,857,ENSG00000105974.11,CAV1,7,Proteoglycans in cancer; Bacterial invasion of epithelial cells; Endocytosis; Viral myocarditis; Focal adhesion,Androgen receptor signaling pathway; Integrin-mediated Cell Adhesion; Focal Adhesion; TGF-beta Signaling Pathway; VEGFA-VEGFR2 Signaling Pathway; EGF/EGFR Signaling Pathway,Triglyceride catabolism; Basigin interactions; eNOS activation; NOSTRIN mediated eNOS trafficking; Disassembly of the destruction complex and recruitment of AXIN to the membrane; VEGFR2 mediated vascular permeability,30,High,1
P42167,"Lamina-associated polypeptide 2, isoforms beta/gamma OS=Homo sapiens OX=9606 GN=TMPO PE=1 SV=2",0,117.363,40,13,126,6,454,50.6,9.38,59911,,13,,regulation of biological process,chromosome;cytoplasm;membrane;nucleus,DNA binding;protein binding,"Pf03020, Pf08198",7112,ENSG00000120802.13,TMPO,12,,,Depolymerisation of the Nuclear Lamina; Initiation of Nuclear Envelope Reformation; Clearance of Nuclear Envelope Membranes from Chromatin,11,High,1
Q9Y217,Myotubularin-related protein 6 OS=Homo sapiens OX=9606 GN=MTMR6 PE=1 SV=3,0,117.301,41,21,125,21,621,71.9,7.66,44151,8.66,20,4,metabolic process;transport,cytoplasm;cytosol;nucleus,catalytic activity;protein binding;receptor activity;signal transducer activity;transporter activity,Pf06602,9107,ENSG00000139505.11,MTMR6,13,Metabolic pathways; Phosphatidylinositol signaling system; Inositol phosphate metabolism,,Synthesis of PIPs at the plasma membrane,8,High,1
P55265,Double-stranded RNA-specific adenosine deaminase OS=Homo sapiens OX=9606 GN=ADAR PE=1 SV=4,0,117.124,20,19,125,19,1226,136,8.65,54863,0,19,1,cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;membrane;nucleus;spliceosomal complex,catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding,"Pf00035, Pf02137, Pf02295",103,ENSG00000160710.15,ADAR,1,Influenza A; Cytosolic DNA-sensing pathway; Measles,,C6 deamination of adenosine; Interferon alpha/beta signaling; Formation of editosomes by ADAR proteins,12,High,1
Q96CM8,"Medium-chain acyl-CoA ligase ACSF2, mitochondrial OS=Homo sapiens OX=9606 GN=ACSF2 PE=1 SV=2",0,117.114,24,13,195,13,615,68.1,7.55,93137,0,13,1,metabolic process,mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding,"Pf00501, Pf13193",80221,ENSG00000167107.12,ACSF2,17,,Mitochondrial LC-Fatty Acid Beta-Oxidation,Mitochondrial Fatty Acid Beta-Oxidation,5,High,1
Q6DD88,Atlastin-3 OS=Homo sapiens OX=9606 GN=ATL3 PE=1 SV=1,0,117.064,45,18,140,18,541,60.5,5.66,52618,0,18,1,cell organization and biogenesis;regulation of biological process;transport,endoplasmic reticulum;membrane,catalytic activity;nucleotide binding;protein binding,Pf02263,25923,ENSG00000184743.12,ATL3,11,,,,0,High,1
Q99707,Methionine synthase OS=Homo sapiens OX=9606 GN=MTR PE=1 SV=2,0,116.878,23,21,93,21,1265,140.4,5.58,35396,0,21,1,cell organization and biogenesis;metabolic process;response to stimulus,cytoplasm;cytosol,catalytic activity;metal ion binding;protein binding,"Pf00809, Pf02310, Pf02574, Pf02607, Pf02965, Pf03599",4548,ENSG00000116984.12,MTR,1,Selenocompound metabolism; Metabolic pathways; Biosynthesis of amino acids; Cysteine and methionine metabolism; One carbon pool by folate,Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism; Trans-sulfuration pathway; One Carbon Metabolism; Trans-sulfuration and one carbon metabolism; One carbon metabolism and related pathways,"Defective MTR causes methylmalonic aciduria and homocystinuria type cblG; Sulfur amino acid metabolism; Methylation; Cobalamin (Cbl, vitamin B12) transport and metabolism; Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE",27,High,1
Q58FG0,Putative heat shock protein HSP 90-alpha A5 OS=Homo sapiens OX=9606 GN=HSP90AA5P PE=2 SV=1,0,116.863,18,13,426,1,334,38.7,6.57,213339,2.21,13,2,metabolic process;response to stimulus,cytoplasm,nucleotide binding;protein binding,Pf00183,730211,,HSP90AA5P,3,,,,0,High,1
P49023,Paxillin OS=Homo sapiens OX=9606 GN=PXN PE=1 SV=3,0,116.562,31,11,190,4,591,64.5,6.19,91550,0,11,1,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane,DNA binding;metal ion binding;protein binding;transporter activity,"Pf00412, Pf03535",5829,ENSG00000089159.16,PXN,12,Proteoglycans in cancer; Viral carcinogenesis; Leukocyte transendothelial migration; Focal adhesion; Bacterial invasion of epithelial cells; Chemokine signaling pathway; Regulation of actin cytoskeleton; VEGF signaling pathway,Integrin-mediated Cell Adhesion; Prolactin Signaling Pathway; Oncostatin M Signaling Pathway; Focal Adhesion; Signaling of Hepatocyte Growth Factor Receptor; Rac1/Pak1/p38/MMP-2 pathway; VEGFA-VEGFR2 Signaling Pathway; Chemokine signaling pathway; Regulation of Actin Cytoskeleton,"Localization of the PINCH-ILK-PARVIN complex to focal adhesions; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; Smooth Muscle Contraction; VEGFA-VEGFR2 Pathway; GAB1 signalosome; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components",33,High,1
P04439,"HLA class I histocompatibility antigen, A alpha chain OS=Homo sapiens OX=9606 GN=HLA-A PE=1 SV=2",0,116.378,39,13,188,9,365,40.8,6,98998,0,13,1,metabolic process;regulation of biological process;response to stimulus,cell surface;endoplasmic reticulum;Golgi;membrane,protein binding;RNA binding,"Pf00129, Pf07654",3105,ENSG00000206503.12,HLA-A,6,,Proteasome Degradation; Allograft Rejection,"Interferon alpha/beta signaling; E3 ubiquitin ligases ubiquitinate target proteins; Endosomal/Vacuolar pathway; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Interferon gamma signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; ER-Phagosome pathway",18,High,1
P55209,Nucleosome assembly protein 1-like 1 OS=Homo sapiens OX=9606 GN=NAP1L1 PE=1 SV=1,0,116.366,30,10,266,8,391,45.3,4.46,136836,0,10,1,cell organization and biogenesis;metabolic process;regulation of biological process,membrane;nucleus,protein binding;RNA binding,Pf00956,4673,ENSG00000187109.13,NAP1L1,12,,,,0,High,1
Q9NZJ6,"Ubiquinone biosynthesis O-methyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=COQ3 PE=1 SV=3",0,116.328,30,11,447,11,369,41,7.42,207698,0,10,2,metabolic process;regulation of biological process,membrane;mitochondrion;organelle lumen,catalytic activity,"Pf01209, Pf02353, Pf03291, Pf05175, Pf05401, Pf05891, Pf06325, Pf08003, Pf08241, Pf08242, Pf12847, Pf13489, Pf13649, Pf13659, Pf13847",51805,ENSG00000132423.11,COQ3,6,Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways,,Ubiquinol biosynthesis,6,High,1
O14561,"Acyl carrier protein, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFAB1 PE=1 SV=3",0,116.324,30,11,773,11,156,17.4,4.93,365385,66.15,9,3,cell organization and biogenesis;metabolic process;transport,cytosol;membrane;mitochondrion;organelle lumen,catalytic activity;metal ion binding;protein binding;transporter activity,Pf00550,4706,ENSG00000004779.9,NDUFAB1,16,Non-alcoholic fatty liver disease (NAFLD); Huntington's disease; Alzheimer's disease; Metabolic pathways; Oxidative phosphorylation; Parkinson's disease,Electron Transport Chain; Oxidative phosphorylation,Mitochondrial Fatty Acid Beta-Oxidation; Glyoxylate metabolism and glycine degradation; Complex I biogenesis,18,High,1
Q7Z2K6,Endoplasmic reticulum metallopeptidase 1 OS=Homo sapiens OX=9606 GN=ERMP1 PE=1 SV=2,0,116.29,28,19,107,19,904,100.2,7.52,45676,1.62,19,2,metabolic process,endoplasmic reticulum;membrane,catalytic activity;metal ion binding,Pf04389,79956,ENSG00000099219.13,ERMP1,9,,,,0,High,1
O75251,"NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS7 PE=1 SV=3",0,116.195,38,10,837,10,213,23.5,9.99,439579,0,10,2,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion;organelle lumen,catalytic activity;metal ion binding;protein binding,Pf01058,374291,ENSG00000115286.19,NDUFS7,19,Huntington's disease; Metabolic pathways; Alzheimer's disease; Non-alcoholic fatty liver disease (NAFLD); Parkinson's disease; Oxidative phosphorylation,Electron Transport Chain; Oxidative phosphorylation,Complex I biogenesis,13,High,1
P25788,Proteasome subunit alpha type-3 OS=Homo sapiens OX=9606 GN=PSMA3 PE=1 SV=2,0,116.189,45,12,304,12,255,28.4,5.33,144019,1.65,12,4,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus;proteasome,catalytic activity;nucleotide binding;protein binding,"Pf00227, Pf10584",5684,ENSG00000100567.12,PSMA3,14,Proteasome,Proteasome Degradation,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,150,High,1
Q8TCJ2,Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B OS=Homo sapiens OX=9606 GN=STT3B PE=1 SV=1,0,116.157,19,16,132,14,826,93.6,8.91,61210,0,16,1,metabolic process;response to stimulus,endoplasmic reticulum;membrane,catalytic activity;metal ion binding,"Pf02516, Pf13231",201595,ENSG00000163527.9,STT3B,3,Protein processing in endoplasmic reticulum; Metabolic pathways; N-Glycan biosynthesis,,,3,High,1
P29218,Inositol monophosphatase 1 OS=Homo sapiens OX=9606 GN=IMPA1 PE=1 SV=1,0,116.091,38,10,210,10,277,30.2,5.26,104005,0,10,2,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,catalytic activity;metal ion binding;protein binding,Pf00459,3612,ENSG00000133731.9,IMPA1,8,Inositol phosphate metabolism; Phosphatidylinositol signaling system; Metabolic pathways,Integrated Breast Cancer Pathway,"Synthesis of IP2, IP, and Ins in the cytosol",7,High,1
Q9NRY5,Protein FAM114A2 OS=Homo sapiens OX=9606 GN=FAM114A2 PE=1 SV=4,0,116.035,42,14,103,14,505,55.4,4.88,42288,4.51,14,2,,,nucleotide binding,Pf05334,10827,ENSG00000055147.18,FAM114A2,5,,,Signaling by BRAF and RAF fusions,4,High,1
Q9HDC9,Adipocyte plasma membrane-associated protein OS=Homo sapiens OX=9606 GN=APMAP PE=1 SV=2,0,115.993,45,14,227,14,416,46.5,6.16,99471,,14,,metabolic process,cell surface;endoplasmic reticulum;membrane,catalytic activity,"Pf03088, Pf08450",57136,ENSG00000101474.11,APMAP,20,,,,0,High,1
Q9UQE7,Structural maintenance of chromosomes protein 3 OS=Homo sapiens OX=9606 GN=SMC3 PE=1 SV=2,0,115.911,26,25,96,25,1217,141.5,7.18,36881,,25,,cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,chromosome;cytosol;nucleus,catalytic activity;motor activity;nucleotide binding;protein binding;transporter activity,"Pf01496, Pf02463, Pf04111, Pf06470, Pf10168, Pf12128, Pf13304, Pf13476, Pf13555",9126,ENSG00000108055.9,SMC3,10,Oocyte meiosis; Cell cycle,Retinoblastoma (RB) in Cancer; Mecp2 and Associated Rett Syndrome,Meiotic synapsis; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin; Establishment of Sister Chromatid Cohesion; SUMOylation of DNA damage response and repair proteins,24,High,1
Q86WA6,Valacyclovir hydrolase OS=Homo sapiens OX=9606 GN=BPHL PE=1 SV=1,0,115.893,52,12,248,12,291,32.5,9.14,115909,0,11,4,metabolic process;response to stimulus,membrane;mitochondrion,catalytic activity,"Pf00561, Pf01738, Pf12695, Pf12697",670,ENSG00000137274.12,BPHL,6,,,Phase I - Functionalization of compounds,3,High,1
Q96AQ6,Pre-B-cell leukemia transcription factor-interacting protein 1 OS=Homo sapiens OX=9606 GN=PBXIP1 PE=1 SV=1,0,115.812,24,14,124,14,731,80.6,5.33,61725,0,14,2,cell differentiation;development;regulation of biological process,cytoplasm;cytoskeleton;cytosol;nucleus,protein binding,,57326,ENSG00000163346.16,PBXIP1,1,,,,0,High,1
P11413,Glucose-6-phosphate 1-dehydrogenase OS=Homo sapiens OX=9606 GN=G6PD PE=1 SV=4,0,115.804,41,20,127,20,515,59.2,6.84,53567,,20,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00479, Pf02781",2539,ENSG00000160211.15,G6PD,X,Metabolic pathways; Glutathione metabolism; Central carbon metabolism in cancer; Pentose phosphate pathway; Carbon metabolism,Glutathione metabolism; Pentose Phosphate Pathway; Cori Cycle; NRF2 pathway; ATM Signaling Network in Development and Disease; Sulfation Biotransformation Reaction,TP53 Regulates Metabolic Genes; Pentose phosphate pathway (hexose monophosphate shunt),19,High,1
O60841,Eukaryotic translation initiation factor 5B OS=Homo sapiens OX=9606 GN=EIF5B PE=1 SV=4,0,115.762,20,19,142,19,1220,138.7,5.49,59224,,19,,metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding,"Pf00009, Pf01926, Pf03144, Pf11987, Pf14578",9669,ENSG00000158417.10,EIF5B,2,RNA transport,Translation Factors,GTP hydrolysis and joining of the 60S ribosomal subunit,7,High,1
P49755,Transmembrane emp24 domain-containing protein 10 OS=Homo sapiens OX=9606 GN=TMED10 PE=1 SV=2,0,115.737,37,9,261,9,219,25,7.44,132502,0,9,2,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;Golgi;membrane,protein binding,Pf01105,10972,ENSG00000170348.8,TMED10,14,,mRNA Processing,COPI-dependent Golgi-to-ER retrograde traffic; Cargo concentration in the ER; COPII (Coat Protein 2) Mediated Vesicle Transport; COPI-mediated anterograde transport,14,High,1
P03886,NADH-ubiquinone oxidoreductase chain 1 OS=Homo sapiens OX=9606 GN=MT-ND1 PE=1 SV=1,0,115.67,13,7,486,7,318,35.6,6.55,235347,8.28,6,1,cell organization and biogenesis;metabolic process;response to stimulus;transport,membrane;mitochondrion,catalytic activity;protein binding,Pf00146,4535,ENSG00000198888.2,ND1,MT,Metabolic pathways; Oxidative phosphorylation; Parkinson's disease,Electron Transport Chain; Oxidative phosphorylation,Complex I biogenesis,10,High,1
Q9NX63,MICOS complex subunit MIC19 OS=Homo sapiens OX=9606 GN=CHCHD3 PE=1 SV=1,0,115.657,33,12,336,12,227,26.1,8.28,160712,11.21,11,3,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;membrane;mitochondrion;nucleus,protein binding;structural molecule activity,"Pf05300, Pf06747",54927,ENSG00000106554.11,CHCHD3,7,,,Cristae formation; Mitochondrial protein import; Metabolism of proteins,5,High,1
Q9Y6D5,Brefeldin A-inhibited guanine nucleotide-exchange protein 2 OS=Homo sapiens OX=9606 GN=ARFGEF2 PE=1 SV=3,0,115.417,16,22,79,15,1785,201.9,6.33,31101,,22,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endosome;Golgi;membrane,protein binding,"Pf01369, Pf09324, Pf12783",10564,ENSG00000124198.8,ARFGEF2,20,Endocytosis,,Association of TriC/CCT with target proteins during biosynthesis,5,High,1
Q15404,Ras suppressor protein 1 OS=Homo sapiens OX=9606 GN=RSU1 PE=1 SV=3,0,115.341,51,11,389,11,277,31.5,8.65,179042,,11,,regulation of biological process;response to stimulus,cytosol,protein binding,Pf08757,6251,ENSG00000148484.17,RSU1,10,,,Regulation of cytoskeletal remodeling and cell spreading by IPP complex components,4,High,1
P04004,Vitronectin OS=Homo sapiens OX=9606 GN=VTN PE=1 SV=1,0,115.266,26,13,417,13,478,54.3,5.8,207831,,13,,cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;extracellular;organelle lumen,protein binding;receptor activity,"Pf00045, Pf01033",7448,ENSG00000109072.13,VTN,17,Complement and coagulation cascades; PI3K-Akt signaling pathway; Proteoglycans in cancer; ECM-receptor interaction; Focal adhesion,Primary Focal Segmental Glomerulosclerosis FSGS; Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Inflammatory Response Pathway; Senescence and Autophagy in Cancer,ECM proteoglycans; Integrin cell surface interactions; Molecules associated with elastic fibres; Regulation of Complement cascade; Syndecan interactions,21,High,1
P48506,Glutamate--cysteine ligase catalytic subunit OS=Homo sapiens OX=9606 GN=GCLC PE=1 SV=2,0,115.264,32,18,153,18,637,72.7,6.09,70497,0,18,1,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cytosol,catalytic activity;metal ion binding;nucleotide binding;protein binding,Pf03074,2729,ENSG00000001084.10,GCLC,6,Glutathione metabolism; Cysteine and methionine metabolism; Metabolic pathways,Glutathione metabolism; Trans-sulfuration and one carbon metabolism; Aryl Hydrocarbon Receptor; Apoptosis-related network due to altered Notch3 in ovarian cancer; NRF2 pathway; Transcriptional activation by NRF2; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; One carbon metabolism and related pathways; Oxidative Stress,Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD); Glutathione synthesis and recycling,21,High,1
P05546,Heparin cofactor 2 OS=Homo sapiens OX=9606 GN=SERPIND1 PE=1 SV=3,0,115.226,30,15,202,14,499,57,6.9,95121,3.34,15,4,coagulation;metabolic process;regulation of biological process;response to stimulus,extracellular;organelle lumen,enzyme regulator activity,Pf00079,3053,ENSG00000099937.10,SERPIND1,22,Complement and coagulation cascades,Complement and Coagulation Cascades,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Common Pathway of Fibrin Clot Formation; Intrinsic Pathway of Fibrin Clot Formation,10,High,1
Q04917,14-3-3 protein eta OS=Homo sapiens OX=9606 GN=YWHAH PE=1 SV=4,0,115.16,44,12,875,8,246,28.2,4.84,466650,0,12,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;mitochondrion,catalytic activity;protein binding,Pf00244,7533,ENSG00000128245.14,YWHAH,22,Epstein-Barr virus infection; Oocyte meiosis; Viral carcinogenesis; PI3K-Akt signaling pathway; Hippo signaling pathway; Cell cycle,Cell Cycle; Myometrial Relaxation and Contraction Pathways; Calcium Regulation in the Cardiac Cell; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,Translocation of GLUT4 to the plasma membrane; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; TP53 Regulates Metabolic Genes; Activation of BAD and translocation to mitochondria ; RHO GTPases activate PKNs,32,High,1
Q9UNF0,Protein kinase C and casein kinase substrate in neurons protein 2 OS=Homo sapiens OX=9606 GN=PACSIN2 PE=1 SV=2,0,115.007,31,14,152,14,486,55.7,5.2,69876,5.32,13,2,cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;endosome;membrane,protein binding;transporter activity,"Pf00018, Pf00611, Pf07653, Pf14604",11252,ENSG00000100266.18,PACSIN2,22,,,Clathrin-mediated endocytosis,3,High,1
Q13098,COP9 signalosome complex subunit 1 OS=Homo sapiens OX=9606 GN=GPS1 PE=1 SV=4,0,114.92,34,15,180,15,491,55.5,6.74,84154,0,15,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,enzyme regulator activity;protein binding,"Pf01399, Pf10602",2873,ENSG00000169727.12,GPS1,17,,,Cargo recognition for clathrin-mediated endocytosis; DNA Damage Recognition in GG-NER; Formation of TC-NER Pre-Incision Complex; Neddylation,13,High,1
Q96FW1,Ubiquitin thioesterase OTUB1 OS=Homo sapiens OX=9606 GN=OTUB1 PE=1 SV=2,0,114.87,49,11,279,11,271,31.3,4.94,142054,1.75,10,2,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf02338, Pf10275",55611,ENSG00000167770.11,OTUB1,11,,,Ovarian tumor domain proteases; Ub-specific processing proteases,5,High,1
P21695,"Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic OS=Homo sapiens OX=9606 GN=GPD1 PE=1 SV=4",0,114.834,43,14,183,13,349,37.5,6.18,88238,0,14,1,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;mitochondrion,catalytic activity;nucleotide binding;protein binding,"Pf01210, Pf07479",2819,ENSG00000167588.12,GPD1,12,Glycerophospholipid metabolism,Triacylglyceride Synthesis,Synthesis of PA,7,High,1
Q8N0Y7,Probable phosphoglycerate mutase 4 OS=Homo sapiens OX=9606 GN=PGAM4 PE=3 SV=1,0,114.791,42,11,730,1,254,28.8,6.65,393822,0,11,3,metabolic process;regulation of biological process,cytosol,catalytic activity,Pf00300,441531,ENSG00000226784.2,PGAM4,X,"Carbon metabolism; Glycolysis / Gluconeogenesis; Metabolic pathways; Glycine, serine and threonine metabolism; Central carbon metabolism in cancer; Biosynthesis of amino acids; Glucagon signaling pathway",,,7,High,1
P13611,Versican core protein OS=Homo sapiens OX=9606 GN=VCAN PE=1 SV=3,0,114.749,4,13,168,13,3396,372.6,4.51,76671,0,13,1,cell differentiation;cell organization and biogenesis;cellular component movement;development;metabolic process,extracellular;membrane;organelle lumen,metal ion binding;protein binding;structural molecule activity,"Pf00008, Pf00059, Pf00084, Pf00193, Pf07645, Pf12947",1462,ENSG00000038427.15,VCAN,5,Cell adhesion molecules (CAMs),Spinal Cord Injury,"ECM proteoglycans; Post-translational protein phosphorylation; A tetrasaccharide linker sequence is required for GAG synthesis; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Dermatan sulfate biosynthesis; Defective CHSY1 causes TPBS; Defective B4GALT7 causes EDS, progeroid type; Defective B3GALT6 causes EDSP2 and SEMDJL1; CS/DS degradation; Defective CHST14 causes EDS, musculocontractural type; Defective CHST3 causes SEDCJD; Chondroitin sulfate biosynthesis; Defective B3GAT3 causes JDSSDHD",26,High,1
Q9Y2E4,Disco-interacting protein 2 homolog C OS=Homo sapiens OX=9606 GN=DIP2C PE=1 SV=2,0,114.618,18,23,130,18,1556,170.7,7.39,53081,2.8,23,2,metabolic process,,catalytic activity,"Pf00501, Pf06464",22982,ENSG00000151240.16,DIP2C,10,,,,0,High,1
Q14108,Lysosome membrane protein 2 OS=Homo sapiens OX=9606 GN=SCARB2 PE=1 SV=2,0,114.461,34,14,226,13,478,54.3,5.14,101761,0,14,1,cell organization and biogenesis;regulation of biological process;transport,membrane;organelle lumen;vacuole,protein binding;receptor activity,Pf01130,950,ENSG00000138760.9,SCARB2,4,Lysosome,Primary Focal Segmental Glomerulosclerosis FSGS,Cargo recognition for clathrin-mediated endocytosis,6,High,1
Q8NFP9,Neurobeachin OS=Homo sapiens OX=9606 GN=NBEA PE=1 SV=3,0,114.35,10,21,120,16,2946,327.6,6.18,48530,8.5,19,3,,cytoplasm;cytosol;membrane,protein binding,"Pf02138, Pf06469, Pf13385, Pf14844",26960,ENSG00000172915.18,NBEA,13,,,,0,High,1
Q07666,"KH domain-containing, RNA-binding, signal transduction-associated protein 1 OS=Homo sapiens OX=9606 GN=KHDRBS1 PE=1 SV=1",0,114.346,24,7,276,6,443,48.2,8.66,134644,0,7,1,cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,DNA binding;protein binding;RNA binding,"Pf00013, Pf13014",10657,ENSG00000121774.17,KHDRBS1,1,,Leptin signaling pathway,PTK6 Regulates Proteins Involved in RNA Processing,5,High,1
Q9HAV7,"GrpE protein homolog 1, mitochondrial OS=Homo sapiens OX=9606 GN=GRPEL1 PE=1 SV=2",0,114.249,50,11,287,11,217,24.3,8.12,130860,0,11,1,metabolic process;regulation of biological process;transport,mitochondrion;nucleus;organelle lumen,enzyme regulator activity;nucleotide binding;protein binding,Pf01025,80273,ENSG00000109519.12,GRPEL1,4,,,Mitochondrial protein import; Metabolism of proteins,2,High,1
P20073,Annexin A7 OS=Homo sapiens OX=9606 GN=ANXA7 PE=1 SV=3,0,114.179,24,12,348,10,488,52.7,5.68,163361,2.3,12,5,cell differentiation;cell organization and biogenesis;cell proliferation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cytosol;membrane;nucleus,metal ion binding;protein binding;RNA binding,Pf00191,310,ENSG00000138279.15,ANXA7,10,,,,0,High,1
Q9BTZ2,Dehydrogenase/reductase SDR family member 4 OS=Homo sapiens OX=9606 GN=DHRS4 PE=1 SV=3,0,114.156,40,14,299,6,278,29.5,8.56,154564,1.98,14,2,cell organization and biogenesis;metabolic process,membrane;mitochondrion;nucleus,catalytic activity;protein binding,"Pf00106, Pf08659, Pf13561",10901,ENSG00000157326.18,DHRS4,14,Metabolic pathways; Peroxisome; Retinol metabolism,,RA biosynthesis pathway,7,High,1
Q13033,Striatin-3 OS=Homo sapiens OX=9606 GN=STRN3 PE=1 SV=3,0,114.124,27,16,105,1,797,87.2,5.36,44854,2.25,16,2,regulation of biological process;response to stimulus,cytoplasm;Golgi;membrane;nucleus,protein binding,"Pf00400, Pf08232",29966,ENSG00000196792.11,STRN3,14,,,,0,High,1
Q8WUD1,Ras-related protein Rab-2B OS=Homo sapiens OX=9606 GN=RAB2B PE=1 SV=1,0,114.098,60,11,207,4,216,24.2,7.83,97355,1.67,11,3,regulation of biological process;response to stimulus;transport,endoplasmic reticulum;Golgi;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf01926, Pf08477",84932,ENSG00000129472.13,RAB2B,14,,,RAB geranylgeranylation,3,High,1
Q7Z7G0,Target of Nesh-SH3 OS=Homo sapiens OX=9606 GN=ABI3BP PE=1 SV=1,0,114.093,16,15,152,15,1075,118.6,9.44,61199,6.31,14,3,cell organization and biogenesis;regulation of biological process,extracellular,protein binding,Pf00041,25890,ENSG00000154175.16,ABI3BP,3,,,,0,High,1
P00747,Plasminogen OS=Homo sapiens OX=9606 GN=PLG PE=1 SV=2,0,114.021,19,16,170,15,810,90.5,7.24,78439,15.15,13,4,cell differentiation;cell organization and biogenesis;cellular component movement;cellular homeostasis;coagulation;metabolic process;regulation of biological process;transport,cell surface;extracellular;membrane;organelle lumen,catalytic activity;protein binding,"Pf00024, Pf00051, Pf00089, Pf09342, Pf13365",5340,ENSG00000122194.18,PLG,6,Complement and coagulation cascades; Influenza A; Staphylococcus aureus infection; Neuroactive ligand-receptor interaction,Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism; Blood Clotting Cascade; Complement and Coagulation Cascades,Platelet degranulation ; Dissolution of Fibrin Clot; Activation of Matrix Metalloproteinases; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Signaling by PDGF,22,High,1
Q8IXI2,Mitochondrial Rho GTPase 1 OS=Homo sapiens OX=9606 GN=RHOT1 PE=1 SV=2,0,113.993,31,16,209,15,618,70.7,6.27,99757,0,16,2,cell organization and biogenesis;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;membrane;mitochondrion,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00071, Pf08355, Pf08356, Pf08477",55288,ENSG00000126858.16,RHOT1,17,,,Ub-specific processing proteases; Rho GTPase cycle,7,High,1
P08648,Integrin alpha-5 OS=Homo sapiens OX=9606 GN=ITGA5 PE=1 SV=2,0,113.947,23,16,93,16,1049,114.5,5.77,40886,,16,,cell differentiation;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cell surface;cytoplasm;endoplasmic reticulum;Golgi;membrane,metal ion binding;protein binding;receptor activity,"Pf01839, Pf08441",3678,ENSG00000161638.10,ITGA5,12,Pertussis; Arrhythmogenic right ventricular cardiomyopathy (ARVC); PI3K-Akt signaling pathway; Proteoglycans in cancer; Hematopoietic cell lineage; Bacterial invasion of epithelial cells; Phagosome; Hypertrophic cardiomyopathy (HCM); MicroRNAs in cancer; ECM-receptor interaction; Dilated cardiomyopathy; Regulation of actin cytoskeleton; Focal adhesion; Shigellosis,Integrin-mediated Cell Adhesion; Arrhythmogenic Right Ventricular Cardiomyopathy; Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,RUNX2 regulates genes involved in cell migration; Integrin cell surface interactions; Signal transduction by L1; Elastic fibre formation; Fibronectin matrix formation; Cell surface interactions at the vascular wall,33,High,1
Q641Q2,WASH complex subunit 2A OS=Homo sapiens OX=9606 GN=WASHC2A PE=1 SV=3,0,113.932,21,18,85,1,1341,147.1,4.81,38024,2.56,18,1,transport,cytosol;endosome;membrane,,Pf15255,387680,ENSG00000099290.15,FAM21A; WASHC2A,10,Endocytosis,,,1,High,1
P21953,"2-oxoisovalerate dehydrogenase subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=BCKDHB PE=1 SV=2",0,113.854,38,8,228,8,392,43.1,6.29,114322,8.18,6,2,metabolic process,mitochondrion;organelle lumen,catalytic activity;protein binding,"Pf02779, Pf02780",594,ENSG00000083123.14,BCKDHB,6,"Valine, leucine and isoleucine degradation; Metabolic pathways; Propanoate metabolism",,Branched-chain amino acid catabolism; Glyoxylate metabolism and glycine degradation,7,High,1
Q5R372,Rab GTPase-activating protein 1-like OS=Homo sapiens OX=9606 GN=RABGAP1L PE=1 SV=1,0,113.808,28,18,139,16,815,92.5,5.31,56371,0,18,1,regulation of biological process;transport,endosome;Golgi;nucleus,enzyme regulator activity;protein binding,"Pf00566, Pf00640, Pf12473",9910,ENSG00000152061.23,RABGAP1L,1,,,,0,High,1
Q9BSH4,Translational activator of cytochrome c oxidase 1 OS=Homo sapiens OX=9606 GN=TACO1 PE=1 SV=1,0,113.802,39,11,193,11,297,32.5,8.13,93371,,11,,regulation of biological process,mitochondrion;nucleus,protein binding,Pf01709,51204,ENSG00000136463.7,TACO1,17,,,TP53 Regulates Metabolic Genes; Respiratory electron transport,9,High,1
Q96DB5,Regulator of microtubule dynamics protein 1 OS=Homo sapiens OX=9606 GN=RMDN1 PE=1 SV=1,0,113.659,39,12,388,12,314,35.8,8.5,177237,,12,,,cytoplasm;cytoskeleton;mitochondrion,protein binding,,51115,ENSG00000176623.11,FAM82B; RMDN1,8,,,,0,High,1
P00491,Purine nucleoside phosphorylase OS=Homo sapiens OX=9606 GN=PNP PE=1 SV=2,0,113.581,55,12,196,12,289,32.1,6.95,87433,0,12,1,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;extracellular;nucleus;organelle lumen,catalytic activity,Pf01048,4860,ENSG00000198805.11,PNP,14,Pyrimidine metabolism; Purine metabolism; Nicotinate and nicotinamide metabolism; Metabolic pathways,,Neutrophil degranulation; Purine salvage; Purine catabolism,13,High,1
Q15746,"Myosin light chain kinase, smooth muscle OS=Homo sapiens OX=9606 GN=MYLK PE=1 SV=4",0,113.525,12,17,163,17,1914,210.6,6.15,69199,2.02,17,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00041, Pf00047, Pf00069, Pf07679, Pf07714, Pf08205, Pf13895, Pf13927",4638,ENSG00000065534.18,MYLK,3,Regulation of actin cytoskeleton; Vascular smooth muscle contraction; Platelet activation; Oxytocin signaling pathway; Gastric acid secretion; Focal adhesion; cGMP-PKG signaling pathway; Calcium signaling pathway,MicroRNAs in cardiomyocyte hypertrophy; Endothelin Pathways; Focal Adhesion; Association Between Physico-Chemical Features and Toxicity Associated Pathways; Regulation of Actin Cytoskeleton,RHO GTPases activate PAKs; Smooth Muscle Contraction,19,High,1
Q9Y4E1-1,Isoform 4 of WASH complex subunit 2C OS=Homo sapiens OX=9606 GN=WASHC2C,0,113.481,22,19,86,2,1318,144.6,4.79,37973,2.56,19,1,regulation of biological process;transport,cytosol;endosome;membrane,protein binding,Pf15255,253725,,FAM21C; WASHC2C,10,Endocytosis,,,1,High,1
O75340,Programmed cell death protein 6 OS=Homo sapiens OX=9606 GN=PDCD6 PE=1 SV=1,0,113.435,60,11,130,11,191,21.9,5.4,64329,0,11,1,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;endosome;membrane;nucleus,catalytic activity;metal ion binding;protein binding,"Pf00036, Pf13405, Pf13499, Pf13833",10016,ENSG00000249915.7,PDCD6,5,,,,0,High,1
O94911-3,Isoform 3 of ATP-binding cassette sub-family A member 8 OS=Homo sapiens OX=9606 GN=ABCA8,0,113.425,16,21,124,19,1621,183.6,7.25,53579,10.51,19,3,transport,membrane,catalytic activity;nucleotide binding;transporter activity,"Pf00005, Pf03193, Pf12698, Pf12730, Pf13304",10351,ENSG00000141338.13,ABCA8,17,,,,0,High,1
O14579,Coatomer subunit epsilon OS=Homo sapiens OX=9606 GN=COPE PE=1 SV=3,0,113.387,37,11,98,11,308,34.5,5.12,55029,,11,,transport,cytoplasm;cytosol;Golgi;membrane,protein binding;structural molecule activity,Pf04733,11316,ENSG00000105669.13,COPE,19,,,COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport,11,High,1
Q96BM9,ADP-ribosylation factor-like protein 8A OS=Homo sapiens OX=9606 GN=ARL8A PE=1 SV=1,0,113.308,53,10,280,5,186,21.4,7.77,135379,9.89,9,1,cell division;regulation of biological process;response to stimulus;transport,cytoplasm;endosome;membrane;vacuole,catalytic activity;nucleotide binding;protein binding;signal transducer activity,"Pf00025, Pf00071, Pf00503, Pf04670, Pf08477, Pf09439",127829,ENSG00000143862.7,ARL8A,1,,,Neutrophil degranulation,3,High,1
O15067,Phosphoribosylformylglycinamidine synthase OS=Homo sapiens OX=9606 GN=PFAS PE=1 SV=4,0,113.209,20,17,101,17,1338,144.6,5.76,38822,1.73,17,1,metabolic process;response to stimulus,cytoplasm;cytosol,catalytic activity;metal ion binding;nucleotide binding,"Pf00586, Pf02769, Pf13507",5198,ENSG00000178921.13,PFAS,17,Purine metabolism; Metabolic pathways,,Purine ribonucleoside monophosphate biosynthesis,6,High,1
Q9H8M1,"Coenzyme Q-binding protein COQ10 homolog B, mitochondrial OS=Homo sapiens OX=9606 GN=COQ10B PE=2 SV=1",0,113.111,50,12,305,11,238,27.1,9.6,138186,11.09,12,3,metabolic process,membrane;mitochondrion,,Pf03364,80219,ENSG00000115520.8,COQ10B,2,,,Respiratory electron transport,4,High,1
P28070,Proteasome subunit beta type-4 OS=Homo sapiens OX=9606 GN=PSMB4 PE=1 SV=4,0,113.089,52,9,263,9,264,29.2,5.97,139384,,9,,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus;proteasome,catalytic activity;enzyme regulator activity;protein binding,Pf00227,5692,ENSG00000159377.10,PSMB4,1,Proteasome,Proteasome Degradation,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,150,High,1
Q9Y266,Nuclear migration protein nudC OS=Homo sapiens OX=9606 GN=NUDC PE=1 SV=1,0,113.086,41,14,196,14,331,38.2,5.38,84558,0,14,1,cell division;cell organization and biogenesis;cell proliferation;development;metabolic process,cytoplasm;cytoskeleton;cytosol;nucleus,protein binding,"Pf04969, Pf14050",10726,ENSG00000090273.13,NUDC,1,,,Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; Mitotic Telophase/Cytokinesis,17,High,1
Q9Y376,Calcium-binding protein 39 OS=Homo sapiens OX=9606 GN=CAB39 PE=1 SV=1,0,112.893,37,14,300,11,341,39.8,6.89,136919,,14,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;organelle lumen,catalytic activity;enzyme regulator activity;protein binding,Pf08569,51719,ENSG00000135932.10,CAB39,2,AMPK signaling pathway; mTOR signaling pathway,AMP-activated Protein Kinase (AMPK) Signaling; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Endochondral Ossification,Energy dependent regulation of mTOR by LKB1-AMPK; Neutrophil degranulation,11,High,1
Q14165,Malectin OS=Homo sapiens OX=9606 GN=MLEC PE=1 SV=1,0,112.892,50,12,227,12,292,32.2,5.41,90627,5.04,12,1,metabolic process;transport,endoplasmic reticulum;membrane,protein binding,Pf11721,9761,ENSG00000110917.7,MLEC,12,,,Neutrophil degranulation; N-glycan trimming in the ER and Calnexin/Calreticulin cycle,7,High,1
Q16543,Hsp90 co-chaperone Cdc37 OS=Homo sapiens OX=9606 GN=CDC37 PE=1 SV=1,0,112.766,36,13,262,13,378,44.4,5.25,116300,,13,,cell division;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol,catalytic activity;enzyme regulator activity;protein binding,"Pf03234, Pf08564, Pf08565",11140,ENSG00000105401.8,CDC37,19,PI3K-Akt signaling pathway,TNF alpha Signaling Pathway; Aryl Hydrocarbon Receptor; Aryl Hydrocarbon Receptor Pathway; Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,Downregulation of ERBB2 signaling; Constitutive Signaling by EGFRvIII; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants,17,High,1
P27105,Erythrocyte band 7 integral membrane protein OS=Homo sapiens OX=9606 GN=STOM PE=1 SV=3,0,112.428,48,9,329,9,288,31.7,7.88,156897,0,9,1,cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;mitochondrion,protein binding,Pf01145,2040,ENSG00000148175.12,STOM,9,,,Neutrophil degranulation; Stimuli-sensing channels,6,High,1
P62906,60S ribosomal protein L10a OS=Homo sapiens OX=9606 GN=RPL10A PE=1 SV=2,0,112.372,27,9,426,9,217,24.8,9.94,213002,,9,,cell organization and biogenesis;metabolic process;response to stimulus;transport,cytosol;membrane;nucleus;ribosome,protein binding;RNA binding;structural molecule activity,Pf00687,4736,ENSG00000198755.10,RPL10A,6,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
Q02790,Peptidyl-prolyl cis-trans isomerase FKBP4 OS=Homo sapiens OX=9606 GN=FKBP4 PE=1 SV=3,0,112.296,42,17,140,17,459,51.8,5.43,60360,,17,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;mitochondrion;nucleus,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00254, Pf00515, Pf07719, Pf13174, Pf13371, Pf13414, Pf13424, Pf13432, Pf14559",2288,ENSG00000004478.7,FKBP4,12,Estrogen signaling pathway,Androgen receptor signaling pathway,Attenuation phase; HSP90 chaperone cycle for steroid hormone receptors (SHR),8,High,1
P30876,DNA-directed RNA polymerase II subunit RPB2 OS=Homo sapiens OX=9606 GN=POLR2B PE=1 SV=1,0,112.247,22,22,107,22,1174,133.8,6.87,41473,1.8,22,3,metabolic process;regulation of biological process;response to stimulus,membrane;nucleus,catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding,"Pf00562, Pf04560, Pf04561, Pf04563, Pf04565, Pf04566, Pf04567",5431,ENSG00000047315.15,POLR2B,4,Metabolic pathways; Epstein-Barr virus infection; Purine metabolism; Pyrimidine metabolism; RNA polymerase; Huntington's disease,Eukaryotic Transcription Initiation,Signaling by FGFR2 IIIa TM; RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Formation of HIV-1 elongation complex containing HIV-1 Tat; MicroRNA (miRNA) biogenesis; Formation of the HIV-1 Early Elongation Complex; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; TP53 Regulates Transcription of DNA Repair Genes; Transcriptional regulation by small RNAs; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; RNA Polymerase II HIV Promoter Escape; Formation of HIV elongation complex in the absence of HIV Tat; Transcriptional regulation of pluripotent stem cells; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; Formation of TC-NER Pre-Incision Complex; Pausing and recovery of HIV elongation; RNA Polymerase II Promoter Escape; HIV elongation arrest and recovery; RNA Pol II CTD phosphorylation and interaction with CE; Viral Messenger RNA Synthesis; RNA Polymerase II Transcription Initiation; mRNA Capping; Dual incision in TC-NER; PIWI-interacting RNA (piRNA) biogenesis; Pausing and recovery of Tat-mediated HIV elongation; Formation of the Early Elongation Complex,75,High,1
Q96CV9,Optineurin OS=Homo sapiens OX=9606 GN=OPTN PE=1 SV=3,0,112.141,34,17,154,17,577,65.9,5.17,65048,,17,,cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;Golgi;membrane;nucleus;vacuole,metal ion binding;protein binding,Pf11577,10133,ENSG00000123240.16,OPTN,10,,,,0,High,1
Q14678,KN motif and ankyrin repeat domain-containing protein 1 OS=Homo sapiens OX=9606 GN=KANK1 PE=1 SV=3,0,112.09,18,16,142,14,1352,147.2,5.3,59641,0,16,1,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;membrane;nucleus,protein binding,"Pf00023, Pf05667, Pf10267, Pf12075, Pf12796, Pf13606, Pf13637, Pf13857",23189,ENSG00000107104.18,KANK1,9,,,,0,High,1
Q15257,Serine/threonine-protein phosphatase 2A activator OS=Homo sapiens OX=9606 GN=PTPA PE=1 SV=3,0,112.014,46,13,206,13,358,40.6,5.94,96026,0,13,1,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;nucleus,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding,Pf03095,5524,ENSG00000119383.19,PPP2R4; PTPA,9,Insulin resistance,Interleukin-11 Signaling Pathway; Constitutive Androstane Receptor Pathway; ATM Signaling Network in Development and Disease; Wnt Signaling Pathway and Pluripotency; Glycogen Metabolism,,6,High,1
Q13825,"Methylglutaconyl-CoA hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=AUH PE=1 SV=1",0,111.933,29,11,396,11,339,35.6,9.48,202480,0,11,2,metabolic process,mitochondrion;organelle lumen,catalytic activity;RNA binding,Pf00378,549,ENSG00000148090.11,AUH,9,"Metabolic pathways; Valine, leucine and isoleucine degradation",Amino Acid metabolism,Branched-chain amino acid catabolism,6,High,1
Q15599-2,Isoform 2 of Na(+)/H(+) exchange regulatory cofactor NHE-RF2 OS=Homo sapiens OX=9606 GN=SLC9A3R2,0,111.924,55,15,133,6,326,36.1,8.21,61101,3.04,14,1,cell organization and biogenesis,membrane;nucleus,protein binding;structural molecule activity,"Pf00595, Pf09007, Pf13180",9351,ENSG00000065054.13,SLC9A3R2,16,,,,0,High,1
Q3KQU3,MAP7 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=MAP7D1 PE=1 SV=1,0,111.889,23,14,118,14,841,92.8,10.11,56628,0,14,2,cell organization and biogenesis,cytoplasm;cytoskeleton;cytosol,structural molecule activity,,55700,ENSG00000116871.15,MAP7D1,1,,,,0,High,1
O75190-3,Isoform C of DnaJ homolog subfamily B member 6 OS=Homo sapiens OX=9606 GN=DNAJB6,0,111.814,52,11,123,2,325,35.7,6.9,55996,60.57,7,5,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process,cytosol;membrane;nucleus,DNA binding;enzyme regulator activity;protein binding,Pf00226,10049,,DNAJB6,7,,,,0,High,1
Q9NR19,"Acetyl-coenzyme A synthetase, cytoplasmic OS=Homo sapiens OX=9606 GN=ACSS2 PE=1 SV=1",0,111.789,30,16,162,16,701,78.5,6.46,69137,,16,,cell organization and biogenesis;metabolic process,cytoplasm;cytosol;organelle lumen,catalytic activity;nucleotide binding,"Pf00501, Pf13193",55902,ENSG00000131069.19,ACSS2,20,Metabolic pathways; Propanoate metabolism; Pyruvate metabolism; Glycolysis / Gluconeogenesis; Carbon metabolism,Fatty Acid Beta Oxidation; Fatty Acid Biosynthesis; Amino acid conjugation of benzoic acid,Transcriptional activation of mitochondrial biogenesis; Ethanol oxidation,15,High,1
Q6PCB0,von Willebrand factor A domain-containing protein 1 OS=Homo sapiens OX=9606 GN=VWA1 PE=1 SV=1,0,111.631,47,13,99,13,445,46.8,7.68,41223,,13,,cell organization and biogenesis;metabolic process;response to stimulus,extracellular;organelle lumen,protein binding,"Pf00041, Pf00092, Pf13519",64856,ENSG00000179403.11,VWA1,1,,,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs),4,High,1
Q9NVT9,Armadillo repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=ARMC1 PE=1 SV=1,0,111.629,47,11,176,11,282,31.3,5.74,82177,8.7,11,3,transport,cytoplasm;mitochondrion;nucleus,metal ion binding;protein binding,Pf00514,55156,ENSG00000104442.9,ARMC1,8,,,,0,High,1
Q96PD5,N-acetylmuramoyl-L-alanine amidase OS=Homo sapiens OX=9606 GN=PGLYRP2 PE=1 SV=1,0,111.604,23,9,179,9,576,62.2,7.55,80111,,9,,defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,catalytic activity;metal ion binding;receptor activity;signal transducer activity,Pf01510,114770,ENSG00000161031.12,PGLYRP2,19,,,Antimicrobial peptides,3,High,1
Q14767,Latent-transforming growth factor beta-binding protein 2 OS=Homo sapiens OX=9606 GN=LTBP2 PE=1 SV=3,0,111.603,11,13,124,13,1821,194.9,5.19,59723,0,13,1,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cell surface;extracellular;membrane,metal ion binding;protein binding,"Pf00683, Pf06247, Pf07645, Pf12662",4053,ENSG00000119681.11,LTBP2,14,,Hypothesized Pathways in Pathogenesis of Cardiovascular Disease,Molecules associated with elastic fibres,4,High,1
P62241,40S ribosomal protein S8 OS=Homo sapiens OX=9606 GN=RPS8 PE=1 SV=2,0,111.477,38,10,298,10,208,24.2,10.32,158787,2.02,10,1,cell organization and biogenesis;metabolic process;transport,cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;ribosome,protein binding;RNA binding;structural molecule activity,Pf01201,6202,ENSG00000142937.11,RPS8,1,Ribosome,Cytoplasmic Ribosomal Proteins,"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane",38,High,1
Q9NZJ7,Mitochondrial carrier homolog 1 OS=Homo sapiens OX=9606 GN=MTCH1 PE=1 SV=1,0,111.391,25,10,392,10,389,41.5,9.32,165768,2.08,10,1,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;transport,membrane;mitochondrion,protein binding,Pf00153,23787,ENSG00000137409.19,MTCH1,6,,,,0,High,1
Q9H1E3,Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 OS=Homo sapiens OX=9606 GN=NUCKS1 PE=1 SV=1,0,111.325,39,12,131,12,243,27.3,5.08,67335,10.74,10,2,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;nucleus,DNA binding;protein binding;RNA binding,,64710,ENSG00000069275.12,NUCKS1,1,,,,0,High,1
Q02880,DNA topoisomerase 2-beta OS=Homo sapiens OX=9606 GN=TOP2B PE=1 SV=3,0,111.109,17,23,81,23,1626,183.2,8,34903,0,23,2,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding,"Pf00204, Pf00521, Pf01751, Pf02518, Pf08070, Pf13589",7155,ENSG00000077097.15,TOP2B,3,Platinum drug resistance,,SUMOylation of DNA replication proteins,6,High,1
O95139,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 OS=Homo sapiens OX=9606 GN=NDUFB6 PE=1 SV=3,0,110.88,66,11,929,11,128,15.5,9.63,430992,7.59,10,2,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion,catalytic activity,Pf09782,4712,ENSG00000165264.10,NDUFB6,9,Non-alcoholic fatty liver disease (NAFLD); Alzheimer's disease; Huntington's disease; Metabolic pathways; Oxidative phosphorylation; Parkinson's disease,Electron Transport Chain; Oxidative phosphorylation,Complex I biogenesis,13,High,1
Q9Y5X1,Sorting nexin-9 OS=Homo sapiens OX=9606 GN=SNX9 PE=1 SV=1,0,110.811,33,15,105,15,595,66.6,5.58,49670,0,15,1,cell division;cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytosol;Golgi;membrane,protein binding,"Pf00018, Pf00787, Pf07653, Pf10456, Pf14604",51429,ENSG00000130340.15,SNX9,6,,,Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis,6,High,1
Q9Y5Z4,Heme-binding protein 2 OS=Homo sapiens OX=9606 GN=HEBP2 PE=1 SV=1,0,110.807,61,10,300,10,205,22.9,4.63,146947,3.71,10,3,cell organization and biogenesis;regulation of biological process;transport,cytoplasm;extracellular;mitochondrion;organelle lumen,protein binding,Pf04832,23593,ENSG00000051620.10,HEBP2,6,,,Neutrophil degranulation,3,High,1
O76003,Glutaredoxin-3 OS=Homo sapiens OX=9606 GN=GLRX3 PE=1 SV=2,0,110.72,46,13,222,13,335,37.4,5.39,98887,,13,,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus;spliceosomal complex,catalytic activity;metal ion binding;protein binding;RNA binding,"Pf00085, Pf00462, Pf02114, Pf02966, Pf04908, Pf13098, Pf13905",10539,ENSG00000108010.11,GLRX3,10,,,Iron uptake and transport,2,High,1
Q96JJ7,Protein disulfide-isomerase TMX3 OS=Homo sapiens OX=9606 GN=TMX3 PE=1 SV=2,0,110.667,33,15,132,15,454,51.8,4.91,58800,0,15,2,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;endoplasmic reticulum;membrane,catalytic activity;metal ion binding;protein binding,"Pf00085, Pf01216, Pf13098, Pf13848, Pf13899",54495,ENSG00000166479.9,TMX3,18,,,Platelet degranulation,4,High,1
P48163,NADP-dependent malic enzyme OS=Homo sapiens OX=9606 GN=ME1 PE=1 SV=1,0,110.595,28,15,199,14,572,64.1,6.13,93190,0,15,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;mitochondrion,catalytic activity;metal ion binding;nucleotide binding,"Pf00390, Pf03949",4199,ENSG00000065833.8,ME1,6,PPAR signaling pathway; Metabolic pathways; Pyruvate metabolism; Carbon metabolism,NRF2 pathway; PPAR signaling pathway,PPARA activates gene expression,10,High,1
Q86TI2,Dipeptidyl peptidase 9 OS=Homo sapiens OX=9606 GN=DPP9 PE=1 SV=3,0,110.535,29,17,121,17,863,98.2,6.46,45535,9.08,17,2,metabolic process,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,"Pf00326, Pf00930, Pf02129, Pf12695, Pf12697",91039,ENSG00000142002.16,DPP9,19,,Lung fibrosis,,1,High,1
Q5GLZ8,Probable E3 ubiquitin-protein ligase HERC4 OS=Homo sapiens OX=9606 GN=HERC4 PE=1 SV=1,0,110.464,26,21,80,21,1057,118.5,6.19,30755,,21,,cell differentiation;metabolic process,cytoplasm;cytosol,catalytic activity,"Pf00415, Pf00632, Pf13540",26091,ENSG00000148634.15,HERC4,10,Ubiquitin mediated proteolysis,,Antigen processing: Ubiquitination & Proteasome degradation,5,High,1
O76031,"ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial OS=Homo sapiens OX=9606 GN=CLPX PE=1 SV=2",0,110.195,42,20,139,20,633,69.2,7.58,52025,0,20,1,metabolic process;regulation of biological process,cytosol;membrane;mitochondrion;organelle lumen,catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding,"Pf00004, Pf01078, Pf05729, Pf07724, Pf07726, Pf07728, Pf10431, Pf13401, Pf14532",10845,ENSG00000166855.9,CLPX,15,,,,0,High,1
P20700,Lamin-B1 OS=Homo sapiens OX=9606 GN=LMNB1 PE=1 SV=2,0,109.928,45,18,134,17,586,66.4,5.16,63964,0,18,1,regulation of biological process;response to stimulus,membrane;nucleus,catalytic activity;motor activity;protein binding;structural molecule activity,"Pf00038, Pf00932, Pf01576, Pf07888, Pf09726, Pf09731, Pf10186, Pf12128",4001,ENSG00000113368.11,LMNB1,5,Apoptosis,Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation,Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Breakdown of the nuclear lamina; Initiation of Nuclear Envelope Reformation; Clearance of Nuclear Envelope Membranes from Chromatin; Meiotic synapsis; Depolymerisation of the Nuclear Lamina; Formation of Senescence-Associated Heterochromatin Foci (SAHF); Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Interleukin-12 family signaling,34,High,1
Q92522,Histone H1x OS=Homo sapiens OX=9606 GN=H1FX PE=1 SV=1,0,109.881,32,11,231,11,213,22.5,10.76,113273,,11,,cell organization and biogenesis,chromosome;nucleus,DNA binding;protein binding;RNA binding,Pf00538,8971,ENSG00000184897.5,H1FX,3,,,,0,High,1
Q15717,ELAV-like protein 1 OS=Homo sapiens OX=9606 GN=ELAVL1 PE=1 SV=2,0,109.82,48,11,187,11,326,36.1,9.17,94692,0,11,1,development;metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;nucleus,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",1994,ENSG00000066044.14,ELAVL1,19,AMPK signaling pathway,AMP-activated Protein Kinase (AMPK) Signaling; Endoderm Differentiation; Preimplantation Embryo; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,HuR (ELAVL1) binds and stabilizes mRNA; mRNA Splicing - Major Pathway,11,High,1
Q93050-1,Isoform 2 of V-type proton ATPase 116 kDa subunit a isoform 1 OS=Homo sapiens OX=9606 GN=ATP6V0A1,0,109.812,24,18,144,17,831,95.7,6.65,56328,0,18,1,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;Golgi;membrane,catalytic activity;protein binding;transporter activity,Pf01496,535,ENSG00000033627.16,ATP6V0A1,17,,,,0,High,1
P56199,Integrin alpha-1 OS=Homo sapiens OX=9606 GN=ITGA1 PE=1 SV=2,0,109.796,23,20,126,20,1179,130.8,6.29,54507,0,19,1,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cell surface;membrane,metal ion binding;protein binding,"Pf00092, Pf01839, Pf08441, Pf13517, Pf13519, Pf14312",3672,ENSG00000213949.8,ITGA1,5,Regulation of actin cytoskeleton; PI3K-Akt signaling pathway; Hematopoietic cell lineage; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Hypertrophic cardiomyopathy (HCM); ECM-receptor interaction; Focal adhesion; Dilated cardiomyopathy,Integrin-mediated Cell Adhesion; Arrhythmogenic Right Ventricular Cardiomyopathy; miRNA targets in ECM and membrane receptors; Signaling of Hepatocyte Growth Factor Receptor; NOTCH1 regulation of human endothelial cell calcification; Regulation of Actin Cytoskeleton,CHL1 interactions; Other semaphorin interactions; Integrin cell surface interactions; Smooth Muscle Contraction; Laminin interactions; Platelet Adhesion to exposed collagen,27,High,1
Q7L2H7,Eukaryotic translation initiation factor 3 subunit M OS=Homo sapiens OX=9606 GN=EIF3M PE=1 SV=1,0,109.79,32,10,182,10,374,42.5,5.63,84968,,10,,metabolic process,cytoplasm;cytosol,protein binding;RNA binding,Pf01399,10480,ENSG00000149100.12,EIF3M,11,,,"Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Ribosomal scanning and start codon recognition",11,High,1
P82930,"28S ribosomal protein S34, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS34 PE=1 SV=2",0,109.777,57,11,241,11,218,25.6,9.98,126893,,11,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,structural molecule activity,,65993,ENSG00000074071.14,MRPS34,16,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
P29622,Kallistatin OS=Homo sapiens OX=9606 GN=SERPINA4 PE=1 SV=3,0,109.636,34,12,148,12,427,48.5,7.75,64019,,12,,regulation of biological process;transport,extracellular;organelle lumen,enzyme regulator activity,Pf00079,5267,ENSG00000100665.11,SERPINA4,14,,,Platelet degranulation,4,High,1
O95167,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 OS=Homo sapiens OX=9606 GN=NDUFA3 PE=1 SV=1,0,109.521,50,8,458,8,84,9.3,8.46,207486,3.99,8,2,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion,catalytic activity,Pf14987,4696,ENSG00000273642.1; ENSG00000276766.1; ENSG00000275605.1; ENSG00000276220.1; ENSG00000276061.4; ENSG00000170906.15; ENSG00000278365.1; ENSG00000275724.1; ENSG00000277722.1; ENSG00000274359.1,NDUFA3,19; CHR_HSCHR19LRC_LRC_J_CTG3_1; CHR_HSCHR19LRC_LRC_I_CTG3_1; CHR_HSCHR19LRC_PGF1_CTG3_1; CHR_HSCHR19LRC_COX2_CTG3_1; CHR_HSCHR19_4_CTG3_1; CHR_HSCHR19LRC_LRC_S_CTG3_1; CHR_HSCHR19LRC_LRC_T_CTG3_1; CHR_HSCHR19LRC_PGF2_CTG3_1; CHR_HSCHR19LRC_COX1_CTG3_1,Non-alcoholic fatty liver disease (NAFLD); Parkinson's disease; Oxidative phosphorylation; Huntington's disease; Metabolic pathways; Alzheimer's disease,Electron Transport Chain; Oxidative phosphorylation,Complex I biogenesis,13,High,1
Q9Y2Z0,Protein SGT1 homolog OS=Homo sapiens OX=9606 GN=SUGT1 PE=1 SV=3,0,109.459,47,16,93,16,365,41,5.16,42950,,16,,regulation of biological process,chromosome;cytoplasm;cytosol;nucleus,protein binding,"Pf00515, Pf04969, Pf05002, Pf13414, Pf13431, Pf13432, Pf14559",10910,ENSG00000165416.14,SUGT1,13,NOD-like receptor signaling pathway,Nucleotide-binding Oligomerization Domain (NOD) pathway,The NLRP3 inflammasome,7,High,1
Q71UI9,Histone H2A.V OS=Homo sapiens OX=9606 GN=H2AFV PE=1 SV=3,0,109.309,54,13,1818,10,128,13.5,10.58,991158,0,13,1,regulation of biological process,chromosome;nucleus,DNA binding;protein binding,Pf00125,94239,ENSG00000105968.18,H2AFV,7,Alcoholism; Systemic lupus erythematosus,,SIRT1 negatively regulates rRNA expression; RMTs methylate histone arginines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; NoRC negatively regulates rRNA expression; Meiotic synapsis; Transcriptional regulation by small RNAs; Meiotic recombination; PRC2 methylates histones and DNA; Formation of the beta-catenin:TCF transactivating complex; DNA methylation; Packaging Of Telomere Ends; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RNA Polymerase I Chain Elongation; Deposition of new CENPA-containing nucleosomes at the centromere; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); B-WICH complex positively regulates rRNA expression; Oxidative Stress Induced Senescence; RNA Polymerase I Promoter Opening,57,High,1
O95793,Double-stranded RNA-binding protein Staufen homolog 1 OS=Homo sapiens OX=9606 GN=STAU1 PE=1 SV=2,0,109.271,42,18,122,17,577,63.1,9.44,49605,,18,,regulation of biological process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;membrane,protein binding;RNA binding,"Pf00035, Pf14709",6780,ENSG00000124214.19,STAU1,20,,,,0,High,1
P22307,Non-specific lipid-transfer protein OS=Homo sapiens OX=9606 GN=SCP2 PE=1 SV=2,0,109.27,39,17,301,17,547,59,6.89,137198,,17,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;membrane;mitochondrion;organelle lumen,catalytic activity;protein binding;transporter activity,"Pf00108, Pf00109, Pf02036, Pf02801, Pf02803, Pf08545, Pf14864",6342,ENSG00000116171.17,SCP2,1,Primary bile acid biosynthesis; PPAR signaling pathway; Metabolic pathways; Peroxisome,PPAR Alpha Pathway; Mitochondrial LC-Fatty Acid Beta-Oxidation; PPAR signaling pathway; DNA Damage Response (only ATM dependent),Beta-oxidation of pristanoyl-CoA; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; alpha-linolenic acid (ALA) metabolism,19,High,1
P48728,"Aminomethyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=AMT PE=1 SV=1",0,108.945,42,14,250,14,403,43.9,8.57,111435,11.21,12,4,metabolic process,mitochondrion;organelle lumen,catalytic activity,"Pf01571, Pf08669",275,ENSG00000145020.15,AMT,3,"Glycine, serine and threonine metabolism; One carbon pool by folate; Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism",One Carbon Metabolism; Trans-sulfuration and one carbon metabolism,Glycine degradation,11,High,1
Q9H061,Transmembrane protein 126A OS=Homo sapiens OX=9606 GN=TMEM126A PE=1 SV=1,0,108.78,50,12,225,12,195,21.5,9.26,114139,0,12,1,,membrane;mitochondrion,,Pf07114,84233,ENSG00000171202.6,TMEM126A,11,,,,0,High,1
P05026,Sodium/potassium-transporting ATPase subunit beta-1 OS=Homo sapiens OX=9606 GN=ATP1B1 PE=1 SV=1,0,108.658,36,10,477,10,303,35,8.53,242341,11.46,8,2,cell communication;cell organization and biogenesis;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,membrane,catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding;transporter activity,Pf00287,481,ENSG00000143153.12,ATP1B1,1,Adrenergic signaling in cardiomyocytes; Proximal tubule bicarbonate reclamation; cAMP signaling pathway; cGMP-PKG signaling pathway; Gastric acid secretion; Pancreatic secretion; Insulin secretion; Protein digestion and absorption; Cardiac muscle contraction; Bile secretion; Carbohydrate digestion and absorption; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Endocrine and other factor-regulated calcium reabsorption; Mineral absorption; Salivary secretion; Aldosterone-regulated sodium reabsorption,Calcium Regulation in the Cardiac Cell,Ion homeostasis; Basigin interactions; Ion transport by P-type ATPases,27,High,1
Q9NUQ8,ATP-binding cassette sub-family F member 3 OS=Homo sapiens OX=9606 GN=ABCF3 PE=1 SV=2,0,108.651,38,17,98,17,709,79.7,6.34,44034,,17,,defense response;response to stimulus,membrane,catalytic activity;nucleotide binding;protein binding,"Pf00005, Pf02463, Pf12848, Pf13304",55324,ENSG00000161204.11,ABCF3,3,,,,0,High,1
P54725,UV excision repair protein RAD23 homolog A OS=Homo sapiens OX=9606 GN=RAD23A PE=1 SV=1,0,108.546,59,14,150,11,363,39.6,4.58,66678,0,14,1,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus;proteasome,DNA binding;protein binding,"Pf00240, Pf00627, Pf09280, Pf11976",5886,ENSG00000179262.9,RAD23A,19,Nucleotide excision repair; Protein processing in endoplasmic reticulum,,Josephin domain DUBs; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER,11,High,1
P37837,Transaldolase OS=Homo sapiens OX=9606 GN=TALDO1 PE=1 SV=2,0,108.371,32,14,388,14,337,37.5,6.81,169352,0,14,2,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,Pf00923,6888,ENSG00000177156.10,TALDO1,11,Pentose phosphate pathway; Biosynthesis of amino acids; Metabolic pathways; Carbon metabolism,Pentose Phosphate Pathway; Cori Cycle,"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Insulin effects increased synthesis of Xylulose-5-Phosphate; TALDO1 deficiency: failed conversion of  Fru(6)P, E4P to SH7P, GA3P; Interleukin-12 family signaling; TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P; Pentose phosphate pathway (hexose monophosphate shunt)",22,High,1
P49590,"Probable histidine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=HARS2 PE=1 SV=1",0,108.327,32,16,209,10,506,56.9,8.24,105209,,16,,cell organization and biogenesis;metabolic process,cytoplasm;mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00587, Pf03129, Pf12745, Pf13393",23438,ENSG00000112855.14,HARS2,5,Aminoacyl-tRNA biosynthesis,,Mitochondrial tRNA aminoacylation,5,High,1
Q14141,Septin-6 OS=Homo sapiens OX=9606 GN=SEPTIN6 PE=1 SV=4,0,108.256,35,13,244,4,434,49.7,6.67,116582,0,13,2,cell differentiation;cell division,chromosome;cytoplasm;cytoskeleton,nucleotide binding;protein binding,Pf00735,23157,ENSG00000125354.22,SEPT6,X,Bacterial invasion of epithelial cells,,,1,High,1
Q9UBV2,Protein sel-1 homolog 1 OS=Homo sapiens OX=9606 GN=SEL1L PE=1 SV=3,0,108.19,34,16,58,16,794,88.7,5.39,21708,,16,,metabolic process;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;membrane,protein binding,"Pf00040, Pf08238",6400,ENSG00000071537.13,SEL1L,14,Protein processing in endoplasmic reticulum,,Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; Pre-NOTCH Processing in Golgi; ER Quality Control Compartment (ERQC); ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Hedgehog ligand biogenesis,22,High,1
P16083,Ribosyldihydronicotinamide dehydrogenase [quinone] OS=Homo sapiens OX=9606 GN=NQO2 PE=1 SV=5,0,108.136,45,10,171,10,231,25.9,6.29,71296,0,10,1,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf02525, Pf03358",4835,ENSG00000124588.19,NQO2,6,,Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling,Phase I - Functionalization of compounds,4,High,1
P30533,Alpha-2-macroglobulin receptor-associated protein OS=Homo sapiens OX=9606 GN=LRPAP1 PE=1 SV=1,0,108.036,38,13,221,13,357,41.4,8.78,98870,,13,,regulation of biological process;transport,cell surface;cytoplasm;endoplasmic reticulum;endosome;extracellular;Golgi;membrane;organelle lumen,protein binding,"Pf06400, Pf06401",4043,ENSG00000163956.10,LRPAP1,4,,,,0,High,1
Q15599-3,Isoform 3 of Na(+)/H(+) exchange regulatory cofactor NHE-RF2 OS=Homo sapiens OX=9606 GN=SLC9A3R2,0,108.008,50,12,135,3,226,24.7,9.36,62709,8.79,11,1,cell organization and biogenesis,membrane;nucleus,protein binding;structural molecule activity,"Pf00595, Pf09007, Pf13180",9351,ENSG00000065054.13,SLC9A3R2,16,,,,0,High,1
Q9Y676,"28S ribosomal protein S18b, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS18B PE=1 SV=1",0,107.992,41,8,113,8,258,29.4,9.38,54642,,8,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,protein binding;structural molecule activity,Pf01084,28973,ENSG00000227420.8; ENSG00000229861.8; ENSG00000233813.8; ENSG00000223775.8; ENSG00000226111.8; ENSG00000204568.11; ENSG00000203624.10,MRPS18B,6; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_QBL_CTG1,Viral carcinogenesis,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
P50579-2,Isoform 2 of Methionine aminopeptidase 2 OS=Homo sapiens OX=9606 GN=METAP2,0,107.915,33,12,97,1,455,50.5,5.35,38482,11.19,11,2,metabolic process;regulation of biological process,cytoplasm;cytosol;membrane,catalytic activity;metal ion binding;RNA binding,Pf00557,10988,ENSG00000111142.13,METAP2,12,,,,0,High,1
Q15172,Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R5A PE=1 SV=1,0,107.79,37,18,139,17,486,56.2,6.71,62611,5.17,17,2,regulation of biological process;response to stimulus,chromosome;cytoplasm;cytosol;membrane;nucleus,enzyme regulator activity;protein binding,Pf01603,5525,ENSG00000066027.11,PPP2R5A,1,Oocyte meiosis; Dopaminergic synapse; AMPK signaling pathway; Sphingolipid signaling pathway; mRNA surveillance pathway; Adrenergic signaling in cardiomyocytes; PI3K-Akt signaling pathway,Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Glycogen Metabolism,"Beta-catenin phosphorylation cascade; AXIN missense mutants destabilize the destruction complex; Negative regulation of MAPK pathway; APC truncation mutants have impaired AXIN binding; CTLA4 inhibitory signaling; Platelet sensitization by LDL; Separation of Sister Chromatids; Interleukin-20 family signaling; S37 mutants of beta-catenin aren't phosphorylated; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; S33 mutants of beta-catenin aren't phosphorylated; Disassembly of the destruction complex and recruitment of AXIN to the membrane; S45 mutants of beta-catenin aren't phosphorylated; Misspliced GSK3beta mutants stabilize beta-catenin; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Resolution of Sister Chromatid Cohesion; T41 mutants of beta-catenin aren't phosphorylated; RHO GTPases Activate Formins; RAF activation; Truncations of AMER1 destabilize the destruction complex",64,High,1
Q92629-2,Isoform 2 of Delta-sarcoglycan OS=Homo sapiens OX=9606 GN=SGCD,0,107.71,55,15,520,15,290,32.2,9.11,250396,37.8,12,4,cell organization and biogenesis,cytoplasm;cytoskeleton;membrane,,Pf04790,6444,ENSG00000170624.13,SGCD,5,,Arrhythmogenic Right Ventricular Cardiomyopathy,,1,High,1
Q15417,Calponin-3 OS=Homo sapiens OX=9606 GN=CNN3 PE=1 SV=1,0,107.614,57,14,134,12,329,36.4,6.05,47171,2.85,13,3,cell differentiation;cell organization and biogenesis;regulation of biological process,cytoskeleton;cytosol,protein binding,"Pf00307, Pf00402",1266,ENSG00000117519.15,CNN3,1,,,,0,High,1
O00217,"NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS8 PE=1 SV=1",0,107.574,33,9,860,9,210,23.7,6.34,406088,113.07,8,2,cell organization and biogenesis;metabolic process;response to stimulus;transport,membrane;mitochondrion;organelle lumen,catalytic activity;metal ion binding,"Pf00037, Pf12837, Pf12838, Pf13183, Pf13187, Pf13237, Pf13459, Pf13484, Pf13534, Pf14697",4728,ENSG00000110717.12,NDUFS8,11,Alzheimer's disease; Non-alcoholic fatty liver disease (NAFLD); Huntington's disease; Metabolic pathways; Oxidative phosphorylation; Parkinson's disease,Electron Transport Chain; Oxidative phosphorylation,Complex I biogenesis,13,High,1
Q15067,Peroxisomal acyl-coenzyme A oxidase 1 OS=Homo sapiens OX=9606 GN=ACOX1 PE=1 SV=3,0,107.444,34,15,90,1,660,74.4,8.16,37376,0,15,2,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;membrane;mitochondrion;nucleus;organelle lumen,catalytic activity;nucleotide binding;protein binding,"Pf01756, Pf02770, Pf14749",51,ENSG00000161533.11,ACOX1,17,Biosynthesis of unsaturated fatty acids; alpha-Linolenic acid metabolism; Peroxisome; Metabolic pathways; Fatty acid degradation; cAMP signaling pathway; PPAR signaling pathway; Fatty acid metabolism,Estrogen Receptor Pathway; PPAR signaling pathway,PPARA activates gene expression,14,High,1
Q9Y316,Protein MEMO1 OS=Homo sapiens OX=9606 GN=MEMO1 PE=1 SV=1,0,107.426,54,10,123,10,297,33.7,7.14,57127,1.94,10,1,regulation of biological process,cytosol;nucleus,protein binding,Pf01875,51072,ENSG00000162959.13,MEMO1,2,,,ERBB2 Regulates Cell Motility,4,High,1
Q5JTV8-3,Isoform 3 of Torsin-1A-interacting protein 1 OS=Homo sapiens OX=9606 GN=TOR1AIP1,0,107.044,38,16,120,15,584,66.3,8.18,49986,17.69,15,1,cell organization and biogenesis;regulation of biological process,membrane;nucleus,enzyme regulator activity;protein binding,Pf05609,26092,ENSG00000143337.18,TOR1AIP1,1,,,,0,High,1
Q14139,Ubiquitin conjugation factor E4 A OS=Homo sapiens OX=9606 GN=UBE4A PE=1 SV=2,0,107.034,24,17,70,17,1066,122.5,5.24,30774,,17,,metabolic process,cytoplasm;nucleus,catalytic activity;protein binding,"Pf04564, Pf10408",9354,ENSG00000110344.9,UBE4A,11,Ubiquitin mediated proteolysis,,Antigen processing: Ubiquitination & Proteasome degradation,5,High,1
Q86YB7,"Enoyl-CoA hydratase domain-containing protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=ECHDC2 PE=1 SV=2",0,107.029,41,11,137,11,292,31.1,8.72,63652,,11,,metabolic process,mitochondrion,catalytic activity,Pf00378,55268,ENSG00000121310.16,ECHDC2,1,,Fatty Acid Biosynthesis,,1,High,1
Q9Y666,Solute carrier family 12 member 7 OS=Homo sapiens OX=9606 GN=SLC12A7 PE=1 SV=3,0,106.937,23,17,129,16,1083,119,6.71,49087,,17,,cell communication;cellular homeostasis;transport,membrane,catalytic activity;protein binding;transporter activity,"Pf00324, Pf12474, Pf13520",10723,ENSG00000113504.20,SLC12A7,5,Collecting duct acid secretion,,Cation-coupled Chloride cotransporters,5,High,1
P16144,Integrin beta-4 OS=Homo sapiens OX=9606 GN=ITGB4 PE=1 SV=5,0,106.78,16,21,70,21,1822,202,6.09,28992,,21,,cell communication;cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cell surface;membrane;nucleus,protein binding;receptor activity,"Pf00041, Pf00362, Pf03160, Pf07965, Pf07974",3691,ENSG00000132470.13,ITGB4,17,ECM-receptor interaction; Dilated cardiomyopathy; Hypertrophic cardiomyopathy (HCM); Regulation of actin cytoskeleton; Arrhythmogenic right ventricular cardiomyopathy (ARVC); PI3K-Akt signaling pathway; Focal adhesion,Integrin-mediated Cell Adhesion; Arrhythmogenic Right Ventricular Cardiomyopathy; Alpha 6 Beta 4 signaling pathway; Primary Focal Segmental Glomerulosclerosis FSGS; Focal Adhesion; TGF-beta Signaling Pathway; Regulation of Apoptosis by Parathyroid Hormone-related Protein; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,Laminin interactions; Assembly of collagen fibrils and other multimeric structures; Type I hemidesmosome assembly; Syndecan interactions,24,High,1
Q09028,Histone-binding protein RBBP4 OS=Homo sapiens OX=9606 GN=RBBP4 PE=1 SV=3,0,106.681,43,12,139,7,425,47.6,4.89,69012,0,12,2,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytosol;nucleus,catalytic activity;DNA binding;protein binding,"Pf00400, Pf12265",5928,ENSG00000162521.18,RBBP4,1,,Retinoblastoma (RB) in Cancer; Interactome of polycomb repressive complex 2 (PRC2),Regulation of TP53 Activity through Acetylation; Polo-like kinase mediated events; PKMTs methylate histone lysines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Cyclin A:Cdk2-associated events at S phase entry; Deposition of new CENPA-containing nucleosomes at the centromere; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; Cyclin E associated events during G1/S transition ; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; PRC2 methylates histones and DNA; Activation of E2F1 target genes at G1/S; HDACs deacetylate histones; Transcription of E2F targets under negative control by DREAM complex; Oxidative Stress Induced Senescence; RNA Polymerase I Transcription Initiation,50,High,1
Q9ULV4,Coronin-1C OS=Homo sapiens OX=9606 GN=CORO1C PE=1 SV=1,0,106.657,20,13,217,12,474,53.2,7.08,99737,,13,,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;membrane,protein binding,"Pf00400, Pf08953, Pf08954",23603,ENSG00000110880.10,CORO1C,12,,,,0,High,1
P27348,14-3-3 protein theta OS=Homo sapiens OX=9606 GN=YWHAQ PE=1 SV=1,0,106.343,41,11,827,7,245,27.7,4.78,429087,11.69,10,3,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;mitochondrion,protein binding,Pf00244,10971,ENSG00000134308.13,YWHAQ,2,Epstein-Barr virus infection; Oocyte meiosis; Pathogenic Escherichia coli infection; Cell cycle; Hippo signaling pathway; Hepatitis B; Viral carcinogenesis; PI3K-Akt signaling pathway,Cell Cycle; Pathogenic Escherichia coli infection; Primary Focal Segmental Glomerulosclerosis FSGS; IL-3 Signaling Pathway; Myometrial Relaxation and Contraction Pathways; Calcium Regulation in the Cardiac Cell; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,Translocation of GLUT4 to the plasma membrane; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; TP53 Regulates Metabolic Genes; Activation of BAD and translocation to mitochondria ; RHO GTPases activate PKNs,37,High,1
Q96I59,"Probable asparagine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=NARS2 PE=1 SV=3",0,106.333,38,13,128,13,477,54.1,7.24,60673,,13,,metabolic process,cytoplasm;cytosol;mitochondrion;organelle lumen,catalytic activity;nucleotide binding,"Pf00152, Pf01336",79731,ENSG00000137513.9,NARS2,11,Aminoacyl-tRNA biosynthesis,Ectoderm Differentiation,Mitochondrial tRNA aminoacylation,6,High,1
Q92696,Geranylgeranyl transferase type-2 subunit alpha OS=Homo sapiens OX=9606 GN=RABGGTA PE=1 SV=2,0,106.28,32,17,142,17,567,65,5.67,66260,,17,,cell organization and biogenesis;metabolic process;regulation of biological process,cytosol;membrane,catalytic activity;metal ion binding;protein binding,"Pf01239, Pf07711, Pf12799, Pf13855, Pf14580",5875,ENSG00000100949.14,RABGGTA,14,,,TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; RAB geranylgeranylation,9,High,1
Q9ULT8,E3 ubiquitin-protein ligase HECTD1 OS=Homo sapiens OX=9606 GN=HECTD1 PE=1 SV=3,0,106.188,12,23,98,23,2610,289.2,5.35,38945,,23,,metabolic process,cytoplasm,catalytic activity;metal ion binding;protein binding,"Pf00023, Pf00632, Pf00754, Pf06701, Pf07738, Pf12796, Pf13606, Pf13637, Pf13857",25831,,HECTD1,14,,,Antigen processing: Ubiquitination & Proteasome degradation,4,High,1
Q5JWF2,Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas OS=Homo sapiens OX=9606 GN=GNAS PE=1 SV=2,0,106.173,18,15,326,1,1037,111,5.03,152045,,15,,metabolic process;regulation of biological process;response to stimulus,cytosol;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,"Pf00025, Pf00503, Pf08477",2778,ENSG00000087460.24,GNAS,20,,Human Thyroid Stimulating Hormone (TSH) signaling pathway; Endothelin Pathways; Corticotropin-releasing hormone signaling pathway; Common Pathways Underlying Drug Addiction; Myometrial Relaxation and Contraction Pathways; G Protein Signaling Pathways; Calcium Regulation in the Cardiac Cell; Estrogen signaling pathway; Serotonin Receptor 4/6/7 and NR3C Signaling,G alpha (z) signalling events; Prostacyclin signalling through prostacyclin receptor; PKA activation in glucagon signalling; G alpha (s) signalling events; Glucagon-type ligand receptors; G alpha (i) signalling events; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Hedgehog 'off' state; Vasopressin regulates renal water homeostasis via Aquaporins,32,High,1
Q7L5N1,COP9 signalosome complex subunit 6 OS=Homo sapiens OX=9606 GN=COPS6 PE=1 SV=1,0,106.115,42,11,173,11,327,36.1,5.73,77155,1.65,11,1,cell organization and biogenesis;metabolic process;response to stimulus,cytoplasm;cytosol;nucleus,protein binding,"Pf01398, Pf13012",10980,ENSG00000168090.9,COPS6,7,,Nucleotide-binding Oligomerization Domain (NOD) pathway,Cargo recognition for clathrin-mediated endocytosis; DNA Damage Recognition in GG-NER; Formation of TC-NER Pre-Incision Complex; Neddylation,14,High,1
Q32MK0-4,Isoform 2 of Myosin light chain kinase 3 OS=Homo sapiens OX=9606 GN=MYLK3,0,106.027,37,12,124,1,478,52.7,6.43,57788,56.7,8,7,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol,catalytic activity;nucleotide binding,"Pf00069, Pf07714",91807,ENSG00000140795.12,MYLK3,16,,MicroRNAs in cardiomyocyte hypertrophy; Cardiac Progenitor Differentiation,,2,High,1
P0DMN0,Sulfotransferase 1A4 OS=Homo sapiens OX=9606 GN=SULT1A4 PE=1 SV=1,0,106.027,65,15,131,8,295,34.2,6.01,57347,0,15,1,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,catalytic activity;protein binding,"Pf00685, Pf13469",445329; 6818; 100526830; 105369243,ENSG00000213648.10; ENSG00000261052.5,SULT1A4; LOC101929857; LOC101060714; SULT1A3; SLX1A-SULT1A3; LOC105369243,16,Chemical carcinogenesis,Sulfation Biotransformation Reaction; Metapathway biotransformation,Cytosolic sulfonation of small molecules; XBP1(S) activates chaperone genes,11,High,1
Q9Y2I8,WD repeat-containing protein 37 OS=Homo sapiens OX=9606 GN=WDR37 PE=1 SV=2,0,105.881,41,13,135,13,494,54.6,7.23,54661,0,13,1,metabolic process,,protein binding,"Pf00400, Pf05103",22884,ENSG00000047056.14,WDR37,10,,,,0,High,1
P09471-2,Isoform Alpha-2 of Guanine nucleotide-binding protein G(o) subunit alpha OS=Homo sapiens OX=9606 GN=GNAO1,0,105.849,37,13,270,8,354,40.1,5.9,128527,,13,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,"Pf00025, Pf00503",2775,ENSG00000087258.14,GNAO1,16,,Human Thyroid Stimulating Hormone (TSH) signaling pathway; Corticotropin-releasing hormone signaling pathway; G Protein Signaling Pathways; Calcium Regulation in the Cardiac Cell,,4,High,1
Q9BWS9,Chitinase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CHID1 PE=1 SV=1,0,105.796,50,13,130,13,393,44.9,8.63,62886,,13,,defense response;metabolic process;regulation of biological process;response to stimulus;transport,endosome;extracellular;membrane;nucleus;organelle lumen;vacuole,catalytic activity;protein binding,Pf00704,66005,ENSG00000177830.17,CHID1,11,,,Platelet degranulation,4,High,1
O43399-3,Isoform 3 of Tumor protein D54 OS=Homo sapiens OX=9606 GN=TPD52L2,0,105.779,66,11,167,1,209,22.5,6.7,85538,5.94,10,2,,,RNA binding,Pf04201,7165,ENSG00000101150.17,TPD52L2,20,,,,0,High,1
O00442,RNA 3'-terminal phosphate cyclase OS=Homo sapiens OX=9606 GN=RTCA PE=1 SV=1,0,105.773,38,10,189,10,366,39.3,7.85,90460,4.12,9,1,metabolic process,nucleus,catalytic activity;nucleotide binding;RNA binding,"Pf01137, Pf05189",8634,ENSG00000137996.12,RTCA,1,,,,0,High,1
Q9H853,Putative tubulin-like protein alpha-4B OS=Homo sapiens OX=9606 GN=TUBA4B PE=5 SV=2,0,105.741,17,11,853,2,241,27.5,7.83,456220,,11,,cell organization and biogenesis,cytoplasm;cytoskeleton,catalytic activity;nucleotide binding;structural molecule activity,Pf00091,80086,ENSG00000243910.7,TUBA4B,2,,Parkin-Ubiquitin Proteasomal System pathway,COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Cilium Assembly; Recruitment of NuMA to mitotic centrosomes; Translocation of GLUT4 to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Separation of Sister Chromatids; COPI-mediated anterograde transport; HSP90 chaperone cycle for steroid hormone receptors (SHR); The role of GTSE1 in G2/M progression after G2 checkpoint; Kinesins; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; Post-chaperonin tubulin folding pathway; MHC class II antigen presentation,57,High,1
Q9Y6I3,Epsin-1 OS=Homo sapiens OX=9606 GN=EPN1 PE=1 SV=2,0,105.721,30,13,89,12,576,60.3,4.83,38270,0,13,1,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus,protein binding,Pf01417,29924,ENSG00000063245.14,EPN1,19,Endocytosis,VEGFA-VEGFR2 Signaling Pathway; EGF/EGFR Signaling Pathway,Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation,11,High,1
Q16644,MAP kinase-activated protein kinase 3 OS=Homo sapiens OX=9606 GN=MAPKAPK3 PE=1 SV=1,0,105.695,46,13,142,9,382,43,7.28,60813,14.72,13,1,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf07714",7867,ENSG00000114738.10,MAPKAPK3,3,MAPK signaling pathway; VEGF signaling pathway,Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation,p38MAPK events; VEGFA-VEGFR2 Pathway; Activated TLR4 signalling; activated TAK1 mediates p38 MAPK activation; Oxidative Stress Induced Senescence,40,High,1
Q9Y241,"HIG1 domain family member 1A, mitochondrial OS=Homo sapiens OX=9606 GN=HIGD1A PE=1 SV=1",0,105.668,84,7,399,7,93,10.1,9.79,161564,58.63,6,2,metabolic process;regulation of biological process;response to stimulus;transport,membrane;mitochondrion,,Pf04588,25994,ENSG00000181061.13,HIGD1A,3,,,Regulation of gene expression by Hypoxia-inducible Factor,5,High,1
P13693,Translationally-controlled tumor protein OS=Homo sapiens OX=9606 GN=TPT1 PE=1 SV=1,0,105.65,54,8,456,8,172,19.6,4.93,224647,1.77,8,1,cell differentiation;cellular homeostasis;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;nucleus,metal ion binding;protein binding;RNA binding,Pf00838,7178,ENSG00000133112.16,TPT1,13,,,,0,High,1
Q7RTP6,[F-actin]-monooxygenase MICAL3 OS=Homo sapiens OX=9606 GN=MICAL3 PE=1 SV=2,0,105.65,14,21,69,21,2002,224.2,5.55,28872,3.16,20,1,cell division;cell organization and biogenesis;metabolic process;transport,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00307, Pf00412, Pf00890, Pf01266, Pf01494, Pf01946, Pf03486, Pf07992, Pf11971, Pf12130, Pf13450",57553,ENSG00000243156.7,MICAL3,22,,,,0,High,1
Q9UNS2,COP9 signalosome complex subunit 3 OS=Homo sapiens OX=9606 GN=COPS3 PE=1 SV=3,0,105.552,38,12,197,12,423,47.8,6.65,88599,,12,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,protein binding,Pf01399,8533,ENSG00000141030.12,COPS3,17,,,Cargo recognition for clathrin-mediated endocytosis; DNA Damage Recognition in GG-NER; Formation of TC-NER Pre-Incision Complex; Neddylation,13,High,1
Q9H0R4,Haloacid dehalogenase-like hydrolase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=HDHD2 PE=1 SV=1,0,105.513,56,11,211,11,259,28.5,6.24,105990,0,11,1,metabolic process,,catalytic activity;metal ion binding;protein binding,"Pf00702, Pf13242, Pf13344, Pf13419",84064,ENSG00000167220.11,HDHD2,18,,,,0,High,1
P07358,Complement component C8 beta chain OS=Homo sapiens OX=9606 GN=C8B PE=1 SV=3,0,105.495,26,11,119,11,591,67,8.13,60673,,11,,defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,protein binding,"Pf00057, Pf01823",732,,C8B,1,Systemic lupus erythematosus; Prion diseases; Complement and coagulation cascades; Amoebiasis,Allograft Rejection; Complement Activation,Terminal pathway of complement; Regulation of Complement cascade,11,High,1
Q6IAN0,Dehydrogenase/reductase SDR family member 7B OS=Homo sapiens OX=9606 GN=DHRS7B PE=1 SV=2,0,105.419,38,12,173,12,325,35.1,9.55,87484,0,12,1,metabolic process,endoplasmic reticulum;membrane,catalytic activity,"Pf00106, Pf08659, Pf13460, Pf13561",25979,ENSG00000109016.17,DHRS7B,17,,,,0,High,1
P36955,Pigment epithelium-derived factor OS=Homo sapiens OX=9606 GN=SERPINF1 PE=1 SV=4,0,105.361,51,14,151,14,418,46.3,6.38,62572,5.96,14,1,cell proliferation;cellular homeostasis;development;regulation of biological process;response to stimulus,extracellular,enzyme regulator activity;protein binding,Pf00079,5176,ENSG00000132386.10,SERPINF1,17,Wnt signaling pathway,,,1,High,1
P60981,Destrin OS=Homo sapiens OX=9606 GN=DSTN PE=1 SV=3,0,105.323,48,10,719,9,165,18.5,7.85,303555,2.03,9,2,cell organization and biogenesis;regulation of biological process,cytoplasm;cytoskeleton,protein binding,Pf00241,11034,ENSG00000125868.15,DSTN,20,,Androgen receptor signaling pathway,,1,High,1
P52566,Rho GDP-dissociation inhibitor 2 OS=Homo sapiens OX=9606 GN=ARHGDIB PE=1 SV=3,0,105.229,59,12,118,12,201,23,5.21,51254,,12,,cellular component movement;development;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane,catalytic activity;enzyme regulator activity;protein binding,Pf02115,397,ENSG00000111348.8,ARHGDIB,12,Neurotrophin signaling pathway; Vasopressin-regulated water reabsorption,Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation; G13 Signaling Pathway,Rho GTPase cycle,7,High,1
Q6VY07,Phosphofurin acidic cluster sorting protein 1 OS=Homo sapiens OX=9606 GN=PACS1 PE=1 SV=2,0,105.191,30,19,118,18,963,104.8,7.74,56072,,19,,cell organization and biogenesis;regulation of biological process;transport,cytosol;Golgi,protein binding,Pf10254,55690,ENSG00000175115.11,PACS1,11,,,Nef mediated downregulation of MHC class I complex cell surface expression,7,High,1
O95433,Activator of 90 kDa heat shock protein ATPase homolog 1 OS=Homo sapiens OX=9606 GN=AHSA1 PE=1 SV=1,0,105.189,49,12,101,12,338,38.3,5.53,48794,,12,,regulation of biological process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum,enzyme regulator activity;protein binding,"Pf08327, Pf09229",10598,ENSG00000100591.7,AHSA1,14,,T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection,,1,High,1
Q86TP1,Exopolyphosphatase PRUNE1 OS=Homo sapiens OX=9606 GN=PRUNE1 PE=1 SV=2,0,105.182,33,12,173,12,453,50.2,5.5,84580,,12,,metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;protein binding,"Pf01368, Pf02833",58497,ENSG00000143363.15,PRUNE; PRUNE1,1,Purine metabolism,,,1,High,1
Q96CW1,AP-2 complex subunit mu OS=Homo sapiens OX=9606 GN=AP2M1 PE=1 SV=2,0,105.17,40,16,266,16,435,49.6,9.54,100811,0,16,1,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;membrane,protein binding;transporter activity,Pf00928,1173,ENSG00000161203.13,AP2M1,3,Synaptic vesicle cycle; Huntington's disease; Endocrine and other factor-regulated calcium reabsorption; Endocytosis,Synaptic Vesicle Pathway; EGF/EGFR Signaling Pathway,"Cargo recognition for clathrin-mediated endocytosis; Nef mediated downregulation of CD28 cell surface expression; Formation of annular gap junctions; Nef Mediated CD8 Down-regulation; Nef Mediated CD4 Down-regulation; Recycling pathway of L1; LDL clearance; EPH-ephrin mediated repulsion of cells; Retrograde neurotrophin signalling; VLDLR internalisation and degradation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; MHC class II antigen presentation; WNT5A-dependent internalization of FZD4",47,High,1
P30046,D-dopachrome decarboxylase OS=Homo sapiens OX=9606 GN=DDT PE=1 SV=3,0,105.169,66,12,529,12,118,12.7,7.3,255416,2.22,11,1,metabolic process;regulation of biological process,cytoplasm,catalytic activity;protein binding,Pf01187,1652,ENSG00000099977.13; ENSG00000275003.3,DDT,22; CHR_HSCHR22_1_CTG7,,,,0,High,1
Q8NCW5,NAD(P)H-hydrate epimerase OS=Homo sapiens OX=9606 GN=NAXE PE=1 SV=2,0,105.109,38,9,576,9,288,31.7,7.66,292335,4.48,8,1,cell organization and biogenesis;metabolic process,cytosol;extracellular;mitochondrion;nucleus;organelle lumen,catalytic activity;metal ion binding;nucleotide binding;protein binding,Pf03853,128240,ENSG00000163382.11,APOA1BP; NAXE,1,,,Nicotinamide salvaging,5,High,1
Q00059,"Transcription factor A, mitochondrial OS=Homo sapiens OX=9606 GN=TFAM PE=1 SV=1",0,105.076,37,12,493,12,246,29.1,9.72,244258,0,12,1,cell organization and biogenesis;metabolic process;regulation of biological process,cytosol;mitochondrion;nucleus;organelle lumen,DNA binding;protein binding;RNA binding,"Pf00505, Pf09011",7019,ENSG00000108064.10,TFAM,10,Huntington's disease,"Energy Metabolism; NAD metabolism, sirtuins and aging; Mitochondrial Gene Expression",Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis,10,High,1
P25789,Proteasome subunit alpha type-4 OS=Homo sapiens OX=9606 GN=PSMA4 PE=1 SV=1,0,104.91,48,11,210,11,261,29.5,7.72,97126,16.46,9,2,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus;proteasome,catalytic activity;protein binding,"Pf00227, Pf10584",5685,ENSG00000041357.15,PSMA4,15,Proteasome,Proteasome Degradation; Exercise-induced Circadian Regulation,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,151,High,1
P60903,Protein S100-A10 OS=Homo sapiens OX=9606 GN=S100A10 PE=1 SV=2,0,104.848,36,7,532,7,97,11.2,7.37,251144,,7,,cell organization and biogenesis;regulation of biological process;response to stimulus,endoplasmic reticulum;extracellular;membrane,metal ion binding;protein binding,Pf01023,6281,ENSG00000197747.8,S100A10,1,,Prostaglandin Synthesis and Regulation,Dissolution of Fibrin Clot,3,High,1
Q9UBF2,Coatomer subunit gamma-2 OS=Homo sapiens OX=9606 GN=COPG2 PE=1 SV=1,0,104.786,26,18,116,17,871,97.6,5.81,52510,0,18,1,transport,cytoplasm;cytosol;Golgi;membrane,structural molecule activity,"Pf01602, Pf08752, Pf13646",26958,ENSG00000158623.14,COPG2,7,,,COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport,11,High,1
P55795,Heterogeneous nuclear ribonucleoprotein H2 OS=Homo sapiens OX=9606 GN=HNRNPH2 PE=1 SV=1,0,104.684,25,8,236,4,449,49.2,6.3,126024,0,8,2,metabolic process,cytosol;membrane;nucleus,protein binding;RNA binding,"Pf00076, Pf08080, Pf14259",3188,ENSG00000126945.8,HNRNPH2,X,,mRNA Processing,mRNA Splicing - Major Pathway,5,High,1
P56181,"NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFV3 PE=1 SV=2",0,104.637,60,10,275,2,108,11.9,9.7,153487,,10,,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion,catalytic activity;RNA binding,,4731,ENSG00000160194.17,NDUFV3,21,Alzheimer's disease; Non-alcoholic fatty liver disease (NAFLD); Huntington's disease; Metabolic pathways; Oxidative phosphorylation; Parkinson's disease,Electron Transport Chain; Oxidative phosphorylation,Complex I biogenesis,13,High,1
Q9P0V9,Septin-10 OS=Homo sapiens OX=9606 GN=SEPTIN10 PE=1 SV=2,0,104.497,38,12,117,10,454,52.6,6.8,54410,,12,,cell division,cytoplasm;cytoskeleton,nucleotide binding;protein binding,Pf00735,151011,ENSG00000186522.14,SEPT10,2,,,,0,High,1
Q9H479,Fructosamine-3-kinase OS=Homo sapiens OX=9606 GN=FN3K PE=1 SV=1,0,104.351,41,10,197,10,309,35.1,7.55,101157,10.53,9,2,cell differentiation;metabolic process,cytosol,catalytic activity;enzyme regulator activity,"Pf01636, Pf03881",64122,ENSG00000167363.13,FN3K,17,,,"Gamma carboxylation, hypusine formation and arylsulfatase activation",3,High,1
Q9NZU5,LIM and cysteine-rich domains protein 1 OS=Homo sapiens OX=9606 GN=LMCD1 PE=1 SV=1,0,104.34,42,13,105,13,365,40.8,7.93,49615,2.04,13,2,metabolic process;regulation of biological process,cytoplasm;nucleus,metal ion binding,"Pf00412, Pf06297",29995,ENSG00000071282.11,LMCD1,3,,,Surfactant metabolism,2,High,1
Q8WW59,SPRY domain-containing protein 4 OS=Homo sapiens OX=9606 GN=SPRYD4 PE=1 SV=2,0,104.32,59,12,306,12,207,23.1,6.93,139621,3.28,12,2,,mitochondrion;nucleus,protein binding,"Pf00622, Pf13765",283377,,SPRYD4,12,,,,0,High,1
Q9Y6Y8,SEC23-interacting protein OS=Homo sapiens OX=9606 GN=SEC23IP PE=1 SV=1,0,104.289,22,15,97,15,1000,111,5.54,41509,,15,,cell organization and biogenesis;transport,cytoplasm;cytosol;endoplasmic reticulum;Golgi;membrane,catalytic activity;metal ion binding;protein binding;RNA binding,"Pf00536, Pf02862, Pf07647",11196,ENSG00000107651.12,SEC23IP,10,,,COPII (Coat Protein 2) Mediated Vesicle Transport,8,High,1
Q14699,Raftlin OS=Homo sapiens OX=9606 GN=RFTN1 PE=1 SV=4,0,104.285,34,13,104,13,578,63.1,5.67,44282,2.97,12,1,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;endosome;membrane,RNA binding,Pf15250,23180,ENSG00000131378.13,RFTN1,3,,,,0,High,1
Q9NRW7,Vacuolar protein sorting-associated protein 45 OS=Homo sapiens OX=9606 GN=VPS45 PE=1 SV=1,0,104.238,34,17,148,17,570,65,8.24,66837,,17,,coagulation;transport,endosome;Golgi;membrane,protein binding,Pf00995,11311,ENSG00000136631.12,VPS45,1,Endocytosis,,Intra-Golgi traffic; Factors involved in megakaryocyte development and platelet production,7,High,1
P06681,Complement C2 OS=Homo sapiens OX=9606 GN=C2 PE=1 SV=2,0,104.208,21,15,144,15,752,83.2,7.42,61049,0,15,2,defense response;metabolic process;regulation of biological process;response to stimulus,extracellular,catalytic activity;metal ion binding;protein binding,"Pf00084, Pf00089, Pf00092, Pf09342, Pf13519",717,ENSG00000231543.9; ENSG00000204364.10; ENSG00000226560.10; ENSG00000235696.8; ENSG00000166278.14; ENSG00000235017.9; ENSG00000206372.11,C2,6; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_QBL_CTG1,Staphylococcus aureus infection; Pertussis; Complement and coagulation cascades; Systemic lupus erythematosus,Allograft Rejection; Oxidative Damage; Complement Activation; Complement and Coagulation Cascades,Initial triggering of complement; Regulation of Complement cascade; Activation of C3 and C5,14,High,1
O14576-2,Isoform 2 of Cytoplasmic dynein 1 intermediate chain 1 OS=Homo sapiens OX=9606 GN=DYNC1I1,0,104.177,31,13,70,11,628,70.7,5.08,29353,21.5,11,4,cell organization and biogenesis;cellular component movement;regulation of biological process;transport,chromosome;cytoplasm;cytosol;endosome;nucleus,catalytic activity;motor activity;protein binding,"Pf00400, Pf11540",1780,ENSG00000158560.14,DYNC1I1,7,,,,0,High,1
Q9BW91,"ADP-ribose pyrophosphatase, mitochondrial OS=Homo sapiens OX=9606 GN=NUDT9 PE=1 SV=1",0,104.106,33,11,135,11,350,39.1,8.22,58493,2.07,11,2,metabolic process,membrane;mitochondrion;organelle lumen,catalytic activity,Pf00293,53343,ENSG00000170502.12,NUDT9,4,Purine metabolism,,Phosphate bond hydrolysis by NUDT proteins,6,High,1
P46060,Ran GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RANGAP1 PE=1 SV=1,0,103.989,40,15,90,15,587,63.5,4.68,38519,0,15,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;cytoskeleton;cytosol;membrane;nucleus,enzyme regulator activity;protein binding;RNA binding,"Pf07834, Pf13855",5905,ENSG00000100401.19,RANGAP1,22,RNA transport,,Rev-mediated nuclear export of HIV RNA; SUMOylation of DNA replication proteins; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins,30,High,1
O95861,"3'(2'),5'-bisphosphate nucleotidase 1 OS=Homo sapiens OX=9606 GN=BPNT1 PE=1 SV=1",0,103.904,37,11,210,11,308,33.4,5.69,95348,7.25,10,3,metabolic process,cytosol,catalytic activity;metal ion binding,Pf00459,10380,ENSG00000162813.17,BPNT1,1,Sulfur metabolism; Metabolic pathways,,Cytosolic sulfonation of small molecules,6,High,1
P02750,Leucine-rich alpha-2-glycoprotein OS=Homo sapiens OX=9606 GN=LRG1 PE=1 SV=2,0,103.849,33,11,300,11,347,38.2,6.95,152662,1.62,11,1,cell differentiation;regulation of biological process;transport,extracellular;membrane;organelle lumen,protein binding,"Pf12799, Pf13855",116844,ENSG00000171236.9,LRG1,19,,,Neutrophil degranulation,3,High,1
P09382,Galectin-1 OS=Homo sapiens OX=9606 GN=LGALS1 PE=1 SV=2,0,103.787,73,9,457,9,135,14.7,5.5,185970,188.13,6,4,cell death;cell differentiation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cell surface;cytoplasm;cytosol;extracellular;nucleus;organelle lumen,protein binding;RNA binding;signal transducer activity,Pf00337,3956,ENSG00000100097.11,LGALS1,22,,,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs),4,High,1
O95163,Elongator complex protein 1 OS=Homo sapiens OX=9606 GN=ELP1 PE=1 SV=3,0,103.729,19,21,91,21,1332,150.2,5.94,38468,,21,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,enzyme regulator activity;protein binding;signal transducer activity,Pf04762,8518,ENSG00000070061.14,IKBKAP; ELP1,9,,,HATs acetylate histones,3,High,1
Q99653,Calcineurin B homologous protein 1 OS=Homo sapiens OX=9606 GN=CHP1 PE=1 SV=3,0,103.596,54,9,121,9,195,22.4,5.1,62035,,9,,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;nucleus,enzyme regulator activity;metal ion binding;protein binding;transporter activity,"Pf00036, Pf12174, Pf13405, Pf13499, Pf13833",11261,ENSG00000187446.11,CHP1,15,,Alzheimers Disease; T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection,Hyaluronan uptake and degradation,7,High,1
Q8NHW5,60S acidic ribosomal protein P0-like OS=Homo sapiens OX=9606 GN=RPLP0P6 PE=5 SV=1,0,103.559,42,15,291,1,317,34.3,5.55,134475,22.36,14,2,,ribosome,,"Pf00428, Pf00466",220717,,RPLP0P6,2,,,,0,High,1
O43169,Cytochrome b5 type B OS=Homo sapiens OX=9606 GN=CYB5B PE=1 SV=3,0,103.535,66,8,175,8,150,16.7,4.97,90880,23.49,7,2,,,,,,,,,,,,0,High,1
Q96JB5,CDK5 regulatory subunit-associated protein 3 OS=Homo sapiens OX=9606 GN=CDK5RAP3 PE=1 SV=2,0,103.507,31,14,106,14,506,56.9,4.75,51064,,14,,cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,protein binding,Pf05600,80279,ENSG00000108465.14,CDK5RAP3,17,,,,0,High,1
P62495,Eukaryotic peptide chain release factor subunit 1 OS=Homo sapiens OX=9606 GN=ETF1 PE=1 SV=3,0,103.47,38,14,170,14,437,49,5.71,71270,1.7,14,1,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,protein binding;RNA binding,"Pf03463, Pf03464, Pf03465",2107,ENSG00000120705.12,ETF1,5,mRNA surveillance pathway,Translation Factors,Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC),13,High,1
P23258,Tubulin gamma-1 chain OS=Homo sapiens OX=9606 GN=TUBG1 PE=1 SV=2,0,103.338,42,13,123,13,451,51.1,6.14,51825,,13,,cell organization and biogenesis;regulation of biological process,chromosome;cytoplasm;cytoskeleton;cytosol;endosome,catalytic activity;nucleotide binding;protein binding;structural molecule activity,"Pf00091, Pf03953",7283,ENSG00000131462.7,TUBG1,17,,,Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes,16,High,1
O75190,DnaJ homolog subfamily B member 6 OS=Homo sapiens OX=9606 GN=DNAJB6 PE=1 SV=2,0,103.242,47,10,155,1,326,36.1,9.16,73726,28.09,8,4,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;nucleus,DNA binding;enzyme regulator activity;protein binding,Pf00226,10049,ENSG00000105993.14,DNAJB6,7,,,Regulation of HSF1-mediated heat shock response,4,High,1
Q5T1M5,FK506-binding protein 15 OS=Homo sapiens OX=9606 GN=FKBP15 PE=1 SV=2,0,103.167,20,16,75,16,1219,133.5,5.2,34282,,16,,cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;endosome;extracellular;Golgi;membrane;nucleus,catalytic activity;motor activity;protein binding;structural molecule activity;transporter activity,"Pf00038, Pf00254, Pf00769, Pf01442, Pf01496, Pf01576, Pf01875, Pf02463, Pf03938, Pf03961, Pf03962, Pf04111, Pf04156, Pf04849, Pf05029, Pf05483, Pf05557, Pf05622, Pf05667, Pf05701, Pf05911, Pf06160, Pf06248, Pf07111, Pf07888, Pf07926, Pf08317, Pf08614, Pf09726, Pf09728, Pf09730, Pf09731, Pf09744, Pf09755, Pf09789, Pf10174, Pf10186, Pf10211, Pf10234, Pf10498, Pf11559, Pf12128, Pf12718, Pf12795, Pf13166, Pf13514, Pf13851, Pf13863, Pf13868, Pf14915, Pf14988, Pf14992, Pf15066, Pf15188, Pf15272, Pf15397, Pf15558, Pf15619",23307,ENSG00000119321.8,FKBP15,9,,TYROBP Causal Network,,1,High,1
Q9H3S7,Tyrosine-protein phosphatase non-receptor type 23 OS=Homo sapiens OX=9606 GN=PTPN23 PE=1 SV=1,0,103.021,19,22,90,22,1636,178.9,6.92,35116,,22,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;endosome;nucleus,catalytic activity;protein binding,"Pf00102, Pf03097, Pf05823, Pf13949",25930,ENSG00000076201.14,PTPN23,3,,,,0,High,1
Q12979,Active breakpoint cluster region-related protein OS=Homo sapiens OX=9606 GN=ABR PE=1 SV=2,0,103.006,30,16,94,15,859,97.5,6.55,34321,0,16,1,cell organization and biogenesis;regulation of biological process;response to stimulus,cytosol;membrane,enzyme regulator activity;protein binding,"Pf00168, Pf00169, Pf00620, Pf00621",29,ENSG00000278741.4; ENSG00000159842.14,ABR,17; CHR_HSCHR17_2_CTG2,,,G alpha (12/13) signalling events; NRAGE signals death through JNK; Signalling by NGF; Rho GTPase cycle,11,High,1
Q99424,Peroxisomal acyl-coenzyme A oxidase 2 OS=Homo sapiens OX=9606 GN=ACOX2 PE=1 SV=1,0,102.998,34,20,98,20,681,76.8,7.56,41833,,20,,metabolic process;regulation of biological process,mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding,"Pf01756, Pf02770, Pf14749",8309,ENSG00000168306.12,ACOX2,3,Peroxisome; Metabolic pathways; Primary bile acid biosynthesis; PPAR signaling pathway,Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis; PPAR signaling pathway,Beta-oxidation of pristanoyl-CoA; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol,15,High,1
Q2TAA2,Isoamyl acetate-hydrolyzing esterase 1 homolog OS=Homo sapiens OX=9606 GN=IAH1 PE=1 SV=1,0,102.904,46,10,199,10,248,27.6,5.3,102242,,10,,metabolic process,,catalytic activity,"Pf00657, Pf13472",285148,ENSG00000134330.18,IAH1,2,,,,0,High,1
P62136,Serine/threonine-protein phosphatase PP1-alpha catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CA PE=1 SV=1,0,102.878,37,13,295,5,330,37.5,6.33,146531,4.82,12,2,cell division;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,catalytic activity;metal ion binding;protein binding,Pf00149,5499,ENSG00000172531.14,PPP1CA,11,mRNA surveillance pathway; Long-term potentiation; Amphetamine addiction; Herpes simplex infection; Proteoglycans in cancer; Platelet activation; Hippo signaling pathway; Vascular smooth muscle contraction; Adrenergic signaling in cardiomyocytes; cAMP signaling pathway; Inflammatory mediator regulation of TRP channels; Oxytocin signaling pathway; Oocyte meiosis; cGMP-PKG signaling pathway; Regulation of actin cytoskeleton; Insulin signaling pathway; Focal adhesion; Insulin resistance; Dopaminergic synapse; Alcoholism,Nicotine Activity on Dopaminergic Neurons; Common Pathways Underlying Drug Addiction,Signaling by GPCR; Triglyceride catabolism; DARPP-32 events; Downregulation of TGF-beta receptor signaling; Circadian Clock,35,High,1
Q02413,Desmoglein-1 OS=Homo sapiens OX=9606 GN=DSG1 PE=1 SV=2,0,102.866,20,13,71,13,1049,113.7,5.03,31359,,13,,cell death;cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoskeleton;cytosol;membrane,metal ion binding;protein binding,"Pf00028, Pf01049",1828,ENSG00000134760.5,DSG1,18,Staphylococcus aureus infection,,Apoptotic cleavage of cell adhesion  proteins; Formation of the cornified envelope; Neutrophil degranulation,12,High,1
P27694,Replication protein A 70 kDa DNA-binding subunit OS=Homo sapiens OX=9606 GN=RPA1 PE=1 SV=2,0,102.788,33,15,134,15,616,68.1,7.21,56594,0,15,1,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,nucleus,DNA binding;metal ion binding;protein binding,"Pf01336, Pf01485, Pf04057, Pf08646",6117,ENSG00000132383.11,RPA1,17,Mismatch repair; DNA replication; Nucleotide excision repair; Fanconi anemia pathway; Homologous recombination,Homologous recombination; Retinoblastoma (RB) in Cancer; ATR Signaling; G1 to S cell cycle control; DNA Replication; Mismatch repair,Translesion Synthesis by POLH; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Activation of the pre-replicative complex; Termination of translesion DNA synthesis; Translesion synthesis by POLI; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Meiotic recombination; Removal of the Flap Intermediate; Regulation of TP53 Activity through Phosphorylation; PCNA-Dependent Long Patch Base Excision Repair; G2/M DNA damage checkpoint; Translesion synthesis by POLK; Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Gap-filling DNA repair synthesis and ligation in TC-NER; Regulation of HSF1-mediated heat shock response; Presynaptic phase of homologous DNA pairing and strand exchange; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Fanconi Anemia Pathway; HSF1 activation; M/G1 Transition; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA); Removal of the Flap Intermediate from the C-strand; SUMOylation of DNA damage response and repair proteins,87,High,1
Q99816,Tumor susceptibility gene 101 protein OS=Homo sapiens OX=9606 GN=TSG101 PE=1 SV=2,0,102.772,37,14,137,14,390,43.9,6.46,63076,2.26,14,1,cell communication;cell differentiation;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endosome;membrane;nucleus,DNA binding;protein binding,"Pf03148, Pf04111, Pf04156, Pf05743, Pf07798, Pf09454, Pf11932, Pf12325, Pf13863, Pf15346",7251,ENSG00000074319.12,TSG101,11,Endocytosis,,Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); Membrane binding and targetting of GAG proteins,13,High,1
P61020,Ras-related protein Rab-5B OS=Homo sapiens OX=9606 GN=RAB5B PE=1 SV=1,0,102.722,53,11,253,5,215,23.7,8.13,124105,0,11,2,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,endosome;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00009, Pf00025, Pf00071, Pf04670, Pf08477",5869,ENSG00000111540.15,RAB5B,12,Phagosome; Endocytosis; Ras signaling pathway; Tuberculosis; Vasopressin-regulated water reabsorption; Amoebiasis,,TBC/RABGAPs; Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Clathrin-mediated endocytosis,18,High,1
Q96HS1,"Serine/threonine-protein phosphatase PGAM5, mitochondrial OS=Homo sapiens OX=9606 GN=PGAM5 PE=1 SV=2",0,102.693,59,19,120,19,289,32,8.68,50414,,19,,cell communication;cell death;metabolic process;regulation of biological process;response to stimulus,membrane;mitochondrion,catalytic activity;enzyme regulator activity;protein binding;signal transducer activity,Pf00300,192111,ENSG00000247077.6,PGAM5,12,TNF signaling pathway,,,1,High,1
P82675,"28S ribosomal protein S5, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS5 PE=1 SV=2",0,102.61,30,14,210,14,430,48,9.92,96271,,14,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,RNA binding;structural molecule activity,"Pf00333, Pf03719",64969,ENSG00000144029.11,MRPS5,2,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
P15090,"Fatty acid-binding protein, adipocyte OS=Homo sapiens OX=9606 GN=FABP4 PE=1 SV=3",0,102.57,67,9,1178,8,132,14.7,7.14,492056,14.08,8,2,cell differentiation;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus,transporter activity,"Pf00061, Pf14651",2167,ENSG00000170323.8,FABP4,8,Regulation of lipolysis in adipocytes; PPAR signaling pathway,PPAR signaling pathway,Triglyceride catabolism; Transcriptional regulation of white adipocyte differentiation,9,High,1
Q7L775,EPM2A-interacting protein 1 OS=Homo sapiens OX=9606 GN=EPM2AIP1 PE=1 SV=1,0,102.567,28,11,107,11,607,70.3,6.11,50973,,11,,regulation of biological process;response to stimulus,cytoplasm;endoplasmic reticulum;nucleus,DNA binding;protein binding,,9852,ENSG00000178567.7,EPM2AIP1,3,,,,0,High,1
P00966,Argininosuccinate synthase OS=Homo sapiens OX=9606 GN=ASS1 PE=1 SV=2,0,102.56,43,16,176,16,412,46.5,8.02,76611,,16,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;mitochondrion,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00764, Pf03054, Pf06508",445,ENSG00000130707.17,ASS1,9,"Biosynthesis of amino acids; Alanine, aspartate and glutamate metabolism; Metabolic pathways; Arginine biosynthesis",Alanine and aspartate metabolism; Amino Acid metabolism; Urea cycle and metabolism of amino groups,Urea cycle,11,High,1
Q9GZS3,WD repeat-containing protein 61 OS=Homo sapiens OX=9606 GN=WDR61 PE=1 SV=1,0,102.551,51,12,94,12,305,33.6,5.47,40629,,12,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,protein binding,"Pf00400, Pf07433, Pf13360",80349,ENSG00000140395.8,WDR61,15,RNA degradation,,mRNA decay by 3' to 5' exoribonuclease; E3 ubiquitin ligases ubiquitinate target proteins; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events,13,High,1
P62826,GTP-binding nuclear protein Ran OS=Homo sapiens OX=9606 GN=RAN PE=1 SV=3,0,102.502,43,13,437,13,216,24.4,7.49,201378,5.45,13,2,cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,chromosome;cytoplasm;cytosol;endosome;membrane;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding;transporter activity,"Pf00025, Pf00071, Pf08477",5901,ENSG00000132341.11,RAN,12,HTLV-I infection; Epstein-Barr virus infection; RNA transport; Ribosome biogenesis in eukaryotes,Androgen receptor signaling pathway; miRNA Biogenesis,MicroRNA (miRNA) biogenesis; Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; Regulation of cholesterol biosynthesis by SREBP (SREBF); NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs,30,High,1
Q9BZV1,UBX domain-containing protein 6 OS=Homo sapiens OX=9606 GN=UBXN6 PE=1 SV=1,0,102.422,49,14,95,14,441,49.7,6.89,40830,,14,,cell communication;metabolic process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endosome;membrane;nucleus;vacuole,protein binding,"Pf00789, Pf09409",80700,ENSG00000167671.11,UBXN6,19,Protein processing in endoplasmic reticulum,,,1,High,1
Q96ER9,Mitochondrial potassium channel OS=Homo sapiens OX=9606 GN=CCDC51 PE=1 SV=2,0,102.418,29,12,133,11,411,45.8,8.19,63027,0,12,2,,membrane;mitochondrion,,,79714,ENSG00000164051.13,CCDC51,3,,,,0,High,1
Q8TDX7,Serine/threonine-protein kinase Nek7 OS=Homo sapiens OX=9606 GN=NEK7 PE=1 SV=1,0,102.368,41,11,152,6,302,34.5,8.25,72348,,11,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytoskeleton;nucleus,catalytic activity;metal ion binding;nucleotide binding,"Pf00069, Pf07714, Pf14531",140609,ENSG00000151414.14,NEK7,1,NOD-like receptor signaling pathway,,"Activation of NIMA Kinases NEK9, NEK6, NEK7; Nuclear Pore Complex (NPC) Disassembly",8,High,1
P51148,Ras-related protein Rab-5C OS=Homo sapiens OX=9606 GN=RAB5C PE=1 SV=2,0,102.342,53,11,223,5,216,23.5,8.41,109235,,11,,regulation of biological process;response to stimulus;transport,endosome;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00009, Pf00025, Pf00071, Pf04670, Pf08477",5878,ENSG00000108774.14,RAB5C,17,Amoebiasis; Phagosome; Endocytosis; Vasopressin-regulated water reabsorption; Ras signaling pathway; Tuberculosis,,TBC/RABGAPs; Neutrophil degranulation; Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation,21,High,1
P52565,Rho GDP-dissociation inhibitor 1 OS=Homo sapiens OX=9606 GN=ARHGDIA PE=1 SV=3,0,102.279,37,5,156,5,204,23.2,5.11,94741,0,5,1,cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol,enzyme regulator activity;protein binding,Pf02115,396,ENSG00000141522.11,ARHGDIA,17,Vasopressin-regulated water reabsorption; Neurotrophin signaling pathway,,Signalling by NGF; Axonal growth inhibition (RHOA activation); Axonal growth stimulation; Rho GTPase cycle,11,High,1
P29966,Myristoylated alanine-rich C-kinase substrate OS=Homo sapiens OX=9606 GN=MARCKS PE=1 SV=4,0,102.245,47,10,116,10,332,31.5,4.45,60600,,10,,cell organization and biogenesis;regulation of biological process,cytoplasm;cytoskeleton;membrane;nucleus,protein binding,,4082,ENSG00000277443.2,MARCKS,6,MicroRNAs in cancer; Fc gamma R-mediated phagocytosis,Brain-Derived Neurotrophic Factor (BDNF) signaling pathway,Acetylcholine regulates insulin secretion,7,High,1
Q9Y2H1,Serine/threonine-protein kinase 38-like OS=Homo sapiens OX=9606 GN=STK38L PE=1 SV=3,0,102.227,35,11,94,11,464,54,6.81,44663,,11,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf00433, Pf01636, Pf07714, Pf14531",23012,ENSG00000211455.7,STK38L,12,,,,0,High,1
Q96CX2,BTB/POZ domain-containing protein KCTD12 OS=Homo sapiens OX=9606 GN=KCTD12 PE=1 SV=1,0,102.112,46,12,150,11,325,35.7,5.64,69466,0,12,1,cell organization and biogenesis;transport,membrane,protein binding;RNA binding;transporter activity,Pf02214,115207,ENSG00000178695.5,KCTD12,13,,,,0,High,1
P14854,Cytochrome c oxidase subunit 6B1 OS=Homo sapiens OX=9606 GN=COX6B1 PE=1 SV=2,0,102.037,86,13,392,13,86,10.2,7.05,182598,92.44,11,4,metabolic process;transport,membrane;mitochondrion,catalytic activity;transporter activity,Pf02297,1340,ENSG00000126267.8,COX6B1,19,Non-alcoholic fatty liver disease (NAFLD); Huntington's disease; Alzheimer's disease; Metabolic pathways; Oxidative phosphorylation; Parkinson's disease; Cardiac muscle contraction,Electron Transport Chain,TP53 Regulates Metabolic Genes; Respiratory electron transport,17,High,1
P11498,"Pyruvate carboxylase, mitochondrial OS=Homo sapiens OX=9606 GN=PC PE=1 SV=2",0,101.999,23,18,82,18,1178,129.6,6.84,32183,0,18,1,metabolic process;regulation of biological process,cytoplasm;cytosol;mitochondrion;organelle lumen,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00289, Pf00364, Pf00682, Pf02222, Pf02436, Pf02785, Pf02786, Pf07478, Pf08443, Pf13533, Pf13535, Pf15632",5091,ENSG00000173599.13,PC,11,Pyruvate metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; Citrate cycle (TCA cycle),Alanine and aspartate metabolism; TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc); Fatty Acid Biosynthesis; Amino Acid metabolism; Glycolysis and Gluconeogenesis,Gluconeogenesis; Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency,22,High,1
Q9Y608,Leucine-rich repeat flightless-interacting protein 2 OS=Homo sapiens OX=9606 GN=LRRFIP2 PE=1 SV=1,0,101.795,35,18,93,16,721,82.1,6.95,33807,24.51,13,5,metabolic process;regulation of biological process;response to stimulus,,catalytic activity;motor activity;protein binding,"Pf01576, Pf02463, Pf04111, Pf05557, Pf09738, Pf13514, Pf13870",9209,ENSG00000093167.17,LRRFIP2,3,,,,0,High,1
Q16658,Fascin OS=Homo sapiens OX=9606 GN=FSCN1 PE=1 SV=3,0,101.79,33,13,168,13,493,54.5,7.24,81376,,13,,cell organization and biogenesis;cell proliferation;cellular component movement;regulation of biological process,cytoplasm;cytoskeleton;cytosol,protein binding;RNA binding,Pf06268,6624,ENSG00000075618.17,FSCN1,7,MicroRNAs in cancer,,Interleukin-4 and 13 signaling,5,High,1
O95671,Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein OS=Homo sapiens OX=9606 GN=ASMTL PE=1 SV=3,0,101.789,33,16,169,16,621,68.8,6.07,73275,0,15,1,metabolic process,cytoplasm;cytosol,catalytic activity;protein binding,"Pf00891, Pf02545, Pf08241, Pf08242, Pf12847, Pf13649, Pf13659",8623,ENSG00000169093.15,ASMTL,X|Y; X,,,,0,High,1
O94788,Retinal dehydrogenase 2 OS=Homo sapiens OX=9606 GN=ALDH1A2 PE=1 SV=3,0,101.754,40,16,314,12,518,56.7,6.05,134649,0,16,1,cell differentiation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,catalytic activity,"Pf00171, Pf05893",8854,ENSG00000128918.14,ALDH1A2,15,Retinol metabolism; Metabolic pathways,Tryptophan metabolism; Vitamin A and Carotenoid Metabolism,RA biosynthesis pathway,8,High,1
Q9HA77,"Probable cysteine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=CARS2 PE=1 SV=1",0,101.742,28,13,198,13,564,62.2,8.34,95621,7.99,12,3,metabolic process,cytoplasm;mitochondrion;organelle lumen,catalytic activity;metal ion binding;nucleotide binding,"Pf00133, Pf01406, Pf01921, Pf09334",79587,ENSG00000134905.16,CARS2,13,Aminoacyl-tRNA biosynthesis,,Mitochondrial tRNA aminoacylation,5,High,1
O00303,Eukaryotic translation initiation factor 3 subunit F OS=Homo sapiens OX=9606 GN=EIF3F PE=1 SV=1,0,101.625,36,9,178,9,357,37.5,5.45,83931,1.7,9,1,metabolic process,cytoplasm;cytosol;membrane,catalytic activity;protein binding;RNA binding,"Pf01398, Pf13012",8665,ENSG00000280606.3; ENSG00000175390.13,EIF3F,11; CHR_HSCHR11_1_CTG1_2,RNA transport,Translation Factors,"Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Ribosomal scanning and start codon recognition",13,High,1
Q5H9R7,Serine/threonine-protein phosphatase 6 regulatory subunit 3 OS=Homo sapiens OX=9606 GN=PPP6R3 PE=1 SV=2,0,101.619,24,17,73,17,873,97.6,4.6,32394,,17,,cell organization and biogenesis;regulation of biological process,cytoplasm;cytosol;membrane;nucleus,protein binding,Pf04499,55291,ENSG00000110075.14,PPP6R3,11,,,COPII (Coat Protein 2) Mediated Vesicle Transport,8,High,1
Q99747,Gamma-soluble NSF attachment protein OS=Homo sapiens OX=9606 GN=NAPG PE=1 SV=1,0,101.568,37,10,135,10,312,34.7,5.41,61300,,10,,cell organization and biogenesis;regulation of biological process;transport,membrane;mitochondrion,protein binding,Pf14938,8774,ENSG00000134265.12,NAPG,18,,,COPI-dependent Golgi-to-ER retrograde traffic; Intra-Golgi traffic; COPII (Coat Protein 2) Mediated Vesicle Transport; COPI-mediated anterograde transport; Retrograde transport at the Trans-Golgi-Network,14,High,1
P62070,Ras-related protein R-Ras2 OS=Homo sapiens OX=9606 GN=RRAS2 PE=1 SV=1,0,101.517,47,10,242,7,204,23.4,6.01,118881,1.67,10,2,cell differentiation;regulation of biological process;response to stimulus,endoplasmic reticulum;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00071, Pf08477",22800,ENSG00000133818.13,RRAS2,11,cAMP signaling pathway; MAPK signaling pathway; Regulation of actin cytoskeleton; Tight junction; HTLV-I infection; Phospholipase D signaling pathway; Ras signaling pathway; Proteoglycans in cancer,Regulation of Actin Cytoskeleton,,9,High,1
P49789,Bis(5'-adenosyl)-triphosphatase OS=Homo sapiens OX=9606 GN=FHIT PE=1 SV=3,0,101.455,67,8,148,8,147,16.8,7.08,60646,19.93,8,2,cell death;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;mitochondrion;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf01230, Pf11969",2272,ENSG00000189283.9,FHIT,3,Purine metabolism; Non-small cell lung cancer; Small cell lung cancer,,,3,High,1
Q92901,60S ribosomal protein L3-like OS=Homo sapiens OX=9606 GN=RPL3L PE=2 SV=3,0,101.436,36,9,104,8,407,46.3,10.45,29794,148.39,2,8,cell organization and biogenesis;metabolic process,membrane;ribosome,RNA binding;structural molecule activity,Pf00297,6123,ENSG00000140986.7,RPL3L,16,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
O95865,"N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 OS=Homo sapiens OX=9606 GN=DDAH2 PE=1 SV=1",0,101.373,67,12,178,11,285,29.6,6.01,77572,6.59,11,2,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;mitochondrion,catalytic activity;protein binding,Pf02274,23564,ENSG00000233076.6; ENSG00000227317.6; ENSG00000213722.8; ENSG00000228128.6; ENSG00000225635.7; ENSG00000206395.8; ENSG00000226634.6,DDAH2,6; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_COX_CTG1,,,eNOS activation,4,High,1
Q13501,Sequestosome-1 OS=Homo sapiens OX=9606 GN=SQSTM1 PE=1 SV=1,0,101.362,37,14,101,14,440,47.7,5.22,51906,,14,,cell communication;cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;endosome;nucleus;vacuole,catalytic activity;metal ion binding;protein binding,"Pf00564, Pf00569",8878,ENSG00000161011.19,SQSTM1,5,Osteoclast differentiation,Regulation of toll-like receptor signaling pathway; IL-1 signaling pathway; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; NRF2 pathway; Interleukin-1 Induced Activation of NF-kappa-B; Senescence and Autophagy in Cancer,Interleukin-1 family signaling; NF-kB is activated and signals survival; Signalling by NGF; p75NTR recruits signalling complexes; NRIF signals cell death from the nucleus; Pink/Parkin Mediated Mitophagy,24,High,1
O15027,Protein transport protein Sec16A OS=Homo sapiens OX=9606 GN=SEC16A PE=1 SV=4,0,101.315,14,20,70,20,2357,251.7,5.8,24730,22.49,17,3,,,,,,,,,,,,0,High,1
Q16654,"[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial OS=Homo sapiens OX=9606 GN=PDK4 PE=1 SV=1",0,101.131,39,12,133,11,411,46.4,6.65,55471,42.62,10,4,cell communication;metabolic process;regulation of biological process;response to stimulus,membrane;mitochondrion;organelle lumen,catalytic activity;nucleotide binding,"Pf02518, Pf10436",5166,ENSG00000004799.7,PDK4,7,,Estrogen Receptor Pathway; Amino Acid metabolism,Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid,10,High,1
Q9NUQ9,Protein FAM49B OS=Homo sapiens OX=9606 GN=FAM49B PE=1 SV=1,0,101.076,38,11,106,11,324,36.7,6.06,53599,,11,,regulation of biological process;transport,extracellular;membrane;organelle lumen,protein binding,Pf07159,51571,ENSG00000153310.19,FAM49B,8,,,Platelet degranulation,4,High,1
Q15042,Rab3 GTPase-activating protein catalytic subunit OS=Homo sapiens OX=9606 GN=RAB3GAP1 PE=1 SV=3,0,101.068,24,19,103,19,981,110.5,5.55,42129,,19,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytosol;Golgi;membrane,enzyme regulator activity;protein binding,Pf13890,22930,ENSG00000115839.17,RAB3GAP1,2,,,COPI-independent Golgi-to-ER retrograde traffic; RAB GEFs exchange GTP for GDP on RABs,7,High,1
Q9H488,GDP-fucose protein O-fucosyltransferase 1 OS=Homo sapiens OX=9606 GN=POFUT1 PE=1 SV=1,0,100.865,37,9,124,9,388,43.9,8.53,51826,0,9,1,metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;membrane,catalytic activity,Pf10250,23509,ENSG00000101346.13,POFUT1,20,Other types of O-glycan biosynthesis,,Pre-NOTCH Processing in the Endoplasmic Reticulum,5,High,1
O00629,Importin subunit alpha-3 OS=Homo sapiens OX=9606 GN=KPNA4 PE=1 SV=1,0,100.84,24,10,113,7,521,57.9,4.96,54649,2.02,9,1,regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus,protein binding;transporter activity,"Pf00514, Pf01749, Pf13513, Pf13646",3840,ENSG00000186432.8,KPNA4,3,,Leptin signaling pathway,NS1 Mediated Effects on Host Pathways; ISG15 antiviral mechanism,11,High,1
Q14515,SPARC-like protein 1 OS=Homo sapiens OX=9606 GN=SPARCL1 PE=1 SV=2,0,100.775,33,11,80,11,664,75.2,4.81,37243,0,10,1,metabolic process;regulation of biological process;response to stimulus,extracellular;organelle lumen,metal ion binding;protein binding,"Pf00050, Pf07648, Pf09289, Pf10591",8404,ENSG00000152583.12,SPARCL1,4,,,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs),4,High,1
P41222,Prostaglandin-H2 D-isomerase OS=Homo sapiens OX=9606 GN=PTGDS PE=1 SV=1,0,100.719,62,8,140,8,190,21,7.8,70277,,8,,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;extracellular;Golgi;membrane;nucleus,catalytic activity;protein binding;transporter activity,Pf00061,5730,ENSG00000107317.12; ENSG00000284341.1,PTGDS,9,Arachidonic acid metabolism; Metabolic pathways,Eicosanoid Synthesis; Prostaglandin Synthesis and Regulation,Synthesis of Prostaglandins (PG) and Thromboxanes (TX),9,High,1
Q709F0,Acyl-CoA dehydrogenase family member 11 OS=Homo sapiens OX=9606 GN=ACAD11 PE=1 SV=3,0,100.692,29,16,83,16,780,87.2,8.02,34756,0,16,2,,,,,,,,,,,,0,High,1
Q6Y288,"Beta-1,3-glucosyltransferase OS=Homo sapiens OX=9606 GN=B3GLCT PE=1 SV=2",0,100.612,31,12,88,12,498,56.5,7.5,37639,2.43,12,1,metabolic process,endoplasmic reticulum;membrane,catalytic activity,Pf02434,145173,ENSG00000187676.7,B3GALTL; B3GLCT,13,Other types of O-glycan biosynthesis,,O-glycosylation of TSR domain-containing proteins; Defective B3GALTL causes Peters-plus syndrome (PpS),9,High,1
O15173,Membrane-associated progesterone receptor component 2 OS=Homo sapiens OX=9606 GN=PGRMC2 PE=1 SV=1,0,100.597,47,10,202,10,223,23.8,4.88,98722,,10,,regulation of biological process;response to stimulus,membrane,protein binding;receptor activity;signal transducer activity,Pf00173,10424,ENSG00000164040.16,PGRMC2,4,,,,0,High,1
P12035,"Keratin, type II cytoskeletal 3 OS=Homo sapiens OX=9606 GN=KRT3 PE=1 SV=3",0,100.439,12,15,379,1,628,64.4,6.48,185703,8.48,15,1,cell death;cell differentiation;cell organization and biogenesis,cytosol,structural molecule activity,Pf00038,3850,ENSG00000186442.7,KRT3,12,,,Formation of the cornified envelope,3,High,1
P62081,40S ribosomal protein S7 OS=Homo sapiens OX=9606 GN=RPS7 PE=1 SV=1,0,100.408,56,10,441,10,194,22.1,10.1,220709,,10,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;membrane;nucleus;ribosome,protein binding;RNA binding;structural molecule activity,Pf01251,6201,ENSG00000171863.12,RPS7,2,Ribosome,Cytoplasmic Ribosomal Proteins,"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane",39,High,1
P39019,40S ribosomal protein S19 OS=Homo sapiens OX=9606 GN=RPS19 PE=1 SV=2,0,100.387,41,11,452,11,145,16.1,10.32,215162,0,11,3,cell differentiation;cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus;ribosome,protein binding;RNA binding;structural molecule activity,Pf01090,6223,ENSG00000105372.6,RPS19,19,Ribosome,Cytoplasmic Ribosomal Proteins,"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane",38,High,1
B9A064,Immunoglobulin lambda-like polypeptide 5 OS=Homo sapiens OX=9606 GN=IGLL5 PE=2 SV=2,0,100.327,27,9,434,2,214,23,8.84,189099,94.87,8,2,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,extracellular,protein binding,"Pf07654, Pf08205, Pf13927",100423062,ENSG00000254709.7,IGLL5,22,,,,0,High,1
P63092-3,Isoform 3 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short OS=Homo sapiens OX=9606 GN=GNAS,0,100.215,46,15,321,1,379,44.2,6.29,149116,2.34,14,1,metabolic process;regulation of biological process;response to stimulus,cytosol;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,"Pf00025, Pf00503, Pf08477",2778,ENSG00000087460.24,GNAS,20,,Human Thyroid Stimulating Hormone (TSH) signaling pathway; Endothelin Pathways; Corticotropin-releasing hormone signaling pathway; Common Pathways Underlying Drug Addiction; Myometrial Relaxation and Contraction Pathways; G Protein Signaling Pathways; Calcium Regulation in the Cardiac Cell; Estrogen signaling pathway; Serotonin Receptor 4/6/7 and NR3C Signaling,,9,High,1
O95298,NADH dehydrogenase [ubiquinone] 1 subunit C2 OS=Homo sapiens OX=9606 GN=NDUFC2 PE=1 SV=1,0,100.144,47,10,649,10,119,14.2,8.98,317799,0,10,1,cell organization and biogenesis;metabolic process;transport,cytoplasm;membrane;mitochondrion,catalytic activity,Pf06374,4718; 100532726,ENSG00000151366.12,NDUFC2; NDUFC2-KCTD14,11,Metabolic pathways; Alzheimer's disease; Non-alcoholic fatty liver disease (NAFLD); Parkinson's disease; Oxidative phosphorylation; Huntington's disease,Electron Transport Chain; Oxidative phosphorylation,Neutrophil degranulation; Complex I biogenesis,16,High,1
Q8N442,"Translation factor GUF1, mitochondrial OS=Homo sapiens OX=9606 GN=GUF1 PE=1 SV=1",0,100.106,35,18,85,18,669,74.3,8.59,31003,2.27,18,2,metabolic process;regulation of biological process;response to stimulus,membrane;mitochondrion;organelle lumen,catalytic activity;nucleotide binding,"Pf00009, Pf00071, Pf00679, Pf03144, Pf06421, Pf14492",60558,ENSG00000151806.13,GUF1,4,,,,0,High,1
Q9GZM7,Tubulointerstitial nephritis antigen-like OS=Homo sapiens OX=9606 GN=TINAGL1 PE=1 SV=1,0,100.076,26,9,179,9,467,52.4,6.99,85770,,9,,metabolic process;response to stimulus;transport,cytoplasm;extracellular;vacuole,catalytic activity;protein binding;receptor activity;structural molecule activity,"Pf00112, Pf01033",64129,ENSG00000142910.15,TINAGL1,1,,,,0,High,1
P60891,Ribose-phosphate pyrophosphokinase 1 OS=Homo sapiens OX=9606 GN=PRPS1 PE=1 SV=2,0,99.966,31,11,161,6,318,34.8,6.98,77719,4.44,11,3,metabolic process,cytosol,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00156, Pf13793, Pf14572",5631,ENSG00000147224.10,PRPS1,X,Pentose phosphate pathway; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; Purine metabolism,Nucleotide Metabolism,5-Phosphoribose 1-diphosphate biosynthesis,10,High,1
P50502,Hsc70-interacting protein OS=Homo sapiens OX=9606 GN=ST13 PE=1 SV=2,0,99.89,34,11,349,11,369,41.3,5.27,162710,2.01,11,4,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol,nucleotide binding;protein binding,"Pf00515, Pf13371, Pf13414, Pf13431, Pf13432",6767,ENSG00000100380.13,ST13,22,,,Regulation of HSF1-mediated heat shock response,4,High,1
P53004,Biliverdin reductase A OS=Homo sapiens OX=9606 GN=BLVRA PE=1 SV=2,0,99.842,41,12,203,12,296,33.4,6.44,93761,0,12,1,metabolic process,cytoplasm;cytosol,catalytic activity;metal ion binding;protein binding,"Pf01408, Pf09166",644,ENSG00000106605.10,BLVRA,7,Porphyrin and chlorophyll metabolism,,Heme degradation,4,High,1
Q6ZMP0,Thrombospondin type-1 domain-containing protein 4 OS=Homo sapiens OX=9606 GN=THSD4 PE=2 SV=2,0,99.82,19,15,104,15,1018,112.4,7.65,43655,0,15,1,cell organization and biogenesis;metabolic process,extracellular,catalytic activity,"Pf00090, Pf05986, Pf08686",79875,ENSG00000187720.14,THSD4,15,,,O-glycosylation of TSR domain-containing proteins; Defective B3GALTL causes Peters-plus syndrome (PpS),8,High,1
O95278,Laforin OS=Homo sapiens OX=9606 GN=EPM2A PE=1 SV=2,0,99.747,49,14,116,14,331,37.1,6.65,42013,11.91,10,4,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus,catalytic activity;protein binding;receptor activity;signal transducer activity,"Pf00686, Pf00782, Pf03162, Pf05222",7957,ENSG00000112425.14,EPM2A,6,,,Glycogen synthesis; Myoclonic epilepsy of Lafora,9,High,1
Q86V81,THO complex subunit 4 OS=Homo sapiens OX=9606 GN=ALYREF PE=1 SV=3,0,99.62,33,9,70,9,257,26.9,11.15,31106,,9,,cell differentiation;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus;spliceosomal complex,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",10189,,ALYREF,17,mRNA surveillance pathway; RNA transport; Herpes simplex infection; Spliceosome,,mRNA 3'-end processing; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA Splicing - Major Pathway; Transport of the SLBP Dependant Mature mRNA; Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of the SLBP independent Mature mRNA,19,High,1
P0CG47,Polyubiquitin-B OS=Homo sapiens OX=9606 GN=UBB PE=1 SV=1,0,99.588,86,14,1255,14,229,25.7,7.43,666434,3.92,14,3,cell communication;cell organization and biogenesis;cellular component movement;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;mitochondrion;nucleus,protein binding,"Pf00240, Pf11976, Pf13019, Pf13881, Pf14560",7314,ENSG00000170315.13,UBB,17,Parkinson's disease,Proteasome Degradation; Parkinsons Disease Pathway; Dual hijack model of Vif in HIV infection,"NOTCH1 Intracellular Domain Regulates Transcription; Activated NOTCH1 Transmits Signal to the Nucleus; Regulation of RAS by GAPs; UCH proteinases; ISG15 antiviral mechanism; Regulation of PLK1 Activity at G2/M Transition; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Activated TLR4 signalling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Formation of Incision Complex in GG-NER; Separation of Sister Chromatids; DNA Damage Recognition in GG-NER; activated TAK1 mediates p38 MAPK activation; TICAM1,TRAF6-dependent induction of TAK1 complex; APC/C:Cdc20 mediated degradation of Cyclin B; Regulation of RUNX2 expression and activity; Budding and maturation of HIV virion; Amyloid fiber formation; Gap-filling DNA repair synthesis and ligation in TC-NER; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; ABC-family proteins mediated transport; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; NRIF signals cell death from the nucleus; Neddylation; Circadian Clock; Pink/Parkin Mediated Mitophagy; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; Deactivation of the beta-catenin transactivating complex; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; Regulation of RUNX3 expression and activity; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of DNA replication; TICAM1, RIP1-mediated IKK complex recruitment ; HDR through Homologous Recombination (HRR); Negative regulation of MAPK pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; NOTCH2 Activation and Transmission of Signal to the Nucleus; Degradation of GLI2 by the proteasome; Metalloprotease DUBs; Interleukin-20 family signaling; Hedgehog 'on' state; Cargo recognition for clathrin-mediated endocytosis; Spry regulation of FGF signaling; Regulation of necroptotic cell death; Degradation of DVL; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of FZD by ubiquitination; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Asymmetric localization of PCP proteins; Downregulation of ERBB2:ERBB3 signaling; Endosomal Sorting Complex Required For Transport (ESCRT); Downregulation of ERBB4 signaling; Activation of NF-kappaB in B cells; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Processing of DNA double-strand break ends; Regulation of TNFR1 signaling; MAPK6/MAPK4 signaling; Oncogene Induced Senescence; Signalling by NGF; Defective CFTR causes cystic fibrosis; Senescence-Associated Secretory Phenotype (SASP); Oxidative Stress Induced Senescence; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; NOD1/2 Signaling Pathway; APC-Cdc20 mediated degradation of Nek2A; EGFR downregulation; NIK-->noncanonical NF-kB signaling; Ovarian tumor domain proteases; TRAF6-mediated induction of TAK1 complex within TLR4 complex; Association of licensing factors with the pre-replicative complex; Stimuli-sensing channels; Myoclonic epilepsy of Lafora; Membrane binding and targetting of GAG proteins; Termination of translesion DNA synthesis; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling; Regulation of signaling by CBL; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Constitutive Signaling by NOTCH1 HD Domain Mutants; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Ub-specific processing proteases; Translesion synthesis by POLK; Downregulation of TGF-beta receptor signaling; IKK complex recruitment mediated by RIP1; IRAK2 mediated activation of TAK1 complex; Regulation of innate immune responses to cytosolic DNA; Josephin domain DUBs; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; Formation of TC-NER Pre-Incision Complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Fanconi Anemia Pathway; Autodegradation of the E3 ubiquitin ligase COP1; Negative regulation of MET activity; G2/M Checkpoints; Constitutive Signaling by NOTCH1 PEST Domain Mutants; ER Quality Control Compartment (ERQC); Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of PTEN stability and activity; TICAM1-dependent activation of IRF3/IRF7; Translesion Synthesis by POLH; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Iron uptake and transport; TNFR1-induced NFkappaB signaling pathway; Regulation of PTEN localization; SCF(Skp2)-mediated degradation of p27/p21; Glycogen synthesis; APC/C:Cdc20 mediated degradation of Securin; Translesion synthesis by POLI; IRAK1 recruits IKK complex; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Recognition of DNA damage by PCNA-containing replication complex; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); Translesion synthesis by REV1; Regulation of TP53 Activity through Phosphorylation; The role of GTSE1 in G2/M progression after G2 checkpoint; p75NTR recruits signalling complexes; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Ubiquitin-dependent degradation of Cyclin D1; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of TP53 Degradation; Cyclin D associated events in G1; Regulation of TP53 Activity through Methylation; Orc1 removal from chromatin; M/G1 Transition; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; E3 ubiquitin ligases ubiquitinate target proteins; InlA-mediated entry of Listeria monocytogenes into host cells; Negative regulators of DDX58/IFIH1 signaling; Degradation of beta-catenin by the destruction complex; NF-kB is activated and signals survival; Dual incision in TC-NER; Dectin-1 mediated noncanonical NF-kB signaling; InlB-mediated entry of Listeria monocytogenes into host cell",339,High,1
Q13526,Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 OS=Homo sapiens OX=9606 GN=PIN1 PE=1 SV=1,0,99.516,56,9,147,8,163,18.2,8.82,65826,1.91,9,2,cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;mitochondrion;nucleus,catalytic activity;motor activity;protein binding;transporter activity,"Pf00397, Pf00639, Pf13616",5300,ENSG00000127445.13,PIN1,19,RIG-I-like receptor signaling pathway,RIG-I-like Receptor Signaling,ISG15 antiviral mechanism; PI5P Regulates TP53 Acetylation; Negative regulators of DDX58/IFIH1 signaling; Regulation of TP53 Activity through Phosphorylation,18,High,1
Q969S9,"Ribosome-releasing factor 2, mitochondrial OS=Homo sapiens OX=9606 GN=GFM2 PE=1 SV=1",0,99.345,25,14,87,14,779,86.5,6.51,42047,2.03,14,1,cell organization and biogenesis;metabolic process,mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00009, Pf00679, Pf01926, Pf03144, Pf03764, Pf14492",84340,ENSG00000164347.17,GFM2,5,,,Mitochondrial translation termination,4,High,1
Q5XPI4,E3 ubiquitin-protein ligase RNF123 OS=Homo sapiens OX=9606 GN=RNF123 PE=1 SV=1,0,99.338,18,17,134,17,1314,148.4,6.74,56324,,17,,metabolic process,cytoplasm;cytosol,catalytic activity;metal ion binding;protein binding,"Pf00097, Pf00622, Pf13639, Pf13920, Pf13923, Pf14634",63891,ENSG00000164068.15,RNF123,3,,,Ub-specific processing proteases; Antigen processing: Ubiquitination & Proteasome degradation,8,High,1
Q9UBQ0,Vacuolar protein sorting-associated protein 29 OS=Homo sapiens OX=9606 GN=VPS29 PE=1 SV=1,0,99.291,50,9,161,9,182,20.5,6.79,77376,,9,,regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane,catalytic activity;metal ion binding;protein binding;transporter activity,"Pf00149, Pf12850",51699,ENSG00000111237.18,VPS29,12,Endocytosis,,WNT ligand biogenesis and trafficking,4,High,1
O00148,ATP-dependent RNA helicase DDX39A OS=Homo sapiens OX=9606 GN=DDX39A PE=1 SV=2,0,99.281,27,14,273,2,427,49.1,5.68,128897,0,14,2,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;membrane;nucleus;spliceosomal complex,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00270, Pf00271, Pf14617",10212,ENSG00000123136.14,DDX39A,19,,,Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing,9,High,1
Q86VS8,Protein Hook homolog 3 OS=Homo sapiens OX=9606 GN=HOOK3 PE=1 SV=2,0,99.179,30,19,81,19,718,83.1,5.17,34702,,19,,cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;Golgi,catalytic activity;motor activity;protein binding;transporter activity,"Pf01496, Pf01576, Pf02463, Pf04156, Pf05622, Pf05667, Pf08317, Pf09787, Pf12128, Pf13166",84376,ENSG00000168172.8,HOOK3,8,,,,0,High,1
O95336,6-phosphogluconolactonase OS=Homo sapiens OX=9606 GN=PGLS PE=1 SV=2,0,99.174,65,10,206,10,258,27.5,6.05,88197,,10,,metabolic process,cytoplasm;cytosol,catalytic activity;protein binding,Pf01182,25796,ENSG00000130313.6,PGLS,19,Pentose phosphate pathway; Carbon metabolism; Metabolic pathways,Pentose Phosphate Pathway,Pentose phosphate pathway (hexose monophosphate shunt),7,High,1
Q13425,Beta-2-syntrophin OS=Homo sapiens OX=9606 GN=SNTB2 PE=1 SV=1,0,99.128,35,16,173,15,540,57.9,8.82,79771,0,16,2,,cytoplasm;cytoskeleton;membrane,protein binding;RNA binding;structural molecule activity,"Pf00169, Pf00595, Pf13180",6645,ENSG00000168807.16,SNTB2,16,,,,0,High,1
Q9Y6C2,EMILIN-1 OS=Homo sapiens OX=9606 GN=EMILIN1 PE=1 SV=3,0,99.115,20,14,89,14,1016,106.6,5.17,41005,,14,,cell organization and biogenesis;cellular component movement,extracellular,protein binding;structural molecule activity,"Pf00386, Pf07546",11117,ENSG00000138080.13,EMILIN1,2,,,,0,High,1
Q15424,Scaffold attachment factor B1 OS=Homo sapiens OX=9606 GN=SAFB PE=1 SV=4,0,99.083,21,13,66,7,915,102.6,5.47,29567,4.45,12,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,nucleus,DNA binding;protein binding;RNA binding,"Pf00076, Pf02037, Pf13893, Pf14259",6294,ENSG00000160633.12,SAFB,19,,Structural Pathway of Interleukin 1 (IL-1),,1,High,1
P21589,5'-nucleotidase OS=Homo sapiens OX=9606 GN=NT5E PE=1 SV=1,0,99.051,40,16,102,16,574,63.3,7.03,37456,,16,,metabolic process;regulation of biological process,cell surface;cytosol;membrane,catalytic activity;metal ion binding;nucleotide binding,"Pf00149, Pf02872, Pf09587",4907,ENSG00000135318.11,NT5E,6,Pyrimidine metabolism; Nicotinate and nicotinamide metabolism; Metabolic pathways; Purine metabolism,Differentiation Pathway; NAD+ metabolism,Pyrimidine catabolism; Purine catabolism; Nicotinate metabolism,14,High,1
Q96A33,Coiled-coil domain-containing protein 47 OS=Homo sapiens OX=9606 GN=CCDC47 PE=1 SV=1,0,98.975,30,13,109,13,483,55.8,4.87,46270,,13,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;membrane,metal ion binding;protein binding;RNA binding,Pf07946,57003,ENSG00000108588.13,CCDC47,17,,,,0,High,1
P16403,Histone H1.2 OS=Homo sapiens OX=9606 GN=H1-2 PE=1 SV=2,0,98.858,25,14,556,5,213,21.4,10.93,305026,3.01,14,3,cell organization and biogenesis;metabolic process;regulation of biological process,chromosome;nucleus,DNA binding;protein binding;RNA binding,Pf00538,3006,ENSG00000187837.3,HIST1H1C,6,,,Formation of Senescence-Associated Heterochromatin Foci (SAHF); Activation of DNA fragmentation factor,10,High,1
P62993,Growth factor receptor-bound protein 2 OS=Homo sapiens OX=9606 GN=GRB2 PE=1 SV=1,0,98.818,50,13,138,13,217,25.2,6.32,68785,,13,,cell communication;cell differentiation;cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;Golgi;membrane;nucleus,catalytic activity;protein binding;RNA binding,"Pf00017, Pf00018, Pf07653, Pf14604",2885,ENSG00000177885.13,GRB2,17,Prolactin signaling pathway; Breast cancer; Proteoglycans in cancer; Estrogen signaling pathway; Hepatitis B; Non-small cell lung cancer; EGFR tyrosine kinase inhibitor resistance; GnRH signaling pathway; T cell receptor signaling pathway; Neurotrophin signaling pathway; Glioma; Alcoholism; MicroRNAs in cancer; ErbB signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Insulin signaling pathway; Endometrial cancer; Jak-STAT signaling pathway; Chemokine signaling pathway; Dorso-ventral axis formation; Acute myeloid leukemia; Renal cell carcinoma; Ras signaling pathway; Chronic myeloid leukemia; Prostate cancer; Fc epsilon RI signaling pathway; Natural killer cell mediated cytotoxicity; MAPK signaling pathway; B cell receptor signaling pathway; Phospholipase D signaling pathway; FoxO signaling pathway; Signaling pathways regulating pluripotency of stem cells; Osteoclast differentiation; Endocrine resistance; Viral carcinogenesis; Hepatitis C; Choline metabolism in cancer; Focal adhesion; Gap junction; Pathways in cancer,IL-5 Signaling Pathway; Integrin-mediated Cell Adhesion; Leptin signaling pathway; Prolactin Signaling Pathway; IL-9 Signaling Pathway; Signaling Pathways in Glioblastoma; B Cell Receptor Signaling Pathway; TNF alpha Signaling Pathway; Interleukin-11 Signaling Pathway; Oncostatin M Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Alpha 6 Beta 4 signaling pathway; IL-3 Signaling Pathway; Kit receptor signaling pathway; Focal Adhesion; Signaling of Hepatocyte Growth Factor Receptor; Rac1/Pak1/p38/MMP-2 pathway; IL-6 signaling pathway; Hepatitis C and Hepatocellular Carcinoma; TGF-beta Signaling Pathway; BDNF-TrkB Signaling; Association Between Physico-Chemical Features and Toxicity Associated Pathways; MAPK Signaling Pathway; T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 Signaling Pathway; Chemokine signaling pathway; ESC Pluripotency Pathways; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; IL-4 Signaling Pathway; p38 MAPK Signaling Pathway; EGF/EGFR Signaling Pathway; Insulin Signaling; IL-2 Signaling Pathway; EPO Receptor Signaling; ErbB Signaling Pathway; T-Cell antigen Receptor (TCR)  Signaling Pathway; DNA Damage Response (only ATM dependent),"PI3K Cascade; SHC-mediated cascade:FGFR4; Signaling by FGFR4 in disease; PI-3K cascade:FGFR3; FRS-mediated FGFR4 signaling; Signal regulatory protein family interactions; EGFR downregulation; SHC1 events in ERBB4 signaling; NCAM signaling for neurite out-growth; DAP12 signaling; PI-3K cascade:FGFR4; GRB2 events in EGFR signaling; Regulation of signaling by CBL; Regulation of actin dynamics for phagocytic cup formation; Signaling by cytosolic FGFR1 fusion mutants; MET activates PI3K/AKT signaling; Constitutive Signaling by EGFRvIII; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Interleukin receptor SHC signaling; MET receptor recycling; FRS-mediated FGFR3 signaling; SHC-mediated cascade:FGFR3; Negative regulation of MET activity; FRS-mediated FGFR2 signaling; CD28 dependent Vav1 pathway; Signalling to RAS; GPVI-mediated activation cascade; FRS-mediated FGFR1 signaling; PI-3K cascade:FGFR2; RET signaling; SHC-mediated cascade:FGFR1; GRB2 events in ERBB2 signaling; PI-3K cascade:FGFR1; PI3K events in ERBB2 signaling; Role of LAT2/NTAL/LAB on calcium mobilization; RAF/MAP kinase cascade; Tie2 Signaling; FCERI mediated Ca+2 mobilization; SHC1 events in ERBB2 signaling; SHC-related events triggered by IGF1R; Signaling by FGFR2 in disease; FCERI mediated MAPK activation; Signaling by FGFR3 fusions in cancer; G beta:gamma signalling through PI3Kgamma; MET activates RAP1 and RAC1; Downstream signal transduction; Signaling by FGFR3 point mutants in cancer; MET activates RAS signaling; MET activates PTPN11; Signal attenuation; SHC-mediated cascade:FGFR2; EGFR Transactivation by Gastrin; Constitutive Signaling by Aberrant PI3K in Cancer; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; SOS-mediated signalling; Interleukin-20 family signaling; Interleukin-15 signaling; Spry regulation of FGF signaling; Cargo recognition for clathrin-mediated endocytosis; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; SHC1 events in EGFR signaling; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; RHO GTPases Activate WASPs and WAVEs; Regulation of KIT signaling; GAB1 signalosome; InlB-mediated entry of Listeria monocytogenes into host cell",223,High,1
Q15813,Tubulin-specific chaperone E OS=Homo sapiens OX=9606 GN=TBCE PE=1 SV=1,0,98.816,44,16,75,16,527,59.3,6.76,30859,,16,,cell organization and biogenesis;metabolic process;response to stimulus,cytoplasm;cytoskeleton,protein binding,"Pf01302, Pf12799, Pf13855, Pf14560, Pf14580",6905,ENSG00000282984.1; ENSG00000116957.12,TBCE,1; CHR_HSCHR1_5_CTG32_1,,,Post-chaperonin tubulin folding pathway,3,High,1
Q9BUP0,EF-hand domain-containing protein D1 OS=Homo sapiens OX=9606 GN=EFHD1 PE=1 SV=1,0,98.795,50,13,113,10,239,26.9,5.39,58217,0,13,1,cell organization and biogenesis,membrane;mitochondrion,metal ion binding,Pf13499,80303,ENSG00000115468.11,EFHD1,2,,,,0,High,1
Q9NRV9,Heme-binding protein 1 OS=Homo sapiens OX=9606 GN=HEBP1 PE=1 SV=1,0,98.645,60,9,128,9,189,21.1,5.8,62716,6.11,9,1,regulation of biological process;response to stimulus,cytoplasm;extracellular,,Pf04832,50865,ENSG00000013583.8,HEBP1,12,,,Formyl peptide receptors bind formyl peptides and many other ligands; G alpha (i) signalling events,8,High,1
P49137,MAP kinase-activated protein kinase 2 OS=Homo sapiens OX=9606 GN=MAPKAPK2 PE=1 SV=1,0,98.605,39,14,197,10,400,45.5,8.68,87446,0,14,2,defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus,catalytic activity;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf07714, Pf14531",9261,ENSG00000162889.10,MAPKAPK2,1,MAPK signaling pathway; Neurotrophin signaling pathway; VEGF signaling pathway; Viral carcinogenesis,IL-1 signaling pathway; Regulation of Microtubule Cytoskeleton; Structural Pathway of Interleukin 1 (IL-1); Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation; MAPK Signaling Pathway; VEGFA-VEGFR2 Signaling Pathway; p38 MAPK Signaling Pathway; Serotonin Receptor 2 and ELK-SRF/GATA4 signaling; Serotonin Receptor 4/6/7 and NR3C Signaling,"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Activated TLR4 signalling; activated TAK1 mediates p38 MAPK activation; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; CREB phosphorylation; Regulation of HSF1-mediated heat shock response; p38MAPK events; VEGFA-VEGFR2 Pathway; Synthesis of Leukotrienes (LT) and Eoxins (EX); Oxidative Stress Induced Senescence",64,High,1
O95487,Protein transport protein Sec24B OS=Homo sapiens OX=9606 GN=SEC24B PE=1 SV=2,0,98.538,14,14,97,12,1268,137.3,6.67,39480,,14,,cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytosol;endoplasmic reticulum;membrane,metal ion binding;protein binding,"Pf00626, Pf04810, Pf04811, Pf04815, Pf08033",10427,ENSG00000138802.11,SEC24B,4,Protein processing in endoplasmic reticulum,Sterol Regulatory Element-Binding Proteins (SREBP) signalling,"Regulation of cholesterol biosynthesis by SREBP (SREBF); Cargo concentration in the ER; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; COPII (Coat Protein 2) Mediated Vesicle Transport; MHC class II antigen presentation",20,High,1
Q00688,Peptidyl-prolyl cis-trans isomerase FKBP3 OS=Homo sapiens OX=9606 GN=FKBP3 PE=1 SV=1,0,98.511,35,8,192,8,224,25.2,9.28,97478,0,8,1,metabolic process,cytoplasm;nucleus,catalytic activity;protein binding;receptor activity;RNA binding,Pf00254,2287,ENSG00000100442.10,FKBP3,14,,,,0,High,1
P30419,Glycylpeptide N-tetradecanoyltransferase 1 OS=Homo sapiens OX=9606 GN=NMT1 PE=1 SV=2,0,98.505,29,13,95,9,496,56.8,7.8,39163,,13,,metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;mitochondrion,catalytic activity,"Pf01233, Pf02799",4836,ENSG00000136448.11,NMT1,17,,,"Signaling by GPCR; Activation, myristolyation of BID and translocation to mitochondria; Late Phase of HIV Life Cycle; Inactivation, recovery and regulation of the phototransduction cascade",14,High,1
Q96C86,m7GpppX diphosphatase OS=Homo sapiens OX=9606 GN=DCPS PE=1 SV=2,0,98.425,41,12,116,12,337,38.6,6.38,56783,,12,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;mitochondrion;nucleus,catalytic activity;protein binding;RNA binding,"Pf05652, Pf11969",28960,ENSG00000110063.8,DCPS,11,RNA degradation,,mRNA decay by 3' to 5' exoribonuclease,4,High,1
Q9NVH6,"Trimethyllysine dioxygenase, mitochondrial OS=Homo sapiens OX=9606 GN=TMLHE PE=1 SV=1",0,98.322,31,11,329,11,421,49.5,7.72,155144,14.51,10,5,metabolic process;regulation of biological process,mitochondrion;organelle lumen,catalytic activity;metal ion binding,Pf02668,55217,ENSG00000185973.10,TMLHE,X,Lysine degradation,,Carnitine synthesis,5,High,1
Q9Y5K5-3,Isoform 3 of Ubiquitin carboxyl-terminal hydrolase isozyme L5 OS=Homo sapiens OX=9606 GN=UCHL5,0,98.249,50,14,138,14,328,37.5,5.4,61033,3.16,13,1,metabolic process;regulation of biological process;response to stimulus,cytosol;mitochondrion;nucleus;proteasome,catalytic activity;enzyme regulator activity;protein binding;RNA binding,Pf01088,51377,ENSG00000116750.13,UCHL5,1,,TGF-beta Signaling Pathway,,1,High,1
Q9UBW8,COP9 signalosome complex subunit 7a OS=Homo sapiens OX=9606 GN=COPS7A PE=1 SV=1,0,98.099,45,11,146,11,275,30.3,8.22,69137,,11,,cell organization and biogenesis;metabolic process;response to stimulus,cytoplasm;cytosol;nucleus,protein binding,Pf01399,50813,ENSG00000111652.9,COPS7A,12,,,Cargo recognition for clathrin-mediated endocytosis; DNA Damage Recognition in GG-NER; Formation of TC-NER Pre-Incision Complex; Neddylation,13,High,1
O00471,Exocyst complex component 5 OS=Homo sapiens OX=9606 GN=EXOC5 PE=1 SV=1,0,98.033,30,16,75,16,708,81.8,6.71,34083,,16,,transport,cytoplasm;cytosol,protein binding,"Pf03938, Pf07393",10640,ENSG00000070367.15,EXOC5,14,,,Translocation of GLUT4 to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium,10,High,1
Q13363,C-terminal-binding protein 1 OS=Homo sapiens OX=9606 GN=CTBP1 PE=1 SV=2,0,98.001,37,14,165,12,440,47.5,6.77,72110,0,14,1,cell differentiation;metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00389, Pf02826",1487,ENSG00000159692.15,CTBP1,4,Pathways in cancer; Notch signaling pathway; Chronic myeloid leukemia; Wnt signaling pathway,Notch Signaling Pathway; Ectoderm Differentiation; Wnt Signaling Pathway Netpath; Pathways Affected in Adenoid Cystic Carcinoma; Wnt Signaling Pathway and Pluripotency,Repression of WNT target genes; Deactivation of the beta-catenin transactivating complex; TCF7L2 mutants don't bind CTBP,19,High,1
Q8N183,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 OS=Homo sapiens OX=9606 GN=NDUFAF2 PE=1 SV=1,0,97.975,62,12,169,12,169,19.8,8.97,72785,16.22,12,1,cell organization and biogenesis;metabolic process;regulation of biological process,membrane;mitochondrion,catalytic activity,Pf05071,91942,ENSG00000164182.10,NDUFAF2,5,,,Complex I biogenesis,5,High,1
Q9NZL9,Methionine adenosyltransferase 2 subunit beta OS=Homo sapiens OX=9606 GN=MAT2B PE=1 SV=1,0,97.881,37,13,158,13,334,37.5,7.36,79505,,13,,metabolic process;regulation of biological process,cytosol;mitochondrion;nucleus,catalytic activity;enzyme regulator activity;protein binding,"Pf00106, Pf01073, Pf01370, Pf02719, Pf04321, Pf07993, Pf13460",27430,ENSG00000038274.16,MAT2B,5,Cysteine and methionine metabolism; Metabolic pathways; Biosynthesis of amino acids,Trans-sulfuration pathway; One Carbon Metabolism; Trans-sulfuration and one carbon metabolism; Methylation Pathways,Ub-specific processing proteases; Methylation,15,High,1
Q2V2M9-4,Isoform 4 of FH1/FH2 domain-containing protein 3 OS=Homo sapiens OX=9606 GN=FHOD3,0,97.646,17,16,57,16,1622,180,5.53,10666,73.05,5,12,cell organization and biogenesis;regulation of biological process,,protein binding,Pf02181,80206,ENSG00000134775.15,FHOD3,18,,,,0,High,1
Q6UWE0,E3 ubiquitin-protein ligase LRSAM1 OS=Homo sapiens OX=9606 GN=LRSAM1 PE=1 SV=1,0,97.574,28,16,67,16,723,83.5,5.94,25793,,16,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane,catalytic activity;metal ion binding;protein binding;transporter activity,"Pf00536, Pf07647, Pf12799, Pf13855, Pf13920",90678,ENSG00000148356.13,LRSAM1,9,,,Antigen processing: Ubiquitination & Proteasome degradation,4,High,1
P55263,Adenosine kinase OS=Homo sapiens OX=9606 GN=ADK PE=1 SV=2,0,97.565,35,11,140,11,362,40.5,6.7,62227,1.71,11,1,metabolic process,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;nucleotide binding;RNA binding,Pf00294,132,ENSG00000156110.13,ADK,10,Metabolic pathways; Purine metabolism,,Purine salvage,6,High,1
Q14192,Four and a half LIM domains protein 2 OS=Homo sapiens OX=9606 GN=FHL2 PE=1 SV=3,0,97.564,40,14,1423,14,279,32.2,7.55,760760,81.66,9,6,cell differentiation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,metal ion binding;protein binding,Pf00412,2274,ENSG00000115641.18,FHL2,2,Osteoclast differentiation,Androgen receptor signaling pathway; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; Ectoderm Differentiation; VEGFA-VEGFR2 Signaling Pathway,PPARA activates gene expression,9,High,1
Q6IAA8,Ragulator complex protein LAMTOR1 OS=Homo sapiens OX=9606 GN=LAMTOR1 PE=1 SV=2,0,97.55,65,7,207,7,161,17.7,5.15,107228,0,7,1,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,endosome;membrane;vacuole,protein binding;structural molecule activity,Pf15454,55004,ENSG00000149357.9,LAMTOR1,11,mTOR signaling pathway,,Energy dependent regulation of mTOR by LKB1-AMPK; Neutrophil degranulation; Regulation of PTEN gene transcription; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Macroautophagy,19,High,1
Q6YP21,Kynurenine--oxoglutarate transaminase 3 OS=Homo sapiens OX=9606 GN=KYAT3 PE=1 SV=1,0,97.309,33,13,140,13,454,51.4,8.19,56448,1.9,13,1,metabolic process,mitochondrion,catalytic activity;protein binding;RNA binding,"Pf00155, Pf00266, Pf01041, Pf01053",56267,ENSG00000137944.17,CCBL2; KYAT3,1,Chemical carcinogenesis; Tryptophan metabolism; Selenocompound metabolism; Metabolic pathways,,Tryptophan catabolism,8,High,1
O15254,Peroxisomal acyl-coenzyme A oxidase 3 OS=Homo sapiens OX=9606 GN=ACOX3 PE=1 SV=2,0,97.237,30,15,81,15,700,77.6,7.25,35989,0,15,2,metabolic process,membrane;mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding,"Pf00441, Pf01756, Pf02770, Pf14749",8310,ENSG00000087008.15,ACOX3,4,cAMP signaling pathway; PPAR signaling pathway; alpha-Linolenic acid metabolism; Peroxisome; Fatty acid metabolism; Metabolic pathways; Biosynthesis of unsaturated fatty acids; Fatty acid degradation,PPAR signaling pathway,Beta-oxidation of pristanoyl-CoA,14,High,1
P00740,Coagulation factor IX OS=Homo sapiens OX=9606 GN=F9 PE=1 SV=2,0,97.111,17,10,520,8,461,51.7,5.47,243776,,10,,coagulation;metabolic process;response to stimulus;transport,extracellular;membrane;organelle lumen,catalytic activity;metal ion binding;protein binding,"Pf00008, Pf00089, Pf00594, Pf13365, Pf14670",2158,ENSG00000101981.10,F9,X,Complement and coagulation cascades,Blood Clotting Cascade; Complement and Coagulation Cascades,Extrinsic Pathway of Fibrin Clot Formation; Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus; Intrinsic Pathway of Fibrin Clot Formation; Removal of aminoterminal propeptides from gamma-carboxylated proteins; Gamma-carboxylation of protein precursors,14,High,1
P05164,Myeloperoxidase OS=Homo sapiens OX=9606 GN=MPO PE=1 SV=1,0,97.102,30,18,92,18,745,83.8,8.97,41271,,18,,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;mitochondrion;nucleus;organelle lumen;vacuole,antioxidant activity;catalytic activity;metal ion binding,Pf03098,4353,ENSG00000005381.7,MPO,17,Phagosome; Transcriptional misregulation in cancer,Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism; Benzene metabolism,Neutrophil degranulation,9,High,1
Q5VZP5,Inactive dual specificity phosphatase 27 OS=Homo sapiens OX=9606 GN=DUSP27 PE=2 SV=1,0,97.095,23,15,58,15,1158,130.1,5.17,7849,78.45,5,11,metabolic process,cytoplasm,catalytic activity,Pf00782,92235,ENSG00000198842.9,DUSP27,1,,,,0,High,1
Q5JTZ9,"Alanine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=AARS2 PE=1 SV=1",0,97.058,21,19,107,19,985,107.3,6.27,49866,,19,,cell organization and biogenesis;metabolic process,cytoplasm;mitochondrion,catalytic activity;metal ion binding;nucleotide binding;RNA binding,"Pf01411, Pf07973",57505,ENSG00000124608.4,AARS2,6,Aminoacyl-tRNA biosynthesis,,Mitochondrial tRNA aminoacylation,5,High,1
O15239,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 OS=Homo sapiens OX=9606 GN=NDUFA1 PE=1 SV=1,0,96.988,39,8,588,8,70,8.1,8.84,246381,8.93,7,2,cell organization and biogenesis;metabolic process;transport,cytosol;membrane;mitochondrion,catalytic activity,,4694,ENSG00000125356.6,NDUFA1,X,Huntington's disease; Metabolic pathways; Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Parkinson's disease,Electron Transport Chain,Complex I biogenesis,12,High,1
O75821,Eukaryotic translation initiation factor 3 subunit G OS=Homo sapiens OX=9606 GN=EIF3G PE=1 SV=2,0,96.92,58,13,94,13,320,35.6,6.13,42614,1.83,12,1,metabolic process,cytoplasm;cytosol;nucleus,protein binding;RNA binding,"Pf00076, Pf12353, Pf13893, Pf14259",8666,ENSG00000130811.11,EIF3G,19,RNA transport,Translation Factors,"Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Ribosomal scanning and start codon recognition",13,High,1
Q92599,Septin-8 OS=Homo sapiens OX=9606 GN=SEPTIN8 PE=1 SV=4,0,96.86,29,13,208,9,483,55.7,6.28,106015,0,13,2,,cytoplasm;cytoskeleton,nucleotide binding;protein binding,Pf00735,23176,ENSG00000164402.13,SEPT8,5,Bacterial invasion of epithelial cells,,,1,High,1
Q08623,Pseudouridine-5'-phosphatase OS=Homo sapiens OX=9606 GN=PUDP PE=1 SV=3,0,96.847,54,10,153,10,228,25.2,5.31,61409,0,10,1,metabolic process,cytoplasm;cytosol,catalytic activity;metal ion binding,"Pf00702, Pf13242, Pf13419",8226,ENSG00000130021.13,HDHD1; PUDP,X,,,Pyrimidine salvage,4,High,1
P49902,Cytosolic purine 5'-nucleotidase OS=Homo sapiens OX=9606 GN=NT5C2 PE=1 SV=1,0,96.79,30,12,114,12,561,64.9,6.14,51309,,12,,metabolic process,cytoplasm;cytosol,catalytic activity;metal ion binding;nucleotide binding;protein binding,Pf05761,22978,ENSG00000076685.18,NT5C2,10,Pyrimidine metabolism; Nicotinate and nicotinamide metabolism; Metabolic pathways; Purine metabolism,,Abacavir metabolism; Purine catabolism,10,High,1
P62917,60S ribosomal protein L8 OS=Homo sapiens OX=9606 GN=RPL8 PE=1 SV=2,0,96.711,30,9,356,9,257,28,11.03,153388,0,9,1,cell organization and biogenesis;metabolic process;response to stimulus;transport,cytoplasm;cytosol;membrane;ribosome,RNA binding;structural molecule activity,"Pf00181, Pf03947",6132,ENSG00000161016.17,RPL8,8,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
P61026,Ras-related protein Rab-10 OS=Homo sapiens OX=9606 GN=RAB10 PE=1 SV=1,0,96.585,52,12,322,10,200,22.5,8.38,162742,,12,,cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytosol;endoplasmic reticulum;endosome;Golgi;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf04670, Pf08477",10890,ENSG00000084733.10,RAB10,2,Endocytosis; AMPK signaling pathway,Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,Translocation of GLUT4 to the plasma membrane; Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation,14,High,1
O94903,Pyridoxal phosphate homeostasis protein OS=Homo sapiens OX=9606 GN=PLPBP PE=1 SV=1,0,96.565,43,10,241,10,275,30.3,7.5,107431,2.04,10,2,,cytoplasm;mitochondrion,,Pf01168,11212,ENSG00000147471.11,PROSC; PLPBP,8,,,,0,High,1
P56134,"ATP synthase subunit f, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5MF PE=1 SV=3",0,96.519,53,9,1044,2,94,10.9,9.67,510940,32.62,7,4,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion;nucleus,catalytic activity;transporter activity,Pf10206,9551,ENSG00000241468.7,ATP5J2,7,Oxidative phosphorylation; Metabolic pathways,Electron Transport Chain; Oxidative phosphorylation,Cristae formation; Formation of ATP by chemiosmotic coupling,11,High,1
Q8IYI6,Exocyst complex component 8 OS=Homo sapiens OX=9606 GN=EXOC8 PE=1 SV=2,0,96.509,33,16,73,16,725,81.7,5.49,30251,6.77,15,1,cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytosol;endosome;membrane,protein binding,"Pf00169, Pf08700",149371,ENSG00000116903.7,EXOC8,1,,RalA downstream regulated genes,Translocation of GLUT4 to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium,11,High,1
Q99873,Protein arginine N-methyltransferase 1 OS=Homo sapiens OX=9606 GN=PRMT1 PE=1 SV=3,0,96.486,38,12,119,12,371,42.4,5.35,61255,,12,,,,,,,,,,,,,0,High,1
P26368,Splicing factor U2AF 65 kDa subunit OS=Homo sapiens OX=9606 GN=U2AF2 PE=1 SV=4,0,96.43,37,9,97,9,475,53.5,9.09,49051,0,9,1,metabolic process;regulation of biological process;transport,nucleus;spliceosomal complex,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",11338,ENSG00000063244.12,U2AF2,19,Spliceosome,mRNA Processing,Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway,13,High,1
P19971,Thymidine phosphorylase OS=Homo sapiens OX=9606 GN=TYMP PE=1 SV=2,0,96.409,35,12,75,12,482,49.9,5.53,37431,,12,,cell differentiation;cell organization and biogenesis;cellular homeostasis;development;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;membrane;mitochondrion;organelle lumen,catalytic activity;metal ion binding;protein binding,"Pf00591, Pf02885, Pf07831",1890; 9997,ENSG00000025708.13,TYMP; SCO2,22,Metabolic pathways; Drug metabolism - other enzymes; Bladder cancer; Pyrimidine metabolism,Fluoropyrimidine Activity; Bladder Cancer,Pyrimidine salvage; Pyrimidine catabolism,12,High,1
O00165,HCLS1-associated protein X-1 OS=Homo sapiens OX=9606 GN=HAX1 PE=1 SV=2,0,96.393,62,11,110,11,279,31.6,4.92,54309,,11,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;endoplasmic reticulum;membrane;mitochondrion;nucleus,protein binding,,10456,ENSG00000143575.14,HAX1,1,,,,0,High,1
Q86XP3,ATP-dependent RNA helicase DDX42 OS=Homo sapiens OX=9606 GN=DDX42 PE=1 SV=1,0,96.373,23,17,84,17,938,102.9,7.02,33185,0,17,3,metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00270, Pf00271, Pf13307",11325,ENSG00000198231.12,DDX42,17,Spliceosome,,mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway,6,High,1
P49915,GMP synthase [glutamine-hydrolyzing] OS=Homo sapiens OX=9606 GN=GMPS PE=1 SV=1,0,96.35,32,14,87,14,693,76.7,6.87,38463,,14,,metabolic process,cytoplasm;cytosol,catalytic activity;nucleotide binding,"Pf00117, Pf00733, Pf00958, Pf01171, Pf02540, Pf03054, Pf06508, Pf07722",8833,ENSG00000163655.15,GMPS,3,Purine metabolism; Drug metabolism - other enzymes; Metabolic pathways,,Purine ribonucleoside monophosphate biosynthesis,7,High,1
Q13464,Rho-associated protein kinase 1 OS=Homo sapiens OX=9606 GN=ROCK1 PE=1 SV=1,0,96.324,18,21,82,18,1354,158.1,5.9,33852,,21,,cell death;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;extracellular;Golgi;membrane;organelle lumen,catalytic activity;metal ion binding;motor activity;nucleotide binding;protein binding,"Pf00069, Pf00130, Pf00169, Pf00433, Pf01576, Pf02463, Pf03962, Pf04111, Pf04156, Pf05557, Pf05622, Pf06160, Pf07714, Pf07888, Pf08912, Pf09726, Pf09789, Pf10174, Pf12128, Pf12795, Pf14531, Pf14915, Pf15619",6093,ENSG00000067900.7,ROCK1,18,Chemokine signaling pathway; Salmonella infection; cGMP-PKG signaling pathway; TGF-beta signaling pathway; Platelet activation; Leukocyte transendothelial migration; Focal adhesion; Pathogenic Escherichia coli infection; Axon guidance; Oxytocin signaling pathway; Sphingolipid signaling pathway; MicroRNAs in cancer; Regulation of actin cytoskeleton; Vascular smooth muscle contraction; Shigellosis; Proteoglycans in cancer; cAMP signaling pathway; Pathways in cancer,Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated Cell Adhesion; Leptin signaling pathway; Regulation of Microtubule Cytoskeleton; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Focal Adhesion; TGF-beta Signaling Pathway; VEGFA-VEGFR2 Signaling Pathway; Chemokine signaling pathway; EGF/EGFR Signaling Pathway; Regulation of Actin Cytoskeleton; G13 Signaling Pathway,EPHA-mediated growth cone collapse; G alpha (12/13) signalling events; EPHB-mediated forward signaling; RHO GTPases Activate ROCKs; Neutrophil degranulation; Sema4D induced cell migration and growth-cone collapse; Apoptotic cleavage of cellular proteins; VEGFA-VEGFR2 Pathway,57,High,1
Q16539,Mitogen-activated protein kinase 14 OS=Homo sapiens OX=9606 GN=MAPK14 PE=1 SV=3,0,96.284,50,14,205,13,360,41.3,5.78,97823,,14,,cell death;cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;mitochondrion;nucleus;organelle lumen,catalytic activity;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf01636, Pf07714",1432,ENSG00000112062.10,MAPK14,6,FoxO signaling pathway; Hepatitis C; Proteoglycans in cancer; Leishmaniasis; T cell receptor signaling pathway; Signaling pathways regulating pluripotency of stem cells; Toll-like receptor signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Prolactin signaling pathway; Endocrine resistance; Salmonella infection; Rap1 signaling pathway; TNF signaling pathway; Influenza A; Fc epsilon RI signaling pathway; Tuberculosis; Epstein-Barr virus infection; Dopaminergic synapse; RIG-I-like receptor signaling pathway; Retrograde endocannabinoid signaling; Progesterone-mediated oocyte maturation; NOD-like receptor signaling pathway; Platelet activation; Inflammatory mediator regulation of TRP channels; Pertussis; Neurotrophin signaling pathway; Chagas disease (American trypanosomiasis); GnRH signaling pathway; Leukocyte transendothelial migration; MAPK signaling pathway; Osteoclast differentiation; Shigellosis; Amyotrophic lateral sclerosis (ALS); Toxoplasmosis; VEGF signaling pathway; Th1 and Th2 cell differentiation; Epithelial cell signaling in Helicobacter pylori infection; Sphingolipid signaling pathway; Adrenergic signaling in cardiomyocytes,Regulation of toll-like receptor signaling pathway; Physiological and Pathological Hypertrophy  of the Heart; Angiogenesis; Energy Metabolism; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; Human Thyroid Stimulating Hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle Stimulating Hormone (FSH) signaling pathway; TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway; Prolactin Signaling Pathway; B Cell Receptor Signaling Pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Parkinsons Disease Pathway; Oncostatin M Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Cardiac Progenitor Differentiation; Alpha 6 Beta 4 signaling pathway; Amyotrophic lateral sclerosis (ALS); Structural Pathway of Interleukin 1 (IL-1); Cardiac Hypertrophic Response; Kit receptor signaling pathway; Rac1/Pak1/p38/MMP-2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Hepatitis C and Hepatocellular Carcinoma; TGF-beta Signaling Pathway; Hypothesized Pathways in Pathogenesis of Cardiovascular Disease; MAPK Signaling Pathway; RIG-I-like Receptor Signaling; Canonical and Non-Canonical TGF-B signaling; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; IL-4 Signaling Pathway; p38 MAPK Signaling Pathway; Oxidative Stress; MAPK Cascade; EGF/EGFR Signaling Pathway; Insulin Signaling; Interferon type I signaling pathways; Senescence and Autophagy in Cancer; T-Cell antigen Receptor (TCR)  Signaling Pathway; Estrogen signaling pathway; Monoamine Transport; Toll-like receptor signaling pathway,NOD1/2 Signaling Pathway; ERK/MAPK targets; ADP signalling through P2Y purinoceptor 1; KSRP (KHSRP) binds and destabilizes mRNA; Platelet sensitization by LDL; Activated TLR4 signalling; CDO in myogenesis; Neutrophil degranulation; activated TAK1 mediates p38 MAPK activation; Activation of the AP-1 family of transcription factors; Regulation of TP53 Activity through Phosphorylation; p38MAPK events; VEGFA-VEGFR2 Pathway; DSCAM interactions; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Oxidative Stress Induced Senescence,153,High,1
O95363,"Phenylalanine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=FARS2 PE=1 SV=1",0,96.201,39,13,115,13,451,52.3,7.46,46639,1.72,12,1,metabolic process,cytoplasm;mitochondrion;organelle lumen,catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding,"Pf01409, Pf03147",10667,ENSG00000145982.11,FARS2,6,Aminoacyl-tRNA biosynthesis,,Mitochondrial tRNA aminoacylation,5,High,1
Q9H0B6,Kinesin light chain 2 OS=Homo sapiens OX=9606 GN=KLC2 PE=1 SV=1,0,96.084,23,10,102,4,622,68.9,7.15,52575,,10,,cellular component movement;transport,cytoplasm;cytoskeleton;cytosol;membrane,catalytic activity;motor activity;protein binding,"Pf00515, Pf09311, Pf11068, Pf12895, Pf13374, Pf13414, Pf13424, Pf13432",64837,ENSG00000174996.11,KLC2,11,Salmonella infection,,COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; RHO GTPases activate KTN1; MHC class II antigen presentation,16,High,1
Q9H270,Vacuolar protein sorting-associated protein 11 homolog OS=Homo sapiens OX=9606 GN=VPS11 PE=1 SV=1,0,96.077,26,17,92,17,941,107.8,7.05,34821,2.46,16,2,cell organization and biogenesis;metabolic process;regulation of biological process;transport,endosome;membrane;vacuole,metal ion binding;nucleotide binding;protein binding,"Pf00097, Pf00637, Pf12451, Pf12678, Pf13639, Pf13923, Pf14634, Pf15227",55823,,VPS11,11,,,,0,High,1
O95352,Ubiquitin-like modifier-activating enzyme ATG7 OS=Homo sapiens OX=9606 GN=ATG7 PE=1 SV=1,0,96.073,27,17,86,17,703,77.9,6.24,37571,,17,,cell communication;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;organelle lumen,catalytic activity;protein binding,Pf00899,10533,ENSG00000197548.12,ATG7,3,Autophagy,Nanoparticle triggered autophagic cell death; Senescence and Autophagy in Cancer,Signaling by BRAF and RAF fusions; Neutrophil degranulation; Macroautophagy; Antigen processing: Ubiquitination & Proteasome degradation,15,High,1
P57737-3,Isoform 3 of Coronin-7 OS=Homo sapiens OX=9606 GN=CORO7,0,96.033,22,14,95,14,1048,114.1,6.33,41530,0,14,1,cell organization and biogenesis;transport,cytosol;Golgi;membrane,protein binding,"Pf00400, Pf03656, Pf08953, Pf08954",100529144; 79585,ENSG00000103426.12; ENSG00000278760.4,CORO7-PAM16; CORO7,16; CHR_HSCHR16_3_CTG1,,,,0,High,1
P07919,"Cytochrome b-c1 complex subunit 6, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRH PE=1 SV=2",0,95.987,48,5,140,5,91,10.7,4.44,67494,11.16,4,1,metabolic process;transport,membrane;mitochondrion,catalytic activity;protein binding;transporter activity,Pf02320,7388,ENSG00000173660.11,UQCRH,1,Metabolic pathways; Parkinson's disease; Oxidative phosphorylation; Cardiac muscle contraction; Non-alcoholic fatty liver disease (NAFLD); Alzheimer's disease; Huntington's disease,Electron Transport Chain,Respiratory electron transport,12,High,1
P50402,Emerin OS=Homo sapiens OX=9606 GN=EMD PE=1 SV=1,0,95.955,49,11,152,11,254,29,5.5,73272,,11,,cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;endoplasmic reticulum;membrane;nucleus,protein binding,Pf03020,2010,ENSG00000102119.10,EMD,X,Dilated cardiomyopathy; Hypertrophic cardiomyopathy (HCM); Arrhythmogenic right ventricular cardiomyopathy (ARVC),Arrhythmogenic Right Ventricular Cardiomyopathy,Depolymerisation of the Nuclear Lamina; Initiation of Nuclear Envelope Reformation; Clearance of Nuclear Envelope Membranes from Chromatin,15,High,1
P55039,Developmentally-regulated GTP-binding protein 2 OS=Homo sapiens OX=9606 GN=DRG2 PE=1 SV=1,0,95.905,43,14,173,13,364,40.7,8.88,69357,,14,,regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;mitochondrion,nucleotide binding;protein binding,"Pf01926, Pf02421, Pf02824, Pf08477",1819,ENSG00000108591.9,DRG2,17,,,,0,High,1
Q9NUQ7,Ufm1-specific protease 2 OS=Homo sapiens OX=9606 GN=UFSP2 PE=1 SV=3,0,95.872,46,15,123,15,469,53.2,7.01,52463,,15,,metabolic process;regulation of biological process,cytoplasm;endoplasmic reticulum;nucleus,catalytic activity;protein binding,Pf07910,55325,ENSG00000109775.10,UFSP2,4,,,,0,High,1
Q9NYL9,Tropomodulin-3 OS=Homo sapiens OX=9606 GN=TMOD3 PE=1 SV=1,0,95.828,48,15,156,14,352,39.6,5.19,78174,,15,,cell organization and biogenesis;regulation of biological process,cytoplasm;cytoskeleton,protein binding,Pf03250,29766,ENSG00000138594.13,TMOD3,15,,,Striated Muscle Contraction,2,High,1
P54619,5'-AMP-activated protein kinase subunit gamma-1 OS=Homo sapiens OX=9606 GN=PRKAG1 PE=1 SV=1,0,95.799,54,14,143,13,331,37.6,6.92,67070,6.8,14,3,cell communication;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;membrane;nucleus,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding,"Pf00478, Pf00571",5571,ENSG00000181929.11,PRKAG1,12,Oxytocin signaling pathway; Longevity regulating pathway - multiple species; Longevity regulating pathway; Circadian rhythm; Glucagon signaling pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Non-alcoholic fatty liver disease (NAFLD); Hypertrophic cardiomyopathy (HCM); Insulin resistance; AMPK signaling pathway; FoxO signaling pathway,AMP-activated Protein Kinase (AMPK) Signaling; Target Of Rapamycin (TOR) Signaling; Energy Metabolism; Sterol Regulatory Element-Binding Proteins (SREBP) signalling; Angiopoietin Like Protein 8 Regulatory Pathway; Leptin and adiponectin,Translocation of GLUT4 to the plasma membrane; Energy dependent regulation of mTOR by LKB1-AMPK; TP53 Regulates Metabolic Genes; Regulation of TP53 Activity through Phosphorylation; Macroautophagy; Activation of PPARGC1A (PGC-1alpha) by phosphorylation,36,High,1
P49321,Nuclear autoantigenic sperm protein OS=Homo sapiens OX=9606 GN=NASP PE=1 SV=2,0,95.769,35,16,53,16,788,85.2,4.3,25820,,16,,cell organization and biogenesis;cell proliferation;metabolic process;response to stimulus;transport,cytoplasm;nucleus,protein binding,"Pf00515, Pf10516, Pf13414, Pf13424",4678,ENSG00000132780.16,NASP,1,,,,0,High,1
P20339,Ras-related protein Rab-5A OS=Homo sapiens OX=9606 GN=RAB5A PE=1 SV=2,0,95.669,53,11,195,6,215,23.6,8.15,87211,0,11,1,cell organization and biogenesis;coagulation;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endosome;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00009, Pf00025, Pf00071, Pf04670, Pf08477",5868,ENSG00000144566.10,RAB5A,3,Ras signaling pathway; Phagosome; Endocytosis; Amyotrophic lateral sclerosis (ALS); Tuberculosis; Vasopressin-regulated water reabsorption; Amoebiasis,Amyotrophic lateral sclerosis (ALS); VEGFA-VEGFR2 Signaling Pathway; EGF/EGFR Signaling Pathway,TBC/RABGAPs; Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; RAB GEFs exchange GTP for GDP on RABs; Factors involved in megakaryocyte development and platelet production; RAB geranylgeranylation,26,High,1
Q5XKP0,MICOS complex subunit MIC13 OS=Homo sapiens OX=9606 GN=MICOS13 PE=1 SV=1,0,95.595,62,9,469,9,118,13.1,9.42,184421,66.86,8,2,cell organization and biogenesis,membrane;mitochondrion,,,125988,ENSG00000174917.8,C19orf70,19,,,Cristae formation,3,High,1
Q00169,Phosphatidylinositol transfer protein alpha isoform OS=Homo sapiens OX=9606 GN=PITPNA PE=1 SV=2,0,95.57,49,14,183,12,270,31.8,6.55,75197,,14,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol,transporter activity,Pf02121,5306,ENSG00000174238.14,PITPNA,17,,,Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Interleukin-12 family signaling; Role of second messengers in netrin-1 signaling,9,High,1
Q9NR45,Sialic acid synthase OS=Homo sapiens OX=9606 GN=NANS PE=1 SV=2,0,95.484,33,8,172,8,359,40.3,6.74,73931,,8,,metabolic process,cytoplasm;cytosol,catalytic activity,"Pf03102, Pf08666",54187,ENSG00000095380.10,NANS,9,Metabolic pathways; Amino sugar and nucleotide sugar metabolism,,Sialic acid metabolism,8,High,1
P46781,40S ribosomal protein S9 OS=Homo sapiens OX=9606 GN=RPS9 PE=1 SV=3,0,95.431,41,15,377,15,194,22.6,10.65,180873,0,15,2,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;membrane;nucleus;ribosome,protein binding;RNA binding;structural molecule activity;translation regulator activity,"Pf00163, Pf01479",6203,ENSG00000274005.3; ENSG00000275323.3; ENSG00000277079.3; ENSG00000278081.3; ENSG00000277359.3; ENSG00000170889.13; ENSG00000274950.4; ENSG00000274626.3; ENSG00000278270.4; ENSG00000274646.4,RPS9,19; CHR_HSCHR19LRC_LRC_T_CTG3_1; CHR_HSCHR19LRC_LRC_J_CTG3_1; CHR_HSCHR19LRC_PGF2_CTG3_1; CHR_HSCHR19LRC_LRC_S_CTG3_1; CHR_HSCHR19LRC_LRC_I_CTG3_1; CHR_HSCHR19LRC_PGF1_CTG3_1; CHR_HSCHR19LRC_COX2_CTG3_1; CHR_HSCHR19_4_CTG3_1; CHR_HSCHR19LRC_COX1_CTG3_1,Ribosome,Cytoplasmic Ribosomal Proteins,"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane",39,High,1
Q14155-1,Isoform 1 of Rho guanine nucleotide exchange factor 7 OS=Homo sapiens OX=9606 GN=ARHGEF7,0,95.385,33,17,112,13,646,73.1,7.21,39646,0,17,1,cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus,cytosol;membrane;vacuole,protein binding,"Pf00018, Pf00169, Pf00621, Pf07653, Pf14604",8874,ENSG00000102606.17,ARHGEF7,13,,Integrin-mediated Cell Adhesion; Regulation of Actin Cytoskeleton,,2,High,1
P00167,Cytochrome b5 OS=Homo sapiens OX=9606 GN=CYB5A PE=1 SV=2,0,95.346,56,7,283,7,134,15.3,4.96,136401,0,7,1,metabolic process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;membrane;mitochondrion,catalytic activity;metal ion binding;protein binding;transporter activity,Pf00173,1528,ENSG00000166347.18,CYB5A,18,,Oxidation by Cytochrome P450,Vitamin C (ascorbate) metabolism,5,High,1
Q9UJW0,Dynactin subunit 4 OS=Homo sapiens OX=9606 GN=DCTN4 PE=1 SV=1,0,95.339,35,11,106,11,460,52.3,7.34,50804,,11,,transport,chromosome;cytoplasm;cytoskeleton;cytosol;nucleus,protein binding,Pf05502,51164,ENSG00000132912.12,DCTN4,5,Vasopressin-regulated water reabsorption; Huntington's disease,,COPI-independent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR),19,High,1
Q9BRG1,Vacuolar protein-sorting-associated protein 25 OS=Homo sapiens OX=9606 GN=VPS25 PE=1 SV=1,0,95.277,48,10,185,10,176,20.7,6.34,93264,2.48,10,1,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane;nucleus,protein binding;structural molecule activity,Pf05871,84313,ENSG00000131475.6,VPS25,17,Endocytosis,,Endosomal Sorting Complex Required For Transport (ESCRT),4,High,1
Q15121,Astrocytic phosphoprotein PEA-15 OS=Homo sapiens OX=9606 GN=PEA15 PE=1 SV=2,0,95.218,52,7,202,7,130,15,5.02,106530,,7,,cell death;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus,protein binding,Pf01335,8682,ENSG00000162734.12,PEA15,1,,Apoptosis Modulation and Signaling,RAF-independent MAPK1/3 activation; RAF/MAP kinase cascade; Interleukin-20 family signaling,10,High,1
Q8NC56,LEM domain-containing protein 2 OS=Homo sapiens OX=9606 GN=LEMD2 PE=1 SV=1,0,95.18,43,16,92,16,503,56.9,9,42632,4.2,15,1,cell differentiation;cell organization and biogenesis;regulation of biological process,chromosome;endoplasmic reticulum;membrane;nucleus,DNA binding;protein binding,"Pf03020, Pf09402",221496,ENSG00000161904.11,LEMD2,6,,,Depolymerisation of the Nuclear Lamina; Initiation of Nuclear Envelope Reformation; Clearance of Nuclear Envelope Membranes from Chromatin,11,High,1
P49585,Choline-phosphate cytidylyltransferase A OS=Homo sapiens OX=9606 GN=PCYT1A PE=1 SV=2,0,95.149,47,13,101,13,367,41.7,7.25,48697,,13,,metabolic process,cytoplasm;cytosol;endoplasmic reticulum;membrane,catalytic activity;protein binding,Pf01467,5130,ENSG00000161217.11,PCYT1A,3,Choline metabolism in cancer; Metabolic pathways; Glycerophospholipid metabolism,Kennedy pathway; One carbon metabolism and related pathways; Acetylcholine Synthesis,Synthesis of PC,11,High,1
P26373,60S ribosomal protein L13 OS=Homo sapiens OX=9606 GN=RPL13 PE=1 SV=4,0,95.146,37,12,559,12,211,24.2,11.65,239113,0,12,3,cell organization and biogenesis;metabolic process;transport,cytosol;membrane;nucleus;ribosome,protein binding;RNA binding;structural molecule activity,Pf01294,6137,ENSG00000167526.13,RPL13,16,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
P20290,Transcription factor BTF3 OS=Homo sapiens OX=9606 GN=BTF3 PE=1 SV=1,0,95.142,46,6,91,6,206,22.2,9.38,43836,,6,,metabolic process;regulation of biological process;transport,cytoplasm;cytosol;nucleus,protein binding;RNA binding,Pf01849,689,ENSG00000145741.15,BTF3,5,,,,0,High,1
Q8IXI1,Mitochondrial Rho GTPase 2 OS=Homo sapiens OX=9606 GN=RHOT2 PE=1 SV=2,0,95.12,25,11,175,9,618,68.1,5.86,77707,,11,,cell organization and biogenesis;cellular component movement;cellular homeostasis;regulation of biological process;response to stimulus;transport,cytosol;membrane;mitochondrion,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00071, Pf01926, Pf08355, Pf08356, Pf08477, Pf13479",89941,ENSG00000140983.13,RHOT2,16,,,Rho GTPase cycle,3,High,1
O15357,"Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 OS=Homo sapiens OX=9606 GN=INPPL1 PE=1 SV=2",0,95.043,27,24,90,24,1258,138.5,6.54,29091,0,24,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;Golgi;membrane,catalytic activity;protein binding,"Pf00017, Pf00536, Pf03372, Pf07647",3636,ENSG00000165458.13,INPPL1,11,Phosphatidylinositol signaling system; Fc gamma R-mediated phagocytosis; Insulin signaling pathway; Inositol phosphate metabolism; B cell receptor signaling pathway,EGF/EGFR Signaling Pathway; Insulin Signaling,Synthesis of IP3 and IP4 in the cytosol; Synthesis of PIPs at the plasma membrane; Interleukin receptor SHC signaling,20,High,1
Q9H1Z4,WD repeat-containing protein 13 OS=Homo sapiens OX=9606 GN=WDR13 PE=1 SV=2,0,95.039,32,12,85,12,485,53.7,9.14,39412,1.69,12,1,,membrane;nucleus,protein binding,Pf00400,64743,,WDR13,X,,,,0,High,1
Q9Y3D9,"28S ribosomal protein S23, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS23 PE=1 SV=2",0,94.994,62,10,179,10,190,21.8,8.9,80312,0,10,1,cell organization and biogenesis;metabolic process,cytoskeleton;membrane;mitochondrion;ribosome,protein binding;RNA binding;structural molecule activity,"Pf10484, Pf13741",51649,ENSG00000181610.12,MRPS23,17,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
Q9NZA1-2,Isoform 1 of Chloride intracellular channel protein 5 OS=Homo sapiens OX=9606 GN=CLIC5,0,94.915,43,10,155,9,251,28.2,6,57787,11.63,9,2,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;Golgi;membrane;nucleus,catalytic activity;protein binding;transporter activity,"Pf13409, Pf13410, Pf13417",53405,ENSG00000112782.15,CLIC5,6,,,,0,High,1
Q9UN37,Vacuolar protein sorting-associated protein 4A OS=Homo sapiens OX=9606 GN=VPS4A PE=1 SV=1,0,94.783,26,12,164,7,437,48.9,7.8,67766,0,12,1,cell communication;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane;nucleus;vacuole,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00004, Pf00910, Pf01078, Pf01695, Pf04212, Pf04389, Pf06068, Pf07724, Pf07728, Pf09336, Pf13173, Pf13207, Pf13401",27183,ENSG00000132612.15,VPS4A,16,Endocytosis,,Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT),10,High,1
P12268,Inosine-5'-monophosphate dehydrogenase 2 OS=Homo sapiens OX=9606 GN=IMPDH2 PE=1 SV=2,0,94.78,34,15,150,13,514,55.8,6.9,69218,0,15,1,cell organization and biogenesis;cell proliferation;metabolic process;response to stimulus;transport,cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen,catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding,"Pf00478, Pf00571, Pf00977, Pf01070, Pf03060",3615,ENSG00000178035.11,IMPDH2,3,Purine metabolism; Drug metabolism - other enzymes; Metabolic pathways,,Neutrophil degranulation; Purine ribonucleoside monophosphate biosynthesis,10,High,1
Q9Y2H5,Pleckstrin homology domain-containing family A member 6 OS=Homo sapiens OX=9606 GN=PLEKHA6 PE=1 SV=4,0,94.69,25,20,99,20,1048,117.1,9.1,31521,2.63,19,1,,,,"Pf00169, Pf15413",22874,ENSG00000143850.13,PLEKHA6,1,,,Synthesis of PIPs at the plasma membrane,5,High,1
P13671,Complement component C6 OS=Homo sapiens OX=9606 GN=C6 PE=1 SV=3,0,94.559,16,10,85,10,934,104.7,6.76,39708,,10,,defense response;metabolic process;regulation of biological process;response to stimulus,extracellular,protein binding,"Pf00057, Pf00084, Pf00090, Pf01823",729,ENSG00000039537.13,C6,5,Systemic lupus erythematosus; Prion diseases; Complement and coagulation cascades,Allograft Rejection; Complement Activation; Complement and Coagulation Cascades,Terminal pathway of complement; Regulation of Complement cascade,11,High,1
Q9NR12,PDZ and LIM domain protein 7 OS=Homo sapiens OX=9606 GN=PDLIM7 PE=1 SV=1,0,94.553,41,12,107,1,457,49.8,8.41,46954,3.52,12,2,cell differentiation;cell organization and biogenesis;cellular component movement;development;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;nucleus,metal ion binding;protein binding,"Pf00412, Pf00595",9260,ENSG00000196923.13,PDLIM7,5,,EBV LMP1 signaling,RET signaling,4,High,1
Q8NFF5,FAD synthase OS=Homo sapiens OX=9606 GN=FLAD1 PE=1 SV=1,0,94.505,30,13,100,13,587,65.2,6.93,46673,,13,,metabolic process,cytoplasm;cytosol;membrane;mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding,"Pf00994, Pf01507",80308,ENSG00000160688.18,FLAD1,1,Riboflavin metabolism; Metabolic pathways,Selenium Micronutrient Network; Folate Metabolism,Vitamin B2 (riboflavin) metabolism,8,High,1
Q92890-1,Isoform Long of Ubiquitin recognition factor in ER-associated degradation protein 1 OS=Homo sapiens OX=9606 GN=UFD1,0,94.385,39,12,199,12,343,38.7,6.34,91881,0,12,2,metabolic process;regulation of biological process;response to stimulus;transport,cytosol;endoplasmic reticulum;nucleus,catalytic activity;protein binding,Pf03152,7353,,UFD1L; UFD1,22,,,,0,High,1
P12955,Xaa-Pro dipeptidase OS=Homo sapiens OX=9606 GN=PEPD PE=1 SV=3,0,94.326,29,13,187,13,493,54.5,6,87790,0,13,1,metabolic process,,catalytic activity;metal ion binding;protein binding,"Pf00557, Pf05195",5184,ENSG00000124299.13,PEPD,19,,,,0,High,1
Q9NPQ8,Synembryn-A OS=Homo sapiens OX=9606 GN=RIC8A PE=1 SV=3,0,94.267,39,19,135,18,531,59.7,5.33,54878,0,19,1,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cytoplasm;membrane,enzyme regulator activity;protein binding,Pf10165,60626,ENSG00000177963.14,RIC8A,11,,,,0,High,1
Q96PU8,Protein quaking OS=Homo sapiens OX=9606 GN=QKI PE=1 SV=1,0,94.226,48,12,111,12,341,37.6,8.56,49286,5.89,12,1,cell differentiation;development;metabolic process;regulation of biological process;transport,cytoplasm;nucleus,protein binding;RNA binding,"Pf00013, Pf13014",9444,ENSG00000112531.16,QKI,6,,Exercise-induced Circadian Regulation,Signaling by BRAF and RAF fusions,5,High,1
Q04323,UBX domain-containing protein 1 OS=Homo sapiens OX=9606 GN=UBXN1 PE=1 SV=2,0,94.116,51,9,59,9,297,33.3,5.25,28749,1.67,9,1,metabolic process;regulation of biological process,cytoplasm;cytosol;endoplasmic reticulum;nucleus;proteasome,protein binding,"Pf00627, Pf00789",51035,ENSG00000162191.13,UBXN1,11,,,N-glycan trimming in the ER and Calnexin/Calreticulin cycle,4,High,1
Q96GD0,Pyridoxal phosphate phosphatase OS=Homo sapiens OX=9606 GN=PDXP PE=1 SV=2,0,94.099,38,10,99,8,296,31.7,6.55,49212,0,10,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane,catalytic activity;metal ion binding;protein binding,"Pf00702, Pf09419, Pf13242, Pf13344, Pf13419",57026,ENSG00000241360.1,PDXP,22,Metabolic pathways; Vitamin B6 metabolism,,,2,High,1
P09429,High mobility group protein B1 OS=Homo sapiens OX=9606 GN=HMGB1 PE=1 SV=3,0,94.072,22,6,271,6,215,24.9,5.74,148051,,6,,cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;chromosome;cytoplasm;endosome;extracellular;membrane;nucleus;organelle lumen,catalytic activity;DNA binding;enzyme regulator activity;protein binding;RNA binding,"Pf00505, Pf09011",3146,ENSG00000189403.14,HMGB1,13,Base excision repair,Retinoblastoma (RB) in Cancer; DNA Damage Response (only ATM dependent),TRAF6 mediated NF-kB activation; Advanced glycosylation endproduct receptor signaling; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; RIP-mediated NFkB activation via ZBP1; Activated TLR4 signalling; Interleukin-1 family signaling; Neutrophil degranulation; Regulation of TLR by endogenous ligand; DEx/H-box helicases activate type I IFN and inflammatory cytokines production ; Activation of DNA fragmentation factor,40,High,1
O60662,Kelch-like protein 41 OS=Homo sapiens OX=9606 GN=KLHL41 PE=1 SV=2,0,94.047,26,14,311,14,606,68,5.29,124809,170.38,8,7,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;nucleus,catalytic activity;protein binding,"Pf00651, Pf01344, Pf07646, Pf07707, Pf13415, Pf13418, Pf13964",10324,ENSG00000239474.6,KBTBD10; KLHL41,2,,,Antigen processing: Ubiquitination & Proteasome degradation; Neddylation,7,High,1
O00487,26S proteasome non-ATPase regulatory subunit 14 OS=Homo sapiens OX=9606 GN=PSMD14 PE=1 SV=1,0,93.796,41,10,179,10,310,34.6,6.52,75901,0,10,2,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;nucleus;organelle lumen;proteasome,catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding,"Pf01398, Pf13012, Pf14464",10213,ENSG00000115233.11,PSMD14,2,Epstein-Barr virus infection; Proteasome,Parkin-Ubiquitin Proteasomal System pathway,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Neutrophil degranulation; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Metalloprotease DUBs; Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,153,High,1
Q9UBX3,Mitochondrial dicarboxylate carrier OS=Homo sapiens OX=9606 GN=SLC25A10 PE=1 SV=2,0,93.703,43,13,190,13,287,31.3,9.54,82198,0,13,2,metabolic process;transport,membrane;mitochondrion;nucleus,protein binding;transporter activity,Pf00153,1468,ENSG00000183048.11,SLC25A10,17,Proximal tubule bicarbonate reclamation,,Gluconeogenesis; Sulfide oxidation to sulfate; Organic anion transporters,13,High,1
O94832,Unconventional myosin-Id OS=Homo sapiens OX=9606 GN=MYO1D PE=1 SV=2,0,93.676,19,17,80,16,1006,116.1,9.39,36153,,17,,regulation of biological process;transport,cytosol;endoplasmic reticulum;endosome;membrane,catalytic activity;motor activity;nucleotide binding;protein binding,"Pf00063, Pf06017",4642,ENSG00000176658.16,MYO1D,17,,,,0,High,1
Q9H9G7,Protein argonaute-3 OS=Homo sapiens OX=9606 GN=AGO3 PE=1 SV=2,0,93.57,24,15,78,8,860,97.3,9.11,32902,7.51,14,2,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;cytosol;membrane,protein binding;RNA binding,"Pf02170, Pf02171, Pf08699",192669,ENSG00000126070.19,AGO3; EIF2C3,1,,,Post-transcriptional silencing by small RNAs; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Ca2+ pathway; MicroRNA (miRNA) biogenesis; Competing endogenous RNAs (ceRNAs) regulate PTEN translation; Small interfering RNA (siRNA) biogenesis; Regulation of RUNX1 Expression and Activity; MAPK6/MAPK4 signaling; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Pre-NOTCH Transcription and Translation; Oxidative Stress Induced Senescence,31,High,1
Q9NR28,"Diablo homolog, mitochondrial OS=Homo sapiens OX=9606 GN=DIABLO PE=1 SV=1",0,93.566,63,10,197,10,239,27.1,5.9,100205,,10,,cell death;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;mitochondrion,protein binding,Pf09057,56616,ENSG00000184047.16,DIABLO,12,Apoptosis - multiple species; Apoptosis,TNF alpha Signaling Pathway; Nanomaterial induced apoptosis; Apoptosis,SMAC-mediated dissociation of IAP:caspase complexes ; SMAC binds to IAPs ; Release of apoptotic factors from the mitochondria,13,High,1
Q9BS26,Endoplasmic reticulum resident protein 44 OS=Homo sapiens OX=9606 GN=ERP44 PE=1 SV=1,0,93.527,29,12,151,12,406,46.9,5.26,76897,2,11,1,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;endoplasmic reticulum;extracellular;membrane;organelle lumen,catalytic activity;metal ion binding;protein binding,"Pf00085, Pf01216, Pf07449, Pf13098, Pf13848",23071,ENSG00000023318.7,ERP44,9,,,Neutrophil degranulation,3,High,1
P35914,"Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Homo sapiens OX=9606 GN=HMGCL PE=1 SV=2",0,93.494,40,11,260,11,325,34.3,8.54,127543,1.78,10,1,cell organization and biogenesis;metabolic process;response to stimulus,membrane;mitochondrion;organelle lumen,catalytic activity;metal ion binding;protein binding,Pf00682,3155,ENSG00000117305.14,HMGCL,1,"Synthesis and degradation of ketone bodies; Valine, leucine and isoleucine degradation; Butanoate metabolism; Metabolic pathways; Peroxisome",Synthesis and Degradation of Ketone Bodies; Amino Acid metabolism,Synthesis of Ketone Bodies,11,High,1
Q8N3D4,EH domain-binding protein 1-like protein 1 OS=Homo sapiens OX=9606 GN=EHBP1L1 PE=1 SV=2,0,93.484,18,18,49,18,1523,161.8,4.83,22064,,18,,,endosome;membrane,protein binding,"Pf00307, Pf10358, Pf11971, Pf12130",254102,ENSG00000173442.12,EHBP1L1,11,,,,0,High,1
Q9NR12-2,Isoform 2 of PDZ and LIM domain protein 7 OS=Homo sapiens OX=9606 GN=PDLIM7,0,93.481,43,12,105,1,423,46.5,8.34,45874,6.66,11,3,cell organization and biogenesis;cellular component movement;regulation of biological process;transport,cytoskeleton;cytosol;nucleus,metal ion binding;protein binding,"Pf00412, Pf00595",9260,ENSG00000196923.13,PDLIM7,5,,EBV LMP1 signaling,,1,High,1
P05067,Amyloid-beta precursor protein OS=Homo sapiens OX=9606 GN=APP PE=1 SV=3,0,93.443,21,14,104,13,770,86.9,4.82,36608,,14,,cell communication;cell death;cell growth;cell organization and biogenesis;cellular component movement;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;cytosol;endoplasmic reticulum;endosome;extracellular;Golgi;membrane;organelle lumen;vacuole,DNA binding;enzyme regulator activity;metal ion binding;protein binding,"Pf00014, Pf02177, Pf03494, Pf03938, Pf10515, Pf11740, Pf12924, Pf12925, Pf13868, Pf15463",351,ENSG00000142192.20,APP,21,Alzheimer's disease; Serotonergic synapse,Alzheimers Disease; Endoderm Differentiation; Apoptosis-related network due to altered Notch3 in ovarian cancer; Copper homeostasis; TGF-beta Signaling Pathway,Post-translational protein phosphorylation; TRAF6 mediated NF-kB activation; G alpha (i) signalling events; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; RIP-mediated NFkB activation via ZBP1; Activated TLR4 signalling; Interleukin-1 family signaling; The NLRP3 inflammasome; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Amyloid fiber formation; Advanced glycosylation endproduct receptor signaling; Formyl peptide receptors bind formyl peptides and many other ligands; Lysosome Vesicle Biogenesis; Platelet degranulation ; ECM proteoglycans; Gastrin-CREB signalling pathway via PKC and MAPK; DEx/H-box helicases activate type I IFN and inflammatory cytokines production,69,High,1
P07910-2,Isoform C1 of Heterogeneous nuclear ribonucleoproteins C1/C2 OS=Homo sapiens OX=9606 GN=HNRNPC,0,93.424,35,11,386,11,293,32.3,5.08,190097,18.11,10,1,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process,cytoskeleton;cytosol;extracellular;membrane;nucleus;spliceosomal complex,DNA binding;protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",3183,ENSG00000092199.17,HNRNPC,14,,mRNA Processing,,1,High,1
P50552,Vasodilator-stimulated phosphoprotein OS=Homo sapiens OX=9606 GN=VASP PE=1 SV=3,0,93.392,26,11,110,11,380,39.8,8.94,58335,0,11,1,cell organization and biogenesis;cellular component movement;regulation of biological process,cytoplasm;cytoskeleton;cytosol;membrane,protein binding,Pf00568,7408,ENSG00000125753.13,VASP,19,Focal adhesion; Fc gamma R-mediated phagocytosis; Rap1 signaling pathway; Leukocyte transendothelial migration; cGMP-PKG signaling pathway; Platelet activation,Integrin-mediated Cell Adhesion; Focal Adhesion,Cell-extracellular matrix interactions; Generation of second messenger molecules; Signaling by ROBO receptors,18,High,1
Q9BXS5,AP-1 complex subunit mu-1 OS=Homo sapiens OX=9606 GN=AP1M1 PE=1 SV=3,0,93.334,51,16,194,16,423,48.6,7.3,73335,,16,,cell organization and biogenesis;regulation of biological process;transport,cytosol;Golgi;membrane,protein binding,Pf00928,8907,ENSG00000072958.8,AP1M1,19,Lysosome,,Neutrophil degranulation; Nef mediated downregulation of MHC class I complex cell surface expression; MHC class II antigen presentation; Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis,19,High,1
P01871,Immunoglobulin heavy constant mu OS=Homo sapiens OX=9606 GN=IGHM PE=1 SV=4,0,93.288,30,12,418,12,453,49.4,6.77,176367,17.18,11,2,cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus,cell surface;extracellular;membrane,DNA binding;protein binding,"Pf00047, Pf07654, Pf08205",3507,ENSG00000282657.3; ENSG00000211899.9,IGHM,CHR_HSCHR14_3_CTG1; 14,,,CD22 mediated BCR regulation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Cell surface interactions at the vascular wall,7,High,1
Q9NSK0,Kinesin light chain 4 OS=Homo sapiens OX=9606 GN=KLC4 PE=1 SV=3,0,93.219,31,16,84,13,619,68.6,6.18,36319,0,16,1,,cytoplasm;cytoskeleton,catalytic activity;motor activity;protein binding,"Pf00515, Pf09311, Pf13374, Pf13414, Pf13424, Pf13432, Pf14559",89953,ENSG00000137171.14,KLC4,6,Salmonella infection,,COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; RHO GTPases activate KTN1; MHC class II antigen presentation,16,High,1
P21283,V-type proton ATPase subunit C 1 OS=Homo sapiens OX=9606 GN=ATP6V1C1 PE=1 SV=4,0,93.215,46,13,82,13,382,43.9,7.46,43695,,13,,cellular homeostasis;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane,catalytic activity;protein binding;transporter activity,Pf03223,528,ENSG00000155097.11,ATP6V1C1,8,Collecting duct acid secretion; Vibrio cholerae infection; Phagosome; Rheumatoid arthritis; Epithelial cell signaling in Helicobacter pylori infection; Oxidative phosphorylation; Synaptic vesicle cycle; Metabolic pathways; mTOR signaling pathway,,"Transferrin endocytosis and recycling; ROS, RNS production in phagocytes; Ion channel transport; Insulin receptor recycling",20,High,1
Q9HAT2,Sialate O-acetylesterase OS=Homo sapiens OX=9606 GN=SIAE PE=1 SV=1,0,93.192,25,12,188,12,523,58.3,7.33,93173,0,12,1,metabolic process;regulation of biological process,extracellular;vacuole,catalytic activity,Pf03629,54414,ENSG00000110013.12,SIAE,11,,,,0,High,1
Q9HB90,Ras-related GTP-binding protein C OS=Homo sapiens OX=9606 GN=RRAGC PE=1 SV=1,0,93.171,37,10,93,5,399,44.2,5.1,42816,0,10,1,cell communication;cell death;cell growth;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus;vacuole,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00025, Pf04670",64121,ENSG00000116954.7,RRAGC,1,mTOR signaling pathway,Target Of Rapamycin (TOR) Signaling,Energy dependent regulation of mTOR by LKB1-AMPK; Regulation of PTEN gene transcription; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Macroautophagy,17,High,1
Q9UHB9,Signal recognition particle subunit SRP68 OS=Homo sapiens OX=9606 GN=SRP68 PE=1 SV=2,0,93.157,29,16,74,16,627,70.7,8.56,32334,,16,,cell organization and biogenesis;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;nucleus;ribosome,protein binding;RNA binding,,6730,ENSG00000167881.14,SRP68,17,Protein export,,SRP-dependent cotranslational protein targeting to membrane,4,High,1
Q02221,"Cytochrome c oxidase subunit 6A2, mitochondrial OS=Homo sapiens OX=9606 GN=COX6A2 PE=2 SV=2",0,93.075,42,6,443,6,97,10.8,10.9,207597,63.54,6,1,metabolic process;regulation of biological process;transport,membrane;mitochondrion,catalytic activity;enzyme regulator activity;transporter activity,Pf02046,1339,ENSG00000156885.5,COX6A2,16,Huntington's disease; Oxidative phosphorylation; Metabolic pathways; Parkinson's disease; Cardiac muscle contraction; Non-alcoholic fatty liver disease (NAFLD); Alzheimer's disease,Electron Transport Chain,,8,High,1
Q9BYV7,"Beta,beta-carotene 9',10'-oxygenase OS=Homo sapiens OX=9606 GN=BCO2 PE=1 SV=5",0,93.055,30,14,132,14,579,65.6,8.41,51473,39.11,13,2,metabolic process;regulation of biological process,mitochondrion;organelle lumen,catalytic activity;metal ion binding,Pf03055,83875,ENSG00000197580.11,BCO2,11,,Vitamin A and Carotenoid Metabolism,Signaling by GPCR; Retinoid metabolism and transport,8,High,1
P48729,Casein kinase I isoform alpha OS=Homo sapiens OX=9606 GN=CSNK1A1 PE=1 SV=2,0,93.04,36,11,171,11,337,38.9,9.57,81257,,11,,cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,chromosome;cytoplasm;cytoskeleton;cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf07714",1452,ENSG00000113712.17,CSNK1A1,5,Wnt signaling pathway; Hedgehog signaling pathway; Breast cancer,T-Cell Receptor and Co-stimulatory Signaling; Wnt Signaling Pathway Netpath; Wnt/beta-catenin Signaling Pathway in Leukemia; Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds,S37 mutants of beta-catenin aren't phosphorylated; Beta-catenin phosphorylation cascade; AXIN missense mutants destabilize the destruction complex; S33 mutants of beta-catenin aren't phosphorylated; Disassembly of the destruction complex and recruitment of AXIN to the membrane; APC truncation mutants have impaired AXIN binding; S45 mutants of beta-catenin aren't phosphorylated; GLI3 is processed to GLI3R by the proteasome; Misspliced GSK3beta mutants stabilize beta-catenin; Activation of SMO; Degradation of GLI2 by the proteasome; T41 mutants of beta-catenin aren't phosphorylated; Truncations of AMER1 destabilize the destruction complex,34,High,1
P56134-2,"Isoform 2 of ATP synthase subunit f, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5MF",0,93.036,51,9,1116,2,88,10.4,9.86,510940,212.29,7,4,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion;nucleus,catalytic activity;transporter activity,Pf10206,9551,ENSG00000241468.7,ATP5J2,7,,Electron Transport Chain; Oxidative phosphorylation,,2,High,1
Q13884,Beta-1-syntrophin OS=Homo sapiens OX=9606 GN=SNTB1 PE=1 SV=3,0,93.014,39,16,137,15,538,58,8.63,63440,0,16,1,,cytoplasm;cytoskeleton;membrane,protein binding;structural molecule activity,"Pf00169, Pf00595",6641,ENSG00000172164.13,SNTB1,8,,,,0,High,1
Q96GW9,"Methionine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=MARS2 PE=1 SV=2",0,92.944,35,14,86,14,593,66.5,8.09,35028,2.93,13,2,metabolic process,cytoplasm;mitochondrion;organelle lumen,catalytic activity;nucleotide binding,"Pf00133, Pf01406, Pf08264, Pf09334",92935,ENSG00000247626.4,MARS2,2,Selenocompound metabolism; Aminoacyl-tRNA biosynthesis,Amino Acid metabolism,Mitochondrial tRNA aminoacylation,7,High,1
Q15637,Splicing factor 1 OS=Homo sapiens OX=9606 GN=SF1 PE=1 SV=4,0,92.868,24,10,103,10,639,68.3,8.98,46006,,10,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process,nucleus;ribosome;spliceosomal complex,metal ion binding;protein binding;RNA binding,"Pf00013, Pf00098, Pf13014",7536,ENSG00000168066.20,SF1,11,,,mRNA Splicing - Major Pathway,4,High,1
Q9UJU6,Drebrin-like protein OS=Homo sapiens OX=9606 GN=DBNL PE=1 SV=1,0,92.829,25,8,84,8,430,48.2,5.05,42902,,8,,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endosome;extracellular;Golgi;membrane;organelle lumen,enzyme regulator activity;protein binding,"Pf00018, Pf00241, Pf07653, Pf14604",28988,ENSG00000136279.20,DBNL,7,,T-Cell antigen Receptor (TCR)  Signaling Pathway,Neutrophil degranulation; Caspase-mediated cleavage of cytoskeletal proteins; Neurexins and neuroligins,12,High,1
P31153,S-adenosylmethionine synthase isoform type-2 OS=Homo sapiens OX=9606 GN=MAT2A PE=1 SV=1,0,92.81,29,10,173,10,395,43.6,6.48,85215,,10,,cell organization and biogenesis;metabolic process,cytosol,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00438, Pf02772, Pf02773",4144,ENSG00000168906.12,MAT2A,2,Cysteine and methionine metabolism; Biosynthesis of amino acids; Metabolic pathways,Trans-sulfuration and one carbon metabolism; One carbon metabolism and related pathways; Methylation Pathways,Methylation,10,High,1
P10636,Microtubule-associated protein tau OS=Homo sapiens OX=9606 GN=MAPT PE=1 SV=5,0,92.778,30,14,71,14,758,78.9,6.71,29497,0,14,2,cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,DNA binding;protein binding,Pf00418,4137,ENSG00000186868.15,MAPT,17,MAPK signaling pathway; Alzheimer's disease,IL-5 Signaling Pathway; Regulation of Microtubule Cytoskeleton; Alzheimers Disease; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Kit receptor signaling pathway; Copper homeostasis; MAPK Signaling Pathway; IL-2 Signaling Pathway; Notch Signaling Pathway,Caspase-mediated cleavage of cytoskeletal proteins,16,High,1
P01877,Immunoglobulin heavy constant alpha 2 OS=Homo sapiens OX=9606 GN=IGHA2 PE=1 SV=4,0,92.772,29,9,371,2,340,36.6,6.27,190019,69.04,8,1,cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,protein binding,"Pf07654, Pf08205",3494,ENSG00000211890.3,IGHA2,14,,Inflammatory Response Pathway,Scavenging of heme from plasma; Cell surface interactions at the vascular wall,6,High,1
P55010,Eukaryotic translation initiation factor 5 OS=Homo sapiens OX=9606 GN=EIF5 PE=1 SV=2,0,92.705,20,8,240,8,431,49.2,5.58,126715,0,8,1,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf01873, Pf02020",1983,ENSG00000100664.10,EIF5,14,RNA transport,Translation Factors,GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition,8,High,1
Q08495-2,Isoform 2 of Dematin OS=Homo sapiens OX=9606 GN=DMTN,0,92.557,45,13,85,13,383,43.1,8.85,34536,7,12,1,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoskeleton;cytosol;membrane,protein binding,Pf02209,2039,ENSG00000158856.17,DMTN; EPB49,8,,,,0,High,1
Q15276,Rab GTPase-binding effector protein 1 OS=Homo sapiens OX=9606 GN=RABEP1 PE=1 SV=2,0,92.498,27,17,67,17,862,99.2,5.01,28649,,17,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;endosome;membrane,enzyme regulator activity;protein binding;transporter activity,"Pf01496, Pf03528, Pf04111, Pf09311, Pf09726, Pf12128, Pf13949",9135,ENSG00000029725.16,RABEP1,17,Endocytosis,,TBC/RABGAPs,5,High,1
P00492,Hypoxanthine-guanine phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=HPRT1 PE=1 SV=2,0,92.467,44,13,227,13,218,24.6,6.68,105883,,13,,cell differentiation;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00156, Pf15610",3251,ENSG00000165704.14,HPRT1,X,Metabolic pathways; Purine metabolism; Drug metabolism - other enzymes,Mesodermal Commitment Pathway; Nucleotide Metabolism,Purine salvage,9,High,1
Q9H2D6-5,Isoform 1 of TRIO and F-actin-binding protein OS=Homo sapiens OX=9606 GN=TRIOBP,0,92.461,30,16,93,16,593,68,6.1,41664,2.15,14,3,cell division;cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytoskeleton;nucleus,protein binding;RNA binding,"Pf00169, Pf04514",11078,,TRIOBP,22,,,,0,High,1
Q9H0P0,Cytosolic 5'-nucleotidase 3A OS=Homo sapiens OX=9606 GN=NT5C3A PE=1 SV=3,0,92.453,43,13,100,1,336,37.9,7.12,35877,10.89,13,4,defense response;metabolic process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;mitochondrion,catalytic activity;metal ion binding;nucleotide binding,Pf05822,51251,ENSG00000122643.18,NT5C3; NT5C3A,7,Purine metabolism; Pyrimidine metabolism; Nicotinate and nicotinamide metabolism; Metabolic pathways,,Pyrimidine catabolism,8,High,1
O15372,Eukaryotic translation initiation factor 3 subunit H OS=Homo sapiens OX=9606 GN=EIF3H PE=1 SV=1,0,92.425,43,13,145,13,352,39.9,6.54,63080,0,13,1,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;membrane,protein binding;RNA binding,Pf01398,8667,ENSG00000147677.10,EIF3H,8,RNA transport; Measles,Translation Factors,"Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Ribosomal scanning and start codon recognition",14,High,1
Q8NDH3,Probable aminopeptidase NPEPL1 OS=Homo sapiens OX=9606 GN=NPEPL1 PE=1 SV=3,0,92.382,29,11,141,11,523,55.8,6.87,57274,,11,,metabolic process,cytoplasm;nucleus,catalytic activity;metal ion binding;protein binding,Pf00883,79716,ENSG00000215440.11,NPEPL1,20,,,,0,High,1
Q9P0S9,Transmembrane protein 14C OS=Homo sapiens OX=9606 GN=TMEM14C PE=1 SV=1,0,92.347,78,5,814,5,112,11.6,9.88,351694,2.79,4,3,metabolic process,membrane;mitochondrion,protein binding,Pf03647,51522,ENSG00000111843.13,TMEM14C,6,,,,0,High,1
Q9C0C9,(E3-independent) E2 ubiquitin-conjugating enzyme OS=Homo sapiens OX=9606 GN=UBE2O PE=1 SV=3,0,92.274,15,16,141,16,1292,141.2,5.12,54779,5.15,16,1,metabolic process;regulation of biological process;transport,cytoplasm;cytosol;nucleus,catalytic activity;nucleotide binding;protein binding;RNA binding,Pf00179,63893,ENSG00000175931.12,UBE2O,17,Ubiquitin mediated proteolysis,,Antigen processing: Ubiquitination & Proteasome degradation,5,High,1
P46063,ATP-dependent DNA helicase Q1 OS=Homo sapiens OX=9606 GN=RECQL PE=1 SV=3,0,92.261,29,16,98,16,649,73.4,7.88,40917,0,16,1,metabolic process;response to stimulus,chromosome;cytoplasm;membrane;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding,"Pf00270, Pf00271, Pf04851, Pf09382",5965,ENSG00000004700.15,RECQL,12,,,,0,High,1
Q99436,Proteasome subunit beta type-7 OS=Homo sapiens OX=9606 GN=PSMB7 PE=1 SV=1,0,92.215,41,11,279,11,277,29.9,7.68,125368,0,11,1,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;nucleus;organelle lumen;proteasome,catalytic activity;nucleotide binding;protein binding,"Pf00227, Pf12465",5695,ENSG00000136930.12,PSMB7,9,Proteasome,Proteasome Degradation,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Neutrophil degranulation; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,151,High,1
Q68EM7,Rho GTPase-activating protein 17 OS=Homo sapiens OX=9606 GN=ARHGAP17 PE=1 SV=1,0,92.209,24,15,132,15,881,95.4,7.62,56644,,15,,regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,enzyme regulator activity;protein binding,"Pf00620, Pf03114",55114,ENSG00000140750.16,ARHGAP17,16,,,Rho GTPase cycle,3,High,1
Q14694,Ubiquitin carboxyl-terminal hydrolase 10 OS=Homo sapiens OX=9606 GN=USP10 PE=1 SV=2,0,92.166,21,12,96,12,798,87.1,5.31,47954,,12,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endosome;nucleus,catalytic activity;protein binding;RNA binding,"Pf00443, Pf13423",9100,ENSG00000103194.15,USP10,16,,,Termination of translesion DNA synthesis; Ub-specific processing proteases,8,High,1
P61353,60S ribosomal protein L27 OS=Homo sapiens OX=9606 GN=RPL27 PE=1 SV=2,0,92.133,46,10,205,10,136,15.8,10.56,99717,0,10,2,cell organization and biogenesis;metabolic process;transport,cytosol;membrane;nucleus;ribosome,RNA binding;structural molecule activity,"Pf00467, Pf01777",6155,ENSG00000131469.12,RPL27,17,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
Q6ZT12,E3 ubiquitin-protein ligase UBR3 OS=Homo sapiens OX=9606 GN=UBR3 PE=2 SV=2,0,92.096,13,18,57,18,1888,212.3,6.1,24255,2.28,17,1,metabolic process;response to stimulus,cytoplasm;membrane,catalytic activity;metal ion binding,Pf02207,130507,ENSG00000144357.16,UBR3,2,,,,0,High,1
Q9NV70,Exocyst complex component 1 OS=Homo sapiens OX=9606 GN=EXOC1 PE=1 SV=4,0,92.011,23,13,74,13,894,101.9,6.61,29675,17.87,12,1,defense response;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane,protein binding,"Pf09763, Pf15277",55763,ENSG00000090989.17,EXOC1,4,,,Translocation of GLUT4 to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium,10,High,1
Q01105,Protein SET OS=Homo sapiens OX=9606 GN=SET PE=1 SV=3,0,91.943,47,11,167,11,290,33.5,4.32,73149,,11,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;endoplasmic reticulum;nucleus,DNA binding;enzyme regulator activity;protein binding,Pf00956,6418,ENSG00000119335.16,SET,9,,Histone Modifications,HuR (ELAVL1) binds and stabilizes mRNA; Condensation of Prophase Chromosomes,9,High,1
Q5R3I4,Tetratricopeptide repeat protein 38 OS=Homo sapiens OX=9606 GN=TTC38 PE=1 SV=1,0,91.907,42,13,88,13,469,52.8,5.99,41395,,13,,,,protein binding,,55020,ENSG00000075234.16,TTC38,22,,,,0,High,1
Q8WXF1,Paraspeckle component 1 OS=Homo sapiens OX=9606 GN=PSPC1 PE=1 SV=1,0,91.85,27,12,90,12,523,58.7,6.67,40899,,12,,defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,DNA binding;protein binding;RNA binding,"Pf00076, Pf08075, Pf13893, Pf14259",55269,ENSG00000121390.18,PSPC1,13,,,,0,High,1
Q9UPY8,Microtubule-associated protein RP/EB family member 3 OS=Homo sapiens OX=9606 GN=MAPRE3 PE=1 SV=1,0,91.817,51,15,183,12,281,32,5.54,80080,1.82,15,3,cell division;regulation of biological process,cytoplasm;cytoskeleton,protein binding,"Pf00307, Pf03271",22924,ENSG00000084764.10,MAPRE3,2,,,,0,High,1
O00505,Importin subunit alpha-4 OS=Homo sapiens OX=9606 GN=KPNA3 PE=1 SV=2,0,91.804,22,9,131,6,521,57.8,4.94,65995,0,9,1,cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytosol;nucleus,protein binding;transporter activity,"Pf00514, Pf01602, Pf01749, Pf13513, Pf13646",3839,ENSG00000102753.9,KPNA3,13,,,NS1 Mediated Effects on Host Pathways; ISG15 antiviral mechanism,10,High,1
P51610,Host cell factor 1 OS=Homo sapiens OX=9606 GN=HCFC1 PE=1 SV=2,0,91.76,17,19,92,18,2035,208.6,7.46,38715,0,19,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;membrane;nucleus,catalytic activity;protein binding,"Pf01344, Pf13415, Pf13418, Pf13854, Pf13964",3054,ENSG00000172534.13,HCFC1,X,Herpes simplex infection,Mitochondrial Gene Expression,Transcriptional activation of mitochondrial biogenesis; HATs acetylate histones; UCH proteinases,12,High,1
Q05193,Dynamin-1 OS=Homo sapiens OX=9606 GN=DNM1 PE=1 SV=2,0,91.718,15,15,177,2,864,97.3,7.17,73882,,15,,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;Golgi;membrane,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00169, Pf00350, Pf01031, Pf02212",1759,ENSG00000106976.20,DNM1,9,Endocrine and other factor-regulated calcium reabsorption; Bacterial invasion of epithelial cells; Synaptic vesicle cycle; Endocytosis; Phospholipase D signaling pathway,Synaptic Vesicle Pathway; Primary Focal Segmental Glomerulosclerosis FSGS; One carbon metabolism and related pathways; EGF/EGFR Signaling Pathway,EPH-ephrin mediated repulsion of cells; Formation of annular gap junctions; Retrograde neurotrophin signalling; Toll Like Receptor 4 (TLR4) Cascade; Clathrin-mediated endocytosis; MHC class II antigen presentation; Recycling pathway of L1,33,High,1
P23588,Eukaryotic translation initiation factor 4B OS=Homo sapiens OX=9606 GN=EIF4B PE=1 SV=2,0,91.678,17,11,292,11,611,69.1,5.73,124570,,11,,cell organization and biogenesis;metabolic process;regulation of biological process,cytosol,catalytic activity;protein binding;RNA binding,"Pf00076, Pf14259",1975,ENSG00000063046.17,EIF4B,12,RNA transport; Proteoglycans in cancer; PI3K-Akt signaling pathway; mTOR signaling pathway,Translation Factors; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Interferon type I signaling pathways,mTORC1-mediated signalling; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Deadenylation of mRNA; Ribosomal scanning and start codon recognition,22,High,1
P09543,"2',3'-cyclic-nucleotide 3'-phosphodiesterase OS=Homo sapiens OX=9606 GN=CNP PE=1 SV=2",0,91.642,30,14,100,14,421,47.5,9.07,37258,3.79,14,2,cell communication;cell differentiation;cell organization and biogenesis;metabolic process;response to stimulus,cytoplasm;membrane,catalytic activity;nucleotide binding;RNA binding,"Pf01591, Pf05881, Pf08302, Pf13207, Pf13671",1267,ENSG00000173786.16,CNP,17,,Glial Cell Differentiation; Mecp2 and Associated Rett Syndrome,,2,High,1
Q7Z4H8,Protein O-glucosyltransferase 3 OS=Homo sapiens OX=9606 GN=POGLUT3 PE=1 SV=2,0,91.609,33,13,84,13,507,58.5,8.24,39252,0,13,1,metabolic process,endoplasmic reticulum;organelle lumen,catalytic activity;protein binding,"Pf00630, Pf05686, Pf13524",143888,ENSG00000178202.12,KDELC2,11,,,,0,High,1
Q13620-1,Isoform 2 of Cullin-4B OS=Homo sapiens OX=9606 GN=CUL4B,0,91.548,20,16,151,7,895,102.2,7.94,66821,,16,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytosol,catalytic activity;DNA binding;protein binding,"Pf00888, Pf10557",8450,ENSG00000158290.16,CUL4B,X,,Mesodermal Commitment Pathway,,1,High,1
Q66K74,Microtubule-associated protein 1S OS=Homo sapiens OX=9606 GN=MAP1S PE=1 SV=2,0,91.425,19,13,79,13,1059,112.1,7.3,38618,,13,,cell death;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;nucleus,catalytic activity;DNA binding;protein binding,,55201,ENSG00000130479.10,MAP1S,19,,,,0,High,1
P54709,Sodium/potassium-transporting ATPase subunit beta-3 OS=Homo sapiens OX=9606 GN=ATP1B3 PE=1 SV=1,0,91.422,37,13,152,12,279,31.5,8.35,63518,,13,,cell organization and biogenesis;cellular component movement;cellular homeostasis;regulation of biological process;transport,cytoplasm;membrane,catalytic activity;enzyme regulator activity;protein binding;transporter activity,Pf00287,483,ENSG00000069849.10,ATP1B3,3,Salivary secretion; Thyroid hormone synthesis; Proximal tubule bicarbonate reclamation; cAMP signaling pathway; Carbohydrate digestion and absorption; Insulin secretion; Endocrine and other factor-regulated calcium reabsorption; Pancreatic secretion; Bile secretion; Mineral absorption; Adrenergic signaling in cardiomyocytes; Cardiac muscle contraction; Thyroid hormone signaling pathway; Gastric acid secretion; Protein digestion and absorption; Aldosterone-regulated sodium reabsorption; cGMP-PKG signaling pathway,Calcium Regulation in the Cardiac Cell,Ion homeostasis; Basigin interactions; Ion transport by P-type ATPases,27,High,1
Q9BW92,"Threonine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=TARS2 PE=1 SV=1",0,91.394,28,16,92,16,718,81,7.3,42810,0,16,1,metabolic process;regulation of biological process,cytoplasm;mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding,"Pf00587, Pf02824, Pf03129, Pf07973",80222,ENSG00000143374.16,TARS2,1,Aminoacyl-tRNA biosynthesis,,Mitochondrial tRNA aminoacylation,5,High,1
Q9Y5X3,Sorting nexin-5 OS=Homo sapiens OX=9606 GN=SNX5 PE=1 SV=1,0,91.378,45,15,94,15,404,46.8,6.76,44736,,15,,cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytosol;endosome;membrane,protein binding,"Pf00787, Pf09325",27131,ENSG00000089006.16,SNX5,20,Endocytosis,,Golgi Associated Vesicle Biogenesis,6,High,1
P21964,Catechol O-methyltransferase OS=Homo sapiens OX=9606 GN=COMT PE=1 SV=2,0,91.378,27,8,168,8,271,30,5.47,70482,0,8,1,cell communication;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;mitochondrion,catalytic activity;metal ion binding;protein binding,"Pf01596, Pf09445, Pf12847, Pf13578, Pf13659",1312,ENSG00000093010.13,COMT,22,Tyrosine metabolism; Steroid hormone biosynthesis; Dopaminergic synapse; Metabolic pathways,Dopamine metabolism; Biogenic Amine Synthesis; Estrogen metabolism; Metapathway biotransformation; Methylation Pathways,Enzymatic degradation of dopamine by COMT; Enzymatic degradation of Dopamine by monoamine oxidase; Methylation,19,High,1
P0DOY2,Immunoglobulin lambda constant 2 OS=Homo sapiens OX=9606 GN=IGLC2 PE=1 SV=1,0,91.326,56,9,564,1,106,11.3,7.24,250382,92.53,8,2,cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity;protein binding,"Pf07654, Pf13927",3538,,IGLC2,22,,,FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis,26,High,1
Q6IQ23,Pleckstrin homology domain-containing family A member 7 OS=Homo sapiens OX=9606 GN=PLEKHA7 PE=1 SV=2,0,91.31,22,17,47,17,1121,127.1,9.35,20899,4.85,16,2,cell organization and biogenesis;metabolic process,cytoplasm;cytoskeleton;cytosol;nucleus,catalytic activity;motor activity;protein binding,"Pf00169, Pf00397, Pf01576, Pf01920, Pf02463, Pf03961, Pf07798, Pf14992, Pf15409, Pf15413",144100,ENSG00000166689.15,PLEKHA7,11,,,,0,High,1
P08571,Monocyte differentiation antigen CD14 OS=Homo sapiens OX=9606 GN=CD14 PE=1 SV=2,0,91.274,27,9,105,9,375,40.1,6.23,51193,,9,,cell death;defense response;regulation of biological process;response to stimulus;transport,cell surface;extracellular;Golgi;membrane,protein binding;receptor activity;signal transducer activity,,929,ENSG00000170458.13,CD14,5,Phagosome; Hematopoietic cell lineage; Toll-like receptor signaling pathway; Tuberculosis; Amoebiasis; Transcriptional misregulation in cancer; MAPK signaling pathway; Legionellosis; Pathogenic Escherichia coli infection; Regulation of actin cytoskeleton; Salmonella infection; Pertussis; NF-kappa B signaling pathway,Regulation of toll-like receptor signaling pathway; Pathogenic Escherichia coli infection; MAPK Signaling Pathway; Regulation of Actin Cytoskeleton; Toll-like receptor signaling pathway,"MyD88:Mal cascade initiated on plasma membrane; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; IKK complex recruitment mediated by RIP1; Ligand-dependent caspase activation; IRAK4 deficiency (TLR2/4); ER-Phagosome pathway; TRAF6-mediated induction of TAK1 complex within TLR4 complex; Activated TLR4 signalling; Neutrophil degranulation; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; Regulation of TLR by endogenous ligand; TRIF-mediated programmed cell death; Transfer of LPS from LBP carrier to CD14; TICAM1,TRAF6-dependent induction of TAK1 complex; MyD88 deficiency (TLR2/4)",56,High,1
P06865,Beta-hexosaminidase subunit alpha OS=Homo sapiens OX=9606 GN=HEXA PE=1 SV=2,0,91.273,32,15,167,14,529,60.7,5.16,76915,2.51,15,3,metabolic process,membrane;organelle lumen;vacuole,catalytic activity;protein binding,"Pf00728, Pf14845",3073,ENSG00000213614.9,HEXA,15,Other glycan degradation; Glycosphingolipid biosynthesis - ganglio series; Glycosphingolipid biosynthesis - globo and isoglobo series; Amino sugar and nucleotide sugar metabolism; Lysosome; Metabolic pathways; Glycosaminoglycan degradation,,CS/DS degradation; Glycosphingolipid metabolism; Hyaluronan uptake and degradation; Keratan sulfate degradation,19,High,1
Q15056,Eukaryotic translation initiation factor 4H OS=Homo sapiens OX=9606 GN=EIF4H PE=1 SV=5,0,91.136,39,9,131,9,248,27.4,7.23,69049,,9,,cell organization and biogenesis;metabolic process;regulation of biological process;reproduction,cytoplasm;cytosol;membrane,catalytic activity;protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",7458,ENSG00000106682.14,EIF4H,7,,Translation Factors,L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition,10,High,1
O15031,Plexin-B2 OS=Homo sapiens OX=9606 GN=PLXNB2 PE=1 SV=3,0,90.958,12,16,82,15,1838,205,6.24,35725,,16,,cell proliferation;development;regulation of biological process;response to stimulus,cell surface;membrane,protein binding;receptor activity;signal transducer activity,"Pf01403, Pf01437, Pf01833, Pf08337",23654,ENSG00000196576.14,PLXNB2,22,Axon guidance,,,1,High,1
Q9BZ29,Dedicator of cytokinesis protein 9 OS=Homo sapiens OX=9606 GN=DOCK9 PE=1 SV=2,0,90.954,13,21,67,21,2069,236.3,7.49,25481,3.16,20,1,coagulation;regulation of biological process;response to stimulus,cytosol;membrane,protein binding,"Pf00169, Pf06920, Pf11878, Pf14429",23348,,DOCK9,13,,,Factors involved in megakaryocyte development and platelet production,2,High,1
Q8TB37,Iron-sulfur protein NUBPL OS=Homo sapiens OX=9606 GN=NUBPL PE=1 SV=3,0,90.878,44,10,224,10,319,34.1,9.04,109197,0,9,2,cell organization and biogenesis,membrane;mitochondrion;organelle lumen,metal ion binding;nucleotide binding,"Pf01656, Pf10609",80224,ENSG00000151413.16,NUBPL,14,,,Complex I biogenesis,5,High,1
Q8IZ83,Aldehyde dehydrogenase family 16 member A1 OS=Homo sapiens OX=9606 GN=ALDH16A1 PE=1 SV=2,0,90.798,21,12,77,12,802,85.1,6.79,33364,,12,,metabolic process,membrane,catalytic activity,"Pf00171, Pf07368",126133,ENSG00000161618.9,ALDH16A1,19,,,,0,High,1
O60502,Protein O-GlcNAcase OS=Homo sapiens OX=9606 GN=OGA PE=1 SV=2,0,90.716,22,16,114,15,916,102.8,4.91,48786,,16,,metabolic process,cytoplasm;cytosol;membrane;nucleus,catalytic activity,Pf07555,10724,ENSG00000198408.13,MGEA5,10,Insulin resistance,,,1,High,1
Q9H0P0-1,Isoform 1 of Cytosolic 5'-nucleotidase 3A OS=Homo sapiens OX=9606 GN=NT5C3A,0,90.675,48,13,96,1,297,33.9,5.86,33983,13.08,12,5,defense response;metabolic process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;mitochondrion,catalytic activity;metal ion binding;nucleotide binding,"Pf05822, Pf12710",51251,ENSG00000122643.18,NT5C3; NT5C3A,7,,,,0,High,1
Q9Y3A5,Ribosome maturation protein SBDS OS=Homo sapiens OX=9606 GN=SBDS PE=1 SV=4,0,90.626,40,11,266,11,250,28.7,8.75,119018,9.42,10,2,cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;response to stimulus,cytoplasm;cytoskeleton;cytosol;nucleus,protein binding;RNA binding,"Pf01172, Pf09377",51119,ENSG00000126524.9,SBDS,7,Ribosome biogenesis in eukaryotes,,,1,High,1
O60941,Dystrobrevin beta OS=Homo sapiens OX=9606 GN=DTNB PE=1 SV=1,0,90.609,26,13,140,7,627,71.3,7.91,56453,67.9,13,2,,cytoplasm,metal ion binding;protein binding,"Pf00569, Pf02403, Pf03962, Pf05400, Pf09068, Pf09069, Pf11932",1838,ENSG00000138101.18,DTNB,2,,,,0,High,1
Q8TD19,Serine/threonine-protein kinase Nek9 OS=Homo sapiens OX=9606 GN=NEK9 PE=1 SV=2,0,90.608,20,15,110,15,979,107.1,5.74,46750,2.94,15,1,cell division;cell organization and biogenesis;metabolic process,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf00415, Pf07714, Pf13540, Pf14531",91754,ENSG00000119638.12,NEK9,14,,,"Activation of NIMA Kinases NEK9, NEK6, NEK7; Nuclear Pore Complex (NPC) Disassembly",7,High,1
Q14166,Tubulin--tyrosine ligase-like protein 12 OS=Homo sapiens OX=9606 GN=TTLL12 PE=1 SV=2,0,90.498,34,16,77,16,644,74.4,5.53,27874,,16,,metabolic process,,catalytic activity;nucleotide binding,Pf03133,23170,ENSG00000100304.12,TTLL12,22,,,Carboxyterminal post-translational modifications of tubulin,3,High,1
Q6IQ22,Ras-related protein Rab-12 OS=Homo sapiens OX=9606 GN=RAB12 PE=1 SV=3,0,90.342,51,14,168,14,244,27.2,8.41,76020,0,14,1,metabolic process;regulation of biological process;response to stimulus;transport,cytosol;endosome;Golgi;membrane;vacuole,catalytic activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf01926, Pf08477",201475,ENSG00000206418.3,RAB12,18,,,RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation,7,High,1
P01042-2,Isoform LMW of Kininogen-1 OS=Homo sapiens OX=9606 GN=KNG1,0,90.264,22,9,241,1,427,47.9,6.65,108432,41.36,8,2,cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane;organelle lumen,enzyme regulator activity;metal ion binding;protein binding,Pf00031,3827,ENSG00000113889.11,KNG1,3,,ACE Inhibitor Pathway; Complement and Coagulation Cascades,,2,High,1
P05156,Complement factor I OS=Homo sapiens OX=9606 GN=CFI PE=1 SV=2,0,90.2,20,14,89,14,583,65.7,7.5,40431,,14,,defense response;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity;metal ion binding;protein binding;receptor activity,"Pf00057, Pf00089, Pf00530",3426,ENSG00000205403.12,CFI,4,Staphylococcus aureus infection; Complement and coagulation cascades,Complement and Coagulation Cascades,Regulation of Complement cascade,7,High,1
P08727,"Keratin, type I cytoskeletal 19 OS=Homo sapiens OX=9606 GN=KRT19 PE=1 SV=4",0,90.096,21,13,471,1,400,44.1,5.14,261224,0,13,2,cell death;cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus,cytoskeleton;cytosol;membrane,protein binding;structural molecule activity,Pf00038,3880,ENSG00000171345.13,KRT19,17,,,Formation of the cornified envelope,3,High,1
P19652,Alpha-1-acid glycoprotein 2 OS=Homo sapiens OX=9606 GN=ORM2 PE=1 SV=2,0,90.095,35,9,651,7,201,23.6,5.11,318073,,9,,defense response;regulation of biological process;response to stimulus;transport,extracellular;organelle lumen,,Pf00061,5005,ENSG00000228278.3,ORM2,9,,,Platelet degranulation ; Neutrophil degranulation,7,High,1
Q9H3K2,Growth hormone-inducible transmembrane protein OS=Homo sapiens OX=9606 GN=GHITM PE=1 SV=2,0,90.081,18,7,484,7,345,37.2,9.94,233574,0,7,2,cell death,membrane;mitochondrion,protein binding,,27069,ENSG00000165678.20,GHITM,10,,,,0,High,1
P55036,26S proteasome non-ATPase regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PSMD4 PE=1 SV=1,0,90.048,27,9,116,9,377,40.7,4.79,57319,0,9,2,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus;proteasome,catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding,"Pf02809, Pf04056, Pf13519",5710,ENSG00000159352.15,PSMD4,1,Proteasome; Epstein-Barr virus infection,Proteasome Degradation; Parkin-Ubiquitin Proteasomal System pathway,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,152,High,1
Q3ZCQ8,Mitochondrial import inner membrane translocase subunit TIM50 OS=Homo sapiens OX=9606 GN=TIMM50 PE=1 SV=2,0,90.014,29,7,199,7,353,39.6,8.37,102789,6.65,7,1,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion;nucleus,catalytic activity;protein binding;RNA binding,Pf03031,92609,ENSG00000105197.10,TIMM50,19,,,Mitochondrial protein import; Metabolism of proteins,2,High,1
Q00G26,Perilipin-5 OS=Homo sapiens OX=9606 GN=PLIN5 PE=1 SV=2,0,89.897,35,11,95,11,463,50.8,5.2,44995,27.8,10,2,cell organization and biogenesis;regulation of biological process,cytoplasm;cytosol;mitochondrion,protein binding,Pf03036,440503,ENSG00000214456.8,PLIN5,19,PPAR signaling pathway,,,1,High,1
Q14683,Structural maintenance of chromosomes protein 1A OS=Homo sapiens OX=9606 GN=SMC1A PE=1 SV=2,0,89.849,19,21,54,21,1233,143.1,7.64,23418,,21,,cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;cytosol;nucleus,nucleotide binding;protein binding;RNA binding,"Pf02463, Pf05262, Pf05557, Pf06470, Pf09726, Pf09731, Pf10186, Pf12128, Pf13175, Pf13304, Pf13476, Pf13555, Pf13558",8243,ENSG00000072501.17,SMC1A,X,Oocyte meiosis; Cell cycle,miRNA Regulation of DNA Damage Response; Cell Cycle; Retinoblastoma (RB) in Cancer; Constitutive Androstane Receptor Pathway; Pathways Affected in Adenoid Cystic Carcinoma; ATM Signaling Network in Development and Disease; mRNA Processing; DNA Damage Response,Meiotic synapsis; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin; Establishment of Sister Chromatid Cohesion; SUMOylation of DNA damage response and repair proteins,30,High,1
Q08378,Golgin subfamily A member 3 OS=Homo sapiens OX=9606 GN=GOLGA3 PE=1 SV=2,0,89.813,20,21,70,21,1498,167.3,5.44,25349,,21,,metabolic process;regulation of biological process;transport,cytoplasm;cytosol;Golgi;membrane;nucleus,catalytic activity;motor activity;protein binding;structural molecule activity;transporter activity,"Pf00038, Pf01576, Pf02463, Pf04111, Pf05557, Pf07888, Pf10186, Pf12128, Pf12325",2802,ENSG00000090615.14,GOLGA3,12,,,,0,High,1
Q9UI10,Translation initiation factor eIF-2B subunit delta OS=Homo sapiens OX=9606 GN=EIF2B4 PE=1 SV=2,0,89.576,35,13,115,13,523,57.5,9.38,46450,,13,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,protein binding;RNA binding,Pf01008,8890,ENSG00000115211.15,EIF2B4,2,RNA transport,Translation Factors,Recycling of eIF2:GDP,7,High,1
P08294,Extracellular superoxide dismutase [Cu-Zn] OS=Homo sapiens OX=9606 GN=SOD3 PE=1 SV=2,0,89.573,45,9,170,9,240,25.8,6.61,88707,0,9,1,metabolic process;response to stimulus,cytoplasm;extracellular;nucleus;organelle lumen,antioxidant activity;catalytic activity;metal ion binding;protein binding,Pf00080,6649,ENSG00000109610.5,SOD3,4,,Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism; NRF2 pathway; Copper homeostasis; One carbon metabolism and related pathways; Oxidative Stress,Detoxification of Reactive Oxygen Species,10,High,1
Q96EY8,Corrinoid adenosyltransferase OS=Homo sapiens OX=9606 GN=MMAB PE=1 SV=1,0,89.572,49,10,149,10,250,27.4,8.6,67659,1.83,10,2,metabolic process,mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding,Pf01923,326625,ENSG00000139428.11,MMAB,12,Metabolic pathways; Porphyrin and chlorophyll metabolism,Vitamin B12 Metabolism,"Cobalamin (Cbl, vitamin B12) transport and metabolism; Defective MMAB causes methylmalonic aciduria type cblB",12,High,1
Q96KP1,Exocyst complex component 2 OS=Homo sapiens OX=9606 GN=EXOC2 PE=1 SV=1,0,89.569,25,18,91,18,924,104,6.9,40089,,18,,cell organization and biogenesis;regulation of biological process;transport,cytosol;membrane,protein binding,"Pf01833, Pf15469",55770,ENSG00000112685.13,EXOC2,6,Ras signaling pathway,RalA downstream regulated genes,Translocation of GLUT4 to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium,12,High,1
Q15070,Mitochondrial inner membrane protein OXA1L OS=Homo sapiens OX=9606 GN=OXA1L PE=1 SV=3,0,89.549,19,9,332,9,435,48.5,9.45,142165,,9,,cell organization and biogenesis;metabolic process;regulation of biological process,membrane;mitochondrion,protein binding,Pf02096,5018,,OXA1L,14,Protein export,,,1,High,1
Q9NRG4,N-lysine methyltransferase SMYD2 OS=Homo sapiens OX=9606 GN=SMYD2 PE=1 SV=2,0,89.526,24,11,133,11,433,49.7,6.71,59818,37.92,8,3,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;protein binding,"Pf00856, Pf01753, Pf13424",56950,ENSG00000143499.13,SMYD2,1,,Histone Modifications,PKMTs methylate histone lysines; Regulation of TP53 Activity through Methylation,10,High,1
Q9UQM7,Calcium/calmodulin-dependent protein kinase type II subunit alpha OS=Homo sapiens OX=9606 GN=CAMK2A PE=1 SV=2,0,89.457,27,11,323,5,478,54.1,7.08,162261,0,11,1,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;mitochondrion;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf07714, Pf08332, Pf13474, Pf14534",815,ENSG00000070808.15,CAMK2A,5,Cholinergic synapse; Neurotrophin signaling pathway; Melanogenesis; Dopaminergic synapse; Adrenergic signaling in cardiomyocytes; GnRH signaling pathway; Long-term potentiation; Oocyte meiosis; Olfactory transduction; Wnt signaling pathway; cAMP signaling pathway; Amphetamine addiction; Tuberculosis; Insulin secretion; Inflammatory mediator regulation of TRP channels; Circadian entrainment; Aldosterone synthesis and secretion; Calcium signaling pathway; Axon guidance; Gastric acid secretion; Proteoglycans in cancer; Glucagon signaling pathway; Glioma; ErbB signaling pathway; Oxytocin signaling pathway; HIF-1 signaling pathway,B Cell Receptor Signaling Pathway; Corticotropin-releasing hormone signaling pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Common Pathways Underlying Drug Addiction; Myometrial Relaxation and Contraction Pathways; Melatonin metabolism and effects; Mecp2 and Associated Rett Syndrome; EGF/EGFR Signaling Pathway; Calcium Regulation in the Cardiac Cell; ErbB Signaling Pathway,"Ion homeostasis; HSF1-dependent transactivation; Interferon gamma signaling; Ca2+ pathway; Phase 0 - rapid depolarisation; Ras activation uopn Ca2+ infux through NMDA receptor; Ion transport by P-type ATPases; Unblocking of NMDA receptor, glutamate binding and activation; Trafficking of AMPA receptors; CREB phosphorylation through the activation of CaMKII; RAF/MAP kinase cascade; Interleukin-20 family signaling",71,High,1
Q86Y39,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 OS=Homo sapiens OX=9606 GN=NDUFA11 PE=1 SV=3,0,89.437,50,10,429,10,141,14.8,8.72,207684,23.73,9,5,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion,catalytic activity,,126328,ENSG00000174886.12,NDUFA11,19,Metabolic pathways; Huntington's disease; Oxidative phosphorylation; Parkinson's disease; Non-alcoholic fatty liver disease (NAFLD); Alzheimer's disease,Oxidative phosphorylation,Complex I biogenesis,12,High,1
Q9BRX8,Peroxiredoxin-like 2A OS=Homo sapiens OX=9606 GN=PRXL2A PE=1 SV=3,0,89.323,44,10,262,10,229,25.7,8.84,139736,2.04,10,2,metabolic process;regulation of biological process,cytoplasm;extracellular,antioxidant activity;catalytic activity,Pf13911,84293,ENSG00000122378.13,FAM213A,10,,,,0,High,1
O75347,Tubulin-specific chaperone A OS=Homo sapiens OX=9606 GN=TBCA PE=1 SV=3,0,89.306,54,12,155,12,108,12.8,5.29,76210,4.24,12,1,cell organization and biogenesis;metabolic process,cytoplasm;cytoskeleton,protein binding;RNA binding,Pf02970,6902,ENSG00000171530.13,TBCA,5,,,Post-chaperonin tubulin folding pathway,3,High,1
P01042,Kininogen-1 OS=Homo sapiens OX=9606 GN=KNG1 PE=1 SV=2,0,89.263,15,9,238,1,644,71.9,6.81,112477,0,9,1,cellular homeostasis;coagulation;defense response;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane;organelle lumen,enzyme regulator activity;metal ion binding;protein binding,Pf00031,3827,ENSG00000113889.11,KNG1,3,Complement and coagulation cascades,ACE Inhibitor Pathway; Complement and Coagulation Cascades,Platelet degranulation ; Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Peptide ligand-binding receptors; Gastrin-CREB signalling pathway via PKC and MAPK; G alpha (i) signalling events; Intrinsic Pathway of Fibrin Clot Formation,22,High,1
Q15120,"[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial OS=Homo sapiens OX=9606 GN=PDK3 PE=1 SV=1",0,89.227,36,14,100,10,406,46.9,8.37,42085,,14,,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding,"Pf02518, Pf10436",5165,ENSG00000067992.12,PDK3,X,,,Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid,8,High,1
Q9UI12,V-type proton ATPase subunit H OS=Homo sapiens OX=9606 GN=ATP6V1H PE=1 SV=1,0,89.227,34,12,80,12,483,55.8,6.48,38701,2.63,12,1,cellular homeostasis;regulation of biological process;response to stimulus;transport,cytosol;membrane,catalytic activity;enzyme regulator activity;protein binding;transporter activity,"Pf03224, Pf11698",51606,ENSG00000047249.17,ATP6V1H,8,Vibrio cholerae infection; Phagosome; Epithelial cell signaling in Helicobacter pylori infection; Oxidative phosphorylation; Tuberculosis; Rheumatoid arthritis; Metabolic pathways; mTOR signaling pathway; Lysosome; Synaptic vesicle cycle,,"ROS, RNS production in phagocytes; Ion channel transport; Insulin receptor recycling; Transferrin endocytosis and recycling; Nef Mediated CD8 Down-regulation; Nef Mediated CD4 Down-regulation",29,High,1
P36405,ADP-ribosylation factor-like protein 3 OS=Homo sapiens OX=9606 GN=ARL3 PE=1 SV=2,0,89.167,54,7,174,7,182,20.4,7.24,85358,,7,,cell division;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;Golgi;membrane;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,"Pf00009, Pf00025, Pf00071, Pf00503, Pf01926, Pf04670, Pf08477, Pf09439",403,ENSG00000138175.8,ARL3,10,,,Trafficking of myristoylated proteins to the cilium,4,High,1
Q15386,Ubiquitin-protein ligase E3C OS=Homo sapiens OX=9606 GN=UBE3C PE=1 SV=3,0,89.109,22,18,65,18,1083,123.8,6.71,24535,,18,,metabolic process,cytoplasm;nucleus;proteasome,catalytic activity;protein binding,Pf00632,9690,ENSG00000009335.17,UBE3C,7,Ubiquitin mediated proteolysis,,Antigen processing: Ubiquitination & Proteasome degradation,5,High,1
Q9H269,Vacuolar protein sorting-associated protein 16 homolog OS=Homo sapiens OX=9606 GN=VPS16 PE=1 SV=2,0,88.998,24,14,73,13,839,94.6,6.77,31054,,14,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;endosome;membrane;vacuole,protein binding,"Pf04840, Pf04841",64601,ENSG00000215305.9,VPS16,20,,,,0,High,1
P45985,Dual specificity mitogen-activated protein kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP2K4 PE=1 SV=1,0,88.978,41,10,70,10,399,44.3,8.07,28891,1.64,10,1,cell death;cell growth;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf07714, Pf14531",6416,ENSG00000065559.14,MAP2K4,17,Chagas disease (American trypanosomiasis); Influenza A; Toll-like receptor signaling pathway; Hepatitis B; GnRH signaling pathway; ErbB signaling pathway; Epstein-Barr virus infection; Epithelial cell signaling in Helicobacter pylori infection; TNF signaling pathway; Fc epsilon RI signaling pathway; HTLV-I infection; MAPK signaling pathway,Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; Signaling Pathways in Glioblastoma; TNF alpha Signaling Pathway; PDGF Pathway; Apoptosis; Structural Pathway of Interleukin 1 (IL-1); Cardiac Hypertrophic Response; Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation; IL-6 signaling pathway; TGF-beta Signaling Pathway; Association Between Physico-Chemical Features and Toxicity Associated Pathways; MAPK Signaling Pathway; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; Oxidative Damage; Wnt Signaling Pathway and Pluripotency; p38 MAPK Signaling Pathway; MAPK Cascade; Insulin Signaling; Toll-like receptor signaling pathway,Uptake and function of anthrax toxins; MAP3K8 (TPL2)-dependent MAPK1/3 activation; FCERI mediated MAPK activation; Activated TLR4 signalling; Interleukin-1 family signaling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; Oxidative Stress Induced Senescence,70,High,1
Q13576,Ras GTPase-activating-like protein IQGAP2 OS=Homo sapiens OX=9606 GN=IQGAP2 PE=1 SV=4,0,88.853,18,22,126,18,1575,180.5,5.64,48509,,22,,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;cytoskeleton;cytosol;membrane,enzyme regulator activity;protein binding,"Pf00307, Pf00616, Pf03836",10788,ENSG00000145703.15,IQGAP2,5,Regulation of actin cytoskeleton,G13 Signaling Pathway,RHO GTPases activate IQGAPs; Neutrophil degranulation,9,High,1
P22352,Glutathione peroxidase 3 OS=Homo sapiens OX=9606 GN=GPX3 PE=1 SV=2,0,88.832,28,8,671,8,226,25.5,8.13,345832,0,8,1,cell organization and biogenesis;metabolic process;response to stimulus,extracellular,antioxidant activity;catalytic activity;protein binding,Pf00255,2878,ENSG00000211445.11,GPX3,5,Arachidonic acid metabolism; Thyroid hormone synthesis; Glutathione metabolism,Glutathione metabolism; Selenium Micronutrient Network; Folate Metabolism; Selenium Metabolism and Selenoproteins; NRF2 pathway; One carbon metabolism and related pathways; Oxidative Stress; Metapathway biotransformation,Detoxification of Reactive Oxygen Species,14,High,1
Q9HBH5,Retinol dehydrogenase 14 OS=Homo sapiens OX=9606 GN=RDH14 PE=1 SV=1,0,88.626,29,8,171,8,336,36.8,8.79,90403,,8,,cell differentiation;metabolic process,endoplasmic reticulum;membrane;mitochondrion;nucleus,catalytic activity,"Pf00106, Pf01488, Pf08659, Pf13460",57665,ENSG00000240857.1,RDH14,2,,,RA biosynthesis pathway,4,High,1
P56181-2,"Isoform 2 of NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFV3",0,88.524,18,10,124,2,473,51,9.17,55445,6.68,8,2,cell organization and biogenesis;metabolic process,membrane;mitochondrion,catalytic activity;RNA binding,,4731,ENSG00000160194.17,NDUFV3,21,,Electron Transport Chain; Oxidative phosphorylation,,2,High,1
Q14444,Caprin-1 OS=Homo sapiens OX=9606 GN=CAPRIN1 PE=1 SV=2,0,88.414,29,11,64,11,709,78.3,5.25,26768,,11,,cell differentiation;regulation of biological process,cytoplasm;cytosol;membrane,protein binding;RNA binding,Pf12287,4076,ENSG00000135387.20,CAPRIN1,11,,,,0,High,1
Q13217,DnaJ homolog subfamily C member 3 OS=Homo sapiens OX=9606 GN=DNAJC3 PE=1 SV=1,0,88.39,38,14,100,14,504,57.5,6.15,38967,,14,,defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;extracellular;membrane;organelle lumen,enzyme regulator activity;protein binding,"Pf00226, Pf00515, Pf12569, Pf13371, Pf13414, Pf13432, Pf14559",5611,ENSG00000102580.14,DNAJC3,13,Influenza A; Protein processing in endoplasmic reticulum,Photodynamic therapy-induced unfolded protein response,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Viral mRNA Translation; Neutrophil degranulation; XBP1(S) activates chaperone genes,19,High,1
O94760,"N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 OS=Homo sapiens OX=9606 GN=DDAH1 PE=1 SV=3",0,88.21,42,11,130,10,285,31.1,5.81,59782,0,11,1,metabolic process;regulation of biological process;response to stimulus,cytosol;mitochondrion,catalytic activity;metal ion binding,Pf02274,23576,ENSG00000153904.18,DDAH1,1,,Mesodermal Commitment Pathway,eNOS activation,5,High,1
Q9UP95,Solute carrier family 12 member 4 OS=Homo sapiens OX=9606 GN=SLC12A4 PE=1 SV=2,0,88.191,19,18,82,12,1085,120.6,6.44,37260,0,18,1,cell communication;cellular homeostasis;transport,membrane,protein binding;transporter activity,"Pf00324, Pf13520",6560,ENSG00000124067.16,SLC12A4,16,,,Cation-coupled Chloride cotransporters,4,High,1
Q63HM9,PI-PLC X domain-containing protein 3 OS=Homo sapiens OX=9606 GN=PLCXD3 PE=2 SV=2,0,88.173,31,7,146,7,321,36.3,6.29,62547,39.42,6,3,metabolic process;regulation of biological process;response to stimulus,cytoplasm,catalytic activity;signal transducer activity,Pf00388,345557,ENSG00000182836.9,PLCXD3,5,,Ectoderm Differentiation,,1,High,1
O43237,Cytoplasmic dynein 1 light intermediate chain 2 OS=Homo sapiens OX=9606 GN=DYNC1LI2 PE=1 SV=1,0,88.099,34,12,121,12,492,54.1,6.38,58449,6.39,11,1,cell organization and biogenesis;cellular component movement;response to stimulus;transport,chromosome;cytoplasm;cytoskeleton;cytosol;endosome;membrane;vacuole,catalytic activity;motor activity;nucleotide binding;protein binding,Pf05783,1783,ENSG00000135720.12,DYNC1LI2,16,Salmonella infection; Vasopressin-regulated water reabsorption; Phagosome,,COPI-independent Golgi-to-ER retrograde traffic; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR),36,High,1
Q99459,Cell division cycle 5-like protein OS=Homo sapiens OX=9606 GN=CDC5L PE=1 SV=2,0,88.008,27,17,89,17,802,92.2,8.18,36335,0,17,1,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;membrane;nucleus;spliceosomal complex,DNA binding;protein binding;RNA binding,"Pf00249, Pf11831, Pf13921",988,ENSG00000096401.7,CDC5L,6,Spliceosome,,mRNA Splicing - Major Pathway,5,High,1
Q9P265,Disco-interacting protein 2 homolog B OS=Homo sapiens OX=9606 GN=DIP2B PE=1 SV=3,0,87.972,14,18,72,15,1576,171.4,8.09,30812,0,18,1,metabolic process,cytoplasm;membrane;nucleus,catalytic activity,"Pf00501, Pf06464",57609,ENSG00000066084.12,DIP2B,12,,,,0,High,1
Q9BYV2,Tripartite motif-containing protein 54 OS=Homo sapiens OX=9606 GN=TRIM54 PE=1 SV=3,0,87.951,37,7,99,5,358,40.3,5.22,23409,177.86,2,5,cell differentiation;development;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton,metal ion binding;protein binding;signal transducer activity,"Pf00097, Pf13445, Pf13639, Pf13923, Pf14634, Pf14835, Pf15227",57159,ENSG00000138100.13,TRIM54,2,,,,0,High,1
Q9C0E2,Exportin-4 OS=Homo sapiens OX=9606 GN=XPO4 PE=1 SV=2,0,87.949,15,15,56,15,1151,130.1,5.05,29901,,15,,regulation of biological process;transport,cytoplasm;cytosol;nucleus,protein binding;transporter activity,,64328,ENSG00000132953.16,XPO4,13,,eIF5A regulation in response to inhibition of the nuclear export system,,1,High,1
P78560,Death domain-containing protein CRADD OS=Homo sapiens OX=9606 GN=CRADD PE=1 SV=1,0,87.902,35,6,116,6,199,22.7,6.8,59277,,6,,cell death;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,protein binding,"Pf00531, Pf00619",8738,ENSG00000169372.12,CRADD,12,,Apoptosis,TP53 Regulates Transcription of Caspase Activators and Caspases,7,High,1
Q8IYQ7,Threonine synthase-like 1 OS=Homo sapiens OX=9606 GN=THNSL1 PE=1 SV=2,0,87.881,27,13,112,13,743,83,7.12,43563,,13,,,,nucleotide binding,"Pf00004, Pf00291, Pf01202, Pf13207, Pf13238, Pf13671, Pf14821",79896,ENSG00000185875.12,THNSL1,10,,,,0,High,1
Q9H511,Kelch-like protein 31 OS=Homo sapiens OX=9606 GN=KLHL31 PE=2 SV=1,0,87.863,22,10,54,10,634,70.2,6.73,4469,150.65,2,8,metabolic process;regulation of biological process,,catalytic activity;protein binding,"Pf00651, Pf01344, Pf07250, Pf07646, Pf07707, Pf07893, Pf13360, Pf13415, Pf13418, Pf13964",401265,ENSG00000124743.5,KLHL31,6,,,,0,High,1
Q969X5,Endoplasmic reticulum-Golgi intermediate compartment protein 1 OS=Homo sapiens OX=9606 GN=ERGIC1 PE=1 SV=1,0,87.762,41,9,126,9,290,32.6,7.06,51726,0,9,1,transport,endoplasmic reticulum;Golgi;membrane,protein binding,"Pf07970, Pf13850",57222,ENSG00000113719.15,ERGIC1,5,,,,0,High,1
Q13630,GDP-L-fucose synthase OS=Homo sapiens OX=9606 GN=TSTA3 PE=1 SV=1,0,87.759,39,8,77,8,321,35.9,6.6,36670,3.85,8,2,metabolic process,cytoplasm;cytosol,catalytic activity;protein binding,"Pf01073, Pf01370, Pf02719, Pf04321",7264,ENSG00000278243.2; ENSG00000104522.15,TSTA3,8; CHR_HSCHR8_3_CTG7,Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Fructose and mannose metabolism,,GDP-fucose biosynthesis,9,High,1
P53990,IST1 homolog OS=Homo sapiens OX=9606 GN=IST1 PE=1 SV=1,0,87.721,52,10,95,10,364,39.7,5.35,37384,10.8,8,3,cell division;cell organization and biogenesis;regulation of biological process;transport,chromosome;cytoplasm;cytoskeleton;cytosol;extracellular;nucleus;organelle lumen,protein binding,Pf03398,9798,,IST1,16,Endocytosis,,Neutrophil degranulation,4,High,1
Q9HCU5,Prolactin regulatory element-binding protein OS=Homo sapiens OX=9606 GN=PREB PE=1 SV=2,0,87.643,41,10,75,10,417,45.4,7.88,33112,,10,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,endoplasmic reticulum;membrane;nucleus,DNA binding;enzyme regulator activity;protein binding,Pf00400,10113,ENSG00000138073.13,PREB,2,Protein processing in endoplasmic reticulum,,XBP1(S) activates chaperone genes; Cargo concentration in the ER; COPII (Coat Protein 2) Mediated Vesicle Transport,13,High,1
P33527,Multidrug resistance-associated protein 1 OS=Homo sapiens OX=9606 GN=ABCC1 PE=1 SV=3,0,87.642,16,17,58,17,1531,171.5,7.11,25350,,17,,cell organization and biogenesis;cellular component movement;metabolic process;response to stimulus;transport,membrane,catalytic activity;nucleotide binding;transporter activity,"Pf00005, Pf00664",4363,ENSG00000278183.4; ENSG00000103222.18,ABCC1,16; CHR_HSCHR16_1_CTG1,Sphingolipid signaling pathway; ABC transporters; MicroRNAs in cancer; Vitamin digestion and absorption; Antifolate resistance,Irinotecan Pathway,"Cobalamin (Cbl, vitamin B12) transport and metabolism; Synthesis of Leukotrienes (LT) and Eoxins (EX); ABC-family proteins mediated transport",16,High,1
Q969G5,Caveolae-associated protein 3 OS=Homo sapiens OX=9606 GN=CAVIN3 PE=1 SV=3,0,87.609,31,8,353,8,261,27.7,6.43,164906,2.29,8,2,cell organization and biogenesis;regulation of biological process,cytoplasm;cytosol;membrane,protein binding,Pf15237,112464,ENSG00000170955.9,PRKCDBP; CAVIN3,11,,,,0,High,1
P03905,NADH-ubiquinone oxidoreductase chain 4 OS=Homo sapiens OX=9606 GN=MT-ND4 PE=1 SV=1,0,87.483,22,8,258,8,459,51.5,9.35,132201,6.94,7,2,cell organization and biogenesis;metabolic process;response to stimulus;transport,membrane;mitochondrion,catalytic activity,Pf00361,4538,ENSG00000198886.2,ND4,MT,Parkinson's disease; Oxidative phosphorylation; Metabolic pathways,Electron Transport Chain; Oxidative phosphorylation,Complex I biogenesis,10,High,1
Q9NQG5,Regulation of nuclear pre-mRNA domain-containing protein 1B OS=Homo sapiens OX=9606 GN=RPRD1B PE=1 SV=1,0,87.46,41,10,85,8,326,36.9,5.97,40018,,10,,metabolic process;regulation of biological process,cytosol;nucleus,protein binding,Pf04818,58490,ENSG00000101413.11,RPRD1B,20,,,RNA polymerase II transcribes snRNA genes,3,High,1
Q52LJ0,Protein FAM98B OS=Homo sapiens OX=9606 GN=FAM98B PE=1 SV=2,0,87.408,30,9,88,7,433,45.5,8.69,41409,,9,,,,,,,,,,,,,0,High,1
P15374,Ubiquitin carboxyl-terminal hydrolase isozyme L3 OS=Homo sapiens OX=9606 GN=UCHL3 PE=1 SV=1,0,87.288,56,9,225,9,230,26.2,4.92,96554,6.09,9,2,metabolic process,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,Pf01088,7347,ENSG00000118939.17,UCHL3,13,,Proteasome Degradation,Synthesis of active ubiquitin: roles of E1 and E2 enzymes; UCH proteinases; Neddylation,8,High,1
Q330K2,"NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 OS=Homo sapiens OX=9606 GN=NDUFAF6 PE=1 SV=2",0,87.195,29,9,126,8,333,38.2,9.36,55227,14.45,7,3,cell organization and biogenesis;metabolic process,cytoplasm;membrane;mitochondrion;nucleus,catalytic activity,Pf00494,137682,ENSG00000156170.12,NDUFAF6,8,,,Complex I biogenesis,5,High,1
Q8N4T8,Carbonyl reductase family member 4 OS=Homo sapiens OX=9606 GN=CBR4 PE=1 SV=3,0,87.173,37,7,189,7,237,25.3,9.33,86803,4.64,6,2,cell organization and biogenesis;metabolic process,mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding,"Pf00106, Pf08659, Pf13561",84869,ENSG00000145439.11,CBR4,4,,,Fatty acyl-CoA biosynthesis,4,High,1
Q27J81,Inverted formin-2 OS=Homo sapiens OX=9606 GN=INF2 PE=1 SV=2,0,87.1,19,16,45,16,1249,135.5,5.38,21723,,16,,cell organization and biogenesis;regulation of biological process,cytoplasm,protein binding,"Pf02181, Pf06367, Pf06371",64423,ENSG00000203485.12,INF2,14,,Primary Focal Segmental Glomerulosclerosis FSGS,,1,High,1
Q9NPH2,Inositol-3-phosphate synthase 1 OS=Homo sapiens OX=9606 GN=ISYNA1 PE=1 SV=1,0,87.099,30,12,154,12,558,61,5.76,65145,1.99,12,1,metabolic process,cytoplasm;cytosol,catalytic activity;protein binding,"Pf01658, Pf07994",51477,ENSG00000105655.18,ISYNA1,19,Metabolic pathways; Inositol phosphate metabolism,,"Synthesis of IP2, IP, and Ins in the cytosol",5,High,1
P61313,60S ribosomal protein L15 OS=Homo sapiens OX=9606 GN=RPL15 PE=1 SV=2,0,87.098,42,12,270,12,204,24.1,11.62,125774,0,12,2,cell organization and biogenesis;metabolic process;response to stimulus;transport,cytosol;membrane;nucleus;ribosome,protein binding;RNA binding;structural molecule activity,Pf00827,6138,ENSG00000174748.18,RPL15,3,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
Q15293,Reticulocalbin-1 OS=Homo sapiens OX=9606 GN=RCN1 PE=1 SV=1,0,87.068,57,13,84,13,331,38.9,5,32706,,13,,metabolic process,endoplasmic reticulum;organelle lumen,metal ion binding;protein binding,Pf13499,5954,ENSG00000049449.8,RCN1,11,,,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs),4,High,1
Q5XKE5,"Keratin, type II cytoskeletal 79 OS=Homo sapiens OX=9606 GN=KRT79 PE=1 SV=2",0,87.043,12,12,525,1,535,57.8,7.2,260040,2.3,12,1,cell death,cytosol,protein binding;structural molecule activity,"Pf00038, Pf09726, Pf12128, Pf13166",338785,ENSG00000185640.5,KRT79,12,,,Formation of the cornified envelope,3,High,1
O75694,Nuclear pore complex protein Nup155 OS=Homo sapiens OX=9606 GN=NUP155 PE=1 SV=1,0,86.947,17,16,90,16,1391,155.1,6.16,34535,0,16,1,cell organization and biogenesis;metabolic process;regulation of biological process;transport,membrane;nucleus,protein binding;structural molecule activity;transporter activity,"Pf03177, Pf08801",9631,ENSG00000113569.15,NUP155,5,RNA transport,,Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins,64,High,1
P62269,40S ribosomal protein S18 OS=Homo sapiens OX=9606 GN=RPS18 PE=1 SV=3,0,86.946,47,11,550,11,152,17.7,10.99,269615,1.65,11,2,cell organization and biogenesis;metabolic process;transport,cytoplasm;cytosol;membrane;nucleus;ribosome,protein binding;RNA binding;structural molecule activity,Pf00416,6222,ENSG00000223367.6; ENSG00000096150.9; ENSG00000235650.6; ENSG00000226225.6; ENSG00000231500.6,RPS18,6; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_MCF_CTG1,Ribosome,Cytoplasmic Ribosomal Proteins,"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane",38,High,1
Q13131,5'-AMP-activated protein kinase catalytic subunit alpha-1 OS=Homo sapiens OX=9606 GN=PRKAA1 PE=1 SV=4,0,86.713,25,11,100,9,559,64,8.12,41919,,11,,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf07714, Pf14531",5562,ENSG00000132356.11,PRKAA1,5,Insulin signaling pathway; PI3K-Akt signaling pathway; Circadian rhythm; Glucagon signaling pathway; Adipocytokine signaling pathway; mTOR signaling pathway; FoxO signaling pathway; Autophagy; Longevity regulating pathway - multiple species; Non-alcoholic fatty liver disease (NAFLD); Hypertrophic cardiomyopathy (HCM); AMPK signaling pathway; Longevity regulating pathway; Oxytocin signaling pathway; Insulin resistance,AMP-activated Protein Kinase (AMPK) Signaling; Target Of Rapamycin (TOR) Signaling; Energy Metabolism; Sterol Regulatory Element-Binding Proteins (SREBP) signalling; SREBF and miR33 in cholesterol and lipid homeostasis; Leptin signaling pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; mir-124 predicted interactions with cell cycle and differentiation; ATM Signaling Network in Development and Disease; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Leptin and adiponectin; Insulin Signaling,Energy dependent regulation of mTOR by LKB1-AMPK; TP53 Regulates Metabolic Genes; Regulation of TP53 Activity through Phosphorylation; Macroautophagy,41,High,1
Q8IUZ5,5-phosphohydroxy-L-lysine phospho-lyase OS=Homo sapiens OX=9606 GN=PHYKPL PE=1 SV=1,0,86.647,41,12,102,12,450,49.7,6.76,48263,14.81,12,2,metabolic process,mitochondrion;organelle lumen,catalytic activity;protein binding,Pf00202,85007,ENSG00000175309.14,AGXT2L2; PHYKPL,5,Lysine degradation; Metabolic pathways,,Collagen degradation; Lysine catabolism,9,High,1
Q32MZ4-4,Isoform 4 of Leucine-rich repeat flightless-interacting protein 1 OS=Homo sapiens OX=9606 GN=LRRFIP1,0,86.641,25,13,64,7,640,73,5.95,15964,69.3,6,7,metabolic process;regulation of biological process,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,DNA binding;protein binding;RNA binding,"Pf04111, Pf07888, Pf08385, Pf09738, Pf12128, Pf13654",9208,ENSG00000124831.18,LRRFIP1,2,,,,0,High,1
P62263,40S ribosomal protein S14 OS=Homo sapiens OX=9606 GN=RPS14 PE=1 SV=3,0,86.457,38,9,245,9,151,16.3,10.05,111331,,9,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytosol;membrane;mitochondrion;ribosome,protein binding;RNA binding;structural molecule activity;translation regulator activity,Pf00411,6208,ENSG00000164587.11,RPS14,5,Ribosome,Cytoplasmic Ribosomal Proteins,"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane",39,High,1
Q9BUR5,MICOS complex subunit MIC26 OS=Homo sapiens OX=9606 GN=APOO PE=1 SV=1,0,86.39,50,7,203,7,198,22.3,9.13,102705,49.29,5,5,cell organization and biogenesis;transport,cytosol;endoplasmic reticulum;extracellular;Golgi;membrane;mitochondrion,protein binding,Pf09769,79135,ENSG00000184831.13,APOO,X,,,Cristae formation,3,High,1
O95747,Serine/threonine-protein kinase OSR1 OS=Homo sapiens OX=9606 GN=OXSR1 PE=1 SV=1,0,86.302,29,12,153,10,527,58,6.43,74396,0,12,1,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf07714, Pf12202",9943,ENSG00000172939.8,OXSR1,3,,,,0,High,1
O15371,Eukaryotic translation initiation factor 3 subunit D OS=Homo sapiens OX=9606 GN=EIF3D PE=1 SV=1,0,86.257,28,15,110,15,548,63.9,6.05,46078,,15,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;membrane,protein binding;RNA binding,Pf05091,8664,ENSG00000100353.17,EIF3D,22,RNA transport,Translation Factors,"Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Ribosomal scanning and start codon recognition",13,High,1
P09871,Complement C1s subcomponent OS=Homo sapiens OX=9606 GN=C1S PE=1 SV=1,0,86.1,20,10,99,10,688,76.6,4.96,40940,2.09,10,2,defense response;metabolic process;regulation of biological process;response to stimulus,extracellular,catalytic activity;metal ion binding;protein binding,"Pf00084, Pf00089, Pf00431, Pf07645, Pf14670",716,ENSG00000182326.14,C1S,12,Staphylococcus aureus infection; Complement and coagulation cascades; Systemic lupus erythematosus; Pertussis,Oxidative Damage; Complement Activation; Complement and Coagulation Cascades,Regulation of Complement cascade; Classical antibody-mediated complement activation,14,High,1
Q9H9A6,Leucine-rich repeat-containing protein 40 OS=Homo sapiens OX=9606 GN=LRRC40 PE=1 SV=1,0,85.944,31,15,82,15,602,68.2,6.43,37677,,15,,regulation of biological process;response to stimulus,membrane,protein binding,"Pf12799, Pf13855",55631,ENSG00000066557.5,LRRC40,1,,,,0,High,1
Q93084,Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 OS=Homo sapiens OX=9606 GN=ATP2A3 PE=1 SV=2,0,85.93,9,10,528,2,1043,113.9,5.57,267119,33.72,8,3,transport,endoplasmic reticulum;membrane;nucleus,catalytic activity;metal ion binding;nucleotide binding;transporter activity,"Pf00122, Pf00689, Pf00690, Pf00702, Pf08282, Pf12710, Pf13246",489,ENSG00000074370.17,ATP2A3,17,cGMP-PKG signaling pathway; Alzheimer's disease; Calcium signaling pathway; Pancreatic secretion,Alzheimers Disease; Myometrial Relaxation and Contraction Pathways; Calcium Regulation in the Cardiac Cell,Ion homeostasis; Pre-NOTCH Processing in Golgi; Ion transport by P-type ATPases; Reduction of cytosolic Ca++ levels,21,High,1
P29474,"Nitric oxide synthase, endothelial OS=Homo sapiens OX=9606 GN=NOS3 PE=1 SV=4",0,85.922,15,15,62,15,1203,133.2,7.27,28350,0,15,1,,,,,,,,,,,,0,High,1
Q01546,"Keratin, type II cytoskeletal 2 oral OS=Homo sapiens OX=9606 GN=KRT76 PE=1 SV=2",0,85.903,11,13,408,1,638,65.8,8.12,209534,,13,,cell death;cell organization and biogenesis,cytosol;nucleus,structural molecule activity,"Pf00038, Pf11559",51350,ENSG00000185069.2,KRT76,12,,,Formation of the cornified envelope,3,High,1
Q4G0N4,"NAD kinase 2, mitochondrial OS=Homo sapiens OX=9606 GN=NADK2 PE=1 SV=2",0,85.828,43,16,83,16,442,49.4,8.18,36616,0,16,1,metabolic process,mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding,"Pf00781, Pf01513",133686,ENSG00000152620.12,NADK2; NADKD1,5,Nicotinate and nicotinamide metabolism; Metabolic pathways,,Nicotinate metabolism,6,High,1
P15880,40S ribosomal protein S2 OS=Homo sapiens OX=9606 GN=RPS2 PE=1 SV=2,0,85.827,37,11,331,11,293,31.3,10.24,161663,3.84,11,1,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytosol;membrane;nucleus;ribosome,protein binding;RNA binding;structural molecule activity,"Pf00333, Pf03719",6187,ENSG00000140988.15,RPS2,16,Ribosome,Cytoplasmic Ribosomal Proteins,"Peptide chain elongation; Protein methylation; Eukaryotic Translation Termination; Viral mRNA Translation; RMTs methylate histone arginines; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane",44,High,1
P48556,26S proteasome non-ATPase regulatory subunit 8 OS=Homo sapiens OX=9606 GN=PSMD8 PE=1 SV=2,0,85.827,36,11,258,11,350,39.6,9.7,110839,,11,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;nucleus;proteasome,catalytic activity,"Pf03399, Pf10075",5714,ENSG00000099341.11,PSMD8,19,Epstein-Barr virus infection; Proteasome,Proteasome Degradation; Parkin-Ubiquitin Proteasomal System pathway,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,152,High,1
P53370,Nucleoside diphosphate-linked moiety X motif 6 OS=Homo sapiens OX=9606 GN=NUDT6 PE=1 SV=2,0,85.803,41,11,95,11,316,35.7,8,42451,,11,,regulation of biological process,cytoplasm;mitochondrion;nucleus,catalytic activity;protein binding,Pf00293,11162,ENSG00000170917.13,NUDT6,4,,,,0,High,1
Q96HE7,ERO1-like protein alpha OS=Homo sapiens OX=9606 GN=ERO1A PE=1 SV=2,0,85.8,31,13,103,11,468,54.4,5.68,45445,,13,,cell death;cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;membrane;organelle lumen,catalytic activity;protein binding,Pf04137,30001,ENSG00000197930.12,ERO1L; ERO1A,14,Vibrio cholerae infection; Protein processing in endoplasmic reticulum,,Insulin processing; Detoxification of Reactive Oxygen Species,8,High,1
P35858,Insulin-like growth factor-binding protein complex acid labile subunit OS=Homo sapiens OX=9606 GN=IGFALS PE=1 SV=1,0,85.746,32,15,76,15,605,66,6.79,31692,,15,,metabolic process;regulation of biological process;response to stimulus,extracellular,protein binding,Pf13855,3483,ENSG00000099769.5,IGFALS,16,,,Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs),2,High,1
Q86UX2,Inter-alpha-trypsin inhibitor heavy chain H5 OS=Homo sapiens OX=9606 GN=ITIH5 PE=2 SV=2,0,85.709,22,14,83,14,942,104.5,8.28,31302,0,14,1,metabolic process;regulation of biological process,extracellular,enzyme regulator activity,"Pf00092, Pf06668, Pf08487, Pf10138, Pf13519, Pf13768",80760,,ITIH5,10,,,,0,High,1
Q9UNH7,Sorting nexin-6 OS=Homo sapiens OX=9606 GN=SNX6 PE=1 SV=1,0,85.639,35,14,119,14,406,46.6,6.16,55427,,14,,cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytosol;endosome;membrane;nucleus,protein binding,"Pf00787, Pf03114, Pf09325",58533,,SNX6,14,Endocytosis,,,1,High,1
O00567,Nucleolar protein 56 OS=Homo sapiens OX=9606 GN=NOP56 PE=1 SV=4,0,85.631,24,12,77,12,594,66,9.19,35795,,12,,metabolic process,cytoplasm;membrane;nucleus,protein binding;RNA binding,"Pf01798, Pf08060, Pf08156",10528,ENSG00000101361.16,NOP56,20,Ribosome biogenesis in eukaryotes,,Major pathway of rRNA processing in the nucleolus and cytosol; Association of TriC/CCT with target proteins during biosynthesis; rRNA modification in the nucleus and cytosol,10,High,1
Q9UMS4,Pre-mRNA-processing factor 19 OS=Homo sapiens OX=9606 GN=PRPF19 PE=1 SV=1,0,85.623,38,8,90,8,504,55.1,6.61,37436,,8,,cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;membrane;nucleus;spliceosomal complex,catalytic activity;metal ion binding;protein binding,"Pf00400, Pf04564, Pf08606, Pf11789",27339,ENSG00000110107.8,PRPF19,11,Ubiquitin mediated proteolysis; Spliceosome,,Dual incision in TC-NER; Formation of TC-NER Pre-Incision Complex; mRNA Splicing - Major Pathway; Gap-filling DNA repair synthesis and ligation in TC-NER,12,High,1
Q9BYD1,"39S ribosomal protein L13, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL13 PE=1 SV=1",0,85.322,59,10,139,10,178,20.7,9.16,57990,0,10,1,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,protein binding;RNA binding;structural molecule activity,Pf00572,28998,ENSG00000172172.7,MRPL13,8,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
Q9H0W9,Ester hydrolase C11orf54 OS=Homo sapiens OX=9606 GN=C11orf54 PE=1 SV=1,0,85.315,25,9,228,9,315,35.1,6.7,113586,6.6,8,2,,nucleus,catalytic activity;metal ion binding;protein binding,Pf08925,28970,ENSG00000182919.14,C11orf54,11,,,,0,High,1
P18031,Tyrosine-protein phosphatase non-receptor type 1 OS=Homo sapiens OX=9606 GN=PTPN1 PE=1 SV=1,0,85.208,32,13,54,13,435,49.9,6.27,25880,,13,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;endosome;membrane,catalytic activity;metal ion binding;protein binding;RNA binding,"Pf00102, Pf00782",5770,ENSG00000196396.9,PTPN1,20,Insulin signaling pathway; Adherens junction; Insulin resistance,Leptin signaling pathway; Prolactin Signaling Pathway; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; Insulin Signaling,Regulation of IFNA signaling; Negative regulation of MET activity; Regulation of IFNG signaling; PTK6 Down-Regulation; Integrin alphaIIb beta3 signaling; Growth hormone receptor signaling,28,High,1
O60568,Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 OS=Homo sapiens OX=9606 GN=PLOD3 PE=1 SV=1,0,85.166,31,16,64,16,738,84.7,6.05,24017,,16,,cell organization and biogenesis;metabolic process;response to stimulus,endoplasmic reticulum;Golgi;membrane,catalytic activity;metal ion binding;protein binding,Pf03171,8985,ENSG00000106397.11,PLOD3,7,Other types of O-glycan biosynthesis; Lysine degradation,,Collagen biosynthesis and modifying enzymes,5,High,1
Q9H3P7,Golgi resident protein GCP60 OS=Homo sapiens OX=9606 GN=ACBD3 PE=1 SV=4,0,85.121,31,11,74,11,528,60.6,5.06,33133,,11,,metabolic process;transport,Golgi;membrane;mitochondrion,protein binding,"Pf00373, Pf00887, Pf13897",64746,ENSG00000182827.8,ACBD3,1,,,Golgi Associated Vesicle Biogenesis,5,High,1
Q9NYK5,"39S ribosomal protein L39, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL39 PE=1 SV=3",0,85.013,33,11,145,11,338,38.7,7.65,68936,,11,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,nucleotide binding;RNA binding,Pf02824,54148,ENSG00000154719.13,MRPL39,21,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
Q5T6V5,Queuosine salvage protein OS=Homo sapiens OX=9606 GN=C9orf64 PE=1 SV=1,0,84.921,43,14,120,14,341,39,5.88,49923,,14,,metabolic process,,,Pf10343,84267,ENSG00000165118.14,C9orf64,9,,,,0,High,1
O15145,Actin-related protein 2/3 complex subunit 3 OS=Homo sapiens OX=9606 GN=ARPC3 PE=1 SV=3,0,84.687,46,7,250,7,178,20.5,8.59,112048,0,7,1,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane,protein binding;structural molecule activity,Pf04062,10094,ENSG00000111229.15,ARPC3,12,Fc gamma R-mediated phagocytosis; Endocytosis; Regulation of actin cytoskeleton; Pathogenic Escherichia coli infection; Shigellosis; Bacterial invasion of epithelial cells; Salmonella infection,Pathogenic Escherichia coli infection,EPHB-mediated forward signaling; Clathrin-mediated endocytosis; RHO GTPases Activate WASPs and WAVEs; Regulation of actin dynamics for phagocytic cup formation,23,High,1
Q14696,LRP chaperone MESD OS=Homo sapiens OX=9606 GN=MESD PE=1 SV=2,0,84.55,47,12,124,11,234,26.1,7.78,49333,0,12,1,metabolic process;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;membrane,protein binding,Pf10185,23184,ENSG00000117899.10,MESDC2; MESD,15,,,,0,High,1
Q9NTJ4,Alpha-mannosidase 2C1 OS=Homo sapiens OX=9606 GN=MAN2C1 PE=1 SV=1,0,84.549,24,15,91,15,1040,115.8,6.57,39243,13.23,13,3,metabolic process,cytoplasm;cytosol;vacuole,catalytic activity;metal ion binding,"Pf01074, Pf07748, Pf09261",4123,ENSG00000140400.16,MAN2C1,15,Other glycan degradation,,Lysosomal oligosaccharide catabolism,4,High,1
Q8N5M1,ATP synthase mitochondrial F1 complex assembly factor 2 OS=Homo sapiens OX=9606 GN=ATPAF2 PE=1 SV=1,0,84.506,48,9,110,9,289,32.8,7.09,52085,,9,,cell organization and biogenesis,cytosol;mitochondrion,protein binding,Pf07542,91647,ENSG00000171953.15,ATPAF2,17,,,,0,High,1
Q9Y450,HBS1-like protein OS=Homo sapiens OX=9606 GN=HBS1L PE=1 SV=1,0,84.42,27,14,65,14,684,75.4,6.61,26784,,14,,metabolic process;regulation of biological process;response to stimulus,cytosol;membrane,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00009, Pf03143, Pf03144, Pf08938",10767,ENSG00000112339.14,HBS1L,6,Legionellosis; mRNA surveillance pathway,,mRNA decay by 3' to 5' exoribonuclease,5,High,1
Q16595,"Frataxin, mitochondrial OS=Homo sapiens OX=9606 GN=FXN PE=1 SV=2",0,84.383,35,6,196,6,210,23.1,8.69,94248,2.84,6,1,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;mitochondrion;organelle lumen,catalytic activity;metal ion binding;protein binding,Pf01491,2395,ENSG00000165060.11,FXN,9,Porphyrin and chlorophyll metabolism,,Mitochondrial protein import; Metabolism of proteins; Mitochondrial iron-sulfur cluster biogenesis,5,High,1
Q9H1E5,Thioredoxin-related transmembrane protein 4 OS=Homo sapiens OX=9606 GN=TMX4 PE=1 SV=1,0,84.341,34,10,197,10,349,38.9,4.37,96773,2.61,9,1,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;membrane,catalytic activity,Pf00085,56255,ENSG00000125827.8,TMX4,20,,,,0,High,1
Q9NP72,Ras-related protein Rab-18 OS=Homo sapiens OX=9606 GN=RAB18 PE=1 SV=1,0,84.316,50,10,177,9,206,23,5.24,82178,4.94,10,2,cell organization and biogenesis;development;regulation of biological process;response to stimulus;transport,cytosol;Golgi;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf04670, Pf08477, Pf09439",22931,ENSG00000099246.16,RAB18,10,,,COPI-independent Golgi-to-ER retrograde traffic; Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation,13,High,1
Q9GZT3,"SRA stem-loop-interacting RNA-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=SLIRP PE=1 SV=1",0,84.295,67,8,347,8,109,12.3,10.24,177149,3.07,7,2,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process,cytoplasm;mitochondrion;nucleus,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",81892,ENSG00000119705.9,SLIRP,14,,,,0,High,1
Q13362,Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform OS=Homo sapiens OX=9606 GN=PPP2R5C PE=1 SV=3,0,84.229,29,12,114,8,524,61,6.87,49352,7.37,12,1,metabolic process;regulation of biological process;response to stimulus,chromosome;cytosol;Golgi;nucleus,enzyme regulator activity;protein binding,Pf01603,5527,ENSG00000078304.19,PPP2R5C,14,Sphingolipid signaling pathway; Adrenergic signaling in cardiomyocytes; mRNA surveillance pathway; PI3K-Akt signaling pathway; Oocyte meiosis; AMPK signaling pathway; Dopaminergic synapse,Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Wnt Signaling Pathway and Pluripotency; Wnt Signaling Pathway; Glycogen Metabolism; DNA Damage Response (only ATM dependent),"Beta-catenin phosphorylation cascade; AXIN missense mutants destabilize the destruction complex; Negative regulation of MAPK pathway; APC truncation mutants have impaired AXIN binding; CTLA4 inhibitory signaling; Platelet sensitization by LDL; Separation of Sister Chromatids; Interleukin-20 family signaling; S37 mutants of beta-catenin aren't phosphorylated; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; S33 mutants of beta-catenin aren't phosphorylated; Regulation of TP53 Degradation; Disassembly of the destruction complex and recruitment of AXIN to the membrane; S45 mutants of beta-catenin aren't phosphorylated; Misspliced GSK3beta mutants stabilize beta-catenin; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Resolution of Sister Chromatid Cohesion; T41 mutants of beta-catenin aren't phosphorylated; RHO GTPases Activate Formins; RAF activation; Truncations of AMER1 destabilize the destruction complex",74,High,1
P08754,Guanine nucleotide-binding protein G(i) subunit alpha OS=Homo sapiens OX=9606 GN=GNAI3 PE=1 SV=3,0,84.083,31,8,256,4,354,40.5,5.69,119068,,8,,cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;Golgi;membrane;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,"Pf00025, Pf00503",2773,ENSG00000065135.10,GNAI3,1,Tight junction; Long-term depression; Pertussis; Regulation of lipolysis in adipocytes; Circadian entrainment; Alcoholism; Renin secretion; Cocaine addiction; Chagas disease (American trypanosomiasis); Melanogenesis; Platelet activation; Gap junction; cAMP signaling pathway; Progesterone-mediated oocyte maturation; Gastric acid secretion; Glutamatergic synapse; Retrograde endocannabinoid signaling; Morphine addiction; Chemokine signaling pathway; Serotonergic synapse; Parkinson's disease; Oxytocin signaling pathway; GABAergic synapse; Dopaminergic synapse; Toxoplasmosis; Cholinergic synapse; Rap1 signaling pathway; Sphingolipid signaling pathway; Adrenergic signaling in cardiomyocytes; Estrogen signaling pathway; cGMP-PKG signaling pathway; Leukocyte transendothelial migration; Pathways in cancer; Axon guidance,Human Thyroid Stimulating Hormone (TSH) signaling pathway; Signal Transduction of S1P Receptor; G Protein Signaling Pathways; Chemokine signaling pathway; Calcium Regulation in the Cardiac Cell,G alpha (z) signalling events; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G alpha (s) signalling events; PLC beta mediated events; ADP signalling through P2Y purinoceptor 12; Adenylate cyclase inhibitory pathway; G-protein activation,65,High,1
P06730,Eukaryotic translation initiation factor 4E OS=Homo sapiens OX=9606 GN=EIF4E PE=1 SV=2,0,84.027,38,9,153,9,217,25.1,6.15,70295,,9,,defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol,protein binding;RNA binding,Pf01652,1977,ENSG00000151247.12,EIF4E,4,PI3K-Akt signaling pathway; HIF-1 signaling pathway; RNA transport; EGFR tyrosine kinase inhibitor resistance; Insulin signaling pathway; Longevity regulating pathway; mTOR signaling pathway,"Translation Factors; Leptin signaling pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Structural Pathway of Interleukin 1 (IL-1); Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Insulin Signaling; Hypertrophy Model; Interferon type I signaling pathways",ISG15 antiviral mechanism; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; mTORC1-mediated signalling; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Transport of the SLBP independent Mature mRNA; GTP hydrolysis and joining of the 60S ribosomal subunit; Deadenylation of mRNA; Ribosomal scanning and start codon recognition,45,High,1
Q13085,Acetyl-CoA carboxylase 1 OS=Homo sapiens OX=9606 GN=ACACA PE=1 SV=2,0,83.994,11,19,78,11,2346,265.4,6.37,32558,0,19,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;mitochondrion,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00289, Pf00364, Pf01039, Pf02222, Pf02655, Pf02785, Pf02786, Pf07478, Pf08326, Pf13535, Pf15632",31,ENSG00000278540.4; ENSG00000275176.4,ACACA,17; CHR_HSCHR17_7_CTG4,Fatty acid biosynthesis; Propanoate metabolism; AMPK signaling pathway; Pyruvate metabolism; Fatty acid metabolism; Glucagon signaling pathway; Insulin signaling pathway; Metabolic pathways,AMP-activated Protein Kinase (AMPK) Signaling; Sterol Regulatory Element-Binding Proteins (SREBP) signalling; Leptin signaling pathway; Corticotropin-releasing hormone signaling pathway; Mesodermal Commitment Pathway; Fatty Acid Biosynthesis; VEGFA-VEGFR2 Signaling Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Leptin and adiponectin,Fatty acyl-CoA biosynthesis; Import of palmitoyl-CoA into the mitochondrial matrix; Activation of gene expression by SREBF (SREBP); Defective HLCS causes multiple carboxylase deficiency; ChREBP activates metabolic gene expression; Biotin transport and metabolism,35,High,1
Q8IYD1,Eukaryotic peptide chain release factor GTP-binding subunit ERF3B OS=Homo sapiens OX=9606 GN=GSPT2 PE=1 SV=2,0,83.935,22,13,156,2,628,68.8,5.43,64779,1.61,13,2,cell organization and biogenesis;metabolic process,cytoplasm;cytosol,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00009, Pf03143, Pf03144, Pf07145",23708,ENSG00000189369.8,GSPT2,X,mRNA surveillance pathway,Translation Factors,Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC),13,High,1
Q9NTI5,Sister chromatid cohesion protein PDS5 homolog B OS=Homo sapiens OX=9606 GN=PDS5B PE=1 SV=1,0,83.851,15,18,57,16,1447,164.6,8.47,25012,,18,,cell division;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus,chromosome;cytosol;nucleus,DNA binding;nucleotide binding;protein binding,,23047,ENSG00000083642.18,PDS5B,13,,,Cohesin Loading onto Chromatin; Establishment of Sister Chromatid Cohesion; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion,12,High,1
Q13126,S-methyl-5'-thioadenosine phosphorylase OS=Homo sapiens OX=9606 GN=MTAP PE=1 SV=2,0,83.803,50,12,146,12,283,31.2,7.18,65690,,12,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,Pf01048,4507,ENSG00000099810.18,MTAP,9,Metabolic pathways; Cysteine and methionine metabolism,,Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Methionine salvage pathway; Interleukin-12 family signaling,12,High,1
P46778,60S ribosomal protein L21 OS=Homo sapiens OX=9606 GN=RPL21 PE=1 SV=2,0,83.651,41,8,189,8,160,18.6,10.49,103365,3.91,8,2,cell organization and biogenesis;metabolic process;transport,cytosol;membrane;ribosome,protein binding;RNA binding;structural molecule activity,Pf01157,6144,ENSG00000122026.10,RPL21,13,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
Q9Y2D4,Exocyst complex component 6B OS=Homo sapiens OX=9606 GN=EXOC6B PE=1 SV=3,0,83.574,24,15,133,13,811,94.1,6.46,57062,0,15,1,transport,,protein binding,Pf04091,23233,ENSG00000144036.15,EXOC6B,2,,,,0,High,1
P98155,Very low-density lipoprotein receptor OS=Homo sapiens OX=9606 GN=VLDLR PE=1 SV=1,0,83.543,17,13,109,13,873,96,4.79,42814,0,13,1,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,membrane,metal ion binding;protein binding;receptor activity;signal transducer activity;transporter activity,"Pf00057, Pf00058, Pf01456, Pf07645, Pf14670",7436,ENSG00000147852.15,VLDLR,9,,,VLDL clearance; Reelin signalling pathway; VLDLR internalisation and degradation,8,High,1
A5YKK6,CCR4-NOT transcription complex subunit 1 OS=Homo sapiens OX=9606 GN=CNOT1 PE=1 SV=2,0,83.522,11,18,65,18,2376,266.8,7.11,24808,,18,,development;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,catalytic activity;protein binding;RNA binding;structural molecule activity,"Pf04054, Pf12842",23019,ENSG00000125107.17,CNOT1,16,RNA degradation,,TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Deadenylation of mRNA,10,High,1
Q9BV57,"1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase OS=Homo sapiens OX=9606 GN=ADI1 PE=1 SV=1",0,83.481,63,10,149,10,179,21.5,5.68,72802,,10,,metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;nucleus,catalytic activity;metal ion binding;protein binding,"Pf02311, Pf03079, Pf07883",55256,ENSG00000182551.13,ADI1,2,Metabolic pathways; Cysteine and methionine metabolism,,Methionine salvage pathway,7,High,1
Q9UGM6,"Tryptophan--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=WARS2 PE=1 SV=1",0,83.369,38,8,114,8,360,40.1,9.28,50630,,8,,cell differentiation;metabolic process,cytoplasm;membrane;mitochondrion;organelle lumen,catalytic activity;nucleotide binding,Pf00579,10352,ENSG00000116874.11,WARS2,1,Aminoacyl-tRNA biosynthesis,,Mitochondrial tRNA aminoacylation,5,High,1
O14964,Hepatocyte growth factor-regulated tyrosine kinase substrate OS=Homo sapiens OX=9606 GN=HGS PE=1 SV=1,0,83.367,22,14,100,13,777,86.1,6.16,45459,0,14,1,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane;vacuole,catalytic activity;metal ion binding;protein binding,"Pf00790, Pf01363, Pf09770, Pf12210, Pf13388",9146,ENSG00000185359.12,HGS,17,Phagosome; Endocytosis,TGF-beta Signaling Pathway; VEGFA-VEGFR2 Signaling Pathway; EGF/EGFR Signaling Pathway,Cargo recognition for clathrin-mediated endocytosis; Negative regulation of MET activity; Ub-specific processing proteases; EGFR downregulation; InlB-mediated entry of Listeria monocytogenes into host cell; Lysosome Vesicle Biogenesis; Endosomal Sorting Complex Required For Transport (ESCRT),27,High,1
P61011,Signal recognition particle 54 kDa protein OS=Homo sapiens OX=9606 GN=SRP54 PE=1 SV=1,0,83.24,29,11,57,11,504,55.7,8.75,25968,3.19,11,1,cell organization and biogenesis;metabolic process;response to stimulus;transport,cytoplasm;cytosol;nucleus,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00448, Pf01656, Pf02881, Pf02978, Pf03205, Pf09974, Pf13207, Pf13671",6729,ENSG00000100883.11,SRP54,14,Protein export,mRNA Processing,SRP-dependent cotranslational protein targeting to membrane,5,High,1
P52788,Spermine synthase OS=Homo sapiens OX=9606 GN=SMS PE=1 SV=2,0,83.176,38,10,131,10,366,41.2,5.02,57067,,10,,metabolic process,cytosol,catalytic activity,Pf01564,6611,ENSG00000102172.15,SMS,X,Glutathione metabolism; Metabolic pathways; Cysteine and methionine metabolism; beta-Alanine metabolism; Arginine and proline metabolism,Amino Acid metabolism; Urea cycle and metabolism of amino groups,Metabolism of polyamines,10,High,1
Q9Y6B6,GTP-binding protein SAR1b OS=Homo sapiens OX=9606 GN=SAR1B PE=1 SV=1,0,83.159,64,8,274,5,198,22.4,6.11,130844,2.7,7,3,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytosol;endoplasmic reticulum;Golgi;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,"Pf00025, Pf00503, Pf01926, Pf08477, Pf09439",51128,ENSG00000152700.13,SAR1B,5,Protein processing in endoplasmic reticulum; Legionellosis,Sterol Regulatory Element-Binding Proteins (SREBP) signalling,"Regulation of cholesterol biosynthesis by SREBP (SREBF); Cargo concentration in the ER; Chylomicron assembly; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; COPII (Coat Protein 2) Mediated Vesicle Transport; MHC class II antigen presentation",25,High,1
Q12959-2,Isoform 2 of Disks large homolog 1 OS=Homo sapiens OX=9606 GN=DLG1,0,83.157,23,17,91,15,926,103.3,5.92,34649,4.27,16,1,cell communication;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;Golgi;membrane;nucleus,catalytic activity;protein binding;structural molecule activity;transporter activity,"Pf00018, Pf00595, Pf00625, Pf07653, Pf09058, Pf10600, Pf10608, Pf13180",1739,ENSG00000075711.20,DLG1,3,,Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection,,2,High,1
Q9UBB4,Ataxin-10 OS=Homo sapiens OX=9606 GN=ATXN10 PE=1 SV=1,0,83.129,32,13,128,13,475,53.5,5.25,60487,,13,,cell organization and biogenesis,cytoplasm;cytosol;membrane,protein binding,Pf09759,25814,ENSG00000130638.16,ATXN10,22,,,,0,High,1
P22748,Carbonic anhydrase 4 OS=Homo sapiens OX=9606 GN=CA4 PE=1 SV=2,0,83.079,32,9,216,9,312,35,7.83,95771,0,9,1,metabolic process;transport,cell surface;endoplasmic reticulum;Golgi;membrane,catalytic activity;metal ion binding;protein binding,Pf00194,762,ENSG00000167434.9,CA4,17,Nitrogen metabolism; Proximal tubule bicarbonate reclamation,,Reversible hydration of carbon dioxide; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide,8,High,1
O60645,Exocyst complex component 3 OS=Homo sapiens OX=9606 GN=EXOC3 PE=1 SV=3,0,83.043,29,16,108,16,745,85.5,6.29,40211,6.9,16,3,,,,,,,,,,,,0,High,1
P18621,60S ribosomal protein L17 OS=Homo sapiens OX=9606 GN=RPL17 PE=1 SV=3,0,82.925,41,8,262,8,184,21.4,10.17,118206,6.41,7,3,cell organization and biogenesis;metabolic process;transport,cytosol;nucleus;ribosome,protein binding;RNA binding;structural molecule activity,Pf00237,6139,ENSG00000215472.10; ENSG00000265681.7,RPL17,18,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
Q6P1X6,UPF0598 protein C8orf82 OS=Homo sapiens OX=9606 GN=C8orf82 PE=1 SV=2,0,82.747,41,9,84,9,216,23.9,9.14,36072,16.44,7,3,,,,Pf14956,414919,ENSG00000213563.6,C8orf82,8,,,,0,High,1
P52948,Nuclear pore complex protein Nup98-Nup96 OS=Homo sapiens OX=9606 GN=NUP98 PE=1 SV=4,0,82.677,12,16,56,16,1817,197.5,6.4,23477,,16,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,chromosome;cytosol;membrane;nucleus,catalytic activity;protein binding;RNA binding;structural molecule activity;transporter activity,"Pf04096, Pf12110, Pf13634",4928,ENSG00000110713.15,NUP98,11,RNA transport; Influenza A,,,2,High,1
Q8WZA9,Immunity-related GTPase family Q protein OS=Homo sapiens OX=9606 GN=IRGQ PE=1 SV=1,0,82.666,31,14,105,14,623,62.7,4.88,42263,0,14,1,,,nucleotide binding,,126298,ENSG00000167378.8,IRGQ,19,,,,0,High,1
Q9NX14,"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFB11 PE=1 SV=1",0,82.629,46,7,354,7,153,17.3,5.22,175494,10.78,6,2,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion,protein binding,Pf10183,54539,ENSG00000147123.10,NDUFB11,X,Non-alcoholic fatty liver disease (NAFLD); Huntington's disease; Alzheimer's disease; Metabolic pathways; Oxidative phosphorylation; Parkinson's disease,,Complex I biogenesis,11,High,1
P60900,Proteasome subunit alpha type-6 OS=Homo sapiens OX=9606 GN=PSMA6 PE=1 SV=1,0,82.564,45,11,291,11,246,27.4,6.76,147581,0,10,2,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus;proteasome,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00227, Pf10584",5687,ENSG00000100902.10,PSMA6,14,Proteasome,Proteasome Degradation,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,150,High,1
O94929,Actin-binding LIM protein 3 OS=Homo sapiens OX=9606 GN=ABLIM3 PE=1 SV=3,0,82.547,25,13,77,12,683,77.8,8.54,34303,6.33,12,3,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm,metal ion binding;protein binding,"Pf00412, Pf02209",22885,ENSG00000173210.19,ABLIM3,5,Axon guidance,,DCC mediated attractive signaling,5,High,1
Q93062,RNA-binding protein with multiple splicing OS=Homo sapiens OX=9606 GN=RBPMS PE=1 SV=1,0,82.508,54,10,143,7,196,21.8,8.07,70443,,10,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",11030,ENSG00000157110.15,RBPMS,8,,Exercise-induced Circadian Regulation,,1,High,1
Q86YM7,Homer protein homolog 1 OS=Homo sapiens OX=9606 GN=HOMER1 PE=1 SV=2,0,82.467,43,14,115,11,354,40.3,5.44,47639,,14,,cell communication;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,protein binding,"Pf00568, Pf04111, Pf04156",9456,ENSG00000152413.14,HOMER1,5,FoxO signaling pathway; Glutamatergic synapse,BDNF-TrkB Signaling,Neurexins and neuroligins,6,High,1
Q92995,Ubiquitin carboxyl-terminal hydrolase 13 OS=Homo sapiens OX=9606 GN=USP13 PE=1 SV=2,0,82.454,27,17,141,15,863,97.3,5.53,58741,0,17,1,cell differentiation;cell proliferation;metabolic process;regulation of biological process,cytosol,catalytic activity;metal ion binding;protein binding,"Pf00443, Pf00627, Pf02148, Pf13423",8975,ENSG00000058056.8,USP13,3,,,Regulation of PTEN stability and activity; Ub-specific processing proteases,9,High,1
O60237-3,Isoform 3 of Protein phosphatase 1 regulatory subunit 12B OS=Homo sapiens OX=9606 GN=PPP1R12B,0,82.389,49,9,271,1,224,26.2,5.92,129059,58.38,7,5,regulation of biological process;response to stimulus,cytosol,enzyme regulator activity;protein binding,,4660,ENSG00000077157.21,PPP1R12B,1,,,,0,High,1
P36873,Serine/threonine-protein phosphatase PP1-gamma catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CC PE=1 SV=1,0,82.289,30,11,183,3,323,37,6.54,91274,4.82,10,2,cell differentiation;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;cytosol;membrane;mitochondrion;nucleus,catalytic activity;metal ion binding;protein binding;RNA binding,Pf00149,5501,ENSG00000186298.11,PPP1CC,12,Adrenergic signaling in cardiomyocytes; Platelet activation; Hippo signaling pathway; Alcoholism; Insulin signaling pathway; Oocyte meiosis; Proteoglycans in cancer; Long-term potentiation; Insulin resistance; cGMP-PKG signaling pathway; Inflammatory mediator regulation of TRP channels; Vascular smooth muscle contraction; mRNA surveillance pathway; Focal adhesion; Oxytocin signaling pathway; Amphetamine addiction; Dopaminergic synapse; cAMP signaling pathway; Herpes simplex infection; Regulation of actin cytoskeleton,Common Pathways Underlying Drug Addiction,Triglyceride catabolism; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Separation of Sister Chromatids; Downregulation of TGF-beta receptor signaling; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; Circadian Clock,46,High,1
O75569,Interferon-inducible double-stranded RNA-dependent protein kinase activator A OS=Homo sapiens OX=9606 GN=PRKRA PE=1 SV=1,0,82.259,34,8,121,8,313,34.4,8.41,58585,0,8,3,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,enzyme regulator activity;protein binding;RNA binding,"Pf00035, Pf14709",8575,ENSG00000180228.12,PRKRA,2,,,MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis,4,High,1
Q9NTG7,"NAD-dependent protein deacetylase sirtuin-3, mitochondrial OS=Homo sapiens OX=9606 GN=SIRT3 PE=1 SV=2",0,82.235,28,11,220,11,399,43.5,8.7,112272,,11,,cell organization and biogenesis;metabolic process;regulation of biological process,mitochondrion;organelle lumen,catalytic activity;metal ion binding;nucleotide binding;protein binding,Pf02146,23410,ENSG00000142082.14,SIRT3,11,Central carbon metabolism in cancer,"Energy Metabolism; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways",Transcriptional activation of mitochondrial biogenesis,8,High,1
Q9NR46,Endophilin-B2 OS=Homo sapiens OX=9606 GN=SH3GLB2 PE=1 SV=1,0,82.225,33,10,81,9,395,43.9,5.99,41292,,10,,,cytoplasm;cytosol,protein binding,"Pf03114, Pf14604",56904,ENSG00000148341.17,SH3GLB2,9,Endocytosis,,,1,High,1
Q9P291,Armadillo repeat-containing X-linked protein 1 OS=Homo sapiens OX=9606 GN=ARMCX1 PE=1 SV=1,0,82.141,32,11,124,11,453,49.2,9.22,54381,12.27,9,2,,membrane;mitochondrion,protein binding,"Pf04826, Pf09759, Pf13646",51309,ENSG00000126947.12,ARMCX1,X,,,,0,High,1
Q8IUD2,ELKS/Rab6-interacting/CAST family member 1 OS=Homo sapiens OX=9606 GN=ERC1 PE=1 SV=1,0,82.131,20,17,54,17,1116,128,5.97,23371,,17,,development;metabolic process;regulation of biological process;transport,cytoplasm;endoplasmic reticulum;Golgi;membrane,protein binding;transporter activity,"Pf01496, Pf04156, Pf05529, Pf05557, Pf05622, Pf07888, Pf09457, Pf09726, Pf10174, Pf10186, Pf12128, Pf13166",23085,ENSG00000283017.1; ENSG00000082805.19,ERC1,12; CHR_HSCHR12_2_CTG1,NF-kappa B signaling pathway,,,1,High,1
Q711Q0,Cardiac-enriched FHL2-interacting protein OS=Homo sapiens OX=9606 GN=CEFIP PE=1 SV=2,0,82.105,16,14,52,14,1435,156.4,6.38,,88.49,,14,,,,Pf15232,118461,ENSG00000177354.11,C10orf71,10,,,,0,High,1
Q9Y2W1,Thyroid hormone receptor-associated protein 3 OS=Homo sapiens OX=9606 GN=THRAP3 PE=1 SV=2,0,82.103,15,12,80,11,955,108.6,10.15,34019,2.29,12,1,metabolic process;regulation of biological process;response to stimulus,nucleus,DNA binding;nucleotide binding;protein binding;receptor activity;RNA binding,Pf15440,9967,ENSG00000054118.13,THRAP3,1,,Interactome of polycomb repressive complex 2 (PRC2),Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression,7,High,1
Q9Y5U8,Mitochondrial pyruvate carrier 1 OS=Homo sapiens OX=9606 GN=MPC1 PE=1 SV=1,0,82.101,50,9,116,9,109,12.3,9.61,51497,6.11,8,1,metabolic process;transport,membrane;mitochondrion,catalytic activity;transporter activity,"Pf01483, Pf03650",51660,ENSG00000060762.18,MPC1,6,,Glycolysis and Gluconeogenesis,Pyruvate metabolism,5,High,1
P41226,Ubiquitin-like modifier-activating enzyme 7 OS=Homo sapiens OX=9606 GN=UBA7 PE=1 SV=2,0,82.022,21,12,58,12,1012,111.6,6.04,21837,,12,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,catalytic activity;nucleotide binding;protein binding,"Pf00899, Pf02134, Pf05237, Pf09358, Pf10585",7318,ENSG00000182179.12,UBA7,3,Ubiquitin mediated proteolysis; Parkinson's disease,Proteasome Degradation; Parkinsons Disease Pathway,Termination of translesion DNA synthesis; ISG15 antiviral mechanism; Negative regulators of DDX58/IFIH1 signaling; Antigen processing: Ubiquitination & Proteasome degradation,19,High,1
P02743,Serum amyloid P-component OS=Homo sapiens OX=9606 GN=APCS PE=1 SV=2,0,81.84,41,13,538,13,223,25.4,6.54,282846,1.83,13,3,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;nucleus,metal ion binding;protein binding,"Pf00354, Pf13385",325,ENSG00000132703.3,APCS,1,,,Amyloid fiber formation,2,High,1
Q99829,Copine-1 OS=Homo sapiens OX=9606 GN=CPNE1 PE=1 SV=1,0,81.797,23,12,89,12,537,59,5.83,40549,,12,,cell differentiation;cell growth;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus,catalytic activity;metal ion binding;protein binding;transporter activity,"Pf00092, Pf00168, Pf07002, Pf10138, Pf13519",8904,ENSG00000214078.12,CPNE1,20,,,Neutrophil degranulation; Glycerophospholipid biosynthesis,7,High,1
Q9NR31,GTP-binding protein SAR1a OS=Homo sapiens OX=9606 GN=SAR1A PE=1 SV=1,0,81.693,65,9,231,6,198,22.4,6.68,125091,11.47,8,3,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;Golgi;membrane,catalytic activity;nucleotide binding;protein binding;signal transducer activity,"Pf00025, Pf00071, Pf00503, Pf01926, Pf08477, Pf09439",56681,ENSG00000079332.14,SAR1A,10,Legionellosis; Protein processing in endoplasmic reticulum,Sterol Regulatory Element-Binding Proteins (SREBP) signalling,,3,High,1
Q8N4Q0,Prostaglandin reductase 3 OS=Homo sapiens OX=9606 GN=ZADH2 PE=1 SV=1,0,81.679,32,9,194,9,377,40.1,8.18,85317,0,9,1,metabolic process;regulation of biological process,mitochondrion,catalytic activity;metal ion binding,"Pf00107, Pf08240",284273,ENSG00000180011.6,ZADH2,18,,,,0,High,1
O75822,Eukaryotic translation initiation factor 3 subunit J OS=Homo sapiens OX=9606 GN=EIF3J PE=1 SV=2,0,81.591,55,12,88,12,258,29,4.83,43476,,12,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol,protein binding;RNA binding,Pf08597,8669,ENSG00000104131.12,EIF3J,15,RNA transport,Translation Factors,"Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Ribosomal scanning and start codon recognition",13,High,1
Q9BR76,Coronin-1B OS=Homo sapiens OX=9606 GN=CORO1B PE=1 SV=1,0,81.481,23,11,106,10,489,54.2,5.88,47751,0,11,1,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane,protein binding,"Pf00400, Pf08953, Pf08954",57175,ENSG00000172725.13,CORO1B,11,,,,0,High,1
Q8IX01,SURP and G-patch domain-containing protein 2 OS=Homo sapiens OX=9606 GN=SUGP2 PE=1 SV=2,0,81.441,17,17,61,17,1082,120.1,7.28,26219,2.14,17,1,metabolic process,nucleus,RNA binding,"Pf01585, Pf01805, Pf12656",10147,ENSG00000064607.16,SUGP2,19,,mRNA Processing,,1,High,1
Q9H9J2,"39S ribosomal protein L44, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL44 PE=1 SV=1",0,81.361,34,11,95,11,332,37.5,8.4,43502,0,10,1,cell organization and biogenesis;metabolic process,membrane;mitochondrion;nucleus;ribosome,catalytic activity;protein binding;RNA binding,Pf00636,65080,ENSG00000135900.3,MRPL44,2,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
Q9NQZ5,"StAR-related lipid transfer protein 7, mitochondrial OS=Homo sapiens OX=9606 GN=STARD7 PE=1 SV=2",0,81.326,41,11,69,11,370,43.1,8.95,25417,23.59,11,4,metabolic process,membrane;mitochondrion,,Pf01852,56910,ENSG00000084090.13,STARD7,2,,,Synthesis of PC,5,High,1
O43865,S-adenosylhomocysteine hydrolase-like protein 1 OS=Homo sapiens OX=9606 GN=AHCYL1 PE=1 SV=2,0,81.259,27,12,94,7,530,58.9,6.89,40273,,12,,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;membrane,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00670, Pf01262, Pf01488, Pf02254, Pf02826, Pf05221",10768,ENSG00000168710.17,AHCYL1,1,Cysteine and methionine metabolism; Metabolic pathways,Trans-sulfuration and one carbon metabolism; One carbon metabolism and related pathways,Ion homeostasis; FCERI mediated Ca+2 mobilization; PLC beta mediated events; DAG and IP3 signaling; Signaling by GPCR; Regulation of insulin secretion; VEGFR2 mediated cell proliferation; CLEC7A (Dectin-1) induces NFAT activation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of phospholipids in phagocytosis,33,High,1
P49903,"Selenide, water dikinase 1 OS=Homo sapiens OX=9606 GN=SEPHS1 PE=1 SV=2",0,81.24,46,11,91,11,392,42.9,5.97,36884,0,11,1,metabolic process,cytoplasm;membrane;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00586, Pf02769",22929,ENSG00000086475.14,SEPHS1,10,Selenocompound metabolism; Metabolic pathways,,,2,High,1
Q9BYD6,"39S ribosomal protein L1, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL1 PE=1 SV=2",0,81.114,33,9,153,9,325,36.9,8.78,73019,0,9,1,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,protein binding;RNA binding;structural molecule activity,"Pf00687, Pf13003",65008,ENSG00000169288.17,MRPL1,4,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
Q9H4B7,Tubulin beta-1 chain OS=Homo sapiens OX=9606 GN=TUBB1 PE=1 SV=1,0,81.01,8,8,1398,1,451,50.3,5.17,713634,3.67,8,3,cell organization and biogenesis,cytoplasm;cytoskeleton,catalytic activity;nucleotide binding;structural molecule activity,"Pf00091, Pf03953",81027,ENSG00000101162.3,TUBB1,20,Pathogenic Escherichia coli infection; Phagosome; Gap junction,Pathogenic Escherichia coli infection; Parkin-Ubiquitin Proteasomal System pathway,COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Translocation of GLUT4 to the plasma membrane; Prefoldin mediated transfer of substrate  to CCT/TriC; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Separation of Sister Chromatids; COPI-mediated anterograde transport; HSP90 chaperone cycle for steroid hormone receptors (SHR); The role of GTSE1 in G2/M progression after G2 checkpoint; Kinesins; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; RHO GTPases Activate Formins; Post-chaperonin tubulin folding pathway; MHC class II antigen presentation,65,High,1
Q99715,Collagen alpha-1(XII) chain OS=Homo sapiens OX=9606 GN=COL12A1 PE=1 SV=2,0,80.952,8,17,70,17,3063,332.9,5.53,27753,,17,,cell differentiation;cell organization and biogenesis;metabolic process,extracellular;organelle lumen,protein binding;structural molecule activity,"Pf00041, Pf00092, Pf13519",1303,ENSG00000111799.20,COL12A1,6,Protein digestion and absorption,,Collagen degradation; Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization,8,High,1
Q6NY19,KN motif and ankyrin repeat domain-containing protein 3 OS=Homo sapiens OX=9606 GN=KANK3 PE=1 SV=1,0,80.91,20,12,75,11,840,88.4,5.26,35556,11.41,10,3,,,protein binding,"Pf00023, Pf12075, Pf12796, Pf13606, Pf13637, Pf13857, Pf13900",256949,ENSG00000186994.11,KANK3,19,,,,0,High,1
O43264,Centromere/kinetochore protein zw10 homolog OS=Homo sapiens OX=9606 GN=ZW10 PE=1 SV=3,0,80.907,25,15,82,15,779,88.8,6.27,37386,1.67,14,2,cell division;cell organization and biogenesis;regulation of biological process;transport,chromosome;cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;nucleus,DNA binding;protein binding,Pf06248,9183,ENSG00000086827.8,ZW10,11,,,COPI-dependent Golgi-to-ER retrograde traffic; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins,21,High,1
Q13084,"39S ribosomal protein L28, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL28 PE=1 SV=4",0,80.787,46,10,164,10,256,30.1,8.29,73588,0,10,1,cell organization and biogenesis;metabolic process,cytosol;membrane;mitochondrion;ribosome,protein binding;RNA binding;structural molecule activity,Pf00830,10573,ENSG00000086504.15,MRPL28,16,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
Q8NC51,Plasminogen activator inhibitor 1 RNA-binding protein OS=Homo sapiens OX=9606 GN=SERBP1 PE=1 SV=2,0,80.764,40,12,96,11,408,44.9,8.65,37302,9.19,11,1,regulation of biological process,cytoplasm;cytosol;membrane;nucleus,protein binding;RNA binding,Pf04774,26135,ENSG00000142864.14,SERBP1,1,,Apoptosis-related network due to altered Notch3 in ovarian cancer,,1,High,1
Q9NS69,Mitochondrial import receptor subunit TOM22 homolog OS=Homo sapiens OX=9606 GN=TOMM22 PE=1 SV=3,0,80.763,77,7,153,7,142,15.5,4.34,79715,,7,,cell communication;cell organization and biogenesis;metabolic process;response to stimulus;transport,membrane;mitochondrion,protein binding;transporter activity,,56993,ENSG00000100216.5,TOMM22,22,,,Mitochondrial protein import; Metabolism of proteins; Pink/Parkin Mediated Mitophagy,4,High,1
Q8NE79,Blood vessel epicardial substance OS=Homo sapiens OX=9606 GN=BVES PE=1 SV=1,0,80.717,23,6,224,6,360,41.4,7.9,79361,113.2,5,2,cell organization and biogenesis;development;regulation of biological process;response to stimulus;transport,membrane,nucleotide binding;protein binding;structural molecule activity,"Pf00027, Pf04831",11149,ENSG00000112276.13,BVES,6,,,,0,High,1
P51572,B-cell receptor-associated protein 31 OS=Homo sapiens OX=9606 GN=BCAP31 PE=1 SV=3,0,80.636,22,7,165,7,246,28,8.44,76313,,7,,cell death;cellular homeostasis;regulation of biological process;response to stimulus;transport,cytosol;endoplasmic reticulum;membrane;mitochondrion,protein binding,"Pf05529, Pf13870",10134,ENSG00000185825.15,BCAP31,X,Protein processing in endoplasmic reticulum,,"Apoptotic cleavage of cellular proteins; Antigen Presentation: Folding, assembly and peptide loading of class I MHC",9,High,1
Q8WXI4,Acyl-coenzyme A thioesterase 11 OS=Homo sapiens OX=9606 GN=ACOT11 PE=1 SV=1,0,80.588,31,13,186,13,607,68.4,8.35,75976,52.02,8,5,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,catalytic activity,"Pf01852, Pf03061, Pf12729",26027,ENSG00000162390.17,ACOT11,1,,,Mitochondrial Fatty Acid Beta-Oxidation,4,High,1
Q8TBC4,NEDD8-activating enzyme E1 catalytic subunit OS=Homo sapiens OX=9606 GN=UBA3 PE=1 SV=2,0,80.514,28,10,151,10,463,51.8,5.45,62977,1.71,10,1,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00899, Pf01488, Pf02134, Pf05237, Pf08825, Pf10585",9039,ENSG00000144744.16,UBA3,3,Ubiquitin mediated proteolysis,,NIK-->noncanonical NF-kB signaling; Dectin-1 mediated noncanonical NF-kB signaling; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation,15,High,1
P08708,40S ribosomal protein S17 OS=Homo sapiens OX=9606 GN=RPS17 PE=1 SV=2,0,80.417,41,6,169,6,135,15.5,9.85,88149,,6,,cell organization and biogenesis;metabolic process;transport,cytosol;membrane;ribosome,RNA binding;structural molecule activity,Pf00833,6218,ENSG00000278229.2; ENSG00000182774.10,RPS17; RPS17L,15; CHR_HSCHR15_5_CTG8,Ribosome,Cytoplasmic Ribosomal Proteins,"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane",38,High,1
O15498,Synaptobrevin homolog YKT6 OS=Homo sapiens OX=9606 GN=YKT6 PE=1 SV=1,0,80.362,62,10,108,10,198,22.4,6.92,44862,0,10,1,cell organization and biogenesis;transport,cytoplasm;cytosol;endoplasmic reticulum;endosome;Golgi;membrane;mitochondrion,catalytic activity;protein binding,"Pf00957, Pf13774",10652,ENSG00000106636.7,YKT6,7,SNARE interactions in vesicular transport,,COPI-mediated anterograde transport; Intra-Golgi traffic; COPII (Coat Protein 2) Mediated Vesicle Transport,12,High,1
Q14847,LIM and SH3 domain protein 1 OS=Homo sapiens OX=9606 GN=LASP1 PE=1 SV=2,0,80.323,49,12,137,12,261,29.7,7.05,58794,17.15,11,1,regulation of biological process;transport,cytoplasm;cytoskeleton,metal ion binding;protein binding;transporter activity,"Pf00018, Pf00412, Pf00880, Pf07653, Pf14604",3927,ENSG00000002834.17,LASP1,17,,,,0,High,1
Q92625,Ankyrin repeat and SAM domain-containing protein 1A OS=Homo sapiens OX=9606 GN=ANKS1A PE=1 SV=4,0,80.314,19,14,63,14,1134,123,6.38,27996,,14,,cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytosol,protein binding,"Pf00023, Pf00536, Pf00640, Pf07647, Pf12796, Pf13606, Pf13637, Pf13857",23294,ENSG00000064999.13,ANKS1A,6,,,,0,High,1
Q9HB71,Calcyclin-binding protein OS=Homo sapiens OX=9606 GN=CACYBP PE=1 SV=2,0,80.278,49,7,82,7,228,26.2,8.25,41657,,7,,cell differentiation;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,protein binding,"Pf04969, Pf05002, Pf09032",27101,ENSG00000116161.17,CACYBP,1,Wnt signaling pathway,Gastric cancer network 2,,2,High,1
Q6P2E9,Enhancer of mRNA-decapping protein 4 OS=Homo sapiens OX=9606 GN=EDC4 PE=1 SV=1,0,80.198,15,13,70,13,1401,151.6,5.86,31756,,13,,metabolic process,cytoplasm;cytosol;membrane;nucleus,protein binding,Pf00400,23644,ENSG00000038358.14,EDC4,16,RNA degradation,,mRNA decay by 5' to 3' exoribonuclease,4,High,1
P61970,Nuclear transport factor 2 OS=Homo sapiens OX=9606 GN=NUTF2 PE=1 SV=1,0,80.173,57,8,246,8,127,14.5,5.38,119533,23.11,7,2,cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytosol;membrane;nucleus,protein binding;transporter activity,Pf02136,10204,ENSG00000102898.11,NUTF2,16,,,,0,High,1
P30626,Sorcin OS=Homo sapiens OX=9606 GN=SRI PE=1 SV=1,0,80.147,47,11,235,11,198,21.7,5.59,109642,0,11,2,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;membrane;mitochondrion,catalytic activity;metal ion binding;protein binding,"Pf13405, Pf13499, Pf13833",6717,ENSG00000075142.13,SRI,7,,,Ion homeostasis; Sodium/Calcium exchangers; Ion transport by P-type ATPases; Reduction of cytosolic Ca++ levels; Stimuli-sensing channels,14,High,1
Q96BW5,Phosphotriesterase-related protein OS=Homo sapiens OX=9606 GN=PTER PE=1 SV=1,0,80.119,29,10,143,10,349,39,6.52,61152,0,10,1,cell differentiation;metabolic process,,catalytic activity;metal ion binding,"Pf01026, Pf02126",9317,ENSG00000165983.14,PTER,10,,,,0,High,1
Q9NX46,ADP-ribose glycohydrolase ARH3 OS=Homo sapiens OX=9606 GN=ADPRHL2 PE=1 SV=1,0,80.092,47,11,114,11,363,38.9,5.07,50996,,11,,response to stimulus,cytoplasm;mitochondrion;nucleus;organelle lumen,catalytic activity;metal ion binding,Pf03747,54936,ENSG00000116863.10,ADPRHL2,1,,,POLB-Dependent Long Patch Base Excision Repair,5,High,1
P31749,RAC-alpha serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=AKT1 PE=1 SV=2,0,80.079,36,14,116,12,480,55.7,6.07,54111,,14,,cell death;cell differentiation;cell organization and biogenesis;cell proliferation;defense response;development;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding,"Pf00069, Pf00169, Pf00433, Pf07714, Pf14531, Pf15413",207,ENSG00000142208.15,AKT1,14,Dopaminergic synapse; Pancreatic cancer; Rap1 signaling pathway; Thyroid hormone signaling pathway; Apoptosis; Small cell lung cancer; Influenza A; Insulin signaling pathway; B cell receptor signaling pathway; ErbB signaling pathway; EGFR tyrosine kinase inhibitor resistance; Non-alcoholic fatty liver disease (NAFLD); Chemokine signaling pathway; Platelet activation; Osteoclast differentiation; Chronic myeloid leukemia; Endometrial cancer; Tuberculosis; AMPK signaling pathway; Ras signaling pathway; Adipocytokine signaling pathway; Longevity regulating pathway - multiple species; Prolactin signaling pathway; Non-small cell lung cancer; Adrenergic signaling in cardiomyocytes; Jak-STAT signaling pathway; Toll-like receptor signaling pathway; Regulation of lipolysis in adipocytes; Central carbon metabolism in cancer; VEGF signaling pathway; Prostate cancer; Toxoplasmosis; Sphingolipid signaling pathway; cAMP signaling pathway; Hepatitis B; Epstein-Barr virus infection; Colorectal cancer; Melanoma; mTOR signaling pathway; Endocrine resistance; PI3K-Akt signaling pathway; TNF signaling pathway; Phospholipase D signaling pathway; MAPK signaling pathway; Renal cell carcinoma; Proteoglycans in cancer; Hepatitis C; Cholinergic synapse; Chagas disease (American trypanosomiasis); Glioma; Estrogen signaling pathway; Pathways in cancer; Signaling pathways regulating pluripotency of stem cells; Breast cancer; Fc gamma R-mediated phagocytosis; Progesterone-mediated oocyte maturation; Fc epsilon RI signaling pathway; Acute myeloid leukemia; Measles; Neurotrophin signaling pathway; Carbohydrate digestion and absorption; cGMP-PKG signaling pathway; Choline metabolism in cancer; FoxO signaling pathway; Focal adhesion; HIF-1 signaling pathway; HTLV-I infection; Platinum drug resistance; Tight junction; Glucagon signaling pathway; Longevity regulating pathway; T cell receptor signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Insulin resistance,"IL-5 Signaling Pathway; Androgen receptor signaling pathway; AMP-activated Protein Kinase (AMPK) Signaling; Regulation of toll-like receptor signaling pathway; Target Of Rapamycin (TOR) Signaling; Angiogenesis; MicroRNAs in cardiomyocyte hypertrophy; TFs Regulate miRNAs related to cardiac hypertrophy; Integrin-mediated Cell Adhesion; IL-1 signaling pathway; Sterol Regulatory Element-Binding Proteins (SREBP) signalling; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; Human Thyroid Stimulating Hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle Stimulating Hormone (FSH) signaling pathway; TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway; Prolactin Signaling Pathway; Regulation of Microtubule Cytoskeleton; IL-7 Signaling Pathway; IL17 signaling pathway; Signaling Pathways in Glioblastoma; B Cell Receptor Signaling Pathway; TNF alpha Signaling Pathway; AGE/RAGE pathway; Interleukin-11 Signaling Pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Alpha 6 Beta 4 signaling pathway; Apoptosis; Primary Focal Segmental Glomerulosclerosis FSGS; T-Cell Receptor and Co-stimulatory Signaling; Signal Transduction of S1P Receptor; Cardiac Hypertrophic Response; IL-3 Signaling Pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Extracellular vesicle-mediated signaling in recipient cells; Kit receptor signaling pathway; Focal Adhesion; Copper homeostasis; Rac1/Pak1/p38/MMP-2 pathway; Mecp2 and Associated Rett Syndrome; Wnt Signaling Pathway Netpath; IL-6 signaling pathway; Hepatitis C and Hepatocellular Carcinoma; Pathways Affected in Adenoid Cystic Carcinoma; Wnt/beta-catenin Signaling Pathway in Leukemia; TGF-beta Signaling Pathway; BDNF-TrkB Signaling; Association Between Physico-Chemical Features and Toxicity Associated Pathways; MAPK Signaling Pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition; T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection; Regulation of Apoptosis by Parathyroid Hormone-related Protein; 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; Chemokine signaling pathway; ESC Pluripotency Pathways; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Leptin Insulin Overlap; IL-4 Signaling Pathway; EGF/EGFR Signaling Pathway; Endochondral Ossification; Insulin Signaling; IL-2 Signaling Pathway; EPO Receptor Signaling; Notch Signaling Pathway; T-Cell antigen Receptor (TCR)  Signaling Pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway","Regulation of PTEN stability and activity; mTOR signalling; KSRP (KHSRP) binds and destabilizes mRNA; CTLA4 inhibitory signaling; G beta:gamma signalling through PI3Kgamma; Translocation of GLUT4 to the plasma membrane; AKT phosphorylates targets in the nucleus; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; AKT phosphorylates targets in the cytosol; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Regulation of TP53 Activity through Association with Co-factors; Regulation of TP53 Activity through Acetylation; Regulation of TP53 Degradation; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; Integrin alphaIIb beta3 signaling; Activation of BAD and translocation to mitochondria ; RAB GEFs exchange GTP for GDP on RABs; Constitutive Signaling by AKT1 E17K in Cancer; Downregulation of ERBB2:ERBB3 signaling; eNOS activation; Deactivation of the beta-catenin transactivating complex; Cyclin E associated events during G1/S transition ; GPVI-mediated activation cascade; CD28 dependent PI3K/Akt signaling; AKT-mediated inactivation of FOXO1A; VEGFR2 mediated vascular permeability; RUNX2 regulates genes involved in cell migration; TP53 Regulates Metabolic Genes; Interleukin-4 and 13 signaling",233,High,1
Q9UL18,Protein argonaute-1 OS=Homo sapiens OX=9606 GN=AGO1 PE=1 SV=3,0,80.011,23,15,109,8,857,97.2,9.16,44101,0,14,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;DNA binding;protein binding;RNA binding,"Pf02170, Pf02171, Pf08699",26523,ENSG00000092847.11,AGO1; EIF2C1,1,,,Post-transcriptional silencing by small RNAs; Ca2+ pathway; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; MicroRNA (miRNA) biogenesis; Competing endogenous RNAs (ceRNAs) regulate PTEN translation; Small interfering RNA (siRNA) biogenesis; Transcriptional regulation by small RNAs; Regulation of RUNX1 Expression and Activity; MAPK6/MAPK4 signaling; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Pre-NOTCH Transcription and Translation; Oxidative Stress Induced Senescence,32,High,1
Q6XQN6,Nicotinate phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=NAPRT PE=1 SV=2,0,79.969,28,13,103,13,538,57.5,5.68,46582,0,13,1,metabolic process;response to stimulus;transport,cytoplasm;cytosol;extracellular;organelle lumen,catalytic activity;protein binding,Pf04095,93100,ENSG00000278488.2; ENSG00000147813.15,NAPRT1; NAPRT,8; CHR_HSCHR8_3_CTG7,Metabolic pathways; Nicotinate and nicotinamide metabolism,NAD+ biosynthetic pathways,Neutrophil degranulation; Nicotinamide salvaging,11,High,1
Q15661,Tryptase alpha/beta-1 OS=Homo sapiens OX=9606 GN=TPSAB1 PE=1 SV=1,0,79.934,25,7,225,6,275,30.5,7.11,101893,0,7,1,cell organization and biogenesis;defense response;metabolic process;response to stimulus,extracellular,catalytic activity;protein binding,Pf00089,7177; 64499,ENSG00000172236.16,TPSAB1; TPSB2,16,,,Activation of Matrix Metalloproteinases,3,High,1
Q9NUL3,Double-stranded RNA-binding protein Staufen homolog 2 OS=Homo sapiens OX=9606 GN=STAU2 PE=1 SV=2,0,79.916,36,15,99,14,570,62.6,9.61,38472,,15,,,,,,,,,,,,,0,High,1
Q96DE0,U8 snoRNA-decapping enzyme OS=Homo sapiens OX=9606 GN=NUDT16 PE=1 SV=2,0,79.906,57,10,116,8,195,21.3,6.89,58031,,10,,metabolic process;regulation of biological process,cytoplasm;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding,,131870,ENSG00000198585.11,NUDT16,3,RNA degradation; Purine metabolism,,Phosphate bond hydrolysis by NUDT proteins,7,High,1
Q9UG63,ATP-binding cassette sub-family F member 2 OS=Homo sapiens OX=9606 GN=ABCF2 PE=1 SV=2,0,79.883,22,13,80,13,623,71.2,7.37,33383,,13,,transport,membrane;mitochondrion,catalytic activity;nucleotide binding;transporter activity,"Pf00005, Pf12848",10061,ENSG00000033050.7,ABCF2,7,,,,0,High,1
P00326,Alcohol dehydrogenase 1C OS=Homo sapiens OX=9606 GN=ADH1C PE=1 SV=2,0,79.791,32,10,204,2,375,39.8,8.29,82531,73.94,7,3,metabolic process,cytoplasm;cytosol;membrane,catalytic activity;metal ion binding,"Pf00107, Pf08240",126,ENSG00000248144.5,ADH1C,4,Chemical carcinogenesis; Fatty acid degradation; Metabolic pathways; Retinol metabolism; Tyrosine metabolism; Glycolysis / Gluconeogenesis; Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450,Fatty Acid Omega Oxidation; Amino Acid metabolism,Ethanol oxidation; RA biosynthesis pathway,18,High,1
P43897,"Elongation factor Ts, mitochondrial OS=Homo sapiens OX=9606 GN=TSFM PE=1 SV=2",0,79.791,40,9,158,9,325,35.4,8.38,65237,,9,,metabolic process;regulation of biological process,mitochondrion;nucleus;organelle lumen,protein binding;RNA binding,"Pf00627, Pf00889",10102,ENSG00000123297.17,TSFM,12,,,Mitochondrial translation elongation,4,High,1
P63096,Guanine nucleotide-binding protein G(i) subunit alpha-1 OS=Homo sapiens OX=9606 GN=GNAI1 PE=1 SV=2,0,79.765,31,10,305,4,354,40.3,5.97,130628,,10,,cell division;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;membrane;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,"Pf00025, Pf00503",2770,ENSG00000127955.15,GNAI1,7,Progesterone-mediated oocyte maturation; Gastric acid secretion; Glutamatergic synapse; Retrograde endocannabinoid signaling; Pertussis; Regulation of lipolysis in adipocytes; Morphine addiction; Chemokine signaling pathway; Renin secretion; Cocaine addiction; Serotonergic synapse; Parkinson's disease; Gap junction; cAMP signaling pathway; Oxytocin signaling pathway; GABAergic synapse; Dopaminergic synapse; Toxoplasmosis; Cholinergic synapse; Rap1 signaling pathway; Sphingolipid signaling pathway; Adrenergic signaling in cardiomyocytes; Estrogen signaling pathway; cGMP-PKG signaling pathway; Leukocyte transendothelial migration; Pathways in cancer; Axon guidance; Tight junction; Long-term depression; Circadian entrainment; Alcoholism; Chagas disease (American trypanosomiasis); Melanogenesis; Platelet activation,Nicotine Activity on Dopaminergic Neurons; Human Thyroid Stimulating Hormone (TSH) signaling pathway; Endothelin Pathways; Corticotropin-releasing hormone signaling pathway; Signal Transduction of S1P Receptor; Common Pathways Underlying Drug Addiction; G Protein Signaling Pathways; Cell-type Dependent Selectivity of CCK2R Signaling; Chemokine signaling pathway; Calcium Regulation in the Cardiac Cell,"G alpha (z) signalling events; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G alpha (s) signalling events; PLC beta mediated events; ADP signalling through P2Y purinoceptor 12; Adrenaline,noradrenaline inhibits insulin secretion; Adenylate cyclase inhibitory pathway; G-protein activation",74,High,1
P27695,DNA-(apurinic or apyrimidinic site) lyase OS=Homo sapiens OX=9606 GN=APEX1 PE=1 SV=2,0,79.738,38,9,70,9,318,35.5,8.12,37379,,9,,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;endoplasmic reticulum;mitochondrion;nucleus;ribosome,catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding,"Pf03372, Pf14529",328,ENSG00000100823.11,APEX1,14,Base excision repair,Human Thyroid Stimulating Hormone (TSH) signaling pathway; Spinal Cord Injury,POLB-Dependent Long Patch Base Excision Repair; Displacement of DNA glycosylase by APEX1; PCNA-Dependent Long Patch Base Excision Repair; Abasic sugar-phosphate removal via the single-nucleotide replacement pathway,12,High,1
Q92506,Estradiol 17-beta-dehydrogenase 8 OS=Homo sapiens OX=9606 GN=HSD17B8 PE=1 SV=2,0,79.718,44,10,249,10,261,27,6.54,116213,15.11,8,3,cell organization and biogenesis;metabolic process,membrane;mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding,"Pf00106, Pf01370, Pf08659, Pf13561",7923,ENSG00000228712.2; ENSG00000225312.2; ENSG00000232357.2; ENSG00000112474.4; ENSG00000204228.3; ENSG00000228357.2,HSD17B8,6; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_MANN_CTG1,Metabolic pathways; Steroid hormone biosynthesis,,Fatty acyl-CoA biosynthesis,6,High,1
O75600,"2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial OS=Homo sapiens OX=9606 GN=GCAT PE=1 SV=1",0,79.648,28,9,89,9,419,45.3,8.05,38358,,9,,metabolic process,membrane;mitochondrion;nucleus,catalytic activity,"Pf00155, Pf00266",23464,ENSG00000100116.16,GCAT,22,"Glycine, serine and threonine metabolism",,Threonine catabolism,4,High,1
Q04760,Lactoylglutathione lyase OS=Homo sapiens OX=9606 GN=GLO1 PE=1 SV=4,0,79.647,57,10,466,10,184,20.8,5.31,230750,4.39,10,1,cell differentiation;metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;nucleus,catalytic activity;metal ion binding,"Pf00903, Pf12681, Pf13669",2739,ENSG00000124767.6,GLO1,6,Pyruvate metabolism,,Pyruvate metabolism,5,High,1
O00299,Chloride intracellular channel protein 1 OS=Homo sapiens OX=9606 GN=CLIC1 PE=1 SV=4,0,79.512,54,11,163,11,241,26.9,5.17,81162,3.88,10,2,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;membrane;mitochondrion;nucleus,catalytic activity;protein binding;transporter activity,"Pf00043, Pf13409, Pf13410, Pf13417",1192,ENSG00000213719.8; ENSG00000206394.8; ENSG00000230685.6; ENSG00000226248.6; ENSG00000223639.6; ENSG00000226651.6; ENSG00000226417.6,CLIC1,6; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_MCF_CTG1,,,,0,High,1
Q53EU6,Glycerol-3-phosphate acyltransferase 3 OS=Homo sapiens OX=9606 GN=GPAT3 PE=1 SV=2,0,79.508,25,9,66,9,434,48.7,8.87,28966,,9,,metabolic process;regulation of biological process,endoplasmic reticulum;membrane,catalytic activity,Pf01553,84803,ENSG00000138678.10,AGPAT9; GPAT3,4,Glycerophospholipid metabolism; Metabolic pathways; Glycerolipid metabolism,,Synthesis of PA,8,High,1
P50897,Palmitoyl-protein thioesterase 1 OS=Homo sapiens OX=9606 GN=PPT1 PE=1 SV=1,0,79.504,24,6,76,6,306,34.2,6.52,39837,,6,,cell communication;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;extracellular;Golgi;membrane;nucleus;organelle lumen;vacuole,catalytic activity;protein binding,Pf02089,5538,ENSG00000131238.16,PPT1,1,Metabolic pathways; Lysosome; Fatty acid metabolism; Fatty acid elongation,,Fatty acyl-CoA biosynthesis,8,High,1
O60684,Importin subunit alpha-7 OS=Homo sapiens OX=9606 GN=KPNA6 PE=1 SV=1,0,79.381,20,12,73,8,536,60,4.98,32763,0,12,1,regulation of biological process;transport,cytoplasm;cytosol;membrane;nucleus,protein binding;transporter activity,"Pf00514, Pf01749, Pf13513, Pf13646",23633,ENSG00000025800.13,KPNA6,1,,,,0,High,1
Q96IU4,Protein ABHD14B OS=Homo sapiens OX=9606 GN=ABHD14B PE=1 SV=1,0,79.349,40,7,118,7,210,22.3,6.4,61646,,7,,metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,"Pf00561, Pf12146, Pf12695, Pf12697",84836,ENSG00000114779.19,ABHD14B,3,,,Cytosolic sulfonation of small molecules,4,High,1
P41240,Tyrosine-protein kinase CSK OS=Homo sapiens OX=9606 GN=CSK PE=1 SV=1,0,79.339,35,13,78,12,450,50.7,7.06,38314,0,13,2,cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00017, Pf00018, Pf00069, Pf07653, Pf07714, Pf14604",1445,ENSG00000103653.16,CSK,15,Epithelial cell signaling in Helicobacter pylori infection,Integrin-mediated Cell Adhesion; VEGFA-VEGFR2 Signaling Pathway; Chemokine signaling pathway; EGF/EGFR Signaling Pathway; Regulation of Actin Cytoskeleton,PD-1 signaling; Signaling by BRAF and RAF fusions; Phosphorylation of CD3 and TCR zeta chains; MAP2K and MAPK activation; Integrin alphaIIb beta3 signaling; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; GAB1 signalosome; Interleukin-20 family signaling,36,High,1
Q9H0D6,5'-3' exoribonuclease 2 OS=Homo sapiens OX=9606 GN=XRN2 PE=1 SV=1,0,79.318,24,18,83,18,950,108.5,7.47,30477,,18,,cell differentiation;metabolic process;regulation of biological process,membrane;nucleus,catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding,Pf03159,22803,ENSG00000088930.7,XRN2,20,RNA degradation; Ribosome biogenesis in eukaryotes,mRNA Processing,Major pathway of rRNA processing in the nucleolus and cytosol; Association of TriC/CCT with target proteins during biosynthesis,11,High,1
P54098,DNA polymerase subunit gamma-1 OS=Homo sapiens OX=9606 GN=POLG PE=1 SV=1,0,79.302,21,18,58,18,1239,139.5,6.9,22097,,18,,cellular homeostasis;metabolic process;response to stimulus,mitochondrion,catalytic activity;DNA binding;protein binding,Pf00476,5428,ENSG00000140521.12,POLG,15,Metabolic pathways,Nucleotide Metabolism,,2,High,1
O95622,Adenylate cyclase type 5 OS=Homo sapiens OX=9606 GN=ADCY5 PE=1 SV=3,0,79.183,14,13,76,10,1261,138.8,7.24,22759,30.58,10,5,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cytoskeleton;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00211, Pf06327",111,ENSG00000173175.14,ADCY5,3,Bile secretion; Thyroid hormone synthesis; cAMP signaling pathway; Vascular smooth muscle contraction; Insulin secretion; Alcoholism; Progesterone-mediated oocyte maturation; Cocaine addiction; cGMP-PKG signaling pathway; Parkinson's disease; Cholinergic synapse; Ovarian steroidogenesis; Adrenergic signaling in cardiomyocytes; GnRH signaling pathway; Serotonergic synapse; Morphine addiction; Salivary secretion; Purine metabolism; Retrograde endocannabinoid signaling; Platelet activation; Amphetamine addiction; Pancreatic secretion; Estrogen signaling pathway; Oxytocin signaling pathway; Gastric acid secretion; Dilated cardiomyopathy; HTLV-I infection; Chemokine signaling pathway; Rap1 signaling pathway; Oocyte meiosis; Glutamatergic synapse; Gap junction; Endocrine resistance; Renin secretion; Aldosterone synthesis and secretion; Longevity regulating pathway; Longevity regulating pathway - multiple species; Pathways in cancer; Inflammatory mediator regulation of TRP channels; Phospholipase D signaling pathway; Melanogenesis; Regulation of lipolysis in adipocytes; Dopaminergic synapse; Circadian entrainment; GABAergic synapse,Myometrial Relaxation and Contraction Pathways; G Protein Signaling Pathways; Chemokine signaling pathway; Calcium Regulation in the Cardiac Cell,"Adenylate cyclase activating pathway; G alpha (z) signalling events; G alpha (s) signalling events; Adrenaline,noradrenaline inhibits insulin secretion; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Hedgehog 'off' state; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation in glucagon signalling; PKA activation; Adenylate cyclase inhibitory pathway",86,High,1
Q9BTW9,Tubulin-specific chaperone D OS=Homo sapiens OX=9606 GN=TBCD PE=1 SV=2,0,79.17,15,13,73,13,1192,132.5,6.19,27172,,13,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytoskeleton;membrane,enzyme regulator activity;protein binding,Pf12612,6904,ENSG00000141556.20,TBCD,17,,,Post-chaperonin tubulin folding pathway,3,High,1
P42229,Signal transducer and activator of transcription 5A OS=Homo sapiens OX=9606 GN=STAT5A PE=1 SV=1,0,79.095,20,12,61,3,794,90.6,6.39,23653,,12,,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus,catalytic activity;DNA binding;protein binding;signal transducer activity,"Pf00017, Pf01017, Pf02864, Pf02865",6776,ENSG00000126561.16,STAT5A,17,HTLV-I infection; Chronic myeloid leukemia; Viral carcinogenesis; Measles; Pathways in cancer; Hepatitis B; Acute myeloid leukemia; Prolactin signaling pathway; Jak-STAT signaling pathway; Th1 and Th2 cell differentiation; AGE-RAGE signaling pathway in diabetic complications; ErbB signaling pathway,IL-5 Signaling Pathway; Prolactin Signaling Pathway; IL-7 Signaling Pathway; IL-9 Signaling Pathway; AGE/RAGE pathway; Adipogenesis; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; IL-3 Signaling Pathway; Kit receptor signaling pathway; Rac1/Pak1/p38/MMP-2 pathway; Association Between Physico-Chemical Features and Toxicity Associated Pathways; TYROBP Causal Network; White fat cell differentiation; IL-4 Signaling Pathway; EGF/EGFR Signaling Pathway; IL-2 Signaling Pathway; EPO Receptor Signaling; Interferon type I signaling pathways; ErbB Signaling Pathway,"Interleukin-15 signaling; Interleukin-3, 5 and GM-CSF signaling; Signaling by Leptin; Signaling by cytosolic FGFR1 fusion mutants; Nuclear signaling by ERBB4; Signaling by SCF-KIT; Prolactin receptor signaling; Growth hormone receptor signaling; Interleukin-7 signaling; Downstream signal transduction",54,High,1
Q96I15,Selenocysteine lyase OS=Homo sapiens OX=9606 GN=SCLY PE=1 SV=4,0,79.086,43,12,87,12,445,48.1,7.12,30138,,12,,metabolic process,cytoplasm;cytosol,catalytic activity;protein binding,Pf00266,51540,,SCLY,2,Selenocompound metabolism; Metabolic pathways,Selenium Metabolism and Selenoproteins,"Metabolism of ingested SeMet, Sec, MeSec into H2Se",7,High,1
P19525,"Interferon-induced, double-stranded RNA-activated protein kinase OS=Homo sapiens OX=9606 GN=EIF2AK2 PE=1 SV=2",0,79.029,26,12,67,12,551,62.1,8.4,29050,,12,,cell communication;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus;ribosome,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding;RNA binding,"Pf00035, Pf00069, Pf07714",5610,ENSG00000055332.16,EIF2AK2,2,Hepatitis C; Viral carcinogenesis; Measles; Epstein-Barr virus infection; Influenza A; Herpes simplex infection; Protein processing in endoplasmic reticulum,Translation Factors; Type II interferon signaling (IFNG),Inhibition of PKR; ISG15 antiviral mechanism,20,High,1
Q6ZRY4,RNA-binding protein with multiple splicing 2 OS=Homo sapiens OX=9606 GN=RBPMS2 PE=1 SV=1,0,78.919,56,9,130,6,209,22.5,8.6,54665,3.76,9,2,development;regulation of biological process,cytoplasm,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",348093,ENSG00000166831.8,RBPMS2,15,,,,0,High,1
P38159,"RNA-binding motif protein, X chromosome OS=Homo sapiens OX=9606 GN=RBMX PE=1 SV=3",0,78.918,21,9,267,5,391,42.3,10.05,122522,,9,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,membrane;nucleus;spliceosomal complex,DNA binding;protein binding;RNA binding,"Pf00076, Pf08081, Pf13893, Pf14259",27316,ENSG00000147274.14,RBMX,X,Spliceosome,mRNA Processing,mRNA Splicing - Major Pathway,6,High,1
Q7Z794,"Keratin, type II cytoskeletal 1b OS=Homo sapiens OX=9606 GN=KRT77 PE=2 SV=3",0,78.903,16,14,511,6,578,61.9,5.99,260860,0,14,1,cell death;cell organization and biogenesis,cytoskeleton;cytosol,structural molecule activity,"Pf00038, Pf03962, Pf13166, Pf14817",374454,ENSG00000189182.9,KRT77,12,,,Formation of the cornified envelope,3,High,1
Q9P032,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 OS=Homo sapiens OX=9606 GN=NDUFAF4 PE=1 SV=1,0,78.877,53,10,198,10,175,20.3,8.82,97948,,10,,cell organization and biogenesis,membrane;mitochondrion,protein binding,Pf06784,29078,ENSG00000123545.5,NDUFAF4,6,,,Complex I biogenesis,5,High,1
Q9BSJ2,Gamma-tubulin complex component 2 OS=Homo sapiens OX=9606 GN=TUBGCP2 PE=1 SV=2,0,78.872,22,16,55,16,902,102.5,6.84,23055,,16,,cell organization and biogenesis,cytoplasm;cytoskeleton;cytosol;membrane,protein binding;structural molecule activity,Pf04130,10844,ENSG00000130640.13,TUBGCP2,10,,,Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes,9,High,1
Q9ULC4,Malignant T-cell-amplified sequence 1 OS=Homo sapiens OX=9606 GN=MCTS1 PE=1 SV=1,0,78.751,49,9,166,9,181,20.5,8.82,79326,2.29,9,2,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,protein binding;RNA binding,Pf01472,28985,ENSG00000232119.7,MCTS1,X,,,,0,High,1
O76094,Signal recognition particle subunit SRP72 OS=Homo sapiens OX=9606 GN=SRP72 PE=1 SV=3,0,78.711,25,14,66,14,671,74.6,9.26,26304,,14,,cell organization and biogenesis;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum,protein binding;RNA binding,"Pf08492, Pf12569, Pf12895, Pf13424, Pf14559",6731,ENSG00000174780.15,SRP72,4,Protein export,,SRP-dependent cotranslational protein targeting to membrane,4,High,1
P20340-2,Isoform 2 of Ras-related protein Rab-6A OS=Homo sapiens OX=9606 GN=RAB6A,0,78.69,59,12,247,1,208,23.5,5.54,119211,1.93,12,2,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;Golgi;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf02421, Pf04670, Pf08477, Pf09439",5870,ENSG00000175582.19,RAB6A,11,,,,0,High,1
Q14103,Heterogeneous nuclear ribonucleoprotein D0 OS=Homo sapiens OX=9606 GN=HNRNPD PE=1 SV=1,0,78.66,25,9,230,7,355,38.4,7.81,117348,0,9,1,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,DNA binding;protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",3184,ENSG00000138668.18,HNRNPD,4,,mRNA Processing,mRNA Splicing - Major Pathway,5,High,1
Q9NZB8,Molybdenum cofactor biosynthesis protein 1 OS=Homo sapiens OX=9606 GN=MOCS1 PE=1 SV=3,0,78.604,28,15,124,15,636,70.1,9.26,53967,16.77,15,1,metabolic process,cytosol;nucleus,catalytic activity;metal ion binding;nucleotide binding,"Pf01967, Pf04055, Pf06463, Pf13394",4337,ENSG00000124615.17,MOCS1,6,Folate biosynthesis; Metabolic pathways,,Molybdenum cofactor biosynthesis,6,High,1
Q96C23,Aldose 1-epimerase OS=Homo sapiens OX=9606 GN=GALM PE=1 SV=1,0,78.603,42,10,148,10,342,37.7,6.65,66153,,10,,metabolic process,cytoplasm,catalytic activity,Pf01263,130589,ENSG00000143891.16,GALM,2,Galactose metabolism; Glycolysis / Gluconeogenesis; Metabolic pathways,,,3,High,1
O15460,Prolyl 4-hydroxylase subunit alpha-2 OS=Homo sapiens OX=9606 GN=P4HA2 PE=1 SV=1,0,78.558,34,13,49,12,535,60.9,5.71,21672,,13,,metabolic process,cytosol;endoplasmic reticulum;organelle lumen,catalytic activity;metal ion binding;protein binding,"Pf03171, Pf08336, Pf13640",8974,ENSG00000072682.18,P4HA2,5,Arginine and proline metabolism; Metabolic pathways,Amino Acid metabolism,Collagen biosynthesis and modifying enzymes,6,High,1
O43847,Nardilysin OS=Homo sapiens OX=9606 GN=NRDC PE=1 SV=3,0,78.533,14,14,64,14,1151,131.6,4.98,27223,,14,,,,,,,,,,,,,0,High,1
P43652,Afamin OS=Homo sapiens OX=9606 GN=AFM PE=1 SV=1,0,78.513,26,13,144,13,599,69,5.9,61447,,13,,transport,extracellular,,Pf00273,173,ENSG00000079557.4,AFM,4,,,,0,High,1
Q9BXW6,Oxysterol-binding protein-related protein 1 OS=Homo sapiens OX=9606 GN=OSBPL1A PE=1 SV=2,0,78.324,17,11,77,11,950,108.4,6.38,31407,4.47,10,1,metabolic process;transport,cytosol;endosome,protein binding;transporter activity,"Pf00023, Pf00169, Pf01237, Pf12796, Pf13606, Pf13637, Pf13857",114876,ENSG00000141447.17,OSBPL1A,18,,,Synthesis of bile acids and bile salts; MHC class II antigen presentation,8,High,1
P02792,Ferritin light chain OS=Homo sapiens OX=9606 GN=FTL PE=1 SV=2,0,78.196,35,5,162,5,175,20,5.78,86523,,5,,cellular homeostasis;transport,cytosol;extracellular;membrane;organelle lumen;vacuole,metal ion binding;protein binding,Pf00210,2512,ENSG00000087086.14,FTL,19,Mineral absorption,NRF2 pathway,Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Iron uptake and transport; Scavenging by Class A Receptors,14,High,1
P52294,Importin subunit alpha-5 OS=Homo sapiens OX=9606 GN=KPNA1 PE=1 SV=3,0,78.182,20,10,62,6,538,60.2,5.01,31214,0,10,1,metabolic process;regulation of biological process;transport,cytoplasm;cytosol;nucleus,protein binding;transporter activity,"Pf00514, Pf01749, Pf13513, Pf13646",3836,ENSG00000114030.12,KPNA1,3,Influenza A,,Integration of provirus; ISG15 antiviral mechanism;  NS1 Mediated Effects on Host Pathways; Vpr-mediated nuclear import of PICs; Transport of Ribonucleoproteins into the Host Nucleus; Activation of DNA fragmentation factor,25,High,1
O60701,UDP-glucose 6-dehydrogenase OS=Homo sapiens OX=9606 GN=UGDH PE=1 SV=1,0,78.121,38,14,83,14,494,55,7.12,33892,,14,,metabolic process,cytosol;nucleus,catalytic activity;nucleotide binding,"Pf00984, Pf03720, Pf03721",7358,ENSG00000109814.11,UGDH,4,Metabolic pathways; Amino sugar and nucleotide sugar metabolism; Pentose and glucuronate interconversions; Ascorbate and aldarate metabolism,Glucuronidation,"Formation of the active cofactor, UDP-glucuronate",10,High,1
Q96IX5,"ATP synthase membrane subunit DAPIT, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5MD PE=1 SV=1",0,78.097,47,7,240,7,58,6.5,9.76,136624,,7,,,membrane;mitochondrion,,Pf14960,84833,ENSG00000173915.14,USMG5,10,,,,0,High,1
Q92783,Signal transducing adapter molecule 1 OS=Homo sapiens OX=9606 GN=STAM PE=1 SV=3,0,78.086,29,10,62,9,540,59.1,4.82,29517,,10,,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane,protein binding,"Pf00018, Pf00790, Pf07653, Pf14604",8027,ENSG00000136738.14,STAM,10,Jak-STAT signaling pathway; Endocytosis,VEGFA-VEGFR2 Signaling Pathway; EGF/EGFR Signaling Pathway,Cargo recognition for clathrin-mediated endocytosis; Negative regulation of MET activity; EGFR downregulation; InlB-mediated entry of Listeria monocytogenes into host cell; Metalloprotease DUBs; Endosomal Sorting Complex Required For Transport (ESCRT),23,High,1
Q13326,Gamma-sarcoglycan OS=Homo sapiens OX=9606 GN=SGCG PE=1 SV=4,0,78.049,28,6,221,6,291,32.4,5.97,107528,28.6,6,2,cell organization and biogenesis,cytoplasm;cytoskeleton;membrane,protein binding,Pf04790,6445,ENSG00000102683.7,SGCG,13,Viral myocarditis; Hypertrophic cardiomyopathy (HCM); Arrhythmogenic right ventricular cardiomyopathy (ARVC); Dilated cardiomyopathy,Arrhythmogenic Right Ventricular Cardiomyopathy,,5,High,1
Q86SQ0,Pleckstrin homology-like domain family B member 2 OS=Homo sapiens OX=9606 GN=PHLDB2 PE=1 SV=2,0,78.031,18,17,58,16,1253,142.1,7.43,25411,0,17,1,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;Golgi;membrane,catalytic activity;motor activity;protein binding,"Pf00169, Pf01576, Pf02463, Pf03938, Pf04111, Pf04156, Pf05483, Pf05667, Pf09730, Pf09731, Pf12128, Pf13166, Pf13851, Pf13868, Pf14942, Pf14943, Pf14992",90102,ENSG00000144824.20,PHLDB2,3,,Regulation of Microtubule Cytoskeleton,,1,High,1
Q96T76,MMS19 nucleotide excision repair protein homolog OS=Homo sapiens OX=9606 GN=MMS19 PE=1 SV=2,0,77.969,20,14,89,14,1030,113.2,6.35,38601,,14,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,protein binding;structural molecule activity,"Pf12460, Pf14500",64210,ENSG00000155229.20,MMS19,10,,,Cytosolic iron-sulfur cluster assembly,2,High,1
O43708,Maleylacetoacetate isomerase OS=Homo sapiens OX=9606 GN=GSTZ1 PE=1 SV=3,0,77.834,44,10,200,10,216,24.2,8.54,91912,3.96,9,1,metabolic process,cytoplasm;cytosol;mitochondrion,antioxidant activity;catalytic activity;protein binding,"Pf00043, Pf02798, Pf13409, Pf13417",2954,,GSTZ1,14,Tyrosine metabolism; Metabolic pathways,Metapathway biotransformation,Glutathione conjugation; Phenylalanine and tyrosine catabolism,10,High,1
P22087,rRNA 2'-O-methyltransferase fibrillarin OS=Homo sapiens OX=9606 GN=FBL PE=1 SV=2,0,77.831,37,10,113,10,321,33.8,10.18,52682,,10,,cell differentiation;cell organization and biogenesis;metabolic process,chromosome;membrane;nucleus,catalytic activity;protein binding;RNA binding,"Pf01135, Pf01269, Pf13847",2091,ENSG00000280548.3; ENSG00000105202.8,FBL,19; CHR_HG2021_PATCH,Ribosome biogenesis in eukaryotes,,Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol,6,High,1
Q9C0E8,Endoplasmic reticulum junction formation protein lunapark OS=Homo sapiens OX=9606 GN=LNPK PE=1 SV=2,0,77.819,31,10,68,10,428,47.7,5.11,29974,,10,,cell organization and biogenesis;coagulation;development;regulation of biological process,endoplasmic reticulum;membrane,metal ion binding;protein binding,Pf10058,80856,ENSG00000144320.13,KIAA1715; LNPK,2,,,,0,High,1
Q14669,E3 ubiquitin-protein ligase TRIP12 OS=Homo sapiens OX=9606 GN=TRIP12 PE=1 SV=1,0,77.779,10,15,62,15,1992,220.3,8.48,26537,,15,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,"Pf00632, Pf02825",9320,ENSG00000153827.13,TRIP12,2,Ubiquitin mediated proteolysis,,Antigen processing: Ubiquitination & Proteasome degradation,5,High,1
P00736,Complement C1r subcomponent OS=Homo sapiens OX=9606 GN=C1R PE=1 SV=2,0,77.724,17,9,100,9,705,80.1,6.21,44981,0,9,1,defense response;metabolic process;regulation of biological process;response to stimulus,extracellular,catalytic activity;metal ion binding;protein binding,"Pf00084, Pf00089, Pf00431, Pf07645, Pf12662, Pf14670",715,,C1R,12,Systemic lupus erythematosus; Staphylococcus aureus infection; Pertussis; Phagosome; Complement and coagulation cascades,Complement and Coagulation Cascades,Regulation of Complement cascade; Classical antibody-mediated complement activation,13,High,1
Q68CZ2,Tensin-3 OS=Homo sapiens OX=9606 GN=TNS3 PE=1 SV=2,0,77.694,14,12,109,10,1445,155.2,6.81,50743,0,12,1,cellular component movement;regulation of biological process,cytosol,protein binding,"Pf00017, Pf08416, Pf10409",64759,ENSG00000136205.16,TNS3,7,,,MET interacts with TNS proteins,5,High,1
Q8WVC6,Dephospho-CoA kinase domain-containing protein OS=Homo sapiens OX=9606 GN=DCAKD PE=1 SV=1,0,77.618,48,11,94,11,231,26.5,9.58,39433,,11,,metabolic process,membrane;mitochondrion,catalytic activity;nucleotide binding,"Pf01121, Pf13189",79877,ENSG00000172992.11,DCAKD,17,,,,0,High,1
Q9NP97,Dynein light chain roadblock-type 1 OS=Homo sapiens OX=9606 GN=DYNLRB1 PE=1 SV=3,0,77.602,82,8,122,8,96,10.9,7.25,52962,33.33,7,2,cellular component movement;response to stimulus;transport,cytoplasm;cytoskeleton;membrane,catalytic activity;motor activity;protein binding,Pf03259,83658,ENSG00000125971.16,DYNLRB1,20,,,Intraflagellar transport,3,High,1
Q8TAE8,Growth arrest and DNA damage-inducible proteins-interacting protein 1 OS=Homo sapiens OX=9606 GN=GADD45GIP1 PE=1 SV=1,0,77.543,50,8,94,8,222,25.4,10.02,47249,,8,,cell organization and biogenesis;metabolic process;regulation of biological process,mitochondrion;nucleus;organelle lumen;ribosome,protein binding,Pf10147,90480,ENSG00000179271.2,GADD45GIP1,19,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
O43674,"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFB5 PE=1 SV=1",0,77.534,26,7,499,7,189,21.7,9.63,228447,1.62,7,2,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion,catalytic activity,Pf09781,4711,ENSG00000136521.12,NDUFB5,3,Parkinson's disease; Non-alcoholic fatty liver disease (NAFLD); Alzheimer's disease; Huntington's disease; Metabolic pathways; Oxidative phosphorylation,Electron Transport Chain; Oxidative phosphorylation,Complex I biogenesis,13,High,1
O75688,Protein phosphatase 1B OS=Homo sapiens OX=9606 GN=PPM1B PE=1 SV=1,0,77.504,31,10,114,7,479,52.6,5.05,51768,0,10,1,metabolic process;regulation of biological process,cytoplasm;cytosol;membrane,catalytic activity;metal ion binding;protein binding,"Pf00481, Pf07830, Pf13672",5495,ENSG00000138032.20,PPM1B,2,MAPK signaling pathway,MAPK Signaling Pathway,ISG15 antiviral mechanism,7,High,1
Q8N8S7,Protein enabled homolog OS=Homo sapiens OX=9606 GN=ENAH PE=1 SV=2,0,77.503,25,12,69,12,591,66.5,6.93,30685,,12,,cellular component movement,cytoplasm;cytoskeleton;cytosol;membrane,protein binding,"Pf00568, Pf08776",55740,ENSG00000154380.17,ENAH,1,Regulation of actin cytoskeleton; Axon guidance,Regulation of Actin Cytoskeleton,Generation of second messenger molecules; Signaling by ROBO receptors,10,High,1
P50336,Protoporphyrinogen oxidase OS=Homo sapiens OX=9606 GN=PPOX PE=1 SV=1,0,77.327,34,13,103,13,477,50.7,8.16,43486,,13,,metabolic process;response to stimulus,membrane;mitochondrion,catalytic activity;nucleotide binding,"Pf01266, Pf01593, Pf13450",5498,ENSG00000143224.17,PPOX,1,Metabolic pathways; Porphyrin and chlorophyll metabolism,Heme Biosynthesis,Heme biosynthesis,6,High,1
Q08AM6,Protein VAC14 homolog OS=Homo sapiens OX=9606 GN=VAC14 PE=1 SV=1,0,77.322,19,12,95,12,782,87.9,6.13,43200,,12,,metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;endosome;membrane,protein binding;receptor activity,"Pf11916, Pf12755",55697,ENSG00000103043.14,VAC14,16,Viral carcinogenesis; HTLV-I infection,,Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane,9,High,1
O75368,SH3 domain-binding glutamic acid-rich-like protein OS=Homo sapiens OX=9606 GN=SH3BGRL PE=1 SV=1,0,77.203,70,6,194,6,114,12.8,5.25,102722,3.67,6,2,cellular homeostasis;regulation of biological process,cytoplasm;nucleus,catalytic activity;protein binding,"Pf00462, Pf04908",6451,ENSG00000131171.12,SH3BGRL,X,,,,0,High,1
O96005,Cleft lip and palate transmembrane protein 1 OS=Homo sapiens OX=9606 GN=CLPTM1 PE=1 SV=1,0,77.201,21,11,79,11,669,76,6.3,38977,0,11,1,cell differentiation;development;regulation of biological process,membrane,protein binding,Pf05602,1209,ENSG00000104853.15,CLPTM1,19,,,,0,High,1
Q16643,Drebrin OS=Homo sapiens OX=9606 GN=DBN1 PE=1 SV=4,0,77.083,27,11,44,11,649,71.4,4.45,23011,0,11,1,cell communication;cell differentiation;cell organization and biogenesis;cell proliferation;development;regulation of biological process,cytoplasm;cytoskeleton;membrane,protein binding,Pf00241,1627,ENSG00000113758.13,DBN1,5,,,,0,High,1
Q8N5N7,"39S ribosomal protein L50, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL50 PE=1 SV=2",0,77,49,6,82,6,158,18.3,7.88,42574,,6,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,,Pf10501,54534,ENSG00000136897.7,MRPL50,9,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
P78318,Immunoglobulin-binding protein 1 OS=Homo sapiens OX=9606 GN=IGBP1 PE=1 SV=1,0,76.978,49,12,63,12,339,39.2,5.38,26447,,12,,regulation of biological process;response to stimulus,cytoplasm;cytosol,enzyme regulator activity;protein binding,Pf04177,3476,ENSG00000089289.15,IGBP1,X,,,,0,High,1
Q96I24,Far upstream element-binding protein 3 OS=Homo sapiens OX=9606 GN=FUBP3 PE=1 SV=2,0,76.914,38,14,62,12,572,61.6,8.38,24959,,14,,metabolic process;regulation of biological process,cytoplasm;membrane;nucleus,DNA binding;protein binding;RNA binding,"Pf00013, Pf07650, Pf13014",8939,ENSG00000107164.15,FUBP3,9,,,,0,High,1
O14949,Cytochrome b-c1 complex subunit 8 OS=Homo sapiens OX=9606 GN=UQCRQ PE=1 SV=4,0,76.825,63,11,942,11,82,9.9,10.08,515664,,11,,metabolic process;transport,membrane;mitochondrion,catalytic activity;transporter activity,"Pf02939, Pf13166",27089,ENSG00000164405.10,UQCRQ,5,Metabolic pathways; Parkinson's disease; Oxidative phosphorylation; Cardiac muscle contraction; Non-alcoholic fatty liver disease (NAFLD); Alzheimer's disease; Huntington's disease,Electron Transport Chain,Respiratory electron transport,12,High,1
O14787-2,Isoform 2 of Transportin-2 OS=Homo sapiens OX=9606 GN=TNPO2,0,76.792,21,13,161,7,887,100.3,4.98,68062,0,13,1,transport,cytoplasm;membrane;nucleus,protein binding;transporter activity,"Pf03810, Pf13513",30000,ENSG00000105576.15,TNPO2,19,,,,0,High,1
Q9UJ68,Mitochondrial peptide methionine sulfoxide reductase OS=Homo sapiens OX=9606 GN=MSRA PE=1 SV=1,0,76.763,38,6,103,6,235,26.1,8.09,46969,,6,,metabolic process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus,catalytic activity,Pf01625,4482,ENSG00000175806.14,MSRA,8,,Sulindac Metabolic Pathway,Protein repair,3,High,1
Q92896,Golgi apparatus protein 1 OS=Homo sapiens OX=9606 GN=GLG1 PE=1 SV=2,0,76.753,12,13,71,13,1179,134.5,6.9,29605,,13,,cellular component movement;regulation of biological process,Golgi;membrane,protein binding,Pf00839,2734,ENSG00000090863.11,GLG1,16,Cell adhesion molecules (CAMs),,Cell surface interactions at the vascular wall,3,High,1
P55822,SH3 domain-binding glutamic acid-rich protein OS=Homo sapiens OX=9606 GN=SH3BGR PE=2 SV=3,0,76.666,32,8,245,8,239,26.1,4.15,116567,27.74,5,4,cell organization and biogenesis;regulation of biological process,cytosol,protein binding,Pf04908,6450,ENSG00000185437.13,SH3BGR,21,,,,0,High,1
Q7L7V1,Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 OS=Homo sapiens OX=9606 GN=DHX32 PE=1 SV=1,0,76.662,23,12,68,12,743,84.4,4.97,32348,,12,,metabolic process,cytoplasm;mitochondrion;nucleus;spliceosomal complex,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf04408, Pf07717",55760,ENSG00000089876.11,DHX32,10,,,,0,High,1
Q07002,Cyclin-dependent kinase 18 OS=Homo sapiens OX=9606 GN=CDK18 PE=1 SV=4,0,76.661,27,9,72,9,474,54.4,8.66,29126,11.27,9,2,,,,,,,,,,,,0,High,1
Q13642-1,Isoform 1 of Four and a half LIM domains protein 1 OS=Homo sapiens OX=9606 GN=FHL1,0,76.657,30,11,631,11,280,31.9,8.32,220932,314.4,8,4,cell differentiation;regulation of biological process,cytoplasm;cytosol;membrane;nucleus,metal ion binding;protein binding,Pf00412,2273,ENSG00000022267.16,FHL1,X,,Notch Signaling Pathway,,1,High,1
P01889,"HLA class I histocompatibility antigen, B alpha chain OS=Homo sapiens OX=9606 GN=HLA-B PE=1 SV=3",0,76.621,31,10,99,4,362,40.4,5.85,51470,,10,,regulation of biological process;response to stimulus;transport,cell surface;endoplasmic reticulum;Golgi;membrane,protein binding,"Pf00129, Pf06623, Pf07654",3106,ENSG00000234745.10,HLA-B,6,Epstein-Barr virus infection; Viral carcinogenesis; Viral myocarditis; Phagosome; Cell adhesion molecules (CAMs); Allograft rejection; Antigen processing and presentation; Herpes simplex infection; HTLV-I infection; Type I diabetes mellitus; Endocytosis; Graft-versus-host disease; Autoimmune thyroid disease; Natural killer cell mediated cytotoxicity,Proteasome Degradation; Allograft Rejection; Type II interferon signaling (IFNG),"Interferon alpha/beta signaling; ER-Phagosome pathway; Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Endosomal/Vacuolar pathway; Interferon gamma signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC",31,High,1
P51692,Signal transducer and activator of transcription 5B OS=Homo sapiens OX=9606 GN=STAT5B PE=1 SV=2,0,76.606,23,13,72,4,787,89.8,6.05,27890,,13,,cell differentiation;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus,catalytic activity;DNA binding;protein binding;signal transducer activity,"Pf00017, Pf01017, Pf02864, Pf02865",6777,ENSG00000173757.9,STAT5B,17,Acute myeloid leukemia; Th1 and Th2 cell differentiation; Chemokine signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Prolactin signaling pathway; Jak-STAT signaling pathway; ErbB signaling pathway; Chronic myeloid leukemia; Measles; Hepatitis B; HTLV-I infection; Viral carcinogenesis; Pathways in cancer,IL-5 Signaling Pathway; Leptin signaling pathway; Prolactin Signaling Pathway; IL-7 Signaling Pathway; IL-9 Signaling Pathway; AGE/RAGE pathway; Adipogenesis; Oncostatin M Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; IL-3 Signaling Pathway; Kit receptor signaling pathway; Rac1/Pak1/p38/MMP-2 pathway; Chemokine signaling pathway; White fat cell differentiation; IL-4 Signaling Pathway; EGF/EGFR Signaling Pathway; Endochondral Ossification; IL-2 Signaling Pathway; EPO Receptor Signaling,"Interleukin-15 signaling; Interleukin-3, 5 and GM-CSF signaling; Signaling by Leptin; Signaling by cytosolic FGFR1 fusion mutants; Signaling by SCF-KIT; Prolactin receptor signaling; Growth hormone receptor signaling; Interleukin-7 signaling; Downstream signal transduction",53,High,1
Q9Y2S2,Lambda-crystallin homolog OS=Homo sapiens OX=9606 GN=CRYL1 PE=1 SV=3,0,76.6,31,9,124,9,319,35.4,6.18,57792,,9,,metabolic process,cytoplasm;cytosol,catalytic activity;nucleotide binding;protein binding,"Pf00725, Pf02737",51084,ENSG00000165475.13,CRYL1,13,Pentose and glucuronate interconversions; Metabolic pathways,,Catabolism of glucuronate to xylulose-5-phosphate,5,High,1
Q02153,Guanylate cyclase soluble subunit beta-1 OS=Homo sapiens OX=9606 GN=GUCY1B1 PE=1 SV=1,0,76.538,25,12,72,12,619,70.5,5.35,27630,11.09,12,1,metabolic process;regulation of biological process;response to stimulus,cytoplasm;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding;receptor activity,"Pf00211, Pf07700, Pf07701",2983,ENSG00000061918.12,GUCY1B3,4,Gap junction; Renin secretion; Platelet activation; Oxytocin signaling pathway; Vascular smooth muscle contraction; Long-term depression; Circadian entrainment; Purine metabolism; cGMP-PKG signaling pathway; Salivary secretion,,Nitric oxide stimulates guanylate cyclase,13,High,1
P05976,"Myosin light chain 1/3, skeletal muscle isoform OS=Homo sapiens OX=9606 GN=MYL1 PE=1 SV=3",0,76.528,32,10,1438,1,194,21.1,5.03,744934,0,10,2,cellular component movement,cytosol,metal ion binding;structural molecule activity,"Pf13405, Pf13499",4632,ENSG00000168530.15,MYL1,2,,Endothelin Pathways; Association Between Physico-Chemical Features and Toxicity Associated Pathways; Striated Muscle Contraction; Regulation of Actin Cytoskeleton; G13 Signaling Pathway,Striated Muscle Contraction,7,High,1
Q9GZT8,NIF3-like protein 1 OS=Homo sapiens OX=9606 GN=NIF3L1 PE=1 SV=2,0,76.487,34,11,115,11,377,41.9,6.65,50650,,11,,cell differentiation;regulation of biological process,cytoplasm;mitochondrion;nucleus,protein binding,Pf01784,60491,ENSG00000196290.14,NIF3L1,2,,,,0,High,1
Q17RY0,Cytoplasmic polyadenylation element-binding protein 4 OS=Homo sapiens OX=9606 GN=CPEB4 PE=1 SV=1,0,76.458,27,14,73,9,729,80.1,7.18,31103,,14,,cell communication;metabolic process;regulation of biological process;response to stimulus,cytoplasm;endoplasmic reticulum;membrane;nucleus,metal ion binding;protein binding;RNA binding;translation regulator activity,"Pf00076, Pf14259",80315,ENSG00000113742.12,CPEB4,5,Progesterone-mediated oocyte maturation; Oocyte meiosis; Dorso-ventral axis formation,,,3,High,1
P50225,Sulfotransferase 1A1 OS=Homo sapiens OX=9606 GN=SULT1A1 PE=1 SV=3,0,76.443,45,12,109,5,295,34.1,6.62,50283,,12,,metabolic process,cytoplasm;cytosol,catalytic activity;protein binding,Pf00685,6817,ENSG00000196502.11,SULT1A1,16,Chemical carcinogenesis,Constitutive Androstane Receptor Pathway; Melatonin metabolism and effects; Tamoxifen metabolism; Sulfation Biotransformation Reaction; Arylamine metabolism; Estrogen metabolism; Metapathway biotransformation; Vitamin A and Carotenoid Metabolism,Cytosolic sulfonation of small molecules,13,High,1
P68402,Platelet-activating factor acetylhydrolase IB subunit beta OS=Homo sapiens OX=9606 GN=PAFAH1B2 PE=1 SV=1,0,76.374,37,6,111,6,229,25.6,5.92,63468,,6,,metabolic process;regulation of biological process;transport,cytoplasm;cytosol;extracellular;membrane;organelle lumen,catalytic activity;protein binding,"Pf00657, Pf13472",5049,ENSG00000168092.13,PAFAH1B2,11,Ether lipid metabolism; Metabolic pathways,,COPI-independent Golgi-to-ER retrograde traffic; Neutrophil degranulation,10,High,1
O75953,DnaJ homolog subfamily B member 5 OS=Homo sapiens OX=9606 GN=DNAJB5 PE=1 SV=1,0,76.296,39,12,73,12,348,39.1,9.04,32800,2.99,11,2,metabolic process;regulation of biological process;response to stimulus,cytosol;nucleus,protein binding,"Pf00226, Pf01556",25822,ENSG00000137094.14,DNAJB5,9,,,,0,High,1
P50453,Serpin B9 OS=Homo sapiens OX=9606 GN=SERPINB9 PE=1 SV=1,0,76.246,37,11,100,10,376,42.4,5.86,48668,0,11,1,cell death;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,enzyme regulator activity;protein binding,Pf00079,5272,ENSG00000170542.5,SERPINB9,6,Amoebiasis,,,1,High,1
Q9NRN7,L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase OS=Homo sapiens OX=9606 GN=AASDHPPT PE=1 SV=2,0,76.107,30,10,128,10,309,35.8,6.8,58557,0,10,1,metabolic process,cytoplasm;cytosol,catalytic activity;metal ion binding;protein binding,Pf01648,60496,ENSG00000149313.10,AASDHPPT,11,Pantothenate and CoA biosynthesis,,Vitamin B5 (pantothenate) metabolism,5,High,1
Q99757,"Thioredoxin, mitochondrial OS=Homo sapiens OX=9606 GN=TXN2 PE=1 SV=2",0,75.95,33,7,229,7,166,18.4,8.29,103101,,7,,cell communication;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,mitochondrion;organelle lumen,catalytic activity;protein binding,"Pf00085, Pf13098, Pf13899, Pf13905",25828,ENSG00000100348.9,TXN2,22,NOD-like receptor signaling pathway,Oxidative Stress,Detoxification of Reactive Oxygen Species,5,High,1
P02788,Lactotransferrin OS=Homo sapiens OX=9606 GN=LTF PE=1 SV=6,0,75.947,19,14,81,9,710,78.1,8.12,38379,,14,,cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;extracellular;nucleus;organelle lumen,catalytic activity;DNA binding;enzyme regulator activity;metal ion binding;protein binding,Pf00405,4057,ENSG00000012223.12,LTF,3,,,Neutrophil degranulation; Mtb iron assimilation by chelation; Amyloid fiber formation; Metal sequestration by antimicrobial proteins,12,High,1
Q9BZZ5,Apoptosis inhibitor 5 OS=Homo sapiens OX=9606 GN=API5 PE=1 SV=3,0,75.871,27,12,88,12,524,59,7.34,41009,,12,,cell death;regulation of biological process,cytoplasm;membrane;nucleus;spliceosomal complex,protein binding;RNA binding,"Pf05918, Pf13646",8539,ENSG00000166181.12,API5,11,,,,0,High,1
P53985,Monocarboxylate transporter 1 OS=Homo sapiens OX=9606 GN=SLC16A1 PE=1 SV=3,0,75.823,15,8,95,8,500,53.9,8.66,46084,2.14,7,2,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,membrane;mitochondrion,protein binding;transporter activity,"Pf00083, Pf07690, Pf12832",6566,ENSG00000281917.2; ENSG00000155380.11,SLC16A1,1; CHR_HG2104_PATCH,,Photodynamic therapy-induced HIF-1 survival signaling,Proton-coupled monocarboxylate transport; Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT); Basigin interactions; Pyruvate metabolism,16,High,1
Q02543,60S ribosomal protein L18a OS=Homo sapiens OX=9606 GN=RPL18A PE=1 SV=2,0,75.816,31,12,210,12,176,20.7,10.71,96848,,12,,cell organization and biogenesis;metabolic process;response to stimulus;transport,cytosol;membrane;ribosome,protein binding;RNA binding;structural molecule activity,Pf01775,6142,ENSG00000105640.12,RPL18A,19,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
Q12874,Splicing factor 3A subunit 3 OS=Homo sapiens OX=9606 GN=SF3A3 PE=1 SV=1,0,75.708,33,13,113,13,501,58.8,5.38,45805,0,13,1,cell organization and biogenesis;metabolic process,nucleus;spliceosomal complex,metal ion binding;protein binding;RNA binding,"Pf11931, Pf12108, Pf13297",10946,ENSG00000183431.11,SF3A3,1,Spliceosome,Exercise-induced Circadian Regulation; mRNA Processing,mRNA Splicing - Major Pathway,7,High,1
Q86TU7,Actin-histidine N-methyltransferase OS=Homo sapiens OX=9606 GN=SETD3 PE=1 SV=1,0,75.652,32,15,48,15,594,67.2,5.96,19796,0,15,1,cell organization and biogenesis;metabolic process;regulation of biological process,nucleus,catalytic activity;protein binding,"Pf00856, Pf09273",84193,ENSG00000183576.12,SETD3,14,Lysine degradation,Histone Modifications,PKMTs methylate histone lysines,5,High,1
P62714,Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform OS=Homo sapiens OX=9606 GN=PPP2CB PE=1 SV=1,0,75.637,33,7,209,7,309,35.6,5.43,97946,28.83,5,4,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;cytoskeleton;cytosol;nucleus,catalytic activity;metal ion binding;protein binding,Pf00149,5516,ENSG00000104695.12,PPP2CB,8,Adrenergic signaling in cardiomyocytes; TGF-beta signaling pathway; Sphingolipid signaling pathway; Long-term depression; Hippo signaling pathway; Chagas disease (American trypanosomiasis); PI3K-Akt signaling pathway; Oocyte meiosis; AMPK signaling pathway; Tight junction; Dopaminergic synapse; Hepatitis C; mRNA surveillance pathway,Serotonin Transporter Activity; Dopamine metabolism; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Wnt Signaling Pathway and Pluripotency; Exercise-induced Circadian Regulation; Glycogen Metabolism; Monoamine Transport,"Glycolysis; AXIN missense mutants destabilize the destruction complex; PP2A-mediated dephosphorylation of key metabolic factors; APC truncation mutants have impaired AXIN binding; CTLA4 inhibitory signaling; Activated TLR4 signalling; Separation of Sister Chromatids; MASTL Facilitates Mitotic Progression; S37 mutants of beta-catenin aren't phosphorylated; S33 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; Misspliced GSK3beta mutants stabilize beta-catenin; Cyclin A/B1/B2 associated events during G2/M transition; T41 mutants of beta-catenin aren't phosphorylated; RAF activation; ERKs are inactivated; Beta-catenin phosphorylation cascade; Negative regulation of MAPK pathway; Platelet sensitization by LDL; Signaling by GPCR; Interleukin-20 family signaling; Spry regulation of FGF signaling; DARPP-32 events; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Regulation of TP53 Degradation; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Cyclin D associated events in G1; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; Truncations of AMER1 destabilize the destruction complex",139,High,1
P26885,Peptidyl-prolyl cis-trans isomerase FKBP2 OS=Homo sapiens OX=9606 GN=FKBP2 PE=1 SV=2,0,75.634,47,6,190,6,142,15.6,9.13,89318,0,6,1,metabolic process,endoplasmic reticulum;membrane,catalytic activity;protein binding,Pf00254,2286,ENSG00000173486.12,FKBP2,11,,,,0,High,1
P84243,Histone H3.3 OS=Homo sapiens OX=9606 GN=H3-3A PE=1 SV=2,0,75.593,53,9,402,9,136,15.3,11.27,187241,15.84,8,1,cell differentiation;cell organization and biogenesis;cell proliferation;coagulation;metabolic process;regulation of biological process;response to stimulus,chromosome;extracellular;nucleus,DNA binding;protein binding,"Pf00125, Pf15630",3020; 440926; 3021,ENSG00000132475.10; ENSG00000163041.9,H3F3A; H3F3AP4; H3F3B,1; 2; 17,Systemic lupus erythematosus; Transcriptional misregulation in cancer; Alcoholism,Gastric Cancer Network 1; Histone Modifications,SIRT1 negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; NoRC negatively regulates rRNA expression; Factors involved in megakaryocyte development and platelet production; Transcriptional regulation by small RNAs; Meiotic recombination; PRC2 methylates histones and DNA; Formation of the beta-catenin:TCF transactivating complex; DNA methylation; Amyloid fiber formation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RNA Polymerase I Chain Elongation; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Condensation of Prophase Chromosomes; Senescence-Associated Secretory Phenotype (SASP); B-WICH complex positively regulates rRNA expression; Oxidative Stress Induced Senescence; RNA Polymerase I Promoter Opening,54,High,1
P62244,40S ribosomal protein S15a OS=Homo sapiens OX=9606 GN=RPS15A PE=1 SV=2,0,75.501,59,7,268,7,130,14.8,10.13,127197,2.03,7,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;mitochondrion;ribosome,protein binding;RNA binding;structural molecule activity,Pf00410,6210,ENSG00000134419.15,RPS15A,16,Ribosome,Cytoplasmic Ribosomal Proteins,"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane",38,High,1
P49354,Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha OS=Homo sapiens OX=9606 GN=FNTA PE=1 SV=1,0,75.459,44,12,106,12,379,44.4,5.08,48111,,12,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;protein binding,Pf01239,2339,ENSG00000168522.12,FNTA,8,Terpenoid backbone biosynthesis,,"Signaling by GPCR; Apoptotic cleavage of cellular proteins; Inactivation, recovery and regulation of the phototransduction cascade",10,High,1
Q7Z3Y8,"Keratin, type I cytoskeletal 27 OS=Homo sapiens OX=9606 GN=KRT27 PE=1 SV=2",0,75.353,10,8,485,1,459,49.8,5.05,257839,3.97,8,1,cell death,cytoplasm;cytosol,structural molecule activity,Pf00038,342574,ENSG00000171446.6,KRT27,17,,,Formation of the cornified envelope,3,High,1
Q3MIX3,Uncharacterized aarF domain-containing protein kinase 5 OS=Homo sapiens OX=9606 GN=ADCK5 PE=1 SV=3,0,75.341,25,10,51,10,580,65.8,8.87,23416,8.38,9,2,metabolic process,,catalytic activity;protein binding,Pf03109,203054,ENSG00000173137.11,ADCK5,8,,,,0,High,1
Q8NE62,"Choline dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=CHDH PE=1 SV=2",0,75.338,27,12,76,12,594,65.3,8.28,30756,0,12,1,metabolic process,membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding,"Pf00732, Pf05199, Pf05834",55349,ENSG00000016391.10,CHDH,3,"Metabolic pathways; Glycine, serine and threonine metabolism",One carbon metabolism and related pathways,Choline catabolism,6,High,1
P32969,60S ribosomal protein L9 OS=Homo sapiens OX=9606 GN=RPL9 PE=1 SV=1,0,75.297,45,7,152,7,192,21.9,9.95,76234,13.04,6,1,cell organization and biogenesis;metabolic process;transport,cytosol;membrane;nucleus;ribosome,protein binding;RNA binding;structural molecule activity,Pf00347,6133,ENSG00000163682.15,RPL9,4,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
P27635,60S ribosomal protein L10 OS=Homo sapiens OX=9606 GN=RPL10 PE=1 SV=4,0,75.082,26,9,250,9,214,24.6,10.08,118277,,9,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytosol;endoplasmic reticulum;membrane;nucleus;ribosome,protein binding;RNA binding;structural molecule activity;translation regulator activity,Pf00252,6134,,RPL10,X,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
P22897,Macrophage mannose receptor 1 OS=Homo sapiens OX=9606 GN=MRC1 PE=1 SV=1,0,75.047,12,15,42,15,1456,165.9,6.54,17307,,15,,regulation of biological process;response to stimulus;transport,cell surface;endosome;membrane,protein binding;receptor activity;signal transducer activity,"Pf00040, Pf00059, Pf00652",4360,ENSG00000260314.2,MRC1,10,Tuberculosis; Phagosome,,Cross-presentation of soluble exogenous antigens (endosomes),7,High,1
O60936,Nucleolar protein 3 OS=Homo sapiens OX=9606 GN=NOL3 PE=1 SV=2,0,74.981,49,7,168,7,208,22.6,4.18,77654,0,7,1,cell death;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;membrane;mitochondrion;nucleus,enzyme regulator activity;metal ion binding;protein binding;RNA binding,Pf00619,8996,ENSG00000140939.14,NOL3,16,,,,0,High,1
Q5QJ74,Tubulin-specific chaperone cofactor E-like protein OS=Homo sapiens OX=9606 GN=TBCEL PE=1 SV=2,0,74.9,42,13,45,13,424,48.2,5.38,18912,0,13,1,,cytoplasm;cytoskeleton,protein binding,"Pf12799, Pf14560, Pf14580",219899,ENSG00000154114.12,TBCEL,11,,,,0,High,1
Q8IY17,Neuropathy target esterase OS=Homo sapiens OX=9606 GN=PNPLA6 PE=1 SV=3,0,74.899,14,13,68,13,1375,150.9,7.74,30335,,13,,,,,,,,,,,,,0,High,1
Q14151,Scaffold attachment factor B2 OS=Homo sapiens OX=9606 GN=SAFB2 PE=1 SV=1,0,74.84,17,12,44,6,953,107.4,6.16,18621,4.45,11,1,cell differentiation;metabolic process;regulation of biological process,cytoplasm;nucleus,DNA binding;protein binding;RNA binding,"Pf00076, Pf02037, Pf13893, Pf14259",9667,ENSG00000130254.11,SAFB2,19,,,,0,High,1
P06702,Protein S100-A9 OS=Homo sapiens OX=9606 GN=S100A9 PE=1 SV=1,0,74.807,48,7,214,7,114,13.2,6.13,106295,,7,,cell communication;cell death;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen,antioxidant activity;catalytic activity;metal ion binding;protein binding;signal transducer activity,"Pf00036, Pf01023, Pf13499, Pf13833",6280,ENSG00000163220.10,S100A9,1,,IL1 and megakaryocytes in obesity,Neutrophil degranulation; Metal sequestration by antimicrobial proteins; Regulation of TLR by endogenous ligand,8,High,1
P08621,U1 small nuclear ribonucleoprotein 70 kDa OS=Homo sapiens OX=9606 GN=SNRNP70 PE=1 SV=2,0,74.795,25,9,77,9,437,51.5,9.94,38179,,9,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus;spliceosomal complex,protein binding;RNA binding,"Pf00076, Pf12220, Pf13893, Pf14259",6625,ENSG00000104852.14,SNRNP70,19,Spliceosome,mRNA Processing,mRNA Splicing - Major Pathway,6,High,1
P19838,Nuclear factor NF-kappa-B p105 subunit OS=Homo sapiens OX=9606 GN=NFKB1 PE=1 SV=2,0,74.714,17,13,70,13,968,105.3,5.4,29539,0,13,1,cell death;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;mitochondrion;nucleus;organelle lumen,DNA binding;protein binding,"Pf00023, Pf00531, Pf00554, Pf12796, Pf13637, Pf13857",4790,ENSG00000109320.11,NFKB1,4,HIF-1 signaling pathway; Acute myeloid leukemia; Cytosolic DNA-sensing pathway; Ras signaling pathway; PI3K-Akt signaling pathway; NOD-like receptor signaling pathway; Neurotrophin signaling pathway; HTLV-I infection; Toll-like receptor signaling pathway; Insulin resistance; Amoebiasis; Chronic myeloid leukemia; AGE-RAGE signaling pathway in diabetic complications; Sphingolipid signaling pathway; cAMP signaling pathway; Chagas disease (American trypanosomiasis); Pancreatic cancer; Pathways in cancer; Transcriptional misregulation in cancer; RIG-I-like receptor signaling pathway; Osteoclast differentiation; Leishmaniasis; Apoptosis; Herpes simplex infection; Longevity regulating pathway; T cell receptor signaling pathway; Epstein-Barr virus infection; Pertussis; Measles; Legionellosis; Th1 and Th2 cell differentiation; MicroRNAs in cancer; NF-kappa B signaling pathway; Non-alcoholic fatty liver disease (NAFLD); Chemokine signaling pathway; MAPK signaling pathway; Shigellosis; B cell receptor signaling pathway; Adipocytokine signaling pathway; Antifolate resistance; Influenza A; Prolactin signaling pathway; Epithelial cell signaling in Helicobacter pylori infection; Hepatitis B; Hepatitis C; TNF signaling pathway; Small cell lung cancer; Inflammatory bowel disease (IBD); Cocaine addiction; Viral carcinogenesis; Salmonella infection; Toxoplasmosis; Tuberculosis; Prostate cancer,"Osteopontin Signaling; Regulation of toll-like receptor signaling pathway; Selenium Micronutrient Network; Vitamin B12 Metabolism; MicroRNAs in cardiomyocyte hypertrophy; TFs Regulate miRNAs related to cardiac hypertrophy; Folate Metabolism; IL-1 signaling pathway; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; Leptin signaling pathway; TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway; Prolactin Signaling Pathway; Neural Crest Differentiation; IL17 signaling pathway; B Cell Receptor Signaling Pathway; TNF alpha Signaling Pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis; Apoptosis; T-Cell Receptor and Co-stimulatory Signaling; Aryl Hydrocarbon Receptor; EBV LMP1 signaling; Cardiac Hypertrophic Response; Selenium Metabolism and Selenoproteins; Apoptosis-related network due to altered Notch3 in ovarian cancer; IL1 and megakaryocytes in obesity; Myometrial Relaxation and Contraction Pathways; Melatonin metabolism and effects; Rac1/Pak1/p38/MMP-2 pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Photodynamic therapy-induced NF-kB survival signaling; NAD metabolism, sirtuins and aging; Hepatitis C and Hepatocellular Carcinoma; MAPK Signaling Pathway; Apoptosis Modulation by HSP70; MAPK  and NFkB Signalling Pathways Inhibited by Yersinia YopJ; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TLR4 Signaling and Tolerance; Toll-like Receptor Signaling; T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection; RIG-I-like Receptor Signaling; Simplified Depiction of MYD88 Distinct Input-Output Pathway; ATM Signaling Network in Development and Disease; VEGFA-VEGFR2 Signaling Pathway; Chemokine signaling pathway; Oxidative Damage; IL-4 Signaling Pathway; Oxidative Stress; TGF-beta Receptor Signaling; Notch Signaling Pathway; T-Cell antigen Receptor (TCR)  Signaling Pathway; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways; Estrogen signaling pathway; Toll-like receptor signaling pathway",CLEC7A/inflammasome pathway; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); Regulated proteolysis of p75NTR; Downstream TCR signaling; Transcriptional regulation of white adipocyte differentiation; TRAF6 mediated NF-kB activation; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; MAP3K8 (TPL2)-dependent MAPK1/3 activation; RIP-mediated NFkB activation via ZBP1; Activated TLR4 signalling; Neutrophil degranulation; Interleukin-1 processing; PKMTs methylate histone lysines; FCERI mediated NF-kB activation; CD209 (DC-SIGN) signaling; Activation of NF-kappaB in B cells; DEx/H-box helicases activate type I IFN and inflammatory cytokines production ; NF-kB is activated and signals survival; Signalling by NGF; IkBA variant leads to EDA-ID; Senescence-Associated Secretory Phenotype (SASP),178,High,1
Q86SX6,"Glutaredoxin-related protein 5, mitochondrial OS=Homo sapiens OX=9606 GN=GLRX5 PE=1 SV=2",0,74.701,29,7,101,7,157,16.6,6.79,54422,,7,,cellular homeostasis;metabolic process;regulation of biological process,mitochondrion;nucleus;organelle lumen,catalytic activity;metal ion binding;protein binding,Pf00462,51218,ENSG00000182512.4,GLRX5,14,,,Mitochondrial iron-sulfur cluster biogenesis,2,High,1
P19784,Casein kinase II subunit alpha' OS=Homo sapiens OX=9606 GN=CSNK2A2 PE=1 SV=1,0,74.687,45,11,82,10,350,41.2,8.56,26731,,11,,cell communication;cell death;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf01636, Pf07714",1459,ENSG00000070770.8,CSNK2A2,16,Measles; Ribosome biogenesis in eukaryotes; Wnt signaling pathway; Tight junction; Herpes simplex infection; Adherens junction; NF-kappa B signaling pathway; Epstein-Barr virus infection,Allograft Rejection,WNT mediated activation of DVL; Condensation of Prometaphase Chromosomes; Regulation of PTEN stability and activity; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Signal transduction by L1; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Synthesis of PC; Receptor Mediated Mitophagy; Regulation of TP53 Activity through Phosphorylation,45,High,1
O15126,Secretory carrier-associated membrane protein 1 OS=Homo sapiens OX=9606 GN=SCAMP1 PE=1 SV=2,0,74.598,36,7,75,7,338,37.9,7.42,30774,,7,,transport,endosome;Golgi;membrane,protein binding,Pf04144,9522,ENSG00000085365.17,SCAMP1,5,,,Neutrophil degranulation,3,High,1
Q96T66,Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 OS=Homo sapiens OX=9606 GN=NMNAT3 PE=1 SV=2,0,74.582,47,9,85,9,252,28.3,9.22,39926,,9,,metabolic process;response to stimulus,mitochondrion;organelle lumen,catalytic activity;nucleotide binding,Pf01467,349565,ENSG00000163864.15,NMNAT3,3,Nicotinate and nicotinamide metabolism; Metabolic pathways,NAD+ metabolism,Nicotinate metabolism,7,High,1
P62249,40S ribosomal protein S16 OS=Homo sapiens OX=9606 GN=RPS16 PE=1 SV=2,0,74.482,53,9,374,9,146,16.4,10.21,183519,1.82,9,1,cell organization and biogenesis;metabolic process;transport,cytosol;membrane;ribosome,protein binding;RNA binding;structural molecule activity,Pf00380,6217,ENSG00000105193.8,RPS16,19,Ribosome,Cytoplasmic Ribosomal Proteins,"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane",38,High,1
O00186,Syntaxin-binding protein 3 OS=Homo sapiens OX=9606 GN=STXBP3 PE=1 SV=2,0,74.462,21,12,96,12,592,67.7,7.8,46469,,12,,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane,protein binding,Pf00995,6814,ENSG00000116266.10,STXBP3,1,,Insulin Signaling,Translocation of GLUT4 to the plasma membrane; Disinhibition of SNARE formation,8,High,1
P09001,"39S ribosomal protein L3, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL3 PE=1 SV=1",0,74.425,33,11,124,11,348,38.6,9.48,48694,0,11,1,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,catalytic activity;RNA binding;structural molecule activity,Pf00297,11222,ENSG00000114686.8,MRPL3,3,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
O14828,Secretory carrier-associated membrane protein 3 OS=Homo sapiens OX=9606 GN=SCAMP3 PE=1 SV=3,0,74.245,41,9,80,9,347,38.3,7.64,36257,3.06,9,1,transport,membrane,protein binding,Pf04144,10067,ENSG00000116521.10; ENSG00000263290.5,SCAMP3,1; CHR_HSCHR1_2_CTG31,,,,0,High,1
Q8IVS2,"Malonyl-CoA-acyl carrier protein transacylase, mitochondrial OS=Homo sapiens OX=9606 GN=MCAT PE=1 SV=2",0,74.223,41,12,124,12,390,42.9,8.72,55254,3.38,12,2,metabolic process,mitochondrion;organelle lumen,catalytic activity;RNA binding,Pf00698,27349,ENSG00000100294.12,MCAT,22,Metabolic pathways; Fatty acid metabolism; Fatty acid biosynthesis,,Mitochondrial Fatty Acid Beta-Oxidation,7,High,1
Q9UHL4,Dipeptidyl peptidase 2 OS=Homo sapiens OX=9606 GN=DPP7 PE=1 SV=3,0,74.024,34,13,68,13,492,54.3,6.32,30843,,13,,metabolic process;transport,cytosol;extracellular;Golgi;organelle lumen;vacuole,catalytic activity,"Pf00561, Pf05577",29952,ENSG00000176978.13,DPP7,9,,,Neutrophil degranulation,3,High,1
Q15631,Translin OS=Homo sapiens OX=9606 GN=TSN PE=1 SV=1,0,73.975,41,10,96,10,228,26.2,6.44,54353,,10,,metabolic process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;DNA binding;protein binding;RNA binding,Pf01997,7247,ENSG00000211460.11,TSN,2,,,Small interfering RNA (siRNA) biogenesis,3,High,1
Q8TAQ2,SWI/SNF complex subunit SMARCC2 OS=Homo sapiens OX=9606 GN=SMARCC2 PE=1 SV=1,0,73.959,17,15,46,15,1214,132.8,5.69,16844,,15,,cell organization and biogenesis;metabolic process;regulation of biological process,nucleus,DNA binding;protein binding,Pf04433,6601,ENSG00000139613.11,SMARCC2,12,,,RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines,8,High,1
Q14677-3,Isoform 3 of Clathrin interactor 1 OS=Homo sapiens OX=9606 GN=CLINT1,0,73.938,24,13,95,13,643,70.3,6.58,42327,6.79,12,1,cell organization and biogenesis;transport,cytosol;Golgi;membrane,protein binding,"Pf01417, Pf07651",9685,ENSG00000113282.13,CLINT1,5,,,,0,High,1
Q8IXB1,DnaJ homolog subfamily C member 10 OS=Homo sapiens OX=9606 GN=DNAJC10 PE=1 SV=2,0,73.938,23,14,76,14,793,91,7.18,30888,,14,,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;membrane;organelle lumen,catalytic activity;enzyme regulator activity;protein binding,"Pf00085, Pf00226, Pf13098, Pf13728, Pf13848, Pf13905",54431,ENSG00000077232.17,DNAJC10,2,Protein processing in endoplasmic reticulum,,,1,High,1
P61088,Ubiquitin-conjugating enzyme E2 N OS=Homo sapiens OX=9606 GN=UBE2N PE=1 SV=1,0,73.929,52,8,252,8,152,17.1,6.57,127598,,8,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00179, Pf05743, Pf05773",7334,ENSG00000177889.9,UBE2N,12,Ubiquitin mediated proteolysis,IL-1 signaling pathway; Interleukin-1 Induced Activation of NF-kappa-B; Simplified Depiction of MYD88 Distinct Input-Output Pathway,"IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; ISG15 antiviral mechanism; Downstream TCR signaling; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment ; Nonhomologous End-Joining (NHEJ); TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Antigen processing: Ubiquitination & Proteasome degradation; Activated TLR4 signalling; Interleukin-1 family signaling; Formation of Incision Complex in GG-NER; IRAK1 recruits IKK complex; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling; activated TAK1 mediates p38 MAPK activation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; G2/M DNA damage checkpoint; IKK complex recruitment mediated by RIP1; FCERI mediated NF-kB activation; E3 ubiquitin ligases ubiquitinate target proteins; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; Processing of DNA double-strand break ends; CLEC7A (Dectin-1) signaling",69,High,1
P51570,Galactokinase OS=Homo sapiens OX=9606 GN=GALK1 PE=1 SV=1,0,73.879,32,10,92,10,392,42.2,6.46,46050,0,10,1,metabolic process,cytoplasm;cytosol;membrane,catalytic activity;nucleotide binding,"Pf08544, Pf10509",2584,ENSG00000108479.11,GALK1,17,Amino sugar and nucleotide sugar metabolism; Galactose metabolism; Metabolic pathways,,Galactose catabolism; Defective GALK1 can cause Galactosemia II (GALCT2),10,High,1
Q86VD7,Mitochondrial coenzyme A transporter SLC25A42 OS=Homo sapiens OX=9606 GN=SLC25A42 PE=1 SV=2,0,73.839,30,8,98,8,318,35.4,10.07,47357,,8,,transport,membrane;mitochondrion;nucleus,catalytic activity;transporter activity,Pf00153,284439,ENSG00000181035.13,SLC25A42,19,,,,0,High,1
P27169,Serum paraoxonase/arylesterase 1 OS=Homo sapiens OX=9606 GN=PON1 PE=1 SV=3,0,73.835,40,8,67,7,355,39.7,5.22,27536,0,8,1,metabolic process;regulation of biological process;response to stimulus,extracellular,antioxidant activity;catalytic activity;metal ion binding;protein binding,"Pf01731, Pf03088, Pf08450",5444,ENSG00000005421.8,PON1,7,Metabolic pathways,"Phase I biotransformations, non P450",Synthesis of 5-eicosatetraenoic acids,7,High,1
Q9HD33,"39S ribosomal protein L47, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL47 PE=1 SV=2",0,73.83,32,10,137,10,250,29.4,10.37,74550,0,10,1,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,structural molecule activity,Pf06984,57129,ENSG00000136522.13,MRPL47,3,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
Q8N2F6,Armadillo repeat-containing protein 10 OS=Homo sapiens OX=9606 GN=ARMC10 PE=1 SV=1,0,73.814,33,8,110,8,343,37.5,6.61,48517,,8,,regulation of biological process,endoplasmic reticulum;membrane;mitochondrion,protein binding,Pf04826,83787,ENSG00000170632.13,ARMC10,7,,,,0,High,1
Q14344,Guanine nucleotide-binding protein subunit alpha-13 OS=Homo sapiens OX=9606 GN=GNA13 PE=1 SV=2,0,73.709,37,12,77,10,377,44,8,31568,,12,,cell differentiation;cellular component movement;cellular homeostasis;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,"Pf00025, Pf00503",10672,ENSG00000120063.9,GNA13,17,Long-term depression; Phospholipase D signaling pathway; Regulation of actin cytoskeleton; cGMP-PKG signaling pathway; Platelet activation; Sphingolipid signaling pathway; Pathways in cancer; Vascular smooth muscle contraction,Human Thyroid Stimulating Hormone (TSH) signaling pathway; G Protein Signaling Pathways; Regulation of Actin Cytoskeleton; G13 Signaling Pathway,Thrombin signalling through proteinase activated receptors (PARs); G alpha (12/13) signalling events; NRAGE signals death through JNK; Thromboxane signalling through TP receptor; Rho GTPase cycle; Signalling by NGF,28,High,1
P36551,"Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial OS=Homo sapiens OX=9606 GN=CPOX PE=1 SV=3",0,73.646,24,9,108,9,454,50.1,8.25,51037,0,9,1,metabolic process;response to stimulus,cytosol;membrane;mitochondrion,catalytic activity;protein binding;structural molecule activity,Pf01218,1371,ENSG00000080819.6,CPOX,3,Porphyrin and chlorophyll metabolism; Metabolic pathways,Heme Biosynthesis,Heme biosynthesis,6,High,1
P57105,Synaptojanin-2-binding protein OS=Homo sapiens OX=9606 GN=SYNJ2BP PE=1 SV=2,0,73.633,66,9,165,9,145,15.9,6.3,72856,,9,,regulation of biological process,membrane;mitochondrion,protein binding,"Pf00595, Pf13180",55333,ENSG00000213463.4,SYNJ2BP,14,,,,0,High,1
Q86Y82,Syntaxin-12 OS=Homo sapiens OX=9606 GN=STX12 PE=1 SV=1,0,73.547,36,8,72,8,276,31.6,5.59,33880,,8,,cell organization and biogenesis;regulation of biological process;transport,endosome;Golgi;membrane,protein binding,"Pf00804, Pf05739, Pf14523",23673,ENSG00000117758.13,STX12,1,Phagosome,,,1,High,1
Q9BQG0,Myb-binding protein 1A OS=Homo sapiens OX=9606 GN=MYBBP1A PE=1 SV=2,0,73.524,16,17,59,17,1328,148.8,9.28,21188,,17,,cell communication;cell differentiation;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;membrane;nucleus,catalytic activity;DNA binding;protein binding;RNA binding,"Pf04931, Pf05793, Pf11593, Pf12815",10514,ENSG00000132382.14,MYBBP1A,17,,Energy Metabolism,B-WICH complex positively regulates rRNA expression,5,High,1
Q86X76,Deaminated glutathione amidase OS=Homo sapiens OX=9606 GN=NIT1 PE=1 SV=2,0,73.459,24,6,94,6,327,35.9,7.74,52348,,6,,metabolic process,cytoplasm;mitochondrion;nucleus,catalytic activity,Pf00795,4817,ENSG00000158793.13,NIT1,1,,,,0,High,1
Q6PI78,Transmembrane protein 65 OS=Homo sapiens OX=9606 GN=TMEM65 PE=1 SV=2,0,73.425,29,9,304,9,240,25.5,8.6,152055,0,9,1,,membrane;mitochondrion,,Pf10507,157378,ENSG00000164983.7,TMEM65,8,,,,0,High,1
Q9UNF1,Melanoma-associated antigen D2 OS=Homo sapiens OX=9606 GN=MAGED2 PE=1 SV=2,0,73.405,38,15,69,13,606,64.9,9.32,29841,,15,,transport,cytosol;extracellular;membrane;nucleus;organelle lumen,protein binding,Pf01454,10916,ENSG00000102316.16,MAGED2,X,,,Platelet degranulation,4,High,1
P33316,"Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=DUT PE=1 SV=4",0,73.388,37,7,99,7,252,26.5,9.36,46278,,7,,metabolic process,mitochondrion;nucleus,catalytic activity;metal ion binding;protein binding;RNA binding,Pf00692,1854,ENSG00000128951.13,DUT,15,Pyrimidine metabolism; Metabolic pathways,,,2,High,1
O14979-2,Isoform 2 of Heterogeneous nuclear ribonucleoprotein D-like OS=Homo sapiens OX=9606 GN=HNRNPDL,0,73.37,27,7,137,1,301,33.6,7.31,69356,11.99,6,2,metabolic process;regulation of biological process;response to stimulus,cytosol,DNA binding;protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",9987,ENSG00000152795.17,HNRNPDL; HNRPDL,4,,,,0,High,1
P08572,Collagen alpha-2(IV) chain OS=Homo sapiens OX=9606 GN=COL4A2 PE=1 SV=4,0,73.327,5,6,122,6,1712,167.4,8.66,64344,2.18,6,1,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,extracellular;organelle lumen,protein binding;structural molecule activity,"Pf01391, Pf01413",1284,ENSG00000134871.17,COL4A2,13,AGE-RAGE signaling pathway in diabetic complications; Amoebiasis; Small cell lung cancer; Pathways in cancer; ECM-receptor interaction; PI3K-Akt signaling pathway; Focal adhesion; Protein digestion and absorption,miRNA targets in ECM and membrane receptors; Focal Adhesion; Hepatitis C and Hepatocellular Carcinoma; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,ECM proteoglycans; Collagen degradation; Integrin cell surface interactions; Laminin interactions; Collagen chain trimerization; Crosslinking of collagen fibrils; Anchoring fibril formation; Signaling by PDGF; NCAM1 interactions; Scavenging by Class A Receptors; Non-integrin membrane-ECM interactions,35,High,1
Q9P260,RAB11-binding protein RELCH OS=Homo sapiens OX=9606 GN=RELCH PE=1 SV=2,0,73.221,14,13,52,13,1216,134.5,5.45,19709,,13,,,,protein binding,,57614,ENSG00000134444.13,KIAA1468,18,,,,0,High,1
Q9HB40,Retinoid-inducible serine carboxypeptidase OS=Homo sapiens OX=9606 GN=SCPEP1 PE=1 SV=1,0,73.157,25,10,44,10,452,50.8,5.81,17953,1.95,10,1,metabolic process,cytosol;extracellular,catalytic activity,Pf00450,59342,ENSG00000121064.12,SCPEP1,17,,,,0,High,1
A0M8Q6,Immunoglobulin lambda constant 7 OS=Homo sapiens OX=9606 GN=IGLC7 PE=1 SV=3,0,73.133,46,8,531,1,106,11.2,8.29,250071,0,8,1,cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity;protein binding,"Pf07654, Pf08205, Pf13927",28834,,IGLC7,22,,,FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis,26,High,1
Q9BYV6,Tripartite motif-containing protein 55 OS=Homo sapiens OX=9606 GN=TRIM55 PE=1 SV=2,0,73.078,20,9,95,7,548,60.4,4.77,34460,84.9,5,5,regulation of biological process;response to stimulus,cytoplasm;nucleus,metal ion binding;protein binding;signal transducer activity,"Pf00097, Pf00643, Pf13445, Pf13639, Pf13920, Pf13923, Pf14634, Pf14835, Pf15227",84675,ENSG00000147573.16,TRIM55,8,,,,0,High,1
O15211,Ral guanine nucleotide dissociation stimulator-like 2 OS=Homo sapiens OX=9606 GN=RGL2 PE=1 SV=1,0,73.046,29,13,50,13,777,83.5,6.18,20284,2.41,12,1,regulation of biological process;response to stimulus,,protein binding,"Pf00617, Pf00618, Pf00788",5863,ENSG00000206282.11; ENSG00000237825.9; ENSG00000237441.9; ENSG00000228736.9; ENSG00000224841.9,RGL2,6; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_COX_CTG1,Ras signaling pathway,,,1,High,1
P78347,General transcription factor II-I OS=Homo sapiens OX=9606 GN=GTF2I PE=1 SV=2,0,73.007,17,13,63,13,998,112.3,6.39,25058,,13,,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;membrane;nucleus,DNA binding;protein binding,Pf02946,2969,ENSG00000263001.5,GTF2I,7,Herpes simplex infection; cGMP-PKG signaling pathway; Basal transcription factors,B Cell Receptor Signaling Pathway,,4,High,1
Q9Y3B8,"Oligoribonuclease, mitochondrial OS=Homo sapiens OX=9606 GN=REXO2 PE=1 SV=3",0,73.006,38,8,129,1,237,26.8,6.87,58188,5.71,7,3,metabolic process,cytoplasm;mitochondrion;nucleus;organelle lumen,catalytic activity,Pf00929,25996,ENSG00000076043.9,REXO2,11,Ribosome biogenesis in eukaryotes,,,1,High,1
P55058,Phospholipid transfer protein OS=Homo sapiens OX=9606 GN=PLTP PE=1 SV=1,0,72.95,30,11,41,11,493,54.7,7.01,18372,,11,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport,extracellular,transporter activity,"Pf01273, Pf02886",5360,ENSG00000100979.14,PLTP,20,PPAR signaling pathway,PPAR Alpha Pathway; PPAR signaling pathway; Statin Pathway,HDL remodeling,8,High,1
Q13404,Ubiquitin-conjugating enzyme E2 variant 1 OS=Homo sapiens OX=9606 GN=UBE2V1 PE=1 SV=2,0,72.919,56,8,260,2,147,16.5,7.93,117666,,8,,cell differentiation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,Pf00179,7335; 387522,ENSG00000244687.11,UBE2V1; TMEM189-UBE2V1,20,,IL-1 signaling pathway; Interleukin-1 Induced Activation of NF-kappa-B; Simplified Depiction of MYD88 Distinct Input-Output Pathway,"IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Downstream TCR signaling; NOD1/2 Signaling Pathway; IKK complex recruitment mediated by RIP1; TICAM1, RIP1-mediated IKK complex recruitment ; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Activated TLR4 signalling; Interleukin-1 family signaling; IRAK1 recruits IKK complex; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling; activated TAK1 mediates p38 MAPK activation; CLEC7A (Dectin-1) signaling",46,High,1
Q9Y6E0-2,Isoform A of Serine/threonine-protein kinase 24 OS=Homo sapiens OX=9606 GN=STK24,0,72.886,30,12,94,4,431,47.9,5.43,39555,20.92,11,2,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;Golgi;membrane;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf06840, Pf07714",8428,ENSG00000102572.14,STK24,13,,,,0,High,1
Q96HY6,DDRGK domain-containing protein 1 OS=Homo sapiens OX=9606 GN=DDRGK1 PE=1 SV=2,0,72.874,41,7,66,7,314,35.6,5.12,32730,0,7,1,regulation of biological process;response to stimulus,cytoplasm;endoplasmic reticulum;membrane,protein binding,Pf09756,65992,ENSG00000198171.12,DDRGK1,20,,,,0,High,1
Q9UBX5,Fibulin-5 OS=Homo sapiens OX=9606 GN=FBLN5 PE=1 SV=1,0,72.868,21,8,156,8,448,50.1,4.73,70884,,8,,cell organization and biogenesis;regulation of biological process;transport,extracellular,metal ion binding;protein binding,"Pf07645, Pf12662, Pf12947, Pf14670",10516,ENSG00000140092.14,FBLN5,14,,,Molecules associated with elastic fibres,3,High,1
Q7Z4H3,HD domain-containing protein 2 OS=Homo sapiens OX=9606 GN=HDDC2 PE=1 SV=1,0,72.865,42,8,90,8,204,23.4,5.49,42743,,8,,,mitochondrion,protein binding,"Pf01966, Pf13023",51020,ENSG00000111906.17,HDDC2,6,,,,0,High,1
Q9UNE7,E3 ubiquitin-protein ligase CHIP OS=Homo sapiens OX=9606 GN=STUB1 PE=1 SV=2,0,72.851,33,11,72,11,303,34.8,5.87,32092,,11,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;nucleus,catalytic activity;protein binding,"Pf00515, Pf04564, Pf07719, Pf12895, Pf13414, Pf13424, Pf13432, Pf14559",10273,ENSG00000103266.10,STUB1,16,Protein processing in endoplasmic reticulum; Ubiquitin mediated proteolysis,Androgen receptor signaling pathway; Parkin-Ubiquitin Proteasomal System pathway,Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Downregulation of ERBB2 signaling; Downregulation of TGF-beta receptor signaling; Antigen processing: Ubiquitination & Proteasome degradation,25,High,1
P35658,Nuclear pore complex protein Nup214 OS=Homo sapiens OX=9606 GN=NUP214 PE=1 SV=2,0,72.84,10,14,44,14,2090,213.5,7.47,17456,,14,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;nucleus,protein binding;structural molecule activity;transporter activity,,8021,ENSG00000126883.16,NUP214,9,RNA transport; Epstein-Barr virus infection,TGF-beta Signaling Pathway,Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; HuR (ELAVL1) binds and stabilizes mRNA; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins,68,High,1
P35637,RNA-binding protein FUS OS=Homo sapiens OX=9606 GN=FUS PE=1 SV=1,0,72.833,20,8,76,6,526,53.4,9.36,38316,,8,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,DNA binding;metal ion binding;protein binding;RNA binding,"Pf00076, Pf00641, Pf13893, Pf14259",2521,ENSG00000089280.18,FUS,16,Transcriptional misregulation in cancer,mRNA Processing,mRNA Splicing - Major Pathway,6,High,1
Q15738,"Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating OS=Homo sapiens OX=9606 GN=NSDHL PE=1 SV=2",0,72.823,28,8,52,8,373,41.9,8.06,27006,,8,,metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;membrane,catalytic activity,"Pf00106, Pf01073, Pf01370, Pf02719, Pf04321, Pf05368, Pf07993, Pf13460",50814,ENSG00000147383.10,NSDHL,X,Steroid biosynthesis; Metabolic pathways,Cholesterol Biosynthesis,Cholesterol biosynthesis,7,High,1
Q3SXM5,Inactive hydroxysteroid dehydrogenase-like protein 1 OS=Homo sapiens OX=9606 GN=HSDL1 PE=1 SV=3,0,72.781,28,9,148,9,330,37,8.72,81769,1.68,9,2,,mitochondrion,,"Pf00106, Pf13460, Pf13561",83693,ENSG00000103160.11,HSDL1,16,,,,0,High,1
Q14558,Phosphoribosyl pyrophosphate synthase-associated protein 1 OS=Homo sapiens OX=9606 GN=PRPSAP1 PE=1 SV=2,0,72.716,40,10,59,9,356,39.4,7.2,23039,,10,,metabolic process;regulation of biological process,,catalytic activity;enzyme regulator activity;metal ion binding;protein binding,"Pf13793, Pf14572",5635,,PRPSAP1,17,,,,0,High,1
P07738,Bisphosphoglycerate mutase OS=Homo sapiens OX=9606 GN=BPGM PE=1 SV=2,0,72.663,45,10,119,10,259,30,6.54,52662,0,10,1,metabolic process;regulation of biological process,cytosol,catalytic activity,Pf00300,669,ENSG00000172331.11,BPGM,7,"Glycine, serine and threonine metabolism; Metabolic pathways; Glycolysis / Gluconeogenesis",,Glycolysis,7,High,1
Q9UID3,Vacuolar protein sorting-associated protein 51 homolog OS=Homo sapiens OX=9606 GN=VPS51 PE=1 SV=2,0,72.635,19,12,65,12,782,86,6.47,32390,0,12,1,cell organization and biogenesis;metabolic process;transport,cytosol;endosome;Golgi;membrane,protein binding,"Pf04124, Pf06148, Pf08700, Pf15469",738,ENSG00000149823.8,VPS51,11,,,Retrograde transport at the Trans-Golgi-Network,4,High,1
Q9BXP5,Serrate RNA effector molecule homolog OS=Homo sapiens OX=9606 GN=SRRT PE=1 SV=1,0,72.594,15,13,85,13,876,100.6,5.96,34015,0,13,1,cell proliferation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,DNA binding;protein binding;RNA binding,"Pf04959, Pf12066",51593,ENSG00000087087.18,SRRT,7,,,RNA polymerase II transcribes snRNA genes; mRNA Splicing - Major Pathway,7,High,1
Q53H82,Endoribonuclease LACTB2 OS=Homo sapiens OX=9606 GN=LACTB2 PE=1 SV=2,0,72.591,32,8,111,8,288,32.8,6.8,54159,,8,,metabolic process,mitochondrion;organelle lumen,catalytic activity;metal ion binding;protein binding;RNA binding,Pf00753,51110,ENSG00000147592.8,LACTB2,8,,,,0,High,1
O95394,Phosphoacetylglucosamine mutase OS=Homo sapiens OX=9606 GN=PGM3 PE=1 SV=1,0,72.555,29,11,66,11,542,59.8,6.25,31497,0,11,1,metabolic process,cytosol,catalytic activity;metal ion binding,"Pf00408, Pf02878, Pf02879, Pf02880",5238,ENSG00000013375.15,PGM3,6,Amino sugar and nucleotide sugar metabolism; Metabolic pathways,Glucuronidation,Synthesis of UDP-N-acetyl-glucosamine,9,High,1
Q5TEU4,"Arginine-hydroxylase NDUFAF5, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFAF5 PE=1 SV=1",0,72.515,33,10,70,10,345,38.9,6.57,31646,0,9,1,cell organization and biogenesis;metabolic process,membrane;mitochondrion,catalytic activity;protein binding,"Pf01209, Pf01728, Pf08241, Pf08242, Pf12847, Pf13489, Pf13649, Pf13659, Pf13847",79133,ENSG00000101247.17,NDUFAF5,20,,,Complex I biogenesis,5,High,1
P10643,Complement component C7 OS=Homo sapiens OX=9606 GN=C7 PE=1 SV=2,0,72.499,16,10,87,10,843,93.5,6.48,36486,,10,,cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus,extracellular,protein binding,"Pf00084, Pf01823",730,ENSG00000112936.18,C7,5,Systemic lupus erythematosus; Prion diseases; Complement and coagulation cascades,Allograft Rejection; Complement Activation; Complement and Coagulation Cascades,Terminal pathway of complement; Regulation of Complement cascade,11,High,1
P04432,Immunoglobulin kappa variable 1D-39 OS=Homo sapiens OX=9606 GN=IGKV1D-39 PE=3 SV=2,0,72.48,42,8,95,1,117,12.7,8.66,49374,,8,,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity,"Pf00047, Pf07679, Pf07686, Pf13927",28930; 28893,ENSG00000282120.1; ENSG00000251546.1; ENSG00000242371.1,IGKV1-39; IGKV1D-39,2; CHR_HG2290_PATCH,,,FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis,26,High,1
Q9NVA1,Ubiquinol-cytochrome-c reductase complex assembly factor 1 OS=Homo sapiens OX=9606 GN=UQCC1 PE=1 SV=3,0,72.456,33,7,144,7,299,34.6,8.91,56402,38.04,6,2,cell organization and biogenesis;regulation of biological process,membrane;mitochondrion,protein binding,Pf03981,55245,ENSG00000101019.21,UQCC; UQCC1,20,,,,0,High,1
P04424,Argininosuccinate lyase OS=Homo sapiens OX=9606 GN=ASL PE=1 SV=4,0,72.408,28,12,43,12,464,51.6,6.48,19104,0,12,2,metabolic process;response to stimulus,cytoplasm;cytosol,catalytic activity;protein binding,"Pf00206, Pf14698",435,ENSG00000126522.16,ASL,7,"Biosynthesis of amino acids; Metabolic pathways; Arginine biosynthesis; Alanine, aspartate and glutamate metabolism",Alanine and aspartate metabolism; Urea cycle and metabolism of amino groups,Urea cycle,10,High,1
Q9UH65,Switch-associated protein 70 OS=Homo sapiens OX=9606 GN=SWAP70 PE=1 SV=1,0,72.246,30,14,54,14,585,69,5.87,17233,2.23,14,2,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process,cytoplasm;cytoskeleton;membrane;nucleus,DNA binding;metal ion binding;nucleotide binding;protein binding,"Pf00169, Pf15413",23075,ENSG00000133789.14,SWAP70,11,,,,0,High,1
P00734,Prothrombin OS=Homo sapiens OX=9606 GN=F2 PE=1 SV=2,0,72.121,13,7,141,7,622,70,5.9,66118,1.73,7,1,cellular component movement;cellular homeostasis;coagulation;defense response;development;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane;organelle lumen,catalytic activity;metal ion binding;protein binding;receptor activity;signal transducer activity,"Pf00051, Pf00089, Pf00594, Pf09342, Pf09396",2147,ENSG00000180210.14,F2,11,Complement and coagulation cascades; Regulation of actin cytoskeleton; Neuroactive ligand-receptor interaction,Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism; Blood Clotting Cascade; IL1 and megakaryocytes in obesity; Regulation of Actin Cytoskeleton; Complement and Coagulation Cascades,Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Peptide ligand-binding receptors; Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus; Intrinsic Pathway of Fibrin Clot Formation; Removal of aminoterminal propeptides from gamma-carboxylated proteins; Gamma-carboxylation of protein precursors; Thrombin signalling through proteinase activated receptors (PARs); Platelet Aggregation (Plug Formation); Regulation of Complement cascade; Common Pathway of Fibrin Clot Formation; Gastrin-CREB signalling pathway via PKC and MAPK; Cell surface interactions at the vascular wall,38,High,1
Q8TCA0,Leucine-rich repeat-containing protein 20 OS=Homo sapiens OX=9606 GN=LRRC20 PE=1 SV=1,0,72.059,52,9,163,9,184,20.5,6.55,70761,0,9,1,,,protein binding,"Pf12799, Pf13855",55222,ENSG00000172731.13,LRRC20,10,,,,0,High,1
Q9GZZ9,Ubiquitin-like modifier-activating enzyme 5 OS=Homo sapiens OX=9606 GN=UBA5 PE=1 SV=1,0,72.036,28,7,91,7,404,44.8,4.84,34860,,7,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,Pf00899,79876,ENSG00000081307.12,UBA5,3,,,Antigen processing: Ubiquitination & Proteasome degradation,4,High,1
Q9NWV4,CXXC motif containing zinc binding protein OS=Homo sapiens OX=9606 GN=CZIB PE=1 SV=1,0,72.007,65,6,94,6,160,18,5.01,44959,,6,,,,,Pf05907,54987,ENSG00000162384.13,C1orf123,1,,,,0,High,1
Q9Y5M8,Signal recognition particle receptor subunit beta OS=Homo sapiens OX=9606 GN=SRPRB PE=1 SV=3,0,71.975,37,8,108,8,271,29.7,9.04,51811,,8,,regulation of biological process;response to stimulus,cytoplasm;endoplasmic reticulum;membrane,nucleotide binding,"Pf00009, Pf00025, Pf01926, Pf02421, Pf09439",58477,ENSG00000144867.11,SRPRB,3,Protein export,,XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane,7,High,1
Q8WUY1,Protein THEM6 OS=Homo sapiens OX=9606 GN=THEM6 PE=1 SV=2,0,71.933,47,11,81,11,208,23.9,9.55,35276,0,11,1,,extracellular,,Pf13279,51337,ENSG00000130193.7,THEM6,8,,,,0,High,1
P49023-4,Isoform 4 of Paxillin OS=Homo sapiens OX=9606 GN=PXN,0,71.851,31,8,142,1,424,46.6,7.08,66297,2.06,7,2,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cytosol;membrane,metal ion binding;protein binding,"Pf00412, Pf03535",5829,ENSG00000089159.16,PXN,12,,Integrin-mediated Cell Adhesion; Prolactin Signaling Pathway; Oncostatin M Signaling Pathway; Focal Adhesion; Signaling of Hepatocyte Growth Factor Receptor; Rac1/Pak1/p38/MMP-2 pathway; VEGFA-VEGFR2 Signaling Pathway; Chemokine signaling pathway; Regulation of Actin Cytoskeleton,,9,High,1
Q14997,Proteasome activator complex subunit 4 OS=Homo sapiens OX=9606 GN=PSME4 PE=1 SV=2,0,71.818,12,16,53,16,1843,211.2,6.9,18720,,16,,cell differentiation;cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus;proteasome,enzyme regulator activity;protein binding,Pf11919,23198,ENSG00000068878.14,PSME4,2,Proteasome,,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,141,High,1
Q13232,Nucleoside diphosphate kinase 3 OS=Homo sapiens OX=9606 GN=NME3 PE=1 SV=2,0,71.76,51,8,151,8,169,19,7.84,64096,,8,,cell death;metabolic process;regulation of biological process,cytosol;mitochondrion,catalytic activity;metal ion binding;nucleotide binding;protein binding,Pf00334,4832,ENSG00000103024.7,NME3,16,Metabolic pathways; Pyrimidine metabolism; Purine metabolism,,Interconversion of nucleotide di- and triphosphates,6,High,1
Q9BYT8,"Neurolysin, mitochondrial OS=Homo sapiens OX=9606 GN=NLN PE=1 SV=1",0,71.74,22,13,70,12,704,80.6,6.64,27256,0,13,1,metabolic process;regulation of biological process,cytoplasm;extracellular;membrane;mitochondrion,catalytic activity;metal ion binding,Pf01432,57486,ENSG00000123213.22,NLN,5,Renin-angiotensin system,,Peptide ligand-binding receptors,6,High,1
P07902,Galactose-1-phosphate uridylyltransferase OS=Homo sapiens OX=9606 GN=GALT PE=1 SV=3,0,71.71,39,11,59,11,379,43.3,6.99,21432,,11,,metabolic process,cytosol;Golgi,catalytic activity;metal ion binding;protein binding,"Pf01087, Pf02744",2592,ENSG00000213930.11,GALT,9,Galactose metabolism; Metabolic pathways; Prolactin signaling pathway; Amino sugar and nucleotide sugar metabolism,,Defective GALT can cause Galactosemia; Galactose catabolism,11,High,1
Q14C86,GTPase-activating protein and VPS9 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=GAPVD1 PE=1 SV=2,0,71.699,11,13,53,13,1478,164.9,5.22,22816,,13,,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytosol;endosome;membrane,enzyme regulator activity;protein binding,"Pf00616, Pf02204, Pf03344",26130,ENSG00000165219.21,GAPVD1,9,,,RAB GEFs exchange GTP for GDP on RABs; Clathrin-mediated endocytosis,5,High,1
Q7LG56,Ribonucleoside-diphosphate reductase subunit M2 B OS=Homo sapiens OX=9606 GN=RRM2B PE=1 SV=1,0,71.685,32,10,52,10,351,40.7,4.97,23874,,10,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;mitochondrion;nucleus,catalytic activity;metal ion binding;protein binding,Pf00268,50484,ENSG00000048392.11,RRM2B,8,p53 signaling pathway; Pyrimidine metabolism; Glutathione metabolism; Metabolic pathways; Purine metabolism,miRNA Regulation of DNA Damage Response; Nucleotide Metabolism; DNA Damage Response,Interconversion of nucleotide di- and triphosphates; TP53 Regulates Metabolic Genes,16,High,1
Q9UBT2,SUMO-activating enzyme subunit 2 OS=Homo sapiens OX=9606 GN=UBA2 PE=1 SV=2,0,71.662,29,14,59,14,640,71.2,5.29,20786,0,14,1,metabolic process;regulation of biological process,cytoplasm;nucleus,catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding,"Pf00899, Pf02134, Pf10585, Pf14732",10054,ENSG00000126261.12,UBA2,19,Ubiquitin mediated proteolysis,,"SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9)",7,High,1
Q16774,Guanylate kinase OS=Homo sapiens OX=9606 GN=GUK1 PE=1 SV=2,0,71.615,55,8,82,8,197,21.7,6.55,44225,,8,,metabolic process;transport,cytosol,catalytic activity;nucleotide binding;RNA binding,"Pf00005, Pf00625, Pf00910, Pf01926, Pf03193, Pf05729, Pf13173, Pf13191, Pf13207, Pf13401, Pf13521, Pf13555, Pf13671",2987,ENSG00000143774.16,GUK1,1,Purine metabolism; Metabolic pathways,,Interconversion of nucleotide di- and triphosphates; Abacavir metabolism,7,High,1
Q8N6H7,ADP-ribosylation factor GTPase-activating protein 2 OS=Homo sapiens OX=9606 GN=ARFGAP2 PE=1 SV=1,0,71.599,35,12,47,11,521,56.7,7.99,21738,5.95,11,2,regulation of biological process;transport,cytoplasm;cytosol;Golgi;membrane,enzyme regulator activity;metal ion binding,Pf01412,84364,ENSG00000149182.14,ARFGAP2,11,Endocytosis,,COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport,12,High,1
Q96AG3,Solute carrier family 25 member 46 OS=Homo sapiens OX=9606 GN=SLC25A46 PE=1 SV=1,0,71.599,33,8,72,8,418,46.1,7.43,28888,16.84,7,1,cell organization and biogenesis;transport,membrane;mitochondrion,protein binding,Pf00153,91137,ENSG00000164209.16,SLC25A46,5,,,,0,High,1
Q9BUB7,"Transmembrane protein 70, mitochondrial OS=Homo sapiens OX=9606 GN=TMEM70 PE=1 SV=2",0,71.558,30,8,131,8,260,29,8.91,60520,0,8,2,cell organization and biogenesis,membrane;mitochondrion,,Pf06979,54968,ENSG00000175606.10,TMEM70,8,,,,0,High,1
P22234,Multifunctional protein ADE2 OS=Homo sapiens OX=9606 GN=PAICS PE=1 SV=3,0,71.521,25,10,114,10,425,47,7.23,52383,,10,,metabolic process,cytoplasm;cytosol;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00731, Pf01259",10606,ENSG00000128050.8,PAICS,4,Purine metabolism; Metabolic pathways,,Purine ribonucleoside monophosphate biosynthesis,6,High,1
Q96EK5,KIF-binding protein OS=Homo sapiens OX=9606 GN=KIFBP PE=1 SV=1,0,71.397,35,13,66,13,621,71.8,5.49,25513,0,13,1,cell differentiation;development;transport,cytoplasm;cytoskeleton;mitochondrion,protein binding,Pf12309,26128,ENSG00000198954.7,KIAA1279; KIF1BP,10,,,,0,High,1
Q99627,COP9 signalosome complex subunit 8 OS=Homo sapiens OX=9606 GN=COPS8 PE=1 SV=1,0,71.363,54,8,116,8,209,23.2,5.38,44688,1.68,8,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,protein binding,Pf10075,10920,ENSG00000198612.10,COPS8,2,,,Cargo recognition for clathrin-mediated endocytosis; DNA Damage Recognition in GG-NER; Formation of TC-NER Pre-Incision Complex; Neddylation,13,High,1
Q969Z3,Mitochondrial amidoxime reducing component 2 OS=Homo sapiens OX=9606 GN=MARC2 PE=1 SV=1,0,71.363,33,11,228,9,335,38,9.16,115054,7.58,9,2,metabolic process;response to stimulus,membrane;mitochondrion,catalytic activity;metal ion binding,"Pf03473, Pf03476",54996,ENSG00000117791.15,MARC2,1,,,Phase I - Functionalization of compounds,3,High,1
P23142,Fibulin-1 OS=Homo sapiens OX=9606 GN=FBLN1 PE=1 SV=4,0,71.323,16,8,44,5,703,77.2,5.22,24941,,8,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,extracellular,enzyme regulator activity;metal ion binding;protein binding;structural molecule activity,"Pf01821, Pf07645, Pf12662, Pf14670",2192,ENSG00000077942.18,FBLN1,22,,,Molecules associated with elastic fibres,3,High,1
Q5T447,E3 ubiquitin-protein ligase HECTD3 OS=Homo sapiens OX=9606 GN=HECTD3 PE=1 SV=1,0,71.297,19,14,203,14,861,97.1,5.64,86801,,14,,metabolic process,cytoplasm,catalytic activity;protein binding,"Pf00632, Pf00754, Pf03256",79654,ENSG00000126107.14,HECTD3,1,,,Antigen processing: Ubiquitination & Proteasome degradation,4,High,1
Q96S66,Chloride channel CLIC-like protein 1 OS=Homo sapiens OX=9606 GN=CLCC1 PE=1 SV=1,0,71.296,37,14,55,14,551,62,5.55,19760,,14,,transport,endoplasmic reticulum;Golgi;membrane;nucleus,transporter activity,Pf05934,23155,ENSG00000121940.15,CLCC1,1,,,,0,High,1
P62841,40S ribosomal protein S15 OS=Homo sapiens OX=9606 GN=RPS15 PE=1 SV=2,0,71.296,41,4,266,4,145,17,10.39,105273,0,4,1,cell differentiation;cell organization and biogenesis;metabolic process;transport,cytosol;membrane;nucleus;ribosome,DNA binding;protein binding;RNA binding;structural molecule activity,Pf00203,6209,ENSG00000115268.9,RPS15,19,Ribosome,Cytoplasmic Ribosomal Proteins,"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane",38,High,1
Q8N1N4,"Keratin, type II cytoskeletal 78 OS=Homo sapiens OX=9606 GN=KRT78 PE=1 SV=2",0,71.278,19,14,271,7,520,56.8,6.02,140093,1.84,14,1,cell death,cytosol,structural molecule activity,"Pf00038, Pf12128, Pf13166",196374,ENSG00000170423.12,KRT78,12,,,Formation of the cornified envelope,3,High,1
P53007,"Tricarboxylate transport protein, mitochondrial OS=Homo sapiens OX=9606 GN=SLC25A1 PE=1 SV=2",0,71.218,25,8,291,8,311,34,9.89,123022,,8,,metabolic process;transport,membrane;mitochondrion;nucleus,transporter activity,Pf00153,6576,ENSG00000100075.9,SLC25A1,22,,,Gluconeogenesis; Fatty acyl-CoA biosynthesis,7,High,1
Q8N0W3,L-fucose kinase OS=Homo sapiens OX=9606 GN=FCSK PE=1 SV=2,0,71.083,21,15,42,15,1084,117.5,6.25,15818,,15,,metabolic process,cytoplasm;cytosol,catalytic activity;nucleotide binding,Pf07959,197258,ENSG00000157353.16,FUK,16,Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Fructose and mannose metabolism,,GDP-fucose biosynthesis,9,High,1
Q96AX1,Vacuolar protein sorting-associated protein 33A OS=Homo sapiens OX=9606 GN=VPS33A PE=1 SV=1,0,71.018,21,12,55,12,596,67.6,6.96,29751,,12,,cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;transport,endosome;membrane;vacuole,protein binding,Pf00995,65082,ENSG00000139719.9,VPS33A,12,,,,0,High,1
Q9UGT4,Sushi domain-containing protein 2 OS=Homo sapiens OX=9606 GN=SUSD2 PE=1 SV=1,0,71.005,21,9,62,9,822,90.2,6.28,22228,1.9,9,1,regulation of biological process;response to stimulus;transport,membrane,protein binding;receptor activity,"Pf00084, Pf00094, Pf01033, Pf03782",56241,ENSG00000099994.10,SUSD2,22,,,,0,High,1
Q9P2W9,Syntaxin-18 OS=Homo sapiens OX=9606 GN=STX18 PE=1 SV=1,0,70.934,47,12,37,12,335,38.7,5.49,18958,,12,,cell organization and biogenesis;regulation of biological process;transport,endoplasmic reticulum;Golgi;membrane,protein binding,Pf10496,53407,ENSG00000168818.9,STX18,4,SNARE interactions in vesicular transport; Phagosome,,COPI-dependent Golgi-to-ER retrograde traffic,7,High,1
P48739,Phosphatidylinositol transfer protein beta isoform OS=Homo sapiens OX=9606 GN=PITPNB PE=1 SV=2,0,70.799,43,11,124,9,271,31.5,6.87,57733,,11,,cell organization and biogenesis;metabolic process;transport,cytoplasm;Golgi;membrane,transporter activity,Pf02121,23760,ENSG00000180957.17,PITPNB,22,,,PI and PC transport between ER and Golgi membranes,6,High,1
Q9BTU6,Phosphatidylinositol 4-kinase type 2-alpha OS=Homo sapiens OX=9606 GN=PI4K2A PE=1 SV=1,0,70.794,39,14,58,14,479,54,8.29,22252,,14,,cell organization and biogenesis;defense response;metabolic process;response to stimulus,cytosol;endosome;Golgi;membrane;mitochondrion,catalytic activity;metal ion binding;nucleotide binding;protein binding,Pf00454,55361,ENSG00000155252.13,PI4K2A,10,Metabolic pathways; Phosphatidylinositol signaling system; Inositol phosphate metabolism,Wnt Signaling Pathway Netpath,Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane,11,High,1
Q9HA64,Ketosamine-3-kinase OS=Homo sapiens OX=9606 GN=FN3KRP PE=1 SV=2,0,70.787,30,8,90,8,309,34.4,7.33,42488,,8,,metabolic process,cytosol,catalytic activity;enzyme regulator activity,"Pf01636, Pf03881",79672,ENSG00000141560.14,FN3KRP,17,,,"Gamma carboxylation, hypusine formation and arylsulfatase activation",3,High,1
P52594,Arf-GAP domain and FG repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=AGFG1 PE=1 SV=2,0,70.727,22,7,44,7,562,58.2,8.63,18486,,7,,cell differentiation;cell organization and biogenesis;development;regulation of biological process;transport,cytosol;nucleus,DNA binding;enzyme regulator activity;metal ion binding;protein binding;RNA binding,Pf01412,3267,ENSG00000173744.17,AGFG1,2,Influenza A,,Cargo recognition for clathrin-mediated endocytosis,5,High,1
Q6PML9,Zinc transporter 9 OS=Homo sapiens OX=9606 GN=SLC30A9 PE=1 SV=1,0,70.691,24,12,89,12,568,63.5,8.32,37153,2.39,11,1,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoskeleton;endoplasmic reticulum;membrane;nucleus,protein binding;transporter activity,Pf01545,10463,ENSG00000014824.13,SLC30A9,4,,Zinc homeostasis,,1,High,1
P01880,Immunoglobulin heavy constant delta OS=Homo sapiens OX=9606 GN=IGHD PE=1 SV=3,0,70.675,28,10,74,10,384,42.3,8.12,35993,8.19,9,1,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,protein binding,"Pf00047, Pf07654",3495,ENSG00000211898.7,IGHD,14,,,CD22 mediated BCR regulation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers,5,High,1
E7EW31,Proline-rich basic protein 1 OS=Homo sapiens OX=9606 GN=PROB1 PE=2 SV=2,0,70.421,14,8,61,8,1015,106.9,9.63,11845,105.45,1,7,,,,Pf15232,389333,ENSG00000228672.3,PROB1,5,,,,0,High,1
Q8WUH6,Transmembrane protein 263 OS=Homo sapiens OX=9606 GN=TMEM263 PE=1 SV=1,0,70.417,84,8,107,8,116,11.7,9.32,40634,,8,,,membrane,,Pf15475,90488,ENSG00000151135.9,C12orf23; TMEM263,12,,,,0,High,1
Q99541,Perilipin-2 OS=Homo sapiens OX=9606 GN=PLIN2 PE=1 SV=2,0,70.392,36,11,50,11,437,48,6.8,20329,,11,,regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;extracellular;membrane;nucleus,,Pf03036,123,ENSG00000147872.9,PLIN2,9,PPAR signaling pathway,Adipogenesis,PPARA activates gene expression,6,High,1
Q9NQX3,Gephyrin OS=Homo sapiens OX=9606 GN=GPHN PE=1 SV=1,0,70.375,23,14,53,14,736,79.7,5.43,24820,,14,,cell organization and biogenesis;metabolic process;response to stimulus,cytoplasm;cytoskeleton;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00994, Pf03453, Pf03454",10243,ENSG00000171723.15,GPHN,14,Folate biosynthesis; Metabolic pathways; GABAergic synapse,,Molybdenum cofactor biosynthesis,7,High,1
Q9H993,Damage-control phosphatase ARMT1 OS=Homo sapiens OX=9606 GN=ARMT1 PE=1 SV=1,0,70.287,37,13,112,13,441,51.1,5.76,46159,4.8,12,2,metabolic process;regulation of biological process;response to stimulus,,catalytic activity;protein binding,Pf01937,79624,ENSG00000146476.10,C6orf211; ARMT1,6,,,,0,High,1
Q96S52,GPI transamidase component PIG-S OS=Homo sapiens OX=9606 GN=PIGS PE=1 SV=3,0,70.287,26,11,44,11,555,61.6,6.49,18242,,11,,metabolic process,endoplasmic reticulum;membrane,catalytic activity;protein binding,Pf10510,94005,ENSG00000087111.20,PIGS,17,Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways,,Attachment of GPI anchor to uPAR,6,High,1
P48751,Anion exchange protein 3 OS=Homo sapiens OX=9606 GN=SLC4A3 PE=2 SV=2,0,70.272,13,11,49,9,1232,135.7,6.44,9467,73.15,4,7,cellular homeostasis;transport,membrane,transporter activity,"Pf00955, Pf07565",6508,ENSG00000114923.16,SLC4A3,2,,,Bicarbonate transporters,4,High,1
P30040,Endoplasmic reticulum resident protein 29 OS=Homo sapiens OX=9606 GN=ERP29 PE=1 SV=4,0,70.267,34,9,339,9,261,29,7.31,175353,,9,,metabolic process;regulation of biological process;transport,cell surface;endoplasmic reticulum;membrane;organelle lumen,catalytic activity;protein binding,"Pf07749, Pf07912",10961,ENSG00000089248.6,ERP29,12,Protein processing in endoplasmic reticulum,,,1,High,1
P49841,Glycogen synthase kinase-3 beta OS=Homo sapiens OX=9606 GN=GSK3B PE=1 SV=2,0,70.26,34,9,69,7,420,46.7,8.78,31796,0,9,1,cell differentiation;cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;mitochondrion;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf01636, Pf07714, Pf14531",2932,ENSG00000082701.14,GSK3B,3,Breast cancer; Focal adhesion; Signaling pathways regulating pluripotency of stem cells; B cell receptor signaling pathway; HTLV-I infection; Chemokine signaling pathway; Prolactin signaling pathway; Prostate cancer; Measles; Dopaminergic synapse; Colorectal cancer; mTOR signaling pathway; Insulin resistance; Hippo signaling pathway; Wnt signaling pathway; Basal cell carcinoma; Epstein-Barr virus infection; EGFR tyrosine kinase inhibitor resistance; Cell cycle; T cell receptor signaling pathway; Pathways in cancer; Hedgehog signaling pathway; PI3K-Akt signaling pathway; Alzheimer's disease; Melanogenesis; Thyroid hormone signaling pathway; ErbB signaling pathway; Endometrial cancer; Neurotrophin signaling pathway; Insulin signaling pathway; Influenza A; Axon guidance; Hepatitis C; Non-alcoholic fatty liver disease (NAFLD),IL-5 Signaling Pathway; Androgen receptor signaling pathway; Energy Metabolism; MicroRNAs in cardiomyocyte hypertrophy; Cell Cycle; Leptin signaling pathway; TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway; Prolactin Signaling Pathway; Regulation of Microtubule Cytoskeleton; IL-7 Signaling Pathway; Alzheimers Disease; Neural Crest Differentiation; IL17 signaling pathway; B Cell Receptor Signaling Pathway; Corticotropin-releasing hormone signaling pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Cardiac Progenitor Differentiation; T-Cell Receptor and Co-stimulatory Signaling; Cardiac Hypertrophic Response; Focal Adhesion; Copper homeostasis; Melatonin metabolism and effects; Wnt Signaling Pathway Netpath; IL-6 signaling pathway; Wnt/beta-catenin Signaling Pathway in Leukemia; Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds; Association Between Physico-Chemical Features and Toxicity Associated Pathways; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection; Regulation of Apoptosis by Parathyroid Hormone-related Protein; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; Chemokine signaling pathway; ESC Pluripotency Pathways; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Wnt Signaling Pathway and Pluripotency; Wnt Signaling Pathway; Insulin Signaling; Glycogen Metabolism; Notch Signaling Pathway; Senescence and Autophagy in Cancer; ErbB Signaling Pathway; DNA Damage Response (only ATM dependent),Regulation of RUNX2 expression and activity; AKT phosphorylates targets in the cytosol; S37 mutants of beta-catenin aren't phosphorylated; Beta-catenin phosphorylation cascade; AXIN missense mutants destabilize the destruction complex; S33 mutants of beta-catenin aren't phosphorylated; CRMPs in Sema3A signaling; Regulation of HSF1-mediated heat shock response; Disassembly of the destruction complex and recruitment of AXIN to the membrane; APC truncation mutants have impaired AXIN binding; S45 mutants of beta-catenin aren't phosphorylated; GLI3 is processed to GLI3R by the proteasome; Misspliced GSK3beta mutants stabilize beta-catenin; Constitutive Signaling by AKT1 E17K in Cancer; Degradation of GLI2 by the proteasome; T41 mutants of beta-catenin aren't phosphorylated; B-WICH complex positively regulates rRNA expression; Truncations of AMER1 destabilize the destruction complex,124,High,1
O14925,Mitochondrial import inner membrane translocase subunit Tim23 OS=Homo sapiens OX=9606 GN=TIMM23 PE=1 SV=1,0,70.216,58,6,68,6,209,21.9,8.6,31799,0,6,1,transport,membrane;mitochondrion,protein binding;transporter activity,Pf02466,100287932,ENSG00000265354.3,TIMM23,10,,,Mitochondrial protein import; Metabolism of proteins,2,High,1
O60282,Kinesin heavy chain isoform 5C OS=Homo sapiens OX=9606 GN=KIF5C PE=1 SV=1,0,70.189,11,10,87,1,957,109.4,6.19,42745,,10,,cell organization and biogenesis;cellular component movement;transport,cytoplasm;cytoskeleton,catalytic activity;motor activity;nucleotide binding;protein binding,"Pf00225, Pf04156",3800,ENSG00000168280.16,KIF5C,2,Dopaminergic synapse; Endocytosis,,Insulin processing,5,High,1
Q6WCQ1,Myosin phosphatase Rho-interacting protein OS=Homo sapiens OX=9606 GN=MPRIP PE=1 SV=3,0,70.158,22,17,43,17,1025,116.5,6.21,15077,,17,,,cytoplasm;cytoskeleton;cytosol,protein binding,Pf00169,23164,ENSG00000133030.20,MPRIP,17,,,Signaling by BRAF and RAF fusions,4,High,1
Q9NRY4,Rho GTPase-activating protein 35 OS=Homo sapiens OX=9606 GN=ARHGAP35 PE=1 SV=3,0,70.082,13,15,55,15,1499,170.4,6.64,20834,,15,,cell communication;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,catalytic activity;DNA binding;enzyme regulator activity;nucleotide binding,"Pf00071, Pf00620, Pf02421",2909,ENSG00000160007.18,ARHGAP35,19,Platelet activation; Regulation of actin cytoskeleton; Leukocyte transendothelial migration; Focal adhesion,Regulation of Actin Cytoskeleton,"Sema4D mediated inhibition of cell attachment and migration; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; Rho GTPase cycle",16,High,1
Q9ULQ0,Striatin-interacting protein 2 OS=Homo sapiens OX=9606 GN=STRIP2 PE=1 SV=2,0,70.007,15,11,55,9,834,95.3,5.91,24717,8.11,11,1,cell organization and biogenesis;cellular component movement;regulation of biological process,cytoplasm;cytosol,,"Pf07923, Pf11882",57464,ENSG00000128578.9,STRIP2,7,,,,0,High,1
Q7L3T8,"Probable proline--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=PARS2 PE=1 SV=1",0,69.982,24,10,110,10,475,53.2,8.1,59023,0,10,1,metabolic process,cytoplasm;mitochondrion;organelle lumen,catalytic activity;nucleotide binding,"Pf00587, Pf03129",25973,ENSG00000162396.5,PARS2,1,Aminoacyl-tRNA biosynthesis,,Mitochondrial tRNA aminoacylation,5,High,1
Q9BV79,"Enoyl-[acyl-carrier-protein] reductase, mitochondrial OS=Homo sapiens OX=9606 GN=MECR PE=1 SV=2",0,69.876,34,10,201,10,373,40.4,8.76,104713,0,9,2,metabolic process,cytoplasm;mitochondrion;nucleus;organelle lumen,catalytic activity,"Pf00107, Pf08240",51102,ENSG00000116353.15,MECR,1,Fatty acid elongation; Metabolic pathways; Fatty acid metabolism,Fatty Acid Biosynthesis,Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA,10,High,1
O75844,CAAX prenyl protease 1 homolog OS=Homo sapiens OX=9606 GN=ZMPSTE24 PE=1 SV=2,0,69.828,28,11,118,11,475,54.8,7.49,45650,0,11,1,cell organization and biogenesis;metabolic process,endoplasmic reticulum;membrane;nucleus,catalytic activity;metal ion binding;protein binding,Pf01435,10269,ENSG00000084073.8,ZMPSTE24,1,Terpenoid backbone biosynthesis,Adipogenesis,,2,High,1
Q9HCB6,Spondin-1 OS=Homo sapiens OX=9606 GN=SPON1 PE=1 SV=2,0,69.821,18,10,61,10,807,90.9,6.11,26732,,10,,metabolic process,extracellular;organelle lumen,metal ion binding;protein binding,"Pf00090, Pf02014, Pf06468",10418,ENSG00000262655.3,SPON1,11,,,O-glycosylation of TSR domain-containing proteins; Defective B3GALTL causes Peters-plus syndrome (PpS),8,High,1
Q96Q11,"CCA tRNA nucleotidyltransferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=TRNT1 PE=1 SV=2",0,69.754,34,12,79,12,434,50.1,8.1,33337,,12,,cell organization and biogenesis;metabolic process,mitochondrion;organelle lumen,catalytic activity;nucleotide binding;RNA binding,"Pf01743, Pf12627",51095,ENSG00000072756.16,TRNT1,3,RNA transport,,tRNA processing in the mitochondrion; tRNA processing in the nucleus,5,High,1
Q9NPA0,ER membrane protein complex subunit 7 OS=Homo sapiens OX=9606 GN=EMC7 PE=1 SV=1,0,69.751,52,8,72,8,242,26.5,9.25,34498,,8,,,membrane,,Pf09430,56851,ENSG00000134153.9,EMC7,15,,,,0,High,1
P23142-4,Isoform C of Fibulin-1 OS=Homo sapiens OX=9606 GN=FBLN1,0,69.741,17,7,50,4,683,74.4,5.24,12497,70.53,3,4,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,extracellular,enzyme regulator activity;metal ion binding;protein binding;structural molecule activity,"Pf01821, Pf07645, Pf12662, Pf14670",2192,ENSG00000077942.18,FBLN1,22,,,,0,High,1
O75781,Paralemmin-1 OS=Homo sapiens OX=9606 GN=PALM PE=1 SV=2,0,69.662,37,9,54,9,387,42.1,5,22978,0,9,1,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cytoplasm;membrane;nucleus,protein binding,Pf03285,5064,ENSG00000099864.17,PALM,19,,,,0,High,1
P40855,Peroxisomal biogenesis factor 19 OS=Homo sapiens OX=9606 GN=PEX19 PE=1 SV=1,0,69.659,40,9,79,9,299,32.8,4.34,32358,,9,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;membrane;nucleus,protein binding,Pf04614,5824,ENSG00000162735.18,PEX19,1,Peroxisome,,ABC transporters in lipid homeostasis,4,High,1
Q96IJ6,Mannose-1-phosphate guanyltransferase alpha OS=Homo sapiens OX=9606 GN=GMPPA PE=1 SV=1,0,69.636,25,11,118,11,420,46.3,7.21,49786,,11,,metabolic process,cytoplasm,catalytic activity;protein binding,"Pf00132, Pf00483, Pf12804",29926,ENSG00000144591.18,GMPPA,2,Amino sugar and nucleotide sugar metabolism; Fructose and mannose metabolism; Metabolic pathways,,Synthesis of GDP-mannose,9,High,1
P63220,40S ribosomal protein S21 OS=Homo sapiens OX=9606 GN=RPS21 PE=1 SV=1,0,69.616,49,5,85,5,83,9.1,8.5,42725,,5,,cell organization and biogenesis;metabolic process;transport,cytosol;ribosome,protein binding;RNA binding;structural molecule activity,Pf01249,6227,ENSG00000171858.17,RPS21,20,Ribosome,Cytoplasmic Ribosomal Proteins,"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane",38,High,1
Q9UMS0,"NFU1 iron-sulfur cluster scaffold homolog, mitochondrial OS=Homo sapiens OX=9606 GN=NFU1 PE=1 SV=2",0,69.543,30,7,313,7,254,28.4,5.07,153507,,7,,cell organization and biogenesis;metabolic process,cytoplasm;cytosol;mitochondrion;nucleus,metal ion binding;protein binding,"Pf01106, Pf08712",27247,ENSG00000169599.12,NFU1,2,,,,0,High,1
Q9UIC8,Leucine carboxyl methyltransferase 1 OS=Homo sapiens OX=9606 GN=LCMT1 PE=1 SV=2,0,69.54,32,9,110,9,334,38.4,6.04,51898,,9,,metabolic process;regulation of biological process,cytosol,catalytic activity;protein binding,Pf04072,51451,ENSG00000205629.11,LCMT1,16,,,Cyclin A/B1/B2 associated events during G2/M transition,5,High,1
Q15819,Ubiquitin-conjugating enzyme E2 variant 2 OS=Homo sapiens OX=9606 GN=UBE2V2 PE=1 SV=4,0,69.509,61,9,268,3,145,16.4,8.09,118100,,9,,cell proliferation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,catalytic activity;protein binding,Pf00179,7336,ENSG00000169139.11,UBE2V2,8,,,G2/M DNA damage checkpoint; E3 ubiquitin ligases ubiquitinate target proteins; Formation of Incision Complex in GG-NER; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; Nonhomologous End-Joining (NHEJ); Antigen processing: Ubiquitination & Proteasome degradation,23,High,1
Q9P253,Vacuolar protein sorting-associated protein 18 homolog OS=Homo sapiens OX=9606 GN=VPS18 PE=1 SV=2,0,69.493,16,12,60,12,973,110.1,6.07,30405,,12,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,endosome;membrane;vacuole,catalytic activity;metal ion binding;protein binding,"Pf00637, Pf05131, Pf12861",57617,ENSG00000104142.10,VPS18,15,,,,0,High,1
Q9Y5K6,CD2-associated protein OS=Homo sapiens OX=9606 GN=CD2AP PE=1 SV=1,0,69.487,32,16,58,16,639,71.4,6.4,25418,,16,,cell division;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;membrane,protein binding;structural molecule activity,"Pf00018, Pf07653, Pf14604",23607,ENSG00000198087.7,CD2AP,6,Bacterial invasion of epithelial cells,Primary Focal Segmental Glomerulosclerosis FSGS,Nephrin family interactions,4,High,1
Q96C19,EF-hand domain-containing protein D2 OS=Homo sapiens OX=9606 GN=EFHD2 PE=1 SV=1,0,69.476,34,10,119,7,240,26.7,5.2,61025,,10,,,membrane,metal ion binding;protein binding,,79180,ENSG00000142634.12,EFHD2,1,,,,0,High,1
Q15526,Surfeit locus protein 1 OS=Homo sapiens OX=9606 GN=SURF1 PE=1 SV=1,0,69.468,33,8,88,8,300,33.3,9.6,43473,,8,,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion,catalytic activity;protein binding;transporter activity,Pf02104,6834,ENSG00000280627.2; ENSG00000148290.9,SURF1,9; CHR_HG2030_PATCH,,Electron Transport Chain; Type II diabetes mellitus,TP53 Regulates Metabolic Genes; Respiratory electron transport,11,High,1
Q9HA65,TBC1 domain family member 17 OS=Homo sapiens OX=9606 GN=TBC1D17 PE=1 SV=2,0,69.458,24,11,102,11,648,72.7,5.19,44986,,11,,metabolic process;regulation of biological process;transport,cytosol;endosome;vacuole,enzyme regulator activity;protein binding,"Pf00566, Pf12068",79735,,TBC1D17,19,,,TBC/RABGAPs,4,High,1
P52306,Rap1 GTPase-GDP dissociation stimulator 1 OS=Homo sapiens OX=9606 GN=RAP1GDS1 PE=1 SV=3,0,69.455,30,15,43,15,607,66.3,5.31,18072,,15,,cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus,cytosol;endoplasmic reticulum;mitochondrion,enzyme regulator activity;protein binding,Pf00514,5910,ENSG00000138698.14,RAP1GDS1,4,,,,0,High,1
O75351,Vacuolar protein sorting-associated protein 4B OS=Homo sapiens OX=9606 GN=VPS4B PE=1 SV=2,0,69.398,27,12,128,7,444,49.3,7.23,49324,0,12,1,cell communication;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane;nucleus,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00004, Pf00910, Pf01078, Pf01695, Pf04212, Pf04389, Pf06068, Pf07724, Pf07728, Pf09336, Pf13173, Pf13207, Pf13401",9525,ENSG00000119541.9,VPS4B,18,Endocytosis,,Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT),10,High,1
P42858,Huntingtin OS=Homo sapiens OX=9606 GN=HTT PE=1 SV=2,0,69.392,8,18,57,18,3142,347.4,6.2,21071,,18,,cell death;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;endosome;Golgi;membrane;nucleus;vacuole,protein binding;transporter activity,Pf12372,3064,ENSG00000197386.10,HTT,4,Huntington's disease,Mesodermal Commitment Pathway,,2,High,1
Q92879,CUGBP Elav-like family member 1 OS=Homo sapiens OX=9606 GN=CELF1 PE=1 SV=2,0,69.392,16,7,580,6,486,52,8.46,307081,,7,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;membrane;nucleus,protein binding;RNA binding;translation regulator activity,"Pf00076, Pf13893, Pf14259",10658,ENSG00000149187.17,CELF1,11,,Adipogenesis; mRNA Processing,,2,High,1
Q9BUJ2,Heterogeneous nuclear ribonucleoprotein U-like protein 1 OS=Homo sapiens OX=9606 GN=HNRNPUL1 PE=1 SV=2,0,69.384,17,12,72,12,856,95.7,6.92,30499,,12,,metabolic process;regulation of biological process;response to stimulus,nucleus,protein binding;RNA binding,"Pf00622, Pf02037, Pf13671",11100,ENSG00000105323.16,HNRNPUL1,19,Influenza A,,mRNA Splicing - Major Pathway,5,High,1
Q9NPJ3,Acyl-coenzyme A thioesterase 13 OS=Homo sapiens OX=9606 GN=ACOT13 PE=1 SV=1,0,69.309,68,8,441,8,140,15,9.14,222170,2,7,2,cell organization and biogenesis;metabolic process,cytoplasm;cytoskeleton;cytosol;mitochondrion;nucleus,catalytic activity,"Pf03061, Pf13622",55856,ENSG00000112304.10,ACOT13,6,,,Mitochondrial Fatty Acid Beta-Oxidation,4,High,1
P40616,ADP-ribosylation factor-like protein 1 OS=Homo sapiens OX=9606 GN=ARL1 PE=1 SV=1,0,69.257,53,7,112,7,181,20.4,5.72,54897,0,7,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;Golgi;membrane,catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,"Pf00025, Pf00071, Pf00503, Pf01926, Pf04670, Pf08477, Pf09439",400,ENSG00000120805.13,ARL1,12,,,Retrograde transport at the Trans-Golgi-Network,4,High,1
P10412,Histone H1.4 OS=Homo sapiens OX=9606 GN=H1-4 PE=1 SV=2,0,69.243,25,11,494,2,219,21.9,11.03,267219,3.01,11,3,cell organization and biogenesis;metabolic process;regulation of biological process,chromosome;nucleus,DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding,Pf00538,3008,ENSG00000168298.6,HIST1H1E,6,,Pathways Affected in Adenoid Cystic Carcinoma,Formation of Senescence-Associated Heterochromatin Foci (SAHF); Activation of DNA fragmentation factor,11,High,1
Q16512,Serine/threonine-protein kinase N1 OS=Homo sapiens OX=9606 GN=PKN1 PE=1 SV=2,0,69.222,17,12,189,11,942,103.9,6.37,76835,0,12,1,cell death;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endosome;membrane;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf00433, Pf02185, Pf07714, Pf14531, Pf15456",5585,ENSG00000123143.12,PKN1,19,Salmonella infection; PI3K-Akt signaling pathway,Apoptosis-related network due to altered Notch3 in ovarian cancer; G13 Signaling Pathway,Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3,9,High,1
Q6BCY4,NADH-cytochrome b5 reductase 2 OS=Homo sapiens OX=9606 GN=CYB5R2 PE=1 SV=1,0,69.135,11,5,268,1,276,31.4,8.5,135046,,5,,metabolic process;transport,membrane;mitochondrion;nucleus,catalytic activity;protein binding,"Pf00175, Pf00970, Pf08030",51700,ENSG00000166394.14,CYB5R2,11,Amino sugar and nucleotide sugar metabolism,Oxidation by Cytochrome P450,Erythrocytes take up carbon dioxide and release oxygen,5,High,1
P49247,Ribose-5-phosphate isomerase OS=Homo sapiens OX=9606 GN=RPIA PE=1 SV=3,0,69.132,34,8,74,8,311,33.2,8.54,34378,0,8,1,metabolic process,cytosol,catalytic activity;protein binding,"Pf00455, Pf06026",22934,ENSG00000153574.8,LOC101060545; RPIA,2,Pentose phosphate pathway; Metabolic pathways; Biosynthesis of amino acids; Carbon metabolism,Pentose Phosphate Pathway,RPIA deficiency: failed conversion of RU5P to R5P; RPIA deficiency: failed conversion of R5P to RU5P; Pentose phosphate pathway (hexose monophosphate shunt),14,High,1
Q9UG56,"Phosphatidylserine decarboxylase proenzyme, mitochondrial OS=Homo sapiens OX=9606 GN=PISD PE=2 SV=4",0,69.122,27,10,100,10,409,46.6,9.42,46250,,10,,metabolic process,membrane;mitochondrion;nucleus,catalytic activity,Pf02666,23761,ENSG00000241878.11,PISD,22,Glycerophospholipid metabolism; Metabolic pathways,,Synthesis of PE,7,High,1
Q7L1Q6,Basic leucine zipper and W2 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=BZW1 PE=1 SV=1,0,69.105,32,14,129,11,419,48,5.92,64146,,14,,metabolic process;regulation of biological process,cytoplasm;membrane,protein binding;RNA binding,Pf02020,9689,ENSG00000082153.17,BZW1,2,,,,0,High,1
Q8WZA0,Protein LZIC OS=Homo sapiens OX=9606 GN=LZIC PE=1 SV=1,0,69.062,41,8,63,8,190,21.5,4.94,34035,3.67,7,1,response to stimulus,,protein binding,Pf06384,84328,ENSG00000162441.11,LZIC,1,,,,0,High,1
P06132,Uroporphyrinogen decarboxylase OS=Homo sapiens OX=9606 GN=UROD PE=1 SV=2,0,68.912,34,8,80,8,367,40.8,6.14,33962,,8,,metabolic process,cytoplasm;cytosol,catalytic activity;protein binding,Pf01208,7389,ENSG00000126088.13,UROD,1,Porphyrin and chlorophyll metabolism; Metabolic pathways,Heme Biosynthesis,Heme biosynthesis,6,High,1
Q9BSD7,Cancer-related nucleoside-triphosphatase OS=Homo sapiens OX=9606 GN=NTPCR PE=1 SV=1,0,68.83,47,8,106,8,190,20.7,9.54,48881,,8,,metabolic process;response to stimulus,membrane,catalytic activity;nucleotide binding;RNA binding,"Pf00004, Pf00910, Pf01583, Pf03029, Pf03266, Pf05496, Pf07726, Pf07728, Pf13173, Pf13191, Pf13207, Pf13238",84284,ENSG00000135778.11,NTPCR,1,Thiamine metabolism; Metabolic pathways; Purine metabolism,,,3,High,1
A2RTX5,"Threonine--tRNA ligase 2, cytoplasmic OS=Homo sapiens OX=9606 GN=TARSL2 PE=1 SV=1",0,68.748,21,16,76,13,802,92.6,6.05,32586,,16,,metabolic process,cytoplasm,catalytic activity;nucleotide binding;protein binding,"Pf00587, Pf02824, Pf03129, Pf07973",123283,ENSG00000185418.15,TARSL2,15,Aminoacyl-tRNA biosynthesis,,,1,High,1
Q9Y6K5,2'-5'-oligoadenylate synthase 3 OS=Homo sapiens OX=9606 GN=OAS3 PE=1 SV=3,0,68.711,14,12,60,12,1087,121.1,8.4,25910,,12,,defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding,"Pf01909, Pf10421",4940,ENSG00000111331.12,OAS3,12,NOD-like receptor signaling pathway; Hepatitis C; Measles; Influenza A; Herpes simplex infection,,Interferon alpha/beta signaling; Interferon gamma signaling,10,High,1
Q9Y4F1,"FERM, ARHGEF and pleckstrin domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FARP1 PE=1 SV=1",0,68.697,16,11,61,11,1045,118.6,8.15,24529,,11,,cell organization and biogenesis;development;regulation of biological process,cytoplasm;cytoskeleton;cytosol;membrane,protein binding,"Pf00169, Pf00373, Pf00621, Pf08736, Pf09379, Pf09380",10160,ENSG00000152767.16,FARP1,13,,,,0,High,1
P16452,Erythrocyte membrane protein band 4.2 OS=Homo sapiens OX=9606 GN=EPB42 PE=1 SV=3,0,68.674,17,10,105,10,691,77,8.09,47336,,10,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytoskeleton;membrane,catalytic activity;nucleotide binding;protein binding;structural molecule activity,"Pf00868, Pf00927, Pf01841",2038,ENSG00000166947.11,EPB42,15,,,,0,High,1
O95816,BAG family molecular chaperone regulator 2 OS=Homo sapiens OX=9606 GN=BAG2 PE=1 SV=1,0,68.654,34,6,90,6,211,23.8,6.7,37775,,6,,metabolic process;regulation of biological process,cytosol,enzyme regulator activity;nucleotide binding;protein binding,Pf02179,9532,ENSG00000112208.11,BAG2,6,Protein processing in endoplasmic reticulum,,Regulation of HSF1-mediated heat shock response,5,High,1
Q9BRJ7,Tudor-interacting repair regulator protein OS=Homo sapiens OX=9606 GN=NUDT16L1 PE=1 SV=1,0,68.617,55,11,69,9,211,23.3,8.91,34446,,11,,regulation of biological process,nucleus,catalytic activity;protein binding;RNA binding,,84309,ENSG00000168101.14,NUDT16L1,16,Proteoglycans in cancer,,,1,High,1
O75608,Acyl-protein thioesterase 1 OS=Homo sapiens OX=9606 GN=LYPLA1 PE=1 SV=1,0,68.589,43,8,201,8,230,24.7,6.77,103576,,8,,metabolic process;regulation of biological process,cytoplasm;cytosol;mitochondrion,catalytic activity;protein binding,"Pf00561, Pf02230, Pf03959, Pf07859, Pf12695, Pf12697",10434,ENSG00000120992.17,LYPLA1,8,Choline metabolism in cancer; Glycerophospholipid metabolism,,eNOS activation,6,High,1
Q9NR50,Translation initiation factor eIF-2B subunit gamma OS=Homo sapiens OX=9606 GN=EIF2B3 PE=1 SV=1,0,68.582,34,13,64,13,452,50.2,6.47,27436,,13,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,catalytic activity;protein binding;RNA binding,"Pf00483, Pf02348, Pf12804",8891,ENSG00000070785.16,EIF2B3,1,RNA transport,Translation Factors,Recycling of eIF2:GDP,7,High,1
P35555,Fibrillin-1 OS=Homo sapiens OX=9606 GN=FBN1 PE=1 SV=4,0,68.58,5,13,379,13,2871,312.1,4.93,187724,1.66,11,3,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cell surface;extracellular;membrane;organelle lumen,metal ion binding;protein binding;structural molecule activity,"Pf00683, Pf06247, Pf07645, Pf12662, Pf12947, Pf14670",2200,ENSG00000166147.13,FBN1,15,,Hypothesized Pathways in Pathogenesis of Cardiovascular Disease,,1,High,1
Q14194,Dihydropyrimidinase-related protein 1 OS=Homo sapiens OX=9606 GN=CRMP1 PE=1 SV=1,0,68.566,16,9,289,3,572,62.1,7.03,148789,,9,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process,cytoplasm;cytoskeleton;cytosol,catalytic activity;protein binding,"Pf01979, Pf07969, Pf13147, Pf13594",1400,ENSG00000072832.14,CRMP1,4,,,CRMPs in Sema3A signaling,4,High,1
Q3YEC7,Rab-like protein 6 OS=Homo sapiens OX=9606 GN=RABL6 PE=1 SV=2,0,68.498,19,12,114,12,729,79.5,5.22,41901,,12,,regulation of biological process;response to stimulus,cytoplasm;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf08477",55684,ENSG00000196642.18,RABL6,9,,,,0,High,1
Q8N2U0,Transmembrane protein 256 OS=Homo sapiens OX=9606 GN=TMEM256 PE=3 SV=1,0,68.498,47,6,125,6,113,11.7,8.94,56242,0,5,2,,membrane,,Pf04241,254863,ENSG00000205544.3; ENSG00000283771.1,C17orf61; TMEM256,17; CHR_HG2046_PATCH,,,,0,High,1
Q96PK6,RNA-binding protein 14 OS=Homo sapiens OX=9606 GN=RBM14 PE=1 SV=2,0,68.486,21,13,65,13,669,69.4,9.67,25463,,13,,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",10432; 100526737,ENSG00000239306.4,RBM14; RBM14-RBM4,11,,,RUNX2 regulates bone development,5,High,1
Q99729-2,Isoform 2 of Heterogeneous nuclear ribonucleoprotein A/B OS=Homo sapiens OX=9606 GN=HNRNPAB,0,68.472,25,10,140,9,332,35.9,6.95,64997,8.83,9,2,cell organization and biogenesis;regulation of biological process,cytoplasm;nucleus,DNA binding;protein binding;RNA binding,"Pf00076, Pf08143, Pf13893, Pf14259",3182,ENSG00000197451.11,HNRNPAB,5,,Preimplantation Embryo; mRNA Processing,,2,High,1
P20338,Ras-related protein Rab-4A OS=Homo sapiens OX=9606 GN=RAB4A PE=1 SV=3,0,68.417,48,8,95,7,218,24.4,6.07,47303,0,8,1,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding;transporter activity,"Pf00009, Pf00025, Pf00071, Pf08477",5867,ENSG00000168118.11,RAB4A,1,Endocytosis,VEGFA-VEGFR2 Signaling Pathway; Insulin Signaling,Translocation of GLUT4 to the plasma membrane; MET receptor recycling; TBC/RABGAPs; Synthesis of PIPs at the plasma membrane; RAB geranylgeranylation,20,High,1
Q99569,Plakophilin-4 OS=Homo sapiens OX=9606 GN=PKP4 PE=1 SV=2,0,68.376,17,15,61,14,1192,131.8,8.94,28293,,15,,cell communication;cell death;cell organization and biogenesis;regulation of biological process,cytoplasm;cytoskeleton;membrane,protein binding,"Pf00514, Pf13646",8502,ENSG00000144283.21,PKP4,2,,,Formation of the cornified envelope,3,High,1
P14174,Macrophage migration inhibitory factor OS=Homo sapiens OX=9606 GN=MIF PE=1 SV=4,0,68.354,62,6,461,6,115,12.5,7.88,216802,16.1,5,1,cell organization and biogenesis;cell proliferation;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;cytosol;extracellular;organelle lumen,catalytic activity;protein binding,Pf01187,4282,ENSG00000276701.2; ENSG00000240972.1,MIF,22; CHR_HSCHR22_1_CTG7,Tyrosine metabolism; Phenylalanine metabolism,Adipogenesis; Spinal Cord Injury,Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Neutrophil degranulation; Interleukin-12 family signaling; Cell surface interactions at the vascular wall,13,High,1
Q14160,Protein scribble homolog OS=Homo sapiens OX=9606 GN=SCRIB PE=1 SV=4,0,68.278,11,13,63,11,1630,174.8,5.07,25586,,13,,cell communication;cell death;cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;development;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;membrane,catalytic activity;protein binding,"Pf00595, Pf12799, Pf13180, Pf13855, Pf14580",23513,,SCRIB,8,Viral carcinogenesis; Hippo signaling pathway,Human Thyroid Stimulating Hormone (TSH) signaling pathway,Asymmetric localization of PCP proteins,8,High,1
Q96L92,Sorting nexin-27 OS=Homo sapiens OX=9606 GN=SNX27 PE=1 SV=2,0,68.263,29,13,51,13,541,61.2,6.49,20178,,13,,regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane,protein binding,"Pf00595, Pf00787, Pf00788",81609,ENSG00000143376.12,SNX27,1,,,,0,High,1
Q9HAB8,Phosphopantothenate--cysteine ligase OS=Homo sapiens OX=9606 GN=PPCS PE=1 SV=2,0,68.243,41,12,127,12,311,34,6.71,59137,0,12,1,metabolic process,cytosol,catalytic activity,Pf04127,79717,ENSG00000127125.8,PPCS,1,Pantothenate and CoA biosynthesis; Metabolic pathways,,Coenzyme A biosynthesis,7,High,1
P50148,Guanine nucleotide-binding protein G(q) subunit alpha OS=Homo sapiens OX=9606 GN=GNAQ PE=1 SV=4,0,68.219,35,10,107,3,359,42.1,5.68,46787,,10,,coagulation;regulation of biological process;response to stimulus,cytoplasm;membrane;nucleus,catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,"Pf00025, Pf00503",2776,ENSG00000156052.10,GNAQ,9,Renin secretion; Glucagon signaling pathway; Inflammatory mediator regulation of TRP channels; Vascular smooth muscle contraction; Insulin secretion; Sphingolipid signaling pathway; Chagas disease (American trypanosomiasis); Endocrine and other factor-regulated calcium reabsorption; Long-term depression; Calcium signaling pathway; Rap1 signaling pathway; Pancreatic secretion; GnRH signaling pathway; cGMP-PKG signaling pathway; Adrenergic signaling in cardiomyocytes; Gastric acid secretion; Amoebiasis; Long-term potentiation; Aldosterone synthesis and secretion; Platelet activation; Dopaminergic synapse; Circadian entrainment; Melanogenesis; Cholinergic synapse; Huntington's disease; Glutamatergic synapse; Serotonergic synapse; African trypanosomiasis; Estrogen signaling pathway; Salivary secretion; Retrograde endocannabinoid signaling; Alzheimer's disease; Thyroid hormone synthesis; Gap junction; Pathways in cancer; Oxytocin signaling pathway,Human Thyroid Stimulating Hormone (TSH) signaling pathway; Regulation of Microtubule Cytoskeleton; Alzheimers Disease; Corticotropin-releasing hormone signaling pathway; Myometrial Relaxation and Contraction Pathways; G Protein Signaling Pathways; Circadian rythm related genes; Cell-type Dependent Selectivity of CCK2R Signaling; Calcium Regulation in the Cardiac Cell; Serotonin Receptor 2 and ELK-SRF/GATA4 signaling; Serotonin Receptor 2 and STAT3 Signaling,Thrombin signalling through proteinase activated receptors (PARs); Acetylcholine regulates insulin secretion; Gastrin-CREB signalling pathway via PKC and MAPK; Thromboxane signalling through TP receptor; ADP signalling through P2Y purinoceptor 1; Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion,64,High,1
Q9Y2J2-2,Isoform 2 of Band 4.1-like protein 3 OS=Homo sapiens OX=9606 GN=EPB41L3,0,68.123,17,13,84,1,865,96.5,5.43,37212,3.89,12,1,cell death;cell organization and biogenesis;regulation of biological process,cytoskeleton;cytosol;membrane,protein binding;structural molecule activity,"Pf00373, Pf04382, Pf05902, Pf08736, Pf09379, Pf09380",23136,ENSG00000082397.17,EPB41L3,18,,,,0,High,1
O15400,Syntaxin-7 OS=Homo sapiens OX=9606 GN=STX7 PE=1 SV=4,0,68.014,56,9,76,9,261,29.8,5.55,37736,0,9,1,cell organization and biogenesis;regulation of biological process;transport,endosome;membrane;vacuole,protein binding,"Pf05739, Pf14523",8417,ENSG00000079950.13,STX7,6,Phagosome; SNARE interactions in vesicular transport,,,2,High,1
Q9UHD1,Cysteine and histidine-rich domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CHORDC1 PE=1 SV=2,0,67.993,34,9,111,9,332,37.5,7.87,47795,0,9,1,metabolic process;regulation of biological process,,metal ion binding;nucleotide binding;protein binding,"Pf04968, Pf04969",26973,ENSG00000110172.11,CHORDC1,11,,,,0,High,1
Q9Y3B7,"39S ribosomal protein L11, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL11 PE=1 SV=1",0,67.951,55,10,100,10,192,20.7,9.91,46128,,10,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,protein binding;RNA binding;structural molecule activity,"Pf00298, Pf03946",65003,ENSG00000174547.13,MRPL11,11,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
P61254,60S ribosomal protein L26 OS=Homo sapiens OX=9606 GN=RPL26 PE=1 SV=1,0,67.946,37,10,257,10,145,17.2,10.55,113648,,10,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;ribosome,protein binding;RNA binding;structural molecule activity,Pf00467,6154,ENSG00000161970.12,RPL26,17,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
Q7L8L6,"FAST kinase domain-containing protein 5, mitochondrial OS=Homo sapiens OX=9606 GN=FASTKD5 PE=1 SV=1",0,67.897,23,13,43,13,764,86.5,8.13,20450,,13,,cell organization and biogenesis;metabolic process,mitochondrion,catalytic activity;protein binding;RNA binding,"Pf06743, Pf08368, Pf08373",60493,ENSG00000215251.3,FASTKD5,20,,,,0,High,1
Q9H0R6,"Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial OS=Homo sapiens OX=9606 GN=QRSL1 PE=1 SV=2",0,67.834,24,8,60,8,528,57.4,5.68,29088,,8,,cell organization and biogenesis;metabolic process;regulation of biological process,mitochondrion,catalytic activity;nucleotide binding;protein binding,Pf01425,55278,ENSG00000130348.11,QRSL1,6,Metabolic pathways; Aminoacyl-tRNA biosynthesis,,,2,High,1
Q7KZI7,Serine/threonine-protein kinase MARK2 OS=Homo sapiens OX=9606 GN=MARK2 PE=1 SV=2,0,67.821,19,14,62,10,788,87.9,9.72,28123,,14,,cell differentiation;cell organization and biogenesis;cellular component movement;development;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;membrane;mitochondrion,catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding;RNA binding,"Pf00069, Pf00627, Pf02149, Pf07714, Pf14531",2011,ENSG00000072518.20,MARK2,11,,Regulation of Microtubule Cytoskeleton,,1,High,1
Q8N122,Regulatory-associated protein of mTOR OS=Homo sapiens OX=9606 GN=RPTOR PE=1 SV=1,0,67.821,17,15,43,15,1335,148.9,6.89,15212,0,15,1,cell communication;cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;vacuole,DNA binding;enzyme regulator activity;protein binding,"Pf01602, Pf12717, Pf13646, Pf14538",57521,ENSG00000141564.13,RPTOR,17,PI3K-Akt signaling pathway; MicroRNAs in cancer; mTOR signaling pathway; Longevity regulating pathway - multiple species; Longevity regulating pathway; AMPK signaling pathway; Insulin signaling pathway,AMP-activated Protein Kinase (AMPK) Signaling; Target Of Rapamycin (TOR) Signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Angiopoietin Like Protein 8 Regulatory Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Interferon type I signaling pathways,HSF1-dependent transactivation; Energy dependent regulation of mTOR by LKB1-AMPK; Regulation of PTEN gene transcription; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Macroautophagy,31,High,1
Q8WTW3,Conserved oligomeric Golgi complex subunit 1 OS=Homo sapiens OX=9606 GN=COG1 PE=1 SV=1,0,67.721,15,9,40,9,980,108.9,7.31,20409,,9,,cell organization and biogenesis;transport,Golgi;membrane,protein binding,Pf08700,9382,ENSG00000166685.11,COG1,17,,,COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network,11,High,1
A0A0B4J1X5,Immunoglobulin heavy variable 3-74 OS=Homo sapiens OX=9606 GN=IGHV3-74 PE=3 SV=1,0,67.717,38,8,173,4,117,12.8,8.66,89800,,8,,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,protein binding,,28408,ENSG00000224650.2; ENSG00000282305.1,IGHV3-74,14; CHR_HSCHR14_3_CTG1,,,,0,High,1
P62942,Peptidyl-prolyl cis-trans isomerase FKBP1A OS=Homo sapiens OX=9606 GN=FKBP1A PE=1 SV=2,0,67.707,73,7,135,7,108,11.9,8.16,66052,0,5,2,cell organization and biogenesis;cell proliferation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;membrane,catalytic activity;protein binding;signal transducer activity,Pf00254,2280,ENSG00000088832.16,FKBP1A,20,,Target Of Rapamycin (TOR) Signaling; Spinal Cord Injury; Calcium Regulation in the Cardiac Cell; TGF-beta Receptor Signaling,TGFBR2 Kinase Domain Mutants in Cancer; TGFBR1 LBD Mutants in Cancer; TGF-beta receptor signaling activates SMADs; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); Calcineurin activates NFAT; TGFBR1 KD Mutants in Cancer,22,High,1
P41567,Eukaryotic translation initiation factor 1 OS=Homo sapiens OX=9606 GN=EIF1 PE=1 SV=1,0,67.646,61,6,91,1,113,12.7,7.44,45209,,6,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,protein binding;RNA binding,Pf01253,10209,ENSG00000173812.10,EIF1,17,RNA transport,Translation Factors,,2,High,1
Q13586,Stromal interaction molecule 1 OS=Homo sapiens OX=9606 GN=STIM1 PE=1 SV=3,0,67.644,23,14,54,14,685,77.4,6.67,24972,,14,,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;endoplasmic reticulum;membrane,metal ion binding;protein binding;transporter activity,"Pf00430, Pf00769, Pf04111, Pf07647",6786,ENSG00000167323.11,STIM1,11,Platelet activation; Calcium signaling pathway,,Ion homeostasis; Elevation of cytosolic Ca2+ levels; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers,13,High,1
O15355,Protein phosphatase 1G OS=Homo sapiens OX=9606 GN=PPM1G PE=1 SV=1,0,67.633,29,11,35,11,546,59.2,4.36,18043,,11,,metabolic process;regulation of biological process,cytoplasm;membrane;nucleus,catalytic activity;metal ion binding;protein binding,Pf00481,5496,ENSG00000115241.10,PPM1G,2,,mRNA Processing,,1,High,1
Q16821,Protein phosphatase 1 regulatory subunit 3A OS=Homo sapiens OX=9606 GN=PPP1R3A PE=1 SV=3,0,67.624,16,12,37,12,1122,125.7,5,,60.35,,12,metabolic process,membrane,protein binding,Pf03370,5506,ENSG00000154415.7,PPP1R3A,7,Insulin resistance; Insulin signaling pathway,Insulin Signaling,,3,High,1
Q01628,Interferon-induced transmembrane protein 3 OS=Homo sapiens OX=9606 GN=IFITM3 PE=1 SV=2,0,67.567,49,5,39,4,133,14.6,7.01,20922,,5,,defense response;regulation of biological process;response to stimulus,endosome;membrane;vacuole,protein binding,Pf04505,10410,ENSG00000142089.15,IFITM3,11,,,Interferon alpha/beta signaling,4,High,1
P98179,RNA-binding protein 3 OS=Homo sapiens OX=9606 GN=RBM3 PE=1 SV=1,0,67.559,49,5,95,5,157,17.2,8.91,48125,,5,,metabolic process;regulation of biological process,cytoplasm;nucleus,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",5935,ENSG00000102317.17,RBM3,X,,,,0,High,1
Q12857-3,Isoform 3 of Nuclear factor 1 A-type OS=Homo sapiens OX=9606 GN=NFIA,0,67.545,37,11,53,7,501,55,8.51,21427,22.82,10,1,cell organization and biogenesis;metabolic process;regulation of biological process,nucleus,DNA binding;protein binding,"Pf00859, Pf03165, Pf10524",4774,ENSG00000162599.15,NFIA,1,,,,0,High,1
O94906,Pre-mRNA-processing factor 6 OS=Homo sapiens OX=9606 GN=PRPF6 PE=1 SV=1,0,67.436,18,15,103,15,941,106.9,8.25,40351,,15,,cell organization and biogenesis;metabolic process;regulation of biological process,membrane;nucleus;spliceosomal complex,protein binding;RNA binding,"Pf06424, Pf13414, Pf14559",24148,ENSG00000101161.7,PRPF6,20,Spliceosome,mRNA Processing,mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway,7,High,1
Q9HBU9,Popeye domain-containing protein 2 OS=Homo sapiens OX=9606 GN=POPDC2 PE=2 SV=2,0,67.416,19,5,106,5,364,40.4,5.36,45865,62.9,4,3,regulation of biological process,membrane,,Pf04831,64091,ENSG00000121577.13,POPDC2,3,,,,0,High,1
Q9UMX5,Neudesin OS=Homo sapiens OX=9606 GN=NENF PE=1 SV=1,0,67.412,63,10,93,10,172,18.8,5.69,36832,,10,,regulation of biological process,extracellular;membrane,metal ion binding;protein binding,Pf00173,29937,ENSG00000117691.9,NENF,1,,,,0,High,1
Q13148,TAR DNA-binding protein 43 OS=Homo sapiens OX=9606 GN=TARDBP PE=1 SV=1,0,67.402,31,9,126,9,414,44.7,6.19,67292,,9,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,DNA binding;protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",23435,ENSG00000120948.16,TARDBP,1,,,,0,High,1
Q9H0E2,Toll-interacting protein OS=Homo sapiens OX=9606 GN=TOLLIP PE=1 SV=1,0,67.385,30,7,118,7,274,30.3,5.97,54131,,7,,cell communication;cell differentiation;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;organelle lumen,protein binding;signal transducer activity,"Pf00168, Pf02845",54472,ENSG00000078902.15,TOLLIP,11,Toll-like receptor signaling pathway,Regulation of toll-like receptor signaling pathway; IL-1 signaling pathway; Structural Pathway of Interleukin 1 (IL-1); Toll-like Receptor Signaling; Toll-like receptor signaling pathway,Interleukin-1 family signaling; Neutrophil degranulation,12,High,1
Q96DV4,"39S ribosomal protein L38, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL38 PE=1 SV=2",0,67.375,23,9,84,9,380,44.6,7.53,42076,,9,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,,Pf01161,64978,ENSG00000204316.12,MRPL38,17,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
P18084,Integrin beta-5 OS=Homo sapiens OX=9606 GN=ITGB5 PE=1 SV=1,0,67.337,18,11,88,10,799,88,6.06,35541,,11,,cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus,cell surface;membrane,protein binding;receptor activity,"Pf00362, Pf07965, Pf08725",3693,ENSG00000082781.11,ITGB5,3,ECM-receptor interaction; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Hypertrophic cardiomyopathy (HCM); Regulation of actin cytoskeleton; Phagosome; PI3K-Akt signaling pathway; Proteoglycans in cancer; Dilated cardiomyopathy,Integrin-mediated Cell Adhesion; Arrhythmogenic Right Ventricular Cardiomyopathy; miRNA targets in ECM and membrane receptors; Focal Adhesion; VEGFA-VEGFR2 Signaling Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,ECM proteoglycans; Integrin cell surface interactions; Cross-presentation of particulate exogenous antigens (phagosomes); Smooth Muscle Contraction; Molecules associated with elastic fibres; Syndecan interactions,29,High,1
Q9H0N5,Pterin-4-alpha-carbinolamine dehydratase 2 OS=Homo sapiens OX=9606 GN=PCBD2 PE=1 SV=4,0,67.306,36,4,152,4,130,14.4,9.11,58774,0,4,1,cell organization and biogenesis;metabolic process;regulation of biological process,mitochondrion;nucleus,catalytic activity;protein binding,Pf01329,84105,ENSG00000132570.14,PCBD2,5,,,,0,High,1
P03928,ATP synthase protein 8 OS=Homo sapiens OX=9606 GN=MT-ATP8 PE=1 SV=1,0,67.302,37,5,835,5,68,8,9.91,338897,1.96,5,1,cell organization and biogenesis;metabolic process;response to stimulus;transport,membrane;mitochondrion,catalytic activity;transporter activity,,4509,ENSG00000228253.1,ATP8,MT,Oxidative phosphorylation; Huntington's disease; Alzheimer's disease; Metabolic pathways; Parkinson's disease,Electron Transport Chain,Cristae formation; Formation of ATP by chemiosmotic coupling,13,High,1
Q9NRW1,Ras-related protein Rab-6B OS=Homo sapiens OX=9606 GN=RAB6B PE=1 SV=1,0,67.28,54,10,200,4,208,23.4,5.53,97964,0,10,1,regulation of biological process;response to stimulus;transport,cytosol;Golgi;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf02421, Pf04670, Pf08477",51560,ENSG00000154917.10,RAB6B,3,,,COPI-independent Golgi-to-ER retrograde traffic; TBC/RABGAPs; Retrograde transport at the Trans-Golgi-Network; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation,12,High,1
P01780,Immunoglobulin heavy variable 3-7 OS=Homo sapiens OX=9606 GN=IGHV3-7 PE=1 SV=2,0,67.235,39,7,143,4,117,12.9,6.57,71048,,7,,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity,,28452,ENSG00000282211.1; ENSG00000211938.2,IGHV3-7,14; CHR_HSCHR14_3_CTG1,,,FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis,26,High,1
Q5SQH8,Uncharacterized protein C6orf136 OS=Homo sapiens OX=9606 GN=C6orf136 PE=2 SV=1,0,67.218,21,8,141,8,315,35.8,8.78,65428,0,8,1,,,,Pf10184,221545,ENSG00000224120.9; ENSG00000233164.9; ENSG00000204564.11; ENSG00000206487.11; ENSG00000237100.9; ENSG00000233641.9; ENSG00000237012.9,C6orf136,6; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_DBB_CTG1,,,,0,High,1
Q9BQ52,Zinc phosphodiesterase ELAC protein 2 OS=Homo sapiens OX=9606 GN=ELAC2 PE=1 SV=2,0,67.201,21,11,74,11,826,92.2,7.9,31134,,11,,cell organization and biogenesis;metabolic process,mitochondrion;nucleus;organelle lumen,catalytic activity;metal ion binding;RNA binding,"Pf00753, Pf12706, Pf13691",60528,ENSG00000006744.18,ELAC2,17,RNA transport,,tRNA processing in the mitochondrion; rRNA processing in the mitochondrion; tRNA processing in the nucleus,7,High,1
P26447,Protein S100-A4 OS=Homo sapiens OX=9606 GN=S100A4 PE=1 SV=1,0,67.171,37,7,304,7,101,11.7,6.11,156904,1.8,7,3,cell organization and biogenesis;regulation of biological process,extracellular;nucleus,metal ion binding;protein binding;RNA binding,"Pf01023, Pf13499",6275,ENSG00000196154.11,S100A4,1,,,,0,High,1
P07225,Vitamin K-dependent protein S OS=Homo sapiens OX=9606 GN=PROS1 PE=1 SV=1,0,67.141,19,11,97,11,676,75.1,5.67,37404,,11,,cellular component movement;coagulation;metabolic process;regulation of biological process;transport,cell surface;extracellular;membrane;organelle lumen,enzyme regulator activity;metal ion binding,"Pf00054, Pf00594, Pf02210, Pf06247, Pf07645, Pf12662, Pf12947, Pf14670",5627,ENSG00000184500.14,PROS1,3,Complement and coagulation cascades,Complement and Coagulation Cascades,Platelet degranulation ; Regulation of Complement cascade; Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus; Common Pathway of Fibrin Clot Formation; Cell surface interactions at the vascular wall; Removal of aminoterminal propeptides from gamma-carboxylated proteins; Gamma-carboxylation of protein precursors,20,High,1
P01601,Immunoglobulin kappa variable 1D-16 OS=Homo sapiens OX=9606 GN=IGKV1D-16 PE=3 SV=2,0,67.056,48,9,60,1,117,12.7,7.74,33103,,9,,cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity;protein binding,"Pf00047, Pf07679, Pf07686, Pf13927",28901; 3514,ENSG00000241244.1,IGKV1D-16; IGKC,2,,,FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis,26,High,1
Q96P70,Importin-9 OS=Homo sapiens OX=9606 GN=IPO9 PE=1 SV=3,0,66.986,13,9,55,9,1041,115.9,4.81,25117,,9,,transport,cytoplasm;cytosol;membrane;nucleus,protein binding;transporter activity,Pf03810,55705,ENSG00000198700.9,IPO9,1,,,,0,High,1
O00178,GTP-binding protein 1 OS=Homo sapiens OX=9606 GN=GTPBP1 PE=1 SV=3,0,66.983,25,14,41,14,669,72.4,8.34,15806,,14,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;nucleotide binding;RNA binding,"Pf00009, Pf03143, Pf03144",9567,ENSG00000100226.15,GTPBP1,22,,,,0,High,1
O00483,Cytochrome c oxidase subunit NDUFA4 OS=Homo sapiens OX=9606 GN=NDUFA4 PE=1 SV=1,0,66.972,78,9,411,9,81,9.4,9.38,205942,39.78,8,2,metabolic process;transport,membrane;mitochondrion,catalytic activity;protein binding;transporter activity,Pf06522,4697,ENSG00000189043.9,NDUFA4,7,Oxidative phosphorylation; Huntington's disease; Metabolic pathways; Alzheimer's disease; Non-alcoholic fatty liver disease (NAFLD); Parkinson's disease,Electron Transport Chain; Oxidative phosphorylation,TP53 Regulates Metabolic Genes; Respiratory electron transport,17,High,1
O43678,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 OS=Homo sapiens OX=9606 GN=NDUFA2 PE=1 SV=3,0,66.957,68,8,367,8,99,10.9,9.57,209356,0,8,1,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion,catalytic activity,Pf05047,4695,ENSG00000131495.8,NDUFA2,5,Non-alcoholic fatty liver disease (NAFLD); Alzheimer's disease; Huntington's disease; Metabolic pathways; Oxidative phosphorylation; Parkinson's disease,Electron Transport Chain; Oxidative phosphorylation,Complex I biogenesis,13,High,1
Q9H9E3,Conserved oligomeric Golgi complex subunit 4 OS=Homo sapiens OX=9606 GN=COG4 PE=1 SV=3,0,66.852,22,14,42,14,785,89,5.19,17460,0,14,1,cell organization and biogenesis;transport,endoplasmic reticulum;Golgi;membrane,protein binding,Pf08318,25839,,COG4,16,,,COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network,11,High,1
Q9UNN5,FAS-associated factor 1 OS=Homo sapiens OX=9606 GN=FAF1 PE=1 SV=2,0,66.783,23,12,97,12,650,73.9,4.88,41330,2.7,11,2,cell death;metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,enzyme regulator activity;protein binding,"Pf00789, Pf14555",11124,ENSG00000185104.19,FAF1,1,,Retinoblastoma (RB) in Cancer; Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation; VEGFA-VEGFR2 Signaling Pathway,,3,High,1
Q8IVH4,"Methylmalonic aciduria type A protein, mitochondrial OS=Homo sapiens OX=9606 GN=MMAA PE=1 SV=1",0,66.769,31,12,83,12,418,46.5,9.29,36664,0,11,1,metabolic process,mitochondrion;organelle lumen,catalytic activity;nucleotide binding,"Pf03205, Pf03308, Pf12846, Pf13401",166785,ENSG00000151611.13,MMAA,4,,,"Cobalamin (Cbl, vitamin B12) transport and metabolism; Defective MMAA causes methylmalonic aciduria type cblA; Propionyl-CoA catabolism; Defective MUT causes methylmalonic aciduria mut type",14,High,1
O00273,DNA fragmentation factor subunit alpha OS=Homo sapiens OX=9606 GN=DFFA PE=1 SV=1,0,66.73,36,9,73,9,331,36.5,4.79,35930,,9,,cell death;metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;nucleus,enzyme regulator activity;protein binding,"Pf02017, Pf09033",1676,ENSG00000160049.11,DFFA,1,Apoptosis,Apoptosis; Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation,Activation of DNA fragmentation factor,8,High,1
Q9Y3D6,Mitochondrial fission 1 protein OS=Homo sapiens OX=9606 GN=FIS1 PE=1 SV=2,0,66.715,43,7,255,7,152,16.9,8.79,139447,24.62,6,2,cell death;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;membrane;mitochondrion,protein binding,"Pf14852, Pf14853",51024,ENSG00000214253.8,FIS1,7,,,,0,High,1
O00170,AH receptor-interacting protein OS=Homo sapiens OX=9606 GN=AIP PE=1 SV=2,0,66.71,38,9,58,9,330,37.6,6.29,25235,,9,,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane,protein binding;signal transducer activity,Pf00254,9049,,AIP,11,,Aryl Hydrocarbon Receptor; Aryl Hydrocarbon Receptor Pathway,Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Aryl hydrocarbon receptor signalling; Interleukin-12 family signaling,11,High,1
Q8N3J5,"Protein phosphatase 1K, mitochondrial OS=Homo sapiens OX=9606 GN=PPM1K PE=1 SV=1",0,66.683,31,9,146,9,372,41,6.74,61766,20.43,8,4,metabolic process,mitochondrion;organelle lumen,catalytic activity;metal ion binding;protein binding,"Pf00481, Pf13672",152926,ENSG00000163644.14,PPM1K,4,,,Branched-chain amino acid catabolism,3,High,1
Q9Y2R0,"Cytochrome c oxidase assembly factor 3 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=COA3 PE=1 SV=1",0,66.624,39,6,256,6,106,11.7,9.6,123709,0,6,1,cell organization and biogenesis;regulation of biological process,membrane;mitochondrion,protein binding,Pf09813,28958,ENSG00000183978.7,COA3,17,,,,0,High,1
Q96ND0,Protein FAM210A OS=Homo sapiens OX=9606 GN=FAM210A PE=1 SV=2,0,66.623,29,8,210,8,272,30.8,9.76,94223,,8,,,membrane;mitochondrion,,Pf06916,125228,ENSG00000177150.12,FAM210A,18,,,,0,High,1
Q9UHP9,Small muscular protein OS=Homo sapiens OX=9606 GN=SMPX PE=2 SV=3,0,66.616,64,5,285,5,88,9.6,9.16,126624,21.25,4,3,,cytoplasm;nucleus,,Pf15355,23676,ENSG00000091482.5,SMPX,X,,,,0,High,1
Q9H2H8,Peptidyl-prolyl cis-trans isomerase-like 3 OS=Homo sapiens OX=9606 GN=PPIL3 PE=1 SV=1,0,66.581,63,8,68,8,161,18.1,6.79,29034,5.48,7,1,metabolic process,spliceosomal complex,catalytic activity;protein binding,Pf00160,53938,ENSG00000240344.8,PPIL3,2,,,mRNA Splicing - Major Pathway,4,High,1
Q567U6,Coiled-coil domain-containing protein 93 OS=Homo sapiens OX=9606 GN=CCDC93 PE=1 SV=2,0,66.571,25,13,66,13,631,73.2,8.15,26135,,13,,transport,endosome,protein binding,Pf09762,54520,ENSG00000125633.10,CCDC93,2,,,,0,High,1
P08195,4F2 cell-surface antigen heavy chain OS=Homo sapiens OX=9606 GN=SLC3A2 PE=1 SV=3,0,66.514,26,12,52,12,630,68,5.01,21740,,12,,cell growth;cellular component movement;metabolic process;response to stimulus;transport,cell surface;cytosol;membrane;nucleus,catalytic activity;protein binding;RNA binding;transporter activity,Pf00128,6520,ENSG00000168003.16,SLC3A2,11,mTOR signaling pathway; Protein digestion and absorption,,Tryptophan catabolism; Basigin interactions; Amino acid transport across the plasma membrane,13,High,1
O60739,Eukaryotic translation initiation factor 1b OS=Homo sapiens OX=9606 GN=EIF1B PE=1 SV=2,0,66.478,61,6,99,1,113,12.8,7.37,48487,,6,,metabolic process;regulation of biological process,,protein binding;RNA binding,Pf01253,10289,ENSG00000114784.3,EIF1B,3,RNA transport,,,1,High,1
Q9UGP8,Translocation protein SEC63 homolog OS=Homo sapiens OX=9606 GN=SEC63 PE=1 SV=2,0,66.461,19,12,83,12,760,87.9,5.31,33010,,12,,cell organization and biogenesis;metabolic process;response to stimulus;transport,cytosol;endoplasmic reticulum;membrane;spliceosomal complex,nucleotide binding;protein binding;receptor activity;RNA binding;transporter activity,"Pf00183, Pf00226, Pf02724, Pf02889, Pf04774, Pf04889",11231,ENSG00000025796.13,SEC63,6,Protein export; Protein processing in endoplasmic reticulum,,XBP1(S) activates chaperone genes,6,High,1
Q5VW32,BRO1 domain-containing protein BROX OS=Homo sapiens OX=9606 GN=BROX PE=1 SV=1,0,66.429,31,11,128,10,411,46.4,7.65,49704,0,11,2,,membrane,protein binding,Pf03097,148362,ENSG00000162819.11,BROX,1,,,,0,High,1
Q687X5,Metalloreductase STEAP4 OS=Homo sapiens OX=9606 GN=STEAP4 PE=1 SV=1,0,66.392,26,8,72,8,459,51.9,9.29,32690,0,8,1,cell differentiation;metabolic process;transport,endosome;Golgi;membrane,catalytic activity;metal ion binding,"Pf01794, Pf03807",79689,ENSG00000127954.12,STEAP4,7,,Copper homeostasis,,1,High,1
Q15811,Intersectin-1 OS=Homo sapiens OX=9606 GN=ITSN1 PE=1 SV=3,0,66.339,13,16,51,15,1721,195.3,7.77,16906,,16,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;membrane,catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding;structural molecule activity,"Pf00018, Pf00168, Pf00169, Pf00621, Pf02050, Pf02463, Pf02841, Pf03938, Pf04111, Pf04502, Pf05557, Pf05667, Pf06818, Pf07653, Pf07946, Pf09726, Pf10174, Pf11559, Pf11600, Pf12128, Pf12718, Pf12763, Pf13868, Pf13904, Pf14523, Pf14604, Pf14915, Pf14943, Pf15346",6453,ENSG00000205726.14,ITSN1,21,,,Cargo recognition for clathrin-mediated endocytosis; G alpha (12/13) signalling events; EPHB-mediated forward signaling; NRAGE signals death through JNK; Rho GTPase cycle; Signalling by NGF,19,High,1
Q9Y291,"28S ribosomal protein S33, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS33 PE=1 SV=1",0,66.331,64,7,96,7,106,12.6,10.11,37299,13.51,6,2,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,structural molecule activity,Pf08293,51650,ENSG00000090263.15,MRPS33,7,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
Q99615,DnaJ homolog subfamily C member 7 OS=Homo sapiens OX=9606 GN=DNAJC7 PE=1 SV=2,0,66.269,24,11,83,11,494,56.4,6.96,37259,1.63,11,1,metabolic process;regulation of biological process,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,enzyme regulator activity;protein binding,"Pf00226, Pf00515, Pf07719, Pf13414, Pf13424, Pf13431, Pf13432",7266,ENSG00000168259.14,DNAJC7,17,,Constitutive Androstane Receptor Pathway,Regulation of HSF1-mediated heat shock response,5,High,1
Q9GZP4,PITH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PITHD1 PE=1 SV=1,0,66.261,57,9,100,9,211,24.2,5.74,42164,,9,,response to stimulus,nucleus,,Pf06201,57095,ENSG00000057757.9,PITHD1,1,,,,0,High,1
Q9NZ32,Actin-related protein 10 OS=Homo sapiens OX=9606 GN=ACTR10 PE=1 SV=1,0,66.204,29,9,71,9,417,46.3,7.37,32711,,9,,cellular component movement;transport,cytoplasm;cytoskeleton;cytosol;extracellular;organelle lumen,protein binding,Pf00022,55860,ENSG00000131966.13,ACTR10,14,,,COPI-independent Golgi-to-ER retrograde traffic; Neutrophil degranulation; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR),19,High,1
Q32MZ4,Leucine-rich repeat flightless-interacting protein 1 OS=Homo sapiens OX=9606 GN=LRRFIP1 PE=1 SV=2,0,66.202,13,9,42,3,808,89.2,4.65,21187,,9,,metabolic process;regulation of biological process,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,DNA binding;protein binding;RNA binding,"Pf04111, Pf09738, Pf12128, Pf13654",9208,ENSG00000124831.18,LRRFIP1,2,,,Signaling by cytosolic FGFR1 fusion mutants; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production,10,High,1
Q92575,UBX domain-containing protein 4 OS=Homo sapiens OX=9606 GN=UBXN4 PE=1 SV=2,0,66.158,17,5,69,5,508,56.7,6.38,29266,,5,,metabolic process;response to stimulus,cytosol;endoplasmic reticulum;membrane;nucleus,protein binding,Pf00789,23190,ENSG00000144224.16,UBXN4,2,,,,0,High,1
Q96BW9,"Phosphatidate cytidylyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=TAMM41 PE=1 SV=2",0,66.117,28,10,81,10,452,51,7.94,35806,,10,,metabolic process,membrane;mitochondrion,catalytic activity,Pf09139,132001,ENSG00000144559.10,TAMM41,3,,,,0,High,1
O00116,"Alkyldihydroxyacetonephosphate synthase, peroxisomal OS=Homo sapiens OX=9606 GN=AGPS PE=1 SV=1",0,66.109,22,10,46,10,658,72.9,7.34,19285,,10,,metabolic process,membrane;mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding,"Pf01565, Pf02913",8540,ENSG00000018510.13,AGPS,2,Peroxisome; Ether lipid metabolism; Metabolic pathways,Triacylglyceride Synthesis,Plasmalogen biosynthesis,7,High,1
Q9H6Z4,Ran-binding protein 3 OS=Homo sapiens OX=9606 GN=RANBP3 PE=1 SV=1,0,65.981,28,11,93,11,567,60.2,4.78,37595,,11,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;nucleus,enzyme regulator activity;protein binding,Pf00638,8498,ENSG00000031823.14,RANBP3,19,HTLV-I infection,,,1,High,1
Q9Y2J2,Band 4.1-like protein 3 OS=Homo sapiens OX=9606 GN=EPB41L3 PE=1 SV=2,0,65.972,13,13,83,1,1087,120.6,5.19,37564,,13,,cell death;cell organization and biogenesis;regulation of biological process,cytoplasm;cytoskeleton;cytosol;membrane,protein binding;structural molecule activity,"Pf00373, Pf04382, Pf05902, Pf08736, Pf09379, Pf09380",23136,ENSG00000082397.17,EPB41L3,18,Tight junction,,Neurexins and neuroligins,4,High,1
Q6FI81,Anamorsin OS=Homo sapiens OX=9606 GN=CIAPIN1 PE=1 SV=2,0,65.947,44,11,54,11,312,33.6,5.62,21891,,11,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;mitochondrion;nucleus,catalytic activity;metal ion binding;protein binding,"Pf05093, Pf08241",57019,ENSG00000005194.14,CIAPIN1,16,,,Cytosolic iron-sulfur cluster assembly,2,High,1
Q96TA2,ATP-dependent zinc metalloprotease YME1L1 OS=Homo sapiens OX=9606 GN=YME1L1 PE=1 SV=2,0,65.908,19,11,61,11,773,86.4,8.76,24236,0,11,1,cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;transport,membrane;mitochondrion,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00004, Pf01434",10730,ENSG00000136758.18,YME1L1,10,,,Processing of SMDT1,3,High,1
A6NKT7,RanBP2-like and GRIP domain-containing protein 3 OS=Homo sapiens OX=9606 GN=RGPD3 PE=3 SV=2,0,65.87,12,15,63,1,1758,197.4,6.33,23181,,15,,transport,,protein binding,"Pf00515, Pf00638, Pf01465, Pf07719, Pf13414, Pf13432",653489,ENSG00000153165.18,RGPD3,2,RNA transport,,,1,High,1
O14979,Heterogeneous nuclear ribonucleoprotein D-like OS=Homo sapiens OX=9606 GN=HNRNPDL PE=1 SV=3,0,65.826,19,7,136,1,420,46.4,9.57,71104,0,7,1,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus;spliceosomal complex,DNA binding;protein binding;RNA binding,"Pf00076, Pf08777, Pf13893, Pf14259",9987,ENSG00000152795.17,HNRNPDL; HNRPDL,4,,,Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Interleukin-12 family signaling,5,High,1
P30154,Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform OS=Homo sapiens OX=9606 GN=PPP2R1B PE=1 SV=3,0,65.797,13,6,165,1,601,66.2,4.94,80261,15.49,5,2,cell death;regulation of biological process,membrane,protein binding,"Pf13513, Pf13646",5519,ENSG00000137713.15,PPP2R1B,11,PI3K-Akt signaling pathway; mRNA surveillance pathway; Tight junction; Sphingolipid signaling pathway; AMPK signaling pathway; Chagas disease (American trypanosomiasis); Hippo signaling pathway; Hepatitis C; TGF-beta signaling pathway; Oocyte meiosis; Dopaminergic synapse; Long-term depression; Adrenergic signaling in cardiomyocytes,Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Wnt Signaling Pathway and Pluripotency; Glycogen Metabolism,"Glycolysis; AXIN missense mutants destabilize the destruction complex; PP2A-mediated dephosphorylation of key metabolic factors; APC truncation mutants have impaired AXIN binding; CTLA4 inhibitory signaling; Activated TLR4 signalling; Separation of Sister Chromatids; MASTL Facilitates Mitotic Progression; S37 mutants of beta-catenin aren't phosphorylated; S33 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; Misspliced GSK3beta mutants stabilize beta-catenin; Cyclin A/B1/B2 associated events during G2/M transition; T41 mutants of beta-catenin aren't phosphorylated; RAF activation; ERKs are inactivated; Beta-catenin phosphorylation cascade; Negative regulation of MAPK pathway; Platelet sensitization by LDL; Signaling by GPCR; Interleukin-20 family signaling; DARPP-32 events; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Regulation of TP53 Degradation; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Cyclin D associated events in G1; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; Truncations of AMER1 destabilize the destruction complex",125,High,1
Q9NX18,"Succinate dehydrogenase assembly factor 2, mitochondrial OS=Homo sapiens OX=9606 GN=SDHAF2 PE=1 SV=1",0,65.795,41,6,193,6,166,19.6,6.8,91656,2.03,6,1,cell organization and biogenesis;metabolic process;regulation of biological process,cytosol;mitochondrion;organelle lumen,protein binding,Pf03937,54949,ENSG00000167985.6,SDHAF2,11,,,,0,High,1
P23919,Thymidylate kinase OS=Homo sapiens OX=9606 GN=DTYMK PE=1 SV=4,0,65.79,55,13,85,13,212,23.8,8.27,32833,,13,,cell differentiation;cell proliferation;metabolic process;response to stimulus,cytoplasm;cytosol;mitochondrion;organelle lumen,catalytic activity;nucleotide binding,"Pf00406, Pf02223",1841,ENSG00000168393.12,DTYMK,2,Metabolic pathways; Pyrimidine metabolism,,Interconversion of nucleotide di- and triphosphates,5,High,1
Q05397,Focal adhesion kinase 1 OS=Homo sapiens OX=9606 GN=PTK2 PE=1 SV=2,0,65.752,16,14,72,13,1052,119.2,6.62,27893,,14,,cell differentiation;cell organization and biogenesis;cellular component movement;defense response;development;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf00373, Pf03623, Pf07714, Pf14531",5747,ENSG00000169398.19,PTK2,8,Endocrine resistance; Transcriptional misregulation in cancer; ErbB signaling pathway; Axon guidance; Bacterial invasion of epithelial cells; Focal adhesion; Amoebiasis; Regulation of actin cytoskeleton; PI3K-Akt signaling pathway; Proteoglycans in cancer; Chemokine signaling pathway; Pathways in cancer; Small cell lung cancer; VEGF signaling pathway; Leukocyte transendothelial migration,Androgen receptor signaling pathway; Integrin-mediated Cell Adhesion; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; Leptin signaling pathway; Prolactin Signaling Pathway; Corticotropin-releasing hormone signaling pathway; Alpha 6 Beta 4 signaling pathway; Primary Focal Segmental Glomerulosclerosis FSGS; Apoptosis-related network due to altered Notch3 in ovarian cancer; Focal Adhesion; Signaling of Hepatocyte Growth Factor Receptor; Overview of nanoparticle effects; MFAP5-mediated ovarian cancer cell motility and invasiveness; Rac1/Pak1/p38/MMP-2 pathway; TGF-beta Signaling Pathway; Association Between Physico-Chemical Features and Toxicity Associated Pathways; VEGFA-VEGFR2 Signaling Pathway; Chemokine signaling pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; EGF/EGFR Signaling Pathway; Regulation of Actin Cytoskeleton; ErbB Signaling Pathway,DCC mediated attractive signaling; Netrin mediated repulsion signals; MET activates PTK2 signaling; Signal regulatory protein family interactions; Apoptotic cleavage of cellular proteins; VEGFA-VEGFR2 Pathway; GRB2:SOS provides linkage to MAPK signaling for Integrins ; NCAM signaling for neurite out-growth; p130Cas linkage to MAPK signaling for integrins; EPHB-mediated forward signaling; RHO GTPases Activate WASPs and WAVEs; Regulation of actin dynamics for phagocytic cup formation; RAF/MAP kinase cascade; Interleukin-20 family signaling,78,High,1
O14737,Programmed cell death protein 5 OS=Homo sapiens OX=9606 GN=PDCD5 PE=1 SV=3,0,65.728,51,8,216,8,125,14.3,6.04,108798,1.61,8,3,cell death;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,DNA binding;enzyme regulator activity;protein binding,Pf01984,9141,ENSG00000105185.11,PDCD5,19,,,,0,High,1
Q6L8Q7,"2',5'-phosphodiesterase 12 OS=Homo sapiens OX=9606 GN=PDE12 PE=1 SV=2",0,65.717,27,11,77,11,609,67.3,6.57,30404,0,11,1,metabolic process;regulation of biological process;response to stimulus,mitochondrion;organelle lumen,catalytic activity;metal ion binding,Pf03372,201626,ENSG00000174840.8,PDE12,3,,,,0,High,1
Q92804,TATA-binding protein-associated factor 2N OS=Homo sapiens OX=9606 GN=TAF15 PE=1 SV=1,0,65.709,19,7,79,5,592,61.8,8.02,34691,,7,,regulation of biological process,cytoplasm;nucleus,DNA binding;metal ion binding;protein binding;RNA binding,"Pf00076, Pf00641, Pf13893, Pf14259",8148,ENSG00000270647.5; ENSG00000276833.2,TAF15,17; CHR_HSCHR17_7_CTG4,Basal transcription factors; Transcriptional misregulation in cancer,,,2,High,1
Q5T8D3-3,Isoform 3 of Acyl-CoA-binding domain-containing protein 5 OS=Homo sapiens OX=9606 GN=ACBD5,0,65.677,28,12,50,12,525,58.9,5.26,17234,12.72,11,1,cell communication;cell organization and biogenesis;metabolic process;response to stimulus;transport,membrane;nucleus,,Pf00887,91452,ENSG00000107897.18,ACBD5,10,,,,0,High,1
P07093-3,Isoform 3 of Glia-derived nexin OS=Homo sapiens OX=9606 GN=SERPINE2,0,65.578,37,12,65,11,409,45.2,9.22,22673,0,12,1,cell organization and biogenesis;coagulation;regulation of biological process;response to stimulus;transport,cytosol;extracellular,enzyme regulator activity;protein binding,Pf00079,5270,ENSG00000135919.12,SERPINE2,2,,,,0,High,1
Q9NQT8,Kinesin-like protein KIF13B OS=Homo sapiens OX=9606 GN=KIF13B PE=1 SV=2,0,65.577,8,12,61,6,1826,202.7,5.88,24625,,12,,cellular component movement;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol,catalytic activity;motor activity;nucleotide binding;protein binding,"Pf00225, Pf00498, Pf01302, Pf12423, Pf12473",23303,ENSG00000197892.12,KIF13B,8,,,COPI-dependent Golgi-to-ER retrograde traffic; Kinesins,8,High,1
Q15036,Sorting nexin-17 OS=Homo sapiens OX=9606 GN=SNX17 PE=1 SV=1,0,65.567,28,9,37,9,470,52.9,7.46,17855,,9,,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;Golgi;membrane,protein binding,Pf00787,9784,ENSG00000115234.10,SNX17,2,,,,0,High,1
Q5JVF3,PCI domain-containing protein 2 OS=Homo sapiens OX=9606 GN=PCID2 PE=1 SV=2,0,65.552,30,10,68,10,399,46,8.53,28453,,10,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,,DNA binding;protein binding;RNA binding,Pf01399,55795,ENSG00000126226.21,PCID2,13,,,,0,High,1
P56378,"ATP synthase subunit ATP5MPL, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5MPL PE=1 SV=1",0,65.532,33,8,739,8,58,6.7,10.08,371120,7.34,8,2,,membrane;mitochondrion,,Pf08039,9556,ENSG00000156411.9,C14orf2,14,,,,0,High,1
Q9NZL4,Hsp70-binding protein 1 OS=Homo sapiens OX=9606 GN=HSPBP1 PE=1 SV=2,0,65.49,26,9,85,9,359,39.3,5.21,38140,0,9,1,,,,,,,,,,,,0,High,1
P62750,60S ribosomal protein L23a OS=Homo sapiens OX=9606 GN=RPL23A PE=1 SV=1,0,65.408,33,9,195,9,156,17.7,10.45,87877,0,9,1,cell organization and biogenesis;cell proliferation;metabolic process;transport,cytoplasm;cytosol;nucleus;ribosome,protein binding;RNA binding;structural molecule activity,"Pf00276, Pf03939",6147,ENSG00000198242.13,RPL23A,17,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
P13489,Ribonuclease inhibitor OS=Homo sapiens OX=9606 GN=RNH1 PE=1 SV=2,0,65.397,20,9,152,9,461,49.9,4.82,84374,7.36,7,2,metabolic process;regulation of biological process,cytoplasm;cytosol,enzyme regulator activity;protein binding,,6050,ENSG00000276230.4; ENSG00000023191.16,RNH1,11; CHR_HSCHR11_1_CTG8,,,,0,High,1
O95376,E3 ubiquitin-protein ligase ARIH2 OS=Homo sapiens OX=9606 GN=ARIH2 PE=1 SV=1,0,65.343,24,9,49,9,493,57.8,5.63,19087,4.81,9,2,cell growth;cell proliferation;development;metabolic process;regulation of biological process,cytoplasm;nucleus,catalytic activity;metal ion binding;protein binding,Pf01485,10425,ENSG00000177479.19,ARIH2,3,,,Antigen processing: Ubiquitination & Proteasome degradation,4,High,1
Q6YHK3,CD109 antigen OS=Homo sapiens OX=9606 GN=CD109 PE=1 SV=2,0,65.308,13,13,62,13,1445,161.6,5.85,23826,,13,,metabolic process;regulation of biological process;transport,cell surface;extracellular;membrane,enzyme regulator activity;protein binding,"Pf00207, Pf01835, Pf07677, Pf07678, Pf07703, Pf10569, Pf11974, Pf13249",135228,ENSG00000156535.13,CD109,6,,,Platelet degranulation ; Post-translational modification: synthesis of GPI-anchored proteins,7,High,1
Q9Y2C4,"Nuclease EXOG, mitochondrial OS=Homo sapiens OX=9606 GN=EXOG PE=1 SV=2",0,65.283,35,8,76,8,368,41.1,8.27,35402,7.19,7,1,metabolic process,membrane;mitochondrion,catalytic activity;metal ion binding,Pf01223,9941,ENSG00000157036.12,EXOG,3,,,,0,High,1
O43813,Glutathione S-transferase LANCL1 OS=Homo sapiens OX=9606 GN=LANCL1 PE=1 SV=1,0,65.184,17,7,172,7,399,45.3,7.75,82298,0,7,2,regulation of biological process;response to stimulus,cytoplasm;membrane,metal ion binding;protein binding;receptor activity;signal transducer activity,Pf05147,10314,ENSG00000115365.11,LANCL1,2,,,,0,High,1
P42166,"Lamina-associated polypeptide 2, isoform alpha OS=Homo sapiens OX=9606 GN=TMPO PE=1 SV=2",0,65.16,17,8,64,1,694,75.4,7.66,32691,,8,,regulation of biological process,chromosome;nucleus,DNA binding;protein binding,"Pf03020, Pf08198, Pf11560",7112,ENSG00000120802.13,TMPO,12,,,,0,High,1
Q99471,Prefoldin subunit 5 OS=Homo sapiens OX=9606 GN=PFDN5 PE=1 SV=2,0,65.108,55,6,118,6,154,17.3,6.33,57641,0,6,1,metabolic process;regulation of biological process,cytoplasm;nucleus,protein binding,Pf02996,5204,ENSG00000123349.13,PFDN5,12,,,Prefoldin mediated transfer of substrate  to CCT/TriC,5,High,1
Q0VDG4,Secernin-3 OS=Homo sapiens OX=9606 GN=SCRN3 PE=1 SV=1,0,65.104,30,10,59,10,424,48.5,5.55,23050,24.42,9,1,metabolic process;transport,,catalytic activity,Pf03577,79634,ENSG00000144306.14,SCRN3,2,,,,0,High,1
Q8WTS6,Histone-lysine N-methyltransferase SETD7 OS=Homo sapiens OX=9606 GN=SETD7 PE=1 SV=1,0,65.078,34,8,61,8,366,40.7,4.63,22205,0,8,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;nucleus,catalytic activity;protein binding,Pf00856,80854,ENSG00000145391.13,SETD7,4,Lysine degradation; FoxO signaling pathway,Histone Modifications,PKMTs methylate histone lysines,6,High,1
P24534,Elongation factor 1-beta OS=Homo sapiens OX=9606 GN=EEF1B2 PE=1 SV=3,0,64.954,52,8,151,7,225,24.7,4.67,68475,11.53,6,3,metabolic process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;nucleus,protein binding;RNA binding,"Pf00736, Pf14497",1933,ENSG00000283391.1; ENSG00000114942.13,EEF1B2,2; CHR_HSCHR2_6_CTG7_2,,Translation Factors,Eukaryotic Translation Elongation,4,High,1
Q14524-2,Isoform 2 of Sodium channel protein type 5 subunit alpha OS=Homo sapiens OX=9606 GN=SCN5A,0,64.952,8,11,43,10,2015,226.7,5.49,6182,76.8,3,8,cell communication;regulation of biological process;response to stimulus;transport,cell surface;endoplasmic reticulum;membrane,protein binding;transporter activity,"Pf00520, Pf06512, Pf08016, Pf11933",6331,ENSG00000183873.15,SCN5A,3,,Cardiac Progenitor Differentiation; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,,2,High,1
Q9NRR5,Ubiquilin-4 OS=Homo sapiens OX=9606 GN=UBQLN4 PE=1 SV=2,0,64.944,17,8,56,4,601,63.8,5.22,27299,,8,,metabolic process;regulation of biological process,cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;proteasome;vacuole,protein binding,"Pf00240, Pf00627, Pf11976",56893,ENSG00000160803.7,UBQLN4,1,Protein processing in endoplasmic reticulum,,,1,High,1
Q7Z3C6,Autophagy-related protein 9A OS=Homo sapiens OX=9606 GN=ATG9A PE=1 SV=3,0,64.861,18,12,31,12,839,94.4,6.67,13270,2.54,12,1,cell organization and biogenesis;metabolic process;response to stimulus;transport,endoplasmic reticulum;endosome;Golgi;membrane;vacuole,protein binding,Pf04109,79065,ENSG00000198925.10,ATG9A,2,,,Macroautophagy,2,High,1
Q9H019,Mitochondrial fission regulator 1-like OS=Homo sapiens OX=9606 GN=MTFR1L PE=1 SV=2,0,64.828,36,10,189,10,292,31.9,6.1,77329,,10,,cell organization and biogenesis;metabolic process,mitochondrion,protein binding,Pf05308,56181,ENSG00000117640.17,FAM54B; MTFR1L,1,,,,0,High,1
Q5T013,Putative hydroxypyruvate isomerase OS=Homo sapiens OX=9606 GN=HYI PE=1 SV=2,0,64.767,52,10,39,10,277,30.4,5.5,15308,,10,,,,catalytic activity;protein binding,Pf01261,81888,ENSG00000178922.16,HYI,1,Glyoxylate and dicarboxylate metabolism; Metabolic pathways,,,2,High,1
Q96QE5,"Transcription elongation factor, mitochondrial OS=Homo sapiens OX=9606 GN=TEFM PE=1 SV=1",0,64.752,36,11,80,11,360,41.7,9.32,34883,0,11,1,cell organization and biogenesis;metabolic process;regulation of biological process,mitochondrion;organelle lumen,catalytic activity;enzyme regulator activity;protein binding;RNA binding,Pf12836,79736,ENSG00000172171.10,TEFM,17,,,,0,High,1
P05787,"Keratin, type II cytoskeletal 8 OS=Homo sapiens OX=9606 GN=KRT8 PE=1 SV=7",0,64.731,19,13,394,6,483,53.7,5.59,194526,,13,,cell death;cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,catalytic activity;motor activity;protein binding;structural molecule activity,"Pf00038, Pf01576, Pf13166, Pf15003",3856,ENSG00000170421.12,KRT8,12,,Primary Focal Segmental Glomerulosclerosis FSGS,Formation of the cornified envelope,4,High,1
Q969N2,GPI transamidase component PIG-T OS=Homo sapiens OX=9606 GN=PIGT PE=1 SV=1,0,64.679,22,11,75,11,578,65.7,8.38,28350,0,11,1,cell death;cell differentiation;metabolic process,cytoplasm;endoplasmic reticulum;membrane,catalytic activity;protein binding,Pf04113,51604,ENSG00000124155.17,PIGT,20,Metabolic pathways; Glycosylphosphatidylinositol (GPI)-anchor biosynthesis,,Attachment of GPI anchor to uPAR,6,High,1
Q9Y646,Carboxypeptidase Q OS=Homo sapiens OX=9606 GN=CPQ PE=1 SV=1,0,64.673,31,11,78,11,472,51.9,6.18,34442,,11,,metabolic process,cytoplasm;endoplasmic reticulum;extracellular;Golgi;vacuole,catalytic activity;metal ion binding;protein binding,Pf04389,10404,ENSG00000104324.15,CPQ,8,,,,0,High,1
O94919,Endonuclease domain-containing 1 protein OS=Homo sapiens OX=9606 GN=ENDOD1 PE=1 SV=2,0,64.664,21,8,63,8,500,55,5.71,27546,,8,,metabolic process;transport,cytosol;extracellular;membrane,catalytic activity;metal ion binding,Pf01223,23052,ENSG00000149218.4,ENDOD1,11,,,Platelet degranulation,4,High,1
Q9BVS5,"tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=TRMT61B PE=1 SV=2",0,64.637,32,10,51,10,477,52.9,6.62,23842,,10,,cell organization and biogenesis;metabolic process,mitochondrion;organelle lumen,catalytic activity;protein binding,Pf08704,55006,ENSG00000171103.10,TRMT61B,2,,,tRNA modification in the mitochondrion,3,High,1
O43432,Eukaryotic translation initiation factor 4 gamma 3 OS=Homo sapiens OX=9606 GN=EIF4G3 PE=1 SV=2,0,64.612,12,17,68,15,1585,176.5,5.38,33361,,17,,metabolic process;regulation of biological process,cytosol,protein binding;RNA binding,"Pf02020, Pf02847, Pf02854",8672,ENSG00000075151.20,EIF4G3,1,Viral myocarditis; RNA transport,Translation Factors,ISG15 antiviral mechanism,8,High,1
P02656,Apolipoprotein C-III OS=Homo sapiens OX=9606 GN=APOC3 PE=1 SV=1,0,64.601,52,7,102,7,99,10.8,5.41,47221,0,7,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,endosome;extracellular,enzyme regulator activity;protein binding,Pf05778,345,ENSG00000110245.11,APOC3,11,PPAR signaling pathway,PPAR Alpha Pathway; PPAR signaling pathway; Statin Pathway,Signaling by GPCR; HDL remodeling; Retinoid metabolism and transport; Chylomicron assembly; Chylomicron remodeling,18,High,1
Q9BYD2,"39S ribosomal protein L9, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL9 PE=1 SV=2",0,64.593,31,8,95,8,267,30.2,10.08,39943,,8,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,protein binding;RNA binding;structural molecule activity,Pf01281,65005,ENSG00000143436.10,MRPL9,1,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
Q96DH6,RNA-binding protein Musashi homolog 2 OS=Homo sapiens OX=9606 GN=MSI2 PE=1 SV=1,0,64.59,28,8,73,8,328,35.2,8.48,33478,0,8,1,,cytoplasm,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",124540,ENSG00000153944.10,MSI2,17,mRNA surveillance pathway,,,1,High,1
P82663,"28S ribosomal protein S25, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS25 PE=1 SV=1",0,64.558,42,6,163,6,173,20.1,8.82,85929,,6,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,structural molecule activity,Pf05047,64432,ENSG00000131368.7,MRPS25,3,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
P29590,Protein PML OS=Homo sapiens OX=9606 GN=PML PE=1 SV=3,0,64.543,15,13,42,13,882,97.5,6.21,18232,,13,,cell death;cell differentiation;cell organization and biogenesis;cellular component movement;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;endosome;membrane;nucleus,DNA binding;metal ion binding;protein binding,"Pf00097, Pf00643, Pf12126, Pf13639, Pf13920, Pf14634, Pf14835",5371,ENSG00000140464.19,PML,15,Influenza A; Acute myeloid leukemia; Transcriptional misregulation in cancer; Endocytosis; Herpes simplex infection; Pathways in cancer; Ubiquitin mediated proteolysis,miRNA Regulation of DNA Damage Response; Wnt/beta-catenin Signaling Pathway in Leukemia; TGF-beta Signaling Pathway; DNA Damage Response,Interferon gamma signaling; Regulation of TP53 Activity through Acetylation; Regulation of RUNX1 Expression and Activity; SUMOylation of DNA damage response and repair proteins; Regulation of PTEN localization,33,High,1
A0A075B6S5,Immunoglobulin kappa variable 1-27 OS=Homo sapiens OX=9606 GN=IGKV1-27 PE=3 SV=1,0,64.472,42,7,98,1,117,12.7,8.29,49225,,7,,response to stimulus,extracellular;membrane,,"Pf00047, Pf07679, Pf07686, Pf13927",28935,ENSG00000282666.1; ENSG00000244575.3,IGKV1-27,CHR_HG2290_PATCH; 2,,,,0,High,1
O14908,PDZ domain-containing protein GIPC1 OS=Homo sapiens OX=9606 GN=GIPC1 PE=1 SV=2,0,64.438,43,10,61,9,333,36,6.28,24090,0,10,1,cell communication;cellular component movement;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane,protein binding,Pf00595,10755,ENSG00000123159.15,GIPC1,19,,VEGFA-VEGFR2 Signaling Pathway,,1,High,1
Q9H2J4,Phosducin-like protein 3 OS=Homo sapiens OX=9606 GN=PDCL3 PE=1 SV=1,0,64.438,43,10,63,10,239,27.6,4.84,29894,,10,,cell death;metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,Pf02114,79031,ENSG00000115539.13,PDCL3,2,,,,0,High,1
Q15836,Vesicle-associated membrane protein 3 OS=Homo sapiens OX=9606 GN=VAMP3 PE=1 SV=3,0,64.409,52,4,58,2,100,11.3,8.79,25812,,4,,cell organization and biogenesis;regulation of biological process;transport,cell surface;cytosol;endosome;membrane,protein binding,Pf00957,9341,ENSG00000049245.12,VAMP3,1,Phagosome; SNARE interactions in vesicular transport,,Cargo recognition for clathrin-mediated endocytosis; ER-Phagosome pathway; Retrograde transport at the Trans-Golgi-Network,13,High,1
P84098,60S ribosomal protein L19 OS=Homo sapiens OX=9606 GN=RPL19 PE=1 SV=1,0,64.32,22,5,229,5,196,23.5,11.47,98696,0,5,1,cell organization and biogenesis;metabolic process;transport,cytosol;membrane;ribosome,protein binding;RNA binding;structural molecule activity,Pf01280,6143,ENSG00000108298.9,RPL19,17,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
Q9NZJ9,Diphosphoinositol polyphosphate phosphohydrolase 2 OS=Homo sapiens OX=9606 GN=NUDT4 PE=1 SV=2,0,64.312,39,6,77,6,180,20.3,6.35,35544,,6,,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;protein binding;RNA binding,Pf00293,11163,ENSG00000173598.13,NUDT4,12,,,Synthesis of pyrophosphates in the cytosol,3,High,1
Q9UK41,Vacuolar protein sorting-associated protein 28 homolog OS=Homo sapiens OX=9606 GN=VPS28 PE=1 SV=1,0,64.276,39,5,63,5,221,25.4,5.54,27992,1.71,5,1,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane,protein binding,Pf03997,51160,ENSG00000160948.13,VPS28,8,Endocytosis,,Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); Membrane binding and targetting of GAG proteins,13,High,1
Q8IWE2,Protein NOXP20 OS=Homo sapiens OX=9606 GN=FAM114A1 PE=1 SV=2,0,64.225,23,8,40,8,563,60.7,4.68,17461,0,8,1,,cytoplasm;cytosol;Golgi;nucleus,protein binding,Pf05334,92689,ENSG00000197712.11,FAM114A1,4,,,,0,High,1
P10321,"HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=3",0,64.195,24,7,60,2,366,40.6,6.04,30375,0,7,1,regulation of biological process;response to stimulus;transport,cell surface;endoplasmic reticulum;Golgi;membrane,protein binding,"Pf00129, Pf07654",3107,ENSG00000204525.16,HLA-C,6,Allograft rejection; Antigen processing and presentation; Herpes simplex infection; HTLV-I infection; Type I diabetes mellitus; Endocytosis; Graft-versus-host disease; Autoimmune thyroid disease; Natural killer cell mediated cytotoxicity; Epstein-Barr virus infection; Viral carcinogenesis; Viral myocarditis; Phagosome; Cell adhesion molecules (CAMs),Proteasome Degradation; Allograft Rejection,"Interferon alpha/beta signaling; ER-Phagosome pathway; Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Endosomal/Vacuolar pathway; Interferon gamma signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC",30,High,1
O60493,Sorting nexin-3 OS=Homo sapiens OX=9606 GN=SNX3 PE=1 SV=3,0,64.007,49,12,225,10,162,18.8,8.66,104688,0,11,2,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane,protein binding,Pf00787,8724,ENSG00000112335.14,SNX3,6,Endocytosis,,WNT ligand biogenesis and trafficking; Ub-specific processing proteases,8,High,1
P61586,Transforming protein RhoA OS=Homo sapiens OX=9606 GN=RHOA PE=1 SV=1,0,63.973,46,9,167,7,193,21.8,6.1,71436,11.02,7,2,cell differentiation;cell division;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endosome;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf08477",387,ENSG00000067560.10,RHOA,3,MicroRNAs in cancer; Pancreatic secretion; Chemokine signaling pathway; Tight junction; Pathways in cancer; Sphingolipid signaling pathway; TGF-beta signaling pathway; Rap1 signaling pathway; Adherens junction; Phospholipase D signaling pathway; Focal adhesion; cAMP signaling pathway; Vascular smooth muscle contraction; Pertussis; Ras signaling pathway; T cell receptor signaling pathway; Colorectal cancer; Leukocyte transendothelial migration; Viral carcinogenesis; Neurotrophin signaling pathway; mTOR signaling pathway; Platelet activation; Wnt signaling pathway; Tuberculosis; Oxytocin signaling pathway; cGMP-PKG signaling pathway; Pathogenic Escherichia coli infection; NOD-like receptor signaling pathway; Endocytosis; Axon guidance; Bacterial invasion of epithelial cells; Regulation of actin cytoskeleton; Proteoglycans in cancer,Androgen receptor signaling pathway; Physiological and Pathological Hypertrophy  of the Heart; MicroRNAs in cardiomyocyte hypertrophy; Leptin signaling pathway; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Spinal Cord Injury; Alpha 6 Beta 4 signaling pathway; Focal Adhesion; G Protein Signaling Pathways; Wnt Signaling Pathway Netpath; Hypothetical Craniofacial Development Pathway; TGF-beta Signaling Pathway; Association Between Physico-Chemical Features and Toxicity Associated Pathways; VEGFA-VEGFR2 Signaling Pathway; Wnt Signaling Pathway and Pluripotency; Wnt Signaling Pathway; Regulation of Actin Cytoskeleton; G13 Signaling Pathway; DNA Damage Response (only ATM dependent),"Rho GTPase cycle; Ovarian tumor domain proteases; G beta:gamma signalling through PI3Kgamma; RHO GTPases activate CIT; PCP/CE pathway; PI3K/AKT activation; SLIT2:ROBO1 increases RHOA activity; EPHA-mediated growth cone collapse; EPHB-mediated forward signaling; ERBB2 Regulates Cell Motility; Neutrophil degranulation; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); Sema4D induced cell migration and growth-cone collapse; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; G alpha (12/13) signalling events; RHO GTPases activate KTN1; VEGFA-VEGFR2 Pathway; RHO GTPases Activate ROCKs; GPVI-mediated activation cascade; Sema4D mediated inhibition of cell attachment and migration; RHO GTPases Activate Formins; Axonal growth inhibition (RHOA activation); RHO GTPases activate PKNs; RHO GTPases Activate Rhotekin and Rhophilins; Axonal growth stimulation",111,High,1
Q58WW2-3,Isoform 3 of DDB1- and CUL4-associated factor 6 OS=Homo sapiens OX=9606 GN=DCAF6,0,63.943,19,15,52,15,951,106.5,5.41,15974,6.16,13,2,metabolic process;regulation of biological process,cytosol;nucleus,protein binding,Pf00400,55827,ENSG00000143164.15,DCAF6,1,,,,0,High,1
P31689,DnaJ homolog subfamily A member 1 OS=Homo sapiens OX=9606 GN=DNAJA1 PE=1 SV=2,0,63.815,28,9,116,9,397,44.8,7.08,46848,,9,,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;mitochondrion;nucleus,enzyme regulator activity;metal ion binding;nucleotide binding;protein binding,"Pf00226, Pf00684, Pf01556",3301,ENSG00000086061.15,DNAJA1,9,Protein processing in endoplasmic reticulum,Exercise-induced Circadian Regulation,HSP90 chaperone cycle for steroid hormone receptors (SHR),5,High,1
Q6P1N9,Putative deoxyribonuclease TATDN1 OS=Homo sapiens OX=9606 GN=TATDN1 PE=1 SV=2,0,63.767,31,8,88,8,297,33.6,6.96,45052,,8,,metabolic process,nucleus,catalytic activity;metal ion binding;protein binding,Pf01026,83940,ENSG00000147687.18,TATDN1,8,,,,0,High,1
O75531,Barrier-to-autointegration factor OS=Homo sapiens OX=9606 GN=BANF1 PE=1 SV=1,0,63.709,55,7,134,7,89,10.1,6.09,61623,,7,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,chromosome;cytoplasm;cytosol;nucleus,DNA binding;protein binding,Pf02961,8815,ENSG00000175334.7,BANF1,11,,,2-LTR circle formation; APOBEC3G mediated resistance to HIV-1 infection; Integration of viral DNA into host genomic DNA; Vpr-mediated nuclear import of PICs; Autointegration results in viral DNA circles; Initiation of Nuclear Envelope Reformation; Clearance of Nuclear Envelope Membranes from Chromatin,23,High,1
Q9NY15,Stabilin-1 OS=Homo sapiens OX=9606 GN=STAB1 PE=1 SV=3,0,63.703,7,14,56,14,2570,275.3,6.49,22957,,14,,cell communication;defense response;metabolic process;regulation of biological process;response to stimulus;transport,membrane,catalytic activity;metal ion binding;protein binding;receptor activity,"Pf00193, Pf02469, Pf12947",23166,ENSG00000010327.10,STAB1,3,,,Scavenging by Class H Receptors,3,High,1
Q92526,T-complex protein 1 subunit zeta-2 OS=Homo sapiens OX=9606 GN=CCT6B PE=1 SV=5,0,63.682,16,9,186,1,530,57.8,7.24,81244,0,9,1,cell organization and biogenesis;metabolic process;transport,cytoplasm;cytosol;membrane,nucleotide binding;protein binding;transporter activity,"Pf00118, Pf05504",10693,ENSG00000132141.13,CCT6B,17,,,Prefoldin mediated transfer of substrate  to CCT/TriC; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Association of TriC/CCT with target proteins during biosynthesis; Formation of tubulin folding intermediates by CCT/TriC; Folding of actin by CCT/TriC,9,High,1
Q9NVS2,"39S ribosomal protein S18a, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS18A PE=1 SV=1",0,63.679,36,8,95,8,196,22.2,10.33,40806,11.19,8,1,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,structural molecule activity,Pf01084,55168,ENSG00000096080.11,MRPS18A,6,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
Q12765,Secernin-1 OS=Homo sapiens OX=9606 GN=SCRN1 PE=1 SV=2,0,63.523,22,7,62,7,414,46.4,4.75,31465,,7,,metabolic process;transport,cytoplasm;membrane;nucleus,catalytic activity;protein binding,Pf03577,9805,ENSG00000136193.16,SCRN1,7,,,,0,High,1
P36269,Glutathione hydrolase 5 proenzyme OS=Homo sapiens OX=9606 GN=GGT5 PE=1 SV=2,0,63.499,16,8,94,8,586,62.2,7.55,42507,0,8,1,defense response;metabolic process;response to stimulus,membrane,catalytic activity,Pf01019,2687,ENSG00000099998.17,GGT5,22,Glutathione metabolism; Taurine and hypotaurine metabolism; Metabolic pathways; Arachidonic acid metabolism,Glutathione metabolism,Glutathione synthesis and recycling; Synthesis of Leukotrienes (LT) and Eoxins (EX); Aflatoxin activation and detoxification,15,High,1
Q96NA2,Rab-interacting lysosomal protein OS=Homo sapiens OX=9606 GN=RILP PE=1 SV=1,0,63.475,24,11,82,11,401,44.2,5.59,34527,5.64,11,3,cell organization and biogenesis;regulation of biological process;transport,cytosol;endosome;membrane;mitochondrion;vacuole,protein binding,"Pf09744, Pf11461",83547,ENSG00000274145.2; ENSG00000167705.11,RILP,17; CHR_HSCHR17_1_CTG2,Phagosome; Salmonella infection,,MHC class II antigen presentation,5,High,1
Q15848,Adiponectin OS=Homo sapiens OX=9606 GN=ADIPOQ PE=1 SV=1,0,63.328,30,4,224,4,244,26.4,5.74,117096,0,4,1,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cell surface;endoplasmic reticulum;extracellular,protein binding,"Pf00386, Pf01391",9370,ENSG00000181092.9,ADIPOQ,3,Adipocytokine signaling pathway; Type II diabetes mellitus; Non-alcoholic fatty liver disease (NAFLD); PPAR signaling pathway; Longevity regulating pathway; AMPK signaling pathway,AMP-activated Protein Kinase (AMPK) Signaling; Type II diabetes mellitus; Adipogenesis; Differentiation of white and brown adipocyte; Transcription factor regulation in adipogenesis; Leptin and adiponectin; PPAR signaling pathway,Transcriptional regulation of white adipocyte differentiation; AMPK inhibits chREBP transcriptional activation activity,18,High,1
Q12792,Twinfilin-1 OS=Homo sapiens OX=9606 GN=TWF1 PE=1 SV=3,0,63.32,25,8,57,6,350,40.3,6.96,25468,,8,,cell organization and biogenesis;regulation of biological process,cytoplasm;cytoskeleton;cytosol,catalytic activity;nucleotide binding;protein binding,Pf00241,5756,ENSG00000151239.13,TWF1,12,,,,0,High,1
Q96FV2,Secernin-2 OS=Homo sapiens OX=9606 GN=SCRN2 PE=1 SV=3,0,63.319,19,5,44,5,425,46.6,5.67,21397,,5,,metabolic process;transport,,catalytic activity;protein binding,Pf03577,90507,ENSG00000141295.13,SCRN2,17,,,,0,High,1
Q9H444,Charged multivesicular body protein 4b OS=Homo sapiens OX=9606 GN=CHMP4B PE=1 SV=1,0,63.159,39,8,68,8,224,24.9,4.82,31873,,8,,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane;nucleus,protein binding,Pf03357,128866,ENSG00000101421.3,CHMP4B,20,Endocytosis,,Budding and maturation of HIV virion; Macroautophagy; Endosomal Sorting Complex Required For Transport (ESCRT),12,High,1
O96019,Actin-like protein 6A OS=Homo sapiens OX=9606 GN=ACTL6A PE=1 SV=1,0,63.124,38,11,72,10,429,47.4,5.6,26780,,11,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,membrane;nucleus,DNA binding;protein binding,Pf00022,86,ENSG00000136518.16,ACTL6A,3,,Gastric Cancer Network 1,RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; UCH proteinases; DNA Damage Recognition in GG-NER; RMTs methylate histone arginines; HATs acetylate histones,18,High,1
Q9UMY4-1,Isoform 1 of Sorting nexin-12 OS=Homo sapiens OX=9606 GN=SNX12,0,63.092,59,10,162,8,172,19.7,7.87,64000,0,10,1,cell organization and biogenesis;regulation of biological process;transport,endosome;membrane,protein binding,Pf00787,29934,,SNX12,X,Endocytosis,,,1,High,1
Q9NYF8,Bcl-2-associated transcription factor 1 OS=Homo sapiens OX=9606 GN=BCLAF1 PE=1 SV=2,0,62.946,17,10,80,9,920,106.1,9.98,31418,,10,,cell death;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,DNA binding;protein binding;RNA binding,Pf15440,9774,ENSG00000029363.16,BCLAF1,6,,Interactome of polycomb repressive complex 2 (PRC2),,1,High,1
Q9Y295,Developmentally-regulated GTP-binding protein 1 OS=Homo sapiens OX=9606 GN=DRG1 PE=1 SV=1,0,62.909,34,11,116,10,367,40.5,8.9,47945,,11,,development;metabolic process,cytoplasm;cytosol;membrane,nucleotide binding;protein binding,"Pf00009, Pf01926, Pf02421, Pf02824",4733,ENSG00000185721.12,DRG1,22,,,,0,High,1
Q96AQ8,Mitochondrial calcium uniporter regulator 1 OS=Homo sapiens OX=9606 GN=MCUR1 PE=1 SV=1,0,62.891,23,9,54,9,359,39.7,9.63,26048,,9,,cellular homeostasis;transport,membrane;mitochondrion,protein binding,Pf07798,63933,ENSG00000050393.11,CCDC90A; MCUR1,6,,,,0,High,1
P61758,Prefoldin subunit 3 OS=Homo sapiens OX=9606 GN=VBP1 PE=1 SV=4,0,62.843,38,8,129,8,197,22.6,7.11,61169,0,8,1,cell organization and biogenesis;metabolic process,cytoplasm;cytosol;nucleus,protein binding,Pf02996,7411,ENSG00000155959.10,VBP1,X,,,,0,High,1
Q13508,Ecto-ADP-ribosyltransferase 3 OS=Homo sapiens OX=9606 GN=ART3 PE=1 SV=2,0,62.831,26,9,76,9,389,43.9,6.06,35646,,9,,metabolic process,extracellular;membrane,catalytic activity,Pf01129,419,ENSG00000156219.16,ART3,4,,,Post-translational modification: synthesis of GPI-anchored proteins,3,High,1
P46977,Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A OS=Homo sapiens OX=9606 GN=STT3A PE=1 SV=2,0,62.817,15,12,110,10,705,80.5,8.07,47291,,12,,metabolic process,endoplasmic reticulum;membrane,catalytic activity;metal ion binding;protein binding,Pf02516,3703,ENSG00000134910.12,STT3A,11,Metabolic pathways; N-Glycan biosynthesis; Protein processing in endoplasmic reticulum,,Asparagine N-linked glycosylation,6,High,1
P07741,Adenine phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=APRT PE=1 SV=2,0,62.759,43,8,129,7,180,19.6,6.02,67085,,8,,metabolic process;response to stimulus;transport,cytoplasm;cytosol;extracellular;organelle lumen,catalytic activity;nucleotide binding,Pf00156,353,ENSG00000198931.10,APRT,16,Metabolic pathways; Purine metabolism,,Neutrophil degranulation; Purine salvage,9,High,1
Q8N983,"39S ribosomal protein L43, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL43 PE=1 SV=1",0,62.75,39,10,106,10,215,23.4,8.65,50322,,10,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,protein binding;RNA binding;structural molecule activity,Pf05047,84545,ENSG00000055950.16,MRPL43,10,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
P25686,DnaJ homolog subfamily B member 2 OS=Homo sapiens OX=9606 GN=DNAJB2 PE=1 SV=3,0,62.688,34,9,76,8,324,35.6,5.95,37579,,9,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;proteasome,enzyme regulator activity;protein binding,Pf00226,3300,ENSG00000135924.15,DNAJB2,2,Protein processing in endoplasmic reticulum,,,1,High,1
Q13405,"39S ribosomal protein L49, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL49 PE=1 SV=1",0,62.681,61,10,71,10,166,19.2,9.45,35653,,10,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,protein binding;structural molecule activity,Pf05046,740,ENSG00000149792.8,MRPL49,11,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
P36543,V-type proton ATPase subunit E 1 OS=Homo sapiens OX=9606 GN=ATP6V1E1 PE=1 SV=1,0,62.672,32,8,92,8,226,26.1,8,42914,2.97,8,1,cellular homeostasis;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane;mitochondrion,catalytic activity;protein binding;transporter activity,Pf01991,529,ENSG00000131100.12,ATP6V1E1,22,Phagosome; Synaptic vesicle cycle; Metabolic pathways; mTOR signaling pathway; Collecting duct acid secretion; Vibrio cholerae infection; Rheumatoid arthritis; Epithelial cell signaling in Helicobacter pylori infection; Oxidative phosphorylation,,"Transferrin endocytosis and recycling; ROS, RNS production in phagocytes; Ion channel transport; Insulin receptor recycling",20,High,1
O95881,Thioredoxin domain-containing protein 12 OS=Homo sapiens OX=9606 GN=TXNDC12 PE=1 SV=1,0,62.671,37,7,129,7,172,19.2,5.4,57720,0,7,1,cell differentiation;cellular homeostasis;metabolic process;regulation of biological process,endoplasmic reticulum;organelle lumen,catalytic activity;protein binding,"Pf00085, Pf13098, Pf13899",51060,ENSG00000117862.11,TXNDC12,1,Glutathione metabolism,,,1,High,1
P04049,RAF proto-oncogene serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=1,0,62.591,29,13,65,9,648,73,9.2,26597,,13,,cell death;cell differentiation;cell organization and biogenesis;cell proliferation;cellular homeostasis;development;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;Golgi;membrane;mitochondrion;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf00130, Pf02196, Pf07714, Pf14531",5894,ENSG00000132155.11,RAF1,3,Estrogen signaling pathway; FoxO signaling pathway; Rap1 signaling pathway; Prostate cancer; Focal adhesion; Hepatitis C; Insulin signaling pathway; B cell receptor signaling pathway; Natural killer cell mediated cytotoxicity; EGFR tyrosine kinase inhibitor resistance; Sphingolipid signaling pathway; Signaling pathways regulating pluripotency of stem cells; T cell receptor signaling pathway; cGMP-PKG signaling pathway; Endometrial cancer; Renal cell carcinoma; mTOR signaling pathway; GnRH signaling pathway; Prolactin signaling pathway; Progesterone-mediated oocyte maturation; Thyroid hormone signaling pathway; Jak-STAT signaling pathway; Ras signaling pathway; Influenza A; Central carbon metabolism in cancer; Acute myeloid leukemia; Pathways in cancer; Apoptosis; Fc epsilon RI signaling pathway; Vascular smooth muscle contraction; Neurotrophin signaling pathway; Colorectal cancer; Tuberculosis; Regulation of actin cytoskeleton; Axon guidance; Phospholipase D signaling pathway; Oxytocin signaling pathway; Glioma; Choline metabolism in cancer; Endocrine resistance; Non-small cell lung cancer; Alcoholism; VEGF signaling pathway; Bladder cancer; Chronic myeloid leukemia; Long-term depression; MicroRNAs in cancer; Proteoglycans in cancer; Pancreatic cancer; Melanogenesis; Hepatitis B; Melanoma; Serotonergic synapse; Gap junction; PI3K-Akt signaling pathway; Long-term potentiation; ErbB signaling pathway; cAMP signaling pathway; Breast cancer; Chemokine signaling pathway; MAPK signaling pathway; Fc gamma R-mediated phagocytosis,"IL-5 Signaling Pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated Cell Adhesion; Human Thyroid Stimulating Hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle Stimulating Hormone (FSH) signaling pathway; TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway; Prolactin Signaling Pathway; Endothelin Pathways; Signaling Pathways in Glioblastoma; B Cell Receptor Signaling Pathway; TNF alpha Signaling Pathway; AGE/RAGE pathway; Interleukin-11 Signaling Pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Retinoblastoma (RB) in Cancer; Aryl Hydrocarbon Receptor; Common Pathways Underlying Drug Addiction; Cardiac Hypertrophic Response; IL-3 Signaling Pathway; Extracellular vesicle-mediated signaling in recipient cells; Kit receptor signaling pathway; Focal Adhesion; Signaling of Hepatocyte Growth Factor Receptor; Pathways Affected in Adenoid Cystic Carcinoma; TGF-beta Signaling Pathway; Association Between Physico-Chemical Features and Toxicity Associated Pathways; MAPK Signaling Pathway; MAPK  and NFkB Signalling Pathways Inhibited by Yersinia YopJ; ERK Pathway in Huntington's Disease; T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; Chemokine signaling pathway; ESC Pluripotency Pathways; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; MAPK Cascade; EGF/EGFR Signaling Pathway; Insulin Signaling; IL-2 Signaling Pathway; Regulation of Actin Cytoskeleton; EPO Receptor Signaling; Senescence and Autophagy in Cancer; T-Cell antigen Receptor (TCR)  Signaling Pathway; Serotonin Receptor 2 and ELK-SRF/GATA4 signaling",Signaling by BRAF and RAF fusions; MAP2K and MAPK activation; Signaling by RAS mutants; CD209 (DC-SIGN) signaling; Signaling by high-kinase activity BRAF mutants; GP1b-IX-V activation signalling; Signaling by moderate kinase activity BRAF mutants; Stimuli-sensing channels; Negative feedback regulation of MAPK pathway; Rap1 signalling; Paradoxical activation of RAF signaling by kinase inactive BRAF; CREB phosphorylation through the activation of Ras; RAF activation; Interleukin-20 family signaling,147,High,1
P63208,S-phase kinase-associated protein 1 OS=Homo sapiens OX=9606 GN=SKP1 PE=1 SV=2,0,62.484,38,6,88,6,163,18.6,4.54,45519,0,6,1,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,"Pf01466, Pf03931",6500,ENSG00000113558.18,SKP1,5,Circadian rhythm; TGF-beta signaling pathway; Cell cycle; Wnt signaling pathway; Ubiquitin mediated proteolysis; Herpes simplex infection; Oocyte meiosis; Protein processing in endoplasmic reticulum,TNF alpha Signaling Pathway; TGF-beta Signaling Pathway; Notch Signaling Pathway,FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; NOTCH1 Intracellular Domain Regulates Transcription; Downstream TCR signaling; Regulation of PLK1 Activity at G2/M Transition; NIK-->noncanonical NF-kB signaling; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; MAP3K8 (TPL2)-dependent MAPK1/3 activation; Antigen processing: Ubiquitination & Proteasome degradation; Iron uptake and transport; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; Activated TLR4 signalling; Interleukin-1 family signaling; Degradation of GLI1 by the proteasome; SCF-beta-TrCP mediated degradation of Emi1; Degradation of GLI2 by the proteasome; Vpu mediated degradation of CD4; Regulation of RUNX2 expression and activity; Cyclin D associated events in G1; Prolactin receptor signaling; FCERI mediated NF-kB activation; Neddylation; Circadian Clock; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling; Dectin-1 mediated noncanonical NF-kB signaling,105,High,1
Q14258,E3 ubiquitin/ISG15 ligase TRIM25 OS=Homo sapiens OX=9606 GN=TRIM25 PE=1 SV=2,0,62.427,20,11,70,11,630,70.9,8.09,27793,0,11,1,defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,catalytic activity;metal ion binding;motor activity;protein binding;RNA binding,"Pf00097, Pf00622, Pf01576, Pf13445, Pf13639, Pf13765, Pf13920, Pf13923, Pf14634, Pf15227",7706,ENSG00000121060.16,TRIM25,17,NF-kappa B signaling pathway; Influenza A; RIG-I-like receptor signaling pathway,RIG-I-like Receptor Signaling,Termination of translesion DNA synthesis; ISG15 antiviral mechanism; Interferon gamma signaling; Negative regulators of DDX58/IFIH1 signaling; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; TRAF6 mediated NF-kB activation; TRAF6 mediated IRF7 activation; Ovarian tumor domain proteases; TRAF3-dependent IRF activation pathway,25,High,1
P52888,Thimet oligopeptidase OS=Homo sapiens OX=9606 GN=THOP1 PE=1 SV=2,0,62.385,17,10,68,9,689,78.8,6.05,28065,,10,,metabolic process,cytoplasm;cytosol,catalytic activity;metal ion binding,Pf01432,7064,ENSG00000172009.14,THOP1,19,African trypanosomiasis; Renin-angiotensin system,,Antigen processing: Ubiquitination & Proteasome degradation,6,High,1
P01111,GTPase NRas OS=Homo sapiens OX=9606 GN=NRAS PE=1 SV=1,0,62.361,44,9,123,1,189,21.2,5.17,58283,,9,,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,Golgi;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00009, Pf00071, Pf02421, Pf08477",4893,ENSG00000213281.4,NRAS,1,Insulin signaling pathway; Rap1 signaling pathway; Long-term potentiation; Proteoglycans in cancer; Ras signaling pathway; T cell receptor signaling pathway; B cell receptor signaling pathway; ErbB signaling pathway; HTLV-I infection; Thyroid cancer; Cholinergic synapse; Viral carcinogenesis; Phospholipase D signaling pathway; Endometrial cancer; Renal cell carcinoma; Sphingolipid signaling pathway; Axon guidance; FoxO signaling pathway; Non-small cell lung cancer; Glioma; mTOR signaling pathway; Endocrine resistance; Hepatitis B; VEGF signaling pathway; Prostate cancer; Melanogenesis; Hepatitis C; PI3K-Akt signaling pathway; Longevity regulating pathway - multiple species; Chronic myeloid leukemia; Natural killer cell mediated cytotoxicity; EGFR tyrosine kinase inhibitor resistance; Bladder cancer; Estrogen signaling pathway; Prolactin signaling pathway; Oxytocin signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Long-term depression; Chemokine signaling pathway; Thyroid hormone signaling pathway; Pathways in cancer; Longevity regulating pathway; Breast cancer; Signaling pathways regulating pluripotency of stem cells; MAPK signaling pathway; GnRH signaling pathway; Acute myeloid leukemia; Alcoholism; Neurotrophin signaling pathway; Fc epsilon RI signaling pathway; MicroRNAs in cancer; Regulation of actin cytoskeleton; Central carbon metabolism in cancer; Choline metabolism in cancer; Tight junction; Apoptosis; Serotonergic synapse; Melanoma; Gap junction,Signaling Pathways in Glioblastoma; RalA downstream regulated genes; TNF alpha Signaling Pathway; Aryl Hydrocarbon Receptor; Extracellular vesicle-mediated signaling in recipient cells; Rac1/Pak1/p38/MMP-2 pathway; G Protein Signaling Pathways; BDNF-TrkB Signaling; MAPK Signaling Pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Chemokine signaling pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; MAPK Cascade; Regulation of Actin Cytoskeleton; DNA Damage Response (only ATM dependent); Serotonin Receptor 2 and ELK-SRF/GATA4 signaling,"Regulation of RAS by GAPs; SHC-mediated cascade:FGFR4; Signaling by FGFR4 in disease; FRS-mediated FGFR4 signaling; SHC1 events in ERBB4 signaling; NCAM signaling for neurite out-growth; DAP12 signaling; Neutrophil degranulation; GRB2 events in EGFR signaling; Signaling by BRAF and RAF fusions; Constitutive Signaling by EGFRvIII; Signaling by RAS mutants; CD209 (DC-SIGN) signaling; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; FRS-mediated FGFR3 signaling; SHC-mediated cascade:FGFR3; FRS-mediated FGFR2 signaling; FRS-mediated FGFR1 signaling; VEGFR2 mediated cell proliferation; SHC-mediated cascade:FGFR1; GRB2 events in ERBB2 signaling; RAF activation; Tie2 Signaling; SHC1 events in ERBB2 signaling; SHC-related events triggered by IGF1R; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by FGFR2 in disease; FCERI mediated MAPK activation; Signaling by FGFR3 fusions in cancer; Downstream signal transduction; Signaling by FGFR3 point mutants in cancer; Signaling by FGFR1 in disease; MET activates RAS signaling; Signaling by GPCR; Paradoxical activation of RAF signaling by kinase inactive BRAF; RAS signaling downstream of NF1 loss-of-function variants; SHC-mediated cascade:FGFR2; EGFR Transactivation by Gastrin; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; SOS-mediated signalling; Interleukin-20 family signaling; SHC1 events in EGFR signaling; p38MAPK events; Activation of RAS in B cells; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Signaling by SCF-KIT",179,High,1
Q9BVV7,Mitochondrial import inner membrane translocase subunit Tim21 OS=Homo sapiens OX=9606 GN=TIMM21 PE=1 SV=1,0,62.273,34,10,183,10,248,28.2,9.7,73993,0,10,1,cell organization and biogenesis;transport,membrane;mitochondrion,protein binding,"Pf08294, Pf08695",29090,ENSG00000075336.11,TIMM21,18,,,Mitochondrial protein import; Metabolism of proteins,2,High,1
Q969M1,Mitochondrial import receptor subunit TOM40B OS=Homo sapiens OX=9606 GN=TOMM40L PE=1 SV=1,0,62.263,31,7,53,7,308,33.9,7.24,25519,,7,,transport,membrane;mitochondrion,transporter activity,Pf01459,84134,ENSG00000158882.14,TOMM40L,1,Amyotrophic lateral sclerosis (ALS),,,1,High,1
Q96B97,SH3 domain-containing kinase-binding protein 1 OS=Homo sapiens OX=9606 GN=SH3KBP1 PE=1 SV=2,0,62.234,22,14,63,14,665,73.1,6.62,25648,,14,,cell communication;cell death;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;membrane,catalytic activity;protein binding,"Pf00018, Pf07653, Pf14604",30011,ENSG00000147010.17,SH3KBP1,X,Endocytosis,EGF/EGFR Signaling Pathway,Cargo recognition for clathrin-mediated endocytosis; Negative regulation of MET activity; Reelin signalling pathway; EGFR downregulation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; InlB-mediated entry of Listeria monocytogenes into host cell,23,High,1
Q9Y315,Deoxyribose-phosphate aldolase OS=Homo sapiens OX=9606 GN=DERA PE=1 SV=2,0,62.217,34,8,41,8,318,35.2,8.94,20607,,8,,metabolic process;transport,cytoplasm;cytosol;extracellular;nucleus;organelle lumen,catalytic activity,Pf01791,51071,ENSG00000023697.12,DERA,12,Pentose phosphate pathway,,Neutrophil degranulation; Pentose phosphate pathway (hexose monophosphate shunt),7,High,1
P15289,Arylsulfatase A OS=Homo sapiens OX=9606 GN=ARSA PE=1 SV=3,0,62.164,23,7,72,7,507,53.6,6.07,27667,,7,,metabolic process;transport,extracellular;organelle lumen;vacuole,catalytic activity;metal ion binding;protein binding,"Pf00884, Pf01663, Pf14707",410,,ARSA,22,Sphingolipid metabolism; Lysosome,,The activation of arylsulfatases; Glycosphingolipid metabolism; Neutrophil degranulation,13,High,1
P30050,60S ribosomal protein L12 OS=Homo sapiens OX=9606 GN=RPL12 PE=1 SV=1,0,62.097,45,5,164,5,165,17.8,9.42,63494,24.3,3,4,cell organization and biogenesis;metabolic process;transport,cytosol;membrane;ribosome,protein binding;RNA binding;structural molecule activity,"Pf00298, Pf03946",6136,ENSG00000197958.12,RPL12,9,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
O14907,Tax1-binding protein 3 OS=Homo sapiens OX=9606 GN=TAX1BP3 PE=1 SV=2,0,62.069,40,4,106,4,124,13.7,8.48,44199,55.12,4,1,regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,protein binding,"Pf00595, Pf13180",30851,ENSG00000213977.7,TAX1BP3,17,,,RHO GTPases Activate Rhotekin and Rhophilins,4,High,1
P14406,"Cytochrome c oxidase subunit 7A2, mitochondrial OS=Homo sapiens OX=9606 GN=COX7A2 PE=1 SV=1",0,62.062,58,7,190,7,83,9.4,9.76,84678,0,7,1,metabolic process;transport,membrane;mitochondrion,catalytic activity;transporter activity,Pf02238,1347,,COX7A2,6,Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Huntington's disease; Cardiac muscle contraction; Parkinson's disease,Electron Transport Chain,,7,High,1
Q14689,Disco-interacting protein 2 homolog A OS=Homo sapiens OX=9606 GN=DIP2A PE=1 SV=2,0,62.042,11,14,121,6,1571,170.3,8.03,49231,,14,,development;metabolic process;regulation of biological process,cell surface;nucleus,catalytic activity;protein binding,"Pf00501, Pf06464",23181,ENSG00000160305.17,DIP2A,21,,Mesodermal Commitment Pathway,,1,High,1
Q68D91,Metallo-beta-lactamase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=MBLAC2 PE=1 SV=3,0,61.986,45,10,61,10,279,31.4,6.92,26239,,10,,,,catalytic activity;metal ion binding,"Pf00753, Pf12706",153364,ENSG00000176055.9,MBLAC2,5,,,,0,High,1
Q8WUP2,Filamin-binding LIM protein 1 OS=Homo sapiens OX=9606 GN=FBLIM1 PE=1 SV=2,0,61.97,19,9,61,9,373,40.6,6.02,26255,5.26,9,1,cell organization and biogenesis;regulation of biological process,cytoplasm;cytoskeleton;cytosol,metal ion binding;protein binding,Pf00412,54751,ENSG00000162458.12,FBLIM1,1,,,Cell-extracellular matrix interactions,3,High,1
Q9UKV3,Apoptotic chromatin condensation inducer in the nucleus OS=Homo sapiens OX=9606 GN=ACIN1 PE=1 SV=2,0,61.956,12,14,59,14,1341,151.8,6.43,24801,,14,,cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process,cytosol;membrane;nucleus,catalytic activity;protein binding;RNA binding,"Pf02037, Pf13893",22985,ENSG00000100813.14,ACIN1,14,Spliceosome; mRNA surveillance pathway; RNA transport,,Apoptotic cleavage of cellular proteins,7,High,1
Q96K17,Transcription factor BTF3 homolog 4 OS=Homo sapiens OX=9606 GN=BTF3L4 PE=1 SV=1,0,61.891,65,7,59,7,158,17.3,6.35,23262,0,7,1,,,protein binding,Pf01849,91408,ENSG00000134717.17,BTF3L4,1,,,,0,High,1
P28072,Proteasome subunit beta type-6 OS=Homo sapiens OX=9606 GN=PSMB6 PE=1 SV=4,0,61.885,54,7,138,7,239,25.3,4.92,67258,0,7,1,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus;proteasome,catalytic activity;protein binding,Pf00227,5694,ENSG00000142507.9,PSMB6,17,Proteasome,Proteasome Degradation,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,150,High,1
P59998,Actin-related protein 2/3 complex subunit 4 OS=Homo sapiens OX=9606 GN=ARPC4 PE=1 SV=3,0,61.873,43,7,150,7,168,19.7,8.43,75264,,7,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol,protein binding;structural molecule activity,Pf05856,10093,ENSG00000241553.12,ARPC4,3,Shigellosis; Pathogenic Escherichia coli infection; Bacterial invasion of epithelial cells; Salmonella infection; Endocytosis; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton,Pathogenic Escherichia coli infection,EPHB-mediated forward signaling; Clathrin-mediated endocytosis; RHO GTPases Activate WASPs and WAVEs; Regulation of actin dynamics for phagocytic cup formation,23,High,1
Q9ULQ1-3,Isoform 3 of Two pore calcium channel protein 1 OS=Homo sapiens OX=9606 GN=TPCN1,0,61.784,14,10,40,10,888,101.7,7.15,18715,3.32,9,2,cellular homeostasis;regulation of biological process;transport,endosome;membrane;vacuole,protein binding;transporter activity,Pf00520,53373,ENSG00000186815.12,TPCN1,12,,,,0,High,1
Q96DP5,"Methionyl-tRNA formyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=MTFMT PE=1 SV=2",0,61.662,35,10,52,10,389,43.8,9.66,21859,9.19,9,3,metabolic process,mitochondrion,catalytic activity,"Pf00551, Pf02911",123263,ENSG00000103707.9,MTFMT,15,Aminoacyl-tRNA biosynthesis; One carbon pool by folate,One Carbon Metabolism,Mitochondrial translation initiation,7,High,1
Q63HQ2-2,Isoform 2 of Pikachurin OS=Homo sapiens OX=9606 GN=EGFLAM,0,61.629,15,13,63,13,1009,110.3,7.5,24547,2.06,12,2,cell organization and biogenesis;metabolic process;regulation of biological process,,metal ion binding;protein binding,"Pf00008, Pf00041, Pf00054, Pf02210, Pf13385",133584,ENSG00000164318.17,EGFLAM,5,,,,0,High,1
Q9Y3E1,Hepatoma-derived growth factor-related protein 3 OS=Homo sapiens OX=9606 GN=HDGFL3 PE=1 SV=1,0,61.525,32,7,83,4,203,22.6,7.99,36229,0,7,1,cell organization and biogenesis;cell proliferation;regulation of biological process,cytoplasm;cytosol;extracellular;nucleus,protein binding,Pf00855,50810,ENSG00000166503.8,HDGFRP3; HDGFL3,15,,,,0,High,1
Q9H2W6,"39S ribosomal protein L46, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL46 PE=1 SV=1",0,61.491,34,8,84,8,279,31.7,7.05,41874,,8,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,catalytic activity;structural molecule activity,Pf11788,26589,ENSG00000259494.1,MRPL46,15,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
P36969,Phospholipid hydroperoxide glutathione peroxidase OS=Homo sapiens OX=9606 GN=GPX4 PE=1 SV=3,0,61.49,31,7,187,7,197,22.2,8.37,83731,2.07,7,1,cell organization and biogenesis;development;metabolic process;response to stimulus,cytoplasm;cytosol;mitochondrion;nucleus,antioxidant activity;catalytic activity;protein binding,Pf00255,2879,ENSG00000167468.16,GPX4,19,Glutathione metabolism,Glutathione metabolism; Selenium Micronutrient Network; Folate Metabolism; Selenium Metabolism and Selenoproteins; One carbon metabolism and related pathways; Metapathway biotransformation,Synthesis of 12-eicosatetraenoic acid derivatives; Synthesis of 15-eicosatetraenoic acid derivatives; Synthesis of 5-eicosatetraenoic acids,14,High,1
Q96RU2,Ubiquitin carboxyl-terminal hydrolase 28 OS=Homo sapiens OX=9606 GN=USP28 PE=1 SV=1,0,61.415,13,12,61,11,1077,122.4,5.2,24762,,12,,cell proliferation;metabolic process;regulation of biological process;response to stimulus,nucleus,catalytic activity;protein binding,"Pf00443, Pf13423",57646,ENSG00000048028.11,USP28,11,,,Ub-specific processing proteases,4,High,1
O95571,"Persulfide dioxygenase ETHE1, mitochondrial OS=Homo sapiens OX=9606 GN=ETHE1 PE=1 SV=2",0,61.393,25,6,104,6,254,27.9,6.83,46782,,6,,metabolic process,cytoplasm;mitochondrion;nucleus;organelle lumen,catalytic activity;metal ion binding,"Pf00753, Pf12706",23474,ENSG00000105755.7,ETHE1,19,Sulfur metabolism,,Sulfide oxidation to sulfate,6,High,1
Q15369,Elongin-C OS=Homo sapiens OX=9606 GN=ELOC PE=1 SV=1,0,61.346,49,5,136,5,112,12.5,4.78,60157,13.64,4,2,metabolic process;regulation of biological process;response to stimulus,cytosol;nucleus,catalytic activity;protein binding;RNA binding,Pf03931,6921,ENSG00000154582.16,TCEB1; ELOC,8,Ubiquitin mediated proteolysis; Pathways in cancer; Renal cell carcinoma; HIF-1 signaling pathway,Dual hijack model of Vif in HIV infection,Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Tat-mediated HIV elongation arrest and recovery; Vif-mediated degradation of APOBEC3G; Pausing and recovery of HIV elongation; Antigen processing: Ubiquitination & Proteasome degradation; Interleukin-7 signaling; Neddylation; Formation of HIV-1 elongation complex containing HIV-1 Tat; HIV elongation arrest and recovery; TP53 Regulates Transcription of DNA Repair Genes; Regulation of expression of SLITs and ROBOs; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase II Pre-transcription Events; Pausing and recovery of Tat-mediated HIV elongation,48,High,1
Q8N3E9,"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 OS=Homo sapiens OX=9606 GN=PLCD3 PE=1 SV=3",0,61.285,17,11,47,11,789,89.2,6.98,17960,,11,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;metal ion binding;protein binding;signal transducer activity,"Pf00168, Pf00169, Pf00387, Pf00388, Pf09279, Pf14788",113026,ENSG00000161714.11,PLCD3,17,AGE-RAGE signaling pathway in diabetic complications; Metabolic pathways; Thyroid hormone signaling pathway; Calcium signaling pathway; Inositol phosphate metabolism; Phosphatidylinositol signaling system,GPR40 PATHWAY,Synthesis of IP3 and IP4 in the cytosol,10,High,1
O95302,Peptidyl-prolyl cis-trans isomerase FKBP9 OS=Homo sapiens OX=9606 GN=FKBP9 PE=1 SV=2,0,61.279,24,12,60,12,570,63,5.08,23459,,12,,metabolic process,cytoplasm;endoplasmic reticulum,catalytic activity;metal ion binding,"Pf00254, Pf13499",11328,ENSG00000122642.10,FKBP9,7,,,Association of TriC/CCT with target proteins during biosynthesis,4,High,1
Q07955,Serine/arginine-rich splicing factor 1 OS=Homo sapiens OX=9606 GN=SRSF1 PE=1 SV=2,0,61.278,38,11,170,10,248,27.7,10.36,73527,0,11,1,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;nucleus;spliceosomal complex,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",6426,ENSG00000136450.12,SRSF1,17,Spliceosome; Herpes simplex infection,mRNA Processing,Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway,15,High,1
Q12988,Heat shock protein beta-3 OS=Homo sapiens OX=9606 GN=HSPB3 PE=1 SV=2,0,61.236,41,8,136,7,150,17,6.02,61301,22.18,8,2,response to stimulus,cytoplasm;nucleus,,Pf00011,8988,ENSG00000169271.2,HSPB3,5,,,,0,High,1
A1A4S6,Rho GTPase-activating protein 10 OS=Homo sapiens OX=9606 GN=ARHGAP10 PE=1 SV=1,0,61.21,20,12,54,11,786,89.3,7.18,22448,,12,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,enzyme regulator activity;protein binding,"Pf00018, Pf00169, Pf00620, Pf07653, Pf14604",79658,ENSG00000071205.11,ARHGAP10,4,Bacterial invasion of epithelial cells,Ectoderm Differentiation,Regulation of PAK-2p34 activity by PS-GAP/RHG10; Rho GTPase cycle,9,High,1
Q99598,Translin-associated protein X OS=Homo sapiens OX=9606 GN=TSNAX PE=1 SV=1,0,61.184,55,12,70,12,290,33.1,6.55,25068,0,12,1,cell differentiation;development;metabolic process;response to stimulus;transport,cytoplasm;cytosol;Golgi;nucleus,DNA binding;metal ion binding;protein binding;RNA binding;transporter activity,Pf01997,7257,ENSG00000116918.13,TSNAX,1,,,Small interfering RNA (siRNA) biogenesis,3,High,1
Q5VW36,Focadhesin OS=Homo sapiens OX=9606 GN=FOCAD PE=1 SV=1,0,61.158,9,13,60,13,1801,199.9,6.62,23177,,13,,,membrane,protein binding,"Pf11229, Pf12530",54914,,FOCAD,9,,,,0,High,1
Q15165-1,Isoform 1 of Serum paraoxonase/arylesterase 2 OS=Homo sapiens OX=9606 GN=PON2,0,61.097,36,7,41,7,354,39.4,5.5,17492,,7,,,,,,,,,,,,,0,High,1
P51178,"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 OS=Homo sapiens OX=9606 GN=PLCD1 PE=1 SV=2",0,61.064,24,12,55,12,756,85.6,6.7,21201,,12,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;metal ion binding;protein binding;signal transducer activity,"Pf00168, Pf00169, Pf00387, Pf00388, Pf09279, Pf14788",5333,ENSG00000187091.13,PLCD1,3,Metabolic pathways; AGE-RAGE signaling pathway in diabetic complications; Thyroid hormone signaling pathway; Calcium signaling pathway; Inositol phosphate metabolism; Phosphatidylinositol signaling system,Myometrial Relaxation and Contraction Pathways; GPR40 PATHWAY,Synthesis of IP3 and IP4 in the cytosol,11,High,1
Q9H8Y8,Golgi reassembly-stacking protein 2 OS=Homo sapiens OX=9606 GN=GORASP2 PE=1 SV=3,0,61.018,23,9,79,9,452,47.1,4.82,35974,0,9,1,cell organization and biogenesis,Golgi;membrane,protein binding,Pf04495,26003,ENSG00000115806.12,GORASP2,2,,,Golgi Cisternae Pericentriolar Stack Reorganization,5,High,1
Q9GZT6,"Coiled-coil domain-containing protein 90B, mitochondrial OS=Homo sapiens OX=9606 GN=CCDC90B PE=1 SV=2",0,60.984,33,8,60,8,254,29.5,7.55,28594,,8,,,membrane;mitochondrion,protein binding,Pf07798,60492,ENSG00000137500.9,CCDC90B,11,,,,0,High,1
P14324,Farnesyl pyrophosphate synthase OS=Homo sapiens OX=9606 GN=FDPS PE=1 SV=4,0,60.904,23,8,66,8,419,48.2,6.15,32490,,8,,metabolic process;regulation of biological process,cytoplasm;cytosol;mitochondrion,catalytic activity;metal ion binding;RNA binding,Pf00348,2224,ENSG00000160752.14,FDPS,1,Metabolic pathways; HTLV-I infection; Influenza A; Terpenoid backbone biosynthesis,Cholesterol Biosynthesis; Sterol Regulatory Element-Binding Proteins (SREBP) signalling,Cholesterol biosynthesis; Activation of gene expression by SREBF (SREBP),12,High,1
P20340,Ras-related protein Rab-6A OS=Homo sapiens OX=9606 GN=RAB6A PE=1 SV=3,0,60.898,59,12,217,1,208,23.6,5.54,105719,1.93,12,2,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;Golgi;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf02421, Pf04670, Pf08477, Pf09439",5870,ENSG00000175582.19,RAB6A,11,,,COPI-independent Golgi-to-ER retrograde traffic; TBC/RABGAPs; Neutrophil degranulation; Pre-NOTCH Processing in Golgi; Retrograde transport at the Trans-Golgi-Network; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation,19,High,1
O15247,Chloride intracellular channel protein 2 OS=Homo sapiens OX=9606 GN=CLIC2 PE=1 SV=3,0,60.876,47,9,94,8,247,28.3,5.59,40438,,9,,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;membrane;nucleus,antioxidant activity;catalytic activity;protein binding;transporter activity,"Pf13409, Pf13410, Pf13417",1193,ENSG00000155962.12,CLIC2,X,,,Ion homeostasis; Stimuli-sensing channels,6,High,1
Q9Y4X5,E3 ubiquitin-protein ligase ARIH1 OS=Homo sapiens OX=9606 GN=ARIH1 PE=1 SV=2,0,60.808,17,7,88,7,557,64.1,5.08,40228,,7,,metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;protein binding,Pf01485,25820,ENSG00000166233.14,ARIH1,15,,,ISG15 antiviral mechanism,5,High,1
Q92621,Nuclear pore complex protein Nup205 OS=Homo sapiens OX=9606 GN=NUP205 PE=1 SV=3,0,60.776,10,16,64,16,2012,227.8,6.19,21510,0,16,1,cell organization and biogenesis;metabolic process;regulation of biological process;transport,membrane;nucleus,protein binding;structural molecule activity,Pf11894,23165,ENSG00000155561.14,NUP205,7,RNA transport,,Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins,64,High,1
P63000,Ras-related C3 botulinum toxin substrate 1 OS=Homo sapiens OX=9606 GN=RAC1 PE=1 SV=1,0,60.714,28,6,138,4,192,21.4,8.5,61684,34.26,5,1,cell organization and biogenesis;cell proliferation;cellular component movement;coagulation;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf08477",5879,ENSG00000136238.17,RAC1,7,B cell receptor signaling pathway; Pancreatic secretion; Bacterial invasion of epithelial cells; PI3K-Akt signaling pathway; Osteoclast differentiation; AGE-RAGE signaling pathway in diabetic complications; Leukocyte transendothelial migration; Chemokine signaling pathway; Colorectal cancer; Salmonella infection; Ras signaling pathway; VEGF signaling pathway; Focal adhesion; Fc epsilon RI signaling pathway; Shigellosis; Pancreatic cancer; Phagosome; Sphingolipid signaling pathway; Axon guidance; Pathways in cancer; Regulation of actin cytoskeleton; Fc gamma R-mediated phagocytosis; MAPK signaling pathway; Choline metabolism in cancer; Amyotrophic lateral sclerosis (ALS); Wnt signaling pathway; Renal cell carcinoma; Natural killer cell mediated cytotoxicity; Rap1 signaling pathway; Neurotrophin signaling pathway; cAMP signaling pathway; Viral carcinogenesis; Epithelial cell signaling in Helicobacter pylori infection; Viral myocarditis; Toll-like receptor signaling pathway; Non-alcoholic fatty liver disease (NAFLD); Adherens junction; Proteoglycans in cancer,Androgen receptor signaling pathway; Nucleotide-binding Oligomerization Domain (NOD) pathway; Regulation of toll-like receptor signaling pathway; Target Of Rapamycin (TOR) Signaling; Physiological and Pathological Hypertrophy  of the Heart; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated Cell Adhesion; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; Leptin signaling pathway; TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway; Prolactin Signaling Pathway; Regulation of Microtubule Cytoskeleton; RalA downstream regulated genes; B Cell Receptor Signaling Pathway; TNF alpha Signaling Pathway; AGE/RAGE pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Spinal Cord Injury; Alpha 6 Beta 4 signaling pathway; Amyotrophic lateral sclerosis (ALS); Cardiac Hypertrophic Response; Focal Adhesion; Rac1/Pak1/p38/MMP-2 pathway; Wnt Signaling Pathway Netpath; IL-6 signaling pathway; Hepatitis C and Hepatocellular Carcinoma; TGF-beta Signaling Pathway; MAPK Signaling Pathway; VEGFA-VEGFR2 Signaling Pathway; Chemokine signaling pathway; Microglia Pathogen Phagocytosis Pathway; Robo4 and VEGF Signaling Pathways Crosstalk; p38 MAPK Signaling Pathway; Wnt Signaling Pathway; EGF/EGFR Signaling Pathway; Insulin Signaling; Regulation of Actin Cytoskeleton; G13 Signaling Pathway; Interferon type I signaling pathways; DNA Damage Response (only ATM dependent); Toll-like receptor signaling pathway,"SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Sema3A PAK dependent Axon repulsion; Rho GTPase cycle; FCERI mediated MAPK activation; MET activates RAP1 and RAC1; RHO GTPases activate CIT; Factors involved in megakaryocyte development and platelet production; PCP/CE pathway; Nef and signal transduction; RHO GTPases Activate NADPH Oxidases; Translocation of GLUT4 to the plasma membrane; EPH-ephrin mediated repulsion of cells; Ephrin signaling; DAP12 signaling; EPHB-mediated forward signaling; NRAGE signals death through JNK; Neutrophil degranulation; Sema4D induced cell migration and growth-cone collapse; Regulation of actin dynamics for phagocytic cup formation; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; RHO GTPases activate PAKs; G alpha (12/13) signalling events; DCC mediated attractive signaling; Signal transduction by L1; RHO GTPases activate KTN1; RHO GTPases activate IQGAPs; Activation of RAC1; Inactivation of CDC42 and RAC1; CD28 dependent Vav1 pathway; GPVI-mediated activation cascade; DSCAM interactions; RHO GTPases Activate WASPs and WAVEs; VEGFR2 mediated vascular permeability; Sema4D mediated inhibition of cell attachment and migration; RHO GTPases Activate Formins; Signaling by SCF-KIT; MAPK6/MAPK4 signaling; Signalling by NGF; RHO GTPases activate PKNs",160,High,1
P61457,Pterin-4-alpha-carbinolamine dehydratase OS=Homo sapiens OX=9606 GN=PCBD1 PE=1 SV=2,0,60.581,42,5,225,5,104,12,6.8,100344,0,5,1,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,Pf01329,5092,ENSG00000166228.8,PCBD1,10,,,Phenylalanine and tyrosine catabolism,4,High,1
P63027,Vesicle-associated membrane protein 2 OS=Homo sapiens OX=9606 GN=VAMP2 PE=1 SV=3,0,60.554,59,4,46,2,116,12.7,8.13,23378,,4,,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytosol;membrane,protein binding,Pf00957,6844,ENSG00000220205.8,VAMP2,17,Insulin secretion; SNARE interactions in vesicular transport; Vasopressin-regulated water reabsorption; Synaptic vesicle cycle; Salivary secretion,Synaptic Vesicle Pathway; Insulin Signaling; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,"Cargo recognition for clathrin-mediated endocytosis; Glutamate Neurotransmitter Release Cycle; Toxicity of botulinum toxin type D (BoNT/D); Insulin processing; Toxicity of botulinum toxin type B (BoNT/B); Acetylcholine Neurotransmitter Release Cycle; Golgi Associated Vesicle Biogenesis; GABA synthesis, release, reuptake and degradation; Other interleukin signaling; Lysosome Vesicle Biogenesis; Translocation of GLUT4 to the plasma membrane; Serotonin Neurotransmitter Release Cycle; Regulation of insulin secretion; Toxicity of tetanus toxin (TeNT); Norepinephrine Neurotransmitter Release Cycle; Toxicity of botulinum toxin type G (BoNT/G); Dopamine Neurotransmitter Release Cycle; Toxicity of botulinum toxin type F (BoNT/F)",45,High,1
Q9Y2Q9,"28S ribosomal protein S28, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS28 PE=1 SV=1",0,60.516,43,6,195,6,187,20.8,9.1,75797,2.29,6,1,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,RNA binding,"Pf00575, Pf10246",28957,ENSG00000147586.9,MRPS28,8,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
Q9NZ01,Very-long-chain enoyl-CoA reductase OS=Homo sapiens OX=9606 GN=TECR PE=1 SV=1,0,60.516,26,9,81,9,308,36,9.45,35304,,9,,metabolic process,cytoplasm;endoplasmic reticulum;membrane;nucleus,catalytic activity;protein binding,Pf02544,9524,ENSG00000099797.13,TECR,19,Biosynthesis of unsaturated fatty acids; Fatty acid metabolism; Fatty acid elongation,,Synthesis of very long-chain fatty acyl-CoAs,8,High,1
Q9Y4P1,Cysteine protease ATG4B OS=Homo sapiens OX=9606 GN=ATG4B PE=1 SV=2,0,60.333,31,10,50,10,393,44.3,5.07,24404,,10,,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol,catalytic activity;protein binding,Pf03416,23192,ENSG00000168397.16,ATG4B,2,Autophagy,,Macroautophagy,3,High,1
Q9P1Z2,Calcium-binding and coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CALCOCO1 PE=1 SV=2,0,60.301,21,11,39,11,691,77.3,4.82,18343,,11,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;nucleus,catalytic activity;DNA binding;motor activity;protein binding,"Pf01576, Pf03961, Pf04111, Pf05557, Pf05622, Pf05667, Pf06160, Pf06785, Pf07888, Pf08317, Pf09789, Pf10186, Pf12128, Pf13166, Pf13514, Pf13851",57658,ENSG00000012822.15,CALCOCO1,12,,,,0,High,1
Q53R41,"FAST kinase domain-containing protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=FASTKD1 PE=1 SV=1",0,60.301,17,12,49,12,847,97.3,7.74,19611,,12,,metabolic process,mitochondrion,catalytic activity;RNA binding,"Pf06743, Pf08368, Pf08373",79675,ENSG00000138399.17,FASTKD1,2,,,,0,High,1
Q9H553,"Alpha-1,3/1,6-mannosyltransferase ALG2 OS=Homo sapiens OX=9606 GN=ALG2 PE=1 SV=1",0,60.284,27,9,44,9,416,47.1,7.05,20115,,9,,metabolic process;response to stimulus,cytoplasm;membrane;nucleus,catalytic activity;protein binding,"Pf00534, Pf13439, Pf13524, Pf13579, Pf13692",85365,ENSG00000119523.9,ALG2,9,N-Glycan biosynthesis; Metabolic pathways,,"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG2 causes ALG2-CDG (CDG-1i)",10,High,1
P49756,RNA-binding protein 25 OS=Homo sapiens OX=9606 GN=RBM25 PE=1 SV=3,0,60.229,19,13,55,13,843,100.1,6.32,25962,,13,,metabolic process;regulation of biological process,cytoplasm;nucleus;spliceosomal complex,protein binding;RNA binding,"Pf00076, Pf01480, Pf14259",58517,ENSG00000119707.13,RBM25,14,Spliceosome,,,1,High,1
P78406,mRNA export factor OS=Homo sapiens OX=9606 GN=RAE1 PE=1 SV=1,0,60.217,41,9,50,9,368,40.9,7.83,19432,,9,,cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;nucleus,protein binding;RNA binding,Pf00400,8480,ENSG00000101146.12,RAE1,20,RNA transport; Influenza A,,Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins,65,High,1
Q9Y399,"28S ribosomal protein S2, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS2 PE=1 SV=1",0,60.177,30,10,140,10,296,33.2,9.26,62559,0,10,1,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,structural molecule activity,Pf00318,51116,ENSG00000122140.10,MRPS2,9,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
Q15043,Zinc transporter ZIP14 OS=Homo sapiens OX=9606 GN=SLC39A14 PE=1 SV=3,0,60.148,13,8,50,8,492,54.2,5.33,20632,,8,,cellular homeostasis;transport,cytoplasm;membrane,transporter activity,Pf02535,23516,ENSG00000104635.13,SLC39A14,8,,NRF2 pathway; Zinc homeostasis,Zinc influx into cells by the SLC39 gene family,8,High,1
Q5VZE5,"N-alpha-acetyltransferase 35, NatC auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA35 PE=1 SV=1",0,60.098,19,11,57,11,725,83.6,7.05,24440,,11,,cell proliferation;metabolic process;regulation of biological process,cytoplasm,catalytic activity;protein binding,Pf04112,60560,ENSG00000135040.15,NAA35,9,,,Retrograde transport at the Trans-Golgi-Network,4,High,1
P16402,Histone H1.3 OS=Homo sapiens OX=9606 GN=H1-3 PE=1 SV=2,0,60.083,22,10,488,1,221,22.3,11.02,266627,3.01,10,3,cell organization and biogenesis;metabolic process;regulation of biological process,chromosome;nucleus,DNA binding;RNA binding,Pf00538,3007,ENSG00000124575.6,HIST1H1D,6,,,Formation of Senescence-Associated Heterochromatin Foci (SAHF); Activation of DNA fragmentation factor,10,High,1
Q9H903,Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 OS=Homo sapiens OX=9606 GN=MTHFD2L PE=2 SV=3,0,60.071,50,11,42,11,347,37.3,9.33,16458,17.73,7,4,metabolic process,cytosol;membrane;mitochondrion;organelle lumen,catalytic activity,"Pf00763, Pf02882",441024,ENSG00000163738.18,MTHFD2L,4,,Trans-sulfuration and one carbon metabolism,Metabolism of folate and pterines,5,High,1
Q00765,Receptor expression-enhancing protein 5 OS=Homo sapiens OX=9606 GN=REEP5 PE=1 SV=3,0,60.023,24,7,168,7,189,21.5,8.1,90608,4.27,7,1,,endoplasmic reticulum;membrane,protein binding,Pf03134,7905,ENSG00000129625.12,REEP5,5,,,Olfactory Signaling Pathway; GPCR downstream signalling,4,High,1
Q16740,"ATP-dependent Clp protease proteolytic subunit, mitochondrial OS=Homo sapiens OX=9606 GN=CLPP PE=1 SV=1",0,60.021,39,9,192,9,277,30.2,8.09,80024,,9,,cell organization and biogenesis;metabolic process,mitochondrion;organelle lumen,catalytic activity;protein binding,Pf00574,8192,ENSG00000125656.8,CLPP,19,,,,0,High,1
A6NDG6,Glycerol-3-phosphate phosphatase OS=Homo sapiens OX=9606 GN=PGP PE=1 SV=1,0,60.001,25,8,150,8,321,34,6.14,78570,0,8,1,metabolic process;regulation of biological process,cytosol,catalytic activity;metal ion binding,"Pf00702, Pf13242, Pf13344, Pf13419",283871,ENSG00000184207.8,PGP,16,Metabolic pathways; Glyoxylate and dicarboxylate metabolism; Carbon metabolism,,Glycolysis,7,High,1
Q6QEF8-5,Isoform 5 of Coronin-6 OS=Homo sapiens OX=9606 GN=CORO6,0,59.97,17,7,106,5,472,53,6.15,37932,25.72,6,2,cell organization and biogenesis,cytoskeleton,protein binding,"Pf00400, Pf08953, Pf08954",84940,ENSG00000167549.18,CORO6,17,,,,0,High,1
P62873,Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 OS=Homo sapiens OX=9606 GN=GNB1 PE=1 SV=3,0,59.944,29,7,238,5,340,37.4,6,108843,2.05,5,2,cell death;cell organization and biogenesis;cell proliferation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cytosol;membrane,catalytic activity;protein binding;signal transducer activity,Pf00400,2782,ENSG00000078369.17,GNB1,1,Glutamatergic synapse; PI3K-Akt signaling pathway; Dopaminergic synapse; Ras signaling pathway; Retrograde endocannabinoid signaling; Circadian entrainment; Phototransduction; Chemokine signaling pathway; GABAergic synapse; Morphine addiction; Cholinergic synapse; Alcoholism; Pathways in cancer; Olfactory transduction; Serotonergic synapse,Nicotine Activity on Dopaminergic Neurons; Human Thyroid Stimulating Hormone (TSH) signaling pathway; Corticotropin-releasing hormone signaling pathway; Myometrial Relaxation and Contraction Pathways; G Protein Signaling Pathways; Chemokine signaling pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Calcium Regulation in the Cardiac Cell; Estrogen signaling pathway,"G alpha (z) signalling events; Activation of G protein gated Potassium channels; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; ADP signalling through P2Y purinoceptor 1; Olfactory Signaling Pathway; G beta:gamma signalling through PI3Kgamma; Vasopressin regulates renal water homeostasis via Aquaporins; G-protein activation; Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits; G alpha (12/13) signalling events; Ca2+ pathway; ADP signalling through P2Y purinoceptor 12; Adrenaline,noradrenaline inhibits insulin secretion; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Presynaptic function of Kainate receptors; G beta:gamma signalling through PLC beta; Glucagon signaling in metabolic regulation; Thrombin signalling through proteinase activated receptors (PARs); Prostacyclin signalling through prostacyclin receptor; Gastrin-CREB signalling pathway via PKC and MAPK; Activation of the phototransduction cascade; Inactivation, recovery and regulation of the phototransduction cascade",84,High,1
Q9BU61,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 OS=Homo sapiens OX=9606 GN=NDUFAF3 PE=1 SV=1,0,59.928,42,7,134,7,184,20.3,8.22,64898,0,7,1,cell organization and biogenesis,membrane;mitochondrion;nucleus,protein binding,Pf04430,25915,ENSG00000178057.14,NDUFAF3,3,,,Complex I biogenesis,5,High,1
Q9UHY1,Nuclear receptor-binding protein OS=Homo sapiens OX=9606 GN=NRBP1 PE=1 SV=1,0,59.912,24,9,48,9,535,59.8,5.08,20158,0,9,1,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf07714",29959,ENSG00000115216.13,NRBP1,2,,,Nuclear Receptor transcription pathway,4,High,1
Q92542,Nicastrin OS=Homo sapiens OX=9606 GN=NCSTN PE=1 SV=2,0,59.862,18,10,73,10,709,78.4,5.99,36184,1.76,10,1,cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;Golgi;membrane,catalytic activity;protein binding,Pf05450,23385,ENSG00000162736.15,NCSTN,1,Alzheimer's disease; Notch signaling pathway,Alzheimers Disease; Notch Signaling Pathway; Notch Signaling Pathway,Activated NOTCH1 Transmits Signal to the Nucleus; Signaling by NOTCH4; Regulated proteolysis of p75NTR; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NRIF signals cell death from the nucleus; Signaling by NOTCH3; EPH-ephrin mediated repulsion of cells; NOTCH2 Activation and Transmission of Signal to the Nucleus; Degradation of the extracellular matrix; Neutrophil degranulation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Nuclear signaling by ERBB4; Signalling by NGF,37,High,1
Q13867,Bleomycin hydrolase OS=Homo sapiens OX=9606 GN=BLMH PE=1 SV=1,0,59.862,24,7,103,7,455,52.5,6.27,45799,,7,,metabolic process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,Pf03051,642,ENSG00000108578.14,BLMH,17,,,Antigen processing: Ubiquitination & Proteasome degradation,4,High,1
O15273,Telethonin OS=Homo sapiens OX=9606 GN=TCAP PE=1 SV=1,0,59.853,54,7,412,7,167,19,5.25,190565,41.89,4,6,cell organization and biogenesis;cellular component movement;response to stimulus,cytoplasm;cytosol,protein binding;structural molecule activity,Pf09470,8557,ENSG00000173991.5,TCAP,17,,Striated Muscle Contraction,Striated Muscle Contraction,3,High,1
Q96S19,Methyltransferase-like 26 OS=Homo sapiens OX=9606 GN=METTL26 PE=1 SV=2,0,59.844,51,9,87,9,204,22.6,7.83,40818,0,9,2,,,catalytic activity,"Pf05175, Pf06080, Pf13649, Pf13659",84326,ENSG00000130731.15,C16orf13; METTL26,16,,,,0,High,1
Q15154-5,Isoform 5 of Pericentriolar material 1 protein OS=Homo sapiens OX=9606 GN=PCM1,0,59.83,8,13,56,12,2016,227.6,5.03,22005,3.7,12,1,,,,,,,,,,,,0,High,1
O95260-2,Isoform ATE1-2 of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1,0,59.813,21,8,46,8,518,59,7.02,17578,10.62,7,1,metabolic process,cytoplasm;nucleus,catalytic activity;protein binding,"Pf04376, Pf04377",11101,ENSG00000107669.17,ATE1,10,,,,0,High,1
Q9H3U1,Protein unc-45 homolog A OS=Homo sapiens OX=9606 GN=UNC45A PE=1 SV=1,0,59.804,17,13,38,13,944,103,6.07,15353,,13,,cell differentiation;development;metabolic process,cytoplasm;cytosol;Golgi;nucleus,protein binding,"Pf00515, Pf07719, Pf11701, Pf12895, Pf13181, Pf13414, Pf13424, Pf13432, Pf14559",55898,ENSG00000140553.17,UNC45A,15,,,,0,High,1
A0A0B4J1V0,Immunoglobulin heavy variable 3-15 OS=Homo sapiens OX=9606 GN=IGHV3-15 PE=3 SV=1,0,59.792,53,9,107,8,119,12.9,8.62,52800,,9,,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,protein binding,,28448,ENSG00000211943.2; ENSG00000282290.1,IGHV3-15,14; CHR_HSCHR14_3_CTG1,,,,0,High,1
Q14642,Inositol polyphosphate-5-phosphatase A OS=Homo sapiens OX=9606 GN=INPP5A PE=1 SV=1,0,59.766,23,9,47,9,412,47.8,7.03,21384,,9,,metabolic process;regulation of biological process;response to stimulus,membrane,catalytic activity;protein binding,,3632,ENSG00000068383.18,INPP5A,10,Metabolic pathways; Phosphatidylinositol signaling system; Inositol phosphate metabolism,,"Synthesis of IP2, IP, and Ins in the cytosol",6,High,1
Q5RI15,"Cytochrome c oxidase assembly protein COX20, mitochondrial OS=Homo sapiens OX=9606 GN=COX20 PE=1 SV=2",0,59.733,42,6,64,6,118,13.3,8.76,29346,3.1,6,1,cell organization and biogenesis;metabolic process,membrane;mitochondrion,,Pf12597,116228,ENSG00000203667.9,COX20,1,,,TP53 Regulates Metabolic Genes; Respiratory electron transport,9,High,1
O43676,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 OS=Homo sapiens OX=9606 GN=NDUFB3 PE=1 SV=3,0,59.682,47,7,815,7,98,11.4,9.2,390673,15.17,6,4,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion,catalytic activity;transporter activity,Pf08122,4709,ENSG00000119013.8,NDUFB3,2,Metabolic pathways; Alzheimer's disease; Non-alcoholic fatty liver disease (NAFLD); Parkinson's disease; Oxidative phosphorylation; Huntington's disease,Electron Transport Chain,Complex I biogenesis,12,High,1
Q9BWD1,"Acetyl-CoA acetyltransferase, cytosolic OS=Homo sapiens OX=9606 GN=ACAT2 PE=1 SV=2",0,59.619,29,7,46,7,397,41.3,6.92,24177,,7,,metabolic process,cytoplasm;cytosol;mitochondrion;nucleus,catalytic activity;protein binding,"Pf00108, Pf00109, Pf02803",39,ENSG00000120437.8,ACAT2,6,"Terpenoid backbone biosynthesis; Propanoate metabolism; Glyoxylate and dicarboxylate metabolism; Pyruvate metabolism; Fat digestion and absorption; Fatty acid metabolism; Carbon metabolism; Tryptophan metabolism; Fatty acid degradation; Metabolic pathways; Butanoate metabolism; Synthesis and degradation of ketone bodies; Lysine degradation; Valine, leucine and isoleucine degradation",,Cholesterol biosynthesis,18,High,1
Q9NZN5,Rho guanine nucleotide exchange factor 12 OS=Homo sapiens OX=9606 GN=ARHGEF12 PE=1 SV=1,0,59.523,11,15,43,15,1544,173.1,5.74,17928,,15,,regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,enzyme regulator activity;protein binding,"Pf00595, Pf00621, Pf09128, Pf13180",23365,ENSG00000196914.8,ARHGEF12,11,Pathways in cancer; Proteoglycans in cancer; Platelet activation; Regulation of actin cytoskeleton; Tuberculosis; Vascular smooth muscle contraction; Axon guidance,,G alpha (12/13) signalling events; NRAGE signals death through JNK; Sema4D induced cell migration and growth-cone collapse; Rho GTPase cycle; Signalling by NGF,23,High,1
Q9BRJ2,"39S ribosomal protein L45, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL45 PE=1 SV=2",0,59.512,33,12,102,12,306,35.3,9.03,47556,,12,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,protein binding;RNA binding,Pf04280,84311,ENSG00000277936.4,MRPL45,17; CHR_HSCHR17_7_CTG4,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
Q6P1Q0,LETM1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=LETMD1 PE=1 SV=1,0,59.511,30,10,95,10,360,41.8,10.32,42476,0,10,2,cellular homeostasis,membrane;mitochondrion,protein binding,Pf07766,25875,ENSG00000050426.15,LETMD1,12,,,,0,High,1
P53367,Arfaptin-1 OS=Homo sapiens OX=9606 GN=ARFIP1 PE=1 SV=2,0,59.51,37,9,29,9,373,41.7,6.7,13369,,9,,regulation of biological process;transport,cytoplasm;cytosol;membrane,protein binding,"Pf03114, Pf06456",27236,ENSG00000164144.15,ARFIP1,4,,,,0,High,1
P01116-2,Isoform 2B of GTPase KRas OS=Homo sapiens OX=9606 GN=KRAS,0,59.481,44,9,120,3,188,21.4,8.12,54634,2.69,8,1,cell communication;cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding,"Pf00009, Pf00071, Pf02421, Pf08477",3845,ENSG00000133703.11,KRAS,12,,IL-5 Signaling Pathway; Integrated Breast Cancer Pathway; Signaling Pathways in Glioblastoma; RalA downstream regulated genes; TNF alpha Signaling Pathway; Oncostatin M Signaling Pathway; Aryl Hydrocarbon Receptor; Extracellular vesicle-mediated signaling in recipient cells; Rac1/Pak1/p38/MMP-2 pathway; G Protein Signaling Pathways; BDNF-TrkB Signaling; MAPK Signaling Pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Chemokine signaling pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; MAPK Cascade; EGF/EGFR Signaling Pathway; Regulation of Actin Cytoskeleton; ErbB Signaling Pathway; DNA Damage Response (only ATM dependent); Serotonin Receptor 2 and ELK-SRF/GATA4 signaling,,21,High,1
Q9UHV9,Prefoldin subunit 2 OS=Homo sapiens OX=9606 GN=PFDN2 PE=1 SV=1,0,59.448,40,6,122,6,154,16.6,6.58,63241,,6,,metabolic process;regulation of biological process,cytoplasm;cytosol;mitochondrion;nucleus,protein binding,Pf01920,5202,ENSG00000143256.4,PFDN2,1,,,Prefoldin mediated transfer of substrate  to CCT/TriC,5,High,1
O14618,Copper chaperone for superoxide dismutase OS=Homo sapiens OX=9606 GN=CCS PE=1 SV=1,0,59.405,38,6,81,6,274,29,5.58,37700,9.37,6,1,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus,antioxidant activity;catalytic activity;enzyme regulator activity;metal ion binding;protein binding,"Pf00080, Pf00403",9973,ENSG00000173992.8,CCS,11,Amyotrophic lateral sclerosis (ALS),Amyotrophic lateral sclerosis (ALS); Copper homeostasis,Detoxification of Reactive Oxygen Species,6,High,1
Q6ZSR9,Uncharacterized protein FLJ45252 OS=Homo sapiens OX=9606 PE=2 SV=2,0,59.392,41,9,44,9,355,38,5.26,19118,,9,,,,,Pf15282,,,,,,,,0,High,1
Q96E39,"RNA binding motif protein, X-linked-like-1 OS=Homo sapiens OX=9606 GN=RBMXL1 PE=1 SV=1",0,59.358,18,6,98,2,390,42.1,9.89,51253,,6,,metabolic process;regulation of biological process,nucleus,DNA binding;RNA binding,"Pf00076, Pf08081, Pf13893, Pf14259",494115,ENSG00000213516.9,RBMXL1,1,Spliceosome,,,1,High,1
P62753,40S ribosomal protein S6 OS=Homo sapiens OX=9606 GN=RPS6 PE=1 SV=1,0,59.308,19,7,106,7,249,28.7,10.84,52520,2.26,6,2,cell death;cell differentiation;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus;ribosome,protein binding;RNA binding;structural molecule activity,Pf01092,6194,ENSG00000137154.12,RPS6,9,Insulin signaling pathway; PI3K-Akt signaling pathway; EGFR tyrosine kinase inhibitor resistance; Ribosome; mTOR signaling pathway; HIF-1 signaling pathway; Proteoglycans in cancer,IL-5 Signaling Pathway; Human Thyroid Stimulating Hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle Stimulating Hormone (FSH) signaling pathway; Prolactin Signaling Pathway; Interleukin-11 Signaling Pathway; Oncostatin M Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Kit receptor signaling pathway; Mecp2 and Associated Rett Syndrome; VEGFA-VEGFR2 Signaling Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Cytoplasmic Ribosomal Proteins; IL-2 Signaling Pathway; Interferon type I signaling pathways,"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; mTORC1-mediated signalling; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane",62,High,1
P08123,Collagen alpha-2(I) chain OS=Homo sapiens OX=9606 GN=COL1A2 PE=1 SV=7,0,59.298,6,6,80,6,1366,129.2,8.95,38526,,6,,cell organization and biogenesis;cellular component movement;coagulation;metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;extracellular;organelle lumen,metal ion binding;protein binding;structural molecule activity,"Pf01391, Pf01410",1278,ENSG00000164692.17,COL1A2,7,ECM-receptor interaction; Protein digestion and absorption; Platelet activation; Focal adhesion; Amoebiasis; PI3K-Akt signaling pathway; AGE-RAGE signaling pathway in diabetic complications,miRNA targets in ECM and membrane receptors; Focal Adhesion; TGF-beta Signaling Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Inflammatory Response Pathway,Collagen degradation; Integrin cell surface interactions; MET activates PTK2 signaling; Crosslinking of collagen fibrils; Anchoring fibril formation; Platelet Adhesion to exposed collagen; Scavenging by Class A Receptors; Syndecan interactions; GP1b-IX-V activation signalling; ECM proteoglycans; Platelet Aggregation (Plug Formation); Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Collagen chain trimerization; GPVI-mediated activation cascade; Cell surface interactions at the vascular wall; Interleukin-4 and 13 signaling,46,High,1
Q99614,Tetratricopeptide repeat protein 1 OS=Homo sapiens OX=9606 GN=TTC1 PE=1 SV=1,0,59.212,31,9,73,9,292,33.5,4.84,33610,,9,,metabolic process,cytosol;membrane,protein binding,"Pf00515, Pf13371, Pf13414, Pf13432, Pf13525",7265,ENSG00000113312.10,TTC1,5,,,,0,High,1
Q9UKU9,Angiopoietin-related protein 2 OS=Homo sapiens OX=9606 GN=ANGPTL2 PE=1 SV=1,0,59.212,25,12,51,11,493,57.1,7.53,19258,0,11,2,development,extracellular,protein binding,Pf00147,23452,ENSG00000136859.9,ANGPTL2,9,,,,0,High,1
Q96QG7,Myotubularin-related protein 9 OS=Homo sapiens OX=9606 GN=MTMR9 PE=1 SV=1,0,59.197,20,10,55,10,549,63.4,6.39,25602,,10,,metabolic process;regulation of biological process,cytoplasm;cytosol,catalytic activity;enzyme regulator activity;protein binding,Pf06602,66036,ENSG00000104643.9,MTMR9,8,,,"Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the late endosome membrane; Synthesis of IP2, IP, and Ins in the cytosol",8,High,1
P01112,GTPase HRas OS=Homo sapiens OX=9606 GN=HRAS PE=1 SV=1,0,59.189,38,8,119,1,189,21.3,5.31,54779,,8,,cell communication;cell death;cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;Golgi;membrane;mitochondrion;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00009, Pf00071, Pf02421, Pf03599, Pf08477",3265,ENSG00000276536.4; ENSG00000174775.16,HRAS,11; CHR_HSCHR11_1_CTG8,Serotonergic synapse; MicroRNAs in cancer; Endometrial cancer; Renal cell carcinoma; mTOR signaling pathway; GnRH signaling pathway; Central carbon metabolism in cancer; Non-small cell lung cancer; Glioma; Jak-STAT signaling pathway; Alcoholism; Tight junction; VEGF signaling pathway; Prostate cancer; Apoptosis; Fc epsilon RI signaling pathway; Cholinergic synapse; Endocytosis; Chronic myeloid leukemia; Natural killer cell mediated cytotoxicity; Melanoma; Regulation of actin cytoskeleton; Axon guidance; Prolactin signaling pathway; Oxytocin signaling pathway; Gap junction; Choline metabolism in cancer; Endocrine resistance; Insulin signaling pathway; Rap1 signaling pathway; Long-term potentiation; Focal adhesion; Hepatitis C; Longevity regulating pathway; T cell receptor signaling pathway; B cell receptor signaling pathway; ErbB signaling pathway; HTLV-I infection; Bladder cancer; Signaling pathways regulating pluripotency of stem cells; Phospholipase D signaling pathway; Long-term depression; FoxO signaling pathway; Proteoglycans in cancer; Hepatitis B; Melanogenesis; Longevity regulating pathway - multiple species; EGFR tyrosine kinase inhibitor resistance; Viral carcinogenesis; AGE-RAGE signaling pathway in diabetic complications; Thyroid hormone signaling pathway; PI3K-Akt signaling pathway; Pathways in cancer; Estrogen signaling pathway; Breast cancer; Chemokine signaling pathway; MAPK signaling pathway; Ras signaling pathway; Acute myeloid leukemia; Thyroid cancer; Neurotrophin signaling pathway; Sphingolipid signaling pathway,Integrin-mediated Cell Adhesion; Human Thyroid Stimulating Hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin Signaling Pathway; Signaling Pathways in Glioblastoma; RalA downstream regulated genes; B Cell Receptor Signaling Pathway; TNF alpha Signaling Pathway; Interleukin-11 Signaling Pathway; Oncostatin M Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Alpha 6 Beta 4 signaling pathway; PDGF Pathway; Aryl Hydrocarbon Receptor; Bladder Cancer; IL-3 Signaling Pathway; Extracellular vesicle-mediated signaling in recipient cells; Kit receptor signaling pathway; Focal Adhesion; Signaling of Hepatocyte Growth Factor Receptor; Rac1/Pak1/p38/MMP-2 pathway; G Protein Signaling Pathways; Pathways Affected in Adenoid Cystic Carcinoma; BDNF-TrkB Signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; ERK Pathway in Huntington's Disease; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; Chemokine signaling pathway; ESC Pluripotency Pathways; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; p38 MAPK Signaling Pathway; MAPK Cascade; EGF/EGFR Signaling Pathway; Insulin Signaling; IL-2 Signaling Pathway; TGF-beta Receptor Signaling; Senescence and Autophagy in Cancer; ErbB Signaling Pathway; T-Cell antigen Receptor (TCR)  Signaling Pathway; DNA Damage Response (only ATM dependent); Serotonin Receptor 2 and ELK-SRF/GATA4 signaling,"Regulation of RAS by GAPs; SHC-mediated cascade:FGFR4; Signaling by FGFR4 in disease; FRS-mediated FGFR4 signaling; SHC1 events in ERBB4 signaling; NCAM signaling for neurite out-growth; DAP12 signaling; GRB2 events in EGFR signaling; Signaling by BRAF and RAF fusions; Constitutive Signaling by EGFRvIII; Signaling by RAS mutants; CD209 (DC-SIGN) signaling; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; FRS-mediated FGFR3 signaling; SHC-mediated cascade:FGFR3; FRS-mediated FGFR2 signaling; FRS-mediated FGFR1 signaling; VEGFR2 mediated cell proliferation; SHC-mediated cascade:FGFR1; GRB2 events in ERBB2 signaling; RAF activation; Tie2 Signaling; SHC1 events in ERBB2 signaling; SHC-related events triggered by IGF1R; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by FGFR2 in disease; FCERI mediated MAPK activation; Signaling by FGFR3 fusions in cancer; Downstream signal transduction; Signaling by FGFR3 point mutants in cancer; Signaling by FGFR1 in disease; MET activates RAS signaling; Signaling by GPCR; Paradoxical activation of RAF signaling by kinase inactive BRAF; EPHB-mediated forward signaling; RAS signaling downstream of NF1 loss-of-function variants; SHC-mediated cascade:FGFR2; EGFR Transactivation by Gastrin; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; SOS-mediated signalling; Interleukin-20 family signaling; SHC1 events in EGFR signaling; p38MAPK events; Ras activation uopn Ca2+ infux through NMDA receptor; Activation of RAS in B cells; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Signaling by SCF-KIT",216,High,1
Q2UY09,Collagen alpha-1(XXVIII) chain OS=Homo sapiens OX=9606 GN=COL28A1 PE=2 SV=2,0,59.167,13,9,27,9,1125,116.6,6.4,12801,0,9,2,regulation of biological process,extracellular;organelle lumen,enzyme regulator activity,"Pf00014, Pf00092, Pf01391, Pf13519",340267,ENSG00000215018.9,COL28A1,7,,,Collagen chain trimerization,4,High,1
Q9Y2L5,Trafficking protein particle complex subunit 8 OS=Homo sapiens OX=9606 GN=TRAPPC8 PE=1 SV=2,0,59.138,13,15,59,15,1435,160.9,6.87,23537,,15,,cell organization and biogenesis;metabolic process;transport,cytosol;Golgi,protein binding,Pf12739,22878,ENSG00000153339.13,TRAPPC8,18,,,RAB GEFs exchange GTP for GDP on RABs,4,High,1
P05204,Non-histone chromosomal protein HMG-17 OS=Homo sapiens OX=9606 GN=HMGN2 PE=1 SV=3,0,59.125,17,6,631,5,90,9.4,9.99,305872,,6,,,chromosome;cytoplasm;nucleus,DNA binding;protein binding;RNA binding,,3151,ENSG00000198830.10,HMGN2,1,,,,0,High,1
Q16513,Serine/threonine-protein kinase N2 OS=Homo sapiens OX=9606 GN=PKN2 PE=1 SV=1,0,59.019,19,14,53,14,984,112,6.3,21269,,14,,cell death;cell division;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00069, Pf00433, Pf02185, Pf07714, Pf14531",5586,ENSG00000065243.19,PKN2,1,Salmonella infection; PI3K-Akt signaling pathway,,RHO GTPases activate PKNs,6,High,1
Q9H5Q4,"Dimethyladenosine transferase 2, mitochondrial OS=Homo sapiens OX=9606 GN=TFB2M PE=1 SV=1",0,58.954,28,10,57,10,396,45.3,9.19,25820,,10,,cell organization and biogenesis;metabolic process;regulation of biological process,mitochondrion;organelle lumen,catalytic activity;RNA binding,Pf00398,64216,ENSG00000162851.7,TFB2M,1,,Energy Metabolism; Mitochondrial Gene Expression,Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis,8,High,1
Q9NRX2,"39S ribosomal protein L17, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL17 PE=1 SV=1",0,58.821,36,8,112,8,175,20,10.11,52577,,8,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,protein binding;structural molecule activity,Pf01196,63875,ENSG00000158042.8,MRPL17,11,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
Q8NFW8,N-acylneuraminate cytidylyltransferase OS=Homo sapiens OX=9606 GN=CMAS PE=1 SV=2,0,58.81,23,8,94,8,434,48.3,7.93,38106,8.46,8,1,metabolic process,membrane;nucleus,catalytic activity,"Pf02348, Pf12804",55907,ENSG00000111726.12,CMAS,12,Metabolic pathways; Amino sugar and nucleotide sugar metabolism,,Sialic acid metabolism,8,High,1
Q14353,Guanidinoacetate N-methyltransferase OS=Homo sapiens OX=9606 GN=GAMT PE=1 SV=1,0,58.79,39,6,96,6,236,26.3,6.14,44054,,6,,metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity,Pf13659,2593,ENSG00000130005.12,GAMT,19,"Glycine, serine and threonine metabolism; Metabolic pathways; Arginine and proline metabolism",Mecp2 and Associated Rett Syndrome; Urea cycle and metabolism of amino groups,Creatine metabolism,9,High,1
Q92769,Histone deacetylase 2 OS=Homo sapiens OX=9606 GN=HDAC2 PE=1 SV=2,0,58.777,26,9,62,5,488,55.3,5.91,24683,0,9,1,cell differentiation;cell organization and biogenesis;coagulation;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;nucleus,catalytic activity;DNA binding;protein binding;RNA binding,Pf00850,3066,ENSG00000196591.11,HDAC2,6,Chronic myeloid leukemia; Alcoholism; Huntington's disease; Viral carcinogenesis; Transcriptional misregulation in cancer; Pathways in cancer; Epstein-Barr virus infection; Cell cycle; Longevity regulating pathway - multiple species; Notch signaling pathway; Thyroid hormone signaling pathway,Cell Cycle; Neural Crest Differentiation; Notch Signaling Pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Notch Signaling Pathway,NOTCH1 Intracellular Domain Regulates Transcription; Regulation of TP53 Activity through Acetylation; NoRC negatively regulates rRNA expression; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Factors involved in megakaryocyte development and platelet production; SUMOylation of chromatin organization proteins; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of PTEN gene transcription; Constitutive Signaling by NOTCH1 PEST Domain Mutants; HDACs deacetylate histones; p75NTR negatively regulates cell cycle via SC1; Signalling by NGF; RNA Polymerase I Transcription Initiation,59,High,1
Q9NP80,Calcium-independent phospholipase A2-gamma OS=Homo sapiens OX=9606 GN=PNPLA8 PE=1 SV=1,0,58.709,19,13,90,12,782,88.4,9.23,38880,,13,,cell death;metabolic process;transport,cytoplasm;endoplasmic reticulum;Golgi;membrane,catalytic activity;nucleotide binding,Pf01734,50640,ENSG00000135241.16,PNPLA8,7,,Eicosanoid Synthesis,Acyl chain remodelling of PE; Acyl chain remodelling of PC,7,High,1
Q6P1M0,Long-chain fatty acid transport protein 4 OS=Homo sapiens OX=9606 GN=SLC27A4 PE=1 SV=1,0,58.623,19,10,74,9,643,72,8.47,38193,,10,,metabolic process;response to stimulus;transport,endoplasmic reticulum;membrane,catalytic activity;nucleotide binding;transporter activity,"Pf00501, Pf13193",10999,ENSG00000167114.12,SLC27A4,9,PPAR signaling pathway; Fat digestion and absorption; Insulin resistance,PPAR signaling pathway,Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS); Transport of fatty acids,12,High,1
Q9Y3B8-3,"Isoform 3 of Oligoribonuclease, mitochondrial OS=Homo sapiens OX=9606 GN=REXO2",0,58.623,41,8,116,1,205,23.7,5.87,52263,5.65,6,3,metabolic process,mitochondrion;nucleus;organelle lumen,catalytic activity,Pf00929,25996,,REXO2,11,,,,0,High,1
Q63HN8,E3 ubiquitin-protein ligase RNF213 OS=Homo sapiens OX=9606 GN=RNF213 PE=1 SV=3,0,58.622,4,16,74,16,5207,591,6.48,29172,,16,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;membrane,catalytic activity;metal ion binding;protein binding,"Pf00097, Pf13639, Pf13920, Pf13923, Pf15227",57674,,RNF213,17,,,Antigen processing: Ubiquitination & Proteasome degradation,4,High,1
P32455,Guanylate-binding protein 1 OS=Homo sapiens OX=9606 GN=GBP1 PE=1 SV=2,0,58.603,21,11,86,10,592,67.9,6.32,37010,,11,,cell organization and biogenesis;defense response;regulation of biological process;response to stimulus,cytoplasm;cytosol;extracellular;Golgi;membrane,catalytic activity;nucleotide binding;protein binding,"Pf02263, Pf02841, Pf05879",2633,ENSG00000117228.9,GBP1,1,NOD-like receptor signaling pathway,Type II interferon signaling (IFNG),Interferon gamma signaling,6,High,1
P52815,"39S ribosomal protein L12, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL12 PE=1 SV=2",0,58.596,35,4,71,4,198,21.3,8.87,34722,7.58,3,1,cell organization and biogenesis;metabolic process;regulation of biological process,membrane;mitochondrion;ribosome,protein binding;RNA binding;structural molecule activity,Pf00542,6182,ENSG00000262814.7,MRPL12,17,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
Q9BSL1,Ubiquitin-associated domain-containing protein 1 OS=Homo sapiens OX=9606 GN=UBAC1 PE=1 SV=1,0,58.59,30,10,74,10,405,45.3,4.92,32584,,10,,metabolic process,cytoplasm;cytosol;Golgi;membrane,protein binding,Pf00627,10422,ENSG00000130560.8,UBAC1,9,,,Antigen processing: Ubiquitination & Proteasome degradation,4,High,1
P0C870,Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7 OS=Homo sapiens OX=9606 GN=JMJD7 PE=1 SV=1,0,58.578,35,9,60,9,316,35.9,5.38,29659,0,9,1,,,protein binding,Pf13621,100137047,ENSG00000243789.10,JMJD7,15,,,,0,High,1
Q8IXJ6,NAD-dependent protein deacetylase sirtuin-2 OS=Homo sapiens OX=9606 GN=SIRT2 PE=1 SV=2,0,58.538,29,9,70,9,389,43.2,5.36,29825,,9,,cell communication;cell differentiation;cell division;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,Pf02146,22933,ENSG00000283100.1; ENSG00000068903.19,SIRT2,19; CHR_HG26_PATCH,,NAD+ metabolism; NAD+ biosynthetic pathways,,2,High,1
Q9BU02,Thiamine-triphosphatase OS=Homo sapiens OX=9606 GN=THTPA PE=1 SV=3,0,58.532,41,8,63,8,230,25.6,4.82,28850,,8,,metabolic process,cytoplasm;cytosol,catalytic activity;metal ion binding,Pf01928,79178,ENSG00000259431.5,THTPA,14,Thiamine metabolism; Metabolic pathways,,Vitamin B1 (thiamin) metabolism,6,High,1
Q96CS3,FAS-associated factor 2 OS=Homo sapiens OX=9606 GN=FAF2 PE=1 SV=2,0,58.503,25,8,85,8,445,52.6,5.62,33149,,8,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;extracellular;organelle lumen,enzyme regulator activity;protein binding,"Pf00789, Pf14555",23197,ENSG00000113194.12,FAF2,5,,,Neutrophil degranulation,3,High,1
P17812,CTP synthase 1 OS=Homo sapiens OX=9606 GN=CTPS1 PE=1 SV=2,0,58.477,19,10,52,10,591,66.6,6.46,22360,,10,,cell proliferation;metabolic process;response to stimulus,cytosol;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00117, Pf06418, Pf07722",1503,ENSG00000171793.13,CTPS1,1,Pyrimidine metabolism; Metabolic pathways,,Interconversion of nucleotide di- and triphosphates,5,High,1
P15104,Glutamine synthetase OS=Homo sapiens OX=9606 GN=GLUL PE=1 SV=4,0,58.472,17,6,38,6,373,42,6.89,17713,,6,,cell communication;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;mitochondrion;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00120, Pf03951",2752,ENSG00000135821.17,GLUL,1,"Nitrogen metabolism; Alanine, aspartate and glutamate metabolism; Glyoxylate and dicarboxylate metabolism; GABAergic synapse; Glutamatergic synapse; Metabolic pathways; Biosynthesis of amino acids; Arginine biosynthesis",TNF alpha Signaling Pathway; Amino Acid metabolism,Amino acid synthesis and interconversion (transamination); Astrocytic Glutamate-Glutamine Uptake And Metabolism,17,High,1
Q15020,Squamous cell carcinoma antigen recognized by T-cells 3 OS=Homo sapiens OX=9606 GN=SART3 PE=1 SV=1,0,58.431,15,14,55,14,963,109.9,5.57,23309,,14,,cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process,cytoplasm;nucleus,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",9733,ENSG00000075856.11,SART3,12,,,,0,High,1
Q9P0M9,"39S ribosomal protein L27, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL27 PE=1 SV=1",0,58.425,41,5,95,5,148,16.1,10.42,38356,,5,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,protein binding;RNA binding;structural molecule activity,Pf01016,51264,ENSG00000108826.15,MRPL27,17,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
P35659,Protein DEK OS=Homo sapiens OX=9606 GN=DEK PE=1 SV=1,0,58.386,25,9,107,9,375,42.6,8.56,47284,0,9,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,nucleus,DNA binding;protein binding;RNA binding,"Pf02037, Pf08766",7913,ENSG00000124795.14,DEK,6,,,Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors; B-WICH complex positively regulates rRNA expression,7,High,1
Q9H0V9,VIP36-like protein OS=Homo sapiens OX=9606 GN=LMAN2L PE=1 SV=1,0,58.363,34,10,57,10,348,39.7,8.38,22478,,10,,metabolic process;transport,endoplasmic reticulum;Golgi;membrane,metal ion binding,Pf03388,81562,ENSG00000114988.11,LMAN2L,2,,,Cargo concentration in the ER; COPII (Coat Protein 2) Mediated Vesicle Transport,9,High,1
Q6PHR2,Serine/threonine-protein kinase ULK3 OS=Homo sapiens OX=9606 GN=ULK3 PE=1 SV=2,0,58.354,37,12,61,12,472,53.4,7.36,20883,,12,,metabolic process;regulation of biological process;response to stimulus,cytoplasm,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf04212, Pf07714",25989,ENSG00000140474.12,ULK3,15,Autophagy; Longevity regulating pathway; mTOR signaling pathway,Target Of Rapamycin (TOR) Signaling,Hedgehog 'on' state,7,High,1
O60216,Double-strand-break repair protein rad21 homolog OS=Homo sapiens OX=9606 GN=RAD21 PE=1 SV=2,0,58.339,20,11,59,11,631,71.6,4.65,26454,2.05,11,1,cell death;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;cytosol;membrane;nucleus,protein binding,"Pf04824, Pf04825",5885,ENSG00000164754.14,RAD21,8,Cell cycle,,Meiotic synapsis; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin; Establishment of Sister Chromatid Cohesion; SUMOylation of DNA damage response and repair proteins,21,High,1
P20336,Ras-related protein Rab-3A OS=Homo sapiens OX=9606 GN=RAB3A PE=1 SV=1,0,58.33,44,7,86,5,220,25,5.03,35452,,7,,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;endosome;membrane,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf08477, Pf09439",5864,ENSG00000105649.9,RAB3A,19,Synaptic vesicle cycle; Insulin secretion,Synaptic Vesicle Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway,"Glutamate Neurotransmitter Release Cycle; Neutrophil degranulation; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; RAB GEFs exchange GTP for GDP on RABs; GABA synthesis, release, reuptake and degradation; RAB geranylgeranylation",23,High,1
P36222,Chitinase-3-like protein 1 OS=Homo sapiens OX=9606 GN=CHI3L1 PE=1 SV=2,0,58.265,32,9,45,9,383,42.6,8.46,20701,0,9,1,cell death;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;extracellular;organelle lumen,catalytic activity;structural molecule activity,Pf00704,1116,ENSG00000133048.12,CHI3L1,1,,,Neutrophil degranulation,3,High,1
P52758,2-iminobutanoate/2-iminopropanoate deaminase OS=Homo sapiens OX=9606 GN=RIDA PE=1 SV=1,0,58.23,50,6,166,6,137,14.5,8.68,76076,0,6,1,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;mitochondrion;nucleus;organelle lumen,catalytic activity;metal ion binding;protein binding;RNA binding,Pf01042,10247,ENSG00000132541.10,HRSP12; RIDA,8,,,,0,High,1
Q9P000,COMM domain-containing protein 9 OS=Homo sapiens OX=9606 GN=COMMD9 PE=1 SV=2,0,58.18,39,6,94,6,198,21.8,5.88,45892,,6,,metabolic process;regulation of biological process;transport,cytosol;extracellular;Golgi;nucleus;organelle lumen,protein binding,Pf07258,29099,ENSG00000110442.11,COMMD9,11,,,Neutrophil degranulation; Neddylation,6,High,1
Q5T160,"Probable arginine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=RARS2 PE=1 SV=1",0,58.147,29,13,62,13,578,65.5,8.21,25861,,13,,cell organization and biogenesis;metabolic process,cytoplasm;mitochondrion;organelle lumen,catalytic activity;nucleotide binding;RNA binding,"Pf00750, Pf05746",57038,ENSG00000146282.17,RARS2,6,Aminoacyl-tRNA biosynthesis,,Mitochondrial tRNA aminoacylation,5,High,1
Q9H8H3,Methyltransferase-like protein 7A OS=Homo sapiens OX=9606 GN=METTL7A PE=1 SV=1,0,58.12,19,6,55,6,244,28.3,8.38,22339,2.62,6,1,metabolic process;transport,endoplasmic reticulum;extracellular;membrane,catalytic activity,"Pf01209, Pf01739, Pf05148, Pf05175, Pf08241, Pf08242, Pf12847, Pf13489, Pf13649, Pf13659, Pf13847",25840,ENSG00000185432.11,METTL7A,12,,,Neutrophil degranulation,3,High,1
Q9H9S4,Calcium-binding protein 39-like OS=Homo sapiens OX=9606 GN=CAB39L PE=1 SV=3,0,57.988,29,10,122,7,337,39.1,8.4,55168,0,10,1,regulation of biological process,cytosol,protein binding,Pf08569,81617,ENSG00000102547.18,CAB39L,13,AMPK signaling pathway; mTOR signaling pathway,Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,Energy dependent regulation of mTOR by LKB1-AMPK,6,High,1
P15502-1,Isoform 1 of Elastin OS=Homo sapiens OX=9606 GN=ELN,0,57.948,28,8,54,8,730,63.2,10.45,24658,2.66,7,2,cell organization and biogenesis;cell proliferation,extracellular,protein binding;structural molecule activity,,2006,ENSG00000049540.16,ELN,7,Protein digestion and absorption,Lung fibrosis,,2,High,1
Q8NFQ8,Torsin-1A-interacting protein 2 OS=Homo sapiens OX=9606 GN=TOR1AIP2 PE=1 SV=1,0,57.939,21,8,62,7,470,51.2,4.96,27104,0,8,1,cell organization and biogenesis;regulation of biological process,endoplasmic reticulum;membrane;nucleus,enzyme regulator activity;protein binding,Pf05609,163590,ENSG00000169905.12,TOR1AIP2,1,,,,0,High,1
P46783,40S ribosomal protein S10 OS=Homo sapiens OX=9606 GN=RPS10 PE=1 SV=1,0,57.925,48,10,189,10,165,18.9,10.15,97982,0,10,1,cell organization and biogenesis;metabolic process;transport,cytoplasm;cytosol;membrane;nucleus;ribosome,protein binding;RNA binding;structural molecule activity,Pf03501,6204,ENSG00000124614.13,RPS10,6,Ribosome,Cytoplasmic Ribosomal Proteins,"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane",38,High,1
Q9GZY4,Cytochrome c oxidase assembly factor 1 homolog OS=Homo sapiens OX=9606 GN=COA1 PE=1 SV=1,0,57.914,55,7,86,7,146,16.7,8.81,35166,8.46,7,1,cell organization and biogenesis;metabolic process,cytosol;membrane;mitochondrion,RNA binding;structural molecule activity,Pf08695,55744,ENSG00000106603.18,COA1,7,,,,0,High,1
P07305,Histone H1.0 OS=Homo sapiens OX=9606 GN=H1-0 PE=1 SV=3,0,57.891,28,7,291,7,194,20.9,10.84,160482,,7,,cell organization and biogenesis;metabolic process,chromosome;cytoskeleton;Golgi;nucleus,DNA binding;protein binding;RNA binding,Pf00538,3005,ENSG00000189060.5,H1F0,22,,,Formation of Senescence-Associated Heterochromatin Foci (SAHF); Activation of DNA fragmentation factor,10,High,1
Q92974,Rho guanine nucleotide exchange factor 2 OS=Homo sapiens OX=9606 GN=ARHGEF2 PE=1 SV=4,0,57.867,16,11,36,11,986,111.5,7.27,14303,0,11,1,cell division;cell organization and biogenesis;defense response;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;Golgi;membrane,metal ion binding;protein binding,"Pf00130, Pf00169, Pf00621, Pf07649",9181,ENSG00000116584.17,ARHGEF2,1,Pathogenic Escherichia coli infection,Pathogenic Escherichia coli infection,G alpha (12/13) signalling events; NRAGE signals death through JNK; Signalling by NGF; Rho GTPase cycle,13,High,1
Q00013,55 kDa erythrocyte membrane protein OS=Homo sapiens OX=9606 GN=MPP1 PE=1 SV=2,0,57.859,37,11,60,11,466,52.3,7.37,24599,0,11,1,metabolic process;regulation of biological process;response to stimulus,cytoskeleton;membrane,catalytic activity;protein binding,"Pf00018, Pf00595, Pf00625, Pf07653, Pf13180, Pf14604",4354,ENSG00000130830.14,MPP1,X,,Mecp2 and Associated Rett Syndrome,,1,High,1
O00461,Golgi integral membrane protein 4 OS=Homo sapiens OX=9606 GN=GOLIM4 PE=1 SV=1,0,57.846,13,8,52,8,696,81.8,4.77,25201,5.56,7,1,transport,endosome;Golgi;membrane;organelle lumen,,,27333,ENSG00000173905.8,GOLIM4,3,,,Intra-Golgi traffic,4,High,1
A6NHZ5,Leucine-rich repeat-containing protein 14B OS=Homo sapiens OX=9606 GN=LRRC14B PE=3 SV=3,0,57.813,28,10,41,10,514,56.7,7.17,3103,86.26,1,9,,,protein binding,Pf13855,389257,ENSG00000185028.3,LRRC14B,5,,,,0,High,1
O60264,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 OS=Homo sapiens OX=9606 GN=SMARCA5 PE=1 SV=1,0,57.775,13,13,46,10,1052,121.8,8.09,21444,,13,,cell organization and biogenesis;metabolic process;regulation of biological process,chromosome;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding,"Pf00176, Pf00270, Pf00271, Pf04851, Pf09110, Pf09111, Pf11496",8467,ENSG00000153147.5,SMARCA5,4,,,Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; NoRC negatively regulates rRNA expression; B-WICH complex positively regulates rRNA expression; Deposition of new CENPA-containing nucleosomes at the centromere,14,High,1
Q9UPT6,C-Jun-amino-terminal kinase-interacting protein 3 OS=Homo sapiens OX=9606 GN=MAPK8IP3 PE=1 SV=3,0,57.756,11,13,42,8,1336,147.4,5.4,15844,,13,,cellular component movement;metabolic process;regulation of biological process;transport,cytoplasm;extracellular;membrane,catalytic activity;motor activity;protein binding;structural molecule activity,"Pf00038, Pf01576, Pf02463, Pf03938, Pf04111, Pf04156, Pf05701, Pf05769, Pf05887, Pf07174, Pf07926, Pf09728, Pf09731, Pf09744, Pf09756, Pf10037, Pf12037, Pf13851, Pf13863, Pf13868, Pf15035",23162,ENSG00000138834.12,MAPK8IP3,16,MAPK signaling pathway,MAPK Signaling Pathway,,2,High,1
O96007,Molybdopterin synthase catalytic subunit OS=Homo sapiens OX=9606 GN=MOCS2 PE=1 SV=1,0,57.696,49,8,57,8,188,20.9,5.44,24145,0,8,1,metabolic process,cytoplasm;cytosol;nucleus,catalytic activity,Pf02391,4338,ENSG00000164172.18,MOCS2,5,Folate biosynthesis; Sulfur relay system; Metabolic pathways,,Molybdenum cofactor biosynthesis,7,High,1
Q9Y2X3,Nucleolar protein 58 OS=Homo sapiens OX=9606 GN=NOP58 PE=1 SV=1,0,57.687,22,9,53,9,529,59.5,8.92,18769,,9,,cell growth;metabolic process,cytosol;membrane;nucleus,protein binding;RNA binding,"Pf01798, Pf08060, Pf08156",51602,ENSG00000055044.10,NOP58,2,Ribosome biogenesis in eukaryotes,,Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; SUMOylation of RNA binding proteins,11,High,1
O60762,Dolichol-phosphate mannosyltransferase subunit 1 OS=Homo sapiens OX=9606 GN=DPM1 PE=1 SV=1,0,57.676,41,9,87,9,260,29.6,9.57,37284,1.66,9,1,metabolic process,endoplasmic reticulum;membrane;nucleus,catalytic activity;protein binding,"Pf00535, Pf10111, Pf13641, Pf13704, Pf13712",8813,ENSG00000000419.12,DPM1,20,Metabolic pathways; N-Glycan biosynthesis,,Defective DPM1 causes DPM1-CDG (CDG-1e); Synthesis of dolichyl-phosphate mannose,13,High,1
Q15005,Signal peptidase complex subunit 2 OS=Homo sapiens OX=9606 GN=SPCS2 PE=1 SV=3,0,57.658,32,7,69,7,226,25,8.47,30880,,7,,metabolic process;transport,endoplasmic reticulum;membrane,catalytic activity,Pf06703,9789,ENSG00000118363.11,SPCS2,11,Protein export,,"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Synthesis, secretion, and deacylation of Ghrelin; SRP-dependent cotranslational protein targeting to membrane; Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)",9,High,1
Q5SW79,Centrosomal protein of 170 kDa OS=Homo sapiens OX=9606 GN=CEP170 PE=1 SV=1,0,57.625,12,13,100,13,1584,175.2,7.11,36003,,13,,,cytoplasm;cytoskeleton;cytosol;membrane,protein binding,"Pf00498, Pf15308",9859,ENSG00000276725.4; ENSG00000143702.15,CEP170,1; CHR_HSCHR1_3_CTG32_1,,,,0,High,1
P08651-2,Isoform 1 of Nuclear factor 1 C-type OS=Homo sapiens OX=9606 GN=NFIC,0,57.603,34,10,40,7,499,54.6,8.46,15409,22.82,9,2,metabolic process;regulation of biological process,nucleus,DNA binding,"Pf00859, Pf03165, Pf10524",4782,ENSG00000141905.17,NFIC,19,,,,0,High,1
Q01085,Nucleolysin TIAR OS=Homo sapiens OX=9606 GN=TIAL1 PE=1 SV=1,0,57.553,29,7,62,5,375,41.6,7.74,29288,,7,,cell death;cell division;defense response;regulation of biological process;response to stimulus,cytoplasm;nucleus;vacuole,DNA binding;RNA binding,"Pf00076, Pf13893, Pf14259",7073,ENSG00000151923.17,TIAL1,10,,,FGFR2 alternative splicing,5,High,1
Q7Z4S6,Kinesin-like protein KIF21A OS=Homo sapiens OX=9606 GN=KIF21A PE=1 SV=2,0,57.551,11,10,40,9,1674,187.1,6.42,15589,,10,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton,catalytic activity;motor activity;nucleotide binding;protein binding;structural molecule activity,"Pf00038, Pf00225, Pf00400, Pf00769, Pf01576, Pf02050, Pf02463, Pf02841, Pf02996, Pf03938, Pf03962, Pf04111, Pf05010, Pf05483, Pf05557, Pf05622, Pf07926, Pf09731, Pf10174, Pf10211, Pf11600, Pf12037, Pf12128, Pf12718, Pf13166, Pf13514, Pf13863, Pf13868, Pf14943, Pf14988, Pf15558, Pf15619",55605,ENSG00000139116.18,KIF21A,12,,,COPI-dependent Golgi-to-ER retrograde traffic; Kinesins,8,High,1
Q86U28,"Iron-sulfur cluster assembly 2 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=ISCA2 PE=1 SV=2",0,57.36,53,8,64,8,154,16.5,5.25,34492,,8,,cell organization and biogenesis;metabolic process,mitochondrion;organelle lumen,metal ion binding;protein binding;structural molecule activity,Pf01521,122961,ENSG00000165898.13,ISCA2,14,,,Mitochondrial iron-sulfur cluster biogenesis,2,High,1
P41227,N-alpha-acetyltransferase 10 OS=Homo sapiens OX=9606 GN=NAA10 PE=1 SV=1,0,57.339,54,11,89,11,235,26.4,5.64,36201,,11,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;nucleus;ribosome,catalytic activity;protein binding,"Pf00583, Pf08445, Pf13508, Pf13527, Pf13673",8260,ENSG00000102030.15,NAA10,X,,,,0,High,1
Q9UKM9,RNA-binding protein Raly OS=Homo sapiens OX=9606 GN=RALY PE=1 SV=1,0,57.328,46,10,91,10,306,32.4,9.17,44303,,10,,metabolic process;regulation of biological process,nucleus;spliceosomal complex,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",22913,ENSG00000125970.11,RALY,20,,,,0,High,1
Q9NR09,Baculoviral IAP repeat-containing protein 6 OS=Homo sapiens OX=9606 GN=BIRC6 PE=1 SV=2,0,57.276,5,17,44,17,4857,529.9,6.05,16144,,17,,cell death;cell division;metabolic process;regulation of biological process,cytoplasm;cytoskeleton;endosome;Golgi;membrane,catalytic activity;enzyme regulator activity;protein binding,"Pf00179, Pf00653, Pf12356",57448,,BIRC6,2,Ubiquitin mediated proteolysis; Apoptosis - multiple species,,,2,High,1
Q9NVV4-2,"Isoform 2 of Poly(A) RNA polymerase, mitochondrial OS=Homo sapiens OX=9606 GN=MTPAP",0,57.272,21,11,36,10,712,78.8,8.28,14619,,11,,metabolic process,mitochondrion,catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding,Pf03828,55149,,MTPAP,10,,,,0,High,1
Q16611,Bcl-2 homologous antagonist/killer OS=Homo sapiens OX=9606 GN=BAK1 PE=1 SV=1,0,57.227,53,8,39,8,211,23.4,6.01,15408,,8,,cell death;cell organization and biogenesis;cell proliferation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;endoplasmic reticulum;membrane;mitochondrion,metal ion binding;protein binding,Pf00452,578,ENSG00000030110.12,BAK1,6,Apoptosis; MicroRNAs in cancer; Apoptosis - multiple species; Viral carcinogenesis; Platinum drug resistance; Protein processing in endoplasmic reticulum,Nanomaterial induced apoptosis; Apoptosis; Photodynamic therapy-induced HIF-1 survival signaling; Regulation of Apoptosis by Parathyroid Hormone-related Protein; Oxidative Damage; DNA Damage Response (only ATM dependent),Activation and oligomerization of BAK protein,16,High,1
Q9H7C9,Mth938 domain-containing protein OS=Homo sapiens OX=9606 GN=AAMDC PE=1 SV=1,0,57.223,63,8,177,8,122,13.3,8.46,88764,0,8,1,regulation of biological process,cytoplasm,protein binding,"Pf04430, Pf11254",28971,ENSG00000087884.14,AAMDC,11,,,,0,High,1
Q96GE9,Distal membrane-arm assembly complex protein 1 OS=Homo sapiens OX=9606 GN=DMAC1 PE=1 SV=1,0,57.197,49,4,77,4,116,12.2,9.77,35856,17.07,3,1,cell organization and biogenesis,membrane;mitochondrion,,Pf15055,90871,,C9orf123; TMEM261; DMAC1,9,,,,0,High,1
Q4VC31,Coiled-coil domain-containing protein 58 OS=Homo sapiens OX=9606 GN=CCDC58 PE=1 SV=1,0,57.106,38,4,127,4,144,16.6,7.81,67298,0,4,1,,mitochondrion,,Pf09774,131076,ENSG00000160124.9,CCDC58,3,,,,0,High,1
O14548,"Cytochrome c oxidase subunit 7A-related protein, mitochondrial OS=Homo sapiens OX=9606 GN=COX7A2L PE=1 SV=2",0,57.064,63,6,117,6,114,12.6,9.42,56274,,6,,metabolic process;transport,membrane;mitochondrion,catalytic activity;transporter activity,Pf02238,9167,ENSG00000115944.14,COX7A2L,2,Oxidative phosphorylation; Huntington's disease; Cardiac muscle contraction; Alzheimer's disease; Non-alcoholic fatty liver disease (NAFLD); Parkinson's disease,Electron Transport Chain,TP53 Regulates Metabolic Genes; Respiratory electron transport,16,High,1
P42785,Lysosomal Pro-X carboxypeptidase OS=Homo sapiens OX=9606 GN=PRCP PE=1 SV=1,0,57.053,19,7,50,7,496,55.8,7.21,25678,,7,,defense response;metabolic process;regulation of biological process;response to stimulus;transport,membrane;vacuole,catalytic activity;protein binding,"Pf00561, Pf05576, Pf05577, Pf11144, Pf12697",5547,ENSG00000137509.10,PRCP,11,Protein digestion and absorption; Renin-angiotensin system,,Intrinsic Pathway of Fibrin Clot Formation; Neutrophil degranulation,8,High,1
P53701,Cytochrome c-type heme lyase OS=Homo sapiens OX=9606 GN=HCCS PE=1 SV=1,0,57.051,37,10,64,10,268,30.6,6.68,28092,,10,,cell organization and biogenesis;metabolic process,membrane;mitochondrion,catalytic activity;metal ion binding,Pf01265,3052,ENSG00000004961.14,HCCS,X,Porphyrin and chlorophyll metabolism,,,1,High,1
Q6PKH6,Dehydrogenase/reductase SDR family member 4-like 2 OS=Homo sapiens OX=9606 GN=DHRS4L2 PE=2 SV=1,0,56.966,36,7,110,1,230,24.6,10.11,51777,,7,,metabolic process,extracellular,catalytic activity,"Pf00106, Pf08659, Pf13561",317749,,DHRS4L2,14,,,,0,High,1
P07360,Complement component C8 gamma chain OS=Homo sapiens OX=9606 GN=C8G PE=1 SV=3,0,56.963,32,4,62,4,202,22.3,8.31,24601,7.19,4,1,defense response;metabolic process;regulation of biological process;response to stimulus,extracellular,protein binding,Pf00061,733,ENSG00000176919.11,C8G,9,Systemic lupus erythematosus; Prion diseases; Complement and coagulation cascades; Amoebiasis,Complement Activation; Complement and Coagulation Cascades,Terminal pathway of complement; Regulation of Complement cascade,11,High,1
O43149,Zinc finger ZZ-type and EF-hand domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ZZEF1 PE=1 SV=6,0,56.942,7,17,54,17,2961,330.9,5.95,19745,,17,,,,metal ion binding,"Pf00569, Pf03256",23140,ENSG00000074755.14,ZZEF1,17,,,,0,High,1
Q9UQ35,Serine/arginine repetitive matrix protein 2 OS=Homo sapiens OX=9606 GN=SRRM2 PE=1 SV=2,0,56.826,6,11,46,11,2752,299.4,12.06,17452,,11,,metabolic process,nucleus;spliceosomal complex,nucleotide binding;protein binding;RNA binding,,23524,ENSG00000167978.16,SRRM2,16,,,mRNA Splicing - Major Pathway,4,High,1
O75475,PC4 and SFRS1-interacting protein OS=Homo sapiens OX=9606 GN=PSIP1 PE=1 SV=1,0,56.805,19,10,68,8,530,60.1,9.13,32438,,10,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;nucleus,DNA binding;metal ion binding;protein binding;RNA binding,"Pf00855, Pf11467",11168,ENSG00000164985.14,PSIP1,9,,,2-LTR circle formation; APOBEC3G mediated resistance to HIV-1 infection; Integration of viral DNA into host genomic DNA; Vpr-mediated nuclear import of PICs; Autointegration results in viral DNA circles,13,High,1
Q08357,Sodium-dependent phosphate transporter 2 OS=Homo sapiens OX=9606 GN=SLC20A2 PE=1 SV=1,0,56.757,18,7,29,7,652,70.3,6.54,14672,,7,,transport,membrane,receptor activity;transporter activity,Pf01384,6575,ENSG00000168575.9,SLC20A2,8,,,Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1); Sodium-coupled phosphate cotransporters,8,High,1
Q96HP0,Dedicator of cytokinesis protein 6 OS=Homo sapiens OX=9606 GN=DOCK6 PE=1 SV=3,0,56.732,8,14,31,12,2047,229.4,6.74,11693,,14,,coagulation;regulation of biological process;response to stimulus,cytoplasm;cytosol,,"Pf06920, Pf11878, Pf14429",57572,ENSG00000130158.13,DOCK6,19,,,Factors involved in megakaryocyte development and platelet production,2,High,1
Q03013,Glutathione S-transferase Mu 4 OS=Homo sapiens OX=9606 GN=GSTM4 PE=1 SV=3,0,56.701,36,9,87,3,218,25.5,5.9,40268,,9,,metabolic process,cytoplasm;cytosol,catalytic activity;protein binding,"Pf00043, Pf02798, Pf13417, Pf14497",2948,ENSG00000168765.16,GSTM4,1,Drug metabolism - cytochrome P450; Chemical carcinogenesis; Glutathione metabolism; Platinum drug resistance; Metabolism of xenobiotics by cytochrome P450,NRF2 pathway; Metapathway biotransformation,Glutathione conjugation,11,High,1
Q6NUM9,"All-trans-retinol 13,14-reductase OS=Homo sapiens OX=9606 GN=RETSAT PE=1 SV=2",0,56.64,26,13,53,13,610,66.8,8.28,19639,,13,,metabolic process,endoplasmic reticulum;membrane,catalytic activity,Pf13450,54884,ENSG00000042445.13,RETSAT,2,Retinol metabolism,Vitamin A and Carotenoid Metabolism,Signaling by GPCR; Retinoid metabolism and transport,9,High,1
P20591,Interferon-induced GTP-binding protein Mx1 OS=Homo sapiens OX=9606 GN=MX1 PE=1 SV=4,0,56.634,20,10,56,8,662,75.5,5.83,25889,,10,,cell death;cell organization and biogenesis;defense response;regulation of biological process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00350, Pf01031, Pf02212",4599,ENSG00000157601.13,MX1,21,Measles; Influenza A,,Interferon alpha/beta signaling; ISG15 antiviral mechanism,8,High,1
Q99643,"Succinate dehydrogenase cytochrome b560 subunit, mitochondrial OS=Homo sapiens OX=9606 GN=SDHC PE=1 SV=1",0,56.589,41,6,339,6,169,18.6,9.69,140605,14.49,5,3,metabolic process;transport,membrane;mitochondrion,catalytic activity;metal ion binding,Pf01127,6391,ENSG00000143252.14,SDHC,1,Parkinson's disease; Citrate cycle (TCA cycle); Oxidative phosphorylation; Huntington's disease; Metabolic pathways; Alzheimer's disease; Carbon metabolism; Non-alcoholic fatty liver disease (NAFLD),Electron Transport Chain; TCA Cycle,Respiratory electron transport; Citric acid cycle (TCA cycle),16,High,1
P01619,Immunoglobulin kappa variable 3-20 OS=Homo sapiens OX=9606 GN=IGKV3-20 PE=1 SV=2,0,56.534,51,6,103,4,116,12.5,4.96,56085,0,6,1,cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity,"Pf00047, Pf07679, Pf07686, Pf13927",28912,ENSG00000282402.1; ENSG00000239951.1,IGKV3-20,2; CHR_HG2290_PATCH,,,FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis,26,High,1
Q9UBS4,DnaJ homolog subfamily B member 11 OS=Homo sapiens OX=9606 GN=DNAJB11 PE=1 SV=1,0,56.454,26,7,48,7,358,40.5,6.18,21507,2,7,2,metabolic process;regulation of biological process,cytoplasm;endoplasmic reticulum;membrane;nucleus;organelle lumen,protein binding,"Pf00226, Pf01556",51726,ENSG00000090520.11,DNAJB11,3,Protein processing in endoplasmic reticulum,Photodynamic therapy-induced unfolded protein response,XBP1(S) activates chaperone genes,6,High,1
O15143,Actin-related protein 2/3 complex subunit 1B OS=Homo sapiens OX=9606 GN=ARPC1B PE=1 SV=3,0,56.309,22,7,54,6,372,40.9,8.35,25567,0,7,2,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol,protein binding;structural molecule activity,Pf00400,10095,ENSG00000130429.12,ARPC1B,7,Fc gamma R-mediated phagocytosis; Salmonella infection; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Regulation of actin cytoskeleton; Endocytosis,Pathogenic Escherichia coli infection; Microglia Pathogen Phagocytosis Pathway,Regulation of actin dynamics for phagocytic cup formation; EPHB-mediated forward signaling; RHO GTPases Activate WASPs and WAVEs,21,High,1
O60518,Ran-binding protein 6 OS=Homo sapiens OX=9606 GN=RANBP6 PE=1 SV=2,0,56.292,13,13,83,10,1105,124.6,5.01,38389,,13,,transport,cytoplasm;membrane;nucleus,protein binding;transporter activity,"Pf12755, Pf13513, Pf13646",26953,ENSG00000137040.9,RANBP6,9,,,,0,High,1
Q9Y6H1,Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CHCHD2 PE=1 SV=1,0,56.25,64,5,77,5,151,15.5,9.22,44453,,5,,cell organization and biogenesis;metabolic process;regulation of biological process,mitochondrion;nucleus,DNA binding;protein binding,Pf06747,51142,ENSG00000106153.12,CHCHD2,7,,,Mitochondrial protein import; Metabolism of proteins,2,High,1
P02741,C-reactive protein OS=Homo sapiens OX=9606 GN=CRP PE=1 SV=1,0,56.239,28,8,239,8,224,25,5.63,108736,0,8,1,defense response;regulation of biological process;response to stimulus,extracellular,metal ion binding;protein binding,"Pf00354, Pf13385",1401,ENSG00000132693.12,CRP,1,,Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism; Overview of nanoparticle effects; IL-6 signaling pathway,Classical antibody-mediated complement activation,11,High,1
Q96J02,E3 ubiquitin-protein ligase Itchy homolog OS=Homo sapiens OX=9606 GN=ITCH PE=1 SV=2,0,56.138,16,11,43,9,903,102.7,6.3,15071,,11,,cell death;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endosome;membrane;nucleus,catalytic activity;protein binding,"Pf00168, Pf00397, Pf00632",83737,ENSG00000078747.14,ITCH,20,Endocytosis; Ubiquitin mediated proteolysis; Non-alcoholic fatty liver disease (NAFLD); TNF signaling pathway,TGF-beta Signaling Pathway; VEGFA-VEGFR2 Signaling Pathway; EGF/EGFR Signaling Pathway; Notch Signaling Pathway,Hedgehog 'on' state; Activated NOTCH1 Transmits Signal to the Nucleus; Degradation of GLI1 by the proteasome; NOD1/2 Signaling Pathway; Negative regulators of DDX58/IFIH1 signaling; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Antigen processing: Ubiquitination & Proteasome degradation; Downregulation of ERBB4 signaling,33,High,1
Q9UDW1,Cytochrome b-c1 complex subunit 9 OS=Homo sapiens OX=9606 GN=UQCR10 PE=1 SV=3,0,56.133,52,6,557,6,63,7.3,9.47,309118,0,6,1,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion,catalytic activity;transporter activity,Pf05365,29796,ENSG00000184076.13,UQCR10,22,Metabolic pathways; Huntington's disease; Oxidative phosphorylation; Parkinson's disease; Cardiac muscle contraction; Non-alcoholic fatty liver disease (NAFLD); Alzheimer's disease,Electron Transport Chain,Respiratory electron transport,12,High,1
O15084-1,Isoform 3 of Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A OS=Homo sapiens OX=9606 GN=ANKRD28,0,55.979,12,9,46,8,1086,116.5,6.18,18467,,9,,cell organization and biogenesis,cytosol;membrane,protein binding,"Pf00023, Pf12796, Pf13606, Pf13637, Pf13857",23243,,ANKRD28,3,,,,0,High,1
P15586,N-acetylglucosamine-6-sulfatase OS=Homo sapiens OX=9606 GN=GNS PE=1 SV=3,0,55.948,26,10,63,10,552,62,8.31,25984,,10,,metabolic process;transport,extracellular;organelle lumen;vacuole,catalytic activity;metal ion binding;protein binding,"Pf00884, Pf01663",2799,ENSG00000135677.10,GNS,12,Glycosaminoglycan degradation; Lysosome; Metabolic pathways,,Neutrophil degranulation; MPS IIID - Sanfilippo syndrome D; Keratan sulfate degradation; Lysosome Vesicle Biogenesis,21,High,1
O76070,Gamma-synuclein OS=Homo sapiens OX=9606 GN=SNCG PE=1 SV=2,0,55.942,66,7,26,7,127,13.3,4.86,14711,,7,,cell communication;cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton,protein binding,Pf01387,6623,ENSG00000173267.13,SNCG,10,,,,0,High,1
O43175,D-3-phosphoglycerate dehydrogenase OS=Homo sapiens OX=9606 GN=PHGDH PE=1 SV=4,0,55.937,26,12,82,12,533,56.6,6.71,34108,,12,,metabolic process,cytosol,catalytic activity;nucleotide binding,"Pf00389, Pf02826",26227,ENSG00000092621.11,PHGDH,1,"Carbon metabolism; Metabolic pathways; Glycine, serine and threonine metabolism; Biosynthesis of amino acids",Trans-sulfuration and one carbon metabolism,Serine biosynthesis,9,High,1
P10599,Thioredoxin OS=Homo sapiens OX=9606 GN=TXN PE=1 SV=3,0,55.921,32,7,222,7,105,11.7,4.92,103279,6.82,6,2,cell communication;cell proliferation;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;mitochondrion;nucleus,antioxidant activity;catalytic activity;protein binding;RNA binding,"Pf00085, Pf00462, Pf13098, Pf13899, Pf13905",7295,ENSG00000136810.12,TXN,9,NOD-like receptor signaling pathway,Selenium Micronutrient Network; TNF alpha Signaling Pathway; NRF2 pathway; VEGFA-VEGFR2 Signaling Pathway,Interconversion of nucleotide di- and triphosphates; Protein repair; TP53 Regulates Metabolic Genes; The NLRP3 inflammasome; Oxidative Stress Induced Senescence; Detoxification of Reactive Oxygen Species,25,High,1
Q8NBJ5,Procollagen galactosyltransferase 1 OS=Homo sapiens OX=9606 GN=COLGALT1 PE=1 SV=1,0,55.903,22,13,62,13,622,71.6,7.31,27969,,13,,,endoplasmic reticulum;membrane;organelle lumen,catalytic activity,"Pf00535, Pf01755, Pf13641",79709,ENSG00000130309.10,COLGALT1; GLT25D1,19,Lysine degradation; Other types of O-glycan biosynthesis,,Collagen biosynthesis and modifying enzymes,5,High,1
Q5T653,"39S ribosomal protein L2, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL2 PE=1 SV=2",0,55.895,30,7,76,7,305,33.3,11.3,31784,0,7,2,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,catalytic activity;RNA binding;structural molecule activity,"Pf00181, Pf03947",51069,ENSG00000112651.11,MRPL2,6,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
Q14185,Dedicator of cytokinesis protein 1 OS=Homo sapiens OX=9606 GN=DOCK1 PE=1 SV=2,0,55.892,11,16,45,15,1865,215.2,7.56,14392,,16,,cell death;cell organization and biogenesis;cellular component movement;coagulation;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane,enzyme regulator activity;protein binding,"Pf00018, Pf06920, Pf07653, Pf14429, Pf14604",1793,ENSG00000150760.12,DOCK1,10,Shigellosis; Focal adhesion; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells,Integrin-mediated Cell Adhesion; Focal Adhesion; Signaling of Hepatocyte Growth Factor Receptor; Regulation of Actin Cytoskeleton,"DCC mediated attractive signaling; Regulation of actin dynamics for phagocytic cup formation; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production",25,High,1
Q9NP58,"ATP-binding cassette sub-family B member 6, mitochondrial OS=Homo sapiens OX=9606 GN=ABCB6 PE=1 SV=1",0,55.889,17,9,60,9,842,93.8,8.48,28850,,9,,cellular homeostasis;metabolic process;transport,cytosol;endoplasmic reticulum;endosome;Golgi;membrane;mitochondrion,catalytic activity;nucleotide binding;transporter activity,"Pf00005, Pf00664, Pf02463, Pf03193, Pf13304, Pf13558",10058,ENSG00000115657.12,ABCB6,2,ABC transporters,,Defective ABCB6 causes isolated colobomatous microphthalmia 7 (MCOPCB7); Mitochondrial ABC transporters,8,High,1
Q8N3C0,Activating signal cointegrator 1 complex subunit 3 OS=Homo sapiens OX=9606 GN=ASCC3 PE=1 SV=3,0,55.871,7,12,48,12,2202,251.3,7.09,17197,,12,,cell proliferation;metabolic process;regulation of biological process;response to stimulus,cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00270, Pf00271, Pf02889, Pf13401",10973,ENSG00000112249.13,ASCC3,6,,Mesodermal Commitment Pathway,ALKBH3 mediated reversal of alkylation damage,5,High,1
Q6DKK2,"Tetratricopeptide repeat protein 19, mitochondrial OS=Homo sapiens OX=9606 GN=TTC19 PE=1 SV=4",0,55.866,37,12,53,12,380,42.4,5.77,17378,19.18,11,2,cell division;cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion,protein binding,"Pf13414, Pf13424",54902,ENSG00000011295.15,TTC19,17,,,,0,High,1
Q08752,Peptidyl-prolyl cis-trans isomerase D OS=Homo sapiens OX=9606 GN=PPID PE=1 SV=3,0,55.805,34,11,68,11,370,40.7,7.21,28732,,11,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,"Pf00160, Pf00515, Pf13414, Pf13424, Pf13432, Pf14559",5481,ENSG00000171497.4,PPID,4,,,,0,High,1
Q8NI35,InaD-like protein OS=Homo sapiens OX=9606 GN=PATJ PE=1 SV=3,0,55.804,9,13,98,12,1801,196.2,4.94,35498,0,13,1,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,protein binding,"Pf00595, Pf09045, Pf13180",10207,ENSG00000132849.19,INADL; PATJ,1,Tight junction; Hippo signaling pathway,,Tight junction interactions,6,High,1
P82664,"28S ribosomal protein S10, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS10 PE=1 SV=2",0,55.799,41,6,48,6,201,23,8,23066,,6,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,,Pf00338,55173,ENSG00000048544.5,MRPS10,6,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
O43768,Alpha-endosulfine OS=Homo sapiens OX=9606 GN=ENSA PE=1 SV=1,0,55.763,66,8,95,7,121,13.4,7.24,41945,,8,,cell division;regulation of biological process;response to stimulus;transport,cytoplasm,enzyme regulator activity;protein binding,Pf04667,2029,ENSG00000143420.18,ENSA,1,,,MASTL Facilitates Mitotic Progression,5,High,1
Q96AG4,Leucine-rich repeat-containing protein 59 OS=Homo sapiens OX=9606 GN=LRRC59 PE=1 SV=1,0,55.751,34,9,76,9,307,34.9,9.57,32906,0,9,1,,endoplasmic reticulum;membrane;nucleus,protein binding;RNA binding,"Pf12799, Pf13855",55379,ENSG00000108829.9,LRRC59,17,,,,0,High,1
P19237,"Troponin I, slow skeletal muscle OS=Homo sapiens OX=9606 GN=TNNI1 PE=1 SV=3",0,55.735,27,7,301,5,187,21.7,9.58,164112,,7,,cellular component movement;regulation of biological process,cytosol,metal ion binding;protein binding,Pf00992,7135,ENSG00000159173.18,TNNI1,1,,Striated Muscle Contraction,Striated Muscle Contraction,3,High,1
P12074,"Cytochrome c oxidase subunit 6A1, mitochondrial OS=Homo sapiens OX=9606 GN=COX6A1 PE=1 SV=4",0,55.728,43,4,217,4,109,12.1,9.32,73383,6.31,4,1,metabolic process;regulation of biological process;transport,membrane;mitochondrion,catalytic activity;enzyme regulator activity;transporter activity,Pf02046,1337,ENSG00000111775.2,COX6A1,12,Parkinson's disease; Cardiac muscle contraction; Oxidative phosphorylation; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways; Alzheimer's disease,Electron Transport Chain,TP53 Regulates Metabolic Genes; Respiratory electron transport,17,High,1
Q9HB07,"UPF0160 protein MYG1, mitochondrial OS=Homo sapiens OX=9606 GN=C12orf10 PE=1 SV=2",0,55.714,36,10,56,10,376,42.4,6.67,23698,0,10,1,response to stimulus,mitochondrion;nucleus,,Pf03690,60314,ENSG00000139637.13,C12orf10,12,,,,0,High,1
Q9UIW2,Plexin-A1 OS=Homo sapiens OX=9606 GN=PLXNA1 PE=1 SV=3,0,55.699,8,13,52,10,1896,210.9,6.92,18088,,13,,cell growth;cellular component movement;development;regulation of biological process;response to stimulus,membrane,protein binding;receptor activity;signal transducer activity,"Pf01403, Pf01437, Pf01833, Pf08337",5361,ENSG00000114554.11,PLXNA1,3,Axon guidance,,SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Other semaphorin interactions; Sema3A PAK dependent Axon repulsion; CRMPs in Sema3A signaling,8,High,1
Q86X83,COMM domain-containing protein 2 OS=Homo sapiens OX=9606 GN=COMMD2 PE=1 SV=2,0,55.658,70,10,137,10,199,22.7,6.73,54212,0,10,1,metabolic process;regulation of biological process,cytoplasm,protein binding,Pf07258,51122,ENSG00000114744.8,COMMD2,3,,,Neddylation,3,High,1
P09619,Platelet-derived growth factor receptor beta OS=Homo sapiens OX=9606 GN=PDGFRB PE=1 SV=1,0,55.604,18,13,65,12,1106,123.9,4.98,26639,,13,,cell organization and biogenesis;cell proliferation;cellular component movement;development;metabolic process;regulation of biological process;response to stimulus,cell surface;cytoplasm;membrane;nucleus;organelle lumen;vacuole,catalytic activity;nucleotide binding;protein binding;receptor activity;signal transducer activity;structural molecule activity,"Pf00047, Pf00069, Pf07679, Pf07714, Pf13895, Pf13927",5159,ENSG00000113721.13,PDGFRB,5,MicroRNAs in cancer; Calcium signaling pathway; Focal adhesion; Glioma; Rap1 signaling pathway; Regulation of actin cytoskeleton; EGFR tyrosine kinase inhibitor resistance; Pathways in cancer; Phospholipase D signaling pathway; PI3K-Akt signaling pathway; Gap junction; Central carbon metabolism in cancer; Ras signaling pathway; Prostate cancer; Choline metabolism in cancer; MAPK signaling pathway; HTLV-I infection; Cytokine-cytokine receptor interaction; Melanoma,Signaling Pathways in Glioblastoma; PDGF Pathway; Focal Adhesion; Osteoblast Signaling; Imatinib and Chronic Myeloid Leukemia; MAPK Signaling Pathway; ESC Pluripotency Pathways; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Regulation of Actin Cytoskeleton,"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Constitutive Signaling by Aberrant PI3K in Cancer; RAF/MAP kinase cascade; Downstream signal transduction; Interleukin-20 family signaling",47,High,1
P09936,Ubiquitin carboxyl-terminal hydrolase isozyme L1 OS=Homo sapiens OX=9606 GN=UCHL1 PE=1 SV=2,0,55.527,35,6,96,6,223,24.8,5.48,42573,,6,,cell communication;cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;membrane,catalytic activity;protein binding,Pf01088,7345,ENSG00000154277.12,UCHL1,4,Parkinson's disease,Proteasome Degradation; Parkinsons Disease Pathway; Hepatitis C and Hepatocellular Carcinoma,UCH proteinases,8,High,1
Q8N2K0,Lysophosphatidylserine lipase ABHD12 OS=Homo sapiens OX=9606 GN=ABHD12 PE=1 SV=2,0,55.512,39,11,43,11,398,45.1,8.65,18211,,11,,metabolic process;response to stimulus,cytoplasm;membrane,catalytic activity,"Pf00326, Pf00561, Pf12695, Pf12697",26090,ENSG00000100997.18,ABHD12,20,,,Arachidonate production from DAG; Gastrin-CREB signalling pathway via PKC and MAPK,9,High,1
P04066,Tissue alpha-L-fucosidase OS=Homo sapiens OX=9606 GN=FUCA1 PE=1 SV=4,0,55.488,31,10,75,10,466,53.7,6.84,33445,,10,,metabolic process;transport,cytoplasm;extracellular;organelle lumen;vacuole,catalytic activity,Pf01120,2517,ENSG00000179163.11,FUCA1,1,Lysosome; Other glycan degradation,,Neutrophil degranulation; Reactions specific to the complex N-glycan synthesis pathway,11,High,1
Q9H7D0,Dedicator of cytokinesis protein 5 OS=Homo sapiens OX=9606 GN=DOCK5 PE=1 SV=3,0,55.478,9,11,32,10,1870,215.2,7.96,12990,,11,,regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,protein binding,"Pf00018, Pf06920, Pf07653, Pf14429, Pf14604",80005,ENSG00000147459.17,DOCK5,8,,,Factors involved in megakaryocyte development and platelet production,2,High,1
Q08945,FACT complex subunit SSRP1 OS=Homo sapiens OX=9606 GN=SSRP1 PE=1 SV=1,0,55.431,19,12,94,12,709,81,6.87,34389,,12,,metabolic process;regulation of biological process;response to stimulus,chromosome;nucleus,DNA binding;protein binding;RNA binding,"Pf00505, Pf03531, Pf08512, Pf09011",6749,ENSG00000149136.8,SSRP1,11,,,HIV elongation arrest and recovery; TP53 Regulates Transcription of DNA Repair Genes; Tat-mediated HIV elongation arrest and recovery; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; Pausing and recovery of HIV elongation; Pausing and recovery of Tat-mediated HIV elongation; Formation of HIV-1 elongation complex containing HIV-1 Tat,24,High,1
O43684,Mitotic checkpoint protein BUB3 OS=Homo sapiens OX=9606 GN=BUB3 PE=1 SV=1,0,55.388,31,8,54,8,328,37.1,6.84,24753,,8,,cell division;cell organization and biogenesis;metabolic process;regulation of biological process,chromosome;cytosol;nucleus,protein binding,"Pf00400, Pf04762",9184,ENSG00000154473.17,BUB3,10,HTLV-I infection; Cell cycle,Cell Cycle,Inactivation of APC/C via direct inhibition of the APC/C complex; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; APC-Cdc20 mediated degradation of Nek2A,29,High,1
Q969V5,Mitochondrial ubiquitin ligase activator of NFKB 1 OS=Homo sapiens OX=9606 GN=MUL1 PE=1 SV=1,0,55.23,30,6,49,6,352,39.8,8.13,15972,19.36,5,2,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,membrane;mitochondrion,catalytic activity;metal ion binding;protein binding;signal transducer activity,"Pf12483, Pf13639, Pf13920, Pf13923, Pf14634",79594,ENSG00000090432.6,MUL1,1,,,Ub-specific processing proteases,4,High,1
Q7KZN9,Cytochrome c oxidase assembly protein COX15 homolog OS=Homo sapiens OX=9606 GN=COX15 PE=1 SV=1,0,55.215,22,8,65,8,410,46,9.82,25831,0,8,1,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion;nucleus,catalytic activity;transporter activity,Pf02628,1355,ENSG00000014919.12,COX15,10,Porphyrin and chlorophyll metabolism; Metabolic pathways; Oxidative phosphorylation,Electron Transport Chain,Heme biosynthesis,7,High,1
Q15126,Phosphomevalonate kinase OS=Homo sapiens OX=9606 GN=PMVK PE=1 SV=3,0,55.131,46,9,77,9,192,22,5.73,37639,,9,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;nucleotide binding,Pf04275,10654,ENSG00000163344.5,PMVK,1,Peroxisome; Metabolic pathways; Terpenoid backbone biosynthesis,Cholesterol Biosynthesis,Cholesterol biosynthesis; Activation of gene expression by SREBF (SREBP),10,High,1
O43293,Death-associated protein kinase 3 OS=Homo sapiens OX=9606 GN=DAPK3 PE=1 SV=1,0,55.105,29,10,58,10,454,52.5,6.89,21984,0,10,1,cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;membrane;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf07714",1613,ENSG00000167657.13,DAPK3,19,Pathways in cancer; Bladder cancer,Bladder Cancer,Ligand-independent caspase activation via DCC,7,High,1
Q86TV6,Tetratricopeptide repeat protein 7B OS=Homo sapiens OX=9606 GN=TTC7B PE=1 SV=3,0,55.089,17,11,51,11,843,94.1,6.89,18197,,11,,cell organization and biogenesis;metabolic process,cytoplasm;cytosol;membrane,protein binding,"Pf07719, Pf13414, Pf13424, Pf13432, Pf14559",145567,ENSG00000165914.14,TTC7B,14,,,,0,High,1
P01599,Immunoglobulin kappa variable 1-17 OS=Homo sapiens OX=9606 GN=IGKV1-17 PE=1 SV=2,0,55.065,37,8,58,1,117,12.8,8.68,30706,,8,,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity,"Pf00047, Pf07679, Pf07686, Pf13927",28937,ENSG00000281978.1; ENSG00000240382.3,IGKV1-17,2; CHR_HG2290_PATCH,,,FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis,26,High,1
Q03518,Antigen peptide transporter 1 OS=Homo sapiens OX=9606 GN=TAP1 PE=1 SV=2,0,55.04,22,9,31,8,808,87.2,8.02,15045,,9,,defense response;response to stimulus;transport,endoplasmic reticulum;membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding;transporter activity,"Pf00005, Pf00664, Pf13304, Pf13476",6890,ENSG00000232367.5; ENSG00000227816.4; ENSG00000226173.4; ENSG00000230705.4; ENSG00000168394.10; ENSG00000206297.7; ENSG00000224212.4,TAP1,6; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_APD_CTG1; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_DBB_CTG1,Phagosome; ABC transporters; Primary immunodeficiency; Herpes simplex infection; Antigen processing and presentation,Mecp2 and Associated Rett Syndrome; Type II interferon signaling (IFNG),"ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC",13,High,1
O43920,NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 OS=Homo sapiens OX=9606 GN=NDUFS5 PE=1 SV=3,0,55.006,35,7,514,7,106,12.5,9.14,265866,0,7,1,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion,catalytic activity,Pf10200,4725,ENSG00000168653.10,NDUFS5,1,Non-alcoholic fatty liver disease (NAFLD); Parkinson's disease; Oxidative phosphorylation; Huntington's disease; Metabolic pathways; Alzheimer's disease,Electron Transport Chain; Oxidative phosphorylation,Complex I biogenesis,13,High,1
P49406,"39S ribosomal protein L19, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL19 PE=1 SV=2",0,54.967,42,10,90,10,292,33.5,9.5,45539,0,10,1,cell organization and biogenesis;metabolic process,membrane;mitochondrion;nucleus;ribosome,structural molecule activity,Pf01245,9801,ENSG00000115364.13,MRPL19,2,Ribosome,Cytoplasmic Ribosomal Proteins,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,8,High,1
Q92878,DNA repair protein RAD50 OS=Homo sapiens OX=9606 GN=RAD50 PE=1 SV=1,0,54.847,12,14,40,14,1312,153.8,6.89,15423,0,14,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;membrane;nucleus,catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding,"Pf02463, Pf04423, Pf13304, Pf13476, Pf13514, Pf13555, Pf13558",10111,ENSG00000113522.13,RAD50,5,Homologous recombination; Non-homologous end-joining,miRNA Regulation of DNA Damage Response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM Signaling Network in Development and Disease; Non-homologous end joining; DNA Damage Response,G2/M DNA damage checkpoint; Presynaptic phase of homologous DNA pairing and strand exchange; Nonhomologous End-Joining (NHEJ); Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Meiotic recombination; Sensing of DNA Double Strand Breaks; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); HDR through MMEJ (alt-NHEJ); DNA Damage/Telomere Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; Resolution of D-loop Structures through Holliday Junction Intermediates,42,High,1
Q5BKX8,Caveolae-associated protein 4 OS=Homo sapiens OX=9606 GN=CAVIN4 PE=1 SV=2,0,54.78,23,7,142,7,364,41.9,8.28,54092,24.28,6,3,cell differentiation;development;metabolic process;regulation of biological process,cytoplasm;cytosol;membrane,protein binding,Pf15237,347273,ENSG00000170681.6,MURC; CAVIN4,9,,,,0,High,1
Q9Y2T2,AP-3 complex subunit mu-1 OS=Homo sapiens OX=9606 GN=AP3M1 PE=1 SV=1,0,54.752,32,9,66,7,418,46.9,6.93,24748,,9,,cellular component movement;transport,Golgi;membrane;vacuole,protein binding,"Pf00928, Pf01217",26985,ENSG00000185009.12,AP3M1,10,Lysosome,,Association of TriC/CCT with target proteins during biosynthesis,5,High,1
Q96RF0,Sorting nexin-18 OS=Homo sapiens OX=9606 GN=SNX18 PE=1 SV=2,0,54.748,17,9,81,9,628,68.9,5.68,33229,0,9,1,cell division;metabolic process;regulation of biological process;transport,endosome;membrane,catalytic activity;protein binding,"Pf00018, Pf00787, Pf03894, Pf07653, Pf10456, Pf14604",112574,ENSG00000178996.13,SNX18,5,,,Clathrin-mediated endocytosis,3,High,1
P05543,Thyroxine-binding globulin OS=Homo sapiens OX=9606 GN=SERPINA7 PE=1 SV=2,0,54.719,37,11,112,9,415,46.3,6.3,53059,0,11,1,regulation of biological process;transport,extracellular,enzyme regulator activity,Pf00079,6906,ENSG00000123561.14,SERPINA7,X,Thyroid hormone synthesis,,,1,High,1
Q9H425,Uncharacterized protein C1orf198 OS=Homo sapiens OX=9606 GN=C1orf198 PE=1 SV=1,0,54.711,48,13,51,13,327,36.3,5.72,21986,,13,,,cytoplasm;cytosol,,,84886,ENSG00000119280.16,C1orf198,1,,,,0,High,1
Q9NZQ3,NCK-interacting protein with SH3 domain OS=Homo sapiens OX=9606 GN=NCKIPSD PE=1 SV=1,0,54.709,16,9,36,9,722,78.9,6.38,14556,,9,,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytosol;nucleus,protein binding,"Pf00018, Pf07653, Pf09431, Pf14604",51517,ENSG00000213672.7,NCKIPSD,3,,,Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs,8,High,1
Q9H3N1,Thioredoxin-related transmembrane protein 1 OS=Homo sapiens OX=9606 GN=TMX1 PE=1 SV=1,0,54.597,30,10,54,10,280,31.8,4.98,22234,,10,,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;membrane,catalytic activity,"Pf00085, Pf13098",81542,ENSG00000139921.12,TMX1,14,,,,0,High,1
Q8WW12,PEST proteolytic signal-containing nuclear protein OS=Homo sapiens OX=9606 GN=PCNP PE=1 SV=2,0,54.594,31,5,64,5,178,18.9,7.49,34411,,5,,metabolic process,nucleus,protein binding,Pf15473,57092,ENSG00000081154.11,PCNP,3,,,,0,High,1
Q14318,Peptidyl-prolyl cis-trans isomerase FKBP8 OS=Homo sapiens OX=9606 GN=FKBP8 PE=1 SV=2,0,54.528,23,7,85,7,412,44.5,4.84,32659,,7,,cell death;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;membrane;mitochondrion,catalytic activity;metal ion binding;protein binding,"Pf00254, Pf00515, Pf07719, Pf13181, Pf13414, Pf13424, Pf13432, Pf14559",23770,ENSG00000105701.15,FKBP8,19,,Senescence and Autophagy in Cancer,Ub-specific processing proteases,5,High,1
Q9HD20,Manganese-transporting ATPase 13A1 OS=Homo sapiens OX=9606 GN=ATP13A1 PE=1 SV=2,0,54.467,12,13,158,13,1204,132.9,8.13,56489,0,13,1,cellular homeostasis;transport,endoplasmic reticulum;membrane,catalytic activity;metal ion binding;nucleotide binding;transporter activity,"Pf00122, Pf00702, Pf12710, Pf13246",57130,ENSG00000105726.16,ATP13A1,19,,,Ion transport by P-type ATPases,3,High,1
P60953,Cell division control protein 42 homolog OS=Homo sapiens OX=9606 GN=CDC42 PE=1 SV=2,0,54.423,25,5,175,5,191,21.2,6.55,80417,4,4,1,cell communication;cell differentiation;cell division;cell organization and biogenesis;cellular component movement;coagulation;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane;vacuole,catalytic activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf08477",998,ENSG00000070831.15,CDC42,1,MAPK signaling pathway; Non-alcoholic fatty liver disease (NAFLD); Neurotrophin signaling pathway; Adherens junction; Shigellosis; Tight junction; Focal adhesion; Epithelial cell signaling in Helicobacter pylori infection; Viral carcinogenesis; Pathways in cancer; Ras signaling pathway; VEGF signaling pathway; Leukocyte transendothelial migration; Pathogenic Escherichia coli infection; Salmonella infection; Axon guidance; Endocytosis; Renal cell carcinoma; GnRH signaling pathway; Bacterial invasion of epithelial cells; Regulation of actin cytoskeleton; Proteoglycans in cancer; AGE-RAGE signaling pathway in diabetic complications; Rap1 signaling pathway; Pancreatic cancer; T cell receptor signaling pathway; Chemokine signaling pathway; Fc gamma R-mediated phagocytosis,Androgen receptor signaling pathway; Target Of Rapamycin (TOR) Signaling; Integrin-mediated Cell Adhesion; Integrated Breast Cancer Pathway; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; Leptin signaling pathway; Regulation of Microtubule Cytoskeleton; Metastatic brain tumor; Pathogenic Escherichia coli infection; RalA downstream regulated genes; B Cell Receptor Signaling Pathway; AGE/RAGE pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Spinal Cord Injury; Focal Adhesion; TGF-beta Signaling Pathway; MAPK Signaling Pathway; VEGFA-VEGFR2 Signaling Pathway; Chemokine signaling pathway; Oxidative Damage; p38 MAPK Signaling Pathway; EGF/EGFR Signaling Pathway; Regulation of Actin Cytoskeleton; G13 Signaling Pathway; T-Cell antigen Receptor (TCR)  Signaling Pathway; DNA Damage Response (only ATM dependent),RHO GTPases activate PAKs; G alpha (12/13) signalling events; DCC mediated attractive signaling; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; RHO GTPases activate KTN1; Rho GTPase cycle; VEGFA-VEGFR2 Pathway; EGFR downregulation; RHO GTPases activate IQGAPs; Factors involved in megakaryocyte development and platelet production; CDO in myogenesis; EPHB-mediated forward signaling; Inactivation of CDC42 and RAC1; CD28 dependent Vav1 pathway; GPVI-mediated activation cascade; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate WASPs and WAVEs; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate Formins; MAPK6/MAPK4 signaling; Interleukin-12 family signaling,102,High,1
O43294,Transforming growth factor beta-1-induced transcript 1 protein OS=Homo sapiens OX=9606 GN=TGFB1I1 PE=1 SV=2,0,54.411,22,7,51,7,461,49.8,7.03,28454,,7,,cell differentiation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;nucleus,metal ion binding;protein binding,Pf00412,7041,ENSG00000140682.18,TGFB1I1,16,,Androgen receptor signaling pathway; Serotonin Transporter Activity; TGF-beta Signaling Pathway; Monoamine Transport,,4,High,1
Q07812,Apoptosis regulator BAX OS=Homo sapiens OX=9606 GN=BAX PE=1 SV=1,0,54.401,41,7,46,7,192,21.2,5.22,24251,0,7,1,cell death;cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;membrane;mitochondrion;nucleus,protein binding;transporter activity,Pf00452,581,ENSG00000087088.19,BAX,19,EGFR tyrosine kinase inhibitor resistance; Protein processing in endoplasmic reticulum; Hepatitis B; Endocrine resistance; p53 signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Colorectal cancer; Viral carcinogenesis; Sphingolipid signaling pathway; HTLV-I infection; Neurotrophin signaling pathway; Longevity regulating pathway; Tuberculosis; Prion diseases; Amyotrophic lateral sclerosis (ALS); Apoptosis - multiple species; Non-alcoholic fatty liver disease (NAFLD); Pathways in cancer; Apoptosis; Huntington's disease; Platinum drug resistance,miRNA Regulation of DNA Damage Response; TP53 Network; Integrated Breast Cancer Pathway; Leptin signaling pathway; TNF alpha Signaling Pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Aryl Hydrocarbon Receptor Pathway; Overview of nanoparticle effects; Rac1/Pak1/p38/MMP-2 pathway; Photodynamic therapy-induced HIF-1 survival signaling; Regulation of Apoptosis by Parathyroid Hormone-related Protein; DNA Damage Response; DNA Damage Response (only ATM dependent),"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Activation, translocation and oligomerization of BAX; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; Transcriptional regulation by RUNX2",49,High,1
Q7Z2W9,"39S ribosomal protein L21, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL21 PE=1 SV=2",0,54.391,42,9,83,9,205,22.8,9.89,30614,0,9,1,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,RNA binding;structural molecule activity,Pf00829,219927,ENSG00000197345.12,MRPL21,11,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
Q8TEQ6,Gem-associated protein 5 OS=Homo sapiens OX=9606 GN=GEMIN5 PE=1 SV=3,0,54.381,8,11,44,11,1508,168.5,6.62,16309,,11,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;membrane;nucleus,protein binding;RNA binding,Pf00400,25929,ENSG00000082516.8,GEMIN5,5,RNA transport,,snRNP Assembly,4,High,1
Q5VZ89,DENN domain-containing protein 4C OS=Homo sapiens OX=9606 GN=DENND4C PE=1 SV=3,0,54.362,9,14,40,14,1909,212.6,6.83,16115,,14,,cell organization and biogenesis;response to stimulus;transport,cytoplasm;cytosol;membrane,,"Pf02141, Pf03455, Pf03456, Pf13041",55667,ENSG00000137145.20,DENND4C,9,,,RAB GEFs exchange GTP for GDP on RABs,4,High,1
O43896,Kinesin-like protein KIF1C OS=Homo sapiens OX=9606 GN=KIF1C PE=1 SV=3,0,54.358,13,13,49,8,1103,122.9,6.9,18005,5.16,13,1,cellular component movement;transport,cytoplasm;cytoskeleton;endoplasmic reticulum;Golgi,catalytic activity;motor activity;nucleotide binding;protein binding;RNA binding,"Pf00225, Pf00498",10749,ENSG00000129250.11,KIF1C,17,,,COPI-dependent Golgi-to-ER retrograde traffic; Kinesins,8,High,1
Q96ED9,Protein Hook homolog 2 OS=Homo sapiens OX=9606 GN=HOOK2 PE=1 SV=3,0,54.311,18,9,49,9,719,83.2,5.47,20390,0,9,1,cell organization and biogenesis;transport,cytoplasm;cytoskeleton;cytosol,protein binding,Pf05622,29911,ENSG00000095066.11,HOOK2,19,,,,0,High,1
Q7Z392,Trafficking protein particle complex subunit 11 OS=Homo sapiens OX=9606 GN=TRAPPC11 PE=1 SV=2,0,54.289,11,10,45,10,1133,128.8,7.14,15972,0,10,1,cell organization and biogenesis;transport,cytosol;Golgi,protein binding,"Pf07919, Pf11817, Pf12742",60684,ENSG00000168538.15,TRAPPC11,4,,,RAB GEFs exchange GTP for GDP on RABs,4,High,1
Q86TW2,AarF domain-containing protein kinase 1 OS=Homo sapiens OX=9606 GN=ADCK1 PE=1 SV=2,0,54.253,27,9,43,9,530,60.5,8.6,17158,,9,,metabolic process,extracellular,catalytic activity;enzyme regulator activity;nucleotide binding;receptor activity;signal transducer activity,Pf03109,57143,,ADCK1,14,,,,0,High,1
Q7Z2Z2,Elongation factor-like GTPase 1 OS=Homo sapiens OX=9606 GN=EFL1 PE=1 SV=2,0,54.247,11,12,83,12,1120,125.4,5.91,34531,0,11,1,cell organization and biogenesis;metabolic process,,catalytic activity;nucleotide binding;RNA binding,"Pf00009, Pf00679, Pf01926, Pf03764, Pf14492",79631,ENSG00000140598.13,EFTUD1; EFL1,15,Ribosome biogenesis in eukaryotes,,,1,High,1
Q6H8Q1,Actin-binding LIM protein 2 OS=Homo sapiens OX=9606 GN=ABLIM2 PE=1 SV=2,0,54.241,20,9,34,8,611,67.8,7.94,16211,,9,,cell organization and biogenesis;metabolic process,cytoplasm;cytoskeleton,metal ion binding;protein binding,"Pf00412, Pf02209",84448,ENSG00000163995.19,ABLIM2,4,Axon guidance,,DCC mediated attractive signaling,5,High,1
P37235,Hippocalcin-like protein 1 OS=Homo sapiens OX=9606 GN=HPCAL1 PE=1 SV=3,0,54.219,49,8,77,6,193,22.3,5.35,36052,,8,,,membrane,metal ion binding;protein binding,"Pf00036, Pf13202, Pf13405, Pf13499, Pf13833",3241,ENSG00000115756.12,HPCAL1,2,,,,0,High,1
P37840,Alpha-synuclein OS=Homo sapiens OX=9606 GN=SNCA PE=1 SV=1,0,54.179,41,4,53,4,140,14.5,4.7,26899,0,4,1,cell communication;cell death;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;extracellular;Golgi;membrane;mitochondrion;nucleus;ribosome;vacuole,catalytic activity;DNA binding;enzyme regulator activity;metal ion binding;protein binding;transporter activity,Pf01387,6622,ENSG00000145335.15,SNCA,4,Parkinson's disease; Alzheimer's disease,Alzheimers Disease; Parkin-Ubiquitin Proteasomal System pathway; Parkinsons Disease Pathway; Ectoderm Differentiation,Amyloid fiber formation,8,High,1
Q9H2K0,"Translation initiation factor IF-3, mitochondrial OS=Homo sapiens OX=9606 GN=MTIF3 PE=1 SV=4",0,54.166,22,5,103,5,278,31.7,9.69,40832,,5,,cell organization and biogenesis;metabolic process,mitochondrion,protein binding;RNA binding,"Pf00707, Pf05198",219402,ENSG00000122033.14,MTIF3,13,,,Mitochondrial translation initiation,4,High,1
P05186,"Alkaline phosphatase, tissue-nonspecific isozyme OS=Homo sapiens OX=9606 GN=ALPL PE=1 SV=4",0,54.159,27,10,30,10,524,57.3,6.67,12809,,10,,cell differentiation;metabolic process;response to stimulus,extracellular;membrane,catalytic activity;metal ion binding;protein binding,Pf00245,249,ENSG00000162551.13,ALPL,1,Metabolic pathways; Thiamine metabolism; Folate biosynthesis,AGE/RAGE pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; NOTCH1 regulation of human endothelial cell calcification; Role of Osx and miRNAs in tooth development; Endochondral Ossification,Post-translational modification: synthesis of GPI-anchored proteins,11,High,1
Q15370,Elongin-B OS=Homo sapiens OX=9606 GN=ELOB PE=1 SV=1,0,54.158,57,8,139,8,118,13.1,4.88,66496,7.5,7,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytosol;nucleus,protein binding,Pf00240,6923,ENSG00000103363.14,TCEB2; ELOB,16,Ubiquitin mediated proteolysis; Pathways in cancer; HIF-1 signaling pathway; Renal cell carcinoma,Dual hijack model of Vif in HIV infection,Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Tat-mediated HIV elongation arrest and recovery; Vif-mediated degradation of APOBEC3G; Pausing and recovery of HIV elongation; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Formation of HIV-1 elongation complex containing HIV-1 Tat; HIV elongation arrest and recovery; TP53 Regulates Transcription of DNA Repair Genes; Regulation of expression of SLITs and ROBOs; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; Formation of HIV elongation complex in the absence of HIV Tat; Pausing and recovery of Tat-mediated HIV elongation,45,High,1
Q9Y2V2,Calcium-regulated heat-stable protein 1 OS=Homo sapiens OX=9606 GN=CARHSP1 PE=1 SV=2,0,54.127,67,5,45,5,147,15.9,8.21,25181,,5,,regulation of biological process;response to stimulus,cytoplasm;cytosol,DNA binding;protein binding;RNA binding,Pf00313,23589,ENSG00000153048.10,CARHSP1,16,,,,0,High,1
Q16204,Coiled-coil domain-containing protein 6 OS=Homo sapiens OX=9606 GN=CCDC6 PE=1 SV=2,0,54.078,25,10,40,10,474,53.3,7.34,18182,,10,,cell organization and biogenesis;metabolic process,cytoplasm;cytoskeleton;cytosol,protein binding;structural molecule activity,"Pf04111, Pf09755",8030,ENSG00000108091.10,CCDC6,10,Pathways in cancer; Thyroid cancer,Retinoblastoma (RB) in Cancer; Mesodermal Commitment Pathway,,4,High,1
Q9Y394,Dehydrogenase/reductase SDR family member 7 OS=Homo sapiens OX=9606 GN=DHRS7 PE=1 SV=1,0,54.042,24,7,101,7,339,38.3,8.32,49306,,7,,metabolic process,membrane,catalytic activity,"Pf00106, Pf08659, Pf13561",51635,ENSG00000100612.13,DHRS7,14,,,,0,High,1
Q9UJY1,Heat shock protein beta-8 OS=Homo sapiens OX=9606 GN=HSPB8 PE=1 SV=1,0,54.013,41,7,202,7,196,21.6,5.12,87933,14.07,6,2,regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,Pf00011,26353,ENSG00000152137.6,HSPB8,12,,,HSF1-dependent transactivation,4,High,1
O75832,26S proteasome non-ATPase regulatory subunit 10 OS=Homo sapiens OX=9606 GN=PSMD10 PE=1 SV=1,0,54.008,39,9,64,9,226,24.4,6.1,32436,,9,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;nucleus;proteasome,protein binding,"Pf00023, Pf12796, Pf13606, Pf13637, Pf13857",5716,ENSG00000101843.18,PSMD10,X,,Proteasome Degradation; Parkin-Ubiquitin Proteasomal System pathway,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,150,High,1
O43765,Small glutamine-rich tetratricopeptide repeat-containing protein alpha OS=Homo sapiens OX=9606 GN=SGTA PE=1 SV=1,0,53.997,25,8,114,8,313,34,4.87,47965,,8,,metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;nucleus,protein binding,"Pf00515, Pf07719, Pf13181, Pf13414, Pf13424, Pf13431, Pf13432, Pf14559",6449,ENSG00000104969.9,SGTA,19,,,,0,High,1
Q06787,Synaptic functional regulator FMR1 OS=Homo sapiens OX=9606 GN=FMR1 PE=1 SV=1,0,53.988,17,9,65,7,632,71.1,7.42,27397,,9,,metabolic process;regulation of biological process;response to stimulus;transport,chromosome;cytoplasm;cytosol;membrane;nucleus;ribosome,protein binding;RNA binding;translation regulator activity,"Pf00013, Pf05641, Pf12235, Pf13014",2332,ENSG00000102081.13,FMR1,X,RNA transport,Serotonin and anxiety,,2,High,1
O14531,Dihydropyrimidinase-related protein 4 OS=Homo sapiens OX=9606 GN=DPYSL4 PE=1 SV=2,0,53.963,25,10,53,9,572,61.8,7.09,19760,,10,,cell death;cellular component movement,cytoplasm;cytosol,catalytic activity;protein binding,"Pf01979, Pf07969, Pf13147, Pf13594",10570,ENSG00000151640.12,DPYSL4,10,,,CRMPs in Sema3A signaling,4,High,1
O95319,CUGBP Elav-like family member 2 OS=Homo sapiens OX=9606 GN=CELF2 PE=1 SV=1,0,53.959,12,5,49,5,508,54.3,8.76,24687,,5,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;nucleus,RNA binding,"Pf00076, Pf13893, Pf14259",10659,ENSG00000048740.18,CELF2,10,,mRNA Processing,,1,High,1
P02760,Protein AMBP OS=Homo sapiens OX=9606 GN=AMBP PE=1 SV=1,0,53.93,26,8,94,8,352,39,6.25,45391,7.01,6,2,metabolic process;regulation of biological process;transport,cell surface;extracellular;membrane,enzyme regulator activity;protein binding,"Pf00014, Pf00061",259,ENSG00000106927.11,AMBP,9,,,Scavenging of heme from plasma,3,High,1
P23497,Nuclear autoantigen Sp-100 OS=Homo sapiens OX=9606 GN=SP100 PE=1 SV=3,0,53.924,14,12,63,12,879,100.4,8.22,27707,,12,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,DNA binding;protein binding,"Pf00505, Pf01342, Pf03172, Pf09011",6672,ENSG00000067066.16,SP100,2,Herpes simplex infection; Viral carcinogenesis,,SUMOylation of DNA damage response and repair proteins; Interferon gamma signaling,11,High,1
P19623,Spermidine synthase OS=Homo sapiens OX=9606 GN=SRM PE=1 SV=1,0,53.901,33,7,65,7,302,33.8,5.49,32563,,7,,metabolic process,cytosol,catalytic activity;protein binding,Pf01564,6723,ENSG00000116649.9,SRM,1,Glutathione metabolism; Cysteine and methionine metabolism; beta-Alanine metabolism; Arginine and proline metabolism; Metabolic pathways,Amino Acid metabolism; Nucleotide Metabolism; Urea cycle and metabolism of amino groups,Metabolism of polyamines,11,High,1
Q9NX20,"39S ribosomal protein L16, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL16 PE=1 SV=1",0,53.877,30,7,113,7,251,28.4,10.13,52583,,7,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,RNA binding;structural molecule activity,Pf00252,54948,ENSG00000166902.4,MRPL16,11,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
Q9UPR0,Inactive phospholipase C-like protein 2 OS=Homo sapiens OX=9606 GN=PLCL2 PE=1 SV=2,0,53.713,11,10,96,8,1127,125.8,6.9,32680,5.41,9,2,cell differentiation;cell proliferation;metabolic process;regulation of biological process;response to stimulus,cytoplasm,catalytic activity;protein binding;signal transducer activity,"Pf00168, Pf00169, Pf00387, Pf00388, Pf09279, Pf12814",23228,ENSG00000154822.17; ENSG00000284017.1,PLCL2,3; CHR_HG2236_PATCH,,,,0,High,1
O95372,Acyl-protein thioesterase 2 OS=Homo sapiens OX=9606 GN=LYPLA2 PE=1 SV=1,0,53.7,42,7,120,7,231,24.7,7.23,52119,14.2,6,2,cellular component movement;metabolic process,cytoplasm;cytosol,catalytic activity;protein binding,"Pf00561, Pf02230, Pf03959, Pf07859, Pf12695, Pf12697",11313,ENSG00000011009.10,LYPLA2,1,Glycerophospholipid metabolism,,L1CAM interactions,4,High,1
Q6JBY9,CapZ-interacting protein OS=Homo sapiens OX=9606 GN=RCSD1 PE=1 SV=1,0,53.674,31,8,53,8,416,44.5,5.4,20960,,8,,response to stimulus,,protein binding,"Pf05177, Pf15255",92241,ENSG00000198771.10,RCSD1,1,,,,0,High,1
P55789,FAD-linked sulfhydryl oxidase ALR OS=Homo sapiens OX=9606 GN=GFER PE=1 SV=2,0,53.619,25,5,36,5,205,23.4,7.62,20507,,5,,metabolic process;regulation of biological process,cytoplasm;cytosol;extracellular;mitochondrion,catalytic activity;nucleotide binding;protein binding,Pf04777,2671,ENSG00000127554.12,GFER,16,,,Mitochondrial protein import; Metabolism of proteins,2,High,1
P09914,Interferon-induced protein with tetratricopeptide repeats 1 OS=Homo sapiens OX=9606 GN=IFIT1 PE=1 SV=2,0,53.584,23,9,47,9,478,55.3,7.2,19827,,9,,defense response;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol,protein binding;RNA binding,"Pf00515, Pf13176, Pf13424, Pf14559",3434,ENSG00000185745.9,IFIT1,10,Herpes simplex infection; Hepatitis C,,Interferon alpha/beta signaling; ISG15 antiviral mechanism,8,High,1
Q9Y6W5,Wiskott-Aldrich syndrome protein family member 2 OS=Homo sapiens OX=9606 GN=WASF2 PE=1 SV=3,0,53.56,20,8,41,8,498,54.3,5.53,18191,,8,,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endosome,protein binding,,10163,ENSG00000158195.10,WASF2,1,Fc gamma R-mediated phagocytosis; Choline metabolism in cancer; Regulation of actin cytoskeleton; Salmonella infection; Shigellosis; Bacterial invasion of epithelial cells; Adherens junction,Regulation of Actin Cytoskeleton,Regulation of actin dynamics for phagocytic cup formation; VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs,19,High,1
Q9NRG7,Epimerase family protein SDR39U1 OS=Homo sapiens OX=9606 GN=SDR39U1 PE=1 SV=3,0,53.553,25,7,119,7,293,31.1,9.04,50144,1.66,7,2,,,,,,,,,,,,0,High,1
P42892,Endothelin-converting enzyme 1 OS=Homo sapiens OX=9606 GN=ECE1 PE=1 SV=2,0,53.551,16,8,34,8,770,87.1,5.88,13841,,8,,metabolic process;regulation of biological process,endosome;membrane,catalytic activity;metal ion binding;protein binding,"Pf01431, Pf05649",1889,ENSG00000117298.14,ECE1,1,,Endothelin Pathways; Corticotropin-releasing hormone signaling pathway; Melatonin metabolism and effects; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,Peptide ligand-binding receptors,9,High,1
Q96PC5,Melanoma inhibitory activity protein 2 OS=Homo sapiens OX=9606 GN=MIA2 PE=1 SV=4,0,53.546,8,10,53,10,1412,159.7,4.69,17941,2.38,9,1,cell organization and biogenesis;metabolic process;regulation of biological process;transport,endoplasmic reticulum;membrane,enzyme regulator activity;protein binding;transporter activity,"Pf04111, Pf04156, Pf05010, Pf06409, Pf07653, Pf07798, Pf07926, Pf09726, Pf12128, Pf12718, Pf13870, Pf15233, Pf15619",4253,ENSG00000258941.4,CTAGE5; MIA2,14,,,,0,High,1
O43719,HIV Tat-specific factor 1 OS=Homo sapiens OX=9606 GN=HTATSF1 PE=1 SV=1,0,53.482,20,11,32,11,755,85.8,4.4,14990,,11,,metabolic process;regulation of biological process,nucleus;spliceosomal complex,RNA binding,"Pf00076, Pf13893, Pf14259",27336,ENSG00000102241.11,HTATSF1,X,,,,0,High,1
Q9UH62,Armadillo repeat-containing X-linked protein 3 OS=Homo sapiens OX=9606 GN=ARMCX3 PE=1 SV=1,0,53.45,36,10,48,9,379,42.5,8.37,19665,,10,,regulation of biological process,cytoplasm;membrane;mitochondrion;nucleus,protein binding,"Pf04826, Pf09759",51566,ENSG00000102401.19,ARMCX3,X,,,,0,High,1
P11908,Ribose-phosphate pyrophosphokinase 2 OS=Homo sapiens OX=9606 GN=PRPS2 PE=1 SV=2,0,53.447,22,6,57,1,318,34.7,6.61,24893,2.64,6,2,metabolic process,,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00156, Pf13793, Pf14572",5634,ENSG00000101911.12,PRPS2,X,Pentose phosphate pathway; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; Purine metabolism,Nucleotide Metabolism,5-Phosphoribose 1-diphosphate biosynthesis,10,High,1
Q9BQ69,ADP-ribose glycohydrolase MACROD1 OS=Homo sapiens OX=9606 GN=MACROD1 PE=1 SV=2,0,53.445,22,4,102,4,325,35.5,9.51,51784,29.57,3,2,metabolic process;response to stimulus,membrane;mitochondrion;nucleus,catalytic activity;protein binding,"Pf00820, Pf01661",28992,ENSG00000133315.10,MACROD1,11,,,,0,High,1
Q7Z3B4,Nucleoporin p54 OS=Homo sapiens OX=9606 GN=NUP54 PE=1 SV=2,0,53.435,28,12,38,12,507,55.4,7.02,14249,1.86,12,1,cell organization and biogenesis;metabolic process;regulation of biological process;transport,membrane;nucleus,protein binding;structural molecule activity;transporter activity,Pf13874,53371,ENSG00000138750.14,NUP54,4,RNA transport,,Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins,64,High,1
P02462,Collagen alpha-1(IV) chain OS=Homo sapiens OX=9606 GN=COL4A1 PE=1 SV=4,0,53.353,3,4,49,4,1669,160.5,8.28,23350,0,4,1,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,extracellular;organelle lumen,protein binding;structural molecule activity,"Pf01391, Pf01413",1282,ENSG00000187498.14,COL4A1,13,Pathways in cancer; PI3K-Akt signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Focal adhesion; Amoebiasis; Small cell lung cancer; Protein digestion and absorption; ECM-receptor interaction,Spinal Cord Injury; miRNA targets in ECM and membrane receptors; Focal Adhesion; Overview of nanoparticle effects; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,,13,High,1
P62280,40S ribosomal protein S11 OS=Homo sapiens OX=9606 GN=RPS11 PE=1 SV=3,0,53.328,39,9,233,9,158,18.4,10.3,115817,12.27,8,1,cell differentiation;cell organization and biogenesis;metabolic process;transport,cytoplasm;cytosol;membrane;ribosome,protein binding;RNA binding;structural molecule activity,Pf00366,6205,ENSG00000142534.6,RPS11,19,Ribosome,Cytoplasmic Ribosomal Proteins,"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane",38,High,1
Q01814,Plasma membrane calcium-transporting ATPase 2 OS=Homo sapiens OX=9606 GN=ATP2B2 PE=1 SV=2,0,53.327,9,10,118,3,1243,136.8,5.91,50947,,10,,cell differentiation;cellular homeostasis;transport,cytoplasm;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding;transporter activity,"Pf00122, Pf00689, Pf00690, Pf00702, Pf08282, Pf12424, Pf12710, Pf13246",491,ENSG00000157087.17,ATP2B2,3,Salivary secretion; cGMP-PKG signaling pathway; Calcium signaling pathway; Pancreatic secretion; cAMP signaling pathway; Adrenergic signaling in cardiomyocytes,Calcium Regulation in the Cardiac Cell,Ion homeostasis; Reduction of cytosolic Ca++ levels; Ion transport by P-type ATPases,17,High,1
Q13107,Ubiquitin carboxyl-terminal hydrolase 4 OS=Homo sapiens OX=9606 GN=USP4 PE=1 SV=3,0,53.323,14,13,44,10,963,108.5,5.71,15909,,13,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;nucleus;vacuole,catalytic activity;metal ion binding;protein binding,"Pf00443, Pf06337, Pf13423, Pf14836",7375,ENSG00000114316.12,USP4,3,,,Regulation of TNFR1 signaling; Ub-specific processing proteases; TNFR1-induced NFkappaB signaling pathway; TNFR1-induced proapoptotic signaling,10,High,1
Q96DI7,U5 small nuclear ribonucleoprotein 40 kDa protein OS=Homo sapiens OX=9606 GN=SNRNP40 PE=1 SV=1,0,53.322,39,8,43,8,357,39.3,8.1,19184,,8,,cell organization and biogenesis;metabolic process,cytosol;nucleus;spliceosomal complex,protein binding;RNA binding,Pf00400,9410,ENSG00000060688.12,SNRNP40,1,Spliceosome,mRNA Processing,mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway,7,High,1
P84095,Rho-related GTP-binding protein RhoG OS=Homo sapiens OX=9606 GN=RHOG PE=1 SV=1,0,53.318,38,6,43,6,191,21.3,8.12,21084,,6,,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport,cytosol;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf04670, Pf08477",391,ENSG00000177105.9,RHOG,11,Shigellosis; Bacterial invasion of epithelial cells; Salmonella infection,Brain-Derived Neurotrophic Factor (BDNF) signaling pathway,G alpha (12/13) signalling events; Neutrophil degranulation; RHO GTPases activate KTN1; GPVI-mediated activation cascade; Sema4D induced cell migration and growth-cone collapse; Rho GTPase cycle,23,High,1
Q15006,ER membrane protein complex subunit 2 OS=Homo sapiens OX=9606 GN=EMC2 PE=1 SV=1,0,53.276,31,8,66,8,297,34.8,6.57,29860,,8,,metabolic process,cytoplasm;endoplasmic reticulum;mitochondrion;nucleus,protein binding,"Pf13414, Pf13432, Pf14559",9694,ENSG00000104412.7,EMC2,8,,,,0,High,1
Q96DA6,Mitochondrial import inner membrane translocase subunit TIM14 OS=Homo sapiens OX=9606 GN=DNAJC19 PE=1 SV=3,0,53.268,65,8,93,8,116,12.5,10.1,39457,,8,,metabolic process;transport,membrane;mitochondrion,protein binding,Pf00226,131118,ENSG00000205981.6,DNAJC19,3,,,Mitochondrial protein import; Metabolism of proteins,2,High,1
Q9NT62,Ubiquitin-like-conjugating enzyme ATG3 OS=Homo sapiens OX=9606 GN=ATG3 PE=1 SV=1,0,53.216,27,7,55,7,314,35.8,4.74,27354,0,7,2,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol,catalytic activity;protein binding,"Pf03986, Pf03987, Pf10381",64422,ENSG00000144848.10,ATG3,3,Autophagy,Nanoparticle triggered autophagic cell death; Senescence and Autophagy in Cancer,Macroautophagy,5,High,1
Q8NDA2,Hemicentin-2 OS=Homo sapiens OX=9606 GN=HMCN2 PE=2 SV=3,0,53.208,3,10,628,7,5059,541.6,5.87,334532,4.18,9,1,regulation of biological process;response to stimulus,extracellular,metal ion binding;protein binding,"Pf00047, Pf07474, Pf07645, Pf07679, Pf07686, Pf08205, Pf12662, Pf12947, Pf13519, Pf13895, Pf13927, Pf14670",256158,ENSG00000148357.16,HMCN2,9,,,,0,High,1
Q96MW1,Coiled-coil domain-containing protein 43 OS=Homo sapiens OX=9606 GN=CCDC43 PE=1 SV=2,0,53.119,47,7,31,7,224,25.2,4.92,14413,0,7,1,,,protein binding,,124808,ENSG00000180329.13,CCDC43,17,,,,0,High,1
Q7Z4V5,Hepatoma-derived growth factor-related protein 2 OS=Homo sapiens OX=9606 GN=HDGFL2 PE=1 SV=1,0,53.115,14,8,59,5,671,74.3,7.49,27021,0,8,1,regulation of biological process,nucleus,protein binding,"Pf00855, Pf11467",84717,ENSG00000167674.14,HDGFRP2; HDGFL2,19,,,,0,High,1
P02654,Apolipoprotein C-I OS=Homo sapiens OX=9606 GN=APOC1 PE=1 SV=1,0,53.098,39,6,109,6,83,9.3,8.47,45821,0,6,2,cell organization and biogenesis;metabolic process;regulation of biological process;transport,endoplasmic reticulum;extracellular,enzyme regulator activity,Pf04691,341,ENSG00000130208.9,APOC1,19,,Statin Pathway,VLDL clearance; VLDL assembly,7,High,1
P24928,DNA-directed RNA polymerase II subunit RPB1 OS=Homo sapiens OX=9606 GN=POLR2A PE=1 SV=2,0,52.933,10,14,66,14,1970,217,7.37,20271,,14,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding,"Pf00623, Pf04983, Pf04990, Pf04992, Pf04997, Pf04998, Pf05000",5430,,POLR2A,17,RNA polymerase; Epstein-Barr virus infection; Metabolic pathways; Huntington's disease; Pyrimidine metabolism; Purine metabolism; Herpes simplex infection,Eukaryotic Transcription Initiation; mRNA Processing,Signaling by FGFR2 IIIa TM; RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Formation of HIV-1 elongation complex containing HIV-1 Tat; MicroRNA (miRNA) biogenesis; Formation of the HIV-1 Early Elongation Complex; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; TP53 Regulates Transcription of DNA Repair Genes; Transcriptional regulation by small RNAs; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; RNA Polymerase II HIV Promoter Escape; Formation of HIV elongation complex in the absence of HIV Tat; Transcriptional regulation of pluripotent stem cells; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; Formation of TC-NER Pre-Incision Complex; Pausing and recovery of HIV elongation; RNA Polymerase II Promoter Escape; HIV elongation arrest and recovery; RNA Pol II CTD phosphorylation and interaction with CE; Viral Messenger RNA Synthesis; RNA Polymerase II Transcription Initiation; mRNA Capping; Dual incision in TC-NER; PIWI-interacting RNA (piRNA) biogenesis; Pausing and recovery of Tat-mediated HIV elongation; Formation of the Early Elongation Complex,77,High,1
Q8IXM3,"39S ribosomal protein L41, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL41 PE=1 SV=1",0,52.93,55,5,110,5,137,15.4,9.57,59284,,5,,cell death;cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,protein binding;RNA binding;structural molecule activity,Pf09809,64975,ENSG00000182154.7,MRPL41,9,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
Q9NWU5,"39S ribosomal protein L22, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL22 PE=1 SV=1",0,52.923,38,7,73,7,206,23.6,9.94,31611,1.78,7,3,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,RNA binding;structural molecule activity,Pf00237,29093,ENSG00000082515.17,MRPL22,5,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
Q13144,Translation initiation factor eIF-2B subunit epsilon OS=Homo sapiens OX=9606 GN=EIF2B5 PE=1 SV=3,0,52.918,20,10,37,10,721,80.3,5.08,15664,,10,,cell differentiation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,protein binding;RNA binding,"Pf00132, Pf02020",8893,ENSG00000145191.12,EIF2B5,3,RNA transport,Translation Factors; MicroRNAs in cardiomyocyte hypertrophy,Recycling of eIF2:GDP,8,High,1
Q8WV93,AFG1-like ATPase OS=Homo sapiens OX=9606 GN=AFG1L PE=1 SV=2,0,52.911,23,9,80,9,481,54.8,7.27,36175,,9,,cell organization and biogenesis;metabolic process,membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding,Pf03969,246269,ENSG00000135537.16,LACE1; AFG1L,6,,,,0,High,1
Q09013,Myotonin-protein kinase OS=Homo sapiens OX=9606 GN=DMPK PE=1 SV=3,0,52.887,15,7,51,7,629,69.3,5.02,14814,50.68,5,3,cell death;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;membrane;mitochondrion;nucleus,catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf03938, Pf07714, Pf08826, Pf14531",1760,ENSG00000104936.17,DMPK,19,,,Ion homeostasis,3,High,1
Q9BWH2,FUN14 domain-containing protein 2 OS=Homo sapiens OX=9606 GN=FUNDC2 PE=1 SV=2,0,52.856,45,6,285,6,189,20.7,9.73,129796,26.06,5,3,metabolic process,mitochondrion;nucleus,,Pf04930,65991,ENSG00000165775.17,FUNDC2,X,,,,0,High,1
P33897,ATP-binding cassette sub-family D member 1 OS=Homo sapiens OX=9606 GN=ABCD1 PE=1 SV=2,0,52.855,21,10,65,9,745,82.9,8.95,28888,,10,,cell organization and biogenesis;metabolic process;transport,cytoplasm;cytosol;membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding;transporter activity,"Pf00005, Pf02456, Pf06472",215,ENSG00000101986.11,ABCD1,X,Peroxisome; ABC transporters,,Defective ABCD1 causes adrenoleukodystrophy (ALD); ABC transporters in lipid homeostasis; Linoleic acid (LA) metabolism; Beta-oxidation of very long chain fatty acids; alpha-linolenic acid (ALA) metabolism,17,High,1
Q8WWM9,Cytoglobin OS=Homo sapiens OX=9606 GN=CYGB PE=1 SV=1,0,52.847,43,8,137,8,190,21.4,6.8,64597,2.9,8,1,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol,antioxidant activity;catalytic activity;metal ion binding;protein binding;transporter activity,Pf00042,114757,ENSG00000161544.9,CYGB,17,,,Intracellular oxygen transport; eNOS activation,6,High,1
Q9GZV4,Eukaryotic translation initiation factor 5A-2 OS=Homo sapiens OX=9606 GN=EIF5A2 PE=1 SV=3,0,52.809,37,6,351,1,153,16.8,5.58,173574,9.88,5,2,metabolic process;regulation of biological process;transport,cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus,protein binding;RNA binding,Pf01287,56648,ENSG00000163577.7,EIF5A2,3,,,Hypusine synthesis from eIF5A-lysine,4,High,1
Q9HD34,LYR motif-containing protein 4 OS=Homo sapiens OX=9606 GN=LYRM4 PE=1 SV=1,0,52.806,46,6,121,6,91,10.8,10.73,61117,,6,,metabolic process,mitochondrion;nucleus;organelle lumen,,"Pf05347, Pf13232",57128,ENSG00000214113.10,LYRM4,6,,,Mitochondrial iron-sulfur cluster biogenesis,2,High,1
Q9BW30,Tubulin polymerization-promoting protein family member 3 OS=Homo sapiens OX=9606 GN=TPPP3 PE=1 SV=1,0,52.787,34,7,63,7,176,19,9.13,31374,0,7,1,cell organization and biogenesis,cytoplasm;cytoskeleton,protein binding,Pf05517,51673,ENSG00000159713.10,TPPP3,16,,,,0,High,1
A4D1E9,GTP-binding protein 10 OS=Homo sapiens OX=9606 GN=GTPBP10 PE=1 SV=1,0,52.71,35,10,38,10,387,42.9,9.03,14371,,10,,metabolic process,chromosome;mitochondrion;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding,"Pf00009, Pf01018, Pf01926, Pf02421, Pf03029, Pf10662",85865,ENSG00000105793.15,GTPBP10,7,,,,0,High,1
P19174,"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 OS=Homo sapiens OX=9606 GN=PLCG1 PE=1 SV=1",0,52.689,15,14,36,14,1290,148.4,6.05,14322,,14,,cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;metal ion binding;protein binding;signal transducer activity,"Pf00017, Pf00018, Pf00168, Pf00169, Pf00387, Pf00388, Pf03009, Pf07653, Pf09279, Pf14604",5335,ENSG00000124181.14,PLCG1,20,Non-small cell lung cancer; Vibrio cholerae infection; Phospholipase D signaling pathway; Proteoglycans in cancer; Th1 and Th2 cell differentiation; NF-kappa B signaling pathway; ErbB signaling pathway; Fc gamma R-mediated phagocytosis; VEGF signaling pathway; Fc epsilon RI signaling pathway; HIF-1 signaling pathway; Inositol phosphate metabolism; Glioma; Axon guidance; Epstein-Barr virus infection; Choline metabolism in cancer; Pathways in cancer; Metabolic pathways; MicroRNAs in cancer; EGFR tyrosine kinase inhibitor resistance; Natural killer cell mediated cytotoxicity; Ras signaling pathway; T cell receptor signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Rap1 signaling pathway; Inflammatory mediator regulation of TRP channels; Phosphatidylinositol signaling system; Calcium signaling pathway; Neurotrophin signaling pathway; Leukocyte transendothelial migration; Thyroid hormone signaling pathway; Epithelial cell signaling in Helicobacter pylori infection,Angiogenesis; IL-1 signaling pathway; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; Leptin signaling pathway; Signaling Pathways in Glioblastoma; B Cell Receptor Signaling Pathway; Corticotropin-releasing hormone signaling pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; PDGF Pathway; Primary Focal Segmental Glomerulosclerosis FSGS; T-Cell Receptor and Co-stimulatory Signaling; Myometrial Relaxation and Contraction Pathways; Kit receptor signaling pathway; MFAP5-mediated ovarian cancer cell motility and invasiveness; BDNF-TrkB Signaling; Association Between Physico-Chemical Features and Toxicity Associated Pathways; T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 Signaling Pathway; GPR40 PATHWAY; EGF/EGFR Signaling Pathway; ErbB Signaling Pathway; T-Cell antigen Receptor (TCR)  Signaling Pathway,EGFR interacts with phospholipase C-gamma; FCERI mediated Ca+2 mobilization; Signaling by FGFR4 in disease; PECAM1 interactions; ISG15 antiviral mechanism; DAG and IP3 signaling; Signaling by FGFR2 in disease; FCERI mediated MAPK activation; Downstream signal transduction; Signaling by FGFR1 in disease; Signaling by FGFR3 point mutants in cancer; DAP12 signaling; Frs2-mediated activation; Synthesis of IP3 and IP4 in the cytosol; Generation of second messenger molecules; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of phospholipids in phagocytosis; Phospholipase C-mediated cascade: FGFR1; Constitutive Signaling by EGFRvIII; Phospholipase C-mediated cascade; FGFR2; PLC-gamma1 signalling; PLCG1 events in ERBB2 signaling; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Phospholipase C-mediated cascade; FGFR4; Phospholipase C-mediated cascade; FGFR3; Role of second messengers in netrin-1 signaling; RET signaling; VEGFR2 mediated cell proliferation,128,High,1
Q01130,Serine/arginine-rich splicing factor 2 OS=Homo sapiens OX=9606 GN=SRSF2 PE=1 SV=4,0,52.64,22,5,95,5,221,25.5,11.85,48818,2.06,5,1,metabolic process;regulation of biological process;response to stimulus;transport,cytosol;nucleus;spliceosomal complex,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",6427,ENSG00000161547.16,SRSF2,17,Herpes simplex infection; Spliceosome,mRNA Processing,Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway,15,High,1
O14745,Na(+)/H(+) exchange regulatory cofactor NHE-RF1 OS=Homo sapiens OX=9606 GN=SLC9A3R1 PE=1 SV=4,0,52.631,40,10,50,10,358,38.8,5.77,21337,,10,,cell differentiation;cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;membrane;nucleus,protein binding;structural molecule activity,"Pf00595, Pf09007, Pf13180",9368,ENSG00000109062.11,SLC9A3R1,17,,,,0,High,1
O60832,H/ACA ribonucleoprotein complex subunit DKC1 OS=Homo sapiens OX=9606 GN=DKC1 PE=1 SV=3,0,52.59,25,10,61,10,514,57.6,9.42,24110,,10,,cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process,cytoplasm;nucleus,catalytic activity;protein binding;RNA binding,"Pf01472, Pf01509, Pf08068",1736,ENSG00000130826.17,DKC1,X,Ribosome biogenesis in eukaryotes,,rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase,10,High,1
P61960,Ubiquitin-fold modifier 1 OS=Homo sapiens OX=9606 GN=UFM1 PE=1 SV=1,0,52.589,68,5,122,5,85,9.1,9.31,50720,0,5,1,metabolic process;regulation of biological process;response to stimulus,cytoplasm;endoplasmic reticulum;nucleus,protein binding,Pf03671,51569,ENSG00000120686.11,UFM1,13,,,,0,High,1
Q8NEU8,DCC-interacting protein 13-beta OS=Homo sapiens OX=9606 GN=APPL2 PE=1 SV=3,0,52.556,20,11,70,10,664,74.4,4.94,32556,,11,,cell proliferation;regulation of biological process;response to stimulus,cytoplasm;endosome;membrane;nucleus,protein binding,"Pf00169, Pf00640",55198,ENSG00000136044.11,APPL2,12,,,,0,High,1
A0A0C4DH72,Immunoglobulin kappa variable 1-6 OS=Homo sapiens OX=9606 GN=IGKV1-6 PE=3 SV=1,0,52.548,37,8,49,1,117,12.7,8.29,24308,,8,,response to stimulus,extracellular;membrane,,"Pf00047, Pf07679, Pf07686, Pf13927",28943,ENSG00000282163.1; ENSG00000239855.1,IGKV1-6,2; CHR_HG2290_PATCH,,,,0,High,1
Q9BRQ6,MICOS complex subunit MIC25 OS=Homo sapiens OX=9606 GN=CHCHD6 PE=1 SV=1,0,52.521,30,5,56,5,235,26.4,8.85,28483,,5,,cell organization and biogenesis;response to stimulus,cytosol;membrane;mitochondrion,protein binding,Pf05300,84303,ENSG00000159685.10,CHCHD6,3,,,Cristae formation,3,High,1
O15530,3-phosphoinositide-dependent protein kinase 1 OS=Homo sapiens OX=9606 GN=PDPK1 PE=1 SV=1,0,52.498,29,9,43,9,556,63.1,7.36,15555,,9,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding,"Pf00069, Pf07714, Pf14531, Pf14593",5170,ENSG00000140992.18,PDPK1,16,Insulin signaling pathway; Sphingolipid signaling pathway; Choline metabolism in cancer; Thyroid hormone signaling pathway; Neurotrophin signaling pathway; Insulin resistance; mTOR signaling pathway; Focal adhesion; Endometrial cancer; Platinum drug resistance; FoxO signaling pathway; Fc epsilon RI signaling pathway; Toxoplasmosis; T cell receptor signaling pathway; Aldosterone-regulated sodium reabsorption; Prostate cancer; AMPK signaling pathway; Non-small cell lung cancer; PI3K-Akt signaling pathway; Proteoglycans in cancer; PPAR signaling pathway; Hepatitis C; Apoptosis,MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated Cell Adhesion; Human Thyroid Stimulating Hormone (TSH) signaling pathway; Signaling Pathways in Glioblastoma; B Cell Receptor Signaling Pathway; Interleukin-11 Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Cardiac Hypertrophic Response; Focal Adhesion; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Leptin Insulin Overlap; PPAR signaling pathway; EGF/EGFR Signaling Pathway; Insulin Signaling; T-Cell antigen Receptor (TCR)  Signaling Pathway,Downstream TCR signaling; Activation of AKT2; CTLA4 inhibitory signaling; G beta:gamma signalling through PI3Kgamma; Regulation of TP53 Degradation; Integrin alphaIIb beta3 signaling; FCERI mediated NF-kB activation; Constitutive Signaling by AKT1 E17K in Cancer; PIP3 activates AKT signaling; GPVI-mediated activation cascade; CD28 dependent PI3K/Akt signaling; VEGFR2 mediated vascular permeability; VEGFR2 mediated cell proliferation; Role of LAT2/NTAL/LAB on calcium mobilization; CLEC7A (Dectin-1) signaling; RSK activation; RHO GTPases activate PKNs,101,High,1
P07947,Tyrosine-protein kinase Yes OS=Homo sapiens OX=9606 GN=YES1 PE=1 SV=3,0,52.497,20,12,79,5,543,60.8,6.74,36575,,12,,cell differentiation;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;Golgi;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00017, Pf00018, Pf00069, Pf07653, Pf07714, Pf14604",7525,ENSG00000176105.13,YES1,18,Tight junction; Adherens junction,Interleukin-11 Signaling Pathway,PECAM1 interactions; CTLA4 inhibitory signaling; EPH-ephrin mediated repulsion of cells; EPHA-mediated growth cone collapse; RUNX2 regulates osteoblast differentiation; EPHB-mediated forward signaling; Regulation of signaling by CBL; CD28 co-stimulation; Regulation of KIT signaling; FCGR activation; Signaling by ERBB2,35,High,1
Q14498,RNA-binding protein 39 OS=Homo sapiens OX=9606 GN=RBM39 PE=1 SV=2,0,52.48,24,9,32,9,530,59.3,10.1,15199,,9,,metabolic process;regulation of biological process,cytoskeleton;nucleus,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259, Pf15519",9584,ENSG00000131051.22,RBM39,20,,mRNA Processing,,1,High,1
Q9NR56-5,Isoform 5 of Muscleblind-like protein 1 OS=Homo sapiens OX=9606 GN=MBNL1,0,52.457,14,5,78,5,382,41,8.75,28150,46.69,4,1,cell differentiation;metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,metal ion binding;protein binding;RNA binding,,4154,ENSG00000152601.17,MBNL1,3,,Adipogenesis,,1,High,1
P14649,Myosin light chain 6B OS=Homo sapiens OX=9606 GN=MYL6B PE=1 SV=1,0,52.423,49,10,126,8,208,22.8,5.73,63130,0,10,1,cellular component movement,cytosol,catalytic activity;metal ion binding;motor activity;protein binding;structural molecule activity,"Pf13405, Pf13499",140465,ENSG00000196465.10,MYL6B,12,Oxytocin signaling pathway; Vascular smooth muscle contraction,,Smooth Muscle Contraction,4,High,1
Q9Y534,Cold shock domain-containing protein C2 OS=Homo sapiens OX=9606 GN=CSDC2 PE=1 SV=1,0,52.423,67,6,98,6,153,16.8,7.55,47514,0,6,1,metabolic process;regulation of biological process,cytoplasm;nucleus,DNA binding;protein binding;RNA binding,Pf00313,27254,ENSG00000172346.14,CSDC2,22,,,,0,High,1
O43324,Eukaryotic translation elongation factor 1 epsilon-1 OS=Homo sapiens OX=9606 GN=EEF1E1 PE=1 SV=1,0,52.406,48,7,56,7,174,19.8,8.54,27699,,7,,metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,"Pf00043, Pf13410, Pf14497",9521,ENSG00000124802.11,EEF1E1,6,,,Cytosolic tRNA aminoacylation; SeMet incorporation into proteins,8,High,1
P61006,Ras-related protein Rab-8A OS=Homo sapiens OX=9606 GN=RAB8A PE=1 SV=1,0,52.398,40,8,140,2,207,23.7,9.07,77260,0,7,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endosome;Golgi;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf08477",4218,ENSG00000167461.11,RAB8A,19,Pancreatic secretion; Endocytosis; AMPK signaling pathway,Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,Translocation of GLUT4 to the plasma membrane; TBC/RABGAPs; VxPx cargo-targeting to cilium; Regulation of PLK1 Activity at G2/M Transition; Anchoring of the basal body to the plasma membrane; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation,23,High,1
P51151,Ras-related protein Rab-9A OS=Homo sapiens OX=9606 GN=RAB9A PE=1 SV=1,0,52.289,55,7,74,6,201,22.8,5.47,30494,,7,,regulation of biological process;response to stimulus;transport,cytosol;endoplasmic reticulum;endosome;Golgi;membrane;vacuole,catalytic activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf01926, Pf04670, Pf08477",9367,ENSG00000123595.7,RAB9A,X,Measles,,Retrograde transport at the Trans-Golgi-Network; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation,10,High,1
O75592,E3 ubiquitin-protein ligase MYCBP2 OS=Homo sapiens OX=9606 GN=MYCBP2 PE=1 SV=4,0,52.284,4,14,33,14,4678,513.3,7.02,11255,,14,,,,,,,,,,,,,0,High,1
P09455,Retinol-binding protein 1 OS=Homo sapiens OX=9606 GN=RBP1 PE=1 SV=2,0,52.266,60,9,53,9,135,15.8,5.11,22987,0,9,1,metabolic process;transport,cytoplasm;cytosol,transporter activity,Pf00061,5947,ENSG00000114115.9,RBP1,3,,Retinoblastoma (RB) in Cancer; Vitamin A and Carotenoid Metabolism,Signaling by GPCR; Retinoid cycle disease events; The canonical retinoid cycle in rods (twilight vision); Retinoid metabolism and transport,14,High,1
Q9H6K4,Optic atrophy 3 protein OS=Homo sapiens OX=9606 GN=OPA3 PE=1 SV=1,0,52.254,30,5,113,5,179,20,8.91,51162,19.14,4,2,cell organization and biogenesis;regulation of biological process;response to stimulus,mitochondrion,,Pf07047,80207,ENSG00000125741.4,OPA3,19,,,,0,High,1
P62829,60S ribosomal protein L23 OS=Homo sapiens OX=9606 GN=RPL23 PE=1 SV=1,0,52.238,31,6,160,6,140,14.9,10.51,71711,0,6,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;ribosome,protein binding;RNA binding;structural molecule activity,Pf00238,9349,ENSG00000125691.12,RPL23,17,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
Q9BTY7,Protein HGH1 homolog OS=Homo sapiens OX=9606 GN=HGH1 PE=1 SV=1,0,52.209,25,7,39,7,390,42.1,4.81,15764,,7,,,,,"Pf04063, Pf04064",51236,ENSG00000235173.6,FAM203B; FAM203A; HGH1,8,,,,0,High,1
P02746,Complement C1q subcomponent subunit B OS=Homo sapiens OX=9606 GN=C1QB PE=1 SV=3,0,52.181,24,6,78,6,253,26.7,8.63,35629,9.73,5,1,defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,catalytic activity;protein binding,"Pf00229, Pf00386",713,ENSG00000173369.15,C1QB,1,Prion diseases; Complement and coagulation cascades; Chagas disease (American trypanosomiasis); Staphylococcus aureus infection; Pertussis; Systemic lupus erythematosus,Allograft Rejection; Spinal Cord Injury; Microglia Pathogen Phagocytosis Pathway; Oxidative Damage; Complement Activation; Complement and Coagulation Cascades,Regulation of Complement cascade; Classical antibody-mediated complement activation,19,High,1
P83436,Conserved oligomeric Golgi complex subunit 7 OS=Homo sapiens OX=9606 GN=COG7 PE=1 SV=1,0,52.172,21,12,45,12,770,86.3,5.47,16180,,12,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,Golgi;membrane,protein binding,Pf10191,91949,ENSG00000168434.12,COG7,16,,,COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network,11,High,1
Q5SRE5,Nucleoporin NUP188 homolog OS=Homo sapiens OX=9606 GN=NUP188 PE=1 SV=1,0,52.154,9,12,35,12,1749,195.9,6.73,13343,,12,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport,membrane;nucleus,structural molecule activity,"Pf10487, Pf11894",23511,ENSG00000095319.14,NUP188,9,RNA transport,,Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins,64,High,1
P16278,Beta-galactosidase OS=Homo sapiens OX=9606 GN=GLB1 PE=1 SV=2,0,52.078,21,11,38,11,677,76,6.57,16080,,11,,metabolic process;response to stimulus;transport,cytoplasm;extracellular;Golgi;organelle lumen;vacuole,catalytic activity;protein binding,"Pf01301, Pf02449, Pf13364",2720,,GLB1,3,Glycosphingolipid biosynthesis - ganglio series; Other glycan degradation; Glycosaminoglycan degradation; Metabolic pathways; Sphingolipid metabolism; Galactose metabolism; Lysosome,Ectoderm Differentiation,Sialic acid metabolism; Neutrophil degranulation; MPS IV - Morquio syndrome B; Glycosphingolipid metabolism; HS-GAG degradation; Keratan sulfate degradation,32,High,1
Q5ST30,"Valine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=VARS2 PE=1 SV=2",0,52.032,17,13,33,13,1063,118.4,7.02,11868,,13,,metabolic process;regulation of biological process,cytosol;mitochondrion,catalytic activity;nucleotide binding;protein binding,"Pf00133, Pf08264, Pf09334",57176,ENSG00000223494.9; ENSG00000137411.16,VARS2,6; CHR_HSCHR6_MHC_MANN_CTG1,Aminoacyl-tRNA biosynthesis,,Mitochondrial tRNA aminoacylation,5,High,1
O75223,Gamma-glutamylcyclotransferase OS=Homo sapiens OX=9606 GN=GGCT PE=1 SV=1,0,51.945,52,8,44,8,188,21,5.14,21683,0,8,1,cell organization and biogenesis;metabolic process,cytosol,catalytic activity;protein binding,"Pf06094, Pf13772",79017,ENSG00000006625.17,GGCT,7,Glutathione metabolism,,Glutathione synthesis and recycling,6,High,1
O43592,Exportin-T OS=Homo sapiens OX=9606 GN=XPOT PE=1 SV=2,0,51.928,16,11,34,11,962,109.9,5.39,15115,,11,,transport,cytoplasm;cytosol;nucleus,protein binding;RNA binding,Pf08389,11260,ENSG00000184575.11,XPOT,12,RNA transport,,tRNA processing in the nucleus,4,High,1
Q9H3Q1,Cdc42 effector protein 4 OS=Homo sapiens OX=9606 GN=CDC42EP4 PE=1 SV=1,0,51.913,38,7,36,7,356,38,5.19,14689,,7,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;membrane,enzyme regulator activity;protein binding;RNA binding,"Pf00786, Pf14957",23580,ENSG00000179604.9,CDC42EP4,17,,,,0,High,1
Q13445,Transmembrane emp24 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=TMED1 PE=1 SV=1,0,51.901,34,7,62,7,227,25.2,4.48,26254,,7,,cell communication;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;Golgi;membrane,protein binding,Pf01105,11018,ENSG00000099203.6,TMED1,19,,,,0,High,1
Q96JC1,Vam6/Vps39-like protein OS=Homo sapiens OX=9606 GN=VPS39 PE=1 SV=2,0,51.844,16,11,48,11,886,101.7,6.99,20623,,11,,cell organization and biogenesis;metabolic process;transport,cytoplasm;endosome;membrane;vacuole,protein binding,"Pf00780, Pf10366, Pf10367",23339,ENSG00000166887.15,VPS39,15,,,,0,High,1
Q96A35,"39S ribosomal protein L24, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL24 PE=1 SV=1",0,51.842,47,11,76,11,216,24.9,9.29,31087,,11,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,structural molecule activity,Pf00467,79590,ENSG00000143314.12,MRPL24,1,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
Q5JSH3,WD repeat-containing protein 44 OS=Homo sapiens OX=9606 GN=WDR44 PE=1 SV=1,0,51.818,17,11,42,11,913,101.3,5.45,17532,0,11,1,,cytoplasm;cytosol;endosome;Golgi;membrane,protein binding,Pf00400,54521,ENSG00000131725.13,WDR44,X,,Ectoderm Differentiation,,1,High,1
Q08554,Desmocollin-1 OS=Homo sapiens OX=9606 GN=DSC1 PE=1 SV=2,0,51.781,10,6,48,6,894,99.9,5.43,23300,,6,,cell death;transport,cytoskeleton;membrane,metal ion binding,"Pf00028, Pf01049, Pf08758",1823,ENSG00000134765.9,DSC1,18,,,Formation of the cornified envelope; Neutrophil degranulation,6,High,1
Q9Y2V7,Conserved oligomeric Golgi complex subunit 6 OS=Homo sapiens OX=9606 GN=COG6 PE=1 SV=2,0,51.748,25,10,41,10,657,73.2,5.76,17303,,10,,metabolic process;transport,Golgi;membrane,protein binding,Pf06419,57511,ENSG00000133103.16,COG6,13,,,COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network,11,High,1
P55145,Mesencephalic astrocyte-derived neurotrophic factor OS=Homo sapiens OX=9606 GN=MANF PE=1 SV=3,0,51.739,29,7,132,7,182,20.7,8.69,45495,,7,,cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytosol;endoplasmic reticulum;extracellular;nucleus,protein binding;RNA binding,Pf10208,7873,,MANF,3,,,Platelet degranulation,4,High,1
Q9NP92,"39S ribosomal protein S30, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS30 PE=1 SV=2",0,51.684,25,7,42,7,439,50.3,7.97,18280,,7,,cell death;cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,RNA binding;structural molecule activity,Pf07147,10884,ENSG00000112996.10,MRPS30,5,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
Q2PZI1,Probable C-mannosyltransferase DPY19L1 OS=Homo sapiens OX=9606 GN=DPY19L1 PE=2 SV=1,0,51.681,14,7,60,7,675,77.3,8.95,21339,,7,,metabolic process,membrane,catalytic activity,Pf10034,23333,ENSG00000173852.14,DPY19L1,7,,,,0,High,1
O00264,Membrane-associated progesterone receptor component 1 OS=Homo sapiens OX=9606 GN=PGRMC1 PE=1 SV=3,0,51.645,57,9,58,9,195,21.7,4.7,26752,,9,,transport,endoplasmic reticulum;membrane,protein binding,Pf00173,10857,ENSG00000101856.9,PGRMC1,X,,,Neutrophil degranulation,3,High,1
Q96A49,Synapse-associated protein 1 OS=Homo sapiens OX=9606 GN=SYAP1 PE=1 SV=1,0,51.641,31,7,36,7,352,39.9,4.53,17492,,7,,,cytosol;Golgi;nucleus,protein binding,Pf03909,94056,ENSG00000169895.5,SYAP1,X,,,,0,High,1
Q9BXF6,Rab11 family-interacting protein 5 OS=Homo sapiens OX=9606 GN=RAB11FIP5 PE=1 SV=1,0,51.623,17,8,39,8,653,70.4,9.23,18833,,8,,regulation of biological process;response to stimulus;transport,cytoplasm;endosome;Golgi;membrane;mitochondrion,protein binding,"Pf00168, Pf09457",26056,ENSG00000135631.16,RAB11FIP5,2,Endocytosis,,,1,High,1
Q8TCE6,DENN domain-containing protein 10 OS=Homo sapiens OX=9606 GN=DENND10 PE=1 SV=1,0,51.589,32,9,36,9,357,40.5,6.61,16558,,9,,,,,"Pf08616, Pf09794",404636,ENSG00000119979.16,FAM45A,10,,,,0,High,1
Q12891,Hyaluronidase-2 OS=Homo sapiens OX=9606 GN=HYAL2 PE=1 SV=4,0,51.541,22,7,38,7,473,53.8,8.19,15218,,7,,cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;cytosol;endoplasmic reticulum;membrane;vacuole,catalytic activity;enzyme regulator activity;protein binding;receptor activity,Pf01630,8692,ENSG00000068001.13,HYAL2,3,Glycosaminoglycan degradation; Metabolic pathways,,Hyaluronan uptake and degradation,7,High,1
P05161,Ubiquitin-like protein ISG15 OS=Homo sapiens OX=9606 GN=ISG15 PE=1 SV=5,0,51.541,35,7,52,7,165,17.9,7.44,23669,,7,,defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;extracellular,protein binding,Pf00240,9636,ENSG00000187608.8,ISG15,1,RIG-I-like receptor signaling pathway,RIG-I-like Receptor Signaling; Type II interferon signaling (IFNG),Interferon alpha/beta signaling; Termination of translesion DNA synthesis; ISG15 antiviral mechanism;  NS1 Mediated Effects on Host Pathways; Negative regulators of DDX58/IFIH1 signaling,21,High,1
Q12769,Nuclear pore complex protein Nup160 OS=Homo sapiens OX=9606 GN=NUP160 PE=1 SV=3,0,51.535,8,10,54,10,1436,162,5.5,20577,,10,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,chromosome;cytosol;nucleus,protein binding;transporter activity,Pf11715,23279,ENSG00000030066.13,NUP160,11,RNA transport,,Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; Separation of Sister Chromatids; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Resolution of Sister Chromatid Cohesion; Transport of Ribonucleoproteins into the Host Nucleus; RHO GTPases Activate Formins; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins,77,High,1
Q8WUK0,Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 OS=Homo sapiens OX=9606 GN=PTPMT1 PE=1 SV=1,0,51.508,37,6,64,6,201,22.8,9.77,29526,,6,,metabolic process,membrane;mitochondrion;nucleus,catalytic activity;protein binding,"Pf00102, Pf00782, Pf14671",114971,ENSG00000110536.13,PTPMT1,11,,,Synthesis of PG,5,High,1
P31483-2,Isoform Short of Nucleolysin TIA-1 isoform p40 OS=Homo sapiens OX=9606 GN=TIA1,0,51.502,29,7,48,5,375,41.8,7.74,23738,,7,,cell death;regulation of biological process;response to stimulus,cytoplasm;cytosol,protein binding;RNA binding,"Pf00076, Pf04847, Pf13893, Pf14259",7072,ENSG00000116001.15,TIA1,2,,,,0,High,1
Q9UP83,Conserved oligomeric Golgi complex subunit 5 OS=Homo sapiens OX=9606 GN=COG5 PE=1 SV=3,0,51.498,18,10,35,10,839,92.7,6.6,15841,,10,,transport,cytoplasm;cytosol;Golgi;membrane,protein binding;transporter activity,"Pf05992, Pf08700, Pf10392",10466,ENSG00000164597.13,COG5,7,,,COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network,11,High,1
Q15904,V-type proton ATPase subunit S1 OS=Homo sapiens OX=9606 GN=ATP6AP1 PE=1 SV=2,0,51.486,20,9,51,9,470,52,6.14,20557,,9,,cellular homeostasis;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;membrane,catalytic activity;nucleotide binding;protein binding;transporter activity,Pf05827,537,ENSG00000071553.16,ATP6AP1,X,Oxidative phosphorylation; Lysosome; Epithelial cell signaling in Helicobacter pylori infection; Tuberculosis; Vibrio cholerae infection; Phagosome; Hepatitis B; Rheumatoid arthritis; Metabolic pathways,Oxidative phosphorylation,Transferrin endocytosis and recycling; Ion channel transport; Insulin receptor recycling,18,High,1
O43766,"Lipoyl synthase, mitochondrial OS=Homo sapiens OX=9606 GN=LIAS PE=1 SV=3",0,51.475,37,9,39,9,372,41.9,8.59,14971,23.64,7,3,defense response;metabolic process;response to stimulus,mitochondrion;organelle lumen,catalytic activity;metal ion binding,Pf04055,11019,ENSG00000121897.14,LIAS,4,Metabolic pathways; Lipoic acid metabolism,,Glyoxylate metabolism and glycine degradation,5,High,1
Q9NXE4,Sphingomyelin phosphodiesterase 4 OS=Homo sapiens OX=9606 GN=SMPD4 PE=1 SV=3,0,51.421,13,9,63,9,866,97.7,8.27,28337,,9,,,,,,,,,,,,,0,High,1
O14832,"Phytanoyl-CoA dioxygenase, peroxisomal OS=Homo sapiens OX=9606 GN=PHYH PE=1 SV=1",0,51.402,32,8,56,8,338,38.5,8.47,25570,,8,,metabolic process,mitochondrion;organelle lumen,catalytic activity;metal ion binding;protein binding,Pf05721,5264,ENSG00000107537.13,PHYH,10,Peroxisome,,Alpha-oxidation of phytanate,6,High,1
Q969Q1,E3 ubiquitin-protein ligase TRIM63 OS=Homo sapiens OX=9606 GN=TRIM63 PE=1 SV=1,0,51.364,23,8,79,6,353,40.2,4.92,29762,29.34,4,5,metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,catalytic activity;metal ion binding;protein binding;signal transducer activity,"Pf00097, Pf00643, Pf13445, Pf13639, Pf13923, Pf14835, Pf15227",84676,ENSG00000158022.6,TRIM63,1,,TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling,Antigen processing: Ubiquitination & Proteasome degradation,6,High,1
Q5JR59,Microtubule-associated tumor suppressor candidate 2 OS=Homo sapiens OX=9606 GN=MTUS2 PE=1 SV=3,0,51.344,9,9,26,9,1369,150.1,6.68,8651,10.21,7,4,,cytoplasm;cytoskeleton;nucleus,protein binding,,23281,,MTUS2,13,,,,0,High,1
P56211,cAMP-regulated phosphoprotein 19 OS=Homo sapiens OX=9606 GN=ARPP19 PE=1 SV=2,0,51.33,63,7,61,6,112,12.3,9.09,27519,,7,,cell division;regulation of biological process,cytoplasm,enzyme regulator activity;protein binding,Pf04667,10776,ENSG00000128989.10,ARPP19,15,,,MASTL Facilitates Mitotic Progression,5,High,1
Q01469,Fatty acid-binding protein 5 OS=Homo sapiens OX=9606 GN=FABP5 PE=1 SV=3,0,51.32,43,7,184,7,135,15.2,7.01,92163,14.16,5,2,metabolic process;transport,cytoplasm;cytosol;extracellular;membrane;organelle lumen,protein binding;transporter activity,Pf00061,2171,ENSG00000164687.10,FABP5,8,PPAR signaling pathway,PPAR signaling pathway,Triglyceride catabolism; Signaling by Retinoic Acid; Neutrophil degranulation,12,High,1
P98095,Fibulin-2 OS=Homo sapiens OX=9606 GN=FBLN2 PE=1 SV=2,0,51.316,5,5,58,5,1184,126.5,4.82,26772,,5,,cell organization and biogenesis;regulation of biological process,extracellular,metal ion binding;structural molecule activity,"Pf01821, Pf07645, Pf12662, Pf14670",2199,ENSG00000163520.13,FBLN2,3,,,Molecules associated with elastic fibres,3,High,1
Q96AP7,Endothelial cell-selective adhesion molecule OS=Homo sapiens OX=9606 GN=ESAM PE=1 SV=1,0,51.303,24,6,40,6,390,41.2,9.32,17296,,6,,cellular component movement,membrane,protein binding,"Pf00047, Pf07679, Pf13895, Pf13927",90952,ENSG00000149564.11,ESAM,11,Leukocyte transendothelial migration; Cell adhesion molecules (CAMs),,Cell surface interactions at the vascular wall,4,High,1
Q9Y520,Protein PRRC2C OS=Homo sapiens OX=9606 GN=PRRC2C PE=1 SV=4,0,51.242,7,13,77,13,2896,316.7,9.13,30895,,13,,cell differentiation,membrane,protein binding;RNA binding,Pf07001,23215,,PRRC2C,1,,,,0,High,1
Q16537,Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform OS=Homo sapiens OX=9606 GN=PPP2R5E PE=1 SV=1,0,51.229,19,9,59,7,467,54.7,6.95,25787,,9,,regulation of biological process;response to stimulus,cytoplasm;cytosol,enzyme regulator activity;protein binding,Pf01603,5529,ENSG00000154001.13,PPP2R5E,14,Sphingolipid signaling pathway; Adrenergic signaling in cardiomyocytes; mRNA surveillance pathway; PI3K-Akt signaling pathway; Oocyte meiosis; AMPK signaling pathway; Dopaminergic synapse,Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Wnt Signaling Pathway and Pluripotency; Wnt Signaling Pathway; Glycogen Metabolism; DNA Damage Response (only ATM dependent),"Beta-catenin phosphorylation cascade; AXIN missense mutants destabilize the destruction complex; Negative regulation of MAPK pathway; APC truncation mutants have impaired AXIN binding; CTLA4 inhibitory signaling; Platelet sensitization by LDL; Separation of Sister Chromatids; Interleukin-20 family signaling; S37 mutants of beta-catenin aren't phosphorylated; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; S33 mutants of beta-catenin aren't phosphorylated; Disassembly of the destruction complex and recruitment of AXIN to the membrane; S45 mutants of beta-catenin aren't phosphorylated; Misspliced GSK3beta mutants stabilize beta-catenin; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Resolution of Sister Chromatid Cohesion; T41 mutants of beta-catenin aren't phosphorylated; RHO GTPases Activate Formins; RAF activation; Truncations of AMER1 destabilize the destruction complex",67,High,1
O76021,Ribosomal L1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RSL1D1 PE=1 SV=3,0,51.211,26,10,52,10,490,54.9,10.13,20422,,10,,cell differentiation;metabolic process;regulation of biological process,membrane;nucleus,protein binding;RNA binding,"Pf06030, Pf11797",26156,ENSG00000171490.12,RSL1D1,16,,Senescence and Autophagy in Cancer,,1,High,1
P42226,Signal transducer and activator of transcription 6 OS=Homo sapiens OX=9606 GN=STAT6 PE=1 SV=1,0,51.21,16,10,39,10,847,94.1,6.23,14241,,10,,cell proliferation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,DNA binding;protein binding;signal transducer activity,"Pf00017, Pf01017, Pf02864, Pf02865, Pf14596",6778,ENSG00000166888.11,STAT6,12,Inflammatory bowel disease (IBD); Jak-STAT signaling pathway; Hepatitis B; Th1 and Th2 cell differentiation,Adipogenesis; VEGFA-VEGFR2 Signaling Pathway; IL-4 Signaling Pathway,STAT6-mediated induction of chemokines; Interleukin-4 and 13 signaling; Downstream signal transduction,19,High,1
P41236,Protein phosphatase inhibitor 2 OS=Homo sapiens OX=9606 GN=PPP1R2 PE=1 SV=2,0,51.145,35,6,59,6,205,23,4.74,22525,0,6,1,metabolic process;regulation of biological process,cytosol,enzyme regulator activity;protein binding,Pf04979,5504,ENSG00000184203.7,PPP1R2,3,,,,0,High,1
Q96EK7,Constitutive coactivator of peroxisome proliferator-activated receptor gamma OS=Homo sapiens OX=9606 GN=FAM120B PE=1 SV=1,0,51.125,21,14,29,14,910,103.7,5.69,9986,5.12,13,1,cell differentiation;metabolic process;regulation of biological process;response to stimulus,nucleus,protein binding,"Pf12813, Pf15548",84498,ENSG00000275333.4; ENSG00000112584.13,FAM120B,6; CHR_HSCHR6_1_CTG5,,,Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression,6,High,1
Q96E11,"Ribosome-recycling factor, mitochondrial OS=Homo sapiens OX=9606 GN=MRRF PE=1 SV=1",0,51.11,26,6,97,6,262,29.3,9.79,46833,,6,,cell organization and biogenesis;metabolic process,mitochondrion;organelle lumen,,Pf01765,92399,ENSG00000148187.17,MRRF,9,,,Mitochondrial translation termination,4,High,1
Q9NQ50,"39S ribosomal protein L40, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL40 PE=1 SV=1",0,51.103,42,6,54,6,206,24.5,9.63,24137,,6,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;nucleus;ribosome,protein binding;RNA binding,Pf09812,64976,ENSG00000185608.8,MRPL40,22,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
Q9UBG0,C-type mannose receptor 2 OS=Homo sapiens OX=9606 GN=MRC2 PE=1 SV=2,0,51.094,8,8,53,8,1479,166.6,5.83,22396,,8,,cell differentiation;metabolic process;regulation of biological process;response to stimulus;transport,membrane,protein binding;receptor activity;signal transducer activity,"Pf00040, Pf00059",9902,ENSG00000011028.13,MRC2,17,Tuberculosis; Phagosome,,Cross-presentation of soluble exogenous antigens (endosomes),7,High,1
Q9ULU8,Calcium-dependent secretion activator 1 OS=Homo sapiens OX=9606 GN=CADPS PE=1 SV=3,0,51.089,10,11,50,11,1353,152.7,5.71,19695,,11,,cell organization and biogenesis;transport,cytosol;membrane,metal ion binding;protein binding,"Pf00169, Pf06292",8618,ENSG00000163618.17,CADPS,3,,,,0,High,1
Q9NXG2,THUMP domain-containing protein 1 OS=Homo sapiens OX=9606 GN=THUMPD1 PE=1 SV=2,0,51.026,21,7,39,7,353,39.3,7.88,18238,,7,,metabolic process,,protein binding;RNA binding,Pf02926,55623,ENSG00000066654.13,THUMPD1,16,,,rRNA modification in the nucleus and cytosol,4,High,1
Q96JJ3,Engulfment and cell motility protein 2 OS=Homo sapiens OX=9606 GN=ELMO2 PE=1 SV=2,0,51.008,22,11,61,9,720,82.6,5.9,23200,,11,,cell death;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane,protein binding,"Pf04727, Pf11841",63916,ENSG00000062598.17,ELMO2,20,Bacterial invasion of epithelial cells; Shigellosis,,"PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; Regulation of actin dynamics for phagocytic cup formation; VEGFA-VEGFR2 Pathway",13,High,1
Q9BQA1,Methylosome protein 50 OS=Homo sapiens OX=9606 GN=WDR77 PE=1 SV=1,0,50.983,33,6,51,5,342,36.7,5.17,23391,19.37,6,1,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;Golgi;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding,Pf00400,79084,ENSG00000116455.13,WDR77,1,,,snRNP Assembly; RMTs methylate histone arginines,6,High,1
Q9HD26,Golgi-associated PDZ and coiled-coil motif-containing protein OS=Homo sapiens OX=9606 GN=GOPC PE=1 SV=1,0,50.959,26,9,42,9,462,50.5,5.92,15989,,9,,cell organization and biogenesis;regulation of biological process;transport,cytoplasm;Golgi;membrane,DNA binding;protein binding,"Pf00595, Pf07716, Pf13180",57120,ENSG00000047932.13,GOPC,6,,,RHO GTPases regulate CFTR trafficking,4,High,1
Q9Y5K8,V-type proton ATPase subunit D OS=Homo sapiens OX=9606 GN=ATP6V1D PE=1 SV=1,0,50.915,33,7,33,7,247,28.2,9.36,11325,,7,,cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport,cytosol;membrane,catalytic activity;protein binding;transporter activity,Pf01813,51382,ENSG00000100554.11,ATP6V1D,14,Synaptic vesicle cycle; Metabolic pathways; mTOR signaling pathway; Rheumatoid arthritis; Epithelial cell signaling in Helicobacter pylori infection; Oxidative phosphorylation; Collecting duct acid secretion; Vibrio cholerae infection; Phagosome,,"Transferrin endocytosis and recycling; ROS, RNS production in phagocytes; Ion channel transport; Insulin receptor recycling; Neutrophil degranulation",21,High,1
P09497,Clathrin light chain B OS=Homo sapiens OX=9606 GN=CLTB PE=1 SV=1,0,50.803,23,9,128,9,229,25.2,4.64,53932,0,9,1,cell organization and biogenesis;transport,cytosol;membrane,protein binding;structural molecule activity,Pf01086,1212,ENSG00000175416.12,CLTB,5,Endocytosis; Bacterial invasion of epithelial cells; Huntington's disease; Lysosome; Synaptic vesicle cycle; Endocrine and other factor-regulated calcium reabsorption,,"EPH-ephrin mediated repulsion of cells; Cargo recognition for clathrin-mediated endocytosis; Formation of annular gap junctions; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Lysosome Vesicle Biogenesis; WNT5A-dependent internalization of FZD4",27,High,1
P49754,Vacuolar protein sorting-associated protein 41 homolog OS=Homo sapiens OX=9606 GN=VPS41 PE=1 SV=3,0,50.793,15,12,43,12,854,98.5,5.85,16610,,12,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoskeleton;cytosol;endosome;Golgi;membrane;vacuole,metal ion binding;protein binding,Pf00637,27072,ENSG00000006715.15,VPS41,7,,,,0,High,1
O95819,Mitogen-activated protein kinase kinase kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP4K4 PE=1 SV=2,0,50.591,12,11,48,5,1239,142,7.46,20555,,11,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm,catalytic activity;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf00780, Pf07714",9448,ENSG00000071054.16,MAP4K4,2,MAPK signaling pathway,MAPK Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; Insulin Signaling,Oxidative Stress Induced Senescence,8,High,1
Q9BPX5,Actin-related protein 2/3 complex subunit 5-like protein OS=Homo sapiens OX=9606 GN=ARPC5L PE=1 SV=1,0,50.555,59,7,86,6,153,16.9,6.6,40103,,7,,cell organization and biogenesis;cellular component movement;regulation of biological process,cytoplasm;cytoskeleton,protein binding,Pf04699,81873,ENSG00000136950.13,ARPC5L,9,Shigellosis; Regulation of actin cytoskeleton; Endocytosis; Fc gamma R-mediated phagocytosis; Salmonella infection; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection,Pathogenic Escherichia coli infection,,8,High,1
Q10471,Polypeptide N-acetylgalactosaminyltransferase 2 OS=Homo sapiens OX=9606 GN=GALNT2 PE=1 SV=1,0,50.551,24,11,44,11,571,64.7,8.35,16188,,11,,metabolic process,extracellular;Golgi;membrane,catalytic activity;metal ion binding;protein binding,"Pf00535, Pf00652",2590,ENSG00000143641.9,GALNT2,1,Metabolic pathways; Mucin type O-glycan biosynthesis,Globo Sphingolipid Metabolism,COPI-independent Golgi-to-ER retrograde traffic; O-linked glycosylation of mucins,12,High,1
Q969T9,WW domain-binding protein 2 OS=Homo sapiens OX=9606 GN=WBP2 PE=1 SV=1,0,50.509,39,8,107,8,261,28.1,5.91,47207,2.1,7,2,regulation of biological process;response to stimulus,cytoplasm;nucleus,DNA binding;protein binding,"Pf02893, Pf10349",23558,ENSG00000132471.11,WBP2,17,,,,0,High,1
O15511,Actin-related protein 2/3 complex subunit 5 OS=Homo sapiens OX=9606 GN=ARPC5 PE=1 SV=3,0,50.494,41,6,80,5,151,16.3,5.67,37875,,6,,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endosome;extracellular;organelle lumen,protein binding;structural molecule activity,Pf04699,10092,ENSG00000162704.15,ARPC5,1,Pathogenic Escherichia coli infection; Bacterial invasion of epithelial cells; Shigellosis; Salmonella infection; Endocytosis; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton,Pathogenic Escherichia coli infection; Regulation of Actin Cytoskeleton,EPHB-mediated forward signaling; Neutrophil degranulation; Clathrin-mediated endocytosis; RHO GTPases Activate WASPs and WAVEs; Regulation of actin dynamics for phagocytic cup formation,25,High,1
Q5T2T1,MAGUK p55 subfamily member 7 OS=Homo sapiens OX=9606 GN=MPP7 PE=1 SV=1,0,50.455,27,10,28,10,576,65.5,7.14,9909,0,10,2,cell organization and biogenesis;regulation of biological process,membrane,protein binding;structural molecule activity,"Pf00018, Pf00595, Pf00625, Pf02828, Pf07653, Pf13180, Pf14604, Pf14685",143098,ENSG00000150054.18,MPP7,10,,,,0,High,1
Q8TCD5,"5'(3')-deoxyribonucleotidase, cytosolic type OS=Homo sapiens OX=9606 GN=NT5C PE=1 SV=2",0,50.437,38,7,130,7,201,23.4,6.64,56872,0,7,1,metabolic process,cytoplasm;cytosol;mitochondrion;nucleus,catalytic activity;metal ion binding;nucleotide binding;receptor activity;signal transducer activity,Pf06941,30833,ENSG00000125458.6,NT5C,17,Nicotinate and nicotinamide metabolism; Pyrimidine metabolism; Purine metabolism; Metabolic pathways,,Pyrimidine catabolism; Purine catabolism,9,High,1
Q9NXR7,BRISC and BRCA1-A complex member 2 OS=Homo sapiens OX=9606 GN=BABAM2 PE=1 SV=2,0,50.437,34,9,49,9,383,43.5,5.81,18087,0,8,1,cell death;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,protein binding,Pf06113,9577,ENSG00000158019.20,BRE; BABAM2,2,Homologous recombination,,G2/M DNA damage checkpoint; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; Nonhomologous End-Joining (NHEJ); Metalloprotease DUBs,17,High,1
Q08379,Golgin subfamily A member 2 OS=Homo sapiens OX=9606 GN=GOLGA2 PE=1 SV=3,0,50.367,14,10,23,9,1002,113,5.02,10235,,10,,cell division;cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;Golgi;membrane;nucleus,catalytic activity;motor activity;protein binding,"Pf01576, Pf15070",2801,ENSG00000167110.17,GOLGA2,9,,,COPII (Coat Protein 2) Mediated Vesicle Transport; COPI-mediated anterograde transport; Golgi Cisternae Pericentriolar Stack Reorganization; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models,17,High,1
P55042,GTP-binding protein RAD OS=Homo sapiens OX=9606 GN=RRAD PE=1 SV=2,0,50.345,32,6,148,5,308,33.2,8.88,67177,9.75,4,2,regulation of biological process;response to stimulus,membrane,catalytic activity;nucleotide binding;protein binding,"Pf00071, Pf08477",6236,ENSG00000166592.11,RRAD,16,,Insulin Signaling,,1,High,1
P25098,Beta-adrenergic receptor kinase 1 OS=Homo sapiens OX=9606 GN=GRK2 PE=1 SV=2,0,50.339,20,12,37,12,689,79.5,7.28,16371,,12,,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding;receptor activity;signal transducer activity,"Pf00069, Pf00169, Pf00615, Pf07714",156,ENSG00000173020.10,ADRBK1; GRK2,11,Olfactory transduction; Hedgehog signaling pathway; Glutamatergic synapse; Morphine addiction; Endocytosis; Chemokine signaling pathway,Chemokine signaling pathway; Hedgehog Signaling Pathway,Cargo recognition for clathrin-mediated endocytosis; G alpha (s) signalling events; Activation of SMO; Gastrin-CREB signalling pathway via PKC and MAPK; Calmodulin induced events,29,High,1
Q9NP79,Vacuolar protein sorting-associated protein VTA1 homolog OS=Homo sapiens OX=9606 GN=VTA1 PE=1 SV=1,0,50.316,23,7,104,7,307,33.9,6.29,48693,0,7,1,cell communication;cell organization and biogenesis;metabolic process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane,protein binding,Pf04652,51534,ENSG00000009844.15,VTA1,6,Endocytosis,,Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT),10,High,1
P56539,Caveolin-3 OS=Homo sapiens OX=9606 GN=CAV3 PE=1 SV=1,0,50.301,36,7,203,3,151,17.2,5.78,96673,36.47,6,2,cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;endoplasmic reticulum;Golgi;membrane,protein binding;structural molecule activity,Pf01146,859,ENSG00000182533.6,CAV3,3,Bacterial invasion of epithelial cells; Endocytosis; Proteoglycans in cancer; Focal adhesion,Integrin-mediated Cell Adhesion; Focal Adhesion; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,Smooth Muscle Contraction,9,High,1
Q7L014,Probable ATP-dependent RNA helicase DDX46 OS=Homo sapiens OX=9606 GN=DDX46 PE=1 SV=2,0,50.298,13,12,47,12,1031,117.3,9.29,18182,,12,,metabolic process;regulation of biological process,cytoplasm;membrane;nucleus,catalytic activity;nucleotide binding;RNA binding,"Pf00270, Pf00271",9879,ENSG00000145833.15,DDX46,5,Spliceosome,,mRNA Splicing - Major Pathway,5,High,1
Q9NRZ7,1-acyl-sn-glycerol-3-phosphate acyltransferase gamma OS=Homo sapiens OX=9606 GN=AGPAT3 PE=1 SV=1,0,50.229,20,9,70,9,376,43.4,8.72,26771,,9,,metabolic process,endoplasmic reticulum;membrane;nucleus,catalytic activity,Pf01553,56894,ENSG00000160216.18,AGPAT3,21,Metabolic pathways; Glycerolipid metabolism; Glycerophospholipid metabolism; Phospholipase D signaling pathway,Triacylglyceride Synthesis,COPI-independent Golgi-to-ER retrograde traffic; Synthesis of PA,15,High,1
Q02809,"Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 OS=Homo sapiens OX=9606 GN=PLOD1 PE=1 SV=2",0,50.205,18,10,34,10,727,83.5,6.95,11938,,10,,metabolic process;response to stimulus,endoplasmic reticulum;membrane,catalytic activity;metal ion binding;protein binding,Pf03171,5351,ENSG00000083444.16,PLOD1,1,Lysine degradation,,Collagen biosynthesis and modifying enzymes,4,High,1
Q99538,Legumain OS=Homo sapiens OX=9606 GN=LGMN PE=1 SV=1,0,50.196,24,5,69,5,433,49.4,6.55,37720,2.95,4,1,metabolic process;regulation of biological process;response to stimulus,endosome;organelle lumen;vacuole,catalytic activity,Pf01650,5641,ENSG00000100600.14,LGMN,14,Antigen processing and presentation; Lysosome,,Vitamin D (calciferol) metabolism; MHC class II antigen presentation; Trafficking and processing of endosomal TLR,12,High,1
P62847,40S ribosomal protein S24 OS=Homo sapiens OX=9606 GN=RPS24 PE=1 SV=1,0,50.193,35,5,168,5,133,15.4,10.78,80586,1.73,5,1,cell organization and biogenesis;metabolic process;transport,cytosol;membrane;nucleus;ribosome,protein binding;RNA binding;structural molecule activity,Pf01282,6229,ENSG00000138326.18,RPS24,10,Ribosome,Cytoplasmic Ribosomal Proteins,"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane",38,High,1
P11117,Lysosomal acid phosphatase OS=Homo sapiens OX=9606 GN=ACP2 PE=1 SV=3,0,50.184,25,8,92,8,423,48.3,6.74,37302,,8,,cell organization and biogenesis;metabolic process,membrane;organelle lumen;vacuole,catalytic activity,Pf00328,53,ENSG00000134575.9,ACP2,11,Lysosome,,,1,High,1
Q14643,"Inositol 1,4,5-trisphosphate receptor type 1 OS=Homo sapiens OX=9606 GN=ITPR1 PE=1 SV=3",0,50.182,5,11,53,8,2758,313.7,6.04,20554,,11,,cell death;cellular homeostasis;regulation of biological process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;membrane,metal ion binding;protein binding;receptor activity;signal transducer activity;transporter activity,"Pf00520, Pf01365, Pf02815, Pf08454, Pf08709",3708,ENSG00000150995.18,ITPR1,3,GnRH signaling pathway; Proteoglycans in cancer; Oxytocin signaling pathway; Oocyte meiosis; Glucagon signaling pathway; Glutamatergic synapse; Estrogen signaling pathway; Alzheimer's disease; Circadian entrainment; Dopaminergic synapse; Gastric acid secretion; Thyroid hormone synthesis; cGMP-PKG signaling pathway; Cholinergic synapse; Long-term depression; Long-term potentiation; Serotonergic synapse; Salivary secretion; Pancreatic secretion; Renin secretion; Calcium signaling pathway; Aldosterone synthesis and secretion; Gap junction; NOD-like receptor signaling pathway; Inflammatory mediator regulation of TRP channels; Apoptosis; Huntington's disease; Platelet activation; Retrograde endocannabinoid signaling; Phosphatidylinositol signaling system; Vascular smooth muscle contraction,Alzheimers Disease; Myometrial Relaxation and Contraction Pathways; G Protein Signaling Pathways; Cell-type Dependent Selectivity of CCK2R Signaling; Calcium Regulation in the Cardiac Cell; T-Cell antigen Receptor (TCR)  Signaling Pathway; Serotonin Receptor 2 and ELK-SRF/GATA4 signaling,Ion homeostasis; FCERI mediated Ca+2 mobilization; PLC beta mediated events; Ca2+ pathway; cGMP effects; DAG and IP3 signaling; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Elevation of cytosolic Ca2+ levels; Effects of PIP2 hydrolysis; Gastrin-CREB signalling pathway via PKC and MAPK; VEGFR2 mediated cell proliferation; CLEC7A (Dectin-1) induces NFAT activation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of phospholipids in phagocytosis,82,High,1
Q8WWP7,GTPase IMAP family member 1 OS=Homo sapiens OX=9606 GN=GIMAP1 PE=1 SV=1,0,50.179,41,8,36,8,306,34.3,8.87,16321,2.46,7,1,,endoplasmic reticulum;Golgi;membrane,nucleotide binding,"Pf01926, Pf04548",170575,ENSG00000213203.2,GIMAP1,7,,,,0,High,1
P60866,40S ribosomal protein S20 OS=Homo sapiens OX=9606 GN=RPS20 PE=1 SV=1,0,50.162,24,6,124,6,119,13.4,9.94,60163,,6,,cell organization and biogenesis;metabolic process;transport,cytoplasm;cytosol;membrane;ribosome,protein binding;RNA binding;structural molecule activity,Pf00338,6224,ENSG00000008988.9,RPS20,8,Ribosome,Cytoplasmic Ribosomal Proteins,"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane",38,High,1
Q96FJ2,"Dynein light chain 2, cytoplasmic OS=Homo sapiens OX=9606 GN=DYNLL2 PE=1 SV=1",0,50.149,57,6,175,6,89,10.3,7.37,90625,28.1,4,3,cell communication;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus,catalytic activity;motor activity;protein binding,Pf01221,140735,ENSG00000264364.2,DYNLL2,17,Vasopressin-regulated water reabsorption,,COPI-independent Golgi-to-ER retrograde traffic; Activation of BMF and translocation to mitochondria; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Intraflagellar transport; RHO GTPases Activate Formins; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR); Macroautophagy,43,High,1
Q9UBE0,SUMO-activating enzyme subunit 1 OS=Homo sapiens OX=9606 GN=SAE1 PE=1 SV=1,0,50.11,37,9,55,9,346,38.4,5.3,23475,,9,,metabolic process;regulation of biological process,cytoplasm;nucleus,catalytic activity;enzyme regulator activity;protein binding,Pf00899,10055,ENSG00000142230.11,SAE1,19,Ubiquitin mediated proteolysis,,"SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9)",7,High,1
Q92530,Proteasome inhibitor PI31 subunit OS=Homo sapiens OX=9606 GN=PSMF1 PE=1 SV=2,0,50.093,36,9,97,9,271,29.8,5.74,41425,0,8,1,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;membrane;proteasome,enzyme regulator activity;protein binding,"Pf08577, Pf11566",9491,ENSG00000125818.17,PSMF1,20,Proteasome,,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,149,High,1
Q9NP90,Ras-related protein Rab-9B OS=Homo sapiens OX=9606 GN=RAB9B PE=1 SV=1,0,50.091,37,5,68,4,201,22.7,4.87,21649,34.01,5,4,regulation of biological process;response to stimulus;transport,cytosol;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf01926, Pf04670, Pf08477",51209,ENSG00000123570.3,RAB9B,X,Measles,,Retrograde transport at the Trans-Golgi-Network; Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation,13,High,1
O14653,Golgi SNAP receptor complex member 2 OS=Homo sapiens OX=9606 GN=GOSR2 PE=1 SV=2,0,50.037,43,5,48,5,212,24.8,8.06,24691,,5,,cell organization and biogenesis;transport,cytosol;endoplasmic reticulum;Golgi;membrane,protein binding,Pf12352,9570,ENSG00000108433.16,GOSR2,17,SNARE interactions in vesicular transport,,Intra-Golgi traffic; Cargo concentration in the ER; COPII (Coat Protein 2) Mediated Vesicle Transport; COPI-mediated anterograde transport; XBP1(S) activates chaperone genes,16,High,1
Q9UGV2,Protein NDRG3 OS=Homo sapiens OX=9606 GN=NDRG3 PE=1 SV=2,0,50.035,32,7,72,7,375,41.4,5.31,29907,0,7,1,cell differentiation;regulation of biological process;response to stimulus,cytoplasm,,"Pf00561, Pf03096, Pf12697",57446,ENSG00000101079.20,NDRG3,20,,,,0,High,1
Q14CX7,"N-alpha-acetyltransferase 25, NatB auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA25 PE=1 SV=1",0,49.989,13,11,38,11,972,112.2,6.64,15930,,11,,metabolic process,cytoplasm;cytosol;Golgi,catalytic activity;protein binding,Pf09797,80018,ENSG00000111300.9,NAA25,12,,,,0,High,1
O15085,Rho guanine nucleotide exchange factor 11 OS=Homo sapiens OX=9606 GN=ARHGEF11 PE=1 SV=1,0,49.979,10,13,41,13,1522,167.6,5.5,17545,,13,,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,enzyme regulator activity;protein binding,"Pf00595, Pf00615, Pf00621, Pf09128, Pf13180",9826,ENSG00000132694.18,ARHGEF11,1,Pathways in cancer; Vascular smooth muscle contraction,,G alpha (12/13) signalling events; NRAGE signals death through JNK; Sema4D induced cell migration and growth-cone collapse; Rho GTPase cycle; Signalling by NGF,18,High,1
O00161,Synaptosomal-associated protein 23 OS=Homo sapiens OX=9606 GN=SNAP23 PE=1 SV=1,0,49.809,51,8,36,8,211,23.3,5.01,16395,1.78,8,1,cell organization and biogenesis;metabolic process;transport,cytoplasm;extracellular;membrane;vacuole,catalytic activity;metal ion binding;protein binding,"Pf00835, Pf05739",8773,ENSG00000092531.9,SNAP23,15,Platelet activation; SNARE interactions in vesicular transport,Insulin Signaling,Translocation of GLUT4 to the plasma membrane; Clathrin derived vesicle budding; ER-Phagosome pathway; Neutrophil degranulation,15,High,1
O75962,Triple functional domain protein OS=Homo sapiens OX=9606 GN=TRIO PE=1 SV=2,0,49.808,4,10,51,8,3097,346.7,6.37,23877,3.7,9,1,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00018, Pf00047, Pf00069, Pf00169, Pf00435, Pf00621, Pf00650, Pf06293, Pf07653, Pf07679, Pf07714, Pf13716, Pf13895, Pf13927, Pf14604",7204,ENSG00000038382.18,TRIO,5,,Regulation of Microtubule Cytoskeleton,DCC mediated attractive signaling; G alpha (12/13) signalling events; NRAGE signals death through JNK; Gastrin-CREB signalling pathway via PKC and MAPK; Rho GTPase cycle; Signalling by NGF,18,High,1
P36404,ADP-ribosylation factor-like protein 2 OS=Homo sapiens OX=9606 GN=ARL2 PE=1 SV=4,0,49.769,48,7,84,7,184,20.9,6.34,37062,1.7,7,2,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;Golgi;mitochondrion;nucleus;organelle lumen,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding;signal transducer activity,"Pf00025, Pf00071, Pf00503, Pf01926, Pf04670, Pf08477, Pf09439",402,ENSG00000213465.7,ARL2,11,,,Post-chaperonin tubulin folding pathway; Regulation of insulin secretion,6,High,1
Q9Y5Y2,Cytosolic Fe-S cluster assembly factor NUBP2 OS=Homo sapiens OX=9606 GN=NUBP2 PE=1 SV=1,0,49.715,35,6,57,6,271,28.8,5.83,21909,,6,,cell organization and biogenesis;metabolic process,cytoplasm;cytoskeleton;nucleus,metal ion binding;nucleotide binding;protein binding,"Pf00142, Pf01656, Pf02374, Pf03308, Pf08433, Pf09140, Pf10609, Pf13481, Pf13614",10101,ENSG00000095906.16,NUBP2,16,,,Cytosolic iron-sulfur cluster assembly,2,High,1
Q4G0F5,Vacuolar protein sorting-associated protein 26B OS=Homo sapiens OX=9606 GN=VPS26B PE=1 SV=2,0,49.704,35,10,38,9,336,39.1,7.36,15850,0,10,1,regulation of biological process;transport,cytoplasm;cytosol;endosome;membrane,protein binding;transporter activity,Pf03643,112936,ENSG00000151502.10,VPS26B,11,Endocytosis,,,1,High,1
Q9UHB6,LIM domain and actin-binding protein 1 OS=Homo sapiens OX=9606 GN=LIMA1 PE=1 SV=1,0,49.671,19,10,25,10,759,85.2,6.84,10525,,10,,cell organization and biogenesis;regulation of biological process,cytoplasm;cytoskeleton,metal ion binding;protein binding,Pf00412,51474,ENSG00000050405.13,LIMA1,12,,,,0,High,1
Q9UK55,Protein Z-dependent protease inhibitor OS=Homo sapiens OX=9606 GN=SERPINA10 PE=1 SV=1,0,49.657,22,9,52,9,444,50.7,8.27,22175,,9,,coagulation;metabolic process;regulation of biological process,extracellular;organelle lumen,enzyme regulator activity,Pf00079,51156,ENSG00000278767.4; ENSG00000140093.9,SERPINA10,14; CHR_HSCHR14_7_CTG1,,,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs),4,High,1
O43747,AP-1 complex subunit gamma-1 OS=Homo sapiens OX=9606 GN=AP1G1 PE=1 SV=5,0,49.588,16,11,74,11,822,91.3,6.8,30491,,11,,cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytosol;endosome;Golgi;membrane,protein binding;transporter activity,"Pf01602, Pf02883",164,ENSG00000166747.12,AP1G1,16,Lysosome,,Nef mediated downregulation of MHC class I complex cell surface expression; MHC class II antigen presentation; Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis,17,High,1
P08185,Corticosteroid-binding globulin OS=Homo sapiens OX=9606 GN=SERPINA6 PE=1 SV=1,0,49.555,25,8,123,7,405,45.1,6.04,49425,,8,,metabolic process;regulation of biological process;transport,extracellular,enzyme regulator activity,Pf00079,866,ENSG00000170099.5; ENSG00000277405.2,SERPINA6,14; CHR_HSCHR14_7_CTG1,,,,0,High,1
Q96EL2,"28S ribosomal protein S24, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS24 PE=1 SV=1",0,49.5,33,4,101,4,167,19,9.38,44730,,4,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,RNA binding;structural molecule activity,Pf14955,64951,ENSG00000062582.13,MRPS24,7,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
Q13190,Syntaxin-5 OS=Homo sapiens OX=9606 GN=STX5 PE=1 SV=2,0,49.499,27,6,32,6,355,39.6,9.16,15298,,6,,cell organization and biogenesis;regulation of biological process;transport,cytosol;endoplasmic reticulum;Golgi;membrane,protein binding,"Pf00804, Pf05739",6811,ENSG00000162236.11,STX5,11,SNARE interactions in vesicular transport,,COPI-mediated anterograde transport; Intra-Golgi traffic; Cargo concentration in the ER; COPII (Coat Protein 2) Mediated Vesicle Transport,13,High,1
Q5MNZ9,WD repeat domain phosphoinositide-interacting protein 1 OS=Homo sapiens OX=9606 GN=WIPI1 PE=1 SV=3,0,49.368,33,7,33,7,446,48.6,6.6,11925,2.45,7,1,cell communication;metabolic process;response to stimulus,cytoplasm;cytoskeleton;cytosol;endosome;Golgi;membrane,protein binding,,55062,ENSG00000070540.12,WIPI1,17,,,XBP1(S) activates chaperone genes; Macroautophagy,6,High,1
P39210,Protein Mpv17 OS=Homo sapiens OX=9606 GN=MPV17 PE=1 SV=1,0,49.362,22,4,93,4,176,19.7,9.47,36633,0,4,1,cell organization and biogenesis;regulation of biological process;response to stimulus,membrane;mitochondrion,,Pf04117,4358,ENSG00000115204.14,MPV17,2,Peroxisome,,,1,High,1
Q9UGI8,Testin OS=Homo sapiens OX=9606 GN=TES PE=1 SV=1,0,49.349,19,8,64,8,421,48,7.68,27199,0,8,1,regulation of biological process,cytoplasm;cytosol;membrane;nucleus,metal ion binding;protein binding;RNA binding,"Pf00412, Pf06297",26136,ENSG00000135269.17,TES,7,,,,0,High,1
Q9UL15,BAG family molecular chaperone regulator 5 OS=Homo sapiens OX=9606 GN=BAG5 PE=1 SV=1,0,49.348,22,7,25,7,447,51.2,6.05,11318,1.73,7,1,cell death;cell organization and biogenesis;metabolic process;regulation of biological process,cytosol;membrane;mitochondrion;nucleus,enzyme regulator activity;nucleotide binding;protein binding,Pf02179,9529,ENSG00000166170.9,BAG5,14,,,Regulation of HSF1-mediated heat shock response,4,High,1
Q9Y6D6,Brefeldin A-inhibited guanine nucleotide-exchange protein 1 OS=Homo sapiens OX=9606 GN=ARFGEF1 PE=1 SV=2,0,49.34,6,11,35,4,1849,208.6,5.85,15441,,11,,cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytosol;Golgi;membrane;nucleus,enzyme regulator activity;protein binding,"Pf01369, Pf09324, Pf12783",10565,ENSG00000066777.8,ARFGEF1,8,Endocytosis,,,1,High,1
Q08174-2,Isoform 2 of Protocadherin-1 OS=Homo sapiens OX=9606 GN=PCDH1,0,49.258,13,11,31,11,1237,133.6,5.06,9862,5.64,9,3,cell communication,membrane;nucleus,metal ion binding,"Pf00028, Pf08266, Pf08374",5097,ENSG00000156453.13,PCDH1,5,,,,0,High,1
Q14956,Transmembrane glycoprotein NMB OS=Homo sapiens OX=9606 GN=GPNMB PE=1 SV=2,0,49.249,9,5,130,5,572,63.9,6.64,61939,2.53,5,1,cell communication;cell differentiation;regulation of biological process;response to stimulus,membrane,protein binding,Pf00801,10457,ENSG00000136235.15,GPNMB,7,,,PTK6 promotes HIF1A stabilization,4,High,1
P49770,Translation initiation factor eIF-2B subunit beta OS=Homo sapiens OX=9606 GN=EIF2B2 PE=1 SV=3,0,49.224,30,8,51,8,351,39,6.16,19439,,8,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,nucleotide binding;protein binding;RNA binding,Pf01008,8892,ENSG00000119718.10,EIF2B2,14,RNA transport,Translation Factors; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling,Recycling of eIF2:GDP,8,High,1
Q9HBK9,Arsenite methyltransferase OS=Homo sapiens OX=9606 GN=AS3MT PE=1 SV=3,0,49.203,26,10,71,10,375,41.7,6.2,28288,,10,,metabolic process,cytoplasm;cytosol;mitochondrion,catalytic activity,"Pf01135, Pf01209, Pf08241, Pf08242, Pf12847, Pf13489, Pf13649, Pf13659, Pf13847",57412,ENSG00000214435.7,AS3MT,10,,,Methylation,4,High,1
O60888,Protein CutA OS=Homo sapiens OX=9606 GN=CUTA PE=1 SV=2,0,49.189,30,3,64,3,179,19.1,5.5,28766,0,3,2,response to stimulus,membrane,metal ion binding;protein binding,Pf03091,51596,ENSG00000112514.15; ENSG00000226492.7,CUTA,6; CHR_HSCHR6_MHC_SSTO_CTG1,,,,0,High,1
P09012,U1 small nuclear ribonucleoprotein A OS=Homo sapiens OX=9606 GN=SNRPA PE=1 SV=3,0,49.166,30,7,77,5,282,31.3,9.83,39826,,7,,metabolic process;regulation of biological process,nucleus;spliceosomal complex,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",6626,ENSG00000077312.8,SNRPA,19,Spliceosome,mRNA Processing,mRNA Splicing - Major Pathway,6,High,1
Q9UI30,Multifunctional methyltransferase subunit TRM112-like protein OS=Homo sapiens OX=9606 GN=TRMT112 PE=1 SV=1,0,49.146,43,5,98,5,125,14.2,5.26,48434,,5,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,Pf03966,51504,ENSG00000173113.6,TRMT112,11,,,tRNA modification in the nucleus and cytosol; Eukaryotic Translation Termination; rRNA modification in the nucleus and cytosol; Methylation,13,High,1
Q14011,Cold-inducible RNA-binding protein OS=Homo sapiens OX=9606 GN=CIRBP PE=1 SV=1,0,49.099,38,6,130,6,172,18.6,9.51,56652,2.62,6,2,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;nucleus,protein binding;RNA binding;translation regulator activity,"Pf00076, Pf13893, Pf14259",1153,ENSG00000099622.13,CIRBP,19,,,,0,High,1
Q8N5I4,Dehydrogenase/reductase SDR family member on chromosome X OS=Homo sapiens OX=9606 GN=DHRSX PE=1 SV=2,0,49.092,35,9,44,9,330,36.4,9,18099,0,9,1,metabolic process;regulation of biological process,extracellular,catalytic activity,"Pf00106, Pf08659, Pf13561, Pf13941",207063,ENSG00000169084.13,DHRSX,X|Y; X,,,,0,High,1
Q96CU9,FAD-dependent oxidoreductase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FOXRED1 PE=1 SV=2,0,49.066,23,10,51,10,486,53.8,7.78,21050,,10,,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion,catalytic activity,Pf01266,55572,ENSG00000110074.10,FOXRED1,11,,,,0,High,1
Q8IWA5,Choline transporter-like protein 2 OS=Homo sapiens OX=9606 GN=SLC44A2 PE=1 SV=3,0,49.024,8,6,121,6,706,80.1,8.57,59182,,6,,metabolic process;regulation of biological process;response to stimulus;transport,membrane,signal transducer activity;transporter activity,Pf04515,57153,ENSG00000129353.14,SLC44A2,19,Choline metabolism in cancer,,"Synthesis of PC; Transport of bile salts and organic acids, metal ions and amine compounds; Neutrophil degranulation",12,High,1
O75879,"Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial OS=Homo sapiens OX=9606 GN=GATB PE=1 SV=1",0,48.98,22,9,56,9,557,61.8,8.63,23798,,9,,cell organization and biogenesis;metabolic process,mitochondrion,catalytic activity;nucleotide binding;RNA binding,"Pf02637, Pf02934",5188,ENSG00000059691.11,PET112; GATB,4,Metabolic pathways; Aminoacyl-tRNA biosynthesis,,,2,High,1
P00813,Adenosine deaminase OS=Homo sapiens OX=9606 GN=ADA PE=1 SV=3,0,48.942,25,8,43,8,363,40.7,5.95,17480,0,8,1,cell differentiation;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;cytosol;membrane;organelle lumen;vacuole,catalytic activity;metal ion binding;protein binding,Pf00962,100,ENSG00000196839.12,ADA,20,Metabolic pathways; Primary immunodeficiency; Purine metabolism,,Purine salvage,7,High,1
Q9HC98,Serine/threonine-protein kinase Nek6 OS=Homo sapiens OX=9606 GN=NEK6 PE=1 SV=2,0,48.911,19,6,80,1,313,35.7,8.03,34747,,6,,cell death;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf07714, Pf14531",10783,ENSG00000119408.16,NEK6,9,,,"Activation of NIMA Kinases NEK9, NEK6, NEK7; Nuclear Pore Complex (NPC) Disassembly",7,High,1
Q07020,60S ribosomal protein L18 OS=Homo sapiens OX=9606 GN=RPL18 PE=1 SV=2,0,48.903,35,7,242,7,188,21.6,11.72,115584,4.82,6,1,cell organization and biogenesis;metabolic process;transport,cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;ribosome,RNA binding;structural molecule activity,Pf00828,6141,ENSG00000063177.12,RPL18,19,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
Q6UXN9,WD repeat-containing protein 82 OS=Homo sapiens OX=9606 GN=WDR82 PE=1 SV=1,0,48.857,27,7,68,7,313,35.1,7.69,31146,,7,,cell organization and biogenesis;metabolic process,chromosome;membrane;nucleus,catalytic activity;protein binding,Pf00400,80335,ENSG00000164091.11,WDR82,3,mRNA surveillance pathway,,,1,High,1
P53634,Dipeptidyl peptidase 1 OS=Homo sapiens OX=9606 GN=CTSC PE=1 SV=2,0,48.824,16,7,55,7,463,51.8,6.99,21364,0,7,1,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;extracellular;Golgi;membrane;organelle lumen;vacuole,catalytic activity;enzyme regulator activity;protein binding,"Pf00112, Pf03051, Pf08773",1075,ENSG00000109861.15,CTSC,11,Lysosome; Apoptosis,,Neutrophil degranulation; MHC class II antigen presentation; Cargo concentration in the ER; COPII (Coat Protein 2) Mediated Vesicle Transport,16,High,1
Q92820,Gamma-glutamyl hydrolase OS=Homo sapiens OX=9606 GN=GGH PE=1 SV=2,0,48.794,29,8,62,8,318,35.9,7.11,23228,,8,,metabolic process;response to stimulus;transport,cytosol;extracellular;nucleus;organelle lumen;vacuole,catalytic activity,"Pf00117, Pf07722",8836,ENSG00000137563.11,GGH,8,Antifolate resistance; Folate biosynthesis,Fluoropyrimidine Activity,Neutrophil degranulation,6,High,1
Q3KQV9,UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 OS=Homo sapiens OX=9606 GN=UAP1L1 PE=1 SV=2,0,48.738,21,8,50,7,507,57,6.32,23856,,8,,metabolic process,cytosol,catalytic activity,Pf01704,91373,ENSG00000197355.10,UAP1L1,9,Metabolic pathways; Amino sugar and nucleotide sugar metabolism,,,2,High,1
Q9BVK6,Transmembrane emp24 domain-containing protein 9 OS=Homo sapiens OX=9606 GN=TMED9 PE=1 SV=2,0,48.731,23,5,84,4,235,27.3,8.02,39626,,5,,cell organization and biogenesis;regulation of biological process;transport,endoplasmic reticulum;Golgi;membrane,protein binding,Pf01105,54732,ENSG00000184840.11,TMED9,5,,,COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport,11,High,1
Q53S58,Transmembrane protein 177 OS=Homo sapiens OX=9606 GN=TMEM177 PE=1 SV=1,0,48.711,24,6,48,6,311,33.7,9.61,19146,7.45,6,1,,membrane,,,80775,ENSG00000144120.12,TMEM177,2,,,,0,High,1
P01721,Immunoglobulin lambda variable 6-57 OS=Homo sapiens OX=9606 GN=IGLV6-57 PE=1 SV=2,0,48.676,50,4,49,4,117,12.6,4.78,22256,,4,,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity,Pf07686,28778,ENSG00000211640.4,IGLV6-57,22,,,FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis,26,High,1
Q13155,Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 OS=Homo sapiens OX=9606 GN=AIMP2 PE=1 SV=2,0,48.666,26,6,90,6,320,35.3,8.22,40273,,6,,cell death;cell differentiation;cell organization and biogenesis;development;metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;nucleus,protein binding;structural molecule activity,"Pf13410, Pf14497",7965,ENSG00000106305.9,AIMP2,7,,Osteoclast Signaling; Transcriptional activation by NRF2,Cytosolic tRNA aminoacylation; SeMet incorporation into proteins,10,High,1
O94915,Protein furry homolog-like OS=Homo sapiens OX=9606 GN=FRYL PE=1 SV=2,0,48.659,5,12,54,10,3013,339.4,5.58,20271,,12,,cell organization and biogenesis;metabolic process;regulation of biological process,,,"Pf14222, Pf14225, Pf14228",285527,ENSG00000075539.13,FRYL,4,,,,0,High,1
P23434,"Glycine cleavage system H protein, mitochondrial OS=Homo sapiens OX=9606 GN=GCSH PE=1 SV=2",0,48.57,17,2,61,2,173,18.9,4.88,32074,10.69,2,1,metabolic process,mitochondrion;organelle lumen,catalytic activity;protein binding,Pf01597,2653,ENSG00000140905.10,GCSH,16,"Glyoxylate and dicarboxylate metabolism; Glycine, serine and threonine metabolism; Metabolic pathways",,Glycine degradation,7,High,1
P31751,RAC-beta serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=AKT2 PE=1 SV=2,0,48.523,26,11,72,9,481,55.7,6.37,34307,1.61,10,1,cell death;cell differentiation;cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf00169, Pf00433, Pf07714, Pf14531, Pf15413",208,ENSG00000105221.16,AKT2,19,Pancreatic cancer; Breast cancer; Apoptosis; Fc gamma R-mediated phagocytosis; Tight junction; Rap1 signaling pathway; Glucagon signaling pathway; Small cell lung cancer; Longevity regulating pathway; Longevity regulating pathway - multiple species; Neurotrophin signaling pathway; Adrenergic signaling in cardiomyocytes; Carbohydrate digestion and absorption; Regulation of lipolysis in adipocytes; Prolactin signaling pathway; ErbB signaling pathway; Jak-STAT signaling pathway; Chemokine signaling pathway; HIF-1 signaling pathway; MAPK signaling pathway; HTLV-I infection; Hepatitis C; Platinum drug resistance; TNF signaling pathway; VEGF signaling pathway; Renal cell carcinoma; Sphingolipid signaling pathway; Cholinergic synapse; Dopaminergic synapse; Chronic myeloid leukemia; Thyroid hormone signaling pathway; AMPK signaling pathway; Influenza A; Hepatitis B; Non-small cell lung cancer; Melanoma; Toll-like receptor signaling pathway; PI3K-Akt signaling pathway; Phospholipase D signaling pathway; Pathways in cancer; Proteoglycans in cancer; Signaling pathways regulating pluripotency of stem cells; Osteoclast differentiation; Acute myeloid leukemia; Tuberculosis; Measles; Adipocytokine signaling pathway; FoxO signaling pathway; Colorectal cancer; Focal adhesion; Endocrine resistance; T cell receptor signaling pathway; B cell receptor signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Non-alcoholic fatty liver disease (NAFLD); Insulin resistance; Central carbon metabolism in cancer; Endometrial cancer; Toxoplasmosis; Ras signaling pathway; Chagas disease (American trypanosomiasis); Epstein-Barr virus infection; Glioma; mTOR signaling pathway; Estrogen signaling pathway; Insulin signaling pathway; Progesterone-mediated oocyte maturation; EGFR tyrosine kinase inhibitor resistance; Fc epsilon RI signaling pathway; Platelet activation; cGMP-PKG signaling pathway; Prostate cancer; Choline metabolism in cancer; cAMP signaling pathway,AMP-activated Protein Kinase (AMPK) Signaling; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; TFs Regulate miRNAs related to cardiac hypertrophy; Integrin-mediated Cell Adhesion; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway; Signaling Pathways in Glioblastoma; Signal Transduction of S1P Receptor; Cardiac Hypertrophic Response; Focal Adhesion; MAPK Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; Chemokine signaling pathway; ESC Pluripotency Pathways; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Insulin Signaling; Toll-like receptor signaling pathway,Regulation of PTEN stability and activity; Activation of AKT2; CTLA4 inhibitory signaling; G beta:gamma signalling through PI3Kgamma; Translocation of GLUT4 to the plasma membrane; AKT phosphorylates targets in the nucleus; Inhibition of TSC complex formation by PKB; AKT phosphorylates targets in the cytosol; Regulation of TP53 Activity through Association with Co-factors; Regulation of TP53 Activity through Acetylation; Regulation of TP53 Degradation; Negative regulation of the PI3K/AKT network; Activation of BAD and translocation to mitochondria ; RAB GEFs exchange GTP for GDP on RABs; Constitutive Signaling by AKT1 E17K in Cancer; Downregulation of ERBB2:ERBB3 signaling; Deactivation of the beta-catenin transactivating complex; Cyclin E associated events during G1/S transition ; GPVI-mediated activation cascade; CD28 dependent PI3K/Akt signaling; VEGFR2 mediated vascular permeability; AKT-mediated inactivation of FOXO1A; PDE3B signalling; RUNX2 regulates genes involved in cell migration; TP53 Regulates Metabolic Genes,170,High,1
P84157,Matrix-remodeling-associated protein 7 OS=Homo sapiens OX=9606 GN=MXRA7 PE=1 SV=1,0,48.439,39,5,33,1,204,21.5,4.26,20561,,5,,,membrane,,,439921,ENSG00000182534.13,MXRA7,17,,,,0,High,1
P09488,Glutathione S-transferase Mu 1 OS=Homo sapiens OX=9606 GN=GSTM1 PE=1 SV=3,0,48.438,33,8,142,1,218,25.7,6.7,58685,,8,,metabolic process;response to stimulus,cytoplasm;cytosol,catalytic activity;protein binding,"Pf00043, Pf02798, Pf13417, Pf14497",2944,ENSG00000134184.12,GSTM1,1,Metabolism of xenobiotics by cytochrome P450; Chemical carcinogenesis; Glutathione metabolism; Drug metabolism - cytochrome P450; Platinum drug resistance,Glutathione metabolism; NRF2 pathway; Benzene metabolism; Estrogen metabolism; Aflatoxin B1 metabolism; Metapathway biotransformation,Glutathione conjugation,15,High,1
P46937,Transcriptional coactivator YAP1 OS=Homo sapiens OX=9606 GN=YAP1 PE=1 SV=2,0,48.437,23,7,30,6,504,54.4,5.17,12619,,7,,cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,DNA binding;protein binding,Pf00397,10413,ENSG00000137693.13,YAP1,11,Hippo signaling pathway; Hippo signaling pathway -multiple species,Mesodermal Commitment Pathway; Rac1/Pak1/p38/MMP-2 pathway; TGF-beta Signaling Pathway; miR-509-3p alteration of YAP1/ECM axis,RUNX2 regulates osteoblast differentiation; Signaling by Hippo; RUNX1 regulates transcription of genes involved in differentiation of HSCs; YAP1- and WWTR1 (TAZ)-stimulated gene expression; Nuclear signaling by ERBB4; PPARA activates gene expression; RUNX3 regulates YAP1-mediated transcription,26,High,1
P04430,Immunoglobulin kappa variable 1-16 OS=Homo sapiens OX=9606 GN=IGKV1-16 PE=1 SV=2,0,48.411,48,5,56,2,117,12.6,8.16,29227,,5,,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity,"Pf00047, Pf07679, Pf07686, Pf13927",28938,ENSG00000282282.1; ENSG00000240864.3,IGKV1-16,CHR_HG2290_PATCH; 2,,,FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis,26,High,1
O14556,"Glyceraldehyde-3-phosphate dehydrogenase, testis-specific OS=Homo sapiens OX=9606 GN=GAPDHS PE=1 SV=2",0,48.382,6,7,2732,1,408,44.5,8.19,1382357,0,7,1,cellular component movement;metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00044, Pf02800, Pf02826",26330,ENSG00000105679.8,GAPDHS,19,Glycolysis / Gluconeogenesis; Metabolic pathways,Glycolysis and Gluconeogenesis,Gluconeogenesis; Glycolysis; Association of TriC/CCT with target proteins during biosynthesis,12,High,1
Q16270,Insulin-like growth factor-binding protein 7 OS=Homo sapiens OX=9606 GN=IGFBP7 PE=1 SV=1,0,48.343,23,5,67,5,282,29.1,7.9,26798,0,4,1,metabolic process;regulation of biological process;response to stimulus,extracellular;organelle lumen,protein binding,"Pf07648, Pf07679",3490,ENSG00000163453.11,IGFBP7,4,,Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway; VEGFA-VEGFR2 Signaling Pathway; Senescence and Autophagy in Cancer,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Senescence-Associated Secretory Phenotype (SASP),11,High,1
P07602,Prosaposin OS=Homo sapiens OX=9606 GN=PSAP PE=1 SV=2,0,48.337,10,7,194,7,524,58.1,5.17,94351,0,7,1,cell differentiation;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane;mitochondrion;organelle lumen;vacuole,catalytic activity;enzyme regulator activity;protein binding,"Pf02199, Pf03489, Pf05184",5660,ENSG00000197746.13,PSAP,10,Lysosome,,Platelet degranulation ; Peptide ligand-binding receptors; Neutrophil degranulation; Glycosphingolipid metabolism,17,High,1
O95989,Diphosphoinositol polyphosphate phosphohydrolase 1 OS=Homo sapiens OX=9606 GN=NUDT3 PE=1 SV=1,0,48.283,35,5,75,5,172,19.5,6.34,26994,,5,,cell communication;metabolic process,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding,Pf00293,11165,ENSG00000272325.1,NUDT3,6,,,Synthesis of pyrophosphates in the cytosol,3,High,1
Q8WWM7,Ataxin-2-like protein OS=Homo sapiens OX=9606 GN=ATXN2L PE=1 SV=2,0,48.278,13,10,28,10,1075,113.3,8.59,9738,0,10,1,cell organization and biogenesis;regulation of biological process,cytoplasm;cytosol;membrane;nucleus,protein binding;RNA binding,"Pf06741, Pf07145, Pf09770, Pf14438",11273,ENSG00000168488.18,ATXN2L,16,,,,0,High,1
Q9Y333,U6 snRNA-associated Sm-like protein LSm2 OS=Homo sapiens OX=9606 GN=LSM2 PE=1 SV=1,0,48.25,56,5,63,5,95,10.8,6.52,34871,,5,,metabolic process,cytosol;nucleus;spliceosomal complex,protein binding;RNA binding,Pf01423,57819,ENSG00000204392.10; ENSG00000236826.7; ENSG00000231502.6; ENSG00000224979.6; ENSG00000172850.11; ENSG00000225998.6,LSM2,6; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_APD_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_MCF_CTG1,RNA degradation; Spliceosome,mRNA Processing,mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; mRNA decay by 5' to 3' exoribonuclease,10,High,1
P27708,CAD protein OS=Homo sapiens OX=9606 GN=CAD PE=1 SV=3,0,48.228,8,13,50,13,2225,242.8,6.46,21173,,13,,metabolic process,cytoplasm;cytosol;membrane;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00117, Pf00185, Pf00289, Pf00988, Pf01979, Pf02142, Pf02222, Pf02729, Pf02786, Pf02787, Pf07478, Pf07722, Pf13147, Pf13535, Pf13594, Pf15632",790,ENSG00000084774.13,CAD,2,"Alanine, aspartate and glutamate metabolism; Metabolic pathways; Pyrimidine metabolism",Endothelin Pathways; Amino Acid metabolism,Pyrimidine biosynthesis,9,High,1
Q9BWF3,RNA-binding protein 4 OS=Homo sapiens OX=9606 GN=RBM4 PE=1 SV=1,0,48.215,30,7,29,7,364,40.3,7.08,16169,,7,,cell differentiation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,metal ion binding;protein binding;RNA binding,"Pf00076, Pf00098, Pf13893, Pf14259",5936,ENSG00000173933.19,RBM4,11,,,"BMAL1:CLOCK,NPAS2 activates circadian gene expression",2,High,1
Q8WWY3,U4/U6 small nuclear ribonucleoprotein Prp31 OS=Homo sapiens OX=9606 GN=PRPF31 PE=1 SV=2,0,48.193,32,10,35,10,499,55.4,5.78,14319,,10,,cell organization and biogenesis;metabolic process,nucleus;spliceosomal complex,protein binding;RNA binding,"Pf01798, Pf08060, Pf09785",26121,ENSG00000275117.4; ENSG00000277953.4; ENSG00000105618.13; ENSG00000277154.4; ENSG00000274894.4; ENSG00000274651.4; ENSG00000277707.4; ENSG00000276421.4; ENSG00000274144.4; ENSG00000275885.4,PRPF31,19; CHR_HSCHR19LRC_COX2_CTG3_1; CHR_HSCHR19LRC_LRC_T_CTG3_1; CHR_HSCHR19LRC_COX1_CTG3_1; CHR_HSCHR19LRC_LRC_J_CTG3_1; CHR_HSCHR19LRC_LRC_I_CTG3_1; CHR_HSCHR19LRC_PGF1_CTG3_1; CHR_HSCHR19LRC_LRC_S_CTG3_1; CHR_HSCHR19LRC_PGF2_CTG3_1; CHR_HSCHR19_4_CTG3_1,Spliceosome,,mRNA Splicing - Major Pathway,5,High,1
Q6P1N0,Coiled-coil and C2 domain-containing protein 1A OS=Homo sapiens OX=9606 GN=CC2D1A PE=1 SV=1,0,48.192,15,12,33,12,951,104,8.09,13316,,12,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,DNA binding;protein binding;signal transducer activity,Pf00168,54862,ENSG00000132024.17,CC2D1A,19,,Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,,1,High,1
Q9Y6M1,Insulin-like growth factor 2 mRNA-binding protein 2 OS=Homo sapiens OX=9606 GN=IGF2BP2 PE=1 SV=2,0,48.168,16,8,42,7,599,66.1,8.46,17960,,8,,regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;nucleus,protein binding;RNA binding;translation regulator activity,"Pf00013, Pf00076, Pf13014, Pf13083, Pf13893, Pf14259",10644,ENSG00000073792.15,IGF2BP2,3,,,Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA,2,High,1
Q15437,Protein transport protein Sec23B OS=Homo sapiens OX=9606 GN=SEC23B PE=1 SV=2,0,48.163,10,6,63,3,767,86.4,6.89,33337,,6,,transport,cytoplasm;cytosol;endoplasmic reticulum;membrane,metal ion binding;protein binding,"Pf00626, Pf04810, Pf04811, Pf04815, Pf08033",10483,ENSG00000101310.14,SEC23B,20,Protein processing in endoplasmic reticulum,Sterol Regulatory Element-Binding Proteins (SREBP) signalling,,2,High,1
P55083,Microfibril-associated glycoprotein 4 OS=Homo sapiens OX=9606 GN=MFAP4 PE=1 SV=2,0,48.123,31,6,158,5,255,28.6,5.63,70817,0,6,1,cell organization and biogenesis;regulation of biological process;response to stimulus,extracellular,protein binding,Pf00147,4239,ENSG00000166482.11,MFAP4,17,,,Molecules associated with elastic fibres,3,High,1
P13051,Uracil-DNA glycosylase OS=Homo sapiens OX=9606 GN=UNG PE=1 SV=2,0,48.105,30,6,64,6,313,34.6,9.32,26045,,6,,metabolic process;regulation of biological process;response to stimulus,mitochondrion;nucleus,catalytic activity;DNA binding;protein binding,Pf03167,7374,ENSG00000076248.10,UNG,12,Primary immunodeficiency; Base excision repair,,Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Displacement of DNA glycosylase by APEX1,10,High,1
Q8WVM0,"Dimethyladenosine transferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=TFB1M PE=1 SV=1",0,48.091,36,8,43,8,346,39.5,9.26,20098,,8,,cell organization and biogenesis;metabolic process;regulation of biological process,mitochondrion;organelle lumen,catalytic activity;DNA binding;protein binding;RNA binding,Pf00398,51106,ENSG00000029639.10,TFB1M,6,,Energy Metabolism; Mitochondrial Gene Expression,Transcriptional activation of mitochondrial biogenesis; rRNA modification in the mitochondrion,9,High,1
P49790,Nuclear pore complex protein Nup153 OS=Homo sapiens OX=9606 GN=NUP153 PE=1 SV=2,0,48.09,10,9,32,9,1475,153.8,8.73,14230,,9,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytosol;membrane;nucleus,DNA binding;metal ion binding;protein binding;structural molecule activity;transporter activity,"Pf00641, Pf08604, Pf10599",9972,ENSG00000124789.11,NUP153,6,RNA transport,TGF-beta Signaling Pathway,Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins,65,High,1
Q12805,EGF-containing fibulin-like extracellular matrix protein 1 OS=Homo sapiens OX=9606 GN=EFEMP1 PE=1 SV=2,0,48.079,16,6,71,6,493,54.6,5.07,29131,,6,,metabolic process;regulation of biological process;response to stimulus,cell surface;extracellular;membrane,catalytic activity;metal ion binding;protein binding;receptor activity;signal transducer activity,"Pf06247, Pf07645, Pf12662, Pf12947, Pf14670",2202,ENSG00000115380.19,EFEMP1,2,,,Molecules associated with elastic fibres,3,High,1
Q16850,Lanosterol 14-alpha demethylase OS=Homo sapiens OX=9606 GN=CYP51A1 PE=1 SV=3,0,48.064,23,10,47,10,503,56.8,8.53,20443,,10,,metabolic process;regulation of biological process,endoplasmic reticulum;membrane,catalytic activity;metal ion binding,Pf00067,1595,,CYP51A1,7,Metabolic pathways; Steroid biosynthesis,Cholesterol Biosynthesis; Sterol Regulatory Element-Binding Proteins (SREBP) signalling; Oxidation by Cytochrome P450; Metapathway biotransformation,Cholesterol biosynthesis; Endogenous sterols; Activation of gene expression by SREBF (SREBP),16,High,1
O43583,Density-regulated protein OS=Homo sapiens OX=9606 GN=DENR PE=1 SV=2,0,48.058,33,7,51,7,198,22.1,5.3,20815,3.54,6,1,cell organization and biogenesis;metabolic process,ribosome,protein binding;RNA binding,Pf01253,8562,ENSG00000139726.10,DENR,12,,,,0,High,1
Q8IUX7,Adipocyte enhancer-binding protein 1 OS=Homo sapiens OX=9606 GN=AEBP1 PE=1 SV=1,0,48.057,12,10,42,10,1158,130.8,5.11,17100,0,10,2,metabolic process;regulation of biological process,cytoplasm;extracellular;nucleus,catalytic activity;DNA binding;metal ion binding;protein binding,"Pf00246, Pf00754, Pf08400, Pf13620, Pf13715",165,ENSG00000106624.10,AEBP1,7,,,,0,High,1
Q86YZ3,Hornerin OS=Homo sapiens OX=9606 GN=HRNR PE=1 SV=2,0,48.054,11,5,23,5,2850,282.2,10.04,9563,,5,,cell organization and biogenesis;development;transport,cytoplasm;cytoskeleton;extracellular;nucleus;organelle lumen,metal ion binding,,388697,ENSG00000197915.5,HRNR,1,,,Neutrophil degranulation,3,High,1
Q5SRE7,Phytanoyl-CoA dioxygenase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PHYHD1 PE=1 SV=2,0,48.016,45,9,35,9,291,32.4,6.32,15291,,9,,metabolic process,,catalytic activity;metal ion binding;protein binding,Pf05721,254295,ENSG00000175287.18,PHYHD1,9,,,,0,High,1
Q13017,Rho GTPase-activating protein 5 OS=Homo sapiens OX=9606 GN=ARHGAP5 PE=1 SV=2,0,48.004,11,10,30,10,1502,172.4,6.62,12490,,10,,regulation of biological process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;membrane,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding,"Pf00071, Pf00620, Pf01846",394,ENSG00000100852.12,ARHGAP5,14,Focal adhesion; Leukocyte transendothelial migration,Focal Adhesion,Rho GTPase cycle,6,High,1
P33151,Cadherin-5 OS=Homo sapiens OX=9606 GN=CDH5 PE=1 SV=5,0,47.989,15,10,76,10,784,87.5,5.43,25195,,10,,cell organization and biogenesis;regulation of biological process;response to stimulus,cell surface;membrane,metal ion binding;protein binding,"Pf00028, Pf01049",1003,ENSG00000179776.17,CDH5,16,Cell adhesion molecules (CAMs); Leukocyte transendothelial migration,VEGFA-VEGFR2 Signaling Pathway,VEGFR2 mediated vascular permeability; Adherens junctions interactions,12,High,1
P15088,Mast cell carboxypeptidase A OS=Homo sapiens OX=9606 GN=CPA3 PE=1 SV=2,0,47.969,16,7,142,7,417,48.6,9,63575,,7,,metabolic process;regulation of biological process,extracellular,catalytic activity;metal ion binding,"Pf00246, Pf02244",1359,ENSG00000163751.3,CPA3,3,Pancreatic secretion; Protein digestion and absorption; Renin-angiotensin system,,Metabolism of Angiotensinogen to Angiotensins,6,High,1
P04181,"Ornithine aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=OAT PE=1 SV=1",0,47.957,28,10,51,10,439,48.5,7.03,22682,,10,,cell organization and biogenesis;metabolic process,cytoplasm;mitochondrion;organelle lumen,catalytic activity;protein binding,Pf00202,4942,ENSG00000065154.11,OAT,10,Metabolic pathways; Arginine and proline metabolism,Amino Acid metabolism; Urea cycle and metabolism of amino groups,Amino acid synthesis and interconversion (transamination),7,High,1
P27986,Phosphatidylinositol 3-kinase regulatory subunit alpha OS=Homo sapiens OX=9606 GN=PIK3R1 PE=1 SV=2,0,47.955,20,11,41,9,724,83.5,6.16,15430,,11,,cell death;cell differentiation;cellular component movement;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding,"Pf00017, Pf00018, Pf00620",5295,ENSG00000145675.14,PIK3R1,5,Epstein-Barr virus infection; Prostate cancer; AMPK signaling pathway; Fc gamma R-mediated phagocytosis; FoxO signaling pathway; Colorectal cancer; Apoptosis; Toll-like receptor signaling pathway; Longevity regulating pathway; Amoebiasis; Insulin signaling pathway; Progesterone-mediated oocyte maturation; Melanoma; Sphingolipid signaling pathway; Estrogen signaling pathway; B cell receptor signaling pathway; Glioma; Aldosterone-regulated sodium reabsorption; Chemokine signaling pathway; cGMP-PKG signaling pathway; ErbB signaling pathway; Proteoglycans in cancer; Hepatitis C; Platinum drug resistance; TNF signaling pathway; Central carbon metabolism in cancer; Endometrial cancer; HTLV-I infection; Measles; Insulin resistance; Chagas disease (American trypanosomiasis); Rap1 signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Leukocyte transendothelial migration; cAMP signaling pathway; Prolactin signaling pathway; Type II diabetes mellitus; Focal adhesion; Fc epsilon RI signaling pathway; PI3K-Akt signaling pathway; VEGF signaling pathway; Phosphatidylinositol signaling system; Carbohydrate digestion and absorption; Axon guidance; Osteoclast differentiation; Pancreatic cancer; Breast cancer; Toxoplasmosis; Small cell lung cancer; Cholinergic synapse; Neurotrophin signaling pathway; Thyroid hormone signaling pathway; mTOR signaling pathway; Endocrine resistance; T cell receptor signaling pathway; HIF-1 signaling pathway; Oxytocin signaling pathway; EGFR tyrosine kinase inhibitor resistance; Bacterial invasion of epithelial cells; Regulation of lipolysis in adipocytes; Chronic myeloid leukemia; Pathways in cancer; Choline metabolism in cancer; Ras signaling pathway; Longevity regulating pathway - multiple species; Hepatitis B; Non-small cell lung cancer; Renal cell carcinoma; Non-alcoholic fatty liver disease (NAFLD); Influenza A; Phospholipase D signaling pathway; Natural killer cell mediated cytotoxicity; Jak-STAT signaling pathway; Inflammatory mediator regulation of TRP channels; Platelet activation; Viral carcinogenesis; Acute myeloid leukemia; Adrenergic signaling in cardiomyocytes; Regulation of actin cytoskeleton; Signaling pathways regulating pluripotency of stem cells,IL-5 Signaling Pathway; Androgen receptor signaling pathway; AMP-activated Protein Kinase (AMPK) Signaling; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; Human Thyroid Stimulating Hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin Signaling Pathway; IL-7 Signaling Pathway; IL-9 Signaling Pathway; Signaling Pathways in Glioblastoma; B Cell Receptor Signaling Pathway; Interleukin-11 Signaling Pathway; Oncostatin M Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Alpha 6 Beta 4 signaling pathway; Apoptosis; Bladder Cancer; IL-3 Signaling Pathway; Kit receptor signaling pathway; Focal Adhesion; Rac1/Pak1/p38/MMP-2 pathway; IL-6 signaling pathway; TGF-beta Signaling Pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; Chemokine signaling pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Microglia Pathogen Phagocytosis Pathway; IL-4 Signaling Pathway; EGF/EGFR Signaling Pathway; Insulin Signaling; IL-2 Signaling Pathway; Regulation of Actin Cytoskeleton; Interferon type I signaling pathways; Notch Signaling Pathway; T-Cell antigen Receptor (TCR)  Signaling Pathway; DNA Damage Response (only ATM dependent); Toll-like receptor signaling pathway,"PI3K Cascade; Signaling by FGFR4 in disease; Downstream TCR signaling; PI-3K cascade:FGFR3; PI3K events in ERBB4 signaling; DAP12 signaling; PI-3K cascade:FGFR4; Regulation of signaling by CBL; Signaling by cytosolic FGFR1 fusion mutants; MET activates PI3K/AKT signaling; Role of phospholipids in phagocytosis; G alpha (12/13) signalling events; Constitutive Signaling by EGFRvIII; VEGFA-VEGFR2 Pathway; Interleukin receptor SHC signaling; GPVI-mediated activation cascade; CD28 dependent PI3K/Akt signaling; PI-3K cascade:FGFR2; RET signaling; Synthesis of PIPs at the plasma membrane; PI3K events in ERBB2 signaling; PI-3K cascade:FGFR1; Interleukin-4 and 13 signaling; Role of LAT2/NTAL/LAB on calcium mobilization; Tie2 Signaling; Signaling by FGFR2 in disease; Signaling by FGFR3 fusions in cancer; G beta:gamma signalling through PI3Kgamma; Interleukin-7 signaling; Downstream signal transduction; GP1b-IX-V activation signalling; Signaling by FGFR3 point mutants in cancer; PI3K/AKT activation; Nephrin family interactions; Constitutive Signaling by Aberrant PI3K in Cancer; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Gastrin-CREB signalling pathway via PKC and MAPK; Signaling by SCF-KIT; GAB1 signalosome",229,High,1
O94830,Phospholipase DDHD2 OS=Homo sapiens OX=9606 GN=DDHD2 PE=1 SV=2,0,47.94,19,9,48,9,711,81,5.39,17183,,9,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;Golgi;membrane,catalytic activity;metal ion binding;protein binding,"Pf00536, Pf02825, Pf02862",23259,ENSG00000085788.13,DDHD2,8,,,Synthesis of PA,5,High,1
Q6ZNW5,GDP-D-glucose phosphorylase 1 OS=Homo sapiens OX=9606 GN=GDPGP1 PE=1 SV=2,0,47.929,30,7,38,7,385,42.3,6.47,19422,2.22,6,1,metabolic process,cytoplasm,catalytic activity;nucleotide binding,,390637,ENSG00000183208.12,GDPGP1,15,,,,0,High,1
Q8TE77,Protein phosphatase Slingshot homolog 3 OS=Homo sapiens OX=9606 GN=SSH3 PE=1 SV=2,0,47.895,20,10,37,10,659,73,5.3,15646,,10,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytoskeleton;nucleus,catalytic activity;DNA binding;protein binding,"Pf00782, Pf08766",54961,ENSG00000172830.12,SSH3,11,Regulation of actin cytoskeleton; Axon guidance,Regulation of Actin Cytoskeleton,,3,High,1
Q99766,"ATP synthase subunit s, mitochondrial OS=Homo sapiens OX=9606 GN=DMAC2L PE=1 SV=3",0,47.888,27,6,93,6,215,24.9,7.56,41585,0,6,1,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion,metal ion binding;transporter activity,,27109,ENSG00000125375.14,ATP5S,14,,Electron Transport Chain; Oxidative phosphorylation,Cristae formation; Formation of ATP by chemiosmotic coupling,9,High,1
O14521,"Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial OS=Homo sapiens OX=9606 GN=SDHD PE=1 SV=1",0,47.88,11,5,389,5,159,17,8.63,190406,,5,,metabolic process;transport,membrane;mitochondrion,catalytic activity;metal ion binding,Pf05328,6392,ENSG00000204370.9,SDHD,11,Carbon metabolism; Non-alcoholic fatty liver disease (NAFLD); Parkinson's disease; Citrate cycle (TCA cycle); Metabolic pathways; Alzheimer's disease; Oxidative phosphorylation; Huntington's disease,Electron Transport Chain; Amino Acid metabolism; TCA Cycle,Respiratory electron transport; Citric acid cycle (TCA cycle),17,High,1
Q96SU4,Oxysterol-binding protein-related protein 9 OS=Homo sapiens OX=9606 GN=OSBPL9 PE=1 SV=2,0,47.87,14,9,37,9,736,83.1,6.18,19188,,9,,metabolic process;transport,cytosol;endosome;Golgi;membrane,transporter activity,"Pf00169, Pf01237, Pf15409, Pf15413",114883,ENSG00000117859.18,OSBPL9,1,,,Synthesis of bile acids and bile salts,5,High,1
Q9ULP9,TBC1 domain family member 24 OS=Homo sapiens OX=9606 GN=TBC1D24 PE=1 SV=2,0,47.841,15,9,53,9,559,62.9,7.36,20410,2.44,8,1,cell organization and biogenesis;regulation of biological process,cytoplasm;membrane,enzyme regulator activity;protein binding,"Pf00566, Pf07534",57465,ENSG00000162065.12,TBC1D24,16,,,TBC/RABGAPs,4,High,1
Q5TAQ9,DDB1- and CUL4-associated factor 8 OS=Homo sapiens OX=9606 GN=DCAF8 PE=1 SV=1,0,47.839,16,7,58,7,597,66.8,5.39,24603,0,6,1,metabolic process,cytoplasm;cytosol;mitochondrion;nucleus,protein binding,Pf00400,50717,ENSG00000132716.18,DCAF8,1,,,Neddylation,3,High,1
O14910,Protein lin-7 homolog A OS=Homo sapiens OX=9606 GN=LIN7A PE=1 SV=2,0,47.818,24,4,50,2,233,26,8.72,27247,,4,,cell organization and biogenesis;transport,membrane,protein binding,"Pf00595, Pf02828",8825,ENSG00000111052.7,LIN7A,12,,,Dopamine Neurotransmitter Release Cycle; Neurexins and neuroligins,6,High,1
Q8IZL8,"Proline-, glutamic acid- and leucine-rich protein 1 OS=Homo sapiens OX=9606 GN=PELP1 PE=1 SV=2",0,47.808,13,9,40,9,1130,119.6,4.34,16130,0,9,1,metabolic process;regulation of biological process;response to stimulus,cytoplasm;membrane;nucleus,protein binding;RNA binding,"Pf08166, Pf08167",27043,ENSG00000141456.14,PELP1,17,,,Major pathway of rRNA processing in the nucleolus and cytosol; PTK6 Expression,8,High,1
Q2TAY7,WD40 repeat-containing protein SMU1 OS=Homo sapiens OX=9606 GN=SMU1 PE=1 SV=2,0,47.692,20,8,33,8,513,57.5,7.18,17989,,8,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;nucleus;spliceosomal complex,protein binding,Pf00400,55234,ENSG00000122692.8,SMU1,9,,,,0,High,1
Q16816,"Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform OS=Homo sapiens OX=9606 GN=PHKG1 PE=2 SV=3",0,47.654,24,7,66,6,387,45,6.86,20193,59.63,3,4,metabolic process;regulation of biological process;response to stimulus,cytosol;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf06293, Pf07714, Pf14531",5260,ENSG00000164776.9,PHKG1,7,Calcium signaling pathway; Glucagon signaling pathway; Insulin signaling pathway,Glycogen Metabolism,Glycogen breakdown (glycogenolysis),8,High,1
Q7Z739,YTH domain-containing family protein 3 OS=Homo sapiens OX=9606 GN=YTHDF3 PE=1 SV=1,0,47.631,21,9,39,6,585,63.8,9.04,16669,,9,,regulation of biological process,cytoplasm;cytosol,protein binding;RNA binding,Pf04146,253943,ENSG00000185728.16,YTHDF3,8,,,,0,High,1
Q11201,"CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 OS=Homo sapiens OX=9606 GN=ST3GAL1 PE=2 SV=1",0,47.549,34,9,33,9,340,39.1,9.09,13314,,9,,metabolic process,extracellular;Golgi;membrane,catalytic activity,Pf00777,6482,ENSG00000008513.14,ST3GAL1,8,Metabolic pathways; Glycosaminoglycan biosynthesis - keratan sulfate; Mucin type O-glycan biosynthesis; Glycosphingolipid biosynthesis - globo and isoglobo series; Glycosphingolipid biosynthesis - ganglio series,Ganglio Sphingolipid Metabolism; Globo Sphingolipid Metabolism,Keratan sulfate biosynthesis; Termination of O-glycan biosynthesis; Sialic acid metabolism,21,High,1
Q8WWC4,"m-AAA protease-interacting protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=MAIP1 PE=1 SV=1",0,47.486,24,6,107,6,291,32.5,9.17,56294,,6,,cell organization and biogenesis;cellular homeostasis;transport,membrane;mitochondrion;organelle lumen,protein binding,,79568,ENSG00000162972.10,C2orf47; MAIP1,2,,,Processing of SMDT1,3,High,1
P46736,Lys-63-specific deubiquitinase BRCC36 OS=Homo sapiens OX=9606 GN=BRCC3 PE=1 SV=2,0,47.481,24,6,88,5,316,36,5.92,31075,0,6,1,cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;nucleus,catalytic activity;enzyme regulator activity;metal ion binding;protein binding,Pf01398,79184,ENSG00000185515.14,BRCC3,X,NOD-like receptor signaling pathway; Homologous recombination,,G2/M DNA damage checkpoint; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; Nonhomologous End-Joining (NHEJ); Metalloprotease DUBs,18,High,1
A0A0J9YX35,Immunoglobulin heavy variable 3-64D OS=Homo sapiens OX=9606 GN=IGHV3-64D PE=3 SV=1,0,47.475,32,5,77,1,117,12.8,7.85,42071,5.47,4,1,response to stimulus,extracellular;membrane,catalytic activity,"Pf03492, Pf07686",102723170,ENSG00000282639.1; ENSG00000282644.1,IGHV3-64D,14; CHR_HSCHR14_3_CTG1,,,,0,High,1
O43325,LYR motif-containing protein 1 OS=Homo sapiens OX=9606 GN=LYRM1 PE=2 SV=1,0,47.425,52,7,108,7,122,14.3,9.94,47451,,7,,,mitochondrion;nucleus,,"Pf05347, Pf13232",57149,ENSG00000102897.9,LYRM1,16,,,,0,High,1
Q14257,Reticulocalbin-2 OS=Homo sapiens OX=9606 GN=RCN2 PE=1 SV=1,0,47.373,32,7,29,7,317,36.9,4.4,11035,,7,,,endoplasmic reticulum;organelle lumen,metal ion binding;protein binding,Pf13499,5955,ENSG00000117906.13,RCN2,15,,,,0,High,1
P80748,Immunoglobulin lambda variable 3-21 OS=Homo sapiens OX=9606 GN=IGLV3-21 PE=1 SV=2,0,47.363,48,6,56,6,117,12.4,5.29,30614,0,6,1,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity,"Pf00047, Pf07679, Pf07686",28796,ENSG00000211662.2,IGLV3-21,22,,,FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis,26,High,1
P02652,Apolipoprotein A-II OS=Homo sapiens OX=9606 GN=APOA2 PE=1 SV=1,0,47.326,64,8,131,8,100,11.2,6.62,57052,2.16,7,2,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;endosome;extracellular;organelle lumen,enzyme regulator activity;protein binding;transporter activity,Pf04711,336,ENSG00000158874.11,APOA2,1,PPAR signaling pathway,PPAR Alpha Pathway; PPAR signaling pathway; Statin Pathway,Signaling by GPCR; Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Retinoid metabolism and transport; Chylomicron assembly; Chylomicron remodeling; PPARA activates gene expression,24,High,1
Q9Y3D3,"28S ribosomal protein S16, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS16 PE=1 SV=1",0,47.29,34,4,82,4,137,15.3,9.5,37998,4.31,4,1,cell organization and biogenesis;metabolic process,cytosol;membrane;mitochondrion;ribosome,protein binding;structural molecule activity,Pf00886,51021,ENSG00000182180.13,MRPS16,10,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
P55957,BH3-interacting domain death agonist OS=Homo sapiens OX=9606 GN=BID PE=1 SV=1,0,47.247,42,5,31,5,195,22,5.44,16469,,5,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;mitochondrion,protein binding,Pf06393,637,ENSG00000015475.18,BID,22,Apoptosis; Pathways in cancer; Amyotrophic lateral sclerosis (ALS); p53 signaling pathway; Tuberculosis; Natural killer cell mediated cytotoxicity; Viral myocarditis; Non-alcoholic fatty liver disease (NAFLD); Platinum drug resistance; Sphingolipid signaling pathway; Alzheimer's disease; Apoptosis - multiple species,miRNA Regulation of DNA Damage Response; TP53 Network; Alzheimers Disease; TNF alpha Signaling Pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Photodynamic therapy-induced HIF-1 survival signaling; Apoptosis Modulation by HSP70; Regulation of Apoptosis by Parathyroid Hormone-related Protein; DNA Damage Response,"Activation, translocation and oligomerization of BAX; Activation, myristolyation of BID and translocation to mitochondria; Activation of BAD and translocation to mitochondria ; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; Activation and oligomerization of BAK protein; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members",38,High,1
O14807,Ras-related protein M-Ras OS=Homo sapiens OX=9606 GN=MRAS PE=1 SV=2,0,47.218,47,10,63,10,208,23.8,8.79,26907,,10,,cell organization and biogenesis;development;regulation of biological process;response to stimulus,membrane,catalytic activity;nucleotide binding;protein binding,"Pf00009, Pf00071, Pf08477",22808,ENSG00000158186.12,MRAS,3,Proteoglycans in cancer; Rap1 signaling pathway; Ras signaling pathway; HTLV-I infection; Phospholipase D signaling pathway; Regulation of actin cytoskeleton; MAPK signaling pathway; Tight junction,MAPK Signaling Pathway; Regulation of Actin Cytoskeleton,,10,High,1
Q8IXL7-2,Isoform 2 of Methionine-R-sulfoxide reductase B3 OS=Homo sapiens OX=9606 GN=MSRB3,0,47.204,46,7,54,7,185,20,7.15,13763,47.02,6,1,metabolic process;response to stimulus,cytosol;endoplasmic reticulum;mitochondrion,catalytic activity;metal ion binding;protein binding,Pf01641,253827,ENSG00000174099.10,MSRB3,12,,Sulindac Metabolic Pathway,,1,High,1
O75477,Erlin-1 OS=Homo sapiens OX=9606 GN=ERLIN1 PE=1 SV=2,0,47.203,27,7,47,5,348,39.1,7.87,22183,,7,,,,,,,,,,,,,0,High,1
Q02108,Guanylate cyclase soluble subunit alpha-1 OS=Homo sapiens OX=9606 GN=GUCY1A1 PE=1 SV=2,0,47.153,19,10,46,10,690,77.4,7.11,17870,2.19,9,2,metabolic process;regulation of biological process;response to stimulus,cytoplasm;membrane,catalytic activity;nucleotide binding;protein binding;receptor activity,"Pf00211, Pf07700, Pf07701",2982,ENSG00000164116.16,GUCY1A3,4,Oxytocin signaling pathway; Vascular smooth muscle contraction; Long-term depression; Renin secretion; Platelet activation; Circadian entrainment; Purine metabolism; cGMP-PKG signaling pathway; Salivary secretion; Gap junction,Myometrial Relaxation and Contraction Pathways,Nitric oxide stimulates guanylate cyclase,14,High,1
Q92888,Rho guanine nucleotide exchange factor 1 OS=Homo sapiens OX=9606 GN=ARHGEF1 PE=1 SV=2,0,47.131,15,11,69,11,912,102.4,5.66,28434,0,11,1,cell proliferation;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,enzyme regulator activity;protein binding;RNA binding,"Pf00621, Pf09128",9138,ENSG00000076928.17,ARHGEF1,19,Pathways in cancer; Proteoglycans in cancer; Platelet activation; Regulation of actin cytoskeleton; Vascular smooth muscle contraction,G Protein Signaling Pathways; EGF/EGFR Signaling Pathway; Regulation of Actin Cytoskeleton; G13 Signaling Pathway,G alpha (12/13) signalling events; NRAGE signals death through JNK; Signalling by NGF; Rho GTPase cycle,20,High,1
Q9HCJ6,Synaptic vesicle membrane protein VAT-1 homolog-like OS=Homo sapiens OX=9606 GN=VAT1L PE=1 SV=2,0,47.124,31,9,73,9,419,45.9,5.06,30719,,9,,metabolic process,,catalytic activity;metal ion binding;protein binding,"Pf00107, Pf08240, Pf13602",57687,ENSG00000171724.2,VAT1L,16,,,,0,High,1
Q9NWH9,SAFB-like transcription modulator OS=Homo sapiens OX=9606 GN=SLTM PE=1 SV=2,0,47.097,12,10,70,10,1034,117.1,7.87,27057,0,10,1,cell death;metabolic process;regulation of biological process,nucleus,DNA binding;RNA binding,"Pf00076, Pf02037, Pf13893, Pf14259",79811,ENSG00000137776.16,SLTM,15,,,,0,High,1
Q8NEZ2,Vacuolar protein sorting-associated protein 37A OS=Homo sapiens OX=9606 GN=VPS37A PE=1 SV=1,0,47.068,36,9,35,9,397,44.3,5.57,14630,2.53,9,1,cell communication;cell organization and biogenesis;metabolic process;response to stimulus;transport,cytosol;endosome;membrane;nucleus,protein binding,Pf07200,137492,ENSG00000155975.9,VPS37A,8,Endocytosis,,Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); Membrane binding and targetting of GAG proteins,13,High,1
Q14249,"Endonuclease G, mitochondrial OS=Homo sapiens OX=9606 GN=ENDOG PE=1 SV=4",0,47.041,31,6,56,6,297,32.6,9.5,27040,,6,,cell death;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cytosol;mitochondrion;nucleus,catalytic activity;metal ion binding;protein binding,Pf01223,2021,ENSG00000167136.6,ENDOG,9,Apoptosis,Nanomaterial induced apoptosis,,2,High,1
Q2M2I5,"Keratin, type I cytoskeletal 24 OS=Homo sapiens OX=9606 GN=KRT24 PE=1 SV=1",0,47.005,10,5,190,1,525,55.1,4.96,105476,0,5,2,cell death;transport,cytosol;membrane,structural molecule activity;transporter activity,"Pf00529, Pf02321, Pf13437, Pf13533",192666,ENSG00000167916.4,KRT24,17,,,Formation of the cornified envelope,3,High,1
Q96PE3,Inositol polyphosphate-4-phosphatase type I A OS=Homo sapiens OX=9606 GN=INPP4A PE=1 SV=1,0,46.967,11,7,39,7,977,109.9,6.96,16765,,7,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,catalytic activity;protein binding,Pf00168,3631,ENSG00000040933.15,INPP4A,2,Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system,Insulin Signaling,"Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of IP2, IP, and Ins in the cytosol",12,High,1
P51798,H(+)/Cl(-) exchange transporter 7 OS=Homo sapiens OX=9606 GN=CLCN7 PE=1 SV=2,0,46.892,16,9,43,9,805,88.6,8.43,18640,,9,,response to stimulus;transport,membrane;vacuole,nucleotide binding;transporter activity,"Pf00571, Pf00654",1186,ENSG00000103249.17,CLCN7,16,,,Stimuli-sensing channels,3,High,1
Q9BYB0,SH3 and multiple ankyrin repeat domains protein 3 OS=Homo sapiens OX=9606 GN=SHANK3 PE=1 SV=3,0,46.863,9,11,32,11,1731,184.6,8.88,13679,,11,,cell differentiation;cell organization and biogenesis;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,metal ion binding;protein binding;structural molecule activity,"Pf00018, Pf00023, Pf00536, Pf07647, Pf07653, Pf12796, Pf13637, Pf13857, Pf14604",85358,ENSG00000283243.1,SHANK3,22; CHR_HG1311_PATCH,Glutamatergic synapse,,RET signaling; Neurexins and neuroligins,7,High,1
Q86X10,Ral GTPase-activating protein subunit beta OS=Homo sapiens OX=9606 GN=RALGAPB PE=1 SV=1,0,46.85,8,9,33,9,1494,166.7,6.79,14863,,9,,regulation of biological process,,enzyme regulator activity;protein binding,Pf02145,57148,ENSG00000170471.14,RALGAPB,20,,,Translocation of GLUT4 to the plasma membrane,3,High,1
Q53EL6,Programmed cell death protein 4 OS=Homo sapiens OX=9606 GN=PDCD4 PE=1 SV=2,0,46.839,27,10,31,10,469,51.7,5.21,12295,,10,,cell death;cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,protein binding;RNA binding,Pf02847,27250,ENSG00000150593.17,PDCD4,10,MicroRNAs in cancer; Proteoglycans in cancer,Interferon type I signaling pathways,Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Interleukin-12 family signaling,8,High,1
Q96B77,Transmembrane protein 186 OS=Homo sapiens OX=9606 GN=TMEM186 PE=2 SV=1,0,46.829,24,6,85,6,213,24.9,9.86,37211,,6,,,membrane;mitochondrion,,,25880,ENSG00000184857.7,TMEM186,16,,,,0,High,1
Q9UHA4,Ragulator complex protein LAMTOR3 OS=Homo sapiens OX=9606 GN=LAMTOR3 PE=1 SV=1,0,46.82,49,4,91,4,124,13.6,7.34,39315,0,4,1,metabolic process;regulation of biological process;response to stimulus;transport,endosome;membrane,enzyme regulator activity;protein binding;structural molecule activity,Pf08923,8649,ENSG00000109270.12,LAMTOR3,4,mTOR signaling pathway; MAPK signaling pathway,MAPK Signaling Pathway,Energy dependent regulation of mTOR by LKB1-AMPK; Neutrophil degranulation; MAP2K and MAPK activation; Regulation of PTEN gene transcription; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Macroautophagy; Interleukin-20 family signaling,28,High,1
Q9BUT1,3-hydroxybutyrate dehydrogenase type 2 OS=Homo sapiens OX=9606 GN=BDH2 PE=1 SV=2,0,46.788,37,8,99,8,245,26.7,7.65,43077,0,8,2,cell differentiation;metabolic process,cytoplasm;cytosol;mitochondrion,catalytic activity;nucleotide binding,"Pf00106, Pf13561",56898,ENSG00000164039.14,BDH2,4,Metabolic pathways; Butanoate metabolism; Synthesis and degradation of ketone bodies,,Synthesis of Ketone Bodies,7,High,1
Q8N1F8,Serine/threonine-protein kinase 11-interacting protein OS=Homo sapiens OX=9606 GN=STK11IP PE=1 SV=4,0,46.782,12,9,31,9,1088,120.2,5.36,12546,,9,,,,,,,,,,,,,0,High,1
A0A0C4DH73,Immunoglobulin kappa variable 1-12 OS=Homo sapiens OX=9606 GN=IGKV1-12 PE=3 SV=1,0,46.762,42,7,50,1,117,12.6,8.31,25218,,7,,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity,"Pf00047, Pf07679, Pf07686, Pf13927",28940; 28903,ENSG00000282694.3; ENSG00000243290.3,IGKV1-12; IGKV1D-12,2; CHR_HG2290_PATCH,,,FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis,26,High,1
Q6P4A7,Sideroflexin-4 OS=Homo sapiens OX=9606 GN=SFXN4 PE=1 SV=1,0,46.632,18,5,112,5,337,38,9.19,52457,,5,,transport,membrane;mitochondrion,transporter activity,Pf03820,119559,ENSG00000183605.16,SFXN4,10,,,,0,High,1
Q12846,Syntaxin-4 OS=Homo sapiens OX=9606 GN=STX4 PE=1 SV=2,0,46.599,32,8,34,8,297,34.2,6.28,15971,,8,,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;cytosol;endosome;membrane;vacuole,enzyme regulator activity;protein binding,"Pf00804, Pf05739",6810,ENSG00000103496.14,STX4,16,SNARE interactions in vesicular transport; Vasopressin-regulated water reabsorption,Insulin Signaling,Translocation of GLUT4 to the plasma membrane; Clathrin derived vesicle budding; Disinhibition of SNARE formation; ER-Phagosome pathway; Other interleukin signaling,20,High,1
Q86UX7,Fermitin family homolog 3 OS=Homo sapiens OX=9606 GN=FERMT3 PE=1 SV=1,0,46.518,19,9,33,9,667,75.9,6.98,13005,,9,,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,extracellular;membrane;organelle lumen,protein binding,"Pf00169, Pf00373",83706,ENSG00000149781.12,FERMT3,11,Platelet activation,,Platelet degranulation,5,High,1
Q05084,Islet cell autoantigen 1 OS=Homo sapiens OX=9606 GN=ICA1 PE=1 SV=2,0,46.501,26,9,40,9,483,54.6,5.81,16669,,9,,regulation of biological process;transport,cytoplasm;cytosol;Golgi;membrane,protein binding,"Pf04629, Pf06456",3382,ENSG00000003147.17,ICA1,7,Type I diabetes mellitus,,,1,High,1
P78356,Phosphatidylinositol 5-phosphate 4-kinase type-2 beta OS=Homo sapiens OX=9606 GN=PIP4K2B PE=1 SV=1,0,46.476,20,6,32,4,416,47.3,7.33,15728,,6,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;vacuole,catalytic activity;nucleotide binding;protein binding;signal transducer activity,Pf01504,8396,ENSG00000276293.4; ENSG00000277292.2,PIP4K2B,17; CHR_HSCHR17_7_CTG4,Inositol phosphate metabolism; Regulation of actin cytoskeleton; Phosphatidylinositol signaling system,Regulation of Actin Cytoskeleton,"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs at the plasma membrane; Synthesis of PIPs in the nucleus",22,High,1
O60551,Glycylpeptide N-tetradecanoyltransferase 2 OS=Homo sapiens OX=9606 GN=NMT2 PE=1 SV=1,0,46.389,21,8,60,4,498,56.9,7.58,21127,,8,,metabolic process;regulation of biological process;transport,cytoplasm;cytosol;Golgi;membrane,catalytic activity,"Pf01233, Pf02799",9397,ENSG00000152465.17,NMT2,10,,,"Signaling by GPCR; Inactivation, recovery and regulation of the phototransduction cascade; Membrane binding and targetting of GAG proteins",13,High,1
Q15018,BRISC complex subunit Abraxas 2 OS=Homo sapiens OX=9606 GN=ABRAXAS2 PE=1 SV=2,0,46.328,26,9,46,9,415,46.9,6.21,18481,,9,,cell division;cell organization and biogenesis;metabolic process;response to stimulus,cytoplasm;cytoskeleton;cytosol;nucleus,protein binding,Pf00261,23172,ENSG00000165660.7,FAM175B; ABRAXAS2,10,,,Metalloprotease DUBs,4,High,1
Q29974,"HLA class II histocompatibility antigen, DRB1-16 beta chain OS=Homo sapiens OX=9606 GN=HLA-DRB1 PE=1 SV=1",0,46.318,22,5,49,5,266,30,7.74,20656,0,5,1,cell organization and biogenesis;defense response;regulation of biological process;response to stimulus,cell surface;endoplasmic reticulum;endosome;Golgi;membrane;vacuole,protein binding;receptor activity;signal transducer activity,"Pf00969, Pf07654",3123,,HLA-DRB1,6,,Allograft Rejection; Cytokines and Inflammatory Response,PD-1 signaling; Translocation of ZAP-70 to Immunological synapse; MHC class II antigen presentation; Downstream TCR signaling; Generation of second messenger molecules; Interferon gamma signaling; Phosphorylation of CD3 and TCR zeta chains,15,High,1
Q96C11,FGGY carbohydrate kinase domain-containing protein OS=Homo sapiens OX=9606 GN=FGGY PE=1 SV=2,0,46.315,24,9,26,9,551,60,6.35,10904,,9,,cellular homeostasis;metabolic process,,catalytic activity;enzyme regulator activity,"Pf00370, Pf02782",55277,ENSG00000172456.17,FGGY,1,,,,0,High,1
Q8NEY1,Neuron navigator 1 OS=Homo sapiens OX=9606 GN=NAV1 PE=1 SV=2,0,46.312,10,11,44,11,1877,202.3,8.07,12656,4.05,10,1,cell differentiation;cell organization and biogenesis;cellular component movement;development,cytoplasm;cytoskeleton,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00910, Pf02562, Pf12325, Pf13191, Pf13207, Pf13521",89796,ENSG00000134369.15,NAV1,1,,,,0,High,1
O75828,Carbonyl reductase [NADPH] 3 OS=Homo sapiens OX=9606 GN=CBR3 PE=1 SV=3,0,46.308,25,6,99,4,277,30.8,6.18,47658,,6,,metabolic process,cytoplasm;cytosol,catalytic activity;nucleotide binding;protein binding,"Pf00106, Pf08659, Pf13561",874,ENSG00000159231.5,CBR3,21,Metabolic pathways; Arachidonic acid metabolism; Metabolism of xenobiotics by cytochrome P450,NRF2 pathway,Phase I - Functionalization of compounds,7,High,1
Q96R05,Retinoid-binding protein 7 OS=Homo sapiens OX=9606 GN=RBP7 PE=1 SV=1,0,46.307,40,5,38,5,134,15.5,7.8,16371,,5,,transport,cytoplasm,protein binding;transporter activity,Pf00061,116362,ENSG00000162444.11,RBP7,1,,Vitamin A and Carotenoid Metabolism,,1,High,1
Q14232,Translation initiation factor eIF-2B subunit alpha OS=Homo sapiens OX=9606 GN=EIF2B1 PE=1 SV=1,0,46.292,35,10,57,10,305,33.7,7.33,20554,2.06,10,1,metabolic process;response to stimulus,cytoplasm;cytosol;membrane,protein binding;RNA binding,Pf01008,1967,ENSG00000111361.12,EIF2B1,12,RNA transport,Translation Factors,Recycling of eIF2:GDP,7,High,1
P84103,Serine/arginine-rich splicing factor 3 OS=Homo sapiens OX=9606 GN=SRSF3 PE=1 SV=1,0,46.284,37,6,93,5,164,19.3,11.65,51143,,6,,metabolic process;regulation of biological process;transport,cytoplasm;nucleus,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",6428,ENSG00000112081.16,SRSF3,6,Herpes simplex infection; Spliceosome,mRNA Processing,Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway,14,High,1
P61289,Proteasome activator complex subunit 3 OS=Homo sapiens OX=9606 GN=PSME3 PE=1 SV=1,0,46.27,35,8,56,8,254,29.5,5.95,22732,0,8,1,cell death;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus;proteasome,enzyme regulator activity;protein binding,"Pf02251, Pf02252",10197,ENSG00000131467.10,PSME3,17,Proteasome; Antigen processing and presentation; Hepatitis C,Proteasome Degradation,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,152,High,1
Q96JG6,Syndetin OS=Homo sapiens OX=9606 GN=VPS50 PE=1 SV=3,0,46.252,11,8,31,8,964,111.1,6.2,11755,0,8,1,transport,endosome;membrane,protein binding,"Pf10474, Pf10475",55610,ENSG00000004766.15,CCDC132; VPS50,7,,,,0,High,1
P15735,"Phosphorylase b kinase gamma catalytic chain, liver/testis isoform OS=Homo sapiens OX=9606 GN=PHKG2 PE=1 SV=1",0,46.247,22,7,49,6,406,46.4,6.38,21162,,7,,metabolic process;regulation of biological process;response to stimulus,cytosol,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf01633, Pf07714",5261,ENSG00000156873.15,PHKG2,16,Insulin signaling pathway; Calcium signaling pathway; Glucagon signaling pathway,Glycogen Metabolism,Glycogen breakdown (glycogenolysis),8,High,1
Q16773,Kynurenine--oxoglutarate transaminase 1 OS=Homo sapiens OX=9606 GN=KYAT1 PE=1 SV=1,0,46.235,26,8,49,8,422,47.8,6.47,19694,2.25,8,1,metabolic process,cytoplasm;cytosol,catalytic activity;protein binding,"Pf00155, Pf01041, Pf01053, Pf01212",883,ENSG00000171097.13,CCBL1; KYAT1,9,Selenocompound metabolism; Chemical carcinogenesis; Tryptophan metabolism; Metabolic pathways,,Amino acid synthesis and interconversion (transamination); Tryptophan catabolism; Phenylalanine and tyrosine catabolism,10,High,1
P01903,"HLA class II histocompatibility antigen, DR alpha chain OS=Homo sapiens OX=9606 GN=HLA-DRA PE=1 SV=1",0,46.217,21,4,64,4,254,28.6,5,26926,,4,,cell organization and biogenesis;regulation of biological process;response to stimulus,cell surface;endoplasmic reticulum;endosome;Golgi;membrane;vacuole,protein binding;receptor activity;signal transducer activity,"Pf00993, Pf07654",3122,ENSG00000226260.9; ENSG00000230726.9; ENSG00000206308.11; ENSG00000228987.9; ENSG00000234794.9,HLA-DRA,6; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1,Tuberculosis; Th1 and Th2 cell differentiation; Systemic lupus erythematosus; Epstein-Barr virus infection; Influenza A; HTLV-I infection; Inflammatory bowel disease (IBD); Herpes simplex infection; Leishmaniasis; Intestinal immune network for IgA production; Toxoplasmosis; Asthma; Viral myocarditis; Type I diabetes mellitus; Antigen processing and presentation; Phagosome; Hematopoietic cell lineage; Staphylococcus aureus infection; Cell adhesion molecules (CAMs); Rheumatoid arthritis; Autoimmune thyroid disease; Allograft rejection; Graft-versus-host disease,Allograft Rejection; Cytokines and Inflammatory Response,PD-1 signaling; Translocation of ZAP-70 to Immunological synapse; MHC class II antigen presentation; Downstream TCR signaling; Generation of second messenger molecules; Interferon gamma signaling; Phosphorylation of CD3 and TCR zeta chains,38,High,1
Q13330,Metastasis-associated protein MTA1 OS=Homo sapiens OX=9606 GN=MTA1 PE=1 SV=2,0,46.206,18,11,33,9,715,80.7,9.26,12527,,11,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;nucleus,catalytic activity;DNA binding;metal ion binding;protein binding,"Pf00249, Pf00320, Pf01426, Pf01448",9112,ENSG00000182979.17,MTA1,14,,,ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of PTEN gene transcription; SUMOylation of transcription factors; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation,20,High,1
Q9BZE9,Tether containing UBX domain for GLUT4 OS=Homo sapiens OX=9606 GN=ASPSCR1 PE=1 SV=1,0,46.204,28,10,39,10,553,60.1,6.64,15309,,10,,regulation of biological process;transport,cytoplasm;cytosol;membrane;nucleus,protein binding,"Pf00789, Pf11470",79058,ENSG00000169696.15,ASPSCR1,17,Transcriptional misregulation in cancer,,Translocation of GLUT4 to the plasma membrane,4,High,1
P61923,Coatomer subunit zeta-1 OS=Homo sapiens OX=9606 GN=COPZ1 PE=1 SV=1,0,46.142,33,5,48,5,177,20.2,4.81,22052,,5,,transport,cytoplasm;cytosol;Golgi;membrane,,Pf01217,22818,ENSG00000111481.9,COPZ1,12,,,COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport,11,High,1
P01593,Immunoglobulin kappa variable 1D-33 OS=Homo sapiens OX=9606 GN=IGKV1D-33 PE=1 SV=2,0,46.12,29,4,57,2,117,12.8,4.78,31449,,4,,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity;protein binding,"Pf00047, Pf07679, Pf07686, Pf13927",28896,ENSG00000282811.1; ENSG00000242076.2; ENSG00000239975.2,IGKV1D-33,2; CHR_HG2290_PATCH,,,FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis,26,High,1
Q9NQE9,Histidine triad nucleotide-binding protein 3 OS=Homo sapiens OX=9606 GN=HINT3 PE=1 SV=1,0,46.065,30,5,102,5,182,20.3,6.6,36928,,5,,,cytoplasm;nucleus,catalytic activity;nucleotide binding,"Pf01230, Pf11969",135114,ENSG00000111911.6,HINT3,6,,,,0,High,1
Q8N0U4,Protein FAM185A OS=Homo sapiens OX=9606 GN=FAM185A PE=2 SV=3,0,46.034,26,8,33,8,392,42.3,7.97,14052,,8,,metabolic process,cytoplasm;cytosol,catalytic activity;nucleotide binding,"Pf11734, Pf13345",222234,ENSG00000222011.8,FAM185A,7,,,,0,High,1
Q9BT30,"Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial OS=Homo sapiens OX=9606 GN=ALKBH7 PE=1 SV=1",0,46.009,42,6,58,6,221,24.5,7.11,27831,,6,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,mitochondrion;organelle lumen,catalytic activity;metal ion binding,Pf13532,84266,ENSG00000125652.7,ALKBH7,19,,,,0,High,1
Q9UEW8,STE20/SPS1-related proline-alanine-rich protein kinase OS=Homo sapiens OX=9606 GN=STK39 PE=1 SV=3,0,45.946,24,8,104,6,545,59.4,6.29,29593,,8,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf07714, Pf12202",27347,ENSG00000198648.10,STK39,2,,,,0,High,1
Q8IX12,Cell division cycle and apoptosis regulator protein 1 OS=Homo sapiens OX=9606 GN=CCAR1 PE=1 SV=2,0,45.928,14,11,41,11,1150,132.7,5.76,13903,0,11,1,cell death;metabolic process;regulation of biological process,cytoplasm,DNA binding;protein binding;RNA binding,"Pf02037, Pf14443, Pf14444",55749,ENSG00000060339.13,CCAR1,10,,,mRNA Splicing - Major Pathway,4,High,1
P35754,Glutaredoxin-1 OS=Homo sapiens OX=9606 GN=GLRX PE=1 SV=2,0,45.902,49,4,240,4,106,11.8,8.09,119607,,4,,cellular homeostasis;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;mitochondrion;nucleus,catalytic activity;protein binding,"Pf00462, Pf05768, Pf13098, Pf13417, Pf13462",2745,ENSG00000173221.13,GLRX,5,,One Carbon Metabolism,Interconversion of nucleotide di- and triphosphates,4,High,1
Q5THJ4,Vacuolar protein sorting-associated protein 13D OS=Homo sapiens OX=9606 GN=VPS13D PE=1 SV=2,0,45.851,3,11,45,11,4388,491.6,6.58,17833,,11,,,,protein binding,"Pf00627, Pf06650, Pf12624",55187,ENSG00000048707.13,VPS13D,1,,,,0,High,1
Q8NI22,Multiple coagulation factor deficiency protein 2 OS=Homo sapiens OX=9606 GN=MCFD2 PE=1 SV=1,0,45.829,64,4,41,4,146,16.4,4.63,14996,,4,,cell organization and biogenesis;metabolic process;transport,endoplasmic reticulum;Golgi;membrane,metal ion binding;protein binding,Pf13499,90411,ENSG00000180398.11,MCFD2,2,,,Cargo concentration in the ER; COPII (Coat Protein 2) Mediated Vesicle Transport,9,High,1
Q8N573,Oxidation resistance protein 1 OS=Homo sapiens OX=9606 GN=OXR1 PE=1 SV=2,0,45.807,15,8,23,8,874,97.9,5.47,11292,,8,,cell death;metabolic process;regulation of biological process;response to stimulus,mitochondrion,catalytic activity;protein binding,"Pf01476, Pf07534",55074,ENSG00000164830.18,OXR1,8,,,,0,High,1
P05452,Tetranectin OS=Homo sapiens OX=9606 GN=CLEC3B PE=1 SV=3,0,45.8,24,4,35,4,202,22.5,5.67,14813,,4,,regulation of biological process;response to stimulus;transport,cytoplasm;extracellular;organelle lumen,metal ion binding;protein binding,Pf00059,7123,ENSG00000163815.5,CLEC3B,3,,,Platelet degranulation,4,High,1
Q9UBB6,Neurochondrin OS=Homo sapiens OX=9606 GN=NCDN PE=1 SV=1,0,45.777,16,10,49,10,729,78.8,5.48,20619,0,10,1,cell organization and biogenesis;regulation of biological process,cytoplasm;cytosol;membrane;nucleus,protein binding,Pf05536,23154,ENSG00000020129.15,NCDN,1,,,,0,High,1
P56537,Eukaryotic translation initiation factor 6 OS=Homo sapiens OX=9606 GN=EIF6 PE=1 SV=1,0,45.729,27,4,49,4,245,26.6,4.68,21362,,4,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus,protein binding;RNA binding,Pf01912,3692,ENSG00000242372.6,EIF6,20,Ribosome biogenesis in eukaryotes,Translation Factors,,2,High,1
Q17R31,Putative deoxyribonuclease TATDN3 OS=Homo sapiens OX=9606 GN=TATDN3 PE=1 SV=1,0,45.68,36,8,76,8,274,30.3,7.15,31744,,8,,metabolic process,nucleus,catalytic activity;metal ion binding,Pf01026,128387,ENSG00000203705.10,TATDN3,1,,,,0,High,1
Q9BXR0,Queuine tRNA-ribosyltransferase catalytic subunit 1 OS=Homo sapiens OX=9606 GN=QTRT1 PE=1 SV=3,0,45.661,29,9,36,9,403,44,7.23,16763,,9,,metabolic process,cytoplasm;membrane;mitochondrion;nucleus,catalytic activity;metal ion binding;protein binding,Pf01702,81890,ENSG00000213339.8,QTRT1,19,,,tRNA modification in the nucleus and cytosol,3,High,1
Q9NS86,LanC-like protein 2 OS=Homo sapiens OX=9606 GN=LANCL2 PE=1 SV=1,0,45.658,25,8,49,8,450,50.8,7.43,20752,0,8,1,regulation of biological process,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,nucleotide binding;protein binding,Pf05147,55915,ENSG00000132434.9,LANCL2,7,,,,0,High,1
P62899,60S ribosomal protein L31 OS=Homo sapiens OX=9606 GN=RPL31 PE=1 SV=1,0,45.629,39,7,106,7,125,14.5,10.54,53573,2.07,7,1,cell organization and biogenesis;metabolic process;transport,cytosol;membrane;ribosome,protein binding;RNA binding;structural molecule activity,Pf01198,6160,ENSG00000071082.10,RPL31,2,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
Q9HAV0,Guanine nucleotide-binding protein subunit beta-4 OS=Homo sapiens OX=9606 GN=GNB4 PE=1 SV=3,0,45.54,16,5,148,3,340,37.5,6,66052,,5,,metabolic process;regulation of biological process;response to stimulus,cytosol;membrane,protein binding;signal transducer activity,Pf00400,59345,ENSG00000114450.9,GNB4,3,Ras signaling pathway; Morphine addiction; Dopaminergic synapse; Cholinergic synapse; GABAergic synapse; Glutamatergic synapse; Pathways in cancer; PI3K-Akt signaling pathway; Circadian entrainment; Chemokine signaling pathway; Serotonergic synapse; Alcoholism; Retrograde endocannabinoid signaling,Myometrial Relaxation and Contraction Pathways; Chemokine signaling pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Calcium Regulation in the Cardiac Cell,"G alpha (z) signalling events; G alpha (12/13) signalling events; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G alpha (s) signalling events; Glucagon-type ligand receptors; Ca2+ pathway; Thromboxane signalling through TP receptor; ADP signalling through P2Y purinoceptor 1; ADP signalling through P2Y purinoceptor 12; Adrenaline,noradrenaline inhibits insulin secretion; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Presynaptic function of Kainate receptors; G beta:gamma signalling through PLC beta; Vasopressin regulates renal water homeostasis via Aquaporins; Glucagon signaling in metabolic regulation; Thrombin signalling through proteinase activated receptors (PARs); Prostacyclin signalling through prostacyclin receptor; G-protein activation; Gastrin-CREB signalling pathway via PKC and MAPK",64,High,1
Q9P0I2,ER membrane protein complex subunit 3 OS=Homo sapiens OX=9606 GN=EMC3 PE=1 SV=3,0,45.511,30,6,73,6,261,29.9,6.81,29919,,6,,metabolic process,membrane,,Pf01956,55831,ENSG00000125037.12,EMC3,3,,,,0,High,1
Q9Y3C6,Peptidyl-prolyl cis-trans isomerase-like 1 OS=Homo sapiens OX=9606 GN=PPIL1 PE=1 SV=1,0,45.481,30,4,68,4,166,18.2,7.99,29790,0,4,1,metabolic process,spliceosomal complex,catalytic activity;protein binding,Pf00160,51645,ENSG00000137168.7,PPIL1,6,Spliceosome,,mRNA Splicing - Major Pathway,5,High,1
Q8IV08,Phospholipase D3 OS=Homo sapiens OX=9606 GN=PLD3 PE=1 SV=1,0,45.414,23,11,49,11,490,54.7,6.47,20669,,11,,metabolic process,endoplasmic reticulum;membrane,catalytic activity;protein binding,"Pf00614, Pf13091, Pf13918",23646,ENSG00000105223.19,PLD3,19,Ether lipid metabolism; Glycerophospholipid metabolism; Metabolic pathways,,Synthesis of PG; Role of phospholipids in phagocytosis,12,High,1
Q9H6Q4,Cytosolic iron-sulfur assembly component 3 OS=Homo sapiens OX=9606 GN=CIAO3 PE=1 SV=1,0,45.334,21,8,41,8,476,53,7.23,17522,0,8,1,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,,catalytic activity;metal ion binding,"Pf02256, Pf02906",64428,ENSG00000103245.13,NARFL,16,,,Cytosolic iron-sulfur cluster assembly,2,High,1
Q6IA86,Elongator complex protein 2 OS=Homo sapiens OX=9606 GN=ELP2 PE=1 SV=2,0,45.331,14,9,38,9,826,92.4,5.96,15905,,9,,metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,protein binding,Pf00400,55250,ENSG00000134759.13,ELP2,18,,,HATs acetylate histones,3,High,1
O95486,Protein transport protein Sec24A OS=Homo sapiens OX=9606 GN=SEC24A PE=1 SV=2,0,45.267,10,9,49,7,1093,119.7,7.66,20843,,9,,cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytosol;endoplasmic reticulum;membrane,metal ion binding;protein binding,"Pf00626, Pf04810, Pf04811, Pf04815, Pf08033",10802,ENSG00000113615.12,SEC24A,5,Protein processing in endoplasmic reticulum,Sterol Regulatory Element-Binding Proteins (SREBP) signalling,"Regulation of cholesterol biosynthesis by SREBP (SREBF); Cargo concentration in the ER; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; COPII (Coat Protein 2) Mediated Vesicle Transport; MHC class II antigen presentation",20,High,1
Q96JB2,Conserved oligomeric Golgi complex subunit 3 OS=Homo sapiens OX=9606 GN=COG3 PE=1 SV=3,0,45.227,15,10,38,10,828,94,5.57,13737,,10,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,Golgi;membrane,protein binding;transporter activity,Pf04136,83548,ENSG00000136152.14,COG3,13,,,COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network,11,High,1
Q13185,Chromobox protein homolog 3 OS=Homo sapiens OX=9606 GN=CBX3 PE=1 SV=4,0,45.178,23,5,53,4,183,20.8,5.33,24497,0,5,1,cell organization and biogenesis;metabolic process;regulation of biological process,chromosome;membrane;nucleus,protein binding,"Pf00385, Pf01393",11335; 90416,ENSG00000122565.18,CBX3; C15orf57; CCDC32,7; 15,,Exercise-induced Circadian Regulation,RNA Polymerase I Chain Elongation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Transcriptional Regulation by E2F6,10,High,1
P24158,Myeloblastin OS=Homo sapiens OX=9606 GN=PRTN3 PE=1 SV=3,0,45.169,24,6,64,6,256,27.8,8.35,31288,,6,,cell differentiation;cell organization and biogenesis;cellular component movement;coagulation;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;extracellular;membrane;organelle lumen,catalytic activity;protein binding,"Pf00089, Pf09342",5657,ENSG00000196415.9; ENSG00000277804.4,PRTN3,19; CHR_HSCHR19_5_CTG2,,,Antimicrobial peptides; Common Pathway of Fibrin Clot Formation; Neutrophil degranulation; Other interleukin signaling,10,High,1
Q14393,Growth arrest-specific protein 6 OS=Homo sapiens OX=9606 GN=GAS6 PE=1 SV=3,0,45.092,19,9,31,9,678,74.9,5.69,11551,,9,,,,,,,,,,,,,0,High,1
Q9Y5B9,FACT complex subunit SPT16 OS=Homo sapiens OX=9606 GN=SUPT16H PE=1 SV=1,0,45.064,10,10,26,10,1047,119.8,5.66,10115,,10,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;nucleus,protein binding;RNA binding,"Pf00557, Pf08512, Pf08644, Pf14826",11198,ENSG00000092201.9,SUPT16H,14,,,HIV elongation arrest and recovery; TP53 Regulates Transcription of DNA Repair Genes; Tat-mediated HIV elongation arrest and recovery; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; Pausing and recovery of HIV elongation; Pausing and recovery of Tat-mediated HIV elongation; Formation of HIV-1 elongation complex containing HIV-1 Tat,24,High,1
Q09161,Nuclear cap-binding protein subunit 1 OS=Homo sapiens OX=9606 GN=NCBP1 PE=1 SV=1,0,45.061,18,11,33,11,790,91.8,6.43,11624,0,11,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;mitochondrion;nucleus,protein binding;RNA binding,"Pf02854, Pf09088, Pf09090",4686,ENSG00000136937.12,NCBP1,9,Spliceosome; mRNA surveillance pathway; RNA transport,mRNA Processing,Signaling by FGFR2 IIIa TM; RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Formation of the HIV-1 Early Elongation Complex; SLBP independent Processing of Histone Pre-mRNAs; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Cleavage of Growing Transcript in the Termination Region ; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase II Pre-transcription Events; snRNP Assembly; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Transport of the SLBP independent Mature mRNA; mRNA 3'-end processing; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; mRNA Capping; Regulation of expression of SLITs and ROBOs; Processing of Intronless Pre-mRNAs; Transport of Mature mRNA derived from an Intron-Containing Transcript; Formation of the Early Elongation Complex,61,High,1
Q9BY43,Charged multivesicular body protein 4a OS=Homo sapiens OX=9606 GN=CHMP4A PE=1 SV=3,0,45.008,36,7,56,7,222,25.1,4.7,17876,1.72,7,1,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane;nucleus,protein binding,Pf03357,29082,ENSG00000254505.9,CHMP4A,14,Endocytosis,,Budding and maturation of HIV virion; Macroautophagy; Endosomal Sorting Complex Required For Transport (ESCRT),12,High,1
Q01449,"Myosin regulatory light chain 2, atrial isoform OS=Homo sapiens OX=9606 GN=MYL7 PE=1 SV=1",0,44.975,33,4,62,4,175,19.4,4.88,30600,0,4,3,,cytosol,metal ion binding;protein binding,"Pf13405, Pf13499, Pf13833",58498,ENSG00000106631.8,MYL7,7,Tight junction; Leukocyte transendothelial migration; Focal adhesion; Regulation of actin cytoskeleton,,Smooth Muscle Contraction,6,High,1
Q92882,Osteoclast-stimulating factor 1 OS=Homo sapiens OX=9606 GN=OSTF1 PE=1 SV=2,0,44.975,37,7,161,7,214,23.8,5.68,63630,,7,,regulation of biological process;response to stimulus;transport,cytoplasm;extracellular;organelle lumen,protein binding,"Pf00018, Pf00023, Pf07653, Pf12796, Pf13637, Pf13857, Pf14604",26578,ENSG00000134996.11,OSTF1,9,,,Neutrophil degranulation,3,High,1
Q15363,Transmembrane emp24 domain-containing protein 2 OS=Homo sapiens OX=9606 GN=TMED2 PE=1 SV=1,0,44.94,25,4,131,4,201,22.7,5.17,54034,1.79,4,1,cell organization and biogenesis;regulation of biological process;transport,endoplasmic reticulum;Golgi;membrane,protein binding,Pf01105,10959,ENSG00000086598.10,TMED2,12,,,COPI-dependent Golgi-to-ER retrograde traffic; Cargo concentration in the ER; Pre-NOTCH Processing in Golgi; COPII (Coat Protein 2) Mediated Vesicle Transport; COPI-mediated anterograde transport,17,High,1
O15533,Tapasin OS=Homo sapiens OX=9606 GN=TAPBP PE=1 SV=1,0,44.931,21,6,192,6,448,47.6,7.15,73222,0,6,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;membrane,catalytic activity;protein binding;transporter activity,Pf07654,6892,ENSG00000236490.9; ENSG00000112493.12; ENSG00000206281.11,TAPBP,6; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_QBL_CTG1,Antigen processing and presentation,,"ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC",7,High,1
Q6GMV3,Putative peptidyl-tRNA hydrolase PTRHD1 OS=Homo sapiens OX=9606 GN=PTRHD1 PE=1 SV=1,0,44.89,31,5,51,5,140,15.8,9.1,22677,,5,,,,catalytic activity,,391356,ENSG00000184924.5,PTRHD1,2,,,,0,High,1
Q9Y2G5,GDP-fucose protein O-fucosyltransferase 2 OS=Homo sapiens OX=9606 GN=POFUT2 PE=1 SV=3,0,44.889,20,8,48,8,429,49.9,6.6,19165,,8,,metabolic process;regulation of biological process,endoplasmic reticulum;Golgi;membrane,catalytic activity,Pf10250,23275,ENSG00000186866.16,POFUT2,21,Other types of O-glycan biosynthesis,,O-glycosylation of TSR domain-containing proteins,5,High,1
P26583,High mobility group protein B2 OS=Homo sapiens OX=9606 GN=HMGB2 PE=1 SV=2,0,44.867,18,3,124,3,209,24,7.81,62522,,3,,cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;extracellular;nucleus,DNA binding;protein binding;RNA binding,"Pf00505, Pf09011",3148,ENSG00000164104.11,HMGB2,4,,Retinoblastoma (RB) in Cancer; Ectoderm Differentiation,Activation of DNA fragmentation factor,7,High,1
Q6UWP7,Lysocardiolipin acyltransferase 1 OS=Homo sapiens OX=9606 GN=LCLAT1 PE=1 SV=1,0,44.845,17,6,65,6,414,48.9,8.62,30440,,6,,development;metabolic process,cytosol;endoplasmic reticulum;membrane,catalytic activity;protein binding,Pf01553,253558,ENSG00000172954.13,LCLAT1,2,Metabolic pathways; Glycerolipid metabolism; Glycerophospholipid metabolism,,Synthesis of PA; Acyl chain remodeling of CL,9,High,1
P45984,Mitogen-activated protein kinase 9 OS=Homo sapiens OX=9606 GN=MAPK9 PE=1 SV=2,0,44.836,20,11,124,8,424,48.1,5.63,55570,,11,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;mitochondrion;nucleus,catalytic activity;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf01636, Pf07714, Pf14531",5601,ENSG00000050748.17,MAPK9,5,Osteoclast differentiation; AGE-RAGE signaling pathway in diabetic complications; Hepatitis C; Th1 and Th2 cell differentiation; ErbB signaling pathway; Toll-like receptor signaling pathway; Neurotrophin signaling pathway; Choline metabolism in cancer; Influenza A; Pancreatic cancer; Toxoplasmosis; RIG-I-like receptor signaling pathway; TNF signaling pathway; Protein processing in endoplasmic reticulum; Fc epsilon RI signaling pathway; Dopaminergic synapse; Colorectal cancer; Non-alcoholic fatty liver disease (NAFLD); Shigellosis; Prolactin signaling pathway; Wnt signaling pathway; Epithelial cell signaling in Helicobacter pylori infection; Hepatitis B; Tuberculosis; Ras signaling pathway; Progesterone-mediated oocyte maturation; Salmonella infection; Insulin resistance; NOD-like receptor signaling pathway; Apoptosis - multiple species; Inflammatory mediator regulation of TRP channels; Epstein-Barr virus infection; Focal adhesion; cAMP signaling pathway; T cell receptor signaling pathway; Pathways in cancer; Herpes simplex infection; FoxO signaling pathway; Apoptosis; GnRH signaling pathway; Chagas disease (American trypanosomiasis); Type II diabetes mellitus; Sphingolipid signaling pathway; Insulin signaling pathway; Pertussis; Endocrine resistance; MAPK signaling pathway; Retrograde endocannabinoid signaling; Adipocytokine signaling pathway,Regulation of toll-like receptor signaling pathway; IL-1 signaling pathway; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway; Prolactin Signaling Pathway; B Cell Receptor Signaling Pathway; TNF alpha Signaling Pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; ATM Signaling Pathway; Structural Pathway of Interleukin 1 (IL-1); Focal Adhesion; Rac1/Pak1/p38/MMP-2 pathway; Wnt Signaling Pathway Netpath; TGF-beta Signaling Pathway; MAPK Signaling Pathway; T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection; RIG-I-like Receptor Signaling; Canonical and Non-Canonical TGF-B signaling; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; BMP Signaling Pathway in Eyelid Development; Wnt Signaling in Kidney Disease; Wnt Signaling Pathway and Pluripotency; Wnt Signaling Pathway; EGF/EGFR Signaling Pathway; Insulin Signaling; TGF-beta Receptor Signaling; T-Cell antigen Receptor (TCR)  Signaling Pathway; DNA Damage Response (only ATM dependent); Estrogen signaling pathway; Toll-like receptor signaling pathway,FCERI mediated MAPK activation; Activated TLR4 signalling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; Activation of the AP-1 family of transcription factors; Oxidative Stress Induced Senescence,115,High,1
Q9H330,Transmembrane protein 245 OS=Homo sapiens OX=9606 GN=TMEM245 PE=1 SV=3,0,44.825,9,6,61,6,879,97.3,8.91,28986,,6,,,,,,,,,,,,,0,High,1
Q8NC60,Nitric oxide-associated protein 1 OS=Homo sapiens OX=9606 GN=NOA1 PE=1 SV=2,0,44.775,15,7,31,7,698,78.4,8.66,13703,,7,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process,membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf01926, Pf02421, Pf03193",84273,ENSG00000084092.6,NOA1,4,,,,0,High,1
P11234,Ras-related protein Ral-B OS=Homo sapiens OX=9606 GN=RALB PE=1 SV=1,0,44.752,22,4,164,2,206,23.4,6.62,81810,1.85,4,2,cell communication;cell death;cell division;regulation of biological process;response to stimulus,membrane;vacuole,catalytic activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf08477",5899,ENSG00000144118.13,RALB,2,Ras signaling pathway; Phospholipase D signaling pathway; Rap1 signaling pathway; Pathways in cancer; Pancreatic cancer,EGF/EGFR Signaling Pathway,p38MAPK events,13,High,1
Q9Y606,tRNA pseudouridine synthase A OS=Homo sapiens OX=9606 GN=PUS1 PE=1 SV=3,0,44.736,23,8,58,8,427,47.4,8.41,25345,,8,,cell organization and biogenesis;metabolic process,mitochondrion;nucleus;organelle lumen,catalytic activity;RNA binding,Pf01416,80324,ENSG00000177192.13,PUS1,12,,,tRNA modification in the mitochondrion,3,High,1
P05109,Protein S100-A8 OS=Homo sapiens OX=9606 GN=S100A8 PE=1 SV=1,0,44.731,42,7,161,7,93,10.8,7.03,69237,0,7,1,cell death;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen,metal ion binding;protein binding,"Pf01023, Pf13499",6279,ENSG00000143546.9,S100A8,1,,,Neutrophil degranulation; Metal sequestration by antimicrobial proteins; Regulation of TLR by endogenous ligand,7,High,1
Q9UKP3,Integrin beta-1-binding protein 2 OS=Homo sapiens OX=9606 GN=ITGB1BP2 PE=1 SV=1,0,44.717,25,5,50,5,347,38.4,5.16,18110,23.81,4,3,regulation of biological process;response to stimulus,,metal ion binding;protein binding,"Pf04968, Pf04969",26548,ENSG00000147166.10,ITGB1BP2,X,,,,0,High,1
P42285,Exosome RNA helicase MTR4 OS=Homo sapiens OX=9606 GN=MTREX PE=1 SV=3,0,44.706,15,12,32,12,1042,117.7,6.52,11595,,12,,metabolic process,nucleus;spliceosomal complex,catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding,"Pf00270, Pf04851, Pf08148, Pf13234",23517,ENSG00000039123.15,SKIV2L2,5,RNA degradation,,Major pathway of rRNA processing in the nucleolus and cytosol; mRNA Splicing - Major Pathway,8,High,1
Q9Y296,Trafficking protein particle complex subunit 4 OS=Homo sapiens OX=9606 GN=TRAPPC4 PE=1 SV=1,0,44.667,42,8,55,8,219,24.3,6.21,22183,,8,,cell organization and biogenesis;transport,cytosol;endoplasmic reticulum;Golgi;membrane,protein binding,"Pf04099, Pf04628",51399,ENSG00000280495.4; ENSG00000196655.11,TRAPPC4,11; CHR_HG2217_PATCH,,,COPII (Coat Protein 2) Mediated Vesicle Transport; RAB GEFs exchange GTP for GDP on RABs; Syndecan interactions,13,High,1
Q66K14,TBC1 domain family member 9B OS=Homo sapiens OX=9606 GN=TBC1D9B PE=1 SV=3,0,44.64,9,11,45,8,1250,140.4,5.25,15947,,11,,regulation of biological process;transport,membrane,enzyme regulator activity;metal ion binding;protein binding,"Pf00566, Pf02893, Pf13499",23061,ENSG00000197226.12; ENSG00000284400.1,TBC1D9B,5; CHR_HG30_PATCH,,,,0,High,1
O43306,Adenylate cyclase type 6 OS=Homo sapiens OX=9606 GN=ADCY6 PE=1 SV=2,0,44.61,9,9,49,6,1168,130.5,8.22,21260,0,9,1,metabolic process;regulation of biological process;response to stimulus,membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00211, Pf06327",112,ENSG00000174233.11,ADCY6,12,Bile secretion; HTLV-I infection; Estrogen signaling pathway; Vascular smooth muscle contraction; Insulin secretion; Endocrine resistance; Oxytocin signaling pathway; Vasopressin-regulated water reabsorption; Renin secretion; Melanogenesis; Longevity regulating pathway; Ovarian steroidogenesis; Adrenergic signaling in cardiomyocytes; Chemokine signaling pathway; Morphine addiction; Salivary secretion; Rap1 signaling pathway; Retrograde endocannabinoid signaling; Phospholipase D signaling pathway; Thyroid hormone synthesis; Regulation of lipolysis in adipocytes; Circadian entrainment; Gastric acid secretion; Dilated cardiomyopathy; Taste transduction; cAMP signaling pathway; Progesterone-mediated oocyte maturation; Oocyte meiosis; Glutamatergic synapse; Gap junction; GnRH signaling pathway; Purine metabolism; Aldosterone synthesis and secretion; Platelet activation; Longevity regulating pathway - multiple species; Pathways in cancer; Inflammatory mediator regulation of TRP channels; cGMP-PKG signaling pathway; Pancreatic secretion; Cholinergic synapse; Endocrine and other factor-regulated calcium reabsorption; GABAergic synapse,Myometrial Relaxation and Contraction Pathways; G Protein Signaling Pathways; Chemokine signaling pathway; Calcium Regulation in the Cardiac Cell,"Adenylate cyclase activating pathway; G alpha (z) signalling events; G alpha (s) signalling events; Adrenaline,noradrenaline inhibits insulin secretion; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Hedgehog 'off' state; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation in glucagon signalling; PKA activation; Adenylate cyclase inhibitory pathway",83,High,1
P62995,Transformer-2 protein homolog beta OS=Homo sapiens OX=9606 GN=TRA2B PE=1 SV=1,0,44.602,23,6,46,6,288,33.6,11.25,20186,,6,,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,membrane;nucleus;spliceosomal complex,protein binding;RNA binding,"Pf00076, Pf08777, Pf13893, Pf14259",6434,ENSG00000136527.17,TRA2B,3,Spliceosome,mRNA Processing,mRNA Splicing - Major Pathway,6,High,1
Q5D862,Filaggrin-2 OS=Homo sapiens OX=9606 GN=FLG2 PE=1 SV=1,0,44.511,7,7,53,7,2391,247.9,8.31,24350,,7,,transport,cytoplasm;extracellular;nucleus,metal ion binding;structural molecule activity,,388698,ENSG00000143520.6,FLG2,1,,,Neutrophil degranulation,3,High,1
P04003,C4b-binding protein alpha chain OS=Homo sapiens OX=9606 GN=C4BPA PE=1 SV=2,0,44.465,18,8,61,8,597,67,7.3,24163,,8,,defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,protein binding;RNA binding,Pf00084,722,ENSG00000123838.10,C4BPA,1,Pertussis; Complement and coagulation cascades,,Regulation of Complement cascade,6,High,1
Q9NUP9,Protein lin-7 homolog C OS=Homo sapiens OX=9606 GN=LIN7C PE=1 SV=1,0,44.451,32,5,45,3,197,21.8,8.43,24471,,5,,cell organization and biogenesis;transport,cytoplasm;membrane,protein binding,"Pf00595, Pf02828, Pf09829",55327,ENSG00000148943.11,LIN7C,11,,,Dopamine Neurotransmitter Release Cycle; Neurexins and neuroligins,6,High,1
Q15052-2,Isoform 2 of Rho guanine nucleotide exchange factor 6 OS=Homo sapiens OX=9606 GN=ARHGEF6,0,44.442,15,10,55,6,622,70.7,6.55,21611,4.72,9,1,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytosol,enzyme regulator activity;protein binding,"Pf00018, Pf00169, Pf00621, Pf07653, Pf14604",9459,ENSG00000129675.15,ARHGEF6,X,,Regulation of Actin Cytoskeleton,,1,High,1
Q92643,GPI-anchor transamidase OS=Homo sapiens OX=9606 GN=PIGK PE=1 SV=2,0,44.43,24,8,48,8,395,45.2,6.16,20462,,8,,metabolic process,endoplasmic reticulum;membrane,catalytic activity;protein binding,Pf01650,10026,ENSG00000142892.14,PIGK,1,Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways,,Attachment of GPI anchor to uPAR,6,High,1
P49840,Glycogen synthase kinase-3 alpha OS=Homo sapiens OX=9606 GN=GSK3A PE=1 SV=2,0,44.423,17,7,63,5,483,50.9,8.75,25827,,7,,cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;mitochondrion,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf01636, Pf07714, Pf14531",2931,ENSG00000105723.11,GSK3A,19,Non-alcoholic fatty liver disease (NAFLD); Chemokine signaling pathway; Dopaminergic synapse,IL-5 Signaling Pathway; Sterol Regulatory Element-Binding Proteins (SREBP) signalling; Leptin signaling pathway; B Cell Receptor Signaling Pathway; T-Cell Receptor and Co-stimulatory Signaling; Wnt Signaling Pathway Netpath; Regulation of Apoptosis by Parathyroid Hormone-related Protein; Angiopoietin Like Protein 8 Regulatory Pathway; Insulin Signaling; Glycogen Metabolism,AKT phosphorylates targets in the cytosol; XBP1(S) activates chaperone genes; Constitutive Signaling by AKT1 E17K in Cancer,25,High,1
P84157-2,Isoform 2 of Matrix-remodeling-associated protein 7 OS=Homo sapiens OX=9606 GN=MXRA7,0,44.413,44,5,45,1,170,17.5,4.15,19000,33.09,4,1,,,,,439921,ENSG00000182534.13,MXRA7,17,,,,0,High,1
Q9Y5L4,Mitochondrial import inner membrane translocase subunit Tim13 OS=Homo sapiens OX=9606 GN=TIMM13 PE=1 SV=1,0,44.408,69,5,131,5,95,10.5,8.18,70409,2.45,4,1,cell organization and biogenesis;transport,membrane;mitochondrion,metal ion binding;transporter activity,Pf02953,26517,ENSG00000099800.7,TIMM13,19,,,Mitochondrial protein import; Metabolism of proteins,2,High,1
Q16186,Proteasomal ubiquitin receptor ADRM1 OS=Homo sapiens OX=9606 GN=ADRM1 PE=1 SV=2,0,44.406,12,5,69,5,407,42.1,5.07,36152,,5,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;nucleus;proteasome,enzyme regulator activity;protein binding,Pf04683,11047,ENSG00000130706.12,ADRM1,20,,,UCH proteinases; Ub-specific processing proteases,5,High,1
Q96RS6,NudC domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NUDCD1 PE=1 SV=2,0,44.397,26,10,63,10,583,66.7,5.11,24568,0,10,1,,cytoplasm;cytosol;nucleus,protein binding,Pf04969,84955,ENSG00000120526.10,NUDCD1,8,,,,0,High,1
Q8WU76,Sec1 family domain-containing protein 2 OS=Homo sapiens OX=9606 GN=SCFD2 PE=1 SV=2,0,44.379,23,10,58,10,684,75.1,6.68,23580,,10,,transport,,,Pf00995,152579,ENSG00000184178.15,SCFD2,4,,,,0,High,1
P36915,Guanine nucleotide-binding protein-like 1 OS=Homo sapiens OX=9606 GN=GNL1 PE=1 SV=2,0,44.342,16,9,49,9,607,68.6,5.8,18122,,9,,regulation of biological process;response to stimulus,nucleus,catalytic activity;nucleotide binding;structural molecule activity,"Pf01926, Pf02421",2794,ENSG00000235986.9; ENSG00000229470.9; ENSG00000204590.12; ENSG00000206492.11; ENSG00000232143.9; ENSG00000228581.9; ENSG00000226882.9,GNL1,6; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1,,,,0,High,1
P31944,Caspase-14 OS=Homo sapiens OX=9606 GN=CASP14 PE=1 SV=2,0,44.291,32,9,34,9,242,27.7,5.58,12665,0,9,1,cell death;cell differentiation;metabolic process,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,Pf00656,23581,ENSG00000105141.5,CASP14,19,,,Formation of the cornified envelope,3,High,1
P62314,Small nuclear ribonucleoprotein Sm D1 OS=Homo sapiens OX=9606 GN=SNRPD1 PE=1 SV=1,0,44.277,38,3,51,3,119,13.3,11.56,20378,,3,,cell organization and biogenesis;metabolic process;transport,cytoplasm;cytosol;nucleus;spliceosomal complex,protein binding;RNA binding,Pf01423,6632,ENSG00000167088.10,SNRPD1,18,Spliceosome; Systemic lupus erythematosus,mRNA Processing,snRNP Assembly; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway,10,High,1
Q96H20,Vacuolar-sorting protein SNF8 OS=Homo sapiens OX=9606 GN=SNF8 PE=1 SV=1,0,44.22,27,6,60,6,258,28.8,6.65,25929,,6,,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane;nucleus,protein binding,Pf04157,11267,ENSG00000159210.9,SNF8,17,Endocytosis,,Endosomal Sorting Complex Required For Transport (ESCRT),4,High,1
Q9UHY7,Enolase-phosphatase E1 OS=Homo sapiens OX=9606 GN=ENOPH1 PE=1 SV=1,0,44.21,23,4,71,4,261,28.9,4.78,41506,,4,,metabolic process,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding,Pf13419,58478,ENSG00000145293.15,ENOPH1,4,Metabolic pathways; Cysteine and methionine metabolism,,Methionine salvage pathway,7,High,1
Q6UW68,Transmembrane protein 205 OS=Homo sapiens OX=9606 GN=TMEM205 PE=1 SV=1,0,44.187,28,5,123,5,189,21.2,8.62,58081,0,5,1,,membrane,,Pf13664,374882,ENSG00000105518.13,TMEM205,19,,,,0,High,1
O15212,Prefoldin subunit 6 OS=Homo sapiens OX=9606 GN=PFDN6 PE=1 SV=1,0,44.163,43,5,84,5,129,14.6,8.88,37181,,5,,cell organization and biogenesis;metabolic process,cytoplasm,catalytic activity;protein binding,"Pf01920, Pf15499",10471,ENSG00000204220.11; ENSG00000237335.8; ENSG00000224782.8; ENSG00000235692.8; ENSG00000206283.10,PFDN6,6; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_QBL_CTG1,,,Prefoldin mediated transfer of substrate  to CCT/TriC,5,High,1
Q5TFE4,5'-nucleotidase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NT5DC1 PE=1 SV=1,0,44.16,30,9,47,9,455,51.8,6.35,17695,1.63,8,2,metabolic process,,catalytic activity;metal ion binding;receptor activity;signal transducer activity,Pf05761,221294,ENSG00000178425.13,NT5DC1,6,,,,0,High,1
Q14766,Latent-transforming growth factor beta-binding protein 1 OS=Homo sapiens OX=9606 GN=LTBP1 PE=1 SV=4,0,44.154,5,6,37,6,1721,186.7,5.96,15898,,6,,metabolic process;regulation of biological process;response to stimulus,cell surface;extracellular;membrane;organelle lumen,catalytic activity;metal ion binding;protein binding;receptor activity;signal transducer activity,"Pf00683, Pf06247, Pf07645, Pf12662, Pf12947",4052,ENSG00000049323.15,LTBP1,2,TGF-beta signaling pathway,Hypothesized Pathways in Pathogenesis of Cardiovascular Disease; TGF-beta Receptor Signaling,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Molecules associated with elastic fibres,10,High,1
Q9BUL8,Programmed cell death protein 10 OS=Homo sapiens OX=9606 GN=PDCD10 PE=1 SV=1,0,44.044,37,6,59,6,212,24.7,8.19,30383,,6,,cell death;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytosol;Golgi;membrane,protein binding,Pf06840,11235,ENSG00000114209.14,PDCD10,3,,,,0,High,1
Q96P16,Regulation of nuclear pre-mRNA domain-containing protein 1A OS=Homo sapiens OX=9606 GN=RPRD1A PE=1 SV=1,0,43.928,23,5,33,3,312,35.7,7.55,15539,,5,,metabolic process;regulation of biological process,,protein binding,Pf04818,55197,ENSG00000141425.17,RPRD1A,18,,,RNA polymerase II transcribes snRNA genes,3,High,1
Q03519,Antigen peptide transporter 2 OS=Homo sapiens OX=9606 GN=TAP2 PE=1 SV=1,0,43.924,15,9,67,7,686,75.6,8.02,27397,,9,,response to stimulus;transport,endoplasmic reticulum;membrane,catalytic activity;nucleotide binding;protein binding;transporter activity,"Pf00005, Pf00664, Pf13304, Pf13476, Pf13481, Pf13555",6891,ENSG00000204267.13; ENSG00000228582.9; ENSG00000206299.8; ENSG00000206235.8,TAP2,6; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_MANN_CTG1,ABC transporters; Primary immunodeficiency; Antigen processing and presentation; Phagosome; Herpes simplex infection,,"ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC",11,High,1
Q8N1B4,Vacuolar protein sorting-associated protein 52 homolog OS=Homo sapiens OX=9606 GN=VPS52 PE=1 SV=1,0,43.912,14,9,36,9,723,82.2,5.99,13142,0,9,1,cell differentiation;transport,cytosol;endosome;Golgi;membrane,protein binding,"Pf04129, Pf09763",6293,ENSG00000228425.9; ENSG00000236014.10; ENSG00000206286.11; ENSG00000225590.9; ENSG00000223501.8; ENSG00000224455.9,VPS52,6; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_MCF_CTG1,,,Retrograde transport at the Trans-Golgi-Network,4,High,1
Q96RQ1,Endoplasmic reticulum-Golgi intermediate compartment protein 2 OS=Homo sapiens OX=9606 GN=ERGIC2 PE=1 SV=2,0,43.887,26,7,46,7,377,42.5,6.77,22510,,7,,transport,cytoplasm;endoplasmic reticulum;Golgi;membrane;nucleus,protein binding,"Pf07970, Pf13850",51290,ENSG00000087502.17,ERGIC2,12,,,,0,High,1
Q9Y2Q0,Phospholipid-transporting ATPase IA OS=Homo sapiens OX=9606 GN=ATP8A1 PE=1 SV=1,0,43.875,9,8,29,8,1164,131.3,6.84,12314,,8,,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;Golgi;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding;transporter activity,"Pf00122, Pf13246",10396,ENSG00000124406.16,ATP8A1,4,,Peptide GPCRs,Neutrophil degranulation; Ion transport by P-type ATPases,7,High,1
P09661,U2 small nuclear ribonucleoprotein A' OS=Homo sapiens OX=9606 GN=SNRPA1 PE=1 SV=2,0,43.819,33,6,43,6,255,28.4,8.62,22788,,6,,metabolic process;regulation of biological process;response to stimulus,nucleus;spliceosomal complex,protein binding;RNA binding,"Pf12799, Pf13855, Pf14580",6627,ENSG00000131876.16,SNRPA1,15,Spliceosome,mRNA Processing,Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Interleukin-12 family signaling; mRNA Splicing - Major Pathway,11,High,1
Q99439,Calponin-2 OS=Homo sapiens OX=9606 GN=CNN2 PE=1 SV=4,0,43.815,24,6,49,4,309,33.7,7.33,20862,,6,,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoskeleton;extracellular;membrane;organelle lumen,protein binding,"Pf00307, Pf00402",1265,ENSG00000064666.14,CNN2,19,,Myometrial Relaxation and Contraction Pathways,Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Neutrophil degranulation; Interleukin-12 family signaling,8,High,1
Q9H3Z4,DnaJ homolog subfamily C member 5 OS=Homo sapiens OX=9606 GN=DNAJC5 PE=1 SV=1,0,43.748,32,5,31,5,198,22.1,5.07,13903,,5,,regulation of biological process;transport,membrane;mitochondrion,protein binding,Pf00226,80331,ENSG00000101152.10,DNAJC5,20,Protein processing in endoplasmic reticulum,,"Neutrophil degranulation; GABA synthesis, release, reuptake and degradation",8,High,1
P25685,DnaJ homolog subfamily B member 1 OS=Homo sapiens OX=9606 GN=DNAJB1 PE=1 SV=4,0,43.738,21,8,64,8,340,38,8.63,27187,0,8,1,cell communication;cell organization and biogenesis;cellular homeostasis;coagulation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;mitochondrion;nucleus,catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding,"Pf00226, Pf01556",3337,ENSG00000132002.7,DNAJB1,19,Influenza A; Protein processing in endoplasmic reticulum,NRF2 pathway,MAPK6/MAPK4 signaling; Attenuation phase; HSP90 chaperone cycle for steroid hormone receptors (SHR); Regulation of HSF1-mediated heat shock response,13,High,1
Q8NFH3,Nucleoporin Nup43 OS=Homo sapiens OX=9606 GN=NUP43 PE=1 SV=1,0,43.671,21,4,29,4,380,42.1,5.63,11735,,4,,cell division;cell organization and biogenesis;metabolic process;regulation of biological process;transport,chromosome;cytosol;nucleus,protein binding,Pf00400,348995,ENSG00000120253.13,NUP43,6,RNA transport,,Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; Separation of Sister Chromatids; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Resolution of Sister Chromatid Cohesion; Transport of Ribonucleoproteins into the Host Nucleus; RHO GTPases Activate Formins; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins,77,High,1
P61225,Ras-related protein Rap-2b OS=Homo sapiens OX=9606 GN=RAP2B PE=1 SV=1,0,43.639,49,9,70,2,183,20.5,4.81,31637,,9,,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytosol;endosome;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00009, Pf00071, Pf02421, Pf08477",5912,ENSG00000181467.4,RAP2B,3,,,Neutrophil degranulation,3,High,1
P06213,Insulin receptor OS=Homo sapiens OX=9606 GN=INSR PE=1 SV=4,0,43.554,10,11,35,8,1382,156.2,6.2,12996,,11,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,membrane;organelle lumen,catalytic activity;nucleotide binding;protein binding;receptor activity;signal transducer activity,"Pf00041, Pf00069, Pf00757, Pf01030, Pf07714",3643,ENSG00000171105.13,INSR,19,Longevity regulating pathway - multiple species; Insulin resistance; Adherens junction; Rap1 signaling pathway; Ovarian steroidogenesis; Ras signaling pathway; mTOR signaling pathway; Phospholipase D signaling pathway; Insulin signaling pathway; Longevity regulating pathway; Type II diabetes mellitus; Regulation of lipolysis in adipocytes; cGMP-PKG signaling pathway; Non-alcoholic fatty liver disease (NAFLD); FoxO signaling pathway; Aldosterone-regulated sodium reabsorption; HIF-1 signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway,AMP-activated Protein Kinase (AMPK) Signaling; Selenium Micronutrient Network; Vitamin B12 Metabolism; Type II diabetes mellitus; Folate Metabolism; AGE/RAGE pathway; Nanoparticle triggered autophagic cell death; Transcription factor regulation in adipogenesis; Angiopoietin Like Protein 8 Regulatory Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Leptin Insulin Overlap; Insulin Signaling; DNA Damage Response (only ATM dependent),"Signal attenuation; Insulin receptor recycling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; IRS activation",43,High,1
Q29RF7,Sister chromatid cohesion protein PDS5 homolog A OS=Homo sapiens OX=9606 GN=PDS5A PE=1 SV=1,0,43.469,10,10,29,8,1337,150.7,7.91,13203,,10,,cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;cytosol;membrane;nucleus,protein binding,,23244,ENSG00000121892.14,PDS5A,4,,,Cohesin Loading onto Chromatin; Establishment of Sister Chromatid Cohesion; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion,12,High,1
P46734,Dual specificity mitogen-activated protein kinase kinase 3 OS=Homo sapiens OX=9606 GN=MAP2K3 PE=1 SV=2,0,43.449,23,7,43,7,347,39.3,7.43,19115,,7,,defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf07714, Pf14531",5606,ENSG00000034152.18,MAP2K3,17,Epstein-Barr virus infection; GnRH signaling pathway; Fc epsilon RI signaling pathway; MAPK signaling pathway; TNF signaling pathway; Amyotrophic lateral sclerosis (ALS); Toll-like receptor signaling pathway; Rap1 signaling pathway; Influenza A; Inflammatory mediator regulation of TRP channels; Toxoplasmosis,"Regulation of toll-like receptor signaling pathway; Physiological and Pathological Hypertrophy  of the Heart; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated Cell Adhesion; IL-1 signaling pathway; Human Thyroid Stimulating Hormone (TSH) signaling pathway; Signaling Pathways in Glioblastoma; TNF alpha Signaling Pathway; Structural Pathway of Interleukin 1 (IL-1); Cardiac Hypertrophic Response; Endoderm Differentiation; Focal Adhesion; TGF-beta Signaling Pathway; MAPK Signaling Pathway; 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; ESC Pluripotency Pathways; MAPK Cascade; Insulin Signaling; Interferon type I signaling pathways; Senescence and Autophagy in Cancer; Toll-like receptor signaling pathway",Activated TLR4 signalling; activated TAK1 mediates p38 MAPK activation; Oxidative Stress Induced Senescence,62,High,1
O00712,Nuclear factor 1 B-type OS=Homo sapiens OX=9606 GN=NFIB PE=1 SV=2,0,43.436,24,6,41,4,420,47.4,8.87,15558,0,6,1,cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process,nucleus,DNA binding,"Pf00859, Pf03165, Pf10524, Pf15362",4781,ENSG00000147862.15,NFIB,9,,Pathways Affected in Adenoid Cystic Carcinoma,RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination,5,High,1
Q9Y2Q5,Ragulator complex protein LAMTOR2 OS=Homo sapiens OX=9606 GN=LAMTOR2 PE=1 SV=1,0,43.428,59,4,35,4,125,13.5,5.4,14971,,4,,metabolic process;regulation of biological process;response to stimulus;transport,endosome;membrane;vacuole,protein binding;structural molecule activity,Pf03259,28956,ENSG00000116586.11,LAMTOR2,1,mTOR signaling pathway,,Energy dependent regulation of mTOR by LKB1-AMPK; Neutrophil degranulation; MAP2K and MAPK activation; Regulation of PTEN gene transcription; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Macroautophagy; Interleukin-20 family signaling,26,High,1
A6NHL2,Tubulin alpha chain-like 3 OS=Homo sapiens OX=9606 GN=TUBAL3 PE=1 SV=2,0,43.398,14,8,339,2,446,49.9,6.05,164827,0,8,1,cell organization and biogenesis,cytoplasm;cytoskeleton,catalytic activity;nucleotide binding;structural molecule activity,"Pf00091, Pf03953",79861,ENSG00000178462.11,TUBAL3,10,Apoptosis; Gap junction; Phagosome; Pathogenic Escherichia coli infection,Pathogenic Escherichia coli infection; Parkin-Ubiquitin Proteasomal System pathway,COPI-independent Golgi-to-ER retrograde traffic; COPI-dependent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Cilium Assembly; Recruitment of NuMA to mitotic centrosomes; Translocation of GLUT4 to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Separation of Sister Chromatids; COPI-mediated anterograde transport; HSP90 chaperone cycle for steroid hormone receptors (SHR); The role of GTSE1 in G2/M progression after G2 checkpoint; Kinesins; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; Recycling pathway of L1; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; Post-chaperonin tubulin folding pathway; MHC class II antigen presentation,62,High,1
P40121,Macrophage-capping protein OS=Homo sapiens OX=9606 GN=CAPG PE=1 SV=2,0,43.363,32,8,20,8,348,38.5,6.19,8702,,8,,cell organization and biogenesis;regulation of biological process,cytoplasm;extracellular;nucleus,protein binding,Pf00626,822,ENSG00000042493.15,CAPG,2,,TYROBP Causal Network,,1,High,1
Q8WVY7,Ubiquitin-like domain-containing CTD phosphatase 1 OS=Homo sapiens OX=9606 GN=UBLCP1 PE=1 SV=2,0,43.356,30,9,52,9,318,36.8,6.46,22165,,9,,metabolic process,nucleus,catalytic activity;protein binding,"Pf00240, Pf03031",134510,ENSG00000164332.7,UBLCP1,5,,,,0,High,1
A0PJW6,Transmembrane protein 223 OS=Homo sapiens OX=9606 GN=TMEM223 PE=1 SV=1,0,43.235,34,6,70,6,202,22,11.02,29585,0,6,2,,membrane;mitochondrion,,Pf14640,79064,ENSG00000168569.7,TMEM223,11,,,,0,High,1
Q9Y570,Protein phosphatase methylesterase 1 OS=Homo sapiens OX=9606 GN=PPME1 PE=1 SV=3,0,43.154,25,8,101,8,386,42.3,5.97,39356,4.27,6,3,metabolic process;regulation of biological process,,catalytic activity;enzyme regulator activity;protein binding,"Pf00561, Pf12695, Pf12697",51400,ENSG00000214517.9,PPME1,11,,,Cyclin A/B1/B2 associated events during G2/M transition,5,High,1
P08397,Porphobilinogen deaminase OS=Homo sapiens OX=9606 GN=HMBS PE=1 SV=2,0,43.148,20,8,79,7,361,39.3,7.18,33595,,8,,metabolic process,cytoplasm;cytosol,catalytic activity,"Pf01379, Pf03900",3145,ENSG00000281702.3; ENSG00000256269.7,HMBS,11; CHR_HG2217_PATCH,Porphyrin and chlorophyll metabolism; Metabolic pathways,Heme Biosynthesis,Heme biosynthesis,6,High,1
Q8NHH9,Atlastin-2 OS=Homo sapiens OX=9606 GN=ATL2 PE=1 SV=2,0,43.14,14,7,60,7,583,66.2,5.48,25223,,7,,cell organization and biogenesis;transport,endoplasmic reticulum;membrane,catalytic activity;nucleotide binding;protein binding,Pf02263,64225,ENSG00000119787.13,ATL2,2,,,,0,High,1
Q96BS2,Calcineurin B homologous protein 3 OS=Homo sapiens OX=9606 GN=TESC PE=1 SV=3,0,43.126,42,8,28,8,214,24.7,4.93,11970,,8,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus,enzyme regulator activity;metal ion binding;protein binding,Pf13405,54997,ENSG00000088992.17,TESC,12,,,,0,High,1
Q8TBX8,Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma OS=Homo sapiens OX=9606 GN=PIP4K2C PE=1 SV=3,0,43.125,20,7,32,7,421,47.3,6.84,15533,,7,,metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;vacuole,catalytic activity;nucleotide binding;protein binding,Pf01504,79837,ENSG00000166908.17,PIP4K2C,12,Inositol phosphate metabolism; Regulation of actin cytoskeleton; Phosphatidylinositol signaling system,Regulation of Actin Cytoskeleton,"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs at the plasma membrane; Synthesis of PIPs in the nucleus",22,High,1
Q9HBL7,Plasminogen receptor (KT) OS=Homo sapiens OX=9606 GN=PLGRKT PE=1 SV=1,0,43.114,33,5,138,5,147,17.2,9.58,58957,1.7,5,1,defense response;regulation of biological process;response to stimulus,membrane;mitochondrion,protein binding,Pf10166,55848,ENSG00000107020.9,PLGRKT,9,,,,0,High,1
Q6P1A2,Lysophospholipid acyltransferase 5 OS=Homo sapiens OX=9606 GN=LPCAT3 PE=1 SV=1,0,43.092,21,8,86,8,487,56,8.69,36473,,8,,metabolic process;regulation of biological process,endoplasmic reticulum;membrane,catalytic activity,Pf03062,10162,ENSG00000111684.10,LPCAT3,12,Glycerophospholipid metabolism,,Acyl chain remodelling of PS; Acyl chain remodelling of PE; Acyl chain remodelling of PC,8,High,1
Q99611,"Selenide, water dikinase 2 OS=Homo sapiens OX=9606 GN=SEPHS2 PE=1 SV=3",0,43.082,25,6,43,6,448,47.3,5.88,14270,,6,,metabolic process,cytosol,catalytic activity;nucleotide binding,"Pf00586, Pf02769",22928,ENSG00000179918.18,SEPHS2,16,Metabolic pathways; Selenocompound metabolism,Selenium Micronutrient Network; Selenium Metabolism and Selenoproteins,Selenocysteine synthesis,8,High,1
Q5SWX8,Protein odr-4 homolog OS=Homo sapiens OX=9606 GN=ODR4 PE=1 SV=1,0,43.074,17,7,39,7,454,51.1,5.92,19766,,7,,metabolic process,membrane,catalytic activity;metal ion binding,"Pf00848, Pf14778",54953,ENSG00000157181.15,C1orf27; ODR4,1,,,,0,High,1
Q9Y3Y2,Chromatin target of PRMT1 protein OS=Homo sapiens OX=9606 GN=CHTOP PE=1 SV=2,0,43.066,23,5,82,5,248,26.4,12.23,34346,,5,,metabolic process;regulation of biological process;transport,nucleus,DNA binding;nucleotide binding;protein binding;RNA binding,Pf13865,26097,ENSG00000160679.12,CHTOP,1,,,Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing,9,High,1
O00233,26S proteasome non-ATPase regulatory subunit 9 OS=Homo sapiens OX=9606 GN=PSMD9 PE=1 SV=3,0,42.994,48,7,52,7,223,24.7,6.95,24713,,7,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus,protein binding,"Pf04495, Pf13180",5715,ENSG00000110801.13,PSMD9,12,,Proteasome Degradation; Parkin-Ubiquitin Proteasomal System pathway,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,150,High,1
Q99570,Phosphoinositide 3-kinase regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PIK3R4 PE=1 SV=3,0,42.948,11,11,28,11,1358,153,7.17,9753,,11,,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoskeleton;cytosol;endosome;membrane;vacuole,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf00400",30849,ENSG00000196455.7,PIK3R4,3,Autophagy,Focal Adhesion; Angiopoietin Like Protein 8 Regulatory Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Insulin Signaling; Regulation of Actin Cytoskeleton; DNA Damage Response (only ATM dependent),PI3K Cascade; Toll Like Receptor 9 (TLR9) Cascade; Interleukin-7 signaling; RHO GTPases Activate NADPH Oxidases; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; Macroautophagy,35,High,1
Q9Y6X5,Bis(5'-adenosyl)-triphosphatase ENPP4 OS=Homo sapiens OX=9606 GN=ENPP4 PE=1 SV=3,0,42.916,22,6,40,6,453,51.6,6.15,20498,4.87,5,1,coagulation;metabolic process;regulation of biological process;transport,membrane,catalytic activity;metal ion binding,"Pf01663, Pf08665",22875,ENSG00000001561.6,ENPP4,6,Purine metabolism,,Neutrophil degranulation,4,High,1
P37198,Nuclear pore glycoprotein p62 OS=Homo sapiens OX=9606 GN=NUP62 PE=1 SV=3,0,42.884,19,6,24,6,522,53.2,5.31,10802,0,6,1,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;membrane;nucleus,protein binding;structural molecule activity;transporter activity,Pf05064,23636,ENSG00000213024.11,NUP62,19,RNA transport,,Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins,64,High,1
P05496,"ATP synthase F(0) complex subunit C1, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5MC1 PE=1 SV=2",0,42.837,23,3,379,3,136,14.3,9.74,187704,0,3,1,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion,catalytic activity;protein binding;transporter activity,Pf00137,516,ENSG00000159199.13,ATP5G1,17,Oxidative phosphorylation; Huntington's disease; Alzheimer's disease; Metabolic pathways; Parkinson's disease,Electron Transport Chain; Oxidative phosphorylation,Cristae formation; Mitochondrial protein import; Formation of ATP by chemiosmotic coupling; Metabolism of proteins,16,High,1
Q9NRL3,Striatin-4 OS=Homo sapiens OX=9606 GN=STRN4 PE=1 SV=2,0,42.819,16,7,41,6,753,80.5,5.4,15467,,7,,,cytoplasm;membrane,protein binding,"Pf00400, Pf08232",29888,ENSG00000090372.14,STRN4,19,,,,0,High,1
P58546,Myotrophin OS=Homo sapiens OX=9606 GN=MTPN PE=1 SV=2,0,42.793,47,4,105,4,118,12.9,5.52,53393,9.36,3,2,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,DNA binding;protein binding,"Pf00023, Pf12796, Pf13606, Pf13637, Pf13857",767558; 136319,ENSG00000105887.10,LUZP6; MTPN,7,,,,0,High,1
Q2TAA5,"GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase OS=Homo sapiens OX=9606 GN=ALG11 PE=1 SV=2",0,42.782,12,5,38,5,492,55.6,8.48,19555,,5,,metabolic process,endoplasmic reticulum;membrane,catalytic activity,"Pf00534, Pf13524, Pf13692",440138,ENSG00000253710.2,ALG11,13,Metabolic pathways; N-Glycan biosynthesis,,"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG11 causes ALG11-CDG (CDG-1p)",10,High,1
P19634,Sodium/hydrogen exchanger 1 OS=Homo sapiens OX=9606 GN=SLC9A1 PE=1 SV=2,0,42.744,9,6,15,6,815,90.7,7.21,7002,,6,,cell death;cell differentiation;cell organization and biogenesis;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;endoplasmic reticulum;membrane;mitochondrion,protein binding;structural molecule activity;transporter activity,Pf00999,6548,ENSG00000090020.10,SLC9A1,1,Salivary secretion; Pancreatic secretion; Regulation of actin cytoskeleton; Thyroid hormone signaling pathway; Cardiac muscle contraction; Gastric acid secretion; Proteoglycans in cancer; Adrenergic signaling in cardiomyocytes; cAMP signaling pathway; Bile secretion,Osteoclast Signaling; G Protein Signaling Pathways; Regulation of Actin Cytoskeleton,Hyaluronan uptake and degradation; Sodium/Proton exchangers,22,High,1
Q08209,Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform OS=Homo sapiens OX=9606 GN=PPP3CA PE=1 SV=1,0,42.742,17,8,42,4,521,58.7,5.86,18835,,8,,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;membrane;mitochondrion;nucleus,catalytic activity;metal ion binding;protein binding,Pf00149,5530,ENSG00000138814.16,PPP3CA,4,MAPK signaling pathway; Axon guidance; Renin secretion; Alzheimer's disease; Glutamatergic synapse; Glucagon signaling pathway; Th1 and Th2 cell differentiation; Natural killer cell mediated cytotoxicity; Calcium signaling pathway; VEGF signaling pathway; Oocyte meiosis; cGMP-PKG signaling pathway; HTLV-I infection; Osteoclast differentiation; Long-term potentiation; Dopaminergic synapse; Amyotrophic lateral sclerosis (ALS); Wnt signaling pathway; Tuberculosis; Oxytocin signaling pathway; B cell receptor signaling pathway; Amphetamine addiction; T cell receptor signaling pathway,Physiological and Pathological Hypertrophy  of the Heart; Energy Metabolism; MicroRNAs in cardiomyocyte hypertrophy; Alzheimers Disease; Spinal Cord Injury; Amyotrophic lateral sclerosis (ALS); T-Cell Receptor and Co-stimulatory Signaling; Cardiac Hypertrophic Response; Initiation of transcription and translation elongation at the HIV-1 LTR; G Protein Signaling Pathways; MAPK Signaling Pathway; VEGFA-VEGFR2 Signaling Pathway; Mitochondrial Gene Expression; Serotonin and anxiety-related events; Serotonin and anxiety,Signaling by GPCR; FCERI mediated Ca+2 mobilization; DARPP-32 events; Ca2+ pathway; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT,56,High,1
Q9H3H3,UPF0696 protein C11orf68 OS=Homo sapiens OX=9606 GN=C11orf68 PE=1 SV=3,0,42.731,25,7,86,7,292,31.4,6.32,40423,,7,,,,,,,,,,,,,0,High,1
Q16352,Alpha-internexin OS=Homo sapiens OX=9606 GN=INA PE=1 SV=2,0,42.687,4,5,513,1,499,55.4,5.4,279261,0,5,1,cell differentiation;cell organization and biogenesis;development,cytoskeleton;membrane,structural molecule activity,"Pf00038, Pf04732",9118,ENSG00000148798.10,INA,10,,,,0,High,1
Q6IC98,GRAM domain-containing protein 4 OS=Homo sapiens OX=9606 GN=GRAMD4 PE=1 SV=1,0,42.678,20,11,40,11,578,66.4,8.84,16997,,11,,cell death;regulation of biological process,membrane;mitochondrion,,"Pf02893, Pf08372",23151,ENSG00000075240.16,GRAMD4,22,,,,0,High,1
Q8WUX9,Charged multivesicular body protein 7 OS=Homo sapiens OX=9606 GN=CHMP7 PE=1 SV=1,0,42.671,23,8,21,8,453,50.9,5.35,9148,,8,,cell organization and biogenesis;transport,chromosome;cytoplasm;cytosol;nucleus,protein binding;transporter activity,Pf03357,91782,ENSG00000147457.13,CHMP7,8,Endocytosis,,Budding and maturation of HIV virion; Macroautophagy; Endosomal Sorting Complex Required For Transport (ESCRT),12,High,1
O43598,2'-deoxynucleoside 5'-phosphate N-hydrolase 1 OS=Homo sapiens OX=9606 GN=DNPH1 PE=1 SV=1,0,42.661,29,5,97,5,174,19.1,5.05,46480,,5,,cell differentiation;cell proliferation;metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,Pf05014,10591,ENSG00000112667.12,C6orf108; DNPH1,6,,,Purine catabolism,4,High,1
O00391,Sulfhydryl oxidase 1 OS=Homo sapiens OX=9606 GN=QSOX1 PE=1 SV=3,0,42.603,16,8,32,8,747,82.5,8.92,11489,,8,,cellular homeostasis;metabolic process;regulation of biological process;transport,extracellular;Golgi;membrane;organelle lumen,catalytic activity,"Pf00085, Pf04777, Pf13905",5768,ENSG00000116260.16,QSOX1,1,,,Platelet degranulation ; Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Neutrophil degranulation,11,High,1
Q8NDA8,Maestro heat-like repeat-containing protein family member 1 OS=Homo sapiens OX=9606 GN=MROH1 PE=2 SV=3,0,42.584,8,10,34,10,1641,181.1,6.89,12620,,10,,,,protein binding,,727957,ENSG00000179832.17,HEATR7A; MROH1,8,,,,0,High,1
O14879,Interferon-induced protein with tetratricopeptide repeats 3 OS=Homo sapiens OX=9606 GN=IFIT3 PE=1 SV=1,0,42.515,31,11,31,10,490,56,5.2,9980,,11,,defense response;regulation of biological process;response to stimulus,cytoplasm;cytosol;mitochondrion,protein binding,"Pf13414, Pf13424, Pf13432, Pf14559",3437,ENSG00000119917.13,IFIT3,10,,,Interferon alpha/beta signaling,4,High,1
O43447,Peptidyl-prolyl cis-trans isomerase H OS=Homo sapiens OX=9606 GN=PPIH PE=1 SV=1,0,42.514,42,6,130,6,177,19.2,8.07,52906,,6,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;nucleus;spliceosomal complex,catalytic activity;protein binding,Pf00160,10465,ENSG00000171960.10,PPIH,1,Spliceosome,,mRNA Splicing - Major Pathway,5,High,1
O60783,"28S ribosomal protein S14, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS14 PE=1 SV=1",0,42.506,34,4,116,4,128,15.1,11.41,49872,0,4,1,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,RNA binding;structural molecule activity,Pf00253,63931,ENSG00000120333.4,MRPS14,1,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
P29536,Leiomodin-1 OS=Homo sapiens OX=9606 GN=LMOD1 PE=1 SV=3,0,42.492,17,9,43,9,600,67,9.33,23051,,9,,cell organization and biogenesis;regulation of biological process,cytoplasm;cytoskeleton;cytosol;membrane,protein binding,Pf03250,25802,ENSG00000163431.12,LMOD1,1,,,Smooth Muscle Contraction,2,High,1
Q99584,Protein S100-A13 OS=Homo sapiens OX=9606 GN=S100A13 PE=1 SV=1,0,42.492,47,6,194,6,98,11.5,6.16,84877,,6,,regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;membrane;nucleus;vacuole,metal ion binding;protein binding,Pf01023,6284,ENSG00000189171.14,S100A13,1,,,,0,High,1
Q9Y3Q8,TSC22 domain family protein 4 OS=Homo sapiens OX=9606 GN=TSC22D4 PE=1 SV=2,0,42.476,30,10,39,7,395,41,7.21,14390,,10,,cell organization and biogenesis;metabolic process;regulation of biological process;reproduction,cytoplasm;nucleus,protein binding,"Pf01166, Pf04977, Pf06005, Pf06156",81628,ENSG00000166925.8,TSC22D4,7,,,,0,High,1
Q9H008,Phospholysine phosphohistidine inorganic pyrophosphate phosphatase OS=Homo sapiens OX=9606 GN=LHPP PE=1 SV=2,0,42.457,29,6,69,6,270,29.1,6.15,25813,,6,,metabolic process,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;protein binding;receptor activity;signal transducer activity,"Pf13242, Pf13344",64077,ENSG00000107902.13,LHPP,10,Oxidative phosphorylation,,Purine ribonucleoside monophosphate biosynthesis,5,High,1
Q96M27,Protein PRRC1 OS=Homo sapiens OX=9606 GN=PRRC1 PE=1 SV=1,0,42.445,19,7,52,7,445,46.7,5.83,21142,,7,,,Golgi,protein binding,Pf01931,133619,ENSG00000164244.20,PRRC1,5,,,,0,High,1
Q96CT7,Coiled-coil domain-containing protein 124 OS=Homo sapiens OX=9606 GN=CCDC124 PE=1 SV=1,0,42.442,39,9,46,9,223,25.8,9.54,17640,0,9,1,cell division,cytoplasm;cytoskeleton,RNA binding,Pf06244,115098,ENSG00000007080.10,CCDC124,19,,,,0,High,1
O43148,mRNA cap guanine-N7 methyltransferase OS=Homo sapiens OX=9606 GN=RNMT PE=1 SV=1,0,42.419,22,8,32,8,476,54.8,6.61,14545,,8,,metabolic process,nucleus,catalytic activity;protein binding;RNA binding,Pf03291,8731,ENSG00000101654.17,RNMT,18,mRNA surveillance pathway,mRNA Processing,RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; RNA Pol II CTD phosphorylation and interaction with CE; mRNA Capping,14,High,1
Q17RN3,Protein FAM98C OS=Homo sapiens OX=9606 GN=FAM98C PE=2 SV=1,0,42.416,32,8,34,8,349,37.3,7.18,14198,1.63,8,1,,,,Pf10239,147965,ENSG00000130244.12,FAM98C,19,,,,0,High,1
P15927,Replication protein A 32 kDa subunit OS=Homo sapiens OX=9606 GN=RPA2 PE=1 SV=1,0,42.411,37,5,41,5,270,29.2,6.15,14864,,5,,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,chromosome;nucleus,DNA binding;protein binding,Pf08784,6118,ENSG00000117748.9,RPA2,1,Mismatch repair; DNA replication; Nucleotide excision repair; Fanconi anemia pathway; Homologous recombination,miRNA Regulation of DNA Damage Response; Retinoblastoma (RB) in Cancer; G1 to S cell cycle control; DNA Replication; DNA Damage Response,Translesion Synthesis by POLH; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Activation of the pre-replicative complex; Termination of translesion DNA synthesis; Translesion synthesis by POLI; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Meiotic recombination; Removal of the Flap Intermediate; Regulation of TP53 Activity through Phosphorylation; PCNA-Dependent Long Patch Base Excision Repair; G2/M DNA damage checkpoint; Translesion synthesis by POLK; Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Gap-filling DNA repair synthesis and ligation in TC-NER; Regulation of HSF1-mediated heat shock response; Presynaptic phase of homologous DNA pairing and strand exchange; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Fanconi Anemia Pathway; HSF1 activation; M/G1 Transition; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA); Removal of the Flap Intermediate from the C-strand,81,High,1
P62306,Small nuclear ribonucleoprotein F OS=Homo sapiens OX=9606 GN=SNRPF PE=1 SV=1,0,42.399,47,5,53,5,86,9.7,4.67,26457,,5,,cell organization and biogenesis;metabolic process;transport,cytoplasm;cytosol;nucleus;spliceosomal complex,protein binding;RNA binding,Pf01423,6636,ENSG00000139343.10,SNRPF,12,Spliceosome,mRNA Processing,SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; snRNP Assembly; Cleavage of Growing Transcript in the Termination Region,16,High,1
Q9BX46,RNA-binding protein 24 OS=Homo sapiens OX=9606 GN=RBM24 PE=1 SV=1,0,42.379,25,6,66,6,236,24.8,8.51,29924,,6,,cell differentiation;regulation of biological process,cytoplasm;cytosol;nucleus,RNA binding,"Pf00076, Pf13893, Pf14259",221662,ENSG00000112183.14,RBM24,6,,,,0,High,1
Q9H832,Ubiquitin-conjugating enzyme E2 Z OS=Homo sapiens OX=9606 GN=UBE2Z PE=1 SV=2,0,42.362,17,6,34,6,354,38.2,5.62,14524,,6,,cell death;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00179, Pf05743",65264,ENSG00000159202.17,UBE2Z,17,Ubiquitin mediated proteolysis,,Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation,9,High,1
Q8TBA6,Golgin subfamily A member 5 OS=Homo sapiens OX=9606 GN=GOLGA5 PE=1 SV=3,0,42.351,17,9,17,9,731,83,5.83,6844,,9,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,Golgi;membrane,catalytic activity;motor activity;protein binding;structural molecule activity;transporter activity,"Pf00038, Pf01496, Pf01576, Pf02463, Pf03961, Pf04111, Pf04156, Pf04912, Pf05557, Pf05701, Pf07888, Pf08317, Pf09726, Pf09787, Pf10174, Pf11559, Pf12128, Pf13166, Pf13514, Pf13654",9950,ENSG00000066455.12,GOLGA5,14,,,Intra-Golgi traffic,4,High,1
Q86Y56,"Dynein assembly factor 5, axonemal OS=Homo sapiens OX=9606 GN=DNAAF5 PE=1 SV=4",0,42.304,11,8,36,8,855,93.5,6.42,16415,,8,,cell organization and biogenesis;cellular component movement,cytoplasm,protein binding,,54919,ENSG00000164818.15,HEATR2; DNAAF5,7,,,,0,High,1
O14672,Disintegrin and metalloproteinase domain-containing protein 10 OS=Homo sapiens OX=9606 GN=ADAM10 PE=1 SV=1,0,42.231,13,8,52,8,748,84.1,7.77,18030,,8,,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;Golgi;membrane;nucleus;organelle lumen,catalytic activity;metal ion binding;protein binding,"Pf00200, Pf01421, Pf01562, Pf12785, Pf13574, Pf13582, Pf13583, Pf13688",102,ENSG00000137845.14,ADAM10,15,Alzheimer's disease; Epithelial cell signaling in Helicobacter pylori infection,Alzheimers Disease; Copper homeostasis; Canonical  and Non-canonical Notch signaling; Hypertrophy Model,Collagen degradation; Post-translational protein phosphorylation; Activated NOTCH1 Transmits Signal to the Nucleus; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant; Signaling by NOTCH4; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Signaling by NOTCH3; EPH-ephrin mediated repulsion of cells; NOTCH2 Activation and Transmission of Signal to the Nucleus; Neutrophil degranulation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Signaling by EGFR,41,High,1
Q3ZCW2,Galectin-related protein OS=Homo sapiens OX=9606 GN=LGALSL PE=1 SV=2,0,42.23,45,5,27,5,172,19,5.35,13259,,5,,,,protein binding,Pf00337,29094,ENSG00000119862.12,LGALSL,2,,,,0,High,1
O00743,Serine/threonine-protein phosphatase 6 catalytic subunit OS=Homo sapiens OX=9606 GN=PPP6C PE=1 SV=1,0,42.214,28,8,64,8,305,35.1,5.69,26490,,8,,cell organization and biogenesis;metabolic process,cytoplasm;cytosol;membrane,catalytic activity;metal ion binding;protein binding,Pf00149,5537,ENSG00000119414.11,PPP6C,9,,,COPII (Coat Protein 2) Mediated Vesicle Transport,8,High,1
Q9BYN0,Sulfiredoxin-1 OS=Homo sapiens OX=9606 GN=SRXN1 PE=1 SV=2,0,42.185,49,6,32,6,137,14.3,8.19,14853,,6,,metabolic process;response to stimulus,cytoplasm;cytosol,antioxidant activity;catalytic activity;nucleotide binding;protein binding,Pf02195,140809,ENSG00000271303.1,SRXN1,20,,Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling,,1,High,1
O60879,Protein diaphanous homolog 2 OS=Homo sapiens OX=9606 GN=DIAPH2 PE=1 SV=1,0,42.169,8,9,31,9,1101,125.5,6.58,13250,,9,,cell differentiation;cell organization and biogenesis;development,cytoplasm;cytosol;endoplasmic reticulum;endosome,protein binding,"Pf02181, Pf06367, Pf06371",1730,ENSG00000147202.17,DIAPH2,X,Regulation of actin cytoskeleton,,,1,High,1
Q01844,RNA-binding protein EWS OS=Homo sapiens OX=9606 GN=EWSR1 PE=1 SV=1,0,42.106,12,6,28,6,656,68.4,9.33,15064,,6,,metabolic process;regulation of biological process,cytoplasm;membrane;nucleus,metal ion binding;protein binding;RNA binding,"Pf00076, Pf00641, Pf14259",2130,ENSG00000182944.17,EWSR1,22,Transcriptional misregulation in cancer,,,1,High,1
Q99700,Ataxin-2 OS=Homo sapiens OX=9606 GN=ATXN2 PE=1 SV=2,0,42.099,8,7,28,7,1313,140.2,9.57,12304,,7,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;Golgi;membrane,protein binding;RNA binding,"Pf06741, Pf07145, Pf09770, Pf14438",6311,ENSG00000204842.14,ATXN2,12,,Parkinsons Disease Pathway; EGF/EGFR Signaling Pathway,,2,High,1
Q9BW72,"HIG1 domain family member 2A, mitochondrial OS=Homo sapiens OX=9606 GN=HIGD2A PE=1 SV=1",0,42.085,55,3,59,3,106,11.5,10.2,30466,,3,,metabolic process;regulation of biological process;transport,membrane;mitochondrion,,Pf04588,192286,ENSG00000146066.2,HIGD2A,5,,,,0,High,1
Q96JA1,Leucine-rich repeats and immunoglobulin-like domains protein 1 OS=Homo sapiens OX=9606 GN=LRIG1 PE=1 SV=2,0,42.048,9,9,31,9,1093,119,7.09,12932,,9,,,membrane,protein binding,"Pf00047, Pf07679, Pf07686, Pf08205, Pf12799, Pf13855, Pf13895, Pf13927, Pf15369",26018,ENSG00000282243.1; ENSG00000144749.13,LRIG1,3; CHR_HG2235_PATCH,,,Negative regulation of MET activity; Signaling by EGFR,5,High,1
Q9UKK9,ADP-sugar pyrophosphatase OS=Homo sapiens OX=9606 GN=NUDT5 PE=1 SV=1,0,42.034,28,6,37,6,219,24.3,4.94,18066,,6,,cell organization and biogenesis;metabolic process,cytosol;nucleus,catalytic activity;metal ion binding;protein binding;RNA binding,Pf00293,11164,ENSG00000165609.12,NUDT5,10,Purine metabolism,,Phosphate bond hydrolysis by NUDT proteins,6,High,1
P67870,Casein kinase II subunit beta OS=Homo sapiens OX=9606 GN=CSNK2B PE=1 SV=1,0,41.992,24,4,62,4,215,24.9,5.55,24392,1.76,4,1,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,chromosome;cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen,catalytic activity;enzyme regulator activity;metal ion binding;protein binding,Pf01214,1460,ENSG00000224774.7; ENSG00000230700.9; ENSG00000206406.9; ENSG00000204435.13; ENSG00000232960.10; ENSG00000224398.7; ENSG00000228875.8,CSNK2B,6; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_COX_CTG1,Measles; NF-kappa B signaling pathway; Tight junction; Herpes simplex infection; Wnt signaling pathway; Epstein-Barr virus infection; Adherens junction; Ribosome biogenesis in eukaryotes,,WNT mediated activation of DVL; Condensation of Prometaphase Chromosomes; Regulation of PTEN stability and activity; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Signal transduction by L1; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Synthesis of PC; Neutrophil degranulation; Receptor Mediated Mitophagy; Regulation of TP53 Activity through Phosphorylation,47,High,1
P17813,Endoglin OS=Homo sapiens OX=9606 GN=ENG PE=1 SV=2,0,41.962,11,6,39,6,658,70.5,6.61,17955,0,6,1,cell differentiation;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport,cell surface;membrane,catalytic activity;protein binding;receptor activity;signal transducer activity;transporter activity,Pf00100,2022,ENSG00000106991.13,ENG,9,,Hypothesized Pathways in Pathogenesis of Cardiovascular Disease; TGF-beta Receptor Signaling,,2,High,1
Q9UHD2,Serine/threonine-protein kinase TBK1 OS=Homo sapiens OX=9606 GN=TBK1 PE=1 SV=1,0,41.923,18,9,34,9,729,83.6,6.79,11892,,9,,cell proliferation;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf07714",29110,ENSG00000183735.9,TBK1,12,Hepatitis C; Cytosolic DNA-sensing pathway; Influenza A; Toll-like receptor signaling pathway; Hepatitis B; Ras signaling pathway; Herpes simplex infection; Measles; Epstein-Barr virus infection; RIG-I-like receptor signaling pathway; NOD-like receptor signaling pathway,Regulation of toll-like receptor signaling pathway; TNF alpha Signaling Pathway; TLR4 Signaling and Tolerance; Toll-like Receptor Signaling; RIG-I-like Receptor Signaling; Toll-like receptor signaling pathway,IRF3 mediated activation of type 1 IFN; STAT6-mediated induction of chemokines; TICAM1-dependent activation of IRF3/IRF7; IRF3-mediated induction of type I IFN; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; Negative regulators of DDX58/IFIH1 signaling; TRAF6 mediated IRF7 activation; Regulation of innate immune responses to cytosolic DNA; TRAF3-dependent IRF activation pathway; Activated TLR4 signalling,38,High,1
P43487,Ran-specific GTPase-activating protein OS=Homo sapiens OX=9606 GN=RANBP1 PE=1 SV=1,0,41.901,38,5,54,5,201,23.3,5.29,21228,,5,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus,enzyme regulator activity;protein binding,Pf00638,5902,ENSG00000099901.16,RANBP1,22,Viral carcinogenesis; HTLV-I infection,,Rev-mediated nuclear export of HIV RNA,10,High,1
Q9P289,Serine/threonine-protein kinase 26 OS=Homo sapiens OX=9606 GN=STK26 PE=1 SV=2,0,41.899,19,8,71,1,416,46.5,5.29,33167,,8,,cell communication;cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;Golgi;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf07714",51765,ENSG00000134602.15,MST4; STK26,X,,,Apoptotic cleavage of cellular proteins,4,High,1
O43809,Cleavage and polyadenylation specificity factor subunit 5 OS=Homo sapiens OX=9606 GN=NUDT21 PE=1 SV=1,0,41.892,35,6,76,6,227,26.2,8.82,29064,,6,,cell organization and biogenesis;metabolic process,nucleus,catalytic activity;protein binding;RNA binding,Pf13869,11051,ENSG00000167005.13,NUDT21,16,mRNA surveillance pathway,mRNA Processing,Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs; mRNA 3'-end processing; mRNA Splicing - Major Pathway,13,High,1
Q6ZMZ3,Nesprin-3 OS=Homo sapiens OX=9606 GN=SYNE3 PE=1 SV=2,0,41.825,14,11,30,11,975,112.1,6.23,12883,,11,,cell organization and biogenesis;regulation of biological process,endoplasmic reticulum;membrane;nucleus,protein binding,Pf10541,161176,ENSG00000176438.12,SYNE3,14,,,,0,High,1
Q9NR99,Matrix-remodeling-associated protein 5 OS=Homo sapiens OX=9606 GN=MXRA5 PE=1 SV=3,0,41.825,4,8,24,8,2828,312,8.32,9445,10.73,8,1,response to stimulus,extracellular,protein binding,"Pf00047, Pf07679, Pf13855, Pf13895, Pf13927",25878,ENSG00000101825.7,MXRA5,X,,,,0,High,1
Q9BYN8,"28S ribosomal protein S26, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS26 PE=1 SV=1",0,41.814,32,7,51,7,205,24.2,10.39,21772,,7,,cell organization and biogenesis;metabolic process;response to stimulus,membrane;mitochondrion;ribosome,RNA binding,Pf14943,64949,ENSG00000125901.5,MRPS26,20,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
O15260,Surfeit locus protein 4 OS=Homo sapiens OX=9606 GN=SURF4 PE=1 SV=3,0,41.785,23,6,118,6,269,30.4,7.78,49012,,6,,cell organization and biogenesis;regulation of biological process;transport,endoplasmic reticulum;Golgi;membrane,protein binding,Pf02077,6836,ENSG00000280951.2; ENSG00000148248.13,SURF4,9; CHR_HG2030_PATCH,,,COPI-dependent Golgi-to-ER retrograde traffic; Neutrophil degranulation,8,High,1
Q92688,Acidic leucine-rich nuclear phosphoprotein 32 family member B OS=Homo sapiens OX=9606 GN=ANP32B PE=1 SV=1,0,41.779,20,6,110,5,251,28.8,4.06,46370,1.85,6,2,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;nucleus,protein binding,"Pf12799, Pf13855, Pf14580",10541,ENSG00000136938.8,ANP32B,9,,,,0,High,1
Q5VT25,Serine/threonine-protein kinase MRCK alpha OS=Homo sapiens OX=9606 GN=CDC42BPA PE=1 SV=1,0,41.764,7,10,73,8,1732,197.2,6.58,37247,,10,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;extracellular;Golgi,catalytic activity;metal ion binding;motor activity;nucleotide binding;protein binding;structural molecule activity,"Pf00038, Pf00069, Pf00130, Pf00169, Pf00433, Pf00769, Pf00780, Pf01442, Pf01576, Pf02463, Pf03999, Pf04012, Pf04111, Pf04156, Pf05483, Pf05557, Pf05622, Pf05667, Pf05701, Pf05911, Pf06160, Pf06785, Pf07714, Pf07888, Pf08317, Pf08826, Pf09726, Pf09730, Pf09755, Pf10174, Pf10498, Pf12037, Pf12128, Pf12718, Pf12795, Pf13514, Pf13851, Pf13868, Pf14362, Pf14531, Pf14915, Pf15558, Pf15619",8476,ENSG00000143776.18,CDC42BPA,1,,,,0,High,1
O75410,Transforming acidic coiled-coil-containing protein 1 OS=Homo sapiens OX=9606 GN=TACC1 PE=1 SV=2,0,41.752,18,10,34,9,805,87.7,4.88,15384,,10,,cell division;cell organization and biogenesis;cell proliferation;cellular component movement;regulation of biological process;transport,cytoplasm;cytoskeleton;membrane;nucleus,catalytic activity;motor activity;protein binding;transporter activity,"Pf01496, Pf01576, Pf02463, Pf04012, Pf05010, Pf05262, Pf05557, Pf06637, Pf12037, Pf12128, Pf13851",6867,ENSG00000147526.19,TACC1,8,,,,0,High,1
Q9NRD5,PRKCA-binding protein OS=Homo sapiens OX=9606 GN=PICK1 PE=1 SV=2,0,41.738,19,7,32,7,415,46.6,5.3,13457,,7,,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;Golgi;membrane;mitochondrion,metal ion binding;protein binding,"Pf00595, Pf03114, Pf06456",9463,ENSG00000100151.15,PICK1,22,,,Trafficking of GluR2-containing AMPA receptors; Cell surface interactions at the vascular wall,8,High,1
Q96L96,Alpha-protein kinase 3 OS=Homo sapiens OX=9606 GN=ALPK3 PE=1 SV=2,0,41.729,7,8,135,7,1907,201.1,7.58,54126,34.43,2,6,development;metabolic process,nucleus,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding;receptor activity;signal transducer activity,"Pf00047, Pf02440, Pf02816, Pf07679, Pf13895",57538,ENSG00000136383.6,ALPK3,15,,,,0,High,1
P18583-5,Isoform D of Protein SON OS=Homo sapiens OX=9606 GN=SON,0,41.723,9,11,27,11,2459,266.9,5.73,9648,2.38,10,1,cell organization and biogenesis;metabolic process;regulation of biological process,extracellular,DNA binding;protein binding;RNA binding,"Pf00035, Pf01585, Pf03154, Pf05109, Pf07174, Pf12526, Pf14709",6651,,SON,21,,,,0,High,1
O60229,Kalirin OS=Homo sapiens OX=9606 GN=KALRN PE=1 SV=3,0,41.708,4,7,41,6,2986,340,6.07,19568,,7,,,,,,,,,,,,,0,High,1
P06312,Immunoglobulin kappa variable 4-1 OS=Homo sapiens OX=9606 GN=IGKV4-1 PE=1 SV=1,0,41.689,45,5,94,4,121,13.4,5.25,49240,0,5,1,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity,"Pf07679, Pf07686",28908,ENSG00000211598.2,IGKV4-1,2,,,FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis,26,High,1
O43172,U4/U6 small nuclear ribonucleoprotein Prp4 OS=Homo sapiens OX=9606 GN=PRPF4 PE=1 SV=2,0,41.642,20,9,38,9,522,58.4,7.42,15439,,9,,metabolic process,nucleus;spliceosomal complex,protein binding;RNA binding,"Pf00400, Pf08799",9128,ENSG00000136875.12,PRPF4,9,Spliceosome,mRNA Processing,mRNA Splicing - Major Pathway,6,High,1
Q8IX04,Ubiquitin-conjugating enzyme E2 variant 3 OS=Homo sapiens OX=9606 GN=UEVLD PE=1 SV=2,0,41.615,18,7,60,7,471,52.2,7.09,22674,,7,,metabolic process;transport,,catalytic activity,"Pf00056, Pf00179, Pf02866, Pf05743",55293,ENSG00000151116.16,UEVLD,11,,,,0,High,1
Q9HD45,Transmembrane 9 superfamily member 3 OS=Homo sapiens OX=9606 GN=TM9SF3 PE=1 SV=2,0,41.605,15,6,20,6,589,67.8,7.21,6951,,6,,,membrane,,Pf02990,56889,ENSG00000077147.14,TM9SF3,10,,,,0,High,1
Q9Y2X7,ARF GTPase-activating protein GIT1 OS=Homo sapiens OX=9606 GN=GIT1 PE=1 SV=2,0,41.581,15,8,67,5,761,84.3,6.8,27660,,8,,regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,enzyme regulator activity;metal ion binding;protein binding,"Pf00023, Pf01412, Pf08518, Pf12205, Pf12796, Pf13637, Pf13857",28964,ENSG00000108262.15,GIT1,17,Epithelial cell signaling in Helicobacter pylori infection; Endocytosis; Regulation of actin cytoskeleton,Regulation of Actin Cytoskeleton,Ephrin signaling,8,High,1
O43556,Epsilon-sarcoglycan OS=Homo sapiens OX=9606 GN=SGCE PE=1 SV=6,0,41.503,23,7,39,7,437,49.8,6.55,15410,,7,,cell organization and biogenesis,cytoplasm;cytoskeleton;Golgi;membrane,,Pf05510,8910,ENSG00000127990.15,SGCE,7,,,,0,High,1
Q9BSF4,Mitochondrial import inner membrane translocase subunit Tim29 OS=Homo sapiens OX=9606 GN=TIMM29 PE=1 SV=2,0,41.492,23,4,52,4,260,29.2,8.09,22732,,4,,cell organization and biogenesis;transport,membrane;mitochondrion,protein binding,Pf10171,90580,ENSG00000142444.6,C19orf52; TIMM29,19,,,,0,High,1
Q9UKU0-1,Isoform 1 of Long-chain-fatty-acid--CoA ligase 6 OS=Homo sapiens OX=9606 GN=ACSL6,0,41.475,12,7,108,4,722,80.6,7.28,49961,,7,,metabolic process,membrane,catalytic activity;nucleotide binding;protein binding,Pf00501,23305,ENSG00000164398.12,ACSL6,5,,Fatty Acid Beta Oxidation; Fatty Acid Biosynthesis; PPAR signaling pathway,,3,High,1
P51580,Thiopurine S-methyltransferase OS=Homo sapiens OX=9606 GN=TPMT PE=1 SV=1,0,41.434,23,6,49,6,245,28.2,6.23,22253,,6,,metabolic process,cytoplasm;cytosol,catalytic activity,Pf05724,7172,ENSG00000137364.4,TPMT,6,Drug metabolism - other enzymes,Metapathway biotransformation; Methylation Pathways,Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency); Methylation,11,High,1
Q9P0K7,Ankycorbin OS=Homo sapiens OX=9606 GN=RAI14 PE=1 SV=2,0,41.393,12,9,36,9,980,110,6.21,13243,,9,,cell differentiation;metabolic process,cytoplasm;cytoskeleton;cytosol;mitochondrion;nucleus,protein binding,"Pf00023, Pf03961, Pf04111, Pf12796, Pf13606, Pf13637, Pf13857",26064,ENSG00000039560.13,RAI14,5,,,,0,High,1
P11279,Lysosome-associated membrane glycoprotein 1 OS=Homo sapiens OX=9606 GN=LAMP1 PE=1 SV=3,0,41.384,13,6,131,6,417,44.9,8.75,62904,0,6,1,cell death;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;cytosol;endosome;membrane;vacuole,protein binding;receptor activity,Pf01299,3916,ENSG00000185896.10,LAMP1,13,Phagosome; Lysosome; Tuberculosis,Senescence and Autophagy in Cancer,Neutrophil degranulation,7,High,1
O95721,Synaptosomal-associated protein 29 OS=Homo sapiens OX=9606 GN=SNAP29 PE=1 SV=1,0,41.377,43,8,45,8,258,29,5.81,19128,,8,,cell organization and biogenesis;metabolic process;transport,cytoplasm;cytosol;Golgi;membrane;vacuole,protein binding,"Pf00835, Pf05739",9342,ENSG00000099940.11,SNAP29,22,SNARE interactions in vesicular transport,,Intra-Golgi traffic; Neutrophil degranulation,8,High,1
P62330,ADP-ribosylation factor 6 OS=Homo sapiens OX=9606 GN=ARF6 PE=1 SV=2,0,41.372,39,5,76,5,175,20.1,8.95,29696,,5,,cell death;cell differentiation;cell division;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;Golgi;membrane,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding;signal transducer activity,"Pf00025, Pf00071, Pf00503, Pf04670, Pf08477, Pf09439",382,ENSG00000165527.6,ARF6,14,Ras signaling pathway; Endocytosis; Fc gamma R-mediated phagocytosis; Phospholipase D signaling pathway,VEGFA-VEGFR2 Signaling Pathway; EGF/EGFR Signaling Pathway; Insulin Signaling,MET receptor recycling; TBC/RABGAPs; Clathrin-mediated endocytosis,16,High,1
Q9UHN1,"DNA polymerase subunit gamma-2, mitochondrial OS=Homo sapiens OX=9606 GN=POLG2 PE=1 SV=1",0,41.367,21,8,32,8,485,54.9,8.35,13770,,8,,cell organization and biogenesis;metabolic process;response to stimulus,chromosome;mitochondrion;organelle lumen,catalytic activity;DNA binding;protein binding,Pf03129,11232,ENSG00000256525.6,POLG2,17,Metabolic pathways,,Transcriptional activation of mitochondrial biogenesis,4,High,1
Q92954,Proteoglycan 4 OS=Homo sapiens OX=9606 GN=PRG4 PE=1 SV=3,0,41.36,7,7,42,7,1404,151,9.51,12685,8.44,7,1,,,,,,,,,,,,0,High,1
Q9NSB8,Homer protein homolog 2 OS=Homo sapiens OX=9606 GN=HOMER2 PE=1 SV=1,0,41.312,26,10,45,7,354,40.6,6.38,17261,,10,,regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,protein binding;structural molecule activity,"Pf00568, Pf10234",9455,ENSG00000103942.12,HOMER2,15,Glutamatergic synapse; FoxO signaling pathway,,Neurexins and neuroligins,5,High,1
P37108,Signal recognition particle 14 kDa protein OS=Homo sapiens OX=9606 GN=SRP14 PE=1 SV=2,0,41.308,35,5,73,5,136,14.6,10.04,33868,,5,,cell organization and biogenesis;response to stimulus;transport,cytoplasm;cytosol;extracellular;nucleus;organelle lumen,protein binding;RNA binding,Pf02290,6727,ENSG00000140319.10,SRP14,15,Protein export,,Neutrophil degranulation; SRP-dependent cotranslational protein targeting to membrane,7,High,1
Q9BXJ8,Transmembrane protein 120A OS=Homo sapiens OX=9606 GN=TMEM120A PE=1 SV=1,0,41.243,18,6,83,6,343,40.6,8.98,32054,11.52,5,2,cell differentiation;cell organization and biogenesis,membrane;nucleus,,Pf07851,83862,ENSG00000189077.10,TMEM120A,7,,,,0,High,1
O75298,Reticulon-2 OS=Homo sapiens OX=9606 GN=RTN2 PE=1 SV=1,0,41.241,10,4,106,4,545,59.2,5.31,45652,,4,,regulation of biological process;transport,endoplasmic reticulum;membrane,protein binding,Pf02453,6253,ENSG00000125744.11,RTN2,19,,,,0,High,1
P35080,Profilin-2 OS=Homo sapiens OX=9606 GN=PFN2 PE=1 SV=3,0,41.203,26,4,95,4,140,15,6.99,43133,1.93,4,2,cell organization and biogenesis;regulation of biological process,cytoplasm;cytoskeleton,catalytic activity;protein binding,Pf00235,5217,ENSG00000070087.13,PFN2,3,Regulation of actin cytoskeleton; Shigellosis; Rap1 signaling pathway; Salmonella infection,Association Between Physico-Chemical Features and Toxicity Associated Pathways,RHO GTPases Activate Formins; Signaling by ROBO receptors,12,High,1
Q8N668,COMM domain-containing protein 1 OS=Homo sapiens OX=9606 GN=COMMD1 PE=1 SV=1,0,41.194,37,4,25,4,190,21.2,6.2,11736,,4,,metabolic process;regulation of biological process;transport,cytoplasm;cytosol;endosome;membrane;nucleus,metal ion binding;protein binding,Pf07258,150684,ENSG00000173163.10,COMMD1,2,,Copper homeostasis,Neddylation,4,High,1
P49959,Double-strand break repair protein MRE11 OS=Homo sapiens OX=9606 GN=MRE11 PE=1 SV=3,0,41.159,16,10,46,9,708,80.5,5.9,17324,0,10,1,cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;cytosol;nucleus,catalytic activity;DNA binding;metal ion binding;protein binding,"Pf00149, Pf04152",4361,ENSG00000020922.12,MRE11A; MRE11,11,Homologous recombination; Non-homologous end-joining,miRNA Regulation of DNA Damage Response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM Signaling Network in Development and Disease; Non-homologous end joining; DNA Damage Response,G2/M DNA damage checkpoint; IRF3-mediated induction of type I IFN; Presynaptic phase of homologous DNA pairing and strand exchange; Nonhomologous End-Joining (NHEJ); Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Meiotic recombination; Sensing of DNA Double Strand Breaks; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); HDR through MMEJ (alt-NHEJ); DNA Damage/Telomere Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; Resolution of D-loop Structures through Holliday Junction Intermediates,47,High,1
Q7L5D6,Golgi to ER traffic protein 4 homolog OS=Homo sapiens OX=9606 GN=GET4 PE=1 SV=1,0,41.158,34,9,47,9,327,36.5,5.41,18418,,9,,regulation of biological process;transport,cytoplasm;cytosol,protein binding,Pf04190,51608,ENSG00000239857.6,GET4,7,,,,0,High,1
Q96GX9,Methylthioribulose-1-phosphate dehydratase OS=Homo sapiens OX=9606 GN=APIP PE=1 SV=1,0,41.142,25,4,44,4,242,27.1,7.12,22162,,4,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm,catalytic activity;metal ion binding;protein binding,Pf00596,51074,ENSG00000149089.12,APIP,11,Cysteine and methionine metabolism; Metabolic pathways,,Methionine salvage pathway,7,High,1
P62316,Small nuclear ribonucleoprotein Sm D2 OS=Homo sapiens OX=9606 GN=SNRPD2 PE=1 SV=1,0,41.132,54,6,78,6,118,13.5,9.91,34716,,6,,cell organization and biogenesis;metabolic process;transport,cytoplasm;cytosol;nucleus;spliceosomal complex,protein binding;RNA binding,Pf01423,6633,ENSG00000125743.10,SNRPD2,19,Spliceosome,mRNA Processing,snRNP Assembly; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway,9,High,1
Q9H267,Vacuolar protein sorting-associated protein 33B OS=Homo sapiens OX=9606 GN=VPS33B PE=1 SV=2,0,41.123,17,10,33,10,617,70.5,6.71,12585,0,10,1,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;endosome;Golgi;membrane;vacuole,protein binding,Pf00995,26276,ENSG00000184056.14,VPS33B,15,,,,0,High,1
Q7Z7L7,Protein zer-1 homolog OS=Homo sapiens OX=9606 GN=ZER1 PE=1 SV=1,0,41.11,13,8,34,8,766,88.1,5.62,12691,12.22,7,1,metabolic process;regulation of biological process,,catalytic activity;protein binding,,10444,ENSG00000160445.10,ZER1,9,,,,0,High,1
Q8IYB3,Serine/arginine repetitive matrix protein 1 OS=Homo sapiens OX=9606 GN=SRRM1 PE=1 SV=2,0,41.08,12,7,40,7,904,102.3,11.84,13937,,7,,metabolic process;transport,cytosol;nucleus;spliceosomal complex,DNA binding;protein binding;RNA binding,Pf01480,10250,ENSG00000133226.16,SRRM1,1,mRNA surveillance pathway; RNA transport,mRNA Processing,Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway,14,High,1
Q9BPY3,Protein FAM118B OS=Homo sapiens OX=9606 GN=FAM118B PE=1 SV=1,0,41.063,23,5,24,5,351,39.5,5.99,8161,,5,,cell organization and biogenesis,nucleus,protein binding,Pf13289,79607,ENSG00000197798.8,FAM118B,11,,,,0,High,1
Q96LW7-2,Isoform 2 of Caspase recruitment domain-containing protein 19 OS=Homo sapiens OX=9606 GN=CARD19,0,41.054,25,5,84,5,183,20.6,8.1,28681,43.44,4,1,regulation of biological process,cytosol;membrane;mitochondrion;nucleus,protein binding,Pf00619,84270,ENSG00000165233.17,C9orf89; CARD19,9,,,,0,High,1
Q8WV74,Nucleoside diphosphate-linked moiety X motif 8 OS=Homo sapiens OX=9606 GN=NUDT8 PE=1 SV=2,0,41.013,23,5,66,5,236,25.4,8.41,29927,,5,,,,catalytic activity;metal ion binding,Pf00293,254552,ENSG00000167799.9,NUDT8,11,,,,0,High,1
P62854,40S ribosomal protein S26 OS=Homo sapiens OX=9606 GN=RPS26 PE=1 SV=3,0,41.011,34,3,223,3,115,13,11,89881,,3,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytosol;membrane;ribosome,protein binding;RNA binding;structural molecule activity,Pf01283,6231; 101929876; 728937,ENSG00000197728.9,RPS26; LOC101929876; RPS26P25,12; 20; 4,Ribosome,Cytoplasmic Ribosomal Proteins,"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane",38,High,1
Q96D46,60S ribosomal export protein NMD3 OS=Homo sapiens OX=9606 GN=NMD3 PE=1 SV=1,0,41,20,8,26,8,503,57.6,7.14,9282,,8,,regulation of biological process;transport,cytoplasm;membrane;nucleus,protein binding;RNA binding,Pf04981,51068,ENSG00000169251.12,NMD3,3,Ribosome biogenesis in eukaryotes; RNA transport,,,2,High,1
Q9Y3B3,Transmembrane emp24 domain-containing protein 7 OS=Homo sapiens OX=9606 GN=TMED7 PE=1 SV=2,0,40.976,28,7,51,7,224,25.2,6.89,24488,0,7,2,transport,endoplasmic reticulum;Golgi;membrane,,Pf01105,51014; 100302736,ENSG00000134970.13,TMED7; TMED7-TICAM2,5,,Regulation of toll-like receptor signaling pathway,COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport,12,High,1
P15151,Poliovirus receptor OS=Homo sapiens OX=9606 GN=PVR PE=1 SV=2,0,40.973,12,5,89,5,417,45.3,6.52,45906,,5,,cell organization and biogenesis;regulation of biological process,cell surface;cytoplasm;extracellular;membrane,protein binding;receptor activity,"Pf00047, Pf08205",5817,,PVR,19,Cell adhesion molecules (CAMs),,Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Nectin/Necl  trans heterodimerization,9,High,1
Q8N4V1,Membrane magnesium transporter 1 OS=Homo sapiens OX=9606 GN=MMGT1 PE=1 SV=1,0,40.948,50,4,54,4,131,14.7,9.16,25172,,4,,transport,endoplasmic reticulum;endosome;Golgi;membrane,transporter activity,Pf10270,93380,ENSG00000169446.5,MMGT1,X,,,Miscellaneous transport and binding events,2,High,1
Q8TBP6,Solute carrier family 25 member 40 OS=Homo sapiens OX=9606 GN=SLC25A40 PE=1 SV=1,0,40.946,28,8,37,8,338,38.1,9.35,14775,0,8,1,transport,membrane;mitochondrion,transporter activity,Pf00153,55972,ENSG00000075303.12,SLC25A40,7,,,,0,High,1
Q7Z478,ATP-dependent RNA helicase DHX29 OS=Homo sapiens OX=9606 GN=DHX29 PE=1 SV=2,0,40.879,11,10,25,10,1369,155.1,8.09,9443,,10,,metabolic process,cytoplasm;mitochondrion,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00270, Pf00271, Pf04408, Pf07717",54505,ENSG00000067248.9,DHX29,5,,,,0,High,1
Q15287,RNA-binding protein with serine-rich domain 1 OS=Homo sapiens OX=9606 GN=RNPS1 PE=1 SV=1,0,40.845,23,6,27,6,305,34.2,11.84,13209,,6,,metabolic process;regulation of biological process;transport,cytoplasm;cytosol;nucleus,protein binding;RNA binding,"Pf00076, Pf08777, Pf11608, Pf13893, Pf14259",10921,ENSG00000205937.11,RNPS1,16,RNA transport; mRNA surveillance pathway,mRNA Processing,mRNA 3'-end processing; mRNA Splicing - Major Pathway; Cleavage of Growing Transcript in the Termination Region ; Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC),20,High,1
P16401,Histone H1.5 OS=Homo sapiens OX=9606 GN=H1-5 PE=1 SV=3,0,40.837,21,7,102,4,226,22.6,10.92,45419,0,7,1,cell organization and biogenesis;regulation of biological process,chromosome;nucleus,DNA binding;protein binding;RNA binding,Pf00538,3009,ENSG00000184357.4,HIST1H1B,6,,,Formation of Senescence-Associated Heterochromatin Foci (SAHF); Activation of DNA fragmentation factor,10,High,1
P51571,Translocon-associated protein subunit delta OS=Homo sapiens OX=9606 GN=SSR4 PE=1 SV=1,0,40.823,31,4,59,4,173,19,6.15,25319,,4,,,endoplasmic reticulum;membrane,,Pf05404,6748,ENSG00000180879.13,SSR4,X,Protein processing in endoplasmic reticulum,,SRP-dependent cotranslational protein targeting to membrane,4,High,1
Q9P035,Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 OS=Homo sapiens OX=9606 GN=HACD3 PE=1 SV=2,0,40.817,30,8,47,8,362,43.1,8.94,17895,,8,,metabolic process;regulation of biological process;response to stimulus,cytosol;endoplasmic reticulum;membrane;mitochondrion,catalytic activity;enzyme regulator activity;protein binding,"Pf04387, Pf04969",51495,ENSG00000074696.12,PTPLAD1; HACD3,15,Biosynthesis of unsaturated fatty acids; Fatty acid metabolism; Fatty acid elongation,,Synthesis of very long-chain fatty acyl-CoAs,8,High,1
P30613,Pyruvate kinase PKLR OS=Homo sapiens OX=9606 GN=PKLR PE=1 SV=2,0,40.815,15,8,124,5,574,61.8,7.74,72172,0,8,1,metabolic process;response to stimulus,cytoplasm;cytosol,catalytic activity;metal ion binding;nucleotide binding,"Pf00224, Pf02887",5313,ENSG00000143627.17; ENSG00000262785.5,PKLR,1; CHR_HSCHR1_2_CTG31,Type II diabetes mellitus; Carbon metabolism; Non-alcoholic fatty liver disease (NAFLD); Pyruvate metabolism; Glycolysis / Gluconeogenesis; Maturity onset diabetes of the young; Purine metabolism; Metabolic pathways; Insulin signaling pathway; Biosynthesis of amino acids,Glycolysis and Gluconeogenesis,ChREBP activates metabolic gene expression; Glycolysis,17,High,1
Q8IWL3,Iron-sulfur cluster co-chaperone protein HscB OS=Homo sapiens OX=9606 GN=HSCB PE=1 SV=3,0,40.781,29,6,55,6,235,27.4,7.69,25495,,6,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;mitochondrion;nucleus,enzyme regulator activity;metal ion binding;protein binding,"Pf00226, Pf07743",150274,ENSG00000100209.9,HSCB,22,,,Mitochondrial protein import; Metabolism of proteins; Mitochondrial iron-sulfur cluster biogenesis,4,High,1
P31947,14-3-3 protein sigma OS=Homo sapiens OX=9606 GN=SFN PE=1 SV=1,0,40.764,10,4,713,1,248,27.8,4.74,385726,0,4,1,cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytosol;extracellular;membrane;mitochondrion;nucleus,enzyme regulator activity;protein binding,Pf00244,2810,ENSG00000175793.11,SFN,1,p53 signaling pathway; Cell cycle; Aldosterone-regulated sodium reabsorption,miRNA Regulation of DNA Damage Response; Myometrial Relaxation and Contraction Pathways; Calcium Regulation in the Cardiac Cell; DNA Damage Response,Translocation of GLUT4 to the plasma membrane; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; TP53 Regulates Metabolic Genes; Activation of BAD and translocation to mitochondria ; RHO GTPases activate PKNs,31,High,1
O15305,Phosphomannomutase 2 OS=Homo sapiens OX=9606 GN=PMM2 PE=1 SV=1,0,40.753,35,8,31,8,246,28.1,6.77,13977,,8,,metabolic process;transport,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,"Pf03332, Pf08282",5373,ENSG00000140650.11,PMM2,16,Metabolic pathways; Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism,,Defective PMM2 causes PMM2-CDG (CDG-1a); Synthesis of GDP-mannose,13,High,1
Q9BRF8,Serine/threonine-protein phosphatase CPPED1 OS=Homo sapiens OX=9606 GN=CPPED1 PE=1 SV=3,0,40.722,24,7,52,7,314,35.5,6.2,27315,,7,,metabolic process;transport,cytoplasm;cytosol;extracellular;membrane;organelle lumen,catalytic activity;metal ion binding,Pf00149,55313,ENSG00000103381.11,CPPED1,16,,,Neutrophil degranulation,3,High,1
Q9Y5P4,Ceramide transfer protein OS=Homo sapiens OX=9606 GN=CERT PE=1 SV=1,0,40.691,16,9,36,9,624,70.8,5.48,12947,,9,,cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;Golgi;membrane;mitochondrion,catalytic activity;protein binding,"Pf00169, Pf01852, Pf15409, Pf15413",10087,ENSG00000113163.15,COL4A3BP,5,,,,0,High,1
Q12981,Vesicle transport protein SEC20 OS=Homo sapiens OX=9606 GN=BNIP1 PE=1 SV=3,0,40.676,43,8,34,8,228,26.1,8.95,13713,,8,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;endoplasmic reticulum;membrane;mitochondrion,protein binding,Pf03908,662,ENSG00000113734.17,BNIP1,5,SNARE interactions in vesicular transport,,COPI-dependent Golgi-to-ER retrograde traffic,6,High,1
P11802,Cyclin-dependent kinase 4 OS=Homo sapiens OX=9606 GN=CDK4 PE=1 SV=2,0,40.673,27,6,44,5,303,33.7,7.01,18397,,6,,cell division;cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;cytosol;membrane;nucleus,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding,"Pf00069, Pf01636, Pf07714",1019,ENSG00000135446.16,CDK4,12,Non-small cell lung cancer; Cell cycle; Hepatitis B; Measles; Viral carcinogenesis; Melanoma; Pathways in cancer; Endocrine resistance; Chronic myeloid leukemia; Small cell lung cancer; Tight junction; HTLV-I infection; Glioma; PI3K-Akt signaling pathway; Bladder cancer; p53 signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Breast cancer; Pancreatic cancer; T cell receptor signaling pathway,miRNA Regulation of DNA Damage Response; Cell Cycle; Human Thyroid Stimulating Hormone (TSH) signaling pathway; Signaling Pathways in Glioblastoma; Spinal Cord Injury; Retinoblastoma (RB) in Cancer; Bladder Cancer; PPAR Alpha Pathway; Ovarian Infertility Genes; T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection; H19 action Rb-E2F1 signaling and CDK-beta-catenin activity; G1 to S cell cycle control; DNA Damage Response,Transcriptional regulation of white adipocyte differentiation; RMTs methylate histone arginines; Ubiquitin-dependent degradation of Cyclin D1; Cyclin D associated events in G1; SCF(Skp2)-mediated degradation of p27/p21; Meiotic recombination; PTK6 Regulates Cell Cycle; Oncogene Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Transcriptional regulation by RUNX2; Oxidative Stress Induced Senescence,67,High,1
Q13151,Heterogeneous nuclear ribonucleoprotein A0 OS=Homo sapiens OX=9606 GN=HNRNPA0 PE=1 SV=1,0,40.671,17,4,53,4,305,30.8,9.29,23606,,4,,defense response;metabolic process;regulation of biological process;response to stimulus,nucleus,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",10949,ENSG00000177733.6,HNRNPA0,5,,,mRNA Splicing - Major Pathway,4,High,1
P61962,DDB1- and CUL4-associated factor 7 OS=Homo sapiens OX=9606 GN=DCAF7 PE=1 SV=1,0,40.649,27,7,34,7,342,38.9,5.52,12671,0,7,1,development;metabolic process,cytoplasm;cytosol;nucleus,protein binding,Pf00400,10238,ENSG00000136485.14,DCAF7,17,,,Association of TriC/CCT with target proteins during biosynthesis; Neddylation,6,High,1
P31321,cAMP-dependent protein kinase type I-beta regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR1B PE=1 SV=4,0,40.628,19,6,490,4,381,43,5.71,209292,0,6,1,coagulation;metabolic process;regulation of biological process;response to stimulus,cytosol;membrane,enzyme regulator activity;nucleotide binding;protein binding,"Pf00027, Pf02197",5575,ENSG00000188191.14,PRKAR1B,7,Insulin signaling pathway,miRs in Muscle Cell Differentiation; Myometrial Relaxation and Contraction Pathways; G Protein Signaling Pathways; Calcium Regulation in the Cardiac Cell; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,Signaling by GPCR; PKA activation in glucagon signalling; PKA activation; DARPP-32 events; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Hedgehog 'off' state; Vasopressin regulates renal water homeostasis via Aquaporins; Factors involved in megakaryocyte development and platelet production,32,High,1
Q9Y2W2,WW domain-binding protein 11 OS=Homo sapiens OX=9606 GN=WBP11 PE=1 SV=1,0,40.578,11,8,39,7,641,70,8.38,14037,,8,,metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus;spliceosomal complex,DNA binding;enzyme regulator activity;protein binding;RNA binding,Pf09429,51729,ENSG00000084463.7,WBP11,12,Spliceosome,,mRNA Splicing - Major Pathway,5,High,1
Q9H300,"Presenilins-associated rhomboid-like protein, mitochondrial OS=Homo sapiens OX=9606 GN=PARL PE=1 SV=2",0,40.575,16,6,78,6,379,42.2,9.79,31654,0,6,1,metabolic process;regulation of biological process;transport,membrane;mitochondrion;nucleus,catalytic activity;protein binding,Pf01694,55486,ENSG00000175193.13,PARL,3,,,Processing of SMDT1,3,High,1
O95340,Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 OS=Homo sapiens OX=9606 GN=PAPSS2 PE=1 SV=2,0,40.545,14,6,14,6,614,69.5,8.03,5812,,6,,coagulation;metabolic process,cytosol,catalytic activity;nucleotide binding,"Pf01583, Pf01747, Pf13207, Pf13238, Pf13671, Pf14306",9060,ENSG00000198682.12,PAPSS2,10,Metabolic pathways; Purine metabolism; Selenocompound metabolism; Sulfur metabolism,RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; Sulfation Biotransformation Reaction,Transport and synthesis of PAPS; Defective PAPSS2 causes SEMD-PA; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se,20,High,1
Q8N2S1,Latent-transforming growth factor beta-binding protein 4 OS=Homo sapiens OX=9606 GN=LTBP4 PE=1 SV=2,0,40.513,8,8,40,8,1624,173.3,5.43,14834,,8,,development;metabolic process;regulation of biological process;response to stimulus;transport,extracellular,catalytic activity;metal ion binding;protein binding;receptor activity;signal transducer activity,"Pf00683, Pf07645, Pf12662, Pf12947",8425,ENSG00000090006.17,LTBP4,19,,,Molecules associated with elastic fibres,3,High,1
Q8NBQ5,Estradiol 17-beta-dehydrogenase 11 OS=Homo sapiens OX=9606 GN=HSD17B11 PE=1 SV=3,0,40.474,26,6,25,6,300,32.9,9.07,11109,,6,,metabolic process,cytoplasm;cytosol;extracellular,catalytic activity,"Pf00106, Pf03435, Pf08659, Pf13561",51170,,HSD17B11,4,,,Estrogen biosynthesis,5,High,1
Q9H0U3,Magnesium transporter protein 1 OS=Homo sapiens OX=9606 GN=MAGT1 PE=1 SV=1,0,40.435,16,5,52,5,335,38,9.63,21299,0,5,1,metabolic process;transport,endoplasmic reticulum;membrane,catalytic activity;transporter activity,Pf04756,84061,ENSG00000102158.19,MAGT1,X,,,Asparagine N-linked glycosylation; Neutrophil degranulation; Miscellaneous transport and binding events,8,High,1
Q8IVM0,Coiled-coil domain-containing protein 50 OS=Homo sapiens OX=9606 GN=CCDC50 PE=1 SV=1,0,40.428,28,7,52,7,306,35.8,6.65,21483,,7,,,cytoplasm;cytosol,protein binding,Pf15295,152137,ENSG00000152492.13,CCDC50,3,,,,0,High,1
Q96J42,Thioredoxin domain-containing protein 15 OS=Homo sapiens OX=9606 GN=TXNDC15 PE=1 SV=1,0,40.409,14,3,53,3,360,39.9,4.83,25873,,3,,cellular homeostasis;regulation of biological process,membrane,,Pf00085,79770,ENSG00000113621.14,TXNDC15,5,,,,0,High,1
P62760,Visinin-like protein 1 OS=Homo sapiens OX=9606 GN=VSNL1 PE=1 SV=2,0,40.408,35,6,41,6,191,22.1,5.15,19830,1.75,6,1,regulation of biological process,cytosol;membrane,metal ion binding;protein binding,"Pf00036, Pf13202, Pf13405, Pf13499, Pf13833",7447,ENSG00000163032.11,VSNL1,2,,,,0,High,1
Q7L3B6,Hsp90 co-chaperone Cdc37-like 1 OS=Homo sapiens OX=9606 GN=CDC37L1 PE=1 SV=1,0,40.353,26,7,50,7,337,38.8,5.34,20495,,7,,metabolic process;regulation of biological process;transport,cytoplasm;cytosol;extracellular;organelle lumen,protein binding,Pf08565,55664,ENSG00000106993.11,CDC37L1,9,,,Platelet degranulation,4,High,1
Q6ZMI0,Protein phosphatase 1 regulatory subunit 21 OS=Homo sapiens OX=9606 GN=PPP1R21 PE=1 SV=1,0,40.348,15,9,23,9,780,88.3,6.84,9921,,9,,,membrane,protein binding,"Pf10205, Pf10212",129285,ENSG00000162869.15,PPP1R21,2,,,,0,High,1
P06703,Protein S100-A6 OS=Homo sapiens OX=9606 GN=S100A6 PE=1 SV=1,0,40.301,44,5,161,5,90,10.2,5.48,78066,0,5,1,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;membrane;nucleus,metal ion binding;protein binding;transporter activity,Pf01023,6277,ENSG00000197956.9,S100A6,1,,Gastric cancer network 2; Prostaglandin Synthesis and Regulation,,2,High,1
Q9BRX2,Protein pelota homolog OS=Homo sapiens OX=9606 GN=PELO PE=1 SV=2,0,40.298,19,6,47,6,385,43.3,6.34,21419,,6,,cell division;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process,cytoplasm;nucleus,catalytic activity;metal ion binding;protein binding,"Pf03463, Pf03464, Pf03465",53918,ENSG00000152684.10,PELO,5,mRNA surveillance pathway,Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,,3,High,1
P48454,Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform OS=Homo sapiens OX=9606 GN=PPP3CC PE=1 SV=3,0,40.294,18,9,39,7,512,58.1,6.98,15735,,9,,metabolic process;regulation of biological process,cytosol;mitochondrion,catalytic activity;metal ion binding;protein binding,Pf00149,5533,ENSG00000120910.14,PPP3CC,8,MAPK signaling pathway; Amphetamine addiction; Axon guidance; Th1 and Th2 cell differentiation; Wnt signaling pathway; Natural killer cell mediated cytotoxicity; B cell receptor signaling pathway; Osteoclast differentiation; Oocyte meiosis; Glucagon signaling pathway; cGMP-PKG signaling pathway; Calcium signaling pathway; Long-term potentiation; Glutamatergic synapse; Amyotrophic lateral sclerosis (ALS); Oxytocin signaling pathway; T cell receptor signaling pathway; Alzheimer's disease; VEGF signaling pathway; Dopaminergic synapse; HTLV-I infection; Renin secretion; Tuberculosis,Energy Metabolism; Alzheimers Disease; Amyotrophic lateral sclerosis (ALS); Initiation of transcription and translation elongation at the HIV-1 LTR; G Protein Signaling Pathways; MAPK Signaling Pathway,Signaling by GPCR; DARPP-32 events; Activation of BAD and translocation to mitochondria,38,High,1
P61086,Ubiquitin-conjugating enzyme E2 K OS=Homo sapiens OX=9606 GN=UBE2K PE=1 SV=3,0,40.274,31,6,71,6,200,22.4,5.44,36592,,6,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00179, Pf00627",3093,ENSG00000078140.13,UBE2K,4,Ubiquitin mediated proteolysis,,Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; Negative regulators of DDX58/IFIH1 signaling,12,High,1
Q86Y46,"Keratin, type II cytoskeletal 73 OS=Homo sapiens OX=9606 GN=KRT73 PE=1 SV=1",0,40.231,11,8,243,4,540,58.9,7.23,128214,,8,,cell death,cytosol;nucleus,catalytic activity;motor activity;protein binding;structural molecule activity,"Pf00038, Pf01576, Pf03961, Pf05622, Pf06548, Pf08614, Pf09726, Pf09728, Pf12128",319101,ENSG00000186049.8,KRT73,12,,,Formation of the cornified envelope,3,High,1
P11166,"Solute carrier family 2, facilitated glucose transporter member 1 OS=Homo sapiens OX=9606 GN=SLC2A1 PE=1 SV=2",0,40.169,12,5,69,5,492,54,8.72,31073,0,5,1,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,protein binding;transporter activity,"Pf00083, Pf07690, Pf13347",6513,ENSG00000117394.20,SLC2A1,1,HTLV-I infection; Thyroid hormone signaling pathway; Renal cell carcinoma; Bile secretion; Insulin resistance; HIF-1 signaling pathway; Glucagon signaling pathway; Insulin secretion; Pathways in cancer; Adipocytokine signaling pathway; Central carbon metabolism in cancer,Cori Cycle; NRF2 pathway; Photodynamic therapy-induced HIF-1 survival signaling; Angiopoietin Like Protein 8 Regulatory Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Insulin Signaling; Glycolysis and Gluconeogenesis,Lactose synthesis; Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1); Cellular hexose transport; Regulation of insulin secretion; Vitamin C (ascorbate) metabolism,33,High,1
Q99523,Sortilin OS=Homo sapiens OX=9606 GN=SORT1 PE=1 SV=3,0,40.116,11,6,35,6,831,92,5.74,17770,,6,,cell differentiation;cell organization and biogenesis;development;regulation of biological process;response to stimulus;transport,cell surface;cytosol;endoplasmic reticulum;endosome;Golgi;membrane;nucleus;vacuole,protein binding;receptor activity;signal transducer activity,,6272,ENSG00000134243.11,SORT1,1,Lysosome; Neurotrophin signaling pathway,Brain-Derived Neurotrophic Factor (BDNF) signaling pathway,Golgi Associated Vesicle Biogenesis,8,High,1
O60925,Prefoldin subunit 1 OS=Homo sapiens OX=9606 GN=PFDN1 PE=1 SV=2,0,40.098,37,5,64,5,122,14.2,6.81,31587,,5,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm,protein binding,Pf01920,5201,ENSG00000113068.9,PFDN1,5,,,Prefoldin mediated transfer of substrate  to CCT/TriC,5,High,1
Q9NUL7,Probable ATP-dependent RNA helicase DDX28 OS=Homo sapiens OX=9606 GN=DDX28 PE=1 SV=2,0,40.097,24,9,36,9,540,59.5,10.42,13452,,9,,cell organization and biogenesis;metabolic process,cytosol;mitochondrion;nucleus;organelle lumen,catalytic activity;nucleotide binding;RNA binding,"Pf00270, Pf00271",55794,ENSG00000182810.6,DDX28,16,,,,0,High,1
P62253,Ubiquitin-conjugating enzyme E2 G1 OS=Homo sapiens OX=9606 GN=UBE2G1 PE=1 SV=3,0,40.086,53,7,57,7,170,19.5,5.3,23876,,7,,metabolic process,cytoplasm;cytosol,catalytic activity;nucleotide binding;protein binding,Pf00179,7326,ENSG00000132388.12,UBE2G1,17,Parkinson's disease; Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum,Parkin-Ubiquitin Proteasomal System pathway; Parkinsons Disease Pathway,Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation,13,High,1
Q8N490-2,Isoform 2 of Probable hydrolase PNKD OS=Homo sapiens OX=9606 GN=PNKD,0,40.067,38,5,46,5,142,15.4,10.58,20713,17.3,3,2,metabolic process;regulation of biological process,membrane;mitochondrion;nucleus,catalytic activity;metal ion binding;protein binding,,25953,ENSG00000127838.13,PNKD,2,,,,0,High,1
O00506,Serine/threonine-protein kinase 25 OS=Homo sapiens OX=9606 GN=STK25 PE=1 SV=1,0,40.045,17,7,57,2,426,48.1,6.74,24902,,7,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;Golgi;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf06840, Pf07714",10494,ENSG00000115694.14,STK25,2,,,,0,High,1
Q86TI0,TBC1 domain family member 1 OS=Homo sapiens OX=9606 GN=TBC1D1 PE=1 SV=2,0,39.997,7,7,54,7,1168,133,6.96,24351,,7,,cell organization and biogenesis;regulation of biological process;transport,cytosol;nucleus,enzyme regulator activity;protein binding,"Pf00566, Pf00640, Pf11830",23216,ENSG00000065882.15,TBC1D1,4,AMPK signaling pathway,Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,Translocation of GLUT4 to the plasma membrane,5,High,1
Q15843,NEDD8 OS=Homo sapiens OX=9606 GN=NEDD8 PE=1 SV=1,0,39.958,42,5,50,5,81,9.1,8.43,26873,0,5,1,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cytosol;nucleus,protein binding,"Pf00240, Pf11976",4738,ENSG00000129559.12,NEDD8,14,,EGF/EGFR Signaling Pathway,Cargo recognition for clathrin-mediated endocytosis; UCH proteinases; TGF-beta receptor signaling activates SMADs; Iron uptake and transport; Neddylation,16,High,1
Q16854,"Deoxyguanosine kinase, mitochondrial OS=Homo sapiens OX=9606 GN=DGUOK PE=1 SV=2",0,39.955,25,5,64,5,277,32,8.66,25210,,5,,metabolic process;regulation of biological process,cytoplasm;cytosol;mitochondrion;nucleus;organelle lumen,catalytic activity;nucleotide binding,"Pf01712, Pf13238",1716,ENSG00000114956.19,DGUOK,2,Metabolic pathways; Purine metabolism,,Purine salvage,6,High,1
Q9UBI1,COMM domain-containing protein 3 OS=Homo sapiens OX=9606 GN=COMMD3 PE=1 SV=1,0,39.953,38,6,56,6,195,22.1,5.99,27023,,6,,metabolic process;regulation of biological process;transport,cytoplasm;extracellular;nucleus,protein binding,Pf07258,23412,ENSG00000148444.15,COMMD3,10,,,Neutrophil degranulation; Neddylation,6,High,1
Q9NWV8,BRISC and BRCA1-A complex member 1 OS=Homo sapiens OX=9606 GN=BABAM1 PE=1 SV=1,0,39.892,27,6,38,6,329,36.5,4.64,18847,,6,,cell division;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,protein binding,,29086,ENSG00000105393.15,BABAM1,19,Homologous recombination,,G2/M DNA damage checkpoint; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; Nonhomologous End-Joining (NHEJ); Metalloprotease DUBs,17,High,1
Q6P1L8,"39S ribosomal protein L14, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL14 PE=1 SV=1",0,39.834,41,5,53,5,145,15.9,10.24,25591,,5,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,RNA binding;structural molecule activity,Pf00238,64928,ENSG00000180992.6,MRPL14,6,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
Q9NXC5,GATOR complex protein MIOS OS=Homo sapiens OX=9606 GN=MIOS PE=1 SV=2,0,39.807,12,10,34,9,875,98.5,6.73,13096,,10,,cell communication;regulation of biological process;response to stimulus,membrane;vacuole,protein binding,,54468,ENSG00000164654.15,MIOS,7,mTOR signaling pathway,,,1,High,1
P16070-8,Isoform 8 of CD44 antigen OS=Homo sapiens OX=9606 GN=CD44,0,39.702,15,6,41,6,674,74.3,5.2,17601,0,5,2,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytosol;Golgi;membrane,protein binding;receptor activity;signal transducer activity,Pf00193,960,,CD44,11,,Hepatitis C and Hepatocellular Carcinoma; Wnt Signaling Pathway and Pluripotency; Senescence and Autophagy in Cancer,,3,High,1
A1L4K1,Fibronectin type III and SPRY domain-containing protein 2 OS=Homo sapiens OX=9606 GN=FSD2 PE=1 SV=1,0,39.695,12,7,30,7,749,85.3,4.89,,60.79,,7,,,protein binding,"Pf00041, Pf00622, Pf02010, Pf13765",123722,ENSG00000186628.12,FSD2,15,,,,0,High,1
P62913,60S ribosomal protein L11 OS=Homo sapiens OX=9606 GN=RPL11 PE=1 SV=2,0,39.681,24,4,133,4,178,20.2,9.6,62135,,4,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;membrane;nucleus;ribosome,protein binding;RNA binding;structural molecule activity,"Pf00281, Pf00673",6135,ENSG00000142676.12,RPL11,1,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
A6NNS2,Dehydrogenase/reductase SDR family member 7C OS=Homo sapiens OX=9606 GN=DHRS7C PE=2 SV=3,0,39.647,29,6,42,6,312,34.9,8.47,5470,59.25,1,5,metabolic process;regulation of biological process,extracellular;membrane,catalytic activity,"Pf00106, Pf13561",201140,ENSG00000184544.11,DHRS7C,17,,,,0,High,1
Q14693,Phosphatidate phosphatase LPIN1 OS=Homo sapiens OX=9606 GN=LPIN1 PE=1 SV=2,0,39.637,11,7,27,7,890,98.6,6.58,12211,,7,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus,catalytic activity,"Pf04571, Pf08235, Pf15017",23175,ENSG00000134324.11,LPIN1,2,Glycerophospholipid metabolism; Glycerolipid metabolism; Metabolic pathways; mTOR signaling pathway,Sterol Regulatory Element-Binding Proteins (SREBP) signalling; Adipogenesis; Transcription factor regulation in adipogenesis,Synthesis of PC; Depolymerisation of the Nuclear Lamina; Triglyceride biosynthesis; Synthesis of PE,21,High,1
O75170,Serine/threonine-protein phosphatase 6 regulatory subunit 2 OS=Homo sapiens OX=9606 GN=PPP6R2 PE=1 SV=2,0,39.58,12,7,33,7,966,104.9,4.87,12540,,7,,,cytoplasm;cytosol,protein binding,Pf04499,9701,ENSG00000100239.15,PPP6R2,22,,,,0,High,1
Q13442,28 kDa heat- and acid-stable phosphoprotein OS=Homo sapiens OX=9606 GN=PDAP1 PE=1 SV=1,0,39.573,31,5,49,5,181,20.6,8.87,22018,,5,,cell proliferation;regulation of biological process;response to stimulus;transport,extracellular,RNA binding,Pf10252,11333,ENSG00000106244.12,PDAP1,7,,,Neutrophil degranulation,3,High,1
Q7Z7H5,Transmembrane emp24 domain-containing protein 4 OS=Homo sapiens OX=9606 GN=TMED4 PE=1 SV=1,0,39.534,31,6,83,5,227,25.9,8.28,35246,,6,,regulation of biological process;response to stimulus;transport,endoplasmic reticulum;membrane,signal transducer activity,Pf01105,222068,ENSG00000158604.14,TMED4,7,,,,0,High,1
P63172,Dynein light chain Tctex-type 1 OS=Homo sapiens OX=9606 GN=DYNLT1 PE=1 SV=1,0,39.477,30,3,36,3,113,12.4,5.08,15695,2.59,3,1,cell division;cell organization and biogenesis;cellular component movement;regulation of biological process;transport,cytoplasm;cytoskeleton;extracellular;Golgi;mitochondrion;organelle lumen,catalytic activity;motor activity;protein binding,Pf03645,6993,ENSG00000146425.10,DYNLT1,6,,,Neutrophil degranulation,3,High,1
Q9Y2L1,Exosome complex exonuclease RRP44 OS=Homo sapiens OX=9606 GN=DIS3 PE=1 SV=2,0,39.431,11,9,43,8,958,108.9,7.14,18492,,9,,metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;nucleus,catalytic activity;protein binding;RNA binding,"Pf00773, Pf09742, Pf13638",22894,ENSG00000083520.14,DIS3,13,RNA degradation,,"Major pathway of rRNA processing in the nucleolus and cytosol; mRNA decay by 3' to 5' exoribonuclease; ATF4 activates genes; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; KSRP (KHSRP) binds and destabilizes mRNA",15,High,1
O00399,Dynactin subunit 6 OS=Homo sapiens OX=9606 GN=DCTN6 PE=1 SV=1,0,39.43,19,5,108,5,190,20.7,6.32,51300,,5,,transport,chromosome;cytoplasm;cytoskeleton;cytosol,,,10671,ENSG00000104671.7,DCTN6,8,Vasopressin-regulated water reabsorption,,COPI-independent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR),18,High,1
Q96GQ5,RUS1 family protein C16orf58 OS=Homo sapiens OX=9606 GN=C16orf58 PE=1 SV=2,0,39.425,21,8,30,7,468,51,6.93,12116,,8,,,membrane,,Pf04884,64755,ENSG00000140688.16,C16orf58,16,,,,0,High,1
P25398,40S ribosomal protein S12 OS=Homo sapiens OX=9606 GN=RPS12 PE=1 SV=3,0,39.423,30,5,58,5,132,14.5,7.21,28694,,5,,cell organization and biogenesis;metabolic process;transport,cytoplasm;cytosol;membrane;ribosome,RNA binding;structural molecule activity,Pf01248,6206,ENSG00000112306.7,RPS12,6,Ribosome,Cytoplasmic Ribosomal Proteins,"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane",38,High,1
Q8ND24,RING finger protein 214 OS=Homo sapiens OX=9606 GN=RNF214 PE=1 SV=2,0,39.37,15,8,17,8,703,77.6,6.95,8719,,8,,,,metal ion binding;protein binding,"Pf00097, Pf12678, Pf12906, Pf13639, Pf14634",257160,ENSG00000167257.10,RNF214,11,,,,0,High,1
O00142,"Thymidine kinase 2, mitochondrial OS=Homo sapiens OX=9606 GN=TK2 PE=1 SV=4",0,39.353,28,5,46,5,265,31,8.46,18619,,5,,metabolic process,mitochondrion;organelle lumen,catalytic activity;nucleotide binding,Pf01712,7084,ENSG00000166548.15,TK2,16,Pyrimidine metabolism; Drug metabolism - other enzymes; Metabolic pathways,,Pyrimidine salvage,7,High,1
Q9H307,Pinin OS=Homo sapiens OX=9606 GN=PNN PE=1 SV=5,0,39.334,13,9,42,9,717,81.6,7.14,16759,,9,,,,,,,,,,,,,0,High,1
Q9H8S9,MOB kinase activator 1A OS=Homo sapiens OX=9606 GN=MOB1A PE=1 SV=4,0,39.303,29,6,63,1,216,25.1,6.95,27460,,6,,regulation of biological process;response to stimulus,cytosol;nucleus,metal ion binding;protein binding,Pf03637,55233,ENSG00000114978.17,MOB1A,2,Hippo signaling pathway; Hippo signaling pathway -multiple species,,Signaling by Hippo,4,High,1
Q15102,Platelet-activating factor acetylhydrolase IB subunit gamma OS=Homo sapiens OX=9606 GN=PAFAH1B3 PE=1 SV=1,0,39.241,44,6,27,6,231,25.7,6.84,13032,,6,,metabolic process,cytoplasm;cytosol;membrane,catalytic activity;protein binding,"Pf00657, Pf13472",5050,ENSG00000079462.7,PAFAH1B3,19,Metabolic pathways; Ether lipid metabolism,,COPI-independent Golgi-to-ER retrograde traffic,7,High,1
Q86UY8,5'-nucleotidase domain-containing protein 3 OS=Homo sapiens OX=9606 GN=NT5DC3 PE=1 SV=1,0,39.228,19,7,22,7,548,63.4,8.31,10023,,7,,metabolic process,,catalytic activity;metal ion binding;receptor activity;signal transducer activity,Pf05761,51559,ENSG00000111696.11,NT5DC3,12,,,,0,High,1
P54105,Methylosome subunit pICln OS=Homo sapiens OX=9606 GN=CLNS1A PE=1 SV=1,0,39.227,42,6,21,6,237,26.2,4.11,8540,0,6,1,cell organization and biogenesis;cellular homeostasis;transport,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,protein binding;RNA binding,Pf03517,1207,ENSG00000074201.8,CLNS1A,11,RNA transport,,snRNP Assembly,4,High,1
Q8WVT3,Trafficking protein particle complex subunit 12 OS=Homo sapiens OX=9606 GN=TRAPPC12 PE=1 SV=3,0,39.217,16,7,18,7,735,79.3,4.91,8070,,7,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,chromosome;cytosol;nucleus,catalytic activity;protein binding,"Pf13414, Pf13424, Pf14559",51112,ENSG00000171853.15,TRAPPC12,2,,,RAB GEFs exchange GTP for GDP on RABs,4,High,1
Q8WZ82,Esterase OVCA2 OS=Homo sapiens OX=9606 GN=OVCA2 PE=1 SV=1,0,39.2,31,4,29,4,227,24.4,6.89,14135,,4,,response to stimulus,cytoplasm;nucleus,catalytic activity,Pf03959,124641,ENSG00000262664.2,OVCA2,17,,,,0,High,1
Q9BRT2,Ubiquinol-cytochrome-c reductase complex assembly factor 2 OS=Homo sapiens OX=9606 GN=UQCC2 PE=1 SV=1,0,39.198,32,5,70,5,126,14.9,7.37,38917,,5,,cell organization and biogenesis;regulation of biological process,membrane;mitochondrion;organelle lumen,protein binding,,84300,ENSG00000137288.9,MNF1; UQCC2,6,,,,0,High,1
O14776,Transcription elongation regulator 1 OS=Homo sapiens OX=9606 GN=TCERG1 PE=1 SV=2,0,39.126,9,9,32,9,1098,123.8,8.65,13914,,9,,metabolic process;regulation of biological process,nucleus,protein binding;RNA binding,"Pf00397, Pf01846, Pf13949",10915,ENSG00000113649.11,TCERG1,5,Spliceosome,,,1,High,1
Q12929,Epidermal growth factor receptor kinase substrate 8 OS=Homo sapiens OX=9606 GN=EPS8 PE=1 SV=1,0,39.101,16,8,30,8,822,91.8,7.5,7955,,8,,cell organization and biogenesis;cell proliferation;cellular component movement;regulation of biological process;response to stimulus,cytoplasm;membrane,protein binding,"Pf00018, Pf00640, Pf07653, Pf08416, Pf14604",2059,ENSG00000151491.12,EPS8,12,,EGF/EGFR Signaling Pathway,,1,High,1
Q9NPF4,Probable tRNA N6-adenosine threonylcarbamoyltransferase OS=Homo sapiens OX=9606 GN=OSGEP PE=1 SV=1,0,39.101,32,7,76,7,335,36.4,6.35,29771,,7,,metabolic process,cytoplasm;membrane;nucleus,catalytic activity;metal ion binding;protein binding,Pf00814,55644,ENSG00000092094.10,OSGEP,14,,,tRNA modification in the nucleus and cytosol,3,High,1
Q96GG9,DCN1-like protein 1 OS=Homo sapiens OX=9606 GN=DCUN1D1 PE=1 SV=1,0,39.1,22,5,58,5,259,30.1,5.34,25289,,5,,defense response;metabolic process;regulation of biological process;response to stimulus,cytosol;nucleus,catalytic activity;protein binding,"Pf03556, Pf14555",54165,ENSG00000043093.13,DCUN1D1,3,,,Neddylation,3,High,1
Q96HN2,Adenosylhomocysteinase 3 OS=Homo sapiens OX=9606 GN=AHCYL2 PE=1 SV=1,0,39.035,9,6,64,1,611,66.7,7.36,27721,,6,,metabolic process;transport,cytoplasm;cytosol;endoplasmic reticulum,catalytic activity;nucleotide binding;protein binding,"Pf00670, Pf01262, Pf02254, Pf02826, Pf05221",23382,ENSG00000158467.16,AHCYL2,7,Metabolic pathways; Cysteine and methionine metabolism,One Carbon Metabolism; Trans-sulfuration and one carbon metabolism,Bicarbonate transporters,8,High,1
Q6DHV7,Adenosine deaminase-like protein OS=Homo sapiens OX=9606 GN=ADAL PE=1 SV=2,0,39.027,26,8,40,8,355,40.2,6.32,18781,9.88,7,1,metabolic process,cytosol,catalytic activity;metal ion binding,Pf00962,161823,ENSG00000168803.14,ADAL,15,,,Abacavir metabolism; Purine salvage,6,High,1
Q8IUR7,Armadillo repeat-containing protein 8 OS=Homo sapiens OX=9606 GN=ARMC8 PE=1 SV=2,0,38.994,13,7,35,7,673,75.5,6.73,13740,,7,,transport,extracellular;organelle lumen,protein binding,Pf01602,25852,ENSG00000114098.17,ARMC8,3,,,Neutrophil degranulation,3,High,1
Q9H0X4,Protein FAM234A OS=Homo sapiens OX=9606 GN=FAM234A PE=1 SV=1,0,38.971,17,6,25,6,552,59.6,6.28,10016,,6,,,cell surface;membrane,,,83986,ENSG00000167930.15,ITFG3; FAM234A,16,,,,0,High,1
P61421,V-type proton ATPase subunit d 1 OS=Homo sapiens OX=9606 GN=ATP6V0D1 PE=1 SV=1,0,38.951,23,6,33,6,351,40.3,5,14124,,6,,cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport,endosome;membrane,catalytic activity;protein binding;transporter activity,Pf01992,9114,ENSG00000159720.11,ATP6V0D1,16,Collecting duct acid secretion; Oxidative phosphorylation; Metabolic pathways; Tuberculosis; Synaptic vesicle cycle; Viral carcinogenesis; Epithelial cell signaling in Helicobacter pylori infection; Vibrio cholerae infection; Phagosome; Rheumatoid arthritis; Lysosome,,"Transferrin endocytosis and recycling; ROS, RNS production in phagocytes; Ion channel transport; Insulin receptor recycling; XBP1(S) activates chaperone genes",26,High,1
Q7Z6J6,FERM domain-containing protein 5 OS=Homo sapiens OX=9606 GN=FRMD5 PE=1 SV=1,0,38.887,11,3,14,3,570,65,8.35,4509,21.14,2,2,cell organization and biogenesis;regulation of biological process,cytoskeleton;membrane,protein binding;structural molecule activity,"Pf00373, Pf08736, Pf09379, Pf09380",84978,ENSG00000171877.20,FRMD5,15,,,,0,High,1
Q9P2T1,GMP reductase 2 OS=Homo sapiens OX=9606 GN=GMPR2 PE=1 SV=1,0,38.883,29,7,84,6,348,37.9,7.23,35351,,7,,metabolic process,cytosol,catalytic activity;metal ion binding,"Pf00478, Pf01070",51292,ENSG00000100938.17,GMPR2,14,Purine metabolism,,Purine salvage,5,High,1
Q15427,Splicing factor 3B subunit 4 OS=Homo sapiens OX=9606 GN=SF3B4 PE=1 SV=1,0,38.872,22,6,26,6,424,44.4,8.56,10066,,6,,metabolic process;regulation of biological process,nucleus;spliceosomal complex,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",10262,ENSG00000143368.9,SF3B4,1,Spliceosome,mRNA Processing,mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway,7,High,1
P40429,60S ribosomal protein L13a OS=Homo sapiens OX=9606 GN=RPL13A PE=1 SV=2,0,38.861,24,5,149,5,203,23.6,10.93,75354,,5,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus;ribosome,RNA binding;structural molecule activity,Pf00572,23521,ENSG00000142541.16,RPL13A,19,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
Q9GZT9,Egl nine homolog 1 OS=Homo sapiens OX=9606 GN=EGLN1 PE=1 SV=1,0,38.85,15,6,25,6,426,46,8.53,12681,,6,,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;protein binding,"Pf01753, Pf03171, Pf13640, Pf13661",54583,ENSG00000135766.8,EGLN1,1,HIF-1 signaling pathway; Pathways in cancer; Renal cell carcinoma,Photodynamic therapy-induced HIF-1 survival signaling,Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha,9,High,1
O14735,CDP-diacylglycerol--inositol 3-phosphatidyltransferase OS=Homo sapiens OX=9606 GN=CDIPT PE=1 SV=1,0,38.822,21,4,57,4,213,23.5,8.03,27445,0,4,1,metabolic process,endoplasmic reticulum;Golgi;membrane,catalytic activity;metal ion binding;protein binding,Pf01066,10423,ENSG00000103502.13,CDIPT,16,Glycerophospholipid metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Inositol phosphate metabolism,,Synthesis of PI,9,High,1
Q96FQ6,Protein S100-A16 OS=Homo sapiens OX=9606 GN=S100A16 PE=1 SV=1,0,38.818,35,4,41,4,103,11.8,6.79,18124,0,4,1,response to stimulus,cytoplasm;cytosol;membrane;nucleus,metal ion binding;protein binding;RNA binding,"Pf01023, Pf13202, Pf13499, Pf13833",140576,ENSG00000188643.10,S100A16,1,,,,0,High,1
A6NHR9,Structural maintenance of chromosomes flexible hinge domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SMCHD1 PE=1 SV=2,0,38.814,7,11,31,11,2005,226.2,7.3,11412,,11,,cell organization and biogenesis;regulation of biological process,chromosome,catalytic activity;nucleotide binding;protein binding,"Pf06470, Pf13589",23347,ENSG00000101596.14,SMCHD1,18,,,,0,High,1
Q9H0A8,COMM domain-containing protein 4 OS=Homo sapiens OX=9606 GN=COMMD4 PE=1 SV=1,0,38.802,33,4,42,4,199,21.8,7.31,20230,,4,,metabolic process;regulation of biological process,cytoplasm;nucleus,protein binding,Pf07258,54939,ENSG00000140365.15,COMMD4,15,,,Neddylation,3,High,1
A0A0C4DH38,Immunoglobulin heavy variable 5-51 OS=Homo sapiens OX=9606 GN=IGHV5-51 PE=3 SV=1,0,38.791,54,5,74,5,117,12.7,8.27,34698,,5,,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,protein binding,,28388,ENSG00000277574.2; ENSG00000211966.2,IGHV5-51,14; CHR_HSCHR14_3_CTG1,,,,0,High,1
Q15814,Tubulin-specific chaperone C OS=Homo sapiens OX=9606 GN=TBCC PE=1 SV=2,0,38.778,28,8,34,8,346,39.2,5.71,14194,,8,,cell organization and biogenesis;metabolic process,cytoplasm;cytoskeleton;cytosol,catalytic activity;protein binding,Pf07986,6903,ENSG00000124659.6,TBCC,6,,,Post-chaperonin tubulin folding pathway,3,High,1
P07357,Complement component C8 alpha chain OS=Homo sapiens OX=9606 GN=C8A PE=1 SV=2,0,38.761,15,7,74,7,584,65.1,6.47,34393,,7,,defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,protein binding,"Pf00057, Pf00090, Pf01823",731,ENSG00000157131.10,C8A,1,Amoebiasis; Systemic lupus erythematosus; Prion diseases; Complement and coagulation cascades,Allograft Rejection; Complement Activation,Terminal pathway of complement; Regulation of Complement cascade,11,High,1
Q13049,E3 ubiquitin-protein ligase TRIM32 OS=Homo sapiens OX=9606 GN=TRIM32 PE=1 SV=2,0,38.741,15,8,39,8,653,71.9,6.98,18890,,8,,cell differentiation;cell organization and biogenesis;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;protein binding;RNA binding,"Pf00097, Pf00643, Pf01436, Pf10186, Pf13445, Pf13639, Pf13920, Pf13923, Pf14570, Pf14634, Pf15227",22954,ENSG00000119401.10,TRIM32,9,Ubiquitin mediated proteolysis,,Antigen processing: Ubiquitination & Proteasome degradation; Regulation of innate immune responses to cytosolic DNA,8,High,1
Q14376,UDP-glucose 4-epimerase OS=Homo sapiens OX=9606 GN=GALE PE=1 SV=2,0,38.68,34,7,34,7,348,38.3,6.73,11473,,7,,metabolic process,cytosol,catalytic activity;protein binding,"Pf00106, Pf01073, Pf01370, Pf02719, Pf04321, Pf05368, Pf07993, Pf08659, Pf13460, Pf13950",2582,ENSG00000117308.14,GALE,1,Metabolic pathways; Galactose metabolism; Amino sugar and nucleotide sugar metabolism,,Defective GALE can cause Epimerase-deficiency galactosemia (EDG); Galactose catabolism,10,High,1
P48730,Casein kinase I isoform delta OS=Homo sapiens OX=9606 GN=CSNK1D PE=1 SV=2,0,38.645,29,11,35,3,415,47.3,9.74,12161,,11,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;Golgi;membrane;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf01636, Pf07714",1453,ENSG00000141551.14,CSNK1D,17,Hippo signaling pathway; Circadian rhythm; Gap junction; Hedgehog signaling pathway,Integrated Breast Cancer Pathway; Melatonin metabolism and effects; Wnt Signaling Pathway Netpath,Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; COPII (Coat Protein 2) Mediated Vesicle Transport; Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; Circadian Clock; Major pathway of rRNA processing in the nucleolus and cytosol,36,High,1
P02452,Collagen alpha-1(I) chain OS=Homo sapiens OX=9606 GN=COL1A1 PE=1 SV=5,0,38.636,7,7,73,7,1464,138.9,5.8,32782,,7,,cell communication;cell differentiation;cell organization and biogenesis;cellular component movement;coagulation;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;extracellular;Golgi;organelle lumen,metal ion binding;protein binding;structural molecule activity,"Pf00093, Pf01391, Pf01410",1277,,COL1A1,17,Protein digestion and absorption; Platelet activation; AGE-RAGE signaling pathway in diabetic complications; Focal adhesion; ECM-receptor interaction; Amoebiasis; PI3K-Akt signaling pathway,Focal Adhesion; Osteoblast Signaling; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; miR-509-3p alteration of YAP1/ECM axis; Inflammatory Response Pathway; Senescence and Autophagy in Cancer,Collagen degradation; Integrin cell surface interactions; MET activates PTK2 signaling; Crosslinking of collagen fibrils; Anchoring fibril formation; Platelet Adhesion to exposed collagen; Scavenging by Class A Receptors; Syndecan interactions; GP1b-IX-V activation signalling; ECM proteoglycans; RUNX2 regulates osteoblast differentiation; Platelet Aggregation (Plug Formation); Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Collagen chain trimerization; GPVI-mediated activation cascade; Cell surface interactions at the vascular wall,50,High,1
P98196,Probable phospholipid-transporting ATPase IH OS=Homo sapiens OX=9606 GN=ATP11A PE=1 SV=3,0,38.573,8,7,21,7,1134,129.7,6.6,9602,,7,,cell organization and biogenesis;transport,endoplasmic reticulum;endosome;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding;transporter activity,"Pf00122, Pf00702, Pf08282, Pf13206, Pf13246",23250,ENSG00000068650.18,ATP11A,13,,Lung fibrosis,Neutrophil degranulation; Ion transport by P-type ATPases,7,High,1
Q13242,Serine/arginine-rich splicing factor 9 OS=Homo sapiens OX=9606 GN=SRSF9 PE=1 SV=1,0,38.539,23,7,26,6,221,25.5,8.65,13791,,7,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,nucleus,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",8683,ENSG00000111786.8,SRSF9,12,Herpes simplex infection; Spliceosome,mRNA Processing,Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway,14,High,1
P30536,Translocator protein OS=Homo sapiens OX=9606 GN=TSPO PE=1 SV=3,0,38.536,42,7,97,7,169,18.8,9.36,47583,,7,,cell death;cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,membrane;mitochondrion,protein binding;receptor activity;signal transducer activity;transporter activity,Pf03073,706,ENSG00000100300.17,TSPO,22,HTLV-I infection; Neuroactive ligand-receptor interaction,,Pregnenolone biosynthesis,7,High,1
P53582,Methionine aminopeptidase 1 OS=Homo sapiens OX=9606 GN=METAP1 PE=1 SV=2,0,38.486,24,7,78,7,386,43.2,7.17,32413,,7,,metabolic process;regulation of biological process,cytoplasm;cytosol,catalytic activity;metal ion binding,Pf00557,23173,ENSG00000164024.11,METAP1,4,,,"Signaling by GPCR; Inactivation, recovery and regulation of the phototransduction cascade",5,High,1
O43504,Ragulator complex protein LAMTOR5 OS=Homo sapiens OX=9606 GN=LAMTOR5 PE=1 SV=1,0,38.475,37,2,52,2,91,9.6,4.87,25607,,2,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;vacuole,protein binding;structural molecule activity,,10542,ENSG00000134248.13,LAMTOR5,1,mTOR signaling pathway; Hepatitis B,,Energy dependent regulation of mTOR by LKB1-AMPK; Regulation of PTEN gene transcription; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Macroautophagy,17,High,1
P50914,60S ribosomal protein L14 OS=Homo sapiens OX=9606 GN=RPL14 PE=1 SV=4,0,38.45,11,4,149,4,215,23.4,10.93,68188,0,4,1,cell organization and biogenesis;metabolic process;transport,cytosol;membrane;ribosome,protein binding;RNA binding;structural molecule activity,Pf01929,9045,ENSG00000188846.13,RPL14,3,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
P49356,Protein farnesyltransferase subunit beta OS=Homo sapiens OX=9606 GN=FNTB PE=1 SV=1,0,38.438,19,8,32,8,437,48.7,5.82,15642,,8,,metabolic process;regulation of biological process;response to stimulus,cytosol,catalytic activity;metal ion binding;protein binding,"Pf00432, Pf13243, Pf13249",2342; 100529261,ENSG00000257365.7,FNTB; CHURC1-FNTB,14,Terpenoid backbone biosynthesis,,"Signaling by GPCR; Inactivation, recovery and regulation of the phototransduction cascade",6,High,1
Q9H3F6,BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 OS=Homo sapiens OX=9606 GN=KCTD10 PE=1 SV=1,0,38.427,27,8,42,5,313,35.4,6.34,17263,0,7,1,cell organization and biogenesis;metabolic process;transport,cytosol;nucleus,catalytic activity;protein binding;transporter activity,"Pf00651, Pf02214, Pf09626",83892,ENSG00000110906.12,KCTD10,12,,,,0,High,1
Q99961,Endophilin-A2 OS=Homo sapiens OX=9606 GN=SH3GL1 PE=1 SV=1,0,38.402,18,6,49,3,368,41.5,5.43,23163,0,6,1,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;endosome;membrane,protein binding,"Pf00018, Pf03114, Pf07653, Pf10455, Pf13514, Pf14604",6455,ENSG00000141985.9,SH3GL1,19,Endocytosis,,Cargo recognition for clathrin-mediated endocytosis; Negative regulation of MET activity; EGFR downregulation; InlB-mediated entry of Listeria monocytogenes into host cell,15,High,1
P31025,Lipocalin-1 OS=Homo sapiens OX=9606 GN=LCN1 PE=1 SV=1,0,38.353,51,6,68,6,176,19.2,5.58,27951,1.74,6,1,metabolic process;regulation of biological process;response to stimulus;transport,extracellular,enzyme regulator activity;metal ion binding;protein binding,"Pf00061, Pf04630",3933,ENSG00000160349.9,LCN1,9,,,Transport of fatty acids,4,High,1
Q53HC9,EARP and GARP complex-interacting protein 1 OS=Homo sapiens OX=9606 GN=EIPR1 PE=1 SV=2,0,38.352,24,6,31,6,387,43.6,5.06,12437,0,5,1,,,protein binding,Pf00400,7260,ENSG00000032389.12,TSSC1; EIPR1,2,,,,0,High,1
Q86X55,Histone-arginine methyltransferase CARM1 OS=Homo sapiens OX=9606 GN=CARM1 PE=1 SV=3,0,38.344,17,8,32,8,608,65.8,6.73,15076,,8,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;DNA binding;protein binding,"Pf02475, Pf05175, Pf05185, Pf06325, Pf08003, Pf08241, Pf08242, Pf11531, Pf12847, Pf13649, Pf13659, Pf13847",10498,ENSG00000142453.11,CARM1,19,Endocrine resistance,Androgen receptor signaling pathway,"Transcriptional regulation of white adipocyte differentiation; RMTs methylate histone arginines; Activation of gene expression by SREBF (SREBP); TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; RORA activates gene expression; PPARA activates gene expression; YAP1- and WWTR1 (TAZ)-stimulated gene expression; Transcriptional activation of mitochondrial biogenesis; BMAL1:CLOCK,NPAS2 activates circadian gene expression; RUNX3 regulates YAP1-mediated transcription",29,High,1
Q96N67,Dedicator of cytokinesis protein 7 OS=Homo sapiens OX=9606 GN=DOCK7 PE=1 SV=4,0,38.306,6,9,24,8,2140,242.4,6.8,8253,0,9,1,cell differentiation;cell organization and biogenesis;development;regulation of biological process;response to stimulus,,protein binding,"Pf06920, Pf11878, Pf14429",85440,ENSG00000116641.17,DOCK7,1,,,MET activates RAP1 and RAC1; Factors involved in megakaryocyte development and platelet production,7,High,1
Q9Y5L0-1,Isoform 1 of Transportin-3 OS=Homo sapiens OX=9606 GN=TNPO3,0,38.295,10,7,22,7,957,107.9,5.71,8141,,7,,transport,cytoplasm;membrane,protein binding;receptor activity;transporter activity,Pf08389,23534,,TNPO3,7,,,,0,High,1
Q9H115,Beta-soluble NSF attachment protein OS=Homo sapiens OX=9606 GN=NAPB PE=1 SV=2,0,38.267,12,3,77,1,298,33.5,5.47,37191,,3,,cell organization and biogenesis;transport,membrane,protein binding,Pf14938,63908,ENSG00000125814.17,NAPB,20,,,COPI-dependent Golgi-to-ER retrograde traffic; Intra-Golgi traffic; COPII (Coat Protein 2) Mediated Vesicle Transport; COPI-mediated anterograde transport; Retrograde transport at the Trans-Golgi-Network,14,High,1
Q8IXS6,Paralemmin-2 OS=Homo sapiens OX=9606 GN=PALM2 PE=1 SV=3,0,38.237,17,5,24,1,379,42.2,5.1,11766,,5,,regulation of biological process,membrane,,Pf03285,114299,ENSG00000243444.7,PALM2,9,,,,0,High,1
Q15428,Splicing factor 3A subunit 2 OS=Homo sapiens OX=9606 GN=SF3A2 PE=1 SV=2,0,38.229,19,7,46,7,464,49.2,9.64,15894,,7,,cell organization and biogenesis;metabolic process;regulation of biological process,nucleus;spliceosomal complex,metal ion binding;protein binding;RNA binding,Pf12874,8175,ENSG00000104897.9,SF3A2,19,Spliceosome,mRNA Processing,mRNA Splicing - Major Pathway,6,High,1
Q14938-4,Isoform 4 of Nuclear factor 1 X-type OS=Homo sapiens OX=9606 GN=NFIX,0,38.196,18,6,29,4,494,54.1,8.75,11036,22.82,5,2,metabolic process;regulation of biological process,nucleus,DNA binding;protein binding,"Pf00859, Pf03165, Pf10524",4784,ENSG00000008441.16,NFIX,19,,Oxidative Stress,,1,High,1
P06241,Tyrosine-protein kinase Fyn OS=Homo sapiens OX=9606 GN=FYN PE=1 SV=3,0,38.184,16,9,54,3,537,60.7,6.67,27820,,9,,cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;coagulation;defense response;development;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane;mitochondrion;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,"Pf00017, Pf00018, Pf00069, Pf07653, Pf07714, Pf14604",2534,ENSG00000010810.17,FYN,6,T cell receptor signaling pathway; Axon guidance; Adherens junction; Pathogenic Escherichia coli infection; Platelet activation; Fc epsilon RI signaling pathway; Natural killer cell mediated cytotoxicity; Osteoclast differentiation; Sphingolipid signaling pathway; Focal adhesion; Cholinergic synapse; Phospholipase D signaling pathway; Viral myocarditis; Prion diseases; Measles,Integrin-mediated Cell Adhesion; Leptin signaling pathway; Prolactin Signaling Pathway; IL-7 Signaling Pathway; Pathogenic Escherichia coli infection; B Cell Receptor Signaling Pathway; Interleukin-11 Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Primary Focal Segmental Glomerulosclerosis FSGS; T-Cell Receptor and Co-stimulatory Signaling; Ectoderm Differentiation; IL-3 Signaling Pathway; Kit receptor signaling pathway; Focal Adhesion; T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 Signaling Pathway; IL-2 Signaling Pathway; Interferon type I signaling pathways; T-Cell antigen Receptor (TCR)  Signaling Pathway,"SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Sema3A PAK dependent Axon repulsion; PECAM1 interactions; CRMPs in Sema3A signaling; CTLA4 inhibitory signaling; Interleukin-7 signaling; NCAM signaling for neurite out-growth; Nef and signal transduction; EPH-ephrin mediated repulsion of cells; Nephrin family interactions; Ephrin signaling; EPHA-mediated growth cone collapse; DAP12 signaling; EPHB-mediated forward signaling; Reelin signalling pathway; Regulation of signaling by CBL; FCGR activation; Constitutive Signaling by Aberrant PI3K in Cancer; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Interleukin-20 family signaling; DCC mediated attractive signaling; Netrin mediated repulsion signals; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Dectin-2 family; VEGFA-VEGFR2 Pathway; Platelet Adhesion to exposed collagen; CD209 (DC-SIGN) signaling; CD28 dependent Vav1 pathway; GPVI-mediated activation cascade; CD28 dependent PI3K/Akt signaling; Regulation of KIT signaling; Role of LAT2/NTAL/LAB on calcium mobilization; Signaling by ERBB2; RAF/MAP kinase cascade",106,High,1
Q9NXR1-1,Isoform 2 of Nuclear distribution protein nudE homolog 1 OS=Homo sapiens OX=9606 GN=NDE1,0,38.178,32,8,25,8,346,38.8,5.27,12147,0,7,1,cell differentiation;cell division;cell organization and biogenesis;cell proliferation;cellular component movement;development;metabolic process;regulation of biological process;transport,chromosome;cytoplasm;cytoskeleton;cytosol;membrane,protein binding;transporter activity,"Pf01496, Pf04111, Pf04156, Pf04880, Pf05557, Pf05622, Pf09726, Pf12128, Pf13851, Pf13949",54820,,NDE1,16,,,Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins,28,High,1
P46934,E3 ubiquitin-protein ligase NEDD4 OS=Homo sapiens OX=9606 GN=NEDD4 PE=1 SV=4,0,38.165,7,8,36,8,1319,149,6.58,13107,,8,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,chromosome;cytoplasm;cytosol;Golgi;membrane,catalytic activity;protein binding,"Pf00397, Pf00632",4734,ENSG00000069869.15,NEDD4,15,Endocytosis; Epstein-Barr virus infection; Ubiquitin mediated proteolysis,Proteasome Degradation; EGF/EGFR Signaling Pathway,Regulation of PTEN stability and activity; ISG15 antiviral mechanism; Antigen processing: Ubiquitination & Proteasome degradation; Regulation of PTEN localization; Downregulation of ERBB4 signaling,22,High,1
P48553,Trafficking protein particle complex subunit 10 OS=Homo sapiens OX=9606 GN=TRAPPC10 PE=1 SV=2,0,38.158,8,7,36,7,1259,142.1,6.04,15298,,7,,cell organization and biogenesis;transport,cytosol;Golgi;membrane,protein binding;transporter activity,"Pf11817, Pf12584",7109,ENSG00000160218.12,TRAPPC10,21,,,RAB GEFs exchange GTP for GDP on RABs; COPII (Coat Protein 2) Mediated Vesicle Transport,10,High,1
Q02045,Myosin light chain 5 OS=Homo sapiens OX=9606 GN=MYL5 PE=2 SV=1,0,38.096,15,5,1366,1,173,19.5,4.96,672393,0,5,1,regulation of biological process,cytosol,metal ion binding;structural molecule activity,"Pf00036, Pf13405, Pf13833",4636,ENSG00000215375.6,MYL5,4,Focal adhesion; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Tight junction,,Smooth Muscle Contraction,6,High,1
O75937,DnaJ homolog subfamily C member 8 OS=Homo sapiens OX=9606 GN=DNAJC8 PE=1 SV=2,0,38.077,39,7,36,7,253,29.8,9.06,11809,,7,,metabolic process,cytosol;nucleus,protein binding,Pf00226,22826,ENSG00000126698.10,DNAJC8,1,,mRNA Processing,mRNA Splicing - Major Pathway,5,High,1
Q5W0V3,Protein FAM160B1 OS=Homo sapiens OX=9606 GN=FAM160B1 PE=1 SV=1,0,38.076,13,6,26,6,765,86.5,5.29,9217,5.75,6,1,,,,Pf10257,57700,ENSG00000151553.14,FAM160B1,10,,,,0,High,1
P55899,IgG receptor FcRn large subunit p51 OS=Homo sapiens OX=9606 GN=FCGRT PE=1 SV=1,0,38.075,21,5,28,5,365,39.7,6.54,17375,,5,,regulation of biological process;response to stimulus;transport,membrane,protein binding;receptor activity;signal transducer activity,"Pf00129, Pf07654",2217,ENSG00000104870.12,FCGRT,19,,,,0,High,1
Q9Y6N1,"Cytochrome c oxidase assembly protein COX11, mitochondrial OS=Homo sapiens OX=9606 GN=COX11 PE=1 SV=3",0,38.057,14,5,37,5,276,31.4,9.06,14516,,5,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,membrane;mitochondrion,catalytic activity;metal ion binding;protein binding;transporter activity,Pf04442,1353,ENSG00000166260.10,COX11,17,Oxidative phosphorylation; Metabolic pathways,Electron Transport Chain; Copper homeostasis,TP53 Regulates Metabolic Genes; Respiratory electron transport,13,High,1
Q15493,Regucalcin OS=Homo sapiens OX=9606 GN=RGN PE=1 SV=1,0,38.025,28,6,13,6,299,33.2,6.25,6102,,6,,cellular homeostasis;metabolic process;regulation of biological process,cytoplasm;cytosol;extracellular;nucleus,catalytic activity;enzyme regulator activity;metal ion binding,Pf08450,9104,ENSG00000130988.12,RGN,X,Ascorbate and aldarate metabolism; Pentose phosphate pathway; Carbon metabolism; Metabolic pathways,,,4,High,1
Q7L9L4,MOB kinase activator 1B OS=Homo sapiens OX=9606 GN=MOB1B PE=1 SV=3,0,38.019,29,6,66,1,216,25.1,6.73,28367,,6,,regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,enzyme regulator activity;metal ion binding;protein binding,Pf03637,92597,ENSG00000173542.8,MOB1B,4,Hippo signaling pathway -multiple species; Hippo signaling pathway,,Signaling by Hippo,4,High,1
Q9UHW9,Solute carrier family 12 member 6 OS=Homo sapiens OX=9606 GN=SLC12A6 PE=1 SV=2,0,38,7,8,48,2,1150,127.5,7.08,20868,,8,,cell communication;response to stimulus;transport,membrane,protein binding;transporter activity,"Pf00324, Pf01490, Pf03522, Pf13424, Pf13520",9990,ENSG00000140199.11,SLC12A6,15,,,"Cation-coupled Chloride cotransporters; Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)",8,High,1
P15848,Arylsulfatase B OS=Homo sapiens OX=9606 GN=ARSB PE=1 SV=1,0,37.994,16,7,57,7,533,59.6,8.21,22913,,7,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;endoplasmic reticulum;extracellular;Golgi;mitochondrion;organelle lumen;vacuole,catalytic activity;metal ion binding,"Pf00884, Pf14707",411,ENSG00000113273.15,ARSB,5,Glycosaminoglycan degradation; Lysosome; Metabolic pathways,,MPS VI - Maroteaux-Lamy syndrome; Neutrophil degranulation; CS/DS degradation; The activation of arylsulfatases; Glycosphingolipid metabolism,23,High,1
Q96D15,Reticulocalbin-3 OS=Homo sapiens OX=9606 GN=RCN3 PE=1 SV=1,0,37.988,31,6,23,6,328,37.5,4.89,11173,,6,,,endoplasmic reticulum;organelle lumen,metal ion binding;protein binding,Pf13499,57333,ENSG00000142552.7,RCN3,19,,,,0,High,1
Q9H2U1,ATP-dependent DNA/RNA helicase DHX36 OS=Homo sapiens OX=9606 GN=DHX36 PE=1 SV=2,0,37.946,12,10,46,10,1008,114.7,7.68,16722,0,10,1,metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;cytosol;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding,"Pf00270, Pf00271, Pf02562, Pf04408, Pf07717",170506,ENSG00000174953.13,DHX36,3,RNA degradation,,TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling; DEx/H-box helicases activate type I IFN and inflammatory cytokines production ; TRAF6 mediated IRF7 activation,12,High,1
P24666,Low molecular weight phosphotyrosine protein phosphatase OS=Homo sapiens OX=9606 GN=ACP1 PE=1 SV=3,0,37.925,32,4,114,2,158,18,6.74,59552,,4,,metabolic process,cytoplasm;cytosol;membrane,catalytic activity;protein binding,Pf01451,52,ENSG00000143727.15,ACP1,2,Thiamine metabolism; Metabolic pathways; Adherens junction,VEGFA-VEGFR2 Signaling Pathway,,4,High,1
O15021,Microtubule-associated serine/threonine-protein kinase 4 OS=Homo sapiens OX=9606 GN=MAST4 PE=1 SV=4,0,37.916,5,10,18,7,2623,283.9,8.62,5569,4.41,8,3,,,,,,,,,,,,0,High,1
Q9Y383,Putative RNA-binding protein Luc7-like 2 OS=Homo sapiens OX=9606 GN=LUC7L2 PE=1 SV=2,0,37.889,16,6,42,4,392,46.5,10.01,21043,0,6,1,cell organization and biogenesis,nucleus;spliceosomal complex,protein binding;RNA binding,Pf03194,51631,ENSG00000146963.17,LUC7L2,7,,,,0,High,1
O00193,Small acidic protein OS=Homo sapiens OX=9606 GN=SMAP PE=1 SV=1,0,37.883,33,4,28,4,183,20.3,4.72,13685,,4,,,,,Pf15477,10944,ENSG00000110696.9,C11orf58,11,,,,0,High,1
Q96TC7,Regulator of microtubule dynamics protein 3 OS=Homo sapiens OX=9606 GN=RMDN3 PE=1 SV=2,0,37.84,20,8,29,8,470,52.1,5.1,11225,,8,,cell death;cell differentiation;cellular homeostasis,cytoplasm;cytoskeleton;membrane;mitochondrion;nucleus,protein binding,,55177,ENSG00000137824.15,FAM82A2; RMDN3,15,,,,0,High,1
Q99805,Transmembrane 9 superfamily member 2 OS=Homo sapiens OX=9606 GN=TM9SF2 PE=1 SV=1,0,37.775,12,7,30,7,663,75.7,7.44,13497,,7,,transport,endosome;membrane,,"Pf02990, Pf07690",9375,ENSG00000125304.8,TM9SF2,13,,,,0,High,1
O95249,Golgi SNAP receptor complex member 1 OS=Homo sapiens OX=9606 GN=GOSR1 PE=1 SV=1,0,37.774,29,6,38,6,250,28.6,9.42,17269,,6,,cell organization and biogenesis;regulation of biological process;transport,cytosol;Golgi;membrane,protein binding,Pf12352,9527,ENSG00000108587.15,GOSR1,17,SNARE interactions in vesicular transport,,COPI-mediated anterograde transport; Intra-Golgi traffic,11,High,1
P53611,Geranylgeranyl transferase type-2 subunit beta OS=Homo sapiens OX=9606 GN=RABGGTB PE=1 SV=2,0,37.73,16,6,55,6,331,36.9,5.03,26438,,6,,metabolic process;regulation of biological process,cytosol;membrane,catalytic activity;metal ion binding;protein binding,"Pf00432, Pf13243, Pf13249",5876,ENSG00000137955.15,RABGGTB,1,,,TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; RAB geranylgeranylation,9,High,1
O43819,"Protein SCO2 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=SCO2 PE=1 SV=3",0,37.718,30,5,59,5,266,29.8,8.85,25463,,5,,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;transport,membrane;mitochondrion;organelle lumen,antioxidant activity;catalytic activity;metal ion binding;protein binding,"Pf00578, Pf02630, Pf13905",9997,ENSG00000130489.14; ENSG00000284194.1,SCO2,22,Central carbon metabolism in cancer,Copper homeostasis,TP53 Regulates Metabolic Genes; Respiratory electron transport,11,High,1
Q4V328,GRIP1-associated protein 1 OS=Homo sapiens OX=9606 GN=GRIPAP1 PE=1 SV=2,0,37.698,15,9,16,9,841,95.9,5.11,6131,,9,,,,,,,,,,,,,0,High,1
O14936,Peripheral plasma membrane protein CASK OS=Homo sapiens OX=9606 GN=CASK PE=1 SV=3,0,37.69,14,10,27,10,926,105.1,6.43,8608,,10,,metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00018, Pf00069, Pf00595, Pf00625, Pf02828, Pf07653, Pf07714, Pf13180, Pf14604",8573,ENSG00000147044.20,CASK,X,Tight junction,Parkin-Ubiquitin Proteasomal System pathway,Nephrin family interactions; Dopamine Neurotransmitter Release Cycle; Neurexins and neuroligins; Syndecan interactions,13,High,1
Q96EP5,DAZ-associated protein 1 OS=Homo sapiens OX=9606 GN=DAZAP1 PE=1 SV=1,0,37.689,18,4,33,4,407,43.4,8.56,14215,0,4,1,cell differentiation;cell proliferation;development;regulation of biological process,cytoplasm;cytosol;nucleus,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",26528,ENSG00000071626.16,DAZAP1,19,mRNA surveillance pathway,,,1,High,1
Q86TS9,"39S ribosomal protein L52, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL52 PE=1 SV=2",0,37.683,41,3,20,3,123,13.7,10.26,7858,,3,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,structural molecule activity,,122704,ENSG00000172590.18,MRPL52,14,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
Q9NX47,E3 ubiquitin-protein ligase MARCH5 OS=Homo sapiens OX=9606 GN=MARCH5 PE=1 SV=1,0,37.664,26,6,58,6,278,31.2,8.7,23273,0,6,1,metabolic process;regulation of biological process,endoplasmic reticulum;membrane;mitochondrion,catalytic activity;metal ion binding;protein binding,Pf12906,54708,ENSG00000198060.9,MARCH5,10,,,,0,High,1
Q9Y4D1,Disheveled-associated activator of morphogenesis 1 OS=Homo sapiens OX=9606 GN=DAAM1 PE=1 SV=2,0,37.657,8,8,23,6,1078,123.4,7.23,10075,,8,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane,protein binding,"Pf02181, Pf06367, Pf06371",23002,ENSG00000100592.15,DAAM1,14,Wnt signaling pathway,Association Between Physico-Chemical Features and Toxicity Associated Pathways,RHO GTPases Activate Formins; PCP/CE pathway,9,High,1
Q8WVV9,Heterogeneous nuclear ribonucleoprotein L-like OS=Homo sapiens OX=9606 GN=HNRNPLL PE=1 SV=1,0,37.657,17,6,24,6,542,60,7.72,10232,,6,,metabolic process;regulation of biological process,membrane;nucleus,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",92906,ENSG00000143889.15,HNRNPLL; HNRPLL,2,,,,0,High,1
P29353,SHC-transforming protein 1 OS=Homo sapiens OX=9606 GN=SHC1 PE=1 SV=4,0,37.657,19,6,25,6,583,62.8,6.44,11916,,6,,cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;mitochondrion;organelle lumen,protein binding,"Pf00017, Pf00640",6464,ENSG00000160691.18,SHC1,1,Chronic myeloid leukemia; Endocrine resistance; Focal adhesion; Breast cancer; MicroRNAs in cancer; Alcoholism; Glioma; Insulin signaling pathway; Chemokine signaling pathway; Natural killer cell mediated cytotoxicity; Ras signaling pathway; Neurotrophin signaling pathway; Bacterial invasion of epithelial cells; Phospholipase D signaling pathway; EGFR tyrosine kinase inhibitor resistance; Prolactin signaling pathway; Estrogen signaling pathway; ErbB signaling pathway,IL-5 Signaling Pathway; Integrin-mediated Cell Adhesion; Leptin signaling pathway; Prolactin Signaling Pathway; B Cell Receptor Signaling Pathway; AGE/RAGE pathway; Oncostatin M Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Alpha 6 Beta 4 signaling pathway; IL-3 Signaling Pathway; Kit receptor signaling pathway; Focal Adhesion; IL-6 signaling pathway; TGF-beta Signaling Pathway; Hypothesized Pathways in Pathogenesis of Cardiovascular Disease; BDNF-TrkB Signaling; Association Between Physico-Chemical Features and Toxicity Associated Pathways; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; Chemokine signaling pathway; IL-4 Signaling Pathway; p38 MAPK Signaling Pathway; EGF/EGFR Signaling Pathway; Insulin Signaling; IL-2 Signaling Pathway; EPO Receptor Signaling; T-Cell antigen Receptor (TCR)  Signaling Pathway; DNA Damage Response (only ATM dependent),Tie2 Signaling; SHC1 events in ERBB2 signaling; SHC-related events triggered by IGF1R; SHC1 events in ERBB4 signaling; XBP1(S) activates chaperone genes; G beta:gamma signalling through PI3Kgamma; Signal attenuation; Interleukin-20 family signaling; Interleukin-15 signaling; SHC1 events in EGFR signaling; Constitutive Signaling by EGFRvIII; Integrin alphaIIb beta3 signaling; Interleukin receptor SHC signaling; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; GPVI-mediated activation cascade; Signalling to RAS; RET signaling; RAF/MAP kinase cascade,101,High,1
P08729,"Keratin, type II cytoskeletal 7 OS=Homo sapiens OX=9606 GN=KRT7 PE=1 SV=5",0,37.642,9,7,335,1,469,51.4,5.48,175907,,7,,cell death,cytoplasm;cytosol;nucleus,protein binding;structural molecule activity,"Pf00038, Pf12128",3855,ENSG00000135480.15,KRT7,12,,,Formation of the cornified envelope,3,High,1
Q7L523,Ras-related GTP-binding protein A OS=Homo sapiens OX=9606 GN=RRAGA PE=1 SV=1,0,37.628,17,6,62,6,313,36.5,7.72,27683,,6,,cell communication;cell death;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus;vacuole,catalytic activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf01926, Pf04670, Pf08477",10670,ENSG00000155876.5,RRAGA,9,mTOR signaling pathway,Target Of Rapamycin (TOR) Signaling,Energy dependent regulation of mTOR by LKB1-AMPK; E3 ubiquitin ligases ubiquitinate target proteins; Regulation of PTEN gene transcription; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Macroautophagy,21,High,1
P82979,SAP domain-containing ribonucleoprotein OS=Homo sapiens OX=9606 GN=SARNP PE=1 SV=3,0,37.621,34,6,42,6,210,23.7,6.42,17448,,6,,metabolic process;regulation of biological process;transport,nucleus,DNA binding;protein binding;RNA binding,Pf02037,84324,ENSG00000205323.8,SARNP,12,,,Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing,9,High,1
P23946,Chymase OS=Homo sapiens OX=9606 GN=CMA1 PE=1 SV=1,0,37.598,26,5,57,5,247,27.3,9.29,22383,7.18,4,2,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,extracellular,catalytic activity,"Pf00089, Pf13365",1215,ENSG00000092009.10,CMA1,14,Renin-angiotensin system,Lung fibrosis; ACE Inhibitor Pathway,Activation of Matrix Metalloproteinases; Signaling by SCF-KIT; Metabolism of Angiotensinogen to Angiotensins,12,High,1
P08236,Beta-glucuronidase OS=Homo sapiens OX=9606 GN=GUSB PE=1 SV=2,0,37.59,18,9,58,9,651,74.7,7.02,21712,0,9,1,metabolic process;transport,extracellular;membrane;organelle lumen;vacuole,catalytic activity;protein binding,"Pf02836, Pf02837, Pf12876",2990,ENSG00000169919.16,GUSB,7,Pentose and glucuronate interconversions; Drug metabolism - other enzymes; Glycosaminoglycan degradation; Metabolic pathways; Porphyrin and chlorophyll metabolism; Lysosome,,MPS VII - Sly syndrome; Neutrophil degranulation; HS-GAG degradation; Hyaluronan uptake and degradation,21,High,1
Q96QR8,Transcriptional activator protein Pur-beta OS=Homo sapiens OX=9606 GN=PURB PE=1 SV=3,0,37.572,26,5,36,4,312,33.2,5.43,17550,,5,,cell differentiation;cell proliferation;metabolic process;regulation of biological process,nucleus,DNA binding;protein binding;RNA binding,Pf04845,5814,ENSG00000146676.8,PURB,7,,,,0,High,1
P03950,Angiogenin OS=Homo sapiens OX=9606 GN=ANG PE=1 SV=1,0,37.559,18,4,87,4,147,16.5,9.64,27909,,4,,cell communication;cell differentiation;cell organization and biogenesis;cellular component movement;defense response;development;metabolic process;regulation of biological process;response to stimulus,extracellular;nucleus,catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding,Pf00074,283,ENSG00000214274.9,ANG,14,,,Adherens junctions interactions,4,High,1
O94776,Metastasis-associated protein MTA2 OS=Homo sapiens OX=9606 GN=MTA2 PE=1 SV=1,0,37.559,16,8,30,6,668,75,9.66,12058,,8,,cell organization and biogenesis;metabolic process;regulation of biological process,membrane;nucleus,catalytic activity;DNA binding;metal ion binding;protein binding,"Pf00249, Pf00320, Pf01426, Pf01448",9219,ENSG00000149480.6,MTA2,11,,,ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation,20,High,1
P60520,Gamma-aminobutyric acid receptor-associated protein-like 2 OS=Homo sapiens OX=9606 GN=GABARAPL2 PE=1 SV=1,0,37.555,45,7,62,7,117,13.7,8.1,29105,,7,,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;Golgi;membrane;vacuole,protein binding,"Pf02991, Pf04110",11345,ENSG00000034713.7,GABARAPL2,16,Autophagy; NOD-like receptor signaling pathway; GABAergic synapse; FoxO signaling pathway,Senescence and Autophagy in Cancer,TBC/RABGAPs; Macroautophagy,11,High,1
Q53GS9,U4/U6.U5 tri-snRNP-associated protein 2 OS=Homo sapiens OX=9606 GN=USP39 PE=1 SV=2,0,37.552,18,7,26,7,565,65.3,8.91,11056,,7,,cell division;cell organization and biogenesis;metabolic process,nucleus;spliceosomal complex,catalytic activity;metal ion binding,"Pf00443, Pf02148",10713,ENSG00000168883.19,USP39,2,Spliceosome,,mRNA Splicing - Major Pathway,5,High,1
Q01118,Sodium channel protein type 7 subunit alpha OS=Homo sapiens OX=9606 GN=SCN7A PE=1 SV=2,0,37.469,6,9,56,8,1682,193.4,7.96,19142,6.12,7,2,regulation of biological process;transport,membrane,transporter activity,"Pf00520, Pf06512, Pf08016",6332,ENSG00000136546.13,SCN7A,2,Adrenergic signaling in cardiomyocytes,,Phase 0 - rapid depolarisation; Interaction between L1 and Ankyrins,8,High,1
Q8IVD9,NudC domain-containing protein 3 OS=Homo sapiens OX=9606 GN=NUDCD3 PE=1 SV=3,0,37.457,24,7,29,7,361,40.8,5.25,11389,,7,,cell organization and biogenesis;metabolic process,cytoplasm,protein binding,"Pf04969, Pf14050",23386,ENSG00000015676.17,NUDCD3,7,,,,0,High,1
Q9Y2Y0,ADP-ribosylation factor-like protein 2-binding protein OS=Homo sapiens OX=9606 GN=ARL2BP PE=1 SV=1,0,37.431,41,6,31,6,163,18.8,4.35,14264,,6,,regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;mitochondrion;nucleus;organelle lumen,enzyme regulator activity;protein binding,Pf11527,23568,ENSG00000102931.7,ARL2BP,16,,,Regulation of insulin secretion,3,High,1
P82912,"28S ribosomal protein S11, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS11 PE=1 SV=2",0,37.415,37,5,60,5,194,20.6,10.81,27885,10.62,4,1,cell organization and biogenesis;metabolic process;response to stimulus,membrane;mitochondrion;ribosome,RNA binding;structural molecule activity,Pf00411,64963,ENSG00000181991.15,MRPS11,15,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
P12004,Proliferating cell nuclear antigen OS=Homo sapiens OX=9606 GN=PCNA PE=1 SV=1,0,37.368,25,6,48,6,261,28.8,4.69,18733,0,6,1,cell differentiation;cell organization and biogenesis;cell proliferation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,nucleus,catalytic activity;DNA binding;enzyme regulator activity;protein binding,"Pf00705, Pf02747",5111,ENSG00000132646.10,PCNA,20,HTLV-I infection; Hepatitis B; Mismatch repair; Nucleotide excision repair; Base excision repair; DNA replication; Cell cycle,Cell Cycle; Retinoblastoma (RB) in Cancer; Primary Focal Segmental Glomerulosclerosis FSGS; Oxidative Damage; EGF/EGFR Signaling Pathway; G1 to S cell cycle control; DNA Replication; Mismatch repair; Senescence and Autophagy in Cancer,Translesion Synthesis by POLH; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; HDR through Homologous Recombination (HRR); Termination of translesion DNA synthesis; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Polymerase switching on the C-strand of the telomere; Activation of E2F1 target genes at G1/S; Removal of the Flap Intermediate; PCNA-Dependent Long Patch Base Excision Repair; Transcription of E2F targets under negative control by DREAM complex; Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Translesion synthesis by POLK; Gap-filling DNA repair synthesis and ligation in TC-NER; SUMOylation of DNA replication proteins; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Polymerase switching; E3 ubiquitin ligases ubiquitinate target proteins; Dual incision in TC-NER; Removal of the Flap Intermediate from the C-strand,80,High,1
P05089,Arginase-1 OS=Homo sapiens OX=9606 GN=ARG1 PE=1 SV=2,0,37.362,22,5,24,5,322,34.7,7.21,10615,,5,,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen,catalytic activity;metal ion binding,Pf00491,383,ENSG00000118520.14,ARG1,6,Arginine biosynthesis; Metabolic pathways; Amoebiasis; Arginine and proline metabolism; Biosynthesis of amino acids,Spinal Cord Injury; Amino Acid metabolism; Urea cycle and metabolism of amino groups,Urea cycle; Neutrophil degranulation,15,High,1
Q6UX53,Methyltransferase-like protein 7B OS=Homo sapiens OX=9606 GN=METTL7B PE=1 SV=2,0,37.319,20,6,28,6,244,27.8,8.38,10428,,6,,metabolic process,,catalytic activity,"Pf01209, Pf01739, Pf05148, Pf08241, Pf08242, Pf12847, Pf13489, Pf13578, Pf13649, Pf13659, Pf13847",196410,ENSG00000170439.6,METTL7B,12,,,,0,High,1
Q5JTH9,RRP12-like protein OS=Homo sapiens OX=9606 GN=RRP12 PE=1 SV=2,0,37.298,7,8,39,8,1297,143.6,8.75,16359,,8,,,membrane;nucleus,RNA binding,Pf08161,23223,ENSG00000052749.13,RRP12,10,,,,0,High,1
Q9H2K8,Serine/threonine-protein kinase TAO3 OS=Homo sapiens OX=9606 GN=TAOK3 PE=1 SV=2,0,37.271,12,9,32,6,898,105.3,7.3,11992,,9,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;membrane,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf01636, Pf04111, Pf07714, Pf09731, Pf14531",51347,ENSG00000135090.13,TAOK3,12,MAPK signaling pathway,,,1,High,1
O60331,Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma OS=Homo sapiens OX=9606 GN=PIP5K1C PE=1 SV=2,0,37.253,13,6,27,5,668,73.2,5.29,9903,,6,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding,Pf01504,23396,ENSG00000186111.9,PIP5K1C,19,Regulation of actin cytoskeleton; Phospholipase D signaling pathway; Metabolic pathways; Focal adhesion; Phosphatidylinositol signaling system; Endocytosis; Fc gamma R-mediated phagocytosis; Choline metabolism in cancer; Inositol phosphate metabolism,B Cell Receptor Signaling Pathway; Focal Adhesion; Regulation of Actin Cytoskeleton,"SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane",29,High,1
Q15654,Thyroid receptor-interacting protein 6 OS=Homo sapiens OX=9606 GN=TRIP6 PE=1 SV=3,0,37.25,8,3,36,3,476,50.3,7.37,14748,,3,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,metal ion binding;protein binding;RNA binding,Pf00412,7205,ENSG00000087077.13,TRIP6,7,NOD-like receptor signaling pathway,,,1,High,1
P55735,Protein SEC13 homolog OS=Homo sapiens OX=9606 GN=SEC13 PE=1 SV=3,0,37.197,20,4,29,4,322,35.5,5.48,13565,,4,,cell organization and biogenesis;regulation of biological process;transport,chromosome;cytosol;endoplasmic reticulum;membrane;nucleus;vacuole,protein binding,Pf00400,6396,ENSG00000157020.17,SEC13,3,mTOR signaling pathway; RNA transport; Protein processing in endoplasmic reticulum,Sterol Regulatory Element-Binding Proteins (SREBP) signalling,"COPII (Coat Protein 2) Mediated Vesicle Transport; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; RHO GTPases Activate Formins; MHC class II antigen presentation",33,High,1
P82932,"28S ribosomal protein S6, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS6 PE=1 SV=3",0,37.196,35,5,87,5,125,14.2,9.26,37287,,5,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,protein binding;RNA binding;structural molecule activity,Pf01250,64968,ENSG00000243927.5,MRPS6,21,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
Q06190-2,Isoform PR72 of Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha OS=Homo sapiens OX=9606 GN=PPP2R3A,0,37.193,19,8,38,7,529,61.1,5.01,11628,25.48,5,3,metabolic process;regulation of biological process,,enzyme regulator activity;metal ion binding;protein binding,Pf13499,5523,ENSG00000073711.10,PPP2R3A,3,,Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Wnt Signaling Pathway and Pluripotency; Glycogen Metabolism,,3,High,1
Q0VDF9,Heat shock 70 kDa protein 14 OS=Homo sapiens OX=9606 GN=HSPA14 PE=1 SV=1,0,37.188,20,7,21,7,509,54.8,5.59,9288,,7,,cell organization and biogenesis;metabolic process,cytoplasm;cytosol;membrane;ribosome,nucleotide binding;protein binding,"Pf00012, Pf06723",51182,ENSG00000187522.14,HSPA14,10,,Parkin-Ubiquitin Proteasomal System pathway,Regulation of HSF1-mediated heat shock response,5,High,1
Q9Y547,Intraflagellar transport protein 25 homolog OS=Homo sapiens OX=9606 GN=HSPB11 PE=1 SV=1,0,37.155,36,4,18,4,144,16.3,5.03,7807,,4,,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport,,metal ion binding;protein binding,Pf00754,51668,ENSG00000081870.11,HSPB11,1,,,Intraflagellar transport,3,High,1
Q4L180,Filamin A-interacting protein 1-like OS=Homo sapiens OX=9606 GN=FILIP1L PE=1 SV=2,0,37.096,10,9,31,9,1135,130.3,6.57,11859,,9,,metabolic process,cytoplasm;membrane;nucleus,catalytic activity;motor activity,"Pf01576, Pf02463, Pf04111, Pf04156, Pf05109, Pf05911, Pf09727, Pf09731, Pf12072, Pf12128, Pf13166",11259,ENSG00000168386.18,FILIP1L,3,,,,0,High,1
Q8WYA6,Beta-catenin-like protein 1 OS=Homo sapiens OX=9606 GN=CTNNBL1 PE=1 SV=1,0,37.078,15,7,48,7,563,65.1,5.05,20883,0,7,1,cell death;metabolic process;regulation of biological process,cytoplasm;membrane;nucleus;spliceosomal complex,protein binding,Pf08216,56259,ENSG00000132792.18,CTNNBL1,20,Spliceosome,,mRNA Splicing - Major Pathway,5,High,1
Q8WTS1,1-acylglycerol-3-phosphate O-acyltransferase ABHD5 OS=Homo sapiens OX=9606 GN=ABHD5 PE=1 SV=1,0,37.055,29,6,78,5,349,39.1,6.61,41802,,6,,cell differentiation;metabolic process;regulation of biological process,cytoplasm;cytosol,catalytic activity,"Pf00561, Pf12695, Pf12697",51099,ENSG00000011198.7,ABHD5,3,Regulation of lipolysis in adipocytes,,Triglyceride catabolism,5,High,1
Q659C4,La-related protein 1B OS=Homo sapiens OX=9606 GN=LARP1B PE=1 SV=2,0,37.037,7,6,35,2,914,105.3,7.61,15735,,6,,,nucleus,protein binding;RNA binding,Pf05383,55132,ENSG00000138709.17,LARP1B,4,,,,0,High,1
A5YM72,Carnosine synthase 1 OS=Homo sapiens OX=9606 GN=CARNS1 PE=1 SV=3,0,37.032,13,7,25,7,827,88.4,6.21,7522,14.31,7,1,metabolic process,cytosol,catalytic activity;metal ion binding;nucleotide binding,"Pf02655, Pf13535, Pf15632",57571,ENSG00000172508.10,CARNS1,11,beta-Alanine metabolism; Arginine and proline metabolism; Histidine metabolism,,Histidine catabolism,7,High,1
Q13243,Serine/arginine-rich splicing factor 5 OS=Homo sapiens OX=9606 GN=SRSF5 PE=1 SV=1,0,37.012,22,5,42,4,272,31.2,11.59,18893,,5,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;nucleus,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",6430,ENSG00000100650.15,SRSF5,14,Spliceosome; Herpes simplex infection,mRNA Processing,Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway,14,High,1
Q8WU90,Zinc finger CCCH domain-containing protein 15 OS=Homo sapiens OX=9606 GN=ZC3H15 PE=1 SV=1,0,37.012,15,6,32,6,426,48.6,5.31,15579,,6,,regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,metal ion binding;protein binding;RNA binding,Pf00642,55854,ENSG00000065548.17,ZC3H15,2,,,,0,High,1
Q8N4C8,Misshapen-like kinase 1 OS=Homo sapiens OX=9606 GN=MINK1 PE=1 SV=2,0,36.97,7,7,31,1,1332,149.7,7.85,14411,,7,,cell communication;cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;Golgi;membrane,catalytic activity;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf00780, Pf07714, Pf14531",50488,ENSG00000141503.15,MINK1,17,,MAPK Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; Insulin Signaling,Oxidative Stress Induced Senescence,7,High,1
Q15773,Myeloid leukemia factor 2 OS=Homo sapiens OX=9606 GN=MLF2 PE=1 SV=1,0,36.961,36,5,46,5,248,28.1,6.9,18376,0,5,1,defense response;response to stimulus,cytoplasm;membrane;nucleus,protein binding,Pf10248,8079,ENSG00000089693.10,MLF2,12,,,,0,High,1
P13805,"Troponin T, slow skeletal muscle OS=Homo sapiens OX=9606 GN=TNNT1 PE=1 SV=4",0,36.947,5,5,601,1,278,32.9,6.07,300059,0,5,2,cellular component movement;regulation of biological process,cytosol,protein binding,,7138,ENSG00000105048.16,TNNT1,19,,Striated Muscle Contraction,Striated Muscle Contraction,3,High,1
P18754,Regulator of chromosome condensation OS=Homo sapiens OX=9606 GN=RCC1 PE=1 SV=1,0,36.926,32,8,30,8,421,44.9,7.52,12295,,8,,cell division;cell organization and biogenesis;regulation of biological process,chromosome;cytoplasm;membrane;nucleus,DNA binding;protein binding,"Pf00415, Pf13540",1104,ENSG00000180198.15,RCC1,1,,,Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein,9,High,1
Q8IWV7,E3 ubiquitin-protein ligase UBR1 OS=Homo sapiens OX=9606 GN=UBR1 PE=1 SV=1,0,36.924,6,10,40,10,1749,200.1,6.01,15055,0,10,1,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;proteasome,catalytic activity;metal ion binding;protein binding,"Pf02207, Pf02617",197131,ENSG00000159459.11,UBR1,15,,,Antigen processing: Ubiquitination & Proteasome degradation,4,High,1
Q92581-2,Isoform 2 of Sodium/hydrogen exchanger 6 OS=Homo sapiens OX=9606 GN=SLC9A6,0,36.879,12,6,21,6,701,77.9,6.44,7485,10.37,4,2,cell growth;cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport,endosome;membrane;mitochondrion,transporter activity,Pf00999,10479,ENSG00000198689.10,SLC9A6,X,,,,0,High,1
Q9NQ88,"Fructose-2,6-bisphosphatase TIGAR OS=Homo sapiens OX=9606 GN=TIGAR PE=1 SV=1",0,36.878,24,5,51,5,270,30,7.69,24309,,5,,cell death;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;mitochondrion;nucleus,catalytic activity;protein binding,Pf00300,57103,ENSG00000078237.6,C12orf5; TIGAR,12,Central carbon metabolism in cancer; Fructose and mannose metabolism,,TP53 Regulates Metabolic Genes,7,High,1
P48426,Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha OS=Homo sapiens OX=9606 GN=PIP4K2A PE=1 SV=2,0,36.837,19,6,30,4,406,46.2,6.99,12127,,6,,metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;nucleus;vacuole,catalytic activity;nucleotide binding,Pf01504,5305,ENSG00000150867.13,PIP4K2A,10,Inositol phosphate metabolism; Regulation of actin cytoskeleton; Phosphatidylinositol signaling system,Regulation of Actin Cytoskeleton; G13 Signaling Pathway,"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs at the plasma membrane; Synthesis of PIPs in the nucleus",23,High,1
Q15750,TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 OS=Homo sapiens OX=9606 GN=TAB1 PE=1 SV=1,0,36.817,25,7,25,7,504,54.6,5.52,10362,,7,,metabolic process;regulation of biological process;response to stimulus,cytosol;membrane,catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,Pf00481,10454,ENSG00000100324.13,TAB1,22,Toxoplasmosis; Leishmaniasis; NOD-like receptor signaling pathway; Toll-like receptor signaling pathway; MAPK signaling pathway; Osteoclast differentiation; Herpes simplex infection; NF-kappa B signaling pathway; Epstein-Barr virus infection; TNF signaling pathway,Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; TNF alpha Signaling Pathway; Structural Pathway of Interleukin 1 (IL-1); TGF-beta Signaling Pathway; MAPK Signaling Pathway; TLR4 Signaling and Tolerance; Toll-like receptor signaling pathway,"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Ub-specific processing proteases; NOD1/2 Signaling Pathway; IRAK2 mediated activation of TAK1 complex; TRAF6-mediated induction of TAK1 complex within TLR4 complex; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; TNFR1-induced NFkappaB signaling pathway; FCERI mediated NF-kB activation; Activated TLR4 signalling; Interleukin-1 family signaling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; activated TAK1 mediates p38 MAPK activation; TICAM1,TRAF6-dependent induction of TAK1 complex; CLEC7A (Dectin-1) signaling",65,High,1
Q92917,G-patch domain and KOW motifs-containing protein OS=Homo sapiens OX=9606 GN=GPKOW PE=1 SV=2,0,36.812,22,8,28,8,476,52.2,6.15,10154,,8,,metabolic process,nucleus,protein binding,"Pf00467, Pf01585, Pf12656",27238,ENSG00000068394.10,GPKOW,X,,,mRNA Splicing - Major Pathway,4,High,1
Q8IVF7,Formin-like protein 3 OS=Homo sapiens OX=9606 GN=FMNL3 PE=1 SV=3,0,36.812,10,9,29,8,1028,117.1,6.65,12551,0,8,1,cell organization and biogenesis;cellular component movement;development;regulation of biological process,cytoplasm;cytosol;Golgi;membrane,protein binding,"Pf02181, Pf06367, Pf06371",91010,,FMNL3,12,,,RHO GTPases Activate Formins,4,High,1
P61018,Ras-related protein Rab-4B OS=Homo sapiens OX=9606 GN=RAB4B PE=1 SV=1,0,36.793,33,6,50,5,213,23.6,6.06,22104,,6,,regulation of biological process;response to stimulus;transport,endosome;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00009, Pf00025, Pf00071, Pf04670, Pf08477",53916,ENSG00000171570.10; ENSG00000167578.17,RAB4B,19,,,MET receptor recycling; Neutrophil degranulation; RAB geranylgeranylation,10,High,1
Q5VWQ8,Disabled homolog 2-interacting protein OS=Homo sapiens OX=9606 GN=DAB2IP PE=1 SV=2,0,36.782,11,11,29,10,1189,131.5,8.72,9370,1.78,10,1,cell death;cell organization and biogenesis;cellular component movement;defense response;development;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,enzyme regulator activity;protein binding,"Pf00168, Pf00169, Pf00616, Pf12004",153090,ENSG00000136848.16,DAB2IP,9,TNF signaling pathway; Apoptosis,,Regulation of RAS by GAPs; Signaling by RAS mutants; Interleukin-20 family signaling,15,High,1
P56945,Breast cancer anti-estrogen resistance protein 1 OS=Homo sapiens OX=9606 GN=BCAR1 PE=1 SV=2,0,36.769,10,6,17,5,870,93.3,5.67,8199,,6,,cell division;cell organization and biogenesis;cell proliferation;cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane,protein binding;signal transducer activity,"Pf00018, Pf07653, Pf08824, Pf12026, Pf14604",9564,ENSG00000050820.16,BCAR1,16,Leukocyte transendothelial migration; Bacterial invasion of epithelial cells; Rap1 signaling pathway; Chemokine signaling pathway; Focal adhesion; Regulation of actin cytoskeleton,Integrin-mediated Cell Adhesion; Focal Adhesion; TGF-beta Signaling Pathway; VEGFA-VEGFR2 Signaling Pathway; Chemokine signaling pathway; miR-509-3p alteration of YAP1/ECM axis; EGF/EGFR Signaling Pathway; Regulation of Actin Cytoskeleton,"p130Cas linkage to MAPK signaling for integrins; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; VEGFA-VEGFR2 Pathway; Downstream signal transduction",29,High,1
P15954,"Cytochrome c oxidase subunit 7C, mitochondrial OS=Homo sapiens OX=9606 GN=COX7C PE=1 SV=1",0,36.728,44,5,143,5,63,7.2,10.27,64650,,5,,metabolic process;transport,membrane;mitochondrion,catalytic activity;transporter activity,Pf02935,1350,ENSG00000127184.12,COX7C,5,Cardiac muscle contraction; Parkinson's disease; Non-alcoholic fatty liver disease (NAFLD); Alzheimer's disease; Huntington's disease; Metabolic pathways; Oxidative phosphorylation,Electron Transport Chain,TP53 Regulates Metabolic Genes; Respiratory electron transport,17,High,1
P17252,Protein kinase C alpha type OS=Homo sapiens OX=9606 GN=PRKCA PE=1 SV=4,0,36.728,15,7,17,7,672,76.7,7.05,9030,,7,,cell death;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;membrane;mitochondrion;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf00130, Pf00168, Pf00433, Pf07714",5578,ENSG00000154229.11,PRKCA,17,Circadian entrainment; Fc epsilon RI signaling pathway; HIF-1 signaling pathway; Aldosterone-regulated sodium reabsorption; EGFR tyrosine kinase inhibitor resistance; Pathways in cancer; GnRH signaling pathway; Rap1 signaling pathway; Sphingolipid signaling pathway; Vascular smooth muscle contraction; Focal adhesion; Gap junction; African trypanosomiasis; Endocrine and other factor-regulated calcium reabsorption; Inflammatory mediator regulation of TRP channels; MicroRNAs in cancer; Long-term depression; Dopaminergic synapse; Thyroid hormone synthesis; Long-term potentiation; Axon guidance; Non-small cell lung cancer; Gastric acid secretion; Glutamatergic synapse; Proteoglycans in cancer; Phosphatidylinositol signaling system; PI3K-Akt signaling pathway; Morphine addiction; Vibrio cholerae infection; Amphetamine addiction; Aldosterone synthesis and secretion; Serotonergic synapse; Pancreatic secretion; Thyroid hormone signaling pathway; Influenza A; MAPK signaling pathway; GABAergic synapse; Pathogenic Escherichia coli infection; Choline metabolism in cancer; Adrenergic signaling in cardiomyocytes; Natural killer cell mediated cytotoxicity; Ras signaling pathway; Phospholipase D signaling pathway; Retrograde endocannabinoid signaling; Amoebiasis; Melanogenesis; Insulin secretion; Cholinergic synapse; Oxytocin signaling pathway; Salivary secretion; Hepatitis B; mTOR signaling pathway; AGE-RAGE signaling pathway in diabetic complications; ErbB signaling pathway; Fc gamma R-mediated phagocytosis; VEGF signaling pathway; Leukocyte transendothelial migration; Tight junction; Wnt signaling pathway; Glioma; Calcium signaling pathway,Target Of Rapamycin (TOR) Signaling; miRs in Muscle Cell Differentiation; Follicle Stimulating Hormone (FSH) signaling pathway; Regulation of Microtubule Cytoskeleton; Endothelin Pathways; Signaling Pathways in Glioblastoma; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M Signaling Pathway; Spinal Cord Injury; Alpha 6 Beta 4 signaling pathway; T-Cell Receptor and Co-stimulatory Signaling; Common Pathways Underlying Drug Addiction; Cardiac Hypertrophic Response; Myometrial Relaxation and Contraction Pathways; Transcriptional activation by NRF2; Kit receptor signaling pathway; Melatonin metabolism and effects; G Protein Signaling Pathways; Wnt Signaling Pathway Netpath; VEGFA-VEGFR2 Signaling Pathway; Wnt Signaling Pathway and Pluripotency; Wnt Signaling Pathway; EGF/EGFR Signaling Pathway; Insulin Signaling; Calcium Regulation in the Cardiac Cell; ErbB Signaling Pathway,"G alpha (z) signalling events; ROBO receptors bind AKAP5; SHC1 events in ERBB2 signaling; Acetylcholine regulates insulin secretion; Disinhibition of SNARE formation; Syndecan interactions; EGFR Transactivation by Gastrin; WNT5A-dependent internalization of FZD4; Ca2+ pathway; Trafficking of GluR2-containing AMPA receptors; Depolymerisation of the Nuclear Lamina; RET signaling; VEGFR2 mediated cell proliferation; Regulation of KIT signaling; HuR (ELAVL1) binds and stabilizes mRNA; Calmodulin induced events; Inactivation, recovery and regulation of the phototransduction cascade",150,High,1
O00214,Galectin-8 OS=Homo sapiens OX=9606 GN=LGALS8 PE=1 SV=4,0,36.708,20,8,42,6,317,35.8,8.25,16712,,8,,metabolic process;response to stimulus,cytoplasm;cytosol;membrane,protein binding,Pf00337,3964,ENSG00000116977.18,LGALS8,1,,,,0,High,1
Q96EM0,Trans-3-hydroxy-L-proline dehydratase OS=Homo sapiens OX=9606 GN=L3HYPDH PE=1 SV=2,0,36.652,26,6,39,6,354,38.1,6.68,13657,,6,,metabolic process,,catalytic activity,Pf05544,112849,ENSG00000126790.11,L3HYPDH,14,Arginine and proline metabolism,,,1,High,1
Q96AX9,E3 ubiquitin-protein ligase MIB2 OS=Homo sapiens OX=9606 GN=MIB2 PE=1 SV=3,0,36.646,12,8,13,8,1013,109.9,8.44,4048,5.97,5,3,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endosome,catalytic activity;metal ion binding;protein binding;signal transducer activity,"Pf00023, Pf00569, Pf06701, Pf12796, Pf13606, Pf13637, Pf13857, Pf13920, Pf13923, Pf14634",142678,,MIB2,1,,,Activated NOTCH1 Transmits Signal to the Nucleus; NOTCH2 Activation and Transmission of Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Antigen processing: Ubiquitination & Proteasome degradation,19,High,1
P31151,Protein S100-A7 OS=Homo sapiens OX=9606 GN=S100A7 PE=1 SV=4,0,36.644,26,4,35,4,101,11.5,6.77,16025,4.06,4,1,cell differentiation;defense response;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;extracellular;nucleus;organelle lumen,metal ion binding;protein binding,Pf01023,6278,ENSG00000143556.8,S100A7,1,,,Neutrophil degranulation; Metal sequestration by antimicrobial proteins,5,High,1
Q8ND71,GTPase IMAP family member 8 OS=Homo sapiens OX=9606 GN=GIMAP8 PE=2 SV=2,0,36.624,19,9,23,9,665,74.8,8.34,8868,2.79,8,1,,cytoplasm;cytosol;endoplasmic reticulum;Golgi;mitochondrion,catalytic activity;nucleotide binding;RNA binding,"Pf00735, Pf00910, Pf01926, Pf03193, Pf04548",155038,ENSG00000171115.3,GIMAP8,7,,,,0,High,1
Q6UWP2,Dehydrogenase/reductase SDR family member 11 OS=Homo sapiens OX=9606 GN=DHRS11 PE=1 SV=1,0,36.597,24,5,38,5,260,28.3,6.64,18132,,5,,metabolic process,extracellular,catalytic activity;nucleotide binding,"Pf00106, Pf01370, Pf05368, Pf08659, Pf13460, Pf13561",79154,ENSG00000278535.4; ENSG00000275397.2,DHRS11,17; CHR_HSCHR17_7_CTG4,,,,0,High,1
P17480,Nucleolar transcription factor 1 OS=Homo sapiens OX=9606 GN=UBTF PE=1 SV=1,0,36.592,14,8,28,8,764,89.4,5.81,10647,,8,,metabolic process;regulation of biological process,nucleus,DNA binding;protein binding;RNA binding,"Pf00505, Pf09011, Pf14887",7343,ENSG00000108312.14,UBTF,17,,Ectoderm Differentiation,RNA Polymerase I Chain Elongation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Termination; RNA Polymerase I Promoter Escape; RNA Polymerase I Promoter Opening; RNA Polymerase I Transcription Initiation,12,High,1
A0A0C4DH25,Immunoglobulin kappa variable 3D-20 OS=Homo sapiens OX=9606 GN=IGKV3D-20 PE=3 SV=1,0,36.574,51,4,51,1,116,12.5,4.59,26903,,4,,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity,"Pf00047, Pf07686",28874,ENSG00000211625.2,IGKV3D-20,2,,,FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis,26,High,1
Q4KMQ2,Anoctamin-6 OS=Homo sapiens OX=9606 GN=ANO6 PE=1 SV=2,0,36.548,9,7,32,7,910,106.1,7.77,13663,,7,,cell organization and biogenesis;cellular component movement;cellular homeostasis;coagulation;regulation of biological process;response to stimulus;transport,cell surface;cytosol;membrane,protein binding;transporter activity,Pf04547,196527,ENSG00000177119.15,ANO6,12,,,Neutrophil degranulation; Stimuli-sensing channels,6,High,1
Q8WWI5,Choline transporter-like protein 1 OS=Homo sapiens OX=9606 GN=SLC44A1 PE=1 SV=1,0,36.521,10,5,32,5,657,73.3,8.6,16126,,5,,metabolic process;transport,membrane;mitochondrion,transporter activity,Pf04515,23446,ENSG00000070214.15,SLC44A1,9,Choline metabolism in cancer,,"Synthesis of PC; Choline catabolism; Transport of bile salts and organic acids, metal ions and amine compounds",11,High,1
Q8N5K1,CDGSH iron-sulfur domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CISD2 PE=1 SV=1,0,36.516,27,4,46,4,135,15.3,9.61,20252,,4,,metabolic process;regulation of biological process,endoplasmic reticulum;membrane;mitochondrion,metal ion binding;protein binding;RNA binding,"Pf09360, Pf10660",493856,ENSG00000145354.9,CISD2,4,,,,0,High,1
Q53FA7,Quinone oxidoreductase PIG3 OS=Homo sapiens OX=9606 GN=TP53I3 PE=1 SV=2,0,36.514,24,6,39,6,332,35.5,7.17,14818,,6,,metabolic process;regulation of biological process,cytosol,catalytic activity;nucleotide binding;protein binding,"Pf00107, Pf01455, Pf08240, Pf13602",9540,ENSG00000115129.13,TP53I3,2,p53 signaling pathway,,TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain,7,High,1
P11233,Ras-related protein Ral-A OS=Homo sapiens OX=9606 GN=RALA PE=1 SV=1,0,36.514,22,4,159,2,206,23.6,7.11,84571,1.85,4,1,cell division;cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cell surface;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf08477",5898,ENSG00000006451.7,RALA,7,Phospholipase D signaling pathway; Pathways in cancer; Ras signaling pathway; Rap1 signaling pathway; Pancreatic cancer,RalA downstream regulated genes; EGF/EGFR Signaling Pathway,Translocation of GLUT4 to the plasma membrane; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; p38MAPK events; Interleukin-12 family signaling,22,High,1
Q15643,Thyroid receptor-interacting protein 11 OS=Homo sapiens OX=9606 GN=TRIP11 PE=1 SV=3,0,36.507,7,13,41,13,1979,227.4,5.26,12030,,13,,cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;Golgi;membrane;nucleus,protein binding,"Pf04111, Pf08317",9321,ENSG00000100815.12,TRIP11,14,,,Intra-Golgi traffic; Intraflagellar transport,7,High,1
P32004,Neural cell adhesion molecule L1 OS=Homo sapiens OX=9606 GN=L1CAM PE=1 SV=2,0,36.487,10,8,22,8,1257,139.9,6.24,7474,0,8,1,cell differentiation;cell organization and biogenesis;cellular component movement;development;regulation of biological process;response to stimulus,cell surface;membrane,protein binding,"Pf00041, Pf00047, Pf07679, Pf07686, Pf13882, Pf13895, Pf13927",3897,ENSG00000198910.12,L1CAM,X,Axon guidance; Cell adhesion molecules (CAMs),,Basigin interactions; Signal transduction by L1; Recycling pathway of L1; Interaction between L1 and Ankyrins,11,High,1
P61619,Protein transport protein Sec61 subunit alpha isoform 1 OS=Homo sapiens OX=9606 GN=SEC61A1 PE=1 SV=2,0,36.441,13,7,65,3,476,52.2,8.06,23684,0,7,1,cell growth;cell organization and biogenesis;response to stimulus;transport,cytosol;endoplasmic reticulum;membrane,protein binding,"Pf00344, Pf10559",29927,ENSG00000058262.9,SEC61A1,3,Protein processing in endoplasmic reticulum; Vibrio cholerae infection; Protein export; Phagosome,,ER-Phagosome pathway; XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane,15,High,1
Q9HC78,Zinc finger and BTB domain-containing protein 20 OS=Homo sapiens OX=9606 GN=ZBTB20 PE=1 SV=3,0,36.405,13,6,25,6,741,81,6.49,8417,0,6,1,metabolic process;regulation of biological process,nucleus,DNA binding;metal ion binding;protein binding,"Pf00096, Pf00651, Pf13465",26137,ENSG00000181722.16,ZBTB20,3,,,,0,High,1
Q9GZT4,Serine racemase OS=Homo sapiens OX=9606 GN=SRR PE=1 SV=1,0,36.401,26,5,29,5,340,36.5,6.54,12165,,5,,cell organization and biogenesis;metabolic process;response to stimulus,cytoplasm;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding,Pf00291,63826,ENSG00000167720.12,SRR,17,"Metabolic pathways; Glycine, serine and threonine metabolism",,,2,High,1
P55327-6,Isoform 6 of Tumor protein D52 OS=Homo sapiens OX=9606 GN=TPD52,0,36.366,27,6,46,5,247,26.9,5.11,19393,0,6,1,cell differentiation;transport,cytoplasm;endoplasmic reticulum,metal ion binding;protein binding,Pf04201,7163,ENSG00000076554.15,TPD52,8,,,,0,High,1
Q53T59,HCLS1-binding protein 3 OS=Homo sapiens OX=9606 GN=HS1BP3 PE=1 SV=1,0,36.317,29,8,38,8,392,42.8,5.01,13838,,8,,regulation of biological process,endoplasmic reticulum;mitochondrion,,Pf00787,64342,ENSG00000118960.12,HS1BP3,2,,,,0,High,1
Q6VEQ5,WAS protein family homolog 2 OS=Homo sapiens OX=9606 GN=WASH2P PE=2 SV=2,0,36.315,22,7,29,7,465,50.3,5.71,11263,,7,,cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;endosome;membrane;vacuole,protein binding,Pf11945,,,,,,,,0,High,1
Q9BVC4,Target of rapamycin complex subunit LST8 OS=Homo sapiens OX=9606 GN=MLST8 PE=1 SV=1,0,36.31,17,3,13,3,326,35.9,5.86,5795,,3,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytosol,enzyme regulator activity;protein binding,Pf00400,64223,ENSG00000167965.17,MLST8,16,mTOR signaling pathway; PI3K-Akt signaling pathway,Regulation of toll-like receptor signaling pathway; Target Of Rapamycin (TOR) Signaling; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Interferon type I signaling pathways; Senescence and Autophagy in Cancer,HSF1-dependent transactivation; Regulation of TP53 Degradation; mTORC1-mediated signalling; Constitutive Signaling by AKT1 E17K in Cancer; Energy dependent regulation of mTOR by LKB1-AMPK; CD28 dependent PI3K/Akt signaling; Regulation of PTEN gene transcription; VEGFR2 mediated vascular permeability; TP53 Regulates Metabolic Genes; Macroautophagy,43,High,1
Q8TC07,TBC1 domain family member 15 OS=Homo sapiens OX=9606 GN=TBC1D15 PE=1 SV=2,0,36.253,17,9,40,9,691,79.4,5.67,15673,,9,,regulation of biological process;transport,cytoplasm;extracellular;mitochondrion,enzyme regulator activity;protein binding,"Pf00566, Pf12068",64786,ENSG00000121749.15,TBC1D15,12,,,TBC/RABGAPs,4,High,1
Q9Y5P6,Mannose-1-phosphate guanyltransferase beta OS=Homo sapiens OX=9606 GN=GMPPB PE=1 SV=2,0,36.218,22,7,54,7,360,39.8,6.61,22432,,7,,metabolic process,cytoplasm;mitochondrion,catalytic activity;nucleotide binding;protein binding,"Pf00132, Pf00483, Pf12804",29925,ENSG00000173540.12,GMPPB,3,Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways,,Synthesis of GDP-mannose,9,High,1
O43290,U4/U6.U5 tri-snRNP-associated protein 1 OS=Homo sapiens OX=9606 GN=SART1 PE=1 SV=1,0,36.168,12,7,19,7,800,90.2,6.13,8825,,7,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;Golgi;nucleus;spliceosomal complex,protein binding;RNA binding,Pf03343,9092,ENSG00000175467.14,SART1,11,Spliceosome,,mRNA Splicing - Major Pathway,5,High,1
Q13547,Histone deacetylase 1 OS=Homo sapiens OX=9606 GN=HDAC1 PE=1 SV=1,0,36.153,17,6,34,2,482,55.1,5.48,13153,0,6,1,cell differentiation;cell organization and biogenesis;coagulation;metabolic process;regulation of biological process,chromosome;cytoplasm;cytosol;nucleus,catalytic activity;DNA binding;metal ion binding;protein binding,Pf00850,3065,ENSG00000116478.11,HDAC1,1,Pathways in cancer; Chronic myeloid leukemia; Longevity regulating pathway - multiple species; Cell cycle; Transcriptional misregulation in cancer; Huntington's disease; Amphetamine addiction; Viral carcinogenesis; Notch signaling pathway; Alcoholism; Thyroid hormone signaling pathway; Epstein-Barr virus infection; MicroRNAs in cancer,Androgen receptor signaling pathway; Energy Metabolism; Cell Cycle; Integrated Breast Cancer Pathway; TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway; Neural Crest Differentiation; Retinoblastoma (RB) in Cancer; Notch Signaling Pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Initiation of transcription and translation elongation at the HIV-1 LTR; Mecp2 and Associated Rett Syndrome; IL-6 signaling pathway; TGF-beta Signaling Pathway; Valproic acid pathway; VEGFA-VEGFR2 Signaling Pathway; Notch Signaling Pathway; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,NOTCH1 Intracellular Domain Regulates Transcription; NoRC negatively regulates rRNA expression; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Factors involved in megakaryocyte development and platelet production; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Activation of E2F1 target genes at G1/S; HDACs deacetylate histones; Formation of the beta-catenin:TCF transactivating complex; Transcription of E2F targets under negative control by DREAM complex; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Regulation of TP53 Activity through Acetylation; Repression of WNT target genes; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; SUMOylation of chromatin organization proteins; Deactivation of the beta-catenin transactivating complex; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of PTEN gene transcription; Constitutive Signaling by NOTCH1 PEST Domain Mutants; p75NTR negatively regulates cell cycle via SC1; Signalling by NGF; RNA Polymerase I Transcription Initiation,95,High,1
Q15349-2,Isoform 2 of Ribosomal protein S6 kinase alpha-2 OS=Homo sapiens OX=9606 GN=RPS6KA2,0,36.151,9,6,44,1,758,85.5,6.77,16817,4.37,5,1,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf00433, Pf07714, Pf10707, Pf14531",6196,,RPS6KA2,6,,Prolactin Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; EGF/EGFR Signaling Pathway; Cytoplasmic Ribosomal Proteins; Insulin Signaling,,5,High,1
P51797,Chloride transport protein 6 OS=Homo sapiens OX=9606 GN=CLCN6 PE=1 SV=2,0,36.078,12,8,30,8,869,97.2,6.81,9888,,8,,cellular homeostasis;regulation of biological process;response to stimulus;transport,endosome;membrane,nucleotide binding;transporter activity,"Pf00571, Pf00654",1185,ENSG00000011021.21,CLCN6,1,,,Signaling by BRAF and RAF fusions; Stimuli-sensing channels,7,High,1
Q6P3W7,SCY1-like protein 2 OS=Homo sapiens OX=9606 GN=SCYL2 PE=1 SV=1,0,36.073,10,7,41,7,929,103.6,8.22,16970,,7,,metabolic process;regulation of biological process;transport,cytoplasm;endosome;Golgi;membrane,catalytic activity;nucleotide binding;protein binding,Pf00069,55681,ENSG00000136021.18,SCYL2,12,,,,0,High,1
Q9UPV9,Trafficking kinesin-binding protein 1 OS=Homo sapiens OX=9606 GN=TRAK1 PE=1 SV=1,0,36.057,12,7,15,7,953,106,5.85,,37.88,,7,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;endosome;Golgi;mitochondrion;nucleus,catalytic activity;motor activity;protein binding,"Pf01576, Pf02463, Pf03962, Pf04111, Pf04156, Pf04849, Pf05483, Pf05557, Pf06160, Pf07200, Pf07926, Pf09728, Pf09787, Pf10174, Pf10473, Pf12128, Pf12325, Pf12448, Pf13166, Pf13514, Pf13851, Pf13863, Pf14662, Pf14992, Pf15070, Pf15272",22906,ENSG00000182606.14,TRAK1,3,,,Signaling by BRAF and RAF fusions,4,High,1
Q9ULE6,Paladin OS=Homo sapiens OX=9606 GN=PALD1 PE=1 SV=3,0,36.049,11,6,21,6,856,96.7,6.54,8912,,6,,metabolic process,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,Pf14566,27143,ENSG00000107719.8,PALD1,10,,,,0,High,1
P10398,Serine/threonine-protein kinase A-Raf OS=Homo sapiens OX=9606 GN=ARAF PE=1 SV=2,0,36.032,19,8,35,5,606,67.5,9.01,11700,,8,,cell differentiation;development;metabolic process;regulation of biological process;response to stimulus,cytosol;mitochondrion,catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf00130, Pf02196, Pf07714, Pf14531",369,ENSG00000078061.12,ARAF,X,Non-small cell lung cancer; Bladder cancer; FoxO signaling pathway; Prostate cancer; Proteoglycans in cancer; Vascular smooth muscle contraction; Natural killer cell mediated cytotoxicity; Renal cell carcinoma; Endometrial cancer; Alcoholism; Acute myeloid leukemia; Regulation of actin cytoskeleton; Pancreatic cancer; Pathways in cancer; EGFR tyrosine kinase inhibitor resistance; Serotonergic synapse; Colorectal cancer; Glioma; Endocrine resistance; Progesterone-mediated oocyte maturation; Chronic myeloid leukemia; Insulin signaling pathway; Hepatitis C; Long-term potentiation; Long-term depression; ErbB signaling pathway; Melanoma; Breast cancer,Integrin-mediated Cell Adhesion; Signaling Pathways in Glioblastoma; Common Pathways Underlying Drug Addiction; Focal Adhesion; ESC Pluripotency Pathways; MAPK Cascade; ErbB Signaling Pathway,Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling by BRAF and RAF fusions; MAP2K and MAPK activation; Negative regulation of MAPK pathway; RAF activation; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; Interleukin-20 family signaling,54,High,1
Q49A26,Putative oxidoreductase GLYR1 OS=Homo sapiens OX=9606 GN=GLYR1 PE=1 SV=4,0,36.024,19,8,37,8,553,60.5,9.17,15579,1.75,8,1,metabolic process,chromosome;cytosol;Golgi,catalytic activity;DNA binding;nucleotide binding;protein binding,"Pf00855, Pf02737, Pf03446, Pf03807, Pf14833",84656,ENSG00000140632.16,GLYR1,16,,,,0,High,1
P27448,MAP/microtubule affinity-regulating kinase 3 OS=Homo sapiens OX=9606 GN=MARK3 PE=1 SV=5,0,36.014,12,9,52,4,753,84.4,9.57,22429,,9,,,,,,,,,,,,,0,High,1
Q9UII2,"ATPase inhibitor, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5IF1 PE=1 SV=1",0,35.99,41,7,123,7,106,12.2,9.35,62950,0,7,1,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process,cell surface;mitochondrion,catalytic activity;enzyme regulator activity;protein binding,Pf04568,93974,ENSG00000130770.17,ATPIF1,1,,Electron Transport Chain,,1,High,1
P60033,CD81 antigen OS=Homo sapiens OX=9606 GN=CD81 PE=1 SV=1,0,35.927,19,3,33,3,236,25.8,5.29,16994,5.92,2,1,cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport,membrane,protein binding;receptor activity,Pf00335,975,ENSG00000110651.11,CD81,11,Hepatitis C; Malaria; B cell receptor signaling pathway,B Cell Receptor Signaling Pathway,Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell,10,High,1
O00592,Podocalyxin OS=Homo sapiens OX=9606 GN=PODXL PE=1 SV=2,0,35.913,12,5,61,5,558,58.6,5.49,26193,4.2,4,1,cellular component movement;regulation of biological process,cytoplasm;membrane,protein binding,"Pf05109, Pf06365",5420,ENSG00000128567.16,PODXL,7,,Primary Focal Segmental Glomerulosclerosis FSGS; Ectoderm Differentiation; Hepatitis C and Hepatocellular Carcinoma,,3,High,1
Q9BXI3,Cytosolic 5'-nucleotidase 1A OS=Homo sapiens OX=9606 GN=NT5C1A PE=1 SV=1,0,35.821,26,5,22,5,368,41,6.55,8615,10.59,4,1,metabolic process,cytoplasm;cytosol,catalytic activity;metal ion binding;nucleotide binding;protein binding,Pf06189,84618,ENSG00000116981.3,NT5C1A,1,Metabolic pathways; Purine metabolism; Pyrimidine metabolism; Nicotinate and nicotinamide metabolism,,Pyrimidine catabolism; Purine catabolism,9,High,1
P55011,Solute carrier family 12 member 2 OS=Homo sapiens OX=9606 GN=SLC12A2 PE=1 SV=1,0,35.817,10,8,72,8,1212,131.4,6.4,19045,,8,,cellular homeostasis;regulation of biological process;response to stimulus;transport,membrane,catalytic activity;nucleotide binding;protein binding;transporter activity,"Pf00324, Pf08403, Pf13520",6558,ENSG00000064651.13,SLC12A2,5,Pancreatic secretion; Vibrio cholerae infection; Salivary secretion,,Cation-coupled Chloride cotransporters,7,High,1
P13747,"HLA class I histocompatibility antigen, alpha chain E OS=Homo sapiens OX=9606 GN=HLA-E PE=1 SV=4",0,35.817,21,6,51,3,358,40,5.83,22796,,6,,,,,,,,,,,,,0,High,1
Q16540,"39S ribosomal protein L23, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL23 PE=1 SV=1",0,35.796,43,6,33,6,153,17.8,9.69,15377,,6,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,protein binding;RNA binding;structural molecule activity,Pf00276,6150,ENSG00000214026.10,MRPL23,11,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
Q4J6C6,Prolyl endopeptidase-like OS=Homo sapiens OX=9606 GN=PREPL PE=1 SV=1,0,35.75,17,8,35,8,727,83.9,6.38,13351,0,8,1,metabolic process;regulation of biological process,cytoplasm;cytoskeleton;cytosol;Golgi,catalytic activity,"Pf00326, Pf02897",9581,ENSG00000138078.15,PREPL,2,,,,0,High,1
Q9NRF8,CTP synthase 2 OS=Homo sapiens OX=9606 GN=CTPS2 PE=1 SV=1,0,35.661,13,6,31,6,586,65.6,6.9,12999,,6,,metabolic process,cytosol,catalytic activity;nucleotide binding;protein binding,"Pf00117, Pf06418, Pf07722",56474,ENSG00000047230.14,CTPS2,X,Metabolic pathways; Pyrimidine metabolism,,Interconversion of nucleotide di- and triphosphates,5,High,1
Q8NBL1,Protein O-glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=POGLUT1 PE=1 SV=1,0,35.652,18,7,28,7,392,46.2,8.72,11114,,7,,development;metabolic process;regulation of biological process,endoplasmic reticulum;organelle lumen,catalytic activity,Pf05686,56983,ENSG00000163389.10,POGLUT1,3,Other types of O-glycan biosynthesis,,Pre-NOTCH Processing in the Endoplasmic Reticulum,5,High,1
Q0VAK6,Leiomodin-3 OS=Homo sapiens OX=9606 GN=LMOD3 PE=1 SV=1,0,35.6,19,9,33,9,560,64.9,5.54,709,63.81,1,8,cell organization and biogenesis;regulation of biological process,cytoplasm;cytoskeleton,protein binding,Pf03250,56203,ENSG00000163380.15,LMOD3,3,,,,0,High,1
Q8N9N7,Leucine-rich repeat-containing protein 57 OS=Homo sapiens OX=9606 GN=LRRC57 PE=1 SV=1,0,35.599,26,6,30,6,239,26.7,8.43,12228,,6,,,membrane,protein binding,"Pf12799, Pf13855",255252,ENSG00000180979.9,LRRC57,15,,,,0,High,1
Q9NX08,COMM domain-containing protein 8 OS=Homo sapiens OX=9606 GN=COMMD8 PE=1 SV=1,0,35.582,46,5,24,5,183,21.1,5.43,8063,,5,,metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,protein binding,Pf07258,54951,ENSG00000169019.10,COMMD8,4,,,Neddylation,3,High,1
Q16610,Extracellular matrix protein 1 OS=Homo sapiens OX=9606 GN=ECM1 PE=1 SV=2,0,35.582,9,4,22,4,540,60.6,6.71,12587,,4,,defense response;regulation of biological process;response to stimulus;transport,extracellular;organelle lumen,protein binding;signal transducer activity,"Pf05782, Pf09770",1893,ENSG00000143369.14,ECM1,1,,,Platelet degranulation,4,High,1
P31949,Protein S100-A11 OS=Homo sapiens OX=9606 GN=S100A11 PE=1 SV=2,0,35.565,39,5,136,5,105,11.7,7.12,59993,0,5,1,regulation of biological process;response to stimulus;transport,cytoplasm;extracellular;nucleus;organelle lumen,metal ion binding;protein binding,"Pf00036, Pf01023, Pf13499, Pf13833",6282,ENSG00000163191.5,S100A11,1,,,Neutrophil degranulation,3,High,1
Q53FT3,Protein Hikeshi OS=Homo sapiens OX=9606 GN=HIKESHI PE=1 SV=2,0,35.563,23,4,54,4,197,21.6,5.45,24407,,4,,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus,protein binding;transporter activity,Pf05603,51501,ENSG00000149196.15,C11orf73; HIKESHI,11,,,Regulation of HSF1-mediated heat shock response,4,High,1
O43639,Cytoplasmic protein NCK2 OS=Homo sapiens OX=9606 GN=NCK2 PE=1 SV=2,0,35.558,24,6,14,5,380,42.9,6.95,6726,,6,,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;membrane,protein binding;structural molecule activity,"Pf00017, Pf00018, Pf07653, Pf08239, Pf14604",8440,ENSG00000071051.13,NCK2,2,ErbB signaling pathway; Pathogenic Escherichia coli infection; Axon guidance; T cell receptor signaling pathway,Pathogenic Escherichia coli infection; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; EGF/EGFR Signaling Pathway,Nephrin family interactions; Ephrin signaling; Activation of RAC1; VEGFA-VEGFR2 Pathway; Regulation of cortical dendrite branching; Downstream signal transduction,22,High,1
Q5VIR6-4,Isoform 4 of Vacuolar protein sorting-associated protein 53 homolog OS=Homo sapiens OX=9606 GN=VPS53,0,35.511,12,6,22,6,832,94.3,6.7,8176,14.11,5,1,transport,cytosol;endosome;Golgi;membrane,protein binding,"Pf04100, Pf13166",55275,ENSG00000141252.19; ENSG00000283883.1,VPS53,17; CHR_HG2285_HG106_HG2252_PATCH,,,,0,High,1
Q16890,Tumor protein D53 OS=Homo sapiens OX=9606 GN=TPD52L1 PE=1 SV=1,0,35.504,38,7,30,6,204,22.4,5.62,12552,2.35,7,1,regulation of biological process,cytoplasm,protein binding,Pf04201,7164,ENSG00000111907.20,TPD52L1,6,,,Golgi Associated Vesicle Biogenesis,5,High,1
Q9NP61,ADP-ribosylation factor GTPase-activating protein 3 OS=Homo sapiens OX=9606 GN=ARFGAP3 PE=1 SV=1,0,35.5,21,7,32,6,516,56.9,7.36,15217,,7,,regulation of biological process;transport,cytoplasm;cytosol;Golgi;membrane,enzyme regulator activity;metal ion binding;protein binding;transporter activity,Pf01412,26286,ENSG00000242247.10,ARFGAP3,22,Endocytosis,,COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport,12,High,1
O95613,Pericentrin OS=Homo sapiens OX=9606 GN=PCNT PE=1 SV=4,0,35.49,3,9,15,9,3336,377.8,5.55,5806,2.78,8,1,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane,catalytic activity;motor activity;protein binding;structural molecule activity,"Pf01576, Pf09726, Pf09731, Pf10495",5116,ENSG00000160299.16,PCNT,21,,,Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes,16,High,1
P24310,"Cytochrome c oxidase subunit 7A1, mitochondrial OS=Homo sapiens OX=9606 GN=COX7A1 PE=1 SV=2",0,35.44,41,4,313,4,79,9.1,10.11,146831,14.33,3,2,metabolic process;transport,membrane;mitochondrion,catalytic activity;transporter activity,Pf02238,1346,ENSG00000161281.10,COX7A1,19,Cardiac muscle contraction; Alzheimer's disease; Non-alcoholic fatty liver disease (NAFLD); Parkinson's disease; Oxidative phosphorylation; Huntington's disease,Electron Transport Chain,,7,High,1
Q9Y2I1,Nischarin OS=Homo sapiens OX=9606 GN=NISCH PE=1 SV=3,0,35.434,7,8,32,8,1504,166.5,5.14,14917,0,8,1,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane,protein binding,"Pf00787, Pf12799, Pf13855, Pf14580",11188,ENSG00000010322.15,NISCH,3,,,,0,High,1
Q9Y3E2,BolA-like protein 1 OS=Homo sapiens OX=9606 GN=BOLA1 PE=1 SV=1,0,35.422,45,4,33,4,137,14.3,7.96,13821,,4,,,mitochondrion,protein binding,Pf01722,51027,ENSG00000178096.8,BOLA1,1,,,,0,High,1
Q8N5J2,Ubiquitin carboxyl-terminal hydrolase MINDY-1 OS=Homo sapiens OX=9606 GN=MINDY1 PE=1 SV=2,0,35.397,17,4,13,4,469,51.7,4.86,7179,,4,,metabolic process,,catalytic activity;protein binding,Pf04424,55793,ENSG00000143409.15,FAM63A; MINDY1,1,,,,0,High,1
Q9H4G0,Band 4.1-like protein 1 OS=Homo sapiens OX=9606 GN=EPB41L1 PE=1 SV=2,0,35.394,8,6,26,5,881,98.4,5.62,9558,,6,,cell organization and biogenesis,cytoplasm;cytoskeleton;cytosol;membrane,protein binding;structural molecule activity,"Pf00373, Pf04382, Pf05902, Pf08736, Pf09379, Pf09380",2036,ENSG00000088367.21,EPB41L1,20,Tight junction,,Trafficking of AMPA receptors; Neurexins and neuroligins,8,High,1
P31146,Coronin-1A OS=Homo sapiens OX=9606 GN=CORO1A PE=1 SV=4,0,35.389,16,6,40,6,461,51,6.68,18946,,6,,cell organization and biogenesis;cellular component movement;defense response;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endosome;membrane;nucleus,protein binding;RNA binding,"Pf00400, Pf08953, Pf08954, Pf13094, Pf13863",11151,ENSG00000102879.15,CORO1A,16,Tuberculosis; Phagosome,,,2,High,1
Q9P016,Thymocyte nuclear protein 1 OS=Homo sapiens OX=9606 GN=THYN1 PE=1 SV=1,0,35.379,27,7,55,7,225,25.7,9.25,27607,,7,,,nucleus,,Pf01878,29087,ENSG00000151500.14,THYN1,11,,,,0,High,1
Q9Y287,Integral membrane protein 2B OS=Homo sapiens OX=9606 GN=ITM2B PE=1 SV=1,0,35.354,29,5,47,5,266,30.3,5.14,24312,,5,,metabolic process;regulation of biological process,endosome;extracellular;Golgi;membrane,nucleotide binding;protein binding,Pf04089,9445,ENSG00000136156.12,ITM2B,13,,,Amyloid fiber formation,2,High,1
P42766,60S ribosomal protein L35 OS=Homo sapiens OX=9606 GN=RPL35 PE=1 SV=2,0,35.304,22,5,289,4,123,14.5,11.05,154753,0,5,1,cell organization and biogenesis;metabolic process;transport,cytosol;membrane;ribosome,RNA binding;structural molecule activity,Pf00831,11224,ENSG00000136942.14,RPL35,9,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
Q13496,Myotubularin OS=Homo sapiens OX=9606 GN=MTM1 PE=1 SV=2,0,35.301,24,10,25,9,603,69.9,8.18,8045,,10,,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;endosome;membrane,catalytic activity;protein binding,"Pf02893, Pf06602",4534,ENSG00000171100.14,MTM1,X,Inositol phosphate metabolism; Phosphatidylinositol signaling system; Metabolic pathways,,Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane,10,High,1
Q7Z3T8,Zinc finger FYVE domain-containing protein 16 OS=Homo sapiens OX=9606 GN=ZFYVE16 PE=1 SV=3,0,35.296,6,7,18,7,1539,168.8,4.82,7922,,7,,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane,metal ion binding;protein binding;transporter activity,"Pf01363, Pf11951, Pf11979",9765,ENSG00000039319.16,ZFYVE16,5,Endocytosis; TGF-beta signaling pathway,TGF-beta Signaling Pathway,Signaling by BMP,6,High,1
P63098,Calcineurin subunit B type 1 OS=Homo sapiens OX=9606 GN=PPP3R1 PE=1 SV=2,0,35.289,58,7,29,7,170,19.3,4.81,11984,0,7,1,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;mitochondrion,catalytic activity;metal ion binding;protein binding,"Pf00036, Pf12763, Pf13405, Pf13499, Pf13833",5534,ENSG00000221823.10,PPP3R1,2,Natural killer cell mediated cytotoxicity; Renin secretion; Osteoclast differentiation; Oocyte meiosis; Tuberculosis; MAPK signaling pathway; Amphetamine addiction; Axon guidance; Th1 and Th2 cell differentiation; Wnt signaling pathway; B cell receptor signaling pathway; Glucagon signaling pathway; cGMP-PKG signaling pathway; Calcium signaling pathway; Long-term potentiation; Glutamatergic synapse; Amyotrophic lateral sclerosis (ALS); Oxytocin signaling pathway; T cell receptor signaling pathway; Alzheimer's disease; VEGF signaling pathway; HTLV-I infection,Energy Metabolism; TFs Regulate miRNAs related to cardiac hypertrophy; Alzheimers Disease; Initiation of transcription and translation elongation at the HIV-1 LTR; MAPK Signaling Pathway,Signaling by GPCR; FCERI mediated Ca+2 mobilization; DARPP-32 events; Ca2+ pathway; CLEC7A (Dectin-1) induces NFAT activation; Activation of BAD and translocation to mitochondria ; Calcineurin activates NFAT,50,High,1
O14497,AT-rich interactive domain-containing protein 1A OS=Homo sapiens OX=9606 GN=ARID1A PE=1 SV=3,0,35.233,5,7,37,7,2285,241.9,6.7,11780,,7,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,nucleus,DNA binding;protein binding,"Pf01388, Pf12031",8289,ENSG00000117713.18,ARID1A,1,,Pathways Affected in Adenoid Cystic Carcinoma,RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines,9,High,1
Q13137,Calcium-binding and coiled-coil domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CALCOCO2 PE=1 SV=1,0,35.221,21,6,19,6,446,52.2,5.02,8676,5.64,5,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;Golgi;membrane;nucleus;vacuole,catalytic activity;motor activity;protein binding;structural molecule activity,"Pf00038, Pf01576, Pf02463, Pf04111, Pf04156, Pf06160, Pf07888, Pf09728, Pf10174, Pf11559, Pf13779, Pf14662, Pf15066, Pf15070",10241,ENSG00000136436.14,CALCOCO2,17,,,,0,High,1
Q9UK99,F-box only protein 3 OS=Homo sapiens OX=9606 GN=FBXO3 PE=1 SV=3,0,35.2,15,6,32,6,471,54.5,5,15347,,6,,metabolic process;regulation of biological process,cytosol;nucleus,catalytic activity;protein binding,"Pf00646, Pf04379, Pf06881, Pf09346, Pf12937",26273,ENSG00000110429.13,FBXO3,11,,,,0,High,1
Q86V48,Leucine zipper protein 1 OS=Homo sapiens OX=9606 GN=LUZP1 PE=1 SV=2,0,35.188,9,8,19,8,1076,120.2,8.5,9026,,8,,metabolic process,membrane;nucleus,,Pf04111,7798,ENSG00000169641.13,LUZP1,1,,,,0,High,1
Q14197,"Peptidyl-tRNA hydrolase ICT1, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL58 PE=1 SV=1",0,35.179,28,5,44,5,206,23.6,10.07,20111,,5,,cell organization and biogenesis;metabolic process;regulation of biological process,membrane;mitochondrion;organelle lumen;ribosome,catalytic activity;RNA binding,Pf00472,3396,ENSG00000167862.9,ICT1; MRPL58,17,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
O95232,Luc7-like protein 3 OS=Homo sapiens OX=9606 GN=LUC7L3 PE=1 SV=2,0,35.157,19,7,21,7,432,51.4,9.79,8663,,7,,cell organization and biogenesis;metabolic process,nucleus;spliceosomal complex,DNA binding;protein binding;RNA binding,Pf03194,51747,ENSG00000108848.15,LUC7L3,17,,,,0,High,1
P28062,Proteasome subunit beta type-8 OS=Homo sapiens OX=9606 GN=PSMB8 PE=1 SV=3,0,35.107,27,4,11,4,276,30.3,7.43,5766,,4,,cell differentiation;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus;proteasome,catalytic activity;protein binding,Pf00227,5696,ENSG00000235715.6; ENSG00000231631.6; ENSG00000236443.6; ENSG00000206298.8; ENSG00000226201.6; ENSG00000230669.6; ENSG00000204264.8,PSMB8,6; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_APD_CTG1,Proteasome,Proteasome Degradation,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Interferon alpha/beta signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,152,High,1
O60333-3,Isoform 3 of Kinesin-like protein KIF1B OS=Homo sapiens OX=9606 GN=KIF1B,0,35.105,10,9,23,5,1153,130.3,8.43,8184,8.49,8,1,cell communication;cell death;cellular component movement;regulation of biological process;response to stimulus;transport,membrane;mitochondrion,catalytic activity;motor activity;nucleotide binding;protein binding,"Pf00225, Pf00498",23095,ENSG00000054523.17,KIF1B,1,,,,0,High,1
Q86TN4,tRNA 2'-phosphotransferase 1 OS=Homo sapiens OX=9606 GN=TRPT1 PE=1 SV=2,0,35.089,37,6,27,6,253,27.7,9.98,12009,,6,,metabolic process;regulation of biological process,,catalytic activity,Pf01885,83707,ENSG00000149743.13,TRPT1,11,,,,0,High,1
O15258,Protein RER1 OS=Homo sapiens OX=9606 GN=RER1 PE=1 SV=1,0,35.07,34,5,48,5,196,22.9,9.54,21827,,5,,cell organization and biogenesis;regulation of biological process;transport,cell surface;Golgi;membrane,protein binding,Pf03248,11079,ENSG00000157916.19,RER1,1,,,,0,High,1
Q96LJ7,Dehydrogenase/reductase SDR family member 1 OS=Homo sapiens OX=9606 GN=DHRS1 PE=1 SV=1,0,35.045,24,5,25,5,313,33.9,7.83,10875,,5,,metabolic process,endoplasmic reticulum;membrane;mitochondrion,catalytic activity;protein binding,"Pf00106, Pf08659, Pf13561",115817,ENSG00000157379.13,DHRS1,14,,,,0,High,1
P08253,72 kDa type IV collagenase OS=Homo sapiens OX=9606 GN=MMP2 PE=1 SV=2,0,35.043,16,6,33,6,660,73.8,5.47,12655,,6,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;extracellular;membrane;mitochondrion;nucleus,catalytic activity;metal ion binding;protein binding,"Pf00040, Pf00045, Pf00413, Pf01471",4313,ENSG00000087245.12,MMP2,16,Pathways in cancer; Estrogen signaling pathway; Bladder cancer; AGE-RAGE signaling pathway in diabetic complications; GnRH signaling pathway; Leukocyte transendothelial migration; Endocrine resistance; Proteoglycans in cancer,Matrix Metalloproteinases; AGE/RAGE pathway; Photodynamic therapy-induced NF-kB survival signaling; Lung fibrosis; VEGFA-VEGFR2 Signaling Pathway,Collagen degradation; EPH-ephrin mediated repulsion of cells; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Activation of Matrix Metalloproteinases; Interleukin-4 and 13 signaling,27,High,1
Q5EBL4,RILP-like protein 1 OS=Homo sapiens OX=9606 GN=RILPL1 PE=1 SV=1,0,35.031,26,9,25,9,403,47.1,5.21,10547,,9,,cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;membrane,protein binding,"Pf09744, Pf11461",353116,ENSG00000188026.12,RILPL1,12,,,,0,High,1
P00748,Coagulation factor XII OS=Homo sapiens OX=9606 GN=F12 PE=1 SV=3,0,35.007,9,5,58,5,615,67.7,7.74,28559,,5,,coagulation;defense response;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity;metal ion binding;protein binding;transporter activity,"Pf00083, Pf03092, Pf13347",2161,ENSG00000131187.9,F12,5,Complement and coagulation cascades,Blood Clotting Cascade; Complement and Coagulation Cascades,Intrinsic Pathway of Fibrin Clot Formation,6,High,1
P20936,Ras GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RASA1 PE=1 SV=1,0,34.96,11,9,32,9,1047,116.3,6.54,12448,,9,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;enzyme regulator activity;protein binding,"Pf00017, Pf00018, Pf00168, Pf00169, Pf00616, Pf14604",5921,ENSG00000145715.14,RASA1,5,Axon guidance; MAPK signaling pathway; Ras signaling pathway,PDGF Pathway; T-Cell Receptor and Co-stimulatory Signaling; Signaling of Hepatocyte Growth Factor Receptor; Rac1/Pak1/p38/MMP-2 pathway; MAPK Signaling Pathway; EGF/EGFR Signaling Pathway; EPO Receptor Signaling,"Regulation of RAS by GAPs; Signaling by RAS mutants; Downstream signal transduction; EPHB-mediated forward signaling; VEGFR2 mediated cell proliferation; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; Interleukin-20 family signaling",36,High,1
P46779,60S ribosomal protein L28 OS=Homo sapiens OX=9606 GN=RPL28 PE=1 SV=3,0,34.958,28,4,70,4,137,15.7,12.02,36375,,4,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytosol;membrane;ribosome,protein binding;RNA binding;structural molecule activity,Pf01778,6158,ENSG00000108107.14,RPL28,19,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
Q16222,UDP-N-acetylhexosamine pyrophosphorylase OS=Homo sapiens OX=9606 GN=UAP1 PE=1 SV=3,0,34.937,16,6,36,5,522,58.7,6.33,18167,,6,,metabolic process,cytoplasm;cytosol;membrane,catalytic activity;protein binding,Pf01704,6675,ENSG00000117143.13,UAP1,1,Metabolic pathways; Amino sugar and nucleotide sugar metabolism,,Synthesis of UDP-N-acetyl-glucosamine,8,High,1
Q5EBL8,PDZ domain-containing protein 11 OS=Homo sapiens OX=9606 GN=PDZD11 PE=1 SV=2,0,34.917,50,5,59,5,140,16.1,7.21,21939,2.06,5,1,cell organization and biogenesis;metabolic process;response to stimulus;transport,cytoplasm;cytosol;extracellular;membrane,protein binding,"Pf00595, Pf13180",51248,ENSG00000120509.10,PDZD11,X,,,"Transport of vitamins, nucleosides, and related molecules; Ion influx/efflux at host-pathogen interface; Vitamin B5 (pantothenate) metabolism; Biotin transport and metabolism; Ion transport by P-type ATPases",14,High,1
Q643R3,Lysophospholipid acyltransferase LPCAT4 OS=Homo sapiens OX=9606 GN=LPCAT4 PE=1 SV=1,0,34.906,21,7,35,7,524,57.2,8.97,13471,,7,,metabolic process,endoplasmic reticulum;membrane,catalytic activity,Pf01553,254531,ENSG00000176454.13,LPCAT4,15,Ether lipid metabolism; Metabolic pathways; Glycerophospholipid metabolism,,Synthesis of PA; Acyl chain remodelling of PG; Acyl chain remodelling of PS; Acyl chain remodelling of PE; Acyl chain remodelling of PC,12,High,1
Q8NI37,Protein phosphatase PTC7 homolog OS=Homo sapiens OX=9606 GN=PPTC7 PE=1 SV=1,0,34.858,22,5,42,5,304,32.6,5.19,13739,0,5,2,metabolic process,mitochondrion,catalytic activity;metal ion binding,"Pf00481, Pf07228",160760,ENSG00000196850.5,PPTC7,12,,,,0,High,1
Q68E01,Integrator complex subunit 3 OS=Homo sapiens OX=9606 GN=INTS3 PE=1 SV=1,0,34.846,10,7,20,7,1043,118,5.8,8952,,7,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,protein binding,Pf10189,65123,,INTS3,1,,,RNA polymerase II transcribes snRNA genes,3,High,1
Q96DZ1,Endoplasmic reticulum lectin 1 OS=Homo sapiens OX=9606 GN=ERLEC1 PE=1 SV=1,0,34.845,17,7,22,7,483,54.8,6.28,9952,,7,,metabolic process;transport,endoplasmic reticulum;organelle lumen,protein binding,"Pf07915, Pf13015",27248,ENSG00000068912.13,ERLEC1,2,Protein processing in endoplasmic reticulum,,Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Hedgehog ligand biogenesis,13,High,1
Q9P2X3,Protein IMPACT OS=Homo sapiens OX=9606 GN=IMPACT PE=1 SV=2,0,34.783,20,6,28,6,320,36.5,4.97,12000,,6,,cell communication;cell differentiation;cell growth;regulation of biological process;response to stimulus,cytoplasm,protein binding,"Pf01205, Pf05773",55364,ENSG00000154059.9,IMPACT,18,,,,0,High,1
Q5SXM8,DNL-type zinc finger protein OS=Homo sapiens OX=9606 GN=DNLZ PE=1 SV=1,0,34.775,34,4,35,4,178,19.2,9.8,12082,8.2,4,1,metabolic process;regulation of biological process;transport,mitochondrion,metal ion binding;protein binding,Pf05180,728489,ENSG00000213221.4,DNLZ,9,,,,0,High,1
P49674,Casein kinase I isoform epsilon OS=Homo sapiens OX=9606 GN=CSNK1E PE=1 SV=1,0,34.747,24,9,34,1,416,47.3,9.66,12760,,9,,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00069, Pf01636, Pf07714",1454; 102800317,ENSG00000213923.11; ENSG00000283900.1,CSNK1E; LOC400927-CSNK1E,22,Hippo signaling pathway; FoxO signaling pathway; Circadian rhythm; Hippo signaling pathway -multiple species; Wnt signaling pathway; Hedgehog signaling pathway,Melatonin metabolism and effects; Wnt Signaling Pathway Netpath; Wnt Signaling Pathway and Pluripotency; Wnt Signaling Pathway,WNT mediated activation of DVL; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Circadian Clock,35,High,1
Q9H3M7,Thioredoxin-interacting protein OS=Homo sapiens OX=9606 GN=TXNIP PE=1 SV=1,0,34.709,19,5,30,5,391,43.6,7.5,15264,,5,,cell differentiation;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus,enzyme regulator activity;protein binding,"Pf00339, Pf02752",10628,ENSG00000265972.5,TXNIP; LOC101060503,1,NOD-like receptor signaling pathway,VEGFA-VEGFR2 Signaling Pathway,The NLRP3 inflammasome,7,High,1
O94819,Kelch repeat and BTB domain-containing protein 11 OS=Homo sapiens OX=9606 GN=KBTBD11 PE=1 SV=1,0,34.66,14,6,27,6,623,65.7,6.07,9374,4.9,6,2,metabolic process,,catalytic activity;protein binding,"Pf00651, Pf01344, Pf13964",9920,ENSG00000176595.3; ENSG00000273645.2,KBTBD11,8; CHR_HSCHR8_8_CTG1,,,,0,High,1
Q99719,Septin-5 OS=Homo sapiens OX=9606 GN=SEPTIN5 PE=1 SV=1,0,34.641,15,4,33,4,369,42.8,6.67,15027,0,4,1,cell division;regulation of biological process,cytoplasm;cytoskeleton;membrane,catalytic activity;nucleotide binding;protein binding;structural molecule activity,"Pf00735, Pf03193",5413,ENSG00000184702.17,SEPT5,22,Parkinson's disease,Parkin-Ubiquitin Proteasomal System pathway; Parkinsons Disease Pathway,,3,High,1
Q99996-1,Isoform 1 of A-kinase anchor protein 9 OS=Homo sapiens OX=9606 GN=AKAP9,0,34.637,3,10,49,10,3911,453.4,4.98,16872,,10,,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;Golgi,DNA binding;protein binding;structural molecule activity,"Pf10186, Pf10495",10142,,AKAP9,7,,G Protein Signaling Pathways,"Signaling by BRAF and RAF fusions; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Phase 3 - rapid repolarisation; Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; Ras activation uopn Ca2+ infux through NMDA receptor; Phase 2 - plateau phase; Unblocking of NMDA receptor, glutamate binding and activation; CREB phosphorylation through the activation of CaMKII; RAF/MAP kinase cascade; Interleukin-20 family signaling",42,High,1
Q14156,Protein EFR3 homolog A OS=Homo sapiens OX=9606 GN=EFR3A PE=1 SV=2,0,34.609,11,6,22,5,821,92.9,6.7,9602,,6,,cell organization and biogenesis;metabolic process,cytoplasm;cytosol;membrane,,,23167,ENSG00000132294.14,EFR3A,8,,,,0,High,1
Q7Z5Q1,Cytoplasmic polyadenylation element-binding protein 2 OS=Homo sapiens OX=9606 GN=CPEB2 PE=2 SV=3,0,34.561,16,6,31,1,589,64.9,7.21,13769,,6,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,enzyme regulator activity;RNA binding;translation regulator activity,"Pf00076, Pf14259",132864,ENSG00000283087.1; ENSG00000137449.15,CPEB2,4; CHR_HSCHR4_2_CTG4,Oocyte meiosis; Dorso-ventral axis formation; Progesterone-mediated oocyte maturation,,,3,High,1
Q9H299,SH3 domain-binding glutamic acid-rich-like protein 3 OS=Homo sapiens OX=9606 GN=SH3BGRL3 PE=1 SV=1,0,34.548,32,4,38,4,93,10.4,4.93,16267,,4,,cellular homeostasis;metabolic process;regulation of biological process,cytoplasm;nucleus,catalytic activity,"Pf00462, Pf04908",83442,ENSG00000142669.14,SH3BGRL3,1,,,,0,High,1
Q92930,Ras-related protein Rab-8B OS=Homo sapiens OX=9606 GN=RAB8B PE=1 SV=2,0,34.501,36,7,129,2,207,23.6,9.07,70966,,7,,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,endosome;membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf04670, Pf08477",51762,ENSG00000166128.12,RAB8B,15,,Ectoderm Differentiation,TBC/RABGAPs; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation,9,High,1
P05362,Intercellular adhesion molecule 1 OS=Homo sapiens OX=9606 GN=ICAM1 PE=1 SV=2,0,34.491,15,6,53,6,532,57.8,7.99,22535,,6,,cell communication;cell organization and biogenesis;cellular component movement;cellular homeostasis;defense response;regulation of biological process;response to stimulus,cell surface;membrane,protein binding;receptor activity;signal transducer activity,"Pf03921, Pf07679, Pf13895",3383,ENSG00000090339.8,ICAM1,19,Cell adhesion molecules (CAMs); Rheumatoid arthritis; Viral myocarditis; NF-kappa B signaling pathway; TNF signaling pathway; Influenza A; Malaria; AGE-RAGE signaling pathway in diabetic complications; African trypanosomiasis; Natural killer cell mediated cytotoxicity; Staphylococcus aureus infection; Epstein-Barr virus infection; Leukocyte transendothelial migration; HTLV-I infection,Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; Interleukin-11 Signaling Pathway; Spinal Cord Injury; IL1 and megakaryocytes in obesity; Photodynamic therapy-induced NF-kB survival signaling; VEGFA-VEGFR2 Signaling Pathway; Type II interferon signaling (IFNG),Integrin cell surface interactions; Interleukin-10 signaling; Interleukin-4 and 13 signaling; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Interferon gamma signaling,35,High,1
O75886,Signal transducing adapter molecule 2 OS=Homo sapiens OX=9606 GN=STAM2 PE=1 SV=1,0,34.487,14,7,22,6,525,58.1,5.07,9986,,7,,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane,protein binding,"Pf00018, Pf00790, Pf07653, Pf14604",10254,ENSG00000115145.9,STAM2,2,Endocytosis; Jak-STAT signaling pathway,EGF/EGFR Signaling Pathway,Cargo recognition for clathrin-mediated endocytosis; Negative regulation of MET activity; Ub-specific processing proteases; EGFR downregulation; InlB-mediated entry of Listeria monocytogenes into host cell; Endosomal Sorting Complex Required For Transport (ESCRT),22,High,1
Q96LL9,"DnaJ homolog subfamily C member 30, mitochondrial OS=Homo sapiens OX=9606 GN=DNAJC30 PE=1 SV=3",0,34.478,31,5,40,5,226,25.9,10.49,16110,,5,,,cytosol;mitochondrion,,Pf00226,84277,ENSG00000176410.7,DNAJC30,7,,,,0,High,1
Q4G0I0,Protein CCSMST1 OS=Homo sapiens OX=9606 GN=CCSMST1 PE=2 SV=1,0,34.468,40,6,24,6,132,15,7.02,10260,,6,,,membrane,,Pf15013,283951,ENSG00000174109.4,C16orf91,16,,,,0,High,1
Q9NUV9,GTPase IMAP family member 4 OS=Homo sapiens OX=9606 GN=GIMAP4 PE=1 SV=1,0,34.433,16,5,51,5,329,37.5,7.81,22365,,5,,,cytoplasm;cytosol,nucleotide binding,"Pf00350, Pf01926, Pf04548",55303,ENSG00000133574.9,GIMAP4,7,,,,0,High,1
P53680,AP-2 complex subunit sigma OS=Homo sapiens OX=9606 GN=AP2S1 PE=1 SV=2,0,34.41,37,5,92,5,142,17,6.18,37744,,5,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;membrane,protein binding;transporter activity,Pf01217,1175,ENSG00000042753.11,AP2S1,19,Endocrine and other factor-regulated calcium reabsorption; Endocytosis; Synaptic vesicle cycle; Huntington's disease,Synaptic Vesicle Pathway; EGF/EGFR Signaling Pathway,"Cargo recognition for clathrin-mediated endocytosis; Nef Mediated CD8 Down-regulation; Nef Mediated CD4 Down-regulation; Trafficking of GluR2-containing AMPA receptors; Recycling pathway of L1; LDL clearance; EPH-ephrin mediated repulsion of cells; Retrograde neurotrophin signalling; VLDLR internalisation and degradation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; MHC class II antigen presentation; WNT5A-dependent internalization of FZD4",48,High,1
P61925,cAMP-dependent protein kinase inhibitor alpha OS=Homo sapiens OX=9606 GN=PKIA PE=1 SV=2,0,34.378,47,2,30,2,76,8,4.54,14812,10.2,2,1,metabolic process;regulation of biological process,cytoplasm;nucleus,catalytic activity;enzyme regulator activity;protein binding,Pf02827,5569,ENSG00000171033.12,PKIA,8,Alcoholism,Myometrial Relaxation and Contraction Pathways; Calcium Regulation in the Cardiac Cell,,3,High,1
Q5U5X0,Complex III assembly factor LYRM7 OS=Homo sapiens OX=9606 GN=LYRM7 PE=1 SV=1,0,34.374,39,3,69,3,104,11.9,9.66,27193,13.61,2,1,cell organization and biogenesis;metabolic process,membrane;mitochondrion;organelle lumen,protein binding,"Pf05347, Pf13232",90624,ENSG00000186687.15,LYRM7,5,,,,0,High,1
P49747,Cartilage oligomeric matrix protein OS=Homo sapiens OX=9606 GN=COMP PE=1 SV=2,0,34.303,6,5,87,1,757,82.8,4.6,37380,,5,,cell death;cell organization and biogenesis;regulation of biological process,extracellular,metal ion binding;protein binding;structural molecule activity,"Pf02412, Pf05735, Pf07645, Pf11598, Pf12947",1311,ENSG00000105664.10,COMP,19,PI3K-Akt signaling pathway; Phagosome; Malaria; ECM-receptor interaction; Focal adhesion,Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,ECM proteoglycans; Integrin cell surface interactions,10,High,1
Q9P266,Junctional protein associated with coronary artery disease OS=Homo sapiens OX=9606 GN=JCAD PE=1 SV=3,0,34.278,9,10,30,10,1359,148.3,7.09,9884,,10,,regulation of biological process,,,Pf15351,57608,ENSG00000165757.8,KIAA1462; JCAD,10,,,,0,High,1
P23458,Tyrosine-protein kinase JAK1 OS=Homo sapiens OX=9606 GN=JAK1 PE=1 SV=2,0,34.262,8,6,24,6,1154,133.2,7.55,11670,,6,,cell differentiation;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;endosome;membrane;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf07714",3716,ENSG00000162434.11,JAK1,1,EGFR tyrosine kinase inhibitor resistance; Pancreatic cancer; Th1 and Th2 cell differentiation; Signaling pathways regulating pluripotency of stem cells; Toxoplasmosis; Pathways in cancer; Osteoclast differentiation; PI3K-Akt signaling pathway; Herpes simplex infection; Epstein-Barr virus infection; Jak-STAT signaling pathway; Hepatitis B; HTLV-I infection; NOD-like receptor signaling pathway; Influenza A; Tuberculosis; Viral carcinogenesis; Hepatitis C; Leishmaniasis; Measles,IL-5 Signaling Pathway; Human Thyroid Stimulating Hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin Signaling Pathway; IL-7 Signaling Pathway; IL17 signaling pathway; Type III interferon signaling; IL-9 Signaling Pathway; Interleukin-11 Signaling Pathway; Oncostatin M Signaling Pathway; IL-3 Signaling Pathway; TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer; IL-6 signaling pathway; Hepatitis C and Hepatocellular Carcinoma; ESC Pluripotency Pathways; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; IL-4 Signaling Pathway; EGF/EGFR Signaling Pathway; IL-2 Signaling Pathway; TGF-beta Receptor Signaling; Interferon type I signaling pathways; Type II interferon signaling (IFNG),Interleukin-15 signaling; ISG15 antiviral mechanism; IL-6-type cytokine receptor ligand interactions; MAPK3 (ERK1) activation; Interleukin-35 Signalling; Interleukin-10 signaling; Interleukin-7 signaling; G beta:gamma signalling through PI3Kgamma; Interleukin receptor SHC signaling; Other interleukin signaling; Regulation of IFNA signaling; GPVI-mediated activation cascade; Regulation of IFNG signaling; Interleukin-4 and 13 signaling; RAF/MAP kinase cascade; MAPK1 (ERK2) activation; Interleukin-9 signaling; Interleukin-20 family signaling,80,High,1
Q9NVP1,ATP-dependent RNA helicase DDX18 OS=Homo sapiens OX=9606 GN=DDX18 PE=1 SV=2,0,34.179,14,6,23,6,670,75.4,9.5,8438,,6,,metabolic process;response to stimulus,chromosome;cytoplasm;membrane;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding,"Pf00270, Pf00271, Pf04851, Pf13959",8886,ENSG00000088205.12,DDX18,2,,,,0,High,1
Q9UGP4,LIM domain-containing protein 1 OS=Homo sapiens OX=9606 GN=LIMD1 PE=1 SV=1,0,34.174,19,7,28,7,676,72.1,6.65,9872,,7,,cell organization and biogenesis;cellular component movement;development;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,metal ion binding;protein binding,Pf00412,8994,ENSG00000144791.9,LIMD1,3,Hippo signaling pathway -multiple species; Hippo signaling pathway,,Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha,7,High,1
P05230,Fibroblast growth factor 1 OS=Homo sapiens OX=9606 GN=FGF1 PE=1 SV=1,0,34.173,36,5,50,5,155,17.4,7.02,24306,,5,,cell communication;cell differentiation;cell proliferation;development;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;extracellular;nucleus,catalytic activity;protein binding,Pf00167,2246,ENSG00000113578.17,FGF1,5,Ras signaling pathway; Breast cancer; Melanoma; Rap1 signaling pathway; PI3K-Akt signaling pathway; Regulation of actin cytoskeleton; Pathways in cancer; MAPK signaling pathway; Hippo signaling pathway,Differentiation Pathway; Lung fibrosis; ESC Pluripotency Pathways; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Regulation of Actin Cytoskeleton,"PI3K Cascade; Signaling by FGFR2 IIIa TM; SHC-mediated cascade:FGFR4; PI-3K cascade:FGFR3; FRS-mediated FGFR4 signaling; Signaling by activated point mutants of FGFR1; Activated point mutants of FGFR2; Negative regulation of FGFR2 signaling; Negative regulation of FGFR1 signaling; FGFR4 ligand binding and activation; PI-3K cascade:FGFR4; SHC-mediated cascade:FGFR2; Constitutive Signaling by Aberrant PI3K in Cancer; Interleukin-20 family signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Phospholipase C-mediated cascade: FGFR1; FGFR2b ligand binding and activation; Negative regulation of FGFR4 signaling; FGFR1c ligand binding and activation; Phospholipase C-mediated cascade; FGFR2; Negative regulation of FGFR3 signaling; FGFR2c ligand binding and activation; FGFR1b ligand binding and activation; FGFR3b ligand binding and activation; FGFR3c ligand binding and activation; FRS-mediated FGFR3 signaling; Signaling by activated point mutants of FGFR3; SHC-mediated cascade:FGFR3; FRS-mediated FGFR2 signaling; Phospholipase C-mediated cascade; FGFR4; FRS-mediated FGFR1 signaling; Phospholipase C-mediated cascade; FGFR3; PI-3K cascade:FGFR2; SHC-mediated cascade:FGFR1; PI-3K cascade:FGFR1; RAF/MAP kinase cascade",89,High,1
Q9NY47,Voltage-dependent calcium channel subunit alpha-2/delta-2 OS=Homo sapiens OX=9606 GN=CACNA2D2 PE=1 SV=2,0,34.167,6,6,26,4,1150,129.7,5.8,11863,,6,,cell organization and biogenesis;regulation of biological process;transport,membrane,metal ion binding;transporter activity,"Pf00092, Pf02743, Pf08269, Pf08399, Pf08473, Pf13519, Pf13768",9254,ENSG00000007402.11,CACNA2D2,3,Oxytocin signaling pathway; Cardiac muscle contraction; Dilated cardiomyopathy; Hypertrophic cardiomyopathy (HCM); Adrenergic signaling in cardiomyocytes; MAPK signaling pathway; Arrhythmogenic right ventricular cardiomyopathy (ARVC),Arrhythmogenic Right Ventricular Cardiomyopathy,"Adrenaline,noradrenaline inhibits insulin secretion; Phase 0 - rapid depolarisation; Phase 2 - plateau phase; Presynaptic depolarization and calcium channel opening",19,High,1
Q8IZ81,ELMO domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ELMOD2 PE=1 SV=1,0,34.139,22,7,35,7,293,34.9,8.05,14084,,7,,defense response;regulation of biological process;response to stimulus,membrane,enzyme regulator activity,Pf04727,255520,ENSG00000179387.9,ELMOD2,4,,Lung fibrosis,,1,High,1
P20592,Interferon-induced GTP-binding protein Mx2 OS=Homo sapiens OX=9606 GN=MX2 PE=1 SV=1,0,34.126,13,7,41,5,715,82,8.76,16959,,7,,cell organization and biogenesis;defense response;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00350, Pf01031, Pf02212",4600,ENSG00000183486.12,MX2,21,,,Interferon alpha/beta signaling; ISG15 antiviral mechanism,6,High,1
Q8WXE0,Caskin-2 OS=Homo sapiens OX=9606 GN=CASKIN2 PE=1 SV=2,0,34.078,10,7,13,7,1202,126.7,7.09,6243,,7,,,cytoplasm;membrane,protein binding,"Pf00018, Pf00023, Pf00536, Pf07647, Pf07653, Pf12796, Pf13606, Pf13637, Pf13857, Pf14604",57513,ENSG00000177303.9,CASKIN2,17,,,,0,High,1
Q9BZZ2,Sialoadhesin OS=Homo sapiens OX=9606 GN=SIGLEC1 PE=1 SV=2,0,34.076,7,7,25,7,1709,182.5,6.62,9508,,7,,defense response;response to stimulus;transport,extracellular;membrane,protein binding,"Pf00047, Pf07679, Pf07686, Pf08205, Pf13895, Pf13927",6614,ENSG00000088827.12,SIGLEC1,20,Cell adhesion molecules (CAMs),,Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell,4,High,1
P15559,NAD(P)H dehydrogenase [quinone] 1 OS=Homo sapiens OX=9606 GN=NQO1 PE=1 SV=1,0,34.073,29,8,30,8,274,30.8,8.88,12456,,8,,cell communication;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,antioxidant activity;catalytic activity;protein binding;RNA binding,"Pf02525, Pf03358",1728,ENSG00000181019.12,NQO1,16,Ubiquinone and other terpenoid-quinone biosynthesis,Dopamine metabolism; Aryl Hydrocarbon Receptor; Apoptosis-related network due to altered Notch3 in ovarian cancer; Aryl Hydrocarbon Receptor Pathway; NRF2 pathway; Transcriptional activation by NRF2; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway; Benzene metabolism; Oxidative Stress; Estrogen metabolism,Regulation of ornithine decarboxylase (ODC),16,High,1
Q8N2G8,GH3 domain-containing protein OS=Homo sapiens OX=9606 GN=GHDC PE=1 SV=2,0,34.052,19,8,32,8,530,57.5,7.88,12687,,8,,transport,endoplasmic reticulum;extracellular;membrane;nucleus;organelle lumen,,Pf03321,84514,ENSG00000167925.15,GHDC,17,,,Neutrophil degranulation,3,High,1
Q6NYC1,Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 OS=Homo sapiens OX=9606 GN=JMJD6 PE=1 SV=1,0,33.928,20,5,29,5,403,46.4,8.69,10694,,5,,cell differentiation;cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;membrane;nucleus,catalytic activity;metal ion binding;protein binding;receptor activity;RNA binding,"Pf02373, Pf13621",23210,ENSG00000070495.14,JMJD6,17,,,HDMs demethylate histones,3,High,1
Q07075,Glutamyl aminopeptidase OS=Homo sapiens OX=9606 GN=ENPEP PE=1 SV=3,0,33.902,11,8,21,8,957,109.2,5.47,7074,4.31,8,1,cell communication;cell proliferation;cellular component movement;metabolic process,membrane,catalytic activity;metal ion binding,"Pf01433, Pf11838, Pf13485",2028,ENSG00000138792.9,ENPEP,4,Renin-angiotensin system,,Metabolism of Angiotensinogen to Angiotensins,4,High,1
A0A0C4DH69,Immunoglobulin kappa variable 1-9 OS=Homo sapiens OX=9606 GN=IGKV1-9 PE=3 SV=1,0,33.876,42,5,48,2,117,12.7,8.29,22061,,5,,response to stimulus,extracellular;membrane,,"Pf00047, Pf07679, Pf07686, Pf13927",28941,ENSG00000282758.1; ENSG00000241755.1,IGKV1-9,CHR_HG2290_PATCH; 2,,,,0,High,1
Q9NX62,"Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase OS=Homo sapiens OX=9606 GN=IMPAD1 PE=1 SV=1",0,33.844,36,5,24,5,359,38.7,6.86,9787,0,5,1,metabolic process,cytosol;Golgi;membrane;nucleus;organelle lumen,catalytic activity;metal ion binding,Pf00459,54928,ENSG00000104331.8,IMPAD1,8,Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Sulfur metabolism,,Cytosolic sulfonation of small molecules,8,High,1
Q9NZM3,Intersectin-2 OS=Homo sapiens OX=9606 GN=ITSN2 PE=1 SV=3,0,33.776,6,8,31,7,1697,193.3,8.12,10867,,8,,cell differentiation;regulation of biological process;transport,cytoplasm,metal ion binding;protein binding,"Pf00018, Pf00168, Pf00621, Pf07653, Pf12763, Pf14604",50618,ENSG00000198399.14,ITSN2,2,,,Cargo recognition for clathrin-mediated endocytosis,4,High,1
Q9BVC6,Transmembrane protein 109 OS=Homo sapiens OX=9606 GN=TMEM109 PE=1 SV=1,0,33.762,9,4,67,4,243,26.2,10.48,34642,,4,,regulation of biological process;response to stimulus;transport,endoplasmic reticulum;membrane;nucleus,transporter activity,Pf14965,79073,ENSG00000110108.9,TMEM109,11,,,,0,High,1
Q9P2F8,Signal-induced proliferation-associated 1-like protein 2 OS=Homo sapiens OX=9606 GN=SIPA1L2 PE=1 SV=2,0,33.756,8,8,17,8,1722,190.3,6.77,6102,,8,,regulation of biological process,,enzyme regulator activity;protein binding,"Pf00595, Pf02145, Pf11881",57568,ENSG00000116991.10,SIPA1L2,1,Rap1 signaling pathway,,,1,High,1
Q96CW5,Gamma-tubulin complex component 3 OS=Homo sapiens OX=9606 GN=TUBGCP3 PE=1 SV=2,0,33.745,12,7,20,7,907,103.5,8.12,7422,0,7,1,cell organization and biogenesis,cytoplasm;cytoskeleton;cytosol;membrane,protein binding;structural molecule activity,Pf04130,10426,ENSG00000126216.13,TUBGCP3,13,,,Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes,9,High,1
Q96H78,Solute carrier family 25 member 44 OS=Homo sapiens OX=9606 GN=SLC25A44 PE=2 SV=1,0,33.74,28,6,16,6,314,35.4,9.63,5417,8.42,5,1,transport,membrane;mitochondrion,transporter activity,Pf00153,9673,ENSG00000160785.13,SLC25A44,1,,,,0,High,1
Q12882,Dihydropyrimidine dehydrogenase [NADP(+)] OS=Homo sapiens OX=9606 GN=DPYD PE=1 SV=2,0,33.71,8,7,25,7,1025,111.3,7.05,9050,,7,,metabolic process,cytoplasm;cytosol,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf01180, Pf01207, Pf07992, Pf12838, Pf13183, Pf13187, Pf13237, Pf13450, Pf14691, Pf14697",1806,ENSG00000188641.12,DPYD,1,Pyrimidine metabolism; Pantothenate and CoA biosynthesis; Drug metabolism - other enzymes; Metabolic pathways; beta-Alanine metabolism,Fluoropyrimidine Activity; TYROBP Causal Network,Pyrimidine catabolism,11,High,1
Q8N4Q1,Mitochondrial intermembrane space import and assembly protein 40 OS=Homo sapiens OX=9606 GN=CHCHD4 PE=1 SV=1,0,33.701,18,3,17,3,142,16,4.31,9954,,3,,metabolic process;transport,mitochondrion,catalytic activity;protein binding,Pf06747,131474,ENSG00000163528.12,CHCHD4,3,,,Mitochondrial protein import; Metabolism of proteins,2,High,1
Q96GC5,"39S ribosomal protein L48, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL48 PE=1 SV=2",0,33.67,22,4,45,4,212,23.9,8.98,20334,,4,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,protein binding,Pf00338,51642,ENSG00000175581.13,MRPL48,11,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
Q969Q5,Ras-related protein Rab-24 OS=Homo sapiens OX=9606 GN=RAB24 PE=1 SV=1,0,33.655,39,7,32,7,203,23.1,6.23,15057,0,7,1,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;mitochondrion;vacuole,catalytic activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf08477",53917,ENSG00000169228.13,RAB24,5,,,Neutrophil degranulation; RAB geranylgeranylation,6,High,1
P51531,Probable global transcription activator SNF2L2 OS=Homo sapiens OX=9606 GN=SMARCA2 PE=1 SV=2,0,33.648,5,7,32,4,1590,181.2,7.2,12301,,7,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoskeleton;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding,"Pf00176, Pf00270, Pf00271, Pf00439, Pf07529, Pf07533, Pf08880, Pf11496, Pf14619",6595,ENSG00000080503.22,SMARCA2,9,,Retinoblastoma (RB) in Cancer; Pathways Affected in Adenoid Cystic Carcinoma; VEGFA-VEGFR2 Signaling Pathway,RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines,11,High,1
Q13685,Angio-associated migratory cell protein OS=Homo sapiens OX=9606 GN=AAMP PE=1 SV=2,0,33.634,17,6,26,6,434,46.7,4.42,9944,0,6,1,cell differentiation;cellular component movement;development;regulation of biological process,cell surface;cytoplasm;cytoskeleton;cytosol;membrane,protein binding,"Pf00400, Pf14134",14,ENSG00000127837.9,AAMP,2,,Nucleotide-binding Oligomerization Domain (NOD) pathway,,1,High,1
Q6P9B6,MTOR-associated protein MEAK7 OS=Homo sapiens OX=9606 GN=MEAK7 PE=1 SV=2,0,33.623,15,4,31,4,456,51,6.24,11694,,4,,regulation of biological process,cytoplasm;membrane,protein binding,Pf07534,57707,ENSG00000140950.15,KIAA1609; TLDC1,16,,,,0,High,1
P48723,Heat shock 70 kDa protein 13 OS=Homo sapiens OX=9606 GN=HSPA13 PE=1 SV=1,0,33.605,16,6,23,6,471,51.9,5.76,9276,,6,,cell organization and biogenesis,endoplasmic reticulum,nucleotide binding;protein binding,"Pf00012, Pf06723",6782,ENSG00000155304.5,HSPA13,21,,,Regulation of HSF1-mediated heat shock response,4,High,1
O60830,Mitochondrial import inner membrane translocase subunit Tim17-B OS=Homo sapiens OX=9606 GN=TIMM17B PE=1 SV=1,0,33.557,29,3,23,3,172,18.3,9.03,11972,0,3,1,transport,membrane;mitochondrion,protein binding;transporter activity,Pf02466,10245,ENSG00000126768.12,TIMM17B,X,,,Mitochondrial protein import; Metabolism of proteins,2,High,1
Q8NHP8,Putative phospholipase B-like 2 OS=Homo sapiens OX=9606 GN=PLBD2 PE=1 SV=2,0,33.531,14,6,36,6,589,65.4,6.8,14941,,6,,metabolic process,organelle lumen;vacuole,catalytic activity,Pf04916,196463,ENSG00000151176.7,PLBD2,12,,,,0,High,1
Q9HCH3,Copine-5 OS=Homo sapiens OX=9606 GN=CPNE5 PE=1 SV=2,0,33.527,15,7,76,3,593,65.7,5.99,41399,,7,,cell differentiation,,protein binding,"Pf00168, Pf07002, Pf10138",57699,ENSG00000124772.11,CPNE5,6,,,,0,High,1
Q9GZR7,ATP-dependent RNA helicase DDX24 OS=Homo sapiens OX=9606 GN=DDX24 PE=1 SV=1,0,33.512,12,8,22,8,859,96.3,9.06,9506,0,8,1,metabolic process,cytoplasm;membrane,catalytic activity;nucleotide binding;RNA binding,"Pf00270, Pf00271, Pf13307",57062,ENSG00000273761.5; ENSG00000089737.16,DDX24,14; CHR_HSCHR14_7_CTG1,,,,0,High,1
Q99456,"Keratin, type I cytoskeletal 12 OS=Homo sapiens OX=9606 GN=KRT12 PE=1 SV=1",0,33.508,6,5,285,1,494,53.5,4.78,156322,,5,,cell death,cytosol,structural molecule activity,Pf00038,3859,ENSG00000263243.2; ENSG00000187242.4,KRT12,17; CHR_HSCHR17_4_CTG4,,,Formation of the cornified envelope,3,High,1
Q05519,Serine/arginine-rich splicing factor 11 OS=Homo sapiens OX=9606 GN=SRSF11 PE=1 SV=1,0,33.488,21,5,62,5,484,53.5,10.52,25446,,5,,metabolic process;transport,nucleus,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",9295,ENSG00000116754.13,SRSF11,1,,,Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway,11,High,1
Q96QD9,UAP56-interacting factor OS=Homo sapiens OX=9606 GN=FYTTD1 PE=1 SV=3,0,33.451,29,8,41,8,318,35.8,11.78,12591,0,8,1,transport,nucleus,protein binding;RNA binding,Pf07078,84248,ENSG00000122068.12,FYTTD1,3,,,Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing,9,High,1
Q9UBV8,Peflin OS=Homo sapiens OX=9606 GN=PEF1 PE=1 SV=1,0,33.446,18,5,56,5,284,30.4,6.54,25052,,5,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;membrane,catalytic activity;metal ion binding;protein binding;RNA binding,"Pf00036, Pf13202, Pf13405, Pf13499, Pf13833",553115,ENSG00000162517.12,PEF1,1,,,,0,High,1
P23193,Transcription elongation factor A protein 1 OS=Homo sapiens OX=9606 GN=TCEA1 PE=1 SV=2,0,33.4,26,7,35,7,301,33.9,8.38,15771,,7,,metabolic process;regulation of biological process;response to stimulus,nucleus,DNA binding;metal ion binding;protein binding,"Pf01096, Pf07500, Pf08711",6917,ENSG00000187735.13,TCEA1,8,,,HIV elongation arrest and recovery; Gap-filling DNA repair synthesis and ligation in TC-NER; TP53 Regulates Transcription of DNA Repair Genes; Dual incision in TC-NER; Tat-mediated HIV elongation arrest and recovery; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; Formation of HIV elongation complex in the absence of HIV Tat; Formation of TC-NER Pre-Incision Complex; Pausing and recovery of HIV elongation; Pausing and recovery of Tat-mediated HIV elongation; Formation of HIV-1 elongation complex containing HIV-1 Tat,28,High,1
O95848,Uridine diphosphate glucose pyrophosphatase NUDT14 OS=Homo sapiens OX=9606 GN=NUDT14 PE=1 SV=2,0,33.397,43,6,21,6,222,24.1,5.05,10120,,6,,metabolic process,cytoplasm;cytosol,catalytic activity;metal ion binding;protein binding,Pf00293,256281,ENSG00000183828.14,NUDT14,14,,,Synthesis of dolichyl-phosphate-glucose,6,High,1
O75935,Dynactin subunit 3 OS=Homo sapiens OX=9606 GN=DCTN3 PE=1 SV=1,0,33.388,32,7,99,7,186,21.1,5.47,49921,,7,,cell division;regulation of biological process;transport,chromosome;cytoplasm;cytoskeleton;cytosol,protein binding;structural molecule activity,Pf07426,11258,ENSG00000137100.15,DCTN3,9,,,COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR),33,High,1
Q16864,V-type proton ATPase subunit F OS=Homo sapiens OX=9606 GN=ATP6V1F PE=1 SV=2,0,33.386,43,5,26,5,119,13.4,5.52,11086,,5,,cellular homeostasis;regulation of biological process;response to stimulus;transport,cytosol;membrane,catalytic activity;protein binding;transporter activity,Pf01990,9296,ENSG00000128524.4,ATP6V1F,7,Metabolic pathways; mTOR signaling pathway; Collecting duct acid secretion; Vibrio cholerae infection; Phagosome; Rheumatoid arthritis; Epithelial cell signaling in Helicobacter pylori infection; Oxidative phosphorylation; Synaptic vesicle cycle,,"Transferrin endocytosis and recycling; ROS, RNS production in phagocytes; Ion channel transport; Insulin receptor recycling",20,High,1
O00401,Neural Wiskott-Aldrich syndrome protein OS=Homo sapiens OX=9606 GN=WASL PE=1 SV=2,0,33.358,19,7,20,7,505,54.8,7.93,8012,,7,,cell division;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,catalytic activity;enzyme regulator activity;protein binding,"Pf00568, Pf00786, Pf02205",8976; 142685,ENSG00000106299.7,WASL; ASB15,7,Shigellosis; Regulation of actin cytoskeleton; Endocytosis; Fc gamma R-mediated phagocytosis; Salmonella infection; Pathogenic Escherichia coli infection; Chemokine signaling pathway; Bacterial invasion of epithelial cells; Adherens junction; Choline metabolism in cancer,Pathogenic Escherichia coli infection; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Chemokine signaling pathway; G13 Signaling Pathway,Nephrin family interactions; DCC mediated attractive signaling; EPHB-mediated forward signaling; Clathrin-mediated endocytosis; RHO GTPases Activate WASPs and WAVEs; NOSTRIN mediated eNOS trafficking; Regulation of actin dynamics for phagocytic cup formation,37,High,1
Q8WWQ0,PH-interacting protein OS=Homo sapiens OX=9606 GN=PHIP PE=1 SV=2,0,33.328,7,7,19,6,1821,206.6,8.85,7217,,7,,cell organization and biogenesis;regulation of biological process;response to stimulus,nucleus,protein binding,"Pf00400, Pf00439",55023,ENSG00000146247.13,PHIP,6,,,,0,High,1
O00625,Pirin OS=Homo sapiens OX=9606 GN=PIR PE=1 SV=1,0,33.317,34,6,28,6,290,32.1,6.92,11541,,6,,cell differentiation;metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;protein binding,"Pf02678, Pf05726",8544,ENSG00000087842.10,PIR,X,,,Digestion,2,High,1
O75381,Peroxisomal membrane protein PEX14 OS=Homo sapiens OX=9606 GN=PEX14 PE=1 SV=1,0,33.313,28,6,35,6,377,41.2,4.94,14669,,6,,cell organization and biogenesis;cellular component movement;regulation of biological process;transport,membrane;nucleus,protein binding,Pf04695,5195,ENSG00000142655.12,PEX14,1,Peroxisome,,,1,High,1
P40306,Proteasome subunit beta type-10 OS=Homo sapiens OX=9606 GN=PSMB10 PE=1 SV=1,0,33.31,21,4,24,4,273,28.9,7.81,11894,,4,,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus;proteasome,catalytic activity;protein binding,"Pf00227, Pf12465",5699,ENSG00000205220.11,PSMB10,16,Proteasome,Proteasome Degradation,Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,150,High,1
Q8IWZ3,Ankyrin repeat and KH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ANKHD1 PE=1 SV=1,0,33.304,4,8,22,4,2542,269.3,5.73,8514,,8,,defense response;response to stimulus,cytoplasm,protein binding;RNA binding,"Pf00013, Pf00023, Pf12796, Pf13014, Pf13606, Pf13637, Pf13857",54882; 404734,ENSG00000131503.20,ANKHD1; ANKHD1-EIF4EBP3,5,,,,0,High,1
O75494,Serine/arginine-rich splicing factor 10 OS=Homo sapiens OX=9606 GN=SRSF10 PE=1 SV=1,0,33.278,19,5,41,5,262,31.3,11.27,19582,,5,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;nucleus,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",10772,ENSG00000188529.14,SRSF10; LOC100996657,1,Spliceosome,mRNA Processing,mRNA Splicing - Major Pathway,6,High,1
O60869,Endothelial differentiation-related factor 1 OS=Homo sapiens OX=9606 GN=EDF1 PE=1 SV=1,0,33.265,25,4,32,4,148,16.4,9.95,12816,0,4,1,cell differentiation;development;metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;DNA binding;protein binding;RNA binding,"Pf01381, Pf08523, Pf12844, Pf13560",8721,ENSG00000107223.12,EDF1,9,,,,0,High,1
Q9Y320,Thioredoxin-related transmembrane protein 2 OS=Homo sapiens OX=9606 GN=TMX2 PE=1 SV=1,0,33.25,28,6,43,6,296,34,8.69,15415,,6,,cellular homeostasis;regulation of biological process,membrane,,Pf00085,51075,ENSG00000213593.9,TMX2,11,,,,0,High,1
P61326,Protein mago nashi homolog OS=Homo sapiens OX=9606 GN=MAGOH PE=1 SV=1,0,33.237,42,6,60,1,146,17.2,6.11,25019,1.89,6,1,metabolic process;regulation of biological process;transport,cytoplasm;nucleus;spliceosomal complex,protein binding;RNA binding,Pf02792,4116,ENSG00000162385.10,MAGOH,1,mRNA surveillance pathway; RNA transport; Spliceosome,,mRNA 3'-end processing; mRNA Splicing - Major Pathway; Cleavage of Growing Transcript in the Termination Region ; Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC),20,High,1
O43402,ER membrane protein complex subunit 8 OS=Homo sapiens OX=9606 GN=EMC8 PE=1 SV=1,0,33.193,25,5,26,5,210,23.8,6.4,10346,,5,,,cytoplasm;cytosol;membrane;mitochondrion;nucleus,protein binding,Pf03665,10328,ENSG00000131148.8,EMC8,16,,,,0,High,1
O15111,Inhibitor of nuclear factor kappa-B kinase subunit alpha OS=Homo sapiens OX=9606 GN=CHUK PE=1 SV=2,0,33.192,12,7,27,7,745,84.6,6.73,10322,,7,,cell differentiation;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf07714, Pf12179",1147,ENSG00000213341.10,CHUK,10,Th1 and Th2 cell differentiation; NF-kappa B signaling pathway; PI3K-Akt signaling pathway; Acute myeloid leukemia; RIG-I-like receptor signaling pathway; FoxO signaling pathway; Small cell lung cancer; NOD-like receptor signaling pathway; Apoptosis; Pathways in cancer; Chemokine signaling pathway; Epstein-Barr virus infection; Hepatitis C; Hepatitis B; mTOR signaling pathway; T cell receptor signaling pathway; HTLV-I infection; Shigellosis; Chronic myeloid leukemia; Toll-like receptor signaling pathway; Chagas disease (American trypanosomiasis); Prostate cancer; Adipocytokine signaling pathway; Pancreatic cancer; Measles; MAPK signaling pathway; Epithelial cell signaling in Helicobacter pylori infection; Osteoclast differentiation; Cytosolic DNA-sensing pathway; B cell receptor signaling pathway; Ras signaling pathway; TNF signaling pathway; Toxoplasmosis; Antifolate resistance; Herpes simplex infection,Nucleotide-binding Oligomerization Domain (NOD) pathway; Osteopontin Signaling; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; Leptin signaling pathway; TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway; B Cell Receptor Signaling Pathway; TNF alpha Signaling Pathway; AGE/RAGE pathway; Interleukin-11 Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Apoptosis; EBV LMP1 signaling; Structural Pathway of Interleukin 1 (IL-1); Cardiac Hypertrophic Response; NLR Proteins; Rac1/Pak1/p38/MMP-2 pathway; Photodynamic therapy-induced NF-kB survival signaling; Canonical  and Non-canonical Notch signaling; MAPK  and NFkB Signalling Pathways Inhibited by Yersinia YopJ; Toll-like Receptor Signaling; T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection; RIG-I-like Receptor Signaling; Chemokine signaling pathway; IL-4 Signaling Pathway; T-Cell antigen Receptor (TCR)  Signaling Pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway,"IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); Downstream TCR signaling; NOD1/2 Signaling Pathway; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; TRAF6 mediated NF-kB activation; TICAM1, RIP1-mediated IKK complex recruitment ; NIK-->noncanonical NF-kB signaling; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; TNFR1-induced NFkappaB signaling pathway; RIP-mediated NFkB activation via ZBP1; Activated TLR4 signalling; Interleukin-1 family signaling; IRAK1 recruits IKK complex; AKT phosphorylates targets in the cytosol; IKBKB deficiency causes SCID; IKK complex recruitment mediated by RIP1; ER-Phagosome pathway; FCERI mediated NF-kB activation; Constitutive Signaling by AKT1 E17K in Cancer; Activation of NF-kappaB in B cells; Regulation of TNFR1 signaling; Dectin-1 mediated noncanonical NF-kB signaling; IkBA variant leads to EDA-ID",136,High,1
Q9NQL2,Ras-related GTP-binding protein D OS=Homo sapiens OX=9606 GN=RRAGD PE=1 SV=1,0,33.167,20,6,46,1,400,45.6,4.92,22304,0,5,2,cell communication;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus;vacuole,catalytic activity;nucleotide binding;protein binding,"Pf00025, Pf04670, Pf08477",58528,ENSG00000025039.14,RRAGD,6,mTOR signaling pathway,Target Of Rapamycin (TOR) Signaling,Energy dependent regulation of mTOR by LKB1-AMPK; Regulation of PTEN gene transcription; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Macroautophagy,17,High,1
O75884,Serine hydrolase RBBP9 OS=Homo sapiens OX=9606 GN=RBBP9 PE=1 SV=2,0,33.153,38,5,35,5,186,21,6.2,15314,,5,,regulation of biological process,cytoplasm;nucleus,catalytic activity;protein binding,,10741,ENSG00000089050.15,RBBP9,20,,,,0,High,1
Q9Y3D0,Cytosolic iron-sulfur assembly component 2B OS=Homo sapiens OX=9606 GN=CIAO2B PE=1 SV=1,0,33.147,55,5,24,5,163,17.7,5.19,10934,,5,,cell organization and biogenesis;metabolic process,cytoplasm;cytoskeleton;cytosol;nucleus,protein binding,Pf01883,51647,ENSG00000166595.11,FAM96B,16,,,Cytosolic iron-sulfur cluster assembly,2,High,1
Q14714,Sarcospan OS=Homo sapiens OX=9606 GN=SSPN PE=2 SV=3,0,33.125,15,4,68,4,243,26.6,7.8,30243,0,3,2,,membrane,,Pf04103,8082,ENSG00000123096.11,SSPN,12,,,,0,High,1
Q99470,Stromal cell-derived factor 2 OS=Homo sapiens OX=9606 GN=SDF2 PE=1 SV=2,0,33.092,29,3,12,3,211,23,7.33,5116,,3,,metabolic process;response to stimulus,extracellular;membrane,catalytic activity,Pf02815,6388,ENSG00000132581.9,SDF2,17,,,,0,High,1
Q15147,"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 OS=Homo sapiens OX=9606 GN=PLCB4 PE=1 SV=3",0,33.055,9,9,20,9,1175,134.4,6.9,9162,,9,,metabolic process;regulation of biological process;response to stimulus,cytosol;endoplasmic reticulum;nucleus,catalytic activity;metal ion binding;motor activity;protein binding;signal transducer activity,"Pf00168, Pf00387, Pf00388, Pf01576, Pf02463, Pf06631, Pf08703, Pf09279, Pf12474",5332,ENSG00000101333.16,PLCB4,20,Circadian entrainment; Alzheimer's disease; cGMP-PKG signaling pathway; Glucagon signaling pathway; Estrogen signaling pathway; NOD-like receptor signaling pathway; Phosphatidylinositol signaling system; Inflammatory mediator regulation of TRP channels; Pathways in cancer; Aldosterone synthesis and secretion; Rap1 signaling pathway; Melanogenesis; African trypanosomiasis; Glutamatergic synapse; AGE-RAGE signaling pathway in diabetic complications; Metabolic pathways; Serotonergic synapse; Insulin secretion; Gastric acid secretion; Renin secretion; Thyroid hormone synthesis; Cholinergic synapse; Dopaminergic synapse; Long-term potentiation; Retrograde endocannabinoid signaling; Phospholipase D signaling pathway; Inositol phosphate metabolism; Chemokine signaling pathway; Endocrine and other factor-regulated calcium reabsorption; Long-term depression; Vascular smooth muscle contraction; Adrenergic signaling in cardiomyocytes; GnRH signaling pathway; Oxytocin signaling pathway; Wnt signaling pathway; Platelet activation; Amoebiasis; Gap junction; Salivary secretion; Huntington's disease; Pancreatic secretion; Calcium signaling pathway; Chagas disease (American trypanosomiasis); Thyroid hormone signaling pathway; Sphingolipid signaling pathway,Alzheimers Disease; Chemokine signaling pathway,PLC beta mediated events; Synthesis of IP3 and IP4 in the cytosol; Gastrin-CREB signalling pathway via PKC and MAPK,58,High,1
Q13361,Microfibrillar-associated protein 5 OS=Homo sapiens OX=9606 GN=MFAP5 PE=1 SV=1,0,33.037,23,5,135,5,173,19.6,5.94,55268,,5,,cell organization and biogenesis,extracellular,structural molecule activity,Pf05507,8076,ENSG00000197614.10,MFAP5,12,,MFAP5-mediated ovarian cancer cell motility and invasiveness,Molecules associated with elastic fibres,4,High,1
Q8TED9,Actin filament-associated protein 1-like 1 OS=Homo sapiens OX=9606 GN=AFAP1L1 PE=1 SV=2,0,33.016,15,7,21,7,768,86.4,6.8,5620,5.2,7,1,,cytoplasm,protein binding,Pf00169,134265,ENSG00000157510.13,AFAP1L1,5,,,,0,High,1
O14791,Apolipoprotein L1 OS=Homo sapiens OX=9606 GN=APOL1 PE=1 SV=5,0,33.01,10,4,99,4,398,43.9,5.81,37965,,4,,defense response;metabolic process;response to stimulus;transport,extracellular;organelle lumen,protein binding;transporter activity,Pf05461,8542,ENSG00000100342.20,APOL1,22,African trypanosomiasis,,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Scavenging of heme from plasma,8,High,1
Q9BQE5,Apolipoprotein L2 OS=Homo sapiens OX=9606 GN=APOL2 PE=1 SV=1,0,32.959,16,5,30,5,337,37.1,6.74,11997,3.65,5,2,defense response;development;metabolic process;response to stimulus;transport,cytoplasm;extracellular;membrane,protein binding,Pf05461,23780,,APOL2,22,,,,0,High,1
Q9UM22,Mammalian ependymin-related protein 1 OS=Homo sapiens OX=9606 GN=EPDR1 PE=1 SV=2,0,32.898,24,5,93,5,224,25.4,6.6,43618,,5,,,extracellular;vacuole,metal ion binding,Pf00811,54749,ENSG00000086289.11,EPDR1,7,,,,0,High,1
P20645,Cation-dependent mannose-6-phosphate receptor OS=Homo sapiens OX=9606 GN=M6PR PE=1 SV=1,0,32.893,12,2,31,2,277,31,5.83,15130,,2,,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,endosome;membrane;vacuole,protein binding;receptor activity;signal transducer activity;transporter activity,Pf02157,4074,ENSG00000003056.7,M6PR,12,Phagosome; Lysosome,,Cargo recognition for clathrin-mediated endocytosis; Retrograde transport at the Trans-Golgi-Network; Lysosome Vesicle Biogenesis,11,High,1
Q96KG9,N-terminal kinase-like protein OS=Homo sapiens OX=9606 GN=SCYL1 PE=1 SV=1,0,32.844,14,8,23,8,808,89.6,6.3,8479,,8,,metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;Golgi;membrane;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding,"Pf00069, Pf07714",57410,ENSG00000142186.16,SCYL1,11,,,,0,High,1
Q9UBQ5,Eukaryotic translation initiation factor 3 subunit K OS=Homo sapiens OX=9606 GN=EIF3K PE=1 SV=1,0,32.83,32,6,57,6,218,25,4.93,26857,2,6,2,metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;nucleus,protein binding;RNA binding,"Pf03399, Pf10075",27335,ENSG00000282986.1; ENSG00000178982.9,EIF3K,19; CHR_HG26_PATCH,,,"Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Ribosomal scanning and start codon recognition",11,High,1
P04271,Protein S100-B OS=Homo sapiens OX=9606 GN=S100B PE=1 SV=2,0,32.819,40,2,44,2,92,10.7,4.59,19531,,2,,cell differentiation;cell organization and biogenesis;cell proliferation;defense response;regulation of biological process;response to stimulus,cytoplasm;extracellular;nucleus,metal ion binding;protein binding,Pf01023,6285,ENSG00000160307.9,S100B,21,,,TRAF6 mediated NF-kB activation; Advanced glycosylation endproduct receptor signaling; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; RIP-mediated NFkB activation via ZBP1; Activated TLR4 signalling; Interleukin-1 family signaling; DEx/H-box helicases activate type I IFN and inflammatory cytokines production ; Nuclear signaling by ERBB4,34,High,1
Q8NBM8,Prenylcysteine oxidase-like OS=Homo sapiens OX=9606 GN=PCYOX1L PE=1 SV=2,0,32.815,11,4,30,4,494,54.6,7.31,11269,,4,,metabolic process;transport,extracellular;membrane;organelle lumen,catalytic activity,"Pf01593, Pf07156",78991,ENSG00000145882.10,PCYOX1L,5,,,Platelet degranulation,4,High,1
Q8IYS2,Uncharacterized protein KIAA2013 OS=Homo sapiens OX=9606 GN=KIAA2013 PE=1 SV=1,0,32.802,8,4,24,4,634,69.1,8.19,10645,,4,,,membrane,,Pf10222,90231,ENSG00000116685.15,KIAA2013,1,,,,0,High,1
Q03169,Tumor necrosis factor alpha-induced protein 2 OS=Homo sapiens OX=9606 GN=TNFAIP2 PE=2 SV=2,0,32.797,19,8,24,8,654,72.6,6.46,9956,,8,,cell differentiation;development;transport,,protein binding,Pf06046,7127,ENSG00000185215.8,TNFAIP2,14,,,,0,High,1
P00746,Complement factor D OS=Homo sapiens OX=9606 GN=CFD PE=1 SV=5,0,32.779,28,4,32,4,253,27,7.71,14833,10.17,4,1,defense response;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;organelle lumen,catalytic activity,"Pf00089, Pf09342, Pf13365",1675,ENSG00000274619.2; ENSG00000197766.7,CFD,19; CHR_HSCHR19_5_CTG2,Staphylococcus aureus infection; Complement and coagulation cascades,Adipogenesis; Complement Activation; Complement and Coagulation Cascades,Platelet degranulation ; Alternative complement activation; Neutrophil degranulation,15,High,1
Q6NUQ1,RAD50-interacting protein 1 OS=Homo sapiens OX=9606 GN=RINT1 PE=1 SV=1,0,32.749,9,5,20,5,792,90.6,5.45,10781,,5,,regulation of biological process;transport,cytoplasm;cytosol;endoplasmic reticulum;membrane,protein binding,Pf04437,60561,ENSG00000135249.7,RINT1,7,,,COPI-dependent Golgi-to-ER retrograde traffic,5,High,1
Q9Y6P5-2,Isoform T1 of Sestrin-1 OS=Homo sapiens OX=9606 GN=SESN1,0,32.681,12,6,28,6,551,63.8,6.3,7903,9.75,5,2,cell communication;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,antioxidant activity;catalytic activity;protein binding,Pf04636,27244,ENSG00000080546.13,SESN1,6,,miRNA Regulation of DNA Damage Response; Mesodermal Commitment Pathway; DNA Damage Response,,3,High,1
Q32NB8,"CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=PGS1 PE=2 SV=1",0,32.675,16,8,21,8,556,62.7,8.9,7984,,8,,metabolic process,endoplasmic reticulum;membrane;mitochondrion,catalytic activity;metal ion binding;nucleotide binding,,9489,ENSG00000087157.18,PGS1,17,Metabolic pathways; Glycerophospholipid metabolism,,Synthesis of PG,7,High,1
Q8IWB1,"Inositol 1,4,5-trisphosphate receptor-interacting protein OS=Homo sapiens OX=9606 GN=ITPRIP PE=1 SV=1",0,32.659,15,7,24,7,547,62,5.88,10413,,7,,,membrane,,Pf03281,85450,ENSG00000148841.15,ITPRIP,10,,,,0,High,1
Q92556,Engulfment and cell motility protein 1 OS=Homo sapiens OX=9606 GN=ELMO1 PE=1 SV=2,0,32.652,15,8,32,6,727,83.8,6.28,12035,,8,,cell death;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane,protein binding,"Pf04727, Pf11841",9844,ENSG00000155849.15,ELMO1,7,Shigellosis; Chemokine signaling pathway; Bacterial invasion of epithelial cells,Chemokine signaling pathway,"Regulation of actin dynamics for phagocytic cup formation; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; VEGFA-VEGFR2 Pathway; Nef and signal transduction",21,High,1
B0YJ81,Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 OS=Homo sapiens OX=9606 GN=HACD1 PE=1 SV=1,0,32.643,14,3,41,3,288,32.4,9.04,17825,6.88,3,1,cell organization and biogenesis;development;metabolic process;regulation of biological process,endoplasmic reticulum;membrane,catalytic activity;protein binding,Pf04387,9200,ENSG00000165996.13,PTPLA; HACD1,10,Fatty acid elongation; Fatty acid metabolism; Biosynthesis of unsaturated fatty acids,,Synthesis of very long-chain fatty acyl-CoAs,8,High,1
Q99985,Semaphorin-3C OS=Homo sapiens OX=9606 GN=SEMA3C PE=2 SV=2,0,32.599,12,9,53,8,751,85.2,8.69,23750,,9,,cell differentiation;cellular component movement;development;regulation of biological process;response to stimulus,extracellular;membrane,protein binding,"Pf01403, Pf01437, Pf07679",10512,ENSG00000075223.13,SEMA3C,7,Axon guidance,,,1,High,1
Q9Y3E5,"Peptidyl-tRNA hydrolase 2, mitochondrial OS=Homo sapiens OX=9606 GN=PTRH2 PE=1 SV=1",0,32.589,32,3,42,3,179,19.2,8.73,21372,,3,,cell death;regulation of biological process,cytosol;membrane;mitochondrion,catalytic activity;protein binding,Pf01981,51651,ENSG00000141378.14,PTRH2,17,,,Ub-specific processing proteases,4,High,1
P61769,Beta-2-microglobulin OS=Homo sapiens OX=9606 GN=B2M PE=1 SV=1,0,32.555,35,4,81,4,119,13.7,6.52,35738,4.18,3,1,cell differentiation;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytosol;extracellular;Golgi;membrane;organelle lumen,protein binding,Pf07654,567,ENSG00000273686.4; ENSG00000166710.17,B2M,15; CHR_HSCHR15_3_CTG8,Antigen processing and presentation,,"DAP12 signaling; Neutrophil degranulation; Endosomal/Vacuolar pathway; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Interferon gamma signaling; Amyloid fiber formation; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; ER-Phagosome pathway; Nef mediated downregulation of MHC class I complex cell surface expression",25,High,1
Q01081,Splicing factor U2AF 35 kDa subunit OS=Homo sapiens OX=9606 GN=U2AF1 PE=1 SV=3,0,32.552,17,4,35,4,240,27.9,8.81,17196,,4,,metabolic process;regulation of biological process;transport,nucleus;spliceosomal complex,metal ion binding;protein binding;RNA binding,"Pf00076, Pf00642, Pf13893",7307; 102724594,ENSG00000160201.11; ENSG00000275895.6,U2AF1; LOC102724594; U2AF1L5,21,Shigellosis; Spliceosome,mRNA Processing,Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway,14,High,1
Q96D71,RalBP1-associated Eps domain-containing protein 1 OS=Homo sapiens OX=9606 GN=REPS1 PE=1 SV=3,0,32.512,12,7,36,7,796,86.6,5.69,12509,,7,,cell organization and biogenesis;transport,cytosol;membrane,metal ion binding;protein binding,"Pf12763, Pf13499",85021,ENSG00000135597.18,REPS1,6,,,Cargo recognition for clathrin-mediated endocytosis,4,High,1
Q9BQ67,Glutamate-rich WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=GRWD1 PE=1 SV=1,0,32.495,16,4,15,4,446,49.4,4.92,5848,,4,,cell organization and biogenesis;metabolic process,chromosome;cytosol;nucleus,DNA binding;protein binding;RNA binding,"Pf00400, Pf12265",83743,ENSG00000105447.12,GRWD1,19,,,,0,High,1
P16885,"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 OS=Homo sapiens OX=9606 GN=PLCG2 PE=1 SV=4",0,32.477,8,9,20,9,1265,147.8,6.64,8956,,9,,cell differentiation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;membrane,catalytic activity;protein binding;signal transducer activity,"Pf00017, Pf00018, Pf00168, Pf00387, Pf00388, Pf07653, Pf09279, Pf14604",5336,ENSG00000197943.9,PLCG2,16,NF-kappa B signaling pathway; ErbB signaling pathway; Metabolic pathways; B cell receptor signaling pathway; Inflammatory mediator regulation of TRP channels; HIF-1 signaling pathway; Inositol phosphate metabolism; Glioma; Calcium signaling pathway; Non-small cell lung cancer; Ras signaling pathway; Epstein-Barr virus infection; Leukocyte transendothelial migration; Pathways in cancer; Epithelial cell signaling in Helicobacter pylori infection; MicroRNAs in cancer; EGFR tyrosine kinase inhibitor resistance; Natural killer cell mediated cytotoxicity; Fc gamma R-mediated phagocytosis; Osteoclast differentiation; AGE-RAGE signaling pathway in diabetic complications; VEGF signaling pathway; Vibrio cholerae infection; Phosphatidylinositol signaling system; Platelet activation; Neurotrophin signaling pathway; Fc epsilon RI signaling pathway; Thyroid hormone signaling pathway; Axon guidance; Phospholipase D signaling pathway; Proteoglycans in cancer,Leptin signaling pathway; Signaling Pathways in Glioblastoma; B Cell Receptor Signaling Pathway; Corticotropin-releasing hormone signaling pathway; Myometrial Relaxation and Contraction Pathways; Microglia Pathogen Phagocytosis Pathway; GPR40 PATHWAY,DAP12 signaling; FCERI mediated Ca+2 mobilization; Synthesis of IP3 and IP4 in the cytosol; Toll Like Receptor 4 (TLR4) Cascade; GPVI-mediated activation cascade; Dectin-2 family; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; FCERI mediated MAPK activation; CLEC7A (Dectin-1) signaling; Role of phospholipids in phagocytosis,61,High,1
Q96EL3,"39S ribosomal protein L53, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL53 PE=1 SV=1",0,32.472,41,4,57,4,112,12.1,8.76,20899,,4,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,protein binding,Pf10780,116540,ENSG00000204822.6,MRPL53,2,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
Q5T0D9,Tumor protein p63-regulated gene 1-like protein OS=Homo sapiens OX=9606 GN=TPRG1L PE=1 SV=1,0,32.446,37,5,18,5,272,30.2,7.34,7275,,5,,,membrane,protein binding,Pf12456,127262,ENSG00000158109.14,TPRG1L,1,,,,0,High,1
O14662,Syntaxin-16 OS=Homo sapiens OX=9606 GN=STX16 PE=1 SV=3,0,32.445,29,5,18,5,325,37,6.11,9395,,5,,cell organization and biogenesis;transport,cytoplasm;cytosol;endoplasmic reticulum;Golgi;membrane,protein binding,"Pf00804, Pf05739",8675,ENSG00000124222.22,STX16,20,SNARE interactions in vesicular transport,Ectoderm Differentiation,Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network,7,High,1
P53999,Activated RNA polymerase II transcriptional coactivator p15 OS=Homo sapiens OX=9606 GN=SUB1 PE=1 SV=3,0,32.442,38,6,85,6,127,14.4,9.6,34504,,6,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,nucleus,catalytic activity;DNA binding;protein binding;RNA binding,Pf02229,10923,ENSG00000113387.11,SUB1,5,,,,0,High,1
Q71UM5,40S ribosomal protein S27-like OS=Homo sapiens OX=9606 GN=RPS27L PE=1 SV=3,0,32.428,30,3,70,2,84,9.5,9.45,33985,2.08,3,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,nucleus;ribosome,enzyme regulator activity;metal ion binding;protein binding;RNA binding;structural molecule activity;translation regulator activity,Pf01667,51065,ENSG00000185088.13,RPS27L,15,Ribosome,,"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane",37,High,1
Q96BP2,Coiled-coil-helix-coiled-coil-helix domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CHCHD1 PE=1 SV=1,0,32.426,33,4,62,4,118,13.5,10.21,25985,0,4,1,cell organization and biogenesis;metabolic process,cytosol;membrane;mitochondrion;nucleus;ribosome,protein binding;RNA binding,Pf06747,118487,ENSG00000172586.7,CHCHD1,10,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
Q53S33,BolA-like protein 3 OS=Homo sapiens OX=9606 GN=BOLA3 PE=1 SV=1,0,32.393,23,4,115,4,107,12.1,9.64,52992,,4,,,mitochondrion,,Pf01722,388962,ENSG00000163170.11,BOLA3,2,,,,0,High,1
Q8N4P3,"Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 OS=Homo sapiens OX=9606 GN=HDDC3 PE=1 SV=3",0,32.38,38,5,22,5,179,20.3,6.74,11410,,5,,,,catalytic activity;metal ion binding;protein binding,Pf13328,374659,ENSG00000184508.10,HDDC3,15,Purine metabolism,,,1,High,1
Q8N3F8,MICAL-like protein 1 OS=Homo sapiens OX=9606 GN=MICALL1 PE=1 SV=2,0,32.379,11,7,26,7,863,93.4,7.25,10014,,7,,cell organization and biogenesis;response to stimulus;transport,endosome;membrane,metal ion binding;protein binding,"Pf00307, Pf11971, Pf12130",85377,ENSG00000100139.13,MICALL1,22,,,,0,High,1
Q92604,Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 OS=Homo sapiens OX=9606 GN=LPGAT1 PE=1 SV=1,0,32.322,20,7,32,7,370,43.1,8.92,11298,,7,,metabolic process;regulation of biological process,cytoplasm;endoplasmic reticulum;membrane,catalytic activity,Pf01553,9926,ENSG00000123684.12,LPGAT1,1,Glycerophospholipid metabolism,,Acyl chain remodelling of PG,6,High,1
Q70E73,Ras-associated and pleckstrin homology domains-containing protein 1 OS=Homo sapiens OX=9606 GN=RAPH1 PE=1 SV=3,0,32.301,7,7,15,7,1250,135.2,8.85,6124,,7,,cell growth;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane,protein binding,"Pf00169, Pf00788",65059,ENSG00000173166.17,RAPH1,2,,,,0,High,1
Q6SZW1,Sterile alpha and TIR motif-containing protein 1 OS=Homo sapiens OX=9606 GN=SARM1 PE=1 SV=1,0,32.28,12,5,18,5,724,79.3,6.55,8856,,5,,cell differentiation;defense response;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;mitochondrion,protein binding,"Pf00536, Pf07647, Pf13676",23098,ENSG00000004139.13,SARM1,17,,Regulation of toll-like receptor signaling pathway,Toll Like Receptor 3 (TLR3) Cascade; TRAF6-mediated induction of TAK1 complex within TLR4 complex; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; IKK complex recruitment mediated by RIP1; Activated TLR4 signalling,12,High,1
P57088,Transmembrane protein 33 OS=Homo sapiens OX=9606 GN=TMEM33 PE=1 SV=2,0,32.262,22,7,91,7,247,28,9.7,43364,,7,,cell organization and biogenesis;regulation of biological process;response to stimulus,endoplasmic reticulum;membrane;nucleus,protein binding;structural molecule activity,Pf03661,55161,ENSG00000109133.12,TMEM33,4,,,,0,High,1
Q9UH90,F-box only protein 40 OS=Homo sapiens OX=9606 GN=FBXO40 PE=2 SV=2,0,32.214,12,6,25,6,709,79.7,7.11,,42.69,,6,cell differentiation;metabolic process,cytoplasm;cytosol,catalytic activity;metal ion binding;protein binding,,51725,ENSG00000163833.7,FBXO40,3,,,Antigen processing: Ubiquitination & Proteasome degradation; Neddylation,7,High,1
O75438,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 OS=Homo sapiens OX=9606 GN=NDUFB1 PE=1 SV=1,0,32.16,34,3,169,3,58,7,8.92,93133,0,3,1,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion,catalytic activity,Pf08040,4707,ENSG00000183648.9,NDUFB1,14,Alzheimer's disease; Oxidative phosphorylation; Non-alcoholic fatty liver disease (NAFLD); Huntington's disease; Metabolic pathways; Parkinson's disease,Electron Transport Chain; Oxidative phosphorylation,Complex I biogenesis,13,High,1
Q86V21,Acetoacetyl-CoA synthetase OS=Homo sapiens OX=9606 GN=AACS PE=1 SV=1,0,32.15,13,9,27,9,672,75.1,6.24,10468,0,9,1,cell differentiation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,catalytic activity;nucleotide binding;protein binding,Pf00501,65985,ENSG00000081760.16,AACS,12,"Butanoate metabolism; Valine, leucine and isoleucine degradation",,Synthesis of Ketone Bodies,6,High,1
Q9HCG7,Non-lysosomal glucosylceramidase OS=Homo sapiens OX=9606 GN=GBA2 PE=1 SV=2,0,32.142,13,9,24,9,927,104.6,5.92,8070,,9,,metabolic process,endoplasmic reticulum;Golgi;membrane,catalytic activity,"Pf04685, Pf12215",57704,ENSG00000070610.14,GBA2,9,Sphingolipid metabolism; Metabolic pathways; Other glycan degradation,,Glycosphingolipid metabolism,7,High,1
Q7L5N7,Lysophosphatidylcholine acyltransferase 2 OS=Homo sapiens OX=9606 GN=LPCAT2 PE=1 SV=1,0,32.127,18,8,35,8,544,60.2,6.55,13218,,8,,cell organization and biogenesis;metabolic process,endoplasmic reticulum;Golgi;membrane,catalytic activity;metal ion binding,"Pf00036, Pf01553, Pf04760, Pf13202, Pf13405, Pf13499, Pf13833",54947,ENSG00000087253.12,LPCAT2,16,Ether lipid metabolism; Metabolic pathways; Glycerophospholipid metabolism,,Acyl chain remodelling of PC,8,High,1
Q9Y312,Protein AAR2 homolog OS=Homo sapiens OX=9606 GN=AAR2 PE=1 SV=2,0,32.124,22,6,19,6,384,43.4,5.96,8285,,6,,cell organization and biogenesis;metabolic process,spliceosomal complex,,Pf05282,25980,ENSG00000131043.11,AAR2,20,,,,0,High,1
P42574,Caspase-3 OS=Homo sapiens OX=9606 GN=CASP3 PE=1 SV=2,0,32.121,29,7,44,7,277,31.6,6.54,18852,,7,,cell death;cell differentiation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,catalytic activity;enzyme regulator activity;protein binding,Pf00656,836,ENSG00000164305.18,CASP3,4,Serotonergic synapse; Parkinson's disease; Tuberculosis; Colorectal cancer; Viral myocarditis; Hepatitis B; p53 signaling pathway; Toxoplasmosis; Apoptosis - multiple species; Platinum drug resistance; Huntington's disease; Herpes simplex infection; Amoebiasis; Proteoglycans in cancer; Natural killer cell mediated cytotoxicity; Epithelial cell signaling in Helicobacter pylori infection; Viral carcinogenesis; Apoptosis; MAPK signaling pathway; Amyotrophic lateral sclerosis (ALS); Pertussis; MicroRNAs in cancer; Non-alcoholic fatty liver disease (NAFLD); AGE-RAGE signaling pathway in diabetic complications; TNF signaling pathway; Alzheimer's disease; Pathways in cancer; Legionellosis,miRNA Regulation of DNA Damage Response; Integrated Breast Cancer Pathway; Prolactin Signaling Pathway; Alzheimers Disease; TNF alpha Signaling Pathway; AGE/RAGE pathway; Allograft Rejection; Corticotropin-releasing hormone signaling pathway; Parkinsons Disease Pathway; Oncostatin M Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Spinal Cord Injury; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation; Copper homeostasis; Hepatitis C and Hepatocellular Carcinoma; MAPK Signaling Pathway; Apoptosis Modulation by HSP70; ERK Pathway in Huntington's Disease; Oxidative Damage; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways; DNA Damage Response,Ligand-independent caspase activation via DCC; Signaling by Hippo; SMAC-mediated dissociation of IAP:caspase complexes ; SMAC binds to IAPs ; Stimulation of the cell death response by PAK-2p34; Caspase-mediated cleavage of cytoskeletal proteins; NADE modulates death signalling; Other interleukin signaling; Degradation of the extracellular matrix; Activation of DNA fragmentation factor; Apoptotic cleavage of cell adhesion  proteins; Activation of caspases through apoptosome-mediated cleavage; Signalling by NGF,83,High,1
Q9H074,Polyadenylate-binding protein-interacting protein 1 OS=Homo sapiens OX=9606 GN=PAIP1 PE=1 SV=1,0,32.107,26,8,47,8,479,53.5,4.81,18587,,8,,metabolic process;regulation of biological process,cytoplasm;cytosol,protein binding;RNA binding;translation regulator activity,Pf02854,10605,ENSG00000172239.13,PAIP1,5,RNA transport,Translation Factors,Deadenylation of mRNA,5,High,1
Q96B36,Proline-rich AKT1 substrate 1 OS=Homo sapiens OX=9606 GN=AKT1S1 PE=1 SV=1,0,32.082,27,5,36,5,256,27.4,4.75,19411,,5,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,protein binding,,84335,ENSG00000204673.10,AKT1S1,19,AMPK signaling pathway; mTOR signaling pathway; Longevity regulating pathway; Longevity regulating pathway - multiple species,Target Of Rapamycin (TOR) Signaling; VEGFA-VEGFR2 Signaling Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Senescence and Autophagy in Cancer,HSF1-dependent transactivation; AKT phosphorylates targets in the cytosol; mTORC1-mediated signalling; Constitutive Signaling by AKT1 E17K in Cancer,22,High,1
Q8TC12,Retinol dehydrogenase 11 OS=Homo sapiens OX=9606 GN=RDH11 PE=1 SV=2,0,32.082,23,5,34,5,318,35.4,8.82,16592,0,5,1,metabolic process,endoplasmic reticulum;membrane,catalytic activity,"Pf00106, Pf00670, Pf08659, Pf13460",51109,ENSG00000072042.12,RDH11,14,Metabolic pathways; Retinol metabolism,,Signaling by GPCR; The canonical retinoid cycle in rods (twilight vision); RA biosynthesis pathway; Retinoid metabolism and transport,13,High,1
P17677,Neuromodulin OS=Homo sapiens OX=9606 GN=GAP43 PE=1 SV=1,0,32.069,37,4,10,4,238,24.8,4.72,5418,,4,,cell differentiation;cell organization and biogenesis;cellular component movement;development;regulation of biological process;response to stimulus,cytoplasm;membrane,protein binding,"Pf00612, Pf10580",2596,ENSG00000172020.12,GAP43,3,,Glial Cell Differentiation; Spinal Cord Injury,L1CAM interactions,5,High,1
Q9NR30,Nucleolar RNA helicase 2 OS=Homo sapiens OX=9606 GN=DDX21 PE=1 SV=5,0,32.039,14,8,37,5,783,87.3,9.28,13243,,8,,cell differentiation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;membrane;nucleus,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00270, Pf00271, Pf08152, Pf14617",9188,ENSG00000165732.12,DDX21,10,,,Major pathway of rRNA processing in the nucleolus and cytosol; B-WICH complex positively regulates rRNA expression,8,High,1
Q6GQQ9,OTU domain-containing protein 7B OS=Homo sapiens OX=9606 GN=OTUD7B PE=1 SV=1,0,32.036,8,5,25,5,843,92.5,6.71,11727,0,5,1,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;DNA binding;metal ion binding;protein binding,"Pf01754, Pf02338, Pf14555",56957,ENSG00000264522.5,OTUD7B,1,,TNF alpha Signaling Pathway,Regulation of TNFR1 signaling; Ovarian tumor domain proteases; TNFR1-induced NFkappaB signaling pathway; TNFR1-induced proapoptotic signaling,11,High,1
O00339,Matrilin-2 OS=Homo sapiens OX=9606 GN=MATN2 PE=1 SV=4,0,32.029,9,6,33,6,956,106.8,6.27,11511,,6,,cell organization and biogenesis;cellular component movement;response to stimulus,extracellular,metal ion binding;protein binding,"Pf00092, Pf03302, Pf07645, Pf10393, Pf12662, Pf12947, Pf13519, Pf14670",4147,ENSG00000132561.13,MATN2,8,,,,0,High,1
Q7Z4G4,tRNA (guanine(10)-N2)-methyltransferase homolog OS=Homo sapiens OX=9606 GN=TRMT11 PE=1 SV=1,0,32.025,16,5,16,5,463,53.4,7.78,6411,,5,,metabolic process;regulation of biological process,,catalytic activity;DNA binding;RNA binding,"Pf01170, Pf01555, Pf02384, Pf06325, Pf09445, Pf13659",60487,ENSG00000066651.18,TRMT11,6,,,tRNA modification in the nucleus and cytosol,3,High,1
Q969H8,Myeloid-derived growth factor OS=Homo sapiens OX=9606 GN=MYDGF PE=1 SV=1,0,31.973,29,4,40,4,173,18.8,6.68,16624,,4,,cell death;regulation of biological process,extracellular;organelle lumen,protein binding,Pf10572,56005,ENSG00000074842.7,C19orf10; MYDGF,19,,,XBP1(S) activates chaperone genes,4,High,1
Q6ZS17,Rho family-interacting cell polarization regulator 1 OS=Homo sapiens OX=9606 GN=RIPOR1 PE=1 SV=1,0,31.962,6,7,23,7,1223,132.2,6.28,9188,,7,,cell communication;regulation of biological process;response to stimulus,cytoplasm;Golgi;membrane,protein binding,Pf13646,79567,ENSG00000039523.19,FAM65A; RIPOR1,16,,,,0,High,1
P61601,Neurocalcin-delta OS=Homo sapiens OX=9606 GN=NCALD PE=1 SV=2,0,31.956,42,6,41,4,193,22.2,5.35,20724,,6,,regulation of biological process;response to stimulus;transport,cytosol,metal ion binding;protein binding;transporter activity,"Pf00036, Pf13202, Pf13405, Pf13499, Pf13833",83988,ENSG00000104490.17,NCALD,8,Olfactory transduction,,Activation of Ca-permeable Kainate Receptor,7,High,1
P19013,"Keratin, type II cytoskeletal 4 OS=Homo sapiens OX=9606 GN=KRT4 PE=1 SV=4",0,31.932,6,5,242,1,534,57.3,6.61,128567,,5,,cell death;cell differentiation;cell organization and biogenesis;regulation of biological process,cell surface;cytoskeleton;cytosol;nucleus,protein binding;structural molecule activity,"Pf00038, Pf10234, Pf13166",3851,,KRT4,12,,,Formation of the cornified envelope,3,High,1
P14136,Glial fibrillary acidic protein OS=Homo sapiens OX=9606 GN=GFAP PE=1 SV=1,0,31.918,7,5,472,1,432,49.9,5.52,260501,,5,,cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane;vacuole,catalytic activity;motor activity;protein binding;structural molecule activity;transporter activity,"Pf00038, Pf01496, Pf01576, Pf04732, Pf05761, Pf12128, Pf13270",2670,ENSG00000131095.12,GFAP,17,Jak-STAT signaling pathway,Neural Crest Differentiation; Spinal Cord Injury,Nuclear signaling by ERBB4,7,High,1
Q9UPU9,Protein Smaug homolog 1 OS=Homo sapiens OX=9606 GN=SAMD4A PE=1 SV=3,0,31.89,12,6,26,6,718,79.4,8.32,8736,0,5,1,metabolic process;regulation of biological process,cytoplasm;cytosol,protein binding;RNA binding;translation regulator activity,"Pf00536, Pf07647",23034,ENSG00000020577.13,SAMD4A,14,,,,0,High,1
P42898,Methylenetetrahydrofolate reductase OS=Homo sapiens OX=9606 GN=MTHFR PE=1 SV=3,0,31.882,13,7,19,7,656,74.5,5.34,7221,,7,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytosol,catalytic activity;nucleotide binding;protein binding,Pf02219,4524,ENSG00000177000.10,MTHFR,1,Antifolate resistance; Metabolic pathways; One carbon pool by folate; Carbon metabolism,Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate-Alcohol and Cancer Pathway; Fluoropyrimidine Activity; Folate Metabolism; One carbon donor; One Carbon Metabolism; Trans-sulfuration and one carbon metabolism; One carbon metabolism and related pathways,Metabolism of folate and pterines,17,High,1
Q7Z7F7,"39S ribosomal protein L55, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL55 PE=1 SV=1",0,31.88,30,4,48,4,128,15.1,11.15,21732,,4,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,structural molecule activity,Pf09776,128308,ENSG00000162910.18,MRPL55,1,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
Q9ULZ3,Apoptosis-associated speck-like protein containing a CARD OS=Homo sapiens OX=9606 GN=PYCARD PE=1 SV=2,0,31.87,39,6,16,6,195,21.6,6.34,8341,,6,,cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;extracellular;mitochondrion;nucleus;organelle lumen,catalytic activity;enzyme regulator activity;protein binding,"Pf00619, Pf02758",29108,ENSG00000103490.13,PYCARD,16,Legionellosis; NOD-like receptor signaling pathway; Salmonella infection; Pertussis; Influenza A; Cytosolic DNA-sensing pathway,Nucleotide-binding Oligomerization Domain (NOD) pathway; TYROBP Causal Network,CLEC7A/inflammasome pathway; The NLRP3 inflammasome; The AIM2 inflammasome; Neutrophil degranulation,18,High,1
Q4KMP7,TBC1 domain family member 10B OS=Homo sapiens OX=9606 GN=TBC1D10B PE=1 SV=3,0,31.868,11,6,33,6,808,87.1,9.19,12868,,6,,regulation of biological process;transport,cytoplasm;cytosol;membrane,enzyme regulator activity;protein binding,Pf00566,26000,ENSG00000169221.13,TBC1D10B,16,,,TBC/RABGAPs,4,High,1
O14530,Thioredoxin domain-containing protein 9 OS=Homo sapiens OX=9606 GN=TXNDC9 PE=1 SV=2,0,31.772,22,5,45,5,226,26.5,5.88,20318,,5,,cellular homeostasis;metabolic process;regulation of biological process,cytoplasm;cytoskeleton;nucleus,catalytic activity;protein binding,Pf00085,10190,ENSG00000115514.11,TXNDC9,2,,,,0,High,1
P01602,Immunoglobulin kappa variable 1-5 OS=Homo sapiens OX=9606 GN=IGKV1-5 PE=1 SV=2,0,31.732,31,3,26,3,117,12.8,8.28,10888,,3,,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity,"Pf00047, Pf07679, Pf07686, Pf13927",28299,ENSG00000282801.1; ENSG00000243466.1,IGKV1-5,2; CHR_HG2290_PATCH,,,FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis,26,High,1
Q9BXX0,EMILIN-2 OS=Homo sapiens OX=9606 GN=EMILIN2 PE=1 SV=3,0,31.729,9,7,48,7,1053,115.6,6.46,17521,,7,,,extracellular,protein binding;structural molecule activity,"Pf00386, Pf01391, Pf07546, Pf08317, Pf12128, Pf13514",84034,ENSG00000132205.10,EMILIN2,18,,,Molecules associated with elastic fibres,3,High,1
P14678,Small nuclear ribonucleoprotein-associated proteins B and B' OS=Homo sapiens OX=9606 GN=SNRPB PE=1 SV=2,0,31.725,33,7,75,7,240,24.6,11.19,34087,,7,,cell organization and biogenesis;metabolic process;transport,cytoplasm;cytosol;nucleus;spliceosomal complex,protein binding;RNA binding,Pf01423,6628,ENSG00000125835.18,SNRPB,20,Systemic lupus erythematosus; Spliceosome,mRNA Processing,SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; snRNP Assembly; Cleavage of Growing Transcript in the Termination Region,17,High,1
Q99489,D-aspartate oxidase OS=Homo sapiens OX=9606 GN=DDO PE=2 SV=1,0,31.71,30,6,38,6,341,37.5,7.91,16177,,6,,metabolic process;response to stimulus,organelle lumen,catalytic activity;nucleotide binding;protein binding,Pf01266,8528,,DDO,6,"Alanine, aspartate and glutamate metabolism; Peroxisome",,Glyoxylate metabolism and glycine degradation,5,High,1
Q9Y3L5,Ras-related protein Rap-2c OS=Homo sapiens OX=9606 GN=RAP2C PE=1 SV=1,0,31.709,49,8,54,2,183,20.7,4.94,23591,0,7,1,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane,catalytic activity;nucleotide binding,"Pf00009, Pf00071, Pf02421, Pf08477",57826,ENSG00000123728.9,RAP2C,X,,,Neutrophil degranulation,3,High,1
Q8IV38,Ankyrin repeat and MYND domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ANKMY2 PE=1 SV=1,0,31.703,15,5,36,5,441,49.3,6.25,12147,,5,,regulation of biological process,,metal ion binding;protein binding,"Pf00023, Pf01753, Pf12796, Pf13606, Pf13637, Pf13857",57037,ENSG00000106524.8,ANKMY2,7,,,,0,High,1
Q9HD15,Steroid receptor RNA activator 1 OS=Homo sapiens OX=9606 GN=SRA1 PE=1 SV=1,0,31.698,31,5,23,5,236,25.7,7.03,9827,,5,,cell death;cell differentiation;cell proliferation;metabolic process;regulation of biological process,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,protein binding;RNA binding,Pf07304,10011,ENSG00000213523.10,SRA1,5,,,,0,High,1
Q9BYF1,Angiotensin-converting enzyme 2 OS=Homo sapiens OX=9606 GN=ACE2 PE=1 SV=2,0,31.696,15,8,22,8,805,92.4,5.54,7569,,8,,metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;extracellular;membrane,catalytic activity;metal ion binding;protein binding;receptor activity,Pf01401,59272,ENSG00000130234.10,ACE2,X,Renin-angiotensin system; Protein digestion and absorption,ACE Inhibitor Pathway,Metabolism of Angiotensinogen to Angiotensins,6,High,1
Q01804,OTU domain-containing protein 4 OS=Homo sapiens OX=9606 GN=OTUD4 PE=1 SV=4,0,31.69,10,8,22,8,1114,124,6.71,7814,,8,,metabolic process,,catalytic activity;protein binding;RNA binding,"Pf02338, Pf10275",54726,ENSG00000164164.15,OTUD4,4,,,,0,High,1
Q9UGC7,"Peptide chain release factor 1-like, mitochondrial OS=Homo sapiens OX=9606 GN=MTRF1L PE=1 SV=1",0,31.689,26,7,22,6,380,43.6,8.34,9400,,7,,cell organization and biogenesis;metabolic process,cytoplasm;mitochondrion;organelle lumen,RNA binding,"Pf00472, Pf03462",54516,ENSG00000112031.15,MTRF1L,6,,,Mitochondrial translation termination,4,High,1
P49815,Tuberin OS=Homo sapiens OX=9606 GN=TSC2 PE=1 SV=2,0,31.681,6,9,29,9,1807,200.5,7.31,10719,,9,,cell death;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;Golgi;membrane;nucleus;vacuole,enzyme regulator activity;protein binding,"Pf02145, Pf03542, Pf11864",7249,ENSG00000103197.16,TSC2,16,Longevity regulating pathway; Choline metabolism in cancer; mTOR signaling pathway; Phospholipase D signaling pathway; PI3K-Akt signaling pathway; p53 signaling pathway; AMPK signaling pathway; Thyroid hormone signaling pathway; Insulin signaling pathway,AMP-activated Protein Kinase (AMPK) Signaling; Target Of Rapamycin (TOR) Signaling; Integrated Breast Cancer Pathway; Follicle Stimulating Hormone (FSH) signaling pathway; Signaling Pathways in Glioblastoma; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Nanoparticle triggered autophagic cell death; Wnt Signaling Pathway Netpath; BDNF-TrkB Signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; ATM Signaling Network in Development and Disease; Angiopoietin Like Protein 8 Regulatory Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Insulin Signaling; Monoamine Transport,AKT phosphorylates targets in the cytosol; Energy dependent regulation of mTOR by LKB1-AMPK; TBC/RABGAPs; TP53 Regulates Metabolic Genes; Macroautophagy; Inhibition of TSC complex formation by PKB; Constitutive Signaling by AKT1 E17K in Cancer,46,High,1
Q7KZ85,Transcription elongation factor SPT6 OS=Homo sapiens OX=9606 GN=SUPT6H PE=1 SV=2,0,31.669,5,8,24,8,1726,198.9,4.91,9742,,8,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,nucleus,DNA binding;protein binding;RNA binding,"Pf00017, Pf09371, Pf12836, Pf14633, Pf14635, Pf14639, Pf14641, Pf14878",6830,ENSG00000109111.14,SUPT6H,17,,,Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events,5,High,1
Q8N0X7,Spartin OS=Homo sapiens OX=9606 GN=SPART PE=1 SV=1,0,31.625,12,7,28,7,666,72.8,5.91,10794,,7,,cell division;cell organization and biogenesis;regulation of biological process,cytoplasm;cytosol;membrane,protein binding,"Pf04212, Pf06911",23111,ENSG00000133104.12,SPG20; SPART,13,Endocytosis,,,1,High,1
Q9Y5J7,Mitochondrial import inner membrane translocase subunit Tim9 OS=Homo sapiens OX=9606 GN=TIMM9 PE=1 SV=1,0,31.623,47,4,43,4,89,10.4,7.21,19069,,4,,cell organization and biogenesis;transport,membrane;mitochondrion,metal ion binding;protein binding;transporter activity,Pf02953,26520,ENSG00000100575.13,TIMM9,14,,,Mitochondrial protein import; Metabolism of proteins,2,High,1
O43633,Charged multivesicular body protein 2a OS=Homo sapiens OX=9606 GN=CHMP2A PE=1 SV=1,0,31.615,22,5,51,5,222,25.1,5.97,22404,1.72,5,1,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,chromosome;cytosol;endosome;membrane,protein binding,Pf03357,27243,ENSG00000130724.8,CHMP2A,19,Endocytosis,,Budding and maturation of HIV virion; Macroautophagy; Endosomal Sorting Complex Required For Transport (ESCRT); Lysosome Vesicle Biogenesis,15,High,1
P82914,"28S ribosomal protein S15, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS15 PE=1 SV=1",0,31.604,23,6,74,6,257,29.8,10.48,32770,0,6,1,cell organization and biogenesis;metabolic process,membrane;mitochondrion;nucleus;ribosome,RNA binding;structural molecule activity,Pf00312,64960,ENSG00000116898.11,MRPS15,1,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
Q13614,Myotubularin-related protein 2 OS=Homo sapiens OX=9606 GN=MTMR2 PE=1 SV=4,0,31.59,12,7,26,6,643,73.3,7.4,10390,,7,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;endosome;membrane;nucleus,catalytic activity;protein binding,"Pf02893, Pf06602",8898,ENSG00000087053.18,MTMR2,11,Metabolic pathways; Phosphatidylinositol signaling system; Inositol phosphate metabolism,,Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the ER membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane,11,High,1
O00291,Huntingtin-interacting protein 1 OS=Homo sapiens OX=9606 GN=HIP1 PE=1 SV=5,0,31.575,9,7,18,7,1037,116.1,5.3,6624,,7,,cell death;cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;Golgi;membrane;nucleus,catalytic activity;motor activity;protein binding;structural molecule activity,"Pf00038, Pf00529, Pf00769, Pf01417, Pf01576, Pf01608, Pf02463, Pf04111, Pf04156, Pf05557, Pf05622, Pf07227, Pf07321, Pf07651, Pf07888, Pf09726, Pf09730, Pf09731, Pf09787, Pf09789, Pf10174, Pf10186, Pf12072, Pf12128, Pf12795, Pf13514, Pf13851, Pf15112, Pf15619",3092,ENSG00000127946.16,HIP1,7,Huntington's disease,,Clathrin-mediated endocytosis,4,High,1
P11441,Ubiquitin-like protein 4A OS=Homo sapiens OX=9606 GN=UBL4A PE=1 SV=1,0,31.545,32,5,69,5,157,17.8,8.66,29371,0,5,1,metabolic process;transport,cytoplasm;cytosol;membrane;nucleus,catalytic activity;protein binding,"Pf00240, Pf09665, Pf11976",8266,ENSG00000102178.12,UBL4A,X,,,,0,High,1
P10114,Ras-related protein Rap-2a OS=Homo sapiens OX=9606 GN=RAP2A PE=1 SV=1,0,31.541,41,7,54,2,183,20.6,4.82,23663,,7,,cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus,cytosol;endosome;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00071, Pf02421, Pf08477",5911,ENSG00000125249.6,RAP2A,13,,,,0,High,1
Q96A72,Protein mago nashi homolog 2 OS=Homo sapiens OX=9606 GN=MAGOHB PE=1 SV=1,0,31.532,43,6,58,1,148,17.3,6.39,21223,1.89,6,1,metabolic process;transport,nucleus;spliceosomal complex,protein binding;RNA binding,Pf02792,55110,ENSG00000111196.9,MAGOHB,12,RNA transport; mRNA surveillance pathway; Spliceosome,,mRNA 3'-end processing; mRNA Splicing - Major Pathway; Cleavage of Growing Transcript in the Termination Region ; Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC),20,High,1
O75339,Cartilage intermediate layer protein 1 OS=Homo sapiens OX=9606 GN=CILP PE=1 SV=4,0,31.49,6,6,52,6,1184,132.5,8.41,20861,,6,,regulation of biological process,extracellular,catalytic activity;protein binding,"Pf00090, Pf03762, Pf07679, Pf13330, Pf13715, Pf13895, Pf13927",8483,ENSG00000138615.5,CILP,15,,,Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R),3,High,1
Q9NZR1,Tropomodulin-2 OS=Homo sapiens OX=9606 GN=TMOD2 PE=1 SV=1,0,31.468,27,7,26,7,351,39.6,5.27,10210,,7,,cell communication;cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton,protein binding,Pf03250,29767,ENSG00000128872.9,TMOD2,15,,,Striated Muscle Contraction,2,High,1
Q8IUX1,"Complex I assembly factor TMEM126B, mitochondrial OS=Homo sapiens OX=9606 GN=TMEM126B PE=1 SV=2",0,31.422,33,5,31,5,230,25.9,8.81,11495,,5,,cell organization and biogenesis,membrane;mitochondrion,protein binding,Pf07114,55863,ENSG00000171204.12,TMEM126B,11,,,Complex I biogenesis,5,High,1
P62910,60S ribosomal protein L32 OS=Homo sapiens OX=9606 GN=RPL32 PE=1 SV=2,0,31.393,30,5,194,5,135,15.9,11.33,86331,,5,,cell organization and biogenesis;metabolic process;response to stimulus;transport,cytosol;membrane;ribosome,RNA binding;structural molecule activity,Pf01655,6161,ENSG00000144713.12,RPL32,3,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
Q9UDX5,Mitochondrial fission process protein 1 OS=Homo sapiens OX=9606 GN=MTFP1 PE=1 SV=1,0,31.354,40,6,43,6,166,18,9.31,20531,,6,,cell death;cell organization and biogenesis;response to stimulus,membrane;mitochondrion,,Pf10558,51537,ENSG00000242114.5,MTFP1,22,,,,0,High,1
P54750,"Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A OS=Homo sapiens OX=9606 GN=PDE1A PE=1 SV=2",0,31.333,9,4,47,2,535,61.2,6.1,22638,,4,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00233, Pf08499",5136,ENSG00000115252.18,PDE1A,2,Purine metabolism; Taste transduction; Olfactory transduction; Renin secretion; Calcium signaling pathway; Morphine addiction,G Protein Signaling Pathways,G alpha (s) signalling events; Cam-PDE 1 activation; cGMP effects,24,High,1
Q96NY7,Chloride intracellular channel protein 6 OS=Homo sapiens OX=9606 GN=CLIC6 PE=2 SV=3,0,31.322,8,6,57,4,704,73,4.37,28809,,6,,metabolic process;regulation of biological process;transport,cytoplasm;membrane;nucleus,catalytic activity;protein binding;transporter activity,"Pf00043, Pf13409, Pf13410, Pf13417, Pf14497",54102,ENSG00000159212.12,CLIC6,21,,,,0,High,1
Q9BZG1,Ras-related protein Rab-34 OS=Homo sapiens OX=9606 GN=RAB34 PE=1 SV=1,0,31.301,34,8,73,7,259,29,7.88,37494,,8,,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;Golgi;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf01926, Pf04670, Pf08477",83871,ENSG00000109113.18,RAB34,17,,,RAB geranylgeranylation,3,High,1
Q9HC35,Echinoderm microtubule-associated protein-like 4 OS=Homo sapiens OX=9606 GN=EML4 PE=1 SV=3,0,31.269,11,8,17,8,981,108.8,6.4,5764,,8,,,cytoplasm;cytoskeleton;membrane,protein binding,"Pf00400, Pf03451",27436,ENSG00000143924.18,EML4,2,Non-small cell lung cancer,,,1,High,1
Q9Y3E7,Charged multivesicular body protein 3 OS=Homo sapiens OX=9606 GN=CHMP3 PE=1 SV=3,0,31.208,36,6,51,6,222,25.1,5.12,16174,2.08,6,2,cell communication;cell death;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane,protein binding,Pf03357,51652; 100526767,ENSG00000115561.15,CHMP3; RNF103-CHMP3,2,Endocytosis,,Budding and maturation of HIV virion; Macroautophagy; Endosomal Sorting Complex Required For Transport (ESCRT),12,High,1
Q9NTZ6,RNA-binding protein 12 OS=Homo sapiens OX=9606 GN=RBM12 PE=1 SV=1,0,31.165,11,9,32,9,932,97.3,8.63,10985,,9,,,nucleus,protein binding;RNA binding,"Pf00076, Pf14259",10137,ENSG00000244462.7,RBM12,20,,,,0,High,1
Q96EP0,E3 ubiquitin-protein ligase RNF31 OS=Homo sapiens OX=9606 GN=RNF31 PE=1 SV=1,0,31.163,13,8,23,8,1072,119.6,6.57,8229,,8,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,catalytic activity;metal ion binding;protein binding,"Pf01485, Pf09409",55072,ENSG00000092098.16,RNF31,14,NOD-like receptor signaling pathway,Regulation of toll-like receptor signaling pathway,Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway,7,High,1
P04278,Sex hormone-binding globulin OS=Homo sapiens OX=9606 GN=SHBG PE=1 SV=2,0,31.162,27,6,17,6,402,43.8,6.71,7553,0,6,1,,extracellular,protein binding,"Pf00054, Pf02210, Pf06439",6462,ENSG00000129214.14,SHBG,17,,,,0,High,1
Q8IWT6,Volume-regulated anion channel subunit LRRC8A OS=Homo sapiens OX=9606 GN=LRRC8A PE=1 SV=1,0,31.16,8,7,23,7,810,94.1,7.94,9981,,7,,cell differentiation;cellular homeostasis;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;membrane,protein binding;transporter activity,"Pf12534, Pf12799, Pf13855",56262,ENSG00000136802.11,LRRC8A,9,,,Miscellaneous transport and binding events,2,High,1
P11387,DNA topoisomerase 1 OS=Homo sapiens OX=9606 GN=TOP1 PE=1 SV=2,0,31.153,10,7,35,7,765,90.7,9.31,14450,,7,,cell death;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding,"Pf01028, Pf02919, Pf14370",7150,ENSG00000198900.5,TOP1,20,,,SUMOylation of DNA replication proteins,5,High,1
Q96EE3-1,Isoform B of Nucleoporin SEH1 OS=Homo sapiens OX=9606 GN=SEH1L,0,31.145,21,6,15,6,421,46.5,7.9,6185,2.26,5,2,cell communication;cell division;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,chromosome;cytosol;membrane,protein binding,Pf00400,81929,ENSG00000085415.15,SEH1L,18,,,Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins,16,High,1
P16298,Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform OS=Homo sapiens OX=9606 GN=PPP3CB PE=1 SV=2,0,31.144,11,5,23,1,524,59,5.91,10984,,5,,cell differentiation;cell growth;cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;membrane,catalytic activity;metal ion binding;protein binding,Pf00149,5532,ENSG00000107758.15,PPP3CB,10,Natural killer cell mediated cytotoxicity; Renin secretion; Osteoclast differentiation; Oocyte meiosis; Tuberculosis; MAPK signaling pathway; Amphetamine addiction; Axon guidance; Th1 and Th2 cell differentiation; Wnt signaling pathway; B cell receptor signaling pathway; Glucagon signaling pathway; cGMP-PKG signaling pathway; Calcium signaling pathway; Long-term potentiation; Glutamatergic synapse; Amyotrophic lateral sclerosis (ALS); Oxytocin signaling pathway; T cell receptor signaling pathway; Alzheimer's disease; VEGF signaling pathway; Dopaminergic synapse; HTLV-I infection,Physiological and Pathological Hypertrophy  of the Heart; Energy Metabolism; MicroRNAs in cardiomyocyte hypertrophy; Alzheimers Disease; Amyotrophic lateral sclerosis (ALS); Initiation of transcription and translation elongation at the HIV-1 LTR; MAPK Signaling Pathway,Signaling by GPCR; FCERI mediated Ca+2 mobilization; DARPP-32 events; ROBO receptors bind AKAP5; Ca2+ pathway; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT,52,High,1
Q9H4G4,Golgi-associated plant pathogenesis-related protein 1 OS=Homo sapiens OX=9606 GN=GLIPR2 PE=1 SV=3,0,31.089,49,5,25,5,154,17.2,9.41,11152,,5,,regulation of biological process,extracellular;Golgi;membrane,protein binding,Pf00188,152007,ENSG00000122694.15,GLIPR2,9,,,,0,High,1
P10619,Lysosomal protective protein OS=Homo sapiens OX=9606 GN=CTSA PE=1 SV=2,0,31.016,13,5,28,5,480,54.4,6.61,16435,,5,,metabolic process;regulation of biological process;transport,endoplasmic reticulum;extracellular;membrane;organelle lumen;vacuole,catalytic activity;enzyme regulator activity,Pf00450,5476,ENSG00000064601.16,CTSA,20,Lysosome; Renin-angiotensin system,,Sialic acid metabolism; Neutrophil degranulation; Glycosphingolipid metabolism; MHC class II antigen presentation,17,High,1
Q05932,"Folylpolyglutamate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=FPGS PE=1 SV=3",0,30.98,11,4,19,4,587,64.6,7.94,8915,,4,,cell proliferation;metabolic process,cytoplasm;cytosol;membrane;mitochondrion;organelle lumen,catalytic activity;metal ion binding;nucleotide binding,Pf02875,2356,ENSG00000136877.14,FPGS,9,Metabolic pathways; Folate biosynthesis; Antifolate resistance,Fluoropyrimidine Activity,Metabolism of folate and pterines,8,High,1
Q14061,Cytochrome c oxidase copper chaperone OS=Homo sapiens OX=9606 GN=COX17 PE=1 SV=2,0,30.916,25,3,48,3,63,6.9,7.24,29130,,3,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;mitochondrion,metal ion binding;protein binding,Pf05051,10063,ENSG00000138495.6,COX17,3,Metabolic pathways; Oxidative phosphorylation,Electron Transport Chain; Copper homeostasis,Mitochondrial protein import; Metabolism of proteins,6,High,1
Q969G3,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 OS=Homo sapiens OX=9606 GN=SMARCE1 PE=1 SV=2,0,30.88,15,5,23,5,411,46.6,4.88,8508,0,5,1,cell differentiation;cell organization and biogenesis;regulation of biological process,chromosome;nucleus,catalytic activity;DNA binding;protein binding;RNA binding,Pf00505,6605,ENSG00000073584.18,SMARCE1,17,,Androgen receptor signaling pathway; Pathways Affected in Adenoid Cystic Carcinoma,RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines,10,High,1
Q9Y3D2,"Methionine-R-sulfoxide reductase B2, mitochondrial OS=Homo sapiens OX=9606 GN=MSRB2 PE=1 SV=2",0,30.848,19,4,105,4,182,19.5,8.63,52974,0,4,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytosol;mitochondrion,catalytic activity;metal ion binding;protein binding,Pf01641,22921,ENSG00000148450.12,MSRB2,10,,Sulindac Metabolic Pathway,Protein repair,3,High,1
Q9UQ13,Leucine-rich repeat protein SHOC-2 OS=Homo sapiens OX=9606 GN=SHOC2 PE=1 SV=2,0,30.84,11,6,23,6,582,64.8,8.46,9440,,6,,regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,enzyme regulator activity;protein binding,"Pf12799, Pf13855",8036,ENSG00000108061.11,SHOC2,10,Ras signaling pathway,,,1,High,1
P21926,CD9 antigen OS=Homo sapiens OX=9606 GN=CD9 PE=1 SV=4,0,30.838,10,4,58,4,228,25.4,7.15,29658,,4,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;membrane,protein binding,Pf00335,928,ENSG00000010278.12,CD9,12,Hematopoietic cell lineage,,Platelet degranulation ; Sperm:Oocyte Membrane Binding; Uptake and function of diphtheria toxin,12,High,1
P22792,Carboxypeptidase N subunit 2 OS=Homo sapiens OX=9606 GN=CPN2 PE=1 SV=3,0,30.8,16,7,34,7,545,60.5,5.99,11560,,7,,metabolic process;regulation of biological process,extracellular,catalytic activity;enzyme regulator activity;protein binding,"Pf12799, Pf13855",1370,ENSG00000178772.6,CPN2,3,,,Regulation of Complement cascade,4,High,1
P39880,Homeobox protein cut-like 1 OS=Homo sapiens OX=9606 GN=CUX1 PE=1 SV=3,0,30.798,4,5,16,5,1505,164.1,5.9,6422,,5,,cell organization and biogenesis;cellular component movement;development;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;Golgi;membrane;nucleus,catalytic activity;DNA binding;motor activity;protein binding,"Pf00046, Pf00261, Pf00769, Pf01576, Pf02376, Pf02463, Pf03938, Pf04111, Pf04156, Pf05557, Pf05622, Pf05701, Pf05911, Pf06160, Pf07902, Pf07926, Pf09731, Pf09787, Pf10174, Pf10186, Pf11559, Pf12072, Pf12128, Pf12729, Pf13166, Pf13514, Pf13851, Pf14915, Pf15066, Pf15397, Pf15619",1523,ENSG00000257923.9,CUX1,7,,,Signaling by cytosolic FGFR1 fusion mutants,6,High,1
Q15208,Serine/threonine-protein kinase 38 OS=Homo sapiens OX=9606 GN=STK38 PE=1 SV=1,0,30.78,15,5,23,5,465,54.2,7.15,9679,,5,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf00433, Pf01636, Pf07714, Pf14531",11329,ENSG00000112079.8,STK38,6,,Interactome of polycomb repressive complex 2 (PRC2),,1,High,1
Q9Y365,START domain-containing protein 10 OS=Homo sapiens OX=9606 GN=STARD10 PE=1 SV=2,0,30.76,28,7,26,7,291,33,7.12,9946,,7,,metabolic process;regulation of biological process;transport,cytoplasm;cytosol;membrane,protein binding,Pf01852,10809,ENSG00000214530.8,STARD10,11,,,Synthesis of PC,5,High,1
Q86YQ8,Copine-8 OS=Homo sapiens OX=9606 GN=CPNE8 PE=1 SV=2,0,30.757,14,7,71,3,564,63.1,5.96,39571,,7,,,,protein binding,"Pf00168, Pf07002, Pf10138",144402,ENSG00000139117.13,CPNE8,12,,,,0,High,1
Q9BV19,Uncharacterized protein C1orf50 OS=Homo sapiens OX=9606 GN=C1orf50 PE=1 SV=2,0,30.711,33,3,21,3,199,21.9,5.88,10776,,3,,,,protein binding,Pf10504,79078,ENSG00000164008.14,C1orf50,1,,,,0,High,1
P04216,Thy-1 membrane glycoprotein OS=Homo sapiens OX=9606 GN=THY1 PE=1 SV=2,0,30.707,16,2,79,2,161,17.9,8.73,37430,,2,,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cell surface;cytosol;endoplasmic reticulum;extracellular;membrane,enzyme regulator activity;protein binding,Pf00047,7070,ENSG00000154096.13,THY1,11,Leukocyte transendothelial migration,Cardiac Progenitor Differentiation,Post-translational modification: synthesis of GPI-anchored proteins,5,High,1
P62328,Thymosin beta-4 OS=Homo sapiens OX=9606 GN=TMSB4X PE=1 SV=2,0,30.672,52,2,110,2,44,5.1,5.06,44377,0,2,1,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen,catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding;structural molecule activity,Pf01290,7114,ENSG00000205542.10,TMSB4X,X,Regulation of actin cytoskeleton,TarBasePathway; Regulation of Actin Cytoskeleton,Platelet degranulation,7,High,1
Q9BXB4,Oxysterol-binding protein-related protein 11 OS=Homo sapiens OX=9606 GN=OSBPL11 PE=1 SV=2,0,30.668,11,7,28,6,747,83.6,7.06,11094,,7,,cell differentiation;regulation of biological process;transport,endosome;Golgi;membrane,,"Pf00169, Pf01237, Pf15409",114885,ENSG00000144909.7,OSBPL11,3,,,,0,High,1
Q9H3K6,BolA-like protein 2 OS=Homo sapiens OX=9606 GN=BOLA2 PE=1 SV=1,0,30.66,50,4,38,4,86,10.1,6.52,17549,,4,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,protein binding,Pf01722,654483; 552900; 107984053,,BOLA2B; BOLA2; LOC107984053,16,,,Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Interleukin-12 family signaling,5,High,1
Q9BTY2,Plasma alpha-L-fucosidase OS=Homo sapiens OX=9606 GN=FUCA2 PE=1 SV=2,0,30.644,15,7,32,7,467,54,6.25,12276,,7,,metabolic process;regulation of biological process;response to stimulus;transport,extracellular;organelle lumen,catalytic activity;protein binding,Pf01120,2519,ENSG00000001036.13,FUCA2,6,Other glycan degradation,,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Neutrophil degranulation,8,High,1
O60573,Eukaryotic translation initiation factor 4E type 2 OS=Homo sapiens OX=9606 GN=EIF4E2 PE=1 SV=1,0,30.637,29,5,23,5,245,28.3,8.88,8758,,5,,metabolic process;regulation of biological process,cytoplasm;cytosol,protein binding;RNA binding,Pf01652,9470,ENSG00000135930.13,EIF4E2,2,mTOR signaling pathway; Insulin signaling pathway; Longevity regulating pathway; EGFR tyrosine kinase inhibitor resistance; RNA transport; HIF-1 signaling pathway; PI3K-Akt signaling pathway,Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,ISG15 antiviral mechanism,13,High,1
Q9H9T3,Elongator complex protein 3 OS=Homo sapiens OX=9606 GN=ELP3 PE=1 SV=2,0,30.614,13,6,34,6,547,62.2,8.88,13656,1.83,6,1,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process,cytoplasm;nucleus,catalytic activity;enzyme regulator activity;metal ion binding;protein binding,Pf04055,55140,ENSG00000134014.16,ELP3,8,,,HATs acetylate histones,3,High,1
Q15050,Ribosome biogenesis regulatory protein homolog OS=Homo sapiens OX=9606 GN=RRS1 PE=1 SV=2,0,30.606,22,7,32,7,365,41.2,10.7,12481,,7,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;transport,chromosome;endoplasmic reticulum;nucleus,protein binding;RNA binding,Pf04939,23212,ENSG00000179041.3,RRS1,8,,,,0,High,1
P16333,Cytoplasmic protein NCK1 OS=Homo sapiens OX=9606 GN=NCK1 PE=1 SV=1,0,30.605,19,7,24,6,377,42.8,6.47,8149,,7,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus;ribosome,enzyme regulator activity;protein binding;structural molecule activity,"Pf00017, Pf00018, Pf07653, Pf08239, Pf14604",4690,ENSG00000158092.6,NCK1,3,T cell receptor signaling pathway; Pathogenic Escherichia coli infection; Axon guidance; ErbB signaling pathway,Pathogenic Escherichia coli infection; B Cell Receptor Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Primary Focal Segmental Glomerulosclerosis FSGS; Rac1/Pak1/p38/MMP-2 pathway; Association Between Physico-Chemical Features and Toxicity Associated Pathways; T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 Signaling Pathway; EGF/EGFR Signaling Pathway; ErbB Signaling Pathway; T-Cell antigen Receptor (TCR)  Signaling Pathway,DCC mediated attractive signaling; VEGFA-VEGFR2 Pathway; Downstream signal transduction; Nephrin family interactions; Activation of RAC1; Generation of second messenger molecules; RHO GTPases Activate WASPs and WAVEs; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers,41,High,1
Q9Y237,Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 OS=Homo sapiens OX=9606 GN=PIN4 PE=1 SV=1,0,30.605,48,5,32,5,131,13.8,9.77,11951,,5,,metabolic process,cytoplasm;cytoskeleton;mitochondrion;nucleus;organelle lumen,catalytic activity;DNA binding;protein binding;RNA binding,"Pf00639, Pf13145, Pf13616",5303,,PIN4,X,,,,0,High,1
P29466,Caspase-1 OS=Homo sapiens OX=9606 GN=CASP1 PE=1 SV=1,0,30.593,21,6,14,6,404,45.1,5.91,8240,,6,,cell death;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;mitochondrion,catalytic activity;enzyme regulator activity;protein binding,"Pf00619, Pf00656",834,ENSG00000137752.23,CASP1,11,Cytosolic DNA-sensing pathway; Influenza A; NOD-like receptor signaling pathway; Salmonella infection; Pertussis; Legionellosis; Amyotrophic lateral sclerosis (ALS),Nucleotide-binding Oligomerization Domain (NOD) pathway; Apoptosis Modulation and Signaling; Parkin-Ubiquitin Proteasomal System pathway; Amyotrophic lateral sclerosis (ALS); Apoptosis; MAPK Signaling Pathway,The IPAF inflammasome; The AIM2 inflammasome; NOD1/2 Signaling Pathway; Interleukin-1 processing; TP53 Regulates Transcription of Caspase Activators and Caspases; The NLRP3 inflammasome,31,High,1
O00408,"cGMP-dependent 3',5'-cyclic phosphodiesterase OS=Homo sapiens OX=9606 GN=PDE2A PE=1 SV=1",0,30.537,10,7,101,6,941,105.6,5.41,42013,,7,,cell differentiation;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;Golgi;membrane;mitochondrion;nucleus;organelle lumen,catalytic activity;metal ion binding;nucleotide binding;protein binding;transporter activity,"Pf00233, Pf01590, Pf13185, Pf13492",5138,ENSG00000186642.15,PDE2A,11,Olfactory transduction; cGMP-PKG signaling pathway; Morphine addiction; Purine metabolism; Aldosterone synthesis and secretion,,G alpha (s) signalling events; cGMP effects,13,High,1
O00499,Myc box-dependent-interacting protein 1 OS=Homo sapiens OX=9606 GN=BIN1 PE=1 SV=1,0,30.531,14,5,15,5,593,64.7,5.06,6880,,5,,cell differentiation;cell organization and biogenesis;cell proliferation;development;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,protein binding,"Pf00018, Pf03114, Pf07653, Pf14604",274,ENSG00000136717.14,BIN1,2,Endocytosis; Fc gamma R-mediated phagocytosis,VEGFA-VEGFR2 Signaling Pathway,Clathrin-mediated endocytosis,6,High,1
Q7LBC6,Lysine-specific demethylase 3B OS=Homo sapiens OX=9606 GN=KDM3B PE=1 SV=2,0,30.492,7,6,15,6,1761,191.5,7.18,5017,,6,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;nucleus,antioxidant activity;catalytic activity;DNA binding;metal ion binding,Pf02373,51780,ENSG00000120733.13,KDM3B,5,,,HDMs demethylate histones,3,High,1
P42773,Cyclin-dependent kinase 4 inhibitor C OS=Homo sapiens OX=9606 GN=CDKN2C PE=1 SV=1,0,30.466,38,5,31,5,168,18.1,6.52,11488,,5,,cell differentiation;metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;enzyme regulator activity;protein binding,"Pf00023, Pf12796, Pf13606, Pf13637, Pf13857",1031,ENSG00000123080.10,CDKN2C,1,Endocrine resistance; HTLV-I infection; Cell cycle; Transcriptional misregulation in cancer,Signaling Pathways in Glioblastoma; G1 to S cell cycle control,Cyclin D associated events in G1; Oncogene Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Oxidative Stress Induced Senescence,17,High,1
P27487,Dipeptidyl peptidase 4 OS=Homo sapiens OX=9606 GN=DPP4 PE=1 SV=2,0,30.458,7,5,27,5,766,88.2,6.04,12817,,5,,cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus,cell surface;extracellular;membrane,catalytic activity;protein binding;receptor activity,"Pf00326, Pf00930, Pf01738, Pf12695, Pf12697",1803,ENSG00000197635.9,DPP4,2,Protein digestion and absorption,,"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)",6,High,1
P22612,cAMP-dependent protein kinase catalytic subunit gamma OS=Homo sapiens OX=9606 GN=PRKACG PE=1 SV=3,0,30.453,9,2,80,1,351,40.4,8.59,39219,,2,,cell organization and biogenesis;coagulation;metabolic process;regulation of biological process;response to stimulus,cytosol,catalytic activity;nucleotide binding,"Pf00069, Pf01636, Pf07714, Pf14531",5568,ENSG00000165059.7,PRKACG,9,Prion diseases; Morphine addiction; Retrograde endocannabinoid signaling; Regulation of lipolysis in adipocytes; Dopaminergic synapse; Oxytocin signaling pathway; Wnt signaling pathway; GnRH signaling pathway; Amphetamine addiction; Taste transduction; Salivary secretion; Insulin signaling pathway; Thyroid hormone signaling pathway; Vasopressin-regulated water reabsorption; Longevity regulating pathway; Longevity regulating pathway - multiple species; Circadian entrainment; Proteoglycans in cancer; cAMP signaling pathway; Progesterone-mediated oocyte maturation; Thyroid hormone synthesis; Ras signaling pathway; Dilated cardiomyopathy; Gap junction; Gastric acid secretion; Vascular smooth muscle contraction; Pathways in cancer; Oocyte meiosis; Cholinergic synapse; Renin secretion; Glucagon signaling pathway; Inflammatory mediator regulation of TRP channels; Amoebiasis; Endocrine and other factor-regulated calcium reabsorption; Aldosterone synthesis and secretion; Estrogen signaling pathway; Bile secretion; Adrenergic signaling in cardiomyocytes; GABAergic synapse; Serotonergic synapse; Olfactory transduction; Parkinson's disease; Chemokine signaling pathway; Ovarian steroidogenesis; Insulin secretion; Hedgehog signaling pathway; Platelet activation; Viral carcinogenesis; MAPK signaling pathway; Melanogenesis; Endocrine resistance; Glutamatergic synapse; Long-term potentiation; Cocaine addiction; Calcium signaling pathway; Epstein-Barr virus infection; HTLV-I infection; Vibrio cholerae infection,AMP-activated Protein Kinase (AMPK) Signaling; miRs in Muscle Cell Differentiation; Dopamine metabolism; Common Pathways Underlying Drug Addiction; G Protein Signaling Pathways; Chemokine signaling pathway,Triglyceride catabolism; Glycolysis; ROBO receptors bind AKAP5; HDL assembly; GLI3 is processed to GLI3R by the proteasome; Vasopressin regulates renal water homeostasis via Aquaporins; Factors involved in megakaryocyte development and platelet production; Signaling by GPCR; Rap1 signalling; Degradation of GLI1 by the proteasome; PKA activation in glucagon signalling; Degradation of GLI2 by the proteasome; CREB phosphorylation through the activation of Adenylate Cyclase; DARPP-32 events; VEGFA-VEGFR2 Pathway; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; CD209 (DC-SIGN) signaling; PKA-mediated phosphorylation of key metabolic factors; PKA activation; RET signaling; MAPK6/MAPK4 signaling,125,High,1
P49750-1,Isoform 1 of YLP motif-containing protein 1 OS=Homo sapiens OX=9606 GN=YLPM1,0,30.44,4,5,23,5,1951,219.8,6.57,8691,,5,,metabolic process;regulation of biological process,cytosol;nucleus,protein binding;RNA binding,"Pf13207, Pf13671",56252,,YLPM1,14,,,,0,High,1
A0A0B4J2D9,Immunoglobulin kappa variable 1D-13 OS=Homo sapiens OX=9606 GN=IGKV1D-13 PE=3 SV=1,0,30.418,29,2,29,2,117,12.6,7.84,17707,,2,,response to stimulus,extracellular;membrane,,"Pf00047, Pf07679, Pf07686, Pf13927",28902; 28939,ENSG00000276566.1,IGKV1D-13; IGKV1-13,2,,,,0,High,1
O94952-1,Isoform 2 of F-box only protein 21 OS=Homo sapiens OX=9606 GN=FBXO21,0,30.415,12,6,37,6,621,71.4,6.01,13856,,6,,metabolic process,cytosol,catalytic activity;DNA binding;protein binding,"Pf00646, Pf08755, Pf12937, Pf13369",23014,ENSG00000135108.14,FBXO21,12,,,,0,High,1
Q5EBM0,"UMP-CMP kinase 2, mitochondrial OS=Homo sapiens OX=9606 GN=CMPK2 PE=1 SV=3",0,30.405,14,5,24,5,449,49.4,7.01,10807,0,5,1,metabolic process;response to stimulus,mitochondrion,catalytic activity;nucleotide binding,Pf02223,129607,ENSG00000134326.11,CMPK2,2,Metabolic pathways; Pyrimidine metabolism,,,2,High,1
P27482,Calmodulin-like protein 3 OS=Homo sapiens OX=9606 GN=CALML3 PE=1 SV=2,0,30.391,23,3,392,1,149,16.9,4.42,191526,0,3,2,,,metal ion binding;protein binding,"Pf00036, Pf08726, Pf13202, Pf13405, Pf13499, Pf13833",810,ENSG00000178363.4,CALML3,10,Phototransduction; Glucagon signaling pathway; Glioma; cAMP signaling pathway; Rap1 signaling pathway; Salivary secretion; Amphetamine addiction; Alzheimer's disease; Adrenergic signaling in cardiomyocytes; Calcium signaling pathway; Circadian entrainment; Ras signaling pathway; Renin secretion; Oocyte meiosis; Vascular smooth muscle contraction; Pertussis; Oxytocin signaling pathway; Inflammatory mediator regulation of TRP channels; Dopaminergic synapse; Tuberculosis; Neurotrophin signaling pathway; Gastric acid secretion; Phosphatidylinositol signaling system; Estrogen signaling pathway; cGMP-PKG signaling pathway; Aldosterone synthesis and secretion; Long-term potentiation; GnRH signaling pathway; Insulin signaling pathway; Melanogenesis; Olfactory transduction; Alcoholism,Alzheimers Disease,,33,High,1
Q9UNP9,Peptidyl-prolyl cis-trans isomerase E OS=Homo sapiens OX=9606 GN=PPIE PE=1 SV=1,0,30.357,20,4,115,3,301,33.4,5.6,55112,,4,,metabolic process;regulation of biological process;response to stimulus;transport,cytosol;extracellular;nucleus;organelle lumen;spliceosomal complex,catalytic activity;protein binding;RNA binding,"Pf00076, Pf00160, Pf13893, Pf14259",10450,ENSG00000084072.16,PPIE,1,Spliceosome,,Dual incision in TC-NER; Formation of TC-NER Pre-Incision Complex; Neutrophil degranulation; mRNA Splicing - Major Pathway; Gap-filling DNA repair synthesis and ligation in TC-NER,14,High,1
P62310,U6 snRNA-associated Sm-like protein LSm3 OS=Homo sapiens OX=9606 GN=LSM3 PE=1 SV=2,0,30.353,41,4,34,4,102,11.8,4.7,18493,,4,,cell organization and biogenesis;metabolic process,cytosol;nucleus;spliceosomal complex,protein binding;RNA binding,Pf01423,27258,ENSG00000170860.3,LSM3,3,Spliceosome; RNA degradation,,mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease,8,High,1
Q6DN03,Putative histone H2B type 2-C OS=Homo sapiens OX=9606 GN=HIST2H2BC PE=5 SV=3,0,30.329,13,3,151,3,193,21.5,10.7,87736,0,3,1,cell organization and biogenesis,chromosome;nucleus,DNA binding;protein binding,Pf00125,337873,,HIST2H2BC,1,,,,0,High,1
O43716,"Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial OS=Homo sapiens OX=9606 GN=GATC PE=1 SV=1",0,30.323,47,5,29,5,136,15.1,5.05,14323,,5,,cell organization and biogenesis;metabolic process;regulation of biological process,mitochondrion,catalytic activity;nucleotide binding;protein binding,Pf02686,283459,ENSG00000257218.5,GATC,12,Metabolic pathways; Aminoacyl-tRNA biosynthesis,,,2,High,1
Q8IYB7,DIS3-like exonuclease 2 OS=Homo sapiens OX=9606 GN=DIS3L2 PE=1 SV=4,0,30.299,12,8,20,8,885,99.2,6.1,7333,,8,,cell division;metabolic process;regulation of biological process,cytoplasm,catalytic activity;metal ion binding;protein binding;RNA binding,Pf00773,129563,ENSG00000144535.19,DIS3L2,2,,,,0,High,1
P03891,NADH-ubiquinone oxidoreductase chain 2 OS=Homo sapiens OX=9606 GN=MT-ND2 PE=1 SV=2,0,30.266,10,3,104,3,347,38.9,9.83,49225,3.42,3,1,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion,catalytic activity;protein binding,Pf00361,4536,ENSG00000198763.3,ND2,MT,Parkinson's disease; Metabolic pathways; Oxidative phosphorylation,Electron Transport Chain; Oxidative phosphorylation,Complex I biogenesis,10,High,1
P08579,U2 small nuclear ribonucleoprotein B'' OS=Homo sapiens OX=9606 GN=SNRPB2 PE=1 SV=1,0,30.23,28,5,47,3,225,25.5,9.72,23361,,5,,metabolic process,nucleus;spliceosomal complex,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",6629,ENSG00000125870.10,SNRPB2,20,Spliceosome,mRNA Processing,mRNA Splicing - Major Pathway,6,High,1
P17152,"Transmembrane protein 11, mitochondrial OS=Homo sapiens OX=9606 GN=TMEM11 PE=1 SV=1",0,30.214,17,3,48,3,192,21.5,7.36,23684,,3,,cell organization and biogenesis,membrane;mitochondrion,protein binding,Pf14972,8834,ENSG00000178307.9,TMEM11,17,,,Cristae formation,3,High,1
Q9H2D1,Mitochondrial folate transporter/carrier OS=Homo sapiens OX=9606 GN=SLC25A32 PE=1 SV=2,0,30.209,26,6,17,6,315,35.4,9.45,7305,,6,,metabolic process;transport,membrane;mitochondrion,transporter activity,Pf00153,81034,ENSG00000164933.11,SLC25A32,8,,,Metabolism of folate and pterines,4,High,1
Q14554,Protein disulfide-isomerase A5 OS=Homo sapiens OX=9606 GN=PDIA5 PE=1 SV=1,0,30.159,14,6,21,6,519,59.6,7.91,8799,,6,,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;membrane;organelle lumen,catalytic activity;protein binding,"Pf00085, Pf11009, Pf13098, Pf13899, Pf13905",10954,ENSG00000065485.19,PDIA5,3,,,XBP1(S) activates chaperone genes,4,High,1
Q9H773,dCTP pyrophosphatase 1 OS=Homo sapiens OX=9606 GN=DCTPP1 PE=1 SV=1,0,30.142,32,6,32,6,170,18.7,5.03,12877,0,6,2,cell communication;cell organization and biogenesis;metabolic process;response to stimulus,cytoplasm;cytosol;mitochondrion;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,,79077,ENSG00000179958.8,DCTPP1,16,Metabolic pathways; Pyrimidine metabolism,,Interconversion of nucleotide di- and triphosphates,5,High,1
L0R6Q1,SLC35A4 upstream open reading frame protein OS=Homo sapiens OX=9606 GN=SLC35A4 PE=3 SV=1,0,30.133,58,6,68,6,103,11.1,8.1,32295,0,6,1,regulation of biological process;response to stimulus;transport,Golgi;membrane,transporter activity,"Pf06553, Pf15054",113829,ENSG00000176087.14,SLC35A4,5,,,,0,High,1
Q92797,Symplekin OS=Homo sapiens OX=9606 GN=SYMPK PE=1 SV=2,0,30.13,8,7,15,7,1274,141.1,6.13,5084,0,7,1,metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,protein binding,"Pf11935, Pf12295",8189,ENSG00000125755.18,SYMPK,19,Tight junction; mRNA surveillance pathway,,mRNA 3'-end processing; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA Splicing - Major Pathway; Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs,16,High,1
Q5TDH0,Protein DDI1 homolog 2 OS=Homo sapiens OX=9606 GN=DDI2 PE=1 SV=1,0,30.116,22,5,19,5,399,44.5,5.05,8749,,5,,metabolic process,cytosol,catalytic activity;protein binding,"Pf00077, Pf00240, Pf08284, Pf09668, Pf13650, Pf13975",84301,ENSG00000197312.11,DDI2,1,,,,0,High,1
Q5HYI7,Metaxin-3 OS=Homo sapiens OX=9606 GN=MTX3 PE=1 SV=2,0,30.106,23,6,13,6,312,35.1,7.8,4861,0,6,1,transport,membrane;mitochondrion,,"Pf10568, Pf11801, Pf13410, Pf14497",345778,ENSG00000177034.14,MTX3,5,,,,0,High,1
P51784,Ubiquitin carboxyl-terminal hydrolase 11 OS=Homo sapiens OX=9606 GN=USP11 PE=1 SV=3,0,30.073,7,6,36,3,963,109.7,5.45,13049,,6,,metabolic process,chromosome;cytoplasm;cytosol;nucleus,catalytic activity;protein binding,"Pf00443, Pf06337, Pf13423, Pf14533, Pf14836",8237,ENSG00000102226.9,USP11,X,,,Association of TriC/CCT with target proteins during biosynthesis; Ub-specific processing proteases,7,High,1
Q9UKK3,Protein mono-ADP-ribosyltransferase PARP4 OS=Homo sapiens OX=9606 GN=PARP4 PE=1 SV=3,0,30.024,5,7,23,7,1724,192.5,5.66,9338,,7,,cell death;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,catalytic activity;DNA binding;protein binding,"Pf00092, Pf00533, Pf00644, Pf02877, Pf08487, Pf13519, Pf13757, Pf13768",143,ENSG00000102699.5,PARP4,13,Base excision repair; Apoptosis,NAD+ biosynthetic pathways,Nicotinamide salvaging,8,High,1
Q96T51,RUN and FYVE domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RUFY1 PE=1 SV=2,0,29.988,14,8,17,7,708,79.8,5.74,7191,,8,,metabolic process;regulation of biological process;transport,cytoplasm;cytosol;endosome;membrane,metal ion binding;protein binding;transporter activity,"Pf01363, Pf02759, Pf14634",80230,ENSG00000176783.14; ENSG00000284260.1,RUFY1,5; CHR_HG30_PATCH,Endocytosis,,Synthesis of PIPs at the plasma membrane,6,High,1
Q9NUM4,Transmembrane protein 106B OS=Homo sapiens OX=9606 GN=TMEM106B PE=1 SV=2,0,29.957,29,6,17,6,274,31.1,6.99,7065,,6,,cell organization and biogenesis;regulation of biological process;transport,endosome;membrane;vacuole,protein binding,Pf07092,54664,ENSG00000106460.18,TMEM106B,7,,,,0,High,1
P56545,C-terminal-binding protein 2 OS=Homo sapiens OX=9606 GN=CTBP2 PE=1 SV=1,0,29.951,15,6,68,4,445,48.9,6.95,32496,,6,,cell differentiation;metabolic process;regulation of biological process,cytosol;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00389, Pf02826",1488,ENSG00000175029.16,CTBP2,10,Pathways in cancer; Wnt signaling pathway; Chronic myeloid leukemia; Notch signaling pathway,Neural Crest Differentiation; Notch Signaling Pathway; Mesodermal Commitment Pathway; Wnt Signaling Pathway and Pluripotency,Repression of WNT target genes; TCF7L2 mutants don't bind CTBP,16,High,1
P61081,NEDD8-conjugating enzyme Ubc12 OS=Homo sapiens OX=9606 GN=UBE2M PE=1 SV=1,0,29.917,26,6,95,6,183,20.9,7.69,41836,0,6,1,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,catalytic activity;nucleotide binding;protein binding,Pf00179,9040,ENSG00000130725.7,UBE2M,19,Ubiquitin mediated proteolysis,,TGF-beta receptor signaling activates SMADs; NIK-->noncanonical NF-kB signaling; Dectin-1 mediated noncanonical NF-kB signaling; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation,19,High,1
P01624,Immunoglobulin kappa variable 3-15 OS=Homo sapiens OX=9606 GN=IGKV3-15 PE=1 SV=2,0,29.904,37,3,71,3,115,12.5,5.19,35413,,3,,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity,"Pf00047, Pf07679, Pf07686",28913,ENSG00000282447.1; ENSG00000244437.1,IGKV3-15,2; CHR_HG2290_PATCH,,,FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis,26,High,1
Q96MW5,Conserved oligomeric Golgi complex subunit 8 OS=Homo sapiens OX=9606 GN=COG8 PE=1 SV=2,0,29.892,12,5,21,5,612,68.4,5.2,8546,,5,,transport,Golgi;membrane,protein binding,Pf04124,84342,ENSG00000272617.2,COG8,16,,,COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network,11,High,1
Q53TN4,Cytochrome b reductase 1 OS=Homo sapiens OX=9606 GN=CYBRD1 PE=1 SV=1,0,29.878,19,5,27,5,286,31.6,8.76,13496,,5,,cellular homeostasis;metabolic process;response to stimulus;transport,membrane,catalytic activity;metal ion binding;protein binding,Pf03188,79901,ENSG00000071967.11,CYBRD1,2,Mineral absorption,,Iron uptake and transport,3,High,1
Q9H173,Nucleotide exchange factor SIL1 OS=Homo sapiens OX=9606 GN=SIL1 PE=1 SV=1,0,29.868,19,6,32,6,461,52.1,5.36,13337,,6,,metabolic process;transport,endoplasmic reticulum;organelle lumen,protein binding,,64374,ENSG00000120725.12,SIL1,5,Protein processing in endoplasmic reticulum,,,1,High,1
Q04206,Transcription factor p65 OS=Homo sapiens OX=9606 GN=RELA PE=1 SV=2,0,29.848,12,5,33,5,551,60.2,5.68,15979,,5,,defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,DNA binding;protein binding,Pf00554,5970,ENSG00000173039.18,RELA,11,Chagas disease (American trypanosomiasis); B cell receptor signaling pathway; Non-alcoholic fatty liver disease (NAFLD); Adipocytokine signaling pathway; Prolactin signaling pathway; Toxoplasmosis; Chemokine signaling pathway; Osteoclast differentiation; AGE-RAGE signaling pathway in diabetic complications; Hepatitis C; Inflammatory bowel disease (IBD); Acute myeloid leukemia; Sphingolipid signaling pathway; PI3K-Akt signaling pathway; Epstein-Barr virus infection; Salmonella infection; Legionellosis; HIF-1 signaling pathway; Pertussis; RIG-I-like receptor signaling pathway; TNF signaling pathway; Prostate cancer; Toll-like receptor signaling pathway; Chronic myeloid leukemia; Apoptosis; cAMP signaling pathway; Amoebiasis; MAPK signaling pathway; Measles; Shigellosis; Pancreatic cancer; HTLV-I infection; Epithelial cell signaling in Helicobacter pylori infection; Th1 and Th2 cell differentiation; Leishmaniasis; Cocaine addiction; Longevity regulating pathway; Hepatitis B; Tuberculosis; Ras signaling pathway; Viral carcinogenesis; Neurotrophin signaling pathway; Transcriptional misregulation in cancer; Insulin resistance; NOD-like receptor signaling pathway; NF-kappa B signaling pathway; Herpes simplex infection; Antifolate resistance; Cytosolic DNA-sensing pathway; Influenza A; T cell receptor signaling pathway; Pathways in cancer; Small cell lung cancer,Androgen receptor signaling pathway; Nucleotide-binding Oligomerization Domain (NOD) pathway; Osteopontin Signaling; Regulation of toll-like receptor signaling pathway; Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism; IL-1 signaling pathway; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; Leptin signaling pathway; TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway; Prolactin Signaling Pathway; IL17 signaling pathway; B Cell Receptor Signaling Pathway; AGE/RAGE pathway; Interleukin-11 Signaling Pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Apoptosis; Aryl Hydrocarbon Receptor; EBV LMP1 signaling; Structural Pathway of Interleukin 1 (IL-1); Selenium Metabolism and Selenoproteins; NLR Proteins; Rac1/Pak1/p38/MMP-2 pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Photodynamic therapy-induced NF-kB survival signaling; Toll-like Receptor Signaling; RIG-I-like Receptor Signaling; VEGFA-VEGFR2 Signaling Pathway; ApoE and miR-146 in inflammation and atherosclerosis; Chemokine signaling pathway; IL-4 Signaling Pathway; T-Cell antigen Receptor (TCR)  Signaling Pathway; Toll-like receptor signaling pathway,CLEC7A/inflammasome pathway; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); Regulated proteolysis of p75NTR; Downstream TCR signaling; Transcriptional regulation of white adipocyte differentiation; TRAF6 mediated NF-kB activation; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; RIP-mediated NFkB activation via ZBP1; Activated TLR4 signalling; Interleukin-1 processing; PKMTs methylate histone lysines; FCERI mediated NF-kB activation; CD209 (DC-SIGN) signaling; Activation of NF-kappaB in B cells; DEx/H-box helicases activate type I IFN and inflammatory cytokines production ; NF-kB is activated and signals survival; Dectin-1 mediated noncanonical NF-kB signaling; Signalling by NGF; IkBA variant leads to EDA-ID; Senescence-Associated Secretory Phenotype (SASP),153,High,1
P26927,Hepatocyte growth factor-like protein OS=Homo sapiens OX=9606 GN=MST1 PE=1 SV=2,0,29.847,7,4,36,4,711,80.3,7.68,15260,,4,,metabolic process;regulation of biological process;response to stimulus,extracellular,catalytic activity;protein binding,"Pf00024, Pf00051, Pf00089",4485,,MST1,3,,,Signaling by MST1,3,High,1
P50583,Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] OS=Homo sapiens OX=9606 GN=NUDT2 PE=1 SV=3,0,29.846,43,5,30,5,147,16.8,5.35,13131,,5,,cell death;metabolic process;response to stimulus,mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding,Pf00293,318,ENSG00000164978.17,NUDT2,9,Pyrimidine metabolism; Purine metabolism,,Detoxification of Reactive Oxygen Species,5,High,1
Q6P0Q8,Microtubule-associated serine/threonine-protein kinase 2 OS=Homo sapiens OX=9606 GN=MAST2 PE=1 SV=2,0,29.802,8,9,26,7,1798,196.3,8.16,8060,1.89,8,1,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf00595, Pf07714, Pf08926, Pf13180, Pf14531",23139,ENSG00000086015.20,MAST2,1,,,,0,High,1
O95749,Geranylgeranyl pyrophosphate synthase OS=Homo sapiens OX=9606 GN=GGPS1 PE=1 SV=1,0,29.797,18,4,40,4,300,34.8,6.14,14896,,4,,metabolic process;regulation of biological process,cytoplasm;cytosol,catalytic activity;metal ion binding;protein binding,Pf00348,9453,ENSG00000152904.11,GGPS1,1,Terpenoid backbone biosynthesis; Metabolic pathways,,Cholesterol biosynthesis; Activation of gene expression by SREBF (SREBP),8,High,1
Q13627,Dual specificity tyrosine-phosphorylation-regulated kinase 1A OS=Homo sapiens OX=9606 GN=DYRK1A PE=1 SV=2,0,29.785,8,5,18,4,763,85.5,8.75,8615,,5,,metabolic process;regulation of biological process,nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf01633, Pf07714",1859,ENSG00000157540.19,DYRK1A,21,,T-Cell Receptor and Co-stimulatory Signaling,G0 and Early G1,5,High,1
Q9NRG9,Aladin OS=Homo sapiens OX=9606 GN=AAAS PE=1 SV=1,0,29.781,13,6,41,6,546,59.5,7.5,16745,,6,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;membrane;nucleus,protein binding,Pf00400,8086,ENSG00000094914.12,AAAS,12,RNA transport,,Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins,64,High,1
Q6UWY5,Olfactomedin-like protein 1 OS=Homo sapiens OX=9606 GN=OLFML1 PE=1 SV=2,0,29.771,19,8,26,8,402,45.9,8.09,10802,,8,,,extracellular,,Pf02191,283298,ENSG00000183801.7,OLFML1,11,,,,0,High,1
O15228,Dihydroxyacetone phosphate acyltransferase OS=Homo sapiens OX=9606 GN=GNPAT PE=1 SV=1,0,29.768,14,6,19,6,680,77.1,6.57,7026,,6,,cell organization and biogenesis;metabolic process;response to stimulus,membrane;mitochondrion;organelle lumen,catalytic activity;protein binding,Pf01553,8443,ENSG00000116906.11,GNPAT,1,Peroxisome; Glycerophospholipid metabolism,Triacylglyceride Synthesis,Synthesis of PA; Plasmalogen biosynthesis,9,High,1
Q8TCT9-2,Isoform 2 of Minor histocompatibility antigen H13 OS=Homo sapiens OX=9606 GN=HM13,0,29.757,19,6,33,6,426,46.8,7.23,10487,19.67,4,2,cell organization and biogenesis;metabolic process,cell surface;endoplasmic reticulum;membrane,catalytic activity;protein binding,"Pf04258, Pf06550",81502,ENSG00000101294.16,HM13,20,,,,0,High,1
P39687,Acidic leucine-rich nuclear phosphoprotein 32 family member A OS=Homo sapiens OX=9606 GN=ANP32A PE=1 SV=1,0,29.725,20,4,33,3,249,28.6,4.09,13268,,4,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;nucleus,protein binding;RNA binding,"Pf12799, Pf13855, Pf14580",8125,ENSG00000140350.15,ANP32A,15,,,HuR (ELAVL1) binds and stabilizes mRNA,3,High,1
Q9NQ48,Leucine zipper transcription factor-like protein 1 OS=Homo sapiens OX=9606 GN=LZTFL1 PE=1 SV=1,0,29.683,20,5,35,5,299,34.6,5.36,13116,,5,,,cytoplasm;cytosol,protein binding,"Pf09731, Pf15294",54585,ENSG00000163818.16,LZTFL1,3,,,BBSome-mediated cargo-targeting to cilium,4,High,1
Q53SF7,Cordon-bleu protein-like 1 OS=Homo sapiens OX=9606 GN=COBLL1 PE=1 SV=3,0,29.639,8,7,27,7,1128,123.8,6.58,10746,,7,,,,,,,,,,,,,0,High,1
Q96S97,Myeloid-associated differentiation marker OS=Homo sapiens OX=9606 GN=MYADM PE=1 SV=2,0,29.631,16,3,20,3,322,35.3,8.15,11132,,3,,cell organization and biogenesis;regulation of biological process,cytoskeleton;membrane,,Pf01284,91663,ENSG00000179820.15,MYADM,19,,,,0,High,1
Q2M1Z3,Rho GTPase-activating protein 31 OS=Homo sapiens OX=9606 GN=ARHGAP31 PE=1 SV=2,0,29.625,6,6,15,6,1444,156.9,5.76,6337,,6,,regulation of biological process;response to stimulus,cytosol,enzyme regulator activity;protein binding,Pf00620,57514,ENSG00000031081.10,ARHGAP31,3,,,Rho GTPase cycle,3,High,1
Q9NPH0,Lysophosphatidic acid phosphatase type 6 OS=Homo sapiens OX=9606 GN=ACP6 PE=1 SV=3,0,29.564,15,6,22,6,428,48.9,6.47,8076,,6,,cell differentiation;metabolic process,cytoplasm;mitochondrion;organelle lumen,catalytic activity,Pf00328,51205,ENSG00000162836.11,ACP6; LOC101060704,1,,,,0,High,1
Q6P087,Mitochondrial mRNA pseudouridine synthase RPUSD3 OS=Homo sapiens OX=9606 GN=RPUSD3 PE=1 SV=3,0,29.557,19,5,15,5,351,38.4,10.32,5771,,5,,metabolic process,mitochondrion;organelle lumen,catalytic activity;protein binding;RNA binding,Pf00849,285367,ENSG00000156990.14,RPUSD3,3,,,,0,High,1
Q9UNK0,Syntaxin-8 OS=Homo sapiens OX=9606 GN=STX8 PE=1 SV=2,0,29.52,28,6,18,6,236,26.9,4.98,6445,,6,,cell organization and biogenesis;regulation of biological process;transport,cytosol;endoplasmic reticulum;endosome;membrane,protein binding,Pf05739,9482,ENSG00000170310.14,STX8,17,SNARE interactions in vesicular transport,,,1,High,1
Q13797,Integrin alpha-9 OS=Homo sapiens OX=9606 GN=ITGA9 PE=1 SV=2,0,29.514,10,5,36,5,1035,114.4,6.14,12398,0,5,1,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,membrane,metal ion binding;protein binding,"Pf01839, Pf08441, Pf13517, Pf14312",3680,ENSG00000144668.11,ITGA9,3,PI3K-Akt signaling pathway; Cell adhesion molecules (CAMs); Regulation of actin cytoskeleton; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Hypertrophic cardiomyopathy (HCM); ECM-receptor interaction; Focal adhesion; Dilated cardiomyopathy,Integrin-mediated Cell Adhesion; Arrhythmogenic Right Ventricular Cardiomyopathy; Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,ECM proteoglycans; Integrin cell surface interactions; Signal transduction by L1,19,High,1
Q14019,Coactosin-like protein OS=Homo sapiens OX=9606 GN=COTL1 PE=1 SV=3,0,29.508,32,5,38,5,142,15.9,5.67,20641,,5,,defense response;response to stimulus;transport,cytoplasm;cytoskeleton;extracellular;nucleus;organelle lumen,protein binding,"Pf00241, Pf01453",23406,ENSG00000103187.7,COTL1,16,,,Neutrophil degranulation,3,High,1
Q9Y3R5,Protein dopey-2 OS=Homo sapiens OX=9606 GN=DOP1B PE=1 SV=5,0,29.505,4,7,19,7,2298,258.1,6.29,8280,,7,,cell organization and biogenesis;development;transport,cytosol;endosome;membrane,,Pf04118,9980,ENSG00000142197.12,DOPEY2,21,,,,0,High,1
Q9BY11,Protein kinase C and casein kinase substrate in neurons protein 1 OS=Homo sapiens OX=9606 GN=PACSIN1 PE=1 SV=1,0,29.493,20,6,14,6,444,50.9,5.24,5139,,6,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;endosome;membrane,catalytic activity;protein binding,"Pf00018, Pf00611, Pf07653, Pf14604",29993,ENSG00000124507.10,PACSIN1,6,,,Clathrin-mediated endocytosis,3,High,1
O14656,Torsin-1A OS=Homo sapiens OX=9606 GN=TOR1A PE=1 SV=1,0,29.468,31,7,21,7,332,37.8,6.99,9169,,7,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;nucleus;organelle lumen,catalytic activity;nucleotide binding;protein binding,Pf06309,1861,ENSG00000136827.11,TOR1A,9,,,Cargo recognition for clathrin-mediated endocytosis,4,High,1
Q7L7X3,Serine/threonine-protein kinase TAO1 OS=Homo sapiens OX=9606 GN=TAOK1 PE=1 SV=1,0,29.358,8,7,28,4,1001,116,7.65,10649,,7,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,catalytic activity;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf02463, Pf03938, Pf03961, Pf07714, Pf09726, Pf12128, Pf12474, Pf14531",57551,ENSG00000160551.11,TAOK1,17,MAPK signaling pathway,Regulation of Microtubule Cytoskeleton; MAPK Signaling Pathway,Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins,19,High,1
O95777,U6 snRNA-associated Sm-like protein LSm8 OS=Homo sapiens OX=9606 GN=LSM8 PE=1 SV=3,0,29.329,74,6,45,6,96,10.4,4.48,17849,,6,,metabolic process,nucleus;spliceosomal complex,protein binding;RNA binding,Pf01423,51691,ENSG00000128534.7,NAA38; LSM8,7,RNA degradation; Spliceosome,,mRNA Splicing - Major Pathway,6,High,1
Q9BXV9,EKC/KEOPS complex subunit GON7 OS=Homo sapiens OX=9606 GN=GON7 PE=1 SV=2,0,29.31,60,3,17,3,100,10.9,4.27,8620,,3,,,nucleus,protein binding,Pf15387,84520,ENSG00000275619.2; ENSG00000170270.4,C14orf142; GON7,14; CHR_HSCHR14_7_CTG1,,,,0,High,1
Q16629,Serine/arginine-rich splicing factor 7 OS=Homo sapiens OX=9606 GN=SRSF7 PE=1 SV=1,0,29.308,22,6,51,5,238,27.4,11.82,22242,,6,,metabolic process;regulation of biological process;transport,cytoplasm;nucleus,metal ion binding;protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",6432,ENSG00000115875.18,SRSF7,2,Herpes simplex infection; Spliceosome,mRNA Processing,Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway,15,High,1
Q9H000,Probable E3 ubiquitin-protein ligase makorin-2 OS=Homo sapiens OX=9606 GN=MKRN2 PE=1 SV=2,0,29.305,11,5,15,5,416,46.9,7.61,7047,,5,,metabolic process,,catalytic activity;metal ion binding;protein binding;RNA binding,"Pf00097, Pf00642, Pf13639",23609,ENSG00000075975.15,MKRN2,3,,,,0,High,1
Q8N428,Polypeptide N-acetylgalactosaminyltransferase 16 OS=Homo sapiens OX=9606 GN=GALNT16 PE=1 SV=2,0,29.301,15,6,16,6,558,63,9.13,6524,2.61,5,1,metabolic process,Golgi;membrane,catalytic activity;metal ion binding,"Pf00535, Pf00652, Pf02709",57452,ENSG00000100626.16,GALNT16; GALNTL1,14,Metabolic pathways; Mucin type O-glycan biosynthesis,,O-linked glycosylation of mucins,6,High,1
Q9NZT1,Calmodulin-like protein 5 OS=Homo sapiens OX=9606 GN=CALML5 PE=1 SV=2,0,29.251,41,5,25,5,146,15.9,4.44,11186,,5,,regulation of biological process;response to stimulus;transport,extracellular,metal ion binding;protein binding,"Pf00036, Pf12763, Pf13202, Pf13405, Pf13499, Pf13833",51806,ENSG00000178372.7,CALML5,10,Adrenergic signaling in cardiomyocytes; Calcium signaling pathway; Circadian entrainment; Ras signaling pathway; Renin secretion; Oocyte meiosis; Vascular smooth muscle contraction; Pertussis; Glioma; cAMP signaling pathway; Oxytocin signaling pathway; Inflammatory mediator regulation of TRP channels; Amphetamine addiction; Alzheimer's disease; Dopaminergic synapse; Tuberculosis; Neurotrophin signaling pathway; Gastric acid secretion; Phosphatidylinositol signaling system; Estrogen signaling pathway; cGMP-PKG signaling pathway; Aldosterone synthesis and secretion; Long-term potentiation; GnRH signaling pathway; Insulin signaling pathway; Melanogenesis; Olfactory transduction; Alcoholism; Phototransduction; Glucagon signaling pathway; Rap1 signaling pathway; Salivary secretion,Alzheimers Disease,Neutrophil degranulation,36,High,1
Q86Y79,Probable peptidyl-tRNA hydrolase OS=Homo sapiens OX=9606 GN=PTRH1 PE=1 SV=1,0,29.233,29,4,21,4,214,22.9,10.56,8695,,4,,,mitochondrion,catalytic activity;protein binding;RNA binding,Pf01195,138428,ENSG00000187024.13,PTRH1,9,,,,0,High,1
P63173,60S ribosomal protein L38 OS=Homo sapiens OX=9606 GN=RPL38 PE=1 SV=2,0,29.222,41,4,118,4,70,8.2,10.1,59828,,4,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytosol;ribosome,RNA binding;structural molecule activity,Pf01781,6169,ENSG00000172809.12,RPL38,17,Ribosome,Mesodermal Commitment Pathway; Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,35,High,1
Q99720,Sigma non-opioid intracellular receptor 1 OS=Homo sapiens OX=9606 GN=SIGMAR1 PE=1 SV=1,0,29.218,32,4,14,4,223,25.1,5.96,6665,,4,,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;membrane;nucleus,protein binding;receptor activity;signal transducer activity,Pf04622,10280,ENSG00000147955.16,SIGMAR1,9,,,,0,High,1
A6NJ78,Probable methyltransferase-like protein 15 OS=Homo sapiens OX=9606 GN=METTL15 PE=1 SV=1,0,29.213,16,6,13,6,407,46.1,8.62,5129,,6,,metabolic process,,catalytic activity;protein binding,"Pf01795, Pf13659",196074,ENSG00000169519.20,METTL15,11,,,,0,High,1
Q96S55,ATPase WRNIP1 OS=Homo sapiens OX=9606 GN=WRNIP1 PE=1 SV=2,0,29.169,10,6,15,6,665,72.1,6.1,5620,0,6,1,metabolic process;regulation of biological process;response to stimulus,membrane;nucleus,catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding,"Pf00004, Pf00006, Pf00308, Pf00910, Pf03215, Pf04851, Pf05496, Pf07724, Pf07728, Pf12002, Pf13173, Pf13177, Pf13191, Pf13401",56897,ENSG00000124535.15,WRNIP1,6,,,,0,High,1
Q86XA9,HEAT repeat-containing protein 5A OS=Homo sapiens OX=9606 GN=HEATR5A PE=1 SV=2,0,29.144,5,6,16,6,2040,221.9,6.58,6451,,6,,,,,,25938,,HEATR5A,14,,,,0,High,1
Q15125,"3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase OS=Homo sapiens OX=9606 GN=EBP PE=1 SV=3",0,29.14,11,3,35,3,230,26.3,7.9,16201,,3,,metabolic process;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;membrane;nucleus,catalytic activity;protein binding;receptor activity;signal transducer activity;transporter activity,Pf05241,10682,ENSG00000147155.10,EBP,X,Metabolic pathways; Steroid biosynthesis,,Cholesterol biosynthesis via desmosterol; Cholesterol biosynthesis via lathosterol,8,High,1
O15042,U2 snRNP-associated SURP motif-containing protein OS=Homo sapiens OX=9606 GN=U2SURP PE=1 SV=2,0,29.115,11,8,20,8,1029,118.2,8.47,6676,,8,,metabolic process,nucleus,protein binding;RNA binding,"Pf00076, Pf01805, Pf08312, Pf13893, Pf14259",23350,ENSG00000163714.17,U2SURP,3,Spliceosome,,mRNA Splicing - Major Pathway,5,High,1
Q9UM00,Calcium load-activated calcium channel OS=Homo sapiens OX=9606 GN=TMCO1 PE=1 SV=2,0,29.109,15,3,53,3,239,27.1,10.26,21562,0,3,1,,,,,,,,,,,,0,High,1
P63279,SUMO-conjugating enzyme UBC9 OS=Homo sapiens OX=9606 GN=UBE2I PE=1 SV=1,0,29.105,20,4,98,4,158,18,8.66,42215,,4,,cell division;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00179, Pf14461",7329,ENSG00000103275.19,UBE2I,16,RNA transport; Ubiquitin mediated proteolysis; NF-kappa B signaling pathway; MicroRNAs in cancer,Androgen receptor signaling pathway; TGF-beta Signaling Pathway,"SUMOylation of DNA replication proteins; SUMOylation of RNA binding proteins; Meiotic synapsis; Negative regulation of activity of TFAP2 (AP-2) family transcription factors; SUMOylation of chromatin organization proteins; Formation of Incision Complex in GG-NER; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; SUMOylation of transcription factors; SUMOylation of DNA damage response and repair proteins; SUMO is transferred from E1 to E2 (UBE2I, UBC9)",36,High,1
Q96S44,EKC/KEOPS complex subunit TP53RK OS=Homo sapiens OX=9606 GN=TP53RK PE=1 SV=2,0,29.041,23,4,35,4,253,28.1,9.54,17071,,4,,metabolic process;regulation of biological process,cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf01163, Pf01636, Pf06293",112858,ENSG00000172315.5,TP53RK,20,,,tRNA modification in the nucleus and cytosol; Regulation of TP53 Activity through Phosphorylation,9,High,1
Q9NPY3,Complement component C1q receptor OS=Homo sapiens OX=9606 GN=CD93 PE=1 SV=3,0,29.039,9,4,25,4,652,68.5,5.44,10952,6.13,3,1,transport,cell surface;membrane,metal ion binding;protein binding;receptor activity,"Pf00059, Pf06247, Pf07645, Pf12662, Pf12947, Pf14670",22918,ENSG00000125810.9,CD93,20,,,Neutrophil degranulation,3,High,1
O75051,Plexin-A2 OS=Homo sapiens OX=9606 GN=PLXNA2 PE=1 SV=4,0,29.028,4,7,21,5,1894,211,6.48,8812,,7,,cellular component movement;regulation of biological process;response to stimulus,membrane,protein binding;receptor activity;signal transducer activity,"Pf01403, Pf01437, Pf01833, Pf08337",5362,ENSG00000076356.6,PLXNA2,1,Axon guidance,Spinal Cord Injury; Ectoderm Differentiation,SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Other semaphorin interactions; Sema3A PAK dependent Axon repulsion; CRMPs in Sema3A signaling,10,High,1
Q8N1G2,Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 OS=Homo sapiens OX=9606 GN=CMTR1 PE=1 SV=1,0,29.007,9,7,20,6,835,95.3,7.05,8594,,7,,metabolic process,cytosol;nucleus,catalytic activity;protein binding,"Pf01585, Pf01728",23070,ENSG00000137200.12,CMTR1; FTSJD2,6,,,,0,High,1
Q9Y6N6,Laminin subunit gamma-3 OS=Homo sapiens OX=9606 GN=LAMC3 PE=1 SV=3,0,28.965,2,3,86,1,1575,171.1,6.58,43284,19.17,3,1,cell organization and biogenesis,extracellular;membrane,structural molecule activity,"Pf00052, Pf00053, Pf00055, Pf13514",10319,ENSG00000050555.17,LAMC3,9,Small cell lung cancer; PI3K-Akt signaling pathway; Toxoplasmosis; Amoebiasis; ECM-receptor interaction; Focal adhesion; Pathways in cancer,Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,Laminin interactions; MET activates PTK2 signaling; Non-integrin membrane-ECM interactions,17,High,1
Q9Y3U8,60S ribosomal protein L36 OS=Homo sapiens OX=9606 GN=RPL36 PE=1 SV=3,0,28.951,20,3,88,3,105,12.2,11.59,44002,,3,,cell organization and biogenesis;metabolic process;transport,cytoplasm;cytosol;membrane;ribosome,RNA binding;structural molecule activity,Pf01158,25873,ENSG00000130255.12,RPL36,19,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
Q8N8Q8,"Cytochrome c oxidase assembly protein COX18, mitochondrial OS=Homo sapiens OX=9606 GN=COX18 PE=1 SV=1",0,28.944,22,6,35,6,333,37,9.83,12900,,6,,cell organization and biogenesis;transport,membrane;mitochondrion,transporter activity,Pf02096,285521,ENSG00000163626.16,COX18,4,,,TP53 Regulates Metabolic Genes; Respiratory electron transport,9,High,1
P01717,Immunoglobulin lambda variable 3-25 OS=Homo sapiens OX=9606 GN=IGLV3-25 PE=1 SV=2,0,28.939,44,4,37,2,112,12,4.5,16392,,4,,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity,Pf07686,28793,ENSG00000211659.2,IGLV3-25,22,,,FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis,26,High,1
P35269,General transcription factor IIF subunit 1 OS=Homo sapiens OX=9606 GN=GTF2F1 PE=1 SV=2,0,28.919,15,6,16,6,517,58.2,7.49,5964,,6,,metabolic process;regulation of biological process;response to stimulus,nucleus,catalytic activity;DNA binding;enzyme regulator activity;protein binding;RNA binding,Pf05793,2962,ENSG00000125651.13,GTF2F1,19,Basal transcription factors,,Signaling by FGFR2 IIIa TM; RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; Formation of HIV-1 elongation complex containing HIV-1 Tat; Formation of the HIV-1 Early Elongation Complex; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; TP53 Regulates Transcription of DNA Repair Genes; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; RNA Polymerase II HIV Promoter Escape; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; Pausing and recovery of HIV elongation; RNA Polymerase II Promoter Escape; HIV elongation arrest and recovery; RNA Pol II CTD phosphorylation and interaction with CE; Viral Messenger RNA Synthesis; RNA Polymerase II Transcription Initiation; mRNA Capping; Pausing and recovery of Tat-mediated HIV elongation; Formation of the Early Elongation Complex,55,High,1
Q9BRQ8,Apoptosis-inducing factor 2 OS=Homo sapiens OX=9606 GN=AIFM2 PE=1 SV=1,0,28.91,23,5,15,5,373,40.5,9.11,7231,,5,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;mitochondrion,catalytic activity;DNA binding;nucleotide binding,"Pf00070, Pf07992",84883,ENSG00000042286.14,AIFM2,10,,Apoptosis Modulation and Signaling,TP53 Regulates Transcription of Genes Involved in Cytochrome C Release,7,High,1
Q96A73,Putative monooxygenase p33MONOX OS=Homo sapiens OX=9606 GN=KIAA1191 PE=1 SV=1,0,28.884,35,7,25,7,305,33.2,9.39,8740,,7,,metabolic process,cytoplasm,catalytic activity;protein binding,Pf15302,57179,ENSG00000122203.14,KIAA1191,5,,,,0,High,1
Q9P2A4,ABI gene family member 3 OS=Homo sapiens OX=9606 GN=ABI3 PE=1 SV=2,0,28.866,21,6,24,6,366,39,5.08,9748,,6,,cellular component movement;metabolic process;regulation of biological process,cytoplasm;membrane,protein binding,"Pf00018, Pf07653, Pf07815, Pf14604",51225,ENSG00000108798.8,ABI3,17,,,,0,High,1
Q9BRR6,ADP-dependent glucokinase OS=Homo sapiens OX=9606 GN=ADPGK PE=1 SV=1,0,28.861,16,5,22,5,497,54.1,6.2,9170,,5,,metabolic process,endoplasmic reticulum;extracellular;membrane,catalytic activity;metal ion binding,Pf04587,83440,,ADPGK,15,Glycolysis / Gluconeogenesis; Metabolic pathways; Carbon metabolism,,Glycolysis,7,High,1
Q5JVS0,Intracellular hyaluronan-binding protein 4 OS=Homo sapiens OX=9606 GN=HABP4 PE=1 SV=1,0,28.854,10,4,22,3,413,45.8,7.46,8116,,4,,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;nucleus,protein binding;RNA binding,Pf04774,22927,ENSG00000130956.13,HABP4,9,,,Platelet degranulation,4,High,1
Q96ME1-4,Isoform 4 of F-box/LRR-repeat protein 18 OS=Homo sapiens OX=9606 GN=FBXL18,0,28.851,14,7,16,7,718,78.9,8.27,4828,4.28,6,1,metabolic process,cytosol,catalytic activity;protein binding,Pf12937,80028,ENSG00000155034.18,FBXL18,7,,,,0,High,1
Q9BY32,Inosine triphosphate pyrophosphatase OS=Homo sapiens OX=9606 GN=ITPA PE=1 SV=2,0,28.767,22,3,60,3,194,21.4,5.66,24192,,3,,cell organization and biogenesis;metabolic process,cytoplasm;cytosol,catalytic activity;metal ion binding;nucleotide binding;protein binding,Pf01725,3704,ENSG00000125877.12,ITPA,20,Purine metabolism; Drug metabolism - other enzymes; Metabolic pathways,,Purine catabolism,7,High,1
Q05655,Protein kinase C delta type OS=Homo sapiens OX=9606 GN=PRKCD PE=1 SV=2,0,28.757,7,5,22,5,676,77.5,7.75,11193,,5,,cell death;cell organization and biogenesis;cell proliferation;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;extracellular;membrane;nucleus;organelle lumen,catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf00130, Pf00433, Pf07714, Pf14531",5580,ENSG00000163932.13,PRKCD,3,AGE-RAGE signaling pathway in diabetic complications; Vascular smooth muscle contraction; Estrogen signaling pathway; Fc gamma R-mediated phagocytosis; Type II diabetes mellitus; Tight junction; Chemokine signaling pathway; Inflammatory mediator regulation of TRP channels; Neurotrophin signaling pathway; NOD-like receptor signaling pathway; Insulin resistance; GnRH signaling pathway,Type II diabetes mellitus; miRs in Muscle Cell Differentiation; Signaling Pathways in Glioblastoma; B Cell Receptor Signaling Pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Alpha 6 Beta 4 signaling pathway; Myometrial Relaxation and Contraction Pathways; G Protein Signaling Pathways; IL-6 signaling pathway; MAPK Signaling Pathway; VEGFA-VEGFR2 Signaling Pathway; Chemokine signaling pathway; Wnt Signaling Pathway and Pluripotency; Wnt Signaling Pathway; EGF/EGFR Signaling Pathway; Insulin Signaling; Calcium Regulation in the Cardiac Cell; Type II interferon signaling (IFNG); T-Cell antigen Receptor (TCR)  Signaling Pathway,G alpha (z) signalling events; SHC1 events in ERBB2 signaling; Interferon gamma signaling; Apoptotic cleavage of cellular proteins; Effects of PIP2 hydrolysis; Neutrophil degranulation; Gastrin-CREB signalling pathway via PKC and MAPK; VEGFR2 mediated cell proliferation; HuR (ELAVL1) binds and stabilizes mRNA; Calmodulin induced events; CLEC7A (Dectin-1) signaling; Role of phospholipids in phagocytosis,74,High,1
Q9UHQ4,B-cell receptor-associated protein 29 OS=Homo sapiens OX=9606 GN=BCAP29 PE=1 SV=2,0,28.756,21,5,69,5,241,28.3,9.54,28507,3.79,4,1,cell death;cell differentiation;cellular component movement;metabolic process;transport,endoplasmic reticulum;membrane,,"Pf04111, Pf05529, Pf09731, Pf13851",55973,ENSG00000075790.10; ENSG00000283852.1,BCAP29,7; CHR_HG2266_PATCH,,,,0,High,1
O14494-2,Isoform 2 of Phospholipid phosphatase 1 OS=Homo sapiens OX=9606 GN=PLPP1,0,28.752,19,3,26,3,285,32.1,8.16,10448,7.58,2,1,cellular component movement;metabolic process;regulation of biological process;response to stimulus,membrane,catalytic activity,Pf01569,8611,ENSG00000067113.16,PPAP2A; PLPP1,5,,Androgen receptor signaling pathway; Sphingolipid Metabolism; Triacylglyceride Synthesis,,3,High,1
Q01970,"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 OS=Homo sapiens OX=9606 GN=PLCB3 PE=1 SV=2",0,28.746,6,7,30,7,1234,138.7,5.9,11424,,7,,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoskeleton;cytosol;membrane,catalytic activity;metal ion binding;motor activity;protein binding;signal transducer activity,"Pf00168, Pf00387, Pf00388, Pf01576, Pf05262, Pf05672, Pf07321, Pf08703, Pf09279, Pf10186, Pf12037",5331,ENSG00000149782.11,PLCB3,11,NOD-like receptor signaling pathway; Phosphatidylinositol signaling system; Inflammatory mediator regulation of TRP channels; Pathways in cancer; Aldosterone synthesis and secretion; Rap1 signaling pathway; Melanogenesis; African trypanosomiasis; Glutamatergic synapse; AGE-RAGE signaling pathway in diabetic complications; Metabolic pathways; Serotonergic synapse; Insulin secretion; Gastric acid secretion; Circadian entrainment; Alzheimer's disease; Renin secretion; Thyroid hormone synthesis; Cholinergic synapse; Dopaminergic synapse; Long-term potentiation; Retrograde endocannabinoid signaling; Phospholipase D signaling pathway; Inositol phosphate metabolism; Chemokine signaling pathway; Endocrine and other factor-regulated calcium reabsorption; Long-term depression; Vascular smooth muscle contraction; Adrenergic signaling in cardiomyocytes; GnRH signaling pathway; Oxytocin signaling pathway; Wnt signaling pathway; Platelet activation; Amoebiasis; Gap junction; Salivary secretion; Huntington's disease; Pancreatic secretion; Calcium signaling pathway; Chagas disease (American trypanosomiasis); Thyroid hormone signaling pathway; Sphingolipid signaling pathway; cGMP-PKG signaling pathway; Glucagon signaling pathway; Estrogen signaling pathway,Alzheimers Disease; Signal Transduction of S1P Receptor; Myometrial Relaxation and Contraction Pathways; G Protein Signaling Pathways; VEGFA-VEGFR2 Signaling Pathway; Chemokine signaling pathway; GPR40 PATHWAY; MAPK Cascade; Calcium Regulation in the Cardiac Cell,PLC beta mediated events; Acetylcholine regulates insulin secretion; Ca2+ pathway; Presynaptic function of Kainate receptors; G beta:gamma signalling through PLC beta; Synthesis of IP3 and IP4 in the cytosol; Gastrin-CREB signalling pathway via PKC and MAPK; Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion,80,High,1
P62256,Ubiquitin-conjugating enzyme E2 H OS=Homo sapiens OX=9606 GN=UBE2H PE=1 SV=1,0,28.726,23,4,51,4,183,20.6,4.67,18309,,4,,metabolic process,cytoplasm;cytosol,catalytic activity;nucleotide binding;protein binding,Pf00179,7328,ENSG00000186591.11,UBE2H,7,Ubiquitin mediated proteolysis,,Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation,9,High,1
Q99755,Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha OS=Homo sapiens OX=9606 GN=PIP5K1A PE=1 SV=1,0,28.719,14,5,23,4,562,62.6,8.21,8898,,5,,cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding,Pf01504,8394,ENSG00000143398.19,PIP5K1A,1,Endocytosis; Metabolic pathways; Inositol phosphate metabolism; Regulation of actin cytoskeleton; Phospholipase D signaling pathway; Fc gamma R-mediated phagocytosis; Choline metabolism in cancer; Phosphatidylinositol signaling system,B Cell Receptor Signaling Pathway; Regulation of Actin Cytoskeleton,"Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling",20,High,1
P16949,Stathmin OS=Homo sapiens OX=9606 GN=STMN1 PE=1 SV=3,0,28.714,22,4,41,4,149,17.3,5.97,18844,,4,,cell differentiation;cell organization and biogenesis;development;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane,protein binding;signal transducer activity,"Pf00836, Pf09726",3925,ENSG00000117632.22,STMN1,1,MAPK signaling pathway; MicroRNAs in cancer,Regulation of Microtubule Cytoskeleton; Retinoblastoma (RB) in Cancer; Rac1/Pak1/p38/MMP-2 pathway; MAPK Signaling Pathway; EGF/EGFR Signaling Pathway,,7,High,1
A0A0C4DH42,Immunoglobulin heavy variable 3-66 OS=Homo sapiens OX=9606 GN=IGHV3-66 PE=3 SV=1,0,28.703,26,4,66,3,116,12.7,8.16,31787,,4,,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,protein binding,,28412,ENSG00000211972.2; ENSG00000282045.1,IGHV3-66,14; CHR_HSCHR14_3_CTG1,,,,0,High,1
Q9NZ09,Ubiquitin-associated protein 1 OS=Homo sapiens OX=9606 GN=UBAP1 PE=1 SV=1,0,28.693,20,5,25,5,502,55,5.11,10269,,5,,metabolic process;transport,cytoplasm;cytosol;endosome;Golgi;membrane,protein binding,,51271,ENSG00000165006.13,UBAP1,9,,,Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); Membrane binding and targetting of GAG proteins,12,High,1
P23921,Ribonucleoside-diphosphate reductase large subunit OS=Homo sapiens OX=9606 GN=RRM1 PE=1 SV=1,0,28.691,12,7,20,7,792,90,7.15,5396,,7,,metabolic process,cytoplasm;cytosol,catalytic activity;nucleotide binding;protein binding,"Pf00317, Pf02867, Pf03477",6240,ENSG00000167325.14,RRM1,11,Purine metabolism; Metabolic pathways; Glutathione metabolism; Pyrimidine metabolism,Fluoropyrimidine Activity; Retinoblastoma (RB) in Cancer; Nucleotide Metabolism,Interconversion of nucleotide di- and triphosphates,10,High,1
Q9UBF9,Myotilin OS=Homo sapiens OX=9606 GN=MYOT PE=1 SV=2,0,28.653,12,5,19,5,498,55.4,9.07,9934,,5,,,cytoplasm;cytoskeleton;membrane,protein binding;structural molecule activity,"Pf00047, Pf07679, Pf13895, Pf13927",9499,,MYOT,5,,,,0,High,1
Q9Y4K3,TNF receptor-associated factor 6 OS=Homo sapiens OX=9606 GN=TRAF6 PE=1 SV=1,0,28.633,13,5,15,5,522,59.5,6.44,7383,,5,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,catalytic activity;metal ion binding;motor activity;protein binding,"Pf00097, Pf00917, Pf01576, Pf02176, Pf13639, Pf13920, Pf13923, Pf15227",7189,ENSG00000175104.14,TRAF6,11,Chagas disease (American trypanosomiasis); Toll-like receptor signaling pathway; Tuberculosis; Leishmaniasis; NOD-like receptor signaling pathway; Hepatitis C; Measles; Pathways in cancer; Epstein-Barr virus infection; Pertussis; Osteoclast differentiation; RIG-I-like receptor signaling pathway; NF-kappa B signaling pathway; Endocytosis; Herpes simplex infection; MAPK signaling pathway; Small cell lung cancer; Neurotrophin signaling pathway; Toxoplasmosis; Ubiquitin mediated proteolysis,Regulation of toll-like receptor signaling pathway; IL-1 signaling pathway; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; IL17 signaling pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; EBV LMP1 signaling; Structural Pathway of Interleukin 1 (IL-1); Melatonin metabolism and effects; Photodynamic therapy-induced NF-kB survival signaling; Interleukin-1 Induced Activation of NF-kappa-B; TGF-beta Signaling Pathway; MAPK Signaling Pathway; MAPK  and NFkB Signalling Pathways Inhibited by Yersinia YopJ; TLR4 Signaling and Tolerance; Toll-like Receptor Signaling; RIG-I-like Receptor Signaling; Simplified Depiction of MYD88 Distinct Input-Output Pathway; Oxidative Damage; T-Cell antigen Receptor (TCR)  Signaling Pathway; Toll-like receptor signaling pathway,"IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulated proteolysis of p75NTR; Downstream TCR signaling; NOD1/2 Signaling Pathway; TRAF6 mediated NF-kB activation; TRAF6 mediated IRF7 activation; TICAM1, RIP1-mediated IKK complex recruitment ; TRAF6-mediated induction of TAK1 complex within TLR4 complex; Ovarian tumor domain proteases; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Activated TLR4 signalling; Interleukin-1 family signaling; IRAK1 recruits IKK complex; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling; activated TAK1 mediates p38 MAPK activation; TICAM1,TRAF6-dependent induction of TAK1 complex; p75NTR recruits signalling complexes; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Ub-specific processing proteases; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; IKK complex recruitment mediated by RIP1; IRAK2 mediated activation of TAK1 complex; FCERI mediated NF-kB activation; NRIF signals cell death from the nucleus; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NF-kB is activated and signals survival; Signalling by NGF; CLEC7A (Dectin-1) signaling",107,High,1
Q96GZ6,Solute carrier family 41 member 3 OS=Homo sapiens OX=9606 GN=SLC41A3 PE=1 SV=2,0,28.599,18,5,21,4,507,54.7,7.83,7348,,5,,transport,membrane,protein binding;transporter activity,Pf01769,54946,ENSG00000114544.16,SLC41A3,3,,,,0,High,1
P02747,Complement C1q subcomponent subunit C OS=Homo sapiens OX=9606 GN=C1QC PE=1 SV=3,0,28.591,21,4,56,4,245,25.8,8.41,27993,0,4,1,defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,catalytic activity;protein binding,"Pf00229, Pf00386",714,ENSG00000159189.11,C1QC,1,Systemic lupus erythematosus; Prion diseases; Complement and coagulation cascades; Chagas disease (American trypanosomiasis); Staphylococcus aureus infection; Pertussis,Allograft Rejection; Microglia Pathogen Phagocytosis Pathway; Oxidative Damage; TYROBP Causal Network; Complement Activation; Complement and Coagulation Cascades,Regulation of Complement cascade; Classical antibody-mediated complement activation,19,High,1
O95208,Epsin-2 OS=Homo sapiens OX=9606 GN=EPN2 PE=1 SV=3,0,28.542,17,7,36,6,641,68.4,7.52,13564,,7,,cell organization and biogenesis;transport,cytoplasm;cytosol,protein binding,"Pf01417, Pf07651",22905,ENSG00000072134.15,EPN2,17,Endocytosis,,Cargo recognition for clathrin-mediated endocytosis,5,High,1
Q99417,c-Myc-binding protein OS=Homo sapiens OX=9606 GN=MYCBP PE=1 SV=3,0,28.527,71,6,26,6,103,12,5.91,9852,,6,,metabolic process;regulation of biological process,cytoplasm;cytosol;mitochondrion;nucleus,protein binding,,26292,ENSG00000214114.8,MYCBP,1,,Pathways Affected in Adenoid Cystic Carcinoma,,1,High,1
Q9UMZ2,Synergin gamma OS=Homo sapiens OX=9606 GN=SYNRG PE=1 SV=2,0,28.516,6,6,16,6,1314,140.6,5.03,8280,,6,,transport,cytoplasm;Golgi;membrane,protein binding,,11276,ENSG00000275066.4; ENSG00000274047.4,SYNRG,17; CHR_HSCHR17_7_CTG4,,,,0,High,1
P49407,Beta-arrestin-1 OS=Homo sapiens OX=9606 GN=ARRB1 PE=1 SV=2,0,28.512,21,6,26,5,418,47,6.2,10654,,6,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,chromosome;cytoplasm;cytosol;membrane;nucleus,catalytic activity;DNA binding;enzyme regulator activity;protein binding,"Pf00339, Pf02752",408,ENSG00000137486.16,ARRB1,11,MAPK signaling pathway; Hedgehog signaling pathway; Olfactory transduction; Endocytosis; Chemokine signaling pathway; Morphine addiction,Corticotropin-releasing hormone signaling pathway; Myometrial Relaxation and Contraction Pathways; MAPK Signaling Pathway; Chemokine signaling pathway; Calcium Regulation in the Cardiac Cell,Cargo recognition for clathrin-mediated endocytosis; Activated NOTCH1 Transmits Signal to the Nucleus; G alpha (s) signalling events; Signaling by BRAF and RAF fusions; Ub-specific processing proteases; MAP2K and MAPK activation; Golgi Associated Vesicle Biogenesis; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Lysosome Vesicle Biogenesis; Signaling by moderate kinase activity BRAF mutants; Thrombin signalling through proteinase activated receptors (PARs); Paradoxical activation of RAF signaling by kinase inactive BRAF; Activation of SMO; Interleukin-20 family signaling,52,High,1
Q96KA5,Cleft lip and palate transmembrane protein 1-like protein OS=Homo sapiens OX=9606 GN=CLPTM1L PE=1 SV=1,0,28.491,13,5,27,5,538,62.2,8.56,13120,,5,,cell death,membrane,,Pf05602,81037,ENSG00000274811.3; ENSG00000049656.13,CLPTM1L,5; CHR_HSCHR5_3_CTG1,,,,0,High,1
O60725,Protein-S-isoprenylcysteine O-methyltransferase OS=Homo sapiens OX=9606 GN=ICMT PE=1 SV=1,0,28.491,15,4,71,4,284,31.9,7.96,38487,,4,,cell organization and biogenesis;metabolic process;transport,endoplasmic reticulum;membrane,catalytic activity,"Pf04140, Pf04191",23463,ENSG00000116237.15,ICMT,1,Terpenoid backbone biosynthesis,,"Gamma carboxylation, hypusine formation and arylsulfatase activation",4,High,1
Q9H2P9,Diphthine methyl ester synthase OS=Homo sapiens OX=9606 GN=DPH5 PE=1 SV=2,0,28.472,19,4,30,4,285,31.6,5.31,14206,,4,,metabolic process,cytosol,catalytic activity,Pf00590,51611,ENSG00000117543.20,DPH5,1,,,Synthesis of diphthamide-EEF2,4,High,1
O14562,Ubiquitin domain-containing protein UBFD1 OS=Homo sapiens OX=9606 GN=UBFD1 PE=1 SV=2,0,28.468,31,6,40,6,309,33.4,5.77,12894,,6,,,,protein binding;RNA binding,"Pf00240, Pf14560",56061,ENSG00000103353.15,UBFD1,16,,,,0,High,1
P55769,NHP2-like protein 1 OS=Homo sapiens OX=9606 GN=SNU13 PE=1 SV=3,0,28.465,30,5,35,5,128,14.2,8.46,13807,,5,,cell organization and biogenesis;metabolic process,nucleus;spliceosomal complex,protein binding;RNA binding,Pf01248,4809,ENSG00000100138.13,NHP2L1; SNU13,22,Spliceosome; Ribosome biogenesis in eukaryotes,mRNA Processing,Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway,12,High,1
P80723,Brain acid soluble protein 1 OS=Homo sapiens OX=9606 GN=BASP1 PE=1 SV=2,0,28.459,44,5,18,5,227,22.7,4.63,9073,,5,,cell differentiation;cell organization and biogenesis;regulation of biological process,cytoplasm;cytoskeleton;membrane;nucleus,DNA binding;protein binding,,10409,ENSG00000176788.8,BASP1,5,,,,0,High,1
Q8NE22,SET domain-containing protein 9 OS=Homo sapiens OX=9606 GN=SETD9 PE=2 SV=2,0,28.456,18,4,25,4,299,34.1,8.76,11730,,4,,metabolic process;regulation of biological process,,catalytic activity;protein binding,Pf00856,133383,ENSG00000155542.11,SETD9,5,,Histone Modifications,Regulation of TP53 Activity through Methylation,7,High,1
Q9UQ88,Cyclin-dependent kinase 11A OS=Homo sapiens OX=9606 GN=CDK11A PE=1 SV=4,0,28.433,9,7,86,6,783,91.3,5.36,33425,,7,,cell death;metabolic process;regulation of biological process,cytoplasm;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf07714, Pf14531",728642,ENSG00000008128.22,CDK11A,1,,,Recruitment of mitotic centrosome proteins and complexes,6,High,1
Q9H446,RWD domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RWDD1 PE=1 SV=1,0,28.399,14,3,28,3,243,27.9,4.2,15514,,3,,metabolic process;regulation of biological process;response to stimulus,cytoplasm,protein binding,Pf05773,51389,ENSG00000111832.12,RWDD1,6,,,,0,High,1
Q9C0D3,Protein zyg-11 homolog B OS=Homo sapiens OX=9606 GN=ZYG11B PE=1 SV=2,0,28.377,10,5,20,5,744,83.9,6.86,8805,2.5,4,1,metabolic process;regulation of biological process,,catalytic activity;protein binding,Pf12799,79699,ENSG00000162378.12,ZYG11B,1,,,,0,High,1
Q8TEC5,E3 ubiquitin-protein ligase SH3RF2 OS=Homo sapiens OX=9606 GN=SH3RF2 PE=1 SV=3,0,28.364,11,4,61,4,729,79.3,9.94,31795,16.66,1,3,metabolic process;regulation of biological process,,catalytic activity;enzyme regulator activity;metal ion binding;protein binding,"Pf00018, Pf00097, Pf07653, Pf13445, Pf13639, Pf13920, Pf13923, Pf14570, Pf14604, Pf14634, Pf15227",153769,ENSG00000156463.17,SH3RF2,5,,,,0,High,1
Q9BQI0,Allograft inflammatory factor 1-like OS=Homo sapiens OX=9606 GN=AIF1L PE=1 SV=1,0,28.36,28,4,43,4,150,17.1,7.2,20056,,4,,,cytoplasm;cytoskeleton;membrane,metal ion binding;protein binding,Pf13499,83543,ENSG00000126878.12,AIF1L,9,,,,0,High,1
P24557,Thromboxane-A synthase OS=Homo sapiens OX=9606 GN=TBXAS1 PE=1 SV=3,0,28.359,19,7,18,7,533,60.5,7.62,6882,,7,,metabolic process,endoplasmic reticulum;membrane,catalytic activity;metal ion binding,Pf00067,6916,,TBXAS1,7,Metabolic pathways; Platelet activation; Arachidonic acid metabolism,Eicosanoid Synthesis; Prostaglandin Synthesis and Regulation,Eicosanoids; Synthesis of Prostaglandins (PG) and Thromboxanes (TX); Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD),18,High,1
Q86VI3,Ras GTPase-activating-like protein IQGAP3 OS=Homo sapiens OX=9606 GN=IQGAP3 PE=1 SV=2,0,28.33,3,5,54,1,1631,184.6,7.65,22496,,5,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,protein binding,"Pf00307, Pf00612, Pf00616, Pf03836",128239,ENSG00000183856.10,IQGAP3,1,Regulation of actin cytoskeleton,,RHO GTPases activate IQGAPs,5,High,1
P15814,Immunoglobulin lambda-like polypeptide 1 OS=Homo sapiens OX=9606 GN=IGLL1 PE=1 SV=1,0,28.326,23,4,64,3,213,22.9,10.07,30264,,4,,cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,protein binding,"Pf07654, Pf13927",3543,ENSG00000128322.6,IGLL1,22,Primary immunodeficiency,,Cell surface interactions at the vascular wall,3,High,1
P43003,Excitatory amino acid transporter 1 OS=Homo sapiens OX=9606 GN=SLC1A3 PE=1 SV=1,0,28.325,13,4,27,4,542,59.5,8.41,15106,,4,,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;membrane,metal ion binding;transporter activity,Pf00375,6507,ENSG00000079215.13,SLC1A3,5,Glutamatergic synapse,Synaptic Vesicle Pathway; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,Defective SLC1A3 causes episodic ataxia 6 (EA6); Glutamate Neurotransmitter Release Cycle; Astrocytic Glutamate-Glutamine Uptake And Metabolism; Transport of inorganic cations/anions and amino acids/oligopeptides,16,High,1
Q8WWN8,"Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ARAP3 PE=1 SV=1",0,28.321,5,6,19,6,1544,169.7,7.08,8541,,6,,cell differentiation;cell division;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endosome;membrane,catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding,"Pf00169, Pf00536, Pf00620, Pf00788, Pf01412, Pf07647, Pf15406, Pf15409",64411,ENSG00000120318.15,ARAP3,5,cAMP signaling pathway; Endocytosis; Rap1 signaling pathway,,Rho GTPase cycle,6,High,1
Q8WY91,THAP domain-containing protein 4 OS=Homo sapiens OX=9606 GN=THAP4 PE=1 SV=2,0,28.31,6,2,26,2,577,62.9,9.28,6950,10.88,2,1,,,DNA binding;metal ion binding;protein binding,"Pf05485, Pf08768",51078,ENSG00000176946.11,THAP4,2,,,,0,High,1
Q6UW02,Cytochrome P450 20A1 OS=Homo sapiens OX=9606 GN=CYP20A1 PE=1 SV=1,0,28.297,15,5,22,5,462,52.4,6.21,7695,,5,,metabolic process,membrane,catalytic activity;metal ion binding,Pf00067,57404,ENSG00000119004.15,CYP20A1,2,,Oxidation by Cytochrome P450; Metapathway biotransformation,,2,High,1
O15120,1-acyl-sn-glycerol-3-phosphate acyltransferase beta OS=Homo sapiens OX=9606 GN=AGPAT2 PE=1 SV=1,0,28.271,22,7,25,7,278,30.9,9.01,10866,,7,,metabolic process;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;membrane,catalytic activity,Pf01553,10555,ENSG00000169692.12,AGPAT2,9,Glycerophospholipid metabolism; Fat digestion and absorption; Metabolic pathways; Phospholipase D signaling pathway; Glycerolipid metabolism,Adipogenesis; Triacylglyceride Synthesis,Synthesis of PA; Neutrophil degranulation,15,High,1
P17096,High mobility group protein HMG-I/HMG-Y OS=Homo sapiens OX=9606 GN=HMGA1 PE=1 SV=3,0,28.269,23,3,59,2,107,11.7,10.32,21925,2.12,3,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,chromosome;cytosol;nucleus,catalytic activity;DNA binding;protein binding,,3159,ENSG00000137309.19,HMGA1,6,,Adipogenesis; Preimplantation Embryo; Senescence and Autophagy in Cancer,2-LTR circle formation; APOBEC3G mediated resistance to HIV-1 infection; Integration of viral DNA into host genomic DNA; Vpr-mediated nuclear import of PICs; Autointegration results in viral DNA circles; Formation of Senescence-Associated Heterochromatin Foci (SAHF),21,High,1
Q96P48,"Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ARAP1 PE=1 SV=3",0,28.259,6,7,25,7,1450,162.1,6.23,10086,,7,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytosol;Golgi;membrane,enzyme regulator activity;metal ion binding;protein binding,"Pf00169, Pf00536, Pf00620, Pf00788, Pf01412, Pf07647",116985,ENSG00000186635.14,ARAP1,11,Endocytosis,,PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; Rho GTPase cycle,7,High,1
P40261,Nicotinamide N-methyltransferase OS=Homo sapiens OX=9606 GN=NNMT PE=1 SV=1,0,28.239,20,5,32,5,264,29.6,5.74,11227,,5,,metabolic process;response to stimulus,cytoplasm;cytosol,catalytic activity,"Pf01234, Pf08241",4837,ENSG00000166741.7,NNMT,11,Metabolic pathways; Nicotinate and nicotinamide metabolism,Metapathway biotransformation; Methylation Pathways,"Metabolism of ingested SeMet, Sec, MeSec into H2Se; Methylation; Nicotinamide salvaging",15,High,1
O14972,Vacuolar protein sorting-associated protein 26C OS=Homo sapiens OX=9606 GN=VPS26C PE=1 SV=1,0,28.234,20,4,40,4,297,33,7.68,16987,,4,,transport,endosome;nucleus,transporter activity,"Pf00339, Pf03643",10311,ENSG00000157538.13,DSCR3,21,,,,0,High,1
Q6Y7W6,GRB10-interacting GYF protein 2 OS=Homo sapiens OX=9606 GN=GIGYF2 PE=1 SV=1,0,28.233,8,6,16,6,1299,150,5.54,6567,,6,,cell differentiation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;endosome;Golgi;membrane,protein binding;RNA binding,Pf02213,26058,ENSG00000204120.14,GIGYF2,2,,,,0,High,1
O94966-5,Isoform 5 of Ubiquitin carboxyl-terminal hydrolase 19 OS=Homo sapiens OX=9606 GN=USP19,0,28.229,8,7,33,6,1419,155.9,6.38,10475,5.96,6,1,metabolic process;regulation of biological process;response to stimulus,cytosol;membrane;nucleus,catalytic activity;metal ion binding;protein binding,"Pf00443, Pf01753, Pf04969, Pf13423, Pf14533",10869,ENSG00000172046.18,USP19,3,,,,0,High,1
Q9ULD2,Microtubule-associated tumor suppressor 1 OS=Homo sapiens OX=9606 GN=MTUS1 PE=1 SV=2,0,28.204,6,6,35,6,1270,141.3,7.5,11246,,6,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;Golgi;membrane;mitochondrion;nucleus,catalytic activity;motor activity;protein binding;structural molecule activity,"Pf00038, Pf01576, Pf02463, Pf03357, Pf04111, Pf04156, Pf04849, Pf05010, Pf05483, Pf05557, Pf05565, Pf05622, Pf06160, Pf06818, Pf07407, Pf07888, Pf07926, Pf08317, Pf09728, Pf09731, Pf09738, Pf09744, Pf10174, Pf10186, Pf12128, Pf12474, Pf12718, Pf13166, Pf13514, Pf13851, Pf13868, Pf14915, Pf15294, Pf15397",57509,ENSG00000129422.14,MTUS1,8,,,,0,High,1
O75365,Protein tyrosine phosphatase type IVA 3 OS=Homo sapiens OX=9606 GN=PTP4A3 PE=1 SV=2,0,28.197,36,5,19,5,173,19.5,9.22,6034,8.94,4,1,cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;endosome;membrane;nucleus,catalytic activity;protein binding,"Pf00102, Pf00782",11156,ENSG00000275575.4; ENSG00000184489.11,PTP4A3,8; CHR_HSCHR8_5_CTG7,,,,0,High,1
Q9H6N6,Putative uncharacterized protein MYH16 OS=Homo sapiens OX=9606 GN=MYH16 PE=1 SV=2,0,28.188,4,5,760,1,1097,128.2,5.49,424455,0,4,2,cell organization and biogenesis;metabolic process,,catalytic activity;motor activity,"Pf01576, Pf04111, Pf04582, Pf05483, Pf09726",84176,,MYH16,7,,,,0,High,1
P41247,Patatin-like phospholipase domain-containing protein 4 OS=Homo sapiens OX=9606 GN=PNPLA4 PE=2 SV=3,0,28.14,30,5,28,5,253,28,9.11,10484,,5,,metabolic process,cytosol;membrane;mitochondrion,catalytic activity,Pf01734,8228,ENSG00000006757.11,PNPLA4,X,Retinol metabolism,,Triglyceride catabolism,5,High,1
Q32P44,Echinoderm microtubule-associated protein-like 3 OS=Homo sapiens OX=9606 GN=EML3 PE=1 SV=1,0,28.126,10,6,12,6,896,95.1,7.12,4944,,6,,,cytoplasm;cytoskeleton,protein binding,"Pf00400, Pf03451",256364,ENSG00000149499.11,EML3,11,,,,0,High,1
Q9Y6G5,COMM domain-containing protein 10 OS=Homo sapiens OX=9606 GN=COMMD10 PE=1 SV=1,0,28.12,33,6,25,6,202,23,6.54,12087,,6,,metabolic process;regulation of biological process,cytoplasm;nucleus,protein binding,Pf07258,51397,ENSG00000145781.8,COMMD10,5,,,Neddylation,3,High,1
Q59H18-1,Isoform 1 of Serine/threonine-protein kinase TNNI3K OS=Homo sapiens OX=9606 GN=TNNI3K,0,28.085,10,6,18,5,936,104.1,6.81,606,31.92,1,5,cell communication;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,"Pf00023, Pf00069, Pf07714, Pf12796, Pf13606, Pf13637, Pf13857",100526835; 51086; 8790,,FPGT-TNNI3K; TNNI3K; FPGT,1,,,,0,High,1
Q96SW2,Protein cereblon OS=Homo sapiens OX=9606 GN=CRBN PE=1 SV=1,0,28.063,17,5,16,5,442,50.5,5.63,8186,,5,,metabolic process;regulation of biological process,cytoplasm;membrane;nucleus,catalytic activity;metal ion binding;protein binding,Pf02190,51185,ENSG00000113851.14,CRBN,3,,,,0,High,1
Q86YB8,ERO1-like protein beta OS=Homo sapiens OX=9606 GN=ERO1B PE=1 SV=2,0,28.03,14,6,33,4,467,53.5,7.99,14330,,6,,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;transport,endoplasmic reticulum;membrane,catalytic activity;protein binding,Pf04137,56605,ENSG00000086619.13,ERO1LB; ERO1B,1,Protein processing in endoplasmic reticulum,,Insulin processing,4,High,1
P81605,Dermcidin OS=Homo sapiens OX=9606 GN=DCD PE=1 SV=2,0,28.001,35,4,36,4,110,11.3,6.54,20534,,4,,defense response;metabolic process;response to stimulus,extracellular,catalytic activity;protein binding;RNA binding,Pf15291,117159,ENSG00000161634.11,DCD,12,,,Antimicrobial peptides,3,High,1
P21291,Cysteine and glycine-rich protein 1 OS=Homo sapiens OX=9606 GN=CSRP1 PE=1 SV=3,0,27.992,21,4,87,4,193,20.6,8.57,45354,,4,,,nucleus,metal ion binding;RNA binding,Pf00412,1465,ENSG00000159176.13,CSRP1,1,,Mecp2 and Associated Rett Syndrome,MTF1 activates gene expression,4,High,1
Q9BRA2,Thioredoxin domain-containing protein 17 OS=Homo sapiens OX=9606 GN=TXNDC17 PE=1 SV=1,0,27.963,27,3,144,3,123,13.9,5.52,67865,,3,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,antioxidant activity;catalytic activity;protein binding,"Pf06110, Pf13098",84817,ENSG00000129235.10,TXNDC17,17,,,,0,High,1
A0A0A0MS15,Immunoglobulin heavy variable 3-49 OS=Homo sapiens OX=9606 GN=IGHV3-49 PE=3 SV=1,0,27.961,27,4,34,4,119,13,8.62,16022,0,4,1,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,protein binding,,28423,ENSG00000211965.4; ENSG00000275316.3,IGHV3-49,14; CHR_HSCHR14_3_CTG1,,,,0,High,1
Q96JH7,Deubiquitinating protein VCIP135 OS=Homo sapiens OX=9606 GN=VCPIP1 PE=1 SV=2,0,27.912,8,7,23,7,1222,134.2,7.2,7740,,7,,cell organization and biogenesis;metabolic process,cytoplasm;endoplasmic reticulum;Golgi;organelle lumen,catalytic activity,Pf02338,80124,ENSG00000175073.7,VCPIP1,8,,,Ovarian tumor domain proteases,4,High,1
Q9Y3S1,Serine/threonine-protein kinase WNK2 OS=Homo sapiens OX=9606 GN=WNK2 PE=1 SV=4,0,27.895,2,6,28,4,2297,242.5,6.13,13133,0,6,1,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;nucleotide binding,"Pf00069, Pf07714, Pf12202",65268,ENSG00000165238.16,WNK2,9,,,Stimuli-sensing channels,3,High,1
Q9BV86,N-terminal Xaa-Pro-Lys N-methyltransferase 1 OS=Homo sapiens OX=9606 GN=NTMT1 PE=1 SV=3,0,27.881,32,6,50,6,223,25.4,5.52,17654,7.64,5,1,cell organization and biogenesis;metabolic process,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,"Pf00891, Pf01209, Pf05891, Pf08241, Pf08242, Pf12847, Pf13489, Pf13649, Pf13847",28989,ENSG00000148335.14,NTMT1,9,,,,0,High,1
Q96IZ0,PRKC apoptosis WT1 regulator protein OS=Homo sapiens OX=9606 GN=PAWR PE=1 SV=1,0,27.861,32,5,27,5,340,36.5,5.41,5305,,5,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;membrane;nucleus,protein binding;transporter activity,"Pf01544, Pf05911, Pf08614",5074,ENSG00000177425.10,PAWR,12,,,,0,High,1
Q5R372-5,Isoform 5 of Rab GTPase-activating protein 1-like OS=Homo sapiens OX=9606 GN=RABGAP1L,0,27.836,12,4,38,1,378,43.9,6.57,19938,,4,,regulation of biological process;transport,endosome;Golgi;nucleus,enzyme regulator activity;protein binding,"Pf00566, Pf03148",9910,ENSG00000152061.23,RABGAP1L,1,,,,0,High,1
Q5BJH7,Protein YIF1B OS=Homo sapiens OX=9606 GN=YIF1B PE=1 SV=1,0,27.828,29,4,21,4,314,34.4,9.16,8006,,4,,transport,membrane,,Pf03878,90522,ENSG00000167645.16,YIF1B,19,,,,0,High,1
P14317,Hematopoietic lineage cell-specific protein OS=Homo sapiens OX=9606 GN=HCLS1 PE=1 SV=3,0,27.811,12,4,16,4,486,54,4.81,6968,,4,,cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;mitochondrion;nucleus,protein binding,"Pf00018, Pf02218, Pf07653, Pf14604",3059,ENSG00000180353.10,HCLS1,3,Pathogenic Escherichia coli infection; Proteoglycans in cancer; Bacterial invasion of epithelial cells; Shigellosis; Tight junction,Pathogenic Escherichia coli infection; B Cell Receptor Signaling Pathway; TYROBP Causal Network,,8,High,1
Q2TB90,Hexokinase HKDC1 OS=Homo sapiens OX=9606 GN=HKDC1 PE=1 SV=3,0,27.767,3,4,209,1,917,102.5,7.12,109280,,4,,cellular homeostasis;metabolic process,cytosol;mitochondrion,catalytic activity;nucleotide binding,"Pf00349, Pf03727",80201,ENSG00000156510.12,HKDC1,10,"Central carbon metabolism in cancer; Starch and sucrose metabolism; Metabolic pathways; Carbon metabolism; Fructose and mannose metabolism; Galactose metabolism; Glycolysis / Gluconeogenesis; Insulin signaling pathway; Type II diabetes mellitus; Carbohydrate digestion and absorption; HIF-1 signaling pathway; Neomycin, kanamycin and gentamicin biosynthesis; Amino sugar and nucleotide sugar metabolism",,,13,High,1
Q9BUE6,"Iron-sulfur cluster assembly 1 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=ISCA1 PE=1 SV=1",0,27.755,42,4,35,4,129,14.2,9.07,15910,,4,,cell organization and biogenesis;metabolic process,mitochondrion;organelle lumen,metal ion binding;structural molecule activity,Pf01521,81689,ENSG00000135070.14,ISCA1,9,,,Mitochondrial iron-sulfur cluster biogenesis,2,High,1
P49441,Inositol polyphosphate 1-phosphatase OS=Homo sapiens OX=9606 GN=INPP1 PE=1 SV=1,0,27.733,19,4,17,4,399,44,5.26,9282,,4,,metabolic process;regulation of biological process;response to stimulus,cytosol,catalytic activity;metal ion binding,Pf00459,3628,ENSG00000151689.12,INPP1,2,Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system,,"Synthesis of IP2, IP, and Ins in the cytosol",6,High,1
O43426,Synaptojanin-1 OS=Homo sapiens OX=9606 GN=SYNJ1 PE=1 SV=2,0,27.696,4,5,37,5,1573,173,7.42,12986,,5,,cell organization and biogenesis;metabolic process;response to stimulus;transport,cytoplasm;cytosol;membrane,catalytic activity;RNA binding,"Pf02383, Pf03372, Pf08952",8867,,SYNJ1,21,Phosphatidylinositol signaling system; Inositol phosphate metabolism; Metabolic pathways,EGF/EGFR Signaling Pathway,"Synthesis of PIPs at the plasma membrane; Synthesis of IP3 and IP4 in the cytosol; Clathrin-mediated endocytosis; Synthesis of IP2, IP, and Ins in the cytosol",15,High,1
Q8ND76,Cyclin-Y OS=Homo sapiens OX=9606 GN=CCNY PE=1 SV=2,0,27.651,16,5,47,3,341,39.3,7.2,18657,,5,,cell division;regulation of biological process;response to stimulus,membrane;nucleus,enzyme regulator activity;protein binding,Pf00134,219771,ENSG00000108100.17,CCNY,10,,,,0,High,1
P23469,Receptor-type tyrosine-protein phosphatase epsilon OS=Homo sapiens OX=9606 GN=PTPRE PE=1 SV=1,0,27.622,13,8,27,6,700,80.6,7.02,10075,,8,,metabolic process;regulation of biological process,cytoplasm;membrane;nucleus,catalytic activity;protein binding;receptor activity;signal transducer activity,"Pf00102, Pf00782, Pf14566",5791,ENSG00000132334.16,PTPRE,10,,,,0,High,1
Q13485,Mothers against decapentaplegic homolog 4 OS=Homo sapiens OX=9606 GN=SMAD4 PE=1 SV=1,0,27.606,13,6,23,6,552,60.4,6.99,8541,,6,,cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,DNA binding;metal ion binding;protein binding;signal transducer activity,"Pf03165, Pf03166, Pf05539",4089,ENSG00000141646.13,SMAD4,18,Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Pancreatic cancer; Wnt signaling pathway; Pathways in cancer; Chronic myeloid leukemia; Cell cycle; Hepatitis B; HTLV-I infection; Colorectal cancer; FoxO signaling pathway; TGF-beta signaling pathway; Adherens junction; AGE-RAGE signaling pathway in diabetic complications,Androgen receptor signaling pathway; Bone Morphogenic Protein (BMP) Signalling and Regulation; Heart Development; Cell Cycle; Endoderm Differentiation; Mesodermal Commitment Pathway; Ectoderm Differentiation; Extracellular vesicle-mediated signaling in recipient cells; Hepatitis C and Hepatocellular Carcinoma; Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex; TGF-beta Signaling Pathway; Hypothesized Pathways in Pathogenesis of Cardiovascular Disease; TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition; Canonical and Non-Canonical TGF-B signaling; BMP Signaling Pathway in Eyelid Development; ESC Pluripotency Pathways; TGF-beta Receptor Signaling; Senescence and Autophagy in Cancer; DNA Damage Response (only ATM dependent),Signaling by NODAL; RUNX3 regulates BCL2L11 (BIM) transcription; Transcriptional regulation of pluripotent stem cells; Ub-specific processing proteases; RUNX2 regulates bone development; TGF-beta receptor signaling activates SMADs; SMAD4 MH2 Domain Mutants in Cancer; Signaling by BMP; Signaling by Activin; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; RUNX3 regulates CDKN1A transcription,64,High,1
Q8IY21,Probable ATP-dependent RNA helicase DDX60 OS=Homo sapiens OX=9606 GN=DDX60 PE=1 SV=3,0,27.601,5,9,57,6,1712,197.7,7.59,15476,,9,,defense response;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol,catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding,"Pf00270, Pf00271, Pf04851",55601,ENSG00000137628.16,DDX60,4,,,,0,High,1
Q8IVN3,Musculoskeletal embryonic nuclear protein 1 OS=Homo sapiens OX=9606 GN=MUSTN1 PE=3 SV=2,0,27.586,29,3,27,3,82,8.9,9.86,15745,8.09,2,1,cell differentiation;cell proliferation,nucleus,,,389125,ENSG00000272573.5,MUSTN1,3,,,,0,High,1
Q15629,Translocating chain-associated membrane protein 1 OS=Homo sapiens OX=9606 GN=TRAM1 PE=1 SV=3,0,27.57,17,5,10,5,374,43,9.63,4889,,5,,cell organization and biogenesis;transport,endoplasmic reticulum;membrane,protein binding;receptor activity,"Pf03798, Pf08390",23471,ENSG00000067167.7,TRAM1,8,Protein processing in endoplasmic reticulum,TLR4 Signaling and Tolerance,SRP-dependent cotranslational protein targeting to membrane,5,High,1
Q13188,Serine/threonine-protein kinase 3 OS=Homo sapiens OX=9606 GN=STK3 PE=1 SV=2,0,27.562,20,8,23,4,491,56.3,5.24,7909,0,8,2,cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf00956, Pf07714, Pf11629",6788,ENSG00000104375.15,STK3,8,MAPK signaling pathway; Hippo signaling pathway -multiple species; Hippo signaling pathway,MAPK Signaling Pathway,Signaling by Hippo,6,High,1
Q92520,Protein FAM3C OS=Homo sapiens OX=9606 GN=FAM3C PE=1 SV=1,0,27.547,22,4,64,4,227,24.7,8.29,24532,0,4,2,cell differentiation;cell organization and biogenesis;cell proliferation;development;regulation of biological process;response to stimulus;transport,cytoplasm;extracellular;organelle lumen,protein binding,,10447; 51384,ENSG00000196937.10,FAM3C; WNT16,7,,Wnt Signaling Pathway and Pluripotency; Wnt Signaling Pathway; DNA Damage Response (only ATM dependent),Platelet degranulation,7,High,1
Q6IA69,Glutamine-dependent NAD(+) synthetase OS=Homo sapiens OX=9606 GN=NADSYN1 PE=1 SV=3,0,27.535,8,6,34,5,706,79.2,6.44,15387,,6,,metabolic process,cytoplasm;cytosol,catalytic activity;nucleotide binding;protein binding,"Pf00795, Pf02540",55191,ENSG00000172890.11,NADSYN1,11,Metabolic pathways; Nicotinate and nicotinamide metabolism,NAD Biosynthesis II (from tryptophan); NAD+ biosynthetic pathways,Nicotinate metabolism,8,High,1
Q06136,3-ketodihydrosphingosine reductase OS=Homo sapiens OX=9606 GN=KDSR PE=1 SV=1,0,27.527,28,6,30,6,332,36.2,7.12,11516,,6,,metabolic process,endoplasmic reticulum;membrane,catalytic activity,"Pf00106, Pf01370, Pf08659, Pf13561",2531,ENSG00000119537.15,KDSR,18,Sphingolipid metabolism; Metabolic pathways,Sphingolipid Metabolism,Sphingolipid de novo biosynthesis,7,High,1
Q9NWS8,Required for meiotic nuclear division protein 1 homolog OS=Homo sapiens OX=9606 GN=RMND1 PE=1 SV=2,0,27.509,10,4,24,4,449,51.6,8.69,10721,,4,,metabolic process;regulation of biological process,mitochondrion,protein binding,Pf02582,55005,ENSG00000155906.16,RMND1,6,,,,0,High,1
Q8TEX9,Importin-4 OS=Homo sapiens OX=9606 GN=IPO4 PE=1 SV=2,0,27.507,7,6,27,6,1081,118.6,4.96,10077,,6,,cell organization and biogenesis;transport,cytoplasm;membrane;nucleus,protein binding;transporter activity,"Pf01602, Pf13513, Pf13646",79711,ENSG00000196497.16,IPO4,14,,,,0,High,1
P35268,60S ribosomal protein L22 OS=Homo sapiens OX=9606 GN=RPL22 PE=1 SV=2,0,27.478,57,5,66,4,128,14.8,9.19,31363,0,4,1,cell organization and biogenesis;metabolic process;transport,cytoplasm;cytosol;nucleus;ribosome,protein binding;RNA binding;structural molecule activity,Pf01776,6146,ENSG00000116251.9,RPL22,1,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
Q9NZC3,Glycerophosphodiester phosphodiesterase 1 OS=Homo sapiens OX=9606 GN=GDE1 PE=1 SV=1,0,27.459,22,5,27,5,331,37.7,6.71,10310,,5,,metabolic process,membrane,catalytic activity;metal ion binding,Pf03009,51573,ENSG00000006007.11,GDE1,16,,,Glycerophospholipid catabolism,5,High,1
Q9P0P8,Mitochondrial transcription rescue factor 1 OS=Homo sapiens OX=9606 GN=MTRES1 PE=1 SV=1,0,27.449,12,3,39,3,240,27.9,9.29,16088,,3,,,mitochondrion,,,51250,ENSG00000130349.9,C6orf203,6,,,,0,High,1
Q8IWB9,Testis-expressed protein 2 OS=Homo sapiens OX=9606 GN=TEX2 PE=1 SV=2,0,27.399,6,6,22,6,1127,125.2,6.01,9506,,6,,metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;membrane,,Pf10296,55852,ENSG00000136478.7,TEX2,17,,,,0,High,1
Q9BTE3,Mini-chromosome maintenance complex-binding protein OS=Homo sapiens OX=9606 GN=MCMBP PE=1 SV=2,0,27.378,8,4,19,4,642,72.9,5.87,8372,0,4,1,cell division;cell organization and biogenesis;metabolic process,cytosol;membrane;nucleus,protein binding,"Pf09739, Pf13615",79892,ENSG00000197771.12,MCMBP,10,,,,0,High,1
O75391,Sperm-associated antigen 7 OS=Homo sapiens OX=9606 GN=SPAG7 PE=1 SV=2,0,27.378,19,5,18,5,227,26,7.91,8763,,5,,,nucleus,,Pf01424,9552,ENSG00000091640.7,SPAG7,17,,,,0,High,1
O15068,Guanine nucleotide exchange factor DBS OS=Homo sapiens OX=9606 GN=MCF2L PE=1 SV=2,0,27.369,7,5,22,5,1137,128,6.43,8866,0,4,1,regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,protein binding,"Pf00018, Pf00169, Pf00435, Pf00621, Pf07653, Pf13716, Pf14604",23263,ENSG00000126217.20,MCF2L,13,,,G alpha (12/13) signalling events; NRAGE signals death through JNK; Signalling by NGF; Rho GTPase cycle,11,High,1
Q9BTT0,Acidic leucine-rich nuclear phosphoprotein 32 family member E OS=Homo sapiens OX=9606 GN=ANP32E PE=1 SV=1,0,27.356,18,3,27,3,268,30.7,3.85,12720,,3,,cell organization and biogenesis;regulation of biological process;transport,cytoplasm;nucleus,enzyme regulator activity;protein binding,"Pf12799, Pf13855, Pf14580",81611,ENSG00000143401.14,ANP32E,1,,,,0,High,1
Q7Z3U7,Protein MON2 homolog OS=Homo sapiens OX=9606 GN=MON2 PE=1 SV=3,0,27.353,3,5,29,5,1717,190.2,6.06,13572,,5,,transport,cytosol,protein binding,"Pf09324, Pf12783",23041,ENSG00000061987.14,MON2,12,,,,0,High,1
Q8NCE2,Myotubularin-related protein 14 OS=Homo sapiens OX=9606 GN=MTMR14 PE=1 SV=2,0,27.327,10,3,11,3,650,72.2,6.24,4798,,3,,cell communication;metabolic process;response to stimulus,cytoplasm;cytosol,catalytic activity;protein binding;receptor activity;signal transducer activity,,64419,ENSG00000163719.19,MTMR14,3,Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system,,Synthesis of PIPs at the plasma membrane; Macroautophagy,10,High,1
Q8NEZ5,F-box only protein 22 OS=Homo sapiens OX=9606 GN=FBXO22 PE=1 SV=1,0,27.324,19,6,24,6,403,44.5,7.03,9337,,6,,cell communication;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,"Pf00646, Pf10442, Pf12937",26263,ENSG00000167196.13,FBXO22,15,,,Antigen processing: Ubiquitination & Proteasome degradation; Neddylation,7,High,1
O60220,Mitochondrial import inner membrane translocase subunit Tim8 A OS=Homo sapiens OX=9606 GN=TIMM8A PE=1 SV=1,0,27.318,53,3,32,3,97,11,5.16,13273,,3,,transport,membrane;mitochondrion,metal ion binding;protein binding,Pf02953,1678,ENSG00000126953.5,TIMM8A,X,,,Mitochondrial protein import; Metabolism of proteins,2,High,1
Q9P258,Protein RCC2 OS=Homo sapiens OX=9606 GN=RCC2 PE=1 SV=2,0,27.318,13,6,24,6,522,56,8.78,10561,,6,,cell division;cell organization and biogenesis;regulation of biological process;response to stimulus,chromosome;cytoplasm;cytoskeleton;cytosol;membrane;nucleus,protein binding;RNA binding,"Pf00415, Pf13540",55920,ENSG00000281540.2; ENSG00000179051.13,RCC2,1; CHR_HG2095_PATCH,,,Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins,16,High,1
Q06481,Amyloid-like protein 2 OS=Homo sapiens OX=9606 GN=APLP2 PE=1 SV=2,0,27.312,9,6,30,5,763,86.9,4.79,10265,,6,,metabolic process;regulation of biological process;response to stimulus;transport,membrane;nucleus;organelle lumen,DNA binding;enzyme regulator activity;metal ion binding;protein binding,"Pf00014, Pf02177, Pf03938, Pf10515, Pf12924, Pf12925",334,ENSG00000084234.16,APLP2,11,,,Platelet degranulation ; Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs),8,High,1
P32456,Guanylate-binding protein 2 OS=Homo sapiens OX=9606 GN=GBP2 PE=1 SV=3,0,27.31,10,5,20,4,591,67.2,5.71,11409,,5,,regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;Golgi;membrane,catalytic activity;nucleotide binding;protein binding,"Pf02263, Pf02841, Pf05879",2634,ENSG00000162645.12,GBP2,1,NOD-like receptor signaling pathway,,Interferon alpha/beta signaling; Interferon gamma signaling,6,High,1
Q9BZK7,F-box-like/WD repeat-containing protein TBL1XR1 OS=Homo sapiens OX=9606 GN=TBL1XR1 PE=1 SV=1,0,27.309,16,5,15,5,514,55.6,5.55,5945,,5,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,nucleus,DNA binding;protein binding,"Pf00400, Pf08513, Pf08662",79718,ENSG00000177565.16,TBL1XR1,3,Wnt signaling pathway,,"NOTCH1 Intracellular Domain Regulates Transcription; Transcriptional regulation of white adipocyte differentiation; Activation of gene expression by SREBF (SREBP); RORA activates gene expression; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; PPARA activates gene expression; YAP1- and WWTR1 (TAZ)-stimulated gene expression; Constitutive Signaling by NOTCH1 PEST Domain Mutants; HDACs deacetylate histones; Transcriptional activation of mitochondrial biogenesis; BMAL1:CLOCK,NPAS2 activates circadian gene expression; RUNX3 regulates YAP1-mediated transcription",36,High,1
Q9HC21,Mitochondrial thiamine pyrophosphate carrier OS=Homo sapiens OX=9606 GN=SLC25A19 PE=1 SV=1,0,27.263,19,6,24,6,320,35.5,9.55,10668,,6,,metabolic process;transport,membrane;mitochondrion;nucleus,transporter activity,Pf00153,60386,ENSG00000125454.11,SLC25A19,17,,,Vitamin B1 (thiamin) metabolism,4,High,1
Q9UJY5,ADP-ribosylation factor-binding protein GGA1 OS=Homo sapiens OX=9606 GN=GGA1 PE=1 SV=1,0,27.263,14,5,21,5,639,70.3,5.29,6171,0,5,1,metabolic process;regulation of biological process;transport,endosome;Golgi;membrane,protein binding,"Pf00790, Pf02883, Pf03127",26088,ENSG00000100083.18,GGA1,22,Lysosome,,TBC/RABGAPs; Amyloid fiber formation,7,High,1
O14657,Torsin-1B OS=Homo sapiens OX=9606 GN=TOR1B PE=1 SV=2,0,27.251,18,5,22,5,336,38,8.54,10100,,5,,cell organization and biogenesis;metabolic process;response to stimulus,cytoplasm;endoplasmic reticulum;membrane;nucleus;organelle lumen,catalytic activity;nucleotide binding;protein binding,"Pf06309, Pf07724",27348,ENSG00000136816.15,TOR1B,9,,,Cargo recognition for clathrin-mediated endocytosis,4,High,1
Q9UGR2,Zinc finger CCCH domain-containing protein 7B OS=Homo sapiens OX=9606 GN=ZC3H7B PE=1 SV=2,0,27.244,8,7,22,7,977,109.8,7.25,9090,1.69,7,1,,,,,,,,,,,,0,High,1
Q10570,Cleavage and polyadenylation specificity factor subunit 1 OS=Homo sapiens OX=9606 GN=CPSF1 PE=1 SV=2,0,27.236,7,8,27,8,1443,160.8,6.4,9204,,8,,metabolic process;transport,nucleus,protein binding;RNA binding,"Pf03178, Pf10433",29894,ENSG00000071894.16,CPSF1,8,mRNA surveillance pathway,mRNA Processing,mRNA 3'-end processing; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA Splicing - Major Pathway; tRNA processing in the nucleus; Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs,18,High,1
Q96KR6,"Protein FAM210B, mitochondrial OS=Homo sapiens OX=9606 GN=FAM210B PE=1 SV=2",0,27.236,32,4,100,4,192,20.4,10.43,35596,13.08,3,1,cell differentiation;regulation of biological process;response to stimulus,membrane;mitochondrion,,Pf06916,116151,ENSG00000124098.9,FAM210B,20,,,,0,High,1
O75179,Ankyrin repeat domain-containing protein 17 OS=Homo sapiens OX=9606 GN=ANKRD17 PE=1 SV=3,0,27.228,4,7,17,3,2603,274.1,6.52,6806,,7,,defense response;regulation of biological process;response to stimulus,chromosome;cytoplasm;membrane;nucleus,protein binding;RNA binding,"Pf00013, Pf00023, Pf05109, Pf07223, Pf12796, Pf13014, Pf13606, Pf13637, Pf13857",26057,ENSG00000132466.18,ANKRD17,4,,,,0,High,1
Q9Y6I9,Testis-expressed protein 264 OS=Homo sapiens OX=9606 GN=TEX264 PE=1 SV=1,0,27.208,21,4,14,4,313,34.2,4.86,6738,,4,,transport,extracellular;organelle lumen,protein binding,Pf06445,51368,ENSG00000164081.12,TEX264,3,,,Platelet degranulation,4,High,1
Q9NWU2,Glucose-induced degradation protein 8 homolog OS=Homo sapiens OX=9606 GN=GID8 PE=1 SV=1,0,27.208,34,5,18,5,228,26.7,4.97,7250,,5,,,nucleus,protein binding,"Pf08513, Pf10607",54994,ENSG00000101193.7,GID8,20,,,,0,High,1
P67812,Signal peptidase complex catalytic subunit SEC11A OS=Homo sapiens OX=9606 GN=SEC11A PE=1 SV=1,0,27.208,20,5,39,5,179,20.6,9.48,19721,,5,,metabolic process,endoplasmic reticulum;membrane,catalytic activity,Pf00717,23478,ENSG00000140612.13,SEC11A,15,Protein export,,"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Synthesis, secretion, and deacylation of Ghrelin; SRP-dependent cotranslational protein targeting to membrane; Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)",9,High,1
Q9BZF1,Oxysterol-binding protein-related protein 8 OS=Homo sapiens OX=9606 GN=OSBPL8 PE=1 SV=3,0,27.197,11,7,26,7,889,101.1,6.96,11038,0,7,1,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytosol;endoplasmic reticulum;membrane;nucleus,transporter activity,"Pf00169, Pf01237",114882,ENSG00000091039.16,OSBPL8,12,,,Acyl chain remodelling of PS,5,High,1
Q9H0C8,Integrin-linked kinase-associated serine/threonine phosphatase 2C OS=Homo sapiens OX=9606 GN=ILKAP PE=1 SV=1,0,27.164,14,5,21,5,392,42.9,7.09,9583,0,5,1,metabolic process,cytoplasm,catalytic activity;metal ion binding;protein binding,Pf00481,80895,ENSG00000132323.8,ILKAP,2,,,,0,High,1
Q9H4B0,"Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=OSGEPL1 PE=2 SV=2",0,27.128,13,4,36,4,414,45.1,8.56,15350,,4,,metabolic process,mitochondrion,catalytic activity;metal ion binding,"Pf00814, Pf01869",64172,ENSG00000128694.11,OSGEPL1,2,,,,0,High,1
O95786,Probable ATP-dependent RNA helicase DDX58 OS=Homo sapiens OX=9606 GN=DDX58 PE=1 SV=2,0,27.121,10,8,24,8,925,106.5,6.4,8955,0,8,1,defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane,catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding,"Pf00270, Pf00271, Pf04851, Pf11648",23586,ENSG00000107201.9,DDX58,9,Measles; Hepatitis B; RIG-I-like receptor signaling pathway; NF-kappa B signaling pathway; Herpes simplex infection; Cytosolic DNA-sensing pathway; Epstein-Barr virus infection; Influenza A; Hepatitis C,RIG-I-like Receptor Signaling,ISG15 antiviral mechanism; Ub-specific processing proteases; Negative regulators of DDX58/IFIH1 signaling; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; TRAF6 mediated NF-kB activation; TRAF6 mediated IRF7 activation; Ovarian tumor domain proteases; TRAF3-dependent IRF activation pathway,27,High,1
P53384,Cytosolic Fe-S cluster assembly factor NUBP1 OS=Homo sapiens OX=9606 GN=NUBP1 PE=1 SV=2,0,27.112,17,3,46,3,320,34.5,5.33,18247,0,3,1,cell growth;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,metal ion binding;nucleotide binding;protein binding,"Pf01656, Pf02374, Pf09140, Pf10609, Pf13207, Pf13614",4682,ENSG00000103274.10,NUBP1,16,,,Cytosolic iron-sulfur cluster assembly,2,High,1
Q92692-2,Isoform Alpha of Nectin-2 OS=Homo sapiens OX=9606 GN=NECTIN2,0,27.087,15,5,18,5,479,51.3,5.11,7203,3.03,4,1,cell organization and biogenesis;regulation of biological process;response to stimulus,cell surface;membrane,protein binding;receptor activity;signal transducer activity,"Pf08205, Pf13927",5819,ENSG00000130202.9,PVRL2; NECTIN2,19,,Monoamine Transport,,1,High,1
Q86YR5,G-protein-signaling modulator 1 OS=Homo sapiens OX=9606 GN=GPSM1 PE=1 SV=2,0,27.056,9,3,22,3,675,74.5,6.54,9015,,3,,cell differentiation;development;regulation of biological process,cytoplasm;cytosol;endoplasmic reticulum;Golgi;membrane,enzyme regulator activity;protein binding,"Pf00515, Pf02188, Pf13176, Pf13181, Pf13414, Pf13424",26086,,GPSM1,9,Cocaine addiction,,G alpha (i) signalling events,5,High,1
Q9BW27,Nuclear pore complex protein Nup85 OS=Homo sapiens OX=9606 GN=NUP85 PE=1 SV=1,0,27.041,10,5,12,5,656,75,5.55,5601,,5,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,chromosome;cytoplasm;cytoskeleton;cytosol;membrane;nucleus,protein binding;structural molecule activity,Pf07575,79902,ENSG00000125450.10,NUP85,17,RNA transport,Integrated Breast Cancer Pathway,Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; Separation of Sister Chromatids; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Resolution of Sister Chromatid Cohesion; Transport of Ribonucleoproteins into the Host Nucleus; RHO GTPases Activate Formins; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins,78,High,1
Q9Y3C8,Ubiquitin-fold modifier-conjugating enzyme 1 OS=Homo sapiens OX=9606 GN=UFC1 PE=1 SV=3,0,26.977,21,5,59,5,167,19.4,7.4,24322,0,5,2,metabolic process;response to stimulus,cytoplasm,catalytic activity;protein binding,Pf08694,51506,ENSG00000143222.11,UFC1,1,,,,0,High,1
A0A0A0MRZ8,Immunoglobulin kappa variable 3D-11 OS=Homo sapiens OX=9606 GN=IGKV3D-11 PE=3 SV=6,0,26.969,37,3,52,2,115,12.6,5.29,23329,,3,,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity,"Pf00047, Pf07679, Pf07686",28876,ENSG00000211632.4,IGKV3D-11,2,,,,0,High,1
P51636,Caveolin-2 OS=Homo sapiens OX=9606 GN=CAV2 PE=1 SV=2,0,26.958,27,2,30,2,162,18.3,5.27,10625,,2,,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;Golgi;membrane;nucleus,protein binding;structural molecule activity,Pf01146,858,ENSG00000105971.14,CAV2,7,Endocytosis; Focal adhesion; Bacterial invasion of epithelial cells; Proteoglycans in cancer,Integrin-mediated Cell Adhesion; Focal Adhesion; EGF/EGFR Signaling Pathway,,7,High,1
Q3SY69,Mitochondrial 10-formyltetrahydrofolate dehydrogenase OS=Homo sapiens OX=9606 GN=ALDH1L2 PE=1 SV=2,0,26.951,5,5,51,2,923,101.7,6.52,30311,,5,,metabolic process,cytoplasm;mitochondrion;organelle lumen,catalytic activity,"Pf00171, Pf00550, Pf00551, Pf02911",160428,ENSG00000136010.13,ALDH1L2,12,One carbon pool by folate,,Metabolism of folate and pterines,5,High,1
Q14746,Conserved oligomeric Golgi complex subunit 2 OS=Homo sapiens OX=9606 GN=COG2 PE=1 SV=1,0,26.943,13,6,17,6,738,83.2,6.62,5755,,6,,cell organization and biogenesis;transport,cytosol;Golgi;membrane,protein binding;transporter activity,"Pf06148, Pf12022",22796,ENSG00000135775.13,COG2,1,,,COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network,11,High,1
P15153,Ras-related C3 botulinum toxin substrate 2 OS=Homo sapiens OX=9606 GN=RAC2 PE=1 SV=1,0,26.917,21,4,36,2,192,21.4,7.61,18715,,4,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf08477",5880,ENSG00000128340.14,RAC2,22,VEGF signaling pathway; Regulation of actin cytoskeleton; Focal adhesion; Axon guidance; Natural killer cell mediated cytotoxicity; Ras signaling pathway; Rap1 signaling pathway; Sphingolipid signaling pathway; Pancreatic cancer; Adherens junction; Wnt signaling pathway; Chemokine signaling pathway; Colorectal cancer; Viral myocarditis; Leukocyte transendothelial migration; Choline metabolism in cancer; Pathways in cancer; MAPK signaling pathway; B cell receptor signaling pathway; cAMP signaling pathway; Fc gamma R-mediated phagocytosis; Fc epsilon RI signaling pathway,Integrin-mediated Cell Adhesion; RalA downstream regulated genes; B Cell Receptor Signaling Pathway; Focal Adhesion; MAPK Signaling Pathway; Chemokine signaling pathway; Microglia Pathogen Phagocytosis Pathway; Insulin Signaling; Regulation of Actin Cytoskeleton; DNA Damage Response (only ATM dependent),G alpha (12/13) signalling events; GPVI-mediated activation cascade; Sema4D induced cell migration and growth-cone collapse; Rho GTPase cycle; PCP/CE pathway; RHO GTPases Activate NADPH Oxidases,51,High,1
P49914,5-formyltetrahydrofolate cyclo-ligase OS=Homo sapiens OX=9606 GN=MTHFS PE=1 SV=2,0,26.887,15,3,34,3,203,23.2,7.88,18028,,3,,metabolic process,cytoplasm;cytosol;organelle lumen,catalytic activity;metal ion binding;nucleotide binding,Pf01812,10588,ENSG00000136371.10,MTHFS,15,One carbon pool by folate; Metabolic pathways,Folate Metabolism; One Carbon Metabolism,Metabolism of folate and pterines,8,High,1
Q9UBR2,Cathepsin Z OS=Homo sapiens OX=9606 GN=CTSZ PE=1 SV=1,0,26.865,18,4,76,4,303,33.8,7.11,36134,,4,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cell surface;endoplasmic reticulum;extracellular;membrane;organelle lumen;vacuole,catalytic activity;protein binding,Pf00112,1522,ENSG00000101160.13,CTSZ,20,Lysosome; Apoptosis,,Metabolism of Angiotensinogen to Angiotensins; Neutrophil degranulation; Cargo concentration in the ER; COPII (Coat Protein 2) Mediated Vesicle Transport; Lysosome Vesicle Biogenesis,19,High,1
P53609,Geranylgeranyl transferase type-1 subunit beta OS=Homo sapiens OX=9606 GN=PGGT1B PE=1 SV=2,0,26.857,15,6,32,6,377,42.3,6.83,12308,,6,,metabolic process;regulation of biological process;response to stimulus,,catalytic activity;metal ion binding,"Pf00432, Pf13249",5229,ENSG00000164219.9,PGGT1B,5,,,,0,High,1
Q96C03,Mitochondrial dynamics protein MID49 OS=Homo sapiens OX=9606 GN=MIEF2 PE=1 SV=1,0,26.842,12,3,11,3,454,49.2,5.12,4592,4.15,3,1,cell organization and biogenesis;regulation of biological process,membrane;mitochondrion,protein binding,Pf03281,125170,ENSG00000177427.12; ENSG00000284495.1,SMCR7; MIEF2,17; CHR_HSCHR17_3_CTG1,,,,0,High,1
Q12888,TP53-binding protein 1 OS=Homo sapiens OX=9606 GN=TP53BP1 PE=1 SV=2,0,26.806,4,6,27,6,1972,213.4,4.7,10079,,6,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;nucleus,DNA binding;protein binding,"Pf09038, Pf15057",7158,ENSG00000067369.13,TP53BP1,15,NOD-like receptor signaling pathway,ATM Signaling Pathway; ATM Signaling Network in Development and Disease,G2/M DNA damage checkpoint; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of transcription factors; Processing of DNA double-strand break ends; Nonhomologous End-Joining (NHEJ),20,High,1
O43760,Synaptogyrin-2 OS=Homo sapiens OX=9606 GN=SYNGR2 PE=1 SV=1,0,26.77,17,4,67,4,224,24.8,4.94,27582,0,4,1,cell organization and biogenesis;transport,membrane,protein binding,Pf01284,9144,ENSG00000108639.7,SYNGR2,17,,,,0,High,1
Q9H0L4,Cleavage stimulation factor subunit 2 tau variant OS=Homo sapiens OX=9606 GN=CSTF2T PE=1 SV=1,0,26.766,8,3,34,2,616,64.4,7.25,11248,,3,,metabolic process,nucleus,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259, Pf14304, Pf14327",23283,ENSG00000177613.8,CSTF2T,10,mRNA surveillance pathway,mRNA Processing,Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs; mRNA 3'-end processing; mRNA Splicing - Major Pathway,13,High,1
Q69YN2,CWF19-like protein 1 OS=Homo sapiens OX=9606 GN=CWF19L1 PE=1 SV=2,0,26.765,7,4,21,4,538,60.6,7.24,10198,,4,,,,catalytic activity,"Pf04676, Pf04677",55280,ENSG00000095485.16,CWF19L1,10,,,,0,High,1
Q15796,Mothers against decapentaplegic homolog 2 OS=Homo sapiens OX=9606 GN=SMAD2 PE=1 SV=1,0,26.76,8,3,44,2,467,52.3,6.58,21076,,3,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus,DNA binding;metal ion binding;protein binding;RNA binding;signal transducer activity,"Pf03165, Pf03166",4087,ENSG00000175387.15,SMAD2,18,FoxO signaling pathway; TGF-beta signaling pathway; Adherens junction; AGE-RAGE signaling pathway in diabetic complications; Hippo signaling pathway; Inflammatory bowel disease (IBD); Signaling pathways regulating pluripotency of stem cells; Chagas disease (American trypanosomiasis); Proteoglycans in cancer; Pathways in cancer; Cell cycle; HTLV-I infection; Colorectal cancer; Pancreatic cancer; Endocytosis,AGE/RAGE pathway; Endoderm Differentiation; Mesodermal Commitment Pathway; Extracellular vesicle-mediated signaling in recipient cells; TGF-beta Signaling Pathway; Hypothesized Pathways in Pathogenesis of Cardiovascular Disease; Tgif disruption of Shh signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition; Canonical and Non-Canonical TGF-B signaling; TGF-beta Receptor Signaling,Signaling by NODAL; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Transcriptional regulation of pluripotent stem cells; Ub-specific processing proteases; Downregulation of TGF-beta receptor signaling; SMAD4 MH2 Domain Mutants in Cancer; Signaling by Activin; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; TGFBR1 KD Mutants in Cancer,55,High,1
P07948,Tyrosine-protein kinase Lyn OS=Homo sapiens OX=9606 GN=LYN PE=1 SV=3,0,26.739,14,7,46,4,512,58.5,7.11,23918,,7,,cell communication;cell differentiation;cell organization and biogenesis;cellular component movement;coagulation;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;Golgi;membrane;nucleus;vacuole,catalytic activity;nucleotide binding;protein binding;signal transducer activity,"Pf00017, Pf00018, Pf00069, Pf07653, Pf07714, Pf14604",4067,ENSG00000254087.7,LYN,8,Epithelial cell signaling in Helicobacter pylori infection; NF-kappa B signaling pathway; Fc epsilon RI signaling pathway; Epstein-Barr virus infection; Chemokine signaling pathway; Fc gamma R-mediated phagocytosis; Long-term depression; B cell receptor signaling pathway; Platelet activation; Viral carcinogenesis,IL-5 Signaling Pathway; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; B Cell Receptor Signaling Pathway; IL-3 Signaling Pathway; Kit receptor signaling pathway; Chemokine signaling pathway; Microglia Pathogen Phagocytosis Pathway,FCERI mediated Ca+2 mobilization; PECAM1 interactions; Dectin-2 family; Cyclin D associated events in G1; CTLA4 inhibitory signaling; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; Platelet Adhesion to exposed collagen; CD209 (DC-SIGN) signaling; EPH-ephrin mediated repulsion of cells; CD22 mediated BCR regulation; EPHA-mediated growth cone collapse; EPHB-mediated forward signaling; Regulation of signaling by CBL; GPVI-mediated activation cascade; CD28 co-stimulation; FCGR activation; Regulation of KIT signaling; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Growth hormone receptor signaling,62,High,1
Q92544,Transmembrane 9 superfamily member 4 OS=Homo sapiens OX=9606 GN=TM9SF4 PE=1 SV=2,0,26.715,11,5,31,5,642,74.5,6.54,12594,,5,,cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport,endosome;Golgi;membrane,protein binding,Pf02990,9777,ENSG00000101337.15,TM9SF4,20,,,,0,High,1
Q03591,Complement factor H-related protein 1 OS=Homo sapiens OX=9606 GN=CFHR1 PE=1 SV=2,0,26.695,7,2,40,1,330,37.6,7.39,18540,,2,,metabolic process;regulation of biological process;response to stimulus,extracellular,protein binding,Pf00084,3078,ENSG00000244414.6,CFHR1,1,,,Regulation of Complement cascade,4,High,1
Q92743,Serine protease HTRA1 OS=Homo sapiens OX=9606 GN=HTRA1 PE=1 SV=1,0,26.695,15,5,34,4,480,51.3,7.83,12341,,5,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;extracellular;membrane,catalytic activity;protein binding,"Pf00050, Pf00089, Pf00219, Pf00595, Pf05579, Pf07648, Pf10459, Pf13180, Pf13365",5654,ENSG00000166033.11,HTRA1,10,,,Degradation of the extracellular matrix,2,High,1
P25189,Myelin protein P0 OS=Homo sapiens OX=9606 GN=MPZ PE=1 SV=1,0,26.692,21,5,30,5,248,27.5,9.54,13696,,5,,cell communication;regulation of biological process;transport,endoplasmic reticulum;membrane;vacuole,structural molecule activity,"Pf07686, Pf10570",4359,ENSG00000158887.15,MPZ,1,Cell adhesion molecules (CAMs),Neural Crest Differentiation,,2,High,1
P23470,Receptor-type tyrosine-protein phosphatase gamma OS=Homo sapiens OX=9606 GN=PTPRG PE=1 SV=4,0,26.691,5,6,18,6,1445,161.9,6.42,8700,,6,,metabolic process;regulation of biological process;response to stimulus,membrane,catalytic activity;protein binding;receptor activity;signal transducer activity,"Pf00041, Pf00102, Pf00194, Pf13350, Pf14566",5793,ENSG00000144724.19,PTPRG,3,,,,0,High,1
P11137,Microtubule-associated protein 2 OS=Homo sapiens OX=9606 GN=MAP2 PE=1 SV=4,0,26.682,4,6,27,6,1827,199.4,4.91,9035,,6,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol,protein binding;structural molecule activity,"Pf00418, Pf08377",4133,ENSG00000078018.19,MAP2,2,,Melatonin metabolism and effects; MAPK Cascade; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,,3,High,1
Q9UDT6,CAP-Gly domain-containing linker protein 2 OS=Homo sapiens OX=9606 GN=CLIP2 PE=1 SV=1,0,26.662,8,6,25,2,1046,115.8,6.73,10283,,6,,metabolic process;regulation of biological process,cytoplasm;cytoskeleton;Golgi,catalytic activity;motor activity;protein binding,"Pf01302, Pf01576, Pf02463, Pf04111, Pf05557, Pf08317, Pf10174, Pf12128, Pf15070",7461,ENSG00000106665.15,CLIP2,7,,,,0,High,1
Q9Y680,Peptidyl-prolyl cis-trans isomerase FKBP7 OS=Homo sapiens OX=9606 GN=FKBP7 PE=1 SV=2,0,26.654,21,5,22,5,222,25.8,6.32,10536,,5,,,,,,,,,,,,,0,High,1
P43353,Aldehyde dehydrogenase family 3 member B1 OS=Homo sapiens OX=9606 GN=ALDH3B1 PE=1 SV=1,0,26.654,5,4,75,1,468,51.8,7.62,35159,0,4,1,metabolic process;response to stimulus;transport,cytoplasm;cytosol;membrane,catalytic activity;protein binding,Pf00171,221,ENSG00000006534.15,ALDH3B1,11,beta-Alanine metabolism; Phenylalanine metabolism; Drug metabolism - cytochrome P450; Histidine metabolism; Metabolic pathways; Chemical carcinogenesis; Glycolysis / Gluconeogenesis; Metabolism of xenobiotics by cytochrome P450; Tyrosine metabolism,,Neutrophil degranulation; Sphingolipid de novo biosynthesis,16,High,1
O75146,Huntingtin-interacting protein 1-related protein OS=Homo sapiens OX=9606 GN=HIP1R PE=1 SV=2,0,26.641,6,6,37,6,1068,119.3,6.67,12886,,6,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion,catalytic activity;motor activity;protein binding,"Pf01417, Pf01576, Pf01608, Pf02463, Pf04111, Pf05701, Pf07651, Pf09731, Pf12128",9026,ENSG00000130787.13,HIP1R,12,,,Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis,6,High,1
Q9NW15,Anoctamin-10 OS=Homo sapiens OX=9606 GN=ANO10 PE=1 SV=2,0,26.616,11,5,17,5,660,76.3,7.4,6677,,5,,transport,membrane,transporter activity,Pf04547,55129,ENSG00000160746.12,ANO10,3,,,Stimuli-sensing channels,3,High,1
Q9UKE5,TRAF2 and NCK-interacting protein kinase OS=Homo sapiens OX=9606 GN=TNIK PE=1 SV=1,0,26.615,5,6,26,1,1360,154.8,7.17,11058,,6,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;endosome;membrane;nucleus,catalytic activity;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf00780, Pf07714, Pf14531",23043,ENSG00000154310.16,TNIK,3,,,Oxidative Stress Induced Senescence,4,High,1
P23219,Prostaglandin G/H synthase 1 OS=Homo sapiens OX=9606 GN=PTGS1 PE=1 SV=2,0,26.606,12,4,23,4,599,68.6,7.23,7562,,4,,defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;endoplasmic reticulum;Golgi;membrane;nucleus,antioxidant activity;catalytic activity;metal ion binding;protein binding,"Pf00008, Pf03098, Pf07974",5742,ENSG00000095303.14,PTGS1,9,Serotonergic synapse; Regulation of lipolysis in adipocytes; Arachidonic acid metabolism; Platelet activation; Metabolic pathways,Selenium Micronutrient Network; Eicosanoid Synthesis; Overview of nanoparticle effects; Prostaglandin Synthesis and Regulation,COX reactions; Synthesis of Prostaglandins (PG) and Thromboxanes (TX),17,High,1
Q5BKU9,Oxidoreductase-like domain-containing protein 1 OS=Homo sapiens OX=9606 GN=OXLD1 PE=2 SV=1,0,26.605,31,3,28,3,147,15.8,8.22,10879,,3,,,mitochondrion,,Pf09791,339229,ENSG00000204237.4,OXLD1,17,,,,0,High,1
P47914,60S ribosomal protein L29 OS=Homo sapiens OX=9606 GN=RPL29 PE=1 SV=2,0,26.603,14,5,56,5,159,17.7,11.66,27167,,5,,cell organization and biogenesis;metabolic process;transport,cytosol;membrane;ribosome,protein binding;RNA binding;structural molecule activity,Pf01779,6159,ENSG00000162244.10,RPL29,3,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
Q9H0U6,"39S ribosomal protein L18, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL18 PE=1 SV=1",0,26.601,36,4,19,4,180,20.6,9.54,9643,,4,,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion;ribosome,RNA binding;structural molecule activity,Pf00861,29074,ENSG00000112110.9,MRPL18,6,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
Q96LZ7,Regulator of microtubule dynamics protein 2 OS=Homo sapiens OX=9606 GN=RMDN2 PE=1 SV=2,0,26.596,17,6,20,6,410,47.4,6.54,7682,0,6,1,,cytoplasm;cytoskeleton;cytosol;membrane,protein binding,,151393,ENSG00000115841.19,FAM82A1; RMDN2,2,,,,0,High,1
Q86V88,Magnesium-dependent phosphatase 1 OS=Homo sapiens OX=9606 GN=MDP1 PE=1 SV=1,0,26.586,22,4,44,4,176,20.1,6.39,21620,,4,,metabolic process,,catalytic activity;metal ion binding;receptor activity;signal transducer activity,"Pf00702, Pf03031, Pf12689, Pf13419",145553,ENSG00000213920.8,MDP1,14,,,,0,High,1
P78310,Coxsackievirus and adenovirus receptor OS=Homo sapiens OX=9606 GN=CXADR PE=1 SV=1,0,26.554,21,6,31,6,365,40,7.56,10583,0,6,1,cell communication;cell organization and biogenesis;cellular component movement;defense response;regulation of biological process;response to stimulus;transport,cytoplasm;extracellular;membrane,protein binding;receptor activity,"Pf07679, Pf07686, Pf13895, Pf13927",1525,ENSG00000154639.18,CXADR,21,Viral myocarditis,,Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall,6,High,1
Q03426,Mevalonate kinase OS=Homo sapiens OX=9606 GN=MVK PE=1 SV=1,0,26.494,19,5,26,5,396,42.4,6.46,9927,,5,,metabolic process;regulation of biological process,cytoplasm;cytosol,catalytic activity;nucleotide binding;protein binding,Pf00288,4598,ENSG00000110921.13,MVK,12,Peroxisome; Metabolic pathways; Terpenoid backbone biosynthesis,Cholesterol Biosynthesis,Cholesterol biosynthesis; Activation of gene expression by SREBF (SREBP),10,High,1
Q5VT66,Mitochondrial amidoxime-reducing component 1 OS=Homo sapiens OX=9606 GN=MARC1 PE=1 SV=1,0,26.484,15,4,57,2,337,37.5,8.88,30607,5.08,3,1,metabolic process;response to stimulus,membrane;mitochondrion,catalytic activity;metal ion binding,"Pf03473, Pf03476",64757,ENSG00000186205.12,MARC1,1,,,Phase I - Functionalization of compounds,3,High,1
Q5JQF8,Polyadenylate-binding protein 1-like 2 OS=Homo sapiens OX=9606 GN=PABPC1L2A PE=2 SV=1,0,26.484,13,4,95,0,200,22.8,9.1,42505,,4,,,,RNA binding,"Pf00076, Pf13893, Pf14259",340529; 645974,ENSG00000184388.5; ENSG00000186288.5,PABPC1L2A; PABPC1L2B,X,RNA degradation; mRNA surveillance pathway; RNA transport,,,3,Not Found,1
Q6ZXV5,Protein O-mannosyl-transferase TMTC3 OS=Homo sapiens OX=9606 GN=TMTC3 PE=1 SV=2,0,26.483,9,6,38,6,915,103.9,8.87,15774,,6,,regulation of biological process;response to stimulus,endoplasmic reticulum;membrane,protein binding,"Pf00515, Pf07719, Pf08409, Pf13181, Pf13414, Pf13424, Pf13431, Pf13432, Pf14559",160418,,TMTC3,12,,,,0,High,1
P36959,GMP reductase 1 OS=Homo sapiens OX=9606 GN=GMPR PE=1 SV=1,0,26.48,20,5,76,4,345,37.4,7.06,32525,,5,,metabolic process;response to stimulus,cytosol,catalytic activity;metal ion binding,"Pf00478, Pf01645",2766,ENSG00000137198.9,GMPR,6,Purine metabolism,,Purine salvage,5,High,1
Q5JTY5,COBW domain-containing protein 3 OS=Homo sapiens OX=9606 GN=CBWD3 PE=2 SV=1,0,26.467,25,5,14,5,395,44,4.87,4518,,5,,,,nucleotide binding,"Pf02492, Pf07683",445571; 220869,ENSG00000196873.15,CBWD3; CBWD5,9,,,,0,High,1
Q8TAE6,Protein phosphatase 1 regulatory subunit 14C OS=Homo sapiens OX=9606 GN=PPP1R14C PE=1 SV=3,0,26.466,17,2,53,2,165,17.8,5.16,22313,,2,,regulation of biological process,cytoplasm;membrane,enzyme regulator activity,Pf05361,81706,ENSG00000198729.4,PPP1R14C,6,,,,0,High,1
Q10589,Bone marrow stromal antigen 2 OS=Homo sapiens OX=9606 GN=BST2 PE=1 SV=1,0,26.462,18,3,41,3,180,19.8,5.6,20195,,3,,cell communication;cell proliferation;cellular component movement;defense response;development;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;cytosol;endosome;Golgi;membrane,enzyme regulator activity;protein binding;RNA binding;signal transducer activity;transporter activity,,684,ENSG00000130303.12,BST2,19,,,Interferon alpha/beta signaling; Neutrophil degranulation,6,High,1
Q8WWX9,Selenoprotein M OS=Homo sapiens OX=9606 GN=SELENOM PE=1 SV=3,0,26.459,36,4,13,4,145,16.2,5.54,5207,,4,,metabolic process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;Golgi,protein binding,Pf08806,140606,ENSG00000198832.10,SELM; SELENOM,22,,Selenium Micronutrient Network; Selenium Metabolism and Selenoproteins,,2,High,1
P41218,Myeloid cell nuclear differentiation antigen OS=Homo sapiens OX=9606 GN=MNDA PE=1 SV=1,0,26.385,23,6,29,6,407,45.8,9.76,9210,,6,,cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;extracellular;nucleus;organelle lumen,DNA binding;protein binding;transporter activity,"Pf02758, Pf02760",4332,ENSG00000163563.7,MNDA,1,,,Neutrophil degranulation,3,High,1
Q13573,SNW domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SNW1 PE=1 SV=1,0,26.369,15,6,13,6,536,61.5,9.52,5696,,6,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,nucleus;spliceosomal complex,catalytic activity;protein binding;RNA binding,Pf02731,22938,ENSG00000100603.13,SNW1,14,Viral carcinogenesis; Notch signaling pathway; Epstein-Barr virus infection; Spliceosome,TGF-beta Signaling Pathway; RIG-I-like Receptor Signaling; Notch Signaling Pathway,NOTCH1 Intracellular Domain Regulates Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; mRNA Splicing - Major Pathway; Constitutive Signaling by NOTCH1 PEST Domain Mutants; RUNX3 regulates NOTCH signaling; Notch-HLH transcription pathway; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Pre-NOTCH Transcription and Translation,34,High,1
Q9BS40,Latexin OS=Homo sapiens OX=9606 GN=LXN PE=1 SV=2,0,26.364,17,3,20,3,222,25.7,5.78,8045,0,3,1,defense response;regulation of biological process;response to stimulus,cytoplasm,enzyme regulator activity;protein binding,Pf06907,56925,ENSG00000079257.7,LXN,3,,,,0,High,1
P17050,Alpha-N-acetylgalactosaminidase OS=Homo sapiens OX=9606 GN=NAGA PE=1 SV=2,0,26.357,15,5,11,5,411,46.5,5.19,4096,,5,,metabolic process,cytoplasm;vacuole,catalytic activity;protein binding,Pf02065,4668,ENSG00000198951.11,NAGA,22,Lysosome; Glycosphingolipid biosynthesis - globo and isoglobo series,,,2,High,1
Q05469,Hormone-sensitive lipase OS=Homo sapiens OX=9606 GN=LIPE PE=1 SV=4,0,26.349,8,7,15,7,1076,116.5,6.7,6328,,7,,metabolic process,cytoplasm;cytosol;membrane,catalytic activity;protein binding,"Pf06350, Pf07859, Pf09770, Pf10340, Pf12695",3991,ENSG00000079435.9,LIPE,19,AMPK signaling pathway; Regulation of lipolysis in adipocytes; Aldosterone synthesis and secretion; Insulin signaling pathway; cAMP signaling pathway,AMP-activated Protein Kinase (AMPK) Signaling; Fatty Acid Beta Oxidation; Adipogenesis; Triacylglyceride Synthesis; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Insulin Signaling,Triglyceride catabolism,15,High,1
P62341,Thioredoxin reductase-like selenoprotein T OS=Homo sapiens OX=9606 GN=SELENOT PE=1 SV=2,0,26.333,27,4,24,4,195,22.3,8.6,10611,,4,,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;membrane,antioxidant activity;catalytic activity,Pf10262,51714,ENSG00000198843.12,SELT; SELENOT,3,,Selenium Micronutrient Network; Selenium Metabolism and Selenoproteins,,2,High,1
P83731,60S ribosomal protein L24 OS=Homo sapiens OX=9606 GN=RPL24 PE=1 SV=1,0,26.332,19,3,134,3,157,17.8,11.25,68023,0,3,1,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;membrane;ribosome,protein binding;RNA binding;structural molecule activity,Pf01246,6152,ENSG00000114391.12,RPL24,3,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
Q12965,Unconventional myosin-Ie OS=Homo sapiens OX=9606 GN=MYO1E PE=1 SV=2,0,26.274,6,6,24,1,1108,127,8.92,9198,,6,,cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton,catalytic activity;motor activity;nucleotide binding;protein binding,"Pf00018, Pf00063, Pf06017, Pf07653, Pf14604",4643,ENSG00000157483.8,MYO1E,15,,Primary Focal Segmental Glomerulosclerosis FSGS,,1,High,1
Q8IZH2,5'-3' exoribonuclease 1 OS=Homo sapiens OX=9606 GN=XRN1 PE=1 SV=1,0,26.272,3,5,25,5,1706,194,7.21,11508,,5,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,catalytic activity;DNA binding;protein binding;RNA binding,Pf03159,54464,ENSG00000114127.10,XRN1,3,RNA degradation; Ribosome biogenesis in eukaryotes,,"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; mRNA decay by 5' to 3' exoribonuclease",8,High,1
Q9BVG4,Protein PBDC1 OS=Homo sapiens OX=9606 GN=PBDC1 PE=1 SV=1,0,26.262,24,5,33,5,233,26,4.79,15336,,5,,,cytoplasm,,Pf04669,51260,ENSG00000102390.10,CXorf26; PBDC1,X,,,,0,High,1
Q9H1P3,Oxysterol-binding protein-related protein 2 OS=Homo sapiens OX=9606 GN=OSBPL2 PE=1 SV=1,0,26.256,13,4,14,4,480,55.2,6.35,5013,,4,,metabolic process;transport,cytosol,protein binding;transporter activity,Pf01237,9885,ENSG00000130703.15,OSBPL2,20,,,Synthesis of bile acids and bile salts,5,High,1
Q9NX58,Cell growth-regulating nucleolar protein OS=Homo sapiens OX=9606 GN=LYAR PE=1 SV=2,0,26.244,19,4,8,4,379,43.6,9.54,3851,,4,,,nucleus,metal ion binding;protein binding;RNA binding,Pf08790,55646,,LYAR,4,,,,0,High,1
Q96DM3,Regulator of MON1-CCZ1 complex OS=Homo sapiens OX=9606 GN=RMC1 PE=1 SV=2,0,26.243,11,6,28,6,657,74.9,7.83,11168,,6,,,membrane,protein binding,Pf07035,29919,ENSG00000141452.9,C18orf8; WDR98,18,,,,0,High,1
O15127,Secretory carrier-associated membrane protein 2 OS=Homo sapiens OX=9606 GN=SCAMP2 PE=1 SV=2,0,26.224,10,2,13,2,329,36.6,6.1,6257,,2,,transport,endosome;Golgi;membrane,protein binding,Pf04144,10066,ENSG00000140497.16,SCAMP2,15,,Serotonin Transporter Activity; Monoamine Transport,,2,High,1
Q9Y679,Ancient ubiquitous protein 1 OS=Homo sapiens OX=9606 GN=AUP1 PE=1 SV=2,0,26.217,13,4,10,4,410,45.8,8.65,5174,,4,,,,,,,,,,,,,0,High,1
Q9H7C4,Syncoilin OS=Homo sapiens OX=9606 GN=SYNC PE=1 SV=3,0,26.203,17,7,22,6,482,55.3,4.61,8443,,7,,,cytoplasm;cytosol;membrane,structural molecule activity,Pf00038,81493,ENSG00000162520.14,SYNC,1,,,,0,High,1
Q9Y478,5'-AMP-activated protein kinase subunit beta-1 OS=Homo sapiens OX=9606 GN=PRKAB1 PE=1 SV=4,0,26.145,32,5,63,4,270,30.4,6.4,28349,,5,,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytosol;nucleus,catalytic activity;protein binding,"Pf02922, Pf04739",5564,ENSG00000111725.10,PRKAB1,12,Circadian rhythm; Glucagon signaling pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Non-alcoholic fatty liver disease (NAFLD); Oxytocin signaling pathway; Longevity regulating pathway - multiple species; Hypertrophic cardiomyopathy (HCM); Insulin resistance; AMPK signaling pathway; FoxO signaling pathway; Longevity regulating pathway,AMP-activated Protein Kinase (AMPK) Signaling; Target Of Rapamycin (TOR) Signaling; Energy Metabolism; Sterol Regulatory Element-Binding Proteins (SREBP) signalling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Angiopoietin Like Protein 8 Regulatory Pathway; Leptin and adiponectin,Translocation of GLUT4 to the plasma membrane; Energy dependent regulation of mTOR by LKB1-AMPK; TP53 Regulates Metabolic Genes; Regulation of TP53 Activity through Phosphorylation; Macroautophagy; Activation of PPARGC1A (PGC-1alpha) by phosphorylation,37,High,1
P48740,Mannan-binding lectin serine protease 1 OS=Homo sapiens OX=9606 GN=MASP1 PE=1 SV=3,0,26.125,12,4,16,4,699,79.2,5.49,6291,2.67,3,1,defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;extracellular,catalytic activity;metal ion binding;protein binding,"Pf00084, Pf00089, Pf00431, Pf07645, Pf12662, Pf14670",5648,ENSG00000127241.16,MASP1,3,Complement and coagulation cascades; Staphylococcus aureus infection,Complement Activation; Complement and Coagulation Cascades,Ficolins bind to repetitive carbohydrate structures on the target cell surface; Scavenging by Class A Receptors,14,High,1
Q5T2E6,Armadillo-like helical domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ARMH3 PE=1 SV=1,0,26.106,12,7,16,7,689,78.7,6.6,5851,,7,,,membrane,protein binding,Pf08427,79591,ENSG00000120029.12,C10orf76,10,,,,0,High,1
Q5VUM1,"Succinate dehydrogenase assembly factor 4, mitochondrial OS=Homo sapiens OX=9606 GN=SDHAF4 PE=3 SV=1",0,26.072,24,3,31,3,108,12.2,9.36,9995,0,3,1,cell organization and biogenesis;defense response;metabolic process;response to stimulus,mitochondrion;organelle lumen,catalytic activity,Pf07896,135154,ENSG00000154079.5,C6orf57; SDHAF4,6,,,,0,High,1
Q6QEF8-3,Isoform 3 of Coronin-6 OS=Homo sapiens OX=9606 GN=CORO6,0,26.063,19,3,48,1,285,31.6,5.27,17868,21.58,2,2,cell organization and biogenesis,cytoskeleton,protein binding,Pf08954,84940,,CORO6,17,,,,0,High,1
O43677,"NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFC1 PE=1 SV=1",0,26.053,28,2,85,2,76,8.7,10.2,41524,,2,,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion,catalytic activity,Pf15088,4717,ENSG00000109390.11,NDUFC1,4,Parkinson's disease; Non-alcoholic fatty liver disease (NAFLD); Alzheimer's disease; Huntington's disease; Metabolic pathways; Oxidative phosphorylation,Electron Transport Chain; Oxidative phosphorylation,Complex I biogenesis,13,High,1
O43617,Trafficking protein particle complex subunit 3 OS=Homo sapiens OX=9606 GN=TRAPPC3 PE=1 SV=1,0,26.032,28,5,46,5,180,20.3,4.96,22433,,5,,cell organization and biogenesis;transport,cytosol;endoplasmic reticulum;Golgi;membrane,protein binding,Pf04051,27095,ENSG00000054116.11,TRAPPC3,1,,,RAB GEFs exchange GTP for GDP on RABs; COPII (Coat Protein 2) Mediated Vesicle Transport,10,High,1
P49961,Ectonucleoside triphosphate diphosphohydrolase 1 OS=Homo sapiens OX=9606 GN=ENTPD1 PE=1 SV=1,0,26.028,7,3,27,2,510,57.9,6.34,12193,0,3,1,coagulation;metabolic process,membrane,catalytic activity;nucleotide binding;protein binding,Pf01150,953,ENSG00000138185.18,ENTPD1,10,Epstein-Barr virus infection; Pyrimidine metabolism; Purine metabolism,,Phosphate bond hydrolysis by NTPDase proteins,7,High,1
O75348,V-type proton ATPase subunit G 1 OS=Homo sapiens OX=9606 GN=ATP6V1G1 PE=1 SV=3,0,26.028,30,3,38,3,118,13.7,8.79,21130,,3,,cellular homeostasis;regulation of biological process;response to stimulus;transport,cytosol;membrane,catalytic activity;protein binding;transporter activity,Pf03179,9550,ENSG00000136888.6,ATP6V1G1,9,Metabolic pathways; mTOR signaling pathway; Rheumatoid arthritis; Epithelial cell signaling in Helicobacter pylori infection; Oxidative phosphorylation; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Phagosome,Osteoclast Signaling,"Transferrin endocytosis and recycling; ROS, RNS production in phagocytes; Ion channel transport; Insulin receptor recycling",21,High,1
P85037,Forkhead box protein K1 OS=Homo sapiens OX=9606 GN=FOXK1 PE=1 SV=1,0,26.026,13,5,16,5,733,75.4,9.32,5915,,5,,cell differentiation;development;metabolic process;regulation of biological process,nucleus,DNA binding;protein binding,"Pf00250, Pf00498",221937,ENSG00000164916.10,FOXK1,7,,,UCH proteinases,4,High,1
P51153,Ras-related protein Rab-13 OS=Homo sapiens OX=9606 GN=RAB13 PE=1 SV=1,0,26.011,25,5,156,2,203,22.8,9.19,79972,,5,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;endosome;Golgi;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf00735, Pf04670, Pf08477",5872,ENSG00000143545.8,RAB13,1,Tight junction,,Translocation of GLUT4 to the plasma membrane; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation,9,High,1
Q9HCL2,"Glycerol-3-phosphate acyltransferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=GPAM PE=1 SV=3",0,25.988,7,5,17,5,828,93.7,7.74,7369,,5,,defense response;metabolic process;regulation of biological process;response to stimulus;transport,membrane;mitochondrion,catalytic activity,Pf01553,57678,ENSG00000119927.13,GPAM,10,Metabolic pathways; Glycerolipid metabolism; Glycerophospholipid metabolism,Sterol Regulatory Element-Binding Proteins (SREBP) signalling; Estrogen Receptor Pathway; Triacylglyceride Synthesis,Synthesis of PA; Triglyceride biosynthesis; Activation of gene expression by SREBF (SREBP); RUNX1 regulates estrogen receptor mediated transcription,21,High,1
Q9BYC9,"39S ribosomal protein L20, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL20 PE=1 SV=1",0,25.955,33,4,46,4,149,17.4,10.86,18406,,4,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,protein binding;RNA binding;structural molecule activity,Pf00453,55052,ENSG00000242485.5,MRPL20,1,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
Q9ULX6,A-kinase anchor protein 8-like OS=Homo sapiens OX=9606 GN=AKAP8L PE=1 SV=4,0,25.932,13,6,20,6,646,71.6,5.05,7498,,6,,cell organization and biogenesis;metabolic process;regulation of biological process,chromosome;cytoplasm;nucleus,DNA binding;metal ion binding;protein binding;RNA binding,Pf04988,26993,ENSG00000011243.17,AKAP8L,19,Epstein-Barr virus infection,,,1,High,1
Q10588,ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 OS=Homo sapiens OX=9606 GN=BST1 PE=1 SV=2,0,25.922,16,5,36,5,318,35.7,7.8,15287,,5,,metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity,Pf02267,683,ENSG00000109743.10,BST1,4,Pancreatic secretion; Nicotinate and nicotinamide metabolism; Metabolic pathways; Salivary secretion,NAD+ biosynthetic pathways,Neutrophil degranulation; Post-translational modification: synthesis of GPI-anchored proteins; Nicotinate metabolism,15,High,1
O94855,Protein transport protein Sec24D OS=Homo sapiens OX=9606 GN=SEC24D PE=1 SV=2,0,25.915,7,4,15,4,1032,112.9,7.25,6198,,4,,cell organization and biogenesis;transport,cytoplasm;cytosol;endoplasmic reticulum;membrane,metal ion binding;protein binding,"Pf00626, Pf04810, Pf04811, Pf04815, Pf08033",9871,ENSG00000150961.14,SEC24D,4,Protein processing in endoplasmic reticulum,Sterol Regulatory Element-Binding Proteins (SREBP) signalling,"Regulation of cholesterol biosynthesis by SREBP (SREBF); Cargo concentration in the ER; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; COPII (Coat Protein 2) Mediated Vesicle Transport; MHC class II antigen presentation",20,High,1
P48507,Glutamate--cysteine ligase regulatory subunit OS=Homo sapiens OX=9606 GN=GCLM PE=1 SV=1,0,25.911,22,5,23,5,274,30.7,6.02,9054,,5,,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cytosol,catalytic activity;enzyme regulator activity;protein binding,Pf00248,2730,ENSG00000023909.9,GCLM,1,Cysteine and methionine metabolism; Glutathione metabolism; Metabolic pathways,Glutathione metabolism; Trans-sulfuration pathway; Trans-sulfuration and one carbon metabolism; NRF2 pathway; Transcriptional activation by NRF2; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Amino Acid metabolism; One carbon metabolism and related pathways,Glutathione synthesis and recycling,16,High,1
Q9UJC5,SH3 domain-binding glutamic acid-rich-like protein 2 OS=Homo sapiens OX=9606 GN=SH3BGRL2 PE=1 SV=2,0,25.871,41,3,48,3,107,12.3,6.71,25152,,3,,cellular homeostasis;regulation of biological process,cytoplasm;membrane;nucleus,catalytic activity;protein binding,"Pf00462, Pf04908",83699,ENSG00000198478.7,SH3BGRL2,6,,,,0,High,1
Q15785,Mitochondrial import receptor subunit TOM34 OS=Homo sapiens OX=9606 GN=TOMM34 PE=1 SV=2,0,25.859,19,6,22,6,309,34.5,8.98,9170,,6,,transport,cytoplasm;cytosol;membrane;mitochondrion;nucleus,protein binding,"Pf00515, Pf07719, Pf12895, Pf13414",10953,ENSG00000025772.7,TOMM34,20,,,,0,High,1
Q99426,Tubulin-folding cofactor B OS=Homo sapiens OX=9606 GN=TBCB PE=1 SV=2,0,25.835,16,4,44,4,244,27.3,5.15,26159,,4,,cell differentiation;development,cytoplasm;cytoskeleton;cytosol,protein binding,"Pf01302, Pf14560",1155,ENSG00000105254.11,TBCB,19,,,Post-chaperonin tubulin folding pathway,3,High,1
Q9NYB0,Telomeric repeat-binding factor 2-interacting protein 1 OS=Homo sapiens OX=9606 GN=TERF2IP PE=1 SV=1,0,25.829,14,5,12,5,399,44.2,4.73,5506,,5,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;cytosol;nucleus,DNA binding;protein binding,"Pf08914, Pf11626",54386,ENSG00000166848.5,TERF2IP,16,,,Meiotic synapsis; DNA Damage/Telomere Stress Induced Senescence; Packaging Of Telomere Ends,11,High,1
Q9NZ43,Vesicle transport protein USE1 OS=Homo sapiens OX=9606 GN=USE1 PE=1 SV=2,0,25.829,24,5,31,5,259,29.4,9.07,14840,,5,,metabolic process;transport,endoplasmic reticulum;membrane;vacuole,protein binding,Pf09753,55850,ENSG00000053501.12,USE1,19,SNARE interactions in vesicular transport,,COPI-dependent Golgi-to-ER retrograde traffic,6,High,1
P28065,Proteasome subunit beta type-9 OS=Homo sapiens OX=9606 GN=PSMB9 PE=1 SV=2,0,25.826,31,5,22,5,219,23.3,5.03,9434,,5,,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus;proteasome,catalytic activity;protein binding,Pf00227,5698,ENSG00000239836.7; ENSG00000243594.7; ENSG00000243067.7; ENSG00000240065.7; ENSG00000240118.7,PSMB9,6; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_DBB_CTG1,Proteasome,Proteasome Degradation; Type II interferon signaling (IFNG),Regulation of RAS by GAPs; CDT1 association with the CDC6:ORC:origin complex; Downstream TCR signaling; UCH proteinases; NIK-->noncanonical NF-kB signaling; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; SCF-beta-TrCP mediated degradation of Emi1; Cross-presentation of soluble exogenous antigens (endosomes); Separation of Sister Chromatids; Vpu mediated degradation of CD4; Hedgehog ligand biogenesis; Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; ER-Phagosome pathway; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; ABC-family proteins mediated transport; Regulation of activated PAK-2p34 by proteasome mediated degradation; CDK-mediated phosphorylation and removal of Cdc6; FCERI mediated NF-kB activation; Neddylation; Autodegradation of the E3 ubiquitin ligase COP1; G2/M Checkpoints; Regulation of RUNX3 expression and activity; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; Removal of licensing factors from origins; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of DNA replication; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; SCF(Skp2)-mediated degradation of p27/p21; APC/C:Cdc20 mediated degradation of Securin; Interleukin-1 family signaling; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of ornithine decarboxylase (ODC); Interleukin-20 family signaling; Hedgehog 'on' state; Ubiquitin-dependent degradation of Cyclin D1; Degradation of DVL; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of AXIN; Autodegradation of Cdh1 by Cdh1:APC/C; Asymmetric localization of PCP proteins; Orc1 removal from chromatin; M/G1 Transition; Activation of NF-kappaB in B cells; Degradation of beta-catenin by the destruction complex; MAPK6/MAPK4 signaling; Dectin-1 mediated noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis,151,High,1
O60341,Lysine-specific histone demethylase 1A OS=Homo sapiens OX=9606 GN=KDM1A PE=1 SV=2,0,25.798,9,5,19,5,852,92.8,6.52,7540,,5,,cell organization and biogenesis;coagulation;development;metabolic process;regulation of biological process;response to stimulus,nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding,"Pf01593, Pf04433, Pf13450, Pf13870",23028,ENSG00000004487.15,KDM1A,1,,Androgen receptor signaling pathway,Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Regulation of PTEN gene transcription; HDACs deacetylate histones; HDMs demethylate histones; Factors involved in megakaryocyte development and platelet production,16,High,1
Q13428,Treacle protein OS=Homo sapiens OX=9606 GN=TCOF1 PE=1 SV=3,0,25.794,7,7,21,7,1488,152,9.04,6417,,7,,cell organization and biogenesis;regulation of biological process;transport,cytosol;nucleus,protein binding;RNA binding;transporter activity,Pf03546,6949,ENSG00000070814.17,TCOF1,5,Ribosome biogenesis in eukaryotes,,,1,High,1
Q86U42,Polyadenylate-binding protein 2 OS=Homo sapiens OX=9606 GN=PABPN1 PE=1 SV=3,0,25.787,31,5,18,2,306,32.7,5.06,6924,,5,,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;nucleus,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",8106,ENSG00000100836.10,PABPN1,14,mRNA surveillance pathway; Influenza A,mRNA Processing,Inhibition of Host mRNA Processing and RNA Silencing; mRNA 3'-end processing; mRNA Splicing - Major Pathway; Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs,20,High,1
Q9P299,Coatomer subunit zeta-2 OS=Homo sapiens OX=9606 GN=COPZ2 PE=2 SV=1,0,25.775,29,4,16,4,210,23.5,5.17,6524,,4,,transport,cytoplasm;cytosol;Golgi;membrane,,Pf01217,51226,ENSG00000005243.9,COPZ2,17,,,COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport,11,High,1
Q8ND30,Liprin-beta-2 OS=Homo sapiens OX=9606 GN=PPFIBP2 PE=1 SV=3,0,25.727,6,5,38,2,876,98.5,6.27,16552,,5,,,cytosol,protein binding,"Pf00536, Pf02920, Pf05667, Pf07647",8495,ENSG00000166387.11,PPFIBP2,11,,Ectoderm Differentiation,Receptor-type tyrosine-protein phosphatases,4,High,1
Q8TB36,Ganglioside-induced differentiation-associated protein 1 OS=Homo sapiens OX=9606 GN=GDAP1 PE=1 SV=3,0,25.718,20,5,18,5,358,41.3,8.34,6594,,5,,cell communication;cell organization and biogenesis;metabolic process;response to stimulus;transport,cytoplasm;cytosol;membrane;mitochondrion;nucleus,catalytic activity;protein binding,"Pf00043, Pf02798, Pf13409, Pf13410, Pf13417, Pf14497",54332,ENSG00000104381.12,GDAP1,8,,,,0,High,1
Q96SI9,Spermatid perinuclear RNA-binding protein OS=Homo sapiens OX=9606 GN=STRBP PE=1 SV=1,0,25.709,9,5,39,2,672,73.6,8.72,16111,,5,,cell differentiation;development;response to stimulus,cytoplasm;cytoskeleton;nucleus,DNA binding;protein binding;RNA binding,"Pf00035, Pf07528, Pf14709",55342,ENSG00000165209.18,STRBP,9,,,,0,High,1
Q00535,Cyclin-dependent-like kinase 5 OS=Homo sapiens OX=9606 GN=CDK5 PE=1 SV=3,0,25.675,27,7,30,7,292,33.3,7.66,11555,,7,,cell communication;cell death;cell differentiation;cell division;cell growth;cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf07714",1020,ENSG00000164885.12,CDK5,7,Axon guidance; Cocaine addiction; Alzheimer's disease,miRNA Regulation of DNA Damage Response; Nicotine Activity on Dopaminergic Neurons; Alzheimers Disease; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; ATM Signaling Network in Development and Disease; DNA Damage Response,Signaling by GPCR; DARPP-32 events; CRMPs in Sema3A signaling; Regulation of TP53 Activity through Phosphorylation; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Factors involved in megakaryocyte development and platelet production,28,High,1
Q16630,Cleavage and polyadenylation specificity factor subunit 6 OS=Homo sapiens OX=9606 GN=CPSF6 PE=1 SV=2,0,25.66,11,5,27,5,551,59.2,7.15,10570,,5,,cell organization and biogenesis;metabolic process,membrane;nucleus,protein binding;RNA binding,"Pf00076, Pf14259",11052,ENSG00000111605.16,CPSF6,12,mRNA surveillance pathway,,Signaling by cytosolic FGFR1 fusion mutants,7,High,1
P98082,Disabled homolog 2 OS=Homo sapiens OX=9606 GN=DAB2 PE=1 SV=3,0,25.629,9,5,17,5,770,82.4,5.53,7599,,5,,cell death;cell differentiation;cell organization and biogenesis;cell proliferation;development;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane,protein binding;receptor activity,Pf00640,1601,ENSG00000153071.14,DAB2,5,Endocytosis,Endoderm Differentiation; TGF-beta Signaling Pathway,Cargo recognition for clathrin-mediated endocytosis; Formation of annular gap junctions,11,High,1
Q5T0N5,Formin-binding protein 1-like OS=Homo sapiens OX=9606 GN=FNBP1L PE=1 SV=3,0,25.615,9,4,11,4,605,70,6.64,4798,,4,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;membrane,protein binding,"Pf00018, Pf00611, Pf07653, Pf08239, Pf14604",54874,ENSG00000137942.16,FNBP1L,1,,,Clathrin-mediated endocytosis,3,High,1
Q96LD8,Sentrin-specific protease 8 OS=Homo sapiens OX=9606 GN=SENP8 PE=1 SV=1,0,25.615,15,3,19,3,212,24.1,5.97,9342,,3,,metabolic process,cytosol;nucleus,catalytic activity,Pf02902,123228,ENSG00000166192.14,SENP8,15,,,UCH proteinases; Neddylation,5,High,1
P08910,Monoacylglycerol lipase ABHD2 OS=Homo sapiens OX=9606 GN=ABHD2 PE=1 SV=1,0,25.611,15,5,12,5,425,48.3,6.7,6039,,5,,metabolic process;regulation of biological process;response to stimulus;transport,membrane,catalytic activity;receptor activity;signal transducer activity,"Pf00561, Pf12697",11057,ENSG00000140526.17,ABHD2,15,,,,0,High,1
P43251,Biotinidase OS=Homo sapiens OX=9606 GN=BTD PE=1 SV=2,0,25.609,14,5,24,5,543,61.1,6.25,9238,,5,,metabolic process,extracellular;organelle lumen,catalytic activity,Pf00795,686,ENSG00000169814.12,BTD,3,Biotin metabolism; Metabolic pathways; Vitamin digestion and absorption,,Defective BTD causes biotidinase deficiency; Biotin transport and metabolism,12,High,1
P83916,Chromobox protein homolog 1 OS=Homo sapiens OX=9606 GN=CBX1 PE=1 SV=1,0,25.607,22,3,38,2,185,21.4,4.93,15855,,3,,regulation of biological process,chromosome;nucleus,protein binding,"Pf00385, Pf01393",10951,ENSG00000108468.14,CBX1,17,,,,0,High,1
P05090,Apolipoprotein D OS=Homo sapiens OX=9606 GN=APOD PE=1 SV=1,0,25.591,26,6,105,6,189,21.3,5.15,45624,,6,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;extracellular;ribosome,protein binding;transporter activity,"Pf00061, Pf03973, Pf08212",347,ENSG00000189058.8,APOD,3,,,Transport of fatty acids,4,High,1
A0A075B6P5,Immunoglobulin kappa variable 2-28 OS=Homo sapiens OX=9606 GN=IGKV2-28 PE=3 SV=1,0,25.547,23,4,65,2,120,12.9,5.94,35043,,4,,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity,Pf07679,28883; 28921,ENSG00000282025.1; ENSG00000244116.3; ENSG00000242534.2,IGKV2D-28; IGKV2-28,CHR_HG2290_PATCH; 2,,,FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis,26,High,1
P29972,Aquaporin-1 OS=Homo sapiens OX=9606 GN=AQP1 PE=1 SV=3,0,25.542,13,2,24,2,269,28.5,7.42,11605,,2,,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;membrane;nucleus,protein binding;transporter activity,Pf00230,358,ENSG00000240583.11,AQP1,7,Proximal tubule bicarbonate reclamation; Renin secretion; Bile secretion,Spinal Cord Injury,Passive transport by Aquaporins; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide; Vasopressin regulates renal water homeostasis via Aquaporins,11,High,1
Q9Y639-5,Isoform 5 of Neuroplastin OS=Homo sapiens OX=9606 GN=NPTN,0,25.525,11,4,67,1,394,43.9,8.53,27055,11.29,3,1,cellular homeostasis;regulation of biological process;response to stimulus,cell surface,protein binding,"Pf00047, Pf07679, Pf07686, Pf13895, Pf13927",27020,ENSG00000156642.16,NPTN,15,,,,0,High,1
Q14739,Delta(14)-sterol reductase LBR OS=Homo sapiens OX=9606 GN=LBR PE=1 SV=2,0,25.494,10,6,16,6,615,70.7,9.36,5829,,6,,metabolic process,membrane;nucleus,catalytic activity;DNA binding;protein binding;RNA binding,"Pf01222, Pf06966, Pf09465",3930,ENSG00000143815.14,LBR,1,,Gastric cancer network 2; ATM Signaling Network in Development and Disease,Cholesterol biosynthesis,6,High,1
Q15651,High mobility group nucleosome-binding domain-containing protein 3 OS=Homo sapiens OX=9606 GN=HMGN3 PE=1 SV=2,0,25.465,15,2,247,1,99,10.7,9.66,130934,,2,,cell organization and biogenesis;regulation of biological process,chromosome;cytosol;nucleus,DNA binding;protein binding,,9324,ENSG00000118418.14,HMGN3,6,,,,0,High,1
Q7Z6B0,Coiled-coil domain-containing protein 91 OS=Homo sapiens OX=9606 GN=CCDC91 PE=1 SV=2,0,25.44,10,5,21,5,441,49.9,5.07,10290,,5,,transport,cytosol;Golgi;membrane,protein binding,,55297,ENSG00000123106.10,CCDC91,12,,,,0,High,1
Q9Y639,Neuroplastin OS=Homo sapiens OX=9606 GN=NPTN PE=1 SV=2,0,25.431,12,4,67,1,398,44.4,7.99,27764,,4,,cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus,cell surface;membrane,protein binding,"Pf00047, Pf07679, Pf07686, Pf13895, Pf13927",27020,ENSG00000156642.16,NPTN,15,,,Neurotransmitter receptors and postsynaptic signal transmission,3,High,1
Q6DKJ4,Nucleoredoxin OS=Homo sapiens OX=9606 GN=NXN PE=1 SV=2,0,25.428,23,8,28,8,435,48.4,4.97,10093,,8,,cell differentiation;cellular homeostasis;development;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,antioxidant activity;catalytic activity,"Pf00085, Pf00578, Pf13098, Pf13899, Pf13905, Pf14595",64359,ENSG00000167693.16,NXN,17,,,,0,High,1
Q9H6F2,Trimeric intracellular cation channel type A OS=Homo sapiens OX=9606 GN=TMEM38A PE=1 SV=1,0,25.421,18,4,41,4,299,33.2,8.29,10761,32.21,2,2,transport,endoplasmic reticulum;membrane;nucleus,transporter activity,Pf05197,79041,ENSG00000072954.6,TMEM38A,19,,,,0,High,1
Q8N5X7,Eukaryotic translation initiation factor 4E type 3 OS=Homo sapiens OX=9606 GN=EIF4E3 PE=2 SV=4,0,25.42,17,3,29,3,224,24.4,6.42,11692,,3,,metabolic process;regulation of biological process,cytoplasm;cytosol,RNA binding,Pf01652,317649,ENSG00000163412.12,EIF4E3,3,,,ISG15 antiviral mechanism,5,High,1
P62851,40S ribosomal protein S25 OS=Homo sapiens OX=9606 GN=RPS25 PE=1 SV=1,0,25.407,22,4,200,4,125,13.7,10.11,97844,,4,,cell organization and biogenesis;metabolic process;transport,cytosol;nucleus;ribosome,catalytic activity;nucleotide binding;protein binding;RNA binding;structural molecule activity,Pf03297,6230,ENSG00000280831.2; ENSG00000118181.10,RPS25,11; CHR_HG2217_PATCH,Ribosome,Cytoplasmic Ribosomal Proteins,"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane",38,High,1
O14957,Cytochrome b-c1 complex subunit 10 OS=Homo sapiens OX=9606 GN=UQCR11 PE=1 SV=1,0,25.405,64,2,178,2,56,6.6,9.88,86410,3,1,1,metabolic process;transport,membrane;mitochondrion,catalytic activity;transporter activity,Pf08997,10975,ENSG00000127540.11; ENSG00000267059.2,UQCR11,19,Alzheimer's disease; Metabolic pathways; Huntington's disease; Oxidative phosphorylation; Parkinson's disease; Cardiac muscle contraction; Non-alcoholic fatty liver disease (NAFLD),Electron Transport Chain,Respiratory electron transport,12,High,1
Q8NE86,"Calcium uniporter protein, mitochondrial OS=Homo sapiens OX=9606 GN=MCU PE=1 SV=1",0,25.4,15,5,30,5,351,39.8,8.65,9042,0,5,1,cell organization and biogenesis;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,membrane;mitochondrion,catalytic activity;protein binding;transporter activity,Pf04678,90550,ENSG00000156026.14,MCU,10,NOD-like receptor signaling pathway; Calcium signaling pathway,,Processing of SMDT1,5,High,1
Q9UJ41,Rab5 GDP/GTP exchange factor OS=Homo sapiens OX=9606 GN=RABGEF1 PE=1 SV=3,0,25.398,11,5,16,5,491,56.9,7.02,8082,,5,,,,,,,,,,,,,0,High,1
Q9C0D9,Ethanolaminephosphotransferase 1 OS=Homo sapiens OX=9606 GN=SELENOI PE=1 SV=3,0,25.397,13,3,21,3,397,45.2,6.6,9092,,3,,metabolic process,membrane,catalytic activity;metal ion binding,Pf01066,85465,ENSG00000138018.17,EPT1; SELENOI,2,Metabolic pathways; Ether lipid metabolism; Glycerophospholipid metabolism,Selenium Micronutrient Network; Selenium Metabolism and Selenoproteins,Synthesis of PE,10,High,1
P55157,Microsomal triglyceride transfer protein large subunit OS=Homo sapiens OX=9606 GN=MTTP PE=1 SV=1,0,25.396,6,6,30,6,894,99.3,8.41,13069,,6,,cell organization and biogenesis;metabolic process;transport,endoplasmic reticulum;organelle lumen,protein binding;transporter activity,Pf01347,4547,ENSG00000138823.13,MTTP,4,Fat digestion and absorption,Statin Pathway,VLDL assembly; Chylomicron assembly,7,High,1
Q9HCN4,GPN-loop GTPase 1 OS=Homo sapiens OX=9606 GN=GPN1 PE=1 SV=1,0,25.395,23,4,9,4,374,41.7,4.92,3643,,4,,,cytoplasm;cytosol;mitochondrion;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf01926, Pf03029, Pf12846, Pf13191, Pf13671",11321,ENSG00000198522.13,GPN1,2,,,,0,High,1
P43307,Translocon-associated protein subunit alpha OS=Homo sapiens OX=9606 GN=SSR1 PE=1 SV=3,0,25.359,17,3,57,3,286,32.2,4.49,28208,,3,,cell organization and biogenesis;regulation of biological process;transport,endoplasmic reticulum;membrane,protein binding,Pf03896,6745,ENSG00000124783.12,SSR1,6,Protein processing in endoplasmic reticulum,,XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane,7,High,1
Q9H7D7,WD repeat-containing protein 26 OS=Homo sapiens OX=9606 GN=WDR26 PE=1 SV=3,0,25.354,11,5,37,5,661,72.1,6.16,15011,,5,,,cytoplasm;cytosol,protein binding,"Pf00400, Pf08662",80232,ENSG00000162923.14,WDR26,1,,,,0,High,1
Q15751,Probable E3 ubiquitin-protein ligase HERC1 OS=Homo sapiens OX=9606 GN=HERC1 PE=1 SV=2,0,25.352,1,4,23,4,4861,531.9,6.04,11032,,4,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;Golgi;membrane,catalytic activity;protein binding,"Pf00400, Pf00415, Pf00622, Pf00632, Pf13540",8925,ENSG00000103657.13,HERC1,15,Ubiquitin mediated proteolysis,,Antigen processing: Ubiquitination & Proteasome degradation,5,High,1
P29728,2'-5'-oligoadenylate synthase 2 OS=Homo sapiens OX=9606 GN=OAS2 PE=1 SV=3,0,25.352,11,6,14,6,719,82.4,8.25,5799,,6,,defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;membrane;mitochondrion;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding,"Pf01909, Pf10421",4939,ENSG00000111335.12,OAS2,12,Herpes simplex infection; Influenza A; NOD-like receptor signaling pathway; Hepatitis C; Measles,,Interferon alpha/beta signaling; Interferon gamma signaling,10,High,1
Q96T60,Bifunctional polynucleotide phosphatase/kinase OS=Homo sapiens OX=9606 GN=PNKP PE=1 SV=1,0,25.341,17,6,24,6,521,57,8.46,8193,,6,,metabolic process;regulation of biological process;response to stimulus,membrane;mitochondrion;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding,"Pf08433, Pf08645, Pf13419, Pf13671",11284,ENSG00000039650.11,PNKP,19,,,APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway,4,High,1
Q99943,1-acyl-sn-glycerol-3-phosphate acyltransferase alpha OS=Homo sapiens OX=9606 GN=AGPAT1 PE=1 SV=2,0,25.339,13,3,39,3,283,31.7,9.38,20171,,3,,metabolic process;regulation of biological process,endoplasmic reticulum;membrane,catalytic activity;protein binding,Pf01553,10554,ENSG00000235758.9; ENSG00000228892.9; ENSG00000227642.9; ENSG00000206324.11; ENSG00000204310.12; ENSG00000236873.9; ENSG00000226467.9,AGPAT1,6; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_APD_CTG1; CHR_HSCHR6_MHC_COX_CTG1,Glycerophospholipid metabolism; Fat digestion and absorption; Glycerolipid metabolism; Metabolic pathways; Phospholipase D signaling pathway,Triacylglyceride Synthesis,Synthesis of PA; ChREBP activates metabolic gene expression,13,High,1
P15882,N-chimaerin OS=Homo sapiens OX=9606 GN=CHN1 PE=1 SV=3,0,25.318,14,5,13,5,459,53.1,6.98,5464,,5,,cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytosol,enzyme regulator activity;metal ion binding;protein binding,"Pf00017, Pf00130, Pf00620",1123,ENSG00000128656.13,CHN1,2,,,Rho GTPase cycle,3,High,1
P50135,Histamine N-methyltransferase OS=Homo sapiens OX=9606 GN=HNMT PE=1 SV=1,0,25.297,10,3,53,3,292,33.3,5.34,24816,,3,,metabolic process;response to stimulus,cytoplasm;cytosol,catalytic activity,"Pf08242, Pf13489, Pf13847",3176,ENSG00000150540.13,HNMT,2,Histidine metabolism,Amino Acid metabolism; Metapathway biotransformation; Methylation Pathways,"Metabolism of ingested SeMet, Sec, MeSec into H2Se; Histidine catabolism",10,High,1
Q9BQ39,ATP-dependent RNA helicase DDX50 OS=Homo sapiens OX=9606 GN=DDX50 PE=1 SV=1,0,25.294,12,7,20,4,737,82.5,9.17,6889,,7,,metabolic process,cytoplasm;membrane;nucleus,catalytic activity;DNA binding;nucleotide binding;RNA binding,"Pf00270, Pf00271, Pf04851, Pf08152, Pf14617",79009,ENSG00000107625.12,DDX50,10,,,,0,High,1
Q9Y4P3,Transducin beta-like protein 2 OS=Homo sapiens OX=9606 GN=TBL2 PE=1 SV=1,0,25.284,18,5,20,5,447,49.8,9.44,7518,3.68,5,1,cell communication;regulation of biological process;response to stimulus,endoplasmic reticulum,protein binding;RNA binding,Pf00400,26608,ENSG00000106638.15,TBL2,7,,,,0,High,1
Q9Y624,Junctional adhesion molecule A OS=Homo sapiens OX=9606 GN=F11R PE=1 SV=1,0,25.271,18,4,39,4,299,32.6,7.9,18743,,4,,cell differentiation;cell organization and biogenesis;cellular component movement;defense response;regulation of biological process;response to stimulus;transport,membrane,protein binding;receptor activity,"Pf00047, Pf07679, Pf07686, Pf13895, Pf13927",50848,ENSG00000158769.17,F11R,1,Epithelial cell signaling in Helicobacter pylori infection; Tight junction; Leukocyte transendothelial migration; Cell adhesion molecules (CAMs),,Integrin cell surface interactions; Tight junction interactions; Cell surface interactions at the vascular wall; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition),16,High,1
Q9BVJ7,Dual specificity protein phosphatase 23 OS=Homo sapiens OX=9606 GN=DUSP23 PE=1 SV=1,0,25.268,33,5,23,5,150,16.6,8.21,9726,,5,,metabolic process,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,"Pf00102, Pf00782, Pf03162, Pf14566",54935,ENSG00000158716.8,DUSP23,1,,,,0,High,1
P12036,Neurofilament heavy polypeptide OS=Homo sapiens OX=9606 GN=NEFH PE=1 SV=4,0,25.259,3,4,464,2,1026,112.4,6.18,255186,0,4,1,cell organization and biogenesis;regulation of biological process,cytoplasm;mitochondrion,protein binding;structural molecule activity,"Pf00038, Pf07142",4744,,NEFH,22,Amyotrophic lateral sclerosis (ALS),Amyotrophic lateral sclerosis (ALS); Association Between Physico-Chemical Features and Toxicity Associated Pathways,,3,High,1
Q96SZ5,2-aminoethanethiol dioxygenase OS=Homo sapiens OX=9606 GN=ADO PE=1 SV=2,0,25.242,22,5,33,5,270,29.7,6.04,13983,,5,,metabolic process,cytosol;mitochondrion,catalytic activity;metal ion binding,Pf07847,84890,ENSG00000181915.4,ADO,10,Metabolic pathways; Taurine and hypotaurine metabolism,,Degradation of cysteine and homocysteine,6,High,1
Q5UCC4,ER membrane protein complex subunit 10 OS=Homo sapiens OX=9606 GN=EMC10 PE=1 SV=1,0,25.196,11,3,8,3,262,27.3,6.13,4919,,3,,,extracellular;membrane,,,284361,ENSG00000161671.16,EMC10,19,,,,0,High,1
Q7Z2W4,Zinc finger CCCH-type antiviral protein 1 OS=Homo sapiens OX=9606 GN=ZC3HAV1 PE=1 SV=3,0,25.18,11,6,10,6,902,101.4,8.4,3547,,6,,defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding,Pf00644,56829,ENSG00000105939.12,ZC3HAV1,7,,,Signaling by BRAF and RAF fusions,4,High,1
Q6P996,Pyridoxal-dependent decarboxylase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PDXDC1 PE=1 SV=2,0,25.161,10,6,20,6,788,86.7,5.38,7212,,6,,metabolic process,Golgi,catalytic activity;protein binding,"Pf00282, Pf01212",23042; 102724985,ENSG00000275498.5; ENSG00000179889.18,PDXDC1; LOC102724985,16; CHR_HSCHR16_1_CTG1,,,,0,High,1
P09496,Clathrin light chain A OS=Homo sapiens OX=9606 GN=CLTA PE=1 SV=1,0,25.134,12,2,8,2,248,27.1,4.51,4955,,2,,cell division;cell organization and biogenesis;cellular component movement;metabolic process;transport,cytoplasm;cytoskeleton;cytosol;membrane,protein binding;structural molecule activity,Pf01086,1211,ENSG00000122705.16,CLTA,9,Huntington's disease; Synaptic vesicle cycle; Lysosome; Endocrine and other factor-regulated calcium reabsorption; Endocytosis; Bacterial invasion of epithelial cells,Synaptic Vesicle Pathway,"Cargo recognition for clathrin-mediated endocytosis; Formation of annular gap junctions; Golgi Associated Vesicle Biogenesis; Recycling pathway of L1; LDL clearance; Lysosome Vesicle Biogenesis; EPH-ephrin mediated repulsion of cells; Entry of Influenza Virion into Host Cell via Endocytosis; Retrograde neurotrophin signalling; VLDLR internalisation and degradation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; MHC class II antigen presentation; WNT5A-dependent internalization of FZD4",48,High,1
Q15382,GTP-binding protein Rheb OS=Homo sapiens OX=9606 GN=RHEB PE=1 SV=1,0,25.116,22,4,325,4,184,20.5,5.92,132806,2.03,4,1,regulation of biological process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;Golgi;membrane;spliceosomal complex,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00071, Pf01926, Pf08477",6009,ENSG00000106615.9,RHEB,7,Thyroid hormone signaling pathway; Longevity regulating pathway; Choline metabolism in cancer; Insulin signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Phospholipase D signaling pathway,Target Of Rapamycin (TOR) Signaling; Follicle Stimulating Hormone (FSH) signaling pathway; BDNF-TrkB Signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Angiopoietin Like Protein 8 Regulatory Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Insulin Signaling,Energy dependent regulation of mTOR by LKB1-AMPK; Regulation of PTEN gene transcription; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Macroautophagy,30,High,1
P48059-3,Isoform 3 of LIM and senescent cell antigen-like-containing domain protein 1 OS=Homo sapiens OX=9606 GN=LIMS1,0,25.084,9,4,42,4,387,44.4,8.02,20555,,4,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytosol;membrane,metal ion binding;protein binding,Pf00412,3987,ENSG00000169756.16,LIMS1,2,,Primary Focal Segmental Glomerulosclerosis FSGS,,1,High,1
Q5MNZ6,WD repeat domain phosphoinositide-interacting protein 3 OS=Homo sapiens OX=9606 GN=WDR45B PE=1 SV=2,0,25.07,15,4,16,4,344,38.1,7.59,6592,,4,,metabolic process,cytosol;membrane,protein binding,,56270,ENSG00000141580.15,WDR45B; WDR45L,17,,,Macroautophagy,2,High,1
Q9Y6A9,Signal peptidase complex subunit 1 OS=Homo sapiens OX=9606 GN=SPCS1 PE=1 SV=5,0,25.068,19,2,34,2,169,18.3,8.72,12041,,2,,metabolic process;transport,membrane,catalytic activity;protein binding,Pf06645,28972,ENSG00000114902.13,SPCS1,3,Protein export,,,1,High,1
Q13247,Serine/arginine-rich splicing factor 6 OS=Homo sapiens OX=9606 GN=SRSF6 PE=1 SV=2,0,25.057,15,6,38,4,344,39.6,11.43,17327,,6,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,nucleus,protein binding;RNA binding,"Pf00076, Pf08777, Pf13893, Pf14259",6431,ENSG00000124193.14,SRSF6,20,Spliceosome; Herpes simplex infection,mRNA Processing,Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway,15,High,1
Q8N6M0,Deubiquitinase OTUD6B OS=Homo sapiens OX=9606 GN=OTUD6B PE=1 SV=1,0,25.03,18,4,23,4,293,33.8,6.05,9001,,4,,metabolic process,,catalytic activity,"Pf02338, Pf10275",51633,ENSG00000155100.10,OTUD6B,8,,,,0,High,1
O94808,Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 OS=Homo sapiens OX=9606 GN=GFPT2 PE=1 SV=3,0,25.004,8,5,21,1,682,76.9,7.37,9461,,5,,metabolic process,cytosol,catalytic activity;protein binding,"Pf00310, Pf01380, Pf13230, Pf13522, Pf13537, Pf13580",9945,ENSG00000131459.12,GFPT2,5,"Metabolic pathways; Insulin resistance; Alanine, aspartate and glutamate metabolism; Amino sugar and nucleotide sugar metabolism",,Synthesis of UDP-N-acetyl-glucosamine,10,High,1
Q9P287,BRCA2 and CDKN1A-interacting protein OS=Homo sapiens OX=9606 GN=BCCIP PE=1 SV=1,0,24.987,25,5,26,5,314,36,4.61,9150,,5,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;nucleus,enzyme regulator activity;protein binding;RNA binding,Pf13862,56647,ENSG00000107949.16,BCCIP,10,,,,0,High,1
Q9H857,5'-nucleotidase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=NT5DC2 PE=1 SV=1,0,24.959,18,7,12,7,520,60.7,6.77,4521,,7,,metabolic process,,catalytic activity;metal ion binding;receptor activity;signal transducer activity,Pf05761,64943,ENSG00000168268.10,NT5DC2,3,,,,0,High,1
O60524,Nuclear export mediator factor NEMF OS=Homo sapiens OX=9606 GN=NEMF PE=1 SV=4,0,24.956,8,7,13,7,1076,122.9,6.35,4085,,7,,transport,nucleus,,"Pf05670, Pf05833, Pf11923",9147,ENSG00000165525.17,NEMF,14,,,,0,High,1
Q9Y282,Endoplasmic reticulum-Golgi intermediate compartment protein 3 OS=Homo sapiens OX=9606 GN=ERGIC3 PE=1 SV=1,0,24.909,10,5,29,5,383,43.2,6.06,10829,0,5,1,transport,endoplasmic reticulum;Golgi;membrane,,"Pf07970, Pf13850",51614,ENSG00000125991.19,ERGIC3,20,,,,0,High,1
Q92609,TBC1 domain family member 5 OS=Homo sapiens OX=9606 GN=TBC1D5 PE=1 SV=1,0,24.902,12,6,10,6,795,88.9,6.54,3161,,6,,cell communication;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;endosome;Golgi;membrane;vacuole,enzyme regulator activity;protein binding,Pf00566,9779,ENSG00000131374.14,TBC1D5,3,,,,0,High,1
A6ZKI3,Retrotransposon Gag-like protein 8C OS=Homo sapiens OX=9606 GN=RTL8C PE=1 SV=1,0,24.89,35,5,51,5,113,13.2,5.07,24316,,5,,,,protein binding,,8933,ENSG00000134590.13,FAM127A; RTL8C,X,,,,0,High,1
Q6PK18,2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3 OS=Homo sapiens OX=9606 GN=OGFOD3 PE=1 SV=2,0,24.89,13,4,16,4,319,35.6,8.18,6209,,4,,metabolic process,membrane,catalytic activity;metal ion binding,Pf13640,79701,ENSG00000181396.12,OGFOD3,17,,,,0,High,1
Q8WXI9,Transcriptional repressor p66-beta OS=Homo sapiens OX=9606 GN=GATAD2B PE=1 SV=1,0,24.884,13,6,18,5,593,65.2,9.7,8385,,6,,cell organization and biogenesis;metabolic process;regulation of biological process,nucleus,DNA binding;metal ion binding;protein binding,"Pf00320, Pf00412",57459,ENSG00000261992.2; ENSG00000143614.9,GATAD2B,1; CHR_HSCHR1_1_CTG31,,,ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation,20,High,1
Q96HJ9,Protein FMC1 homolog OS=Homo sapiens OX=9606 GN=FMC1 PE=1 SV=2,0,24.872,30,3,111,3,113,12.7,10.07,50455,,3,,regulation of biological process,mitochondrion,,Pf13233,154791; 100996928,ENSG00000164898.12,C7orf55; FMC1; C7orf55-LUC7L2,7,,,,0,High,1
O95825,Quinone oxidoreductase-like protein 1 OS=Homo sapiens OX=9606 GN=CRYZL1 PE=1 SV=2,0,24.862,19,4,17,4,349,38.7,5.78,7481,,4,,metabolic process,cytosol,catalytic activity;nucleotide binding,Pf00107,9946,ENSG00000205758.11,CRYZL1,21,,,,0,High,1
Q86VX2,COMM domain-containing protein 7 OS=Homo sapiens OX=9606 GN=COMMD7 PE=1 SV=2,0,24.855,20,3,28,3,200,22.5,5.92,8603,0,3,1,metabolic process;regulation of biological process;response to stimulus,,protein binding,Pf07258,149951,ENSG00000149600.11,COMMD7,20,,,Neddylation,3,High,1
P49757,Protein numb homolog OS=Homo sapiens OX=9606 GN=NUMB PE=1 SV=2,0,24.848,16,7,37,7,651,70.8,8.51,9290,,7,,cell differentiation;cell division;cell organization and biogenesis;cell proliferation;development;regulation of biological process,cytoplasm;endosome;membrane;nucleus,protein binding,"Pf00640, Pf06311, Pf08416",8650,ENSG00000133961.19,NUMB,14,Notch signaling pathway,Notch Signaling Pathway; Notch Signaling Pathway,Hedgehog 'on' state; Activated NOTCH1 Transmits Signal to the Nucleus; Degradation of GLI1 by the proteasome; Recycling pathway of L1,15,High,1
Q9Y5S9,RNA-binding protein 8A OS=Homo sapiens OX=9606 GN=RBM8A PE=1 SV=1,0,24.842,34,4,25,4,174,19.9,5.72,11047,,4,,metabolic process;regulation of biological process;transport,cytoplasm;cytosol;nucleus;spliceosomal complex,protein binding;RNA binding,"Pf00076, Pf08777, Pf13893, Pf14259",9939,ENSG00000265241.6,RBM8A; LOC101060541,1,RNA transport; Spliceosome; mRNA surveillance pathway,,mRNA 3'-end processing; mRNA Splicing - Major Pathway; Cleavage of Growing Transcript in the Termination Region ; Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC),20,High,1
Q99543,DnaJ homolog subfamily C member 2 OS=Homo sapiens OX=9606 GN=DNAJC2 PE=1 SV=4,0,24.832,10,6,17,6,621,72,8.7,7617,,6,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;nucleus,DNA binding;enzyme regulator activity;protein binding;RNA binding,"Pf00226, Pf00249",27000,ENSG00000105821.14,DNAJC2,7,,,Regulation of HSF1-mediated heat shock response,4,High,1
O60613,Selenoprotein F OS=Homo sapiens OX=9606 GN=SELENOF PE=1 SV=4,0,24.822,23,3,48,3,165,18.1,5.03,22297,,3,,,,,,,,,,,,,0,High,1
P49916,DNA ligase 3 OS=Homo sapiens OX=9606 GN=LIG3 PE=1 SV=2,0,24.778,7,6,26,6,1009,112.8,9.01,13547,,6,,cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,mitochondrion;nucleus,catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding,"Pf00645, Pf01068, Pf04675, Pf04679",3980,ENSG00000005156.11,LIG3,17,Base excision repair,,Resolution of AP sites via the single-nucleotide replacement pathway; Gap-filling DNA repair synthesis and ligation in TC-NER; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; HDR through MMEJ (alt-NHEJ); Gap-filling DNA repair synthesis and ligation in GG-NER,14,High,1
Q08170,Serine/arginine-rich splicing factor 4 OS=Homo sapiens OX=9606 GN=SRSF4 PE=1 SV=2,0,24.749,10,4,20,2,494,56.6,11.52,11016,,4,,metabolic process;regulation of biological process;response to stimulus;transport,nucleus,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",6429,ENSG00000116350.16,SRSF4,1,Herpes simplex infection; Spliceosome,mRNA Processing,Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway,14,High,1
Q9BUQ8,Probable ATP-dependent RNA helicase DDX23 OS=Homo sapiens OX=9606 GN=DDX23 PE=1 SV=3,0,24.709,7,5,30,5,820,95.5,9.55,12802,,5,,cell organization and biogenesis;metabolic process,cytoplasm;nucleus;spliceosomal complex,catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding,"Pf00270, Pf00271, Pf04851",9416,ENSG00000174243.9,DDX23,12,Spliceosome,,mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway,6,High,1
O60861-1,Isoform 1 of Growth arrest-specific protein 7 OS=Homo sapiens OX=9606 GN=GAS7,0,24.685,19,5,13,5,412,47.2,7.58,4773,,5,,cell differentiation;regulation of biological process,cytoplasm,protein binding,"Pf00397, Pf00611, Pf04012, Pf10186",8522,ENSG00000007237.18,GAS7,17,,,,0,High,1
Q96MG8,Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PCMTD1 PE=1 SV=2,0,24.681,11,3,23,3,357,40.7,5.66,9600,0,3,1,metabolic process,cytoplasm;membrane,catalytic activity,"Pf01135, Pf12847, Pf13847",115294,ENSG00000168300.13,PCMTD1,8,,,,0,High,1
Q96KR1,Zinc finger RNA-binding protein OS=Homo sapiens OX=9606 GN=ZFR PE=1 SV=2,0,24.673,6,5,19,5,1074,116.9,9.04,7739,,5,,development,chromosome;cytoplasm;nucleus,DNA binding;metal ion binding;protein binding;RNA binding,"Pf07528, Pf12171, Pf12874",51663,ENSG00000056097.15,ZFR,5,,Exercise-induced Circadian Regulation,,1,High,1
Q5VU43,Myomegalin OS=Homo sapiens OX=9606 GN=PDE4DIP PE=1 SV=3,0,24.671,3,6,21,6,2346,264.9,5.47,6751,,6,,,,,,,,,,,,,0,High,1
Q8NAT1,"Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 OS=Homo sapiens OX=9606 GN=POMGNT2 PE=1 SV=1",0,24.668,13,6,18,6,580,66.6,8.57,6823,0,6,1,cellular component movement;metabolic process,endoplasmic reticulum;membrane,catalytic activity;protein binding,Pf04577,84892,ENSG00000144647.5,GTDC2; POMGNT2,3,,,O-linked glycosylation,3,High,1
Q9Y3M8,StAR-related lipid transfer protein 13 OS=Homo sapiens OX=9606 GN=STARD13 PE=1 SV=2,0,24.655,7,6,11,6,1113,124.9,7.02,4005,,6,,cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;mitochondrion,enzyme regulator activity;protein binding,"Pf00620, Pf01852, Pf07647",90627,ENSG00000133121.20,STARD13,13,,,Rho GTPase cycle,3,High,1
O96011,Peroxisomal membrane protein 11B OS=Homo sapiens OX=9606 GN=PEX11B PE=1 SV=1,0,24.637,19,5,21,5,259,28.4,9.85,8678,,5,,cell organization and biogenesis;regulation of biological process;response to stimulus,membrane,protein binding,Pf05648,8799,ENSG00000131779.10,LOC101060567; PEX11B,1,Peroxisome,,,1,High,1
O15160,DNA-directed RNA polymerases I and III subunit RPAC1 OS=Homo sapiens OX=9606 GN=POLR1C PE=1 SV=1,0,24.636,21,6,18,6,346,39.2,5.5,6349,,6,,metabolic process;regulation of biological process,cytosol;nucleus,catalytic activity;DNA binding;protein binding,"Pf01000, Pf01193",9533,ENSG00000171453.17,POLR1C,6,RNA polymerase; Pyrimidine metabolism; Purine metabolism; Metabolic pathways; Cytosolic DNA-sensing pathway; Epstein-Barr virus infection,,RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination; RNA Polymerase I Transcription Termination; RNA Polymerase I Chain Elongation; NoRC negatively regulates rRNA expression; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase I Promoter Escape; B-WICH complex positively regulates rRNA expression; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase III Transcription Initiation From Type 2 Promoter,29,High,1
Q9UII6,Dual specificity protein phosphatase 13 isoform B OS=Homo sapiens OX=9606 GN=DUSP13 PE=1 SV=3,0,24.62,30,3,14,3,198,22.1,9.14,,40.06,,3,metabolic process,,catalytic activity;protein binding,"Pf00102, Pf00782",51207,ENSG00000079393.20,DUSP13,10,,,,0,High,1
P26678,Cardiac phospholamban OS=Homo sapiens OX=9606 GN=PLN PE=1 SV=1,0,24.612,23,2,72,2,52,6.1,9.28,31711,,2,,cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;membrane;mitochondrion,enzyme regulator activity;protein binding,Pf04272,5350,ENSG00000198523.5,PLN,6,Calcium signaling pathway; Thyroid hormone signaling pathway; cAMP signaling pathway; cGMP-PKG signaling pathway; Adrenergic signaling in cardiomyocytes; Dilated cardiomyopathy,Calcium Regulation in the Cardiac Cell,Ion homeostasis; Ion transport by P-type ATPases,13,High,1
P42336,"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform OS=Homo sapiens OX=9606 GN=PIK3CA PE=1 SV=2",0,24.609,7,6,32,6,1068,124.2,7.23,11411,,6,,cell death;cellular component movement;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding,"Pf00454, Pf00613, Pf00792, Pf00794, Pf02192",5290,ENSG00000121879.3,PIK3CA,3,Longevity regulating pathway - multiple species; Epstein-Barr virus infection; Prostate cancer; Choline metabolism in cancer; Ras signaling pathway; MicroRNAs in cancer; Type II diabetes mellitus; Apoptosis; Toll-like receptor signaling pathway; Longevity regulating pathway; HIF-1 signaling pathway; Progesterone-mediated oocyte maturation; Inositol phosphate metabolism; Non-alcoholic fatty liver disease (NAFLD); Influenza A; TNF signaling pathway; VEGF signaling pathway; Phosphatidylinositol signaling system; Aldosterone-regulated sodium reabsorption; Chemokine signaling pathway; Viral carcinogenesis; cGMP-PKG signaling pathway; ErbB signaling pathway; Jak-STAT signaling pathway; Inflammatory mediator regulation of TRP channels; Platelet activation; FoxO signaling pathway; Breast cancer; HTLV-I infection; Measles; Insulin resistance; Hepatitis B; Rap1 signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Regulation of actin cytoskeleton; Signaling pathways regulating pluripotency of stem cells; Amoebiasis; Neurotrophin signaling pathway; Thyroid hormone signaling pathway; AMPK signaling pathway; Fc gamma R-mediated phagocytosis; Central carbon metabolism in cancer; Oxytocin signaling pathway; Melanoma; Sphingolipid signaling pathway; Estrogen signaling pathway; Chagas disease (American trypanosomiasis); Chronic myeloid leukemia; Pathways in cancer; Proteoglycans in cancer; Hepatitis C; Platinum drug resistance; Insulin signaling pathway; Non-small cell lung cancer; Renal cell carcinoma; Leukocyte transendothelial migration; cAMP signaling pathway; Phospholipase D signaling pathway; Natural killer cell mediated cytotoxicity; Focal adhesion; Fc epsilon RI signaling pathway; PI3K-Akt signaling pathway; Osteoclast differentiation; Acute myeloid leukemia; Adrenergic signaling in cardiomyocytes; Carbohydrate digestion and absorption; Axon guidance; Prolactin signaling pathway; Colorectal cancer; Toxoplasmosis; Small cell lung cancer; Cholinergic synapse; T cell receptor signaling pathway; B cell receptor signaling pathway; Glioma; mTOR signaling pathway; Endocrine resistance; Pancreatic cancer; Endometrial cancer; EGFR tyrosine kinase inhibitor resistance; Bacterial invasion of epithelial cells; Regulation of lipolysis in adipocytes,AMP-activated Protein Kinase (AMPK) Signaling; Regulation of toll-like receptor signaling pathway; Angiogenesis; MicroRNAs in cardiomyocyte hypertrophy; Sterol Regulatory Element-Binding Proteins (SREBP) signalling; Human Thyroid Stimulating Hormone (TSH) signaling pathway; Prolactin Signaling Pathway; Regulation of Microtubule Cytoskeleton; Signaling Pathways in Glioblastoma; IL1 and megakaryocytes in obesity; Transcriptional activation by NRF2; Focal Adhesion; Signaling of Hepatocyte Growth Factor Receptor; Copper homeostasis; Rac1/Pak1/p38/MMP-2 pathway; Pathways Affected in Adenoid Cystic Carcinoma; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; Chemokine signaling pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Microglia Pathogen Phagocytosis Pathway; IL-4 Signaling Pathway; Insulin Signaling; Regulation of Actin Cytoskeleton; G13 Signaling Pathway; DNA Damage Response (only ATM dependent); Estrogen signaling pathway; Toll-like receptor signaling pathway,"PI3K Cascade; Signaling by FGFR4 in disease; Downstream TCR signaling; PI-3K cascade:FGFR3; PI3K events in ERBB4 signaling; DAP12 signaling; PI-3K cascade:FGFR4; Regulation of signaling by CBL; Signaling by cytosolic FGFR1 fusion mutants; MET activates PI3K/AKT signaling; Role of phospholipids in phagocytosis; G alpha (12/13) signalling events; Constitutive Signaling by EGFRvIII; VEGFA-VEGFR2 Pathway; Interleukin receptor SHC signaling; GPVI-mediated activation cascade; CD28 dependent PI3K/Akt signaling; PI-3K cascade:FGFR2; RET signaling; Synthesis of PIPs at the plasma membrane; PI3K events in ERBB2 signaling; PI-3K cascade:FGFR1; Role of LAT2/NTAL/LAB on calcium mobilization; Tie2 Signaling; Signaling by FGFR2 in disease; Signaling by FGFR3 fusions in cancer; G beta:gamma signalling through PI3Kgamma; Interleukin-7 signaling; Downstream signal transduction; Signaling by FGFR3 point mutants in cancer; PI3K/AKT activation; Nephrin family interactions; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Gastrin-CREB signalling pathway via PKC and MAPK; Signaling by SCF-KIT; GAB1 signalosome",215,High,1
P07196,Neurofilament light polypeptide OS=Homo sapiens OX=9606 GN=NEFL PE=1 SV=3,0,24.549,4,4,464,2,543,61.5,4.65,256193,0,4,1,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol,catalytic activity;motor activity;protein binding;structural molecule activity,"Pf00038, Pf01576, Pf07889",4747,ENSG00000277586.2,NEFL,8,Amyotrophic lateral sclerosis (ALS),Amyotrophic lateral sclerosis (ALS); Association Between Physico-Chemical Features and Toxicity Associated Pathways,"Ras activation uopn Ca2+ infux through NMDA receptor; Unblocking of NMDA receptor, glutamate binding and activation; RAF/MAP kinase cascade; CREB phosphorylation through the activation of CaMKII; Interleukin-20 family signaling",20,High,1
Q9NXH8,Torsin-4A OS=Homo sapiens OX=9606 GN=TOR4A PE=1 SV=2,0,24.545,17,6,19,6,423,46.9,9.94,7545,,6,,transport,extracellular;membrane;organelle lumen,nucleotide binding,"Pf06309, Pf13191, Pf13207, Pf13238",54863,ENSG00000198113.2,TOR4A,9,,,Platelet degranulation,4,High,1
P28676,Grancalcin OS=Homo sapiens OX=9606 GN=GCA PE=1 SV=2,0,24.543,28,5,23,5,217,24,5.21,10684,,5,,cell organization and biogenesis;metabolic process;transport,cytoplasm;cytosol;extracellular;membrane;organelle lumen,catalytic activity;metal ion binding;protein binding,"Pf13499, Pf13833",25801,ENSG00000115271.10,GCA,2,,,Neutrophil degranulation,3,High,1
Q96C90,Protein phosphatase 1 regulatory subunit 14B OS=Homo sapiens OX=9606 GN=PPP1R14B PE=1 SV=3,0,24.54,44,3,9,3,147,15.9,4.86,5218,,3,,defense response;regulation of biological process;response to stimulus,cytoplasm,enzyme regulator activity,Pf05361,26472,ENSG00000173457.10,PPP1R14B,11,,,,0,High,1
Q9NX55,Huntingtin-interacting protein K OS=Homo sapiens OX=9606 GN=HYPK PE=1 SV=2,0,24.536,32,4,23,4,129,14.7,4.93,10543,,4,,regulation of biological process,cytoplasm;cytoskeleton;nucleus,protein binding,,25764,ENSG00000242028.6,HYPK,15,,,,0,High,1
P19388,"DNA-directed RNA polymerases I, II, and III subunit RPABC1 OS=Homo sapiens OX=9606 GN=POLR2E PE=1 SV=4",0,24.479,37,5,27,5,210,24.5,5.95,12593,,5,,metabolic process;regulation of biological process;response to stimulus,cytosol;nucleus,catalytic activity;DNA binding;protein binding,"Pf01191, Pf03871",5434,ENSG00000099817.11,POLR2E,19,Purine metabolism; Cytosolic DNA-sensing pathway; RNA polymerase; Epstein-Barr virus infection; Metabolic pathways; Huntington's disease; Pyrimidine metabolism,Eukaryotic Transcription Initiation,Signaling by FGFR2 IIIa TM; RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Tat-mediated HIV elongation arrest and recovery; NoRC negatively regulates rRNA expression; Formation of HIV-1 elongation complex containing HIV-1 Tat; MicroRNA (miRNA) biogenesis; RNA Polymerase III Transcription Termination; Formation of the HIV-1 Early Elongation Complex; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; TP53 Regulates Transcription of DNA Repair Genes; Transcriptional regulation by small RNAs; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; RNA Polymerase II HIV Promoter Escape; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase III Chain Elongation; Transcriptional regulation of pluripotent stem cells; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase I Chain Elongation; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; Formation of TC-NER Pre-Incision Complex; Pausing and recovery of HIV elongation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase I Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase III Abortive And Retractive Initiation; HIV elongation arrest and recovery; RNA Pol II CTD phosphorylation and interaction with CE; Viral Messenger RNA Synthesis; RNA Polymerase I Transcription Termination; RNA Polymerase II Transcription Initiation; mRNA Capping; Dual incision in TC-NER; PIWI-interacting RNA (piRNA) biogenesis; RNA Polymerase III Transcription Initiation From Type 1 Promoter; B-WICH complex positively regulates rRNA expression; Cytosolic sensors of pathogen-associated DNA ; Pausing and recovery of Tat-mediated HIV elongation; RNA Polymerase I Transcription Initiation; Formation of the Early Elongation Complex; RNA Polymerase III Transcription Initiation From Type 2 Promoter,98,High,1
P01700,Immunoglobulin lambda variable 1-47 OS=Homo sapiens OX=9606 GN=IGLV1-47 PE=1 SV=2,0,24.449,38,5,43,5,117,12.3,5.91,20177,1.94,5,1,cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity;protein binding,Pf07686,28822,ENSG00000211648.2,IGLV1-47,22,,,FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis,26,High,1
P08246,Neutrophil elastase OS=Homo sapiens OX=9606 GN=ELANE PE=1 SV=1,0,24.44,6,4,45,4,267,28.5,9.35,22669,,4,,cell organization and biogenesis;cellular component movement;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;extracellular;organelle lumen,catalytic activity;protein binding,"Pf00089, Pf09342",1991,ENSG00000277571.2; ENSG00000197561.6,ELANE,19; CHR_HSCHR19_5_CTG2,Transcriptional misregulation in cancer; Systemic lupus erythematosus,,Collagen degradation; Activation of Matrix Metalloproteinases; Antimicrobial peptides; Regulation of Complement cascade; Neutrophil degranulation,12,High,1
Q5HYK7,SH3 domain-containing protein 19 OS=Homo sapiens OX=9606 GN=SH3D19 PE=1 SV=2,0,24.376,8,6,16,6,790,86.5,8.32,8098,,6,,cell organization and biogenesis;regulation of biological process,cytoplasm;cytosol;membrane;nucleus,protein binding,"Pf00018, Pf07653, Pf14604",152503,ENSG00000109686.17,SH3D19,4,,,Golgi Associated Vesicle Biogenesis,5,High,1
Q8N699,Myc target protein 1 OS=Homo sapiens OX=9606 GN=MYCT1 PE=1 SV=1,0,24.361,22,4,25,4,235,26.6,9.83,12779,,4,,,nucleus,,Pf15179,80177,ENSG00000120279.6,MYCT1,6,,,,0,High,1
Q9H1K0,Rabenosyn-5 OS=Homo sapiens OX=9606 GN=RBSN PE=1 SV=2,0,24.351,7,4,17,4,784,88.8,5.5,7454,,4,,cell organization and biogenesis;coagulation;metabolic process;regulation of biological process;transport,cytosol;endosome;membrane,metal ion binding;protein binding,"Pf01155, Pf01363, Pf11464",64145,ENSG00000131381.12,ZFYVE20; RBSN,3,Endocytosis,,Factors involved in megakaryocyte development and platelet production; Toll Like Receptor 9 (TLR9) Cascade,7,High,1
Q9P0L2,Serine/threonine-protein kinase MARK1 OS=Homo sapiens OX=9606 GN=MARK1 PE=1 SV=2,0,24.336,8,7,44,2,795,88.9,9.36,15638,,7,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;membrane,catalytic activity;metal ion binding;nucleotide binding,"Pf00069, Pf00627, Pf02149, Pf07714, Pf14531",4139,ENSG00000116141.15,MARK1,1,,Regulation of Microtubule Cytoskeleton,,1,High,1
Q13523,Serine/threonine-protein kinase PRP4 homolog OS=Homo sapiens OX=9606 GN=PRPF4B PE=1 SV=3,0,24.328,8,7,16,7,1007,116.9,10.26,5540,,7,,metabolic process,chromosome;nucleus;spliceosomal complex,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00069, Pf07714",8899,ENSG00000112739.16,PRPF4B,6,,mRNA Processing,,1,High,1
Q8N568,Serine/threonine-protein kinase DCLK2 OS=Homo sapiens OX=9606 GN=DCLK2 PE=1 SV=4,0,24.327,9,5,14,5,766,83.6,8.34,6242,,5,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton,catalytic activity;nucleotide binding,"Pf00069, Pf03607, Pf07714, Pf14531",166614,ENSG00000170390.15,DCLK2,4,,,,0,High,1
P62857,40S ribosomal protein S28 OS=Homo sapiens OX=9606 GN=RPS28 PE=1 SV=1,0,24.32,36,3,70,3,69,7.8,10.7,36626,,3,,cell organization and biogenesis;metabolic process;transport,cytosol;ribosome,protein binding;RNA binding;structural molecule activity,Pf01200,6234,ENSG00000233927.4,RPS28,19,Ribosome,Cytoplasmic Ribosomal Proteins,"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane",38,High,1
Q96IY4,Carboxypeptidase B2 OS=Homo sapiens OX=9606 GN=CPB2 PE=1 SV=2,0,24.319,11,5,42,5,423,48.4,7.71,18469,0,5,1,cellular homeostasis;coagulation;metabolic process;regulation of biological process;response to stimulus,extracellular,catalytic activity;metal ion binding,"Pf00246, Pf02244",1361,ENSG00000080618.13,CPB2,13,Pancreatic secretion; Complement and coagulation cascades; Protein digestion and absorption,Complement and Coagulation Cascades,Metabolism of Angiotensinogen to Angiotensins; Regulation of Complement cascade,11,High,1
P33240,Cleavage stimulation factor subunit 2 OS=Homo sapiens OX=9606 GN=CSTF2 PE=1 SV=1,0,24.3,20,5,26,4,577,60.9,6.83,7048,,5,,metabolic process,nucleus,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259, Pf14304, Pf14327",1478,ENSG00000101811.13,CSTF2,X,mRNA surveillance pathway,mRNA Processing,Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs; mRNA 3'-end processing; mRNA Splicing - Major Pathway; tRNA processing in the nucleus,15,High,1
Q9Y4D7,Plexin-D1 OS=Homo sapiens OX=9606 GN=PLXND1 PE=1 SV=3,0,24.285,5,6,22,5,1925,211.9,7.15,9887,,6,,cell organization and biogenesis;cellular component movement;development;regulation of biological process;response to stimulus,membrane,protein binding;receptor activity;signal transducer activity,"Pf01403, Pf01437, Pf01833, Pf08337",23129,ENSG00000004399.12,PLXND1,3,,,Other semaphorin interactions,4,High,1
Q9Y2B0,Protein canopy homolog 2 OS=Homo sapiens OX=9606 GN=CNPY2 PE=1 SV=1,0,24.272,21,3,28,3,182,20.6,4.92,12528,1.7,3,1,regulation of biological process;response to stimulus,endoplasmic reticulum,protein binding,Pf11938,10330,ENSG00000257727.5,CNPY2,12,,,,0,High,1
P14621,Acylphosphatase-2 OS=Homo sapiens OX=9606 GN=ACYP2 PE=1 SV=2,0,24.27,40,5,111,5,99,11.1,9.5,48254,0,5,2,metabolic process,,catalytic activity;protein binding,Pf00708,98,ENSG00000170634.12,ACYP2,2,Pyruvate metabolism,,,1,High,1
Q9BYM8,RanBP-type and C3HC4-type zinc finger-containing protein 1 OS=Homo sapiens OX=9606 GN=RBCK1 PE=1 SV=2,0,24.27,14,6,14,6,510,57.5,5.67,5382,,6,,metabolic process;regulation of biological process;response to stimulus,cytosol,catalytic activity;metal ion binding;protein binding,"Pf01485, Pf07130, Pf13639",10616,ENSG00000125826.20,RBCK1,20,NOD-like receptor signaling pathway,Regulation of toll-like receptor signaling pathway,Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; Antigen processing: Ubiquitination & Proteasome degradation,11,High,1
P98175,RNA-binding protein 10 OS=Homo sapiens OX=9606 GN=RBM10 PE=1 SV=3,0,24.262,9,5,11,5,930,103.5,5.97,4661,,5,,metabolic process;regulation of biological process,nucleus,metal ion binding;protein binding;RNA binding,"Pf00076, Pf00641, Pf01585, Pf12656, Pf14259",8241,ENSG00000182872.15,RBM10,X,,,,0,High,1
O75648,Mitochondrial tRNA-specific 2-thiouridylase 1 OS=Homo sapiens OX=9606 GN=TRMU PE=1 SV=2,0,24.254,15,5,19,5,421,47.7,8.03,7313,1.78,5,1,cell organization and biogenesis;metabolic process,mitochondrion,catalytic activity;nucleotide binding;RNA binding,"Pf00733, Pf02540, Pf02568, Pf03054",55687,ENSG00000100416.12,TRMU,22,Sulfur relay system,,tRNA modification in the mitochondrion,4,High,1
O00541,Pescadillo homolog OS=Homo sapiens OX=9606 GN=PES1 PE=1 SV=1,0,24.243,8,4,24,4,588,68,7.33,9583,,4,,cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process,chromosome;cytosol;membrane;nucleus,protein binding;RNA binding,"Pf00533, Pf06732",23481,ENSG00000100029.17,PES1,22,,,Major pathway of rRNA processing in the nucleolus and cytosol,4,High,1
P00846,ATP synthase subunit a OS=Homo sapiens OX=9606 GN=MT-ATP6 PE=1 SV=1,0,24.243,10,3,342,3,226,24.8,10.1,163914,,3,,cell organization and biogenesis;metabolic process;response to stimulus;transport,membrane;mitochondrion,catalytic activity;transporter activity,Pf00119,4508,ENSG00000198899.2,ATP6,MT,Parkinson's disease; Alzheimer's disease; Huntington's disease; Metabolic pathways; Oxidative phosphorylation,Electron Transport Chain; Oxidative phosphorylation,Cristae formation; Formation of ATP by chemiosmotic coupling,14,High,1
Q9NZT2,Opioid growth factor receptor OS=Homo sapiens OX=9606 GN=OGFR PE=1 SV=3,0,24.235,9,5,13,5,677,73.3,4.84,4988,,5,,regulation of biological process;response to stimulus,cytoplasm;extracellular;membrane;nucleus,protein binding;receptor activity;signal transducer activity,"Pf04652, Pf04664, Pf05518, Pf05616, Pf05887, Pf06333, Pf07174, Pf09786, Pf12238, Pf15279, Pf15325",11054,ENSG00000060491.16,OGFR,20,,,,0,High,1
Q9BVG9,Phosphatidylserine synthase 2 OS=Homo sapiens OX=9606 GN=PTDSS2 PE=1 SV=1,0,24.219,17,6,17,6,487,56.2,6.25,5657,0,6,1,metabolic process,endoplasmic reticulum;membrane,catalytic activity,Pf03034,81490,ENSG00000174915.11,PTDSS2,11,Metabolic pathways; Glycerophospholipid metabolism,Kennedy pathway,Synthesis of PS,8,High,1
Q9BYI3,Hyccin OS=Homo sapiens OX=9606 GN=FAM126A PE=1 SV=2,0,24.216,14,5,23,5,521,57.6,8.16,8671,,5,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,protein binding;signal transducer activity,Pf09790,84668,ENSG00000122591.11,FAM126A,7,,,,0,High,1
Q9HD23,"Magnesium transporter MRS2 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=MRS2 PE=1 SV=1",0,24.211,16,6,28,6,443,50.3,6.87,10045,,6,,metabolic process;transport,membrane;mitochondrion,transporter activity,,57380,ENSG00000124532.14,MRS2,6,,,Miscellaneous transport and binding events,2,High,1
P02745,Complement C1q subcomponent subunit A OS=Homo sapiens OX=9606 GN=C1QA PE=1 SV=2,0,24.211,13,3,57,3,245,26,9.11,22487,9.19,3,1,cell communication;defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,catalytic activity;protein binding,"Pf00229, Pf00386, Pf01391",712,ENSG00000173372.16,C1QA,1,Prion diseases; Staphylococcus aureus infection; Pertussis; Systemic lupus erythematosus; Complement and coagulation cascades; Chagas disease (American trypanosomiasis),Allograft Rejection; Microglia Pathogen Phagocytosis Pathway; Oxidative Damage; Complement Activation; Complement and Coagulation Cascades,Regulation of Complement cascade; Classical antibody-mediated complement activation,18,High,1
Q96M96,"FYVE, RhoGEF and PH domain-containing protein 4 OS=Homo sapiens OX=9606 GN=FGD4 PE=1 SV=2",0,24.196,12,6,22,6,766,86.6,6.13,7058,,6,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;Golgi,metal ion binding;protein binding,"Pf00169, Pf00621, Pf01363",121512,ENSG00000139132.14,FGD4,12,,,G alpha (12/13) signalling events; NRAGE signals death through JNK; Signalling by NGF; Rho GTPase cycle,11,High,1
Q13393,Phospholipase D1 OS=Homo sapiens OX=9606 GN=PLD1 PE=1 SV=1,0,24.17,9,7,17,7,1074,124.1,8.78,5501,,7,,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;endosome;Golgi;membrane,catalytic activity;protein binding,"Pf00169, Pf00614, Pf00787, Pf13091",5337,ENSG00000075651.15,PLD1,3,Metabolic pathways; Sphingolipid signaling pathway; Pancreatic cancer; Fc gamma R-mediated phagocytosis; Pathways in cancer; Ether lipid metabolism; Glycerophospholipid metabolism; Choline metabolism in cancer; cAMP signaling pathway; Phospholipase D signaling pathway; GnRH signaling pathway; Glutamatergic synapse; Ras signaling pathway; Endocytosis,Human Thyroid Stimulating Hormone (TSH) signaling pathway; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; One carbon metabolism and related pathways; EGF/EGFR Signaling Pathway,Synthesis of PG; Synthesis of PA; Neutrophil degranulation; Role of phospholipids in phagocytosis,29,High,1
Q9UBH6,Xenotropic and polytropic retrovirus receptor 1 OS=Homo sapiens OX=9606 GN=XPR1 PE=1 SV=1,0,24.146,6,4,24,4,696,81.5,8.44,7930,,4,,cellular homeostasis;regulation of biological process;response to stimulus;transport,cytoplasm;membrane,receptor activity;signal transducer activity;transporter activity,"Pf03105, Pf03124",9213,ENSG00000143324.13,XPR1,1,,,,0,High,1
Q9HAN9,Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 OS=Homo sapiens OX=9606 GN=NMNAT1 PE=1 SV=1,0,24.138,23,5,17,5,279,31.9,8.87,6216,,5,,metabolic process;response to stimulus,nucleus,catalytic activity;nucleotide binding;protein binding,Pf01467,64802,ENSG00000173614.13,NMNAT1,1,Metabolic pathways; Nicotinate and nicotinamide metabolism,NAD Biosynthesis II (from tryptophan); NAD+ metabolism; NAD+ biosynthetic pathways,Nicotinate metabolism,9,High,1
O75882,Attractin OS=Homo sapiens OX=9606 GN=ATRN PE=1 SV=2,0,24.1,4,4,21,4,1429,158.4,7.31,9880,,4,,defense response;regulation of biological process;response to stimulus,cytoplasm;extracellular;membrane,protein binding;receptor activity,"Pf00059, Pf00431, Pf01344, Pf01437, Pf13418, Pf13854",8455,ENSG00000088812.17,ATRN,20,,,,0,High,1
Q9NV96,Cell cycle control protein 50A OS=Homo sapiens OX=9606 GN=TMEM30A PE=1 SV=1,0,24.095,19,5,23,5,361,40.7,8.59,8069,,5,,cell organization and biogenesis;regulation of biological process;transport,endoplasmic reticulum;Golgi;membrane,protein binding;transporter activity,Pf03381,55754,ENSG00000112697.15,TMEM30A,6,,,Neutrophil degranulation,3,High,1
Q9BUP3,Oxidoreductase HTATIP2 OS=Homo sapiens OX=9606 GN=HTATIP2 PE=1 SV=2,0,24.094,26,7,23,7,242,27,8.38,5984,0,6,1,cell death;cell differentiation;development;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf01118, Pf03435, Pf13460",10553,ENSG00000109854.13,HTATIP2,11,,,,0,High,1
Q8NI27,THO complex subunit 2 OS=Homo sapiens OX=9606 GN=THOC2 PE=1 SV=2,0,24.092,5,6,16,6,1593,182.7,8.44,7134,,6,,cell differentiation;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;transport,nucleus,protein binding;RNA binding,"Pf11262, Pf11732",57187,ENSG00000125676.19,THOC2,X,RNA transport; Spliceosome,,Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing,11,High,1
Q7Z6K5,Arpin OS=Homo sapiens OX=9606 GN=ARPIN PE=1 SV=1,0,24.08,28,4,20,4,226,24.9,5.83,6776,0,4,1,regulation of biological process,,protein binding,Pf10574,348110,ENSG00000242498.7,C15orf38; ARPIN,15,,,,0,High,1
Q9H5N1,Rab GTPase-binding effector protein 2 OS=Homo sapiens OX=9606 GN=RABEP2 PE=1 SV=2,0,24.063,11,5,16,5,569,63.5,4.78,5759,2.25,5,1,regulation of biological process;transport,cytoplasm;cytosol;endosome,enzyme regulator activity;protein binding,"Pf03528, Pf09311",79874,ENSG00000177548.12,RABEP2,16,,,,0,High,1
Q05209,Tyrosine-protein phosphatase non-receptor type 12 OS=Homo sapiens OX=9606 GN=PTPN12 PE=1 SV=3,0,24.052,8,5,19,5,780,88.1,5.62,9191,,5,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,catalytic activity;DNA binding;protein binding,"Pf00102, Pf04560",5782,ENSG00000127947.15,PTPN12,7,,EGF/EGFR Signaling Pathway,Downregulation of ERBB2 signaling; EGFR downregulation; Signaling by PDGF; SHC1 events in ERBB2 signaling,9,High,1
Q9NQP4,Prefoldin subunit 4 OS=Homo sapiens OX=9606 GN=PFDN4 PE=1 SV=1,0,24.044,20,2,19,2,134,15.3,4.53,10902,,2,,metabolic process,cytoplasm;cytosol;mitochondrion;nucleus,protein binding,Pf01920,5203,ENSG00000101132.9,PFDN4,20,,,Prefoldin mediated transfer of substrate  to CCT/TriC,5,High,1
Q96GA7,Serine dehydratase-like OS=Homo sapiens OX=9606 GN=SDSL PE=1 SV=1,0,24.041,16,4,19,4,329,34.7,6.89,7191,,4,,metabolic process,mitochondrion,catalytic activity;protein binding,Pf00291,113675,ENSG00000139410.14,SDSL,12,"Valine, leucine and isoleucine biosynthesis; Carbon metabolism; Cysteine and methionine metabolism; Biosynthesis of amino acids; Metabolic pathways; Glycine, serine and threonine metabolism",,,6,High,1
P21359,Neurofibromin OS=Homo sapiens OX=9606 GN=NF1 PE=1 SV=2,0,24.028,2,6,21,6,2839,319.2,7.39,8089,,6,,cell communication;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus,enzyme regulator activity;protein binding,"Pf00616, Pf13716",4763,ENSG00000196712.17,NF1,17,Ras signaling pathway; MAPK signaling pathway; EGFR tyrosine kinase inhibitor resistance,Signaling Pathways in Glioblastoma; Aryl Hydrocarbon Receptor; Mecp2 and Associated Rett Syndrome; MAPK Signaling Pathway,Regulation of RAS by GAPs; RAS signaling downstream of NF1 loss-of-function variants; Signaling by RAS mutants; Interleukin-20 family signaling,21,High,1
Q9NW68,BSD domain-containing protein 1 OS=Homo sapiens OX=9606 GN=BSDC1 PE=1 SV=1,0,24.011,13,4,24,4,430,47.1,4.49,7357,,4,,,,,Pf03909,55108,ENSG00000160058.18,BSDC1,1,,,,0,High,1
P35542,Serum amyloid A-4 protein OS=Homo sapiens OX=9606 GN=SAA4 PE=1 SV=2,0,24.005,20,2,37,2,130,14.7,9.07,14856,0,2,1,cellular component movement;defense response;response to stimulus,extracellular,,Pf00277,6291,ENSG00000148965.9,SAA4,11,,Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism,,3,High,1
P0CG08,Golgi pH regulator B OS=Homo sapiens OX=9606 GN=GPR89B PE=1 SV=1,0,24.004,14,5,17,5,455,52.9,9.28,6693,,5,,cellular homeostasis;regulation of biological process;response to stimulus;transport,Golgi;membrane,signal transducer activity;transporter activity,"Pf12430, Pf12537",653519; 51463,ENSG00000188092.14; ENSG00000117262.18,GPR89A; GPR89B,1,,,,0,High,1
Q96DD0,Leucine-rich repeat-containing protein 39 OS=Homo sapiens OX=9606 GN=LRRC39 PE=1 SV=1,0,23.977,16,5,22,5,335,38.8,6.34,,39.21,,5,,cytoplasm,protein binding,"Pf12799, Pf13855",127495,ENSG00000122477.12,LRRC39,1,,,,0,High,1
Q8WYP5,Protein ELYS OS=Homo sapiens OX=9606 GN=AHCTF1 PE=1 SV=3,0,23.922,5,8,16,8,2266,252.3,6.6,4441,,8,,cell division;cell organization and biogenesis;regulation of biological process;transport,chromosome;cytoplasm;cytosol;membrane;nucleus,DNA binding;protein binding,Pf13934,25909,,AHCTF1,1,,Gastric cancer network 2,Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins,17,High,1
Q13426,DNA repair protein XRCC4 OS=Homo sapiens OX=9606 GN=XRCC4 PE=1 SV=2,0,23.897,23,6,14,6,336,38.3,4.98,6068,,6,,metabolic process;regulation of biological process;response to stimulus,chromosome;cytosol;nucleus,catalytic activity;DNA binding;motor activity;protein binding,Pf06632,7518,ENSG00000152422.15,XRCC4,5,Non-homologous end-joining,Non-homologous end joining,2-LTR circle formation; Nonhomologous End-Joining (NHEJ); SUMOylation of DNA damage response and repair proteins,17,High,1
Q7L4E1,Mitoguardin 2 OS=Homo sapiens OX=9606 GN=MIGA2 PE=1 SV=1,0,23.893,15,6,16,6,593,65.5,5.83,4303,2.12,4,2,cell organization and biogenesis,membrane;mitochondrion,protein binding,Pf10265,84895,ENSG00000148343.18,FAM73B; MIGA2,9,,,Synthesis of PA,5,High,1
Q00536,Cyclin-dependent kinase 16 OS=Homo sapiens OX=9606 GN=CDK16 PE=1 SV=1,0,23.861,14,6,18,6,496,55.7,7.62,7598,,6,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf07714, Pf14531",5127,ENSG00000102225.15,CDK16,X,,,,0,High,1
Q9Y4P8,WD repeat domain phosphoinositide-interacting protein 2 OS=Homo sapiens OX=9606 GN=WIPI2 PE=1 SV=1,0,23.841,14,5,34,5,454,49.4,6.46,12856,,5,,cell communication;cell organization and biogenesis;metabolic process;response to stimulus,cytosol;membrane;vacuole,protein binding,,26100,ENSG00000157954.14,WIPI2,7,,,Macroautophagy,2,High,1
Q9Y3E0,Vesicle transport protein GOT1B OS=Homo sapiens OX=9606 GN=GOLT1B PE=1 SV=1,0,23.823,17,3,30,3,138,15.4,10.36,12534,,3,,regulation of biological process;response to stimulus;transport,endoplasmic reticulum;Golgi;membrane,signal transducer activity,Pf04178,51026,ENSG00000111711.9,GOLT1B,12,,,,0,High,1
Q9BYT3,Serine/threonine-protein kinase 33 OS=Homo sapiens OX=9606 GN=STK33 PE=1 SV=1,0,23.798,12,4,7,4,514,57.8,7.03,3915,,4,,metabolic process;regulation of biological process;response to stimulus,cytoplasm,catalytic activity;nucleotide binding,"Pf00069, Pf06317, Pf07714",65975,ENSG00000130413.15,STK33,11,,,,0,High,1
O75157,TSC22 domain family protein 2 OS=Homo sapiens OX=9606 GN=TSC22D2 PE=1 SV=3,0,23.783,8,4,22,1,780,79.2,5.02,8535,,4,,cell organization and biogenesis;metabolic process;regulation of biological process;reproduction;response to stimulus,cytoplasm;nucleus,,"Pf01166, Pf04977, Pf06005, Pf06156, Pf15619",9819,ENSG00000196428.12,TSC22D2,3,,,,0,High,1
Q9H1Y0,Autophagy protein 5 OS=Homo sapiens OX=9606 GN=ATG5 PE=1 SV=2,0,23.762,14,3,16,3,275,32.4,5.77,6630,,3,,cell communication;cell death;cell organization and biogenesis;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;vacuole,catalytic activity;protein binding,Pf04106,9474,ENSG00000057663.14,ATG5,6,RIG-I-like receptor signaling pathway; Longevity regulating pathway - multiple species; Longevity regulating pathway; NOD-like receptor signaling pathway; Shigellosis; Autophagy,Nanoparticle triggered autophagic cell death; RIG-I-like Receptor Signaling; Senescence and Autophagy in Cancer,Macroautophagy; Receptor Mediated Mitophagy; Negative regulators of DDX58/IFIH1 signaling; Pink/Parkin Mediated Mitophagy,18,High,1
P08311,Cathepsin G OS=Homo sapiens OX=9606 GN=CTSG PE=1 SV=2,0,23.727,15,4,45,4,255,28.8,11.19,18742,0,4,1,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;extracellular;membrane;nucleus;organelle lumen,catalytic activity;protein binding,Pf00089,1511,ENSG00000100448.3,CTSG,14,Renin-angiotensin system; Amoebiasis; Systemic lupus erythematosus; Neuroactive ligand-receptor interaction; Lysosome,ACE Inhibitor Pathway,Activation of Matrix Metalloproteinases; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Metabolism of Angiotensinogen to Angiotensins; Antimicrobial peptides; Neutrophil degranulation,17,High,1
Q96C36,Pyrroline-5-carboxylate reductase 2 OS=Homo sapiens OX=9606 GN=PYCR2 PE=1 SV=1,0,23.707,19,5,17,5,320,33.6,7.77,6486,,5,,metabolic process;response to stimulus,cytoplasm;mitochondrion;organelle lumen,catalytic activity;nucleotide binding,"Pf01210, Pf03807, Pf14748",29920,ENSG00000143811.18,PYCR2,1,Biosynthesis of amino acids; Arginine and proline metabolism; Metabolic pathways,,Amino acid synthesis and interconversion (transamination),6,High,1
Q9H9H4,Vacuolar protein sorting-associated protein 37B OS=Homo sapiens OX=9606 GN=VPS37B PE=1 SV=1,0,23.686,17,3,13,3,285,31.3,7.34,6549,,3,,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;endosome;membrane,protein binding,Pf07200,79720,ENSG00000139722.6,VPS37B,12,Endocytosis,,Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); Membrane binding and targetting of GAG proteins,13,High,1
Q9Y6M7,Sodium bicarbonate cotransporter 3 OS=Homo sapiens OX=9606 GN=SLC4A7 PE=1 SV=2,0,23.658,6,5,11,5,1214,136,6.71,3741,2.2,4,1,cellular homeostasis;transport,membrane,transporter activity,"Pf00359, Pf00955, Pf07565",9497,ENSG00000033867.16,SLC4A7,3,,,Bicarbonate transporters,4,High,1
Q86VP1,Tax1-binding protein 1 OS=Homo sapiens OX=9606 GN=TAX1BP1 PE=1 SV=2,0,23.652,9,5,8,5,789,90.8,5.43,3890,,5,,cell death;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process,cytosol,catalytic activity;metal ion binding;motor activity;protein binding,"Pf01576, Pf02463, Pf04156, Pf05483, Pf05557, Pf05622, Pf05911, Pf07888, Pf09304, Pf09726, Pf10174, Pf11559, Pf12128, Pf12718, Pf13166, Pf13851",8887,ENSG00000106052.13,TAX1BP1,7,,,Regulation of TNFR1 signaling; Negative regulators of DDX58/IFIH1 signaling,8,High,1
P18077,60S ribosomal protein L35a OS=Homo sapiens OX=9606 GN=RPL35A PE=1 SV=2,0,23.637,27,4,137,4,110,12.5,11.06,63492,,4,,cell organization and biogenesis;metabolic process;transport,cytosol;membrane;ribosome,protein binding;RNA binding;structural molecule activity,Pf01247,6165,ENSG00000182899.14,RPL35A,3,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
Q5NDL2,EGF domain-specific O-linked N-acetylglucosamine transferase OS=Homo sapiens OX=9606 GN=EOGT PE=1 SV=1,0,23.599,10,5,22,5,527,62,7.05,8334,1.91,5,1,metabolic process,endoplasmic reticulum;organelle lumen,catalytic activity,Pf04577,285203,ENSG00000163378.13,EOGT,3,Other types of O-glycan biosynthesis,,,1,High,1
P46952,"3-hydroxyanthranilate 3,4-dioxygenase OS=Homo sapiens OX=9606 GN=HAAO PE=1 SV=2",0,23.555,36,6,18,6,286,32.5,5.88,5301,,6,,cellular homeostasis;metabolic process;response to stimulus,cytoplasm;cytosol,catalytic activity;metal ion binding;protein binding,"Pf06052, Pf07883",23498,ENSG00000162882.14,HAAO,2,Metabolic pathways; Tryptophan metabolism,NAD Biosynthesis II (from tryptophan); Tryptophan metabolism,Tryptophan catabolism,8,High,1
O76062,Delta(14)-sterol reductase TM7SF2 OS=Homo sapiens OX=9606 GN=TM7SF2 PE=1 SV=3,0,23.555,12,3,41,3,418,46.4,8.87,19865,,3,,metabolic process;regulation of biological process,endoplasmic reticulum;membrane,catalytic activity;nucleotide binding,"Pf01222, Pf06966",7108,ENSG00000149809.14,TM7SF2,11,Metabolic pathways; Steroid biosynthesis,,Cholesterol biosynthesis; Activation of gene expression by SREBF (SREBP),8,High,1
Q9UNA1,Rho GTPase-activating protein 26 OS=Homo sapiens OX=9606 GN=ARHGAP26 PE=1 SV=1,0,23.547,7,4,11,3,814,92.2,6.64,4911,,4,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol,enzyme regulator activity;protein binding,"Pf00018, Pf00169, Pf00620, Pf07653, Pf14604",23092,ENSG00000145819.15,ARHGAP26,5,,,Rho GTPase cycle,3,High,1
O00160,Unconventional myosin-If OS=Homo sapiens OX=9606 GN=MYO1F PE=1 SV=3,0,23.526,6,6,21,1,1098,124.8,9.11,7311,,6,,,,catalytic activity;motor activity;nucleotide binding;protein binding,"Pf00018, Pf00063, Pf06017, Pf07653, Pf14604",4542,ENSG00000142347.16,MYO1F,19,,,,0,High,1
O14734,Acyl-coenzyme A thioesterase 8 OS=Homo sapiens OX=9606 GN=ACOT8 PE=1 SV=1,0,23.5,17,4,22,4,319,35.9,7.56,8445,,4,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;mitochondrion;organelle lumen,catalytic activity;protein binding,"Pf02551, Pf13622",10005,ENSG00000101473.16,ACOT8,20,Metabolic pathways; Primary bile acid biosynthesis; Peroxisome,,Beta-oxidation of pristanoyl-CoA; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of very long chain fatty acids,15,High,1
O14933,Ubiquitin/ISG15-conjugating enzyme E2 L6 OS=Homo sapiens OX=9606 GN=UBE2L6 PE=1 SV=4,0,23.475,32,3,19,3,153,17.8,7.88,10011,,3,,metabolic process;regulation of biological process;response to stimulus,cytosol,catalytic activity;protein binding,Pf00179,9246,ENSG00000156587.15,UBE2L6,11,Ubiquitin mediated proteolysis; Parkinson's disease,Parkin-Ubiquitin Proteasomal System pathway; Parkinsons Disease Pathway,Termination of translesion DNA synthesis; ISG15 antiviral mechanism; Amyloid fiber formation; Negative regulators of DDX58/IFIH1 signaling; Antigen processing: Ubiquitination & Proteasome degradation,21,High,1
P19387,DNA-directed RNA polymerase II subunit RPB3 OS=Homo sapiens OX=9606 GN=POLR2C PE=1 SV=2,0,23.466,25,5,24,5,275,31.4,4.92,9074,,5,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;nucleus,catalytic activity;DNA binding;protein binding,"Pf01000, Pf01193",5432,ENSG00000102978.12,POLR2C,16,Pyrimidine metabolism; Purine metabolism; RNA polymerase; Epstein-Barr virus infection; Metabolic pathways; Huntington's disease,Eukaryotic Transcription Initiation,Signaling by FGFR2 IIIa TM; RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Formation of HIV-1 elongation complex containing HIV-1 Tat; MicroRNA (miRNA) biogenesis; Formation of the HIV-1 Early Elongation Complex; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; TP53 Regulates Transcription of DNA Repair Genes; Transcriptional regulation by small RNAs; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; RNA Polymerase II HIV Promoter Escape; Formation of HIV elongation complex in the absence of HIV Tat; Transcriptional regulation of pluripotent stem cells; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; Formation of TC-NER Pre-Incision Complex; Pausing and recovery of HIV elongation; RNA Polymerase II Promoter Escape; HIV elongation arrest and recovery; RNA Pol II CTD phosphorylation and interaction with CE; Viral Messenger RNA Synthesis; RNA Polymerase II Transcription Initiation; mRNA Capping; Dual incision in TC-NER; PIWI-interacting RNA (piRNA) biogenesis; Pausing and recovery of Tat-mediated HIV elongation; Formation of the Early Elongation Complex,75,High,1
Q15274,Nicotinate-nucleotide pyrophosphorylase [carboxylating] OS=Homo sapiens OX=9606 GN=QPRT PE=1 SV=3,0,23.458,14,4,41,4,297,30.8,6.21,13849,,4,,cell organization and biogenesis;metabolic process,cytoplasm;cytosol,catalytic activity;protein binding,"Pf01729, Pf02581, Pf02749",23475,ENSG00000103485.17,QPRT,16,Metabolic pathways; Nicotinate and nicotinamide metabolism,NAD Biosynthesis II (from tryptophan); NAD+ biosynthetic pathways,Nicotinate metabolism,8,High,1
Q96G23,Ceramide synthase 2 OS=Homo sapiens OX=9606 GN=CERS2 PE=1 SV=1,0,23.443,17,5,14,5,380,44.8,8.98,3584,0,5,1,metabolic process;regulation of biological process,endoplasmic reticulum;membrane;nucleus,catalytic activity;DNA binding;protein binding,Pf03798,29956,ENSG00000143418.19,CERS2,1,Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway,Sphingolipid Metabolism,Sphingolipid de novo biosynthesis,8,High,1
Q9UEU0,Vesicle transport through interaction with t-SNAREs homolog 1B OS=Homo sapiens OX=9606 GN=VTI1B PE=1 SV=3,0,23.431,28,5,13,5,232,26.7,9.04,5473,0,5,1,cell organization and biogenesis;cell proliferation;regulation of biological process;transport,cytosol;endosome;extracellular;Golgi;membrane;organelle lumen;vacuole,protein binding,"Pf03908, Pf05008, Pf12352",10490,ENSG00000100568.10,VTI1B,14,SNARE interactions in vesicular transport,,Platelet degranulation,5,High,1
Q9NWB1,RNA binding protein fox-1 homolog 1 OS=Homo sapiens OX=9606 GN=RBFOX1 PE=1 SV=2,0,23.395,14,4,22,1,397,42.8,6.86,8140,9.8,3,1,metabolic process;regulation of biological process;transport,cytoplasm;nucleus,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",54715,ENSG00000078328.19,RBFOX1,16,,Mecp2 and Associated Rett Syndrome,,1,High,1
Q96A32,"Myosin regulatory light chain 2, skeletal muscle isoform OS=Homo sapiens OX=9606 GN=MYLPF PE=2 SV=1",0,23.299,13,3,438,1,169,19,5.01,203138,,3,,response to stimulus,cytosol;membrane,metal ion binding;structural molecule activity,"Pf00036, Pf13405, Pf13833",29895,ENSG00000180209.11,MYLPF,16,Focal adhesion; Leukocyte transendothelial migration; Tight junction; Regulation of actin cytoskeleton,,Smooth Muscle Contraction,6,High,1
P04233,HLA class II histocompatibility antigen gamma chain OS=Homo sapiens OX=9606 GN=CD74 PE=1 SV=3,0,23.262,19,4,16,4,296,33.5,8.44,7208,,4,,cell organization and biogenesis;cell proliferation;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;endoplasmic reticulum;endosome;Golgi;membrane;organelle lumen;vacuole,protein binding;receptor activity;signal transducer activity,"Pf00086, Pf08831, Pf09307",972,ENSG00000019582.14,CD74,5,Herpes simplex infection; Antigen processing and presentation; Tuberculosis,,MHC class II antigen presentation; Cell surface interactions at the vascular wall,8,High,1
Q96QZ7,"Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 OS=Homo sapiens OX=9606 GN=MAGI1 PE=1 SV=3",0,23.244,5,6,14,5,1491,164.5,7.58,4908,,6,,cell death;cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;membrane;nucleus,nucleotide binding;protein binding;structural molecule activity,"Pf00397, Pf00595, Pf00625, Pf13180",9223,,MAGI1,3,Rap1 signaling pathway; Tight junction,Pathways Affected in Adenoid Cystic Carcinoma,,3,High,1
P49908,Selenoprotein P OS=Homo sapiens OX=9606 GN=SELENOP PE=1 SV=3,0,23.23,12,5,30,5,381,43.2,7.87,14148,,5,,metabolic process;reproduction;response to stimulus;transport,extracellular;organelle lumen,,"Pf04592, Pf04593",6414,ENSG00000250722.5,SEPP1; SELENOP,5,,Selenium Micronutrient Network; Integrin-mediated Cell Adhesion; Selenium Metabolism and Selenoproteins; Focal Adhesion; ESC Pluripotency Pathways,Platelet degranulation,9,High,1
Q969E4,Transcription elongation factor A protein-like 3 OS=Homo sapiens OX=9606 GN=TCEAL3 PE=1 SV=1,0,23.214,31,4,31,4,200,22.5,4.92,12869,0,4,1,metabolic process;regulation of biological process,nucleus,protein binding,Pf04538,85012,ENSG00000196507.10,TCEAL3,X,,,,0,High,1
Q96HD1,Protein disulfide isomerase CRELD1 OS=Homo sapiens OX=9606 GN=CRELD1 PE=1 SV=3,0,23.204,11,4,34,4,420,45.4,4.87,13895,,4,,,membrane,metal ion binding,"Pf07645, Pf11938",78987,ENSG00000163703.17,CRELD1,3,,,,0,High,1
Q96I51,RCC1-like G exchanging factor-like protein OS=Homo sapiens OX=9606 GN=RCC1L PE=1 SV=2,0,23.191,15,5,13,5,464,50,8.4,5667,,5,,,mitochondrion,RNA binding,"Pf00415, Pf13540",81554,,WBSCR16; RCC1L,7,,,,0,High,1
Q14449,Growth factor receptor-bound protein 14 OS=Homo sapiens OX=9606 GN=GRB14 PE=1 SV=2,0,23.168,13,4,14,4,540,61,8.29,5216,0,4,1,cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytosol;endosome;membrane,protein binding,"Pf00017, Pf00169, Pf00788, Pf08947",2888,ENSG00000115290.9,GRB14,2,,Rac1/Pak1/p38/MMP-2 pathway; Insulin Signaling,Tie2 Signaling,5,High,1
Q9HC36,"rRNA methyltransferase 3, mitochondrial OS=Homo sapiens OX=9606 GN=MRM3 PE=1 SV=2",0,23.162,14,5,26,5,420,47,8.73,11066,0,5,1,metabolic process,mitochondrion;organelle lumen,catalytic activity;protein binding;RNA binding,"Pf00588, Pf08032",55178,ENSG00000171861.10,RNMTL1; MRM3,17,,,rRNA modification in the mitochondrion,4,High,1
Q86TB9,Protein PAT1 homolog 1 OS=Homo sapiens OX=9606 GN=PATL1 PE=1 SV=2,0,23.152,8,5,18,5,770,86.8,6.67,8897,,5,,cell organization and biogenesis;metabolic process,cytoplasm;cytosol;nucleus,protein binding;RNA binding,Pf09770,219988,ENSG00000166889.13,PATL1,11,RNA degradation,,mRNA decay by 5' to 3' exoribonuclease,4,High,1
Q8WVJ2,NudC domain-containing protein 2 OS=Homo sapiens OX=9606 GN=NUDCD2 PE=1 SV=1,0,23.15,32,4,17,4,157,17.7,5.07,10073,,4,,metabolic process,chromosome;cytoplasm;cytoskeleton;cytosol,protein binding,Pf04969,134492,ENSG00000170584.10,NUDCD2,5,,,,0,High,1
O95445,Apolipoprotein M OS=Homo sapiens OX=9606 GN=APOM PE=1 SV=2,0,23.131,21,3,36,3,188,21.2,6.01,14894,,3,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,extracellular,antioxidant activity;catalytic activity;transporter activity,Pf11032,55937,ENSG00000227567.7; ENSG00000235754.7; ENSG00000231974.6; ENSG00000206409.8; ENSG00000204444.10; ENSG00000224290.7; ENSG00000226215.6,APOM,6; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_MCF_CTG1,,,Signaling by GPCR; Retinoid metabolism and transport,7,High,1
P26022,Pentraxin-related protein PTX3 OS=Homo sapiens OX=9606 GN=PTX3 PE=1 SV=3,0,23.13,20,6,22,6,381,41.9,5.01,8139,,6,,defense response;regulation of biological process;response to stimulus;transport,extracellular;organelle lumen,protein binding,"Pf00354, Pf02210, Pf13385",5806,ENSG00000163661.3,PTX3,3,,Lung fibrosis,Neutrophil degranulation,4,High,1
Q8N4L2,"Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase OS=Homo sapiens OX=9606 GN=PIP4P2 PE=1 SV=1",0,23.125,25,3,14,3,257,28.1,8.68,6754,,3,,metabolic process,endosome;membrane;vacuole,catalytic activity,Pf09788,55529,ENSG00000155099.7,TMEM55A; PIP4P2,8,Phosphatidylinositol signaling system,,,1,High,1
P24666-2,Isoform 2 of Low molecular weight phosphotyrosine protein phosphatase OS=Homo sapiens OX=9606 GN=ACP1,0,23.107,28,3,81,1,158,18,6.87,34107,14.92,2,1,metabolic process,cytoplasm;cytosol;membrane,catalytic activity;protein binding,Pf01451,52,ENSG00000143727.15,ACP1,2,,VEGFA-VEGFR2 Signaling Pathway,,1,High,1
Q9NS18,"Glutaredoxin-2, mitochondrial OS=Homo sapiens OX=9606 GN=GLRX2 PE=1 SV=1",0,23.1,27,3,13,3,164,18,9.11,4657,,3,,cell communication;cell death;cell differentiation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,mitochondrion;nucleus;organelle lumen,catalytic activity;metal ion binding,"Pf00462, Pf13098",51022,ENSG00000023572.8,GLRX2,1,,,,0,High,1
Q6ZT62,Bargin OS=Homo sapiens OX=9606 GN=BARGIN PE=1 SV=2,0,23.086,4,3,13,1,677,73.6,5.24,6806,,3,,regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,enzyme regulator activity;protein binding,"Pf00620, Pf00702, Pf03114, Pf13242, Pf13419",23616; 57026,,SH3BP1; PDXP,22,,,,0,High,1
Q8NFD5,AT-rich interactive domain-containing protein 1B OS=Homo sapiens OX=9606 GN=ARID1B PE=1 SV=2,0,23.08,3,5,16,5,2236,236,6.73,6375,,5,,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,DNA binding;protein binding,"Pf01388, Pf03153, Pf09770, Pf12031",57492,ENSG00000049618.22,ARID1B,6,,,RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines,8,High,1
Q12972,Nuclear inhibitor of protein phosphatase 1 OS=Homo sapiens OX=9606 GN=PPP1R8 PE=1 SV=2,0,23.067,19,5,16,5,351,38.5,7.37,7473,,5,,cell proliferation;metabolic process;regulation of biological process,cytoplasm;nucleus;spliceosomal complex,catalytic activity;DNA binding;enzyme regulator activity;protein binding;RNA binding,Pf00498,5511,ENSG00000117751.17,PPP1R8,1,,,,0,High,1
Q9H201,Epsin-3 OS=Homo sapiens OX=9606 GN=EPN3 PE=2 SV=1,0,23.06,5,3,36,1,632,68.2,5.91,15936,,3,,,cytoplasm;nucleus,protein binding,"Pf01417, Pf07651",55040,ENSG00000049283.17,EPN3,17,Endocytosis,,,1,High,1
Q92572,AP-3 complex subunit sigma-1 OS=Homo sapiens OX=9606 GN=AP3S1 PE=1 SV=1,0,23.034,23,4,37,4,193,21.7,5.39,17088,,4,,cellular component movement;regulation of biological process;response to stimulus;transport,Golgi;membrane,protein binding;transporter activity,Pf01217,1176,ENSG00000177879.15,AP3S1,5,Lysosome,,Golgi Associated Vesicle Biogenesis,6,High,1
Q9BUK0,Coiled-coil-helix-coiled-coil-helix domain-containing protein 7 OS=Homo sapiens OX=9606 GN=CHCHD7 PE=1 SV=1,0,22.98,32,3,53,3,85,10.1,8.82,21253,2.03,3,1,,mitochondrion,catalytic activity;transporter activity,"Pf02297, Pf06747",79145,ENSG00000170791.17,CHCHD7,8,,,Mitochondrial protein import; Metabolism of proteins,2,High,1
Q53GT1,Kelch-like protein 22 OS=Homo sapiens OX=9606 GN=KLHL22 PE=1 SV=2,0,22.971,10,6,18,6,634,71.6,5.49,6955,,6,,cell division;cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytoskeleton;cytosol,catalytic activity;protein binding,"Pf00651, Pf01344, Pf07646, Pf07707, Pf13415, Pf13418, Pf13964",84861,ENSG00000099910.16,KLHL22,22,,,Antigen processing: Ubiquitination & Proteasome degradation; Neddylation,7,High,1
Q96Q05,Trafficking protein particle complex subunit 9 OS=Homo sapiens OX=9606 GN=TRAPPC9 PE=1 SV=2,0,22.961,7,8,21,8,1148,128.4,6.62,8135,,8,,cell differentiation;cell organization and biogenesis;regulation of biological process,cytoplasm;cytosol;endoplasmic reticulum;Golgi;membrane,protein binding,Pf08626,83696,ENSG00000167632.14,TRAPPC9,8,,,RAB GEFs exchange GTP for GDP on RABs; COPII (Coat Protein 2) Mediated Vesicle Transport,10,High,1
Q86VP3,Phosphofurin acidic cluster sorting protein 2 OS=Homo sapiens OX=9606 GN=PACS2 PE=1 SV=3,0,22.925,6,5,30,4,889,97.6,6.6,14614,,5,,cell death;cell organization and biogenesis,endoplasmic reticulum;mitochondrion,protein binding,Pf10254,23241,ENSG00000179364.13,PACS2,14,,,,0,High,1
Q9Y4Y9,U6 snRNA-associated Sm-like protein LSm5 OS=Homo sapiens OX=9606 GN=LSM5 PE=1 SV=3,0,22.914,22,2,20,2,91,9.9,4.54,7917,2.35,1,1,metabolic process,cytosol;nucleus;spliceosomal complex,protein binding;RNA binding,Pf01423,23658,ENSG00000106355.9,LSM5,7,RNA degradation; Spliceosome,,mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease,8,High,1
P07311,Acylphosphatase-1 OS=Homo sapiens OX=9606 GN=ACYP1 PE=1 SV=2,0,22.912,52,5,37,5,99,11.3,9.31,16430,,5,,metabolic process,,catalytic activity,Pf00708,97,ENSG00000119640.8,ACYP1,14,Pyruvate metabolism,,,1,High,1
Q96BQ5,Coiled-coil domain-containing protein 127 OS=Homo sapiens OX=9606 GN=CCDC127 PE=1 SV=1,0,22.888,19,5,28,5,260,30.8,9.2,13179,,5,,,,,,133957,ENSG00000164366.3,CCDC127,5,,,,0,High,1
Q14574,Desmocollin-3 OS=Homo sapiens OX=9606 GN=DSC3 PE=1 SV=3,0,22.882,4,2,21,1,896,99.9,6.1,11310,,2,,cell death;regulation of biological process,cytoskeleton;membrane,metal ion binding;protein binding,"Pf00028, Pf01049, Pf08758",1825,ENSG00000134762.16,DSC3,18,,,Formation of the cornified envelope,3,High,1
Q92805,Golgin subfamily A member 1 OS=Homo sapiens OX=9606 GN=GOLGA1 PE=1 SV=3,0,22.878,10,6,13,6,767,88.1,5.27,3748,,6,,metabolic process;transport,cytosol;Golgi;membrane,catalytic activity;motor activity;protein binding;transporter activity,"Pf01465, Pf01496, Pf01576, Pf04111, Pf04156, Pf04849, Pf07888, Pf08317, Pf10212, Pf12128, Pf13166",2800,ENSG00000136935.13,GOLGA1,9,,,Retrograde transport at the Trans-Golgi-Network,4,High,1
O14896,Interferon regulatory factor 6 OS=Homo sapiens OX=9606 GN=IRF6 PE=1 SV=1,0,22.874,16,5,18,5,467,53.1,5.33,7723,,5,,cell differentiation;cell proliferation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,DNA binding;protein binding,"Pf00605, Pf10401",3664,ENSG00000117595.10,IRF6,1,,Apoptosis; Primary Focal Segmental Glomerulosclerosis FSGS; Hypothetical Craniofacial Development Pathway,Interferon alpha/beta signaling; Interferon gamma signaling,8,High,1
Q96N66,Lysophospholipid acyltransferase 7 OS=Homo sapiens OX=9606 GN=MBOAT7 PE=1 SV=2,0,22.861,13,4,13,4,472,52.7,8.97,6512,,4,,metabolic process,membrane,catalytic activity;protein binding,Pf03062,79143,ENSG00000278519.4; ENSG00000277025.4; ENSG00000277923.4; ENSG00000277733.4; ENSG00000274194.4; ENSG00000273592.4; ENSG00000276935.4; ENSG00000278322.4; ENSG00000125505.16; ENSG00000275118.4,MBOAT7,19; CHR_HSCHR19LRC_LRC_I_CTG3_1; CHR_HSCHR19LRC_LRC_J_CTG3_1; CHR_HSCHR19LRC_LRC_T_CTG3_1; CHR_HSCHR19LRC_LRC_S_CTG3_1; CHR_HSCHR19LRC_PGF2_CTG3_1; CHR_HSCHR19LRC_PGF1_CTG3_1; CHR_HSCHR19LRC_COX1_CTG3_1; CHR_HSCHR19LRC_COX2_CTG3_1; CHR_HSCHR19_4_CTG3_1,Glycerophospholipid metabolism,,Acyl chain remodelling of PI,6,High,1
Q8NB90,ATPase family protein 2 homolog OS=Homo sapiens OX=9606 GN=SPATA5 PE=1 SV=3,0,22.859,10,6,61,5,893,97.8,5.66,22939,0,6,1,cell differentiation;development;metabolic process;response to stimulus,cytoplasm;mitochondrion,catalytic activity;nucleotide binding;RNA binding,"Pf00004, Pf00910, Pf01057, Pf01078, Pf05496, Pf06068, Pf06414, Pf07724, Pf07726, Pf07728, Pf13173, Pf13191, Pf13401",166378,ENSG00000145375.7,SPATA5,4,Ribosome biogenesis in eukaryotes,,,1,High,1
Q86VB7,Scavenger receptor cysteine-rich type 1 protein M130 OS=Homo sapiens OX=9606 GN=CD163 PE=1 SV=2,0,22.856,4,4,29,4,1156,125.4,5.95,10251,,4,,defense response;response to stimulus;transport,extracellular;membrane,protein binding;receptor activity,Pf00530,9332,ENSG00000177575.12,CD163,12,,,Scavenging of heme from plasma,3,High,1
A0A075B6K4,Immunoglobulin lambda variable 3-10 OS=Homo sapiens OX=9606 GN=IGLV3-10 PE=3 SV=2,0,22.854,36,3,22,1,115,12.4,4.83,10634,,3,,response to stimulus,extracellular;membrane,,"Pf00047, Pf07679, Pf07686",28803,,IGLV3-10,22,,,,0,High,1
P35244,Replication protein A 14 kDa subunit OS=Homo sapiens OX=9606 GN=RPA3 PE=1 SV=1,0,22.852,28,4,28,4,121,13.6,5.08,13436,,4,,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,nucleus,DNA binding;protein binding,Pf08661,6119,ENSG00000106399.11,RPA3,7,Homologous recombination; Nucleotide excision repair; DNA replication; Mismatch repair; Fanconi anemia pathway,Retinoblastoma (RB) in Cancer; G1 to S cell cycle control; DNA Replication,Translesion Synthesis by POLH; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Activation of the pre-replicative complex; Termination of translesion DNA synthesis; Translesion synthesis by POLI; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Meiotic recombination; Removal of the Flap Intermediate; Regulation of TP53 Activity through Phosphorylation; PCNA-Dependent Long Patch Base Excision Repair; G2/M DNA damage checkpoint; Translesion synthesis by POLK; Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Gap-filling DNA repair synthesis and ligation in TC-NER; Regulation of HSF1-mediated heat shock response; Presynaptic phase of homologous DNA pairing and strand exchange; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Fanconi Anemia Pathway; HSF1 activation; M/G1 Transition; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA); Removal of the Flap Intermediate from the C-strand,79,High,1
P05386,60S acidic ribosomal protein P1 OS=Homo sapiens OX=9606 GN=RPLP1 PE=1 SV=1,0,22.845,43,3,72,2,114,11.5,4.32,37478,,3,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytosol;ribosome,enzyme regulator activity;protein binding;structural molecule activity,Pf00428,6176,ENSG00000137818.11,RPLP1,15,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
Q9UI08,Ena/VASP-like protein OS=Homo sapiens OX=9606 GN=EVL PE=1 SV=2,0,22.816,10,4,29,4,416,44.6,8.84,15130,,4,,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane,protein binding,"Pf00568, Pf08776",51466,ENSG00000196405.12,EVL,14,,,RHO GTPases Activate Formins; Generation of second messenger molecules; Signaling by ROBO receptors,11,High,1
Q9Y3I1,F-box only protein 7 OS=Homo sapiens OX=9606 GN=FBXO7 PE=1 SV=1,0,22.811,14,5,23,5,522,58.5,6.55,10419,,5,,metabolic process;regulation of biological process;transport,cytoplasm;cytosol;mitochondrion;nucleus,catalytic activity;protein binding,"Pf11566, Pf12937",25793,ENSG00000100225.17,FBXO7,22,,,Antigen processing: Ubiquitination & Proteasome degradation; Neddylation,7,High,1
O15075,Serine/threonine-protein kinase DCLK1 OS=Homo sapiens OX=9606 GN=DCLK1 PE=1 SV=2,0,22.811,7,4,11,4,740,82.2,8.66,5984,,4,,cell differentiation;cell growth;cell organization and biogenesis;cellular component movement;development;metabolic process;regulation of biological process;response to stimulus;transport,,catalytic activity;nucleotide binding;signal transducer activity,"Pf00069, Pf03607, Pf07714, Pf14531",9201,ENSG00000133083.14,DCLK1,13,,,,0,High,1
O60306,RNA helicase aquarius OS=Homo sapiens OX=9606 GN=AQR PE=1 SV=4,0,22.809,5,5,8,5,1485,171.2,6.37,3889,,5,,metabolic process;response to stimulus,membrane;nucleus;spliceosomal complex,catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding,"Pf04851, Pf13086, Pf13087, Pf13245, Pf13538",9716,ENSG00000021776.10,AQR,15,Spliceosome,,Dual incision in TC-NER; Formation of TC-NER Pre-Incision Complex; mRNA Splicing - Major Pathway; Gap-filling DNA repair synthesis and ligation in TC-NER,11,High,1
P13984,General transcription factor IIF subunit 2 OS=Homo sapiens OX=9606 GN=GTF2F2 PE=1 SV=2,0,22.79,22,5,16,5,249,28.4,9.23,7306,,5,,metabolic process;regulation of biological process;response to stimulus,cytoskeleton;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding,Pf02270,2963,ENSG00000188342.11,GTF2F2,13,Basal transcription factors,Eukaryotic Transcription Initiation,Signaling by FGFR2 IIIa TM; RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; Formation of HIV-1 elongation complex containing HIV-1 Tat; Formation of the HIV-1 Early Elongation Complex; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; TP53 Regulates Transcription of DNA Repair Genes; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; RNA Polymerase II HIV Promoter Escape; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; Pausing and recovery of HIV elongation; RNA Polymerase II Promoter Escape; HIV elongation arrest and recovery; RNA Pol II CTD phosphorylation and interaction with CE; Viral Messenger RNA Synthesis; RNA Polymerase II Transcription Initiation; mRNA Capping; Pausing and recovery of Tat-mediated HIV elongation; Formation of the Early Elongation Complex,56,High,1
Q8NFH5,Nucleoporin NUP35 OS=Homo sapiens OX=9606 GN=NUP35 PE=1 SV=1,0,22.781,23,4,14,4,326,34.8,9.09,4428,,4,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,membrane;nucleus,DNA binding;protein binding;transporter activity,"Pf05172, Pf13893, Pf14605",129401,ENSG00000163002.12,NUP35,2,RNA transport,,Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins,64,High,1
P17900,Ganglioside GM2 activator OS=Homo sapiens OX=9606 GN=GM2A PE=1 SV=4,0,22.78,17,4,71,4,193,20.8,5.31,35497,1.67,4,1,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;extracellular;mitochondrion;organelle lumen;vacuole,catalytic activity;enzyme regulator activity;transporter activity,"Pf02221, Pf06477",2760,ENSG00000196743.8,GM2A,5,Lysosome,,Glycosphingolipid metabolism; Neutrophil degranulation,8,High,1
P33908,"Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA OS=Homo sapiens OX=9606 GN=MAN1A1 PE=1 SV=3",0,22.751,14,6,25,6,653,72.9,6.47,9152,,6,,metabolic process,cytosol;endoplasmic reticulum;Golgi;membrane,catalytic activity;metal ion binding,Pf01532,4121,ENSG00000111885.6,MAN1A1,6,Protein processing in endoplasmic reticulum; Metabolic pathways; N-Glycan biosynthesis,,"Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2; Intra-Golgi traffic",13,High,1
P62877,E3 ubiquitin-protein ligase RBX1 OS=Homo sapiens OX=9606 GN=RBX1 PE=1 SV=1,0,22.746,22,2,24,2,108,12.3,6.96,12556,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;protein binding,"Pf00097, Pf12678, Pf12861, Pf13639",9978,ENSG00000100387.8,RBX1,22,Pathways in cancer; Cell cycle; Renal cell carcinoma; HIF-1 signaling pathway; Oocyte meiosis; Nucleotide excision repair; Protein processing in endoplasmic reticulum; Ubiquitin mediated proteolysis; Circadian rhythm; TGF-beta signaling pathway; Wnt signaling pathway,Dual hijack model of Vif in HIV infection; TGF-beta Signaling Pathway,FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; NOTCH1 Intracellular Domain Regulates Transcription; Regulation of RAS by GAPs; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Antigen processing: Ubiquitination & Proteasome degradation; GLI3 is processed to GLI3R by the proteasome; Interleukin-1 family signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; Interleukin-20 family signaling; Regulation of RUNX2 expression and activity; Hedgehog 'on' state; Gap-filling DNA repair synthesis and ligation in TC-NER; Degradation of DVL; Formation of TC-NER Pre-Incision Complex; Dual Incision in GG-NER; Prolactin receptor signaling; Neddylation; Degradation of beta-catenin by the destruction complex; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling; Dual incision in TC-NER; Regulation of expression of SLITs and ROBOs,87,High,1
Q96BJ3,"Axin interactor, dorsalization-associated protein OS=Homo sapiens OX=9606 GN=AIDA PE=1 SV=1",0,22.746,22,5,19,5,306,35,6.55,9296,,5,,development;regulation of biological process,cytoplasm;membrane,protein binding,"Pf08910, Pf14186",64853,ENSG00000186063.12,AIDA,1,,,,0,High,1
Q562E7,WD repeat-containing protein 81 OS=Homo sapiens OX=9606 GN=WDR81 PE=1 SV=2,0,22.732,6,6,8,6,1941,211.6,5.58,2997,,6,,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;Golgi;membrane;mitochondrion;vacuole,enzyme regulator activity;protein binding,"Pf00400, Pf02138",124997,ENSG00000167716.18,WDR81,17,,,,0,High,1
Q08499,"cAMP-specific 3',5'-cyclic phosphodiesterase 4D OS=Homo sapiens OX=9606 GN=PDE4D PE=1 SV=2",0,22.711,9,6,14,6,809,91.1,5.54,5067,,6,,cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding,Pf00233,5144,ENSG00000113448.18,PDE4D,5,cAMP signaling pathway; Purine metabolism; Morphine addiction,Human Thyroid Stimulating Hormone (TSH) signaling pathway; Myometrial Relaxation and Contraction Pathways; G Protein Signaling Pathways,G alpha (s) signalling events; DARPP-32 events,12,High,1
Q9NWM8,Peptidyl-prolyl cis-trans isomerase FKBP14 OS=Homo sapiens OX=9606 GN=FKBP14 PE=1 SV=1,0,22.705,32,5,32,5,211,24.2,6.07,10617,0,5,1,metabolic process,cytoplasm;endoplasmic reticulum;organelle lumen,catalytic activity;metal ion binding,Pf00254,55033,ENSG00000106080.10,FKBP14,7,,,XBP1(S) activates chaperone genes,4,High,1
Q6GYQ0,Ral GTPase-activating protein subunit alpha-1 OS=Homo sapiens OX=9606 GN=RALGAPA1 PE=1 SV=1,0,22.704,2,5,48,5,2036,229.7,6.19,24010,,5,,regulation of biological process,cytoplasm;nucleus,enzyme regulator activity;protein binding,Pf02145,253959,ENSG00000174373.16,RALGAPA1,14,,Integrated Breast Cancer Pathway,,1,High,1
Q16619,Cardiotrophin-1 OS=Homo sapiens OX=9606 GN=CTF1 PE=1 SV=1,0,22.701,16,2,9,2,201,21.2,9.01,3861,3.44,1,1,cell communication;cell proliferation;regulation of biological process;response to stimulus,extracellular,protein binding,,1489,ENSG00000150281.6,CTF1,16,Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction,Physiological and Pathological Hypertrophy  of the Heart; MicroRNAs in cardiomyocyte hypertrophy,IL-6-type cytokine receptor ligand interactions,9,High,1
Q8IVP5,FUN14 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FUNDC1 PE=1 SV=1,0,22.695,19,2,65,2,155,17.2,8.62,27031,,2,,cell communication;metabolic process;response to stimulus,membrane;mitochondrion,protein binding,Pf04930,139341,ENSG00000069509.5,FUNDC1,X,,,Receptor Mediated Mitophagy,2,High,1
O75934,Pre-mRNA-splicing factor SPF27 OS=Homo sapiens OX=9606 GN=BCAS2 PE=1 SV=1,0,22.689,35,6,16,6,225,26.1,5.66,4867,,6,,cell organization and biogenesis;metabolic process,nucleus;spliceosomal complex,protein binding,Pf05700,10286,ENSG00000116752.5,BCAS2,1,Spliceosome,,mRNA Splicing - Major Pathway,5,High,1
Q9UPN6,SR-related and CTD-associated factor 8 OS=Homo sapiens OX=9606 GN=SCAF8 PE=1 SV=1,0,22.663,5,6,33,6,1271,140.4,8.29,12442,0,6,1,metabolic process,nucleus;spliceosomal complex,protein binding;RNA binding,"Pf00076, Pf04818, Pf13893, Pf14259",22828,ENSG00000213079.9,SCAF8,6,,,,0,High,1
Q5HYI8,Rab-like protein 3 OS=Homo sapiens OX=9606 GN=RABL3 PE=1 SV=1,0,22.644,21,4,43,4,236,26.4,7.11,18378,,4,,regulation of biological process;response to stimulus,,nucleotide binding,"Pf00071, Pf08477",285282,ENSG00000144840.8,RABL3,3,,,,0,High,1
Q9Y4G8,Rap guanine nucleotide exchange factor 2 OS=Homo sapiens OX=9606 GN=RAPGEF2 PE=1 SV=1,0,22.636,5,6,73,6,1499,167.3,6.67,28273,,6,,cell differentiation;cell organization and biogenesis;cellular component movement;development;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endosome;membrane,enzyme regulator activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,"Pf00027, Pf00595, Pf00617, Pf00618, Pf00788, Pf13180",9693,ENSG00000109756.8,RAPGEF2,4,Rap1 signaling pathway; MAPK signaling pathway,,RAF/MAP kinase cascade; Interleukin-20 family signaling,10,High,1
Q9UI26,Importin-11 OS=Homo sapiens OX=9606 GN=IPO11 PE=1 SV=1,0,22.635,8,5,16,5,975,112.5,5.25,4927,0,5,1,transport,cytoplasm;cytosol;nucleus,protein binding;transporter activity,Pf03810,51194,ENSG00000086200.16,IPO11,5,,,,0,High,1
Q9H910,Jupiter microtubule associated homolog 2 OS=Homo sapiens OX=9606 GN=JPT2 PE=1 SV=1,0,22.625,28,4,19,4,190,20.1,9.26,8703,,4,,,cytoplasm;cytosol;membrane;nucleus,,,90861,ENSG00000206053.12,HN1L; JPT2,16,,,,0,High,1
P54802,Alpha-N-acetylglucosaminidase OS=Homo sapiens OX=9606 GN=NAGLU PE=1 SV=2,0,22.616,9,4,17,4,743,82.2,6.65,6618,,4,,cell organization and biogenesis;metabolic process;response to stimulus,organelle lumen;vacuole,catalytic activity,"Pf05089, Pf12971, Pf12972",4669,ENSG00000108784.9,NAGLU,17,Glycosaminoglycan degradation; Lysosome; Metabolic pathways,,MPS IIIB - Sanfilippo syndrome B; HS-GAG degradation,13,High,1
O43252,Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 OS=Homo sapiens OX=9606 GN=PAPSS1 PE=1 SV=2,0,22.597,9,4,24,4,624,70.8,6.86,7761,,4,,metabolic process,cytosol,catalytic activity;nucleotide binding;protein binding,"Pf01583, Pf01747, Pf02223, Pf08433, Pf13207, Pf13238, Pf13671, Pf14306",9061,ENSG00000138801.8,PAPSS1,4,Selenocompound metabolism; Metabolic pathways; Sulfur metabolism; Purine metabolism,Sulfation Biotransformation Reaction,Transport and synthesis of PAPS; Signaling by BRAF and RAF fusions; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se,19,High,1
Q9NUY8,TBC1 domain family member 23 OS=Homo sapiens OX=9606 GN=TBC1D23 PE=1 SV=3,0,22.581,10,4,13,4,699,78.3,5.41,5879,,4,,regulation of biological process,Golgi,protein binding,"Pf00566, Pf00581",55773,ENSG00000036054.12,TBC1D23,3,,,,0,High,1
Q9Y4C2,TRPM8 channel-associated factor 1 OS=Homo sapiens OX=9606 GN=TCAF1 PE=1 SV=3,0,22.577,8,6,31,6,921,102.1,6.54,10752,,6,,regulation of biological process;transport,membrane,protein binding,Pf13402,9747,ENSG00000198420.9,FAM115A; TCAF1,7,,,,0,High,1
P84022,Mothers against decapentaplegic homolog 3 OS=Homo sapiens OX=9606 GN=SMAD3 PE=1 SV=1,0,22.521,8,3,36,2,425,48.1,7.15,16475,,3,,cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus,DNA binding;metal ion binding;protein binding;RNA binding;signal transducer activity,"Pf03165, Pf03166",4088,ENSG00000166949.15,SMAD3,15,Pancreatic cancer; Signaling pathways regulating pluripotency of stem cells; TGF-beta signaling pathway; Wnt signaling pathway; Pathways in cancer; Chronic myeloid leukemia; Hepatitis B; Adherens junction; Endocytosis; AGE-RAGE signaling pathway in diabetic complications; Hippo signaling pathway; Cell cycle; HTLV-I infection; Colorectal cancer; FoxO signaling pathway; Inflammatory bowel disease (IBD); Chagas disease (American trypanosomiasis),Androgen receptor signaling pathway; Cell Cycle; AGE/RAGE pathway; Adipogenesis; Endoderm Differentiation; Mesodermal Commitment Pathway; Extracellular vesicle-mediated signaling in recipient cells; Ovarian Infertility Genes; Hepatitis C and Hepatocellular Carcinoma; TGF-beta Signaling Pathway; Hypothesized Pathways in Pathogenesis of Cardiovascular Disease; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition; Canonical and Non-Canonical TGF-B signaling; TGF-beta Receptor Signaling; Senescence and Autophagy in Cancer; DNA Damage Response (only ATM dependent),Signaling by NODAL; SMAD2/3 Phosphorylation Motif Mutants in Cancer; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Downregulation of TGF-beta receptor signaling; SMAD4 MH2 Domain Mutants in Cancer; Signaling by Activin; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; TGFBR1 KD Mutants in Cancer; RUNX3 regulates CDKN1A transcription,65,High,1
Q9NWZ5,Uridine-cytidine kinase-like 1 OS=Homo sapiens OX=9606 GN=UCKL1 PE=1 SV=2,0,22.519,14,6,29,6,548,61.1,7.36,11244,0,6,1,metabolic process,cytoplasm;cytosol;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00485, Pf07931, Pf13207, Pf14681",54963,ENSG00000198276.15,UCKL1,20,Drug metabolism - other enzymes; Metabolic pathways; Pyrimidine metabolism,,Pyrimidine salvage,7,High,1
O14498,Immunoglobulin superfamily containing leucine-rich repeat protein OS=Homo sapiens OX=9606 GN=ISLR PE=2 SV=1,0,22.468,12,4,16,4,428,46,5.15,7344,,4,,transport,extracellular;organelle lumen,protein binding,"Pf07679, Pf13855",3671,ENSG00000129009.12,ISLR,15,,,Platelet degranulation,4,High,1
O60503,Adenylate cyclase type 9 OS=Homo sapiens OX=9606 GN=ADCY9 PE=1 SV=4,0,22.44,6,6,16,6,1353,150.6,7.34,5461,,6,,metabolic process;regulation of biological process;response to stimulus,membrane,catalytic activity;metal ion binding;nucleotide binding,Pf00211,115,ENSG00000162104.9,ADCY9,16,Purine metabolism; Retrograde endocannabinoid signaling; Longevity regulating pathway; Ovarian steroidogenesis; HTLV-I infection; cAMP signaling pathway; Pathways in cancer; Vibrio cholerae infection; Progesterone-mediated oocyte maturation; Vasopressin-regulated water reabsorption; Phospholipase D signaling pathway; Melanogenesis; Cholinergic synapse; Vascular smooth muscle contraction; Gap junction; GnRH signaling pathway; Endocrine and other factor-regulated calcium reabsorption; Salivary secretion; Dilated cardiomyopathy; Thyroid hormone synthesis; Estrogen signaling pathway; Oxytocin signaling pathway; Gastric acid secretion; Glutamatergic synapse; Adrenergic signaling in cardiomyocytes; Chemokine signaling pathway; Rap1 signaling pathway; Oocyte meiosis; Platelet activation; Longevity regulating pathway - multiple species; Insulin secretion; Endocrine resistance; cGMP-PKG signaling pathway; Aldosterone synthesis and secretion; Calcium signaling pathway; Morphine addiction; Inflammatory mediator regulation of TRP channels; Bile secretion; Pancreatic secretion; Regulation of lipolysis in adipocytes; Circadian entrainment; GABAergic synapse,Myometrial Relaxation and Contraction Pathways; G Protein Signaling Pathways; Chemokine signaling pathway; Calcium Regulation in the Cardiac Cell,Adenylate cyclase activating pathway; G alpha (z) signalling events; G alpha (s) signalling events; Hedgehog 'off' state; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation in glucagon signalling; PKA activation; Adenylate cyclase inhibitory pathway,80,High,1
Q8N9V3,"WD repeat, SAM and U-box domain-containing protein 1 OS=Homo sapiens OX=9606 GN=WDSUB1 PE=1 SV=3",0,22.423,15,6,21,6,476,52.8,6.37,9644,,6,,metabolic process,nucleus,catalytic activity;DNA binding;metal ion binding;protein binding,"Pf00400, Pf00536, Pf02198, Pf04564, Pf07647, Pf11768, Pf11789",151525,,WDSUB1,2,,,,0,High,1
P07711,Cathepsin L1 OS=Homo sapiens OX=9606 GN=CTSL PE=1 SV=2,0,22.384,15,3,28,3,333,37.5,5.45,12195,,3,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,extracellular;nucleus;organelle lumen;vacuole,catalytic activity;protein binding,"Pf00112, Pf08246",1514,ENSG00000135047.14,CTSL; CTSL1,9,Apoptosis; Antigen processing and presentation; Phagosome; Proteoglycans in cancer; Lysosome; Rheumatoid arthritis,Primary Focal Segmental Glomerulosclerosis FSGS,Collagen degradation; RUNX1 regulates transcription of genes involved in differentiation of keratinocytes; Assembly of collagen fibrils and other multimeric structures; Endosomal/Vacuolar pathway; MHC class II antigen presentation; Trafficking and processing of endosomal TLR,26,High,1
Q15286,Ras-related protein Rab-35 OS=Homo sapiens OX=9606 GN=RAB35 PE=1 SV=1,0,22.366,16,3,19,3,201,23,8.29,8416,,3,,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytosol;endosome;membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding,"Pf00006, Pf00025, Pf00071, Pf00735, Pf01926, Pf04670, Pf08477, Pf13191",11021,ENSG00000111737.11,RAB35,12,Endocytosis,,TBC/RABGAPs; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation,9,High,1
P28906,Hematopoietic progenitor cell antigen CD34 OS=Homo sapiens OX=9606 GN=CD34 PE=1 SV=2,0,22.357,13,2,5,2,385,40.7,7.37,2576,,2,,cell communication;cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;regulation of biological process;response to stimulus,cell surface;cytoplasm;extracellular;membrane;vacuole,protein binding,Pf06365,947,ENSG00000174059.16,CD34,1,Hematopoietic cell lineage; Cell adhesion molecules (CAMs),,Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell,5,High,1
Q14168,MAGUK p55 subfamily member 2 OS=Homo sapiens OX=9606 GN=MPP2 PE=1 SV=3,0,22.335,12,6,14,4,576,64.5,6.77,5436,,6,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;membrane,catalytic activity;protein binding,"Pf00018, Pf00595, Pf00625, Pf02828, Pf07653, Pf13180, Pf14685",4355,,MPP2,17,,,,0,High,1
O60240,Perilipin-1 OS=Homo sapiens OX=9606 GN=PLIN1 PE=1 SV=2,0,22.333,16,5,15,5,522,56,6.42,5613,,5,,metabolic process,cytosol;endoplasmic reticulum,,Pf03036,5346,ENSG00000166819.11,PLIN1,15,PPAR signaling pathway; Regulation of lipolysis in adipocytes,Adipogenesis; PPAR signaling pathway,Triglyceride catabolism; Transcriptional regulation of white adipocyte differentiation,10,High,1
O95057,GTP-binding protein Di-Ras1 OS=Homo sapiens OX=9606 GN=DIRAS1 PE=1 SV=1,0,22.319,27,5,17,4,198,22.3,8.72,6101,1.65,5,1,regulation of biological process;response to stimulus,membrane,catalytic activity;nucleotide binding;protein binding,"Pf00071, Pf08477",148252,ENSG00000176490.4,DIRAS1,19,,,,0,High,1
P04921,Glycophorin-C OS=Homo sapiens OX=9606 GN=GYPC PE=1 SV=1,0,22.273,20,1,8,1,128,13.8,4.84,4411,,1,,cellular component movement,cytoskeleton;membrane,protein binding;receptor activity,,2995,ENSG00000136732.14,GYPC,2,Malaria,,Cell surface interactions at the vascular wall,3,High,1
Q9NRW4,Dual specificity protein phosphatase 22 OS=Homo sapiens OX=9606 GN=DUSP22 PE=1 SV=1,0,22.252,21,3,21,3,184,20.9,8.1,10014,,3,,cell death;cell proliferation;development;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,catalytic activity,"Pf00102, Pf00782",56940,ENSG00000112679.14,DUSP22,6,,,,0,High,1
Q9NWT6,Hypoxia-inducible factor 1-alpha inhibitor OS=Homo sapiens OX=9606 GN=HIF1AN PE=1 SV=2,0,22.249,22,5,8,5,349,40.3,5.57,3233,,5,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;protein binding,"Pf02373, Pf08007, Pf13621",55662,ENSG00000166135.13,HIF1AN,10,,miR-148a/miR-31/FIH1/HIF1alpha-Notch signaling in glioblastoma; Photodynamic therapy-induced HIF-1 survival signaling,Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha,7,High,1
Q9BVL4,"Protein adenylyltransferase SelO, mitochondrial OS=Homo sapiens OX=9606 GN=SELENOO PE=1 SV=3",0,22.241,6,3,12,3,669,73.4,5.97,6495,,3,,,mitochondrion,,Pf02696,83642,ENSG00000073169.13,SELO; SELENOO,22,,Selenium Micronutrient Network; Selenium Metabolism and Selenoproteins,,2,High,1
Q6GMV2,SET and MYND domain-containing protein 5 OS=Homo sapiens OX=9606 GN=SMYD5 PE=1 SV=2,0,22.235,17,5,47,5,418,47.3,5.05,18459,9.11,4,1,metabolic process,,catalytic activity;metal ion binding;protein binding,Pf00856,10322,ENSG00000135632.11,SMYD5,2,,Histone Modifications,,1,High,1
P01034,Cystatin-C OS=Homo sapiens OX=9606 GN=CST3 PE=1 SV=1,0,22.227,12,3,11,3,146,15.8,8.75,6971,,3,,cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;endosome;extracellular;membrane;organelle lumen;vacuole,enzyme regulator activity;protein binding,Pf00031,1471,ENSG00000101439.8,CST3,20,Salivary secretion,,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Neutrophil degranulation; Amyloid fiber formation,9,High,1
Q9NQ29,Putative RNA-binding protein Luc7-like 1 OS=Homo sapiens OX=9606 GN=LUC7L PE=1 SV=1,0,22.223,13,4,25,2,371,43.7,9.92,11726,0,4,1,cell organization and biogenesis;regulation of biological process,nucleus;spliceosomal complex,protein binding;RNA binding,Pf03194,55692,ENSG00000007392.16,LUC7L,16,,,,0,High,1
Q9BTE1,Dynactin subunit 5 OS=Homo sapiens OX=9606 GN=DCTN5 PE=1 SV=1,0,22.217,14,3,36,3,182,20.1,8.02,18884,,3,,transport,chromosome;cytoplasm;cytoskeleton;cytosol;membrane,protein binding,Pf00132,84516,ENSG00000166847.9,DCTN5,16,Vasopressin-regulated water reabsorption,,COPI-independent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR),18,High,1
P0CG22,Putative dehydrogenase/reductase SDR family member 4-like 1 OS=Homo sapiens OX=9606 GN=DHRS4L1 PE=5 SV=1,0,22.208,20,5,58,1,281,30.6,9.77,25831,0,5,1,metabolic process,,catalytic activity,"Pf00106, Pf13561",728635,,DHRS4L1,14,,,,0,High,1
P42677,40S ribosomal protein S27 OS=Homo sapiens OX=9606 GN=RPS27 PE=1 SV=3,0,22.202,29,2,55,1,84,9.5,9.45,28600,2.08,2,1,cell organization and biogenesis;cell proliferation;metabolic process;transport,cytosol;nucleus;ribosome,DNA binding;metal ion binding;protein binding;RNA binding;structural molecule activity,Pf01667,6232,ENSG00000177954.11,RPS27,1,Ribosome,Cytoplasmic Ribosomal Proteins,"Peptide chain elongation; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Separation of Sister Chromatids; SRP-dependent cotranslational protein targeting to membrane; Eukaryotic Translation Termination; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Resolution of Sister Chromatid Cohesion; Major pathway of rRNA processing in the nucleolus and cytosol; RHO GTPases Activate Formins; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits",54,High,1
Q9HCN8,Stromal cell-derived factor 2-like protein 1 OS=Homo sapiens OX=9606 GN=SDF2L1 PE=1 SV=2,0,22.181,27,3,14,3,221,23.6,7.03,5238,,3,,metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;membrane;organelle lumen,catalytic activity;protein binding,Pf02815,23753,ENSG00000128228.4,SDF2L1,22,,,,0,High,1
Q5J8M3,ER membrane protein complex subunit 4 OS=Homo sapiens OX=9606 GN=EMC4 PE=1 SV=2,0,22.18,28,4,16,4,183,20.1,8.62,7493,0,4,1,cell death;metabolic process,membrane,,Pf06417,51234,ENSG00000128463.12,EMC4,15,,,,0,High,1
Q8TEA8,D-aminoacyl-tRNA deacylase 1 OS=Homo sapiens OX=9606 GN=DTD1 PE=1 SV=2,0,22.175,28,3,8,3,209,23.4,8.24,5466,,3,,metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;DNA binding;metal ion binding;RNA binding,Pf02580,92675,ENSG00000125821.11,DTD1,20,,,,0,High,1
Q8N6R0,eEF1A lysine and N-terminal methyltransferase OS=Homo sapiens OX=9606 GN=EEF1AKNMT PE=1 SV=1,0,22.166,6,4,23,4,699,78.7,6.73,10755,,4,,metabolic process,,catalytic activity;protein binding,"Pf01564, Pf08241, Pf12847, Pf13649, Pf13659, Pf13847",51603,ENSG00000010165.19,METTL13,1,,,,0,High,1
O43924,"Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta OS=Homo sapiens OX=9606 GN=PDE6D PE=1 SV=1",0,22.159,33,4,19,4,150,17.4,5.67,7737,,4,,regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane,catalytic activity;enzyme regulator activity;protein binding,Pf05351,5147,ENSG00000156973.13,PDE6D,2,Purine metabolism,,ARL13B-mediated ciliary trafficking of INPP5E,5,High,1
Q9UP65,Cytosolic phospholipase A2 gamma OS=Homo sapiens OX=9606 GN=PLA2G4C PE=1 SV=2,0,22.153,13,4,16,4,541,60.9,6.93,4379,8.41,3,2,defense response;metabolic process;regulation of biological process;response to stimulus,cytosol;membrane,catalytic activity,Pf01735,8605,ENSG00000105499.13,PLA2G4C,19,Oxytocin signaling pathway; GnRH signaling pathway; Phospholipase D signaling pathway; Inflammatory mediator regulation of TRP channels; Vascular smooth muscle contraction; Long-term depression; Arachidonic acid metabolism; Platelet activation; VEGF signaling pathway; alpha-Linolenic acid metabolism; Glutamatergic synapse; Fc epsilon RI signaling pathway; Serotonergic synapse; Choline metabolism in cancer; Metabolic pathways; Ras signaling pathway; Glycerophospholipid metabolism; Linoleic acid metabolism; MAPK signaling pathway; Ovarian steroidogenesis; Ether lipid metabolism,,Acyl chain remodelling of PI; Hydrolysis of LPC; Hydrolysis of LPE; Acyl chain remodelling of PE; Acyl chain remodelling of PC,30,High,1
Q9Y3A6,Transmembrane emp24 domain-containing protein 5 OS=Homo sapiens OX=9606 GN=TMED5 PE=1 SV=1,0,22.144,18,3,18,3,229,26,4.84,7800,,3,,cell organization and biogenesis;transport,endoplasmic reticulum;Golgi;membrane,protein binding,Pf01105,50999,ENSG00000117500.12,TMED5,1,,,WNT ligand biogenesis and trafficking,3,High,1
Q96ST3,Paired amphipathic helix protein Sin3a OS=Homo sapiens OX=9606 GN=SIN3A PE=1 SV=2,0,22.133,5,5,14,5,1273,145.1,7.25,4900,,5,,cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,chromosome;nucleus,catalytic activity;DNA binding;protein binding;RNA binding,"Pf02671, Pf08295",25942,ENSG00000169375.15,SIN3A,15,Huntington's disease; Thyroid hormone signaling pathway; Transcriptional misregulation in cancer,Androgen receptor signaling pathway; Retinoblastoma (RB) in Cancer; Mecp2 and Associated Rett Syndrome; TGF-beta Signaling Pathway; Hedgehog Signaling Pathway,RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha); NoRC negatively regulates rRNA expression; Factors involved in megakaryocyte development and platelet production,21,High,1
Q14690,Protein RRP5 homolog OS=Homo sapiens OX=9606 GN=PDCD11 PE=1 SV=3,0,22.132,3,6,14,6,1871,208.6,8.87,5143,,6,,metabolic process,cytosol;nucleus,protein binding;RNA binding,"Pf00575, Pf13424, Pf13432",22984,ENSG00000148843.13,PDCD11,10,,,Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol,5,High,1
Q684P5,Rap1 GTPase-activating protein 2 OS=Homo sapiens OX=9606 GN=RAP1GAP2 PE=1 SV=2,0,22.11,13,7,14,7,730,80,6.67,5128,,7,,cell organization and biogenesis;regulation of biological process,cytoplasm;cytosol;membrane,enzyme regulator activity;protein binding,Pf02145,23108,ENSG00000132359.14,RAP1GAP2,17,,,Rap1 signalling,3,High,1
Q99622,Protein C10 OS=Homo sapiens OX=9606 GN=C12orf57 PE=1 SV=1,0,22.099,40,3,15,3,126,13.2,5.14,6603,,3,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm,,Pf14974,113246,ENSG00000111678.10,C12orf57,12,,,,0,High,1
Q7Z422,SUZ domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SZRD1 PE=1 SV=1,0,22.086,34,3,15,3,152,17,8.95,6356,,3,,,,,"Pf12752, Pf12901",26099,ENSG00000055070.16,SZRD1,1,,,,0,High,1
Q8IUR0,Trafficking protein particle complex subunit 5 OS=Homo sapiens OX=9606 GN=TRAPPC5 PE=1 SV=1,0,22.063,25,5,41,5,188,20.8,9.66,16916,,5,,cell organization and biogenesis;transport,cytosol;endoplasmic reticulum;Golgi;membrane,protein binding,Pf04051,126003,ENSG00000181029.8,TRAPPC5,19,,,RAB GEFs exchange GTP for GDP on RABs; COPII (Coat Protein 2) Mediated Vesicle Transport,10,High,1
Q96FN4,Copine-2 OS=Homo sapiens OX=9606 GN=CPNE2 PE=1 SV=3,0,22.062,9,4,61,3,548,61.2,6.07,36074,,4,,response to stimulus,cytoplasm;membrane;nucleus,protein binding,"Pf00168, Pf07002, Pf10138",221184,ENSG00000140848.16,CPNE2,16,,,,0,High,1
Q96EH3,Mitochondrial assembly of ribosomal large subunit protein 1 OS=Homo sapiens OX=9606 GN=MALSU1 PE=1 SV=1,0,22.038,12,2,23,2,234,26.2,5.49,11270,,2,,regulation of biological process,cytosol;mitochondrion;organelle lumen,protein binding,Pf02410,115416,ENSG00000156928.4,MALSU1,7,,,,0,High,1
P50440,"Glycine amidinotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=GATM PE=1 SV=1",0,22.036,20,6,18,6,423,48.4,8.05,5338,,6,,development;metabolic process;response to stimulus,cytoplasm;membrane;mitochondrion,catalytic activity,Pf02274,2628,ENSG00000171766.15,GATM,15,"Glycine, serine and threonine metabolism; Metabolic pathways; Arginine and proline metabolism",Urea cycle and metabolism of amino groups,Creatine metabolism,8,High,1
O95248,Myotubularin-related protein 5 OS=Homo sapiens OX=9606 GN=SBF1 PE=1 SV=4,0,22.036,5,6,15,6,1868,208.3,6.9,5270,,6,,,,,,,,,,,,,0,High,1
P0DJ07,"Protein PET100 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=PET100 PE=1 SV=1",0,22.031,23,3,48,3,73,9.1,6.77,21476,,3,,cell organization and biogenesis,membrane;mitochondrion,protein binding,Pf09803,100131801,ENSG00000229833.9,PET100,19,,,,0,High,1
P36954,DNA-directed RNA polymerase II subunit RPB9 OS=Homo sapiens OX=9606 GN=POLR2I PE=1 SV=1,0,22.011,39,3,14,3,125,14.5,5.14,5686,,3,,metabolic process;regulation of biological process;response to stimulus,nucleus,catalytic activity;metal ion binding,"Pf01096, Pf02150",5438,ENSG00000105258.8,POLR2I,19,RNA polymerase; Huntington's disease; Metabolic pathways; Purine metabolism; Epstein-Barr virus infection; Pyrimidine metabolism,Eukaryotic Transcription Initiation,Signaling by FGFR2 IIIa TM; RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Formation of HIV-1 elongation complex containing HIV-1 Tat; MicroRNA (miRNA) biogenesis; Formation of the HIV-1 Early Elongation Complex; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; TP53 Regulates Transcription of DNA Repair Genes; Transcriptional regulation by small RNAs; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; RNA Polymerase II HIV Promoter Escape; Formation of HIV elongation complex in the absence of HIV Tat; Transcriptional regulation of pluripotent stem cells; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; Formation of TC-NER Pre-Incision Complex; Pausing and recovery of HIV elongation; RNA Polymerase II Promoter Escape; HIV elongation arrest and recovery; RNA Pol II CTD phosphorylation and interaction with CE; Viral Messenger RNA Synthesis; RNA Polymerase II Transcription Initiation; mRNA Capping; Dual incision in TC-NER; PIWI-interacting RNA (piRNA) biogenesis; Pausing and recovery of Tat-mediated HIV elongation; Formation of the Early Elongation Complex,75,High,1
P57740,Nuclear pore complex protein Nup107 OS=Homo sapiens OX=9606 GN=NUP107 PE=1 SV=1,0,21.996,8,6,24,6,925,106.3,5.43,8803,0,6,1,cell organization and biogenesis;metabolic process;regulation of biological process;transport,chromosome;cytosol;membrane;nucleus,protein binding;structural molecule activity;transporter activity,Pf04121,57122,ENSG00000111581.9,NUP107,12,RNA transport,Gastric Cancer Network 1,Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; Separation of Sister Chromatids; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Resolution of Sister Chromatid Cohesion; Transport of Ribonucleoproteins into the Host Nucleus; RHO GTPases Activate Formins; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins,78,High,1
O75382,Tripartite motif-containing protein 3 OS=Homo sapiens OX=9606 GN=TRIM3 PE=1 SV=2,0,21.976,9,6,19,6,744,80.8,7.83,6746,,6,,metabolic process;transport,cytoplasm;endosome;Golgi,catalytic activity;metal ion binding;protein binding,"Pf00097, Pf00435, Pf00630, Pf00643, Pf01436, Pf04156, Pf08450, Pf11740, Pf12128, Pf12861, Pf13445, Pf13514, Pf13639, Pf13920, Pf13923, Pf14634, Pf15227",10612,ENSG00000110171.19,TRIM3,11,,,Interferon gamma signaling,4,High,1
P09913,Interferon-induced protein with tetratricopeptide repeats 2 OS=Homo sapiens OX=9606 GN=IFIT2 PE=1 SV=1,0,21.976,16,7,17,6,472,54.6,6.76,6274,,7,,cell death;cell organization and biogenesis;defense response;regulation of biological process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum,protein binding;RNA binding,"Pf13414, Pf13424",3433,ENSG00000119922.9,IFIT2,10,,Type II interferon signaling (IFNG),Interferon alpha/beta signaling,5,High,1
Q8WUA7,TBC1 domain family member 22A OS=Homo sapiens OX=9606 GN=TBC1D22A PE=1 SV=2,0,21.974,10,4,15,4,517,59.1,5.97,5816,0,4,1,regulation of biological process;transport,,enzyme regulator activity;protein binding,Pf00566,25771,ENSG00000054611.13,TBC1D22A,22,,,,0,High,1
P60468,Protein transport protein Sec61 subunit beta OS=Homo sapiens OX=9606 GN=SEC61B PE=1 SV=2,0,21.958,38,3,67,3,96,10,11.56,36744,,3,,metabolic process;transport,cytosol;endoplasmic reticulum;membrane,protein binding;RNA binding;transporter activity,Pf03911,10952,ENSG00000106803.9,SEC61B,9,Vibrio cholerae infection; Protein processing in endoplasmic reticulum; Phagosome; Protein export,,ER-Phagosome pathway; XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane,15,High,1
P01040,Cystatin-A OS=Homo sapiens OX=9606 GN=CSTA PE=1 SV=1,0,21.953,61,6,19,6,98,11,5.5,6271,,6,,cell death;cell differentiation;metabolic process;regulation of biological process,cytoplasm;cytoskeleton;cytosol,enzyme regulator activity;protein binding;structural molecule activity,Pf00031,1475,ENSG00000121552.3,CSTA,3,,,Formation of the cornified envelope,3,High,1
Q13191,E3 ubiquitin-protein ligase CBL-B OS=Homo sapiens OX=9606 GN=CBLB PE=1 SV=2,0,21.951,7,5,19,5,982,109.4,7.88,7242,,5,,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus,catalytic activity;metal ion binding;protein binding;signal transducer activity,"Pf00097, Pf00627, Pf02262, Pf02761, Pf02762, Pf13639, Pf13920, Pf13923, Pf14447, Pf14634, Pf15227",868,ENSG00000114423.18,CBLB,3,Ubiquitin mediated proteolysis; ErbB signaling pathway; T cell receptor signaling pathway; Bacterial invasion of epithelial cells; Pathways in cancer; Chronic myeloid leukemia; Insulin signaling pathway; Measles; Endocytosis; Proteoglycans in cancer,Angiopoietin Like Protein 8 Regulatory Pathway; EGF/EGFR Signaling Pathway; Insulin Signaling; T-Cell antigen Receptor (TCR)  Signaling Pathway,Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Antigen processing: Ubiquitination & Proteasome degradation,20,High,1
Q7Z3K3,Pogo transposable element with ZNF domain OS=Homo sapiens OX=9606 GN=POGZ PE=1 SV=2,0,21.929,6,5,16,5,1410,155.2,7.4,4996,,5,,cell division;cell organization and biogenesis,chromosome;cytoplasm;cytosol;nucleus,DNA binding;metal ion binding;protein binding,"Pf03184, Pf03221",23126,ENSG00000143442.21,POGZ,1,,,,0,High,1
Q9NX36,DnaJ homolog subfamily C member 28 OS=Homo sapiens OX=9606 GN=DNAJC28 PE=1 SV=2,0,21.913,10,3,11,3,388,45.8,9.55,5472,,3,,cell organization and biogenesis;transport,,protein binding,"Pf00226, Pf09350",54943,ENSG00000262911.5; ENSG00000177692.11,DNAJC28,21; CHR_HSCHR21_4_CTG1_1,,,,0,High,1
Q9BYC2,"Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial OS=Homo sapiens OX=9606 GN=OXCT2 PE=2 SV=2",0,21.906,5,3,206,1,517,56.1,7.14,79862,0,2,2,metabolic process,mitochondrion;organelle lumen,catalytic activity,Pf01144,64064,ENSG00000198754.5,OXCT2,1,"Synthesis and degradation of ketone bodies; Valine, leucine and isoleucine degradation; Butanoate metabolism",,Utilization of Ketone Bodies,7,High,1
O95630,STAM-binding protein OS=Homo sapiens OX=9606 GN=STAMBP PE=1 SV=1,0,21.875,12,4,15,4,424,48,6.29,5871,,4,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endosome;membrane;nucleus,catalytic activity;metal ion binding;protein binding,"Pf01398, Pf04212, Pf08969",10617,ENSG00000124356.15,STAMBP,2,Endocytosis,EGF/EGFR Signaling Pathway,Metalloprotease DUBs,6,High,1
Q8IZP0,Abl interactor 1 OS=Homo sapiens OX=9606 GN=ABI1 PE=1 SV=4,0,21.854,11,4,24,3,508,55,7.06,10333,,4,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;nucleus,enzyme regulator activity;protein binding,"Pf00018, Pf07653, Pf07815, Pf14604",10006,ENSG00000136754.16,ABI1,10,,EGF/EGFR Signaling Pathway,Regulation of actin dynamics for phagocytic cup formation; VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs,12,High,1
Q9NUQ6,SPATS2-like protein OS=Homo sapiens OX=9606 GN=SPATS2L PE=1 SV=2,0,21.848,11,4,11,4,558,61.7,9.64,4261,,4,,,cytoplasm;cytosol;nucleus,protein binding;RNA binding,Pf07139,26010,ENSG00000196141.13,SPATS2L,2,,,,0,High,1
Q9BQC6,"Ribosomal protein 63, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL57 PE=1 SV=1",0,21.84,20,2,30,2,102,12.3,11.44,12826,,2,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,structural molecule activity,Pf14978,78988,ENSG00000173141.4,MRP63; MRPL57,13,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
Q9BQA9,Cytochrome b-245 chaperone 1 OS=Homo sapiens OX=9606 GN=CYBC1 PE=1 SV=1,0,21.827,17,2,34,2,187,20.8,6.8,13572,,2,,,membrane,protein binding,Pf15169,79415,ENSG00000178927.17,C17orf62,17,,,,0,High,1
Q70IA6,MOB kinase activator 2 OS=Homo sapiens OX=9606 GN=MOB2 PE=1 SV=1,0,21.82,17,5,17,5,237,26.9,6.79,8310,,5,,cell organization and biogenesis;regulation of biological process,cytoplasm;cytosol;nucleus,metal ion binding;protein binding,Pf03637,81532,,MOB2,11,,,,0,High,1
P11474,Steroid hormone receptor ERR1 OS=Homo sapiens OX=9606 GN=ESRRA PE=1 SV=3,0,21.805,17,5,18,5,423,45.5,6.38,6576,,5,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoskeleton;nucleus,DNA binding;metal ion binding;protein binding;receptor activity;signal transducer activity,"Pf00104, Pf00105",2101,ENSG00000173153.13,ESRRA,11,,Energy Metabolism; Nuclear Receptors; Preimplantation Embryo; Mitochondrial Gene Expression,Regulation of RUNX2 expression and activity; Transcriptional activation of mitochondrial biogenesis; Nuclear Receptor transcription pathway; PPARA activates gene expression,17,High,1
Q9BUH6,Protein PAXX OS=Homo sapiens OX=9606 GN=PAXX PE=1 SV=2,0,21.794,20,4,24,4,204,21.6,5.48,11080,,4,,metabolic process;response to stimulus,nucleus,protein binding;structural molecule activity,Pf15384,286257,ENSG00000148362.10,C9orf142; PAXX,9,,,,0,High,1
O14775-2,Isoform 2 of Guanine nucleotide-binding protein subunit beta-5 OS=Homo sapiens OX=9606 GN=GNB5,0,21.789,14,4,13,4,353,38.7,6.06,4154,8.44,3,1,metabolic process;regulation of biological process;response to stimulus,cytosol;membrane;nucleus,catalytic activity;enzyme regulator activity;protein binding;signal transducer activity,Pf00400,10681,ENSG00000069966.18,GNB5,15,,Endothelin Pathways; Corticotropin-releasing hormone signaling pathway; Myometrial Relaxation and Contraction Pathways; G Protein Signaling Pathways; Chemokine signaling pathway; Calcium Regulation in the Cardiac Cell,,6,High,1
Q9HCE6,Rho guanine nucleotide exchange factor 10-like protein OS=Homo sapiens OX=9606 GN=ARHGEF10L PE=1 SV=4,0,21.768,4,4,18,4,1279,140.3,5.94,6509,,4,,,,,,,,,,,,,0,High,1
P62312,U6 snRNA-associated Sm-like protein LSm6 OS=Homo sapiens OX=9606 GN=LSM6 PE=1 SV=1,0,21.767,55,5,36,5,80,9.1,9.58,15541,,5,,metabolic process,cytoplasm;cytosol;nucleus;spliceosomal complex,protein binding;RNA binding,Pf01423,11157,ENSG00000164167.10,LSM6,4,Spliceosome; RNA degradation,,mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease,8,High,1
Q8TB61,Adenosine 3'-phospho 5'-phosphosulfate transporter 1 OS=Homo sapiens OX=9606 GN=SLC35B2 PE=1 SV=1,0,21.751,11,6,29,6,432,47.5,9.16,11272,,6,,metabolic process;regulation of biological process;response to stimulus;transport,Golgi;membrane,signal transducer activity;transporter activity,Pf08449,347734,ENSG00000157593.18,SLC35B2,6,,,Transport and synthesis of PAPS; Transport of nucleotide sugars,11,High,1
P29372,DNA-3-methyladenine glycosylase OS=Homo sapiens OX=9606 GN=MPG PE=1 SV=3,0,21.706,20,5,10,5,298,32.8,9.57,4948,,5,,metabolic process;response to stimulus,cytoplasm;mitochondrion;nucleus,catalytic activity;DNA binding;protein binding,Pf02245,4350,ENSG00000103152.11,MPG,16,Base excision repair,,Recognition and association of DNA glycosylase with site containing an affected purine; Cleavage of the damaged purine; Displacement of DNA glycosylase by APEX1,9,High,1
O60443,Gasdermin-E OS=Homo sapiens OX=9606 GN=GSDME PE=1 SV=2,0,21.695,12,5,20,5,496,54.5,5.17,7041,1.77,5,1,cell death;cell differentiation;regulation of biological process,cytoplasm;cytosol;membrane,,Pf04598,1687,ENSG00000105928.13,DFNA5; GSDME,7,,,,0,High,1
Q00534,Cyclin-dependent kinase 6 OS=Homo sapiens OX=9606 GN=CDK6 PE=1 SV=1,0,21.694,21,4,15,4,326,36.9,6.46,6612,,4,,cell differentiation;cell division;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf07714",1021,ENSG00000105810.9,CDK6,7,Viral carcinogenesis; Small cell lung cancer; Pathways in cancer; MicroRNAs in cancer; PI3K-Akt signaling pathway; p53 signaling pathway; Non-small cell lung cancer; Hepatitis B; Glioma; Breast cancer; Cell cycle; Chronic myeloid leukemia; Measles; Pancreatic cancer; Melanoma,miRNA Regulation of DNA Damage Response; miRNAs involved in DNA damage response; Cell Cycle; Metastatic brain tumor; Signaling Pathways in Glioblastoma; Retinoblastoma (RB) in Cancer; Wnt Signaling Pathway Netpath; G1 to S cell cycle control; DNA Damage Response,Regulation of RUNX1 Expression and Activity; Cyclin D associated events in G1; Oncogene Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Oxidative Stress Induced Senescence,40,High,1
Q9UNL2,Translocon-associated protein subunit gamma OS=Homo sapiens OX=9606 GN=SSR3 PE=1 SV=1,0,21.692,12,2,15,2,185,21.1,9.61,10545,,2,,cell organization and biogenesis;transport,endoplasmic reticulum;membrane,,Pf07074,6747,ENSG00000114850.6,SSR3,3,Protein processing in endoplasmic reticulum,,SRP-dependent cotranslational protein targeting to membrane,4,High,1
Q8N128,Protein FAM177A1 OS=Homo sapiens OX=9606 GN=FAM177A1 PE=1 SV=1,0,21.687,25,5,20,5,213,23.7,4.45,9017,,5,,,,,Pf14774,283635,ENSG00000151327.12,FAM177A1,14,,,,0,High,1
P82921,"28S ribosomal protein S21, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS21 PE=1 SV=3",0,21.681,39,3,43,3,87,10.7,9.92,21193,,3,,,,,,,,,,,,,0,High,1
O60669,Monocarboxylate transporter 2 OS=Homo sapiens OX=9606 GN=SLC16A7 PE=1 SV=2,0,21.665,10,5,35,5,478,52.2,9.31,15995,,5,,transport,membrane,transporter activity,"Pf00083, Pf07690",9194,ENSG00000118596.11,SLC16A7,12,,,Proton-coupled monocarboxylate transport,4,High,1
P34947,G protein-coupled receptor kinase 5 OS=Homo sapiens OX=9606 GN=GRK5 PE=1 SV=1,0,21.662,7,3,7,3,590,67.7,8.1,3436,,3,,cell death;cell differentiation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf00615, Pf07714",2869,ENSG00000198873.11,GRK5,10,Morphine addiction; Chemokine signaling pathway; Endocytosis,Myometrial Relaxation and Contraction Pathways; Chemokine signaling pathway; Calcium Regulation in the Cardiac Cell,G alpha (s) signalling events; Gastrin-CREB signalling pathway via PKC and MAPK,12,High,1
Q9UL26,Ras-related protein Rab-22A OS=Homo sapiens OX=9606 GN=RAB22A PE=1 SV=2,0,21.607,27,4,11,4,194,21.8,8.15,4163,,4,,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoskeleton;endosome;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00009, Pf00025, Pf00071, Pf04670, Pf08477",57403,ENSG00000124209.3,RAB22A,20,Endocytosis,,RAB geranylgeranylation,4,High,1
Q8IXT5,RNA-binding protein 12B OS=Homo sapiens OX=9606 GN=RBM12B PE=1 SV=2,0,21.6,4,4,13,4,1001,118,6.81,6300,0,4,1,,,protein binding;RNA binding,"Pf00076, Pf14259",389677,ENSG00000183808.11,RBM12B,8,,,,0,High,1
Q6R327,Rapamycin-insensitive companion of mTOR OS=Homo sapiens OX=9606 GN=RICTOR PE=1 SV=1,0,21.589,6,7,11,7,1708,192.1,7.47,3578,,7,,cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus,cytosol,enzyme regulator activity;protein binding,"Pf14663, Pf14664, Pf14665, Pf14666, Pf14668",253260,ENSG00000164327.12,RICTOR,5,mTOR signaling pathway,Target Of Rapamycin (TOR) Signaling; Oncostatin M Signaling Pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; EGF/EGFR Signaling Pathway,PIP3 activates AKT signaling; CD28 dependent PI3K/Akt signaling; Regulation of TP53 Degradation; VEGFR2 mediated vascular permeability; Constitutive Signaling by AKT1 E17K in Cancer,30,High,1
O95178,"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFB2 PE=1 SV=1",0,21.579,40,3,191,3,105,12.1,5.74,90668,15.89,2,2,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion,catalytic activity;metal ion binding;transporter activity,Pf14813,4708,ENSG00000090266.12,NDUFB2,7,Parkinson's disease; Oxidative phosphorylation; Huntington's disease; Metabolic pathways; Alzheimer's disease; Non-alcoholic fatty liver disease (NAFLD),Electron Transport Chain; Oxidative phosphorylation,Complex I biogenesis,13,High,1
P54922,[Protein ADP-ribosylarginine] hydrolase OS=Homo sapiens OX=9606 GN=ADPRH PE=1 SV=1,0,21.568,19,5,21,5,357,39.5,6.52,8094,,5,,metabolic process;regulation of biological process;transport,,catalytic activity;enzyme regulator activity;metal ion binding;protein binding,Pf03747,141,ENSG00000144843.11,ADPRH,3,,,,0,High,1
Q96CD0,F-box/LRR-repeat protein 8 OS=Homo sapiens OX=9606 GN=FBXL8 PE=1 SV=1,0,21.54,17,5,18,5,374,40.5,7.31,7388,,5,,metabolic process,cytosol,catalytic activity;protein binding,,55336,ENSG00000135722.8,FBXL8,16,,,Antigen processing: Ubiquitination & Proteasome degradation; Neddylation,7,High,1
P08069,Insulin-like growth factor 1 receptor OS=Homo sapiens OX=9606 GN=IGF1R PE=1 SV=1,0,21.536,4,6,16,3,1367,154.7,5.8,5581,,6,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,membrane,catalytic activity;nucleotide binding;protein binding;receptor activity;signal transducer activity,"Pf00041, Pf00069, Pf00757, Pf01030, Pf01826, Pf07714, Pf14843",3480,ENSG00000140443.13,IGF1R,15,AMPK signaling pathway; Melanoma; Progesterone-mediated oocyte maturation; Endocrine resistance; HIF-1 signaling pathway; Adherens junction; Focal adhesion; Prostate cancer; PI3K-Akt signaling pathway; FoxO signaling pathway; Oocyte meiosis; Endocytosis; mTOR signaling pathway; Breast cancer; Signaling pathways regulating pluripotency of stem cells; Proteoglycans in cancer; Rap1 signaling pathway; Ras signaling pathway; EGFR tyrosine kinase inhibitor resistance; Ovarian steroidogenesis; Long-term depression; Glioma; Longevity regulating pathway - multiple species; Transcriptional misregulation in cancer; Pathways in cancer; Longevity regulating pathway,MicroRNAs in cardiomyocyte hypertrophy; Human Thyroid Stimulating Hormone (TSH) signaling pathway; Signaling Pathways in Glioblastoma; Apoptosis; Focal Adhesion; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Endochondral Ossification; Insulin Signaling; Senescence and Autophagy in Cancer,IRS-related events triggered by IGF1R; SHC-related events triggered by IGF1R,42,High,1
Q92574,Hamartin OS=Homo sapiens OX=9606 GN=TSC1 PE=1 SV=2,0,21.519,5,4,21,4,1164,129.7,6.47,8212,,4,,cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,catalytic activity;motor activity;protein binding,"Pf00261, Pf01576, Pf02388, Pf02463, Pf03357, Pf04111, Pf04156, Pf04388, Pf04912, Pf05483, Pf05557, Pf07926, Pf08317, Pf10473, Pf12128, Pf12718, Pf12795, Pf13851, Pf13868, Pf14643, Pf14915, Pf14988",7248,ENSG00000165699.13,TSC1,9,PI3K-Akt signaling pathway; AMPK signaling pathway; Insulin signaling pathway; Longevity regulating pathway; Choline metabolism in cancer; mTOR signaling pathway; Phospholipase D signaling pathway,"AMP-activated Protein Kinase (AMPK) Signaling; Target Of Rapamycin (TOR) Signaling; Integrated Breast Cancer Pathway; Signaling Pathways in Glioblastoma; Nanoparticle triggered autophagic cell death; Wnt Signaling Pathway Netpath; BDNF-TrkB Signaling; 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression; Angiopoietin Like Protein 8 Regulatory Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Insulin Signaling",TBC/RABGAPs; Energy dependent regulation of mTOR by LKB1-AMPK; TP53 Regulates Metabolic Genes; Inhibition of TSC complex formation by PKB; Macroautophagy,33,High,1
Q8TDW0,Volume-regulated anion channel subunit LRRC8C OS=Homo sapiens OX=9606 GN=LRRC8C PE=1 SV=2,0,21.515,9,6,17,5,803,92.4,7.62,5084,,6,,cell differentiation;regulation of biological process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;membrane,protein binding;transporter activity,"Pf12534, Pf12799, Pf13855",84230,ENSG00000171488.14,LRRC8C,1,,,Miscellaneous transport and binding events,2,High,1
P53677,AP-3 complex subunit mu-2 OS=Homo sapiens OX=9606 GN=AP3M2 PE=2 SV=1,0,21.502,18,5,25,3,418,46.9,7.56,9378,,5,,cellular component movement;transport,Golgi;membrane,,Pf00928,10947,ENSG00000070718.11,AP3M2,8,Lysosome,,,1,High,1
Q4U2R6,"39S ribosomal protein L51, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL51 PE=1 SV=1",0,21.472,34,4,39,4,128,15.1,11.27,11181,,4,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,protein binding;structural molecule activity,Pf10244,51258,ENSG00000111639.7,MRPL51,12,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
Q71RC2,La-related protein 4 OS=Homo sapiens OX=9606 GN=LARP4 PE=1 SV=3,0,21.448,15,5,19,5,724,80.5,6.61,7184,,5,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;membrane,protein binding;RNA binding,"Pf05383, Pf14259",113251,ENSG00000161813.21,LARP4,12,,,,0,High,1
O43660,Pleiotropic regulator 1 OS=Homo sapiens OX=9606 GN=PLRG1 PE=1 SV=1,0,21.43,9,4,29,4,514,57.2,9.17,10862,,4,,cell organization and biogenesis;metabolic process;regulation of biological process,membrane;nucleus;spliceosomal complex,catalytic activity;protein binding,Pf00400,5356,ENSG00000171566.11,PLRG1,4,Spliceosome,,mRNA Splicing - Major Pathway,5,High,1
Q9UJF2,Ras GTPase-activating protein nGAP OS=Homo sapiens OX=9606 GN=RASAL2 PE=1 SV=2,0,21.414,8,7,21,6,1139,128.5,8.24,6975,,7,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,enzyme regulator activity;protein binding,"Pf00168, Pf00169, Pf00616, Pf12004",9462,ENSG00000075391.16,RASAL2,1,Ras signaling pathway,,Regulation of RAS by GAPs; Signaling by RAS mutants; Interleukin-20 family signaling,14,High,1
Q8TAF3,WD repeat-containing protein 48 OS=Homo sapiens OX=9606 GN=WDR48 PE=1 SV=1,0,21.407,13,6,17,6,677,76.2,7.03,6874,,6,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;endosome;nucleus;vacuole,catalytic activity;protein binding,"Pf00400, Pf11816",57599,ENSG00000114742.13,WDR48,3,Fanconi anemia pathway,,Ub-specific processing proteases,5,High,1
Q2NL82,Pre-rRNA-processing protein TSR1 homolog OS=Homo sapiens OX=9606 GN=TSR1 PE=1 SV=1,0,21.405,9,5,10,5,804,91.8,7.42,4832,,5,,cell organization and biogenesis;metabolic process,cytosol;nucleus,catalytic activity;nucleotide binding;RNA binding,"Pf04950, Pf08142",55720,ENSG00000167721.10,TSR1,17,,,Major pathway of rRNA processing in the nucleolus and cytosol,4,High,1
Q8IY95,Transmembrane protein 192 OS=Homo sapiens OX=9606 GN=TMEM192 PE=1 SV=1,0,21.4,13,3,9,3,271,30.9,7.99,3428,,3,,,endoplasmic reticulum;endosome;Golgi;membrane;nucleus;vacuole,protein binding,Pf14802,201931,ENSG00000170088.13,TMEM192,4,,,,0,High,1
Q96IV0,Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Homo sapiens OX=9606 GN=NGLY1 PE=1 SV=1,0,21.388,8,5,24,5,654,74.3,6.89,10081,,5,,metabolic process,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;protein binding,"Pf01841, Pf03835, Pf04721, Pf09409",55768,ENSG00000151092.16,NGLY1,3,Protein processing in endoplasmic reticulum,,N-glycan trimming in the ER and Calnexin/Calreticulin cycle,5,High,1
O95490,Adhesion G protein-coupled receptor L2 OS=Homo sapiens OX=9606 GN=ADGRL2 PE=1 SV=2,0,21.386,4,5,12,5,1459,163.2,6.43,2624,9.15,4,1,regulation of biological process;response to stimulus,membrane,receptor activity;signal transducer activity,"Pf00002, Pf01825, Pf02140, Pf02191, Pf02354, Pf02793, Pf12003",23266,ENSG00000117114.19,LPHN2; ADGRL2,1,,"GPCRs, Other; GPCRs, Class B Secretin-like",,2,High,1
O43903,Growth arrest-specific protein 2 OS=Homo sapiens OX=9606 GN=GAS2 PE=1 SV=1,0,21.367,20,5,15,5,313,34.9,8.47,4843,0,5,1,cell death;regulation of biological process,cytoplasm;cytoskeleton;cytosol;membrane,protein binding,"Pf00307, Pf02187",2620,ENSG00000148935.10,GAS2,11,,,Caspase-mediated cleavage of cytoskeletal proteins,5,High,1
Q8WVV4-1,Isoform 1 of Protein POF1B OS=Homo sapiens OX=9606 GN=POF1B,0,21.35,11,5,16,5,595,68.7,6.35,6389,,5,,cell organization and biogenesis,,protein binding,,79983,ENSG00000124429.17,POF1B,X,,,,0,High,1
Q8N129,Protein canopy homolog 4 OS=Homo sapiens OX=9606 GN=CNPY4 PE=2 SV=1,0,21.332,17,4,10,4,248,28.3,4.64,3962,,4,,regulation of biological process,extracellular,protein binding,Pf11938,245812,ENSG00000166997.7,CNPY4,7,,,,0,High,1
Q7Z5L7,Podocan OS=Homo sapiens OX=9606 GN=PODN PE=1 SV=2,0,21.31,15,7,22,7,613,68.9,6.99,6452,,7,,regulation of biological process;response to stimulus,cytoplasm;extracellular,enzyme regulator activity;protein binding,"Pf01462, Pf12799, Pf13855",127435,,PODN,1,,,,0,High,1
P29508,Serpin B3 OS=Homo sapiens OX=9606 GN=SERPINB3 PE=1 SV=2,0,21.297,10,4,49,3,390,44.5,6.81,25435,,4,,cell communication;regulation of biological process;transport,cytoplasm;extracellular;nucleus;organelle lumen,enzyme regulator activity;protein binding;receptor activity,Pf00079,6317,ENSG00000057149.15,SERPINB3,18,Amoebiasis,,Neutrophil degranulation,4,High,1
P61803,Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 OS=Homo sapiens OX=9606 GN=DAD1 PE=1 SV=3,0,21.274,28,3,20,3,113,12.5,7.08,10258,,3,,cell death;metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;membrane,catalytic activity,Pf02109,1603,ENSG00000129562.10,DAD1,14,N-Glycan biosynthesis; Protein processing in endoplasmic reticulum; Metabolic pathways,,Asparagine N-linked glycosylation,6,High,1
Q9ULC5,Long-chain-fatty-acid--CoA ligase 5 OS=Homo sapiens OX=9606 GN=ACSL5 PE=1 SV=1,0,21.267,7,4,179,1,683,75.9,6.92,91001,,4,,metabolic process;regulation of biological process,endoplasmic reticulum;membrane;mitochondrion;nucleus,catalytic activity;nucleotide binding,Pf00501,51703,ENSG00000197142.10,ACSL5,10,Fatty acid metabolism; PPAR signaling pathway; Metabolic pathways; Peroxisome; Adipocytokine signaling pathway; Fatty acid biosynthesis; Fatty acid degradation,Fatty Acid Beta Oxidation; Fatty Acid Biosynthesis; PPAR signaling pathway,Synthesis of very long-chain fatty acyl-CoAs,15,High,1
P78330,Phosphoserine phosphatase OS=Homo sapiens OX=9606 GN=PSPH PE=1 SV=2,0,21.264,20,4,29,4,225,25,5.69,11087,0,4,2,metabolic process;response to stimulus,cytoplasm;cytosol,catalytic activity;metal ion binding;protein binding,"Pf00702, Pf05822, Pf11019, Pf12710, Pf13419",5723,ENSG00000146733.13,PSPH,7,"Biosynthesis of amino acids; Glycine, serine and threonine metabolism; Metabolic pathways; Carbon metabolism",Trans-sulfuration and one carbon metabolism,Serine biosynthesis,9,High,1
P09668,Pro-cathepsin H OS=Homo sapiens OX=9606 GN=CTSH PE=1 SV=4,0,21.257,13,4,26,4,335,37.4,8.07,8670,,4,,cell death;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;extracellular;organelle lumen;vacuole,catalytic activity;enzyme regulator activity;protein binding;receptor activity;signal transducer activity,"Pf00112, Pf08246",1512,ENSG00000103811.15,CTSH,15,Apoptosis; Lysosome,,Surfactant metabolism; Neutrophil degranulation; MHC class II antigen presentation,9,High,1
Q9H7H0,"Methyltransferase-like protein 17, mitochondrial OS=Homo sapiens OX=9606 GN=METTL17 PE=1 SV=1",0,21.245,14,6,17,6,456,50.7,9.33,4131,3.63,6,1,metabolic process,mitochondrion;ribosome,catalytic activity;metal ion binding;protein binding,"Pf08241, Pf08242, Pf09243, Pf12847, Pf13847",64745,ENSG00000165792.17,METTL17,14,,,,0,High,1
Q96F85,CB1 cannabinoid receptor-interacting protein 1 OS=Homo sapiens OX=9606 GN=CNRIP1 PE=1 SV=1,0,21.237,35,5,48,5,164,18.6,7.94,15855,,5,,,,,"Pf09972, Pf15043",25927,ENSG00000119865.8,CNRIP1,2,,,,0,High,1
Q8N5G0,Small integral membrane protein 20 OS=Homo sapiens OX=9606 GN=SMIM20 PE=1 SV=3,0,21.228,34,3,45,3,67,7.7,9.86,18706,1.84,3,1,cell organization and biogenesis,membrane;mitochondrion,protein binding,Pf15061,389203,ENSG00000250317.8,C4orf52; SMIM20,4,,,,0,High,1
P86790,Vacuolar fusion protein CCZ1 homolog B OS=Homo sapiens OX=9606 GN=CCZ1B PE=1 SV=1,0,21.221,10,6,25,6,482,55.8,6.48,10346,,6,,transport,cytosol;membrane;vacuole,protein binding,Pf08217,51622; 221960,ENSG00000146574.15; ENSG00000122674.11,CCZ1; CCZ1B,7,,,RAB GEFs exchange GTP for GDP on RABs,4,High,1
Q9BY77,Polymerase delta-interacting protein 3 OS=Homo sapiens OX=9606 GN=POLDIP3 PE=1 SV=2,0,21.21,14,4,15,4,421,46.1,9.99,6363,,4,,metabolic process;regulation of biological process;transport,cytoplasm;cytosol;nucleus,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",84271,ENSG00000100227.17,POLDIP3,22,,,Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing,9,High,1
Q13043,Serine/threonine-protein kinase 4 OS=Homo sapiens OX=9606 GN=STK4 PE=1 SV=2,0,21.209,15,6,17,2,487,55.6,5.07,5749,0,6,2,cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf07714, Pf11629",6789,ENSG00000101109.11,STK4,20,FoxO signaling pathway; Pathways in cancer; Non-small cell lung cancer; Ras signaling pathway; MAPK signaling pathway,,Signaling by Hippo,7,High,1
P03923,NADH-ubiquinone oxidoreductase chain 6 OS=Homo sapiens OX=9606 GN=MT-ND6 PE=1 SV=2,0,21.198,15,3,36,3,174,18.6,4.22,21632,,3,,cell organization and biogenesis;metabolic process;response to stimulus;transport,membrane;mitochondrion,catalytic activity,,4541,ENSG00000198695.2,ND6,MT,Parkinson's disease; Oxidative phosphorylation; Metabolic pathways,Electron Transport Chain; Oxidative phosphorylation,Complex I biogenesis,10,High,1
Q9H0W5,Coiled-coil domain-containing protein 8 OS=Homo sapiens OX=9606 GN=CCDC8 PE=1 SV=2,0,21.19,13,5,9,5,538,59.3,8.63,3755,,5,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,protein binding,Pf14893,83987,ENSG00000169515.5,CCDC8,19,,,Neddylation,3,High,1
Q9P003,Protein cornichon homolog 4 OS=Homo sapiens OX=9606 GN=CNIH4 PE=1 SV=1,0,21.143,14,1,12,1,139,16.1,6.65,4960,,1,,transport,endoplasmic reticulum;membrane,protein binding,Pf03311,29097,ENSG00000143771.11,CNIH4,1,,,,0,High,1
Q99683,Mitogen-activated protein kinase kinase kinase 5 OS=Homo sapiens OX=9606 GN=MAP3K5 PE=1 SV=1,0,21.113,6,7,10,7,1374,154.4,5.78,3279,,7,,cell communication;cell death;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum,catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf07714, Pf13281, Pf14531",4217,ENSG00000197442.9,MAP3K5,6,Platinum drug resistance; Apoptosis; Sphingolipid signaling pathway; MAPK signaling pathway; TNF signaling pathway; Amyotrophic lateral sclerosis (ALS); Non-alcoholic fatty liver disease (NAFLD); Protein processing in endoplasmic reticulum; Neurotrophin signaling pathway,"Integrated Cancer pathway; TNF alpha Signaling Pathway; Corticotropin-releasing hormone signaling pathway; Amyotrophic lateral sclerosis (ALS); MAPK Signaling Pathway; ATM Signaling Network in Development and Disease; 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; p38 MAPK Signaling Pathway; Insulin Signaling",Oxidative Stress Induced Senescence,24,High,1
Q13023,A-kinase anchor protein 6 OS=Homo sapiens OX=9606 GN=AKAP6 PE=1 SV=3,0,21.088,3,5,8,5,2319,256.6,5.01,,9.48,,5,regulation of biological process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;membrane;nucleus,protein binding;structural molecule activity,Pf00435,9472,ENSG00000151320.10,AKAP6,14,,G Protein Signaling Pathways,,1,High,1
Q8TED1,Probable glutathione peroxidase 8 OS=Homo sapiens OX=9606 GN=GPX8 PE=1 SV=2,0,21.071,25,4,16,4,209,23.9,9.35,8317,,4,,metabolic process;response to stimulus,membrane;organelle lumen,antioxidant activity;catalytic activity,"Pf00255, Pf00578",493869,ENSG00000164294.13,GPX8,5,Glutathione metabolism; Thyroid hormone synthesis; Arachidonic acid metabolism,,Detoxification of Reactive Oxygen Species,6,High,1
Q9BUT9,MAPK regulated corepressor interacting protein 2 OS=Homo sapiens OX=9606 GN=MCRIP2 PE=1 SV=2,0,21.06,31,2,7,2,160,17.8,9.41,3262,,2,,,cytoplasm;nucleus,protein binding,Pf14799,84331,ENSG00000172366.19,FAM195A; MCRIP2,16,,,,0,High,1
Q9Y2T4,Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform OS=Homo sapiens OX=9606 GN=PPP2R2C PE=1 SV=4,0,21.056,7,2,21,1,447,51.5,6.37,10662,,2,,metabolic process;regulation of biological process,cytosol,catalytic activity;enzyme regulator activity;protein binding,,5522,ENSG00000074211.13,PPP2R2C,4,AMPK signaling pathway; Dopaminergic synapse; Sphingolipid signaling pathway; Hippo signaling pathway; Chagas disease (American trypanosomiasis); Hepatitis C; mRNA surveillance pathway; Adrenergic signaling in cardiomyocytes; Tight junction; PI3K-Akt signaling pathway,Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Wnt Signaling Pathway and Pluripotency; Glycogen Metabolism,,13,High,1
Q9H7B4,Histone-lysine N-methyltransferase SMYD3 OS=Homo sapiens OX=9606 GN=SMYD3 PE=1 SV=4,0,21.033,13,5,17,5,428,49.1,7.25,6732,,5,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,catalytic activity;DNA binding;metal ion binding;protein binding,"Pf00856, Pf01753",64754,ENSG00000185420.18,SMYD3,1,,Histone Modifications,PKMTs methylate histone lysines,4,High,1
Q9UKF6,Cleavage and polyadenylation specificity factor subunit 3 OS=Homo sapiens OX=9606 GN=CPSF3 PE=1 SV=1,0,21.026,10,5,13,5,684,77.4,5.6,5814,,5,,metabolic process;transport,nucleus,catalytic activity;metal ion binding;protein binding;RNA binding,"Pf00753, Pf07521, Pf10996, Pf11718, Pf12706, Pf13483",51692,ENSG00000119203.13,CPSF3,2,mRNA surveillance pathway,mRNA Processing,mRNA 3'-end processing; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA Splicing - Major Pathway; Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs,16,High,1
O15116,U6 snRNA-associated Sm-like protein LSm1 OS=Homo sapiens OX=9606 GN=LSM1 PE=1 SV=1,0,21.025,30,3,30,3,133,15.2,5.22,13133,,3,,metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,protein binding;RNA binding,Pf01423,27257,ENSG00000175324.9,LSM1,8,RNA degradation,,mRNA decay by 5' to 3' exoribonuclease,4,High,1
Q8WX92,Negative elongation factor B OS=Homo sapiens OX=9606 GN=NELFB PE=1 SV=1,0,21.005,14,4,6,4,580,65.7,6.13,3014,,4,,metabolic process;regulation of biological process,cytoplasm;nucleus,protein binding;RNA binding,Pf06209,25920,,COBRA1; NELFB,9,,Initiation of transcription and translation elongation at the HIV-1 LTR,HIV elongation arrest and recovery; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat; TP53 Regulates Transcription of DNA Repair Genes; Tat-mediated HIV elongation arrest and recovery; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase II Pre-transcription Events; Pausing and recovery of HIV elongation; Pausing and recovery of Tat-mediated HIV elongation; Formation of HIV-1 elongation complex containing HIV-1 Tat; Formation of the Early Elongation Complex,26,High,1
Q9Y2K2,Serine/threonine-protein kinase SIK3 OS=Homo sapiens OX=9606 GN=SIK3 PE=1 SV=4,0,20.995,7,6,11,6,1321,144.8,6.79,3402,3.12,5,2,,,,,,,,,,,,0,High,1
P0DI82,Trafficking protein particle complex subunit 2B OS=Homo sapiens OX=9606 GN=TRAPPC2B PE=1 SV=1,0,20.991,36,4,8,4,140,16.4,6.52,2829,3.33,3,1,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus,DNA binding;metal ion binding;protein binding,"Pf04099, Pf04628",6399; 10597; 284306,ENSG00000256060.2; ENSG00000196459.13,TRAPPC2; TRAPPC2P1; TRAPPC2B; ZNF547,X; 19,,,RAB GEFs exchange GTP for GDP on RABs; COPII (Coat Protein 2) Mediated Vesicle Transport,10,High,1
Q96MV1,TLC domain-containing protein 4 OS=Homo sapiens OX=9606 GN=TLCD4 PE=1 SV=1,0,20.99,12,3,45,3,263,30,9.33,22626,,3,,,membrane,,Pf03798,148534,ENSG00000152078.9,TMEM56,1,,,,0,High,1
Q9HD42,Charged multivesicular body protein 1a OS=Homo sapiens OX=9606 GN=CHMP1A PE=1 SV=1,0,20.973,17,4,35,4,196,21.7,8.06,15493,,4,,cell communication;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,chromosome;cytoplasm;endosome;membrane;nucleus,catalytic activity;metal ion binding;protein binding,Pf03357,5119,ENSG00000131165.14,CHMP1A,16,Endocytosis,,,1,High,1
Q15628,Tumor necrosis factor receptor type 1-associated DEATH domain protein OS=Homo sapiens OX=9606 GN=TRADD PE=1 SV=2,0,20.973,18,4,9,4,312,34.2,6.27,3864,,4,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,protein binding;signal transducer activity,"Pf00531, Pf09034",8717,ENSG00000102871.15,TRADD,16,Apoptosis; TNF signaling pathway; RIG-I-like receptor signaling pathway; NF-kappa B signaling pathway; Sphingolipid signaling pathway; Tuberculosis; Epstein-Barr virus infection; Adipocytokine signaling pathway; Viral carcinogenesis; Hepatitis C,TNF alpha Signaling Pathway; Nanoparticle triggered regulated necrosis; Apoptosis; EBV LMP1 signaling; RIG-I-like Receptor Signaling; p38 MAPK Signaling Pathway,Dimerization of procaspase-8; TNFR1-induced proapoptotic signaling; Regulation of TNFR1 signaling; Regulation by c-FLIP; CASP8 activity is inhibited; TNFR1-induced NFkappaB signaling pathway,32,High,1
Q8N6M3,Fat storage-inducing transmembrane protein 2 OS=Homo sapiens OX=9606 GN=FITM2 PE=1 SV=1,0,20.97,15,4,49,4,262,29.8,8.65,24358,0,3,2,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process,endoplasmic reticulum;membrane;mitochondrion,,Pf10261,128486,ENSG00000197296.5,FITM2,20,,,Lipid particle organization,3,High,1
P78539,Sushi repeat-containing protein SRPX OS=Homo sapiens OX=9606 GN=SRPX PE=1 SV=1,0,20.958,12,5,27,5,464,51.5,8.66,10774,,5,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cell surface;endoplasmic reticulum;membrane;vacuole,,"Pf00084, Pf02494, Pf13778",8406,ENSG00000101955.14,SRPX,X,,,,0,High,1
P51003,Poly(A) polymerase alpha OS=Homo sapiens OX=9606 GN=PAPOLA PE=1 SV=4,0,20.944,10,6,11,6,745,82.8,7.37,4166,,6,,metabolic process;regulation of biological process,cytoplasm;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding,"Pf01909, Pf04926, Pf04928",10914,ENSG00000090060.17,PAPOLA,14,mRNA surveillance pathway,mRNA Processing,Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs; mRNA 3'-end processing; mRNA Splicing - Major Pathway,13,High,1
Q8IZQ5,Selenoprotein H OS=Homo sapiens OX=9606 GN=SELENOH PE=1 SV=2,0,20.944,36,4,13,4,122,13.4,9.74,5243,,4,,,,RNA binding,Pf10262,280636,ENSG00000211450.9,C11orf31; SELENOH,11,,Selenium Micronutrient Network; Selenium Metabolism and Selenoproteins,,2,High,1
Q969S3,Zinc finger protein 622 OS=Homo sapiens OX=9606 GN=ZNF622 PE=1 SV=1,0,20.935,9,3,13,3,477,54.2,6.15,5170,,3,,regulation of biological process;response to stimulus,cytoplasm;cytosol;Golgi;nucleus,metal ion binding;protein binding;RNA binding,"Pf12171, Pf12756, Pf12874",90441,ENSG00000173545.4,ZNF622,5,,,,0,High,1
Q9HB63,Netrin-4 OS=Homo sapiens OX=9606 GN=NTN4 PE=1 SV=2,0,20.918,11,5,21,5,628,70,8.05,7934,,5,,cell communication;cellular component movement;regulation of biological process,extracellular;membrane,protein binding,"Pf00053, Pf00055, Pf01759",59277,ENSG00000074527.11,NTN4,12,Axon guidance,,Netrin-1 signaling; Non-integrin membrane-ECM interactions,6,High,1
Q9BV20,Methylthioribose-1-phosphate isomerase OS=Homo sapiens OX=9606 GN=MRI1 PE=1 SV=1,0,20.913,18,5,32,5,369,39.1,6.3,15836,,5,,metabolic process,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,Pf01008,84245,ENSG00000037757.13,MRI1,19,Cysteine and methionine metabolism; Metabolic pathways,,Methionine salvage pathway,7,High,1
O95218,Zinc finger Ran-binding domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ZRANB2 PE=1 SV=2,0,20.908,11,3,18,3,330,37.4,10.01,7189,,3,,metabolic process;regulation of biological process,nucleus,metal ion binding;protein binding;RNA binding,Pf00641,9406,ENSG00000132485.13,ZRANB2,1,,,,0,High,1
Q13325,Interferon-induced protein with tetratricopeptide repeats 5 OS=Homo sapiens OX=9606 GN=IFIT5 PE=1 SV=1,0,20.901,10,4,26,4,482,55.8,7.4,10369,,4,,defense response;regulation of biological process;response to stimulus,cytoskeleton;membrane,DNA binding;protein binding;RNA binding,"Pf00515, Pf13414, Pf13424",24138,ENSG00000152778.8,IFIT5,10,,,,0,High,1
P47813,"Eukaryotic translation initiation factor 1A, X-chromosomal OS=Homo sapiens OX=9606 GN=EIF1AX PE=1 SV=2",0,20.9,17,2,18,2,144,16.5,5.24,10633,,2,,metabolic process,cytosol,protein binding;RNA binding,Pf01176,1964; 107984923,ENSG00000173674.10,EIF1AX; LOC101060318; LOC107984923,X; 1,RNA transport,Translation Factors,"Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; GTP hydrolysis and joining of the 60S ribosomal subunit; Formation of a pool of free 40S subunits; Ribosomal scanning and start codon recognition",13,High,1
P13598,Intercellular adhesion molecule 2 OS=Homo sapiens OX=9606 GN=ICAM2 PE=1 SV=2,0,20.891,12,3,19,3,275,30.6,7.43,8608,,3,,cell organization and biogenesis;regulation of biological process;response to stimulus,membrane,protein binding,Pf03921,3384,ENSG00000108622.10,ICAM2,17,Cell adhesion molecules (CAMs); Natural killer cell mediated cytotoxicity,,Integrin cell surface interactions; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; CD209 (DC-SIGN) signaling,10,High,1
Q7Z5L9,Interferon regulatory factor 2-binding protein 2 OS=Homo sapiens OX=9606 GN=IRF2BP2 PE=1 SV=2,0,20.879,13,4,11,4,587,61,8.69,4292,,4,,metabolic process;regulation of biological process,cytoplasm;nucleus,metal ion binding,Pf11261,359948,ENSG00000168264.10,IRF2BP2,1,,,,0,High,1
Q5BJD5,Transmembrane protein 41B OS=Homo sapiens OX=9606 GN=TMEM41B PE=1 SV=1,0,20.873,7,1,41,1,291,32.5,9.58,17496,,1,,,membrane,,Pf09335,440026,ENSG00000166471.10,TMEM41B,11,,,,0,High,1
P62745,Rho-related GTP-binding protein RhoB OS=Homo sapiens OX=9606 GN=RHOB PE=1 SV=1,0,20.859,13,2,17,1,196,22.1,5.24,9784,,2,,cell death;cell differentiation;development;regulation of biological process;response to stimulus;transport,cytosol;endosome;membrane;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf08477",388,ENSG00000143878.9,RHOB,2,,Androgen receptor signaling pathway; Neural Crest Differentiation; Spinal Cord Injury; Focal Adhesion,G alpha (12/13) signalling events; RHO GTPases Activate ROCKs; GPVI-mediated activation cascade; Sema4D induced cell migration and growth-cone collapse; Rho GTPase cycle; RHO GTPases Activate Formins; RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases Activate Rhotekin and Rhophilins,24,High,1
P98172,Ephrin-B1 OS=Homo sapiens OX=9606 GN=EFNB1 PE=1 SV=1,0,20.857,22,5,14,5,346,38,8.94,4841,0,5,1,cell communication;cell differentiation;cellular component movement;development;regulation of biological process;response to stimulus,cytoplasm;membrane;nucleus,protein binding,Pf00812,1947,ENSG00000090776.5,EFNB1,X,Axon guidance,,EPH-ephrin mediated repulsion of cells; Ephrin signaling; EPHB-mediated forward signaling,7,High,1
Q9UBU9,Nuclear RNA export factor 1 OS=Homo sapiens OX=9606 GN=NXF1 PE=1 SV=1,0,20.827,11,5,10,5,619,70.1,8.51,4437,,5,,transport,cytoplasm;cytosol;nucleus,protein binding;RNA binding;transporter activity,"Pf02136, Pf03943, Pf09162, Pf12799",10482,ENSG00000162231.13,NXF1,11,RNA transport; Ribosome biogenesis in eukaryotes; Herpes simplex infection; mRNA surveillance pathway; Influenza A,mRNA Processing,Transport of the SLBP independent Mature mRNA; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA,14,High,1
P86397,"Hydroxyacyl-thioester dehydratase type 2, mitochondrial OS=Homo sapiens OX=9606 GN=HTD2 PE=1 SV=1",0,20.806,26,3,37,3,168,18.5,8.92,14146,0,3,1,metabolic process,mitochondrion;nucleus;organelle lumen,catalytic activity;RNA binding,"Pf01575, Pf13452",11102; 109703458,ENSG00000255154.7,RPP14; HTD2,3,,,Fatty acyl-CoA biosynthesis,4,High,1
Q96RT7,Gamma-tubulin complex component 6 OS=Homo sapiens OX=9606 GN=TUBGCP6 PE=1 SV=3,0,20.804,4,5,12,5,1819,200.4,6.32,4247,,5,,cell differentiation;cell organization and biogenesis,cytoplasm;cytoskeleton;cytosol;membrane,protein binding;structural molecule activity,"Pf04130, Pf07111, Pf13868, Pf15346",85378,ENSG00000128159.11,TUBGCP6,22,,,Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes,9,High,1
P28370,Probable global transcription activator SNF2L1 OS=Homo sapiens OX=9606 GN=SMARCA1 PE=1 SV=2,0,20.802,4,5,25,2,1054,122.5,8.09,12952,,5,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process,nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding,"Pf00176, Pf00270, Pf00271, Pf04851, Pf09110, Pf09111, Pf11496, Pf13892",6594,ENSG00000102038.15,SMARCA1,X,,,,0,High,1
Q9NZZ3,Charged multivesicular body protein 5 OS=Homo sapiens OX=9606 GN=CHMP5 PE=1 SV=1,0,20.777,13,2,16,2,219,24.6,4.83,9701,0,2,1,cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytosol;endosome;membrane;nucleus,protein binding,Pf03357,51510,ENSG00000086065.13,CHMP5,9,Endocytosis,,Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT),10,High,1
O43251,RNA binding protein fox-1 homolog 2 OS=Homo sapiens OX=9606 GN=RBFOX2 PE=1 SV=3,0,20.776,13,4,21,1,390,41.3,7.27,8598,,4,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,protein binding;RNA binding,"Pf00076, Pf12414, Pf13893, Pf14259",23543,,RBFOX2,22,,,FGFR2 alternative splicing,5,High,1
P45877,Peptidyl-prolyl cis-trans isomerase C OS=Homo sapiens OX=9606 GN=PPIC PE=1 SV=1,0,20.758,16,4,87,3,212,22.7,8.4,47686,,4,,metabolic process,cytoplasm,catalytic activity;protein binding,Pf00160,5480,ENSG00000168938.5,PPIC,5,,,,0,High,1
Q9NXJ5,Pyroglutamyl-peptidase 1 OS=Homo sapiens OX=9606 GN=PGPEP1 PE=1 SV=1,0,20.746,28,3,22,3,209,23.1,5.9,10003,,3,,metabolic process,cytoplasm;cytosol,catalytic activity,Pf01470,54858,ENSG00000130517.13,PGPEP1,19,,,,0,High,1
P00414,Cytochrome c oxidase subunit 3 OS=Homo sapiens OX=9606 GN=MT-CO3 PE=1 SV=2,0,20.728,9,2,49,2,261,29.9,7.31,17116,,2,,cell organization and biogenesis;metabolic process;transport,membrane;mitochondrion,catalytic activity;protein binding;transporter activity,Pf00510,4514,ENSG00000198938.2,COX3,MT,Parkinson's disease; Cardiac muscle contraction; Oxidative phosphorylation; Huntington's disease; Non-alcoholic fatty liver disease (NAFLD); Metabolic pathways; Alzheimer's disease,Electron Transport Chain,TP53 Regulates Metabolic Genes; Respiratory electron transport,17,High,1
Q9P0P0,E3 ubiquitin-protein ligase RNF181 OS=Homo sapiens OX=9606 GN=RNF181 PE=1 SV=1,0,20.706,35,4,22,4,153,17.9,5.06,8567,,4,,metabolic process,cytoplasm,catalytic activity;metal ion binding;protein binding,"Pf00097, Pf12678, Pf12861, Pf13639, Pf13923",51255,ENSG00000168894.9,RNF181,2,,,E3 ubiquitin ligases ubiquitinate target proteins,4,High,1
Q13136,Liprin-alpha-1 OS=Homo sapiens OX=9606 GN=PPFIA1 PE=1 SV=1,0,20.694,6,5,6,5,1202,135.7,6.29,2295,,5,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;Golgi;nucleus,catalytic activity;motor activity;protein binding;signal transducer activity,"Pf00536, Pf01576, Pf02463, Pf04012, Pf04111, Pf04156, Pf05557, Pf05622, Pf06008, Pf06160, Pf06391, Pf07647, Pf09726, Pf09728, Pf09731, Pf10174, Pf12072, Pf12128, Pf12718, Pf12795, Pf13166, Pf13851, Pf14915, Pf15066, Pf15070, Pf15619",8500,ENSG00000131626.16,PPFIA1,11,,,Norepinephrine Neurotransmitter Release Cycle; Receptor-type tyrosine-protein phosphatases; Glutamate Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle,10,High,1
Q9H0M0,NEDD4-like E3 ubiquitin-protein ligase WWP1 OS=Homo sapiens OX=9606 GN=WWP1 PE=1 SV=1,0,20.693,5,4,16,2,922,105.1,5.9,6095,0,4,1,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus,catalytic activity;protein binding,"Pf00168, Pf00397, Pf00632",11059,ENSG00000123124.13,WWP1,8,Ubiquitin mediated proteolysis; Endocytosis,TGF-beta Signaling Pathway,Regulation of RUNX2 expression and activity; Antigen processing: Ubiquitination & Proteasome degradation; Stimuli-sensing channels; Downregulation of ERBB4 signaling,19,High,1
Q9UBI6,Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 OS=Homo sapiens OX=9606 GN=GNG12 PE=1 SV=3,0,20.682,25,2,19,2,72,8,8.97,9796,,2,,regulation of biological process;response to stimulus,membrane,protein binding;signal transducer activity,Pf00631,55970,ENSG00000172380.5,GNG12,1,GABAergic synapse; Circadian entrainment; Dopaminergic synapse; Ras signaling pathway; Regulation of actin cytoskeleton; Glutamatergic synapse; PI3K-Akt signaling pathway; Morphine addiction; Chemokine signaling pathway; MAPK signaling pathway; Alcoholism; Serotonergic synapse; Retrograde endocannabinoid signaling; Pathways in cancer; Cholinergic synapse,Myometrial Relaxation and Contraction Pathways; G Protein Signaling Pathways; Chemokine signaling pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Regulation of Actin Cytoskeleton; Calcium Regulation in the Cardiac Cell,"G alpha (z) signalling events; Activation of G protein gated Potassium channels; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; ADP signalling through P2Y purinoceptor 1; G beta:gamma signalling through PI3Kgamma; Vasopressin regulates renal water homeostasis via Aquaporins; G-protein activation; Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits; G alpha (12/13) signalling events; G alpha (s) signalling events; Ca2+ pathway; ADP signalling through P2Y purinoceptor 12; Adrenaline,noradrenaline inhibits insulin secretion; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Presynaptic function of Kainate receptors; G beta:gamma signalling through PLC beta; Glucagon signaling in metabolic regulation; Thrombin signalling through proteinase activated receptors (PARs); Prostacyclin signalling through prostacyclin receptor; Gastrin-CREB signalling pathway via PKC and MAPK",76,High,1
Q9UBP4,Dickkopf-related protein 3 OS=Homo sapiens OX=9606 GN=DKK3 PE=1 SV=2,0,20.671,13,4,22,4,350,38.4,4.65,8943,0,4,1,development;regulation of biological process;response to stimulus,extracellular,,"Pf04706, Pf06607",27122,ENSG00000050165.17,DKK3,11,,Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds,,1,High,1
Q6NXT6,Transmembrane anterior posterior transformation protein 1 homolog OS=Homo sapiens OX=9606 GN=TAPT1 PE=1 SV=1,0,20.664,9,4,21,4,567,64.2,8.28,7971,,4,,cell differentiation;cell organization and biogenesis;development;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;membrane,receptor activity;signal transducer activity,Pf05346,202018,ENSG00000169762.16,TAPT1,4,,,,0,High,1
Q9BQK8,Phosphatidate phosphatase LPIN3 OS=Homo sapiens OX=9606 GN=LPIN3 PE=1 SV=3,0,20.66,6,5,22,5,851,93.6,5.52,8067,,5,,metabolic process;regulation of biological process,membrane;nucleus,catalytic activity,"Pf04571, Pf08235, Pf15017",64900,ENSG00000132793.11,LPIN3,20,Glycerolipid metabolism; Glycerophospholipid metabolism; Metabolic pathways,Adipogenesis,Synthesis of PC; Depolymerisation of the Nuclear Lamina; Triglyceride biosynthesis; Synthesis of PE,18,High,1
Q9NVG8,TBC1 domain family member 13 OS=Homo sapiens OX=9606 GN=TBC1D13 PE=1 SV=3,0,20.654,16,5,13,5,400,46.5,5.24,4579,,5,,regulation of biological process;transport,cytoplasm;cytosol;membrane,enzyme regulator activity;protein binding,Pf00566,54662,ENSG00000107021.15,TBC1D13,9,,,TBC/RABGAPs,4,High,1
Q8IZ52,Chondroitin sulfate synthase 2 OS=Homo sapiens OX=9606 GN=CHPF PE=1 SV=2,0,20.649,10,5,10,5,775,85.4,6.93,5410,,5,,metabolic process,cytoplasm;cytosol;Golgi;membrane;mitochondrion;organelle lumen,catalytic activity;metal ion binding;protein binding,"Pf02434, Pf05679",79586,ENSG00000123989.13,CHPF,2,Metabolic pathways; Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate,,Chondroitin sulfate biosynthesis,7,High,1
O14640,Segment polarity protein dishevelled homolog DVL-1 OS=Homo sapiens OX=9606 GN=DVL1 PE=1 SV=2,0,20.624,10,5,16,5,695,75.1,7.81,5438,,5,,cell growth;cell organization and biogenesis;cellular component movement;development;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane,protein binding,"Pf00595, Pf00610, Pf00778, Pf12316",1855,ENSG00000107404.19,DVL1,1,Basal cell carcinoma; Melanogenesis; Signaling pathways regulating pluripotency of stem cells; Hippo signaling pathway; Wnt signaling pathway; Breast cancer; mTOR signaling pathway; Pathways in cancer; Notch signaling pathway; HTLV-I infection,MicroRNAs in cardiomyocyte hypertrophy; Regulation of Microtubule Cytoskeleton; Neural Crest Differentiation; Adipogenesis; Notch Signaling Pathway; Wnt Signaling Pathway Netpath; Association Between Physico-Chemical Features and Toxicity Associated Pathways; ESC Pluripotency Pathways; Wnt Signaling in Kidney Disease; Wnt Signaling Pathway and Pluripotency; Wnt Signaling Pathway; DNA Damage Response (only ATM dependent),Disassembly of the destruction complex and recruitment of AXIN to the membrane; WNT mediated activation of DVL; RHO GTPases Activate Formins; PCP/CE pathway; Degradation of DVL; Negative regulation of TCF-dependent signaling by DVL-interacting proteins,34,High,1
P49207,60S ribosomal protein L34 OS=Homo sapiens OX=9606 GN=RPL34 PE=1 SV=3,0,20.59,14,3,87,3,117,13.3,11.47,41120,,3,,cell organization and biogenesis;metabolic process;transport,cytosol;mitochondrion;ribosome,protein binding;RNA binding;structural molecule activity,Pf01199,6164,ENSG00000109475.16,RPL34,4,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
Q9ULC3,Ras-related protein Rab-23 OS=Homo sapiens OX=9606 GN=RAB23 PE=1 SV=1,0,20.589,24,5,20,5,237,26.6,6.6,7992,,5,,cell organization and biogenesis;defense response;development;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane;vacuole,catalytic activity;nucleotide binding;protein binding,"Pf00009, Pf00025, Pf00071, Pf04670, Pf08477",51715,ENSG00000112210.11,RAB23,6,,,RAB geranylgeranylation,3,High,1
P51532,Transcription activator BRG1 OS=Homo sapiens OX=9606 GN=SMARCA4 PE=1 SV=2,0,20.578,3,4,21,1,1647,184.5,7.88,8851,,4,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,membrane;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding,"Pf00176, Pf00270, Pf00271, Pf00439, Pf07529, Pf07533, Pf08880, Pf11496, Pf14619",6597,ENSG00000127616.17,SMARCA4,19,,Preimplantation Embryo; Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex,RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines; Formation of the beta-catenin:TCF transactivating complex; Interleukin-7 signaling,18,High,1
Q8TD55,Pleckstrin homology domain-containing family O member 2 OS=Homo sapiens OX=9606 GN=PLEKHO2 PE=1 SV=1,0,20.565,16,5,16,5,490,53.3,5.43,6451,,5,,transport,extracellular,,"Pf00169, Pf15413",80301,ENSG00000241839.9,PLEKHO2,15,Cytokine-cytokine receptor interaction,,Neutrophil degranulation,4,High,1
Q9Y619,Mitochondrial ornithine transporter 1 OS=Homo sapiens OX=9606 GN=SLC25A15 PE=1 SV=1,0,20.561,20,4,16,4,301,32.7,9.13,7374,,4,,metabolic process;transport,membrane;mitochondrion,transporter activity,Pf00153,10166,ENSG00000102743.14,SLC25A15,13,,,Urea cycle,4,High,1
Q9Y3B4,Splicing factor 3B subunit 6 OS=Homo sapiens OX=9606 GN=SF3B6 PE=1 SV=1,0,20.55,21,2,15,2,125,14.6,9.38,7383,,2,,metabolic process,nucleus;spliceosomal complex,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",51639,ENSG00000115128.6,SF3B14; SF3B6,2,Spliceosome,,mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway,6,High,1
P04839,Cytochrome b-245 heavy chain OS=Homo sapiens OX=9606 GN=CYBB PE=1 SV=2,0,20.548,8,4,23,3,570,65.3,8.63,8679,,4,,cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;Golgi;membrane;mitochondrion,catalytic activity;metal ion binding;nucleotide binding;protein binding;transporter activity,"Pf00175, Pf00970, Pf01794, Pf08022, Pf08030",1536,ENSG00000165168.7,CYBB,X,Leukocyte transendothelial migration; HIF-1 signaling pathway; Phagosome; Osteoclast differentiation; AGE-RAGE signaling pathway in diabetic complications; NOD-like receptor signaling pathway,Microglia Pathogen Phagocytosis Pathway; Type II interferon signaling (IFNG),"ROS, RNS production in phagocytes; Neutrophil degranulation; Cross-presentation of particulate exogenous antigens (phagosomes); VEGFA-VEGFR2 Pathway; Detoxification of Reactive Oxygen Species; RHO GTPases Activate NADPH Oxidases",26,High,1
Q02539,Histone H1.1 OS=Homo sapiens OX=9606 GN=H1-1 PE=1 SV=3,0,20.543,14,4,117,1,215,21.8,10.99,71321,0,4,1,cell organization and biogenesis;regulation of biological process,cell surface;chromosome;nucleus,DNA binding;protein binding,Pf00538,3024,ENSG00000124610.4,HIST1H1A,6,,,Formation of Senescence-Associated Heterochromatin Foci (SAHF); Activation of DNA fragmentation factor,10,High,1
P49006,MARCKS-related protein OS=Homo sapiens OX=9606 GN=MARCKSL1 PE=1 SV=2,0,20.528,29,3,35,3,195,19.5,4.67,15464,,3,,regulation of biological process,cytoplasm;membrane,protein binding,,65108,ENSG00000175130.6,MARCKSL1,1,Leishmaniasis; Fc gamma R-mediated phagocytosis,,,2,High,1
Q8TEW0,Partitioning defective 3 homolog OS=Homo sapiens OX=9606 GN=PARD3 PE=1 SV=2,0,20.519,4,5,15,5,1356,151.3,7.68,3934,0,5,1,cell differentiation;cell division;cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane,protein binding,"Pf00595, Pf12053, Pf13180",56288,ENSG00000148498.15,PARD3,10,Hippo signaling pathway; Adherens junction; Endocytosis; Rap1 signaling pathway; Tight junction; Chemokine signaling pathway; Neuroactive ligand-receptor interaction,Chemokine signaling pathway,Tight junction interactions; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition),16,High,1
P49758,Regulator of G-protein signaling 6 OS=Homo sapiens OX=9606 GN=RGS6 PE=1 SV=5,0,20.509,10,4,30,4,472,54.4,7.42,9160,2.04,4,1,regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,enzyme regulator activity;protein binding;signal transducer activity,"Pf00610, Pf00615, Pf00631",9628,ENSG00000182732.16,RGS6,14,,Myometrial Relaxation and Contraction Pathways; Calcium Regulation in the Cardiac Cell,Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G alpha (i) signalling events,10,High,1
Q8NBJ7,Inactive C-alpha-formylglycine-generating enzyme 2 OS=Homo sapiens OX=9606 GN=SUMF2 PE=1 SV=2,0,20.505,17,5,28,5,301,33.8,8,9924,,5,,metabolic process,endoplasmic reticulum;organelle lumen,metal ion binding,Pf03781,25870,,SUMF2,7,,,The activation of arylsulfatases; Glycosphingolipid metabolism,8,High,1
Q8WZA1,"Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 OS=Homo sapiens OX=9606 GN=POMGNT1 PE=1 SV=2",0,20.499,10,4,18,4,660,75.2,6.83,6944,4.91,3,1,metabolic process,Golgi;membrane,catalytic activity;protein binding,Pf03071,55624,ENSG00000085998.13,POMGNT1,1,Other types of O-glycan biosynthesis,,"Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3; O-linked glycosylation",8,High,1
P0DP02,Immunoglobulin heavy variable 3-30-3 OS=Homo sapiens OX=9606 GN=IGHV3-30-3 PE=3 SV=1,0,20.496,26,3,50,1,117,13,8.94,26329,,3,,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity,,28439; 57290,ENSG00000282642.1,IGHV3-30; IGHV3-30-3,14; CHR_HSCHR14_3_CTG1,,,,0,High,1
Q8IVH8,Mitogen-activated protein kinase kinase kinase kinase 3 OS=Homo sapiens OX=9606 GN=MAP4K3 PE=1 SV=1,0,20.474,6,3,18,3,894,101.3,7.56,6005,,3,,metabolic process;regulation of biological process;response to stimulus,cytoplasm,catalytic activity;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf00780, Pf07714",8491,ENSG00000011566.14,MAP4K3,2,MAPK signaling pathway,MAPK Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; Insulin Signaling,,4,High,1
P09467,"Fructose-1,6-bisphosphatase 1 OS=Homo sapiens OX=9606 GN=FBP1 PE=1 SV=5",0,20.435,16,4,10,4,338,36.8,6.99,3898,,4,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00316, Pf00459",2203,ENSG00000165140.9,FBP1,9,Pentose phosphate pathway; Insulin signaling pathway; Metabolic pathways; Glucagon signaling pathway; AMPK signaling pathway; Fructose and mannose metabolism; Carbon metabolism; Glycolysis / Gluconeogenesis,Angiopoietin Like Protein 8 Regulatory Pathway; Glycolysis and Gluconeogenesis,Gluconeogenesis,14,High,1
Q99735,Microsomal glutathione S-transferase 2 OS=Homo sapiens OX=9606 GN=MGST2 PE=1 SV=1,0,20.428,18,2,42,2,147,16.6,9.55,16418,,2,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;endoplasmic reticulum;membrane,antioxidant activity;catalytic activity;enzyme regulator activity;protein binding,Pf01124,4258,ENSG00000085871.8,MGST2,4,Metabolism of xenobiotics by cytochrome P450; Chemical carcinogenesis; Platinum drug resistance; Drug metabolism - cytochrome P450; Glutathione metabolism,NRF2 pathway; Metapathway biotransformation,Glutathione conjugation; Aflatoxin activation and detoxification,12,High,1
Q9BRP8,Partner of Y14 and mago OS=Homo sapiens OX=9606 GN=PYM1 PE=1 SV=1,0,20.426,21,3,11,3,204,22.6,9.45,6929,,3,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,protein binding;RNA binding,Pf09282,84305,ENSG00000170473.16,WIBG; PYM1,12,mRNA surveillance pathway; RNA transport,,,2,High,1
P04920,Anion exchange protein 2 OS=Homo sapiens OX=9606 GN=SLC4A2 PE=1 SV=4,0,20.411,6,5,24,3,1241,136.9,6.29,9628,,5,,cellular homeostasis;transport,membrane,protein binding;transporter activity,"Pf00955, Pf07565",6522,ENSG00000164889.13,SLC4A2,7,Gastric acid secretion; Bile secretion; Salivary secretion; Pancreatic secretion,,Bicarbonate transporters,8,High,1
Q86SZ2,Trafficking protein particle complex subunit 6B OS=Homo sapiens OX=9606 GN=TRAPPC6B PE=1 SV=1,0,20.403,26,5,39,5,158,18,8.68,13813,0,5,1,cell organization and biogenesis;transport,cytosol;endoplasmic reticulum;Golgi;membrane,protein binding,Pf04051,122553,ENSG00000182400.14,TRAPPC6B,14,,,RAB GEFs exchange GTP for GDP on RABs; COPII (Coat Protein 2) Mediated Vesicle Transport,10,High,1
Q5T0F9,Coiled-coil and C2 domain-containing protein 1B OS=Homo sapiens OX=9606 GN=CC2D1B PE=1 SV=1,0,20.388,8,5,8,5,858,94.2,5.26,3081,,5,,metabolic process;regulation of biological process,nucleus,DNA binding;protein binding,Pf00168,200014,ENSG00000154222.14,CC2D1B,1,,,,0,High,1
P41208,Centrin-2 OS=Homo sapiens OX=9606 GN=CETN2 PE=1 SV=1,0,20.355,20,3,23,3,172,19.7,5,10212,,3,,cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;nucleus,metal ion binding;protein binding,"Pf00036, Pf13202, Pf13405, Pf13499, Pf13833",1069,ENSG00000147400.8,CETN2,X,Nucleotide excision repair,,Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Loss of Nlp from mitotic centrosomes; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; SUMOylation of DNA damage response and repair proteins,27,High,1
P11172,Uridine 5'-monophosphate synthase OS=Homo sapiens OX=9606 GN=UMPS PE=1 SV=1,0,20.302,11,4,15,4,480,52.2,7.24,4356,,4,,metabolic process;response to stimulus;transport,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,"Pf00156, Pf00215",7372,ENSG00000114491.13,UMPS,3,Pyrimidine metabolism; Drug metabolism - other enzymes; Metabolic pathways,Fluoropyrimidine Activity,Pyrimidine biosynthesis,8,High,1
P05154,Plasma serine protease inhibitor OS=Homo sapiens OX=9606 GN=SERPINA5 PE=1 SV=3,0,20.278,11,4,13,4,406,45.6,9.26,6125,,4,,cell organization and biogenesis;coagulation;regulation of biological process;transport,extracellular;membrane,enzyme regulator activity;protein binding,Pf00079,5104,ENSG00000188488.13,SERPINA5,14,Complement and coagulation cascades,Complement and Coagulation Cascades,Common Pathway of Fibrin Clot Formation; Intrinsic Pathway of Fibrin Clot Formation,6,High,1
Q6UWP8,Suprabasin OS=Homo sapiens OX=9606 GN=SBSN PE=1 SV=2,0,20.27,23,5,24,5,590,60.5,7.01,5972,2.67,5,1,,extracellular,,,374897,ENSG00000189001.10,SBSN,19,,,,0,High,1
Q86U38,Nucleolar protein 9 OS=Homo sapiens OX=9606 GN=NOP9 PE=1 SV=1,0,20.24,13,5,11,5,636,69.4,7.28,4523,,5,,,,RNA binding,,161424,ENSG00000196943.12,NOP9,14,,,,0,High,1
O00443,Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha OS=Homo sapiens OX=9606 GN=PIK3C2A PE=1 SV=2,0,20.233,4,6,14,6,1686,190.6,8.02,5217,,6,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;Golgi;membrane;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00168, Pf00454, Pf00613, Pf00787, Pf00792, Pf00794",5286,ENSG00000011405.13,PIK3C2A,11,Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system,Signaling Pathways in Glioblastoma; Angiopoietin Like Protein 8 Regulatory Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Microglia Pathogen Phagocytosis Pathway; Insulin Signaling; Regulation of Actin Cytoskeleton; DNA Damage Response (only ATM dependent),Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; Golgi Associated Vesicle Biogenesis,24,High,1
Q6UN15,Pre-mRNA 3'-end-processing factor FIP1 OS=Homo sapiens OX=9606 GN=FIP1L1 PE=1 SV=1,0,20.226,10,3,10,3,594,66.5,5.59,3355,,3,,metabolic process;transport,nucleus,protein binding;RNA binding,Pf05182,81608,ENSG00000145216.15,FIP1L1,4,mRNA surveillance pathway,,mRNA 3'-end processing; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA Splicing - Major Pathway; Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs,15,High,1
Q8TDN6,Ribosome biogenesis protein BRX1 homolog OS=Homo sapiens OX=9606 GN=BRIX1 PE=1 SV=2,0,20.218,19,4,14,4,353,41.4,9.92,5345,0,4,1,cell organization and biogenesis,nucleus,RNA binding,Pf04427,55299,ENSG00000113460.12,BRIX1,5,,Gastric cancer network 2,,1,High,1
Q9P2K5,Myelin expression factor 2 OS=Homo sapiens OX=9606 GN=MYEF2 PE=1 SV=3,0,20.215,12,5,9,5,600,64.1,8.75,3713,,5,,cell differentiation;metabolic process;regulation of biological process,nucleus,DNA binding;protein binding;RNA binding,"Pf00076, Pf08777, Pf11608, Pf13893, Pf14259",50804,,MYEF2,15,,Physiological and Pathological Hypertrophy  of the Heart; MicroRNAs in cardiomyocyte hypertrophy; TFs Regulate miRNAs related to cardiac hypertrophy; Mitochondrial Gene Expression,,4,High,1
Q9BX97,Plasmalemma vesicle-associated protein OS=Homo sapiens OX=9606 GN=PLVAP PE=1 SV=1,0,20.191,12,4,20,4,442,50.6,8.79,8215,,4,,metabolic process;regulation of biological process;response to stimulus,cell surface;cytoplasm;membrane,protein binding,Pf06637,83483,ENSG00000130300.8,PLVAP,19,,,,0,High,1
Q9H2V7,Protein spinster homolog 1 OS=Homo sapiens OX=9606 GN=SPNS1 PE=1 SV=1,0,20.17,14,4,14,4,528,56.6,6.64,5774,,4,,regulation of biological process;response to stimulus;transport,membrane;mitochondrion,protein binding;transporter activity,"Pf00083, Pf07690",83985,ENSG00000169682.17,SPNS1,16,,,,0,High,1
Q8N9N2,Activating signal cointegrator 1 complex subunit 1 OS=Homo sapiens OX=9606 GN=ASCC1 PE=1 SV=1,0,20.157,9,4,26,3,400,45.5,5.54,11122,,4,,metabolic process;regulation of biological process,nucleus,protein binding;RNA binding,"Pf00013, Pf10469, Pf13014",51008,ENSG00000138303.17,ASCC1,10,,,ALKBH3 mediated reversal of alkylation damage,4,High,1
P13284,Gamma-interferon-inducible lysosomal thiol reductase OS=Homo sapiens OX=9606 GN=IFI30 PE=1 SV=3,0,20.141,4,1,92,1,250,27.9,4.88,33868,,1,,metabolic process;regulation of biological process;response to stimulus,cytosol;extracellular;organelle lumen;vacuole,catalytic activity;protein binding,Pf03227,10437,ENSG00000216490.3,IFI30,19,Antigen processing and presentation,,MHC class II antigen presentation; Interferon gamma signaling,7,High,1
O75907,Diacylglycerol O-acyltransferase 1 OS=Homo sapiens OX=9606 GN=DGAT1 PE=1 SV=2,0,20.125,11,3,14,3,488,55.2,9.32,5544,,3,,cell organization and biogenesis;metabolic process;transport,endoplasmic reticulum;membrane,catalytic activity;protein binding,Pf03062,8694,ENSG00000185000.11,DGAT1,8,Fat digestion and absorption; Retinol metabolism; Metabolic pathways; Glycerolipid metabolism,Triacylglyceride Synthesis; Statin Pathway; Vitamin A and Carotenoid Metabolism,Triglyceride biosynthesis; Neutrophil degranulation; Acyl chain remodeling of DAG and TAG,17,High,1
Q9GZZ1,N-alpha-acetyltransferase 50 OS=Homo sapiens OX=9606 GN=NAA50 PE=1 SV=1,0,20.066,25,4,28,4,169,19.4,8.81,11642,,4,,cell organization and biogenesis;metabolic process,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,"Pf00583, Pf13420, Pf13508, Pf13527, Pf13673",80218,ENSG00000121579.12,NAA50,3,,Metapathway biotransformation,,1,High,1
Q86V87,Protein FAM160B2 OS=Homo sapiens OX=9606 GN=FAM160B2 PE=2 SV=2,0,20.043,9,4,20,3,743,82.3,5.47,9559,,4,,,,,Pf10257,64760,ENSG00000158863.21,FAM160B2,8,,,,0,High,1
Q9NZD8,Maspardin OS=Homo sapiens OX=9606 GN=SPG21 PE=1 SV=1,0,20.021,15,4,12,4,308,34.9,6.28,5133,,4,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endosome;Golgi;membrane,catalytic activity;protein binding,"Pf00561, Pf00975, Pf12695, Pf12697",51324,ENSG00000090487.10,SPG21,15,Endocytosis,,,1,High,1
Q9BU89,Deoxyhypusine hydroxylase OS=Homo sapiens OX=9606 GN=DOHH PE=1 SV=1,0,20.01,19,4,15,4,302,32.9,4.83,6084,0,4,1,metabolic process,cytosol,catalytic activity;metal ion binding;protein binding,Pf13646,83475,ENSG00000129932.7,DOHH,19,,,Hypusine synthesis from eIF5A-lysine,4,High,1
Q03113,Guanine nucleotide-binding protein subunit alpha-12 OS=Homo sapiens OX=9606 GN=GNA12 PE=1 SV=4,0,20.008,16,6,16,4,381,44.3,9.83,5387,,6,,cell differentiation;coagulation;regulation of biological process;response to stimulus,cytoplasm;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,"Pf00025, Pf00503",2768,ENSG00000146535.13,GNA12,7,Pathways in cancer; Vascular smooth muscle contraction; Sphingolipid signaling pathway; cGMP-PKG signaling pathway; Long-term depression; MAPK signaling pathway; Phospholipase D signaling pathway; Regulation of actin cytoskeleton,Human Thyroid Stimulating Hormone (TSH) signaling pathway; G Protein Signaling Pathways; MAPK Signaling Pathway; Regulation of Actin Cytoskeleton,Thrombin signalling through proteinase activated receptors (PARs); G alpha (12/13) signalling events,19,High,1
Q6P1J9,Parafibromin OS=Homo sapiens OX=9606 GN=CDC73 PE=1 SV=1,0,20.008,9,5,20,5,531,60.5,9.61,9830,,5,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytosol;nucleus,protein binding,Pf05179,79577,ENSG00000134371.10,CDC73,1,,Endoderm Differentiation,Hedgehog 'on' state; E3 ubiquitin ligases ubiquitinate target proteins; Formation of RNA Pol II elongation complex ; Formation of the beta-catenin:TCF transactivating complex; RNA Polymerase II Pre-transcription Events,16,High,1
Q92636,Protein FAN OS=Homo sapiens OX=9606 GN=NSMAF PE=1 SV=2,0,19.959,6,4,29,4,917,104.3,6.23,10643,,4,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,enzyme regulator activity;protein binding;signal transducer activity,"Pf00400, Pf02138, Pf02893, Pf14844",8439,ENSG00000035681.7,NSMAF,8,Sphingolipid signaling pathway,TNF alpha Signaling Pathway,TNFR1-mediated ceramide production,6,High,1
Q96T37,RNA-binding protein 15 OS=Homo sapiens OX=9606 GN=RBM15 PE=1 SV=2,0,19.956,8,5,16,5,977,107.1,10.08,6956,0,5,1,metabolic process;regulation of biological process,membrane;nucleus,protein binding;RNA binding,"Pf00076, Pf07744, Pf13893, Pf14259",64783,ENSG00000162775.14,RBM15,1,,,,0,High,1
P51689,Arylsulfatase D OS=Homo sapiens OX=9606 GN=ARSD PE=1 SV=2,0,19.932,8,3,8,3,593,64.8,7.23,3272,,3,,metabolic process,membrane;organelle lumen;vacuole,catalytic activity;metal ion binding,"Pf00884, Pf14707",414,ENSG00000006756.15,ARSD,X,,Estrogen metabolism,The activation of arylsulfatases; Glycosphingolipid metabolism,9,High,1
Q9Y259,Choline/ethanolamine kinase OS=Homo sapiens OX=9606 GN=CHKB PE=1 SV=3,0,19.931,10,3,16,3,395,45.2,5.49,6979,0,3,1,metabolic process,cytosol,catalytic activity;nucleotide binding,"Pf01633, Pf01636",1120,ENSG00000100288.19,CHKB,22,Choline metabolism in cancer; Metabolic pathways; Glycerophospholipid metabolism,Fatty Acid Beta Oxidation; Kennedy pathway; One carbon metabolism and related pathways,Synthesis of PC; Synthesis of PE,12,High,1
Q6NXE6,Armadillo repeat-containing protein 6 OS=Homo sapiens OX=9606 GN=ARMC6 PE=1 SV=2,0,19.929,12,4,15,4,501,54.1,6.24,5525,,4,,cell differentiation,cytosol,protein binding,Pf00514,93436,ENSG00000105676.13,ARMC6,19,,,,0,High,1
Q06828,Fibromodulin OS=Homo sapiens OX=9606 GN=FMOD PE=1 SV=2,0,19.915,13,4,20,4,376,43.2,6.04,6883,,4,,cell organization and biogenesis;metabolic process,extracellular;organelle lumen,protein binding,"Pf01462, Pf12799, Pf13855, Pf14580",2331,ENSG00000122176.10,FMOD,1,,,ECM proteoglycans; Keratan sulfate biosynthesis; Defective CHST6 causes MCDC1; Defective ST3GAL3 causes MCT12 and EIEE15; Keratan sulfate degradation; Defective B4GALT1 causes B4GALT1-CDG (CDG-2d),14,High,1
Q9UJP4,Kelch-like protein 21 OS=Homo sapiens OX=9606 GN=KLHL21 PE=1 SV=4,0,19.904,8,4,8,4,597,66.6,5.36,2517,4.8,3,1,cell division;metabolic process;regulation of biological process,cytoplasm;cytoskeleton;cytosol,catalytic activity;protein binding,"Pf00651, Pf01344, Pf07646, Pf07707, Pf13415, Pf13418, Pf13964",9903,ENSG00000162413.16,KLHL21,1,,,Antigen processing: Ubiquitination & Proteasome degradation; Neddylation,7,High,1
Q9Y2E5,Epididymis-specific alpha-mannosidase OS=Homo sapiens OX=9606 GN=MAN2B2 PE=1 SV=4,0,19.9,10,7,12,7,1009,113.9,7.24,3092,2.88,6,1,metabolic process,extracellular;organelle lumen,catalytic activity;metal ion binding,"Pf01074, Pf07748, Pf09261",23324,ENSG00000013288.8,MAN2B2,4,Other glycan degradation,,Lysosomal oligosaccharide catabolism,4,High,1
P14209,CD99 antigen OS=Homo sapiens OX=9606 GN=CD99 PE=1 SV=1,0,19.897,17,2,11,2,185,18.8,4.75,5417,,2,,regulation of biological process,cytoplasm;membrane,protein binding,Pf12301,4267,ENSG00000002586.18,CD99,X|Y; X,Cell adhesion molecules (CAMs); Leukocyte transendothelial migration,,Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall,7,High,1
Q8N139,ATP-binding cassette sub-family A member 6 OS=Homo sapiens OX=9606 GN=ABCA6 PE=1 SV=2,0,19.896,5,5,19,4,1617,184.2,7.36,6934,1.93,5,1,transport,membrane,catalytic activity;nucleotide binding;transporter activity,"Pf00005, Pf03193, Pf12698, Pf13304",23460,ENSG00000154262.12,ABCA6,17,ABC transporters,,ABC transporters in lipid homeostasis,4,High,1
P13196,"5-aminolevulinate synthase, nonspecific, mitochondrial OS=Homo sapiens OX=9606 GN=ALAS1 PE=1 SV=2",0,19.863,12,4,14,4,640,70.5,8.46,4264,,4,,cell organization and biogenesis;metabolic process;regulation of biological process,cytosol;mitochondrion;organelle lumen,catalytic activity;protein binding,"Pf00155, Pf00266, Pf01053, Pf01212, Pf09029",211,ENSG00000023330.14,ALAS1,3,"Metabolic pathways; Porphyrin and chlorophyll metabolism; Glycine, serine and threonine metabolism",Constitutive Androstane Receptor Pathway; Heme Biosynthesis,Heme biosynthesis; Transcriptional activation of mitochondrial biogenesis; PPARA activates gene expression,14,High,1
Q13315,Serine-protein kinase ATM OS=Homo sapiens OX=9606 GN=ATM PE=1 SV=4,0,19.855,3,7,18,7,3056,350.5,6.81,5308,,7,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding;transporter activity,"Pf00454, Pf02259, Pf02260, Pf11640",472,ENSG00000149311.18,ATM,11,Cell cycle; Apoptosis; MicroRNAs in cancer; Platinum drug resistance; Transcriptional misregulation in cancer; NF-kappa B signaling pathway; FoxO signaling pathway; p53 signaling pathway; HTLV-I infection; Homologous recombination,miRNA Regulation of DNA Damage Response; miRNAs involved in DNA damage response; TP53 Network; Cell Cycle; Homologous recombination; Signaling Pathways in Glioblastoma; ATM Signaling Pathway; DDX1 as a regulatory component of the Drosha microprocessor; Ovarian Infertility Genes; Pathways Affected in Adenoid Cystic Carcinoma; Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex; ATM Signaling Network in Development and Disease; DNA IR-Double Strand Breaks (DSBs) and cellular response via ATM; G1 to S cell cycle control; DNA Damage Response; DNA Damage Response (only ATM dependent),TP53 Regulates Transcription of Caspase Activators and Caspases; Nonhomologous End-Joining (NHEJ); TP53 Regulates Transcription of DNA Repair Genes; Meiotic recombination; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Resolution of D-loop Structures through Holliday Junction Intermediates; G2/M DNA damage checkpoint; Regulation of HSF1-mediated heat shock response; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Regulation of TP53 Degradation; Presynaptic phase of homologous DNA pairing and strand exchange; Regulation of TP53 Activity through Methylation; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Autodegradation of the E3 ubiquitin ligase COP1; Sensing of DNA Double Strand Breaks; Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); DNA Damage/Telomere Stress Induced Senescence; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release,76,High,1
P27449,V-type proton ATPase 16 kDa proteolipid subunit OS=Homo sapiens OX=9606 GN=ATP6V0C PE=1 SV=1,0,19.849,12,1,30,1,155,15.7,8.44,14975,,1,,cellular homeostasis;regulation of biological process;response to stimulus;transport,membrane;vacuole,catalytic activity;protein binding;transporter activity,Pf00137,527,ENSG00000185883.11,ATP6V0C,16,Metabolic pathways; Tuberculosis; Synaptic vesicle cycle; Oxidative phosphorylation; Epithelial cell signaling in Helicobacter pylori infection; Vibrio cholerae infection; Phagosome; Rheumatoid arthritis; Lysosome; Collecting duct acid secretion,,"Transferrin endocytosis and recycling; ROS, RNS production in phagocytes; Ion channel transport; Insulin receptor recycling; Neutrophil degranulation",22,High,1
Q9Y5N5,Methyltransferase N6AMT1 OS=Homo sapiens OX=9606 GN=N6AMT1 PE=1 SV=4,0,19.848,27,5,13,5,214,22.9,5.11,3077,7.08,4,1,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol,catalytic activity;protein binding,"Pf01170, Pf05175, Pf08242, Pf13578, Pf13649, Pf13659, Pf13847",29104,ENSG00000156239.11,N6AMT1,21,,,,0,High,1
Q8IVJ1,Solute carrier family 41 member 1 OS=Homo sapiens OX=9606 GN=SLC41A1 PE=2 SV=2,0,19.84,12,3,4,2,513,54.9,5.3,1050,6.2,2,1,cellular homeostasis;response to stimulus;transport,membrane,transporter activity,Pf01769,254428,ENSG00000133065.10,SLC41A1,1,,,Metal ion SLC transporters,4,High,1
Q9Y4Z0,U6 snRNA-associated Sm-like protein LSm4 OS=Homo sapiens OX=9606 GN=LSM4 PE=1 SV=1,0,19.751,22,3,46,3,139,15.3,9.99,19177,,3,,cell organization and biogenesis;metabolic process,cytosol;membrane;nucleus;spliceosomal complex,protein binding;RNA binding,Pf01423,25804,ENSG00000130520.10,LSM4,19,Spliceosome; RNA degradation,,mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease,8,High,1
P17405,Sphingomyelin phosphodiesterase OS=Homo sapiens OX=9606 GN=SMPD1 PE=1 SV=5,0,19.731,7,4,14,4,631,69.9,7.28,6563,,4,,,,,,,,,,,,,0,High,1
Q9HD40,O-phosphoseryl-tRNA(Sec) selenium transferase OS=Homo sapiens OX=9606 GN=SEPSECS PE=1 SV=2,0,19.705,12,5,16,5,501,55.7,8.05,6282,,5,,metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;protein binding;RNA binding,Pf05889,51091,ENSG00000109618.11,SEPSECS,4,Selenocompound metabolism; Aminoacyl-tRNA biosynthesis,Selenium Metabolism and Selenoproteins,Selenocysteine synthesis,7,High,1
O60245,Protocadherin-7 OS=Homo sapiens OX=9606 GN=PCDH7 PE=1 SV=2,0,19.692,6,5,18,5,1069,116,5.19,6533,,5,,transport,membrane,metal ion binding,"Pf00028, Pf08266, Pf08374",5099,ENSG00000169851.15,PCDH7,4,,,Platelet degranulation,4,High,1
Q92843-2,Isoform 3 of Bcl-2-like protein 2 OS=Homo sapiens OX=9606 GN=BCL2L2,0,19.689,18,5,15,2,333,37.1,8.13,5370,,5,,cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus,protein binding;RNA binding,"Pf00076, Pf00452, Pf02180, Pf13893, Pf14259",599; 8106,ENSG00000258643.5,BCL2L2; PABPN1,14,,Apoptosis; Photodynamic therapy-induced NF-kB survival signaling; mRNA Processing,,3,High,1
P13473,Lysosome-associated membrane glycoprotein 2 OS=Homo sapiens OX=9606 GN=LAMP2 PE=1 SV=2,0,19.681,7,3,50,3,410,44.9,5.63,29815,,3,,cell communication;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,endosome;membrane;organelle lumen;vacuole,protein binding,Pf01299,3920,ENSG00000005893.15,LAMP2,X,Lysosome; Tuberculosis; Phagosome,Senescence and Autophagy in Cancer,Platelet degranulation ; Neutrophil degranulation,11,High,1
Q14532,"Keratin, type I cuticular Ha2 OS=Homo sapiens OX=9606 GN=KRT32 PE=2 SV=3",0,19.68,6,4,127,0,448,50.3,4.84,75426,0,4,1,cell death;cell organization and biogenesis,cytoskeleton;cytosol,catalytic activity;motor activity;structural molecule activity,"Pf00038, Pf01576, Pf05287, Pf06160, Pf12128, Pf13514",3882,ENSG00000108759.3,KRT32,17,,,Formation of the cornified envelope,3,Not Found,1
Q8NBR6,Ubiquitin carboxyl-terminal hydrolase MINDY-2 OS=Homo sapiens OX=9606 GN=MINDY2 PE=1 SV=2,0,19.678,13,5,10,5,621,67.1,4.51,3767,,5,,metabolic process,,catalytic activity;protein binding,Pf04424,54629,ENSG00000128923.10,FAM63B; MINDY2,15,,,,0,High,1
Q9H3P2,Negative elongation factor A OS=Homo sapiens OX=9606 GN=NELFA PE=1 SV=3,0,19.665,9,4,11,4,528,57.2,9.03,5042,,4,,development;metabolic process;regulation of biological process,cytosol;nucleus,protein binding,,7469,ENSG00000185049.14,NELFA; WHSC2,4,,Initiation of transcription and translation elongation at the HIV-1 LTR,HIV elongation arrest and recovery; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat; TP53 Regulates Transcription of DNA Repair Genes; Tat-mediated HIV elongation arrest and recovery; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase II Pre-transcription Events; Pausing and recovery of HIV elongation; Pausing and recovery of Tat-mediated HIV elongation; Formation of HIV-1 elongation complex containing HIV-1 Tat; Formation of the Early Elongation Complex,26,High,1
Q14728,Major facilitator superfamily domain-containing protein 10 OS=Homo sapiens OX=9606 GN=MFSD10 PE=1 SV=1,0,19.64,12,5,14,5,455,48.3,9.6,5453,,5,,cell death;transport,membrane,transporter activity,"Pf00083, Pf07690",10227,ENSG00000109736.14,MFSD10,4,,,,0,High,1
A0A0B4J1V6,Immunoglobulin heavy variable 3-73 OS=Homo sapiens OX=9606 GN=IGHV3-73 PE=3 SV=1,0,19.629,22,2,35,1,119,12.8,9.17,18604,,2,,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,protein binding,,28409,ENSG00000273539.3; ENSG00000211976.2,IGHV3-73,14; CHR_HSCHR14_3_CTG1,,,,0,High,1
A6NHX0,Cytosolic arginine sensor for mTORC1 subunit 2 OS=Homo sapiens OX=9606 GN=CASTOR2 PE=1 SV=3,0,19.608,19,4,9,3,329,36,5.16,3003,,4,,,cytoplasm;cytosol,protein binding,Pf13840,729438,ENSG00000274070.1,GATSL2; CASTOR2; GATSL1,7,,,,0,High,1
O60437,Periplakin OS=Homo sapiens OX=9606 GN=PPL PE=1 SV=4,0,19.598,4,7,47,7,1756,204.6,5.6,17854,,7,,cell death;cell organization and biogenesis;metabolic process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus,protein binding;structural molecule activity,Pf04111,5493,ENSG00000118898.15,PPL,16,,,Butyrophilin (BTN) family interactions; Formation of the cornified envelope,6,High,1
P09486,SPARC OS=Homo sapiens OX=9606 GN=SPARC PE=1 SV=1,0,19.58,16,3,16,3,303,34.6,4.84,5692,2,3,1,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;extracellular;membrane;mitochondrion;nucleus;organelle lumen,metal ion binding;protein binding,"Pf00050, Pf07648, Pf09289, Pf10591",6678,ENSG00000113140.10,SPARC,5,,miR-509-3p alteration of YAP1/ECM axis; Senescence and Autophagy in Cancer,Platelet degranulation ; ECM proteoglycans; Scavenging by Class H Receptors,11,High,1
Q8TEB1,DDB1- and CUL4-associated factor 11 OS=Homo sapiens OX=9606 GN=DCAF11 PE=1 SV=1,0,19.571,10,5,25,5,546,61.6,6.4,9911,,5,,metabolic process,,protein binding,Pf00400,80344,ENSG00000100897.17,DCAF11,14,,,Neddylation,3,High,1
Q96S82,Ubiquitin-like protein 7 OS=Homo sapiens OX=9606 GN=UBL7 PE=1 SV=2,0,19.57,16,4,16,4,380,40.5,5.07,5627,1.7,4,1,,,protein binding,"Pf00240, Pf00627, Pf11976",84993,ENSG00000138629.15,UBL7,15,,,,0,High,1
O94829,Importin-13 OS=Homo sapiens OX=9606 GN=IPO13 PE=1 SV=3,0,19.556,6,4,21,4,963,108.1,5.3,8552,,4,,transport,cytoplasm;membrane;nucleus,protein binding;transporter activity,"Pf03810, Pf08389",9670,ENSG00000117408.10,IPO13,1,,,,0,High,1
Q14966,Zinc finger protein 638 OS=Homo sapiens OX=9606 GN=ZNF638 PE=1 SV=2,0,19.528,3,6,18,6,1978,220.5,6.38,4733,,6,,metabolic process;regulation of biological process,cytoplasm;nucleus,DNA binding;metal ion binding;RNA binding,"Pf00076, Pf12171, Pf13893, Pf14259",27332,ENSG00000075292.18,ZNF638,2,,,Transcriptional regulation of white adipocyte differentiation,2,High,1
Q96BN8,Ubiquitin thioesterase otulin OS=Homo sapiens OX=9606 GN=OTULIN PE=1 SV=3,0,19.486,17,5,16,5,352,40.2,5.47,5167,,5,,defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,catalytic activity;protein binding,Pf10275,90268,ENSG00000154124.4,FAM105B; OTULIN,5,,,Regulation of TNFR1 signaling; Synthesis of active ubiquitin: roles of E1 and E2 enzymes,8,High,1
O94822,E3 ubiquitin-protein ligase listerin OS=Homo sapiens OX=9606 GN=LTN1 PE=1 SV=6,0,19.449,4,5,10,5,1766,200.4,6.25,3971,,5,,metabolic process,,catalytic activity;metal ion binding;protein binding,"Pf11793, Pf12678, Pf12861, Pf12906, Pf13639",26046,ENSG00000198862.13,LTN1,21,,,Antigen processing: Ubiquitination & Proteasome degradation,4,High,1
Q9BSJ5,Uncharacterized protein C17orf80 OS=Homo sapiens OX=9606 GN=C17orf80 PE=2 SV=2,0,19.444,10,4,26,4,609,67.3,9.16,7986,0,4,2,,membrane,,,55028,ENSG00000141219.15,C17orf80,17,,,,0,High,1
Q96S99,Pleckstrin homology domain-containing family F member 1 OS=Homo sapiens OX=9606 GN=PLEKHF1 PE=1 SV=3,0,19.407,26,4,24,4,279,31.2,8.24,10950,,4,,cell death;cell organization and biogenesis;regulation of biological process,cytoplasm;endosome;membrane;nucleus;vacuole,metal ion binding;protein binding,Pf01363,79156,ENSG00000166289.5,PLEKHF1,19,,,,0,High,1
P02461,Collagen alpha-1(III) chain OS=Homo sapiens OX=9606 GN=COL3A1 PE=1 SV=4,0,19.402,3,3,64,3,1466,138.5,6.61,26526,,3,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,extracellular;organelle lumen,metal ion binding;protein binding;structural molecule activity,"Pf00093, Pf01410, Pf14828",1281,ENSG00000168542.14,COL3A1,2,AGE-RAGE signaling pathway in diabetic complications; Platelet activation; Amoebiasis; Protein digestion and absorption,miRNA targets in ECM and membrane receptors; Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; miR-509-3p alteration of YAP1/ECM axis; Inflammatory Response Pathway; Senescence and Autophagy in Cancer,Collagen degradation; Integrin cell surface interactions; MET activates PTK2 signaling; Scavenging by Class A Receptors; Syndecan interactions; ECM proteoglycans; Assembly of collagen fibrils and other multimeric structures; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Collagen chain trimerization; Signaling by PDGF; NCAM1 interactions,37,High,1
Q5T011,KICSTOR complex protein SZT2 OS=Homo sapiens OX=9606 GN=SZT2 PE=1 SV=3,0,19.4,2,5,12,5,3432,377.8,6.27,4204,,5,,cell communication;cell organization and biogenesis;regulation of biological process;response to stimulus,membrane;vacuole,protein binding,,23334,ENSG00000198198.15,SZT2,1,,,,0,High,1
Q9Y5Q8,General transcription factor 3C polypeptide 5 OS=Homo sapiens OX=9606 GN=GTF3C5 PE=1 SV=2,0,19.386,12,5,13,5,519,59.5,6.9,5293,,5,,cell differentiation;cell organization and biogenesis;metabolic process,nucleus,DNA binding;protein binding,Pf09734,9328,ENSG00000148308.17,GTF3C5,9,,,RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter,6,High,1
Q14012,Calcium/calmodulin-dependent protein kinase type 1 OS=Homo sapiens OX=9606 GN=CAMK1 PE=1 SV=1,0,19.377,15,5,27,3,370,41.3,5.29,11481,,5,,cell differentiation;development;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf07714, Pf14531",8536,ENSG00000134072.10,CAMK1,3,Oxytocin signaling pathway; Aldosterone synthesis and secretion,Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Association Between Physico-Chemical Features and Toxicity Associated Pathways; Calcium Regulation in the Cardiac Cell,,5,High,1
Q5TA50,Ceramide-1-phosphate transfer protein OS=Homo sapiens OX=9606 GN=CPTP PE=1 SV=1,0,19.37,14,3,26,3,214,24.4,7.21,9404,,3,,metabolic process;transport,cytoplasm;cytosol;endosome;Golgi;membrane;nucleus,transporter activity,Pf08718,80772,ENSG00000224051.6,GLTPD1; CPTP,1,,,Glycosphingolipid metabolism,4,High,1
P60983,Glia maturation factor beta OS=Homo sapiens OX=9606 GN=GMFB PE=1 SV=2,0,19.35,26,4,62,3,142,16.7,5.29,25036,,4,,metabolic process;regulation of biological process;response to stimulus,,enzyme regulator activity;protein binding;signal transducer activity,Pf00241,2764,ENSG00000197045.12,GMFB,14,,,,0,High,1
Q9H477,Ribokinase OS=Homo sapiens OX=9606 GN=RBKS PE=1 SV=1,0,19.347,10,3,30,3,322,34.1,5.05,14519,1.81,3,1,metabolic process,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00294, Pf08543",64080,ENSG00000171174.13,RBKS,2,Pentose phosphate pathway,,Pentose phosphate pathway (hexose monophosphate shunt),4,High,1
Q05048,Cleavage stimulation factor subunit 1 OS=Homo sapiens OX=9606 GN=CSTF1 PE=1 SV=1,0,19.33,8,2,19,2,431,48.3,6.58,8292,,2,,metabolic process,nucleus,protein binding;RNA binding,"Pf00400, Pf11768",1477,ENSG00000101138.11,CSTF1,20,mRNA surveillance pathway,mRNA Processing,Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs; mRNA 3'-end processing; mRNA Splicing - Major Pathway,13,High,1
Q15262,Receptor-type tyrosine-protein phosphatase kappa OS=Homo sapiens OX=9606 GN=PTPRK PE=1 SV=2,0,19.327,5,5,24,4,1439,162,5.9,8865,0,4,1,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cell surface;membrane,catalytic activity;protein binding;receptor activity;signal transducer activity,"Pf00041, Pf00102, Pf00629, Pf00782, Pf07679, Pf13895, Pf14566",5796,ENSG00000273993.4; ENSG00000152894.14,PTPRK,6; CHR_HSCHR6_1_CTG8,,,EGFR downregulation,4,High,1
P50542,Peroxisomal targeting signal 1 receptor OS=Homo sapiens OX=9606 GN=PEX5 PE=1 SV=3,0,19.309,10,4,12,4,639,70.8,4.54,4403,,4,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;Golgi;membrane;organelle lumen,protein binding,"Pf00515, Pf13414, Pf13424, Pf13432",5830,ENSG00000139197.10,PEX5,12,Peroxisome,,E3 ubiquitin ligases ubiquitinate target proteins,5,High,1
Q8NHV1,GTPase IMAP family member 7 OS=Homo sapiens OX=9606 GN=GIMAP7 PE=1 SV=1,0,19.307,13,3,14,3,300,34.5,6.46,6409,,3,,metabolic process,cytoplasm;cytosol;endoplasmic reticulum;Golgi,catalytic activity;nucleotide binding;protein binding,"Pf01926, Pf04548",168537,ENSG00000179144.4,GIMAP7,7,,,,0,High,1
C9JLW8,Mapk-regulated corepressor-interacting protein 1 OS=Homo sapiens OX=9606 GN=MCRIP1 PE=1 SV=1,0,19.296,46,4,11,4,97,10.9,9.41,3890,1.81,3,1,regulation of biological process,cytoplasm;nucleus,protein binding,Pf14799,348262,ENSG00000225663.7,FAM195B; MCRIP1,17,,,,0,High,1
Q9BU23,Lipase maturation factor 2 OS=Homo sapiens OX=9606 GN=LMF2 PE=1 SV=2,0,19.295,10,5,12,5,707,79.6,10.1,4100,,5,,metabolic process,endoplasmic reticulum;membrane,protein binding,Pf06762,91289,ENSG00000100258.17,LMF2,22,,,Assembly of active LPL and LIPC lipase complexes,4,High,1
O75954,Tetraspanin-9 OS=Homo sapiens OX=9606 GN=TSPAN9 PE=1 SV=1,0,19.262,11,2,19,2,239,26.8,7.68,9606,0,2,1,regulation of biological process;response to stimulus,membrane,,Pf00335,10867,ENSG00000011105.12,TSPAN9,12,,,,0,High,1
Q9Y5J9,Mitochondrial import inner membrane translocase subunit Tim8 B OS=Homo sapiens OX=9606 GN=TIMM8B PE=1 SV=1,0,19.254,37,3,31,3,83,9.3,5.12,14816,,3,,transport,membrane;mitochondrion,metal ion binding;transporter activity,Pf02953,26521,ENSG00000150779.11,TIMM8B,11,,,Mitochondrial protein import; Metabolism of proteins,2,High,1
Q9BVT8,Transmembrane and ubiquitin-like domain-containing protein 1 OS=Homo sapiens OX=9606 GN=TMUB1 PE=1 SV=1,0,19.253,25,4,9,4,246,26.2,5.72,3941,,4,,metabolic process,cytoplasm;cytoskeleton;cytosol;endosome;membrane;nucleus,protein binding,"Pf00240, Pf10302, Pf13881",83590,ENSG00000164897.12,TMUB1,7,,,,0,High,1
Q13936,Voltage-dependent L-type calcium channel subunit alpha-1C OS=Homo sapiens OX=9606 GN=CACNA1C PE=1 SV=4,0,19.242,2,4,33,4,2221,248.8,6.76,7587,5.93,2,2,cell communication;cellular homeostasis;regulation of biological process;response to stimulus;transport,cytoplasm;membrane,metal ion binding;protein binding;transporter activity,"Pf00520, Pf08016, Pf08763",775,,CACNA1C,12,GABAergic synapse; Circadian entrainment; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Calcium signaling pathway; Taste transduction; cGMP-PKG signaling pathway; GnRH signaling pathway; Type II diabetes mellitus; Vascular smooth muscle contraction; Hypertrophic cardiomyopathy (HCM); Alzheimer's disease; Renin secretion; Cardiac muscle contraction; Long-term potentiation; Glutamatergic synapse; Aldosterone synthesis and secretion; MAPK signaling pathway; Dopaminergic synapse; cAMP signaling pathway; Insulin secretion; Dilated cardiomyopathy; Retrograde endocannabinoid signaling; Oxytocin signaling pathway; Serotonergic synapse; Cholinergic synapse; Adrenergic signaling in cardiomyocytes; Amphetamine addiction,Nicotine Activity on Chromaffin Cells; Alzheimers Disease; Arrhythmogenic Right Ventricular Cardiomyopathy; Calcium Regulation in the Cardiac Cell,"Adrenaline,noradrenaline inhibits insulin secretion; Phase 0 - rapid depolarisation; NCAM1 interactions; Phase 2 - plateau phase",43,High,1
Q8TEV9,Guanine nucleotide exchange protein SMCR8 OS=Homo sapiens OX=9606 GN=SMCR8 PE=1 SV=2,0,19.227,7,5,10,5,937,105,5.58,2531,2.07,4,1,metabolic process;regulation of biological process,chromosome;cytoplasm;nucleus,enzyme regulator activity;protein binding,,140775,ENSG00000176994.10; ENSG00000283741.1,SMCR8,17; CHR_HSCHR17_3_CTG1,,,,0,High,1
P35030,Trypsin-3 OS=Homo sapiens OX=9606 GN=PRSS3 PE=1 SV=2,0,19.226,7,3,22,2,304,32.5,7.49,10443,,3,,cellular component movement;metabolic process;response to stimulus;transport,extracellular,catalytic activity;metal ion binding;protein binding,Pf00089,5646,ENSG00000010438.16,PRSS3,9,Protein digestion and absorption; Pancreatic secretion; Influenza A; Neuroactive ligand-receptor interaction,,"Alpha-defensins; Cobalamin (Cbl, vitamin B12) transport and metabolism; Neutrophil degranulation",14,High,1
Q9H9S3,Protein transport protein Sec61 subunit alpha isoform 2 OS=Homo sapiens OX=9606 GN=SEC61A2 PE=2 SV=3,0,19.21,9,5,33,1,476,52.2,8.06,12129,0,5,1,transport,cytosol;endoplasmic reticulum;membrane,,"Pf00344, Pf10559",55176,ENSG00000065665.20,SEC61A2,10,Phagosome; Protein export; Vibrio cholerae infection; Protein processing in endoplasmic reticulum,,ER-Phagosome pathway; XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane,15,High,1
O15484,Calpain-5 OS=Homo sapiens OX=9606 GN=CAPN5 PE=1 SV=2,0,19.205,7,3,13,3,640,73.1,7.64,6008,,3,,metabolic process;regulation of biological process;response to stimulus,cell surface;cytoplasm,catalytic activity;protein binding,"Pf00168, Pf00648, Pf01067",726,ENSG00000149260.15,CAPN5,11,,Integrin-mediated Cell Adhesion,Degradation of the extracellular matrix,3,High,1
Q9NXW2,DnaJ homolog subfamily B member 12 OS=Homo sapiens OX=9606 GN=DNAJB12 PE=1 SV=5,0,19.203,15,4,12,4,375,41.8,8.69,5137,,4,,cell organization and biogenesis;metabolic process;response to stimulus,endoplasmic reticulum;membrane,protein binding,"Pf00226, Pf09320",54788,ENSG00000148719.14,DNAJB12,10,,,,0,High,1
P51809,Vesicle-associated membrane protein 7 OS=Homo sapiens OX=9606 GN=VAMP7 PE=1 SV=3,0,19.2,20,3,12,3,220,24.9,8.6,6202,,3,,cell organization and biogenesis;cellular component movement;regulation of biological process;transport,cell surface;cytoplasm;endoplasmic reticulum;endosome;Golgi;membrane;vacuole,protein binding,"Pf00957, Pf13774",6845,ENSG00000124333.15,VAMP7,X|Y; X,SNARE interactions in vesicular transport,,Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; Interleukin-12 family signaling; Lysosome Vesicle Biogenesis,13,High,1
Q08AF3,Schlafen family member 5 OS=Homo sapiens OX=9606 GN=SLFN5 PE=1 SV=1,0,19.191,4,4,15,3,891,101,8.22,5176,,4,,cell differentiation,nucleus,nucleotide binding,"Pf04326, Pf09848, Pf13401, Pf13538",162394,ENSG00000166750.9,SLFN5,17,,,,0,High,1
Q7Z7H8,"39S ribosomal protein L10, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL10 PE=1 SV=3",0,19.175,15,3,19,3,261,29.3,9.58,9026,,3,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,protein binding;RNA binding;structural molecule activity,Pf00466,124995,ENSG00000159111.12,MRPL10,17,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
Q9Y3C4,EKC/KEOPS complex subunit TPRKB OS=Homo sapiens OX=9606 GN=TPRKB PE=1 SV=1,0,19.173,22,3,22,3,175,19.6,6.79,14083,,3,,metabolic process,cytoplasm;cytosol;nucleus,protein binding,Pf08617,51002,ENSG00000144034.14,TPRKB,2,,,tRNA modification in the nucleus and cytosol,3,High,1
Q8N3U4,Cohesin subunit SA-2 OS=Homo sapiens OX=9606 GN=STAG2 PE=1 SV=3,0,19.145,6,6,15,3,1231,141.2,5.43,5994,,6,,cell division;cell organization and biogenesis;regulation of biological process,chromosome;cytosol;membrane;nucleus,protein binding,"Pf00670, Pf08514",10735,ENSG00000101972.18,STAG2,X,Cell cycle,,Meiotic synapsis; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin; Establishment of Sister Chromatid Cohesion; SUMOylation of DNA damage response and repair proteins,21,High,1
O60547,"GDP-mannose 4,6 dehydratase OS=Homo sapiens OX=9606 GN=GMDS PE=1 SV=1",0,19.143,18,5,19,5,372,41.9,7.31,6165,0,5,1,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,catalytic activity;nucleotide binding;protein binding,"Pf01370, Pf04321, Pf13460",2762,ENSG00000112699.10,GMDS,6,Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Fructose and mannose metabolism,,GDP-fucose biosynthesis,9,High,1
Q12996,Cleavage stimulation factor subunit 3 OS=Homo sapiens OX=9606 GN=CSTF3 PE=1 SV=1,0,19.102,9,4,27,4,717,82.9,8.12,10965,,4,,metabolic process,nucleus,protein binding;RNA binding,Pf05843,1479,ENSG00000176102.11,CSTF3,11,mRNA surveillance pathway,mRNA Processing,Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs; mRNA 3'-end processing; mRNA Splicing - Major Pathway,13,High,1
O95456,Proteasome assembly chaperone 1 OS=Homo sapiens OX=9606 GN=PSMG1 PE=1 SV=1,0,19.079,9,2,19,2,288,32.8,7.17,10167,,2,,cell organization and biogenesis;cell proliferation,cytoplasm;cytosol;endoplasmic reticulum;Golgi;nucleus,protein binding,,8624,ENSG00000183527.11,PSMG1,21,,,,0,High,1
Q7Z7K6,Centromere protein V OS=Homo sapiens OX=9606 GN=CENPV PE=1 SV=1,0,19.068,27,5,27,5,275,29.9,9.73,14143,,5,,cell division;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process,chromosome;cytoplasm;cytoskeleton;cytosol;nucleus,catalytic activity,Pf04828,201161,,CENPV,17,,,,0,High,1
Q70HW3,S-adenosylmethionine mitochondrial carrier protein OS=Homo sapiens OX=9606 GN=SLC25A26 PE=1 SV=2,0,19.059,14,3,26,3,274,29.3,9.35,12982,,3,,,,,,,,,,,,,0,High,1
Q92504,Zinc transporter SLC39A7 OS=Homo sapiens OX=9606 GN=SLC39A7 PE=1 SV=2,0,19.048,4,1,6,1,469,50.1,6.87,2692,,1,,cellular homeostasis;transport,endoplasmic reticulum;Golgi;membrane,protein binding;transporter activity,Pf02535,7922,ENSG00000227402.11; ENSG00000112473.17; ENSG00000206288.13; ENSG00000226614.11; ENSG00000224399.11; ENSG00000229802.11,SLC39A7,6; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_DBB_CTG1,,NRF2 pathway; Zinc homeostasis,Zinc influx into cells by the SLC39 gene family,8,High,1
Q9UM54-1,Isoform 1 of Unconventional myosin-VI OS=Homo sapiens OX=9606 GN=MYO6,0,18.993,4,5,11,5,1285,148.6,8.53,3637,,5,,cellular component movement;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;Golgi;membrane;nucleus,catalytic activity;motor activity;nucleotide binding;protein binding,"Pf00063, Pf05835",4646,ENSG00000196586.13,MYO6,6,,VEGFA-VEGFR2 Signaling Pathway,,1,High,1
Q8N684,Cleavage and polyadenylation specificity factor subunit 7 OS=Homo sapiens OX=9606 GN=CPSF7 PE=1 SV=1,0,18.959,14,5,23,5,471,52,8,10083,,5,,cell organization and biogenesis;metabolic process,membrane;nucleus,protein binding;RNA binding,"Pf00076, Pf14259",79869,ENSG00000149532.15,CPSF7,11,mRNA surveillance pathway,,Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs; mRNA 3'-end processing; mRNA Splicing - Major Pathway,12,High,1
Q9C0B1,Alpha-ketoglutarate-dependent dioxygenase FTO OS=Homo sapiens OX=9606 GN=FTO PE=1 SV=3,0,18.946,9,5,21,5,505,58.2,5.22,8773,,5,,metabolic process;regulation of biological process;response to stimulus,nucleus,catalytic activity;metal ion binding,"Pf12933, Pf12934",79068,ENSG00000140718.20,FTO,16,,FTO Obesity Variant Mechanism,Reversal of alkylation damage by DNA dioxygenases,4,High,1
Q9Y3C0,WASH complex subunit 3 OS=Homo sapiens OX=9606 GN=WASHC3 PE=1 SV=1,0,18.937,44,5,19,5,194,21.2,4.46,8031,,5,,transport,endosome,protein binding,Pf10152,51019,ENSG00000120860.10,CCDC53; WASHC3,12,Endocytosis,,,1,High,1
Q9Y2R5,"28S ribosomal protein S17, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS17 PE=1 SV=1",0,18.933,22,3,57,3,130,14.5,9.85,27296,,3,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,RNA binding;structural molecule activity,Pf00366,51373,ENSG00000239789.5,MRPS17,7,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
Q6DN90,IQ motif and SEC7 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=IQSEC1 PE=1 SV=1,0,18.926,6,5,11,5,963,108.2,6.93,4957,,5,,cell organization and biogenesis;regulation of biological process,cytoplasm;membrane;nucleus,protein binding,Pf01369,9922,ENSG00000144711.13,IQSEC1,3,Endocytosis,EGF/EGFR Signaling Pathway,,2,High,1
Q9NT22,EMILIN-3 OS=Homo sapiens OX=9606 GN=EMILIN3 PE=1 SV=2,0,18.911,8,4,10,4,766,82.6,7.72,4370,,4,,cell organization and biogenesis,cytoplasm;cytoskeleton;extracellular,protein binding,"Pf06160, Pf07546",90187,ENSG00000183798.4,EMILIN3,20,,,Molecules associated with elastic fibres,3,High,1
P45973,Chromobox protein homolog 5 OS=Homo sapiens OX=9606 GN=CBX5 PE=1 SV=1,0,18.903,13,3,9,3,191,22.2,5.86,4504,,3,,coagulation;regulation of biological process,chromosome;nucleus,protein binding,"Pf00385, Pf01393",23468,ENSG00000094916.15,CBX5,12,,,SUMOylation of chromatin organization proteins; Factors involved in megakaryocyte development and platelet production; Transcriptional Regulation by E2F6,11,High,1
O95197,Reticulon-3 OS=Homo sapiens OX=9606 GN=RTN3 PE=1 SV=2,0,18.885,1,2,47,2,1032,112.5,4.96,21028,,2,,cell death;cell organization and biogenesis;regulation of biological process;transport,endoplasmic reticulum;Golgi;membrane,protein binding,"Pf02453, Pf04093",10313,ENSG00000133318.13,RTN3,11,Alzheimer's disease,,Synaptic adhesion-like molecules,4,High,1
Q9H9Q2,COP9 signalosome complex subunit 7b OS=Homo sapiens OX=9606 GN=COPS7B PE=1 SV=1,0,18.885,16,3,29,3,264,29.6,6.15,14052,,3,,cell organization and biogenesis;metabolic process;response to stimulus,cytoplasm;cytosol;nucleus,protein binding,Pf01399,64708,ENSG00000144524.17,COPS7B,2,,,Cargo recognition for clathrin-mediated endocytosis; DNA Damage Recognition in GG-NER; Formation of TC-NER Pre-Incision Complex; Neddylation,13,High,1
O14929,Histone acetyltransferase type B catalytic subunit OS=Homo sapiens OX=9606 GN=HAT1 PE=1 SV=1,0,18.883,10,2,12,2,419,49.5,5.69,6092,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,catalytic activity;protein binding,Pf10394,8520,,HAT1,2,Alcoholism,,HATs acetylate histones,4,High,1
Q13438,Protein OS-9 OS=Homo sapiens OX=9606 GN=OS9 PE=1 SV=1,0,18.868,12,6,18,6,667,75.5,4.87,5797,,6,,metabolic process;response to stimulus;transport,endoplasmic reticulum;membrane;organelle lumen,protein binding,Pf07915,10956,ENSG00000135506.15,OS9,12,Protein processing in endoplasmic reticulum,,Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; ER Quality Control Compartment (ERQC); ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Hedgehog ligand biogenesis,19,High,1
P80511,Protein S100-A12 OS=Homo sapiens OX=9606 GN=S100A12 PE=1 SV=2,0,18.865,20,1,28,1,92,10.6,6.25,15908,,1,,cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen,metal ion binding;protein binding,"Pf01023, Pf13499",6283,ENSG00000163221.8,S100A12,1,,,TRAF6 mediated NF-kB activation; Advanced glycosylation endproduct receptor signaling; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; RIP-mediated NFkB activation via ZBP1; Activated TLR4 signalling; Interleukin-1 family signaling; Neutrophil degranulation; DEx/H-box helicases activate type I IFN and inflammatory cytokines production,31,High,1
O00267,Transcription elongation factor SPT5 OS=Homo sapiens OX=9606 GN=SUPT5H PE=1 SV=1,0,18.845,5,4,14,4,1087,120.9,5.06,5682,,4,,cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus,nucleus,DNA binding;protein binding;RNA binding,"Pf00467, Pf03439, Pf04731, Pf07223, Pf11029, Pf11942, Pf12815",6829,ENSG00000196235.13,SUPT5H,19,,Initiation of transcription and translation elongation at the HIV-1 LTR; mRNA Processing,RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; Formation of HIV-1 elongation complex containing HIV-1 Tat; HIV elongation arrest and recovery; RNA Pol II CTD phosphorylation and interaction with CE; Formation of the HIV-1 Early Elongation Complex; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase II Pre-transcription Events; Pausing and recovery of Tat-mediated HIV elongation; Formation of the Early Elongation Complex,32,High,1
Q8IZ07,Ankyrin repeat domain-containing protein 13A OS=Homo sapiens OX=9606 GN=ANKRD13A PE=1 SV=3,0,18.842,11,5,19,5,590,67.6,5.02,5927,,5,,,cytoplasm;endosome;membrane,protein binding,"Pf00023, Pf11904, Pf12796, Pf13606, Pf13637, Pf13857",88455,ENSG00000076513.16,ANKRD13A,12,,,,0,High,1
Q9UBM7,7-dehydrocholesterol reductase OS=Homo sapiens OX=9606 GN=DHCR7 PE=1 SV=1,0,18.838,10,4,20,4,475,54.5,8.7,8446,0,4,1,cell differentiation;metabolic process;regulation of biological process,cytosol;endoplasmic reticulum;membrane,catalytic activity;nucleotide binding,Pf01222,1717,ENSG00000172893.15,DHCR7,11,Steroid biosynthesis; Metabolic pathways,Vitamin D Metabolism; Cholesterol Biosynthesis,Cholesterol biosynthesis via desmosterol; Cholesterol biosynthesis via lathosterol; Activation of gene expression by SREBF (SREBP),12,High,1
P61952,Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 OS=Homo sapiens OX=9606 GN=GNG11 PE=1 SV=1,0,18.808,44,4,18,4,73,8.5,5.54,6630,,4,,regulation of biological process;response to stimulus,membrane,catalytic activity;protein binding;signal transducer activity,Pf00631,2791,ENSG00000127920.5,GNG11,7,Circadian entrainment; Chemokine signaling pathway; Dopaminergic synapse; GABAergic synapse; Morphine addiction; Serotonergic synapse; PI3K-Akt signaling pathway; Ras signaling pathway; Retrograde endocannabinoid signaling; Cholinergic synapse; Alcoholism; Pathways in cancer; Glutamatergic synapse,Myometrial Relaxation and Contraction Pathways; G Protein Signaling Pathways; Chemokine signaling pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Calcium Regulation in the Cardiac Cell,"G alpha (z) signalling events; G alpha (12/13) signalling events; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G alpha (s) signalling events; Glucagon-type ligand receptors; Ca2+ pathway; Thromboxane signalling through TP receptor; ADP signalling through P2Y purinoceptor 1; ADP signalling through P2Y purinoceptor 12; Adrenaline,noradrenaline inhibits insulin secretion; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Presynaptic function of Kainate receptors; G beta:gamma signalling through PLC beta; Vasopressin regulates renal water homeostasis via Aquaporins; Glucagon signaling in metabolic regulation; Thrombin signalling through proteinase activated receptors (PARs); Prostacyclin signalling through prostacyclin receptor; G-protein activation; Gastrin-CREB signalling pathway via PKC and MAPK",65,High,1
Q9NYJ1,"Cytochrome c oxidase assembly factor 4 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=COA4 PE=1 SV=2",0,18.786,32,3,24,3,87,10.1,6.04,10404,,3,,cell organization and biogenesis,mitochondrion,,Pf06747,51287,ENSG00000181924.6,COA4,11,,,Mitochondrial protein import; Metabolism of proteins,2,High,1
P61328,Fibroblast growth factor 12 OS=Homo sapiens OX=9606 GN=FGF12 PE=1 SV=1,0,18.784,15,3,82,3,243,27.4,9.96,41041,,3,,cell communication;metabolic process;regulation of biological process;response to stimulus,nucleus,protein binding,Pf00167,2257,ENSG00000114279.13,FGF12,3,MAPK signaling pathway; Melanoma; Ras signaling pathway; Breast cancer; Rap1 signaling pathway; PI3K-Akt signaling pathway; Regulation of actin cytoskeleton; Pathways in cancer,ESC Pluripotency Pathways; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Regulation of Actin Cytoskeleton,Phase 0 - rapid depolarisation,14,High,1
P46776,60S ribosomal protein L27a OS=Homo sapiens OX=9606 GN=RPL27A PE=1 SV=2,0,18.778,20,3,94,3,148,16.6,11,43344,,3,,cell organization and biogenesis;metabolic process;transport,cytosol;endoplasmic reticulum;membrane;ribosome,protein binding;RNA binding;structural molecule activity,Pf00828,6157,ENSG00000166441.12,RPL27A,11,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
Q9HB21,Pleckstrin homology domain-containing family A member 1 OS=Homo sapiens OX=9606 GN=PLEKHA1 PE=1 SV=2,0,18.776,16,5,18,5,404,45.5,8.56,6714,3.79,4,1,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,protein binding,"Pf00169, Pf15409, Pf15413",59338,ENSG00000107679.14,PLEKHA1,10,,,Synthesis of PIPs at the plasma membrane,5,High,1
Q9BRA0,"N-alpha-acetyltransferase 38, NatC auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA38 PE=1 SV=1",0,18.74,23,2,12,2,125,13.5,5.53,5875,,2,,regulation of biological process,cytoplasm;nucleus,protein binding,Pf01423,84316,ENSG00000183011.13,LSMD1; NAA38,17,,,Retrograde transport at the Trans-Golgi-Network,4,High,1
Q96C01,Protein FAM136A OS=Homo sapiens OX=9606 GN=FAM136A PE=1 SV=1,0,18.731,18,3,68,3,138,15.6,7.61,27183,,3,,,cytoplasm,,Pf05811,84908,ENSG00000035141.7,FAM136A,2,,,,0,High,1
Q969T3,Sorting nexin-21 OS=Homo sapiens OX=9606 GN=SNX21 PE=2 SV=1,0,18.728,12,3,13,3,373,41.3,5.24,4976,,3,,transport,endosome;membrane,protein binding,"Pf00515, Pf00787, Pf13424",90203,ENSG00000124104.18,SNX21,20,,,,0,High,1
Q9BX40,Protein LSM14 homolog B OS=Homo sapiens OX=9606 GN=LSM14B PE=1 SV=1,0,18.723,17,3,8,3,385,42,9.69,3578,,3,,development;regulation of biological process,,RNA binding,"Pf09532, Pf12701, Pf14438",149986,ENSG00000149657.19,LSM14B,20,,,,0,High,1
P18440,Arylamine N-acetyltransferase 1 OS=Homo sapiens OX=9606 GN=NAT1 PE=1 SV=2,0,18.702,11,3,20,3,290,33.9,6.54,10043,,3,,metabolic process,cytoplasm;cytosol,catalytic activity,Pf00797,9,ENSG00000171428.13,NAT1,8,Drug metabolism - other enzymes; Chemical carcinogenesis; Metabolic pathways; Caffeine metabolism,Arylamine metabolism; Metapathway biotransformation,Acetylation,10,High,1
Q7L8W6,Diphthine--ammonia ligase OS=Homo sapiens OX=9606 GN=DPH6 PE=1 SV=3,0,18.691,22,4,17,4,267,30.3,5.4,6609,,4,,metabolic process;regulation of biological process,cytosol;nucleus,catalytic activity;nucleotide binding,Pf01902,89978,ENSG00000134146.11,ATPBD4; DPH6,15,,,Synthesis of diphthamide-EEF2,4,High,1
Q9GZQ3,COMM domain-containing protein 5 OS=Homo sapiens OX=9606 GN=COMMD5 PE=1 SV=1,0,18.674,21,4,21,4,224,24.7,7.02,6035,0,4,1,metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,protein binding,Pf07258,28991,ENSG00000170619.9,COMMD5,8,,,Neddylation,3,High,1
Q9UQN3,Charged multivesicular body protein 2b OS=Homo sapiens OX=9606 GN=CHMP2B PE=1 SV=1,0,18.652,15,4,46,4,213,23.9,8.76,18707,0,4,1,cell communication;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane;vacuole,protein binding,Pf03357,25978,ENSG00000083937.8,CHMP2B,3,Endocytosis,,Budding and maturation of HIV virion; Macroautophagy; Endosomal Sorting Complex Required For Transport (ESCRT),12,High,1
O75787,Renin receptor OS=Homo sapiens OX=9606 GN=ATP6AP2 PE=1 SV=2,0,18.643,21,5,14,5,350,39,6.1,5251,,5,,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,membrane,protein binding;receptor activity;transporter activity,Pf07850,10159,ENSG00000182220.14,ATP6AP2,X,Renin-angiotensin system,ACE Inhibitor Pathway; Oxidative phosphorylation,Metabolism of Angiotensinogen to Angiotensins; Neutrophil degranulation,9,High,1
Q96I25,Splicing factor 45 OS=Homo sapiens OX=9606 GN=RBM17 PE=1 SV=1,0,18.643,21,5,17,5,401,44.9,5.97,5686,,5,,metabolic process;regulation of biological process;response to stimulus,nucleus;spliceosomal complex,protein binding;RNA binding,"Pf00076, Pf01585, Pf13893, Pf14259",84991,ENSG00000134453.15,RBM17,10,Spliceosome,mRNA Processing,mRNA Splicing - Major Pathway,6,High,1
Q9H792,Inactive tyrosine-protein kinase PEAK1 OS=Homo sapiens OX=9606 GN=PEAK1 PE=1 SV=4,0,18.622,4,5,11,5,1746,193,6.89,3778,,5,,cell organization and biogenesis;cellular component movement;metabolic process,cytoplasm;cytoskeleton,catalytic activity;nucleotide binding;protein binding,Pf00069,79834,ENSG00000173517.10,PEAK1,15,,,,0,High,1
Q13459,Unconventional myosin-IXb OS=Homo sapiens OX=9606 GN=MYO9B PE=1 SV=3,0,18.603,3,5,7,5,2157,243.2,8.75,2571,,5,,cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane,catalytic activity;enzyme regulator activity;metal ion binding;motor activity;nucleotide binding;protein binding;structural molecule activity,"Pf00063, Pf00130, Pf00612, Pf00620, Pf00788, Pf06070",4650,,MYO9B,19,,,SLIT2:ROBO1 increases RHOA activity; Regulation of actin dynamics for phagocytic cup formation; Rho GTPase cycle,11,High,1
P29317,Ephrin type-A receptor 2 OS=Homo sapiens OX=9606 GN=EPHA2 PE=1 SV=2,0,18.597,5,4,61,4,976,108.2,6.23,24098,,4,,cell death;cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;defense response;development;metabolic process;regulation of biological process;response to stimulus,cell surface;membrane,catalytic activity;nucleotide binding;protein binding;receptor activity;signal transducer activity,"Pf00041, Pf00069, Pf00536, Pf01404, Pf07647, Pf07699, Pf07714, Pf09294, Pf14575",1969,ENSG00000142627.12,EPHA2,1,Axon guidance; Ras signaling pathway; PI3K-Akt signaling pathway; Rap1 signaling pathway,NRF2 pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,EPH-ephrin mediated repulsion of cells; EPHA-mediated growth cone collapse,11,High,1
Q9Y6K9,NF-kappa-B essential modulator OS=Homo sapiens OX=9606 GN=IKBKG PE=1 SV=2,0,18.59,17,4,12,4,419,48.2,5.71,3708,,4,,cell death;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,metal ion binding;protein binding;signal transducer activity,"Pf04111, Pf11577, Pf12128, Pf13851, Pf14362",8517,ENSG00000269335.5,IKBKG,X,Hepatitis B; Toll-like receptor signaling pathway; Primary immunodeficiency; HTLV-I infection; MAPK signaling pathway; Adipocytokine signaling pathway; Chronic myeloid leukemia; Hepatitis C; NOD-like receptor signaling pathway; Cytosolic DNA-sensing pathway; Chagas disease (American trypanosomiasis); Prostate cancer; Shigellosis; B cell receptor signaling pathway; Epithelial cell signaling in Helicobacter pylori infection; T cell receptor signaling pathway; Toxoplasmosis; Antifolate resistance; Ras signaling pathway; Th1 and Th2 cell differentiation; NF-kappa B signaling pathway; Pancreatic cancer; Herpes simplex infection; Viral carcinogenesis; Pathways in cancer; PI3K-Akt signaling pathway; Osteoclast differentiation; Small cell lung cancer; Acute myeloid leukemia; Chemokine signaling pathway; TNF signaling pathway; Apoptosis; Epstein-Barr virus infection; RIG-I-like receptor signaling pathway,Nucleotide-binding Oligomerization Domain (NOD) pathway; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; Leptin signaling pathway; IL17 signaling pathway; B Cell Receptor Signaling Pathway; TNF alpha Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Apoptosis; EBV LMP1 signaling; Cardiac Hypertrophic Response; NLR Proteins; Rac1/Pak1/p38/MMP-2 pathway; MAPK Signaling Pathway; MAPK  and NFkB Signalling Pathways Inhibited by Yersinia YopJ; Toll-like Receptor Signaling; T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection; RIG-I-like Receptor Signaling; ATM Signaling Network in Development and Disease; Chemokine signaling pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; T-Cell antigen Receptor (TCR)  Signaling Pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway,"IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); Downstream TCR signaling; NOD1/2 Signaling Pathway; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; TRAF6 mediated NF-kB activation; TICAM1, RIP1-mediated IKK complex recruitment ; Ovarian tumor domain proteases; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TNFR1-induced NFkappaB signaling pathway; RIP-mediated NFkB activation via ZBP1; Activated TLR4 signalling; Interleukin-1 family signaling; IRAK1 recruits IKK complex; activated TAK1 mediates p38 MAPK activation; Ub-specific processing proteases; IKBKB deficiency causes SCID; IKK complex recruitment mediated by RIP1; ER-Phagosome pathway; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; Regulation of TNFR1 signaling; IkBA variant leads to EDA-ID; CLEC7A (Dectin-1) signaling",129,High,1
Q16602,Calcitonin gene-related peptide type 1 receptor OS=Homo sapiens OX=9606 GN=CALCRL PE=1 SV=2,0,18.588,7,2,13,2,461,52.9,6.74,5322,8.82,2,1,metabolic process;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;endosome;membrane;vacuole,protein binding;receptor activity;signal transducer activity;transporter activity,"Pf00002, Pf02793",10203,,CALCRL,2,Vascular smooth muscle contraction; Neuroactive ligand-receptor interaction,"Endothelin Pathways; GPCRs, Class B Secretin-like",G alpha (s) signalling events; Calcitonin-like ligand receptors,11,High,1
Q6PCE3,"Glucose 1,6-bisphosphate synthase OS=Homo sapiens OX=9606 GN=PGM2L1 PE=1 SV=3",0,18.575,10,5,24,5,622,70.4,7.15,7054,,5,,metabolic process,cytosol,catalytic activity;metal ion binding,"Pf00408, Pf02878, Pf02879, Pf02880",283209,ENSG00000165434.7,PGM2L1,11,Starch and sucrose metabolism,,Glycolysis; Galactose catabolism; Glycogen breakdown (glycogenolysis); Glycogen synthesis,9,High,1
Q9NXV6,CDKN2A-interacting protein OS=Homo sapiens OX=9606 GN=CDKN2AIP PE=1 SV=3,0,18.57,8,4,9,4,580,61.1,9.01,4038,,4,,regulation of biological process;response to stimulus,nucleus,protein binding;RNA binding,Pf11952,55602,ENSG00000168564.5,CDKN2AIP,4,,,,0,High,1
Q9BUB5,MAP kinase-interacting serine/threonine-protein kinase 1 OS=Homo sapiens OX=9606 GN=MKNK1 PE=1 SV=1,0,18.554,7,2,5,2,465,51.3,6.68,2826,,2,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf07714",8569,ENSG00000079277.19,MKNK1,1,HIF-1 signaling pathway; MAPK signaling pathway; Insulin signaling pathway,"Structural Pathway of Interleukin 1 (IL-1); BDNF-TrkB Signaling; MAPK Signaling Pathway; 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression; VEGFA-VEGFR2 Signaling Pathway; p38 MAPK Signaling Pathway",Spry regulation of FGF signaling,21,High,1
Q5VT52,Regulation of nuclear pre-mRNA domain-containing protein 2 OS=Homo sapiens OX=9606 GN=RPRD2 PE=1 SV=1,0,18.553,5,5,10,5,1461,155.9,7.42,3798,,5,,metabolic process,,,Pf04818,23248,ENSG00000163125.15,RPRD2,1,,,RNA polymerase II transcribes snRNA genes,3,High,1
Q5VTR2,E3 ubiquitin-protein ligase BRE1A OS=Homo sapiens OX=9606 GN=RNF20 PE=1 SV=2,0,18.551,4,3,22,2,975,113.6,5.94,6624,,3,,cell organization and biogenesis;metabolic process;regulation of biological process,nucleus,catalytic activity;metal ion binding;protein binding;RNA binding,"Pf00097, Pf13639, Pf13920, Pf13923, Pf14634",56254,ENSG00000155827.11,RNF20,9,,ATM Signaling Network in Development and Disease,E3 ubiquitin ligases ubiquitinate target proteins,5,High,1
Q8WVM7,Cohesin subunit SA-1 OS=Homo sapiens OX=9606 GN=STAG1 PE=1 SV=3,0,18.542,5,6,32,3,1258,144.3,5.59,10701,,6,,cell division;cell organization and biogenesis;metabolic process;regulation of biological process,chromosome;cytosol;nucleus,protein binding,Pf08514,10274,ENSG00000118007.12,STAG1,3,Cell cycle,,Meiotic synapsis; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin; Establishment of Sister Chromatid Cohesion; SUMOylation of DNA damage response and repair proteins,21,High,1
O43670,BUB3-interacting and GLEBS motif-containing protein ZNF207 OS=Homo sapiens OX=9606 GN=ZNF207 PE=1 SV=1,0,18.511,10,4,14,4,478,50.7,9.1,6736,,4,,cell division;cell organization and biogenesis;regulation of biological process,chromosome;cytoplasm;cytoskeleton;nucleus,DNA binding;metal ion binding;protein binding;RNA binding,,7756,ENSG00000010244.18,ZNF207,17,,,,0,High,1
Q86W42,THO complex subunit 6 homolog OS=Homo sapiens OX=9606 GN=THOC6 PE=1 SV=1,0,18.463,18,4,9,4,341,37.5,7.43,3463,,4,,cell death;development;metabolic process;regulation of biological process;transport,nucleus,protein binding;RNA binding,Pf00400,79228,ENSG00000131652.13,THOC6,16,RNA transport,,Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing,10,High,1
Q9UNN8,Endothelial protein C receptor OS=Homo sapiens OX=9606 GN=PROCR PE=1 SV=1,0,18.427,15,3,18,3,238,26.7,7.18,7679,,3,,cellular component movement;coagulation;regulation of biological process,cell surface;extracellular;membrane,protein binding;receptor activity,Pf00129,10544,ENSG00000101000.5,PROCR,20,Complement and coagulation cascades,,Common Pathway of Fibrin Clot Formation; Cell surface interactions at the vascular wall,5,High,1
P15144,Aminopeptidase N OS=Homo sapiens OX=9606 GN=ANPEP PE=1 SV=4,0,18.385,6,4,10,4,967,109.5,5.48,4788,,4,,cell communication;cell differentiation;development;metabolic process;regulation of biological process;response to stimulus;transport,membrane;nucleus,catalytic activity;metal ion binding;receptor activity,"Pf01433, Pf10023, Pf11838, Pf13485",290,ENSG00000166825.13,ANPEP,15,Renin-angiotensin system; Glutathione metabolism; Metabolic pathways; Hematopoietic cell lineage,Glutathione metabolism; Cardiac Progenitor Differentiation,Metabolism of Angiotensinogen to Angiotensins; Neutrophil degranulation,12,High,1
Q8IWU2,Serine/threonine-protein kinase LMTK2 OS=Homo sapiens OX=9606 GN=LMTK2 PE=1 SV=2,0,18.373,4,5,11,5,1503,164.8,4.48,2946,0,5,1,metabolic process;regulation of biological process;transport,cytosol;endosome;Golgi;membrane,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding,"Pf00069, Pf07714",22853,ENSG00000164715.5,LMTK2,7,,,,0,High,1
P01704,Immunoglobulin lambda variable 2-14 OS=Homo sapiens OX=9606 GN=IGLV2-14 PE=1 SV=2,0,18.36,23,2,58,1,120,12.6,6.49,22155,,2,,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity,"Pf07679, Pf07686",28815,ENSG00000211666.2,IGLV2-14,22,,,FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis,26,High,1
Q14978,Nucleolar and coiled-body phosphoprotein 1 OS=Homo sapiens OX=9606 GN=NOLC1 PE=1 SV=2,0,18.354,6,4,26,4,699,73.6,9.47,8714,,4,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;nucleus,nucleotide binding;protein binding;RNA binding,Pf05022,9221,ENSG00000166197.16,NOLC1,10,,,,0,High,1
Q86T65,Disheveled-associated activator of morphogenesis 2 OS=Homo sapiens OX=9606 GN=DAAM2 PE=1 SV=3,0,18.333,5,4,10,2,1068,123.4,6.8,4565,,4,,cell organization and biogenesis,,protein binding,"Pf02181, Pf06367, Pf06371",23500,ENSG00000146122.16,DAAM2,6,Wnt signaling pathway,,,1,High,1
O00400,Acetyl-coenzyme A transporter 1 OS=Homo sapiens OX=9606 GN=SLC33A1 PE=1 SV=1,0,18.297,9,4,55,4,549,60.9,7.33,19394,,4,,regulation of biological process;response to stimulus;transport,endoplasmic reticulum;membrane,transporter activity,Pf13000,9197,ENSG00000169359.13,SLC33A1,3,Metabolic pathways; Glycosphingolipid biosynthesis - ganglio series,Ganglio Sphingolipid Metabolism,"Transport of vitamins, nucleosides, and related molecules; Defective SLC33A1 causes spastic paraplegia 42 (SPG42)",10,High,1
P22735,Protein-glutamine gamma-glutamyltransferase K OS=Homo sapiens OX=9606 GN=TGM1 PE=1 SV=4,0,18.292,5,3,12,3,817,89.7,6.04,5314,,3,,cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process,cytoskeleton;cytosol;membrane,catalytic activity;metal ion binding;protein binding,"Pf00868, Pf00927, Pf01841",7051,ENSG00000092295.11,TGM1,14,,,Formation of the cornified envelope,3,High,1
O75970,Multiple PDZ domain protein OS=Homo sapiens OX=9606 GN=MPDZ PE=1 SV=2,0,18.275,4,6,16,5,2070,221.5,5.06,5726,,6,,,cytoplasm;membrane,protein binding,"Pf00595, Pf09045, Pf13180",8777,ENSG00000107186.16,MPDZ,9,Tight junction,,,1,High,1
Q9BT22,Chitobiosyldiphosphodolichol beta-mannosyltransferase OS=Homo sapiens OX=9606 GN=ALG1 PE=1 SV=2,0,18.263,11,4,16,4,464,52.5,7.23,6921,,4,,metabolic process,endoplasmic reticulum;membrane,catalytic activity,"Pf00534, Pf13692",56052,ENSG00000033011.11,ALG1,16,Metabolic pathways; N-Glycan biosynthesis,,"Defective ALG1 causes ALG1-CDG (CDG-1k); Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein",10,High,1
P02753,Retinol-binding protein 4 OS=Homo sapiens OX=9606 GN=RBP4 PE=1 SV=3,0,18.262,30,4,52,4,201,23,6.07,18171,,4,,metabolic process;regulation of biological process;response to stimulus;transport,cytosol;extracellular,protein binding;transporter activity,"Pf00061, Pf08212",5950,ENSG00000138207.13,RBP4,10,,Sterol Regulatory Element-Binding Proteins (SREBP) signalling; Vitamin A and Carotenoid Metabolism,Signaling by GPCR; Retinoid cycle disease events; The canonical retinoid cycle in rods (twilight vision); Retinoid metabolism and transport; Retinoid metabolism disease events,15,High,1
Q9Y5Y7,Lymphatic vessel endothelial hyaluronic acid receptor 1 OS=Homo sapiens OX=9606 GN=LYVE1 PE=1 SV=2,0,18.26,11,4,48,4,322,35.2,8.28,23289,,4,,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,membrane,protein binding;receptor activity;signal transducer activity,Pf00193,10894,ENSG00000133800.8,LYVE1,11,,,Hyaluronan uptake and degradation,5,High,1
O15091,Mitochondrial ribonuclease P catalytic subunit OS=Homo sapiens OX=9606 GN=PRORP PE=1 SV=2,0,18.229,9,5,14,5,583,67.3,8.78,5463,,5,,metabolic process,mitochondrion;nucleus;organelle lumen,catalytic activity;protein binding,,9692,ENSG00000100890.15; ENSG00000258790.1,KIAA0391,14,,,tRNA processing in the mitochondrion; rRNA processing in the mitochondrion,5,High,1
Q56VL3,OCIA domain-containing protein 2 OS=Homo sapiens OX=9606 GN=OCIAD2 PE=1 SV=1,0,18.184,14,2,28,2,154,16.9,9.03,13403,,2,,,endosome;membrane;mitochondrion,,Pf07051,132299,ENSG00000145247.11,OCIAD2,4,,,,0,High,1
Q6ZVF9,G protein-regulated inducer of neurite outgrowth 3 OS=Homo sapiens OX=9606 GN=GPRIN3 PE=2 SV=2,0,18.151,7,4,23,4,776,82.4,7.56,8672,,4,,,,,Pf15235,285513,ENSG00000185477.4,GPRIN3,4,,,,0,High,1
O75352,Mannose-P-dolichol utilization defect 1 protein OS=Homo sapiens OX=9606 GN=MPDU1 PE=1 SV=2,0,18.145,14,3,31,3,247,26.6,8.94,15864,,3,,metabolic process;transport,membrane,protein binding,Pf04193,9526,ENSG00000129255.15,MPDU1,17,,,"Defective MPDU1 causes MPDU1-CDG (CDG-1f); Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein",8,High,1
Q16527,Cysteine and glycine-rich protein 2 OS=Homo sapiens OX=9606 GN=CSRP2 PE=1 SV=3,0,18.131,27,4,43,3,193,20.9,8.62,13545,,4,,cell differentiation;development,nucleus,metal ion binding;protein binding,Pf00412,1466,ENSG00000175183.9,CSRP2,12,,Mesodermal Commitment Pathway; H19 action Rb-E2F1 signaling and CDK-beta-catenin activity,,2,High,1
Q7Z3B1,Neuronal growth regulator 1 OS=Homo sapiens OX=9606 GN=NEGR1 PE=1 SV=3,0,18.125,12,3,7,3,354,38.7,6.21,3017,,3,,metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,protein binding,"Pf00047, Pf07679, Pf13895, Pf13927",257194,ENSG00000172260.14,NEGR1,1,Cell adhesion molecules (CAMs),,Post-translational modification: synthesis of GPI-anchored proteins,4,High,1
O95396,Adenylyltransferase and sulfurtransferase MOCS3 OS=Homo sapiens OX=9606 GN=MOCS3 PE=1 SV=1,0,18.125,13,5,11,5,460,49.6,6.21,4166,,5,,metabolic process,cytoplasm;cytosol,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00581, Pf00899, Pf05237",27304,ENSG00000124217.4,MOCS3,20,Sulfur relay system,,Molybdenum cofactor biosynthesis,5,High,1
P06310,Immunoglobulin kappa variable 2-30 OS=Homo sapiens OX=9606 GN=IGKV2-30 PE=3 SV=2,0,18.124,33,3,54,1,120,13.2,8.51,29690,,3,,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity,"Pf07679, Pf07686",28919,ENSG00000281933.1; ENSG00000243238.1,IGKV2-30,CHR_HG2290_PATCH; 2,,,FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis,26,High,1
Q9H0F6,Sharpin OS=Homo sapiens OX=9606 GN=SHARPIN PE=1 SV=1,0,18.108,7,2,10,2,387,39.9,5.8,5067,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,catalytic activity;metal ion binding;protein binding,,81858,ENSG00000179526.16,SHARPIN,8,NOD-like receptor signaling pathway,,Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; Neurexins and neuroligins,9,High,1
Q8TD16,Protein bicaudal D homolog 2 OS=Homo sapiens OX=9606 GN=BICD2 PE=1 SV=1,0,18.069,6,4,10,4,824,93.5,5.44,3766,,4,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;Golgi;membrane;nucleus,protein binding,"Pf03961, Pf04111, Pf04156, Pf05483, Pf06785, Pf09730",23299,ENSG00000185963.13,BICD2,9,,,COPI-independent Golgi-to-ER retrograde traffic,5,High,1
Q7Z3V4,Ubiquitin-protein ligase E3B OS=Homo sapiens OX=9606 GN=UBE3B PE=1 SV=3,0,18.06,5,5,16,5,1068,123,8.19,5276,,5,,metabolic process,cytoplasm,catalytic activity;protein binding,"Pf00612, Pf00632",89910,ENSG00000151148.13,UBE3B,12,Ubiquitin mediated proteolysis,,Antigen processing: Ubiquitination & Proteasome degradation,5,High,1
P29350,Tyrosine-protein phosphatase non-receptor type 6 OS=Homo sapiens OX=9606 GN=PTPN6 PE=1 SV=1,0,18.053,9,3,8,3,595,67.5,7.78,4025,,3,,cell death;cell differentiation;cell proliferation;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen,catalytic activity;protein binding;receptor activity;signal transducer activity,"Pf00017, Pf00102, Pf00782, Pf14566",5777,ENSG00000111679.16,PTPN6,12,Jak-STAT signaling pathway; T cell receptor signaling pathway; Leishmaniasis; Proteoglycans in cancer; Natural killer cell mediated cytotoxicity; B cell receptor signaling pathway; Adherens junction,Regulation of toll-like receptor signaling pathway; Prolactin Signaling Pathway; B Cell Receptor Signaling Pathway; T-Cell Receptor and Co-stimulatory Signaling; IL-3 Signaling Pathway; Kit receptor signaling pathway; T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 Signaling Pathway; Microglia Pathogen Phagocytosis Pathway; IL-4 Signaling Pathway; Interferon type I signaling pathways,PD-1 signaling; PECAM1 interactions; Signal regulatory protein family interactions; Interleukin receptor SHC signaling; Platelet sensitization by LDL; Regulation of IFNA signaling; CD22 mediated BCR regulation; Neutrophil degranulation; GPVI-mediated activation cascade; Regulation of IFNG signaling; Regulation of KIT signaling; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Growth hormone receptor signaling,51,High,1
Q9UBN7,Histone deacetylase 6 OS=Homo sapiens OX=9606 GN=HDAC6 PE=1 SV=2,0,18.042,8,6,10,6,1215,131.3,5.3,3151,0,6,1,cell growth;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane;nucleus,catalytic activity;DNA binding;metal ion binding;protein binding;transporter activity,"Pf00850, Pf02148, Pf09595",10013,ENSG00000094631.18,HDAC6,X,Viral carcinogenesis; Alcoholism,Cell Cycle; Neural Crest Differentiation; Ectoderm Differentiation,NOTCH1 Intracellular Domain Regulates Transcription; RUNX2 regulates osteoblast differentiation; Cilium Assembly; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; HSF1 activation,28,High,1
Q9NPE2,Neugrin OS=Homo sapiens OX=9606 GN=NGRN PE=1 SV=2,0,18.026,14,4,18,4,291,32.4,9.1,7158,,4,,cell differentiation;development,extracellular;nucleus,RNA binding,Pf06413,51335,ENSG00000182768.8,NGRN,15,,,,0,High,1
Q9BUN8,Derlin-1 OS=Homo sapiens OX=9606 GN=DERL1 PE=1 SV=1,0,18.018,16,4,12,4,251,28.8,9.51,5893,,4,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;endosome;membrane,catalytic activity;protein binding;receptor activity,Pf04511,79139,ENSG00000136986.9,DERL1,8,Amyotrophic lateral sclerosis (ALS); Protein processing in endoplasmic reticulum,Amyotrophic lateral sclerosis (ALS),E3 ubiquitin ligases ubiquitinate target proteins; ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; N-glycan trimming in the ER and Calnexin/Calreticulin cycle,15,High,1
Q9Y2G8,DnaJ homolog subfamily C member 16 OS=Homo sapiens OX=9606 GN=DNAJC16 PE=2 SV=3,0,18.014,6,4,9,4,782,90.5,7.12,2693,5.29,3,1,cellular homeostasis;regulation of biological process,cytosol;membrane,,"Pf00085, Pf00226",23341,ENSG00000116138.12,DNAJC16,1,,,,0,High,1
P03952,Plasma kallikrein OS=Homo sapiens OX=9606 GN=KLKB1 PE=1 SV=1,0,18.013,6,4,13,4,638,71.3,8.22,5345,2.16,4,1,cell organization and biogenesis;coagulation;defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,catalytic activity;protein binding,"Pf00024, Pf00089, Pf13365, Pf14295",3818,,KLKB1,4,Complement and coagulation cascades,Complement and Coagulation Cascades,Activation of Matrix Metalloproteinases; Intrinsic Pathway of Fibrin Clot Formation,8,High,1
Q8IVF2,Protein AHNAK2 OS=Homo sapiens OX=9606 GN=AHNAK2 PE=1 SV=2,0,17.998,4,6,19,5,5795,616.2,5.36,8618,,6,,cell organization and biogenesis,cytoplasm;cytosol;membrane;nucleus,protein binding,,113146,ENSG00000185567.6,AHNAK2,14,,,,0,High,1
P20160,Azurocidin OS=Homo sapiens OX=9606 GN=AZU1 PE=1 SV=3,0,17.991,22,3,16,3,251,26.9,9.5,8557,,3,,cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane;organelle lumen;vacuole,catalytic activity;protein binding,Pf00089,566,ENSG00000172232.9; ENSG00000278624.2,AZU1,19; CHR_HSCHR19_5_CTG2,,,Neutrophil degranulation,3,High,1
Q96HA8,Protein N-terminal glutamine amidohydrolase OS=Homo sapiens OX=9606 GN=WDYHV1 PE=1 SV=2,0,17.986,18,3,11,3,205,23.7,5.78,5214,,3,,metabolic process,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,Pf09764,55093,ENSG00000156795.6,WDYHV1,8,,,,0,High,1
P30511,"HLA class I histocompatibility antigen, alpha chain F OS=Homo sapiens OX=9606 GN=HLA-F PE=1 SV=3",0,17.951,14,3,5,3,346,39,5.57,2587,,3,,regulation of biological process;response to stimulus,cell surface;endoplasmic reticulum;membrane,protein binding,"Pf00129, Pf07654, Pf08205",3134,ENSG00000204642.13,HLA-F,6,Epstein-Barr virus infection; Viral carcinogenesis; Graft-versus-host disease; Autoimmune thyroid disease; Cell adhesion molecules (CAMs); Allograft rejection; Antigen processing and presentation; Herpes simplex infection; HTLV-I infection; Viral myocarditis; Phagosome; Type I diabetes mellitus; Endocytosis,Proteasome Degradation; Allograft Rejection,"Interferon alpha/beta signaling; ER-Phagosome pathway; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Endosomal/Vacuolar pathway; Interferon gamma signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC",27,High,1
Q8WUH2,Transforming growth factor-beta receptor-associated protein 1 OS=Homo sapiens OX=9606 GN=TGFBRAP1 PE=1 SV=1,0,17.941,6,4,9,4,860,97.1,6.55,4323,,4,,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;endosome;membrane,protein binding,"Pf00637, Pf00780, Pf10366, Pf10367",9392,ENSG00000135966.12,TGFBRAP1,2,,,,0,High,1
Q9Y487,V-type proton ATPase 116 kDa subunit a isoform 2 OS=Homo sapiens OX=9606 GN=ATP6V0A2 PE=1 SV=2,0,17.905,6,4,16,3,856,98,6.61,6066,,4,,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,endosome;membrane,catalytic activity;protein binding;transporter activity,Pf01496,23545,ENSG00000185344.13,ATP6V0A2,12,Tuberculosis; Synaptic vesicle cycle; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Phagosome; Rheumatoid arthritis; Lysosome; Collecting duct acid secretion; Metabolic pathways; Oxidative phosphorylation,,"Transferrin endocytosis and recycling; ROS, RNS production in phagocytes; Ion channel transport; Insulin receptor recycling",21,High,1
Q5T9L3,Protein wntless homolog OS=Homo sapiens OX=9606 GN=WLS PE=1 SV=2,0,17.888,7,4,5,4,541,62.2,7.36,2672,,4,,development;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;endosome;Golgi;membrane,protein binding;signal transducer activity,Pf06664,79971,ENSG00000116729.13,WLS,1,,,WNT ligand biogenesis and trafficking,3,High,1
P38435,Vitamin K-dependent gamma-carboxylase OS=Homo sapiens OX=9606 GN=GGCX PE=1 SV=2,0,17.883,6,4,17,4,758,87.5,8.02,7719,,4,,coagulation;metabolic process,endoplasmic reticulum;membrane,catalytic activity,Pf05090,2677,ENSG00000115486.11,GGCX,2,Ubiquinone and other terpenoid-quinone biosynthesis,,Gamma-carboxylation of protein precursors,6,High,1
Q15185,Prostaglandin E synthase 3 OS=Homo sapiens OX=9606 GN=PTGES3 PE=1 SV=1,0,17.876,21,3,45,3,160,18.7,4.54,24513,5.7,2,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,Pf04969,10728,ENSG00000110958.15,PTGES3,12,Arachidonic acid metabolism; Metabolic pathways,Aryl Hydrocarbon Receptor Pathway,Attenuation phase; Synthesis of Prostaglandins (PG) and Thromboxanes (TX); HSP90 chaperone cycle for steroid hormone receptors (SHR); Aryl hydrocarbon receptor signalling; HSF1 activation,18,High,1
Q8N392,Rho GTPase-activating protein 18 OS=Homo sapiens OX=9606 GN=ARHGAP18 PE=1 SV=3,0,17.871,7,5,16,5,663,74.9,6.44,6043,,5,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,enzyme regulator activity;protein binding,Pf00620,93663,ENSG00000146376.10,ARHGAP18,6,,,Rho GTPase cycle,3,High,1
O14495,Phospholipid phosphatase 3 OS=Homo sapiens OX=9606 GN=PLPP3 PE=1 SV=1,0,17.867,11,3,36,3,311,35.1,9.14,19738,,3,,cellular component movement;metabolic process;regulation of biological process;response to stimulus,Golgi;membrane,catalytic activity;protein binding,Pf01569,8613,ENSG00000162407.8,PPAP2B; PLPP3,1,Phospholipase D signaling pathway; Sphingolipid metabolism; Fat digestion and absorption; Fc gamma R-mediated phagocytosis; Choline metabolism in cancer; Glycerolipid metabolism; Ether lipid metabolism; Metabolic pathways; Glycerophospholipid metabolism,Triacylglyceride Synthesis,Sphingolipid de novo biosynthesis,14,High,1
O94989,Rho guanine nucleotide exchange factor 15 OS=Homo sapiens OX=9606 GN=ARHGEF15 PE=1 SV=4,0,17.831,6,5,23,5,841,91.9,8.25,7976,2.93,4,1,regulation of biological process,cytoplasm,enzyme regulator activity;protein binding,Pf00621,22899,ENSG00000198844.10,ARHGEF15,17,,VEGFA-VEGFR2 Signaling Pathway,G alpha (12/13) signalling events; NRAGE signals death through JNK; Signalling by NGF; Rho GTPase cycle,12,High,1
Q9NQ34,Transmembrane protein 9B OS=Homo sapiens OX=9606 GN=TMEM9B PE=1 SV=1,0,17.819,15,1,7,1,198,22.5,8.06,2468,,1,,regulation of biological process;response to stimulus,endosome;membrane;vacuole,signal transducer activity,Pf05434,56674,ENSG00000175348.10,TMEM9B,11,,,,0,High,1
A6NNL5,Uncharacterized protein C15orf61 OS=Homo sapiens OX=9606 GN=C15orf61 PE=2 SV=2,0,17.815,21,2,17,2,157,18.1,9.86,6311,,2,,,extracellular,,Pf15031,145853,ENSG00000189227.5,C15orf61,15,,,,0,High,1
Q8IXM6,Nurim OS=Homo sapiens OX=9606 GN=NRM PE=1 SV=1,0,17.814,17,4,8,4,262,29.4,8.63,4812,,4,,,membrane;nucleus,protein binding,,11270,ENSG00000228854.8; ENSG00000228867.8; ENSG00000137404.14; ENSG00000235773.8; ENSG00000236843.8; ENSG00000234809.8; ENSG00000206484.10,NRM,6; CHR_HSCHR6_MHC_APD_CTG1; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_QBL_CTG1,,,,0,High,1
Q9Y5A7,NEDD8 ultimate buster 1 OS=Homo sapiens OX=9606 GN=NUB1 PE=1 SV=2,0,17.806,7,4,14,4,615,70.5,5.96,5918,,4,,metabolic process;regulation of biological process;response to stimulus,cytosol;nucleus,protein binding,Pf00627,51667,,NUB1,7,,,Neddylation,3,High,1
Q70UQ0,Inhibitor of nuclear factor kappa-B kinase-interacting protein OS=Homo sapiens OX=9606 GN=IKBIP PE=1 SV=1,0,17.805,15,5,12,4,350,39.3,9.17,4741,,5,,response to stimulus,endoplasmic reticulum;membrane,protein binding,Pf08317,121457,ENSG00000166130.14,IKBIP,12,,,,0,High,1
Q9BTT6,Leucine-rich repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=LRRC1 PE=1 SV=1,0,17.803,7,3,16,1,524,59.2,5.02,5390,,3,,regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,protein binding,"Pf12799, Pf13855",55227,ENSG00000137269.14,LRRC1,6,,,,0,High,1
Q9HB19,Pleckstrin homology domain-containing family A member 2 OS=Homo sapiens OX=9606 GN=PLEKHA2 PE=1 SV=2,0,17.802,10,4,18,4,425,47.2,8.66,9222,,4,,metabolic process;regulation of biological process,cytoplasm;membrane;nucleus,protein binding,"Pf00169, Pf15409, Pf15413",59339,,PLEKHA2,8,,,Synthesis of PIPs at the plasma membrane,5,High,1
Q8TBC5,Zinc finger and SCAN domain-containing protein 18 OS=Homo sapiens OX=9606 GN=ZSCAN18 PE=2 SV=2,0,17.798,10,4,6,4,510,54.8,4.82,3387,,4,,metabolic process;regulation of biological process,nucleus,DNA binding;metal ion binding,"Pf00096, Pf02023",65982,ENSG00000121413.12,ZSCAN18,19,,,,0,High,1
Q6UUV7,CREB-regulated transcription coactivator 3 OS=Homo sapiens OX=9606 GN=CRTC3 PE=1 SV=2,0,17.786,10,3,6,3,619,66.9,6.84,2867,,3,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,,"Pf12884, Pf12885, Pf12886",64784,ENSG00000140577.15,CRTC3,15,HTLV-I infection,,Transcriptional activation of mitochondrial biogenesis; Circadian Clock,5,High,1
Q9Y3X0,Coiled-coil domain-containing protein 9 OS=Homo sapiens OX=9606 GN=CCDC9 PE=1 SV=1,0,17.773,9,4,8,4,531,59.7,5.4,4010,,4,,,,protein binding;RNA binding,Pf15266,26093,ENSG00000105321.12,CCDC9,19,,,,0,High,1
Q9UFG5,UPF0449 protein C19orf25 OS=Homo sapiens OX=9606 GN=C19orf25 PE=1 SV=2,0,17.771,36,2,10,2,118,12.9,5.07,4983,,2,,,,protein binding,Pf15136,148223,ENSG00000119559.15,C19orf25,19,,,,0,High,1
Q8TB45,DEP domain-containing mTOR-interacting protein OS=Homo sapiens OX=9606 GN=DEPTOR PE=1 SV=2,0,17.77,11,4,6,4,409,46.3,8.07,2855,,4,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm,protein binding,Pf00610,64798,ENSG00000155792.9,DEPTOR,8,mTOR signaling pathway,,,1,High,1
P11274,Breakpoint cluster region protein OS=Homo sapiens OX=9606 GN=BCR PE=1 SV=2,0,17.767,4,4,19,3,1271,142.7,7.03,6842,,4,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding,"Pf00168, Pf00620, Pf00621, Pf04733, Pf09036",613,ENSG00000186716.20,BCR,22,Chronic myeloid leukemia; Pathways in cancer,Imatinib and Chronic Myeloid Leukemia,Signaling by cytosolic FGFR1 fusion mutants; Rho GTPase cycle,12,High,1
P17026,Zinc finger protein 22 OS=Homo sapiens OX=9606 GN=ZNF22 PE=1 SV=3,0,17.766,11,2,11,2,224,25.9,10.04,4323,,2,,metabolic process;regulation of biological process,nucleus,DNA binding;metal ion binding,"Pf00096, Pf13465",7570,ENSG00000165512.4,ZNF22,10,,,,0,High,1
P01160,Natriuretic peptides A OS=Homo sapiens OX=9606 GN=NPPA PE=1 SV=1,0,17.764,42,3,16,3,153,16.7,7.15,5294,11.02,1,2,cell growth;metabolic process;regulation of biological process;response to stimulus,cytoplasm;extracellular;nucleus;vacuole,protein binding,Pf00212,4878,,NPPA,1,HIF-1 signaling pathway,MicroRNAs in cardiomyocyte hypertrophy; Cardiac Hypertrophic Response,YAP1- and WWTR1 (TAZ)-stimulated gene expression; Physiological factors; Amyloid fiber formation,12,High,1
Q6P9B9,Integrator complex subunit 5 OS=Homo sapiens OX=9606 GN=INTS5 PE=1 SV=1,0,17.761,6,5,17,5,1019,107.9,7.05,5993,,5,,metabolic process,cytoplasm;membrane;nucleus,protein binding,"Pf14837, Pf14838",80789,ENSG00000185085.2,INTS5,11,,,RNA polymerase II transcribes snRNA genes,3,High,1
P51688,N-sulphoglucosamine sulphohydrolase OS=Homo sapiens OX=9606 GN=SGSH PE=1 SV=1,0,17.758,15,4,24,4,502,56.7,6.95,6633,5.04,4,1,metabolic process,organelle lumen;vacuole,catalytic activity;metal ion binding,"Pf00884, Pf01663",6448,ENSG00000181523.12,SGSH,17,Glycosaminoglycan degradation; Metabolic pathways; Lysosome,,HS-GAG degradation; MPS IIIA - Sanfilippo syndrome A,13,High,1
Q96JI7,Spatacsin OS=Homo sapiens OX=9606 GN=SPG11 PE=1 SV=3,0,17.731,2,5,19,5,2443,278.7,5.97,6784,,5,,cell communication;cell growth;cell organization and biogenesis;cellular component movement;transport,cytoplasm;cytosol;membrane;nucleus,protein binding,Pf14649,80208,ENSG00000104133.14,SPG11,15,,,,0,High,1
P04062,Lysosomal acid glucosylceramidase OS=Homo sapiens OX=9606 GN=GBA PE=1 SV=3,0,17.731,15,4,9,4,536,59.7,7.61,4380,,4,,cell communication;cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,membrane;organelle lumen;vacuole,catalytic activity;protein binding,Pf02055,2629,ENSG00000177628.15,GBA,1,Lysosome; Other glycan degradation; Metabolic pathways; Sphingolipid metabolism,,Glycosphingolipid metabolism; Association of TriC/CCT with target proteins during biosynthesis,12,High,1
Q92545,Transmembrane protein 131 OS=Homo sapiens OX=9606 GN=TMEM131 PE=1 SV=3,0,17.701,4,5,19,5,1883,205,8.59,7091,,5,,,membrane,,Pf12371,23505,ENSG00000075568.16,TMEM131,2,,,,0,High,1
Q8N201,Integrator complex subunit 1 OS=Homo sapiens OX=9606 GN=INTS1 PE=1 SV=2,0,17.68,3,5,22,5,2190,244.1,6.13,8728,,5,,metabolic process,membrane;nucleus,,Pf12432,26173,ENSG00000164880.15,INTS1,7,,,RNA polymerase II transcribes snRNA genes,3,High,1
P34896,"Serine hydroxymethyltransferase, cytosolic OS=Homo sapiens OX=9606 GN=SHMT1 PE=1 SV=1",0,17.663,7,2,17,1,483,53,7.71,9116,,2,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;mitochondrion;nucleus,catalytic activity;protein binding;RNA binding;translation regulator activity,Pf00464,6470,ENSG00000176974.19,SHMT1,17,"Biosynthesis of amino acids; Glyoxylate and dicarboxylate metabolism; Glycine, serine and threonine metabolism; One carbon pool by folate; Antifolate resistance; Carbon metabolism; Metabolic pathways",Folate Metabolism; One Carbon Metabolism; Trans-sulfuration and one carbon metabolism; One carbon metabolism and related pathways,Metabolism of folate and pterines; Carnitine synthesis,18,High,1
Q9BWH6,RNA polymerase II-associated protein 1 OS=Homo sapiens OX=9606 GN=RPAP1 PE=1 SV=3,0,17.66,4,5,22,5,1393,152.7,6.38,8162,,5,,metabolic process,nucleus,catalytic activity;DNA binding;protein binding,"Pf08620, Pf08621",26015,ENSG00000103932.11,RPAP1,15,,,,0,High,1
Q6IPR1,Electron transfer flavoprotein regulatory factor 1 OS=Homo sapiens OX=9606 GN=ETFRF1 PE=1 SV=2,0,17.651,30,3,40,3,90,10.9,9.92,21978,,3,,metabolic process,mitochondrion,protein binding,"Pf05347, Pf13232, Pf13233",144363,ENSG00000205707.10,LYRM5; ETFRF1,12,,,,0,High,1
P30039,Phenazine biosynthesis-like domain-containing protein OS=Homo sapiens OX=9606 GN=PBLD PE=1 SV=2,0,17.635,20,4,10,4,288,31.8,6.52,3325,,4,,metabolic process;regulation of biological process,cytoplasm,catalytic activity;protein binding,Pf02567,64081,ENSG00000108187.15,PBLD,10,,,,0,High,1
Q14571,"Inositol 1,4,5-trisphosphate receptor type 2 OS=Homo sapiens OX=9606 GN=ITPR2 PE=1 SV=2",0,17.631,2,5,25,2,2701,307.9,6.43,9333,,5,,cellular homeostasis;regulation of biological process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;membrane;nucleus,metal ion binding;protein binding;receptor activity;signal transducer activity;transporter activity,"Pf01365, Pf02815, Pf08454, Pf08709, Pf12670",3709,ENSG00000123104.11,ITPR2,12,Dopaminergic synapse; Alzheimer's disease; Thyroid hormone synthesis; Platelet activation; Oxytocin signaling pathway; Inflammatory mediator regulation of TRP channels; Vascular smooth muscle contraction; Retrograde endocannabinoid signaling; Apoptosis; Phosphatidylinositol signaling system; Cholinergic synapse; cGMP-PKG signaling pathway; Gastric acid secretion; Serotonergic synapse; Long-term depression; Long-term potentiation; GnRH signaling pathway; Proteoglycans in cancer; Renin secretion; Salivary secretion; Pancreatic secretion; Glutamatergic synapse; Oocyte meiosis; Glucagon signaling pathway; Calcium signaling pathway; NOD-like receptor signaling pathway; Aldosterone synthesis and secretion; Gap junction; Estrogen signaling pathway,Alzheimers Disease; Myometrial Relaxation and Contraction Pathways; Calcium Regulation in the Cardiac Cell,Ion homeostasis; FCERI mediated Ca+2 mobilization; PLC beta mediated events; Ca2+ pathway; DAG and IP3 signaling; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Elevation of cytosolic Ca2+ levels; Effects of PIP2 hydrolysis; Gastrin-CREB signalling pathway via PKC and MAPK; VEGFR2 mediated cell proliferation; CLEC7A (Dectin-1) induces NFAT activation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of phospholipids in phagocytosis,74,High,1
O43272-1,"Isoform 3 of Proline dehydrogenase 1, mitochondrial OS=Homo sapiens OX=9606 GN=PRODH",0,17.629,11,3,7,3,516,59.2,6.89,2946,,3,,metabolic process;regulation of biological process;response to stimulus,membrane;mitochondrion;organelle lumen,catalytic activity;nucleotide binding,Pf01619,5625,,PRODH,22,,,,0,High,1
P62487,DNA-directed RNA polymerase II subunit RPB7 OS=Homo sapiens OX=9606 GN=POLR2G PE=1 SV=1,0,17.617,28,4,16,4,172,19.3,5.54,4382,,4,,cell death;metabolic process;regulation of biological process;response to stimulus,nucleus,catalytic activity;DNA binding;protein binding;RNA binding,"Pf00575, Pf03876",5436,ENSG00000168002.11,POLR2G,11,RNA polymerase; Pyrimidine metabolism; Huntington's disease; Metabolic pathways; Purine metabolism; Epstein-Barr virus infection,Eukaryotic Transcription Initiation,Signaling by FGFR2 IIIa TM; RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Formation of HIV-1 elongation complex containing HIV-1 Tat; MicroRNA (miRNA) biogenesis; Formation of the HIV-1 Early Elongation Complex; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; TP53 Regulates Transcription of DNA Repair Genes; Transcriptional regulation by small RNAs; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; RNA Polymerase II HIV Promoter Escape; Formation of HIV elongation complex in the absence of HIV Tat; Transcriptional regulation of pluripotent stem cells; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; Formation of TC-NER Pre-Incision Complex; Pausing and recovery of HIV elongation; RNA Polymerase II Promoter Escape; HIV elongation arrest and recovery; RNA Pol II CTD phosphorylation and interaction with CE; Viral Messenger RNA Synthesis; RNA Polymerase II Transcription Initiation; mRNA Capping; Dual incision in TC-NER; PIWI-interacting RNA (piRNA) biogenesis; Pausing and recovery of Tat-mediated HIV elongation; Formation of the Early Elongation Complex,75,High,1
Q06587,E3 ubiquitin-protein ligase RING1 OS=Homo sapiens OX=9606 GN=RING1 PE=1 SV=2,0,17.609,10,3,8,3,406,42.4,5.62,3765,,3,,cell organization and biogenesis;metabolic process;regulation of biological process,cytosol;nucleus,catalytic activity;enzyme regulator activity;metal ion binding;protein binding,"Pf00097, Pf11789, Pf13639, Pf13920, Pf13923, Pf14570, Pf14634, Pf14835, Pf15227",6015,ENSG00000226788.3; ENSG00000204227.4; ENSG00000228520.3; ENSG00000206287.5; ENSG00000231115.3; ENSG00000235107.3,RING1,6; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_MANN_CTG1,,Notch Signaling Pathway,RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; SUMOylation of chromatin organization proteins; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; SUMOylation of DNA damage response and repair proteins; Oxidative Stress Induced Senescence; SUMOylation of RNA binding proteins,23,High,1
O60706,ATP-binding cassette sub-family C member 9 OS=Homo sapiens OX=9606 GN=ABCC9 PE=1 SV=2,0,17.601,3,4,22,4,1549,174.1,7.37,3327,26.46,1,3,defense response;metabolic process;regulation of biological process;response to stimulus;transport,membrane,catalytic activity;nucleotide binding;protein binding;receptor activity;signal transducer activity;transporter activity,"Pf00005, Pf00664, Pf08477, Pf10662",10060,ENSG00000069431.11,ABCC9,12,ABC transporters,,"Ion homeostasis; Defective ABCC9 causes dilated cardiomyopathy 10, familial atrial fibrillation 12 and hypertrichotic osteochondrodysplasia; ATP sensitive Potassium channels; ABC-family proteins mediated transport",14,High,1
Q9BQ70,Transcription factor 25 OS=Homo sapiens OX=9606 GN=TCF25 PE=1 SV=1,0,17.593,9,5,10,5,676,76.6,6.35,4059,,5,,metabolic process;regulation of biological process,nucleus,DNA binding;protein binding,Pf04910,22980,ENSG00000141002.19,TCF25,16,,,,0,High,1
Q9BQC3,2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 OS=Homo sapiens OX=9606 GN=DPH2 PE=1 SV=1,0,17.588,10,3,13,3,489,52.1,5.53,5469,,3,,metabolic process,cytosol,catalytic activity;protein binding,Pf01866,1802,ENSG00000132768.13,DPH2,1,,,Synthesis of diphthamide-EEF2,4,High,1
P61009,Signal peptidase complex subunit 3 OS=Homo sapiens OX=9606 GN=SPCS3 PE=1 SV=1,0,17.582,32,4,21,4,180,20.3,8.62,9017,,4,,metabolic process;transport,endoplasmic reticulum;membrane,catalytic activity,Pf04573,60559,ENSG00000129128.12,SPCS3,4,Protein export,,"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Synthesis, secretion, and deacylation of Ghrelin; SRP-dependent cotranslational protein targeting to membrane; Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)",9,High,1
Q5SYE7,NHS-like protein 1 OS=Homo sapiens OX=9606 GN=NHSL1 PE=1 SV=2,0,17.569,3,4,11,4,1610,170.6,6.96,4785,,4,,cellular component movement,membrane,,Pf15273,57224,ENSG00000135540.11,NHSL1,6,,,,0,High,1
Q9BV10,"Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase OS=Homo sapiens OX=9606 GN=ALG12 PE=1 SV=1",0,17.561,16,4,11,4,488,54.6,9.58,4805,,4,,metabolic process,endoplasmic reticulum;membrane,catalytic activity,Pf03901,79087,ENSG00000182858.13,ALG12,22,N-Glycan biosynthesis; Metabolic pathways,,"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG12 causes ALG12-CDG (CDG-1g)",10,High,1
O75570,"Peptide chain release factor 1, mitochondrial OS=Homo sapiens OX=9606 GN=MTRF1 PE=1 SV=2",0,17.56,14,4,12,4,445,52.3,8.5,4195,,4,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;mitochondrion,RNA binding,"Pf00472, Pf03462",9617,ENSG00000120662.15,MTRF1,13,,,,0,High,1
Q6UX71,Plexin domain-containing protein 2 OS=Homo sapiens OX=9606 GN=PLXDC2 PE=1 SV=1,0,17.547,9,3,11,3,529,59.5,6.46,5570,,3,,,membrane,protein binding,Pf01437,84898,ENSG00000120594.16,PLXDC2,10,,,,0,High,1
P33402,Guanylate cyclase soluble subunit alpha-2 OS=Homo sapiens OX=9606 GN=GUCY1A2 PE=1 SV=1,0,17.508,7,4,21,4,732,81.7,7.66,7058,,4,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00211, Pf07700, Pf07701",2977,ENSG00000152402.10,GUCY1A2,11,Salivary secretion; Purine metabolism; Gap junction; cGMP-PKG signaling pathway; Oxytocin signaling pathway; Renin secretion; Platelet activation; Vascular smooth muscle contraction; Long-term depression; Circadian entrainment,,Nitric oxide stimulates guanylate cyclase,13,High,1
A0A075B6Q5,Immunoglobulin heavy variable 3-64 OS=Homo sapiens OX=9606 GN=IGHV3-64 PE=3 SV=1,0,17.479,32,4,28,2,118,12.9,7.85,10816,,4,,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,catalytic activity;protein binding,Pf03492,28414,ENSG00000223648.4; ENSG00000274236.3,LOC100291056; IGHV3-64,14; CHR_HSCHR14_3_CTG1,,,,0,High,1
P61626,Lysozyme C OS=Homo sapiens OX=9606 GN=LYZ PE=1 SV=1,0,17.477,17,3,82,3,148,16.5,9.16,38916,,3,,defense response;metabolic process;response to stimulus;transport,extracellular;organelle lumen,catalytic activity;protein binding,Pf00062,4069,ENSG00000090382.6,LYZ,12,Salivary secretion,,Antimicrobial peptides; Neutrophil degranulation; Amyloid fiber formation,7,High,1
Q6P4F2,"Ferredoxin-2, mitochondrial OS=Homo sapiens OX=9606 GN=FDX2 PE=1 SV=2",0,17.474,12,2,17,2,186,19.9,5.54,7322,,2,,,,,,,,,,,,,0,High,1
P35612,Beta-adducin OS=Homo sapiens OX=9606 GN=ADD2 PE=1 SV=3,0,17.457,10,6,16,5,726,80.8,5.92,4745,,6,,cell organization and biogenesis;cellular component movement;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;membrane,protein binding;structural molecule activity,Pf00596,119,ENSG00000075340.22,ADD2,2,,,Miscellaneous transport and binding events,2,High,1
Q8NBN3,Transmembrane protein 87A OS=Homo sapiens OX=9606 GN=TMEM87A PE=1 SV=3,0,17.428,8,3,15,3,555,63.4,6.74,4994,,3,,transport,cytosol;Golgi;membrane,,Pf06814,25963,ENSG00000103978.15,TMEM87A,15,,,,0,High,1
Q5SNT2,Transmembrane protein 201 OS=Homo sapiens OX=9606 GN=TMEM201 PE=1 SV=1,0,17.427,6,4,20,4,666,72.2,9.22,9347,,4,,cell organization and biogenesis;cellular component movement,cytoplasm;cytoskeleton;membrane;nucleus,protein binding,"Pf09779, Pf10476",199953,ENSG00000188807.12,TMEM201,1,,,,0,High,1
Q9Y4D8,Probable E3 ubiquitin-protein ligase HECTD4 OS=Homo sapiens OX=9606 GN=HECTD4 PE=1 SV=5,0,17.422,2,6,34,6,3996,439.1,6.19,9913,,6,,metabolic process,cytoplasm;membrane,catalytic activity;protein binding,"Pf00622, Pf00632",283450,,HECTD4,12,,,,0,High,1
P62318,Small nuclear ribonucleoprotein Sm D3 OS=Homo sapiens OX=9606 GN=SNRPD3 PE=1 SV=1,0,17.403,15,2,68,2,126,13.9,10.32,37358,,2,,cell organization and biogenesis;metabolic process;transport,cytoplasm;cytosol;nucleus;spliceosomal complex,protein binding;RNA binding,Pf01423,6634,ENSG00000100028.11,SNRPD3,22,Systemic lupus erythematosus; Spliceosome,mRNA Processing,SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; snRNP Assembly; Cleavage of Growing Transcript in the Termination Region,17,High,1
Q8NEB9,Phosphatidylinositol 3-kinase catalytic subunit type 3 OS=Homo sapiens OX=9606 GN=PIK3C3 PE=1 SV=1,0,17.39,7,5,14,5,887,101.5,6.81,4395,,5,,cell communication;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;endosome;membrane;vacuole,catalytic activity;nucleotide binding;protein binding,"Pf00454, Pf00613, Pf00792",5289,ENSG00000078142.12,PIK3C3,18,Phagosome; Metabolic pathways; Tuberculosis; Autophagy; Inositol phosphate metabolism; Phosphatidylinositol signaling system,AMP-activated Protein Kinase (AMPK) Signaling; Angiopoietin Like Protein 8 Regulatory Pathway; Microglia Pathogen Phagocytosis Pathway; Insulin Signaling; Regulation of Actin Cytoskeleton; Senescence and Autophagy in Cancer; DNA Damage Response (only ATM dependent),PI3K Cascade; Toll Like Receptor 9 (TLR9) Cascade; Interleukin-7 signaling; RHO GTPases Activate NADPH Oxidases; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; Macroautophagy,41,High,1
Q9UBF8,Phosphatidylinositol 4-kinase beta OS=Homo sapiens OX=9606 GN=PI4KB PE=1 SV=1,0,17.368,4,3,10,3,816,91.3,6.25,4379,,3,,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;endosome;Golgi;membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding,Pf00454,5298,ENSG00000143393.16,PI4KB,1,Phosphatidylinositol signaling system; Inositol phosphate metabolism; Metabolic pathways,,Synthesis of PIPs at the Golgi membrane,8,High,1
Q9BVL2,Nucleoporin p58/p45 OS=Homo sapiens OX=9606 GN=NUP58 PE=1 SV=1,0,17.361,8,3,10,3,599,60.9,9.33,3771,,3,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,membrane;nucleus,protein binding;structural molecule activity;transporter activity,,9818,ENSG00000139496.15,NUPL1; NUP58,13,RNA transport,,Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins,64,High,1
Q9HBH1,"Peptide deformylase, mitochondrial OS=Homo sapiens OX=9606 GN=PDF PE=1 SV=1",0,17.351,18,3,25,3,243,27,9.16,11359,,3,,metabolic process;regulation of biological process,mitochondrion,catalytic activity;metal ion binding,Pf01327,64146,ENSG00000258429.1,PDF,16,,,,0,High,1
Q9NPR2,Semaphorin-4B OS=Homo sapiens OX=9606 GN=SEMA4B PE=1 SV=4,0,17.351,8,4,14,4,837,92.7,7.05,5288,,4,,,,,,,,,,,,,0,High,1
Q9Y5A9,YTH domain-containing family protein 2 OS=Homo sapiens OX=9606 GN=YTHDF2 PE=1 SV=2,0,17.339,6,3,21,1,579,62.3,8.79,8368,,3,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,protein binding;RNA binding,Pf04146,51441,ENSG00000198492.15,YTHDF2,1,,,,0,High,1
O15235,"28S ribosomal protein S12, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS12 PE=1 SV=1",0,17.321,14,2,68,2,138,15.2,10.29,29394,,2,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,protein binding;RNA binding;structural molecule activity,Pf00164,6183,ENSG00000283018.1; ENSG00000128626.11,MRPS12,19; CHR_HG26_PATCH,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
Q9NW81,Distal membrane-arm assembly complex protein 2 OS=Homo sapiens OX=9606 GN=DMAC2 PE=1 SV=3,0,17.294,14,3,20,2,257,29.2,6.43,7830,,3,,cell organization and biogenesis,mitochondrion,,,55101,ENSG00000105341.18,ATP5SL; DMAC2,19,,,,0,High,1
Q12974,Protein tyrosine phosphatase type IVA 2 OS=Homo sapiens OX=9606 GN=PTP4A2 PE=1 SV=1,0,17.294,14,2,34,2,167,19.1,8.37,12646,,2,,metabolic process,cytoplasm;cytosol;endosome;membrane;nucleus,catalytic activity,"Pf00102, Pf00782",8073,ENSG00000184007.18,PTP4A2,1,,,RAB geranylgeranylation,3,High,1
Q13542,Eukaryotic translation initiation factor 4E-binding protein 2 OS=Homo sapiens OX=9606 GN=EIF4EBP2 PE=1 SV=1,0,17.286,38,3,12,3,120,12.9,6.67,3457,,3,,metabolic process;regulation of biological process;response to stimulus,cytoplasm,protein binding;RNA binding;translation regulator activity,Pf05456,1979,ENSG00000148730.6,EIF4EBP2,10,Longevity regulating pathway - multiple species; RNA transport,Translation Factors,,3,High,1
O43709,Probable 18S rRNA (guanine-N(7))-methyltransferase OS=Homo sapiens OX=9606 GN=BUD23 PE=1 SV=2,0,17.273,15,3,11,2,281,31.9,8.73,5241,,3,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;nucleus,catalytic activity;protein binding;RNA binding,"Pf01209, Pf08241, Pf08242, Pf12589, Pf12847, Pf13489, Pf13649, Pf13659, Pf13847",114049,ENSG00000071462.11,WBSCR22; BUD23,7,,,Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol,5,High,1
Q02318,"Sterol 26-hydroxylase, mitochondrial OS=Homo sapiens OX=9606 GN=CYP27A1 PE=1 SV=1",0,17.265,11,6,24,6,531,60.2,8.9,8458,,6,,metabolic process,membrane;mitochondrion;organelle lumen,catalytic activity;metal ion binding,Pf00067,1593,ENSG00000135929.8,CYP27A1,2,Metabolic pathways; Primary bile acid biosynthesis; PPAR signaling pathway,Vitamin D Metabolism; PPAR signaling pathway; Oxidation by Cytochrome P450; Metapathway biotransformation,Endogenous sterols; Synthesis of bile acids and bile salts via 27-hydroxycholesterol; Synthesis of bile acids and bile salts via 24-hydroxycholesterol; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX),23,High,1
Q9HCS7,Pre-mRNA-splicing factor SYF1 OS=Homo sapiens OX=9606 GN=XAB2 PE=1 SV=2,0,17.26,7,5,13,5,855,99.9,6.23,4327,,5,,cell organization and biogenesis;metabolic process;response to stimulus,membrane;nucleus;spliceosomal complex,protein binding,Pf13424,56949,ENSG00000076924.11,XAB2,19,Spliceosome,,Dual incision in TC-NER; Formation of TC-NER Pre-Incision Complex; mRNA Splicing - Major Pathway; Gap-filling DNA repair synthesis and ligation in TC-NER,11,High,1
A4D126,D-ribitol-5-phosphate cytidylyltransferase OS=Homo sapiens OX=9606 GN=CRPPA PE=1 SV=2,0,17.256,10,3,9,3,451,49.8,6.25,3503,,3,,cellular component movement;metabolic process,cytoplasm;cytosol,catalytic activity;protein binding,"Pf01128, Pf12804",729920,ENSG00000214960.9,ISPD,7,,,,0,High,1
P56962,Syntaxin-17 OS=Homo sapiens OX=9606 GN=STX17 PE=1 SV=2,0,17.252,16,3,12,3,302,33.4,6.57,3527,,3,,cell organization and biogenesis;metabolic process;transport,cytoplasm;cytosol;endoplasmic reticulum;membrane;mitochondrion;vacuole,protein binding,Pf05739,55014,ENSG00000136874.10,STX17,9,SNARE interactions in vesicular transport,,COPII (Coat Protein 2) Mediated Vesicle Transport,9,High,1
Q9UKN8,General transcription factor 3C polypeptide 4 OS=Homo sapiens OX=9606 GN=GTF3C4 PE=1 SV=2,0,17.252,9,5,101,5,822,91.9,6.65,42227,,5,,cell organization and biogenesis;metabolic process;regulation of biological process,mitochondrion;nucleus,catalytic activity;DNA binding;enzyme regulator activity;protein binding,"Pf12657, Pf12660",9329,ENSG00000125484.11,GTF3C4,9,,,RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter,6,High,1
O15121,Sphingolipid delta(4)-desaturase DES1 OS=Homo sapiens OX=9606 GN=DEGS1 PE=1 SV=1,0,17.235,15,3,10,3,323,37.8,7.46,3538,,3,,metabolic process;transport,endoplasmic reticulum;membrane;mitochondrion,catalytic activity,"Pf00487, Pf08557",8560,ENSG00000143753.12,DEGS1,1,Sphingolipid signaling pathway; Sphingolipid metabolism; Metabolic pathways,,Neutrophil degranulation; Sphingolipid de novo biosynthesis,10,High,1
O00478,Butyrophilin subfamily 3 member A3 OS=Homo sapiens OX=9606 GN=BTN3A3 PE=1 SV=1,0,17.232,10,4,18,4,584,65,5.53,7589,,4,,response to stimulus,membrane,protein binding,"Pf00622, Pf07679, Pf13765",10384,ENSG00000111801.15,BTN3A3,6,,,Butyrophilin (BTN) family interactions,3,High,1
Q6KB66,"Keratin, type II cytoskeletal 80 OS=Homo sapiens OX=9606 GN=KRT80 PE=1 SV=2",0,17.192,11,3,10,3,452,50.5,5.67,4444,,3,,cell death;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol,protein binding;structural molecule activity;transporter activity,"Pf00038, Pf01496, Pf05557, Pf12128, Pf13166",144501,ENSG00000167767.13,KRT80,12,,,Formation of the cornified envelope,3,High,1
P57768,Sorting nexin-16 OS=Homo sapiens OX=9606 GN=SNX16 PE=1 SV=2,0,17.19,15,4,9,4,344,39.1,4.65,4370,,4,,transport,cytoplasm;cytosol;endosome;membrane;vacuole,protein binding,Pf00787,64089,ENSG00000104497.13,SNX16,8,,,,0,High,1
P08243,Asparagine synthetase [glutamine-hydrolyzing] OS=Homo sapiens OX=9606 GN=ASNS PE=1 SV=4,0,17.139,6,3,20,3,561,64.3,6.86,9256,,3,,cell communication;metabolic process;regulation of biological process;response to stimulus,cytosol,catalytic activity;nucleotide binding;protein binding,"Pf00310, Pf00733, Pf12481, Pf13522, Pf13537",440,ENSG00000070669.16,ASNS,7,"Alanine, aspartate and glutamate metabolism; Metabolic pathways",Photodynamic therapy-induced unfolded protein response; Amino Acid metabolism,Amino acid synthesis and interconversion (transamination); ATF4 activates genes,11,High,1
Q9HCD5,Nuclear receptor coactivator 5 OS=Homo sapiens OX=9606 GN=NCOA5 PE=1 SV=2,0,17.139,8,3,12,3,579,65.5,9.6,4866,,3,,metabolic process;regulation of biological process,cytoskeleton;nucleus,protein binding;RNA binding,,57727,ENSG00000124160.11,NCOA5,20,,,,0,High,1
Q9NU22,Midasin OS=Homo sapiens OX=9606 GN=MDN1 PE=1 SV=2,0,17.131,1,5,13,5,5596,632.4,5.68,4397,,5,,cell organization and biogenesis;metabolic process,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00004, Pf00092, Pf02367, Pf07726, Pf07728, Pf13401, Pf13671",23195,ENSG00000112159.11,MDN1,6,Ribosome biogenesis in eukaryotes,,,1,High,1
Q9H3S4,Thiamin pyrophosphokinase 1 OS=Homo sapiens OX=9606 GN=TPK1 PE=1 SV=1,0,17.122,16,2,9,2,243,27.2,5.2,4528,,2,,metabolic process,cytosol,catalytic activity;nucleotide binding,"Pf04263, Pf04265",27010,ENSG00000196511.14,TPK1,7,Thiamine metabolism; Metabolic pathways,,Vitamin B1 (thiamin) metabolism,6,High,1
Q6ZUT6,Coiled-coil domain-containing protein 9B OS=Homo sapiens OX=9606 GN=CCDC9B PE=1 SV=1,0,17.119,16,5,10,5,534,57.3,9.13,4125,,5,,,,RNA binding,Pf15266,388115,ENSG00000188549.12,C15orf52; CCDC9B,15,,,,0,High,1
P00533,Epidermal growth factor receptor OS=Homo sapiens OX=9606 GN=EGFR PE=1 SV=2,0,17.112,7,5,15,4,1210,134.2,6.68,4750,,5,,cell organization and biogenesis;cell proliferation;cellular component movement;development;metabolic process;regulation of biological process;response to stimulus,cell surface;cytoplasm;endoplasmic reticulum;endosome;extracellular;Golgi;membrane;nucleus;organelle lumen,catalytic activity;DNA binding;enzyme regulator activity;nucleotide binding;protein binding;receptor activity;signal transducer activity,"Pf00069, Pf00757, Pf01030, Pf07714, Pf14843",1956,ENSG00000146648.17,EGFR,7,ErbB signaling pathway; GnRH signaling pathway; Non-small cell lung cancer; Regulation of actin cytoskeleton; MicroRNAs in cancer; Focal adhesion; Dorso-ventral axis formation; Prostate cancer; Estrogen signaling pathway; Endometrial cancer; Ras signaling pathway; Cytokine-cytokine receptor interaction; Choline metabolism in cancer; Pancreatic cancer; Melanoma; MAPK signaling pathway; Bladder cancer; HIF-1 signaling pathway; Glioma; Calcium signaling pathway; Rap1 signaling pathway; Adherens junction; Endocytosis; Pathways in cancer; Epithelial cell signaling in Helicobacter pylori infection; Phospholipase D signaling pathway; Proteoglycans in cancer; Breast cancer; Endocrine resistance; FoxO signaling pathway; EGFR tyrosine kinase inhibitor resistance; Oxytocin signaling pathway; Hepatitis C; Central carbon metabolism in cancer; Gap junction; PI3K-Akt signaling pathway,Androgen receptor signaling pathway; Signaling Pathways in Glioblastoma; AGE/RAGE pathway; Gastric cancer network 2; Spinal Cord Injury; Aryl Hydrocarbon Receptor; Bladder Cancer; TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer; Extracellular vesicle-mediated signaling in recipient cells; Aryl Hydrocarbon Receptor Pathway; Focal Adhesion; Rac1/Pak1/p38/MMP-2 pathway; Association Between Physico-Chemical Features and Toxicity Associated Pathways; MAPK Signaling Pathway; ERK Pathway in Huntington's Disease; BMP Signaling Pathway in Eyelid Development; ESC Pluripotency Pathways; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; EGF/EGFR Signaling Pathway; Regulation of Actin Cytoskeleton; ErbB Signaling Pathway,"EGFR interacts with phospholipase C-gamma; TFAP2 (AP-2) family regulates transcription of growth factors and their receptors; SHC1 events in ERBB2 signaling; EGFR downregulation; Signaling by GPCR; ERBB2 Regulates Cell Motility; GRB2 events in EGFR signaling; EGFR Transactivation by Gastrin; ERBB2 Activates PTK6 Signaling; Constitutive Signaling by Aberrant PI3K in Cancer; Interleukin-20 family signaling; Cargo recognition for clathrin-mediated endocytosis; Downregulation of ERBB2 signaling; Signal transduction by L1; Signaling by ERBB4; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; SHC1 events in EGFR signaling; Constitutive Signaling by EGFRvIII; PTK6 promotes HIF1A stabilization; PLCG1 events in ERBB2 signaling; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; GRB2 events in ERBB2 signaling; GAB1 signalosome; PI3K events in ERBB2 signaling; RAF/MAP kinase cascade; Inhibition of Signaling by Overexpressed EGFR",115,High,1
Q01629,Interferon-induced transmembrane protein 2 OS=Homo sapiens OX=9606 GN=IFITM2 PE=1 SV=2,0,17.088,31,2,7,1,132,14.6,7.42,4920,,2,,defense response;regulation of biological process;response to stimulus,membrane,,Pf04505,10581,ENSG00000185201.16,IFITM2,11,,,Interferon alpha/beta signaling,4,High,1
Q14671,Pumilio homolog 1 OS=Homo sapiens OX=9606 GN=PUM1 PE=1 SV=3,0,17.088,5,4,7,4,1186,126.4,6.84,2403,,4,,cell differentiation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,protein binding;RNA binding,Pf00806,9698,ENSG00000134644.15,PUM1,1,,,Golgi Associated Vesicle Biogenesis,5,High,1
Q9GZN8,UPF0687 protein C20orf27 OS=Homo sapiens OX=9606 GN=C20orf27 PE=1 SV=3,0,17.086,19,2,24,2,174,19.3,6.84,8158,,2,,,,,Pf15006,54976,ENSG00000101220.17,C20orf27,20,,,,0,High,1
Q96K19,E3 ubiquitin-protein ligase RNF170 OS=Homo sapiens OX=9606 GN=RNF170 PE=1 SV=2,0,17.053,15,3,10,3,258,29.8,5.58,4598,,3,,metabolic process,endoplasmic reticulum;membrane,catalytic activity;metal ion binding;protein binding,"Pf00097, Pf13445, Pf13639, Pf13920, Pf13923, Pf14634, Pf15227, Pf15616",81790,ENSG00000120925.15,RNF170,8,,,,0,High,1
P50452,Serpin B8 OS=Homo sapiens OX=9606 GN=SERPINB8 PE=1 SV=2,0,17.043,7,3,93,1,374,42.7,5.57,47780,,3,,regulation of biological process,cytoplasm;cytosol,enzyme regulator activity;protein binding,Pf00079,5271,ENSG00000166401.14,SERPINB8,18,,,Dissolution of Fibrin Clot,2,High,1
P60602,Reactive oxygen species modulator 1 OS=Homo sapiens OX=9606 GN=ROMO1 PE=1 SV=1,0,17.004,35,3,37,3,79,8.2,9.33,16768,0,3,1,defense response;regulation of biological process;response to stimulus,membrane;mitochondrion,,Pf10247,140823,ENSG00000125995.15,ROMO1,20,,,,0,High,1
Q8NBZ7,UDP-glucuronic acid decarboxylase 1 OS=Homo sapiens OX=9606 GN=UXS1 PE=1 SV=1,0,17.004,14,4,9,4,420,47.5,8.94,4334,,4,,cell organization and biogenesis;metabolic process,cytoplasm;Golgi;membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding,"Pf01073, Pf01370, Pf02441, Pf02719, Pf04321, Pf07993, Pf11803, Pf13460",80146,ENSG00000115652.14,UXS1,2,Metabolic pathways; Amino sugar and nucleotide sugar metabolism,,,2,High,1
P24941,Cyclin-dependent kinase 2 OS=Homo sapiens OX=9606 GN=CDK2 PE=1 SV=2,0,16.988,17,4,18,2,298,33.9,8.68,5389,,4,,cell division;cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus;transport,chromosome;cytoplasm;cytoskeleton;cytosol;endosome;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf07714, Pf14531",1017,ENSG00000123374.10,CDK2,12,p53 signaling pathway; Progesterone-mediated oocyte maturation; Hepatitis B; Cell cycle; Measles; Prostate cancer; Epstein-Barr virus infection; PI3K-Akt signaling pathway; Viral carcinogenesis; Small cell lung cancer; Herpes simplex infection; Oocyte meiosis; Pathways in cancer; FoxO signaling pathway,miRNA Regulation of DNA Damage Response; Cell Cycle; Human Thyroid Stimulating Hormone (TSH) signaling pathway; Signaling Pathways in Glioblastoma; Oncostatin M Signaling Pathway; Spinal Cord Injury; Retinoblastoma (RB) in Cancer; Aryl Hydrocarbon Receptor; G1 to S cell cycle control; DNA Replication; ID signaling pathway; DNA Damage Response,p53-Dependent G1 DNA Damage Response; G0 and Early G1; Regulation of DNA replication; Activation of the pre-replicative complex; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; SCF(Skp2)-mediated degradation of p27/p21; Factors involved in megakaryocyte development and platelet production; G2 Phase; Meiotic recombination; Regulation of APC/C activators between G1/S and early anaphase; PTK6 Regulates Cell Cycle; Regulation of TP53 Activity through Phosphorylation; Regulation of TP53 Degradation; CDK-mediated phosphorylation and removal of Cdc6; Orc1 removal from chromatin; Cyclin A/B1/B2 associated events during G2/M transition; M/G1 Transition; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; DNA Damage/Telomere Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Removal of licensing factors from origins,88,High,1
O43157,Plexin-B1 OS=Homo sapiens OX=9606 GN=PLXNB1 PE=1 SV=3,0,16.972,4,5,6,5,2135,232.2,5.49,2233,,5,,cell growth;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,extracellular;membrane,enzyme regulator activity;protein binding;receptor activity;signal transducer activity,"Pf01403, Pf01437, Pf01833, Pf08337",5364,ENSG00000164050.12,PLXNB1,3,Axon guidance,,Sema4D mediated inhibition of cell attachment and migration; G alpha (12/13) signalling events; Sema4D induced cell migration and growth-cone collapse,11,High,1
Q86VM9,Zinc finger CCCH domain-containing protein 18 OS=Homo sapiens OX=9606 GN=ZC3H18 PE=1 SV=2,0,16.962,6,4,30,4,953,106.3,8.32,11163,,4,,,nucleus,metal ion binding;protein binding;RNA binding,Pf00642,124245,ENSG00000158545.15,ZC3H18,16,,,,0,High,1
Q9NV35,Nucleotide triphosphate diphosphatase NUDT15 OS=Homo sapiens OX=9606 GN=NUDT15 PE=1 SV=1,0,16.961,26,3,11,3,164,18.6,6.14,4326,,3,,cell communication;metabolic process;regulation of biological process;response to stimulus,cytosol,catalytic activity;metal ion binding;protein binding,Pf00293,55270,ENSG00000136159.3,NUDT15,13,,,Phosphate bond hydrolysis by NUDT proteins,5,High,1
Q9HD47,Ran guanine nucleotide release factor OS=Homo sapiens OX=9606 GN=RANGRF PE=1 SV=1,0,16.948,15,2,7,2,186,20.4,4.94,3464,,2,,regulation of biological process;transport,cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus,protein binding;transporter activity,Pf04603,29098,ENSG00000108961.13,RANGRF,17,,,Phase 0 - rapid depolarisation,3,High,1
Q15024,Exosome complex component RRP42 OS=Homo sapiens OX=9606 GN=EXOSC7 PE=1 SV=3,0,16.943,18,4,11,4,291,31.8,5.19,4362,,4,,metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;protein binding;RNA binding,"Pf01138, Pf03725",23016,ENSG00000075914.12,EXOSC7,3,RNA degradation,,"Major pathway of rRNA processing in the nucleolus and cytosol; mRNA decay by 3' to 5' exoribonuclease; ATF4 activates genes; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; KSRP (KHSRP) binds and destabilizes mRNA",15,High,1
Q08722,Leukocyte surface antigen CD47 OS=Homo sapiens OX=9606 GN=CD47 PE=1 SV=1,0,16.935,9,3,40,3,323,35.2,7.21,18477,0,3,1,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport,membrane,protein binding;receptor activity;signal transducer activity,"Pf04549, Pf08204",961,ENSG00000196776.14,CD47,3,ECM-receptor interaction,Spinal Cord Injury,Integrin cell surface interactions; Neutrophil degranulation; Cell surface interactions at the vascular wall; Signal regulatory protein family interactions,11,High,1
Q7RTV5,Peroxiredoxin-like 2C OS=Homo sapiens OX=9606 GN=PRXL2C PE=2 SV=1,0,16.919,39,4,9,4,226,24.8,8.91,3432,,4,,metabolic process,,antioxidant activity;catalytic activity,Pf13911,195827,ENSG00000158122.11,AAED1,9,,,,0,High,1
A0A0C4DH31,Immunoglobulin heavy variable 1-18 OS=Homo sapiens OX=9606 GN=IGHV1-18 PE=3 SV=1,0,16.877,38,3,6,2,117,12.8,8.84,3436,,3,,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,protein binding,,28468,ENSG00000211945.2; ENSG00000282716.1,IGHV1-18,14; CHR_HSCHR14_3_CTG1,,,,0,High,1
Q9H9A5,CCR4-NOT transcription complex subunit 10 OS=Homo sapiens OX=9606 GN=CNOT10 PE=1 SV=1,0,16.875,9,5,12,5,744,82.3,7.78,3949,,5,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,protein binding,Pf10046,25904,ENSG00000182973.18,CNOT10,3,RNA degradation,,TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Deadenylation of mRNA,10,High,1
Q92934,Bcl2-associated agonist of cell death OS=Homo sapiens OX=9606 GN=BAD PE=1 SV=3,0,16.872,46,4,14,4,168,18.4,7.15,4793,,4,,cell death;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;mitochondrion,enzyme regulator activity;protein binding,Pf10514,572,ENSG00000002330.13,BAD,11,Platinum drug resistance; Acute myeloid leukemia; Toxoplasmosis; Chronic myeloid leukemia; Tuberculosis; Endocrine resistance; Insulin signaling pathway; Pathways in cancer; Amyotrophic lateral sclerosis (ALS); Endometrial cancer; Apoptosis; PI3K-Akt signaling pathway; VEGF signaling pathway; Melanoma; cGMP-PKG signaling pathway; Prostate cancer; Ras signaling pathway; Hepatitis B; Colorectal cancer; Alzheimer's disease; cAMP signaling pathway; Hepatitis C; Focal adhesion; EGFR tyrosine kinase inhibitor resistance; Thyroid hormone signaling pathway; ErbB signaling pathway; Non-small cell lung cancer; Neurotrophin signaling pathway; Pancreatic cancer; Viral carcinogenesis,Leptin signaling pathway; IL-7 Signaling Pathway; Alzheimers Disease; TNF alpha Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Amyotrophic lateral sclerosis (ALS); Apoptosis; IL-3 Signaling Pathway; Kit receptor signaling pathway; Focal Adhesion; Rac1/Pak1/p38/MMP-2 pathway; IL-6 signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Oxidative Damage; IL-4 Signaling Pathway; ErbB Signaling Pathway; DNA Damage Response (only ATM dependent),AKT phosphorylates targets in the cytosol; NRAGE signals death through JNK; Activation of BAD and translocation to mitochondria ; Signalling by NGF; Constitutive Signaling by AKT1 E17K in Cancer; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members,67,High,1
Q9NXF1,Testis-expressed protein 10 OS=Homo sapiens OX=9606 GN=TEX10 PE=1 SV=2,0,16.832,4,3,99,3,929,105.6,9.36,35735,,3,,metabolic process,cytoplasm;nucleus,protein binding,Pf12333,54881,ENSG00000136891.13,TEX10,9,,,Major pathway of rRNA processing in the nucleolus and cytosol,4,High,1
Q9H6U6,Breast carcinoma-amplified sequence 3 OS=Homo sapiens OX=9606 GN=BCAS3 PE=1 SV=3,0,16.82,5,4,15,4,928,101.2,6.7,5230,,4,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;nucleus,enzyme regulator activity;protein binding,Pf12490,54828,ENSG00000141376.22,BCAS3,17,,Ectoderm Differentiation,,1,High,1
Q0VGL1,Ragulator complex protein LAMTOR4 OS=Homo sapiens OX=9606 GN=LAMTOR4 PE=1 SV=1,0,16.816,35,3,36,3,99,10.7,6.54,16107,,3,,cell organization and biogenesis;regulation of biological process;response to stimulus,membrane;vacuole,protein binding;structural molecule activity,,389541,ENSG00000188186.10,LAMTOR4,7,mTOR signaling pathway,,Energy dependent regulation of mTOR by LKB1-AMPK; Regulation of PTEN gene transcription; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Macroautophagy,16,High,1
P27701,CD82 antigen OS=Homo sapiens OX=9606 GN=CD82 PE=1 SV=1,0,16.815,14,3,12,3,267,29.6,5.24,7132,,3,,regulation of biological process;response to stimulus,membrane,protein binding,Pf00335,3732,ENSG00000085117.11,CD82,11,p53 signaling pathway,,,1,High,1
Q9H089,Large subunit GTPase 1 homolog OS=Homo sapiens OX=9606 GN=LSG1 PE=1 SV=2,0,16.813,6,4,6,4,658,75.2,6.38,2488,,4,,transport,cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus,catalytic activity;nucleotide binding,"Pf01926, Pf02421, Pf04548",55341,ENSG00000041802.10,LSG1,3,Ribosome biogenesis in eukaryotes,,,1,High,1
O43414,ERI1 exoribonuclease 3 OS=Homo sapiens OX=9606 GN=ERI3 PE=1 SV=2,0,16.781,12,5,29,5,337,37.2,8.07,9424,,5,,metabolic process,,catalytic activity;metal ion binding;RNA binding,Pf00929,79033,ENSG00000117419.14,ERI3,1,,,,0,High,1
Q5K651,Sterile alpha motif domain-containing protein 9 OS=Homo sapiens OX=9606 GN=SAMD9 PE=1 SV=1,0,16.779,3,4,39,4,1589,184.2,7.83,16264,,4,,cell organization and biogenesis,cytoplasm;cytosol;endosome,nucleotide binding;protein binding,"Pf00536, Pf04326, Pf07647",54809,ENSG00000205413.7,SAMD9,7,,,,0,High,1
Q8IZA0,Dyslexia-associated protein KIAA0319-like protein OS=Homo sapiens OX=9606 GN=KIAA0319L PE=1 SV=2,0,16.77,5,5,18,5,1049,115.6,6.05,5413,0,5,1,,Golgi;membrane,protein binding,Pf02010,79932,ENSG00000142687.17,KIAA0319L,1,,,,0,High,1
O43823,A-kinase anchor protein 8 OS=Homo sapiens OX=9606 GN=AKAP8 PE=1 SV=1,0,16.765,7,4,9,4,692,76.1,5.15,3717,,4,,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,chromosome;cytoplasm;Golgi;membrane;mitochondrion;nucleus,DNA binding;metal ion binding;protein binding;RNA binding,Pf04988,10270,ENSG00000105127.8,AKAP8,19,,G Protein Signaling Pathways,,1,High,1
Q8N6T3,ADP-ribosylation factor GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=ARFGAP1 PE=1 SV=2,0,16.757,17,4,9,4,406,44.6,5.66,3255,,4,,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;Golgi;membrane,catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding;RNA binding;signal transducer activity,Pf01412,55738,ENSG00000101199.12,ARFGAP1,20,Endocytosis,,COPI-dependent Golgi-to-ER retrograde traffic; Clathrin-mediated endocytosis; COPI-mediated anterograde transport; XBP1(S) activates chaperone genes,16,High,1
P84090,Enhancer of rudimentary homolog OS=Homo sapiens OX=9606 GN=ERH PE=1 SV=1,0,16.736,21,2,64,2,104,12.3,5.92,36106,,2,,metabolic process;regulation of biological process,,DNA binding;nucleotide binding;protein binding;RNA binding,Pf01133,2079,ENSG00000100632.10,ERH,14,,,,0,High,1
O00584,Ribonuclease T2 OS=Homo sapiens OX=9606 GN=RNASET2 PE=1 SV=2,0,16.685,20,4,8,4,256,29.5,7.08,3435,,4,,metabolic process;transport,endoplasmic reticulum;extracellular;organelle lumen;vacuole,catalytic activity;RNA binding,Pf00445,8635,ENSG00000026297.15,RNASET2,6,,,Neutrophil degranulation,3,High,1
Q9NZH0,G-protein coupled receptor family C group 5 member B OS=Homo sapiens OX=9606 GN=GPRC5B PE=2 SV=2,0,16.68,13,3,17,3,403,44.8,8.24,7138,,3,,regulation of biological process;response to stimulus,cell surface;cytosol;membrane;nucleus,enzyme regulator activity;protein binding;receptor activity;signal transducer activity,Pf00003,51704,ENSG00000167191.11,GPRC5B,16,,"GPCRs, Class C Metabotropic glutamate, pheromone",,1,High,1
Q8NHG8,E3 ubiquitin-protein ligase ZNRF2 OS=Homo sapiens OX=9606 GN=ZNRF2 PE=1 SV=1,0,16.671,21,2,4,2,242,24.1,7.09,2047,,2,,metabolic process,cytoplasm;cytosol;endosome;membrane;vacuole,catalytic activity;metal ion binding;protein binding,"Pf00097, Pf12678, Pf13639, Pf13923",223082,ENSG00000180233.10,ZNRF2,7,,,Antigen processing: Ubiquitination & Proteasome degradation,4,High,1
O75400,Pre-mRNA-processing factor 40 homolog A OS=Homo sapiens OX=9606 GN=PRPF40A PE=1 SV=2,0,16.658,4,3,13,3,957,108.7,7.56,5149,,3,,cell division;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process,cytosol;membrane;nucleus;spliceosomal complex,protein binding;RNA binding,"Pf00397, Pf01846",55660,,PRPF40A,2,Spliceosome,mRNA Processing,mRNA Splicing - Major Pathway,6,High,1
Q96SZ6,CDK5 regulatory subunit-associated protein 1 OS=Homo sapiens OX=9606 GN=CDK5RAP1 PE=1 SV=2,0,16.65,6,3,13,3,601,67.6,8.21,5089,,3,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;mitochondrion,catalytic activity;metal ion binding;protein binding,"Pf00919, Pf01938, Pf04055",51654,ENSG00000101391.20,CDK5RAP1,20,,,,0,High,1
O75629,Protein CREG1 OS=Homo sapiens OX=9606 GN=CREG1 PE=1 SV=1,0,16.648,20,3,27,3,220,24.1,7.59,8698,,3,,cell proliferation;development;regulation of biological process;transport,extracellular;organelle lumen,protein binding,Pf13883,8804,ENSG00000143162.7,CREG1,1,,Senescence and Autophagy in Cancer,Neutrophil degranulation,4,High,1
Q13643,Four and a half LIM domains protein 3 OS=Homo sapiens OX=9606 GN=FHL3 PE=1 SV=4,0,16.624,12,4,24,4,280,31.2,6.2,9393,,4,,cell organization and biogenesis,nucleus,metal ion binding;protein binding,Pf00412,2275,ENSG00000183386.9,FHL3,1,,,,0,High,1
P07101,Tyrosine 3-monooxygenase OS=Homo sapiens OX=9606 GN=TH PE=1 SV=5,0,16.624,8,4,13,4,528,58.6,6.3,5327,,4,,cell communication;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;membrane;mitochondrion;nucleus,catalytic activity;metal ion binding;protein binding,"Pf00351, Pf12549",7054,ENSG00000180176.14,TH,11,Cocaine addiction; Dopaminergic synapse; Metabolic pathways; Amphetamine addiction; Tyrosine metabolism; Alcoholism; Parkinson's disease; Prolactin signaling pathway,Nicotine Activity on Dopaminergic Neurons; Parkinsons Disease Pathway; Dopamine metabolism; Dopaminergic Neurogenesis; Amino Acid metabolism; Biogenic Amine Synthesis; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways; Monoamine Transport,Catecholamine biosynthesis,20,High,1
P50479,PDZ and LIM domain protein 4 OS=Homo sapiens OX=9606 GN=PDLIM4 PE=1 SV=2,0,16.599,20,5,11,5,330,35.4,7.91,3989,,5,,cell organization and biogenesis,cytoplasm;cytoskeleton;nucleus;organelle lumen,metal ion binding;protein binding,"Pf00412, Pf00595",8572,ENSG00000131435.12,PDLIM4,5,,,,0,High,1
Q15714,TSC22 domain family protein 1 OS=Homo sapiens OX=9606 GN=TSC22D1 PE=1 SV=3,0,16.525,3,4,20,1,1073,109.6,5.64,8176,,4,,cell organization and biogenesis;metabolic process;regulation of biological process;reproduction,cytoplasm;nucleus,protein binding,"Pf01166, Pf04977, Pf06005, Pf06156, Pf09770",8848,ENSG00000102804.14,TSC22D1,13,,Ectoderm Differentiation,,1,High,1
P00156,Cytochrome b OS=Homo sapiens OX=9606 GN=MT-CYB PE=1 SV=2,0,16.52,7,3,57,3,380,42.7,8.05,25801,,3,,metabolic process;response to stimulus;transport,membrane;mitochondrion,catalytic activity;metal ion binding;protein binding;transporter activity,"Pf00032, Pf00033, Pf13631",4519,ENSG00000198727.2,CYTB,MT,Parkinson's disease; Metabolic pathways; Alzheimer's disease; Non-alcoholic fatty liver disease (NAFLD); Cardiac muscle contraction; Oxidative phosphorylation; Huntington's disease,Electron Transport Chain,Respiratory electron transport,12,High,1
Q6IN85,Serine/threonine-protein phosphatase 4 regulatory subunit 3A OS=Homo sapiens OX=9606 GN=PPP4R3A PE=1 SV=1,0,16.509,6,4,6,4,833,95.3,4.94,2345,,4,,,cytoplasm;cytoskeleton;nucleus,,Pf04802,55671,ENSG00000100796.17,SMEK1; PPP4R3A,14,Glucagon signaling pathway,Integrated Breast Cancer Pathway,,2,High,1
Q8N1T3,Unconventional myosin-Ih OS=Homo sapiens OX=9606 GN=MYO1H PE=1 SV=2,0,16.502,1,1,11,1,1032,119,9.09,5834,,1,,,,catalytic activity;motor activity;nucleotide binding;protein binding,"Pf00063, Pf06017",283446,,MYO1H,12,,,,0,High,1
O00479,High mobility group nucleosome-binding domain-containing protein 4 OS=Homo sapiens OX=9606 GN=HMGN4 PE=1 SV=3,0,16.484,17,2,108,2,90,9.5,10.48,44551,,2,,,chromosome;nucleus,DNA binding;protein binding,,10473,ENSG00000182952.4,HMGN4,6,,,,0,High,1
P62861,40S ribosomal protein S30 OS=Homo sapiens OX=9606 GN=FAU PE=1 SV=1,0,16.481,19,2,82,2,59,6.6,12.15,45533,,2,,cell organization and biogenesis;defense response;metabolic process;response to stimulus;transport,cytosol;ribosome,RNA binding;structural molecule activity,Pf04758,2197,,FAU,11,,Cytoplasmic Ribosomal Proteins,"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane",37,High,1
O14976,Cyclin-G-associated kinase OS=Homo sapiens OX=9606 GN=GAK PE=1 SV=2,0,16.473,3,3,12,3,1311,143.1,5.73,5338,,3,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;Golgi;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf00226, Pf07714, Pf10409",2580,ENSG00000178950.16,GAK,4,,,Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis,6,High,1
P56377,AP-1 complex subunit sigma-2 OS=Homo sapiens OX=9606 GN=AP1S2 PE=1 SV=1,0,16.455,25,4,11,2,157,18.6,5.47,4266,,4,,regulation of biological process;transport,cytosol;Golgi;membrane,protein binding;transporter activity,Pf01217,8905,ENSG00000182287.13,AP1S2,X,Lysosome,,Nef mediated downregulation of MHC class I complex cell surface expression; MHC class II antigen presentation; Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis,17,High,1
Q14657,EKC/KEOPS complex subunit LAGE3 OS=Homo sapiens OX=9606 GN=LAGE3 PE=1 SV=2,0,16.437,45,3,13,3,143,14.8,8.63,4651,,3,,metabolic process,nucleus,protein binding,Pf09341,8270,ENSG00000196976.7,LAGE3,X,,,tRNA modification in the nucleus and cytosol,3,High,1
Q7Z304,MAM domain-containing protein 2 OS=Homo sapiens OX=9606 GN=MAMDC2 PE=2 SV=3,0,16.436,7,4,8,4,686,77.5,5.16,3656,,4,,,endoplasmic reticulum;extracellular;membrane,,Pf00629,256691,ENSG00000165072.9,MAMDC2,9,,,,0,High,1
Q9Y4B6,DDB1- and CUL4-associated factor 1 OS=Homo sapiens OX=9606 GN=DCAF1 PE=1 SV=3,0,16.43,3,5,67,4,1507,168.9,5.06,30245,,5,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;nucleus,catalytic activity;nucleotide binding;protein binding,,9730,ENSG00000145041.15,VPRBP; DCAF1,3,,,Antigen processing: Ubiquitination & Proteasome degradation,4,High,1
Q9H0R3,Transmembrane protein 222 OS=Homo sapiens OX=9606 GN=TMEM222 PE=1 SV=2,0,16.413,29,3,10,3,208,23.2,6.51,3924,,3,,,membrane,,Pf05608,84065,ENSG00000186501.14,TMEM222,1,,,,0,High,1
Q99567,Nuclear pore complex protein Nup88 OS=Homo sapiens OX=9606 GN=NUP88 PE=1 SV=2,0,16.401,8,4,9,4,741,83.5,5.69,3318,,4,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;transport,cytosol;nucleus,protein binding;transporter activity,"Pf02050, Pf07767, Pf09789, Pf10168",4927,ENSG00000108559.11,NUP88,17,RNA transport,,Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins,64,High,1
Q8NFU3,Thiosulfate:glutathione sulfurtransferase OS=Homo sapiens OX=9606 GN=TSTD1 PE=1 SV=3,0,16.392,56,4,15,4,115,12.5,6.07,7217,,4,,metabolic process,cytoplasm;cytosol;mitochondrion,catalytic activity,"Pf00581, Pf14566",100131187,ENSG00000215845.10,TSTD1,1,,,Sulfide oxidation to sulfate,5,High,1
P61964,WD repeat-containing protein 5 OS=Homo sapiens OX=9606 GN=WDR5 PE=1 SV=1,0,16.379,17,5,12,5,334,36.6,8.27,3853,,5,,cell organization and biogenesis;metabolic process;regulation of biological process,nucleus,catalytic activity;protein binding,"Pf00400, Pf08662, Pf11715",11091,ENSG00000196363.9,WDR5,9,,,RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RMTs methylate histone arginines; PKMTs methylate histone lysines; HATs acetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Neddylation,16,High,1
P98194,Calcium-transporting ATPase type 2C member 1 OS=Homo sapiens OX=9606 GN=ATP2C1 PE=1 SV=3,0,16.371,6,4,7,4,919,100.5,6.74,2634,0,3,1,cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport,Golgi;membrane,catalytic activity;metal ion binding;nucleotide binding;signal transducer activity;transporter activity,"Pf00122, Pf00689, Pf00690, Pf00702, Pf08282, Pf12710, Pf13246",27032,ENSG00000017260.19,ATP2C1,3,,,Ion transport by P-type ATPases,3,High,1
Q9HAV4,Exportin-5 OS=Homo sapiens OX=9606 GN=XPO5 PE=1 SV=1,0,16.37,5,4,10,4,1204,136.2,5.8,3269,,4,,metabolic process;regulation of biological process;transport,cytoplasm;cytosol;nucleus,protein binding;RNA binding;transporter activity,Pf08389,57510,ENSG00000124571.17,XPO5,6,RNA transport,miRNA Biogenesis; RNA interference,MicroRNA (miRNA) biogenesis,6,High,1
Q99595,Mitochondrial import inner membrane translocase subunit Tim17-A OS=Homo sapiens OX=9606 GN=TIMM17A PE=1 SV=1,0,16.352,12,1,14,1,171,18,7.87,7982,,1,,transport,membrane;mitochondrion,transporter activity,Pf02466,10440,ENSG00000134375.10,TIMM17A,1,,,Mitochondrial protein import; Metabolism of proteins,2,High,1
Q96AD5,Patatin-like phospholipase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=PNPLA2 PE=1 SV=1,0,16.342,11,5,17,5,504,55.3,7.08,6434,,5,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;organelle lumen,catalytic activity,Pf01734,57104,ENSG00000177666.16,PNPLA2,11,Regulation of lipolysis in adipocytes; Glycerolipid metabolism; Metabolic pathways,Fatty Acid Beta Oxidation; Triacylglyceride Synthesis,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Acyl chain remodeling of DAG and TAG,14,High,1
A6NDU8,UPF0600 protein C5orf51 OS=Homo sapiens OX=9606 GN=C5orf51 PE=1 SV=1,0,16.338,13,3,18,3,294,33.6,5.26,6828,,3,,,cytosol,,,285636,ENSG00000205765.8,C5orf51,5,,,,0,High,1
Q6UB28,"Methionine aminopeptidase 1D, mitochondrial OS=Homo sapiens OX=9606 GN=METAP1D PE=1 SV=1",0,16.33,14,3,14,3,335,37.1,6.84,4063,,3,,metabolic process,mitochondrion,catalytic activity;metal ion binding,Pf00557,254042,ENSG00000172878.13,METAP1D,2,,,,0,High,1
O60231,Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 OS=Homo sapiens OX=9606 GN=DHX16 PE=1 SV=2,0,16.326,4,4,20,4,1041,119.2,6.8,9793,,4,,metabolic process,cytoplasm;nucleus;spliceosomal complex,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00271, Pf04408, Pf07717",8449,ENSG00000233561.6; ENSG00000226171.6; ENSG00000233049.6; ENSG00000204560.9; ENSG00000233418.8; ENSG00000231377.6,DHX16,6; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_MCF_CTG1,Spliceosome,mRNA Processing,mRNA Splicing - Major Pathway,6,High,1
Q7KYR7,Butyrophilin subfamily 2 member A1 OS=Homo sapiens OX=9606 GN=BTN2A1 PE=1 SV=3,0,16.303,8,3,13,3,527,59.6,6.48,4522,,3,,metabolic process,membrane,protein binding,"Pf00047, Pf00622, Pf08205, Pf13765",11120,ENSG00000112763.15,BTN2A1,6,,,Butyrophilin (BTN) family interactions,3,High,1
Q9H8W4,Pleckstrin homology domain-containing family F member 2 OS=Homo sapiens OX=9606 GN=PLEKHF2 PE=1 SV=1,0,16.294,17,4,16,4,249,27.8,8.21,6140,,4,,transport,endoplasmic reticulum;endosome;membrane,metal ion binding;protein binding,"Pf00169, Pf01363",79666,ENSG00000175895.3,PLEKHF2,8,,,,0,High,1
Q9H7F0,Probable cation-transporting ATPase 13A3 OS=Homo sapiens OX=9606 GN=ATP13A3 PE=1 SV=4,0,16.278,5,5,18,5,1226,138,6.64,6879,,5,,cellular homeostasis;transport,membrane,catalytic activity;metal ion binding;nucleotide binding;transporter activity,"Pf00122, Pf00690, Pf00702, Pf12409, Pf13246",79572,ENSG00000133657.14,ATP13A3,3,,,,0,High,1
Q9H6V9,Lipid droplet-associated hydrolase OS=Homo sapiens OX=9606 GN=LDAH PE=1 SV=1,0,16.278,15,4,10,4,325,37.3,6.54,4992,,4,,metabolic process,endoplasmic reticulum,catalytic activity,"Pf10230, Pf12695, Pf12697",60526,ENSG00000118961.14,C2orf43; LDAH,2,,,,0,High,1
Q9P0N9,TBC1 domain family member 7 OS=Homo sapiens OX=9606 GN=TBC1D7 PE=1 SV=1,0,16.276,12,3,14,3,293,34,7.94,6335,,3,,regulation of biological process;response to stimulus,cytosol,enzyme regulator activity;protein binding,Pf00566,51256; 107080638,ENSG00000145979.17,TBC1D7; TBC1D7-LOC100130357,6,mTOR signaling pathway,,TBC/RABGAPs,5,High,1
Q9ULH1,"Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ASAP1 PE=1 SV=4",0,16.274,4,4,16,4,1129,125.4,7.31,5406,,4,,cell organization and biogenesis;regulation of biological process,cytoplasm;cytosol;membrane,enzyme regulator activity;metal ion binding;protein binding,"Pf00018, Pf00023, Pf00169, Pf01412, Pf12796, Pf13637, Pf13857, Pf14604",50807,ENSG00000153317.14,ASAP1,8,Endocytosis; Fc gamma R-mediated phagocytosis,EGF/EGFR Signaling Pathway,VxPx cargo-targeting to cilium,7,High,1
P07477,Trypsin-1 OS=Homo sapiens OX=9606 GN=PRSS1 PE=1 SV=1,0,16.244,8,2,41,1,247,26.5,6.51,13334,2.34,2,1,cell organization and biogenesis;metabolic process,extracellular,catalytic activity;metal ion binding,Pf00089,5644,ENSG00000274247.4; ENSG00000204983.13,PRSS1,7; CHR_HSCHR7_2_CTG6,Protein digestion and absorption; Pancreatic secretion; Neuroactive ligand-receptor interaction; Influenza A,,"Activation of Matrix Metalloproteinases; Cobalamin (Cbl, vitamin B12) transport and metabolism",11,High,1
Q9Y5X2,Sorting nexin-8 OS=Homo sapiens OX=9606 GN=SNX8 PE=1 SV=1,0,16.242,10,4,25,4,465,52.5,7.39,8266,,4,,cell organization and biogenesis;transport,cytosol;endosome;membrane,protein binding,Pf00787,29886,ENSG00000106266.10,SNX8,7,,,,0,High,1
Q96NT0,Coiled-coil domain-containing protein 115 OS=Homo sapiens OX=9606 GN=CCDC115 PE=1 SV=1,0,16.216,29,3,14,3,180,19.7,6.95,5372,,3,,cellular homeostasis;response to stimulus,endoplasmic reticulum;endosome;membrane;vacuole,protein binding,,84317,ENSG00000136710.9,CCDC115,2,,,,0,High,1
P42338,"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform OS=Homo sapiens OX=9606 GN=PIK3CB PE=1 SV=1",0,16.187,5,4,13,4,1070,122.7,7.09,4365,,4,,cell division;cell proliferation;cellular component movement;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00454, Pf00613, Pf00792, Pf00794, Pf02192",5291,ENSG00000051382.8,PIK3CB,3,cGMP-PKG signaling pathway; ErbB signaling pathway; Jak-STAT signaling pathway; Inflammatory mediator regulation of TRP channels; Platelet activation; Pancreatic cancer; Breast cancer; HTLV-I infection; Measles; Insulin resistance; Osteoclast differentiation; Rap1 signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Regulation of actin cytoskeleton; Signaling pathways regulating pluripotency of stem cells; Longevity regulating pathway - multiple species; Neurotrophin signaling pathway; Thyroid hormone signaling pathway; AMPK signaling pathway; Fc gamma R-mediated phagocytosis; Prolactin signaling pathway; Type II diabetes mellitus; Apoptosis; Toll-like receptor signaling pathway; Longevity regulating pathway; HIF-1 signaling pathway; Oxytocin signaling pathway; Melanoma; Sphingolipid signaling pathway; Estrogen signaling pathway; T cell receptor signaling pathway; VEGF signaling pathway; Phosphatidylinositol signaling system; Aldosterone-regulated sodium reabsorption; Chemokine signaling pathway; Viral carcinogenesis; Chronic myeloid leukemia; Pathways in cancer; Proteoglycans in cancer; Hepatitis C; Platinum drug resistance; Hepatitis B; Non-small cell lung cancer; Renal cell carcinoma; Leukocyte transendothelial migration; cAMP signaling pathway; Phospholipase D signaling pathway; Natural killer cell mediated cytotoxicity; Focal adhesion; Fc epsilon RI signaling pathway; PI3K-Akt signaling pathway; TNF signaling pathway; Acute myeloid leukemia; Adrenergic signaling in cardiomyocytes; Carbohydrate digestion and absorption; Axon guidance; FoxO signaling pathway; Colorectal cancer; Toxoplasmosis; Small cell lung cancer; Cholinergic synapse; Amoebiasis; B cell receptor signaling pathway; Glioma; mTOR signaling pathway; Endocrine resistance; Central carbon metabolism in cancer; Endometrial cancer; EGFR tyrosine kinase inhibitor resistance; Bacterial invasion of epithelial cells; Regulation of lipolysis in adipocytes; Chagas disease (American trypanosomiasis); Epstein-Barr virus infection; Prostate cancer; Choline metabolism in cancer; Ras signaling pathway; Insulin signaling pathway; Progesterone-mediated oocyte maturation; Inositol phosphate metabolism; Non-alcoholic fatty liver disease (NAFLD); Influenza A,AMP-activated Protein Kinase (AMPK) Signaling; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Prolactin Signaling Pathway; Signaling Pathways in Glioblastoma; Focal Adhesion; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Angiopoietin Like Protein 8 Regulatory Pathway; Chemokine signaling pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Microglia Pathogen Phagocytosis Pathway; Insulin Signaling; Regulation of Actin Cytoskeleton; G13 Signaling Pathway; DNA Damage Response (only ATM dependent); Toll-like receptor signaling pathway,"PI3K Cascade; Tie2 Signaling; Downstream TCR signaling; G beta:gamma signalling through PI3Kgamma; Interleukin-7 signaling; Downstream signal transduction; PI3K/AKT activation; Nephrin family interactions; DAP12 signaling; Regulation of signaling by CBL; Constitutive Signaling by Aberrant PI3K in Cancer; Role of phospholipids in phagocytosis; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; VEGFA-VEGFR2 Pathway; Interleukin receptor SHC signaling; GPVI-mediated activation cascade; RET signaling; Synthesis of PIPs at the plasma membrane; Role of LAT2/NTAL/LAB on calcium mobilization",158,High,1
P15056,Serine/threonine-protein kinase B-raf OS=Homo sapiens OX=9606 GN=BRAF PE=1 SV=4,0,16.173,5,4,17,1,766,84.4,7.53,5744,,4,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;mitochondrion;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf00130, Pf02196, Pf07714, Pf14531",673,ENSG00000157764.12,BRAF,7,Vascular smooth muscle contraction; Pathways in cancer; Endocrine resistance; Endometrial cancer; Regulation of actin cytoskeleton; Rap1 signaling pathway; Focal adhesion; Pancreatic cancer; Long-term potentiation; cAMP signaling pathway; Serotonergic synapse; Natural killer cell mediated cytotoxicity; Hepatitis C; Progesterone-mediated oocyte maturation; mTOR signaling pathway; Neurotrophin signaling pathway; Melanoma; Breast cancer; Bladder cancer; FoxO signaling pathway; Glioma; MAPK signaling pathway; Long-term depression; Insulin signaling pathway; Prostate cancer; Chemokine signaling pathway; Non-small cell lung cancer; Proteoglycans in cancer; Dorso-ventral axis formation; ErbB signaling pathway; Alcoholism; Acute myeloid leukemia; EGFR tyrosine kinase inhibitor resistance; Colorectal cancer; Thyroid cancer; Chronic myeloid leukemia; Renal cell carcinoma,Integrin-mediated Cell Adhesion; Human Thyroid Stimulating Hormone (TSH) signaling pathway; Signaling Pathways in Glioblastoma; B Cell Receptor Signaling Pathway; Corticotropin-releasing hormone signaling pathway; Bladder Cancer; Focal Adhesion; BDNF-TrkB Signaling; MAPK Signaling Pathway; Chemokine signaling pathway; ESC Pluripotency Pathways; MAPK Cascade; EGF/EGFR Signaling Pathway; Regulation of Actin Cytoskeleton; Senescence and Autophagy in Cancer; Estrogen signaling pathway; Serotonin Receptor 4/6/7 and NR3C Signaling,Spry regulation of FGF signaling; Signaling by BRAF and RAF fusions; MAP2K and MAPK activation; Signalling to p38 via RIT and RIN; ARMS-mediated activation; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; Negative feedback regulation of MAPK pathway; Paradoxical activation of RAF signaling by kinase inactive BRAF; Frs2-mediated activation; CREB phosphorylation through the activation of Ras; RAF activation; Interleukin-20 family signaling,98,High,1
Q93063,Exostosin-2 OS=Homo sapiens OX=9606 GN=EXT2 PE=1 SV=1,0,16.162,6,3,8,3,718,82.2,6.55,3422,,3,,cell differentiation;metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;Golgi;membrane,catalytic activity;metal ion binding;protein binding,"Pf03016, Pf09258",2132,ENSG00000151348.13,EXT2,11,Glycosaminoglycan biosynthesis - heparan sulfate / heparin; Metabolic pathways,Mesodermal Commitment Pathway,HS-GAG biosynthesis; Defective EXT2 causes exostoses 2,12,High,1
P46100,Transcriptional regulator ATRX OS=Homo sapiens OX=9606 GN=ATRX PE=1 SV=5,0,16.141,2,4,12,4,2492,282.4,6.58,4302,,4,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;nucleus,catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding,"Pf00176, Pf00271",546,,ATRX,X,,Pathways Affected in Adenoid Cystic Carcinoma,,1,High,1
Q96AJ9-1,Isoform 1 of Vesicle transport through interaction with t-SNAREs homolog 1A OS=Homo sapiens OX=9606 GN=VTI1A,0,16.132,15,3,14,3,203,23.4,6.15,6693,,3,,cell organization and biogenesis;metabolic process;transport,cytosol;endosome;Golgi;membrane;vacuole,protein binding,"Pf05008, Pf12352",143187,ENSG00000151532.13,VTI1A,10,,,,0,High,1
Q9H2P0,Activity-dependent neuroprotector homeobox protein OS=Homo sapiens OX=9606 GN=ADNP PE=1 SV=1,0,16.13,4,3,7,3,1102,123.5,7.34,4222,,3,,cell communication;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,DNA binding;metal ion binding;protein binding,"Pf00046, Pf12756, Pf13909",23394,ENSG00000101126.15,ADNP,20,,,,0,High,1
Q32P28,Prolyl 3-hydroxylase 1 OS=Homo sapiens OX=9606 GN=P3H1 PE=1 SV=2,0,16.125,5,3,12,3,736,83.3,5.14,6176,,3,,metabolic process;regulation of biological process,endoplasmic reticulum;extracellular;membrane;organelle lumen,catalytic activity;metal ion binding;protein binding,Pf13640,64175,ENSG00000117385.15,LEPRE1; P3H1,1,,,Collagen biosynthesis and modifying enzymes,3,High,1
P02749,Beta-2-glycoprotein 1 OS=Homo sapiens OX=9606 GN=APOH PE=1 SV=3,0,16.118,11,4,44,4,345,38.3,7.97,15547,2.32,3,1,metabolic process;regulation of biological process;response to stimulus;transport,cell surface;extracellular;organelle lumen,enzyme regulator activity;protein binding,"Pf00084, Pf09014",350,ENSG00000091583.10,APOH,17,,,Platelet degranulation,4,High,1
P61165,Transmembrane protein 258 OS=Homo sapiens OX=9606 GN=TMEM258 PE=1 SV=1,0,16.073,10,2,26,2,79,9.1,5.83,13268,,2,,metabolic process,endoplasmic reticulum;membrane,,Pf05251,746,ENSG00000134825.15,C11orf10; TMEM258,11,,,,0,High,1
Q9BW83,Intraflagellar transport protein 27 homolog OS=Homo sapiens OX=9606 GN=IFT27 PE=1 SV=1,0,16.058,24,3,15,3,186,20.5,5.41,6899,,3,,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport,endosome;Golgi,catalytic activity;nucleotide binding;protein binding,"Pf00071, Pf08477",11020,ENSG00000100360.14,IFT27,22,,,Intraflagellar transport,3,High,1
Q9BTX1,Nucleoporin NDC1 OS=Homo sapiens OX=9606 GN=NDC1 PE=1 SV=2,0,16.054,9,3,7,3,674,76.3,9.09,2674,,3,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;membrane;nucleus,structural molecule activity,Pf09531,55706,ENSG00000058804.11,NDC1; TMEM48,1,RNA transport,,Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins,64,High,1
P02724,Glycophorin-A OS=Homo sapiens OX=9606 GN=GYPA PE=1 SV=2,0,16.046,21,2,15,2,150,16.3,5.47,8099,,2,,cellular component movement,membrane,protein binding;receptor activity,Pf01102,2993,,GYPA,4,Malaria; Hematopoietic cell lineage,,Cell surface interactions at the vascular wall,4,High,1
O00194,Ras-related protein Rab-27B OS=Homo sapiens OX=9606 GN=RAB27B PE=1 SV=4,0,16.029,18,4,71,1,218,24.6,5.52,34482,0,4,2,regulation of biological process;response to stimulus;transport,Golgi;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00009, Pf00025, Pf00071, Pf04670, Pf08477",5874,ENSG00000041353.9,RAB27B,18,Pancreatic secretion,Deregulation of Rab and Rab Effector Genes in Bladder Cancer,Platelet degranulation ; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation,13,High,1
Q9UHI6,Probable ATP-dependent RNA helicase DDX20 OS=Homo sapiens OX=9606 GN=DDX20 PE=1 SV=2,0,16.009,7,4,19,4,824,92.2,6.95,7645,,4,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding,"Pf00270, Pf00271",11218,ENSG00000064703.11,DDX20,1,RNA transport,mRNA Processing,snRNP Assembly,5,High,1
Q99808,Equilibrative nucleoside transporter 1 OS=Homo sapiens OX=9606 GN=SLC29A1 PE=1 SV=3,0,16.008,6,2,15,2,456,50.2,8.29,7099,,2,,cellular homeostasis;metabolic process;response to stimulus;transport,membrane,transporter activity,Pf01733,2030,ENSG00000112759.16,SLC29A1,6,Alcoholism,Fluoropyrimidine Activity,Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane,6,High,1
Q92615,La-related protein 4B OS=Homo sapiens OX=9606 GN=LARP4B PE=1 SV=3,0,16.005,5,3,9,3,738,80.5,6.92,3042,,3,,regulation of biological process,cytoplasm;cytosol;membrane;ribosome,protein binding;RNA binding,"Pf05383, Pf14259",23185,ENSG00000107929.14,LARP4B,10,,,,0,High,1
Q9UKA9,Polypyrimidine tract-binding protein 2 OS=Homo sapiens OX=9606 GN=PTBP2 PE=1 SV=1,0,15.997,16,5,11,5,531,57.5,8.66,3336,,5,,cell organization and biogenesis;metabolic process;regulation of biological process,nucleus;spliceosomal complex,RNA binding,"Pf00076, Pf13893, Pf14259",58155,ENSG00000117569.18,PTBP2,1,,TarBasePathway; mRNA Processing,,2,High,1
Q2TAL8,Glutamine-rich protein 1 OS=Homo sapiens OX=9606 GN=QRICH1 PE=1 SV=1,0,15.995,7,3,4,3,776,86.4,5.87,1540,,3,,cell organization and biogenesis;development;regulation of biological process,cytoplasm,DNA binding;protein binding,"Pf00619, Pf12012",54870,ENSG00000198218.10,QRICH1,3,,,,0,High,1
P19793,Retinoic acid receptor RXR-alpha OS=Homo sapiens OX=9606 GN=RXRA PE=1 SV=1,0,15.99,10,3,6,3,462,50.8,7.8,2375,,3,,cell differentiation;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport,nucleus,DNA binding;metal ion binding;protein binding;receptor activity;signal transducer activity,"Pf00104, Pf00105, Pf11825",6256,ENSG00000186350.9,RXRA,9,Thyroid hormone signaling pathway; PPAR signaling pathway; Hepatitis C; Non-alcoholic fatty liver disease (NAFLD); Pathways in cancer; Bile secretion; Adipocytokine signaling pathway; Small cell lung cancer; PI3K-Akt signaling pathway; Thyroid cancer; Transcriptional misregulation in cancer; Non-small cell lung cancer,Vitamin D Metabolism; Energy Metabolism; Nuclear Receptors; Adipogenesis; Liver X Receptor Pathway; Constitutive Androstane Receptor Pathway; PPAR Alpha Pathway; Farnesoid X Receptor  Pathway; NRF2 pathway; Transcription factor regulation in adipogenesis; Angiopoietin Like Protein 8 Regulatory Pathway; PPAR signaling pathway; Vitamin A and Carotenoid Metabolism,"Import of palmitoyl-CoA into the mitochondrial matrix; Transcriptional regulation of white adipocyte differentiation; Endogenous sterols; Activation of gene expression by SREBF (SREBP); RORA activates gene expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Signaling by Retinoic Acid; PPARA activates gene expression; Nuclear Receptor transcription pathway; YAP1- and WWTR1 (TAZ)-stimulated gene expression; Transcriptional activation of mitochondrial biogenesis; Synthesis of bile acids and bile salts via 27-hydroxycholesterol; Regulation of pyruvate dehydrogenase (PDH) complex; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Recycling of bile acids and salts; BMAL1:CLOCK,NPAS2 activates circadian gene expression; RUNX3 regulates YAP1-mediated transcription",67,High,1
Q9BT09,Protein canopy homolog 3 OS=Homo sapiens OX=9606 GN=CNPY3 PE=1 SV=1,0,15.962,12,3,12,3,278,30.7,5.49,5320,,3,,defense response;regulation of biological process;response to stimulus,endoplasmic reticulum;organelle lumen,protein binding,Pf11938,10695,ENSG00000137161.16,CNPY3,6,,,Trafficking and processing of endosomal TLR,4,High,1
Q14CS0,UBX domain-containing protein 2B OS=Homo sapiens OX=9606 GN=UBXN2B PE=1 SV=1,0,15.95,20,4,6,4,331,37.1,5.64,1862,2.05,3,1,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;endoplasmic reticulum;Golgi;nucleus,enzyme regulator activity;protein binding,"Pf00789, Pf08059",137886,ENSG00000215114.8,UBXN2B,8,,,,0,High,1
Q8N961,Ankyrin repeat and BTB/POZ domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ABTB2 PE=2 SV=2,0,15.931,6,4,9,4,1025,113.6,6.29,3140,0,3,1,metabolic process;regulation of biological process;response to stimulus,cytoplasm,protein binding,"Pf00023, Pf00651, Pf12796, Pf13606, Pf13637, Pf13857",25841,ENSG00000166016.5,ABTB2,11,,,,0,High,1
Q8TB96,T-cell immunomodulatory protein OS=Homo sapiens OX=9606 GN=ITFG1 PE=1 SV=1,0,15.91,7,3,7,3,612,68.1,5.39,2911,1.69,3,1,,extracellular;membrane,,Pf13517,81533,ENSG00000129636.12,ITFG1,16,,,,0,High,1
Q13907,Isopentenyl-diphosphate Delta-isomerase 1 OS=Homo sapiens OX=9606 GN=IDI1 PE=1 SV=2,0,15.88,18,3,15,3,227,26.3,6.34,5740,,3,,metabolic process;regulation of biological process,cytosol,catalytic activity;metal ion binding,Pf00293,3422,,IDI1,10,Metabolic pathways; Terpenoid backbone biosynthesis,Target Of Rapamycin (TOR) Signaling; Cholesterol Biosynthesis; Sterol Regulatory Element-Binding Proteins (SREBP) signalling; Exercise-induced Circadian Regulation,Cholesterol biosynthesis; Activation of gene expression by SREBF (SREBP),12,High,1
P26358,DNA (cytosine-5)-methyltransferase 1 OS=Homo sapiens OX=9606 GN=DNMT1 PE=1 SV=2,0,15.875,3,4,15,4,1616,183.1,7.75,5836,,4,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,nucleus,catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding,"Pf00145, Pf01426, Pf02008, Pf06464, Pf12047",1786,ENSG00000130816.14,DNMT1,19,MicroRNAs in cancer; Cysteine and methionine metabolism; Metabolic pathways,Trans-sulfuration pathway; One Carbon Metabolism; Retinoblastoma (RB) in Cancer; Trans-sulfuration and one carbon metabolism; Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex,PRC2 methylates histones and DNA; DNA methylation; NoRC negatively regulates rRNA expression,14,High,1
O14733,Dual specificity mitogen-activated protein kinase kinase 7 OS=Homo sapiens OX=9606 GN=MAP2K7 PE=1 SV=2,0,15.863,15,5,16,5,419,47.5,9.16,4602,,5,,cell death;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf07714, Pf14531",5609,ENSG00000076984.17,MAP2K7,19,Fc epsilon RI signaling pathway; Neurotrophin signaling pathway; T cell receptor signaling pathway; Influenza A; Protein processing in endoplasmic reticulum; Osteoclast differentiation; MAPK signaling pathway; Epstein-Barr virus infection; GnRH signaling pathway; TNF signaling pathway; Toll-like receptor signaling pathway; ErbB signaling pathway,Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; Signaling Pathways in Glioblastoma; TNF alpha Signaling Pathway; Structural Pathway of Interleukin 1 (IL-1); Cardiac Hypertrophic Response; MAPK Signaling Pathway; ERK Pathway in Huntington's Disease; T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; MAPK Cascade; Insulin Signaling; ErbB Signaling Pathway; Toll-like receptor signaling pathway,Uptake and function of anthrax toxins; FCERI mediated MAPK activation; Activated TLR4 signalling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; Oxidative Stress Induced Senescence,63,High,1
Q8N474,Secreted frizzled-related protein 1 OS=Homo sapiens OX=9606 GN=SFRP1 PE=1 SV=1,0,15.863,16,4,12,4,314,35.4,8.85,4360,,4,,cell communication;cell differentiation;development;metabolic process;regulation of biological process;response to stimulus,cell surface;cytosol;extracellular;membrane,catalytic activity;protein binding;receptor activity;signal transducer activity,"Pf01392, Pf01759",6422,ENSG00000104332.11,SFRP1,8,Wnt signaling pathway,Endoderm Differentiation; BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation; BMP Signaling Pathway in Eyelid Development,Negative regulation of TCF-dependent signaling by WNT ligand antagonists,8,High,1
Q96MX6,WD repeat-containing protein 92 OS=Homo sapiens OX=9606 GN=WDR92 PE=1 SV=1,0,15.852,17,3,17,3,357,39.7,8.09,6318,,3,,cell death,,protein binding,,116143,ENSG00000243667.6,WDR92,2,,,,0,High,1
Q99962,Endophilin-A1 OS=Homo sapiens OX=9606 GN=SH3GL2 PE=1 SV=1,0,15.851,13,4,23,1,352,39.9,5.45,10806,0,4,1,cell growth;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane,protein binding,"Pf00018, Pf03114, Pf07653, Pf10455, Pf14604",6456,ENSG00000107295.9,SH3GL2,9,Endocytosis,EGF/EGFR Signaling Pathway,Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Golgi Associated Vesicle Biogenesis; Recycling pathway of L1; Lysosome Vesicle Biogenesis; Negative regulation of MET activity; Retrograde neurotrophin signalling; InlB-mediated entry of Listeria monocytogenes into host cell; MHC class II antigen presentation,30,High,1
O95295,SNARE-associated protein Snapin OS=Homo sapiens OX=9606 GN=SNAPIN PE=1 SV=1,0,15.85,33,3,13,3,136,14.9,9.31,5683,,3,,cell communication;cell organization and biogenesis;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;Golgi;membrane;vacuole,protein binding,Pf14712,23557,ENSG00000143553.10,SNAPIN,1,,,Golgi Associated Vesicle Biogenesis,5,High,1
O14678,ATP-binding cassette sub-family D member 4 OS=Homo sapiens OX=9606 GN=ABCD4 PE=1 SV=1,0,15.846,8,4,7,4,606,68.6,6.55,2849,,4,,metabolic process;transport,membrane,catalytic activity;nucleotide binding;transporter activity,"Pf00005, Pf05992, Pf06472",5826,ENSG00000119688.20,ABCD4,14,ABC transporters; Peroxisome,,"Cobalamin (Cbl, vitamin B12) transport and metabolism; Defective ABCD4 causes methylmalonic aciduria and homocystinuria, cblj type (MAHCJ)",13,High,1
Q6ZT07,TBC1 domain family member 9 OS=Homo sapiens OX=9606 GN=TBC1D9 PE=2 SV=2,0,15.846,3,4,19,1,1266,143.1,5.31,6915,,4,,regulation of biological process;transport,,enzyme regulator activity;metal ion binding;protein binding,"Pf00566, Pf02893",23158,ENSG00000109436.7,TBC1D9,4,,,,0,High,1
Q92541,RNA polymerase-associated protein RTF1 homolog OS=Homo sapiens OX=9606 GN=RTF1 PE=1 SV=4,0,15.843,7,4,7,4,710,80.3,8.15,2412,,4,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,nucleus,DNA binding;protein binding;RNA binding,Pf03126,23168,ENSG00000137815.14,RTF1,15,,Endoderm Differentiation,E3 ubiquitin ligases ubiquitinate target proteins; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events,10,High,1
Q16822,"Phosphoenolpyruvate carboxykinase [GTP], mitochondrial OS=Homo sapiens OX=9606 GN=PCK2 PE=1 SV=4",0,15.842,8,5,14,5,640,70.7,7.62,4751,,5,,,,,,,,,,,,,0,High,1
Q969G6,Riboflavin kinase OS=Homo sapiens OX=9606 GN=RFK PE=1 SV=2,0,15.793,32,4,13,4,155,17.6,8.13,4719,,4,,cell death;metabolic process;regulation of biological process,cytoplasm;cytosol;mitochondrion,catalytic activity;metal ion binding;nucleotide binding;protein binding,Pf01687,55312,ENSG00000135002.11,RFK,9,Riboflavin metabolism; Metabolic pathways,Selenium Micronutrient Network; Folate Metabolism; TNF alpha Signaling Pathway,Vitamin B2 (riboflavin) metabolism,9,High,1
Q13123,Protein Red OS=Homo sapiens OX=9606 GN=IK PE=1 SV=3,0,15.79,10,4,16,4,557,65.6,6.64,5632,,4,,metabolic process;regulation of biological process,chromosome;cytoplasm;cytoskeleton;nucleus;spliceosomal complex,protein binding,"Pf07807, Pf07808",3550,ENSG00000113141.17,IK,5,,,,0,High,1
Q9H7P6,Multivesicular body subunit 12B OS=Homo sapiens OX=9606 GN=MVB12B PE=1 SV=2,0,15.743,12,3,6,3,319,35.6,8.15,1980,,3,,metabolic process;regulation of biological process;transport,cytosol;endosome;membrane;nucleus,protein binding,Pf10240,89853,ENSG00000196814.14,FAM125B; MVB12B,9,Endocytosis,,Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); Membrane binding and targetting of GAG proteins,13,High,1
Q75T13,GPI inositol-deacylase OS=Homo sapiens OX=9606 GN=PGAP1 PE=1 SV=1,0,15.74,6,4,10,4,922,105.3,9.01,2465,5.05,3,1,metabolic process;transport,endoplasmic reticulum;membrane,catalytic activity,"Pf07819, Pf12695, Pf12697",80055,ENSG00000197121.14,PGAP1,2,Metabolic pathways; Glycosylphosphatidylinositol (GPI)-anchor biosynthesis,,Attachment of GPI anchor to uPAR,6,High,1
A0A075B6R9,Probable non-functional immunoglobulin kappa variable 2D-24 OS=Homo sapiens OX=9606 GN=IGKV2D-24 PE=5 SV=1,0,15.719,33,3,40,3,120,13.1,8.87,19761,,3,,response to stimulus,,,,,ENSG00000241566.1,,2,,,,0,High,1
Q9Y6G3,"39S ribosomal protein L42, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL42 PE=1 SV=1",0,15.719,15,2,34,2,142,16.7,8.35,11231,,2,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,RNA binding;structural molecule activity,Pf10210,28977,ENSG00000198015.12,MRPL42,12,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
Q96Q42,Alsin OS=Homo sapiens OX=9606 GN=ALS2 PE=1 SV=2,0,15.711,5,4,9,4,1657,183.5,6.27,3187,,4,,cell communication;cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane,enzyme regulator activity;protein binding,"Pf00169, Pf00415, Pf00621, Pf02204, Pf02493, Pf13540",57679,ENSG00000003393.14,ALS2,2,Amyotrophic lateral sclerosis (ALS),Amyotrophic lateral sclerosis (ALS),RAB GEFs exchange GTP for GDP on RABs,6,High,1
Q9BYJ9,YTH domain-containing family protein 1 OS=Homo sapiens OX=9606 GN=YTHDF1 PE=1 SV=1,0,15.704,6,3,21,1,559,60.8,8.79,8534,,3,,regulation of biological process,cytoplasm,protein binding;RNA binding,Pf04146,54915,ENSG00000149658.17,YTHDF1,20,,,,0,High,1
Q69YN4,Protein virilizer homolog OS=Homo sapiens OX=9606 GN=VIRMA PE=1 SV=2,0,15.681,3,5,10,5,1812,201.9,5.01,3020,,5,,metabolic process,cytosol;nucleus,RNA binding,,25962,ENSG00000164944.11,KIAA1429; VIRMA,8,,,,0,High,1
P01709,Immunoglobulin lambda variable 2-8 OS=Homo sapiens OX=9606 GN=IGLV2-8 PE=1 SV=2,0,15.673,16,2,50,1,118,12.4,5.91,18241,,2,,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity,,28817,ENSG00000278196.3,IGLV2-8,22,,,FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis,26,High,1
P49746,Thrombospondin-3 OS=Homo sapiens OX=9606 GN=THBS3 PE=1 SV=1,0,15.631,5,4,12,2,956,104.1,4.65,4959,,4,,,extracellular,metal ion binding,"Pf02412, Pf05735, Pf11598",7059,ENSG00000169231.13,THBS3,1,ECM-receptor interaction; Focal adhesion; PI3K-Akt signaling pathway; Malaria; Phagosome,Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Inflammatory Response Pathway,Signaling by PDGF,11,High,1
Q9UJX2,Cell division cycle protein 23 homolog OS=Homo sapiens OX=9606 GN=CDC23 PE=1 SV=3,0,15.608,10,4,13,4,597,68.8,7.02,5721,,4,,cell division;metabolic process;regulation of biological process,cytosol,catalytic activity;protein binding,"Pf00515, Pf04049, Pf13414",8697,ENSG00000094880.10,CDC23,5,Cell cycle; Ubiquitin mediated proteolysis; HTLV-I infection; Oocyte meiosis; Progesterone-mediated oocyte maturation,,APC/C:Cdc20 mediated degradation of Cyclin B; Inactivation of APC/C via direct inhibition of the APC/C complex; Autodegradation of Cdh1 by Cdh1:APC/C; APC-Cdc20 mediated degradation of Nek2A; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Antigen processing: Ubiquitination & Proteasome degradation; Phosphorylation of the APC/C; APC/C:Cdc20 mediated degradation of Securin; Separation of Sister Chromatids; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Senescence-Associated Secretory Phenotype (SASP),37,High,1
Q96ST2,Protein IWS1 homolog OS=Homo sapiens OX=9606 GN=IWS1 PE=1 SV=2,0,15.606,4,3,17,3,819,91.9,4.69,7471,,3,,metabolic process;regulation of biological process;transport,nucleus,DNA binding;protein binding,"Pf05297, Pf08711, Pf09507",55677,ENSG00000163166.14,IWS1,2,,,Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events,5,High,1
O75113,NEDD4-binding protein 1 OS=Homo sapiens OX=9606 GN=N4BP1 PE=1 SV=4,0,15.603,6,4,20,4,896,100.3,5.36,7378,,4,,regulation of biological process;response to stimulus,nucleus,protein binding,Pf11977,9683,ENSG00000102921.7,N4BP1,16,,,,0,High,1
Q9BT73,Proteasome assembly chaperone 3 OS=Homo sapiens OX=9606 GN=PSMG3 PE=1 SV=1,0,15.596,51,4,10,4,122,13.1,7.88,3253,,4,,,proteasome,,Pf10178,84262,ENSG00000157778.8,PSMG3,7,,,,0,High,1
Q9NR77,Peroxisomal membrane protein 2 OS=Homo sapiens OX=9606 GN=PXMP2 PE=1 SV=3,0,15.584,18,5,13,5,195,22.2,10.58,4810,,5,,,cytoplasm;membrane,protein binding,Pf04117,5827,ENSG00000176894.9,PXMP2,12,Peroxisome,,Glyoxylate metabolism and glycine degradation,4,High,1
P18433,Receptor-type tyrosine-protein phosphatase alpha OS=Homo sapiens OX=9606 GN=PTPRA PE=1 SV=3,0,15.567,6,5,13,3,802,90.7,6.65,4553,0,4,1,,,,,,,,,,,,0,High,1
Q96SB3,Neurabin-2 OS=Homo sapiens OX=9606 GN=PPP1R9B PE=1 SV=3,0,15.567,7,4,12,4,817,89.3,4.97,4496,,4,,,,,,,,,,,,,0,High,1
P05121,Plasminogen activator inhibitor 1 OS=Homo sapiens OX=9606 GN=SERPINE1 PE=1 SV=1,0,15.564,9,3,7,3,402,45,7.2,3423,,3,,cell organization and biogenesis;defense response;regulation of biological process;response to stimulus;transport,extracellular;membrane;organelle lumen,enzyme regulator activity;protein binding,Pf00079,5054,ENSG00000106366.8,SERPINE1,7,AGE-RAGE signaling pathway in diabetic complications; Chagas disease (American trypanosomiasis); Complement and coagulation cascades; HIF-1 signaling pathway; p53 signaling pathway; Hippo signaling pathway,Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism; Adipogenesis; Oncostatin M Signaling Pathway; Blood Clotting Cascade; Photodynamic therapy-induced HIF-1 survival signaling; Hypothesized Pathways in Pathogenesis of Cardiovascular Disease; Complement and Coagulation Cascades; TGF-beta Receptor Signaling; Senescence and Autophagy in Cancer,"Dissolution of Fibrin Clot; Platelet degranulation ; ECM proteoglycans; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; BMAL1:CLOCK,NPAS2 activates circadian gene expression",34,High,1
Q13370,"cGMP-inhibited 3',5'-cyclic phosphodiesterase B OS=Homo sapiens OX=9606 GN=PDE3B PE=1 SV=2",0,15.561,3,3,32,1,1112,124.3,5.91,17418,,3,,metabolic process;regulation of biological process;response to stimulus,cytosol;endoplasmic reticulum;Golgi;membrane,catalytic activity;metal ion binding;protein binding,Pf00233,5140,ENSG00000152270.8,PDE3B,11,Purine metabolism; Morphine addiction; cGMP-PKG signaling pathway; Regulation of lipolysis in adipocytes; Glucagon signaling pathway; Progesterone-mediated oocyte maturation; Renin secretion; Insulin signaling pathway; cAMP signaling pathway,Leptin signaling pathway,G alpha (s) signalling events; cGMP effects; PDE3B signalling,28,High,1
Q9NTX7,E3 ubiquitin-protein ligase RNF146 OS=Homo sapiens OX=9606 GN=RNF146 PE=1 SV=1,0,15.559,11,3,10,3,359,38.9,5.33,5026,,3,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,catalytic activity;metal ion binding;protein binding,"Pf00097, Pf02825, Pf13639, Pf13920, Pf13923, Pf14634, Pf15227",81847,ENSG00000118518.15,RNF146,6,,,Regulation of PTEN stability and activity; Ub-specific processing proteases; Degradation of AXIN,12,High,1
P51805,Plexin-A3 OS=Homo sapiens OX=9606 GN=PLXNA3 PE=1 SV=2,0,15.544,2,4,9,1,1871,207.6,7.31,3143,,4,,cell growth;cellular component movement;development;regulation of biological process;response to stimulus,membrane;nucleus,protein binding;receptor activity;signal transducer activity,"Pf01403, Pf01437, Pf01833, Pf08337",55558,,PLXNA3,X,Axon guidance,,SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Sema3A PAK dependent Axon repulsion; CRMPs in Sema3A signaling,7,High,1
O00562,Membrane-associated phosphatidylinositol transfer protein 1 OS=Homo sapiens OX=9606 GN=PITPNM1 PE=1 SV=4,0,15.485,3,3,10,3,1244,134.8,5.95,3891,,3,,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;Golgi;membrane,metal ion binding;protein binding;transporter activity,"Pf02121, Pf02862, Pf08235",9600,ENSG00000110697.12,PITPNM1,11,,,Synthesis of PI,5,High,1
Q92990,Glomulin OS=Homo sapiens OX=9606 GN=GLMN PE=1 SV=2,0,15.444,5,3,14,3,594,68.2,5.33,6935,,3,,cell differentiation;regulation of biological process,cytoplasm,enzyme regulator activity;protein binding,Pf08568,11146,ENSG00000174842.16,GLMN,1,,,Antigen processing: Ubiquitination & Proteasome degradation,4,High,1
Q13595,Transformer-2 protein homolog alpha OS=Homo sapiens OX=9606 GN=TRA2A PE=1 SV=1,0,15.441,12,3,8,3,282,32.7,11.27,4105,,3,,metabolic process,nucleus,RNA binding,"Pf00076, Pf13893, Pf14259",29896,ENSG00000164548.10,TRA2A,7,Spliceosome,,,1,High,1
Q6IS24,Polypeptide N-acetylgalactosaminyltransferase 17 OS=Homo sapiens OX=9606 GN=GALNT17 PE=2 SV=2,0,15.431,7,3,7,3,598,67.7,8.9,2953,,3,,metabolic process,Golgi;membrane,catalytic activity;metal ion binding,"Pf00535, Pf00652, Pf10111, Pf13641",64409,ENSG00000185274.11,WBSCR17; GALNT17,7,Mucin type O-glycan biosynthesis; Metabolic pathways,,O-linked glycosylation of mucins,6,High,1
P62304,Small nuclear ribonucleoprotein E OS=Homo sapiens OX=9606 GN=SNRPE PE=1 SV=1,0,15.426,25,2,44,2,92,10.8,9.44,17140,,2,,cell organization and biogenesis;metabolic process;transport,cytoplasm;cytosol;nucleus;spliceosomal complex,protein binding;RNA binding,Pf01423,6635,ENSG00000182004.12,SNRPE,1,Spliceosome,mRNA Processing,SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; snRNP Assembly; Cleavage of Growing Transcript in the Termination Region,16,High,1
Q9BQ48,"39S ribosomal protein L34, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL34 PE=1 SV=1",0,15.411,25,3,16,3,92,10.2,12.25,7979,,3,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,structural molecule activity,Pf00468,64981,ENSG00000130312.6,MRPL34,19,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
Q9BWU0,Kanadaptin OS=Homo sapiens OX=9606 GN=SLC4A1AP PE=1 SV=1,0,15.411,6,4,22,4,796,88.8,5.19,8619,,4,,,cytoplasm;membrane;nucleus,protein binding;RNA binding,"Pf00035, Pf00498",22950,ENSG00000163798.13,SLC4A1AP,2,,,,0,High,1
Q01433,AMP deaminase 2 OS=Homo sapiens OX=9606 GN=AMPD2 PE=1 SV=2,0,15.41,5,5,10,5,879,100.6,6.93,3506,,5,,metabolic process,cytosol,catalytic activity;metal ion binding;protein binding,Pf00962,271,ENSG00000116337.15,AMPD2,1,Purine metabolism; Metabolic pathways,,Purine salvage,6,High,1
P04156,Major prion protein OS=Homo sapiens OX=9606 GN=PRNP PE=1 SV=1,0,15.399,15,2,23,2,253,27.6,9,7212,,2,,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cell surface;cytoplasm;cytosol;endoplasmic reticulum;Golgi;membrane;nucleus,metal ion binding;protein binding;receptor activity;signal transducer activity,"Pf00377, Pf11587",5621,ENSG00000171867.16,PRNP,20,Prion diseases,Copper homeostasis,NCAM1 interactions,6,High,1
P52292,Importin subunit alpha-1 OS=Homo sapiens OX=9606 GN=KPNA2 PE=1 SV=1,0,15.397,10,4,10,4,529,57.8,5.4,3703,,4,,metabolic process;regulation of biological process;transport,cytoplasm;cytosol;membrane;nucleus,protein binding;RNA binding;transporter activity,"Pf00514, Pf01749, Pf13513, Pf13646",3838,ENSG00000182481.8,KPNA2,17,Influenza A,,ISG15 antiviral mechanism;  NS1 Mediated Effects on Host Pathways; Sensing of DNA Double Strand Breaks,15,High,1
Q15438,Cytohesin-1 OS=Homo sapiens OX=9606 GN=CYTH1 PE=1 SV=1,0,15.394,10,4,12,2,398,46.4,5.54,4825,,4,,regulation of biological process;transport,cytoplasm;cytosol;membrane,protein binding,"Pf00169, Pf01369, Pf15413",9267,ENSG00000108669.16,CYTH1,17,Endocytosis; Phospholipase D signaling pathway,,Intra-Golgi traffic,6,High,1
A4D1P6,WD repeat-containing protein 91 OS=Homo sapiens OX=9606 GN=WDR91 PE=1 SV=2,0,15.387,7,5,16,5,747,83.3,6.58,4825,0,5,1,metabolic process;regulation of biological process;transport,cytosol;endosome;membrane,enzyme regulator activity;protein binding,Pf00400,29062,ENSG00000105875.13,WDR91,7,,,,0,High,1
O95967,EGF-containing fibulin-like extracellular matrix protein 2 OS=Homo sapiens OX=9606 GN=EFEMP2 PE=1 SV=3,0,15.376,9,2,6,2,443,49.4,4.94,3155,,2,,cell organization and biogenesis,extracellular,metal ion binding;protein binding;structural molecule activity,"Pf07645, Pf12662, Pf12947, Pf14670",30008,ENSG00000172638.12,EFEMP2,11,,,Molecules associated with elastic fibres,3,High,1
Q9HCP0,Casein kinase I isoform gamma-1 OS=Homo sapiens OX=9606 GN=CSNK1G1 PE=1 SV=1,0,15.355,9,4,36,2,422,48.5,9.01,14343,,4,,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf07714, Pf12605",53944,ENSG00000169118.17,CSNK1G1,15,Hedgehog signaling pathway,Wnt Signaling Pathway Netpath,,2,High,1
P51790,H(+)/Cl(-) exchange transporter 3 OS=Homo sapiens OX=9606 GN=CLCN3 PE=1 SV=2,0,15.324,6,5,17,3,818,90.9,6.28,8719,,5,,cellular homeostasis;regulation of biological process;transport,cell surface;endosome;Golgi;membrane,nucleotide binding;protein binding;transporter activity,"Pf00571, Pf00654",1182,ENSG00000109572.13,CLCN3,4,,,Stimuli-sensing channels,3,High,1
Q9BUK6,Protein misato homolog 1 OS=Homo sapiens OX=9606 GN=MSTO1 PE=1 SV=1,0,15.305,6,3,13,3,570,61.8,6.11,6320,,3,,cell organization and biogenesis,cytoplasm;membrane;mitochondrion,catalytic activity,"Pf00091, Pf10644, Pf14881",55154,ENSG00000125459.14,MSTO1,1,,,,0,High,1
Q6ZV29,Patatin-like phospholipase domain-containing protein 7 OS=Homo sapiens OX=9606 GN=PNPLA7 PE=1 SV=4,0,15.3,4,4,9,4,1317,145.6,7.74,3403,,4,,,,,,,,,,,,,0,High,1
Q13613,Myotubularin-related protein 1 OS=Homo sapiens OX=9606 GN=MTMR1 PE=1 SV=4,0,15.292,7,4,11,4,665,74.6,7.14,5087,,4,,metabolic process,cytoplasm;cytosol;membrane,catalytic activity;protein binding,"Pf02893, Pf06602",8776,ENSG00000063601.16,MTMR1,X,Phosphatidylinositol signaling system; Metabolic pathways; Inositol phosphate metabolism,,Synthesis of PIPs at the plasma membrane,8,High,1
Q9P0J7,E3 ubiquitin-protein ligase KCMF1 OS=Homo sapiens OX=9606 GN=KCMF1 PE=1 SV=2,0,15.29,14,2,2,2,381,41.9,5.66,1155,,2,,transport,extracellular,catalytic activity;metal ion binding,"Pf00569, Pf05605, Pf14571",56888,ENSG00000176407.17,KCMF1,2,,,Neutrophil degranulation,3,High,1
Q6P161,"39S ribosomal protein L54, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL54 PE=1 SV=1",0,15.242,26,2,13,2,138,15.8,9.6,6608,,2,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,RNA binding,Pf08561,116541,ENSG00000183617.4,MRPL54,19,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
Q9Y485,DmX-like protein 1 OS=Homo sapiens OX=9606 GN=DMXL1 PE=1 SV=3,0,15.22,2,4,9,4,3027,337.6,6.34,2842,,4,,cell organization and biogenesis;cellular homeostasis,,protein binding,"Pf00400, Pf12234",1657,ENSG00000172869.14,DMXL1,5,,,,0,High,1
P39748,Flap endonuclease 1 OS=Homo sapiens OX=9606 GN=FEN1 PE=1 SV=1,0,15.217,13,4,12,3,380,42.6,8.62,5057,,4,,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,membrane;mitochondrion;nucleus,catalytic activity;DNA binding;metal ion binding;protein binding,"Pf00752, Pf00867, Pf01367",2237,ENSG00000168496.3,FEN1,11,Base excision repair; Non-homologous end-joining; DNA replication,,POLB-Dependent Long Patch Base Excision Repair; Early Phase of HIV Life Cycle; Removal of the Flap Intermediate; HDR through MMEJ (alt-NHEJ); PCNA-Dependent Long Patch Base Excision Repair; Removal of the Flap Intermediate from the C-strand,32,High,1
Q96RT1,Erbin OS=Homo sapiens OX=9606 GN=ERBIN PE=1 SV=2,0,15.213,3,4,15,4,1412,158.2,5.5,5314,,4,,cell growth;cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;membrane;nucleus,protein binding;structural molecule activity,"Pf00595, Pf12799, Pf13180, Pf13855",55914,ENSG00000112851.14,ERBB2IP; ERBIN,5,NOD-like receptor signaling pathway,Nucleotide-binding Oligomerization Domain (NOD) pathway; NLR Proteins; Pathways Affected in Adenoid Cystic Carcinoma,Downregulation of ERBB2 signaling,8,High,1
O95759,TBC1 domain family member 8 OS=Homo sapiens OX=9606 GN=TBC1D8 PE=1 SV=3,0,15.193,7,4,14,4,1140,130.8,5.52,4696,4.53,3,1,regulation of biological process;transport,membrane,enzyme regulator activity;protein binding,"Pf00566, Pf02893",11138,ENSG00000204634.12,TBC1D8,2,,Cell Cycle,,1,High,1
P48960,CD97 antigen OS=Homo sapiens OX=9606 GN=CD97 PE=1 SV=4,0,15.181,4,2,6,2,835,91.8,6.87,3248,,2,,cell communication;cellular component movement;defense response;regulation of biological process;response to stimulus;transport,cell surface;extracellular;membrane,metal ion binding;protein binding;receptor activity;signal transducer activity,"Pf00001, Pf00002, Pf00008, Pf01825, Pf04893, Pf06247, Pf07645, Pf12662, Pf12730, Pf12947",976,ENSG00000123146.19,CD97; ADGRE5,19,,"GPCRs, Class B Secretin-like",Neutrophil degranulation; Class B/2 (Secretin family receptors),8,High,1
Q9Y279,V-set and immunoglobulin domain-containing protein 4 OS=Homo sapiens OX=9606 GN=VSIG4 PE=1 SV=1,0,15.181,15,4,9,4,399,44,6.35,2924,,4,,defense response;metabolic process;regulation of biological process;response to stimulus,membrane,protein binding,"Pf00047, Pf07679, Pf13895, Pf13927",11326,ENSG00000155659.14,VSIG4,X,Complement and coagulation cascades,,,1,High,1
Q13895,Bystin OS=Homo sapiens OX=9606 GN=BYSL PE=1 SV=3,0,15.18,8,4,14,4,437,49.6,8.12,5919,,4,,cell differentiation;cell proliferation;metabolic process,cytoplasm;cytosol;membrane;nucleus,protein binding;RNA binding,Pf05291,705,ENSG00000112578.9,BYSL,6,,,Major pathway of rRNA processing in the nucleolus and cytosol,4,High,1
Q9H497,Torsin-3A OS=Homo sapiens OX=9606 GN=TOR3A PE=1 SV=1,0,15.157,9,3,7,3,397,46.2,6.01,2180,,3,,,cytoplasm;endoplasmic reticulum;organelle lumen,catalytic activity;nucleotide binding,"Pf06309, Pf13401",64222,ENSG00000186283.13,TOR3A,1,,,,0,High,1
Q9BV38,WD repeat-containing protein 18 OS=Homo sapiens OX=9606 GN=WDR18 PE=1 SV=2,0,15.155,13,3,10,3,432,47.4,6.7,4312,,3,,development;metabolic process,cytoplasm;nucleus,protein binding,"Pf00400, Pf14077",57418,ENSG00000065268.10,WDR18,19,,,Major pathway of rRNA processing in the nucleolus and cytosol,4,High,1
P62308,Small nuclear ribonucleoprotein G OS=Homo sapiens OX=9606 GN=SNRPG PE=1 SV=1,0,15.148,26,3,20,3,76,8.5,8.88,8261,,3,,cell organization and biogenesis;metabolic process;transport,cytoplasm;cytosol;nucleus;spliceosomal complex,protein binding;RNA binding;structural molecule activity,"Pf01423, Pf03122",6637,ENSG00000143977.13,SNRPG,2,Spliceosome,mRNA Processing,SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; snRNP Assembly; Cleavage of Growing Transcript in the Termination Region,16,High,1
Q9NRW3,DNA dC->dU-editing enzyme APOBEC-3C OS=Homo sapiens OX=9606 GN=APOBEC3C PE=1 SV=2,0,15.145,13,2,10,2,190,22.8,7.59,4225,0,2,1,defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,catalytic activity;metal ion binding;protein binding;RNA binding,"Pf05240, Pf08210",27350,ENSG00000244509.3,APOBEC3C,22,,,Formation of the Editosome,4,High,1
P61966,AP-1 complex subunit sigma-1A OS=Homo sapiens OX=9606 GN=AP1S1 PE=1 SV=1,0,15.138,19,3,11,1,158,18.7,5.73,5427,,3,,regulation of biological process;response to stimulus;transport,cytosol;Golgi;membrane,transporter activity,Pf01217,1174,ENSG00000106367.13,AP1S1,7,Lysosome,,Nef mediated downregulation of MHC class I complex cell surface expression; MHC class II antigen presentation; Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis,17,High,1
Q9UJ83,2-hydroxyacyl-CoA lyase 1 OS=Homo sapiens OX=9606 GN=HACL1 PE=1 SV=2,0,15.136,7,3,16,3,578,63.7,7.36,5242,,3,,cell organization and biogenesis;metabolic process,organelle lumen,catalytic activity;metal ion binding;protein binding,"Pf00205, Pf02552, Pf02775, Pf02776",26061,ENSG00000131373.14,HACL1,3,Peroxisome,,Alpha-oxidation of phytanate,6,High,1
Q8N5H7,SH2 domain-containing protein 3C OS=Homo sapiens OX=9606 GN=SH2D3C PE=1 SV=1,0,15.12,5,3,5,3,860,94.4,8.07,2818,,3,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;membrane,protein binding,"Pf00017, Pf00617",10044,ENSG00000095370.19,SH2D3C,9,,,,0,High,1
P20839,Inosine-5'-monophosphate dehydrogenase 1 OS=Homo sapiens OX=9606 GN=IMPDH1 PE=1 SV=2,0,15.116,8,5,51,3,514,55.4,6.9,20332,0,5,1,cell proliferation;metabolic process;transport,cytoplasm;cytosol;extracellular;nucleus;organelle lumen,catalytic activity;DNA binding;metal ion binding;RNA binding,"Pf00478, Pf00571, Pf01070, Pf03060, Pf05690",3614,,IMPDH1,7,Drug metabolism - other enzymes; Purine metabolism; Metabolic pathways,Nucleotide Metabolism,Neutrophil degranulation; Purine ribonucleoside monophosphate biosynthesis,11,High,1
Q9Y274,"Type 2 lactosamine alpha-2,3-sialyltransferase OS=Homo sapiens OX=9606 GN=ST3GAL6 PE=1 SV=1",0,15.098,10,4,16,4,331,38.2,9,6496,,4,,metabolic process;response to stimulus,Golgi;membrane,catalytic activity,Pf00777,10402,ENSG00000064225.12,ST3GAL6,3,Metabolic pathways; Glycosphingolipid biosynthesis - lacto and neolacto series,,Sialic acid metabolism; Pre-NOTCH Processing in Golgi; Keratan sulfate biosynthesis,17,High,1
Q6ZMJ2,Scavenger receptor class A member 5 OS=Homo sapiens OX=9606 GN=SCARA5 PE=2 SV=1,0,15.091,8,3,9,3,495,54,7.09,3206,,3,,cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport,cell surface;membrane,receptor activity,"Pf00530, Pf01391",286133,ENSG00000168079.16,SCARA5,8,,,Scavenging by Class A Receptors,3,High,1
Q92569,Phosphatidylinositol 3-kinase regulatory subunit gamma OS=Homo sapiens OX=9606 GN=PIK3R3 PE=1 SV=2,0,15.077,16,4,14,2,461,54.4,6.02,6330,,4,,metabolic process;regulation of biological process;response to stimulus,cytosol,catalytic activity;enzyme regulator activity;protein binding,Pf00017,8503,ENSG00000117461.14,PIK3R3,1,cGMP-PKG signaling pathway; ErbB signaling pathway; Proteoglycans in cancer; Hepatitis C; Platinum drug resistance; Pancreatic cancer; Breast cancer; Toxoplasmosis; Small cell lung cancer; Cholinergic synapse; Osteoclast differentiation; Rap1 signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Leukocyte transendothelial migration; cAMP signaling pathway; Longevity regulating pathway - multiple species; Neurotrophin signaling pathway; Thyroid hormone signaling pathway; mTOR signaling pathway; Endocrine resistance; Prolactin signaling pathway; Type II diabetes mellitus; Focal adhesion; Fc epsilon RI signaling pathway; PI3K-Akt signaling pathway; HIF-1 signaling pathway; Oxytocin signaling pathway; EGFR tyrosine kinase inhibitor resistance; Bacterial invasion of epithelial cells; Regulation of lipolysis in adipocytes; T cell receptor signaling pathway; VEGF signaling pathway; Phosphatidylinositol signaling system; Carbohydrate digestion and absorption; Axon guidance; Viral carcinogenesis; Chronic myeloid leukemia; Pathways in cancer; Choline metabolism in cancer; Ras signaling pathway; Hepatitis B; Non-small cell lung cancer; Renal cell carcinoma; Non-alcoholic fatty liver disease (NAFLD); Influenza A; Phospholipase D signaling pathway; Natural killer cell mediated cytotoxicity; Jak-STAT signaling pathway; Inflammatory mediator regulation of TRP channels; Platelet activation; TNF signaling pathway; Acute myeloid leukemia; Adrenergic signaling in cardiomyocytes; Regulation of actin cytoskeleton; Signaling pathways regulating pluripotency of stem cells; FoxO signaling pathway; Colorectal cancer; Apoptosis; Toll-like receptor signaling pathway; Longevity regulating pathway; Amoebiasis; B cell receptor signaling pathway; Glioma; Aldosterone-regulated sodium reabsorption; Chemokine signaling pathway; Central carbon metabolism in cancer; Endometrial cancer; HTLV-I infection; Measles; Insulin resistance; Chagas disease (American trypanosomiasis); Epstein-Barr virus infection; Prostate cancer; AMPK signaling pathway; Fc gamma R-mediated phagocytosis; Insulin signaling pathway; Progesterone-mediated oocyte maturation; Melanoma; Sphingolipid signaling pathway; Estrogen signaling pathway,AMP-activated Protein Kinase (AMPK) Signaling; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Angiopoietin Like Protein 8 Regulatory Pathway; Chemokine signaling pathway; Leptin Insulin Overlap; Microglia Pathogen Phagocytosis Pathway; Insulin Signaling; Regulation of Actin Cytoskeleton; DNA Damage Response (only ATM dependent); Toll-like receptor signaling pathway,"G alpha (12/13) signalling events; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Interleukin-7 signaling; G beta:gamma signalling through PI3Kgamma; Interleukin receptor SHC signaling; Gastrin-CREB signalling pathway via PKC and MAPK; Regulation of signaling by CBL; GPVI-mediated activation cascade; CD28 dependent PI3K/Akt signaling; RET signaling; Synthesis of PIPs at the plasma membrane; Signaling by SCF-KIT; Constitutive Signaling by Aberrant PI3K in Cancer",133,High,1
Q13829,BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 OS=Homo sapiens OX=9606 GN=TNFAIP1 PE=1 SV=1,0,15.049,11,4,19,1,316,36.2,8.03,7402,,4,,cell death;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;endosome;nucleus,catalytic activity;protein binding,Pf02214,7126,ENSG00000109079.9,TNFAIP1,17,,,,0,High,1
P41214,Eukaryotic translation initiation factor 2D OS=Homo sapiens OX=9606 GN=EIF2D PE=1 SV=3,0,15.01,13,4,5,4,584,64.7,7.65,2125,,4,,cell organization and biogenesis;metabolic process;transport,cytoplasm;cytosol,protein binding;receptor activity;RNA binding,"Pf01253, Pf01472",1939,ENSG00000143486.15,EIF2D,1,,,,0,High,1
P26572,"Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase OS=Homo sapiens OX=9606 GN=MGAT1 PE=1 SV=2",0,15.009,8,3,13,3,445,50.8,9.16,7129,,3,,metabolic process,Golgi;membrane,catalytic activity;metal ion binding,Pf03071,4245,ENSG00000131446.16,MGAT1,5,N-Glycan biosynthesis; Metabolic pathways,,N-glycan trimming and elongation in the cis-Golgi,7,High,1
Q9UJX3,Anaphase-promoting complex subunit 7 OS=Homo sapiens OX=9606 GN=ANAPC7 PE=1 SV=4,0,15.005,9,4,6,4,599,66.8,5.64,2869,,4,,cell division;metabolic process;regulation of biological process,cytosol;nucleus,protein binding,"Pf00515, Pf07719, Pf09674, Pf13414, Pf13432",51434,ENSG00000196510.12,ANAPC7,12,Cell cycle; Progesterone-mediated oocyte maturation; Oocyte meiosis; Ubiquitin mediated proteolysis; HTLV-I infection,,APC/C:Cdc20 mediated degradation of Cyclin B; Inactivation of APC/C via direct inhibition of the APC/C complex; Autodegradation of Cdh1 by Cdh1:APC/C; APC-Cdc20 mediated degradation of Nek2A; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Antigen processing: Ubiquitination & Proteasome degradation; Phosphorylation of the APC/C; APC/C:Cdc20 mediated degradation of Securin; Separation of Sister Chromatids; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Senescence-Associated Secretory Phenotype (SASP),37,High,1
Q99717,Mothers against decapentaplegic homolog 5 OS=Homo sapiens OX=9606 GN=SMAD5 PE=1 SV=1,0,14.95,10,4,12,4,465,52.2,7.71,4352,0,4,1,cell differentiation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,DNA binding;metal ion binding;protein binding;signal transducer activity,"Pf03165, Pf03166, Pf10401",4090,ENSG00000113658.16,SMAD5,5,TGF-beta signaling pathway; Signaling pathways regulating pluripotency of stem cells,Differentiation of white and brown adipocyte; BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation; BMP Signaling Pathway in Eyelid Development; ESC Pluripotency Pathways; TGF-beta Receptor Signaling,Signaling by BMP,10,High,1
P55061,Bax inhibitor 1 OS=Homo sapiens OX=9606 GN=TMBIM6 PE=1 SV=2,0,14.949,9,2,19,2,237,26.5,8.54,7712,,2,,cell death;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;endoplasmic reticulum;membrane;nucleus,enzyme regulator activity;protein binding,Pf01027,7009,ENSG00000139644.12,TMBIM6,12,,,,0,High,1
P01591,Immunoglobulin J chain OS=Homo sapiens OX=9606 GN=JCHAIN PE=1 SV=4,0,14.946,17,3,43,3,159,18.1,5.24,19829,,3,,cellular component movement;defense response;regulation of biological process;response to stimulus;transport,extracellular,DNA binding;protein binding,Pf15097,3512,ENSG00000132465.10,IGJ; JCHAIN,4,,,Scavenging of heme from plasma; Cell surface interactions at the vascular wall,5,High,1
P10109,"Adrenodoxin, mitochondrial OS=Homo sapiens OX=9606 GN=FDX1 PE=1 SV=1",0,14.943,14,3,20,3,184,19.4,5.83,10347,,3,,metabolic process;response to stimulus;transport,mitochondrion;organelle lumen,metal ion binding,Pf00111,2230,ENSG00000137714.2,FDX1,11,,,"Endogenous sterols; Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR); Electron transport from NADPH to Ferredoxin; Pregnenolone biosynthesis",15,High,1
Q9H6U8,"Alpha-1,2-mannosyltransferase ALG9 OS=Homo sapiens OX=9606 GN=ALG9 PE=1 SV=2",0,14.93,5,2,8,2,611,69.8,8.68,4777,,2,,metabolic process,endoplasmic reticulum;membrane,catalytic activity,Pf03901,79796,ENSG00000086848.14,ALG9,11,Metabolic pathways; N-Glycan biosynthesis,,"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG9 causes ALG9-CDG (CDG-1l)",10,High,1
P01706,Immunoglobulin lambda variable 2-11 OS=Homo sapiens OX=9606 GN=IGLV2-11 PE=1 SV=2,0,14.92,16,2,44,1,119,12.6,7.24,16367,,2,,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity,"Pf07679, Pf07686",28816,ENSG00000211668.2,IGLV2-11,22,,,FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis,26,High,1
Q8NFX7,Syntaxin-binding protein 6 OS=Homo sapiens OX=9606 GN=STXBP6 PE=1 SV=2,0,14.914,18,3,18,3,210,23.5,9.04,7304,,3,,regulation of biological process;transport,cytoplasm;membrane,protein binding,"Pf00957, Pf15277",29091,ENSG00000168952.15,STXBP6,14,,,,0,High,1
Q8WTX7,Cytosolic arginine sensor for mTORC1 subunit 1 OS=Homo sapiens OX=9606 GN=CASTOR1 PE=1 SV=1,0,14.903,8,2,9,1,329,36.3,5.19,3254,,2,,regulation of biological process,cytoplasm;cytosol,protein binding,Pf13840,652968,ENSG00000239282.7,GATSL3; CASTOR1,22,,,,0,High,1
O75582,Ribosomal protein S6 kinase alpha-5 OS=Homo sapiens OX=9606 GN=RPS6KA5 PE=1 SV=1,0,14.886,3,2,12,1,802,89.8,7.11,5400,,2,,cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;membrane;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf00433, Pf01636, Pf06293, Pf07714, Pf14531",9252,ENSG00000100784.10,RPS6KA5,14,Adrenergic signaling in cardiomyocytes; TNF signaling pathway; MAPK signaling pathway; MicroRNAs in cancer; Bladder cancer; Circadian entrainment; Neurotrophin signaling pathway,Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Structural Pathway of Interleukin 1 (IL-1); Bladder Cancer; MAPK Signaling Pathway; ERK Pathway in Huntington's Disease; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; p38 MAPK Signaling Pathway; EGF/EGFR Signaling Pathway; Insulin Signaling; Interferon type I signaling pathways; Serotonin Receptor 4/6/7 and NR3C Signaling,CREB phosphorylation; ERK/MAPK targets; Recycling pathway of L1; CD209 (DC-SIGN) signaling; NCAM signaling for neurite out-growth; Activated TLR4 signalling,57,High,1
Q8NEN9,PDZ domain-containing protein 8 OS=Homo sapiens OX=9606 GN=PDZD8 PE=1 SV=1,0,14.884,5,4,11,4,1154,128.5,6.09,3194,,4,,cell organization and biogenesis;regulation of biological process;response to stimulus,membrane,metal ion binding;protein binding,"Pf00130, Pf00595, Pf13180",118987,ENSG00000165650.11,PDZD8,10,,,,0,High,1
Q9BPX7,UPF0415 protein C7orf25 OS=Homo sapiens OX=9606 GN=C7orf25 PE=1 SV=1,0,14.87,10,4,15,4,421,46.4,6.42,6304,,4,,,,protein binding,Pf07000,79020,ENSG00000136197.12,C7orf25,7,,,,0,High,1
Q9H0W8,Protein SMG9 OS=Homo sapiens OX=9606 GN=SMG9 PE=1 SV=1,0,14.869,14,4,7,4,520,57.6,7.01,2877,0,3,1,metabolic process,cytosol,protein binding,,56006,ENSG00000105771.13,SMG9,19,,,Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC),3,High,1
Q9Y3D5,"28S ribosomal protein S18c, mitochondrial OS=Homo sapiens OX=9606 GN=MRPS18C PE=1 SV=1",0,14.858,13,2,17,2,142,15.8,9.55,6200,,2,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,structural molecule activity,Pf01084,51023,ENSG00000163319.10,MRPS18C,4,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
Q86YH6,Decaprenyl-diphosphate synthase subunit 2 OS=Homo sapiens OX=9606 GN=PDSS2 PE=1 SV=2,0,14.835,6,2,15,2,399,44.1,8.24,6895,,2,,cell organization and biogenesis;metabolic process,cytosol;mitochondrion;organelle lumen,catalytic activity;protein binding,Pf00348,57107,ENSG00000164494.11,PDSS2,6,Terpenoid backbone biosynthesis,,Ubiquinol biosynthesis,5,High,1
Q8TCC3,"39S ribosomal protein L30, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL30 PE=1 SV=1",0,14.831,17,2,9,2,161,18.5,9.99,4374,,2,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,structural molecule activity,Pf00327,51263,ENSG00000185414.19,MRPL30,2,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
A5D6W6,Fat storage-inducing transmembrane protein 1 OS=Homo sapiens OX=9606 GN=FITM1 PE=2 SV=1,0,14.828,9,2,21,2,292,32.2,9.79,3434,15.38,1,1,cell organization and biogenesis;metabolic process;regulation of biological process,endoplasmic reticulum;membrane,,Pf10261,161247,ENSG00000139914.6,FITM1,14,,,Lipid particle organization,3,High,1
O60828,Polyglutamine-binding protein 1 OS=Homo sapiens OX=9606 GN=PQBP1 PE=1 SV=1,0,14.826,19,3,12,3,265,30.5,6.33,5325,,3,,cell division;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus;spliceosomal complex,DNA binding;protein binding,Pf00397,10084,ENSG00000102103.15,PQBP1,X,Spliceosome,,mRNA Splicing - Major Pathway,5,High,1
Q00653,Nuclear factor NF-kappa-B p100 subunit OS=Homo sapiens OX=9606 GN=NFKB2 PE=1 SV=4,0,14.818,8,3,7,3,900,96.7,6.25,2683,,3,,cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,DNA binding;protein binding,"Pf00023, Pf00554, Pf12796, Pf13606, Pf13637, Pf13857",4791,ENSG00000077150.18,NFKB2,10,Pathways in cancer; Osteoclast differentiation; Legionellosis; MAPK signaling pathway; NF-kappa B signaling pathway; Breast cancer; Epstein-Barr virus infection; Viral carcinogenesis; HTLV-I infection,Regulation of toll-like receptor signaling pathway; Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway; Neural Crest Differentiation; TNF alpha Signaling Pathway; EBV LMP1 signaling; Photodynamic therapy-induced NF-kB survival signaling; Toll-like Receptor Signaling; ApoE and miR-146 in inflammation and atherosclerosis; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways; Toll-like receptor signaling pathway,IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); Interleukin-1 processing; TRAF6 mediated NF-kB activation; PKMTs methylate histone lysines; NIK-->noncanonical NF-kB signaling; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; RIP-mediated NFkB activation via ZBP1; Activated TLR4 signalling; DEx/H-box helicases activate type I IFN and inflammatory cytokines production ; Dectin-1 mediated noncanonical NF-kB signaling; IkBA variant leads to EDA-ID,66,High,1
P51159,Ras-related protein Rab-27A OS=Homo sapiens OX=9606 GN=RAB27A PE=1 SV=3,0,14.812,18,4,71,1,221,24.9,5.22,34454,0,4,2,cell differentiation;cell organization and biogenesis;coagulation;regulation of biological process;response to stimulus;transport,cytosol;endosome;extracellular;Golgi;membrane;organelle lumen;vacuole,catalytic activity;nucleotide binding;protein binding,"Pf00009, Pf00025, Pf00071, Pf04670, Pf08477",5873,ENSG00000069974.15,RAB27A,15,,Deregulation of Rab and Rab Effector Genes in Bladder Cancer,Insulin processing; Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation,13,High,1
P31994-2,Isoform IIB2 of Low affinity immunoglobulin gamma Fc region receptor II-b OS=Homo sapiens OX=9606 GN=FCGR2B,0,14.812,20,4,9,1,291,31.9,6.44,2441,2.4,3,2,cell differentiation;cell organization and biogenesis;defense response;regulation of biological process;response to stimulus;transport,membrane,protein binding;receptor activity;signal transducer activity,"Pf00047, Pf07679, Pf07686, Pf13895, Pf13927",2213,ENSG00000072694.20,FCGR2B,1,,,,0,High,1
Q96BH1,E3 ubiquitin-protein ligase RNF25 OS=Homo sapiens OX=9606 GN=RNF25 PE=1 SV=1,0,14.803,7,2,11,2,459,51.2,6.54,4543,,2,,metabolic process;regulation of biological process,cytosol;nucleus,catalytic activity;metal ion binding;protein binding,"Pf05773, Pf13639, Pf13923",64320,ENSG00000163481.7,RNF25,2,,Tryptophan metabolism,Antigen processing: Ubiquitination & Proteasome degradation,5,High,1
Q495W5,"Alpha-(1,3)-fucosyltransferase 11 OS=Homo sapiens OX=9606 GN=FUT11 PE=1 SV=1",0,14.802,10,3,11,3,492,55.8,5.94,3242,0,2,1,metabolic process,Golgi;membrane,catalytic activity;protein binding,Pf00852,170384,ENSG00000196968.10,FUT11,10,,,,0,High,1
Q8WXA9-2,Isoform 2 of Splicing regulatory glutamine/lysine-rich protein 1 OS=Homo sapiens OX=9606 GN=SREK1,0,14.788,12,4,8,4,624,71.6,10.2,1935,4.05,3,1,metabolic process;regulation of biological process,spliceosomal complex,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",140890,ENSG00000153914.15,SREK1,5,,mRNA Processing,,1,High,1
Q8N3P4,Vacuolar protein sorting-associated protein 8 homolog OS=Homo sapiens OX=9606 GN=VPS8 PE=1 SV=3,0,14.787,4,5,21,5,1428,161.7,5.64,5898,,5,,cell organization and biogenesis;transport,endosome,metal ion binding;protein binding,"Pf12816, Pf13639",23355,ENSG00000156931.15,VPS8,3,,,,0,High,1
Q9NXU5,ADP-ribosylation factor-like protein 15 OS=Homo sapiens OX=9606 GN=ARL15 PE=1 SV=1,0,14.768,17,3,22,3,204,22.9,5.63,9835,,3,,regulation of biological process;response to stimulus,,catalytic activity;nucleotide binding;protein binding;signal transducer activity,"Pf00025, Pf00503, Pf08477, Pf09439, Pf13671",54622,ENSG00000185305.10,ARL15,5,,,,0,High,1
Q9BVQ7,Spermatogenesis-associated protein 5-like protein 1 OS=Homo sapiens OX=9606 GN=SPATA5L1 PE=1 SV=2,0,14.763,5,4,20,4,753,80.7,8.09,9297,,4,,metabolic process;response to stimulus,cytoplasm,catalytic activity;nucleotide binding,"Pf00004, Pf05496, Pf05673, Pf06068, Pf07724, Pf07726, Pf07728, Pf13173, Pf13191, Pf13207, Pf13401, Pf13671",79029,ENSG00000171763.18,SPATA5L1,15,,,,0,High,1
Q9P2B4,CTTNBP2 N-terminal-like protein OS=Homo sapiens OX=9606 GN=CTTNBP2NL PE=1 SV=2,0,14.743,6,4,8,4,639,70.1,8.06,2895,,4,,metabolic process;regulation of biological process,cytoplasm;cytoskeleton,catalytic activity;motor activity;protein binding,"Pf01576, Pf02463, Pf04111, Pf04156, Pf05557, Pf07888, Pf09727, Pf09728, Pf12128, Pf13514",55917,ENSG00000143079.14,CTTNBP2NL,1,,,,0,High,1
P62068,Ubiquitin carboxyl-terminal hydrolase 46 OS=Homo sapiens OX=9606 GN=USP46 PE=1 SV=1,0,14.737,10,3,8,3,366,42.4,6.83,4108,,3,,defense response;metabolic process;regulation of biological process;response to stimulus,,catalytic activity;metal ion binding;protein binding,"Pf00443, Pf13423",64854,ENSG00000109189.12,USP46,4,,,,0,High,1
Q8N0U8,Vitamin K epoxide reductase complex subunit 1-like protein 1 OS=Homo sapiens OX=9606 GN=VKORC1L1 PE=1 SV=2,0,14.725,16,3,39,3,176,19.8,9.13,22756,,3,,metabolic process;response to stimulus,endoplasmic reticulum;membrane,catalytic activity,Pf07884,154807,ENSG00000196715.5,VKORC1L1,7,Ubiquinone and other terpenoid-quinone biosynthesis,,Metabolism of vitamin K,5,High,1
A1IGU5,Rho guanine nucleotide exchange factor 37 OS=Homo sapiens OX=9606 GN=ARHGEF37 PE=2 SV=2,0,14.719,9,4,5,4,675,76.2,6.93,1511,,4,,regulation of biological process;response to stimulus,cytoplasm,protein binding,"Pf00018, Pf00621, Pf03114, Pf07653, Pf08239, Pf14604",389337,ENSG00000183111.11,ARHGEF37,5,,,G alpha (12/13) signalling events; NRAGE signals death through JNK; Signalling by NGF; Rho GTPase cycle,11,High,1
Q9NWW5,Ceroid-lipofuscinosis neuronal protein 6 OS=Homo sapiens OX=9606 GN=CLN6 PE=1 SV=1,0,14.716,11,2,6,2,311,35.9,8.87,2207,,2,,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process,endoplasmic reticulum;membrane;organelle lumen,protein binding,Pf15156,54982,ENSG00000128973.12,CLN6,15,,,,0,High,1
Q7Z4G1,COMM domain-containing protein 6 OS=Homo sapiens OX=9606 GN=COMMD6 PE=1 SV=1,0,14.715,52,3,30,3,85,9.6,6,14832,,3,,metabolic process;regulation of biological process,cytoplasm;nucleus,protein binding,Pf07258,170622,ENSG00000188243.12,COMMD6,13,,,Neddylation,3,High,1
Q9Y5R8,Trafficking protein particle complex subunit 1 OS=Homo sapiens OX=9606 GN=TRAPPC1 PE=1 SV=1,0,14.705,19,3,19,3,145,16.8,9.16,10179,,3,,cell organization and biogenesis;transport,cytosol;endoplasmic reticulum;extracellular;Golgi;membrane;organelle lumen,,Pf04099,58485,ENSG00000170043.11,TRAPPC1,17,,,Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; COPII (Coat Protein 2) Mediated Vesicle Transport,13,High,1
Q9UBX1,Cathepsin F OS=Homo sapiens OX=9606 GN=CTSF PE=1 SV=1,0,14.704,8,4,37,4,484,53.3,8.22,16285,0,3,1,metabolic process,organelle lumen;vacuole,catalytic activity,"Pf00112, Pf03051, Pf08246",8722,ENSG00000174080.10,CTSF,11,Lysosome; Apoptosis,,MHC class II antigen presentation,5,High,1
P0C7P0,"CDGSH iron-sulfur domain-containing protein 3, mitochondrial OS=Homo sapiens OX=9606 GN=CISD3 PE=1 SV=1",0,14.697,9,2,44,2,127,14.2,10.55,24623,,2,,,mitochondrion,metal ion binding,Pf09360,284106,ENSG00000274768.2; ENSG00000277972.1,CISD3,17; CHR_HSCHR17_7_CTG4,,,,0,High,1
Q6P1S2,Protein C3orf33 OS=Homo sapiens OX=9606 GN=C3orf33 PE=1 SV=2,0,14.657,16,4,19,4,294,33.7,9.85,6129,,4,,regulation of biological process,extracellular;membrane,,,285315,ENSG00000174928.15,C3orf33,3,,,,0,High,1
P62266,40S ribosomal protein S23 OS=Homo sapiens OX=9606 GN=RPS23 PE=1 SV=3,0,14.639,17,3,61,3,143,15.8,10.49,29425,0,3,1,cell organization and biogenesis;metabolic process;transport,cytosol;membrane;ribosome,protein binding;RNA binding;structural molecule activity,Pf00164,6228,ENSG00000186468.12,RPS23,5,Ribosome,Cytoplasmic Ribosomal Proteins,"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane",38,High,1
Q92620,Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 OS=Homo sapiens OX=9606 GN=DHX38 PE=1 SV=2,0,14.619,5,4,12,4,1227,140.4,6.54,4515,,4,,metabolic process;transport,cytoplasm;membrane;nucleus;spliceosomal complex,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00270, Pf00271, Pf04408, Pf07717, Pf13191, Pf13401, Pf15440",9785,ENSG00000140829.11,DHX38,16,Spliceosome,mRNA Processing,Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway,13,High,1
Q12899,Tripartite motif-containing protein 26 OS=Homo sapiens OX=9606 GN=TRIM26 PE=1 SV=1,0,14.581,10,4,23,4,539,62.1,5.03,11139,,4,,defense response;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;DNA binding;metal ion binding;protein binding,"Pf00097, Pf00622, Pf00643, Pf05290, Pf13445, Pf13639, Pf13765, Pf13920, Pf13923, Pf14634, Pf14835, Pf15227",7726,ENSG00000230230.7; ENSG00000231002.7; ENSG00000228881.7; ENSG00000137313.15; ENSG00000231641.9; ENSG00000234127.8; ENSG00000226060.7; ENSG00000234046.7,TRIM26,6; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_APD_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1,,,Interferon gamma signaling,4,High,1
Q13951,Core-binding factor subunit beta OS=Homo sapiens OX=9606 GN=CBFB PE=1 SV=2,0,14.581,17,3,18,3,182,21.5,6.6,9124,,3,,cell differentiation;metabolic process;regulation of biological process,membrane;nucleus,DNA binding;protein binding,Pf02312,865,ENSG00000067955.13,CBFB,16,,Dual hijack model of Vif in HIV infection,RUNX3 regulates WNT signaling; Regulation of RUNX2 expression and activity; RUNX3 Regulates Immune Response and Cell Migration; RUNX1 regulates transcription of genes involved in WNT signaling; RUNX3 regulates RUNX1-mediated transcription; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RUNX3 regulates p14-ARF; RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs); RUNX2 regulates osteoblast differentiation; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RUNX1 regulates transcription of genes involved in differentiation of keratinocytes; RUNX1 regulates transcription of genes involved in interleukin signaling; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; RUNX1 regulates transcription of genes involved in BCR signaling; RUNX2 regulates chondrocyte maturation; RUNX1 regulates expression of components of tight junctions; Regulation of RUNX3 expression and activity; RUNX2 regulates genes involved in differentiation of myeloid cells; Regulation of RUNX1 Expression and Activity; RUNX2 regulates genes involved in cell migration; RUNX1 regulates estrogen receptor mediated transcription,30,High,1
Q8NCC3,Group XV phospholipase A2 OS=Homo sapiens OX=9606 GN=PLA2G15 PE=1 SV=2,0,14.572,8,3,8,3,412,46.6,6.73,2750,,3,,metabolic process,extracellular;membrane;mitochondrion;vacuole,catalytic activity,"Pf02450, Pf12697",23659,ENSG00000103066.12,PLA2G15,16,Glycerophospholipid metabolism; Lysosome,,Hydrolysis of LPC,7,High,1
Q9P0S2,"Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=COX16 PE=1 SV=1",0,14.566,29,3,14,3,106,12.3,9.5,7125,,3,,,membrane;mitochondrion,,Pf14138,51241,ENSG00000133983.14,COX16,14,,,TP53 Regulates Metabolic Genes; Respiratory electron transport,9,High,1
O95685,Protein phosphatase 1 regulatory subunit 3D OS=Homo sapiens OX=9606 GN=PPP1R3D PE=1 SV=1,0,14.566,15,3,12,3,299,32.5,8.07,4154,,3,,metabolic process;regulation of biological process,,catalytic activity;protein binding,Pf03370,5509,ENSG00000132825.6,PPP1R3D,20,Insulin signaling pathway; Insulin resistance,,,2,High,1
Q9NQ66,"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 OS=Homo sapiens OX=9606 GN=PLCB1 PE=1 SV=1",0,14.555,6,5,10,5,1216,138.5,6.23,2437,0,4,1,cell differentiation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,catalytic activity;enzyme regulator activity;metal ion binding;protein binding;signal transducer activity,"Pf00168, Pf00387, Pf00388, Pf08703, Pf09279",23236,ENSG00000182621.17,PLCB1,20,Phospholipase D signaling pathway; Inositol phosphate metabolism; Chemokine signaling pathway; Serotonergic synapse; Insulin secretion; Gastric acid secretion; Endocrine and other factor-regulated calcium reabsorption; Long-term depression; Renin secretion; Thyroid hormone synthesis; Cholinergic synapse; Vascular smooth muscle contraction; Adrenergic signaling in cardiomyocytes; GnRH signaling pathway; Dopaminergic synapse; Long-term potentiation; Retrograde endocannabinoid signaling; Oxytocin signaling pathway; Wnt signaling pathway; Platelet activation; Amoebiasis; Gap junction; Salivary secretion; Huntington's disease; Pancreatic secretion; Calcium signaling pathway; Chagas disease (American trypanosomiasis); Thyroid hormone signaling pathway; Sphingolipid signaling pathway; cGMP-PKG signaling pathway; Glucagon signaling pathway; Estrogen signaling pathway; Pathways in cancer; Aldosterone synthesis and secretion; Glutamatergic synapse; AGE-RAGE signaling pathway in diabetic complications; Metabolic pathways; Circadian entrainment; Alzheimer's disease; NOD-like receptor signaling pathway; Phosphatidylinositol signaling system; Inflammatory mediator regulation of TRP channels; Rap1 signaling pathway; Melanogenesis; African trypanosomiasis,AMP-activated Protein Kinase (AMPK) Signaling; Human Thyroid Stimulating Hormone (TSH) signaling pathway; Alzheimers Disease; Endothelin Pathways; Signal Transduction of S1P Receptor; Cell-type Dependent Selectivity of CCK2R Signaling; Chemokine signaling pathway; GPR40 PATHWAY,PLC beta mediated events; Acetylcholine regulates insulin secretion; Ca2+ pathway; Presynaptic function of Kainate receptors; G beta:gamma signalling through PLC beta; Synthesis of IP3 and IP4 in the cytosol; Gastrin-CREB signalling pathway via PKC and MAPK; Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion,79,High,1
Q9NZP8,Complement C1r subcomponent-like protein OS=Homo sapiens OX=9606 GN=C1RL PE=1 SV=2,0,14.552,6,2,13,2,487,53.5,7.2,7751,,2,,defense response;metabolic process;regulation of biological process;response to stimulus,extracellular,catalytic activity,"Pf00089, Pf00431",51279,ENSG00000139178.10,C1RL,12,,,,0,High,1
Q9UBS8,E3 ubiquitin-protein ligase RNF14 OS=Homo sapiens OX=9606 GN=RNF14 PE=1 SV=1,0,14.526,7,3,19,3,474,53.8,4.75,7237,0,3,1,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;protein binding,"Pf00097, Pf01485, Pf05773, Pf13639",9604,ENSG00000013561.17,RNF14,5,,Androgen receptor signaling pathway,Antigen processing: Ubiquitination & Proteasome degradation,5,High,1
Q8TF05,Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Homo sapiens OX=9606 GN=PPP4R1 PE=1 SV=1,0,14.501,5,4,14,4,950,106.9,4.77,7618,,4,,metabolic process;regulation of biological process;response to stimulus,,catalytic activity;enzyme regulator activity;protein binding,,9989,ENSG00000154845.15,PPP4R1,18,,,,0,High,1
Q9HCJ1,Progressive ankylosis protein homolog OS=Homo sapiens OX=9606 GN=ANKH PE=1 SV=2,0,14.498,10,4,11,4,492,54.2,7.88,4026,,4,,regulation of biological process;response to stimulus;transport,membrane,transporter activity,Pf07260,56172,ENSG00000154122.12,ANKH,5,,,Miscellaneous transport and binding events,2,High,1
Q5SRH9-4,Isoform 4 of Tetratricopeptide repeat protein 39A OS=Homo sapiens OX=9606 GN=TTC39A,0,14.496,7,3,12,3,581,66.6,7.28,3658,4.29,2,1,,,,"Pf10300, Pf13432",22996,ENSG00000085831.15,TTC39A,1,,,,0,High,1
Q8IYS1,Peptidase M20 domain-containing protein 2 OS=Homo sapiens OX=9606 GN=PM20D2 PE=1 SV=2,0,14.491,12,4,14,4,436,47.7,5.85,4708,,4,,metabolic process;regulation of biological process,,catalytic activity,"Pf01546, Pf07687",135293,ENSG00000146281.5,PM20D2,6,,,,0,High,1
Q9Y4R8,Telomere length regulation protein TEL2 homolog OS=Homo sapiens OX=9606 GN=TELO2 PE=1 SV=2,0,14.489,5,4,10,3,837,91.7,5.76,3732,,4,,regulation of biological process,chromosome;cytoplasm;cytosol;membrane;nucleus,protein binding;structural molecule activity,Pf10193,9894,ENSG00000100726.14,TELO2,16,mTOR signaling pathway; Fanconi anemia pathway,,,2,High,1
Q13868,Exosome complex component RRP4 OS=Homo sapiens OX=9606 GN=EXOSC2 PE=1 SV=2,0,14.477,15,3,8,3,293,32.8,7.5,2452,,3,,metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;protein binding;RNA binding,Pf14382,23404,ENSG00000130713.15,EXOSC2,9,RNA degradation,,"Major pathway of rRNA processing in the nucleolus and cytosol; mRNA decay by 3' to 5' exoribonuclease; ATF4 activates genes; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; KSRP (KHSRP) binds and destabilizes mRNA",15,High,1
O75150,E3 ubiquitin-protein ligase BRE1B OS=Homo sapiens OX=9606 GN=RNF40 PE=1 SV=5,0,14.475,3,3,24,2,1001,113.6,6.29,7283,,3,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytosol;membrane;nucleus,catalytic activity;metal ion binding;protein binding;RNA binding,"Pf00097, Pf13639, Pf13920, Pf13923, Pf14634",9810,ENSG00000103549.21,RNF40,16,,ATM Signaling Network in Development and Disease,,1,High,1
Q8N4N3,Kelch-like protein 36 OS=Homo sapiens OX=9606 GN=KLHL36 PE=1 SV=1,0,14.467,6,3,8,3,616,69.9,6.24,3121,,3,,metabolic process,,catalytic activity;protein binding,"Pf00651, Pf01344, Pf07646, Pf07707, Pf13415, Pf13418, Pf13964",79786,ENSG00000135686.12,KLHL36,16,,,,0,High,1
Q6PD62,RNA polymerase-associated protein CTR9 homolog OS=Homo sapiens OX=9606 GN=CTR9 PE=1 SV=1,0,14.462,5,4,5,4,1173,133.4,6.77,1872,,4,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,nucleus,protein binding,"Pf08424, Pf13414, Pf13424, Pf13432, Pf14559",9646,ENSG00000198730.7,CTR9,11,,Endoderm Differentiation,E3 ubiquitin ligases ubiquitinate target proteins; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events,10,High,1
P15260,Interferon gamma receptor 1 OS=Homo sapiens OX=9606 GN=IFNGR1 PE=1 SV=1,0,14.455,13,4,7,4,489,54.4,4.91,2241,,4,,defense response;regulation of biological process;response to stimulus,endoplasmic reticulum;membrane,protein binding;receptor activity;signal transducer activity,"Pf01108, Pf07140, Pf09294",3459,ENSG00000027697.13,IFNGR1,6,Natural killer cell mediated cytotoxicity; HIF-1 signaling pathway; Th1 and Th2 cell differentiation; Measles; Toxoplasmosis; Leishmaniasis; Osteoclast differentiation; Influenza A; Chagas disease (American trypanosomiasis); Salmonella infection; Tuberculosis; Cytokine-cytokine receptor interaction; Inflammatory bowel disease (IBD); Herpes simplex infection; Jak-STAT signaling pathway,Type II interferon signaling (IFNG),Regulation of IFNG signaling,21,High,1
Q8N7H5,RNA polymerase II-associated factor 1 homolog OS=Homo sapiens OX=9606 GN=PAF1 PE=1 SV=2,0,14.454,8,3,14,3,531,59.9,4.63,5841,,3,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;membrane;nucleus,protein binding,Pf03985,54623,ENSG00000006712.14,PAF1,19,,Endoderm Differentiation,E3 ubiquitin ligases ubiquitinate target proteins; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events,10,High,1
Q9P270,SLAIN motif-containing protein 2 OS=Homo sapiens OX=9606 GN=SLAIN2 PE=1 SV=2,0,14.451,9,4,12,4,581,62.5,9.45,3961,,4,,cell organization and biogenesis;regulation of biological process,cytoplasm;cytoskeleton;cytosol,protein binding,Pf15301,57606,ENSG00000109171.14,SLAIN2,4,,,,0,High,1
O94811,Tubulin polymerization-promoting protein OS=Homo sapiens OX=9606 GN=TPPP PE=1 SV=1,0,14.45,14,3,37,3,219,23.7,9.44,13655,0,3,1,cell organization and biogenesis;regulation of biological process,cytoplasm;cytoskeleton;cytosol;mitochondrion;nucleus,protein binding,Pf05517,11076,ENSG00000171368.11,TPPP,5,,Regulation of Microtubule Cytoskeleton; Glial Cell Differentiation; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,,3,High,1
Q5VW38,Protein GPR107 OS=Homo sapiens OX=9606 GN=GPR107 PE=1 SV=1,0,14.449,4,2,26,2,600,66.9,7.24,9258,,2,,transport,endosome;Golgi;membrane,protein binding,Pf06814,57720,ENSG00000148358.19,GPR107,9,,,,0,High,1
O60927,E3 ubiquitin-protein ligase PPP1R11 OS=Homo sapiens OX=9606 GN=PPP1R11 PE=1 SV=1,0,14.437,12,1,6,1,126,13.9,7.01,2707,,1,,regulation of biological process,cytoplasm;nucleus,enzyme regulator activity;protein binding,Pf07491,6992,ENSG00000237829.6; ENSG00000227720.6; ENSG00000236560.6; ENSG00000233314.6; ENSG00000206501.8; ENSG00000237403.6; ENSG00000234058.6; ENSG00000204619.7,PPP1R11,6; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_APD_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_COX_CTG1,,,,0,High,1
Q9BVM4,Gamma-glutamylaminecyclotransferase OS=Homo sapiens OX=9606 GN=GGACT PE=1 SV=2,0,14.436,29,3,16,3,153,17.3,6.87,8484,,3,,metabolic process,,catalytic activity;protein binding,Pf06094,87769,ENSG00000134864.10,GGACT,13,,,,0,High,1
O15118,NPC intracellular cholesterol transporter 1 OS=Homo sapiens OX=9606 GN=NPC1 PE=1 SV=2,0,14.417,3,3,6,3,1278,142.1,5.36,2575,,3,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;endosome;extracellular;Golgi;membrane;vacuole,protein binding;receptor activity;signal transducer activity;transporter activity,"Pf00873, Pf02460, Pf03176, Pf12349",4864,ENSG00000141458.12,NPC1,18,Lysosome,Irinotecan Pathway,LDL clearance,6,High,1
Q9NX05,Constitutive coactivator of PPAR-gamma-like protein 2 OS=Homo sapiens OX=9606 GN=FAM120C PE=1 SV=3,0,14.411,4,3,5,3,1096,120.5,9.03,2281,,3,,,nucleus,RNA binding,,54954,,FAM120C,X,,,,0,High,1
Q9Y2B9,cAMP-dependent protein kinase inhibitor gamma OS=Homo sapiens OX=9606 GN=PKIG PE=2 SV=1,0,14.384,22,2,11,2,76,7.9,4.25,7257,,2,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,catalytic activity;enzyme regulator activity;protein binding,Pf02827,11142,ENSG00000168734.13,PKIG,20,,Myometrial Relaxation and Contraction Pathways; Calcium Regulation in the Cardiac Cell,,2,High,1
P15169,Carboxypeptidase N catalytic chain OS=Homo sapiens OX=9606 GN=CPN1 PE=1 SV=1,0,14.364,10,4,13,4,458,52.3,7.34,3829,3.67,4,1,metabolic process;regulation of biological process;response to stimulus,extracellular;Golgi,catalytic activity;metal ion binding,"Pf00246, Pf10994, Pf13620, Pf13715",1369,ENSG00000120054.11,CPN1,10,,Steroid Biosynthesis,Insulin processing; Regulation of Complement cascade,8,High,1
Q7Z7K0,COX assembly mitochondrial protein homolog OS=Homo sapiens OX=9606 GN=CMC1 PE=1 SV=1,0,14.36,18,2,35,2,106,12.5,8.63,16399,,2,,,mitochondrion,metal ion binding,Pf08583,152100,ENSG00000187118.12,CMC1,3,,,,0,High,1
Q9UIG0,Tyrosine-protein kinase BAZ1B OS=Homo sapiens OX=9606 GN=BAZ1B PE=1 SV=2,0,14.352,2,3,8,3,1483,170.8,8.48,4482,,3,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00439, Pf00628, Pf10537, Pf15613, Pf15614",9031,ENSG00000009954.10,BAZ1B,7,,,Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; B-WICH complex positively regulates rRNA expression,8,High,1
Q9BZE4,Nucleolar GTP-binding protein 1 OS=Homo sapiens OX=9606 GN=GTPBP4 PE=1 SV=3,0,14.349,10,4,8,4,634,73.9,9.5,1888,,4,,cell differentiation;regulation of biological process;response to stimulus,cytoplasm;cytosol;Golgi;membrane;nucleus,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00009, Pf01926, Pf02421, Pf06858, Pf08155, Pf08477",23560,ENSG00000107937.18,GTPBP4,10,Ribosome biogenesis in eukaryotes,,,1,High,1
Q13488,V-type proton ATPase 116 kDa subunit a isoform 3 OS=Homo sapiens OX=9606 GN=TCIRG1 PE=1 SV=3,0,14.337,5,3,16,3,830,92.9,7.12,6428,,3,,cell communication;cell organization and biogenesis;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,membrane;mitochondrion,catalytic activity;protein binding;transporter activity,Pf01496,10312,ENSG00000110719.9,TCIRG1,11,Lysosome; Collecting duct acid secretion; Vibrio cholerae infection; Tuberculosis; Rheumatoid arthritis; Epithelial cell signaling in Helicobacter pylori infection; Oxidative phosphorylation; Synaptic vesicle cycle; Metabolic pathways; Phagosome,TYROBP Causal Network,"Transferrin endocytosis and recycling; ROS, RNS production in phagocytes; Ion channel transport; Insulin receptor recycling; Neutrophil degranulation",23,High,1
Q9NSC5,Homer protein homolog 3 OS=Homo sapiens OX=9606 GN=HOMER3 PE=1 SV=2,0,14.313,12,3,13,2,361,39.8,5.45,4960,,3,,regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane,protein binding,Pf00568,9454,ENSG00000051128.18,HOMER3,19,Glutamatergic synapse; FoxO signaling pathway,,Neurexins and neuroligins,5,High,1
Q9Y673,Dolichyl-phosphate beta-glucosyltransferase OS=Homo sapiens OX=9606 GN=ALG5 PE=1 SV=1,0,14.307,14,4,13,4,324,36.9,9.28,4478,,4,,metabolic process,endoplasmic reticulum;membrane,catalytic activity,"Pf00535, Pf10111, Pf13641",29880,ENSG00000120697.8,ALG5,13,Metabolic pathways; N-Glycan biosynthesis,,Synthesis of dolichyl-phosphate-glucose,8,High,1
Q9GZU8,PSME3-interacting protein OS=Homo sapiens OX=9606 GN=FAM192A PE=1 SV=1,0,14.305,13,3,13,3,254,28.9,5.45,6475,,3,,,nucleus,protein binding,Pf10187,80011,ENSG00000172775.16,FAM192A,16,,,,0,High,1
Q5W111,SPRY domain-containing protein 7 OS=Homo sapiens OX=9606 GN=SPRYD7 PE=1 SV=2,0,14.287,13,2,15,2,196,21.7,6.7,7659,,2,,,,protein binding,Pf00622,57213,ENSG00000123178.14,SPRYD7,13,,,,0,High,1
P25205,DNA replication licensing factor MCM3 OS=Homo sapiens OX=9606 GN=MCM3 PE=1 SV=3,0,14.279,4,3,11,3,808,90.9,5.77,7071,,3,,metabolic process,cytoplasm;membrane;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding,"Pf00493, Pf01078, Pf07728, Pf14551",4172,ENSG00000112118.18,MCM3,6,DNA replication; Cell cycle,Cell Cycle; Retinoblastoma (RB) in Cancer; G1 to S cell cycle control; DNA Replication,M/G1 Transition; Assembly of the pre-replicative complex; Unwinding of DNA; Regulation of DNA replication; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Orc1 removal from chromatin; Removal of licensing factors from origins,26,High,1
Q9C0I1,Myotubularin-related protein 12 OS=Homo sapiens OX=9606 GN=MTMR12 PE=1 SV=2,0,14.267,7,4,14,4,747,86.1,6.62,4713,,4,,metabolic process;regulation of biological process;transport,cytoplasm;cytosol,enzyme regulator activity;protein binding,"Pf06602, Pf12578",54545,ENSG00000150712.10,MTMR12,5,,,Synthesis of PIPs at the early endosome membrane,5,High,1
O75695,Protein XRP2 OS=Homo sapiens OX=9606 GN=RP2 PE=1 SV=4,0,14.255,10,5,14,5,350,39.6,5.12,5735,,5,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;Golgi;membrane,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding,"Pf00334, Pf07986",6102,ENSG00000102218.5,RP2,X,,,Trafficking of myristoylated proteins to the cilium,4,High,1
Q9H1A4,Anaphase-promoting complex subunit 1 OS=Homo sapiens OX=9606 GN=ANAPC1 PE=1 SV=1,0,14.24,2,3,5,3,1944,216.4,6.3,1656,,3,,cell division;metabolic process;regulation of biological process,cytosol;nucleus,,"Pf01851, Pf12859",64682,ENSG00000153107.11,ANAPC1,2,Progesterone-mediated oocyte maturation; Oocyte meiosis; Cell cycle; HTLV-I infection; Ubiquitin mediated proteolysis,,APC/C:Cdc20 mediated degradation of Cyclin B; Inactivation of APC/C via direct inhibition of the APC/C complex; Autodegradation of Cdh1 by Cdh1:APC/C; APC-Cdc20 mediated degradation of Nek2A; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Antigen processing: Ubiquitination & Proteasome degradation; Phosphorylation of the APC/C; APC/C:Cdc20 mediated degradation of Securin; Separation of Sister Chromatids; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Senescence-Associated Secretory Phenotype (SASP),37,High,1
Q8IXM2,Chromatin complexes subunit BAP18 OS=Homo sapiens OX=9606 GN=BAP18 PE=1 SV=1,0,14.232,26,3,11,3,172,17.9,7.33,4578,,3,,cell organization and biogenesis,cytosol;nucleus,DNA binding;protein binding,Pf00249,124944; 100529209,ENSG00000258315.5,C17orf49; RNASEK-C17orf49,17,,,,0,High,1
Q86WR0,Coiled-coil domain-containing protein 25 OS=Homo sapiens OX=9606 GN=CCDC25 PE=1 SV=2,0,14.228,27,6,9,6,208,24.5,6.8,2405,0,6,1,,,protein binding,Pf05670,55246,ENSG00000147419.17,CCDC25,8,,,,0,High,1
P83876,Thioredoxin-like protein 4A OS=Homo sapiens OX=9606 GN=TXNL4A PE=1 SV=1,0,14.228,31,4,18,4,142,16.8,5.85,5431,,4,,cell division;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process,cytosol;membrane;nucleus;spliceosomal complex,protein binding,"Pf00085, Pf02966",10907,ENSG00000141759.14,TXNL4A,18,Spliceosome,mRNA Processing,mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway,7,High,1
P08962,CD63 antigen OS=Homo sapiens OX=9606 GN=CD63 PE=1 SV=2,0,14.223,4,1,54,1,238,25.6,7.81,27345,,1,,cell differentiation;cellular component movement;regulation of biological process;response to stimulus;transport,cell surface;endosome;extracellular;membrane;organelle lumen;vacuole,protein binding,Pf00335,967,ENSG00000135404.11,CD63,12,Proteoglycans in cancer; Lysosome,,Platelet degranulation ; Neutrophil degranulation,9,High,1
B7ZBB8,Protein phosphatase 1 regulatory subunit 3G OS=Homo sapiens OX=9606 GN=PPP1R3G PE=1 SV=1,0,14.22,12,3,21,3,358,38,4.93,9011,,3,,,,protein binding,Pf03370,648791,ENSG00000219607.3,PPP1R3G,6,,,,0,High,1
P05106,Integrin beta-3 OS=Homo sapiens OX=9606 GN=ITGB3 PE=1 SV=2,0,14.205,5,3,8,3,788,87,5.24,3332,,3,,cell differentiation;cell growth;cell organization and biogenesis;cellular component movement;coagulation;regulation of biological process;response to stimulus;transport,cell surface;membrane;nucleus,catalytic activity;protein binding;receptor activity;signal transducer activity,"Pf00362, Pf07965, Pf08725",3690,ENSG00000259207.7,ITGB3,17,Proteoglycans in cancer; Rap1 signaling pathway; Arrhythmogenic right ventricular cardiomyopathy (ARVC); PI3K-Akt signaling pathway; Phagosome; Hematopoietic cell lineage; Platelet activation; Regulation of actin cytoskeleton; Osteoclast differentiation; Focal adhesion; Thyroid hormone signaling pathway; Hypertrophic cardiomyopathy (HCM); MicroRNAs in cancer; ECM-receptor interaction; Dilated cardiomyopathy,Osteoclast Signaling; Osteopontin Signaling; Serotonin Transporter Activity; Integrin-mediated Cell Adhesion; Arrhythmogenic Right Ventricular Cardiomyopathy; Primary Focal Segmental Glomerulosclerosis FSGS; Focal Adhesion; Osteoblast Signaling; MFAP5-mediated ovarian cancer cell motility and invasiveness; TGF-beta Signaling Pathway; VEGFA-VEGFR2 Signaling Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Monoamine Transport,Integrin cell surface interactions; Signaling by BRAF and RAF fusions; Signal transduction by L1; PECAM1 interactions; MAP2K and MAPK activation; VEGFA-VEGFR2 Pathway; Molecules associated with elastic fibres; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Syndecan interactions; Signaling by moderate kinase activity BRAF mutants; p130Cas linkage to MAPK signaling for integrins; Platelet degranulation ; ECM proteoglycans; Paradoxical activation of RAF signaling by kinase inactive BRAF; Interleukin-20 family signaling,70,High,1
O75558,Syntaxin-11 OS=Homo sapiens OX=9606 GN=STX11 PE=1 SV=1,0,14.199,15,3,9,3,287,33.2,6.55,2525,,3,,cell organization and biogenesis;transport,Golgi;membrane,protein binding,"Pf00804, Pf05739",8676,ENSG00000135604.9,STX11,6,SNARE interactions in vesicular transport,,,1,High,1
Q86WQ0,Nuclear receptor 2C2-associated protein OS=Homo sapiens OX=9606 GN=NR2C2AP PE=1 SV=1,0,14.195,26,2,9,2,139,15.9,6.16,3276,,2,,metabolic process,nucleus,protein binding,Pf00754,126382,ENSG00000184162.14,NR2C2AP,19,,,Nuclear Receptor transcription pathway,4,High,1
P31327,"Carbamoyl-phosphate synthase [ammonia], mitochondrial OS=Homo sapiens OX=9606 GN=CPS1 PE=1 SV=2",0,14.171,5,6,152,6,1500,164.8,6.74,46551,,6,,cell differentiation;metabolic process;response to stimulus,cytoplasm;membrane;mitochondrion;nucleus;organelle lumen,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00117, Pf00289, Pf00988, Pf02142, Pf02222, Pf02786, Pf02787, Pf07478, Pf13535, Pf15632",1373,ENSG00000021826.14,CPS1,2,"Nitrogen metabolism; Carbon metabolism; Biosynthesis of amino acids; Arginine biosynthesis; Metabolic pathways; Alanine, aspartate and glutamate metabolism",Amino Acid metabolism; Urea cycle and metabolism of amino groups,Urea cycle,12,High,1
Q08188,Protein-glutamine gamma-glutamyltransferase E OS=Homo sapiens OX=9606 GN=TGM3 PE=1 SV=4,0,14.161,9,6,9,6,693,76.6,5.86,2622,,6,,cell differentiation;cell organization and biogenesis;metabolic process,cytoplasm,catalytic activity;metal ion binding,"Pf00868, Pf00927, Pf01841",7053,ENSG00000125780.11,TGM3,20,,,,0,High,1
P48509,CD151 antigen OS=Homo sapiens OX=9606 GN=CD151 PE=1 SV=3,0,14.137,4,2,44,2,253,28.3,7.47,19960,,2,,cell organization and biogenesis;cell proliferation;cellular component movement;regulation of biological process;response to stimulus,cytosol;membrane,protein binding,Pf00335,977,ENSG00000177697.17,CD151,11,,Primary Focal Segmental Glomerulosclerosis FSGS,Assembly of collagen fibrils and other multimeric structures; Type I hemidesmosome assembly,7,High,1
Q9HAU5,Regulator of nonsense transcripts 2 OS=Homo sapiens OX=9606 GN=UPF2 PE=1 SV=1,0,14.134,4,4,15,4,1272,147.7,5.69,5834,,4,,metabolic process;transport,cytoplasm;cytosol;nucleus,DNA binding;protein binding;RNA binding,"Pf02854, Pf04050",26019,ENSG00000151461.19,UPF2,10,RNA transport; mRNA surveillance pathway,,Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC),9,High,1
O60641,Clathrin coat assembly protein AP180 OS=Homo sapiens OX=9606 GN=SNAP91 PE=1 SV=2,0,14.132,4,3,24,1,907,92.4,4.86,12648,,3,,cell organization and biogenesis;regulation of biological process;transport,membrane,protein binding,"Pf01417, Pf07651",9892,ENSG00000065609.14,SNAP91,6,,,Cargo recognition for clathrin-mediated endocytosis,4,High,1
P53778,Mitogen-activated protein kinase 12 OS=Homo sapiens OX=9606 GN=MAPK12 PE=1 SV=3,0,14.126,8,3,80,2,367,41.9,6.39,38967,,3,,cell differentiation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;mitochondrion;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf01636, Pf07714, Pf14531",6300,ENSG00000188130.13,MAPK12,22,Leishmaniasis; Fc epsilon RI signaling pathway; Influenza A; FoxO signaling pathway; Retrograde endocannabinoid signaling; T cell receptor signaling pathway; Pertussis; Epithelial cell signaling in Helicobacter pylori infection; Progesterone-mediated oocyte maturation; Amyotrophic lateral sclerosis (ALS); Shigellosis; Neurotrophin signaling pathway; Sphingolipid signaling pathway; NOD-like receptor signaling pathway; Proteoglycans in cancer; Chagas disease (American trypanosomiasis); AGE-RAGE signaling pathway in diabetic complications; RIG-I-like receptor signaling pathway; Prolactin signaling pathway; Leukocyte transendothelial migration; MAPK signaling pathway; Hepatitis C; Osteoclast differentiation; Salmonella infection; Rap1 signaling pathway; Inflammatory mediator regulation of TRP channels; Platelet activation; TNF signaling pathway; Toxoplasmosis; VEGF signaling pathway; Toll-like receptor signaling pathway; Signaling pathways regulating pluripotency of stem cells; Th1 and Th2 cell differentiation; Tuberculosis; GnRH signaling pathway; Epstein-Barr virus infection; Oocyte meiosis; Dopaminergic synapse; Adrenergic signaling in cardiomyocytes; Endocrine resistance,Regulation of toll-like receptor signaling pathway; Integrin-mediated Cell Adhesion; Parkinsons Disease Pathway; Signal Transduction of S1P Receptor; Focal Adhesion; Rac1/Pak1/p38/MMP-2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; MAPK Signaling Pathway; RIG-I-like Receptor Signaling; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; ESC Pluripotency Pathways; MAPK Cascade; Insulin Signaling; Toll-like receptor signaling pathway,CDO in myogenesis; NOD1/2 Signaling Pathway; DSCAM interactions; p38MAPK events; VEGFA-VEGFR2 Pathway; Activation of PPARGC1A (PGC-1alpha) by phosphorylation,77,High,1
Q9Y5V3,Melanoma-associated antigen D1 OS=Homo sapiens OX=9606 GN=MAGED1 PE=1 SV=3,0,14.1,5,4,10,3,778,86.1,5.83,4506,,4,,regulation of biological process,chromosome;cytoplasm;membrane;nucleus,protein binding,"Pf00874, Pf01454",9500,ENSG00000179222.17,MAGED1,X,Neurotrophin signaling pathway,,Ligand-independent caspase activation via DCC; NRAGE signals death through JNK; Signalling by NGF,11,High,1
Q9NYU1,UDP-glucose:glycoprotein glucosyltransferase 2 OS=Homo sapiens OX=9606 GN=UGGT2 PE=1 SV=4,0,14.1,2,4,30,1,1516,174.6,6.89,9247,,4,,metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;organelle lumen,catalytic activity;protein binding,"Pf01501, Pf06427",55757,ENSG00000102595.19,UGGT2,13,Protein processing in endoplasmic reticulum,,ER Quality Control Compartment (ERQC),7,High,1
Q5T481,RNA-binding protein 20 OS=Homo sapiens OX=9606 GN=RBM20 PE=1 SV=3,0,14.082,4,3,6,3,1227,134.3,5.69,,15.58,,3,metabolic process;regulation of biological process,nucleus,metal ion binding;RNA binding,"Pf13893, Pf14259",282996,,RBM20,10,,,,0,High,1
P40818,Ubiquitin carboxyl-terminal hydrolase 8 OS=Homo sapiens OX=9606 GN=USP8 PE=1 SV=1,0,14.072,4,3,7,3,1118,127.4,8.51,2875,,3,,cell organization and biogenesis;cell proliferation;metabolic process;response to stimulus,cytoplasm;cytosol;endosome;membrane;nucleus,catalytic activity;protein binding,"Pf00443, Pf00581, Pf08969, Pf13423",9101,ENSG00000138592.13,USP8,15,Endocytosis,EGF/EGFR Signaling Pathway,Negative regulation of MET activity; Ub-specific processing proteases; Regulation of FZD by ubiquitination; Downregulation of ERBB2:ERBB3 signaling,16,High,1
Q9H1U9,Solute carrier family 25 member 51 OS=Homo sapiens OX=9606 GN=SLC25A51 PE=2 SV=1,0,14.067,10,3,21,3,297,33.7,9.44,9461,,3,,transport,membrane;mitochondrion,transporter activity,Pf00153,92014,ENSG00000122696.13,SLC25A51,9,,,,0,High,1
O95758-1,Isoform 1 of Polypyrimidine tract-binding protein 3 OS=Homo sapiens OX=9606 GN=PTBP3,0,14.053,9,3,71,1,521,56.5,9.22,28396,,3,,metabolic process;regulation of biological process,nucleus,RNA binding,"Pf00076, Pf13893, Pf14259",9991,,PTBP3,9,,,,0,High,1
Q02763,Angiopoietin-1 receptor OS=Homo sapiens OX=9606 GN=TEK PE=1 SV=2,0,14.044,7,4,8,4,1124,125.7,6.89,2759,,4,,cell communication;cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cell surface;cytoplasm;cytoskeleton;extracellular;membrane,catalytic activity;nucleotide binding;protein binding;receptor activity;signal transducer activity,"Pf00041, Pf00053, Pf00069, Pf07679, Pf07714, Pf07974, Pf10430, Pf12785",7010,ENSG00000120156.20,TEK,9,Rheumatoid arthritis; HIF-1 signaling pathway; Rap1 signaling pathway; Ras signaling pathway; PI3K-Akt signaling pathway,Angiogenesis; Rac1/Pak1/p38/MMP-2 pathway; Wnt Signaling Pathway Netpath; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,Tie2 Signaling; RAF/MAP kinase cascade; Interleukin-20 family signaling,20,High,1
Q9NXC2,Glucose-fructose oxidoreductase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=GFOD1 PE=1 SV=1,0,14.036,8,3,22,3,390,43.1,5.92,9868,,3,,metabolic process,extracellular,catalytic activity;nucleotide binding;protein binding,"Pf01408, Pf01488, Pf02894, Pf03447",54438,ENSG00000145990.10,GFOD1,6,,,,0,High,1
Q9BTV6,Diphthine methyltransferase OS=Homo sapiens OX=9606 GN=DPH7 PE=1 SV=2,0,14.027,11,3,20,2,452,50.5,6.6,11455,,3,,metabolic process,,catalytic activity;protein binding,Pf00400,92715,ENSG00000148399.12,DPH7; WDR85,9,,,Synthesis of diphthamide-EEF2,4,High,1
P31431,Syndecan-4 OS=Homo sapiens OX=9606 GN=SDC4 PE=1 SV=2,0,14.017,14,2,8,2,198,21.6,4.5,4219,,2,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cell surface;extracellular;membrane;organelle lumen,protein binding;receptor activity;signal transducer activity,Pf01034,6385,ENSG00000124145.6,SDC4,20,Proteoglycans in cancer; ECM-receptor interaction; Cell adhesion molecules (CAMs),,"Defective B4GALT7 causes EDS, progeroid type; Retinoid metabolism and transport; Defective EXT2 causes exostoses 2; Syndecan interactions; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Signaling by GPCR; HS-GAG biosynthesis; A tetrasaccharide linker sequence is required for GAG synthesis; Cell surface interactions at the vascular wall; Defective B3GALT6 causes EDSP2 and SEMDJL1; HS-GAG degradation; Defective B3GAT3 causes JDSSDHD",30,High,1
Q16659,Mitogen-activated protein kinase 6 OS=Homo sapiens OX=9606 GN=MAPK6 PE=1 SV=1,0,14.016,2,2,50,1,721,82.6,5.03,22161,,2,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;nucleus,catalytic activity;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf01636, Pf07714, Pf14531",5597,ENSG00000069956.11,MAPK6,15,,Integrin-mediated Cell Adhesion; Signal Transduction of S1P Receptor; Focal Adhesion; MAPK Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; ESC Pluripotency Pathways; Insulin Signaling; Regulation of Actin Cytoskeleton,MAPK6/MAPK4 signaling,11,High,1
Q9H871,E3 ubiquitin-protein transferase RMND5A OS=Homo sapiens OX=9606 GN=RMND5A PE=1 SV=1,0,14.014,9,3,9,3,391,44,6.06,3628,,3,,metabolic process,cytoplasm;nucleus,catalytic activity;protein binding,"Pf10607, Pf13445",64795,ENSG00000153561.12,RMND5A,2,,,,0,High,1
Q96FZ7,Charged multivesicular body protein 6 OS=Homo sapiens OX=9606 GN=CHMP6 PE=1 SV=3,0,14.007,17,3,9,3,201,23.5,5.31,3757,,3,,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;endosome;membrane,protein binding,Pf03357,79643,ENSG00000176108.9,CHMP6,17,Endocytosis,,Budding and maturation of HIV virion; Macroautophagy; Endosomal Sorting Complex Required For Transport (ESCRT),12,High,1
O43292,Glycosylphosphatidylinositol anchor attachment 1 protein OS=Homo sapiens OX=9606 GN=GPAA1 PE=1 SV=3,0,13.97,7,4,11,4,621,67.6,8.06,4625,,4,,cell organization and biogenesis;metabolic process,endoplasmic reticulum;membrane,catalytic activity;protein binding,Pf04114,8733,ENSG00000197858.10,GPAA1,8,Metabolic pathways; Glycosylphosphatidylinositol (GPI)-anchor biosynthesis,,Attachment of GPI anchor to uPAR,6,High,1
Q8IU85,Calcium/calmodulin-dependent protein kinase type 1D OS=Homo sapiens OX=9606 GN=CAMK1D PE=1 SV=1,0,13.95,8,3,19,1,385,42.9,7.21,7805,,3,,defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf07714, Pf14531",57118,ENSG00000183049.12,CAMK1D,10,Aldosterone synthesis and secretion; Oxytocin signaling pathway,,,2,High,1
Q0JRZ9,F-BAR domain only protein 2 OS=Homo sapiens OX=9606 GN=FCHO2 PE=1 SV=2,0,13.945,4,2,9,2,810,88.9,6.86,3530,,2,,cell organization and biogenesis;transport,cytosol;membrane,protein binding,"Pf00611, Pf10291",115548,ENSG00000157107.13,FCHO2,5,,,Cargo recognition for clathrin-mediated endocytosis,4,High,1
Q9Y6X8,Zinc fingers and homeoboxes protein 2 OS=Homo sapiens OX=9606 GN=ZHX2 PE=1 SV=1,0,13.931,4,3,7,2,837,92.3,6.86,3804,,3,,metabolic process;regulation of biological process,nucleus,DNA binding;metal ion binding;protein binding,"Pf00046, Pf05920",22882,ENSG00000178764.7,ZHX2,8,,,,0,High,1
Q86Y07,Serine/threonine-protein kinase VRK2 OS=Homo sapiens OX=9606 GN=VRK2 PE=1 SV=3,0,13.926,6,2,7,2,508,58.1,8.84,2800,,2,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;endoplasmic reticulum;membrane;mitochondrion;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf07714",7444,ENSG00000028116.16,VRK2,2,,,,0,High,1
Q96NB2,Sideroflexin-2 OS=Homo sapiens OX=9606 GN=SFXN2 PE=1 SV=2,0,13.925,17,4,13,4,322,36.2,9.41,4093,,4,,transport,membrane;mitochondrion,transporter activity,Pf03820,118980,ENSG00000156398.12,SFXN2,10,,,,0,High,1
A5PLN9,Trafficking protein particle complex subunit 13 OS=Homo sapiens OX=9606 GN=TRAPPC13 PE=1 SV=2,0,13.916,9,4,25,4,417,46.5,5.6,8424,,4,,,cytosol,protein binding,Pf06159,80006,ENSG00000113597.17,C5orf44; TRAPPC13,5,,,RAB GEFs exchange GTP for GDP on RABs,4,High,1
Q5K4L6,Solute carrier family 27 member 3 OS=Homo sapiens OX=9606 GN=SLC27A3 PE=2 SV=4,0,13.896,6,5,19,4,683,73.5,7.09,6508,,5,,metabolic process,,catalytic activity,"Pf00501, Pf13193",,,,,,,,0,High,1
Q9NPI6,mRNA-decapping enzyme 1A OS=Homo sapiens OX=9606 GN=DCP1A PE=1 SV=3,0,13.887,9,3,5,3,582,63.2,6.25,2005,,3,,metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;nucleus,catalytic activity;enzyme regulator activity;protein binding;RNA binding,"Pf05109, Pf06058",55802,ENSG00000272886.5,DCP1A,3,RNA degradation,TGF-beta Signaling Pathway,,2,High,1
Q6ZMU5,Tripartite motif-containing protein 72 OS=Homo sapiens OX=9606 GN=TRIM72 PE=1 SV=2,0,13.879,8,3,6,3,477,52.7,6.48,3043,,3,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,membrane,catalytic activity;metal ion binding;protein binding,"Pf00097, Pf00622, Pf00643, Pf13445, Pf13639, Pf13923, Pf14634, Pf14835, Pf15227",493829,ENSG00000177238.13,TRIM72,16,,,Smooth Muscle Contraction,2,High,1
O75616,"GTPase Era, mitochondrial OS=Homo sapiens OX=9606 GN=ERAL1 PE=1 SV=2",0,13.865,13,4,16,4,437,48.3,8.84,5573,,4,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytosol;membrane;mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00350, Pf01926, Pf02421, Pf03193, Pf04548, Pf08477, Pf13521",26284,ENSG00000132591.11,ERAL1,17,,Integrated Breast Cancer Pathway,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
O60260,E3 ubiquitin-protein ligase parkin OS=Homo sapiens OX=9606 GN=PRKN PE=1 SV=2,0,13.859,14,4,5,4,465,51.6,7.06,1096,5.16,2,2,cell communication;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;Golgi;mitochondrion;nucleus,catalytic activity;DNA binding;metal ion binding;protein binding,"Pf00240, Pf01485, Pf11976",5071,ENSG00000185345.18,PARK2; PRKN,6,Protein processing in endoplasmic reticulum; Ubiquitin mediated proteolysis; Parkinson's disease,Parkin-Ubiquitin Proteasomal System pathway; Parkinsons Disease Pathway,Josephin domain DUBs; Antigen processing: Ubiquitination & Proteasome degradation; Amyloid fiber formation; Pink/Parkin Mediated Mitophagy,16,High,1
Q9NUI1,"Peroxisomal 2,4-dienoyl-CoA reductase OS=Homo sapiens OX=9606 GN=DECR2 PE=1 SV=1",0,13.835,12,3,8,3,292,30.8,9.22,3639,,3,,metabolic process,membrane,catalytic activity;protein binding,"Pf00106, Pf08659, Pf13561",26063,ENSG00000242612.6; ENSG00000274296.3,DECR2,16; CHR_HSCHR16_CTG2,Peroxisome,,Beta-oxidation of very long chain fatty acids,6,High,1
Q00587,Cdc42 effector protein 1 OS=Homo sapiens OX=9606 GN=CDC42EP1 PE=1 SV=1,0,13.83,7,2,10,2,391,40.3,7.15,5178,,2,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;membrane,enzyme regulator activity;protein binding,Pf00786,11135,ENSG00000128283.6,CDC42EP1,22,,,,0,High,1
P56937,3-keto-steroid reductase OS=Homo sapiens OX=9606 GN=HSD17B7 PE=1 SV=1,0,13.826,14,4,7,4,341,38.2,8.1,2270,,4,,metabolic process,endoplasmic reticulum;membrane,catalytic activity,"Pf00106, Pf03435, Pf08659, Pf13460",51478,ENSG00000132196.13,HSD17B7,1,Ovarian steroidogenesis; Metabolic pathways; Steroid biosynthesis; Steroid hormone biosynthesis,Steroid Biosynthesis,Cholesterol biosynthesis,9,High,1
Q69YL0,Protein NCBP2AS2 OS=Homo sapiens OX=9606 GN=NCBP2AS2 PE=1 SV=1,0,13.823,29,2,19,2,99,10.9,12,6297,,2,,,,,,152217,ENSG00000270170.1,LOC152217; NCBP2-AS2,3,,,,0,High,1
Q86UL3,Glycerol-3-phosphate acyltransferase 4 OS=Homo sapiens OX=9606 GN=GPAT4 PE=1 SV=1,0,13.819,7,4,22,4,456,52,9.19,8133,0,4,1,metabolic process;regulation of biological process;transport,endoplasmic reticulum;membrane,catalytic activity,Pf01553,137964,ENSG00000158669.11,AGPAT6; GPAT4,8,Glycerolipid metabolism; Metabolic pathways; Glycerophospholipid metabolism,,Synthesis of PA,8,High,1
Q6P6C2,RNA demethylase ALKBH5 OS=Homo sapiens OX=9606 GN=ALKBH5 PE=1 SV=2,0,13.776,14,4,9,4,394,44.2,9.09,3431,,4,,cell differentiation;metabolic process;response to stimulus;transport,cytosol;Golgi;nucleus,catalytic activity;metal ion binding;RNA binding,Pf13532,54890,ENSG00000091542.8,ALKBH5,17,,,Reversal of alkylation damage by DNA dioxygenases,3,High,1
Q96ME7,Zinc finger protein 512 OS=Homo sapiens OX=9606 GN=ZNF512 PE=1 SV=2,0,13.762,6,2,19,2,567,64.6,9.76,5829,,2,,metabolic process;regulation of biological process,nucleus,DNA binding;metal ion binding,,84450,ENSG00000243943.9,ZNF512,2,,,,0,High,1
Q8TD22,Sideroflexin-5 OS=Homo sapiens OX=9606 GN=SFXN5 PE=1 SV=1,0,13.747,10,4,10,4,340,37.1,9.33,4531,,4,,transport,membrane;mitochondrion,transporter activity,Pf03820,94097,ENSG00000144040.12,SFXN5,2,,,,0,High,1
P08709,Coagulation factor VII OS=Homo sapiens OX=9606 GN=F7 PE=1 SV=1,0,13.745,12,3,4,3,466,51.6,7.23,1612,,3,,coagulation;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane;organelle lumen,catalytic activity;metal ion binding;protein binding,"Pf00089, Pf00594, Pf09342, Pf12947, Pf14670",2155,ENSG00000057593.13,F7,13,Complement and coagulation cascades,Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism; Blood Clotting Cascade; Complement and Coagulation Cascades,"Extrinsic Pathway of Fibrin Clot Formation; Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Removal of aminoterminal propeptides from gamma-carboxylated proteins; Gamma-carboxylation of protein precursors",18,High,1
Q01658,Protein Dr1 OS=Homo sapiens OX=9606 GN=DR1 PE=1 SV=1,0,13.719,15,2,9,2,176,19.4,4.75,6208,,2,,cell organization and biogenesis;metabolic process;regulation of biological process,nucleus,DNA binding;protein binding,Pf00808,1810,ENSG00000117505.12,DR1,1,,,HATs acetylate histones,3,High,1
Q96AT9,Ribulose-phosphate 3-epimerase OS=Homo sapiens OX=9606 GN=RPE PE=1 SV=1,0,13.708,33,3,8,3,228,24.9,5.58,2176,,3,,metabolic process,cytosol,catalytic activity;metal ion binding;protein binding,"Pf00218, Pf00834, Pf01729",6120,ENSG00000197713.14,RPE,2,Biosynthesis of amino acids; Metabolic pathways; Carbon metabolism; Pentose and glucuronate interconversions; Pentose phosphate pathway,Pentose Phosphate Pathway,Pentose phosphate pathway (hexose monophosphate shunt),9,High,1
Q9NU23,LYR motif-containing protein 2 OS=Homo sapiens OX=9606 GN=LYRM2 PE=1 SV=1,0,13.697,32,3,25,3,88,10.4,10.46,10305,,3,,,mitochondrion,protein binding,"Pf05347, Pf13232",57226,ENSG00000083099.10,LYRM2,6,,,,0,High,1
Q16635,Tafazzin OS=Homo sapiens OX=9606 GN=TAZ PE=1 SV=1,0,13.643,10,2,6,2,292,33.4,8.91,3294,,2,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;mitochondrion;nucleus,catalytic activity,Pf01553,6901,ENSG00000102125.15,TAZ,X,Glycerophospholipid metabolism,,Acyl chain remodeling of CL; Mitochondrial protein import; Metabolism of proteins,8,High,1
Q7Z5G4,Golgin subfamily A member 7 OS=Homo sapiens OX=9606 GN=GOLGA7 PE=1 SV=2,0,13.642,23,3,14,3,137,15.8,7.05,4896,,3,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,extracellular;Golgi;membrane,catalytic activity;protein binding,Pf10256,51125,ENSG00000147533.16,GOLGA7,8,,,Neutrophil degranulation,3,High,1
Q9ULK4,Mediator of RNA polymerase II transcription subunit 23 OS=Homo sapiens OX=9606 GN=MED23 PE=1 SV=2,0,13.637,3,4,11,4,1368,156.4,7.4,4027,,4,,metabolic process;regulation of biological process,nucleus,protein binding,Pf11573,9439,ENSG00000112282.17,MED23,6,,,Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway,9,High,1
P31641,Sodium- and chloride-dependent taurine transporter OS=Homo sapiens OX=9606 GN=SLC6A6 PE=1 SV=2,0,13.636,3,1,26,1,620,69.8,7.39,10866,,1,,metabolic process;transport,membrane,transporter activity,Pf00209,6533,ENSG00000131389.16,SLC6A6,3,,NRF2 pathway,Amino acid transport across the plasma membrane; Na+/Cl- dependent neurotransmitter transporters,7,High,1
P62888,60S ribosomal protein L30 OS=Homo sapiens OX=9606 GN=RPL30 PE=1 SV=2,0,13.628,27,3,14,3,115,12.8,9.63,5537,2.65,2,1,cell organization and biogenesis;defense response;metabolic process;response to stimulus;transport,cytosol;membrane;nucleus;ribosome,protein binding;RNA binding;structural molecule activity,Pf01248,6156,ENSG00000156482.10,RPL30,8,Ribosome,Selenium Metabolism and Selenoproteins; Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,35,High,1
O43759,Synaptogyrin-1 OS=Homo sapiens OX=9606 GN=SYNGR1 PE=1 SV=2,0,13.628,15,3,13,3,233,25.4,4.68,4071,0,3,1,cell organization and biogenesis;regulation of biological process;transport,membrane,protein binding,Pf01284,9145,ENSG00000100321.14,SYNGR1,22,,,Neutrophil degranulation,3,High,1
Q7Z4Q2,HEAT repeat-containing protein 3 OS=Homo sapiens OX=9606 GN=HEATR3 PE=1 SV=2,0,13.625,5,3,19,3,680,74.5,5.11,8109,,3,,transport,,protein binding,Pf13513,55027,ENSG00000155393.12,HEATR3,16,,,,0,High,1
O60678,Protein arginine N-methyltransferase 3 OS=Homo sapiens OX=9606 GN=PRMT3 PE=1 SV=4,0,13.615,8,3,11,3,531,59.9,5.35,4124,,3,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;ribosome,catalytic activity;metal ion binding;protein binding,"Pf06325, Pf08003, Pf08241, Pf08242, Pf12756, Pf12847, Pf13649, Pf13659, Pf13847",10196,ENSG00000185238.12,PRMT3,11,,,,0,High,1
Q9H4K7,Mitochondrial ribosome-associated GTPase 2 OS=Homo sapiens OX=9606 GN=MTG2 PE=1 SV=1,0,13.609,10,4,32,4,406,43.9,9.45,11866,,4,,metabolic process;regulation of biological process,membrane;mitochondrion;organelle lumen;ribosome,catalytic activity;metal ion binding;nucleotide binding,"Pf00025, Pf01018, Pf01926, Pf02421, Pf08438, Pf10662",26164,ENSG00000101181.17,GTPBP5; MTG2,20,,,,0,High,1
P22413,Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 OS=Homo sapiens OX=9606 GN=ENPP1 PE=1 SV=2,0,13.604,7,5,7,5,925,104.9,7.14,2087,,5,,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;extracellular;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding;receptor activity,"Pf01033, Pf01223, Pf01663",5167,ENSG00000197594.11,ENPP1,6,Nicotinate and nicotinamide metabolism; Pyrimidine metabolism; Pantothenate and CoA biosynthesis; Metabolic pathways; Starch and sucrose metabolism; Purine metabolism,Endochondral Ossification; Insulin Signaling,Vitamin B2 (riboflavin) metabolism; Vitamin B5 (pantothenate) metabolism,13,High,1
Q12982,BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 OS=Homo sapiens OX=9606 GN=BNIP2 PE=1 SV=1,0,13.598,6,2,13,2,314,36,4.81,5973,,2,,cell death;regulation of biological process,cytoplasm;cytosol,enzyme regulator activity;metal ion binding;protein binding,"Pf00650, Pf12496, Pf13716",663,ENSG00000140299.11,BNIP2,15,,,CDO in myogenesis,3,High,1
Q7LBR1,Charged multivesicular body protein 1b OS=Homo sapiens OX=9606 GN=CHMP1B PE=1 SV=1,0,13.594,12,3,33,3,199,22.1,8.1,15261,,3,,cell division;cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytosol;endosome;membrane;nucleus,protein binding,Pf03357,57132,ENSG00000255112.2,CHMP1B,18,Endocytosis,,,1,High,1
P13987,CD59 glycoprotein OS=Homo sapiens OX=9606 GN=CD59 PE=1 SV=1,0,13.563,16,2,80,2,128,14.2,6.48,43247,9.35,1,1,cell organization and biogenesis;coagulation;regulation of biological process;response to stimulus;transport,cell surface;extracellular;membrane,protein binding,Pf00021,966,ENSG00000085063.14,CD59,11,Complement and coagulation cascades; Hematopoietic cell lineage,,Regulation of Complement cascade; Neutrophil degranulation; Cargo concentration in the ER; COPII (Coat Protein 2) Mediated Vesicle Transport; COPI-mediated anterograde transport,17,High,1
Q96RU3,Formin-binding protein 1 OS=Homo sapiens OX=9606 GN=FNBP1 PE=1 SV=2,0,13.561,4,3,7,3,617,71.3,5.72,3012,,3,,cell organization and biogenesis;transport,cytoplasm;cytoskeleton;cytosol;membrane;vacuole,protein binding,"Pf00018, Pf00611, Pf07653, Pf08239, Pf13654, Pf14604",23048,ENSG00000187239.16,FNBP1,9,,,Clathrin-mediated endocytosis,3,High,1
Q96GJ1,tRNA (uracil(54)-C(5))-methyltransferase homolog OS=Homo sapiens OX=9606 GN=TRMT2B PE=1 SV=1,0,13.546,5,2,9,2,504,56.4,8.81,3238,,2,,metabolic process,mitochondrion,catalytic activity;protein binding,"Pf05175, Pf05958, Pf06325, Pf08242, Pf12847, Pf13649, Pf13659, Pf13847",79979,ENSG00000188917.14,TRMT2B,X,,,,0,High,1
P34741,Syndecan-2 OS=Homo sapiens OX=9606 GN=SDC2 PE=1 SV=2,0,13.532,12,2,9,2,201,22.1,4.86,4557,,2,,cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cell surface;membrane;organelle lumen,protein binding,Pf01034,6383,ENSG00000169439.11,SDC2,8,Proteoglycans in cancer; Cell adhesion molecules (CAMs); Malaria,miRNA targets in ECM and membrane receptors,"Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Defective B4GALT7 causes EDS, progeroid type; Retinoid metabolism and transport; Defective EXT2 causes exostoses 2; Syndecan interactions; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Signaling by GPCR; HS-GAG biosynthesis; A tetrasaccharide linker sequence is required for GAG synthesis; EPHB-mediated forward signaling; Cell surface interactions at the vascular wall; Defective B3GALT6 causes EDSP2 and SEMDJL1; HS-GAG degradation; Defective B3GAT3 causes JDSSDHD",39,High,1
Q9Y4E6,WD repeat-containing protein 7 OS=Homo sapiens OX=9606 GN=WDR7 PE=1 SV=2,0,13.528,5,4,5,4,1490,163.7,6.92,1897,,4,,cell differentiation,cytoplasm,protein binding,Pf00400,23335,ENSG00000091157.13,WDR7,18,,,,0,High,1
Q9H6W3,Ribosomal oxygenase 1 OS=Homo sapiens OX=9606 GN=RIOX1 PE=1 SV=2,0,13.493,13,4,39,4,641,71,6.46,15871,,4,,cell organization and biogenesis;metabolic process;regulation of biological process,nucleus,catalytic activity;metal ion binding;protein binding,"Pf08007, Pf13621",79697,ENSG00000170468.7,C14orf169; RIOX1,14,,,,0,High,1
Q5VTU8,"ATP synthase subunit epsilon-like protein, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1EP2 PE=1 SV=1",0,13.478,29,3,84,3,51,5.8,10.14,45698,,3,,metabolic process;transport,membrane;mitochondrion,catalytic activity;transporter activity,Pf04627,432369,ENSG00000180389.6,ATP5EP2,13,,,,0,High,1
Q6NW29,RWD domain-containing protein 4 OS=Homo sapiens OX=9606 GN=RWDD4 PE=1 SV=3,0,13.472,18,3,17,3,188,21.2,5.31,7551,0,3,1,,,protein binding,Pf05773,201965,ENSG00000182552.14,RWDD4,4,,,,0,High,1
P09769,Tyrosine-protein kinase Fgr OS=Homo sapiens OX=9606 GN=FGR PE=1 SV=2,0,13.463,5,3,35,1,529,59.4,5.59,20558,,3,,cell differentiation;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;extracellular;membrane;mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding,"Pf00017, Pf00018, Pf00069, Pf07653, Pf07714, Pf14604",2268,ENSG00000000938.12,FGR,1,Epstein-Barr virus infection; Chemokine signaling pathway,Focal Adhesion; Chemokine signaling pathway,FCGR activation; Neutrophil degranulation; Platelet sensitization by LDL,12,High,1
O43236,Septin-4 OS=Homo sapiens OX=9606 GN=SEPTIN4 PE=1 SV=1,0,13.462,5,2,29,2,478,55.1,6.11,14239,,2,,cell death;cell differentiation;cell division;cell organization and biogenesis;regulation of biological process,cytoplasm;cytoskeleton;mitochondrion;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding;structural molecule activity,"Pf00735, Pf03193",5414,ENSG00000108387.14,SEPT4,17,Apoptosis; Apoptosis - multiple species,,,2,High,1
O00754,Lysosomal alpha-mannosidase OS=Homo sapiens OX=9606 GN=MAN2B1 PE=1 SV=3,0,13.46,4,3,7,3,1011,113.7,7.28,2614,,3,,metabolic process;transport,extracellular;organelle lumen;vacuole,catalytic activity;metal ion binding,"Pf01074, Pf07748, Pf09261",4125,ENSG00000104774.12,MAN2B1,19,Lysosome; Other glycan degradation,,Neutrophil degranulation; Lysosomal oligosaccharide catabolism,8,High,1
Q9Y613,FH1/FH2 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FHOD1 PE=1 SV=3,0,13.446,5,5,46,5,1164,126.5,6.39,14999,,5,,regulation of biological process,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,protein binding,Pf02181,29109,ENSG00000135723.13,FHOD1,16,,,,0,High,1
A4D2B0,Metallo-beta-lactamase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=MBLAC1 PE=1 SV=1,0,13.43,23,4,8,4,266,27.2,4.86,2576,,4,,,,catalytic activity;metal ion binding,Pf00753,255374,ENSG00000214309.4,MBLAC1,7,,,,0,High,1
Q8N8A2,Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B OS=Homo sapiens OX=9606 GN=ANKRD44 PE=1 SV=3,0,13.41,5,4,8,3,993,107.5,6.3,2487,,4,,,,protein binding,"Pf00023, Pf12796, Pf13606, Pf13637, Pf13857",91526,ENSG00000065413.18,ANKRD44,2,,,,0,High,1
Q96P63,Serpin B12 OS=Homo sapiens OX=9606 GN=SERPINB12 PE=1 SV=1,0,13.407,7,3,19,2,405,46.2,5.53,7052,,3,,cell differentiation;regulation of biological process;transport,cytoplasm;membrane,enzyme regulator activity;protein binding,Pf00079,89777,ENSG00000166634.6,SERPINB12,18,,,Neutrophil degranulation,3,High,1
Q9H1I8,Activating signal cointegrator 1 complex subunit 2 OS=Homo sapiens OX=9606 GN=ASCC2 PE=1 SV=3,0,13.401,5,3,7,3,757,86.3,5.16,3728,,3,,metabolic process;regulation of biological process,nucleus,protein binding,Pf02845,84164,ENSG00000100325.14,ASCC2,22,,,ALKBH3 mediated reversal of alkylation damage,4,High,1
Q8N1I0,Dedicator of cytokinesis protein 4 OS=Homo sapiens OX=9606 GN=DOCK4 PE=1 SV=3,0,13.399,2,4,16,4,1966,225.1,7.65,7267,,4,,cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytosol;Golgi;membrane,enzyme regulator activity;protein binding,"Pf00018, Pf06920, Pf07653, Pf14429",9732,ENSG00000128512.20,DOCK4,7,Rap1 signaling pathway,,Factors involved in megakaryocyte development and platelet production,3,High,1
Q14566,DNA replication licensing factor MCM6 OS=Homo sapiens OX=9606 GN=MCM6 PE=1 SV=1,0,13.399,5,4,15,4,821,92.8,5.41,4771,,4,,metabolic process,nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding,"Pf00493, Pf01078, Pf07728, Pf14551",4175,ENSG00000076003.4,MCM6,2,Cell cycle; DNA replication,Cell Cycle; Retinoblastoma (RB) in Cancer; G1 to S cell cycle control; DNA Replication,M/G1 Transition; Assembly of the pre-replicative complex; Unwinding of DNA; Regulation of DNA replication; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Orc1 removal from chromatin; Removal of licensing factors from origins,26,High,1
P54840,"Glycogen [starch] synthase, liver OS=Homo sapiens OX=9606 GN=GYS2 PE=1 SV=2",0,13.39,3,2,116,1,703,80.9,6.83,57618,,2,,metabolic process;response to stimulus,cytoplasm;cytoskeleton;cytosol,catalytic activity;protein binding,"Pf00534, Pf05693",2998,ENSG00000111713.2,GYS2,12,Insulin resistance; Glucagon signaling pathway; AMPK signaling pathway; PI3K-Akt signaling pathway; Metabolic pathways; Starch and sucrose metabolism; Insulin signaling pathway,AMP-activated Protein Kinase (AMPK) Signaling; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Insulin Signaling; Glycogen Metabolism,Glycogen storage disease type IV (GBE1); Glycogen storage disease type 0 (liver GYS2); Glycogen synthesis; Myoclonic epilepsy of Lafora,22,High,1
P62273,40S ribosomal protein S29 OS=Homo sapiens OX=9606 GN=RPS29 PE=1 SV=2,0,13.384,20,1,46,1,56,6.7,10.13,21626,,1,,cell organization and biogenesis;metabolic process;transport,cytosol;ribosome,metal ion binding;structural molecule activity,Pf00253,6235,ENSG00000213741.9,RPS29,14,Ribosome,Cytoplasmic Ribosomal Proteins,"Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; Formation of the ternary complex, and subsequently, the 43S complex; L13a-mediated translational silencing of Ceruloplasmin expression; Selenocysteine synthesis; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Translation initiation complex formation; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane",38,High,1
P31995,Low affinity immunoglobulin gamma Fc region receptor II-c OS=Homo sapiens OX=9606 GN=FCGR2C PE=1 SV=1,0,13.339,17,4,10,1,323,35.6,6.9,3250,0,4,1,cell differentiation;cell organization and biogenesis;defense response;regulation of biological process;response to stimulus;transport,cytoplasm;membrane,protein binding;receptor activity;signal transducer activity,"Pf00047, Pf07679, Pf07686, Pf13895, Pf13927",9103; 2213,,FCGR2C; FCGR2B,1,Staphylococcus aureus infection; Osteoclast differentiation; Leishmaniasis; Tuberculosis; Phagosome,,,5,High,1
Q9NSY1,BMP-2-inducible protein kinase OS=Homo sapiens OX=9606 GN=BMP2K PE=1 SV=2,0,13.331,6,4,16,3,1161,129.1,6.51,4151,,4,,metabolic process;regulation of biological process,cytoplasm;nucleus,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding,"Pf00069, Pf07714, Pf15282",55589,ENSG00000138756.17,BMP2K,4,Transcriptional misregulation in cancer,,,1,High,1
Q9NY27,Serine/threonine-protein phosphatase 4 regulatory subunit 2 OS=Homo sapiens OX=9606 GN=PPP4R2 PE=1 SV=3,0,13.31,9,3,9,3,417,46.9,4.54,3850,,3,,metabolic process;regulation of biological process,cytoplasm;cytoskeleton;nucleus,enzyme regulator activity;protein binding,Pf09184,151987,ENSG00000163605.14,PPP4R2,3,,,Processing of DNA double-strand break ends,5,High,1
Q9NPD3,Exosome complex component RRP41 OS=Homo sapiens OX=9606 GN=EXOSC4 PE=1 SV=3,0,13.309,11,2,9,2,245,26.4,6.52,5524,,2,,defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;nucleus,catalytic activity;protein binding;RNA binding,"Pf01138, Pf03725",54512,ENSG00000178896.8,EXOSC4,8,RNA degradation,,"Major pathway of rRNA processing in the nucleolus and cytosol; mRNA decay by 3' to 5' exoribonuclease; ATF4 activates genes; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; KSRP (KHSRP) binds and destabilizes mRNA",15,High,1
P16455,Methylated-DNA--protein-cysteine methyltransferase OS=Homo sapiens OX=9606 GN=MGMT PE=1 SV=1,0,13.308,16,2,12,2,207,21.6,8.1,4247,,2,,cell differentiation;metabolic process;regulation of biological process;response to stimulus,membrane;nucleus,catalytic activity;DNA binding;metal ion binding,"Pf01035, Pf02870",4255,,MGMT,10,,,MGMT-mediated DNA damage reversal,3,High,1
Q5T6F2,Ubiquitin-associated protein 2 OS=Homo sapiens OX=9606 GN=UBAP2 PE=1 SV=1,0,13.307,6,4,5,4,1119,117,7.34,1515,,4,,regulation of biological process,cytoplasm;nucleus,protein binding;RNA binding,"Pf00627, Pf12478, Pf14555",55833,ENSG00000137073.21,UBAP2,9,,,,0,High,1
P48634,Protein PRRC2A OS=Homo sapiens OX=9606 GN=PRRC2A PE=1 SV=3,0,13.288,3,4,16,4,2157,228.7,9.45,5774,,4,,cell differentiation,cytoplasm;membrane;nucleus,protein binding;RNA binding,Pf07001,7916,ENSG00000204469.12,PRRC2A,6,,,,0,High,1
Q66PJ3,ADP-ribosylation factor-like protein 6-interacting protein 4 OS=Homo sapiens OX=9606 GN=ARL6IP4 PE=1 SV=2,0,13.279,7,2,5,2,421,44.9,10.93,2803,,2,,metabolic process,nucleus,protein binding;RNA binding,Pf10500,51329,ENSG00000182196.13,ARL6IP4,12,,,,0,High,1
Q96CC6,Inactive rhomboid protein 1 OS=Homo sapiens OX=9606 GN=RHBDF1 PE=1 SV=2,0,13.261,7,4,15,4,855,97.3,8.44,4075,,4,,cell proliferation;cellular component movement;metabolic process;regulation of biological process;transport,endoplasmic reticulum;Golgi;membrane,catalytic activity;protein binding,"Pf01694, Pf12595",64285,ENSG00000007384.15,RHBDF1,16,,,,0,High,1
O95716,Ras-related protein Rab-3D OS=Homo sapiens OX=9606 GN=RAB3D PE=1 SV=1,0,13.248,19,3,12,1,219,24.3,4.93,3702,,3,,metabolic process;regulation of biological process;response to stimulus;transport,membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf04670, Pf08477",9545,ENSG00000105514.7,RAB3D,19,Pancreatic secretion,,Neutrophil degranulation; RAB geranylgeranylation,7,High,1
Q96HR9,Receptor expression-enhancing protein 6 OS=Homo sapiens OX=9606 GN=REEP6 PE=1 SV=2,0,13.239,11,2,23,2,211,23.4,8.56,10769,,2,,regulation of biological process;response to stimulus,endoplasmic reticulum;membrane;nucleus,protein binding,Pf03134,92840,,REEP6,19,,,Olfactory Signaling Pathway; GPCR downstream signalling,4,High,1
Q14573,"Inositol 1,4,5-trisphosphate receptor type 3 OS=Homo sapiens OX=9606 GN=ITPR3 PE=1 SV=2",0,13.232,2,4,10,2,2671,303.9,6.48,4120,,4,,cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;membrane;nucleus,metal ion binding;protein binding;receptor activity;signal transducer activity;transporter activity,"Pf00520, Pf01027, Pf01365, Pf02815, Pf03772, Pf08454, Pf08709",3710,ENSG00000096433.10,ITPR3,6,Vascular smooth muscle contraction; Alzheimer's disease; Glucagon signaling pathway; Calcium signaling pathway; Insulin secretion; Inflammatory mediator regulation of TRP channels; cGMP-PKG signaling pathway; Aldosterone synthesis and secretion; Serotonergic synapse; Apoptosis; Phosphatidylinositol signaling system; Estrogen signaling pathway; Circadian entrainment; Gastric acid secretion; Thyroid hormone synthesis; Platelet activation; Renin secretion; Retrograde endocannabinoid signaling; Taste transduction; Cholinergic synapse; Glutamatergic synapse; Long-term depression; Gap junction; GnRH signaling pathway; NOD-like receptor signaling pathway; Proteoglycans in cancer; Long-term potentiation; Salivary secretion; Dopaminergic synapse; Pancreatic secretion; Oxytocin signaling pathway; Oocyte meiosis,Alzheimers Disease; Myometrial Relaxation and Contraction Pathways; MFAP5-mediated ovarian cancer cell motility and invasiveness; GPR40 PATHWAY; Calcium Regulation in the Cardiac Cell,Ion homeostasis; FCERI mediated Ca+2 mobilization; PLC beta mediated events; Ca2+ pathway; DAG and IP3 signaling; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Elevation of cytosolic Ca2+ levels; Effects of PIP2 hydrolysis; Gastrin-CREB signalling pathway via PKC and MAPK; VEGFR2 mediated cell proliferation; CLEC7A (Dectin-1) induces NFAT activation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of phospholipids in phagocytosis,79,High,1
Q8TB52,F-box only protein 30 OS=Homo sapiens OX=9606 GN=FBXO30 PE=1 SV=3,0,13.211,3,2,11,2,745,82.3,5.4,5472,,2,,metabolic process,cytosol,catalytic activity;metal ion binding;protein binding,"Pf00646, Pf02176, Pf12937",84085,ENSG00000118496.4,FBXO30,6,,,Antigen processing: Ubiquitination & Proteasome degradation; Neddylation,7,High,1
P10746,Uroporphyrinogen-III synthase OS=Homo sapiens OX=9606 GN=UROS PE=1 SV=1,0,13.178,10,2,15,2,265,28.6,5.48,6208,,2,,metabolic process;response to stimulus,cytosol;mitochondrion,catalytic activity,Pf02602,7390,ENSG00000188690.12,UROS,10,Porphyrin and chlorophyll metabolism; Metabolic pathways,Heme Biosynthesis,Heme biosynthesis,6,High,1
Q99933,BAG family molecular chaperone regulator 1 OS=Homo sapiens OX=9606 GN=BAG1 PE=1 SV=4,0,13.175,14,3,9,3,345,38.8,7.81,3800,,3,,cell death;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,enzyme regulator activity;nucleotide binding;protein binding;signal transducer activity,"Pf00240, Pf02179, Pf14560",573,,BAG1,9,Protein processing in endoplasmic reticulum,Androgen receptor signaling pathway,Regulation of HSF1-mediated heat shock response,6,High,1
Q9H7B2,Ribosome production factor 2 homolog OS=Homo sapiens OX=9606 GN=RPF2 PE=1 SV=2,0,13.157,16,4,20,4,306,35.6,9.99,8779,,4,,cell organization and biogenesis;metabolic process;regulation of biological process,nucleus,RNA binding,Pf04427,84154,ENSG00000197498.12,RPF2,6,,,,0,High,1
O00533,Neural cell adhesion molecule L1-like protein OS=Homo sapiens OX=9606 GN=CHL1 PE=1 SV=4,0,13.147,3,3,3,3,1208,135,5.76,1475,,3,,cell differentiation;cell organization and biogenesis;cellular component movement;development;regulation of biological process;response to stimulus,extracellular;membrane,protein binding,"Pf00041, Pf00047, Pf07679, Pf07686, Pf13882, Pf13895, Pf13927",10752,ENSG00000134121.9,CHL1,3,,,CHL1 interactions,4,High,1
Q5HYJ1,"Trans-2,3-enoyl-CoA reductase-like OS=Homo sapiens OX=9606 GN=TECRL PE=1 SV=1",0,13.143,4,1,36,1,363,42,9.57,,87.9,,1,metabolic process,cytoplasm;endoplasmic reticulum;membrane,catalytic activity,Pf02544,253017,ENSG00000205678.7,TECRL,4,,,Synthesis of very long-chain fatty acyl-CoAs,5,High,1
Q9NRA0,Sphingosine kinase 2 OS=Homo sapiens OX=9606 GN=SPHK2 PE=1 SV=2,0,13.083,7,3,11,3,654,69.2,6.95,3937,,3,,cell proliferation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;vacuole,catalytic activity;nucleotide binding;protein binding;receptor activity;signal transducer activity,Pf00781,56848,ENSG00000063176.15,SPHK2,19,Fc gamma R-mediated phagocytosis; Sphingolipid metabolism; Calcium signaling pathway; Sphingolipid signaling pathway; VEGF signaling pathway; Metabolic pathways; Tuberculosis,Sphingolipid Metabolism; Signal Transduction of S1P Receptor,Sphingolipid de novo biosynthesis,13,High,1
Q8WVI7,Protein phosphatase 1 regulatory subunit 1C OS=Homo sapiens OX=9606 GN=PPP1R1C PE=3 SV=1,0,13.079,33,2,12,2,109,12.3,6.8,1451,31.68,1,1,cell division;regulation of biological process;response to stimulus,cytoplasm,enzyme regulator activity,Pf05395,151242,ENSG00000150722.10,PPP1R1C,2,,,,0,High,1
Q6V1X1,Dipeptidyl peptidase 8 OS=Homo sapiens OX=9606 GN=DPP8 PE=1 SV=1,0,13.073,3,3,6,3,898,103.3,5.8,3307,,3,,metabolic process;response to stimulus,cytoplasm;cytosol,catalytic activity,"Pf00326, Pf00930, Pf02129, Pf02230, Pf12695, Pf12697",54878,ENSG00000074603.18,DPP8,15,,,,0,High,1
P25391,Laminin subunit alpha-1 OS=Homo sapiens OX=9606 GN=LAMA1 PE=1 SV=2,0,13.05,1,3,43,1,3075,336.9,6.35,21439,,3,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoskeleton;extracellular;membrane,catalytic activity;motor activity;protein binding;structural molecule activity,"Pf00052, Pf00053, Pf00054, Pf00055, Pf00754, Pf01576, Pf02210, Pf02463, Pf03302, Pf05483, Pf05701, Pf06008, Pf06009, Pf06160, Pf12785, Pf13166, Pf13385, Pf14992",284217,ENSG00000101680.14,LAMA1,18,PI3K-Akt signaling pathway; Toxoplasmosis; Small cell lung cancer; Amoebiasis; ECM-receptor interaction; Focal adhesion; Pathways in cancer,Alpha 6 Beta 4 signaling pathway; Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,ECM proteoglycans; L1CAM interactions; Laminin interactions; MET activates PTK2 signaling; Non-integrin membrane-ECM interactions,22,High,1
Q9BQP7,Mitochondrial genome maintenance exonuclease 1 OS=Homo sapiens OX=9606 GN=MGME1 PE=1 SV=1,0,13.037,10,3,7,3,344,39.4,7.68,2761,,3,,cell organization and biogenesis;metabolic process;response to stimulus,mitochondrion,catalytic activity;DNA binding,,92667,ENSG00000125871.13,C20orf72; MGME1,20,,,,0,High,1
Q8TDY2,RB1-inducible coiled-coil protein 1 OS=Homo sapiens OX=9606 GN=RB1CC1 PE=1 SV=3,0,13.033,2,3,7,3,1594,183,5.41,4249,,3,,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,protein binding;structural molecule activity,"Pf03938, Pf04111, Pf05667, Pf10377, Pf12128",9821,ENSG00000023287.12,RB1CC1,8,Longevity regulating pathway,PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Senescence and Autophagy in Cancer,Macroautophagy,5,High,1
Q13905,Rap guanine nucleotide exchange factor 1 OS=Homo sapiens OX=9606 GN=RAPGEF1 PE=1 SV=3,0,13.025,4,3,7,3,1077,120.5,5.92,2301,,3,,regulation of biological process;response to stimulus,cytoplasm;cytosol;endosome;membrane,protein binding,"Pf00617, Pf00618",2889,ENSG00000107263.18,RAPGEF1,9,Rap1 signaling pathway; Focal adhesion; Insulin signaling pathway; Renal cell carcinoma; Neurotrophin signaling pathway,Integrin-mediated Cell Adhesion; B Cell Receptor Signaling Pathway; IL-3 Signaling Pathway; Focal Adhesion; Signaling of Hepatocyte Growth Factor Receptor; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; Insulin Signaling; Interferon type I signaling pathways,Frs2-mediated activation; Regulation of signaling by CBL; MET activates RAP1 and RAC1; Downstream signal transduction,31,High,1
P08637,Low affinity immunoglobulin gamma Fc region receptor III-A OS=Homo sapiens OX=9606 GN=FCGR3A PE=1 SV=2,0,13.025,9,2,8,2,254,29.1,8.07,2624,,2,,regulation of biological process;response to stimulus,extracellular;membrane,protein binding,"Pf07679, Pf13895, Pf13927",2214,ENSG00000203747.10,FCGR3A,1,Phagosome; Osteoclast differentiation; Fc gamma R-mediated phagocytosis; Natural killer cell mediated cytotoxicity; Systemic lupus erythematosus; Tuberculosis; Leishmaniasis; Staphylococcus aureus infection,,FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Role of phospholipids in phagocytosis,16,High,1
Q9Y6W3,Calpain-7 OS=Homo sapiens OX=9606 GN=CAPN7 PE=1 SV=1,0,13.02,8,4,7,4,813,92.6,7.65,2334,,4,,metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,"Pf00648, Pf01067, Pf04212",23473,ENSG00000131375.9,CAPN7,3,,Integrin-mediated Cell Adhesion,Degradation of the extracellular matrix,3,High,1
Q9BVM2,Protein DPCD OS=Homo sapiens OX=9606 GN=DPCD PE=1 SV=2,0,13.009,13,3,21,3,203,23.2,9.03,10346,,3,,cellular component movement,nucleus,protein binding,Pf14913,25911,ENSG00000166171.12,DPCD,10,,,,0,High,1
Q9BVP2,Guanine nucleotide-binding protein-like 3 OS=Homo sapiens OX=9606 GN=GNL3 PE=1 SV=2,0,13.001,10,4,6,4,549,62,9.16,1918,,4,,cell division;cell proliferation;regulation of biological process,membrane;nucleus,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf01926, Pf02421, Pf08701",26354,ENSG00000163938.16,GNL3,3,Ribosome biogenesis in eukaryotes,,Major pathway of rRNA processing in the nucleolus and cytosol,5,High,1
Q9NNW5,WD repeat-containing protein 6 OS=Homo sapiens OX=9606 GN=WDR6 PE=1 SV=1,0,12.998,6,3,6,3,1121,121.6,6.87,1861,,3,,regulation of biological process,cytoplasm;cytosol;membrane,protein binding;RNA binding,Pf00400,11180,ENSG00000178252.17,WDR6,3,,,,0,High,1
Q8N0Z6,Tetratricopeptide repeat protein 5 OS=Homo sapiens OX=9606 GN=TTC5 PE=1 SV=2,0,12.995,7,3,9,3,440,48.9,6.48,3986,,3,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,DNA binding;protein binding,"Pf13414, Pf13424, Pf13432",91875,ENSG00000136319.11,TTC5,14,,,Regulation of TP53 Activity through Methylation,6,High,1
Q5VYX0,Renalase OS=Homo sapiens OX=9606 GN=RNLS PE=1 SV=1,0,12.993,13,3,6,3,342,37.8,6.52,2117,3.34,2,1,metabolic process;regulation of biological process;response to stimulus,extracellular,catalytic activity;nucleotide binding,"Pf01593, Pf13450",55328,ENSG00000184719.11,RNLS,10,,,Nicotinamide salvaging,5,High,1
O43739,Cytohesin-3 OS=Homo sapiens OX=9606 GN=CYTH3 PE=1 SV=2,0,12.97,11,4,15,2,400,46.3,5.47,5769,,4,,regulation of biological process;transport,cytoplasm;cytosol;membrane,protein binding,"Pf00169, Pf01369, Pf15413",9265,ENSG00000008256.15,CYTH3,7,Phospholipase D signaling pathway; Endocytosis,Insulin Signaling,Intra-Golgi traffic,7,High,1
Q712K3,Ubiquitin-conjugating enzyme E2 R2 OS=Homo sapiens OX=9606 GN=UBE2R2 PE=1 SV=1,0,12.962,11,3,21,2,238,27.1,4.42,8923,,3,,metabolic process,cytoplasm;cytosol,catalytic activity;nucleotide binding;protein binding,"Pf00179, Pf14461",54926,ENSG00000107341.4,UBE2R2,9,Herpes simplex infection; Ubiquitin mediated proteolysis,,Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation,10,High,1
Q8IWX8,Calcium homeostasis endoplasmic reticulum protein OS=Homo sapiens OX=9606 GN=CHERP PE=1 SV=3,0,12.961,10,6,11,6,916,103.6,9.04,3196,,6,,cellular homeostasis;metabolic process;regulation of biological process;transport,cytoplasm;endoplasmic reticulum;membrane,protein binding;RNA binding,"Pf01585, Pf01805, Pf04818",10523,ENSG00000085872.14,CHERP,19,Spliceosome,,mRNA Splicing - Major Pathway,5,High,1
Q9Y6I8,Peroxisomal membrane protein 4 OS=Homo sapiens OX=9606 GN=PXMP4 PE=1 SV=3,0,12.952,11,3,15,3,212,24.2,10.07,6524,,3,,,membrane,protein binding,Pf02466,11264,ENSG00000101417.11,PXMP4,20,Peroxisome,,,1,High,1
Q9Y2U8,Inner nuclear membrane protein Man1 OS=Homo sapiens OX=9606 GN=LEMD3 PE=1 SV=2,0,12.949,7,4,7,4,911,99.9,7.55,2171,,4,,cell organization and biogenesis;regulation of biological process,membrane;nucleus,DNA binding;protein binding,"Pf03020, Pf09402",23592,ENSG00000174106.2,LEMD3,12,,,Depolymerisation of the Nuclear Lamina; Initiation of Nuclear Envelope Reformation; Clearance of Nuclear Envelope Membranes from Chromatin,11,High,1
Q9UGM5,Fetuin-B OS=Homo sapiens OX=9606 GN=FETUB PE=1 SV=2,0,12.941,9,3,14,3,382,42,6.83,6592,,3,,regulation of biological process,extracellular,enzyme regulator activity,Pf00031,26998,ENSG00000090512.11,FETUB,3,,,,0,High,1
P98170,E3 ubiquitin-protein ligase XIAP OS=Homo sapiens OX=9606 GN=XIAP PE=1 SV=2,0,12.941,11,4,7,4,497,56.6,6.65,2526,,4,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;enzyme regulator activity;metal ion binding;protein binding,"Pf00653, Pf13920, Pf13923",331,ENSG00000101966.12,XIAP,X,HTLV-I infection; NOD-like receptor signaling pathway; Apoptosis; Apoptosis - multiple species; Platinum drug resistance; Ubiquitin mediated proteolysis; Focal adhesion; Toxoplasmosis; NF-kappa B signaling pathway; Pathways in cancer; Small cell lung cancer,Nucleotide-binding Oligomerization Domain (NOD) pathway; Apoptosis Modulation and Signaling; Apoptosis; Focal Adhesion; Copper homeostasis,Regulation of PTEN stability and activity; Deactivation of the beta-catenin transactivating complex; Regulation of necroptotic cell death; SMAC-mediated dissociation of IAP:caspase complexes ; SMAC binds to IAPs ; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; Regulation of PTEN localization,39,High,1
Q9Y2I7,1-phosphatidylinositol 3-phosphate 5-kinase OS=Homo sapiens OX=9606 GN=PIKFYVE PE=1 SV=3,0,12.935,2,4,7,4,2098,237,6.7,2268,,4,,metabolic process;regulation of biological process;response to stimulus;transport,cytosol;endosome;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00118, Pf00610, Pf01363, Pf01504",200576,ENSG00000115020.16,PIKFYVE,2,Phosphatidylinositol signaling system; Phagosome; Regulation of actin cytoskeleton; Inositol phosphate metabolism,,Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane,11,High,1
O15270,Serine palmitoyltransferase 2 OS=Homo sapiens OX=9606 GN=SPTLC2 PE=1 SV=1,0,12.929,10,4,9,4,562,62.9,7.78,3214,,4,,metabolic process,endoplasmic reticulum;membrane;mitochondrion,catalytic activity,"Pf00155, Pf01212",9517,ENSG00000100596.6,SPTLC2,14,Sphingolipid signaling pathway; Sphingolipid metabolism; Metabolic pathways,Sphingolipid Metabolism,Sphingolipid de novo biosynthesis,8,High,1
Q8WXH4,Ankyrin repeat and SOCS box protein 11 OS=Homo sapiens OX=9606 GN=ASB11 PE=1 SV=1,0,12.909,18,3,4,3,323,35.3,8.07,,13.18,,3,metabolic process;regulation of biological process;response to stimulus,cytosol,protein binding,"Pf00023, Pf07525, Pf12796, Pf13637, Pf13857",140456,ENSG00000165192.13,ASB11,X,,,Antigen processing: Ubiquitination & Proteasome degradation; Neddylation,7,High,1
Q9P013,Spliceosome-associated protein CWC15 homolog OS=Homo sapiens OX=9606 GN=CWC15 PE=1 SV=2,0,12.896,18,3,6,3,229,26.6,5.71,2521,,3,,metabolic process,mitochondrion;nucleus;spliceosomal complex,protein binding;RNA binding,Pf04889,51503,ENSG00000150316.11,CWC15,11,Spliceosome,,mRNA Splicing - Major Pathway,5,High,1
Q8WWH5,Probable tRNA pseudouridine synthase 1 OS=Homo sapiens OX=9606 GN=TRUB1 PE=1 SV=1,0,12.892,13,4,11,4,349,37.2,8.25,3478,,4,,metabolic process,mitochondrion,catalytic activity;RNA binding,Pf01509,142940,ENSG00000165832.5,TRUB1,10,,,,0,High,1
Q9NVZ3,Adaptin ear-binding coat-associated protein 2 OS=Homo sapiens OX=9606 GN=NECAP2 PE=1 SV=1,0,12.891,20,3,15,3,263,28.3,8.38,5380,,3,,transport,membrane,,Pf07933,55707,ENSG00000157191.19,NECAP2,1,,,Cargo recognition for clathrin-mediated endocytosis,4,High,1
P50750,Cyclin-dependent kinase 9 OS=Homo sapiens OX=9606 GN=CDK9 PE=1 SV=3,0,12.888,13,4,11,4,372,42.8,8.79,3218,,4,,cell proliferation;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;membrane;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding,"Pf00069, Pf07714",1025,ENSG00000136807.13,CDK9,9,Transcriptional misregulation in cancer,MicroRNAs in cardiomyocyte hypertrophy; IL-9 Signaling Pathway; Cardiac Hypertrophic Response; Initiation of transcription and translation elongation at the HIV-1 LTR,RNA polymerase II transcribes snRNA genes; Interactions of Tat with host cellular proteins; Tat-mediated HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; Formation of HIV-1 elongation complex containing HIV-1 Tat; HIV elongation arrest and recovery; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; TP53 Regulates Transcription of DNA Repair Genes; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; Formation of HIV elongation complex in the absence of HIV Tat; Pausing and recovery of Tat-mediated HIV elongation,35,High,1
Q9NXD2,Myotubularin-related protein 10 OS=Homo sapiens OX=9606 GN=MTMR10 PE=1 SV=3,0,12.864,4,2,8,2,777,88.2,8.53,3865,,2,,,cytosol,,"Pf06602, Pf12578",54893,ENSG00000277086.3; ENSG00000166912.16,MTMR10,15; CHR_HSCHR15_4_CTG8,,,Synthesis of PIPs at the early endosome membrane,5,High,1
Q86VR2,Reticulophagy regulator 3 OS=Homo sapiens OX=9606 GN=RETREG3 PE=1 SV=1,0,12.862,8,3,137,2,466,51.4,4.97,58470,,3,,regulation of biological process,membrane,protein binding,Pf02453,162427,ENSG00000141699.10,FAM134C; RETREG3,17,,,,0,High,1
Q9BZ67,FERM domain-containing protein 8 OS=Homo sapiens OX=9606 GN=FRMD8 PE=1 SV=1,0,12.85,11,3,11,3,464,51.2,6.23,3659,,3,,,cytoskeleton,protein binding,Pf00373,83786,ENSG00000126391.13,FRMD8,11,,,,0,High,1
Q9NRP4,"Succinate dehydrogenase assembly factor 3, mitochondrial OS=Homo sapiens OX=9606 GN=SDHAF3 PE=1 SV=1",0,12.844,28,2,15,2,125,14.6,9.07,7382,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,mitochondrion;organelle lumen,,"Pf05347, Pf13233",57001,ENSG00000196636.7,ACN9; SDHAF3,7,,,,0,High,1
P62891,60S ribosomal protein L39 OS=Homo sapiens OX=9606 GN=RPL39 PE=1 SV=2,0,12.818,20,1,91,1,51,6.4,12.56,47593,,1,,cell organization and biogenesis;defense response;metabolic process;response to stimulus;transport,cytosol;ribosome,RNA binding;structural molecule activity,Pf00832,6170; 285785,ENSG00000198918.7,RPL39; RPL39P3,X; 6,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
O75604,Ubiquitin carboxyl-terminal hydrolase 2 OS=Homo sapiens OX=9606 GN=USP2 PE=1 SV=2,0,12.818,9,4,12,4,605,68,8.97,2691,4.85,2,2,metabolic process;regulation of biological process;response to stimulus,cytoplasm;membrane;nucleus,catalytic activity;metal ion binding;protein binding,"Pf00443, Pf13423",9099,ENSG00000036672.15,USP2,11,,,Ub-specific processing proteases; TNFR1-induced proapoptotic signaling; Regulation of TP53 Degradation; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway,17,High,1
Q14999,Cullin-7 OS=Homo sapiens OX=9606 GN=CUL7 PE=1 SV=2,0,12.813,3,3,7,3,1698,191,5.87,2101,,3,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytoskeleton;cytosol;Golgi,protein binding,"Pf00888, Pf03256, Pf11515",9820,ENSG00000044090.8,CUL7,6,Ubiquitin mediated proteolysis,,XBP1(S) activates chaperone genes; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation,11,High,1
Q9BQE4,Selenoprotein S OS=Homo sapiens OX=9606 GN=SELENOS PE=1 SV=3,0,12.767,12,2,10,2,189,21.2,9.7,4938,,2,,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;membrane,antioxidant activity;catalytic activity;protein binding;receptor activity,Pf06936,55829,ENSG00000131871.14,VIMP; SELENOS,15,Protein processing in endoplasmic reticulum,Selenium Micronutrient Network; Selenium Metabolism and Selenoproteins,E3 ubiquitin ligases ubiquitinate target proteins,7,High,1
P53602,Diphosphomevalonate decarboxylase OS=Homo sapiens OX=9606 GN=MVD PE=1 SV=1,0,12.758,17,4,7,4,400,43.4,7.23,2237,,4,,metabolic process;regulation of biological process,cytosol,catalytic activity;nucleotide binding;protein binding,,4597,ENSG00000167508.11,MVD,16,Metabolic pathways; Terpenoid backbone biosynthesis,Cholesterol Biosynthesis; Sterol Regulatory Element-Binding Proteins (SREBP) signalling,Synthesis of Dolichyl-phosphate; Cholesterol biosynthesis; Activation of gene expression by SREBF (SREBP),16,High,1
Q8NI36,WD repeat-containing protein 36 OS=Homo sapiens OX=9606 GN=WDR36 PE=1 SV=1,0,12.737,4,3,9,3,951,105.3,7.53,3037,,3,,metabolic process;regulation of biological process;response to stimulus,nucleus,protein binding;RNA binding,"Pf00400, Pf04192",134430,ENSG00000134987.11,WDR36,5,Ribosome biogenesis in eukaryotes,,Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol,6,High,1
Q9Y3T6,R3H and coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=R3HCC1 PE=1 SV=3,0,12.734,8,3,14,3,440,49.1,5.63,6304,,3,,,,,Pf01424,203069,,R3HCC1,8,,,,0,High,1
Q7L4S7,Protein ARMCX6 OS=Homo sapiens OX=9606 GN=ARMCX6 PE=2 SV=1,0,12.724,9,1,3,1,300,33,4.78,2466,,1,,,membrane;mitochondrion,,Pf04826,54470,ENSG00000198960.10,ARMCX6,X,,,,0,High,1
P04626,Receptor tyrosine-protein kinase erbB-2 OS=Homo sapiens OX=9606 GN=ERBB2 PE=1 SV=1,0,12.71,2,4,23,3,1255,137.8,5.91,8830,,4,,cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding;receptor activity;signal transducer activity,"Pf00069, Pf00757, Pf01030, Pf07714, Pf14843",2064,ENSG00000141736.13,ERBB2,17,Endometrial cancer; Calcium signaling pathway; Pancreatic cancer; Adherens junction; EGFR tyrosine kinase inhibitor resistance; ErbB signaling pathway; Platinum drug resistance; Non-small cell lung cancer; Bladder cancer; Central carbon metabolism in cancer; Focal adhesion; Pathways in cancer; Endocrine resistance; Proteoglycans in cancer; Prostate cancer; Breast cancer; MicroRNAs in cancer; HIF-1 signaling pathway,Leptin signaling pathway; Prolactin Signaling Pathway; Signaling Pathways in Glioblastoma; Bladder Cancer; Extracellular vesicle-mediated signaling in recipient cells; Focal Adhesion; Rac1/Pak1/p38/MMP-2 pathway; Pathways Affected in Adenoid Cystic Carcinoma; Association Between Physico-Chemical Features and Toxicity Associated Pathways; EGF/EGFR Signaling Pathway; ErbB Signaling Pathway; DNA Damage Response (only ATM dependent),"TFAP2 (AP-2) family regulates transcription of growth factors and their receptors; SHC1 events in ERBB2 signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GRB7 events in ERBB2 signaling; Downregulation of ERBB2:ERBB3 signaling; ERBB2 Regulates Cell Motility; PLCG1 events in ERBB2 signaling; ERBB2 Activates PTK6 Signaling; Sema4D induced cell migration and growth-cone collapse; GRB2 events in ERBB2 signaling; PI3K events in ERBB2 signaling; Constitutive Signaling by Aberrant PI3K in Cancer; RAF/MAP kinase cascade; Interleukin-20 family signaling",69,High,1
Q9P0S3,ORM1-like protein 1 OS=Homo sapiens OX=9606 GN=ORMDL1 PE=1 SV=1,0,12.662,17,2,4,1,153,17.4,9.64,1969,,2,,cellular homeostasis;metabolic process;regulation of biological process,endoplasmic reticulum;membrane,,Pf04061,94101,ENSG00000128699.13,ORMDL1,2,,,Sphingolipid de novo biosynthesis,4,High,1
O43150,"Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ASAP2 PE=1 SV=3",0,12.655,4,3,17,3,1006,111.6,6.68,5353,,3,,regulation of biological process,cytoplasm;Golgi;membrane,enzyme regulator activity;metal ion binding;protein binding,"Pf00018, Pf00023, Pf00169, Pf01412, Pf07653, Pf12796, Pf13637, Pf13857, Pf14604",8853,ENSG00000151693.9,ASAP2,2,Endocytosis; Fc gamma R-mediated phagocytosis,,,2,High,1
P40222,Alpha-taxilin OS=Homo sapiens OX=9606 GN=TXLNA PE=1 SV=3,0,12.625,7,4,11,4,546,61.9,6.52,4765,,4,,cell proliferation;regulation of biological process;transport,cytoplasm;cytosol;extracellular;membrane,protein binding,Pf09728,200081,ENSG00000084652.15,TXLNA,1,,,Other interleukin signaling,4,High,1
Q13322,Growth factor receptor-bound protein 10 OS=Homo sapiens OX=9606 GN=GRB10 PE=1 SV=2,0,12.625,5,2,3,2,594,67.2,7.87,1348,,2,,cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,protein binding,"Pf00017, Pf00169, Pf00788, Pf08947",2887,ENSG00000106070.17,GRB10,7,mTOR signaling pathway,Kit receptor signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; VEGFA-VEGFR2 Signaling Pathway; EGF/EGFR Signaling Pathway; Insulin Signaling,RET signaling; Signaling by SCF-KIT; Signal attenuation; IRS activation,16,High,1
Q9BYZ2,L-lactate dehydrogenase A-like 6B OS=Homo sapiens OX=9606 GN=LDHAL6B PE=1 SV=3,0,12.624,6,2,189,1,381,41.9,8.65,104463,,2,,metabolic process,cytoplasm;nucleus;organelle lumen,catalytic activity;protein binding,"Pf00056, Pf02866",92483,ENSG00000171989.5,LDHAL6B,15,Pyruvate metabolism; Cysteine and methionine metabolism; Glucagon signaling pathway; Metabolic pathways; Glycolysis / Gluconeogenesis; Propanoate metabolism,Glycolysis and Gluconeogenesis,Pyruvate metabolism,11,High,1
P47712,Cytosolic phospholipase A2 OS=Homo sapiens OX=9606 GN=PLA2G4A PE=1 SV=2,0,12.623,5,3,5,3,749,85.2,5.38,1749,,3,,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;Golgi;membrane,catalytic activity;metal ion binding;protein binding,"Pf00168, Pf01735",5321,ENSG00000116711.9,PLA2G4A,1,Platelet activation; Long-term depression; Glutamatergic synapse; alpha-Linolenic acid metabolism; Oxytocin signaling pathway; Glycerophospholipid metabolism; Ovarian steroidogenesis; Fc gamma R-mediated phagocytosis; Arachidonic acid metabolism; Serotonergic synapse; Fc epsilon RI signaling pathway; Phospholipase D signaling pathway; GnRH signaling pathway; Linoleic acid metabolism; Ether lipid metabolism; Inflammatory mediator regulation of TRP channels; VEGF signaling pathway; Metabolic pathways; Choline metabolism in cancer; Vascular smooth muscle contraction; Ras signaling pathway; MAPK signaling pathway,AGE/RAGE pathway; Nanoparticle triggered regulated necrosis; PDGF Pathway; VEGFA-VEGFR2 Signaling Pathway; p38 MAPK Signaling Pathway; Prostaglandin Synthesis and Regulation,COPI-independent Golgi-to-ER retrograde traffic; Acyl chain remodelling of PI; Acyl chain remodelling of PG; Hydrolysis of LPC; Arachidonic acid metabolism; ADP signalling through P2Y purinoceptor 1; phospho-PLA2 pathway; Acyl chain remodeling of CL; Acyl chain remodelling of PS; Acyl chain remodelling of PE; Platelet sensitization by LDL; Signaling by GPCR; Synthesis of PA; Acyl chain remodelling of PC,60,High,1
O14981,TATA-binding protein-associated factor 172 OS=Homo sapiens OX=9606 GN=BTAF1 PE=1 SV=2,0,12.589,2,3,8,3,1849,206.8,6.52,3308,0,3,1,regulation of biological process,nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding,"Pf00176, Pf00271, Pf12054",9044,ENSG00000095564.13,BTAF1,10,,,,0,High,1
Q86VU5,Catechol O-methyltransferase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=COMTD1 PE=1 SV=1,0,12.579,16,3,34,3,262,28.8,8.38,15952,,3,,metabolic process,membrane;mitochondrion,catalytic activity;protein binding,"Pf01596, Pf12847, Pf13578, Pf13659",118881,ENSG00000165644.10,COMTD1,10,,,,0,High,1
P06280,Alpha-galactosidase A OS=Homo sapiens OX=9606 GN=GLA PE=1 SV=1,0,12.577,5,2,7,2,429,48.7,5.6,3685,,2,,metabolic process;regulation of biological process;transport,cytoplasm;extracellular;Golgi;organelle lumen;vacuole,catalytic activity;protein binding,Pf02065,2717,ENSG00000102393.9,GLA,X,Lysosome; Glycerolipid metabolism; Sphingolipid metabolism; Glycosphingolipid biosynthesis - globo and isoglobo series; Galactose metabolism,,Glycosphingolipid metabolism; Neutrophil degranulation,12,High,1
Q8IZ73,RNA pseudouridylate synthase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=RPUSD2 PE=1 SV=2,0,12.546,7,2,3,2,545,61.3,7.17,1706,,2,,metabolic process,,catalytic activity;RNA binding,Pf00849,27079,ENSG00000166133.17,RPUSD2,15,,,,0,High,1
Q96AY3,Peptidyl-prolyl cis-trans isomerase FKBP10 OS=Homo sapiens OX=9606 GN=FKBP10 PE=1 SV=1,0,12.535,12,4,12,4,582,64.2,5.62,4238,,4,,cell organization and biogenesis;metabolic process,cytoplasm;endoplasmic reticulum;organelle lumen,catalytic activity;metal ion binding,Pf00254,60681,ENSG00000141756.18,FKBP10,17,,,,0,High,1
Q9H8T0,AKT-interacting protein OS=Homo sapiens OX=9606 GN=AKTIP PE=1 SV=1,0,12.535,15,2,6,2,292,33.1,9.31,2611,,2,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;membrane,catalytic activity;protein binding,Pf00179,64400,ENSG00000166971.16,AKTIP,16,,,,0,High,1
Q9HCU0,Endosialin OS=Homo sapiens OX=9606 GN=CD248 PE=1 SV=1,0,12.53,5,4,9,4,757,80.8,5.35,3133,,4,,cellular component movement;regulation of biological process,cytoplasm;membrane,metal ion binding,"Pf00059, Pf03154, Pf07645, Pf09770, Pf12662, Pf14670",57124,ENSG00000174807.3,CD248,11,,,,0,High,1
Q99759,Mitogen-activated protein kinase kinase kinase 3 OS=Homo sapiens OX=9606 GN=MAP3K3 PE=1 SV=2,0,12.523,8,4,13,4,626,70.9,8.84,4837,,4,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf00564, Pf07714, Pf14531",4215,ENSG00000198909.7,MAP3K3,17,MAPK signaling pathway; HTLV-I infection; Neurotrophin signaling pathway; GnRH signaling pathway,IL-1 signaling pathway; TNF alpha Signaling Pathway; EBV LMP1 signaling; Angiopoietin Like Protein 8 Regulatory Pathway; MAPK Cascade; EGF/EGFR Signaling Pathway; Insulin Signaling,Interleukin-1 family signaling,15,High,1
Q5SVS4,Kidney mitochondrial carrier protein 1 OS=Homo sapiens OX=9606 GN=SLC25A30 PE=1 SV=1,0,12.513,16,3,8,3,291,32.5,9.44,2270,3,2,1,transport,membrane;mitochondrion,protein binding;transporter activity,Pf00153,253512,ENSG00000174032.16,SLC25A30,13,,,,0,High,1
O14986,Phosphatidylinositol 4-phosphate 5-kinase type-1 beta OS=Homo sapiens OX=9606 GN=PIP5K1B PE=1 SV=2,0,12.508,5,2,7,1,540,61,6.86,3371,,2,,metabolic process;regulation of biological process,cytosol;membrane,catalytic activity;nucleotide binding;protein binding,Pf01504,8395,ENSG00000107242.17,PIP5K1B,9,Metabolic pathways; Inositol phosphate metabolism; Regulation of actin cytoskeleton; Phospholipase D signaling pathway; Fc gamma R-mediated phagocytosis; Choline metabolism in cancer; Phosphatidylinositol signaling system; Endocytosis,B Cell Receptor Signaling Pathway; Wnt Signaling Pathway Netpath; Regulation of Actin Cytoskeleton,"WNT mediated activation of DVL; Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling",24,High,1
Q86UA1,Pre-mRNA-processing factor 39 OS=Homo sapiens OX=9606 GN=PRPF39 PE=1 SV=3,0,12.503,6,3,3,3,669,78.4,5.4,1390,,3,,cell organization and biogenesis;metabolic process,nucleus;spliceosomal complex,protein binding;RNA binding,,55015,ENSG00000185246.17,PRPF39,14,,,,0,High,1
Q6ZMG9,Ceramide synthase 6 OS=Homo sapiens OX=9606 GN=CERS6 PE=1 SV=1,0,12.478,5,3,53,3,384,44.9,7.65,18632,,3,,metabolic process,endoplasmic reticulum;membrane;nucleus,catalytic activity;DNA binding,"Pf00046, Pf03798",253782,ENSG00000172292.14,CERS6,2,Sphingolipid signaling pathway; Metabolic pathways; Sphingolipid metabolism,Sphingolipid Metabolism,Sphingolipid de novo biosynthesis,8,High,1
P20585,DNA mismatch repair protein Msh3 OS=Homo sapiens OX=9606 GN=MSH3 PE=1 SV=4,0,12.474,4,3,5,3,1137,127.3,8.02,2344,,3,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,membrane,catalytic activity;DNA binding;nucleotide binding;protein binding,"Pf00488, Pf01624, Pf05188, Pf05190, Pf05192",4437,ENSG00000113318.9,MSH3,5,Colorectal cancer; Mismatch repair; Platinum drug resistance; Pathways in cancer,,Defective Mismatch Repair Associated With MSH3; Defective Mismatch Repair Associated With MSH2; Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta),11,High,1
P0DP06,Immunoglobulin heavy variable 4-30-4 OS=Homo sapiens OX=9606 GN=IGHV4-30-4 PE=3 SV=1,0,12.469,20,3,18,1,118,13.1,9.26,5883,,3,,response to stimulus,extracellular;membrane,,Pf07686,28397,,IGHV4-30-4,14,,,,0,High,1
Q9Y5B6,PAX3- and PAX7-binding protein 1 OS=Homo sapiens OX=9606 GN=PAXBP1 PE=1 SV=2,0,12.469,6,3,5,3,917,104.7,5.68,2303,,3,,metabolic process;regulation of biological process,cytosol;nucleus,DNA binding;protein binding,Pf07842,94104,ENSG00000159086.14,GCFC1; PAXBP1,21,,,,0,High,1
P10620,Microsomal glutathione S-transferase 1 OS=Homo sapiens OX=9606 GN=MGST1 PE=1 SV=1,0,12.463,18,2,10,2,155,17.6,9.39,4633,,2,,cell differentiation;cell organization and biogenesis;metabolic process;response to stimulus;transport,endoplasmic reticulum;membrane;mitochondrion;nucleus,antioxidant activity;catalytic activity;protein binding,Pf01124,4257,ENSG00000008394.12,MGST1,12,Chemical carcinogenesis; Glutathione metabolism; Drug metabolism - cytochrome P450; Platinum drug resistance; Metabolism of xenobiotics by cytochrome P450,Aryl Hydrocarbon Receptor Pathway; Oxidative Stress; Metapathway biotransformation,Glutathione conjugation; Neutrophil degranulation; Aflatoxin activation and detoxification,16,High,1
Q9UQB3,Catenin delta-2 OS=Homo sapiens OX=9606 GN=CTNND2 PE=1 SV=3,0,12.453,2,2,16,1,1225,132.6,7.74,8705,,2,,cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,protein binding,Pf00514,1501,ENSG00000169862.18,CTNND2,5,,Ectoderm Differentiation,,1,High,1
Q9UL33,Trafficking protein particle complex subunit 2-like protein OS=Homo sapiens OX=9606 GN=TRAPPC2L PE=1 SV=1,0,12.446,26,3,12,3,140,16.1,6.77,4998,,3,,cell organization and biogenesis;transport,cytoplasm;cytosol;endoplasmic reticulum;Golgi;membrane,protein binding,"Pf04099, Pf04628",51693,ENSG00000167515.10,TRAPPC2L,16,,,RAB GEFs exchange GTP for GDP on RABs; COPII (Coat Protein 2) Mediated Vesicle Transport,10,High,1
Q5VSL9,Striatin-interacting protein 1 OS=Homo sapiens OX=9606 GN=STRIP1 PE=1 SV=1,0,12.44,3,3,23,1,837,95.5,6.29,9671,,3,,cell organization and biogenesis;regulation of biological process,cytoplasm;cytosol;nucleus,protein binding,"Pf07923, Pf11882",85369,ENSG00000143093.14,STRIP1,1,,,,0,High,1
O00244,Copper transport protein ATOX1 OS=Homo sapiens OX=9606 GN=ATOX1 PE=1 SV=1,0,12.437,13,2,27,2,68,7.4,7.24,14933,,2,,cellular homeostasis;response to stimulus;transport,cytosol,metal ion binding;protein binding;transporter activity,Pf00403,475,ENSG00000177556.11,ATOX1,5,Mineral absorption,Copper homeostasis,Ion influx/efflux at host-pathogen interface; Detoxification of Reactive Oxygen Species,9,High,1
Q15334,Lethal(2) giant larvae protein homolog 1 OS=Homo sapiens OX=9606 GN=LLGL1 PE=1 SV=3,0,12.433,4,3,4,3,1064,115.3,6.29,1638,,3,,cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytoskeleton;endosome;Golgi;membrane,enzyme regulator activity;protein binding;structural molecule activity,Pf08366,3996,ENSG00000131899.10; ENSG00000284137.1,LLGL1,17; CHR_HSCHR17_3_CTG1,Hippo signaling pathway; Tight junction,,,2,High,1
Q9NPE3,H/ACA ribonucleoprotein complex subunit 3 OS=Homo sapiens OX=9606 GN=NOP10 PE=1 SV=1,0,12.429,33,2,8,2,64,7.7,9.99,4220,,2,,cell organization and biogenesis;metabolic process,nucleus,protein binding;RNA binding,Pf04135,55505,ENSG00000182117.5,NOP10,15,Ribosome biogenesis in eukaryotes,,rRNA modification in the nucleus and cytosol,5,High,1
Q86YT6,E3 ubiquitin-protein ligase MIB1 OS=Homo sapiens OX=9606 GN=MIB1 PE=1 SV=1,0,12.426,4,3,9,3,1006,110.1,6.92,3762,,3,,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane,catalytic activity;metal ion binding;protein binding,"Pf00023, Pf00569, Pf06701, Pf12796, Pf13606, Pf13637, Pf13857, Pf13920, Pf13923, Pf14634",57534,ENSG00000101752.11,MIB1,18,,,Activated NOTCH1 Transmits Signal to the Nucleus; NOTCH2 Activation and Transmission of Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants,15,High,1
Q9GZQ8,Microtubule-associated proteins 1A/1B light chain 3B OS=Homo sapiens OX=9606 GN=MAP1LC3B PE=1 SV=3,0,12.419,11,1,21,1,125,14.7,8.94,9797,,1,,cell communication;cell organization and biogenesis;metabolic process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;vacuole,protein binding,"Pf02991, Pf04110",81631,ENSG00000140941.12,MAP1LC3B,16,,Senescence and Autophagy in Cancer,TBC/RABGAPs; Macroautophagy; Receptor Mediated Mitophagy; Pink/Parkin Mediated Mitophagy,10,High,1
P10176,"Cytochrome c oxidase subunit 8A, mitochondrial OS=Homo sapiens OX=9606 GN=COX8A PE=1 SV=2",0,12.413,26,2,68,2,69,7.6,10.24,28874,,2,,metabolic process;transport,membrane;mitochondrion,catalytic activity;protein binding;transporter activity,Pf02285,1351,ENSG00000176340.3,COX8A,11,Cardiac muscle contraction; Oxidative phosphorylation; Huntington's disease; Metabolic pathways; Alzheimer's disease; Non-alcoholic fatty liver disease (NAFLD); Parkinson's disease,Electron Transport Chain; Arachidonate Epoxygenase / Epoxide Hydrolase,TP53 Regulates Metabolic Genes; Respiratory electron transport,18,High,1
Q5H9U9,Probable ATP-dependent RNA helicase DDX60-like OS=Homo sapiens OX=9606 GN=DDX60L PE=2 SV=2,0,12.403,1,3,10,1,1706,197.5,8.29,4751,,3,,,,catalytic activity;DNA binding;nucleotide binding;RNA binding,"Pf00270, Pf00271, Pf04851",91351,,DDX60L,4,,,,0,High,1
Q9BSU1,UPF0183 protein C16orf70 OS=Homo sapiens OX=9606 GN=C16orf70 PE=1 SV=1,0,12.384,12,3,6,3,422,47.5,7.72,2437,,3,,,,protein binding,Pf03676,80262,ENSG00000125149.11,C16orf70,16,,,,0,High,1
Q9H7M9,V-type immunoglobulin domain-containing suppressor of T-cell activation OS=Homo sapiens OX=9606 GN=VSIR PE=1 SV=3,0,12.38,15,3,14,3,311,33.9,6.95,6174,,3,,,membrane,protein binding,,64115,ENSG00000107738.19,C10orf54; VSIR,10,,,,0,High,1
Q9BQG2,Peroxisomal NADH pyrophosphatase NUDT12 OS=Homo sapiens OX=9606 GN=NUDT12 PE=1 SV=1,0,12.37,6,3,5,3,462,52,6.83,1860,,3,,metabolic process,cytoplasm;nucleus;organelle lumen,catalytic activity;metal ion binding;protein binding,"Pf00023, Pf00293, Pf09297, Pf12796, Pf13606, Pf13637, Pf13857",83594,ENSG00000112874.9,NUDT12,5,Metabolic pathways; Peroxisome; Nicotinate and nicotinamide metabolism,,Nicotinamide salvaging,8,High,1
O14613,Cdc42 effector protein 2 OS=Homo sapiens OX=9606 GN=CDC42EP2 PE=1 SV=1,0,12.361,30,3,5,3,210,22.5,5.12,1596,,3,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane,enzyme regulator activity;protein binding,"Pf00786, Pf14957",10435,ENSG00000149798.4,CDC42EP2,11,,,MAPK6/MAPK4 signaling,3,High,1
P58340,Myeloid leukemia factor 1 OS=Homo sapiens OX=9606 GN=MLF1 PE=1 SV=1,0,12.36,11,2,9,2,268,30.6,9.45,4517,,2,,cell differentiation;development;metabolic process;regulation of biological process,cytoplasm;nucleus,DNA binding;protein binding,Pf10248,4291,ENSG00000178053.17,MLF1,3,Transcriptional misregulation in cancer,,,1,High,1
Q6ZT21,Transmembrane protein with metallophosphoesterase domain OS=Homo sapiens OX=9606 GN=TMPPE PE=2 SV=2,0,12.36,6,2,5,2,453,49.4,6.92,3093,,2,,,membrane,catalytic activity;metal ion binding,Pf00149,643853,ENSG00000188167.8,TMPPE,3,,,,0,High,1
O96033,Molybdopterin synthase sulfur carrier subunit OS=Homo sapiens OX=9606 GN=MOCS2 PE=1 SV=1,0,12.349,31,3,14,3,88,9.7,4.72,5964,,3,,metabolic process,cytoplasm;cytosol;nucleus,catalytic activity;nucleotide binding,Pf02597,4338,ENSG00000164172.18,MOCS2,5,,,Molybdenum cofactor biosynthesis,4,High,1
Q9UBJ2,ATP-binding cassette sub-family D member 2 OS=Homo sapiens OX=9606 GN=ABCD2 PE=1 SV=1,0,12.347,5,3,7,2,740,83.2,8.92,1411,2.61,2,1,metabolic process;regulation of biological process;transport,cytosol;membrane,catalytic activity;nucleotide binding;protein binding;transporter activity,"Pf00005, Pf06472",225,ENSG00000173208.3,ABCD2,12,ABC transporters; Peroxisome,Nuclear Receptors in Lipid Metabolism and Toxicity,ABC transporters in lipid homeostasis,6,High,1
Q9NYJ8,TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 OS=Homo sapiens OX=9606 GN=TAB2 PE=1 SV=1,0,12.338,3,2,5,2,693,76.4,8.54,2943,,2,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,metal ion binding;protein binding,"Pf00641, Pf02845, Pf13863",23118,ENSG00000055208.18,TAB2,6,Toxoplasmosis; Osteoclast differentiation; Toll-like receptor signaling pathway; MAPK signaling pathway; TNF signaling pathway; Epstein-Barr virus infection; Herpes simplex infection; NOD-like receptor signaling pathway; Measles; NF-kappa B signaling pathway; Leishmaniasis,Regulation of toll-like receptor signaling pathway; IL-1 signaling pathway; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; TNF alpha Signaling Pathway; Structural Pathway of Interleukin 1 (IL-1); MAPK Signaling Pathway; TLR4 Signaling and Tolerance; Exercise-induced Circadian Regulation; Toll-like receptor signaling pathway,"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Downstream TCR signaling; NOD1/2 Signaling Pathway; IRAK2 mediated activation of TAK1 complex; TRAF6-mediated induction of TAK1 complex within TLR4 complex; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; TNFR1-induced NFkappaB signaling pathway; FCERI mediated NF-kB activation; Activated TLR4 signalling; Interleukin-1 family signaling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; activated TAK1 mediates p38 MAPK activation; Nuclear signaling by ERBB4; TICAM1,TRAF6-dependent induction of TAK1 complex; CLEC7A (Dectin-1) signaling",67,High,1
O94967,WD repeat-containing protein 47 OS=Homo sapiens OX=9606 GN=WDR47 PE=1 SV=1,0,12.334,3,3,10,3,919,101.9,5.94,3119,,3,,development,cytoplasm;cytoskeleton,protein binding,Pf00400,22911,ENSG00000085433.15,WDR47,1,,,,0,High,1
Q96IK1,Biorientation of chromosomes in cell division protein 1 OS=Homo sapiens OX=9606 GN=BOD1 PE=1 SV=2,0,12.331,22,4,12,3,185,19.2,6.33,3618,,4,,cell division,chromosome;cytoplasm;cytoskeleton,,Pf05205,91272,ENSG00000145919.10,BOD1,5,,,,0,High,1
Q5TGZ0,MICOS complex subunit MIC10 OS=Homo sapiens OX=9606 GN=MICOS10 PE=1 SV=1,0,12.328,41,1,2,1,78,8.8,8.5,,4.41,,1,,membrane;mitochondrion,protein binding,Pf04418,440574,ENSG00000173436.13,MINOS1,1,,,Cristae formation,3,High,1
P30520,Adenylosuccinate synthetase isozyme 2 OS=Homo sapiens OX=9606 GN=ADSS2 PE=1 SV=3,0,12.322,10,3,11,2,456,50.1,6.55,4323,,3,,metabolic process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding,Pf00709,159,ENSG00000035687.9,ADSS,1,"Purine metabolism; Metabolic pathways; Alanine, aspartate and glutamate metabolism",Nucleotide Metabolism,Purine ribonucleoside monophosphate biosynthesis,8,High,1
Q9UHP3,Ubiquitin carboxyl-terminal hydrolase 25 OS=Homo sapiens OX=9606 GN=USP25 PE=1 SV=4,0,12.298,3,3,16,2,1055,122.1,5.34,6061,,3,,metabolic process,cytoplasm;cytosol;endoplasmic reticulum;nucleus,catalytic activity;protein binding,"Pf00443, Pf13423",29761,ENSG00000155313.15,USP25,21,,,Ub-specific processing proteases,4,High,1
O75976,Carboxypeptidase D OS=Homo sapiens OX=9606 GN=CPD PE=1 SV=2,0,12.295,2,3,6,3,1380,152.8,6.05,2957,,3,,metabolic process,membrane,catalytic activity;metal ion binding,"Pf00246, Pf04952, Pf13620, Pf13715",1362,ENSG00000108582.11,CPD,17,,,Golgi Associated Vesicle Biogenesis,5,High,1
Q8IWV8,E3 ubiquitin-protein ligase UBR2 OS=Homo sapiens OX=9606 GN=UBR2 PE=1 SV=1,0,12.294,3,4,8,4,1755,200.4,6.24,2516,,4,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;protein binding,"Pf02207, Pf02617",23304,ENSG00000024048.10,UBR2,6,,,Antigen processing: Ubiquitination & Proteasome degradation,4,High,1
Q30201,Hereditary hemochromatosis protein OS=Homo sapiens OX=9606 GN=HFE PE=1 SV=1,0,12.286,4,1,12,1,348,40.1,6.6,5988,,1,,cell communication;cell organization and biogenesis;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoskeleton;endosome;membrane,protein binding,"Pf00129, Pf07654",3077,ENSG00000010704.18,HFE,6,,Hfe effect on hepcidin production,Transferrin endocytosis and recycling,4,High,1
Q9UJX4,Anaphase-promoting complex subunit 5 OS=Homo sapiens OX=9606 GN=ANAPC5 PE=1 SV=2,0,12.286,5,2,4,2,755,85,6.87,1832,,2,,cell division;metabolic process;regulation of biological process,cytosol;nucleus,protein binding,Pf12862,51433,ENSG00000089053.12,ANAPC5,12,Cell cycle; Ubiquitin mediated proteolysis; HTLV-I infection; Oocyte meiosis; Progesterone-mediated oocyte maturation,,APC/C:Cdc20 mediated degradation of Cyclin B; Inactivation of APC/C via direct inhibition of the APC/C complex; Autodegradation of Cdh1 by Cdh1:APC/C; APC-Cdc20 mediated degradation of Nek2A; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Antigen processing: Ubiquitination & Proteasome degradation; Phosphorylation of the APC/C; APC/C:Cdc20 mediated degradation of Securin; Separation of Sister Chromatids; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Senescence-Associated Secretory Phenotype (SASP),37,High,1
P51606,N-acylglucosamine 2-epimerase OS=Homo sapiens OX=9606 GN=RENBP PE=1 SV=2,0,12.284,7,2,7,2,427,48.8,6.37,3598,,2,,metabolic process;regulation of biological process,cytosol,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding,Pf07221,5973,ENSG00000102032.12,RENBP,X,Amino sugar and nucleotide sugar metabolism,,Synthesis of UDP-N-acetyl-glucosamine,7,High,1
Q96FS4,Signal-induced proliferation-associated protein 1 OS=Homo sapiens OX=9606 GN=SIPA1 PE=1 SV=1,0,12.279,4,4,9,4,1042,112.1,6.6,3735,,4,,cell communication;cell organization and biogenesis;cell proliferation;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,catalytic activity;enzyme regulator activity;motor activity;protein binding,"Pf00595, Pf01576, Pf02145, Pf03980, Pf09755, Pf12795, Pf13949",6494,ENSG00000213445.9,SIPA1,11,Rap1 signaling pathway; Leukocyte transendothelial migration,MAPK Cascade,Rap1 signalling,6,High,1
Q7Z6B7,SLIT-ROBO Rho GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=SRGAP1 PE=1 SV=1,0,12.274,2,2,6,1,1085,124.2,6.83,3789,,2,,regulation of biological process;response to stimulus,cytoplasm;cytosol,enzyme regulator activity;protein binding,"Pf00018, Pf00611, Pf00620, Pf07653, Pf14604",57522,ENSG00000196935.8,SRGAP1,12,Axon guidance,,Inactivation of CDC42 and RAC1; Rho GTPase cycle,8,High,1
Q9UKD2,mRNA turnover protein 4 homolog OS=Homo sapiens OX=9606 GN=MRTO4 PE=1 SV=2,0,12.269,26,5,10,5,239,27.5,8.29,3602,,5,,cell organization and biogenesis;metabolic process,cytoplasm;nucleus,protein binding;RNA binding,Pf00466,51154,ENSG00000053372.4,MRTO4,1,,,,0,High,1
Q8TBQ9,Protein kish-A OS=Homo sapiens OX=9606 GN=TMEM167A PE=1 SV=1,0.001,12.219,25,2,32,2,72,8.1,8.95,15323,,2,,transport,Golgi;membrane,,Pf06842,153339,ENSG00000174695.9,TMEM167A,5,,,,0,High,1
Q6UW78,Ubiquinol-cytochrome-c reductase complex assembly factor 3 OS=Homo sapiens OX=9606 GN=UQCC3 PE=1 SV=2,0.001,12.217,32,2,13,2,93,10.1,9.41,6065,,2,,cell organization and biogenesis;metabolic process,membrane;mitochondrion,,Pf15141,790955,ENSG00000204922.4,C11orf83; UQCC3,11,,,,0,High,1
P01714,Immunoglobulin lambda variable 3-19 OS=Homo sapiens OX=9606 GN=IGLV3-19 PE=1 SV=2,0.001,12.215,16,1,11,1,112,12,4.96,4735,,1,,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity,"Pf07679, Pf07686",28797,ENSG00000211663.2,IGLV3-19,22,,,FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis,26,High,1
Q8WV41,Sorting nexin-33 OS=Homo sapiens OX=9606 GN=SNX33 PE=1 SV=1,0.001,12.211,11,5,11,5,574,65.2,6.79,2884,,5,,cell division;cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytosol;membrane,protein binding,"Pf00018, Pf00787, Pf07653, Pf10456, Pf14604",257364,ENSG00000173548.8,SNX33,15,,,,0,High,1
O43505,"Beta-1,4-glucuronyltransferase 1 OS=Homo sapiens OX=9606 GN=B4GAT1 PE=1 SV=1",0.001,12.194,9,3,9,3,415,47.1,7.2,4004,,3,,cellular component movement;metabolic process,Golgi;membrane,catalytic activity;metal ion binding;protein binding,Pf13896,11041,ENSG00000174684.6,B3GNT1; B4GAT1,11,Metabolic pathways; Glycosphingolipid biosynthesis - lacto and neolacto series; Glycosaminoglycan biosynthesis - keratan sulfate,,Keratan sulfate biosynthesis; O-linked glycosylation,11,High,1
Q969X1,Protein lifeguard 3 OS=Homo sapiens OX=9606 GN=TMBIM1 PE=1 SV=2,0.001,12.168,5,2,7,2,311,34.6,7.72,3220,,2,,regulation of biological process;transport,endosome;Golgi;membrane;vacuole,protein binding,Pf01027,64114,ENSG00000135926.14,TMBIM1,2,,,Neutrophil degranulation,3,High,1
Q13574,Diacylglycerol kinase zeta OS=Homo sapiens OX=9606 GN=DGKZ PE=1 SV=3,0.001,12.157,4,3,8,2,1117,124.1,9.04,2592,,3,,cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;membrane;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00023, Pf00130, Pf00609, Pf00781, Pf12796, Pf13637, Pf13857",8525,ENSG00000149091.15,DGKZ,11,Phospholipase D signaling pathway; Choline metabolism in cancer; Metabolic pathways; Glycerolipid metabolism; Glycerophospholipid metabolism; Phosphatidylinositol signaling system,Myometrial Relaxation and Contraction Pathways; Leptin Insulin Overlap,Effects of PIP2 hydrolysis; Gastrin-CREB signalling pathway via PKC and MAPK,16,High,1
Q13835,Plakophilin-1 OS=Homo sapiens OX=9606 GN=PKP1 PE=1 SV=2,0.001,12.143,4,2,8,2,747,82.8,9.13,4040,,2,,cell death;cell organization and biogenesis;development;regulation of biological process;response to stimulus;transport,cytoskeleton;membrane;nucleus,protein binding;signal transducer activity;structural molecule activity,Pf00514,5317,ENSG00000081277.12,PKP1,1,,,Apoptotic cleavage of cell adhesion  proteins; Formation of the cornified envelope; Neutrophil degranulation,11,High,1
P45983,Mitogen-activated protein kinase 8 OS=Homo sapiens OX=9606 GN=MAPK8 PE=1 SV=2,0.001,12.135,10,4,81,2,427,48.3,6.89,38261,,4,,cell communication;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;mitochondrion;nucleus,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf01636, Pf07714, Pf14531",5599,ENSG00000107643.15,MAPK8,10,MAPK signaling pathway; Insulin resistance; Osteoclast differentiation; Inflammatory mediator regulation of TRP channels; Focal adhesion; Protein processing in endoplasmic reticulum; Prolactin signaling pathway; GnRH signaling pathway; Chagas disease (American trypanosomiasis); Sphingolipid signaling pathway; HTLV-I infection; Colorectal cancer; Adipocytokine signaling pathway; Hepatitis B; Hepatitis C; Choline metabolism in cancer; Apoptosis - multiple species; Epstein-Barr virus infection; Epithelial cell signaling in Helicobacter pylori infection; Th1 and Th2 cell differentiation; Toll-like receptor signaling pathway; Toxoplasmosis; Type II diabetes mellitus; Shigellosis; Insulin signaling pathway; Ras signaling pathway; Salmonella infection; AGE-RAGE signaling pathway in diabetic complications; Neurotrophin signaling pathway; cAMP signaling pathway; TNF signaling pathway; Herpes simplex infection; Apoptosis; ErbB signaling pathway; Pancreatic cancer; Endocrine resistance; Retrograde endocannabinoid signaling; Tuberculosis; Progesterone-mediated oocyte maturation; Influenza A; NOD-like receptor signaling pathway; Fc epsilon RI signaling pathway; Wnt signaling pathway; Pathways in cancer; FoxO signaling pathway; RIG-I-like receptor signaling pathway; Dopaminergic synapse; Non-alcoholic fatty liver disease (NAFLD); Pertussis,Osteoclast Signaling; Regulation of toll-like receptor signaling pathway; Physiological and Pathological Hypertrophy  of the Heart; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; IL-1 signaling pathway; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; Leptin signaling pathway; TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway; Prolactin Signaling Pathway; B Cell Receptor Signaling Pathway; TNF alpha Signaling Pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Nanoparticle triggered regulated necrosis; EBV LMP1 signaling; Cardiac Hypertrophic Response; IL-3 Signaling Pathway; NLR Proteins; Transcriptional activation by NRF2; Kit receptor signaling pathway; Focal Adhesion; Signaling of Hepatocyte Growth Factor Receptor; Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation; Rac1/Pak1/p38/MMP-2 pathway; Transcription factor regulation in adipogenesis; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Wnt Signaling Pathway Netpath; Hepatitis C and Hepatocellular Carcinoma; TGF-beta Signaling Pathway; Hypothesized Pathways in Pathogenesis of Cardiovascular Disease; Association Between Physico-Chemical Features and Toxicity Associated Pathways; MAPK Signaling Pathway; RIG-I-like Receptor Signaling; Canonical and Non-Canonical TGF-B signaling; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; Wnt Signaling in Kidney Disease; EGF/EGFR Signaling Pathway; Insulin Signaling; ErbB Signaling Pathway; T-Cell antigen Receptor (TCR)  Signaling Pathway; DNA Damage Response (only ATM dependent); Toll-like receptor signaling pathway,FCERI mediated MAPK activation; Activation of BMF and translocation to mitochondria; Activated TLR4 signalling; NRAGE signals death through JNK; Activation of the AP-1 family of transcription factors; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Activation of BIM and translocation to mitochondria ; NRIF signals cell death from the nucleus; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; DSCAM interactions; Signalling by NGF; Interleukin-38 signaling; Oxidative Stress Induced Senescence,150,High,1
P48651,Phosphatidylserine synthase 1 OS=Homo sapiens OX=9606 GN=PTDSS1 PE=1 SV=1,0.001,12.121,6,2,8,2,473,55.5,8.43,3605,,2,,metabolic process,endoplasmic reticulum;membrane,catalytic activity,Pf03034,9791,ENSG00000156471.12,PTDSS1,8,Glycerophospholipid metabolism; Metabolic pathways,Kennedy pathway,Synthesis of PS,8,High,1
Q9HC07,Transmembrane protein 165 OS=Homo sapiens OX=9606 GN=TMEM165 PE=1 SV=1,0.001,12.102,14,2,3,2,324,34.9,7.02,1123,,2,,cellular homeostasis;metabolic process;transport,endosome;Golgi;membrane;vacuole,,Pf01169,55858,ENSG00000134851.12,TMEM165,4,,,,0,High,1
Q9UI14,Prenylated Rab acceptor protein 1 OS=Homo sapiens OX=9606 GN=RABAC1 PE=1 SV=1,0.001,12.093,16,2,9,2,185,20.6,7.34,4223,,2,,,cytoplasm;Golgi;membrane,protein binding,Pf03208,10567,ENSG00000105404.10,RABAC1,19,,,,0,High,1
O15519,CASP8 and FADD-like apoptosis regulator OS=Homo sapiens OX=9606 GN=CFLAR PE=1 SV=1,0.001,12.087,5,2,6,2,480,55.3,8,3817,,2,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;enzyme regulator activity;protein binding,"Pf00656, Pf01335",8837,ENSG00000003402.19,CFLAR,2,NF-kappa B signaling pathway; TNF signaling pathway; Apoptosis; Chagas disease (American trypanosomiasis),TNF alpha Signaling Pathway; Nanomaterial induced apoptosis; Apoptosis; Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation; Photodynamic therapy-induced NF-kB survival signaling,Regulation by c-FLIP; CASP8 activity is inhibited; TRAIL  signaling,21,High,1
P35568,Insulin receptor substrate 1 OS=Homo sapiens OX=9606 GN=IRS1 PE=1 SV=1,0.001,12.083,5,4,30,4,1242,131.5,8.54,11533,,4,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,catalytic activity;protein binding;signal transducer activity,"Pf00169, Pf02174",3667,ENSG00000169047.5,IRS1,2,mTOR signaling pathway; Neurotrophin signaling pathway; FoxO signaling pathway; Adipocytokine signaling pathway; Non-alcoholic fatty liver disease (NAFLD); AMPK signaling pathway; cGMP-PKG signaling pathway; PI3K-Akt signaling pathway; Insulin signaling pathway; Insulin resistance; Aldosterone-regulated sodium reabsorption; Type II diabetes mellitus; MicroRNAs in cancer; Longevity regulating pathway - multiple species; Longevity regulating pathway; Regulation of lipolysis in adipocytes,Type II diabetes mellitus; Integrated Breast Cancer Pathway; Leptin signaling pathway; Prolactin Signaling Pathway; Signaling Pathways in Glioblastoma; AGE/RAGE pathway; Adipogenesis; Oncostatin M Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Alpha 6 Beta 4 signaling pathway; Transcription factor regulation in adipogenesis; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Angiopoietin Like Protein 8 Regulatory Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Leptin Insulin Overlap; IL-4 Signaling Pathway; Insulin Signaling; EPO Receptor Signaling; Interferon type I signaling pathways; DNA Damage Response (only ATM dependent),"PI3K Cascade; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Signaling by Leptin; IRS activation; Interleukin-7 signaling; PI3K/AKT activation; Signal attenuation; Constitutive Signaling by Aberrant PI3K in Cancer; SOS-mediated signalling; Growth hormone receptor signaling; RAF/MAP kinase cascade; Interleukin-20 family signaling",69,High,1
O94888,UBX domain-containing protein 7 OS=Homo sapiens OX=9606 GN=UBXN7 PE=1 SV=2,0.001,12.07,5,2,8,2,489,54.8,5.16,4423,,2,,metabolic process,cytosol;nucleus,protein binding,"Pf00789, Pf13899, Pf14555",26043,ENSG00000163960.11,UBXN7,3,,,Neddylation,3,High,1
Q9BYV8,Centrosomal protein of 41 kDa OS=Homo sapiens OX=9606 GN=CEP41 PE=1 SV=1,0.001,12.069,9,2,2,2,373,41.3,8.32,1217,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;membrane,protein binding,Pf00581,95681,ENSG00000106477.18,CEP41,7,,,Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes,16,High,1
O94856,Neurofascin OS=Homo sapiens OX=9606 GN=NFASC PE=1 SV=4,0.001,12.061,3,4,9,4,1347,149.9,6.65,3340,,4,,cell organization and biogenesis;cellular component movement;transport,membrane,protein binding,"Pf00041, Pf00047, Pf07679, Pf07686, Pf13882, Pf13895, Pf13927",23114,,NFASC,1,Cell adhesion molecules (CAMs),,Neutrophil degranulation; Neurofascin interactions; Interaction between L1 and Ankyrins,9,High,1
Q9BY67,Cell adhesion molecule 1 OS=Homo sapiens OX=9606 GN=CADM1 PE=1 SV=2,0.001,12.06,9,2,7,2,442,48.5,5.07,2429,,2,,cell death;cell differentiation;cell organization and biogenesis;cell proliferation;development;regulation of biological process;response to stimulus,membrane,protein binding;receptor activity,"Pf00047, Pf07679, Pf07686, Pf08205, Pf13895, Pf13927",23705,ENSG00000182985.17,CADM1,11,Cell adhesion molecules (CAMs),,Nectin/Necl  trans heterodimerization,6,High,1
Q13546,Receptor-interacting serine/threonine-protein kinase 1 OS=Homo sapiens OX=9606 GN=RIPK1 PE=1 SV=3,0.001,12.058,9,4,5,4,671,75.9,6.33,1669,,4,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf00531, Pf07714, Pf12721",8737,ENSG00000137275.13,RIPK1,6,Hepatitis C; Apoptosis; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; Epstein-Barr virus infection; Toll-like receptor signaling pathway; NF-kappa B signaling pathway; TNF signaling pathway,Regulation of toll-like receptor signaling pathway; Apoptosis Modulation and Signaling; TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway; TNF alpha Signaling Pathway; Nanoparticle triggered regulated necrosis; Apoptosis; Apoptosis Modulation by HSP70; RIG-I-like Receptor Signaling; p38 MAPK Signaling Pathway; Toll-like receptor signaling pathway,"TLR3-mediated TICAM1-dependent programmed cell death; Ub-specific processing proteases; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; TNFR1-induced proapoptotic signaling; IKK complex recruitment mediated by RIP1; TICAM1, RIP1-mediated IKK complex recruitment ; TRP channels; Ovarian tumor domain proteases; TNFR1-induced NFkappaB signaling pathway; RIP-mediated NFkB activation via ZBP1; Activated TLR4 signalling; Dimerization of procaspase-8; TRIF-mediated programmed cell death; Regulation of TNFR1 signaling; Regulation by c-FLIP; CASP8 activity is inhibited",61,High,1
Q14137,Ribosome biogenesis protein BOP1 OS=Homo sapiens OX=9606 GN=BOP1 PE=1 SV=2,0.001,12.056,5,3,5,3,746,83.6,6.19,2091,,3,,cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process,nucleus,protein binding;RNA binding,"Pf00400, Pf08145",23246,ENSG00000261236.7,BOP1,8,,,Major pathway of rRNA processing in the nucleolus and cytosol,4,High,1
P04180,Phosphatidylcholine-sterol acyltransferase OS=Homo sapiens OX=9606 GN=LCAT PE=1 SV=1,0.001,12.045,7,2,4,2,440,49.5,6.11,2755,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,extracellular,catalytic activity;protein binding,"Pf02450, Pf06821, Pf12697",3931,ENSG00000213398.7,LCAT,16,Glycerophospholipid metabolism,Composition of Lipid Particles; Statin Pathway,HDL remodeling,7,High,1
Q8IY67,Ribonucleoprotein PTB-binding 1 OS=Homo sapiens OX=9606 GN=RAVER1 PE=1 SV=1,0.001,12.042,6,2,5,2,606,63.8,8.48,2063,,2,,metabolic process,cytoplasm;nucleus,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",125950,ENSG00000161847.13,RAVER1,19,,,,0,High,1
Q7Z417,Nuclear fragile X mental retardation-interacting protein 2 OS=Homo sapiens OX=9606 GN=NUFIP2 PE=1 SV=1,0.001,12.041,7,3,6,3,695,76.1,8.7,2439,,3,,,cytoplasm;cytosol;membrane;nucleus;ribosome,protein binding;RNA binding,Pf15293,57532,ENSG00000108256.8,NUFIP2,17,,,,0,High,1
Q9H6L5,Reticulophagy regulator 1 OS=Homo sapiens OX=9606 GN=RETREG1 PE=1 SV=1,0.001,12.032,6,3,17,3,497,54.6,4.63,5207,,3,,metabolic process;regulation of biological process,endoplasmic reticulum;Golgi;membrane,protein binding,,54463,ENSG00000154153.13,FAM134B; RETREG1,5,,,,0,High,1
Q96RN5,Mediator of RNA polymerase II transcription subunit 15 OS=Homo sapiens OX=9606 GN=MED15 PE=1 SV=2,0.001,12.029,4,2,9,2,788,86.7,9.42,3807,,2,,metabolic process;regulation of biological process,cytoplasm;membrane;nucleus,protein binding,Pf09606,51586,ENSG00000099917.17,MED15,22,,Sterol Regulatory Element-Binding Proteins (SREBP) signalling; SREBF and miR33 in cholesterol and lipid homeostasis,Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway,11,High,1
P35240,Merlin OS=Homo sapiens OX=9606 GN=NF2 PE=1 SV=1,0.001,12.019,2,2,136,1,595,69.6,6.47,66953,0,2,1,cell differentiation;cell organization and biogenesis;cell proliferation;regulation of biological process,cytoplasm;cytoskeleton;cytosol;endosome;membrane;nucleus,protein binding,"Pf00373, Pf00769, Pf09379, Pf09380",4771,ENSG00000186575.17,NF2,22,Hippo signaling pathway -multiple species; Hippo signaling pathway,Ectoderm Differentiation,RHO GTPases activate PAKs; Regulation of actin dynamics for phagocytic cup formation,11,High,1
A0A0C4DH34,Immunoglobulin heavy variable 4-28 OS=Homo sapiens OX=9606 GN=IGHV4-28 PE=3 SV=1,0.001,12.018,15,2,29,1,117,13.1,9.29,11883,,2,,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,protein binding,,28400,ENSG00000282726.1; ENSG00000211952.3,IGHV4-28,14; CHR_HSCHR14_3_CTG1,,,,0,High,1
Q8TDB6,E3 ubiquitin-protein ligase DTX3L OS=Homo sapiens OX=9606 GN=DTX3L PE=1 SV=1,0.001,12.005,5,3,8,3,740,83.5,8.06,3137,,3,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;nucleus;vacuole,catalytic activity;enzyme regulator activity;metal ion binding;protein binding;RNA binding,"Pf00097, Pf13639, Pf13920, Pf13923, Pf14634, Pf14835",151636,ENSG00000163840.9,DTX3L,3,Notch signaling pathway,Notch Signaling Pathway,Antigen processing: Ubiquitination & Proteasome degradation,6,High,1
Q8ND56,Protein LSM14 homolog A OS=Homo sapiens OX=9606 GN=LSM14A PE=1 SV=3,0.001,11.997,9,3,6,3,463,50.5,9.52,2032,,3,,cell organization and biogenesis;defense response;development;regulation of biological process;response to stimulus,cytoplasm;cytosol,DNA binding;RNA binding,"Pf09532, Pf12701, Pf14438",26065,ENSG00000262860.5; ENSG00000257103.8,LSM14A,19; CHR_HSCHR19_1_CTG3_1,,,,0,High,1
Q9P2K8,eIF-2-alpha kinase GCN2 OS=Homo sapiens OX=9606 GN=EIF2AK4 PE=1 SV=3,0.001,11.991,3,4,9,4,1649,186.8,6.28,3338,,4,,cell communication;cell growth;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;ribosome,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00069, Pf00587, Pf05773, Pf07714, Pf12745",440275,ENSG00000128829.11,EIF2AK4,15,Hepatitis C; Epstein-Barr virus infection; Measles; Influenza A; Herpes simplex infection; Protein processing in endoplasmic reticulum,,,6,High,1
Q96JM3,Chromosome alignment-maintaining phosphoprotein 1 OS=Homo sapiens OX=9606 GN=CHAMP1 PE=1 SV=2,0.001,11.962,2,2,8,2,812,89,8.44,4281,,2,,cell organization and biogenesis,chromosome;cytoplasm;cytoskeleton;nucleus,metal ion binding;protein binding,Pf00096,283489,ENSG00000198824.5,CHAMP1,13,,,,0,High,1
Q86WA8,"Lon protease homolog 2, peroxisomal OS=Homo sapiens OX=9606 GN=LONP2 PE=1 SV=1",0.001,11.962,4,2,9,2,852,94.6,7.3,3997,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;membrane;nucleus;organelle lumen,catalytic activity;nucleotide binding;protein binding,"Pf00004, Pf01202, Pf02190, Pf05362, Pf07726, Pf07728, Pf13191, Pf13541",83752,ENSG00000102910.13,LONP2,16,,,Association of TriC/CCT with target proteins during biosynthesis,4,High,1
Q14919,Dr1-associated corepressor OS=Homo sapiens OX=9606 GN=DRAP1 PE=1 SV=3,0.001,11.955,11,2,16,2,205,22.3,5.17,7867,,2,,metabolic process;regulation of biological process,nucleus,DNA binding;protein binding,"Pf00125, Pf00808",10589,ENSG00000175550.7,DRAP1,11,,,Signaling by NODAL; Signaling by Activin,5,High,1
Q6NUQ4,Transmembrane protein 214 OS=Homo sapiens OX=9606 GN=TMEM214 PE=1 SV=2,0.001,11.947,7,3,9,3,689,77.1,9.14,3602,,3,,cell death,cytosol;endoplasmic reticulum;Golgi;membrane,,Pf10151,54867,ENSG00000119777.18,TMEM214,2,,,,0,High,1
Q16637,Survival motor neuron protein OS=Homo sapiens OX=9606 GN=SMN1 PE=1 SV=1,0.001,11.941,6,1,11,1,294,31.8,6.55,4651,,1,,cell organization and biogenesis;cellular component movement;metabolic process;response to stimulus;transport,cytoplasm;cytosol;nucleus,protein binding;RNA binding;transporter activity,Pf06003,6606; 6607,ENSG00000205571.13; ENSG00000273772.4; ENSG00000277773.4; ENSG00000172062.16; ENSG00000275349.4,SMN1; SMN2,5; CHR_HSCHR5_1_CTG1_1; CHR_HSCHR5_2_CTG1_1,RNA transport,,snRNP Assembly,4,High,1
P37173,TGF-beta receptor type-2 OS=Homo sapiens OX=9606 GN=TGFBR2 PE=1 SV=2,0.001,11.94,7,3,6,3,567,64.5,5.9,2450,,3,,cell death;cell differentiation;cell growth;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;cytosol;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding;receptor activity;signal transducer activity,"Pf00069, Pf07714, Pf08917",7048,ENSG00000163513.17,TGFBR2,3,Adherens junction; Pancreatic cancer; AGE-RAGE signaling pathway in diabetic complications; Endocytosis; MAPK signaling pathway; Chronic myeloid leukemia; Transcriptional misregulation in cancer; Osteoclast differentiation; Pathways in cancer; Chagas disease (American trypanosomiasis); Hippo signaling pathway; FoxO signaling pathway; TGF-beta signaling pathway; HTLV-I infection; Colorectal cancer; Cytokine-cytokine receptor interaction,Extracellular vesicle-mediated signaling in recipient cells; NRF2 pathway; TGF-beta Signaling Pathway; Hypothesized Pathways in Pathogenesis of Cardiovascular Disease; MAPK Signaling Pathway; Canonical and Non-Canonical TGF-B signaling; TGF-beta Receptor Signaling,SMAD2/3 Phosphorylation Motif Mutants in Cancer; TGFBR2 Kinase Domain Mutants in Cancer; TGFBR1 LBD Mutants in Cancer; UCH proteinases; Downregulation of TGF-beta receptor signaling; TGFBR2 MSI Frameshift Mutants in Cancer; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); SMAD2/3 MH2 Domain Mutants in Cancer; TGFBR1 KD Mutants in Cancer,45,High,1
Q6AI08,HEAT repeat-containing protein 6 OS=Homo sapiens OX=9606 GN=HEATR6 PE=1 SV=1,0.001,11.926,3,3,5,3,1181,128.7,7.03,2228,,3,,transport,,RNA binding;transporter activity,"Pf13251, Pf13513, Pf13646",63897,ENSG00000068097.14,HEATR6,17,,,,0,High,1
Q8TCY9,Up-regulator of cell proliferation OS=Homo sapiens OX=9606 GN=URGCP PE=1 SV=2,0.001,11.925,2,2,7,2,931,104.9,6.42,3403,,2,,,cytoplasm;cytosol;nucleus,nucleotide binding,Pf04312,55665,ENSG00000106608.16,URGCP,7,,,,0,High,1
Q6STE5,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 OS=Homo sapiens OX=9606 GN=SMARCD3 PE=1 SV=1,0.001,11.919,6,3,10,3,483,55,9.35,4657,,3,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;nucleus,protein binding,Pf02201,6604,ENSG00000082014.16,SMARCD3,7,,,"Transcriptional regulation of white adipocyte differentiation; RMTs methylate histone arginines; Activation of gene expression by SREBF (SREBP); RORA activates gene expression; PPARA activates gene expression; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; YAP1- and WWTR1 (TAZ)-stimulated gene expression; Transcriptional activation of mitochondrial biogenesis; BMAL1:CLOCK,NPAS2 activates circadian gene expression; RUNX3 regulates YAP1-mediated transcription",26,High,1
Q12797-3,Isoform 3 of Aspartyl/asparaginyl beta-hydroxylase OS=Homo sapiens OX=9606 GN=ASPH,0.001,11.915,13,2,47,1,225,25.5,9.61,6590,59.8,1,1,metabolic process;regulation of biological process;transport,endoplasmic reticulum;membrane,catalytic activity;metal ion binding;protein binding;structural molecule activity,Pf05279,444,ENSG00000198363.17,ASPH,8,,,,0,High,1
Q6P4A8,Phospholipase B-like 1 OS=Homo sapiens OX=9606 GN=PLBD1 PE=1 SV=2,0.001,11.91,8,3,6,3,553,63.2,9.06,2308,,3,,metabolic process,cytosol;vacuole,catalytic activity,Pf04916,79887,ENSG00000121316.10,PLBD1,12,,,Acyl chain remodelling of PI; Hydrolysis of LPC; Acyl chain remodelling of PE; Acyl chain remodelling of PC,8,High,1
O15397,Importin-8 OS=Homo sapiens OX=9606 GN=IPO8 PE=1 SV=2,0.001,11.902,4,3,5,3,1037,119.9,5.16,2366,,3,,regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus,protein binding;transporter activity,"Pf03810, Pf08506",10526,ENSG00000133704.9,IPO8,12,,,Transcriptional regulation by small RNAs,3,High,1
P41223,Protein BUD31 homolog OS=Homo sapiens OX=9606 GN=BUD31 PE=1 SV=2,0.001,11.901,12,2,20,2,144,17,8.82,10103,,2,,cell organization and biogenesis;metabolic process;regulation of biological process,nucleus;spliceosomal complex,catalytic activity;protein binding,Pf01125,8896,ENSG00000106245.10,BUD31,7,Spliceosome,,mRNA Splicing - Major Pathway,5,High,1
Q16787,Laminin subunit alpha-3 OS=Homo sapiens OX=9606 GN=LAMA3 PE=1 SV=2,0.001,11.894,2,3,22,1,3333,366.4,7.24,9132,,3,,cell differentiation;cell organization and biogenesis;cellular component movement;regulation of biological process;transport,extracellular,catalytic activity;motor activity;protein binding;structural molecule activity,"Pf00038, Pf00052, Pf00053, Pf00054, Pf00055, Pf01576, Pf02210, Pf03938, Pf05557, Pf06008, Pf06009, Pf06873, Pf07888, Pf07926, Pf10174, Pf11985, Pf12795, Pf13385, Pf13851",3909,,LAMA3,18,Toxoplasmosis; PI3K-Akt signaling pathway; Focal adhesion; Small cell lung cancer; Amoebiasis; ECM-receptor interaction; Pathways in cancer; Metabolic pathways,Alpha 6 Beta 4 signaling pathway; Focal Adhesion; Overview of nanoparticle effects; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,ECM proteoglycans; Laminin interactions; Degradation of the extracellular matrix; MET activates PTK2 signaling; Type I hemidesmosome assembly; Anchoring fibril formation; Non-integrin membrane-ECM interactions,28,High,1
Q9C0J8,pre-mRNA 3' end processing protein WDR33 OS=Homo sapiens OX=9606 GN=WDR33 PE=1 SV=2,0.001,11.891,5,3,8,3,1336,145.8,9.17,1886,,3,,metabolic process;response to stimulus;transport,nucleus,protein binding;RNA binding,Pf00400,55339,ENSG00000136709.11,WDR33,2,mRNA surveillance pathway,,mRNA 3'-end processing; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA Splicing - Major Pathway; Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs,15,High,1
P55854,Small ubiquitin-related modifier 3 OS=Homo sapiens OX=9606 GN=SUMO3 PE=1 SV=2,0.001,11.87,45,2,39,2,103,11.6,5.49,20962,0,2,1,metabolic process;response to stimulus,chromosome;cytoplasm;nucleus,protein binding,"Pf00240, Pf11976",6612,ENSG00000184900.15,SUMO3,21,RNA transport,Exercise-induced Circadian Regulation,"SUMOylation of chromatin organization proteins; Formation of Incision Complex in GG-NER; SUMOylation of transcription factors; SUMOylation of DNA replication proteins; SUMO is conjugated to E1 (UBA2:SAE1); SUMOylation of DNA damage response and repair proteins; SUMO is proteolytically processed; SUMO is transferred from E1 to E2 (UBE2I, UBC9)",18,High,1
Q9Y3A3,MOB-like protein phocein OS=Homo sapiens OX=9606 GN=MOB4 PE=1 SV=1,0.001,11.859,11,2,22,2,225,26,5.78,9421,,2,,transport,cytoplasm;cytosol;Golgi;membrane,metal ion binding;protein binding,Pf03637,25843,ENSG00000115540.14,MOB4,2,,,,0,High,1
Q08AD1,Calmodulin-regulated spectrin-associated protein 2 OS=Homo sapiens OX=9606 GN=CAMSAP2 PE=1 SV=3,0.001,11.857,3,3,8,3,1489,168,6.8,3163,,3,,cell organization and biogenesis;regulation of biological process,cytoplasm;cytoskeleton;cytosol;Golgi,protein binding,"Pf00307, Pf08683, Pf11971",23271,ENSG00000118200.14,CAMSAP2,1,,,,0,High,1
A2A2Y4,FERM domain-containing protein 3 OS=Homo sapiens OX=9606 GN=FRMD3 PE=2 SV=1,0.001,11.836,5,2,12,2,597,68.7,6.39,5186,0,2,1,cell organization and biogenesis,cytoskeleton;membrane,protein binding;structural molecule activity,"Pf00373, Pf08736, Pf09379, Pf09380",257019,ENSG00000172159.15,FRMD3,9,,,,0,High,1
Q9UIV1,CCR4-NOT transcription complex subunit 7 OS=Homo sapiens OX=9606 GN=CNOT7 PE=1 SV=3,0.001,11.831,8,2,7,2,285,32.7,4.84,3792,,2,,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,catalytic activity;metal ion binding;protein binding;RNA binding;signal transducer activity,Pf04857,29883,ENSG00000198791.11,CNOT7,8,RNA degradation,,TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Deadenylation of mRNA,10,High,1
Q8TCZ2,CD99 antigen-like protein 2 OS=Homo sapiens OX=9606 GN=CD99L2 PE=1 SV=1,0.001,11.829,10,2,11,2,262,28,5.14,3651,,2,,,membrane,protein binding,"Pf12301, Pf13840",83692,ENSG00000102181.20,CD99L2,X,,,Cell surface interactions at the vascular wall,2,High,1
Q8TF64,PDZ domain-containing protein GIPC3 OS=Homo sapiens OX=9606 GN=GIPC3 PE=1 SV=1,0.001,11.827,9,2,8,1,312,34,5.63,4255,,2,,,,protein binding,Pf00595,126326,ENSG00000179855.5,GIPC3,19,,,,0,High,1
Q96LD4,E3 ubiquitin-protein ligase TRIM47 OS=Homo sapiens OX=9606 GN=TRIM47 PE=1 SV=2,0.001,11.822,3,2,9,2,638,69.5,6.44,3962,,2,,,cytoplasm;cytosol;nucleus,metal ion binding;protein binding,"Pf00097, Pf00622, Pf00643, Pf13445, Pf13639, Pf13765, Pf13920, Pf13923, Pf14634, Pf15227",91107,ENSG00000132481.6,TRIM47,17,,,,0,High,1
Q96AE7,Tetratricopeptide repeat protein 17 OS=Homo sapiens OX=9606 GN=TTC17 PE=1 SV=1,0.001,11.815,3,2,9,2,1141,129.5,6.58,3871,,2,,cell organization and biogenesis,cytoplasm;cytoskeleton;cytosol;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00515, Pf02841, Pf13414, Pf13424, Pf13432",55761,ENSG00000052841.14,TTC17,11,,,,0,High,1
Q9NVV0,Trimeric intracellular cation channel type B OS=Homo sapiens OX=9606 GN=TMEM38B PE=1 SV=1,0.001,11.81,8,2,5,2,291,32.5,9.06,2293,,2,,transport,endoplasmic reticulum;membrane;nucleus,transporter activity,Pf05197,55151,ENSG00000095209.11,TMEM38B,9,,,,0,High,1
Q9Y3D8,Adenylate kinase isoenzyme 6 OS=Homo sapiens OX=9606 GN=AK6 PE=1 SV=1,0.001,11.796,13,2,13,2,172,20,4.58,4657,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding,"Pf00004, Pf01202, Pf03266, Pf07726, Pf07728, Pf08433, Pf13173, Pf13191, Pf13207, Pf13238, Pf13521",102157402; 6880,ENSG00000085231.13; ENSG00000279247.3,AK6; TAF9,5; CHR_HSCHR5_2_CTG1_1,Metabolic pathways; Purine metabolism; Ribosome biogenesis in eukaryotes,Eukaryotic Transcription Initiation,Interconversion of nucleotide di- and triphosphates,7,High,1
O75420,GRB10-interacting GYF protein 1 OS=Homo sapiens OX=9606 GN=GIGYF1 PE=1 SV=2,0.001,11.77,3,2,8,2,1035,114.5,5.39,3728,,2,,regulation of biological process;response to stimulus,,protein binding,Pf02213,64599,ENSG00000146830.9,GIGYF1,7,,,,0,High,1
Q07817,Bcl-2-like protein 1 OS=Homo sapiens OX=9606 GN=BCL2L1 PE=1 SV=1,0.001,11.769,8,2,19,2,233,26,4.93,10040,,2,,cell death;cell organization and biogenesis;cell proliferation;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;membrane;mitochondrion;nucleus;organelle lumen,protein binding,"Pf00452, Pf02180",598,ENSG00000171552.12,BCL2L1,20,Toxoplasmosis; NF-kappa B signaling pathway; PI3K-Akt signaling pathway; Chronic myeloid leukemia; Small cell lung cancer; Apoptosis; EGFR tyrosine kinase inhibitor resistance; Pathways in cancer; Ras signaling pathway; NOD-like receptor signaling pathway; Transcriptional misregulation in cancer; Platinum drug resistance; Amyotrophic lateral sclerosis (ALS); Jak-STAT signaling pathway; HTLV-I infection; Apoptosis - multiple species; Pancreatic cancer,Leptin signaling pathway; IL-7 Signaling Pathway; TNF alpha Signaling Pathway; Amyotrophic lateral sclerosis (ALS); Apoptosis; IL-3 Signaling Pathway; Photodynamic therapy-induced HIF-1 survival signaling; IL-6 signaling pathway; Hepatitis C and Hepatocellular Carcinoma; Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex; LncRNA-mediated mechanisms of therapeutic resistance; Regulation of Apoptosis by Parathyroid Hormone-related Protein; VEGFA-VEGFR2 Signaling Pathway,The NLRP1 inflammasome; Interleukin-4 and 13 signaling; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members,42,High,1
P46527,Cyclin-dependent kinase inhibitor 1B OS=Homo sapiens OX=9606 GN=CDKN1B PE=1 SV=1,0.001,11.769,18,3,9,3,198,22.1,7.02,3191,,3,,cell death;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;nucleus,catalytic activity;enzyme regulator activity;protein binding;signal transducer activity,Pf02234,1027,ENSG00000111276.10,CDKN1B,12,Epstein-Barr virus infection; FoxO signaling pathway; Cell cycle; Viral carcinogenesis; Transcriptional misregulation in cancer; Pathways in cancer; Chronic myeloid leukemia; Endocrine resistance; HIF-1 signaling pathway; Measles; Prostate cancer; PI3K-Akt signaling pathway; Small cell lung cancer; AGE-RAGE signaling pathway in diabetic complications; ErbB signaling pathway; MicroRNAs in cancer; Hepatitis B,miRNA Regulation of DNA Damage Response; miRNAs involved in DNA damage response; Cell Cycle; Integrated Cancer pathway; Human Thyroid Stimulating Hormone (TSH) signaling pathway; IL-7 Signaling Pathway; Signaling Pathways in Glioblastoma; Oncostatin M Signaling Pathway; Spinal Cord Injury; Retinoblastoma (RB) in Cancer; Primary Focal Segmental Glomerulosclerosis FSGS; Aryl Hydrocarbon Receptor; Apoptosis-related network due to altered Notch3 in ovarian cancer; Aryl Hydrocarbon Receptor Pathway; Ovarian Infertility Genes; Imatinib and Chronic Myeloid Leukemia; Association Between Physico-Chemical Features and Toxicity Associated Pathways; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; miR-222 in Exercise-Induced Cardiac Growth; Oxidative Damage; G1 to S cell cycle control; Senescence and Autophagy in Cancer; ErbB Signaling Pathway; DNA Damage Response; DNA Damage Response (only ATM dependent),p53-Dependent G1 DNA Damage Response; AKT phosphorylates targets in the cytosol; Regulation of DNA replication; Cyclin D associated events in G1; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; RHO GTPases activate CIT; SCF(Skp2)-mediated degradation of p27/p21; Constitutive Signaling by AKT1 E17K in Cancer; Orc1 removal from chromatin; PTK6 Regulates Cell Cycle; DNA Damage/Telomere Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Removal of licensing factors from origins,88,High,1
O43395,U4/U6 small nuclear ribonucleoprotein Prp3 OS=Homo sapiens OX=9606 GN=PRPF3 PE=1 SV=2,0.001,11.714,7,3,5,3,683,77.5,9.5,1748,,3,,cell organization and biogenesis;metabolic process,cytosol;nucleus;spliceosomal complex,protein binding;RNA binding,"Pf01480, Pf06544, Pf08572",9129,ENSG00000117360.12,PRPF3,1,Spliceosome,mRNA Processing,mRNA Splicing - Major Pathway,6,High,1
Q9NX00,Transmembrane protein 160 OS=Homo sapiens OX=9606 GN=TMEM160 PE=1 SV=1,0.001,11.681,16,3,15,3,188,19.6,8.03,5360,,3,,,membrane;mitochondrion,,,54958,ENSG00000130748.6,TMEM160,19,,,,0,High,1
Q8TAG9,Exocyst complex component 6 OS=Homo sapiens OX=9606 GN=EXOC6 PE=1 SV=3,0.001,11.662,3,3,64,1,804,93.7,6.2,27962,,3,,transport,cytoplasm;cytosol;membrane,protein binding,Pf04091,54536,ENSG00000138190.16,EXOC6,10,,Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway,Translocation of GLUT4 to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium,11,High,1
P43246,DNA mismatch repair protein Msh2 OS=Homo sapiens OX=9606 GN=MSH2 PE=1 SV=1,0.001,11.661,3,3,11,3,934,104.7,5.77,3964,,3,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,membrane;nucleus,catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding,"Pf00488, Pf01624, Pf05188, Pf05190, Pf05192",4436,ENSG00000095002.13,MSH2,2,Colorectal cancer; Mismatch repair; Platinum drug resistance; Pathways in cancer,Rac1/Pak1/p38/MMP-2 pathway; Mismatch repair,Defective Mismatch Repair Associated With MSH3; Defective Mismatch Repair Associated With MSH2; Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); TP53 Regulates Transcription of DNA Repair Genes; Defective Mismatch Repair Associated With MSH6,20,High,1
Q6UWU4,Bombesin receptor-activated protein C6orf89 OS=Homo sapiens OX=9606 GN=C6orf89 PE=1 SV=1,0.001,11.657,6,2,15,2,347,39.8,6.83,7292,,2,,cell proliferation;regulation of biological process;response to stimulus,cytoplasm;Golgi;membrane;nucleus,protein binding,,221477,ENSG00000198663.16,C6orf89,6,,,,0,High,1
Q5T5Y3,Calmodulin-regulated spectrin-associated protein 1 OS=Homo sapiens OX=9606 GN=CAMSAP1 PE=1 SV=2,0.001,11.656,2,3,26,3,1602,177.9,6.73,9052,,3,,cell organization and biogenesis;regulation of biological process,cytoplasm;cytoskeleton,protein binding,"Pf00307, Pf08683, Pf11971",157922,ENSG00000130559.18,CAMSAP1,9,,,,0,High,1
Q8IWR0,Zinc finger CCCH domain-containing protein 7A OS=Homo sapiens OX=9606 GN=ZC3H7A PE=1 SV=1,0.001,11.637,5,2,8,2,971,110.5,7.3,3033,,2,,metabolic process;regulation of biological process;response to stimulus,nucleus,metal ion binding;protein binding;RNA binding,"Pf00642, Pf12171, Pf13414",29066,ENSG00000122299.11,ZC3H7A,16,,,,0,High,1
P62072,Mitochondrial import inner membrane translocase subunit Tim10 OS=Homo sapiens OX=9606 GN=TIMM10 PE=1 SV=1,0.001,11.637,22,2,11,2,90,10.3,6.29,5176,,2,,cell organization and biogenesis;transport,membrane;mitochondrion,metal ion binding;protein binding;transporter activity,Pf02953,26519,ENSG00000134809.8,TIMM10,11,,,Mitochondrial protein import; Metabolism of proteins,2,High,1
P49619,Diacylglycerol kinase gamma OS=Homo sapiens OX=9606 GN=DGKG PE=2 SV=3,0.001,11.621,5,3,8,3,791,89.1,6.8,2600,,3,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;membrane,catalytic activity;metal ion binding;nucleotide binding,"Pf00130, Pf00609, Pf00781, Pf13499, Pf14513",1608,ENSG00000058866.14,DGKG,3,Glycerolipid metabolism; Glycerophospholipid metabolism; Phosphatidylinositol signaling system; Phospholipase D signaling pathway; Metabolic pathways; Choline metabolism in cancer,,Effects of PIP2 hydrolysis; Gastrin-CREB signalling pathway via PKC and MAPK,14,High,1
P52630,Signal transducer and activator of transcription 2 OS=Homo sapiens OX=9606 GN=STAT2 PE=1 SV=1,0.001,11.621,5,4,6,4,851,97.9,5.49,1931,,4,,defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,DNA binding;protein binding;signal transducer activity,"Pf00017, Pf01017, Pf02864, Pf02865, Pf12188",6773,ENSG00000170581.13,STAT2,12,Osteoclast differentiation; Hepatitis C; Jak-STAT signaling pathway; NOD-like receptor signaling pathway; Influenza A; Herpes simplex infection; Hepatitis B; Chemokine signaling pathway; Measles,Type III interferon signaling; Adipogenesis; Chemokine signaling pathway; Interferon type I signaling pathways; Type II interferon signaling (IFNG),Regulation of IFNA signaling,19,High,1
Q9H2C0,Gigaxonin OS=Homo sapiens OX=9606 GN=GAN PE=1 SV=1,0.001,11.619,6,3,5,3,597,67.6,5.85,2308,,3,,cell organization and biogenesis;metabolic process,cytoplasm;cytoskeleton;cytosol,catalytic activity;protein binding,"Pf00651, Pf01344, Pf07707, Pf13415, Pf13418, Pf13964",8139,ENSG00000261609.5,GAN,16,,,Antigen processing: Ubiquitination & Proteasome degradation; Neddylation,7,High,1
Q9BSR8,Protein YIPF4 OS=Homo sapiens OX=9606 GN=YIPF4 PE=1 SV=1,0.001,11.61,13,3,24,3,244,27.1,4.65,9757,,3,,,endoplasmic reticulum;Golgi;membrane,protein binding,,84272,ENSG00000119820.10,YIPF4,2,,,,0,High,1
P11215,Integrin alpha-M OS=Homo sapiens OX=9606 GN=ITGAM PE=1 SV=2,0.001,11.606,2,2,6,2,1152,127.1,7.23,2495,0,2,1,cell differentiation;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport,cell surface;membrane,metal ion binding;protein binding,"Pf00092, Pf00357, Pf01839, Pf08441, Pf13519",3684,ENSG00000169896.16,ITGAM,16,Staphylococcus aureus infection; Complement and coagulation cascades; Rap1 signaling pathway; Regulation of actin cytoskeleton; Pertussis; Hematopoietic cell lineage; Legionellosis; Cell adhesion molecules (CAMs); Leukocyte transendothelial migration; Leishmaniasis; Transcriptional misregulation in cancer; Amoebiasis; Phagosome; Tuberculosis,Integrin-mediated Cell Adhesion; Focal Adhesion; Microglia Pathogen Phagocytosis Pathway; TYROBP Causal Network,Integrin cell surface interactions; Interleukin-4 and 13 signaling; Neutrophil degranulation; Toll Like Receptor 4 (TLR4) Cascade; Cell surface interactions at the vascular wall,30,High,1
Q71RC9,Small integral membrane protein 5 OS=Homo sapiens OX=9606 GN=SMIM5 PE=1 SV=2,0.001,11.59,13,1,8,1,77,8.5,7.96,4539,,1,,,membrane,,,643008,ENSG00000204323.5,SMIM5,17,,,,0,High,1
Q9H1C3,Glycosyltransferase 8 domain-containing protein 2 OS=Homo sapiens OX=9606 GN=GLT8D2 PE=2 SV=1,0.001,11.583,7,2,8,2,349,40,7.06,2305,,2,,metabolic process,Golgi;membrane,catalytic activity,Pf01501,83468,ENSG00000120820.12,GLT8D2,12,,,,0,High,1
Q9BT40,Inositol polyphosphate 5-phosphatase K OS=Homo sapiens OX=9606 GN=INPP5K PE=1 SV=3,0.001,11.563,6,2,7,2,448,51.1,6.54,3868,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus,catalytic activity;protein binding;receptor activity;signal transducer activity,"Pf03372, Pf07888",51763,ENSG00000132376.19,INPP5K,17,Phosphatidylinositol signaling system; Inositol phosphate metabolism; Insulin signaling pathway; Metabolic pathways,Notch Signaling Pathway,Synthesis of PIPs at the plasma membrane,10,High,1
P36639,"7,8-dihydro-8-oxoguanine triphosphatase OS=Homo sapiens OX=9606 GN=NUDT1 PE=1 SV=3",0.001,11.56,19,3,8,3,197,22.5,5.27,2723,,3,,cell communication;metabolic process;response to stimulus,cytoplasm;cytosol;membrane;mitochondrion;nucleus;organelle lumen,catalytic activity;metal ion binding;protein binding;RNA binding,Pf00293,4521,,NUDT1,7,,,Phosphate bond hydrolysis by NUDT proteins,5,High,1
Q9HAC7,Succinate--hydroxymethylglutarate CoA-transferase OS=Homo sapiens OX=9606 GN=SUGCT PE=1 SV=2,0.001,11.548,9,3,11,3,445,48.4,8.35,3656,,3,,metabolic process,mitochondrion,catalytic activity,Pf02515,79783,ENSG00000175600.15,C7orf10; SUGCT,7,,,,0,High,1
Q5T6J7,Probable gluconokinase OS=Homo sapiens OX=9606 GN=IDNK PE=1 SV=1,0.001,11.544,16,2,7,2,187,20.6,6.21,2875,,2,,metabolic process,,catalytic activity;nucleotide binding,"Pf01202, Pf13189, Pf13207, Pf13238, Pf13671",414328,ENSG00000148057.15,IDNK,9,Carbon metabolism; Metabolic pathways; Pentose phosphate pathway,,,3,High,1
Q9H9C1,Spermatogenesis-defective protein 39 homolog OS=Homo sapiens OX=9606 GN=VIPAS39 PE=1 SV=1,0.001,11.541,8,3,6,3,493,57,7.4,2301,,3,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;endosome;Golgi,protein binding,Pf09787,63894,ENSG00000151445.15,VIPAS39,14,,,,0,High,1
A0A0C4DH33,Immunoglobulin heavy variable 1-24 OS=Homo sapiens OX=9606 GN=IGHV1-24 PE=3 SV=1,0.001,11.534,23,2,13,1,117,12.8,5.16,3424,,2,,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,protein binding,Pf07686,28467,ENSG00000211950.2; ENSG00000282284.1,IGHV1-24,14; CHR_HSCHR14_3_CTG1,,,,0,High,1
Q9BWJ5,Splicing factor 3B subunit 5 OS=Homo sapiens OX=9606 GN=SF3B5 PE=1 SV=1,0.001,11.533,10,1,19,1,86,10.1,6.35,8048,,1,,metabolic process,nucleus;spliceosomal complex,RNA binding,Pf07189,83443,ENSG00000169976.6,SF3B5,6,Spliceosome,mRNA Processing,mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway,7,High,1
P57087,Junctional adhesion molecule B OS=Homo sapiens OX=9606 GN=JAM2 PE=1 SV=1,0.001,11.513,11,3,11,3,298,33.2,9.09,3809,,3,,cell organization and biogenesis;cellular component movement;regulation of biological process,membrane,protein binding,"Pf00047, Pf07679, Pf13895, Pf13927",58494,ENSG00000154721.14,JAM2,21,Leukocyte transendothelial migration; Tight junction; Epithelial cell signaling in Helicobacter pylori infection; Cell adhesion molecules (CAMs),,Integrin cell surface interactions; Cell surface interactions at the vascular wall,8,High,1
Q6EMK4,Vasorin OS=Homo sapiens OX=9606 GN=VASN PE=1 SV=1,0.001,11.462,6,3,15,3,673,71.7,7.39,6858,,3,,regulation of biological process;response to stimulus,cell surface;extracellular;membrane;mitochondrion,protein binding,"Pf00008, Pf00041, Pf12799, Pf13855",114990,ENSG00000168140.4; ENSG00000274334.1,VASN,16; CHR_HSCHR16_3_CTG1,,,,0,High,1
Q8N3R9,MAGUK p55 subfamily member 5 OS=Homo sapiens OX=9606 GN=MPP5 PE=1 SV=3,0.001,11.455,8,3,6,3,675,77.2,6.14,2325,,3,,cell organization and biogenesis,cytoplasm;membrane,protein binding,"Pf00018, Pf00595, Pf00625, Pf02828, Pf07653, Pf09060, Pf13180, Pf14604",64398,ENSG00000072415.8,MPP5,14,Tight junction; Hippo signaling pathway,,Tight junction interactions,6,High,1
O75376,Nuclear receptor corepressor 1 OS=Homo sapiens OX=9606 GN=NCOR1 PE=1 SV=2,0.001,11.45,3,4,40,4,2440,270,7.11,14585,,4,,cell organization and biogenesis;metabolic process;regulation of biological process,cytosol;membrane;nucleus,DNA binding;protein binding,"Pf00249, Pf13921",9611,ENSG00000141027.20,NCOR1,17,Transcriptional misregulation in cancer; Thyroid hormone signaling pathway; Endocrine resistance,Androgen receptor signaling pathway; Adipogenesis; Ovarian Infertility Genes; Mecp2 and Associated Rett Syndrome; Pathways Affected in Adenoid Cystic Carcinoma; Notch Signaling Pathway,"NOTCH1 Intracellular Domain Regulates Transcription; Transcriptional regulation of white adipocyte differentiation; RORA activates gene expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; PPARA activates gene expression; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Constitutive Signaling by NOTCH1 PEST Domain Mutants; NR1D1 (REV-ERBA) represses gene expression; HDACs deacetylate histones; Transcriptional activation of mitochondrial biogenesis; Nuclear signaling by ERBB4; BMAL1:CLOCK,NPAS2 activates circadian gene expression",48,High,1
O43493,Trans-Golgi network integral membrane protein 2 OS=Homo sapiens OX=9606 GN=TGOLN2 PE=1 SV=4,0.001,11.448,8,3,17,3,437,45.9,5.63,6213,,3,,,,,,,,,,,,,0,High,1
Q13303,Voltage-gated potassium channel subunit beta-2 OS=Homo sapiens OX=9606 GN=KCNAB2 PE=1 SV=2,0.001,11.418,11,3,7,3,367,41,9,1749,0,3,1,cell differentiation;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;membrane,catalytic activity;transporter activity,Pf00248,8514,ENSG00000069424.14,KCNAB2,1,,Metapathway biotransformation,Voltage gated Potassium channels; Neutrophil degranulation,7,High,1
Q7Z6M4,"Transcription termination factor 4, mitochondrial OS=Homo sapiens OX=9606 GN=MTERF4 PE=1 SV=3",0.001,11.409,10,2,3,2,381,43.9,4.82,1345,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytosol;mitochondrion;organelle lumen,DNA binding;protein binding;RNA binding,,130916,ENSG00000122085.16,MTERFD2; MTERF4,2,,,rRNA modification in the mitochondrion,4,High,1
Q96KC8,DnaJ homolog subfamily C member 1 OS=Homo sapiens OX=9606 GN=DNAJC1 PE=1 SV=1,0.001,11.403,6,3,8,3,554,63.8,8.63,2882,,3,,metabolic process;regulation of biological process,endoplasmic reticulum;membrane;nucleus,DNA binding;enzyme regulator activity;protein binding,"Pf00226, Pf00249",64215,ENSG00000136770.10,DNAJC1,10,Protein processing in endoplasmic reticulum,,,1,High,1
Q9NVH2,Integrator complex subunit 7 OS=Homo sapiens OX=9606 GN=INTS7 PE=1 SV=1,0.001,11.403,6,3,4,3,962,106.8,8.02,1310,,3,,metabolic process;response to stimulus;transport,chromosome;cytoplasm;cytosol;nucleus,protein binding;transporter activity,,25896,ENSG00000143493.12,INTS7,1,,,RNA polymerase II transcribes snRNA genes,3,High,1
Q9NRX5,Serine incorporator 1 OS=Homo sapiens OX=9606 GN=SERINC1 PE=1 SV=1,0.001,11.397,7,2,7,2,453,50.5,5.85,3297,,2,,metabolic process;transport,endoplasmic reticulum;membrane,protein binding;transporter activity,Pf03348,57515,ENSG00000111897.6,SERINC1,6,,Sphingolipid Metabolism,Serine biosynthesis,5,High,1
A0A0C4DH24,Immunoglobulin kappa variable 6-21 OS=Homo sapiens OX=9606 GN=IGKV6-21 PE=3 SV=1,0.001,11.394,25,2,5,2,114,12.4,7.28,2750,,2,,response to stimulus,extracellular;membrane,,"Pf00047, Pf07686",28906,ENSG00000282210.1; ENSG00000211611.2,IGKV6-21,CHR_HG2290_PATCH; 2,,,,0,High,1
Q9UFC0,Leucine-rich repeat and WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=LRWD1 PE=1 SV=2,0.001,11.383,4,2,6,2,647,70.8,7.21,3681,,2,,cell organization and biogenesis;metabolic process,chromosome;cytoplasm;cytoskeleton;cytosol;nucleus,DNA binding;nucleotide binding;protein binding,"Pf00400, Pf12799, Pf13855",222229,ENSG00000161036.12,LRWD1,7,,,,0,High,1
O75525,"KH domain-containing, RNA-binding, signal transduction-associated protein 3 OS=Homo sapiens OX=9606 GN=KHDRBS3 PE=1 SV=1",0.001,11.364,7,3,33,2,346,38.8,7.61,13632,,3,,cell organization and biogenesis;metabolic process;regulation of biological process,nucleus,protein binding;RNA binding,Pf00013,10656,ENSG00000131773.13,KHDRBS3,8,,,PTK6 Regulates Proteins Involved in RNA Processing,4,High,1
P63165,Small ubiquitin-related modifier 1 OS=Homo sapiens OX=9606 GN=SUMO1 PE=1 SV=1,0.001,11.357,28,3,34,3,101,11.6,5.52,12706,,3,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;membrane;nucleus,catalytic activity;protein binding;RNA binding,"Pf00240, Pf11976",7341,ENSG00000116030.16,SUMO1,2,RNA transport,Androgen receptor signaling pathway; TP53 Network; TGF-beta Signaling Pathway; Exercise-induced Circadian Regulation,"G2/M DNA damage checkpoint; SUMOylation of DNA replication proteins; Nonhomologous End-Joining (NHEJ); SUMOylation of RNA binding proteins; Negative regulation of activity of TFAP2 (AP-2) family transcription factors; SUMOylation of chromatin organization proteins; Formation of Incision Complex in GG-NER; Regulation of IFNG signaling; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; SUMOylation of transcription factors; SUMO is conjugated to E1 (UBA2:SAE1); SUMOylation of DNA damage response and repair proteins; SUMO is proteolytically processed; SUMO is transferred from E1 to E2 (UBE2I, UBC9)",43,High,1
O75175,CCR4-NOT transcription complex subunit 3 OS=Homo sapiens OX=9606 GN=CNOT3 PE=1 SV=1,0.001,11.35,6,4,9,4,753,81.8,6.2,4152,,4,,cell differentiation;development;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,protein binding,"Pf04065, Pf04153",4849,ENSG00000274176.4; ENSG00000274616.4; ENSG00000277600.4; ENSG00000273943.4; ENSG00000088038.17; ENSG00000276082.4; ENSG00000275979.4; ENSG00000277114.4; ENSG00000274941.4; ENSG00000277615.4,CNOT3,19; CHR_HSCHR19LRC_COX2_CTG3_1; CHR_HSCHR19LRC_PGF1_CTG3_1; CHR_HSCHR19_4_CTG3_1; CHR_HSCHR19LRC_LRC_T_CTG3_1; CHR_HSCHR19LRC_LRC_J_CTG3_1; CHR_HSCHR19LRC_LRC_S_CTG3_1; CHR_HSCHR19LRC_COX1_CTG3_1; CHR_HSCHR19LRC_LRC_I_CTG3_1; CHR_HSCHR19LRC_PGF2_CTG3_1,RNA degradation,,TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Deadenylation of mRNA,10,High,1
O00411,"DNA-directed RNA polymerase, mitochondrial OS=Homo sapiens OX=9606 GN=POLRMT PE=1 SV=2",0.001,11.338,3,3,7,3,1230,138.5,8.98,2593,,3,,cell organization and biogenesis;metabolic process,mitochondrion;organelle lumen,catalytic activity;DNA binding;protein binding;RNA binding,"Pf00940, Pf14700",5442,ENSG00000099821.13,POLRMT,19,,Mitochondrial Gene Expression,Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis,7,High,1
Q96K21,Abscission/NoCut checkpoint regulator OS=Homo sapiens OX=9606 GN=ZFYVE19 PE=1 SV=3,0.001,11.337,6,2,9,2,471,51.5,5.73,2981,,2,,cell division;regulation of biological process,cytoplasm;cytoskeleton,metal ion binding;protein binding,Pf01363,84936,ENSG00000166140.17,ZFYVE19,15,,,,0,High,1
A8CG34,Nuclear envelope pore membrane protein POM 121C OS=Homo sapiens OX=9606 GN=POM121C PE=1 SV=3,0.001,11.33,3,3,11,2,1229,125,10.37,4190,,3,,,,,,,,,,,,,0,High,1
Q9H1K1,"Iron-sulfur cluster assembly enzyme ISCU, mitochondrial OS=Homo sapiens OX=9606 GN=ISCU PE=1 SV=2",0.001,11.31,10,2,33,2,167,18,9.48,16783,,2,,cell organization and biogenesis;cellular homeostasis;metabolic process,cytoplasm;cytosol;mitochondrion;nucleus;organelle lumen,catalytic activity;metal ion binding;protein binding;structural molecule activity,Pf01592,23479,ENSG00000136003.15,ISCU,12,,,Mitochondrial iron-sulfur cluster biogenesis,2,High,1
O00534,von Willebrand factor A domain-containing protein 5A OS=Homo sapiens OX=9606 GN=VWA5A PE=2 SV=2,0.001,11.307,4,3,6,3,786,86.4,6.58,2168,,3,,,,,"Pf00092, Pf08487, Pf13519, Pf13757, Pf13768",4013,ENSG00000110002.15,VWA5A,11,,,,0,High,1
Q49B96,Cytochrome c oxidase assembly protein COX19 OS=Homo sapiens OX=9606 GN=COX19 PE=1 SV=1,0.001,11.303,21,2,23,2,90,10.4,8.72,12053,1.63,2,1,cell organization and biogenesis;metabolic process,cytoplasm;cytosol,,Pf06747,90639,ENSG00000240230.5,COX19,7,,,Mitochondrial protein import; Metabolism of proteins,2,High,1
Q969P0,Immunoglobulin superfamily member 8 OS=Homo sapiens OX=9606 GN=IGSF8 PE=1 SV=1,0.001,11.301,6,3,20,3,613,65,8,8169,,3,,cell proliferation;cellular component movement,membrane,protein binding,Pf07686,93185,ENSG00000162729.13,IGSF8,1,,,,0,High,1
Q96EK4,THAP domain-containing protein 11 OS=Homo sapiens OX=9606 GN=THAP11 PE=1 SV=2,0.001,11.284,5,2,12,2,314,34.4,8.98,4410,,2,,metabolic process;regulation of biological process,cytoplasm;nucleus,DNA binding;metal ion binding;protein binding,Pf05485,57215,ENSG00000168286.2,THAP11,16,,,,0,High,1
Q9H6T3,RNA polymerase II-associated protein 3 OS=Homo sapiens OX=9606 GN=RPAP3 PE=1 SV=2,0.001,11.27,5,3,19,3,665,75.7,6.84,6672,,3,,,,protein binding,"Pf00515, Pf07010, Pf07719, Pf13414, Pf13424, Pf13432, Pf13877",79657,ENSG00000005175.9,RPAP3,12,,,,0,High,1
Q7L9B9,Endonuclease/exonuclease/phosphatase family domain-containing protein 1 OS=Homo sapiens OX=9606 GN=EEPD1 PE=1 SV=2,0.001,11.246,9,4,9,4,569,62.4,8.41,2800,,4,,metabolic process;response to stimulus;transport,,DNA binding,"Pf00633, Pf03372, Pf03934, Pf12836, Pf14520, Pf14579",80820,ENSG00000122547.10,EEPD1,7,,,,0,High,1
Q9BQI9,Nuclear receptor-interacting protein 2 OS=Homo sapiens OX=9606 GN=NRIP2 PE=1 SV=3,0.001,11.245,8,2,13,2,281,31.3,8.4,5812,,2,,metabolic process;regulation of biological process,cytoplasm;nucleus,catalytic activity;protein binding,,83714,ENSG00000053702.14,NRIP2,12,,,,0,High,1
Q9Y530,ADP-ribose glycohydrolase OARD1 OS=Homo sapiens OX=9606 GN=OARD1 PE=1 SV=2,0.001,11.233,16,2,6,2,152,17,8.31,3117,,2,,metabolic process,,catalytic activity;protein binding,Pf01661,221443,ENSG00000124596.16,OARD1,6,,,,0,High,1
Q8TEQ8,GPI ethanolamine phosphate transferase 3 OS=Homo sapiens OX=9606 GN=PIGO PE=1 SV=3,0.001,11.228,3,3,8,3,1089,118.6,8.12,2834,,3,,metabolic process,endoplasmic reticulum;membrane,catalytic activity,Pf01663,84720,ENSG00000165282.13,PIGO,9,Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways,,Synthesis of glycosylphosphatidylinositol (GPI),6,High,1
Q9UPQ9,Trinucleotide repeat-containing gene 6B protein OS=Homo sapiens OX=9606 GN=TNRC6B PE=1 SV=4,0.001,11.225,1,2,2,2,1833,193.9,6.76,964,,2,,regulation of biological process;response to stimulus,cytoplasm;cytosol,protein binding;RNA binding,"Pf10427, Pf13893",23112,ENSG00000100354.20,TNRC6B,22,,,Post-transcriptional silencing by small RNAs; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Ca2+ pathway; Competing endogenous RNAs (ceRNAs) regulate PTEN translation; Regulation of RUNX1 Expression and Activity; MAPK6/MAPK4 signaling; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Pre-NOTCH Transcription and Translation; Oxidative Stress Induced Senescence,29,High,1
Q9BRT3,Migration and invasion enhancer 1 OS=Homo sapiens OX=9606 GN=MIEN1 PE=1 SV=1,0.001,11.216,18,2,14,2,115,12.4,4.37,6772,,2,,cell death;regulation of biological process,cytoplasm;cytosol;membrane,protein binding,Pf10262,84299,ENSG00000141741.11,MIEN1,17,,,,0,High,1
O75394,"39S ribosomal protein L33, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL33 PE=1 SV=1",0.001,11.214,17,1,20,1,65,7.6,10.8,10095,,1,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,structural molecule activity,"Pf00471, Pf06204",9553,ENSG00000243147.7,MRPL33,2,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
P23743,Diacylglycerol kinase alpha OS=Homo sapiens OX=9606 GN=DGKA PE=1 SV=3,0.001,11.211,5,3,8,2,735,82.6,6.73,3046,,3,,metabolic process;regulation of biological process;response to stimulus,cytosol;membrane,catalytic activity;metal ion binding;nucleotide binding,"Pf00130, Pf00609, Pf00781, Pf13499, Pf14513",1606,ENSG00000065357.19,DGKA,12,Glycerophospholipid metabolism; Glycerolipid metabolism; Choline metabolism in cancer; Phospholipase D signaling pathway; Metabolic pathways; Phosphatidylinositol signaling system,,Effects of PIP2 hydrolysis; Gastrin-CREB signalling pathway via PKC and MAPK,14,High,1
Q96EY5,Multivesicular body subunit 12A OS=Homo sapiens OX=9606 GN=MVB12A PE=1 SV=1,0.001,11.21,15,2,5,2,273,28.8,8.91,2212,,2,,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endosome;Golgi;membrane;nucleus,protein binding,Pf10240,93343,ENSG00000141971.12,FAM125A; MVB12A,19,Endocytosis,,Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); Membrane binding and targetting of GAG proteins,13,High,1
P61513,60S ribosomal protein L37a OS=Homo sapiens OX=9606 GN=RPL37A PE=1 SV=2,0.001,11.204,20,1,7,1,92,10.3,10.43,4473,,1,,cell organization and biogenesis;metabolic process;transport,cytosol;nucleus;ribosome,metal ion binding;protein binding;RNA binding;structural molecule activity,Pf01780,6168,ENSG00000197756.9,RPL37A,2,Ribosome,Cytoplasmic Ribosomal Proteins,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,34,High,1
Q99848,Probable rRNA-processing protein EBP2 OS=Homo sapiens OX=9606 GN=EBNA1BP2 PE=1 SV=2,0.001,11.196,7,2,5,2,306,34.8,10.1,2859,,2,,metabolic process,nucleus,protein binding;RNA binding,Pf05890,10969,ENSG00000117395.12,EBNA1BP2,1,,,Major pathway of rRNA processing in the nucleolus and cytosol,4,High,1
Q9Y3T9,Nucleolar complex protein 2 homolog OS=Homo sapiens OX=9606 GN=NOC2L PE=1 SV=4,0.001,11.16,3,2,14,2,749,84.9,5.62,4278,,2,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytosol;nucleus,protein binding;RNA binding,Pf03715,26155,ENSG00000188976.10,NOC2L,1,,,Regulation of TP53 Activity through Phosphorylation,6,High,1
Q9UNQ2,Probable dimethyladenosine transferase OS=Homo sapiens OX=9606 GN=DIMT1 PE=1 SV=1,0.001,11.153,12,3,4,3,313,35.2,9.99,1644,,3,,metabolic process;regulation of biological process,cytosol;nucleus;organelle lumen,catalytic activity;RNA binding,"Pf00398, Pf13659",27292,ENSG00000086189.9,DIMT1,5,,,rRNA modification in the nucleus and cytosol,4,High,1
Q5T1C6,Acyl-coenzyme A thioesterase THEM4 OS=Homo sapiens OX=9606 GN=THEM4 PE=1 SV=1,0.001,11.139,8,2,15,2,240,27.1,8.28,7938,,2,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;mitochondrion;organelle lumen,catalytic activity;protein binding,Pf03061,117145,ENSG00000159445.12,THEM4,1,PI3K-Akt signaling pathway,,Mitochondrial Fatty Acid Beta-Oxidation; CD28 dependent PI3K/Akt signaling; Activation of AKT2; VEGFR2 mediated vascular permeability; Negative regulation of the PI3K/AKT network,26,High,1
Q9UBI9,Headcase protein homolog OS=Homo sapiens OX=9606 GN=HECA PE=1 SV=1,0.001,11.138,4,2,9,2,543,58.8,8.54,4338,,2,,development;regulation of biological process,cytoplasm;membrane;nucleus,,Pf15353,51696,ENSG00000112406.4,HECA,6,,,,0,High,1
Q9H4I3,TraB domain-containing protein OS=Homo sapiens OX=9606 GN=TRABD PE=1 SV=1,0.001,11.125,11,3,4,3,376,42.3,8,1504,,3,,,,,Pf01963,80305,ENSG00000170638.9,TRABD,22,,,,0,High,1
Q86YP4,Transcriptional repressor p66-alpha OS=Homo sapiens OX=9606 GN=GATAD2A PE=1 SV=1,0.001,11.105,5,3,6,2,633,68,9.94,2937,,3,,metabolic process;regulation of biological process,nucleus,DNA binding;metal ion binding;protein binding,,54815,ENSG00000167491.17,GATAD2A,19,,,ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation,20,High,1
O14732,Inositol monophosphatase 2 OS=Homo sapiens OX=9606 GN=IMPA2 PE=1 SV=1,0.001,11.095,8,2,12,2,288,31.3,6.61,5181,,2,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,catalytic activity;metal ion binding;protein binding,Pf00459,3613,ENSG00000141401.11,IMPA2,18,Phosphatidylinositol signaling system; Metabolic pathways; Inositol phosphate metabolism,,"Synthesis of IP2, IP, and Ins in the cytosol",6,High,1
Q13610,Periodic tryptophan protein 1 homolog OS=Homo sapiens OX=9606 GN=PWP1 PE=1 SV=1,0.001,11.093,3,1,7,1,501,55.8,4.77,3441,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,Golgi;nucleus,protein binding,Pf00400,11137,ENSG00000136045.11,PWP1,12,,,,0,High,1
Q9NPB8,Glycerophosphocholine phosphodiesterase GPCPD1 OS=Homo sapiens OX=9606 GN=GPCPD1 PE=1 SV=2,0.001,11.086,6,3,8,3,672,76,5.53,3493,,3,,cellular homeostasis;metabolic process,cytoplasm;cytosol,catalytic activity,"Pf00686, Pf03009",56261,ENSG00000125772.12,GPCPD1,20,Glycerophospholipid metabolism; Choline metabolism in cancer,,Hydrolysis of LPC; Hydrolysis of LPE,8,High,1
P01824,Immunoglobulin heavy variable 4-39 OS=Homo sapiens OX=9606 GN=IGHV4-39 PE=1 SV=2,0.001,11.083,19,3,21,1,125,13.9,9.26,6443,,3,,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity;protein binding,,28394,ENSG00000211959.2; ENSG00000282579.1,IGHV4-39,14; CHR_HSCHR14_3_CTG1,,,FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis,26,High,1
Q8NC44,Reticulophagy regulator 2 OS=Homo sapiens OX=9606 GN=RETREG2 PE=1 SV=3,0.001,11.08,6,2,9,2,543,57.8,4.45,4425,,2,,,membrane,protein binding,,79137,ENSG00000144567.10,FAM134A; RETREG2,2,,,,0,High,1
P10915,Hyaluronan and proteoglycan link protein 1 OS=Homo sapiens OX=9606 GN=HAPLN1 PE=2 SV=2,0.001,11.073,7,3,20,3,354,40.1,7.42,8031,0,3,1,cell organization and biogenesis,extracellular,structural molecule activity,Pf00193,1404,ENSG00000145681.10,HAPLN1,5,,,ECM proteoglycans,2,High,1
P20933,N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase OS=Homo sapiens OX=9606 GN=AGA PE=1 SV=2,0.001,11.051,8,2,6,2,346,37.2,6.28,2591,,2,,metabolic process;transport,endoplasmic reticulum;extracellular;organelle lumen;vacuole,catalytic activity;protein binding,Pf01112,175,ENSG00000038002.8,AGA,4,Lysosome; Other glycan degradation,,Neutrophil degranulation,5,High,1
Q6DD87,Zinc finger protein 787 OS=Homo sapiens OX=9606 GN=ZNF787 PE=1 SV=4,0.001,11.044,7,2,7,2,382,40.4,7.96,3375,,2,,metabolic process;regulation of biological process,nucleus,DNA binding;metal ion binding,"Pf00096, Pf13465",126208,ENSG00000142409.5,ZNF787,19,,,,0,High,1
Q8WV60,"Pentatricopeptide repeat-containing protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=PTCD2 PE=1 SV=3",0.001,11.036,6,3,9,3,388,43.9,9.23,3714,,3,,cell organization and biogenesis;metabolic process;regulation of biological process,mitochondrion,protein binding;RNA binding,"Pf10037, Pf13041",79810,ENSG00000049883.14,PTCD2,5,,,,0,High,1
Q13061,Triadin OS=Homo sapiens OX=9606 GN=TRDN PE=1 SV=4,0.001,11.01,6,3,68,3,729,81.5,9.42,16790,17.79,1,3,cell organization and biogenesis;cellular homeostasis;regulation of biological process;transport,cytosol;endoplasmic reticulum;membrane;organelle lumen,protein binding,,10345,ENSG00000186439.12,TRDN,6,,,Ion homeostasis; Stimuli-sensing channels,6,High,1
Q9Y5Q0,Fatty acid desaturase 3 OS=Homo sapiens OX=9606 GN=FADS3 PE=1 SV=1,0.001,11.005,6,2,15,2,445,51.1,7.77,3978,,2,,metabolic process;transport,endoplasmic reticulum;membrane,catalytic activity,"Pf00173, Pf00487",3995,ENSG00000221968.8,FADS3,11,,,,0,High,1
P08493,Matrix Gla protein OS=Homo sapiens OX=9606 GN=MGP PE=1 SV=2,0.001,11.005,28,2,12,2,103,12.3,9.67,7134,,2,,cell differentiation;development;regulation of biological process,extracellular,metal ion binding;protein binding;structural molecule activity,Pf00594,4256,ENSG00000111341.9,MGP,12,,NOTCH1 regulation of human endothelial cell calcification; Endochondral Ossification,,2,High,1
Q8NE01,Metal transporter CNNM3 OS=Homo sapiens OX=9606 GN=CNNM3 PE=1 SV=1,0.001,10.985,6,4,6,3,707,76.1,6.09,2073,,4,,transport,membrane,protein binding,Pf00571,26505,ENSG00000168763.15,CNNM3,2,,,,0,High,1
Q8NFH4,Nucleoporin Nup37 OS=Homo sapiens OX=9606 GN=NUP37 PE=1 SV=1,0.001,10.965,10,2,6,2,326,36.7,5.92,2254,,2,,cell division;cell organization and biogenesis;metabolic process;regulation of biological process;transport,chromosome;cytosol;nucleus,protein binding,Pf00400,79023,ENSG00000075188.8,NUP37,12,RNA transport,,Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; Separation of Sister Chromatids; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Resolution of Sister Chromatid Cohesion; Transport of Ribonucleoproteins into the Host Nucleus; RHO GTPases Activate Formins; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins,77,High,1
O60934,Nibrin OS=Homo sapiens OX=9606 GN=NBN PE=1 SV=1,0.001,10.929,5,3,8,3,754,84.9,6.9,2474,,3,,cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus,chromosome;cytosol;nucleus,catalytic activity;DNA binding;protein binding,"Pf00498, Pf00533, Pf08599",4683,ENSG00000104320.13,NBN,8,Homologous recombination,miRNA Regulation of DNA Damage Response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM Signaling Network in Development and Disease; DNA Damage Response,G2/M DNA damage checkpoint; Presynaptic phase of homologous DNA pairing and strand exchange; Nonhomologous End-Joining (NHEJ); Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Meiotic recombination; Sensing of DNA Double Strand Breaks; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); HDR through MMEJ (alt-NHEJ); DNA Damage/Telomere Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; Resolution of D-loop Structures through Holliday Junction Intermediates,40,High,1
Q9H936,Mitochondrial glutamate carrier 1 OS=Homo sapiens OX=9606 GN=SLC25A22 PE=1 SV=1,0.001,10.924,7,3,55,3,323,34.4,9.29,20015,,3,,transport,membrane;mitochondrion,transporter activity,Pf00153,79751,ENSG00000177542.10,SLC25A22,11,,,Organic anion transporters,4,High,1
Q969M3,Protein YIPF5 OS=Homo sapiens OX=9606 GN=YIPF5 PE=1 SV=1,0.001,10.918,8,2,10,2,257,28,4.36,3649,,2,,regulation of biological process;transport,endoplasmic reticulum;Golgi;membrane,catalytic activity;protein binding,Pf01694,81555,ENSG00000145817.16,YIPF5,5,,,,0,High,1
Q96B23,Uncharacterized protein C18orf25 OS=Homo sapiens OX=9606 GN=C18orf25 PE=1 SV=3,0.001,10.918,11,3,8,3,404,43.4,4.88,3698,,3,,metabolic process,,catalytic activity;protein binding,Pf15303,147339,ENSG00000152242.10,C18orf25,18,,,,0,High,1
Q9Y2H0-1,Isoform 2 of Disks large-associated protein 4 OS=Homo sapiens OX=9606 GN=DLGAP4,0.001,10.904,2,2,8,2,989,107.5,7.3,4192,,2,,cell organization and biogenesis,membrane,protein binding,Pf03359,22839,ENSG00000080845.17,DLGAP4,20,,,,0,High,1
P63313,Thymosin beta-10 OS=Homo sapiens OX=9606 GN=TMSB10 PE=1 SV=2,0.001,10.896,32,1,11,1,44,5,5.36,7091,,1,,cell organization and biogenesis,cytoplasm;cytoskeleton,protein binding,,9168,ENSG00000034510.5,TMSB10,2,,,,0,High,1
Q9BTM9,Ubiquitin-related modifier 1 OS=Homo sapiens OX=9606 GN=URM1 PE=1 SV=1,0.001,10.893,20,2,23,2,101,11.4,4.67,7506,,2,,metabolic process,cytoplasm;cytosol,catalytic activity;protein binding,Pf09138,81605,ENSG00000167118.10,URM1,9,Sulfur relay system,,tRNA modification in the nucleus and cytosol,4,High,1
O75063,Glycosaminoglycan xylosylkinase OS=Homo sapiens OX=9606 GN=FAM20B PE=1 SV=1,0.001,10.881,5,1,3,1,409,46.4,6.87,2408,,1,,metabolic process,Golgi;membrane,catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding,Pf06702,9917,ENSG00000116199.11,FAM20B,1,,,,0,High,1
Q9GZU7,Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 OS=Homo sapiens OX=9606 GN=CTDSP1 PE=1 SV=1,0.001,10.879,13,3,5,2,261,29.2,6,1635,,3,,metabolic process;regulation of biological process,nucleus,catalytic activity;metal ion binding;protein binding,Pf03031,58190,ENSG00000144579.7,CTDSP1,2,,mir-124 predicted interactions with cell cycle and differentiation,,1,High,1
P56589,Peroxisomal biogenesis factor 3 OS=Homo sapiens OX=9606 GN=PEX3 PE=1 SV=1,0.001,10.86,16,3,22,3,373,42.1,8.15,2259,,3,,cell organization and biogenesis;transport,cytosol;endoplasmic reticulum;membrane,protein binding,Pf04882,8504,ENSG00000034693.14,PEX3,6,Peroxisome,,ABC transporters in lipid homeostasis,4,High,1
A0A0C4DH29,Immunoglobulin heavy variable 1-3 OS=Homo sapiens OX=9606 GN=IGHV1-3 PE=3 SV=1,0.001,10.851,29,3,4,1,117,13,9.55,1671,,3,,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,protein binding,,28473,ENSG00000211935.3; ENSG00000282213.1,IGHV1-3,14; CHR_HSCHR14_3_CTG1,,,,0,High,1
Q68DD2,Cytosolic phospholipase A2 zeta OS=Homo sapiens OX=9606 GN=PLA2G4F PE=2 SV=3,0.001,10.787,5,2,7,2,849,95,5.44,2560,4.93,1,1,metabolic process;response to stimulus;transport,cytoplasm;cytosol;membrane;vacuole,catalytic activity;metal ion binding;protein binding,"Pf00168, Pf01735",255189,ENSG00000168907.13,PLA2G4F,15,Arachidonic acid metabolism; Platelet activation; Phospholipase D signaling pathway; Ras signaling pathway; Serotonergic synapse; Long-term depression; MAPK signaling pathway; GnRH signaling pathway; Glutamatergic synapse; Fc epsilon RI signaling pathway; Linoleic acid metabolism; alpha-Linolenic acid metabolism; Ether lipid metabolism; Oxytocin signaling pathway; Inflammatory mediator regulation of TRP channels; VEGF signaling pathway; Glycerophospholipid metabolism; Metabolic pathways; Ovarian steroidogenesis; Choline metabolism in cancer; Fc gamma R-mediated phagocytosis; Vascular smooth muscle contraction,,Acyl chain remodelling of PI; Acyl chain remodelling of PG; Acyl chain remodelling of PS; Hydrolysis of LPC; Acyl chain remodelling of PE; Acyl chain remodelling of PC,32,High,1
P19474,E3 ubiquitin-protein ligase TRIM21 OS=Homo sapiens OX=9606 GN=TRIM21 PE=1 SV=1,0.001,10.781,7,2,5,2,475,54.1,6.38,2221,,2,,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus;vacuole,catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding,"Pf00097, Pf00622, Pf00643, Pf11789, Pf12128, Pf12678, Pf13445, Pf13639, Pf13765, Pf13920, Pf13923, Pf14570, Pf14634, Pf14835, Pf15227",6737,ENSG00000132109.9,TRIM21,11,Systemic lupus erythematosus,,STING mediated induction of host immune responses; Antigen processing: Ubiquitination & Proteasome degradation; Interferon gamma signaling; Regulation of innate immune responses to cytosolic DNA,12,High,1
Q9Y5S8,NADPH oxidase 1 OS=Homo sapiens OX=9606 GN=NOX1 PE=1 SV=2,0.001,10.776,7,2,6,1,564,64.8,8.5,2345,,2,,cell organization and biogenesis;cellular component movement;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;endosome;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding;transporter activity,"Pf00175, Pf00970, Pf01794, Pf08022, Pf08030",27035,ENSG00000007952.17,NOX1,X,Osteoclast differentiation; Phagosome; HIF-1 signaling pathway; NOD-like receptor signaling pathway; Leukocyte transendothelial migration; AGE-RAGE signaling pathway in diabetic complications,TNF alpha Signaling Pathway,RHO GTPases Activate NADPH Oxidases,11,High,1
Q8WUI4,Histone deacetylase 7 OS=Homo sapiens OX=9606 GN=HDAC7 PE=1 SV=2,0.001,10.774,5,2,2,2,952,102.9,7.58,923,,2,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;protein binding,Pf00850,51564,ENSG00000061273.17,HDAC7,12,Viral carcinogenesis; Alcoholism,MicroRNAs in cardiomyocyte hypertrophy; Cell Cycle; Neural Crest Differentiation; Cardiac Hypertrophic Response; Initiation of transcription and translation elongation at the HIV-1 LTR; VEGFA-VEGFR2 Signaling Pathway,NOTCH1 Intracellular Domain Regulates Transcription; Regulation of PTEN gene transcription; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; SUMOylation of DNA damage response and repair proteins,28,High,1
P53816,Phospholipase A and acyltransferase 3 OS=Homo sapiens OX=9606 GN=PLAAT3 PE=1 SV=2,0.001,10.769,12,2,13,2,162,17.9,7.99,6012,,2,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;endoplasmic reticulum;membrane,catalytic activity;protein binding,"Pf00877, Pf04970",11145,ENSG00000176485.11,PLA2G16,11,Metabolic pathways; Glycerophospholipid metabolism; Ether lipid metabolism; alpha-Linolenic acid metabolism; Linoleic acid metabolism; Regulation of lipolysis in adipocytes; Ras signaling pathway; Arachidonic acid metabolism,,Acyl chain remodelling of PI; Acyl chain remodelling of PS; Acyl chain remodelling of PE; Acyl chain remodelling of PC,16,High,1
Q86W50,RNA N6-adenosine-methyltransferase METTL16 OS=Homo sapiens OX=9606 GN=METTL16 PE=1 SV=2,0.001,10.767,4,2,7,2,562,63.6,7.85,3217,,2,,metabolic process;regulation of biological process,nucleus,catalytic activity;RNA binding,Pf05971,79066,ENSG00000127804.12,METTL16,17,,,,0,High,1
Q9NPA8,Transcription and mRNA export factor ENY2 OS=Homo sapiens OX=9606 GN=ENY2 PE=1 SV=1,0.001,10.766,26,2,16,2,101,11.5,9.33,8817,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,mitochondrion;nucleus,,Pf10163,56943,ENSG00000120533.12,ENY2,8,,,HATs acetylate histones,3,High,1
O15514,DNA-directed RNA polymerase II subunit RPB4 OS=Homo sapiens OX=9606 GN=POLR2D PE=1 SV=1,0.001,10.724,25,2,6,2,142,16.3,4.79,2798,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding,Pf03874,5433,ENSG00000144231.10,POLR2D,2,Metabolic pathways; Huntington's disease; RNA polymerase; Epstein-Barr virus infection; Pyrimidine metabolism; Purine metabolism,,Signaling by FGFR2 IIIa TM; RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Formation of HIV-1 elongation complex containing HIV-1 Tat; MicroRNA (miRNA) biogenesis; Formation of the HIV-1 Early Elongation Complex; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; TP53 Regulates Transcription of DNA Repair Genes; Transcriptional regulation by small RNAs; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; RNA Polymerase II HIV Promoter Escape; Formation of HIV elongation complex in the absence of HIV Tat; Transcriptional regulation of pluripotent stem cells; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; Formation of TC-NER Pre-Incision Complex; Pausing and recovery of HIV elongation; RNA Polymerase II Promoter Escape; HIV elongation arrest and recovery; RNA Pol II CTD phosphorylation and interaction with CE; Viral Messenger RNA Synthesis; RNA Polymerase II Transcription Initiation; mRNA Capping; Dual incision in TC-NER; PIWI-interacting RNA (piRNA) biogenesis; Pausing and recovery of Tat-mediated HIV elongation; Formation of the Early Elongation Complex,74,High,1
Q9UK45,U6 snRNA-associated Sm-like protein LSm7 OS=Homo sapiens OX=9606 GN=LSM7 PE=1 SV=1,0.001,10.709,9,2,15,2,103,11.6,5.27,6169,,2,,metabolic process,cytosol;nucleus;spliceosomal complex,protein binding;RNA binding,Pf01423,51690,ENSG00000130332.14,LSM7,19,Spliceosome; RNA degradation,mRNA Processing,mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease,9,High,1
Q7Z7L1,Schlafen family member 11 OS=Homo sapiens OX=9606 GN=SLFN11 PE=1 SV=2,0.001,10.696,3,2,8,1,901,102.8,7.77,3169,,2,,defense response;regulation of biological process;response to stimulus,cytosol;nucleus,catalytic activity;DNA binding;nucleotide binding;RNA binding,"Pf04326, Pf04851, Pf09848, Pf13173, Pf13401",91607,ENSG00000172716.16,SLFN11,17,,,,0,High,1
Q9NTM9,Copper homeostasis protein cutC homolog OS=Homo sapiens OX=9606 GN=CUTC PE=1 SV=1,0.001,10.686,10,2,12,2,273,29.3,8.18,4501,,2,,cell organization and biogenesis;transport,cytoplasm;cytosol;nucleus,metal ion binding;protein binding,Pf03932,51076,ENSG00000119929.12,CUTC,10,,,Ion transport by P-type ATPases,3,High,1
Q5T3F8,CSC1-like protein 2 OS=Homo sapiens OX=9606 GN=TMEM63B PE=1 SV=1,0.001,10.684,4,4,31,4,832,94.9,7.4,11528,,4,,transport,cytoskeleton;membrane,transporter activity,"Pf02714, Pf13967, Pf14703",55362,ENSG00000137216.18,TMEM63B,6,,,,0,High,1
O95236,Apolipoprotein L3 OS=Homo sapiens OX=9606 GN=APOL3 PE=1 SV=3,0.001,10.684,10,3,12,3,402,44.3,8.16,4269,,3,,defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;extracellular;membrane,signal transducer activity;transporter activity,Pf05461,80833,ENSG00000128284.19,APOL3,22,,,,0,High,1
O60337,E3 ubiquitin-protein ligase MARCH6 OS=Homo sapiens OX=9606 GN=MARCH6 PE=1 SV=2,0.001,10.68,5,2,3,2,910,102.5,6.28,1404,,2,,metabolic process,endoplasmic reticulum;membrane,catalytic activity;metal ion binding;protein binding,Pf12906,10299,ENSG00000145495.15,MARCH6,5,Protein processing in endoplasmic reticulum,,ER Quality Control Compartment (ERQC),7,High,1
Q9NQC7,Ubiquitin carboxyl-terminal hydrolase CYLD OS=Homo sapiens OX=9606 GN=CYLD PE=1 SV=1,0.001,10.676,6,4,13,4,956,107.2,5.59,3377,,4,,cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane,catalytic activity;metal ion binding;protein binding;structural molecule activity,Pf01302,1540,ENSG00000083799.17,CYLD,16,Osteoclast differentiation; RIG-I-like receptor signaling pathway,Regulation of toll-like receptor signaling pathway; RIG-I-like Receptor Signaling,Ub-specific processing proteases; NOD1/2 Signaling Pathway; Negative regulators of DDX58/IFIH1 signaling; TNFR1-induced proapoptotic signaling; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway,20,High,1
Q3KQZ1,Solute carrier family 25 member 35 OS=Homo sapiens OX=9606 GN=SLC25A35 PE=2 SV=1,0.001,10.662,6,2,17,2,300,32.4,9.11,8643,,2,,transport,membrane;mitochondrion,transporter activity,Pf00153,399512,ENSG00000125434.10,SLC25A35,17,,,,0,High,1
P51793,H(+)/Cl(-) exchange transporter 4 OS=Homo sapiens OX=9606 GN=CLCN4 PE=1 SV=2,0.001,10.648,5,4,12,2,760,84.9,6.86,5370,0,3,1,transport,endoplasmic reticulum;endosome;membrane,nucleotide binding;transporter activity,"Pf00571, Pf00654",1183,ENSG00000073464.11,CLCN4,X,,,Stimuli-sensing channels,3,High,1
Q9BSF0,Small membrane A-kinase anchor protein OS=Homo sapiens OX=9606 GN=C2orf88 PE=1 SV=2,0.001,10.647,36,3,9,3,95,11,4.87,3207,,3,,,membrane,protein binding,Pf15127,84281,ENSG00000187699.10,C2orf88,2,,,,0,High,1
Q15166,Serum paraoxonase/lactonase 3 OS=Homo sapiens OX=9606 GN=PON3 PE=1 SV=3,0.001,10.636,5,3,22,2,354,39.6,5.41,7322,,3,,metabolic process;regulation of biological process;response to stimulus,extracellular,catalytic activity;metal ion binding;protein binding,"Pf01731, Pf03088",5446,ENSG00000105852.10,PON3,7,Metabolic pathways,"Phase I biotransformations, non P450",Synthesis of 5-eicosatetraenoic acids,7,High,1
Q9UGJ1,Gamma-tubulin complex component 4 OS=Homo sapiens OX=9606 GN=TUBGCP4 PE=1 SV=1,0.001,10.628,9,3,5,3,667,76,6.65,1459,,3,,cell organization and biogenesis,cytoplasm;cytoskeleton;cytosol;endosome;membrane,protein binding;structural molecule activity,Pf04130,27229,ENSG00000137822.12,TUBGCP4,15,,,Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes,9,High,1
Q8IUA7,ATP-binding cassette sub-family A member 9 OS=Homo sapiens OX=9606 GN=ABCA9 PE=1 SV=1,0.001,10.622,2,3,12,1,1624,184.2,6.93,5214,1.93,3,1,transport,membrane;mitochondrion,catalytic activity;nucleotide binding;transporter activity,"Pf00005, Pf02653, Pf03193, Pf12698, Pf13304",10350,ENSG00000154258.16,ABCA9,17,ABC transporters,,ABC transporters in lipid homeostasis,4,High,1
Q70UQ0-4,Isoform 4 of Inhibitor of nuclear factor kappa-B kinase-interacting protein OS=Homo sapiens OX=9606 GN=IKBIP,0.001,10.619,7,2,6,1,377,43.1,4.92,713,10.37,1,1,response to stimulus,endoplasmic reticulum;membrane,protein binding,"Pf10146, Pf12128, Pf13166",121457,ENSG00000166130.14,IKBIP,12,,,,0,High,1
Q2TAZ0,Autophagy-related protein 2 homolog A OS=Homo sapiens OX=9606 GN=ATG2A PE=1 SV=3,0.001,10.609,2,3,19,3,1938,212.7,5.88,7155,,3,,cell organization and biogenesis;metabolic process,cytosol;membrane;nucleus,protein binding,"Pf09333, Pf12624",23130,ENSG00000110046.12,ATG2A,11,,,,0,High,1
Q96NC0,Zinc finger matrin-type protein 2 OS=Homo sapiens OX=9606 GN=ZMAT2 PE=1 SV=1,0.001,10.604,13,3,11,3,199,23.6,9.01,4922,,3,,cell organization and biogenesis;metabolic process,nucleus,DNA binding;metal ion binding;protein binding;RNA binding,"Pf12171, Pf12874",153527,ENSG00000146007.10,ZMAT2,5,Spliceosome,,,1,High,1
Q9P2D3,HEAT repeat-containing protein 5B OS=Homo sapiens OX=9606 GN=HEATR5B PE=1 SV=2,0.001,10.595,2,3,7,3,2071,224.2,7.17,2112,,3,,,membrane,,,54497,ENSG00000008869.11,HEATR5B,2,,,,0,High,1
O95873,Uncharacterized protein C6orf47 OS=Homo sapiens OX=9606 GN=C6orf47 PE=1 SV=2,0.001,10.59,7,4,10,4,294,31.7,6.37,2970,,4,,,cytosol,,Pf15576,57827,ENSG00000228177.2; ENSG00000204439.3,C6orf47,6; CHR_HSCHR6_MHC_MANN_CTG1,,,,0,High,1
Q6ZN55,Zinc finger protein 574 OS=Homo sapiens OX=9606 GN=ZNF574 PE=1 SV=2,0.001,10.563,3,3,81,2,896,98.8,8.07,44955,,3,,metabolic process;regulation of biological process,nucleus,DNA binding;metal ion binding,Pf13465,64763,ENSG00000105732.12,ZNF574,19,,,,0,High,1
Q9NUQ2,1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon OS=Homo sapiens OX=9606 GN=AGPAT5 PE=1 SV=3,0.001,10.562,9,2,10,2,364,42,9.1,4934,,2,,cell differentiation;metabolic process,endoplasmic reticulum;membrane;mitochondrion;nucleus,catalytic activity;protein binding,Pf01553,55326,ENSG00000155189.11,AGPAT5,8,Glycerophospholipid metabolism; Glycerolipid metabolism; Metabolic pathways; Phospholipase D signaling pathway,Triacylglyceride Synthesis,Synthesis of PA,10,High,1
P32321,Deoxycytidylate deaminase OS=Homo sapiens OX=9606 GN=DCTD PE=1 SV=2,0.001,10.538,11,2,7,2,178,20,7.56,3169,,2,,metabolic process,cytoplasm;cytosol,catalytic activity;metal ion binding;protein binding,Pf00383,1635,ENSG00000129187.14,DCTD,4,Pyrimidine metabolism; Metabolic pathways,,Interconversion of nucleotide di- and triphosphates,5,High,1
P38935,DNA-binding protein SMUBP-2 OS=Homo sapiens OX=9606 GN=IGHMBP2 PE=1 SV=3,0.001,10.533,8,4,7,4,993,109.1,8.97,1536,,4,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;membrane;nucleus,catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding,"Pf01424, Pf01428, Pf13086, Pf13087",3508,ENSG00000132740.8,IGHMBP2,11,,,,0,High,1
O94763,Unconventional prefoldin RPB5 interactor 1 OS=Homo sapiens OX=9606 GN=URI1 PE=1 SV=3,0.001,10.529,7,2,12,2,535,59.8,5.05,5323,,2,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;mitochondrion;nucleus,enzyme regulator activity;protein binding,"Pf02996, Pf13758",8725,ENSG00000105176.17,URI1,19,,,,0,High,1
Q9NP66,High mobility group protein 20A OS=Homo sapiens OX=9606 GN=HMG20A PE=1 SV=1,0.001,10.52,11,2,8,2,347,40.1,6.49,3089,,2,,cell organization and biogenesis;metabolic process;regulation of biological process,nucleus,DNA binding;protein binding,"Pf00505, Pf09011",10363,ENSG00000140382.14,HMG20A,15,,,,0,High,1
Q6ZRP7,Sulfhydryl oxidase 2 OS=Homo sapiens OX=9606 GN=QSOX2 PE=1 SV=3,0.001,10.517,5,3,9,3,698,77.5,7.72,3045,,3,,cellular homeostasis;metabolic process;regulation of biological process,extracellular;Golgi;membrane;nucleus,catalytic activity,"Pf00085, Pf04777",169714,ENSG00000165661.16,QSOX2,9,,,,0,High,1
Q96KQ4,Apoptosis-stimulating of p53 protein 1 OS=Homo sapiens OX=9606 GN=PPP1R13B PE=1 SV=3,0.001,10.508,2,2,23,2,1090,119.5,6.76,8525,,2,,cell death;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;mitochondrion;nucleus,protein binding,"Pf00018, Pf00023, Pf07653, Pf10498, Pf12796, Pf13606, Pf13637, Pf13857, Pf14604",23368,ENSG00000088808.16,PPP1R13B,14,,,Regulation of TP53 Activity through Association with Co-factors; TP53 Regulates Transcription of Death Receptors and Ligands; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; Activation of PUMA and translocation to mitochondria,15,High,1
O75881,Cytochrome P450 7B1 OS=Homo sapiens OX=9606 GN=CYP7B1 PE=1 SV=2,0.001,10.5,10,3,6,3,506,58.2,8.02,2254,,3,,cellular component movement;metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;membrane,catalytic activity;metal ion binding,Pf00067,9420,ENSG00000172817.3,CYP7B1,8,Primary bile acid biosynthesis; Steroid hormone biosynthesis,Oxidation by Cytochrome P450; Tryptophan metabolism; Metapathway biotransformation,"Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3); Endogenous sterols; Synthesis of bile acids and bile salts via 27-hydroxycholesterol; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol",20,High,1
Q9Y6F6-1,Isoform 1 of Protein MRVI1 OS=Homo sapiens OX=9606 GN=MRVI1,0.001,10.492,3,2,3,2,885,96.1,5.58,1495,,2,,,cytoplasm;endoplasmic reticulum;membrane,protein binding,Pf05781,10335,,MRVI1,11,Vascular smooth muscle contraction; cGMP-PKG signaling pathway,,cGMP effects,6,High,1
Q8IXK0,Polyhomeotic-like protein 2 OS=Homo sapiens OX=9606 GN=PHC2 PE=1 SV=1,0.001,10.484,2,2,6,2,858,90.7,8.69,2800,,2,,development,nucleus,DNA binding;metal ion binding;protein binding,"Pf00536, Pf07647",1912,ENSG00000134686.18,PHC2,1,,,RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; SUMOylation of chromatin organization proteins; Regulation of PTEN gene transcription; SUMOylation of DNA damage response and repair proteins; Oxidative Stress Induced Senescence; SUMOylation of RNA binding proteins,21,High,1
Q9NVM4,Protein arginine N-methyltransferase 7 OS=Homo sapiens OX=9606 GN=PRMT7 PE=1 SV=1,0.001,10.483,10,3,4,3,692,78.4,5.57,1199,,3,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,Pf06325,54496,ENSG00000132600.16,PRMT7,16,,,RMTs methylate histone arginines,3,High,1
Q13769,THO complex subunit 5 homolog OS=Homo sapiens OX=9606 GN=THOC5 PE=1 SV=2,0.001,10.474,5,2,5,2,683,78.5,6.87,2310,,2,,cell differentiation;metabolic process;regulation of biological process;transport,cytoplasm;nucleus,protein binding;RNA binding,Pf09766,8563,ENSG00000100296.13,THOC5,22,RNA transport,,Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing,10,High,1
Q9BY50,Signal peptidase complex catalytic subunit SEC11C OS=Homo sapiens OX=9606 GN=SEC11C PE=1 SV=3,0.001,10.441,16,3,9,3,192,21.5,9.2,2839,,3,,metabolic process,endoplasmic reticulum;membrane,catalytic activity,Pf00717,90701,ENSG00000166562.8,SEC11C,18,Protein export,,"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Synthesis, secretion, and deacylation of Ghrelin; SRP-dependent cotranslational protein targeting to membrane; Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)",9,High,1
Q15517,Corneodesmosin OS=Homo sapiens OX=9606 GN=CDSN PE=1 SV=3,0.001,10.43,5,2,11,2,529,51.5,8.35,4509,,2,,cell death;cell differentiation;regulation of biological process,cytoskeleton;extracellular;membrane,protein binding,,1041,,CDSN,6,,,Formation of the cornified envelope,3,High,1
P63302,Selenoprotein W OS=Homo sapiens OX=9606 GN=SELENOW PE=1 SV=3,0.001,10.415,10,2,15,2,87,9.4,9.23,6987,,2,,,cytoplasm,antioxidant activity;catalytic activity,Pf10262,6415,ENSG00000178980.14,SEPW1; SELENOW,19,,Selenium Micronutrient Network; Selenium Metabolism and Selenoproteins,,2,High,1
Q96CM3,Mitochondrial RNA pseudouridine synthase RPUSD4 OS=Homo sapiens OX=9606 GN=RPUSD4 PE=1 SV=1,0.001,10.407,5,2,3,2,377,42.2,9.88,1669,,2,,metabolic process,mitochondrion;organelle lumen,catalytic activity;protein binding;RNA binding,Pf00849,84881,ENSG00000165526.8,RPUSD4,11,,,,0,High,1
Q92785,Zinc finger protein ubi-d4 OS=Homo sapiens OX=9606 GN=DPF2 PE=1 SV=2,0.001,10.391,5,2,5,2,391,44.1,6.33,2331,,2,,cell death;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,DNA binding;metal ion binding;protein binding,"Pf00628, Pf14051",5977,ENSG00000133884.9,DPF2,11,,,,0,High,1
Q9UL54,Serine/threonine-protein kinase TAO2 OS=Homo sapiens OX=9606 GN=TAOK2 PE=1 SV=2,0.001,10.384,3,4,14,3,1235,138.2,7.27,4880,,4,,cell death;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf07714, Pf14531",9344,ENSG00000149930.17,TAOK2,16,MAPK signaling pathway,MAPK Signaling Pathway,,2,High,1
P43378,Tyrosine-protein phosphatase non-receptor type 9 OS=Homo sapiens OX=9606 GN=PTPN9 PE=1 SV=1,0.001,10.382,3,2,5,2,593,68,8.02,2727,,2,,metabolic process,cytoplasm,catalytic activity;protein binding,"Pf00102, Pf00650, Pf03765, Pf13716, Pf14566",5780,ENSG00000169410.9,PTPN9,15,,VEGFA-VEGFR2 Signaling Pathway,,1,High,1
P17028,Zinc finger protein 24 OS=Homo sapiens OX=9606 GN=ZNF24 PE=1 SV=4,0.001,10.375,7,2,4,2,368,42.1,6.21,1520,,2,,metabolic process;regulation of biological process,nucleus,DNA binding;metal ion binding;protein binding,"Pf00096, Pf02023, Pf13465",7572,ENSG00000172466.15,ZNF24,18,,,,0,High,1
Q9BZI7,Regulator of nonsense transcripts 3B OS=Homo sapiens OX=9606 GN=UPF3B PE=1 SV=1,0.001,10.356,7,3,12,3,483,57.7,9.48,4690,,3,,metabolic process;regulation of biological process;transport,cytoplasm;cytosol;nucleus,protein binding;RNA binding;transporter activity,Pf03467,65109,ENSG00000125351.11,UPF3B,X,mRNA surveillance pathway; RNA transport,,mRNA 3'-end processing; mRNA Splicing - Major Pathway; Cleavage of Growing Transcript in the Termination Region ; Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC),19,High,1
Q9BW62,Katanin p60 ATPase-containing subunit A-like 1 OS=Homo sapiens OX=9606 GN=KATNAL1 PE=1 SV=1,0.001,10.351,7,4,7,4,490,55.4,6.74,2254,,4,,cell division,cytoplasm;cytoskeleton;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00004, Pf01078, Pf06068, Pf07724, Pf07726, Pf07728, Pf09336, Pf13401, Pf13671",84056,ENSG00000102781.13,KATNAL1,13,,,,0,High,1
P13498,Cytochrome b-245 light chain OS=Homo sapiens OX=9606 GN=CYBA PE=1 SV=3,0.001,10.339,11,2,16,2,195,21,9.54,6036,,2,,cell organization and biogenesis;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;endosome;Golgi;membrane;mitochondrion;nucleus,catalytic activity;metal ion binding;protein binding,Pf05038,1535,ENSG00000051523.10,CYBA,16,Osteoclast differentiation; Leukocyte transendothelial migration; Leishmaniasis; NOD-like receptor signaling pathway; Phagosome,TNF alpha Signaling Pathway; Microglia Pathogen Phagocytosis Pathway; Oxidative Stress,"ROS, RNS production in phagocytes; Neutrophil degranulation; Cross-presentation of particulate exogenous antigens (phagosomes); VEGFA-VEGFR2 Pathway; Detoxification of Reactive Oxygen Species; RHO GTPases Activate NADPH Oxidases",26,High,1
Q8N7R7,Cyclin-Y-like protein 1 OS=Homo sapiens OX=9606 GN=CCNYL1 PE=1 SV=2,0.001,10.336,8,3,4,1,359,40.7,6.07,1770,,3,,cellular component movement;regulation of biological process,membrane,protein binding,"Pf00134, Pf08613",151195,ENSG00000163249.11,CCNYL1,2,,,,0,High,1
O75717,WD repeat and HMG-box DNA-binding protein 1 OS=Homo sapiens OX=9606 GN=WDHD1 PE=1 SV=1,0.001,10.333,3,4,15,4,1129,125.9,5.62,5483,,4,,,cytoplasm;nucleus,DNA binding;protein binding,"Pf00400, Pf00505, Pf08662",11169,ENSG00000198554.11,WDHD1,14,,Mesodermal Commitment Pathway,,1,High,1
Q18PE1,Protein Dok-7 OS=Homo sapiens OX=9606 GN=DOK7 PE=1 SV=1,0.001,10.292,7,2,7,2,504,53.1,6.89,,2.76,,2,regulation of biological process,membrane,protein binding,Pf02174,285489,ENSG00000175920.16,DOK7,4,,,,0,High,1
O95714,E3 ubiquitin-protein ligase HERC2 OS=Homo sapiens OX=9606 GN=HERC2 PE=1 SV=2,0.001,10.288,1,3,5,2,4834,526.9,6.28,1872,,3,,metabolic process;response to stimulus;transport,cytoplasm;cytoskeleton;membrane;nucleus,catalytic activity;metal ion binding;protein binding,"Pf00173, Pf00415, Pf00569, Pf00632, Pf03256, Pf06701, Pf11515, Pf13540",8924,ENSG00000128731.15,HERC2,15,Ubiquitin mediated proteolysis,,G2/M DNA damage checkpoint; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; Nonhomologous End-Joining (NHEJ); Antigen processing: Ubiquitination & Proteasome degradation; SUMOylation of DNA damage response and repair proteins,22,High,1
P38571,Lysosomal acid lipase/cholesteryl ester hydrolase OS=Homo sapiens OX=9606 GN=LIPA PE=1 SV=2,0.001,10.281,13,3,9,3,399,45.4,6.92,2864,,3,,cell organization and biogenesis;cell proliferation;defense response;metabolic process;response to stimulus,organelle lumen;vacuole,catalytic activity,"Pf00561, Pf04083, Pf12695, Pf12697",3988,ENSG00000107798.17,LIPA,10,Lysosome; Steroid biosynthesis,"Phase I biotransformations, non P450",LDL clearance,7,High,1
O43427,Acidic fibroblast growth factor intracellular-binding protein OS=Homo sapiens OX=9606 GN=FIBP PE=1 SV=3,0.001,10.277,10,3,3,3,364,41.9,6.48,1231,,3,,regulation of biological process;response to stimulus,membrane;mitochondrion;nucleus,protein binding,Pf05427,9158,ENSG00000172500.12,FIBP,11,,,,0,High,1
P62837,Ubiquitin-conjugating enzyme E2 D2 OS=Homo sapiens OX=9606 GN=UBE2D2 PE=1 SV=1,0.001,10.271,12,2,27,2,147,16.7,7.83,10938,,2,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00179, Pf14461",7322,ENSG00000131508.15,UBE2D2,5,Protein processing in endoplasmic reticulum; Shigellosis; Ubiquitin mediated proteolysis,Proteasome Degradation,"Downstream TCR signaling; IKK complex recruitment mediated by RIP1; TICAM1, RIP1-mediated IKK complex recruitment ; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Neddylation; Activated TLR4 signalling; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; E3 ubiquitin ligases ubiquitinate target proteins; Negative regulators of DDX58/IFIH1 signaling; CLEC7A (Dectin-1) signaling",36,High,1
P80108,Phosphatidylinositol-glycan-specific phospholipase D OS=Homo sapiens OX=9606 GN=GPLD1 PE=1 SV=3,0.001,10.271,5,3,8,3,840,92.3,6.37,2580,,3,,cell differentiation;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;extracellular;membrane,catalytic activity,"Pf00882, Pf01839, Pf13517",2822,ENSG00000112293.14,GPLD1,6,Glycosylphosphatidylinositol (GPI)-anchor biosynthesis,,Post-translational modification: synthesis of GPI-anchored proteins,4,High,1
Q9NZE8,"39S ribosomal protein L35, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL35 PE=1 SV=3",0.001,10.264,9,2,14,2,188,21.5,11.3,6743,,2,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,structural molecule activity,Pf01632,51318,ENSG00000132313.14,MRPL35,2,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
Q9H1D9,DNA-directed RNA polymerase III subunit RPC6 OS=Homo sapiens OX=9606 GN=POLR3F PE=1 SV=1,0.001,10.262,8,2,6,2,316,35.7,6.11,3282,,2,,defense response;metabolic process;regulation of biological process;response to stimulus,cytosol;nucleus,catalytic activity;DNA binding;protein binding,Pf05158,10621,ENSG00000132664.11,POLR3F,20,Metabolic pathways; Epstein-Barr virus infection; Cytosolic DNA-sensing pathway; Pyrimidine metabolism; RNA polymerase; Purine metabolism,,RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase III Transcription Initiation From Type 2 Promoter,18,High,1
Q12983,BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 OS=Homo sapiens OX=9606 GN=BNIP3 PE=1 SV=3,0.001,10.256,7,2,7,2,259,27.8,7.17,2495,,2,,cell death;cell differentiation;cell organization and biogenesis;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;membrane;mitochondrion;nucleus,protein binding,Pf06553,664,ENSG00000176171.11,BNIP3,10,FoxO signaling pathway; Legionellosis,Photodynamic therapy-induced HIF-1 survival signaling,,3,High,1
Q8IYU8,"Calcium uptake protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=MICU2 PE=1 SV=2",0.001,10.229,10,2,3,2,434,49.6,9.09,631,3.44,1,1,cellular homeostasis;transport,membrane;mitochondrion;nucleus,metal ion binding;protein binding,Pf13833,221154,ENSG00000165487.13,EFHA1; MICU2,13,,,Processing of SMDT1,3,High,1
Q9Y5J6,Mitochondrial import inner membrane translocase subunit Tim10 B OS=Homo sapiens OX=9606 GN=TIMM10B PE=1 SV=1,0.001,10.201,15,1,4,1,103,11.6,7.43,2042,0,1,1,transport,membrane;mitochondrion,metal ion binding;protein binding,Pf02953,26515,ENSG00000132286.11; ENSG00000283977.1,FXC1; TIMM10B,11,,,Mitochondrial protein import; Metabolism of proteins,2,High,1
Q8WXG6,MAP kinase-activating death domain protein OS=Homo sapiens OX=9606 GN=MADD PE=1 SV=2,0.001,10.197,3,3,6,3,1647,183.2,6.04,1744,,3,,cell death;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,enzyme regulator activity;protein binding,"Pf02141, Pf03455, Pf03456",8567,ENSG00000110514.19,MADD,11,,Deregulation of Rab and Rab Effector Genes in Bladder Cancer; TNF alpha Signaling Pathway,,2,High,1
O00422,Histone deacetylase complex subunit SAP18 OS=Homo sapiens OX=9606 GN=SAP18 PE=1 SV=1,0.001,10.194,22,3,10,3,153,17.6,9.35,2954,,3,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;protein binding;RNA binding,Pf06487,10284,ENSG00000150459.12,SAP18,13,mRNA surveillance pathway; RNA transport,Hedgehog Signaling Pathway,HDACs deacetylate histones; NoRC negatively regulates rRNA expression,10,High,1
Q96Q07,BTB/POZ domain-containing protein 9 OS=Homo sapiens OX=9606 GN=BTBD9 PE=1 SV=2,0.001,10.19,4,2,3,2,612,69.1,5.77,1180,,2,,metabolic process;regulation of biological process;response to stimulus,cytoplasm,protein binding,"Pf00651, Pf00754, Pf07707",114781,ENSG00000183826.16,BTBD9,6,,,,0,High,1
O00213,Amyloid-beta A4 precursor protein-binding family B member 1 OS=Homo sapiens OX=9606 GN=APBB1 PE=1 SV=2,0.001,10.174,7,3,4,3,710,77.2,5.06,1728,,3,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;membrane;nucleus,protein binding,"Pf00397, Pf00640",322,ENSG00000166313.18,APBB1,11,Alzheimer's disease,Alzheimers Disease,Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks,6,High,1
Q9Y6B7,AP-4 complex subunit beta-1 OS=Homo sapiens OX=9606 GN=AP4B1 PE=1 SV=2,0.001,10.17,6,2,5,2,739,83.2,5.86,2230,,2,,transport,cytosol;Golgi;membrane;organelle lumen,protein binding;transporter activity,"Pf01602, Pf09066, Pf12717, Pf13646",10717,ENSG00000134262.12,AP4B1,1,Lysosome,,Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis,7,High,1
Q9H4A5,Golgi phosphoprotein 3-like OS=Homo sapiens OX=9606 GN=GOLPH3L PE=1 SV=1,0.001,10.145,9,2,9,2,285,32.7,5.83,3775,,2,,cell organization and biogenesis;regulation of biological process;transport,cytosol;Golgi;membrane,protein binding,"Pf02350, Pf05719",55204,ENSG00000143457.10,GOLPH3L,1,Transcriptional misregulation in cancer,,,1,High,1
Q9UHW5,GPN-loop GTPase 3 OS=Homo sapiens OX=9606 GN=GPN3 PE=1 SV=2,0.001,10.097,6,1,4,1,284,32.7,4.5,2366,0,1,1,,,catalytic activity;nucleotide binding;protein binding,Pf03029,51184,ENSG00000111231.8,GPN3,12,,,,0,High,1
O75044,SLIT-ROBO Rho GTPase-activating protein 2 OS=Homo sapiens OX=9606 GN=SRGAP2 PE=1 SV=3,0.001,10.053,2,2,5,1,1071,120.8,6.7,2746,,2,,,,,,,,,,,,,0,High,1
P60510,Serine/threonine-protein phosphatase 4 catalytic subunit OS=Homo sapiens OX=9606 GN=PPP4C PE=1 SV=1,0.001,10.04,7,2,16,2,307,35.1,5.06,8545,,2,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,catalytic activity;metal ion binding;protein binding;signal transducer activity,Pf00149,5531,ENSG00000149923.13,PPP4C,16,Glucagon signaling pathway,,Processing of DNA double-strand break ends,6,High,1
Q7Z6M1,Rab9 effector protein with kelch motifs OS=Homo sapiens OX=9606 GN=RABEPK PE=1 SV=1,0.001,10.013,9,3,8,3,372,40.5,6.25,3306,,3,,transport,cytoplasm;cytosol;endosome;membrane,protein binding,"Pf01344, Pf07646, Pf13415, Pf13418, Pf13854, Pf13964",10244,ENSG00000136933.16,RABEPK,9,,,Retrograde transport at the Trans-Golgi-Network,4,High,1
P14415,Sodium/potassium-transporting ATPase subunit beta-2 OS=Homo sapiens OX=9606 GN=ATP1B2 PE=1 SV=3,0.001,10.012,11,3,15,2,290,33.3,8.31,4359,,3,,cell communication;cellular component movement;cellular homeostasis;regulation of biological process;transport,cytoplasm;membrane,catalytic activity;enzyme regulator activity;protein binding;transporter activity,Pf00287,482,ENSG00000129244.8,ATP1B2,17,Insulin secretion; Endocrine and other factor-regulated calcium reabsorption; Salivary secretion; Pancreatic secretion; Proximal tubule bicarbonate reclamation; Bile secretion; Mineral absorption; Carbohydrate digestion and absorption; Adrenergic signaling in cardiomyocytes; Cardiac muscle contraction; Thyroid hormone signaling pathway; Gastric acid secretion; Protein digestion and absorption; Aldosterone-regulated sodium reabsorption; cGMP-PKG signaling pathway; Thyroid hormone synthesis; cAMP signaling pathway,Calcium Regulation in the Cardiac Cell,Ion homeostasis; Basigin interactions; Ion transport by P-type ATPases,27,High,1
Q14814,Myocyte-specific enhancer factor 2D OS=Homo sapiens OX=9606 GN=MEF2D PE=1 SV=1,0.001,10.007,7,3,7,3,521,55.9,7.88,2230,,3,,cell death;cell differentiation;development;metabolic process;regulation of biological process,cytoplasm;nucleus,DNA binding;protein binding,"Pf00319, Pf12347",4209,ENSG00000116604.17,MEF2D,1,cGMP-PKG signaling pathway,Energy Metabolism; SRF and miRs in Smooth Muscle Differentiation and Proliferation; miRs in Muscle Cell Differentiation; Cell Differentiation - Index; B Cell Receptor Signaling Pathway; Adipogenesis; p38 MAPK Signaling Pathway; EGF/EGFR Signaling Pathway,Transcriptional activation of mitochondrial biogenesis; CDO in myogenesis; Circadian Clock,16,High,1
Q8TF72,Protein Shroom3 OS=Homo sapiens OX=9606 GN=SHROOM3 PE=1 SV=2,0.001,9.985,1,3,11,3,1996,216.7,7.8,4845,,3,,cell organization and biogenesis;development;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;membrane,protein binding,"Pf00595, Pf08687, Pf08688",57619,ENSG00000138771.14,SHROOM3,4,Tight junction,,,1,High,1
Q9BRK5,45 kDa calcium-binding protein OS=Homo sapiens OX=9606 GN=SDF4 PE=1 SV=1,0.001,9.983,9,3,10,3,362,41.8,4.86,3765,,3,,cell differentiation;response to stimulus;transport,cytoplasm;endosome;Golgi;membrane;organelle lumen,metal ion binding;protein binding,Pf13499,51150,ENSG00000078808.16,SDF4,1,,,,0,High,1
Q9UH73,Transcription factor COE1 OS=Homo sapiens OX=9606 GN=EBF1 PE=1 SV=2,0.001,9.981,5,3,22,3,591,64.4,8.76,8697,0,3,1,development;metabolic process;regulation of biological process,nucleus,DNA binding;metal ion binding;protein binding,Pf01833,1879,ENSG00000164330.16,EBF1,5,,Adipogenesis; White fat cell differentiation,Transcriptional regulation of white adipocyte differentiation,4,High,1
Q8NEW0,Zinc transporter 7 OS=Homo sapiens OX=9606 GN=SLC30A7 PE=2 SV=1,0.001,9.978,6,2,6,2,376,41.6,6.95,2743,,2,,regulation of biological process;response to stimulus;transport,cytoplasm;Golgi;membrane,transporter activity,Pf01545,148867,ENSG00000162695.11,SLC30A7,1,,Zinc homeostasis,Insulin processing; Zinc efflux and compartmentalization by the SLC30 family,10,High,1
Q9H159,Cadherin-19 OS=Homo sapiens OX=9606 GN=CDH19 PE=2 SV=1,0.001,9.97,4,3,11,3,772,86.9,4.73,3934,,3,,,membrane,metal ion binding,"Pf00028, Pf01049",28513,ENSG00000071991.8,CDH19,18,,,,0,High,1
Q6P4I2,WD repeat-containing protein 73 OS=Homo sapiens OX=9606 GN=WDR73 PE=1 SV=1,0.001,9.964,6,2,51,2,378,41.7,5.78,18502,,2,,cell organization and biogenesis;regulation of biological process,cytoplasm;cytoskeleton;cytosol,protein binding,,84942,ENSG00000177082.12,WDR73,15,,,,0,High,1
Q9BXP2,Solute carrier family 12 member 9 OS=Homo sapiens OX=9606 GN=SLC12A9 PE=1 SV=1,0.001,9.964,5,3,4,3,914,96,8.07,1224,,3,,transport,membrane,transporter activity,"Pf00324, Pf13520",56996,ENSG00000146828.17,SLC12A9,7,,,,0,High,1
P13688,Carcinoembryonic antigen-related cell adhesion molecule 1 OS=Homo sapiens OX=9606 GN=CEACAM1 PE=1 SV=2,0.001,9.96,8,2,14,2,526,57.5,5.97,3777,,2,,cell proliferation;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;extracellular;membrane,protein binding;transporter activity,"Pf00047, Pf07679, Pf07686, Pf13895, Pf13927",634,ENSG00000079385.21,CEACAM1,19,,,Neutrophil degranulation; Fibronectin matrix formation; Cell surface interactions at the vascular wall,7,High,1
Q96MU7,YTH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=YTHDC1 PE=1 SV=3,0.001,9.954,3,2,6,2,727,84.6,6.23,2506,,2,,cell organization and biogenesis;metabolic process;regulation of biological process,membrane;nucleus,protein binding;RNA binding,Pf04146,91746,ENSG00000083896.12; ENSG00000275272.4,YTHDC1,4; CHR_HSCHR4_1_CTG9,,,,0,High,1
Q99972,Myocilin OS=Homo sapiens OX=9606 GN=MYOC PE=1 SV=2,0.001,9.953,8,3,5,3,504,56.9,5.54,750,2.05,2,1,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;extracellular;Golgi;membrane;mitochondrion,catalytic activity;metal ion binding;motor activity;protein binding,"Pf00769, Pf01576, Pf02191, Pf04111, Pf04156, Pf06156, Pf06657, Pf07926, Pf08614, Pf10473, Pf11559, Pf12128, Pf12718, Pf13514",4653,ENSG00000034971.16,MYOC,1,,,,0,High,1
Q8N8R5,UPF0565 protein C2orf69 OS=Homo sapiens OX=9606 GN=C2orf69 PE=1 SV=1,0.001,9.94,9,2,3,2,385,43.4,8.09,1163,,2,,,extracellular,,Pf10561,205327,ENSG00000178074.5,C2orf69,2,,,,0,High,1
Q6PJI9,GATOR complex protein WDR59 OS=Homo sapiens OX=9606 GN=WDR59 PE=1 SV=2,0.001,9.936,4,2,4,2,974,109.7,7.91,1901,,2,,cell communication;regulation of biological process;response to stimulus,membrane;vacuole,metal ion binding;protein binding,"Pf00400, Pf05773, Pf08662, Pf12678, Pf13639",79726,ENSG00000103091.14,WDR59,16,mTOR signaling pathway,,,1,High,1
Q6UXB8,Peptidase inhibitor 16 OS=Homo sapiens OX=9606 GN=PI16 PE=1 SV=1,0.001,9.932,4,2,6,2,463,49.4,5.39,2235,,2,,regulation of biological process,extracellular,enzyme regulator activity,Pf00188,221476,ENSG00000164530.13,PI16,6,,,,0,High,1
Q5JPI3,Uncharacterized protein C3orf38 OS=Homo sapiens OX=9606 GN=C3orf38 PE=1 SV=1,0.001,9.909,6,1,8,1,329,37.5,6.47,4171,,1,,cell death;regulation of biological process,nucleus,,Pf15008,285237,ENSG00000179021.9,C3orf38,3,,,,0,High,1
Q9C0H2,Protein tweety homolog 3 OS=Homo sapiens OX=9606 GN=TTYH3 PE=1 SV=3,0.001,9.909,5,2,7,2,523,57.5,5.39,3187,,2,,transport,membrane,transporter activity,Pf04906,80727,ENSG00000136295.14,TTYH3,7,,,Stimuli-sensing channels,3,High,1
Q9H0J9,Protein mono-ADP-ribosyltransferase PARP12 OS=Homo sapiens OX=9606 GN=PARP12 PE=1 SV=1,0.001,9.908,5,3,4,3,701,79,8.51,1262,,3,,,nucleus,catalytic activity;metal ion binding;RNA binding,"Pf00644, Pf02825",64761,ENSG00000059378.12,PARP12,7,,,,0,High,1
Q13952,Nuclear transcription factor Y subunit gamma OS=Homo sapiens OX=9606 GN=NFYC PE=1 SV=3,0.001,9.902,5,2,3,2,458,50.3,6.1,1377,,2,,metabolic process;regulation of biological process,nucleus,DNA binding;protein binding,"Pf00125, Pf00808",4802,ENSG00000066136.20,NFYC,1,Antigen processing and presentation; Tuberculosis,,ATF4 activates genes; ATF6 (ATF6-alpha) activates chaperone genes; PPARA activates gene expression; Activation of gene expression by SREBF (SREBP),15,High,1
Q8IYB5,Stromal membrane-associated protein 1 OS=Homo sapiens OX=9606 GN=SMAP1 PE=1 SV=2,0.001,9.899,5,2,10,2,467,50.4,8.75,3057,,2,,regulation of biological process,cytoplasm;membrane,enzyme regulator activity;metal ion binding;protein binding,Pf01412,60682,ENSG00000112305.14,SMAP1,6,Endocytosis,,,1,High,1
Q3MII6,TBC1 domain family member 25 OS=Homo sapiens OX=9606 GN=TBC1D25 PE=1 SV=2,0.001,9.884,3,1,2,1,688,76.3,6.16,1430,,1,,metabolic process;regulation of biological process;transport,cytoplasm;vacuole,enzyme regulator activity;protein binding,Pf00566,4943,ENSG00000068354.15,TBC1D25,X,,,TBC/RABGAPs,4,High,1
Q6PD74,Alpha- and gamma-adaptin-binding protein p34 OS=Homo sapiens OX=9606 GN=AAGAB PE=1 SV=1,0.001,9.882,10,2,5,2,315,34.6,4.64,2389,,2,,transport,cytoplasm;cytosol,protein binding,Pf10199,79719,ENSG00000103591.12,AAGAB,15,,,,0,High,1
Q96FX7,tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A OS=Homo sapiens OX=9606 GN=TRMT61A PE=1 SV=1,0.001,9.862,14,3,14,3,289,31.4,7.36,4088,,3,,metabolic process,nucleus,catalytic activity,"Pf08704, Pf12847, Pf13847",115708,ENSG00000166166.12,TRMT61A,14,,,tRNA modification in the nucleus and cytosol,3,High,1
Q8WUF8,Cotranscriptional regulator FAM172A OS=Homo sapiens OX=9606 GN=FAM172A PE=2 SV=1,0.001,9.847,6,3,8,3,416,47.9,6.09,3303,,3,,,endoplasmic reticulum;extracellular,,Pf09757,83989,ENSG00000113391.18,FAM172A,5,,,,0,High,1
P28907,ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 OS=Homo sapiens OX=9606 GN=CD38 PE=1 SV=2,0.001,9.834,7,2,14,2,300,34.3,7.66,4437,,2,,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cell surface;membrane;nucleus,catalytic activity;protein binding,Pf02267,952,ENSG00000004468.12,CD38,4,Calcium signaling pathway; Pancreatic secretion; Nicotinate and nicotinamide metabolism; Epstein-Barr virus infection; Metabolic pathways; Salivary secretion; Oxytocin signaling pathway; Hematopoietic cell lineage,NAD+ metabolism; NAD+ biosynthetic pathways; Cell-type Dependent Selectivity of CCK2R Signaling,Nicotinate metabolism,15,High,1
Q676U5,Autophagy-related protein 16-1 OS=Homo sapiens OX=9606 GN=ATG16L1 PE=1 SV=2,0.001,9.833,5,3,6,3,607,68.2,6.64,1937,,3,,cell communication;cell organization and biogenesis;metabolic process;response to stimulus;transport,cytoplasm;cytosol;membrane;vacuole,catalytic activity;protein binding,"Pf00400, Pf00769, Pf03938, Pf07888, Pf08317, Pf08450, Pf08614, Pf09726",55054,ENSG00000281089.2; ENSG00000085978.21,ATG16L1,2; CHR_HG2232_PATCH,Autophagy; NOD-like receptor signaling pathway,Nanoparticle triggered autophagic cell death; Senescence and Autophagy in Cancer,Macroautophagy,6,High,1
Q5VT79,Annexin A8-like protein 1 OS=Homo sapiens OX=9606 GN=ANXA8L1 PE=2 SV=2,0.001,9.831,4,2,67,1,327,36.9,5.78,24294,0,2,1,,,metal ion binding,Pf00191,728113,ENSG00000264230.7,ANXA8L1,10,,,,0,High,1
Q9UKV5,E3 ubiquitin-protein ligase AMFR OS=Homo sapiens OX=9606 GN=AMFR PE=1 SV=2,0.001,9.811,3,2,17,2,643,72.9,6.39,5626,,2,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;endoplasmic reticulum;Golgi;membrane;nucleus,catalytic activity;metal ion binding;protein binding;receptor activity,"Pf00097, Pf02845, Pf12678, Pf12861, Pf13639, Pf13920, Pf13923, Pf14634, Pf15227",267,ENSG00000159461.14,AMFR,16,Protein processing in endoplasmic reticulum,Sterol Regulatory Element-Binding Proteins (SREBP) signalling,ER Quality Control Compartment (ERQC),8,High,1
Q9NYB9,Abl interactor 2 OS=Homo sapiens OX=9606 GN=ABI2 PE=1 SV=1,0.001,9.803,9,3,8,2,513,55.6,6.16,2209,,3,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol,DNA binding;enzyme regulator activity;protein binding,"Pf00018, Pf07653, Pf07815, Pf14604",10152,,ABI2,2,Regulation of actin cytoskeleton,Regulation of Actin Cytoskeleton,Regulation of actin dynamics for phagocytic cup formation; VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs,13,High,1
B0I1T2,Unconventional myosin-Ig OS=Homo sapiens OX=9606 GN=MYO1G PE=1 SV=2,0.001,9.803,3,2,5,1,1018,116.4,8.73,2437,,2,,cellular component movement;regulation of biological process;response to stimulus;transport,membrane,catalytic activity;motor activity;nucleotide binding;protein binding,"Pf00063, Pf06017",64005,ENSG00000136286.14,MYO1G,7,,,,0,High,1
O00154,Cytosolic acyl coenzyme A thioester hydrolase OS=Homo sapiens OX=9606 GN=ACOT7 PE=1 SV=3,0.001,9.799,10,3,16,3,380,41.8,8.54,7245,,3,,metabolic process,cytoplasm;cytosol;mitochondrion,catalytic activity;protein binding,Pf03061,11332,ENSG00000097021.19,ACOT7,1,Fatty acid elongation; Biosynthesis of unsaturated fatty acids,,Mitochondrial Fatty Acid Beta-Oxidation,6,High,1
P52569,Cationic amino acid transporter 2 OS=Homo sapiens OX=9606 GN=SLC7A2 PE=1 SV=2,0.001,9.797,4,3,7,3,658,71.6,7.28,2622,,3,,metabolic process;regulation of biological process;transport,membrane,transporter activity,"Pf00324, Pf13520, Pf13906",6542,ENSG00000003989.17,SLC7A2,8,,,Amino acid transport across the plasma membrane,4,High,1
O60499,Syntaxin-10 OS=Homo sapiens OX=9606 GN=STX10 PE=1 SV=1,0.001,9.787,16,3,6,3,249,28.1,4.89,1988,,3,,cell organization and biogenesis;regulation of biological process;transport,cytosol;Golgi;membrane,protein binding,"Pf05739, Pf09177",8677,ENSG00000104915.14,STX10,19,SNARE interactions in vesicular transport,,Retrograde transport at the Trans-Golgi-Network,5,High,1
Q9C075,"Keratin, type I cytoskeletal 23 OS=Homo sapiens OX=9606 GN=KRT23 PE=1 SV=2",0.001,9.781,8,3,100,3,422,48.1,6.54,55015,,3,,cell death,cytosol,structural molecule activity,Pf00038,25984,ENSG00000108244.16; ENSG00000263309.6,KRT23,17; CHR_HSCHR17_4_CTG4,,,Formation of the cornified envelope,3,High,1
P35219,Carbonic anhydrase-related protein OS=Homo sapiens OX=9606 GN=CA8 PE=1 SV=3,0.001,9.751,10,2,4,2,290,33,4.86,1736,,2,,metabolic process;regulation of biological process;response to stimulus,cytoplasm,catalytic activity;metal ion binding;protein binding,Pf00194,767,ENSG00000178538.9,CA8,8,Nitrogen metabolism,,,1,High,1
P78332,RNA-binding protein 6 OS=Homo sapiens OX=9606 GN=RBM6 PE=1 SV=5,0.001,9.734,3,3,9,3,1123,128.6,6.32,3318,,3,,metabolic process,nucleus,DNA binding;protein binding;RNA binding,"Pf01585, Pf14259",10180,ENSG00000004534.14,RBM6,3,,,,0,High,1
Q9HBL8,NmrA-like family domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NMRAL1 PE=1 SV=1,0.001,9.731,15,4,4,4,299,33.3,7.52,1048,,4,,metabolic process;transport,cytoplasm;cytosol;nucleus,protein binding,"Pf00106, Pf02254, Pf05368, Pf13460",57407,ENSG00000153406.13; ENSG00000274684.4,NMRAL1,16; CHR_HSCHR16_3_CTG1,,,Urea cycle,4,High,1
Q9BV44,THUMP domain-containing protein 3 OS=Homo sapiens OX=9606 GN=THUMPD3 PE=1 SV=1,0.001,9.715,5,2,5,2,507,57,6.37,2051,,2,,metabolic process,cytosol,catalytic activity;RNA binding,"Pf01170, Pf02926, Pf13659",25917,ENSG00000134077.15,THUMPD3,3,,,,0,High,1
Q96CB9,5-methylcytosine rRNA methyltransferase NSUN4 OS=Homo sapiens OX=9606 GN=NSUN4 PE=1 SV=2,0.001,9.683,8,3,8,3,384,43.1,8.18,3010,,3,,cell organization and biogenesis;metabolic process;regulation of biological process,mitochondrion;organelle lumen,catalytic activity;protein binding;RNA binding,"Pf01189, Pf12847, Pf13659",387338,ENSG00000117481.10,NSUN4,1,,,rRNA modification in the mitochondrion,4,High,1
Q6GMR7,Fatty-acid amide hydrolase 2 OS=Homo sapiens OX=9606 GN=FAAH2 PE=2 SV=1,0.001,9.676,2,2,82,2,532,58.3,9.07,44705,,2,,metabolic process,membrane,catalytic activity,Pf01425,158584,ENSG00000165591.6,FAAH2,X,,,Arachidonic acid metabolism,4,High,1
Q68DU8,BTB/POZ domain-containing protein KCTD16 OS=Homo sapiens OX=9606 GN=KCTD16 PE=1 SV=1,0.001,9.669,4,2,13,1,428,49.1,8.09,5322,,2,,cell organization and biogenesis;regulation of biological process,membrane,protein binding,Pf02214,57528,ENSG00000183775.10,KCTD16,5,,,,0,High,1
Q6XE24,"RNA-binding motif, single-stranded-interacting protein 3 OS=Homo sapiens OX=9606 GN=RBMS3 PE=1 SV=1",0.001,9.665,6,2,7,2,437,47.8,8.03,3680,,2,,defense response;regulation of biological process;response to stimulus,cytoplasm,RNA binding,"Pf00076, Pf13893, Pf14259",27303,ENSG00000144642.21,RBMS3,3,,,,0,High,1
A7E2V4,Zinc finger SWIM domain-containing protein 8 OS=Homo sapiens OX=9606 GN=ZSWIM8 PE=1 SV=1,0.001,9.654,2,2,11,2,1837,197.2,6.8,4536,,2,,,,metal ion binding,,23053,ENSG00000214655.10,ZSWIM8,10,,,Regulation of expression of SLITs and ROBOs,4,High,1
O14772,Fucose-1-phosphate guanylyltransferase OS=Homo sapiens OX=9606 GN=FPGT PE=1 SV=3,0.001,9.652,5,2,3,1,607,68,6.87,1221,,2,,,,,,,,,,,,,0,High,1
Q6UXH9,Inactive serine protease PAMR1 OS=Homo sapiens OX=9606 GN=PAMR1 PE=1 SV=1,0.001,9.632,4,3,10,3,720,80.1,7.46,3289,,3,,metabolic process,extracellular,catalytic activity;metal ion binding;protein binding,"Pf00008, Pf00084, Pf00089, Pf00431",25891,ENSG00000149090.11,PAMR1,11,,,,0,High,1
P06493,Cyclin-dependent kinase 1 OS=Homo sapiens OX=9606 GN=CDK1 PE=1 SV=3,0.001,9.63,15,4,91,3,297,34.1,8.4,30185,,4,,cell death;cell differentiation;cell division;cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus;organelle lumen,catalytic activity;nucleotide binding;protein binding;receptor activity,"Pf00069, Pf01636, Pf07714, Pf14531",983,ENSG00000170312.15,CDK1,10,Oocyte meiosis; Epstein-Barr virus infection; Gap junction; Herpes simplex infection; p53 signaling pathway; Progesterone-mediated oocyte maturation; Viral carcinogenesis; Cell cycle,miRNA Regulation of DNA Damage Response; Cell Cycle; Regulation of Microtubule Cytoskeleton; Spinal Cord Injury; Retinoblastoma (RB) in Cancer; ATM Signaling Pathway; PPAR Alpha Pathway; TGF-beta Signaling Pathway; ATM Signaling Network in Development and Disease; G1 to S cell cycle control; DNA Damage Response,"Regulation of PLK1 Activity at G2/M Transition; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Recruitment of NuMA to mitotic centrosomes; Ovarian tumor domain proteases; Loss of Nlp from mitotic centrosomes; Activation of E2F1 target genes at G1/S; MASTL Facilitates Mitotic Progression; Golgi Cisternae Pericentriolar Stack Reorganization; Activation of NIMA Kinases NEK9, NEK6, NEK7; The role of GTSE1 in G2/M progression after G2 checkpoint; Nuclear Pore Complex (NPC) Disassembly; Transcriptional regulation by RUNX2; Interleukin-20 family signaling; APC/C:Cdc20 mediated degradation of Cyclin B; G2/M DNA replication checkpoint; Condensation of Prometaphase Chromosomes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Regulation of TP53 Degradation; Phosphorylation of Emi1; MAPK3 (ERK1) activation; Recruitment of mitotic centrosome proteins and complexes; Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes; E2F-enabled inhibition of pre-replication complex formation; Phosphorylation of the APC/C; Depolymerisation of the Nuclear Lamina; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; Resolution of Sister Chromatid Cohesion; Condensation of Prophase Chromosomes; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; MAPK6/MAPK4 signaling",95,High,1
P40937,Replication factor C subunit 5 OS=Homo sapiens OX=9606 GN=RFC5 PE=1 SV=1,0.001,9.626,10,3,8,3,340,38.5,7.2,2929,,3,,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding,"Pf00004, Pf03215, Pf05496, Pf06068, Pf08542, Pf13086, Pf13173, Pf13177, Pf13401, Pf13479",5985,ENSG00000111445.13,RFC5,12,Mismatch repair; Nucleotide excision repair; DNA replication,Retinoblastoma (RB) in Cancer; DNA Replication,Translesion Synthesis by POLH; Termination of translesion DNA synthesis; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Polymerase switching on the C-strand of the telomere; Regulation of TP53 Activity through Phosphorylation; PCNA-Dependent Long Patch Base Excision Repair; G2/M DNA damage checkpoint; Translesion synthesis by POLK; Gap-filling DNA repair synthesis and ligation in TC-NER; Presynaptic phase of homologous DNA pairing and strand exchange; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Polymerase switching; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA),57,High,1
Q8NBV4,Inactive phospholipid phosphatase 7 OS=Homo sapiens OX=9606 GN=PLPP7 PE=2 SV=1,0.001,9.621,10,2,5,2,271,29.4,9.94,2260,,2,,regulation of biological process,endoplasmic reticulum;membrane;nucleus,,Pf01569,84814,ENSG00000160539.4,PPAPDC3; PLPP7,9,,,,0,High,1
Q9UMR5,Lysosomal thioesterase PPT2 OS=Homo sapiens OX=9606 GN=PPT2 PE=1 SV=4,0.001,9.616,7,2,10,2,302,34.2,6.33,4657,,2,,metabolic process,organelle lumen;vacuole,catalytic activity,"Pf00561, Pf02089, Pf12697",9374,ENSG00000221988.12,PPT2,6,Fatty acid elongation; Metabolic pathways; Lysosome; Fatty acid metabolism,,Fatty acyl-CoA biosynthesis,8,High,1
Q96Q27,Ankyrin repeat and SOCS box protein 2 OS=Homo sapiens OX=9606 GN=ASB2 PE=1 SV=1,0.001,9.609,7,3,4,3,587,65,7.62,,8.21,,3,cell differentiation;metabolic process;regulation of biological process;response to stimulus,cytosol,catalytic activity;protein binding,"Pf00023, Pf07525, Pf12796, Pf13606, Pf13637, Pf13857",51676,ENSG00000278693.3; ENSG00000100628.11,ASB2,14; CHR_HSCHR14_7_CTG1,,,Antigen processing: Ubiquitination & Proteasome degradation; Neddylation,7,High,1
P52298,Nuclear cap-binding protein subunit 2 OS=Homo sapiens OX=9606 GN=NCBP2 PE=1 SV=1,0.001,9.608,17,3,13,3,156,18,8.21,4404,,3,,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",22916,ENSG00000114503.10,NCBP2,3,Spliceosome; mRNA surveillance pathway; RNA transport,mRNA Processing,Signaling by FGFR2 IIIa TM; RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Formation of the HIV-1 Early Elongation Complex; SLBP independent Processing of Histone Pre-mRNAs; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Cleavage of Growing Transcript in the Termination Region ; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase II Pre-transcription Events; snRNP Assembly; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Transport of the SLBP independent Mature mRNA; mRNA 3'-end processing; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; mRNA Capping; Regulation of expression of SLITs and ROBOs; Processing of Intronless Pre-mRNAs; Transport of Mature mRNA derived from an Intron-Containing Transcript; Formation of the Early Elongation Complex,61,High,1
Q8IXQ6,Protein mono-ADP-ribosyltransferase PARP9 OS=Homo sapiens OX=9606 GN=PARP9 PE=1 SV=2,0.001,9.599,6,3,5,3,854,96.3,7.91,1757,,3,,cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;mitochondrion;nucleus,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding,Pf01661,83666,ENSG00000138496.16,PARP9,3,,,Nicotinamide salvaging,5,High,1
Q9NRR3,CDC42 small effector protein 2 OS=Homo sapiens OX=9606 GN=CDC42SE2 PE=1 SV=1,0.001,9.597,44,1,1,1,84,9.2,8.35,685,,1,,regulation of biological process;transport,cytoplasm;cytoskeleton;membrane,protein binding;structural molecule activity,Pf00786,56990,ENSG00000158985.13,CDC42SE2,5,,,,0,High,1
Q9Y508,E3 ubiquitin-protein ligase RNF114 OS=Homo sapiens OX=9606 GN=RNF114 PE=1 SV=1,0.001,9.586,18,3,7,3,228,25.7,7.25,2678,0,2,1,cell differentiation;development;metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;nucleus,catalytic activity;metal ion binding;protein binding,"Pf00097, Pf05605, Pf13445, Pf13639, Pf13920, Pf13923, Pf14634, Pf15227",55905,ENSG00000124226.10,RNF114,20,,,Antigen processing: Ubiquitination & Proteasome degradation,4,High,1
Q9HAY6,"Beta,beta-carotene 15,15'-dioxygenase OS=Homo sapiens OX=9606 GN=BCO1 PE=1 SV=1",0.001,9.568,1,1,10,1,547,62.6,6.67,7520,,1,,metabolic process,cytosol,catalytic activity;metal ion binding,Pf03055,53630,ENSG00000135697.9,BCMO1; BCO1,16,Retinol metabolism; Metabolic pathways,Vitamin A and Carotenoid Metabolism,Signaling by GPCR; Retinoid metabolism and transport,10,High,1
P10163,Basic salivary proline-rich protein 4 OS=Homo sapiens OX=9606 GN=PRB4 PE=1 SV=4,0.001,9.56,7,2,6,1,310,31.3,10.52,3104,,2,,,extracellular,,,5545,,PRB4,12,,,,0,High,1
P49458,Signal recognition particle 9 kDa protein OS=Homo sapiens OX=9606 GN=SRP9 PE=1 SV=2,0.001,9.56,22,2,11,2,86,10.1,7.97,3983,,2,,cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytosol,protein binding;RNA binding,Pf05486,6726; 653226,ENSG00000143742.12,SRP9; SRP9P1,1; 10,Protein export,,SRP-dependent cotranslational protein targeting to membrane,4,High,1
Q8TEM1,Nuclear pore membrane glycoprotein 210 OS=Homo sapiens OX=9606 GN=NUP210 PE=1 SV=3,0.001,9.553,3,3,8,3,1887,205,6.81,1941,,3,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,endoplasmic reticulum;membrane;nucleus,protein binding,Pf02368,23225,ENSG00000132182.11,NUP210,3,RNA transport,,Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins,64,High,1
Q8IY26,Phospholipid phosphatase 6 OS=Homo sapiens OX=9606 GN=PLPP6 PE=1 SV=3,0.001,9.537,12,2,5,2,295,32.2,9.99,2248,,2,,metabolic process,membrane,catalytic activity;receptor activity;signal transducer activity,Pf01569,403313,ENSG00000205808.5,PPAPDC2; PLPP6,9,,,Cholesterol biosynthesis,4,High,1
Q92851-4,Isoform D of Caspase-10 OS=Homo sapiens OX=9606 GN=CASP10,0.001,9.533,5,2,5,2,522,59,6.62,1261,11.43,1,1,cell death;metabolic process;regulation of biological process;response to stimulus,cytosol,catalytic activity;protein binding,"Pf00656, Pf01335",843,ENSG00000003400.14,CASP10,2,,Apoptosis; Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation; RIG-I-like Receptor Signaling,,3,High,1
Q15113,Procollagen C-endopeptidase enhancer 1 OS=Homo sapiens OX=9606 GN=PCOLCE PE=1 SV=2,0.001,9.531,8,2,7,2,449,47.9,7.43,2280,,2,,development;metabolic process;regulation of biological process,extracellular,enzyme regulator activity;protein binding,"Pf00431, Pf01759",5118,ENSG00000106333.12,PCOLCE,7,,,Collagen biosynthesis and modifying enzymes; Crosslinking of collagen fibrils,5,High,1
Q9UNI6,Dual specificity protein phosphatase 12 OS=Homo sapiens OX=9606 GN=DUSP12 PE=1 SV=1,0.001,9.527,6,2,8,2,340,37.7,6.84,4134,,2,,metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;protein binding,Pf00782,11266,ENSG00000081721.11,DUSP12,1,,,,0,High,1
Q9Y5P8,Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta OS=Homo sapiens OX=9606 GN=PPP2R3B PE=1 SV=2,0.001,9.526,5,3,16,2,575,65,5.14,7437,,3,,metabolic process;regulation of biological process,nucleus,catalytic activity;enzyme regulator activity;metal ion binding;protein binding,Pf13499,28227,ENSG00000167393.17,PPP2R3B,X|Y; X,PI3K-Akt signaling pathway; Dopaminergic synapse; mRNA surveillance pathway; Adrenergic signaling in cardiomyocytes; Sphingolipid signaling pathway; AMPK signaling pathway,Wnt Signaling Pathway and Pluripotency; Glycogen Metabolism,Cyclin D associated events in G1; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Cyclin A/B1/B2 associated events during G2/M transition,19,High,1
Q9Y625,Glypican-6 OS=Homo sapiens OX=9606 GN=GPC6 PE=1 SV=1,0.001,9.502,6,2,9,2,555,62.7,5.41,3020,,2,,cellular component movement;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane;nucleus;organelle lumen,protein binding,Pf01153,10082,ENSG00000183098.10,GPC6,13,,miR-509-3p alteration of YAP1/ECM axis,"Signaling by GPCR; HS-GAG biosynthesis; A tetrasaccharide linker sequence is required for GAG synthesis; Defective B4GALT7 causes EDS, progeroid type; Retinoid metabolism and transport; Defective B3GALT6 causes EDSP2 and SEMDJL1; HS-GAG degradation; Defective EXT2 causes exostoses 2; Defective B3GAT3 causes JDSSDHD; Defective EXT1 causes exostoses 1, TRPS2 and CHDS",23,High,1
O43824,Putative GTP-binding protein 6 OS=Homo sapiens OX=9606 GN=GTPBP6 PE=2 SV=4,0.001,9.487,11,4,14,4,516,56.9,9.42,5566,,4,,,,,,,,,,,,,0,High,1
Q15650,Activating signal cointegrator 1 OS=Homo sapiens OX=9606 GN=TRIP4 PE=1 SV=4,0.001,9.483,5,3,13,3,581,66.1,7.85,4138,,3,,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;nucleus,catalytic activity;metal ion binding;protein binding,"Pf02614, Pf04266, Pf06221",9325,ENSG00000103671.9,TRIP4,15,,,,0,High,1
P34096,Ribonuclease 4 OS=Homo sapiens OX=9606 GN=RNASE4 PE=1 SV=3,0.001,9.474,9,2,12,2,147,16.8,9.03,4516,,2,,metabolic process,extracellular,catalytic activity,Pf00074,6038,ENSG00000258818.3,RNASE4,14,,,,0,High,1
Q8IZV5,Retinol dehydrogenase 10 OS=Homo sapiens OX=9606 GN=RDH10 PE=1 SV=1,0.001,9.472,7,2,5,2,341,38.1,7.4,2400,,2,,metabolic process,cytoplasm;endoplasmic reticulum;membrane;nucleus,catalytic activity,Pf00106,157506,ENSG00000121039.9,RDH10,8,Retinol metabolism; Metabolic pathways,Vitamin A and Carotenoid Metabolism,Signaling by GPCR; The canonical retinoid cycle in rods (twilight vision); RA biosynthesis pathway,10,High,1
Q6BDS2,UHRF1-binding protein 1 OS=Homo sapiens OX=9606 GN=UHRF1BP1 PE=1 SV=1,0.001,9.468,2,2,15,2,1440,159.4,6.14,4573,,2,,,,protein binding,Pf12624,54887,ENSG00000065060.16,UHRF1BP1,6,,,,0,High,1
P19484,Transcription factor EB OS=Homo sapiens OX=9606 GN=TFEB PE=1 SV=3,0.001,9.461,7,2,4,2,476,52.8,6.29,1775,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,DNA binding;protein binding,"Pf00010, Pf11851",7942,ENSG00000112561.17,TFEB,6,,PI3K-AKT-mTOR signaling pathway and therapeutic opportunities,,1,High,1
Q9GZN7,Protein rogdi homolog OS=Homo sapiens OX=9606 GN=ROGDI PE=1 SV=1,0.001,9.429,12,3,3,3,287,32.2,8.16,810,,3,,cell differentiation;regulation of biological process,nucleus,,Pf10259,79641,ENSG00000067836.12,ROGDI,16,,,,0,High,1
Q13416,Origin recognition complex subunit 2 OS=Homo sapiens OX=9606 GN=ORC2 PE=1 SV=2,0.001,9.425,4,2,8,2,577,65.9,6.51,3316,,2,,metabolic process;regulation of biological process,chromosome;membrane;nucleus,DNA binding;protein binding,Pf04084,4999,ENSG00000115942.8,ORC2,2,Cell cycle,Cell Cycle; G1 to S cell cycle control; DNA Replication,M/G1 Transition; CDT1 association with the CDC6:ORC:origin complex; Regulation of DNA replication; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDC6 association with the ORC:origin complex; Association of licensing factors with the pre-replicative complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication; Orc1 removal from chromatin; Removal of licensing factors from origins,28,High,1
Q9NPF5,DNA methyltransferase 1-associated protein 1 OS=Homo sapiens OX=9606 GN=DMAP1 PE=1 SV=1,0.001,9.413,6,2,3,2,467,53,9.5,1638,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,protein binding,Pf05499,55929,ENSG00000178028.13,DMAP1,1,,,HATs acetylate histones,3,High,1
Q86XE5,"4-hydroxy-2-oxoglutarate aldolase, mitochondrial OS=Homo sapiens OX=9606 GN=HOGA1 PE=1 SV=1",0.001,9.406,7,2,9,2,327,35.2,7.96,3954,,2,,metabolic process,mitochondrion;organelle lumen,catalytic activity;protein binding,Pf00701,112817,ENSG00000241935.8,HOGA1,10,Metabolic pathways; Arginine and proline metabolism; Glyoxylate and dicarboxylate metabolism,,Glyoxylate metabolism and glycine degradation,6,High,1
Q8N0V3,"Putative ribosome-binding factor A, mitochondrial OS=Homo sapiens OX=9606 GN=RBFA PE=1 SV=3",0.001,9.404,5,2,12,2,343,38.3,7.85,4824,,2,,metabolic process,mitochondrion,catalytic activity;protein binding,"Pf02033, Pf02637",79863,ENSG00000101546.12,RBFA,18,,,,0,High,1
Q9H0A0,RNA cytidine acetyltransferase OS=Homo sapiens OX=9606 GN=NAT10 PE=1 SV=2,0.001,9.403,2,2,4,2,1025,115.7,8.27,1914,,2,,metabolic process;regulation of biological process,membrane;nucleus,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00583, Pf05127, Pf08351, Pf13508, Pf13718, Pf13725",55226,ENSG00000135372.8,NAT10,11,Ribosome biogenesis in eukaryotes,Metapathway biotransformation,rRNA modification in the nucleus and cytosol,6,High,1
Q9ULE0,Protein WWC3 OS=Homo sapiens OX=9606 GN=WWC3 PE=1 SV=3,0.001,9.397,3,3,10,3,1092,122.6,6.37,3753,,3,,regulation of biological process,cytosol,protein binding;structural molecule activity,"Pf03962, Pf10186, Pf10358",55841,ENSG00000047644.18,WWC3,X,,,,0,High,1
Q16378,Proline-rich protein 4 OS=Homo sapiens OX=9606 GN=PRR4 PE=1 SV=3,0.001,9.384,11,1,54,1,134,15.1,7.06,29039,,1,,,extracellular,,,11272,ENSG00000111215.11; ENSG00000282269.1; ENSG00000263247.6,PRR4,12; CHR_HSCHR12_3_CTG2; CHR_HSCHR12_2_CTG2,,,,0,High,1
O15427,Monocarboxylate transporter 4 OS=Homo sapiens OX=9606 GN=SLC16A3 PE=1 SV=1,0.001,9.383,5,2,6,2,465,49.4,7.96,2540,,2,,cellular component movement;metabolic process;transport,membrane,protein binding;RNA binding;transporter activity,Pf07690,9123,ENSG00000141526.16,SLC16A3,17,Central carbon metabolism in cancer,,Proton-coupled monocarboxylate transport; Basigin interactions; Pyruvate metabolism,12,High,1
Q96EQ0,Small glutamine-rich tetratricopeptide repeat-containing protein beta OS=Homo sapiens OX=9606 GN=SGTB PE=1 SV=1,0.001,9.382,9,2,9,2,304,33.4,4.92,4048,,2,,cell organization and biogenesis;transport,,protein binding,"Pf00515, Pf06552, Pf07719, Pf13181, Pf13414, Pf13424, Pf13431, Pf13432, Pf14559",54557,ENSG00000197860.9,SGTB,5,,,,0,High,1
Q9Y2X8,Ubiquitin-conjugating enzyme E2 D4 OS=Homo sapiens OX=9606 GN=UBE2D4 PE=1 SV=1,0.001,9.377,12,2,5,2,147,16.6,7.37,2260,,2,,metabolic process,,catalytic activity;nucleotide binding;protein binding,"Pf00179, Pf05773, Pf14461",51619,ENSG00000078967.12,UBE2D4,7,Protein processing in endoplasmic reticulum; Ubiquitin mediated proteolysis,,Antigen processing: Ubiquitination & Proteasome degradation,6,High,1
O95900,Mitochondrial mRNA pseudouridine synthase TRUB2 OS=Homo sapiens OX=9606 GN=TRUB2 PE=1 SV=1,0.001,9.372,7,2,5,2,331,36.7,8.98,3204,,2,,metabolic process,cytosol;mitochondrion;organelle lumen,catalytic activity;RNA binding,Pf01509,26995,ENSG00000167112.9,TRUB2,9,,,,0,High,1
O75064,DENN domain-containing protein 4B OS=Homo sapiens OX=9606 GN=DENND4B PE=1 SV=4,0.001,9.369,3,3,6,3,1496,163.7,7.21,2312,,3,,regulation of biological process,cytosol;Golgi;nucleus,protein binding,"Pf02141, Pf03455, Pf03456, Pf13041",9909,ENSG00000198837.9,DENND4B,1,,,RAB GEFs exchange GTP for GDP on RABs,4,High,1
O95628,CCR4-NOT transcription complex subunit 4 OS=Homo sapiens OX=9606 GN=CNOT4 PE=1 SV=3,0.001,9.362,6,3,14,3,575,63.5,7.03,5048,,3,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;protein binding;RNA binding,"Pf00076, Pf13639, Pf13893, Pf13920, Pf13923, Pf14259, Pf14570",4850,ENSG00000080802.18,CNOT4,7,RNA degradation,,TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Deadenylation of mRNA,10,High,1
P01703,Immunoglobulin lambda variable 1-40 OS=Homo sapiens OX=9606 GN=IGLV1-40 PE=1 SV=2,0.001,9.36,24,2,13,2,118,12.3,5.74,4196,1.95,2,1,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity,Pf07686,28825,ENSG00000211653.2; ENSG00000274575.2,IGLV1-40,22; CHR_HSCHR22_1_CTG3,,,FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis,26,High,1
Q49AM1,"Transcription termination factor 2, mitochondrial OS=Homo sapiens OX=9606 GN=MTERF2 PE=1 SV=2",0.001,9.35,7,2,7,2,385,44.4,8.97,1679,2.11,1,1,metabolic process;regulation of biological process,mitochondrion;organelle lumen,DNA binding,Pf02536,80298,ENSG00000120832.9,MTERFD3; MTERF2,12,,,,0,High,1
P27658,Collagen alpha-1(VIII) chain OS=Homo sapiens OX=9606 GN=COL8A1 PE=1 SV=2,0.001,9.346,8,4,14,4,744,73.3,9.61,3396,0,4,1,cell differentiation;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process,extracellular;organelle lumen,protein binding,Pf00386,1295,ENSG00000144810.15,COL8A1,3,,,Collagen degradation; Integrin cell surface interactions; Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization,8,High,1
Q9H6S0,3'-5' RNA helicase YTHDC2 OS=Homo sapiens OX=9606 GN=YTHDC2 PE=1 SV=2,0.001,9.342,2,2,4,2,1430,160.1,8.4,1662,,2,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;endoplasmic reticulum,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00271, Pf01424, Pf04146, Pf04408, Pf07717, Pf12796, Pf13637, Pf13857",64848,ENSG00000047188.15,YTHDC2,5,,,,0,High,1
P30825,High affinity cationic amino acid transporter 1 OS=Homo sapiens OX=9606 GN=SLC7A1 PE=1 SV=1,0.001,9.342,5,2,7,2,629,67.6,5.43,2347,,2,,transport,membrane,protein binding;transporter activity,"Pf00324, Pf13520, Pf13906",6541,ENSG00000139514.12,SLC7A1,13,MicroRNAs in cancer,,Amino acid transport across the plasma membrane,5,High,1
Q7Z3D4,LysM and putative peptidoglycan-binding domain-containing protein 3 OS=Homo sapiens OX=9606 GN=LYSMD3 PE=1 SV=2,0.001,9.339,8,2,6,2,306,34.5,5.97,2269,,2,,,membrane,,"Pf01476, Pf11085",116068,ENSG00000176018.12,LYSMD3,5,,,,0,High,1
Q8TB40,(Lyso)-N-acylphosphatidylethanolamine lipase OS=Homo sapiens OX=9606 GN=ABHD4 PE=2 SV=1,0.001,9.338,7,2,10,2,342,38.8,7.59,4148,,2,,metabolic process,membrane,catalytic activity,"Pf00561, Pf03403, Pf12695, Pf12697",63874,ENSG00000100439.10,ABHD4,14,,,Acyl chain remodelling of PE,5,High,1
Q15022,Polycomb protein SUZ12 OS=Homo sapiens OX=9606 GN=SUZ12 PE=1 SV=3,0.001,9.336,3,2,5,2,739,83,8.81,3075,,2,,cell organization and biogenesis;metabolic process;regulation of biological process,nucleus,catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding,Pf09733,23512,ENSG00000178691.10,SUZ12,17,,Interactome of polycomb repressive complex 2 (PRC2),PKMTs methylate histone lysines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; SUMOylation of chromatin organization proteins; Transcriptional Regulation by E2F6; Regulation of PTEN gene transcription; PRC2 methylates histones and DNA; Oxidative Stress Induced Senescence,27,High,1
Q12789,General transcription factor 3C polypeptide 1 OS=Homo sapiens OX=9606 GN=GTF3C1 PE=1 SV=4,0.001,9.319,2,3,11,3,2109,238.7,7.3,3110,,3,,metabolic process;regulation of biological process,membrane;nucleus,DNA binding;protein binding,Pf04182,2975,ENSG00000077235.17,GTF3C1,16,,,RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter,6,High,1
Q96BP3,Peptidylprolyl isomerase domain and WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=PPWD1 PE=1 SV=1,0.001,9.311,6,3,19,3,646,73.5,7.15,5234,,3,,metabolic process,nucleus;spliceosomal complex,catalytic activity;protein binding,"Pf00160, Pf00400",23398,ENSG00000113593.11,PPWD1,5,,,mRNA Splicing - Major Pathway,4,High,1
Q96EX1,Small integral membrane protein 12 OS=Homo sapiens OX=9606 GN=SMIM12 PE=1 SV=3,0.001,9.298,21,2,8,2,92,10.8,8.44,2736,,2,,,membrane,,,113444,ENSG00000163866.8,C1orf212; SMIM12,1,,,,0,High,1
Q9Y6Y0,Influenza virus NS1A-binding protein OS=Homo sapiens OX=9606 GN=IVNS1ABP PE=1 SV=3,0.001,9.297,4,3,17,3,642,71.7,5.53,7985,,3,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;nucleus;spliceosomal complex,protein binding,"Pf00651, Pf01344, Pf07646, Pf07707, Pf13415, Pf13418, Pf13854, Pf13964",10625,ENSG00000116679.15,IVNS1ABP,1,Influenza A,,,1,High,1
Q92963,GTP-binding protein Rit1 OS=Homo sapiens OX=9606 GN=RIT1 PE=1 SV=1,0.001,9.295,11,2,5,2,219,25.1,9.1,2639,,2,,regulation of biological process;response to stimulus,membrane,catalytic activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf08477",6016,ENSG00000143622.10,RIT1,1,,Ectoderm Differentiation,Signalling to p38 via RIT and RIN,7,High,1
Q9H467,CUE domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CUEDC2 PE=1 SV=1,0.001,9.293,12,3,3,3,287,32,4.81,1208,,3,,regulation of biological process,cytoplasm;cytosol;membrane;nucleus,protein binding,Pf02845,79004,ENSG00000107874.10,CUEDC2,10,,Regulation of toll-like receptor signaling pathway,,1,High,1
Q8N5Y8,Protein mono-ADP-ribosyltransferase PARP16 OS=Homo sapiens OX=9606 GN=PARP16 PE=1 SV=2,0.001,9.286,12,2,2,2,322,36.4,9.06,853,,2,,metabolic process;regulation of biological process;response to stimulus,cytosol;endoplasmic reticulum;membrane,catalytic activity;enzyme regulator activity;protein binding,Pf00644,54956,,PARP16,15,,,Nicotinamide salvaging,5,High,1
Q9H190,Syntenin-2 OS=Homo sapiens OX=9606 GN=SDCBP2 PE=1 SV=2,0.001,9.285,6,2,18,1,292,31.6,9.07,8105,,2,,cell proliferation;regulation of biological process;response to stimulus;transport,cytoplasm;membrane;nucleus,protein binding,Pf00595,27111,ENSG00000125775.14,SDCBP2,20,,,,0,High,1
Q9H4Z3,mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase OS=Homo sapiens OX=9606 GN=PCIF1 PE=1 SV=1,0.001,9.281,5,2,6,2,704,80.6,7.42,2836,,2,,regulation of biological process,cytoskeleton;nucleus,protein binding,"Pf00397, Pf12237",63935,ENSG00000100982.11,PCIF1,20,,,,0,High,1
Q96EC8,Protein YIPF6 OS=Homo sapiens OX=9606 GN=YIPF6 PE=1 SV=2,0.001,9.271,10,2,3,2,236,26.2,5.64,1415,,2,,,endoplasmic reticulum;Golgi;membrane,protein binding,Pf04893,286451,ENSG00000181704.11,YIPF6,X,,,Golgi Associated Vesicle Biogenesis,5,High,1
P09038-1,Isoform 2 of Fibroblast growth factor 2 OS=Homo sapiens OX=9606 GN=FGF2,0.001,9.27,8,2,11,2,210,22.6,10.54,4811,,2,,cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;nucleus,catalytic activity;protein binding,"Pf00167, Pf00340",2247,,FGF2,4,,MicroRNAs in cardiomyocyte hypertrophy; Cardiac Hypertrophic Response; Endochondral Ossification; Regulation of Actin Cytoskeleton,,4,High,1
Q12884,Prolyl endopeptidase FAP OS=Homo sapiens OX=9606 GN=FAP PE=1 SV=5,0.001,9.252,6,3,10,3,760,87.7,6.65,3997,,3,,cell death;cell proliferation;cellular component movement;metabolic process;regulation of biological process,cell surface;cytoplasm;extracellular;membrane,catalytic activity;protein binding,"Pf00326, Pf00930, Pf02129, Pf12695, Pf12697",2191,ENSG00000078098.13,FAP,2,,,,0,High,1
Q6PJG6,BRCA1-associated ATM activator 1 OS=Homo sapiens OX=9606 GN=BRAT1 PE=1 SV=2,0.001,9.241,5,3,5,3,821,88.1,5.27,1474,,3,,cell death;cell growth;cell proliferation;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;membrane;nucleus,protein binding,,221927,ENSG00000106009.15,BRAT1,7,,,,0,High,1
Q9UKL6,Phosphatidylcholine transfer protein OS=Homo sapiens OX=9606 GN=PCTP PE=1 SV=1,0.001,9.225,9,2,7,2,214,24.8,5.78,3413,,2,,metabolic process;transport,cytoplasm;cytosol,protein binding;transporter activity,Pf01852,58488,ENSG00000141179.13,PCTP,17,,,Synthesis of PC; Mitochondrial Fatty Acid Beta-Oxidation,7,High,1
Q9Y343,Sorting nexin-24 OS=Homo sapiens OX=9606 GN=SNX24 PE=1 SV=1,0.001,9.214,12,2,6,2,169,19.8,7.24,2756,,2,,transport,membrane,,Pf00787,28966,ENSG00000064652.10,SNX24,5,,,,0,High,1
Q15653,NF-kappa-B inhibitor beta OS=Homo sapiens OX=9606 GN=NFKBIB PE=1 SV=2,0.001,9.2,8,2,8,2,356,37.7,4.84,3497,,2,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,protein binding;signal transducer activity,"Pf00023, Pf12796, Pf13606, Pf13637, Pf13857",4793,ENSG00000282905.1; ENSG00000104825.16,NFKBIB,19; CHR_HG26_PATCH,Cytosolic DNA-sensing pathway; Epstein-Barr virus infection; Shigellosis; Herpes simplex infection; Leishmaniasis; T cell receptor signaling pathway; Influenza A; Neurotrophin signaling pathway; RIG-I-like receptor signaling pathway; NOD-like receptor signaling pathway; Measles; Th1 and Th2 cell differentiation; Toxoplasmosis; Adipocytokine signaling pathway; B cell receptor signaling pathway; Chemokine signaling pathway,IL-1 signaling pathway; TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway; Prolactin Signaling Pathway; IL17 signaling pathway; TNF alpha Signaling Pathway; Apoptosis; RIG-I-like Receptor Signaling; Chemokine signaling pathway,IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); TRAF6 mediated NF-kB activation; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; RIP-mediated NFkB activation via ZBP1; Activated TLR4 signalling; Interleukin-1 family signaling; Activation of NF-kappaB in B cells,60,High,1
Q9Y6D9,Mitotic spindle assembly checkpoint protein MAD1 OS=Homo sapiens OX=9606 GN=MAD1L1 PE=1 SV=2,0.001,9.189,3,2,6,2,718,83,5.92,2690,,2,,cell division;cell organization and biogenesis;regulation of biological process,chromosome;cytoplasm;cytoskeleton;cytosol;nucleus,protein binding,Pf05557,8379,ENSG00000002822.15,MAD1L1,7,Cell cycle; Viral carcinogenesis; Progesterone-mediated oocyte maturation,Cell Cycle,Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins,20,High,1
Q9NZ52,ADP-ribosylation factor-binding protein GGA3 OS=Homo sapiens OX=9606 GN=GGA3 PE=1 SV=1,0.001,9.179,7,3,18,3,723,78.3,5.58,4641,,3,,metabolic process;regulation of biological process;transport,endosome;Golgi;membrane,protein binding,"Pf00790, Pf02883, Pf03127",23163,ENSG00000125447.16,GGA3,17,Lysosome,,MET receptor recycling; TBC/RABGAPs; Amyloid fiber formation,11,High,1
O76009,"Keratin, type I cuticular Ha3-I OS=Homo sapiens OX=9606 GN=KRT33A PE=2 SV=2",0.001,9.175,10,4,34,3,404,45.9,4.82,11633,,4,,cell death;metabolic process,cytosol,catalytic activity;motor activity;structural molecule activity,"Pf00038, Pf01576, Pf04111, Pf04156, Pf07888, Pf12128, Pf13166, Pf13514, Pf14362",3883,ENSG00000006059.3; ENSG00000261986.1,KRT33A,17; CHR_HSCHR17_1_CTG4,,,Formation of the cornified envelope,3,High,1
Q9BQ24,Zinc finger FYVE domain-containing protein 21 OS=Homo sapiens OX=9606 GN=ZFYVE21 PE=1 SV=1,0.001,9.168,12,2,12,2,234,26.5,8.41,4382,,2,,metabolic process;transport,cytosol;endosome;membrane,catalytic activity;metal ion binding;protein binding,Pf01363,79038,ENSG00000100711.13,ZFYVE21,14,,,,0,High,1
Q147X3,N-alpha-acetyltransferase 30 OS=Homo sapiens OX=9606 GN=NAA30 PE=1 SV=1,0.001,9.164,14,3,4,3,362,39.3,5.52,1325,,3,,metabolic process,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,"Pf00583, Pf08445, Pf13508, Pf13523, Pf13527, Pf13673",122830,ENSG00000139977.13,NAA30,14,,Metapathway biotransformation,Retrograde transport at the Trans-Golgi-Network,5,High,1
O76071,Probable cytosolic iron-sulfur protein assembly protein CIAO1 OS=Homo sapiens OX=9606 GN=CIAO1 PE=1 SV=1,0.001,9.154,4,2,6,2,339,37.8,4.97,3989,,2,,cell organization and biogenesis;metabolic process;regulation of biological process,,protein binding,"Pf00400, Pf08662",9391,ENSG00000144021.2,CIAO1,2,,,Cytosolic iron-sulfur cluster assembly,2,High,1
Q9NRA8,Eukaryotic translation initiation factor 4E transporter OS=Homo sapiens OX=9606 GN=EIF4ENIF1 PE=1 SV=2,0.001,9.148,4,3,6,3,985,108.1,8.32,2022,,3,,metabolic process;regulation of biological process;transport,cytoplasm;cytosol;membrane;nucleus,protein binding;RNA binding;transporter activity,Pf10477,56478,ENSG00000184708.17,EIF4ENIF1,22,,,,0,High,1
Q9BZL1,Ubiquitin-like protein 5 OS=Homo sapiens OX=9606 GN=UBL5 PE=1 SV=1,0.001,9.145,21,2,39,2,73,8.5,8.44,17278,,2,,metabolic process,cytoplasm;nucleus,protein binding,Pf00240,59286,ENSG00000198258.10,UBL5,19,,,,0,High,1
P01742,Immunoglobulin heavy variable 1-69 OS=Homo sapiens OX=9606 GN=IGHV1-69 PE=1 SV=2,0.001,9.143,34,3,4,2,117,12.7,9.17,1352,,3,,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity,,28461,ENSG00000211973.2; ENSG00000282350.1,IGHV1-69,14; CHR_HSCHR14_3_CTG1,,,FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis,26,High,1
Q8IY47,Kelch repeat and BTB domain-containing protein 2 OS=Homo sapiens OX=9606 GN=KBTBD2 PE=1 SV=2,0.001,9.143,2,2,29,1,623,71.3,5.62,15063,,2,,metabolic process,,catalytic activity;protein binding,"Pf00651, Pf01344, Pf07646, Pf07707, Pf13964",25948,ENSG00000170852.10,KBTBD2,7,,,,0,High,1
P05423,DNA-directed RNA polymerase III subunit RPC4 OS=Homo sapiens OX=9606 GN=POLR3D PE=1 SV=2,0.001,9.123,11,3,16,3,398,44.4,6.98,6182,,3,,defense response;metabolic process;regulation of biological process;response to stimulus,cytosol;nucleus,catalytic activity;DNA binding,Pf05132,661,ENSG00000168495.12,POLR3D,8,Purine metabolism; Metabolic pathways; Cytosolic DNA-sensing pathway; Epstein-Barr virus infection; Pyrimidine metabolism; RNA polymerase,Eukaryotic Transcription Initiation,RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase III Transcription Initiation From Type 2 Promoter,19,High,1
P42679,Megakaryocyte-associated tyrosine-protein kinase OS=Homo sapiens OX=9606 GN=MATK PE=1 SV=1,0.001,9.121,4,2,26,1,507,56.4,8.81,14050,,2,,cell differentiation;cell proliferation;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00017, Pf00018, Pf00069, Pf07653, Pf07714",4145,ENSG00000007264.14,MATK,19,Neurotrophin signaling pathway,Kit receptor signaling pathway,Downregulation of ERBB2 signaling,6,High,1
Q15311,RalA-binding protein 1 OS=Homo sapiens OX=9606 GN=RALBP1 PE=1 SV=3,0.001,9.11,4,2,4,2,655,76,5.88,2581,,2,,regulation of biological process;response to stimulus;transport,cytosol;membrane,catalytic activity;enzyme regulator activity;protein binding;transporter activity,Pf00620,10928,ENSG00000017797.12,RALBP1,18,Pathways in cancer; Ras signaling pathway; Pancreatic cancer,RalA downstream regulated genes; EGF/EGFR Signaling Pathway,Rho GTPase cycle,8,High,1
Q8NDC0,MAPK-interacting and spindle-stabilizing protein-like OS=Homo sapiens OX=9606 GN=MAPK1IP1L PE=1 SV=4,0.001,9.109,7,1,1,1,245,24.3,5.62,914,,1,,,,protein binding,,93487,ENSG00000168175.14,MAPK1IP1L,14,,,,0,High,1
Q9NSK7,Protein C19orf12 OS=Homo sapiens OX=9606 GN=C19orf12 PE=1 SV=3,0.001,9.105,13,2,9,2,152,16.3,7.43,2816,,2,,cell death;cellular homeostasis;metabolic process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;membrane;mitochondrion,,,83636,ENSG00000131943.17,C19orf12,19,,,,0,High,1
Q92777,Synapsin-2 OS=Homo sapiens OX=9606 GN=SYN2 PE=2 SV=4,0.001,9.103,3,2,5,2,582,63,8.41,2565,,2,,,,,,,,,,,,,0,High,1
P57678,Gem-associated protein 4 OS=Homo sapiens OX=9606 GN=GEMIN4 PE=1 SV=2,0.001,9.101,3,2,5,2,1058,120,6.04,1484,,2,,cell organization and biogenesis;metabolic process;transport,cytoplasm;cytosol;membrane;nucleus,protein binding,,50628,ENSG00000179409.10,GEMIN4,17,RNA transport,,snRNP Assembly,4,High,1
Q15061,WD repeat-containing protein 43 OS=Homo sapiens OX=9606 GN=WDR43 PE=1 SV=3,0.001,9.096,3,2,5,2,677,74.8,5.57,1882,,2,,metabolic process;regulation of biological process,nucleus,protein binding;RNA binding,"Pf00400, Pf04003",23160,ENSG00000163811.11,WDR43,2,Ribosome biogenesis in eukaryotes,,Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol,6,High,1
P61599,N-alpha-acetyltransferase 20 OS=Homo sapiens OX=9606 GN=NAA20 PE=1 SV=1,0.001,9.09,18,2,6,2,178,20.4,5.03,2072,,2,,metabolic process,cytoplasm;cytosol;nucleus,catalytic activity,"Pf00583, Pf08445, Pf13508, Pf13527, Pf13673",51126,ENSG00000173418.11,NAA20,20,,Metapathway biotransformation,,1,High,1
Q9Y5B8,Nucleoside diphosphate kinase 7 OS=Homo sapiens OX=9606 GN=NME7 PE=1 SV=1,0.001,9.076,10,3,9,3,376,42.5,6.47,2937,,3,,metabolic process,cytosol,catalytic activity;metal ion binding;nucleotide binding;protein binding,Pf00334,29922,ENSG00000143156.13,NME7,1,Metabolic pathways; Pyrimidine metabolism; Purine metabolism,,Interconversion of nucleotide di- and triphosphates,6,High,1
P08514,Integrin alpha-IIb OS=Homo sapiens OX=9606 GN=ITGA2B PE=1 SV=3,0.001,9.073,4,3,6,3,1039,113.3,5.38,1816,,3,,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cell surface;membrane,metal ion binding;protein binding,"Pf00357, Pf01839, Pf08441, Pf13517",3674,ENSG00000005961.17,ITGA2B,17,PI3K-Akt signaling pathway; Pathways in cancer; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Platelet activation; Small cell lung cancer; Hematopoietic cell lineage; Focal adhesion; Rap1 signaling pathway; Hypertrophic cardiomyopathy (HCM); Dilated cardiomyopathy; ECM-receptor interaction; Regulation of actin cytoskeleton,Integrin-mediated Cell Adhesion; Arrhythmogenic Right Ventricular Cardiomyopathy; Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,Integrin cell surface interactions; Signaling by BRAF and RAF fusions; Signal transduction by L1; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; MAP2K and MAPK activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; p130Cas linkage to MAPK signaling for integrins; Platelet degranulation ; ECM proteoglycans; Paradoxical activation of RAF signaling by kinase inactive BRAF; Interleukin-20 family signaling,54,High,1
Q5JTJ3,Cytochrome c oxidase assembly factor 6 homolog OS=Homo sapiens OX=9606 GN=COA6 PE=1 SV=1,0.001,9.059,11,1,26,1,125,14.1,8.25,11262,,1,,cell organization and biogenesis;metabolic process,membrane;mitochondrion,catalytic activity;metal ion binding;protein binding;RNA binding;transporter activity,Pf02297,388753,ENSG00000168275.14,COA6,1,,,Mitochondrial protein import; Metabolism of proteins,2,High,1
Q9Y4I1,Unconventional myosin-Va OS=Homo sapiens OX=9606 GN=MYO5A PE=1 SV=2,0.001,9.058,3,4,18,4,1855,215.3,8.48,5097,,4,,cell communication;cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;endosome;extracellular;Golgi;membrane;vacuole,catalytic activity;metal ion binding;motor activity;nucleotide binding;protein binding;RNA binding,"Pf00063, Pf00612, Pf00769, Pf01442, Pf01576, Pf01843, Pf02463, Pf04111, Pf04156, Pf05262, Pf05557, Pf06160, Pf07888, Pf07926, Pf09726, Pf09731, Pf10174, Pf12128, Pf12718, Pf13851, Pf14992, Pf15035, Pf15070",4644,ENSG00000197535.14,MYO5A,15,,,Translocation of GLUT4 to the plasma membrane; Regulation of actin dynamics for phagocytic cup formation; Insulin processing,10,High,1
O75676,Ribosomal protein S6 kinase alpha-4 OS=Homo sapiens OX=9606 GN=RPS6KA4 PE=1 SV=1,0.001,9.054,5,3,8,2,772,85.6,8.28,3616,,3,,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf00433, Pf01163, Pf01636, Pf07714, Pf14531",8986,ENSG00000162302.12,RPS6KA4,11,TNF signaling pathway; MAPK signaling pathway,Angiopoietin Like Protein 8 Regulatory Pathway; Insulin Signaling; Interferon type I signaling pathways,Recycling pathway of L1,9,High,1
Q9NSI6,Bromodomain and WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=BRWD1 PE=1 SV=4,0.001,9.053,1,2,2,1,2320,262.8,8.46,1078,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,protein binding,"Pf00400, Pf00439",54014,ENSG00000185658.13,BRWD1,21,,,Interleukin-7 signaling; Chromatin modifying enzymes,6,High,1
P55008,Allograft inflammatory factor 1 OS=Homo sapiens OX=9606 GN=AIF1 PE=1 SV=1,0.001,9.048,14,1,5,1,147,16.7,6.24,2877,,1,,cell communication;cell organization and biogenesis;defense response;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,metal ion binding;protein binding,Pf13499,199,ENSG00000234836.7; ENSG00000235985.7; ENSG00000204472.12; ENSG00000206428.9; ENSG00000235588.8; ENSG00000237727.7,AIF1,6; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_COX_CTG1,,Spinal Cord Injury,,1,High,1
O43314,Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 OS=Homo sapiens OX=9606 GN=PPIP5K2 PE=1 SV=3,0.001,9.039,3,3,20,3,1243,140.3,8.22,7739,,3,,metabolic process,cytoplasm;cytosol,catalytic activity;nucleotide binding,"Pf00328, Pf08443",23262,ENSG00000145725.19,PPIP5K2,5,Phosphatidylinositol signaling system,,Synthesis of pyrophosphates in the cytosol,4,High,1
Q96AA3,Protein RFT1 homolog OS=Homo sapiens OX=9606 GN=RFT1 PE=1 SV=1,0.001,9.028,5,3,7,3,541,60.3,8.85,2243,,3,,cell organization and biogenesis;transport,membrane,transporter activity,Pf04506,91869,ENSG00000163933.9,RFT1,3,,,"Defective RFT1 causes RFT1-CDG (CDG-1n); Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein",8,High,1
A8MSI8,LYR motif-containing protein 9 OS=Homo sapiens OX=9606 GN=LYRM9 PE=3 SV=2,0.001,9.022,26,2,17,2,78,9.4,9.66,7313,,2,,,,,"Pf05347, Pf13232",201229,ENSG00000232859.9,LYRM9,17,,,,0,High,1
P80188,Neutrophil gelatinase-associated lipocalin OS=Homo sapiens OX=9606 GN=LCN2 PE=1 SV=2,0.001,9.001,8,1,2,1,198,22.6,8.91,934,,1,,cell communication;cell death;cell organization and biogenesis;cellular homeostasis;defense response;regulation of biological process;response to stimulus;transport,cytosol;extracellular;organelle lumen,metal ion binding;protein binding;transporter activity,Pf00061,3934,ENSG00000148346.11,LCN2,9,,,Interleukin-4 and 13 signaling; Neutrophil degranulation; Iron uptake and transport; Metal sequestration by antimicrobial proteins,10,High,1
P06454,Prothymosin alpha OS=Homo sapiens OX=9606 GN=PTMA PE=1 SV=2,0.001,8.999,13,1,10,1,111,12.2,3.78,5591,,1,,cell organization and biogenesis;metabolic process,cytosol;nucleus,protein binding,,5757,ENSG00000187514.16,PTMA,2,Epstein-Barr virus infection,,,1,High,1
Q5TZA2,Rootletin OS=Homo sapiens OX=9606 GN=CROCC PE=1 SV=1,0.001,8.992,2,3,4,3,2017,228.4,5.5,1197,,3,,cell organization and biogenesis;regulation of biological process,cytoplasm;cytoskeleton;cytosol;membrane,protein binding;structural molecule activity,"Pf12128, Pf15035",9696,,CROCC,1,,,,0,High,1
Q96ES6,Major facilitator superfamily domain-containing protein 3 OS=Homo sapiens OX=9606 GN=MFSD3 PE=2 SV=1,0.001,8.991,6,2,6,2,412,42.7,9.17,2630,,2,,transport,membrane,transporter activity,,113655,ENSG00000167700.8,MFSD3,8,,,,0,High,1
Q96A57,Transmembrane protein 230 OS=Homo sapiens OX=9606 GN=TMEM230 PE=1 SV=1,0.001,8.98,19,2,23,2,120,13.2,9.31,9358,,2,,transport,endoplasmic reticulum;endosome;Golgi;membrane;vacuole,,Pf05915,29058,ENSG00000089063.14,TMEM230,20,,,,0,High,1
Q6PH85,DCN1-like protein 2 OS=Homo sapiens OX=9606 GN=DCUN1D2 PE=1 SV=1,0.001,8.966,5,1,7,1,259,30.2,6,,16.4,,1,metabolic process;regulation of biological process,,protein binding,"Pf03556, Pf14555",55208,ENSG00000150401.14,DCUN1D2,13,,,Neddylation,3,High,1
Q6Y1H2,Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 OS=Homo sapiens OX=9606 GN=HACD2 PE=1 SV=1,0.001,8.954,9,2,5,2,254,28.4,9.55,1873,,2,,metabolic process,endoplasmic reticulum;membrane,catalytic activity;protein binding,Pf04387,201562,ENSG00000206527.9,PTPLB; HACD2,3,Biosynthesis of unsaturated fatty acids; Fatty acid metabolism; Fatty acid elongation,,Synthesis of very long-chain fatty acyl-CoAs,8,High,1
Q6UB35,"Monofunctional C1-tetrahydrofolate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=MTHFD1L PE=1 SV=1",0.001,8.947,4,2,4,1,978,105.7,8.06,1456,,2,,metabolic process,membrane;mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding,"Pf00763, Pf01268, Pf02882",25902,ENSG00000120254.15,MTHFD1L,6,Metabolic pathways; One carbon pool by folate,One Carbon Metabolism; Trans-sulfuration and one carbon metabolism,Metabolism of folate and pterines,8,High,1
O95070,Protein YIF1A OS=Homo sapiens OX=9606 GN=YIF1A PE=1 SV=2,0.001,8.922,6,1,6,1,293,32,8.95,3152,,1,,transport,endoplasmic reticulum;Golgi;membrane,protein binding,Pf03878,10897,ENSG00000174851.15,YIF1A,11,,,XBP1(S) activates chaperone genes,4,High,1
Q9NVH0,Exonuclease 3'-5' domain-containing protein 2 OS=Homo sapiens OX=9606 GN=EXD2 PE=1 SV=2,0.001,8.921,4,2,12,2,621,70.3,8.32,6313,,2,,metabolic process;response to stimulus,cytoplasm;nucleus,catalytic activity;protein binding,Pf01612,55218,ENSG00000081177.18,EXD2,14,,,,0,High,1
Q8WXX5,DnaJ homolog subfamily C member 9 OS=Homo sapiens OX=9606 GN=DNAJC9 PE=1 SV=1,0.001,8.919,9,2,6,2,260,29.9,5.73,2202,,2,,regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,protein binding,Pf00226,23234,ENSG00000213551.4,DNAJC9,10,,,,0,High,1
Q68DQ2,Very large A-kinase anchor protein OS=Homo sapiens OX=9606 GN=CRYBG3 PE=1 SV=3,0.001,8.917,1,3,7,3,2970,330.4,5.2,2368,0,3,1,,,protein binding,"Pf00030, Pf00652, Pf14200",131544,ENSG00000080200.9,CRYBG3,3,,,,0,High,1
Q8IWW6,Rho GTPase-activating protein 12 OS=Homo sapiens OX=9606 GN=ARHGAP12 PE=1 SV=1,0.001,8.916,4,3,7,3,846,96.2,7.61,1781,0,3,1,cell organization and biogenesis;regulation of biological process;response to stimulus,cytosol,enzyme regulator activity;protein binding,"Pf00018, Pf00169, Pf00397, Pf00620, Pf14604",94134,ENSG00000165322.17,ARHGAP12,10,,,Rho GTPase cycle,3,High,1
Q6ZSS7,Major facilitator superfamily domain-containing protein 6 OS=Homo sapiens OX=9606 GN=MFSD6 PE=1 SV=2,0.001,8.887,5,3,6,3,791,88,5.53,1992,,3,,transport,membrane,,"Pf01306, Pf07690, Pf12832",54842,ENSG00000151690.14,MFSD6,2,,,,0,High,1
Q5T200,Zinc finger CCCH domain-containing protein 13 OS=Homo sapiens OX=9606 GN=ZC3H13 PE=1 SV=1,0.001,8.876,2,3,4,3,1668,196.5,9.42,1491,,3,,,nucleus,metal ion binding;protein binding;RNA binding,Pf00642,23091,ENSG00000123200.16,ZC3H13,13,,,,0,High,1
Q9H5X1,Cytosolic iron-sulfur assembly component 2A OS=Homo sapiens OX=9606 GN=CIAO2A PE=1 SV=1,0.001,8.87,14,2,2,2,160,18.3,4.88,1058,,2,,,cytoplasm;cytosol;nucleus,metal ion binding;protein binding,,84191,ENSG00000166797.10,FAM96A,15,,,,0,High,1
Q9HCM4,Band 4.1-like protein 5 OS=Homo sapiens OX=9606 GN=EPB41L5 PE=1 SV=3,0.001,8.853,3,2,12,2,733,81.8,6.58,5644,,2,,cell growth;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane,protein binding;structural molecule activity,"Pf00373, Pf08736, Pf09379, Pf09380",57669,ENSG00000115109.13,EPB41L5,2,,Endoderm Differentiation; Mesodermal Commitment Pathway,Neurexins and neuroligins,5,High,1
Q92686,Neurogranin OS=Homo sapiens OX=9606 GN=NRGN PE=1 SV=1,0.001,8.845,19,2,12,2,78,7.6,7.87,4618,,2,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;membrane;nucleus,catalytic activity;protein binding,Pf00612,4900,ENSG00000154146.12,NRGN,11,,,,0,High,1
Q5JS54,Proteasome assembly chaperone 4 OS=Homo sapiens OX=9606 GN=PSMG4 PE=1 SV=2,0.001,8.833,30,2,10,2,123,13.8,6.52,2194,,2,,cell organization and biogenesis,,,,389362,ENSG00000180822.11,PSMG4,6,,,,0,High,1
Q86XE3,"Calcium uptake protein 3, mitochondrial OS=Homo sapiens OX=9606 GN=MICU3 PE=1 SV=1",0.001,8.828,6,2,3,2,530,60.7,8.21,949,,2,,transport,membrane;mitochondrion,metal ion binding,"Pf00036, Pf13833",286097,ENSG00000155970.11,EFHA2; MICU3,8,,,Processing of SMDT1,3,High,1
O60508,Pre-mRNA-processing factor 17 OS=Homo sapiens OX=9606 GN=CDC40 PE=1 SV=1,0.001,8.824,4,3,12,3,579,65.5,7.06,3560,,3,,cell organization and biogenesis;metabolic process;transport,cytoplasm;nucleus;spliceosomal complex,protein binding;RNA binding,Pf00400,51362,ENSG00000168438.14,CDC40,6,Spliceosome,mRNA Processing,Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; mRNA Splicing - Major Pathway,13,High,1
P12724,Eosinophil cationic protein OS=Homo sapiens OX=9606 GN=RNASE3 PE=1 SV=2,0.001,8.822,15,2,56,2,160,18.4,10.02,13929,,2,,defense response;metabolic process;response to stimulus;transport,extracellular;organelle lumen,catalytic activity,Pf00074,6037,ENSG00000169397.3,RNASE3,14,Asthma,,Antimicrobial peptides; Neutrophil degranulation,5,High,1
Q15545,Transcription initiation factor TFIID subunit 7 OS=Homo sapiens OX=9606 GN=TAF7 PE=1 SV=1,0.001,8.821,9,3,5,3,349,40.2,5.2,1649,,3,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;Golgi;nucleus,DNA binding;protein binding,Pf04658,6879,ENSG00000178913.7,TAF7,5,Basal transcription factors,Eukaryotic Transcription Initiation,RNA Polymerase II Transcription Initiation; HIV Transcription Initiation; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; RNA Polymerase II Promoter Escape,21,High,1
O95461,LARGE xylosyl- and glucuronyltransferase 1 OS=Homo sapiens OX=9606 GN=LARGE1 PE=1 SV=1,0.001,8.812,4,3,8,3,756,88,7.84,2886,,3,,cellular homeostasis;metabolic process,Golgi;membrane,catalytic activity;metal ion binding;protein binding,"Pf01501, Pf13896",9215,ENSG00000133424.20,LARGE; LARGE1,22,,,Defective LARGE causes MDDGA6 and MDDGB6; O-linked glycosylation,7,High,1
Q8N697,Solute carrier family 15 member 4 OS=Homo sapiens OX=9606 GN=SLC15A4 PE=1 SV=1,0.001,8.808,2,1,2,1,577,62,9,1260,,1,,transport,membrane,protein binding;transporter activity,Pf00854,121260,ENSG00000139370.11,SLC15A4,12,,,Proton/oligopeptide cotransporters; Neutrophil degranulation,7,High,1
Q9NQ92,Coordinator of PRMT5 and differentiation stimulator OS=Homo sapiens OX=9606 GN=COPRS PE=1 SV=3,0.001,8.801,15,2,6,2,184,20.1,4.18,3079,,2,,cell organization and biogenesis;metabolic process;regulation of biological process,cytosol;membrane;nucleus,protein binding,Pf15340,55352,ENSG00000172301.10,COPRS,17,,,RMTs methylate histone arginines,3,High,1
Q9NWB6,Arginine and glutamate-rich protein 1 OS=Homo sapiens OX=9606 GN=ARGLU1 PE=1 SV=1,0.001,8.786,6,2,18,2,273,33.2,10.35,8232,,2,,metabolic process;regulation of biological process,mitochondrion;nucleus,protein binding,Pf15346,55082,ENSG00000134884.13,ARGLU1,13,,,,0,High,1
Q9NRY6,Phospholipid scramblase 3 OS=Homo sapiens OX=9606 GN=PLSCR3 PE=1 SV=2,0.001,8.785,9,3,8,3,295,31.6,6.65,2826,,3,,cell death;cell organization and biogenesis;response to stimulus,membrane;mitochondrion,metal ion binding;protein binding;transporter activity,Pf03803,57048,ENSG00000187838.16; ENSG00000284009.1,PLSCR3,17; CHR_HG2046_PATCH,,,,0,High,1
P46087,Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase OS=Homo sapiens OX=9606 GN=NOP2 PE=1 SV=2,0.001,8.781,3,2,5,2,812,89.2,9.23,2180,0,2,1,cell organization and biogenesis;metabolic process;regulation of biological process,nucleus,catalytic activity;protein binding;RNA binding,"Pf01189, Pf12847",4839,ENSG00000111641.11,NOP2,12,,Imatinib and Chronic Myeloid Leukemia,TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation; rRNA modification in the nucleus and cytosol,10,High,1
Q53HC0,Coiled-coil domain-containing protein 92 OS=Homo sapiens OX=9606 GN=CCDC92 PE=1 SV=2,0.001,8.776,11,3,11,3,331,36.9,8.9,4080,,3,,,cytoplasm;cytoskeleton,protein binding,Pf14916,80212,ENSG00000275035.2; ENSG00000119242.8,CCDC92,12; CHR_HSCHR12_6_CTG2_1,,,,0,High,1
Q12841,Follistatin-related protein 1 OS=Homo sapiens OX=9606 GN=FSTL1 PE=1 SV=1,0.001,8.756,5,2,28,2,308,35,5.52,10945,,2,,metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane;organelle lumen,metal ion binding;protein binding;transporter activity,"Pf00050, Pf03137, Pf07648, Pf13499",11167,ENSG00000163430.11,FSTL1,3,,,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Signaling by BMP,7,High,1
Q99836,Myeloid differentiation primary response protein MyD88 OS=Homo sapiens OX=9606 GN=MYD88 PE=1 SV=1,0.001,8.755,11,4,6,4,296,33.2,6.15,2057,,4,,cell death;defense response;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,protein binding,"Pf00531, Pf01582, Pf13676",4615,,MYD88,3,Measles; NOD-like receptor signaling pathway; African trypanosomiasis; Pertussis; Toll-like receptor signaling pathway; Hepatitis B; Toxoplasmosis; Herpes simplex infection; Leishmaniasis; Malaria; Influenza A; NF-kappa B signaling pathway; Salmonella infection; Chagas disease (American trypanosomiasis); Legionellosis; Tuberculosis,Regulation of toll-like receptor signaling pathway; IL-1 signaling pathway; AGE/RAGE pathway; Structural Pathway of Interleukin 1 (IL-1); IL1 and megakaryocytes in obesity; TLR4 Signaling and Tolerance; Toll-like Receptor Signaling; Simplified Depiction of MYD88 Distinct Input-Output Pathway; Toll-like receptor signaling pathway,"TRAF6 mediated NF-kB activation; TRAF6 mediated IRF7 activation; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; RIP-mediated NFkB activation via ZBP1; Activated TLR4 signalling; Interleukin-1 family signaling; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling; p75NTR recruits signalling complexes; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; IRAK4 deficiency (TLR2/4); ER-Phagosome pathway; MyD88 deficiency (TLR5); IRAK4 deficiency (TLR5); DEx/H-box helicases activate type I IFN and inflammatory cytokines production ; MyD88 deficiency (TLR2/4); Signalling by NGF",77,High,1
Q01968,Inositol polyphosphate 5-phosphatase OCRL OS=Homo sapiens OX=9606 GN=OCRL PE=1 SV=3,0.001,8.754,2,2,4,2,901,104.1,6.55,1951,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endosome;Golgi;membrane;nucleus,catalytic activity;enzyme regulator activity;protein binding,"Pf00620, Pf03372",4952,ENSG00000122126.15,OCRL,X,Phosphatidylinositol signaling system; Metabolic pathways; Inositol phosphate metabolism,,"Synthesis of PIPs at the Golgi membrane; Synthesis of IP3 and IP4 in the cytosol; Synthesis of IP2, IP, and Ins in the cytosol; Clathrin-mediated endocytosis; Rho GTPase cycle; Synthesis of PIPs at the plasma membrane; Golgi Associated Vesicle Biogenesis",21,High,1
Q9BTD8,RNA-binding protein 42 OS=Homo sapiens OX=9606 GN=RBM42 PE=1 SV=1,0.001,8.754,4,2,6,2,480,50.4,9.63,2611,,2,,regulation of biological process,cytoplasm;nucleus,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",79171,ENSG00000126254.11,RBM42,19,,,,0,High,1
P23443,Ribosomal protein S6 kinase beta-1 OS=Homo sapiens OX=9606 GN=RPS6KB1 PE=1 SV=2,0.001,8.75,7,3,8,3,525,59.1,6.65,2178,,3,,cell death;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus,cell surface;cytoplasm;cytosol;membrane;mitochondrion;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf00433, Pf07714, Pf14531",6198,ENSG00000108443.13,RPS6KB1,17,Breast cancer; TGF-beta signaling pathway; Fc gamma R-mediated phagocytosis; Proteoglycans in cancer; HIF-1 signaling pathway; Longevity regulating pathway; AMPK signaling pathway; ErbB signaling pathway; Endocrine resistance; Acute myeloid leukemia; mTOR signaling pathway; Insulin signaling pathway; Choline metabolism in cancer; Longevity regulating pathway - multiple species; PI3K-Akt signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin resistance,IL-5 Signaling Pathway; AMP-activated Protein Kinase (AMPK) Signaling; Target Of Rapamycin (TOR) Signaling; Human Thyroid Stimulating Hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle Stimulating Hormone (FSH) signaling pathway; Prolactin Signaling Pathway; Interleukin-11 Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Kit receptor signaling pathway; IL-6 signaling pathway; BDNF-TrkB Signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; IL-4 Signaling Pathway; EGF/EGFR Signaling Pathway; Cytoplasmic Ribosomal Proteins; Insulin Signaling; IL-2 Signaling Pathway; G13 Signaling Pathway; Interferon type I signaling pathways; ErbB Signaling Pathway,mTORC1-mediated signalling,45,High,1
Q9UH03,Neuronal-specific septin-3 OS=Homo sapiens OX=9606 GN=SEPTIN3 PE=1 SV=3,0.001,8.748,6,2,31,1,358,40.7,7.2,15327,,2,,cell division,cytoplasm;cytoskeleton,catalytic activity;nucleotide binding;protein binding,"Pf00735, Pf01926, Pf03193",55964,ENSG00000100167.19,SEPT3,22,Bacterial invasion of epithelial cells,,,1,High,1
Q9Y5Z7,Host cell factor 2 OS=Homo sapiens OX=9606 GN=HCFC2 PE=1 SV=1,0.001,8.73,2,2,3,1,792,86.7,8.48,1702,,2,,regulation of biological process,cytoplasm;cytosol;membrane;nucleus,protein binding,"Pf00041, Pf01344, Pf13415, Pf13418, Pf13854",29915,ENSG00000111727.11,HCFC2,12,Herpes simplex infection,,,1,High,1
O43299,AP-5 complex subunit zeta-1 OS=Homo sapiens OX=9606 GN=AP5Z1 PE=1 SV=2,0.001,8.723,6,3,5,3,807,88.5,7.01,1286,,3,,metabolic process;response to stimulus;transport,cytoplasm;nucleus,protein binding,Pf14764,9907,ENSG00000242802.6,AP5Z1,7,,,,0,High,1
Q9BPX6,"Calcium uptake protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=MICU1 PE=1 SV=1",0.001,8.723,5,2,4,2,476,54.3,8.41,2340,,2,,cell organization and biogenesis;cellular homeostasis;defense response;response to stimulus;transport,membrane;mitochondrion,metal ion binding;protein binding,Pf13202,10367,ENSG00000107745.17,MICU1,10,,,Processing of SMDT1,3,High,1
O75312,Zinc finger protein ZPR1 OS=Homo sapiens OX=9606 GN=ZPR1 PE=1 SV=1,0.001,8.722,8,3,6,3,459,50.9,4.73,2144,,3,,cell death;cell differentiation;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,metal ion binding;protein binding,Pf03367,8882,ENSG00000109917.10,ZNF259; ZPR1,11,,,,0,High,1
Q9P1F3,Costars family protein ABRACL OS=Homo sapiens OX=9606 GN=ABRACL PE=1 SV=1,0.001,8.72,20,1,27,1,81,9.1,6.29,8069,,1,,,,,Pf14705,58527,ENSG00000146386.7,ABRACL,6,,,,0,High,1
Q6NYC8,Phostensin OS=Homo sapiens OX=9606 GN=PPP1R18 PE=1 SV=1,0.001,8.717,10,2,3,2,613,67.9,5.4,1017,,2,,,cytoplasm;cytoskeleton,protein binding,"Pf13914, Pf13916",170954,ENSG00000229998.8; ENSG00000225060.8; ENSG00000230341.8; ENSG00000146112.11; ENSG00000234000.8,PPP1R18,6; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_APD_CTG1; CHR_HSCHR6_MHC_DBB_CTG1,,TYROBP Causal Network,,1,High,1
Q99519,Sialidase-1 OS=Homo sapiens OX=9606 GN=NEU1 PE=1 SV=1,0.001,8.717,5,2,9,2,415,45.4,5.88,3876,,2,,metabolic process;transport,extracellular;membrane;organelle lumen;vacuole,catalytic activity;protein binding,"Pf13088, Pf13859",4758,ENSG00000234343.6; ENSG00000227129.6; ENSG00000223957.6; ENSG00000234846.7; ENSG00000184494.8; ENSG00000227315.7; ENSG00000204386.10; ENSG00000228691.6,NEU1,6; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_APD_CTG1,Lysosome; Other glycan degradation; Sphingolipid metabolism,Regulation of toll-like receptor signaling pathway,Sialic acid metabolism; Neutrophil degranulation; Defective NEU1 causes sialidosis; Glycosphingolipid metabolism,21,High,1
Q5SY16,Polynucleotide 5'-hydroxyl-kinase NOL9 OS=Homo sapiens OX=9606 GN=NOL9 PE=1 SV=1,0.001,8.7,7,3,3,3,702,79.3,9.13,972,,3,,metabolic process,cytoskeleton;membrane;nucleus,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding;RNA binding,"Pf03205, Pf06807",79707,ENSG00000162408.10,NOL9,1,,,Major pathway of rRNA processing in the nucleolus and cytosol,4,High,1
Q9HBM0,Vezatin OS=Homo sapiens OX=9606 GN=VEZT PE=1 SV=3,0.001,8.693,2,1,4,1,779,88.6,5.2,2057,,1,,,cytosol;membrane;nucleus,protein binding,"Pf04290, Pf12632",55591,ENSG00000028203.17,VEZT,12,,,,0,High,1
Q15034,Probable E3 ubiquitin-protein ligase HERC3 OS=Homo sapiens OX=9606 GN=HERC3 PE=1 SV=1,0.001,8.688,2,2,4,2,1050,117.1,6.28,1632,,2,,metabolic process,cytoplasm;cytosol,catalytic activity,"Pf00415, Pf00632, Pf13540",8916,ENSG00000138641.15,HERC3,4,Ubiquitin mediated proteolysis,,Antigen processing: Ubiquitination & Proteasome degradation,5,High,1
P98164,Low-density lipoprotein receptor-related protein 2 OS=Homo sapiens OX=9606 GN=LRP2 PE=1 SV=3,0.001,8.687,1,4,21,4,4655,521.6,5.08,6812,,4,,cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;transport,endoplasmic reticulum;endosome;Golgi;membrane;organelle lumen;vacuole,metal ion binding;protein binding;receptor activity;transporter activity,"Pf00057, Pf00058, Pf07645, Pf12662, Pf14670",4036,ENSG00000081479.12,LRP2,2,Hedgehog signaling pathway; Thyroid hormone synthesis,Vitamin B12 Metabolism,Signaling by GPCR; Cargo recognition for clathrin-mediated endocytosis; Vitamin D (calciferol) metabolism; Retinoid metabolism and transport,17,High,1
A5D8V6,Vacuolar protein sorting-associated protein 37C OS=Homo sapiens OX=9606 GN=VPS37C PE=1 SV=2,0.001,8.685,6,2,15,2,355,38.6,5.21,4841,,2,,cell communication;cell organization and biogenesis;metabolic process;response to stimulus;transport,endosome;membrane,catalytic activity;motor activity;protein binding,"Pf01576, Pf05622, Pf07200",55048,ENSG00000167987.10,VPS37C,11,Endocytosis,,Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); Membrane binding and targetting of GAG proteins,13,High,1
Q9BZQ6,ER degradation-enhancing alpha-mannosidase-like protein 3 OS=Homo sapiens OX=9606 GN=EDEM3 PE=1 SV=2,0.001,8.676,3,2,7,2,932,104.6,4.93,3099,,2,,metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;membrane;organelle lumen,catalytic activity;metal ion binding,"Pf01532, Pf02225",80267,ENSG00000116406.18,EDEM3,1,Protein processing in endoplasmic reticulum,,ER Quality Control Compartment (ERQC),7,High,1
Q8N3R3,"T-cell activation inhibitor, mitochondrial OS=Homo sapiens OX=9606 GN=TCAIM PE=2 SV=2",0.001,8.673,5,2,3,2,496,57.9,8.69,1230,,2,,,mitochondrion,,"Pf14687, Pf14688",285343,ENSG00000179152.19,TCAIM,3,,,,0,High,1
Q8NBI5,Solute carrier family 43 member 3 OS=Homo sapiens OX=9606 GN=SLC43A3 PE=1 SV=2,0.001,8.668,3,2,7,2,491,54.5,8.53,3095,,2,,transport,membrane,,,29015,ENSG00000134802.17,SLC43A3,11,,,,0,High,1
Q9H098,Protein FAM107B OS=Homo sapiens OX=9606 GN=FAM107B PE=1 SV=1,0.001,8.667,26,3,10,3,131,15.5,8.29,3743,,3,,,,,Pf06625,83641,ENSG00000065809.13,FAM107B,10,,,,0,High,1
A0A0B4J1U7,Immunoglobulin heavy variable 6-1 OS=Homo sapiens OX=9606 GN=IGHV6-1 PE=3 SV=1,0.001,8.665,12,2,49,2,121,13.5,9.2,22800,,2,,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,protein binding,,28385,ENSG00000282745.1; ENSG00000211933.2,IGHV6-1,14; CHR_HSCHR14_3_CTG1,,,,0,High,1
P01701,Immunoglobulin lambda variable 1-51 OS=Homo sapiens OX=9606 GN=IGLV1-51 PE=1 SV=2,0.001,8.65,20,2,26,2,117,12.2,7.03,11641,,2,,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity,,28820,ENSG00000211644.3,IGLV1-51,22,,,FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis,26,High,1
Q8IUH3,RNA-binding protein 45 OS=Homo sapiens OX=9606 GN=RBM45 PE=1 SV=1,0.001,8.649,4,2,3,2,476,53.5,7.17,1433,,2,,cell differentiation;development,cytoplasm;nucleus,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",129831,ENSG00000155636.14,RBM45,2,,,,0,High,1
Q96QD8,Sodium-coupled neutral amino acid transporter 2 OS=Homo sapiens OX=9606 GN=SLC38A2 PE=1 SV=2,0.001,8.649,7,2,4,2,506,56,8,1247,,2,,cell communication;response to stimulus;transport,membrane,protein binding;transporter activity,Pf01490,54407,ENSG00000134294.13,SLC38A2,12,GABAergic synapse; Protein digestion and absorption; Glutamatergic synapse,Endochondral Ossification,Amino acid transport across the plasma membrane; Glutamate Neurotransmitter Release Cycle,12,High,1
O95602,DNA-directed RNA polymerase I subunit RPA1 OS=Homo sapiens OX=9606 GN=POLR1A PE=1 SV=2,0.001,8.645,2,3,26,3,1720,194.7,7.03,8486,,3,,metabolic process;regulation of biological process,nucleus,catalytic activity;DNA binding;metal ion binding;protein binding,"Pf00623, Pf04983, Pf04997, Pf04998, Pf05000",25885,ENSG00000068654.15,POLR1A,2,Metabolic pathways; Purine metabolism; Pyrimidine metabolism; RNA polymerase,Eukaryotic Transcription Initiation,RNA Polymerase I Chain Elongation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Termination; RNA Polymerase I Promoter Escape; B-WICH complex positively regulates rRNA expression; RNA Polymerase I Transcription Initiation,17,High,1
Q9BZ23,"Pantothenate kinase 2, mitochondrial OS=Homo sapiens OX=9606 GN=PANK2 PE=1 SV=3",0.001,8.616,8,3,6,3,570,62.6,9.28,2452,,3,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;mitochondrion,catalytic activity;nucleotide binding,Pf03630,80025,ENSG00000125779.21,PANK2,20,Metabolic pathways; Pantothenate and CoA biosynthesis,,Coenzyme A biosynthesis,7,High,1
Q5VST6,Alpha/beta hydrolase domain-containing protein 17B OS=Homo sapiens OX=9606 GN=ABHD17B PE=1 SV=1,0.001,8.613,15,2,3,2,288,32.2,6.29,1264,,2,,metabolic process;regulation of biological process,extracellular;membrane,catalytic activity,"Pf00326, Pf01738, Pf02230, Pf03959, Pf05728, Pf12695, Pf12697",51104,ENSG00000107362.13,ABHD17B; FAM108B1,9,,,,0,High,1
Q9UKM7,"Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase OS=Homo sapiens OX=9606 GN=MAN1B1 PE=1 SV=2",0.001,8.601,4,2,4,2,699,79.5,7.72,1669,,2,,metabolic process,endoplasmic reticulum;Golgi;membrane,catalytic activity;metal ion binding,Pf01532,11253,ENSG00000177239.14,MAN1B1,9,Protein processing in endoplasmic reticulum; Metabolic pathways; N-Glycan biosynthesis,,ER Quality Control Compartment (ERQC); Defective MAN1B1 causes MRT15,13,High,1
O00258,Tail-anchored protein insertion receptor WRB OS=Homo sapiens OX=9606 GN=WRB PE=1 SV=2,0.001,8.59,11,2,9,2,174,19.8,9.67,4450,,2,,,endoplasmic reticulum;membrane;nucleus,,"Pf04420, Pf07798",7485,ENSG00000182093.14,WRB,21,,,,0,High,1
Q9UIS9,Methyl-CpG-binding domain protein 1 OS=Homo sapiens OX=9606 GN=MBD1 PE=1 SV=2,0.001,8.581,6,2,3,2,605,66.6,9.04,1185,,2,,cell differentiation;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;nucleus,DNA binding;metal ion binding;nucleotide binding;protein binding,"Pf01429, Pf02008",4152,ENSG00000141644.17,MBD1,18,,Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,,1,High,1
Q8IZ69,tRNA (uracil-5-)-methyltransferase homolog A OS=Homo sapiens OX=9606 GN=TRMT2A PE=1 SV=2,0.001,8.578,4,2,8,2,625,68.7,7.94,3608,,2,,metabolic process,,catalytic activity;RNA binding,"Pf00076, Pf01135, Pf01170, Pf01209, Pf02475, Pf03602, Pf05175, Pf05958, Pf06325, Pf08241, Pf09445, Pf12847, Pf13649, Pf13659, Pf13847, Pf13893, Pf14259",27037,ENSG00000099899.14,TRMT2A,22,,,,0,High,1
P17096-2,Isoform HMG-Y of High mobility group protein HMG-I/HMG-Y OS=Homo sapiens OX=9606 GN=HMGA1,0.001,8.576,15,2,9,1,96,10.7,10.32,493,15.6,1,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,chromosome;cytosol;nucleus,catalytic activity;DNA binding;protein binding,,3159,ENSG00000137309.19,HMGA1,6,,Adipogenesis; Preimplantation Embryo; Senescence and Autophagy in Cancer,,3,High,1
Q96EB1,Elongator complex protein 4 OS=Homo sapiens OX=9606 GN=ELP4 PE=1 SV=2,0.001,8.569,7,3,9,3,424,46.6,8.51,3220,,3,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;nucleus,catalytic activity;enzyme regulator activity;protein binding,Pf05625,26610,ENSG00000109911.18,ELP4,11,,Mesodermal Commitment Pathway,HATs acetylate histones,4,High,1
Q9NP77,RNA polymerase II subunit A C-terminal domain phosphatase SSU72 OS=Homo sapiens OX=9606 GN=SSU72 PE=1 SV=1,0.001,8.566,13,2,3,2,194,22.6,5.33,869,,2,,metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,Pf04722,29101,ENSG00000160075.11,SSU72,1,mRNA surveillance pathway,,RNA polymerase II transcribes snRNA genes,4,High,1
Q99942,E3 ubiquitin-protein ligase RNF5 OS=Homo sapiens OX=9606 GN=RNF5 PE=1 SV=1,0.001,8.555,8,1,4,1,180,19.9,6.65,3298,,1,,metabolic process;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;membrane;mitochondrion,catalytic activity;metal ion binding;protein binding,"Pf00097, Pf13445, Pf13639, Pf13920, Pf13923, Pf14634",6048,ENSG00000228405.5; ENSG00000228907.5; ENSG00000183574.12; ENSG00000204308.7; ENSG00000227277.9; ENSG00000225452.5; ENSG00000223767.5,RNF5,6; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_APD_CTG1,Protein processing in endoplasmic reticulum,,ER Quality Control Compartment (ERQC); ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis,13,High,1
Q9H9Y2,Ribosome production factor 1 OS=Homo sapiens OX=9606 GN=RPF1 PE=1 SV=2,0.001,8.55,8,3,6,3,349,40.1,10.01,2403,,3,,cell organization and biogenesis;metabolic process,nucleus,protein binding;RNA binding,Pf04427,80135,ENSG00000117133.10,RPF1,1,,,,0,High,1
P06276,Cholinesterase OS=Homo sapiens OX=9606 GN=BCHE PE=1 SV=1,0.001,8.53,5,2,5,2,602,68.4,7.42,1885,,2,,cell differentiation;metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;extracellular;membrane;organelle lumen,catalytic activity;protein binding,"Pf00135, Pf07859, Pf08674",590,ENSG00000114200.9,BCHE,3,,Irinotecan Pathway,"Synthesis of PC; Synthesis, secretion, and deacylation of Ghrelin; Neurotransmitter clearance",12,High,1
Q9NUL5,Shiftless antiviral inhibitor of ribosomal frameshifting protein OS=Homo sapiens OX=9606 GN=SHFL PE=1 SV=2,0.001,8.529,10,3,8,3,291,33.1,7.25,2598,,3,,defense response;regulation of biological process;response to stimulus,cytoplasm;nucleus,protein binding;RNA binding,Pf15135,55337,ENSG00000130813.17,C19orf66,19,,,,0,High,1
Q9HCK8,Chromodomain-helicase-DNA-binding protein 8 OS=Homo sapiens OX=9606 GN=CHD8 PE=1 SV=5,0.001,8.527,2,4,37,3,2581,290.3,6.47,13310,,4,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding,"Pf00176, Pf00271, Pf00385, Pf07533, Pf11496",57680,ENSG00000100888.12,CHD8,14,Wnt signaling pathway,,Deactivation of the beta-catenin transactivating complex,5,High,1
Q9NZK5,Adenosine deaminase 2 OS=Homo sapiens OX=9606 GN=ADA2 PE=1 SV=2,0.001,8.526,4,2,16,2,511,58.9,7.91,6625,,2,,development;metabolic process;regulation of biological process;transport,cytosol;extracellular;organelle lumen,catalytic activity;metal ion binding;protein binding,"Pf00962, Pf08451",51816,ENSG00000093072.15,CECR1; ADA2,22,Metabolic pathways; Purine metabolism,,Surfactant metabolism; Neutrophil degranulation,7,High,1
Q86WV6,Stimulator of interferon genes protein OS=Homo sapiens OX=9606 GN=TMEM173 PE=1 SV=1,0.001,8.522,10,3,10,3,379,42.2,7.05,4454,,3,,cell death;defense response;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;Golgi;membrane;mitochondrion,nucleotide binding;protein binding,Pf15009,340061,ENSG00000184584.12,TMEM173,5,RIG-I-like receptor signaling pathway; NOD-like receptor signaling pathway; Cytosolic DNA-sensing pathway,RIG-I-like Receptor Signaling,STAT6-mediated induction of chemokines; Neutrophil degranulation; IRF3-mediated induction of type I IFN; Regulation of innate immune responses to cytosolic DNA,12,High,1
Q9C040,Tripartite motif-containing protein 2 OS=Homo sapiens OX=9606 GN=TRIM2 PE=1 SV=1,0.001,8.518,3,2,5,2,744,81.5,6.96,1602,,2,,metabolic process;regulation of biological process,cytoplasm,catalytic activity;metal ion binding;protein binding,"Pf00097, Pf00630, Pf00643, Pf01436, Pf08450, Pf10174, Pf13445, Pf13639, Pf13920, Pf13923, Pf14634, Pf15227",23321,ENSG00000109654.14,TRIM2,4,,,Interferon gamma signaling,4,High,1
P16157-23,Isoform 23 of Ankyrin-1 OS=Homo sapiens OX=9606 GN=ANK1,0.001,8.517,17,1,1,1,156,17.8,4.87,,3.46,,1,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoskeleton;cytosol;endoplasmic reticulum;membrane;nucleus,protein binding;structural molecule activity,,286,ENSG00000029534.19,ANK1,8,,,,0,High,1
Q96BR5,Cytochrome c oxidase assembly factor 7 OS=Homo sapiens OX=9606 GN=COA7 PE=1 SV=2,0.001,8.514,8,2,14,2,231,25.7,6.02,4592,,2,,,mitochondrion;nucleus,protein binding,,65260,ENSG00000162377.5,SELRC1; COA7,1,,,,0,High,1
Q9UPN7,Serine/threonine-protein phosphatase 6 regulatory subunit 1 OS=Homo sapiens OX=9606 GN=PPP6R1 PE=1 SV=5,0.001,8.508,4,3,12,3,881,96.7,4.55,4130,0,2,1,cell organization and biogenesis;regulation of biological process,cytoplasm;cytosol;membrane,protein binding,"Pf03154, Pf04499, Pf04652, Pf05109, Pf09786",22870,ENSG00000105063.18,PPP6R1,19,,,COPII (Coat Protein 2) Mediated Vesicle Transport,8,High,1
Q9NYG2,Palmitoyltransferase ZDHHC3 OS=Homo sapiens OX=9606 GN=ZDHHC3 PE=1 SV=2,0.001,8.504,10,2,5,2,299,34.1,8.18,1804,,2,,metabolic process;transport,Golgi;membrane,catalytic activity;metal ion binding,Pf01529,51304,ENSG00000280674.2; ENSG00000163812.13,ZDHHC3,3; CHR_HG2066_PATCH,,,,0,High,1
Q3MHD2,Protein LSM12 homolog OS=Homo sapiens OX=9606 GN=LSM12 PE=1 SV=2,0.001,8.481,7,1,5,1,195,21.7,7.74,2249,,1,,,,,Pf09793,124801; 653122,ENSG00000161654.9,LSM12; LSM12P1,17; 8,,,,0,High,1
Q92551,Inositol hexakisphosphate kinase 1 OS=Homo sapiens OX=9606 GN=IP6K1 PE=1 SV=3,0.001,8.477,7,2,4,2,441,50.2,7.24,1592,,2,,metabolic process,cytoplasm;cytosol;nucleus,catalytic activity;nucleotide binding;protein binding,Pf03770,9807,ENSG00000176095.11,IP6K1,3,Phosphatidylinositol signaling system,,Synthesis of IPs in the nucleus; Synthesis of pyrophosphates in the cytosol,5,High,1
Q86VY4,Testis-specific Y-encoded-like protein 5 OS=Homo sapiens OX=9606 GN=TSPYL5 PE=1 SV=2,0.001,8.472,10,2,4,2,417,45.1,9.54,1277,,2,,cell organization and biogenesis;regulation of biological process;response to stimulus,nucleus,protein binding,Pf00956,85453,ENSG00000180543.4,TSPYL5,8,,,,0,High,1
Q92796-2,Isoform 2 of Disks large homolog 3 OS=Homo sapiens OX=9606 GN=DLG3,0.001,8.46,6,3,15,1,512,57.9,9.25,5004,,3,,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytosol;membrane,catalytic activity;protein binding;transporter activity,"Pf00018, Pf00595, Pf00625, Pf07653, Pf13180",1741,ENSG00000082458.11,DLG3,X,,,,0,High,1
P23083,Immunoglobulin heavy variable 1-2 OS=Homo sapiens OX=9606 GN=IGHV1-2 PE=1 SV=2,0.001,8.454,18,2,11,1,117,13.1,9.13,4540,,2,,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity,,388077,ENSG00000211934.3; ENSG00000282550.1,IGHV1OR15-1,14; CHR_HSCHR14_3_CTG1; 15,,,FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis,26,High,1
P49459,Ubiquitin-conjugating enzyme E2 A OS=Homo sapiens OX=9606 GN=UBE2A PE=1 SV=2,0.001,8.451,18,3,9,3,152,17.3,5.15,2570,,3,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;cytosol,catalytic activity;nucleotide binding;protein binding,"Pf00179, Pf14461",7319,ENSG00000077721.15,UBE2A,X,Ubiquitin mediated proteolysis,,Synthesis of active ubiquitin: roles of E1 and E2 enzymes; E3 ubiquitin ligases ubiquitinate target proteins; Antigen processing: Ubiquitination & Proteasome degradation,10,High,1
P17948,Vascular endothelial growth factor receptor 1 OS=Homo sapiens OX=9606 GN=FLT1 PE=1 SV=2,0.001,8.449,2,2,4,2,1338,150.7,8.38,1125,0,2,1,cell differentiation;cellular component movement;development;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;endosome;extracellular;membrane,catalytic activity;nucleotide binding;protein binding;receptor activity;signal transducer activity,"Pf00047, Pf00069, Pf07679, Pf07686, Pf07714, Pf13895, Pf13927",2321,ENSG00000102755.11,FLT1,13,Focal adhesion; HIF-1 signaling pathway; Rheumatoid arthritis; Transcriptional misregulation in cancer; Cytokine-cytokine receptor interaction; PI3K-Akt signaling pathway; Ras signaling pathway; Rap1 signaling pathway; Endocytosis,Angiogenesis; Focal Adhesion; Imatinib and Chronic Myeloid Leukemia; VEGFA-VEGFR2 Signaling Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,Neurophilin interactions with VEGF and VEGFR; VEGF binds to VEGFR leading to receptor dimerization,20,High,1
Q53ET0,CREB-regulated transcription coactivator 2 OS=Homo sapiens OX=9606 GN=CRTC2 PE=1 SV=2,0.001,8.449,7,3,5,3,693,73.3,7.11,1679,,3,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;nucleus,protein binding,"Pf12884, Pf12885, Pf12886",200186,ENSG00000160741.16,CRTC2,1,HTLV-I infection; PI3K-Akt signaling pathway; AMPK signaling pathway; Glucagon signaling pathway; Insulin resistance,AMP-activated Protein Kinase (AMPK) Signaling; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,Transcriptional activation of mitochondrial biogenesis; Circadian Clock,11,High,1
Q9NQA5,Transient receptor potential cation channel subfamily V member 5 OS=Homo sapiens OX=9606 GN=TRPV5 PE=1 SV=2,0.001,8.448,2,2,72,1,729,82.5,6.46,33798,,2,,cell organization and biogenesis;cellular homeostasis;transport,membrane,metal ion binding;protein binding;transporter activity,"Pf00023, Pf00520, Pf12796, Pf13606, Pf13637, Pf13857",56302,,TRPV5,7,Endocrine and other factor-regulated calcium reabsorption,Osteoclast Signaling,TRP channels,6,High,1
Q9UKA4,A-kinase anchor protein 11 OS=Homo sapiens OX=9606 GN=AKAP11 PE=1 SV=1,0.001,8.446,2,3,5,3,1901,210.4,5.39,1506,,3,,regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane,protein binding,Pf05716,11215,ENSG00000023516.8,AKAP11,13,,G Protein Signaling Pathways,,1,High,1
Q9NRN5,Olfactomedin-like protein 3 OS=Homo sapiens OX=9606 GN=OLFML3 PE=2 SV=1,0.001,8.44,8,3,9,3,406,46,6.57,3144,,3,,development,extracellular,,Pf02191,56944,ENSG00000116774.11,OLFML3,1,,,,0,High,1
Q6RW13,Type-1 angiotensin II receptor-associated protein OS=Homo sapiens OX=9606 GN=AGTRAP PE=1 SV=1,0.001,8.439,25,2,7,2,159,17.4,6.14,2212,,2,,regulation of biological process;response to stimulus,cytosol;endoplasmic reticulum;Golgi;membrane,protein binding;receptor activity;signal transducer activity,Pf06396,57085,ENSG00000177674.15,AGTRAP,1,,,Signaling by BRAF and RAF fusions,4,High,1
Q8N6C5,Immunoglobulin superfamily member 1 OS=Homo sapiens OX=9606 GN=IGSF1 PE=1 SV=3,0.001,8.433,1,1,6,1,1336,148.8,5.9,2564,,1,,regulation of biological process;response to stimulus,extracellular;membrane,protein binding;receptor activity;signal transducer activity,"Pf00047, Pf07679, Pf13895, Pf13927",3547,ENSG00000147255.18,IGSF1,X,,,,0,High,1
Q86T03,"Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase OS=Homo sapiens OX=9606 GN=PIP4P1 PE=1 SV=1",0.001,8.428,8,1,5,1,277,29.5,8.91,2683,,1,,metabolic process,endosome;membrane;vacuole,catalytic activity,Pf09788,90809,ENSG00000165782.10,TMEM55B; PIP4P1,14,Phosphatidylinositol signaling system,,Synthesis of PIPs in the nucleus; PI5P Regulates TP53 Acetylation,13,High,1
P47224,Guanine nucleotide exchange factor MSS4 OS=Homo sapiens OX=9606 GN=RABIF PE=1 SV=2,0.001,8.426,15,2,8,2,123,13.8,5.52,3116,,2,,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytosol;membrane,metal ion binding;protein binding,Pf04421,5877,ENSG00000183155.4,RABIF,1,,Retinoblastoma (RB) in Cancer,,1,High,1
O15018,PDZ domain-containing protein 2 OS=Homo sapiens OX=9606 GN=PDZD2 PE=1 SV=4,0.001,8.424,1,2,5,2,2839,301.5,7.43,1584,,2,,,cytoplasm;endoplasmic reticulum;extracellular;nucleus,protein binding,"Pf00595, Pf13180",23037,ENSG00000133401.15,PDZD2,5,,,,0,High,1
P60059,Protein transport protein Sec61 subunit gamma OS=Homo sapiens OX=9606 GN=SEC61G PE=1 SV=1,0.001,8.41,18,1,24,1,68,7.7,9.99,10129,,1,,transport,cytosol;endoplasmic reticulum;membrane,protein binding;transporter activity,Pf00584,23480,ENSG00000132432.13,SEC61G,7,Protein processing in endoplasmic reticulum; Vibrio cholerae infection; Protein export; Phagosome,,ER-Phagosome pathway; XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane,15,High,1
Q15388,Mitochondrial import receptor subunit TOM20 homolog OS=Homo sapiens OX=9606 GN=TOMM20 PE=1 SV=1,0.001,8.393,28,3,101,3,145,16.3,8.6,36254,,3,,cell communication;cell organization and biogenesis;metabolic process;response to stimulus;transport,membrane;mitochondrion,protein binding;transporter activity,Pf02064,9804,ENSG00000173726.10,TOMM20,1,,,Ub-specific processing proteases; Mitochondrial protein import; Pink/Parkin Mediated Mitophagy,7,High,1
O95453,Poly(A)-specific ribonuclease PARN OS=Homo sapiens OX=9606 GN=PARN PE=1 SV=1,0.001,8.389,3,2,4,2,639,73.4,6.2,2264,,2,,metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;protein binding;RNA binding,"Pf04857, Pf08675",5073,ENSG00000140694.16; ENSG00000274829.4,PARN,16; CHR_HSCHR16_1_CTG1,RNA degradation,Lung fibrosis,ATF4 activates genes; Deadenylation of mRNA; KSRP (KHSRP) binds and destabilizes mRNA,11,High,1
P04440,"HLA class II histocompatibility antigen, DP beta 1 chain OS=Homo sapiens OX=9606 GN=HLA-DPB1 PE=1 SV=1",0.001,8.376,8,2,16,2,258,29.1,8.57,7647,,2,,regulation of biological process;response to stimulus,cell surface;endoplasmic reticulum;endosome;Golgi;membrane;vacuole,,"Pf00969, Pf07654, Pf08205",3115,ENSG00000226826.10; ENSG00000237710.10; ENSG00000223865.10,HLA-DPB1,6; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_DBB_CTG1,Leishmaniasis; Staphylococcus aureus infection; Hematopoietic cell lineage; Systemic lupus erythematosus; Th1 and Th2 cell differentiation; Toxoplasmosis; Rheumatoid arthritis; Cell adhesion molecules (CAMs); Influenza A; Epstein-Barr virus infection; Viral myocarditis; Asthma; Autoimmune thyroid disease; HTLV-I infection; Intestinal immune network for IgA production; Type I diabetes mellitus; Allograft rejection; Inflammatory bowel disease (IBD); Antigen processing and presentation; Graft-versus-host disease; Herpes simplex infection; Phagosome; Tuberculosis,Allograft Rejection,PD-1 signaling; Translocation of ZAP-70 to Immunological synapse; MHC class II antigen presentation; Downstream TCR signaling; Generation of second messenger molecules; Interferon gamma signaling; Phosphorylation of CD3 and TCR zeta chains,37,High,1
Q6P3S6,F-box only protein 42 OS=Homo sapiens OX=9606 GN=FBXO42 PE=1 SV=1,0.001,8.375,6,3,4,3,717,77.8,7.43,1210,,3,,,,protein binding,"Pf00646, Pf01344, Pf07646, Pf12937, Pf13415, Pf13418, Pf13854, Pf13964",54455,ENSG00000037637.10,FBXO42,1,,,,0,High,1
Q86WB0,Nuclear-interacting partner of ALK OS=Homo sapiens OX=9606 GN=ZC3HC1 PE=1 SV=1,0.001,8.368,5,2,6,2,502,55.2,5.62,2876,,2,,cell division;metabolic process;regulation of biological process,membrane;nucleus,metal ion binding;protein binding,"Pf07967, Pf08600",51530,ENSG00000091732.15,ZC3HC1,7,,,,0,High,1
Q13443,Disintegrin and metalloproteinase domain-containing protein 9 OS=Homo sapiens OX=9606 GN=ADAM9 PE=1 SV=1,0.001,8.368,4,3,8,3,819,90.5,7.52,2859,,3,,cell differentiation;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cell surface;extracellular;membrane,catalytic activity;metal ion binding;protein binding,"Pf00200, Pf01421, Pf01562, Pf08516, Pf13574, Pf13582, Pf13583, Pf13688",8754,ENSG00000168615.11,ADAM9,8,,Copper homeostasis,Collagen degradation,4,High,1
Q6ZSY5,Protein phosphatase 1 regulatory subunit 3F OS=Homo sapiens OX=9606 GN=PPP1R3F PE=1 SV=3,0.001,8.366,4,2,3,2,799,82.7,4.6,1257,,2,,regulation of biological process,membrane,protein binding,Pf03370,89801,ENSG00000049769.12,PPP1R3F,X,Insulin signaling pathway,,,1,High,1
Q9NVN3-1,Isoform 1 of Synembryn-B OS=Homo sapiens OX=9606 GN=RIC8B,0.001,8.365,4,2,5,1,536,60.8,5.88,2059,,2,,regulation of biological process,cytosol;membrane,enzyme regulator activity;protein binding,Pf10165,55188,ENSG00000111785.19,RIC8B,12,,,,0,High,1
Q8IVI9,Nostrin OS=Homo sapiens OX=9606 GN=NOSTRIN PE=1 SV=2,0.001,8.355,5,2,4,2,506,57.6,8.97,1454,,2,,regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;membrane;nucleus,DNA binding;protein binding,"Pf00018, Pf07653, Pf14604",115677,ENSG00000163072.15,NOSTRIN,2,,,NOSTRIN mediated eNOS trafficking,4,High,1
Q96ES7,SAGA-associated factor 29 OS=Homo sapiens OX=9606 GN=SGF29 PE=1 SV=1,0.001,8.354,14,3,18,3,293,33.2,8.1,6295,,3,,cell organization and biogenesis;metabolic process;regulation of biological process,nucleus,protein binding,Pf07039,112869,ENSG00000176476.8,CCDC101; SGF29,16,,,HATs acetylate histones,3,High,1
O94766,Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 OS=Homo sapiens OX=9606 GN=B3GAT3 PE=1 SV=2,0.001,8.346,6,2,8,2,335,37.1,8.27,2899,,2,,metabolic process;regulation of biological process,Golgi;membrane,catalytic activity;enzyme regulator activity;metal ion binding;protein binding,Pf03360,26229,ENSG00000149541.9,B3GAT3,11,Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate; Glycosaminoglycan biosynthesis - heparan sulfate / heparin; Metabolic pathways,,A tetrasaccharide linker sequence is required for GAG synthesis; Defective B3GAT3 causes JDSSDHD,13,High,1
Q9GZP9,Derlin-2 OS=Homo sapiens OX=9606 GN=DERL2 PE=1 SV=1,0.001,8.339,13,1,4,1,239,27.5,7.28,2547,,1,,metabolic process;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;endosome;membrane,catalytic activity;protein binding,Pf04511,51009,ENSG00000072849.10,DERL2,17,Protein processing in endoplasmic reticulum,,Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; ER Quality Control Compartment (ERQC); ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Hedgehog ligand biogenesis,19,High,1
O60307,Microtubule-associated serine/threonine-protein kinase 3 OS=Homo sapiens OX=9606 GN=MAST3 PE=1 SV=2,0.001,8.335,4,3,4,1,1309,143,8.06,763,1.89,2,1,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf00595, Pf07714, Pf08926, Pf13180, Pf14531",23031,ENSG00000099308.10,MAST3,19,,,,0,High,1
P55212,Caspase-6 OS=Homo sapiens OX=9606 GN=CASP6 PE=1 SV=2,0.001,8.33,10,2,5,2,293,33.3,6.93,2104,,2,,cell death;cell differentiation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,catalytic activity;protein binding,Pf00656,839,ENSG00000138794.9,CASP6,4,Apoptosis,Parkinsons Disease Pathway; Nanomaterial induced apoptosis; Apoptosis; Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation; MAPK Signaling Pathway; Apoptosis Modulation by HSP70,Caspase-mediated cleavage of cytoskeletal proteins; TP53 Regulates Transcription of Caspase Activators and Caspases; Breakdown of the nuclear lamina,19,High,1
Q9NWY4,Histone PARylation factor 1 OS=Homo sapiens OX=9606 GN=HPF1 PE=1 SV=2,0.001,8.328,8,2,5,2,346,39.4,6.8,1834,,2,,metabolic process;regulation of biological process;response to stimulus,nucleus,protein binding,Pf10228,54969,ENSG00000056050.6,C4orf27; HPF1,4,,,,0,High,1
Q8WVX3,Uncharacterized protein C4orf3 OS=Homo sapiens OX=9606 GN=C4orf3 PE=1 SV=2,0.001,8.324,17,1,8,1,66,7.6,5.29,4312,,1,,,membrane,,,401152,ENSG00000164096.12,C4orf3,4,,,,0,High,1
Q15847,Adipogenesis regulatory factor OS=Homo sapiens OX=9606 GN=ADIRF PE=1 SV=1,0.001,8.32,18,1,9,1,76,7.9,5.31,4280,,1,,cell differentiation;metabolic process;regulation of biological process;response to stimulus,cytosol;nucleus,,,10974,ENSG00000148671.13,ADIRF; C10orf116,10,,,Transcriptional regulation of white adipocyte differentiation,2,High,1
P08567,Pleckstrin OS=Homo sapiens OX=9606 GN=PLEK PE=1 SV=3,0.001,8.302,11,2,4,2,350,40.1,8.28,1307,,2,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;membrane,protein binding,"Pf00169, Pf00610, Pf15406, Pf15410",5341,ENSG00000115956.9,PLEK,2,,Serotonin and anxiety-related events; TYROBP Causal Network; Serotonin and anxiety,Platelet degranulation,7,High,1
Q9H7N4,"Splicing factor, arginine/serine-rich 19 OS=Homo sapiens OX=9606 GN=SCAF1 PE=1 SV=3",0.001,8.292,2,2,3,2,1312,139.2,9.25,964,,2,,metabolic process,nucleus,protein binding;RNA binding,,58506,ENSG00000126461.14,SCAF1,19,,,,0,High,1
Q99549,M-phase phosphoprotein 8 OS=Homo sapiens OX=9606 GN=MPHOSPH8 PE=1 SV=2,0.001,8.288,5,3,4,3,860,97.1,6.06,1224,,3,,metabolic process;regulation of biological process,chromosome;cytoplasm;cytosol;membrane;nucleus,catalytic activity;protein binding,"Pf00023, Pf00385, Pf12796, Pf13606, Pf13637, Pf13857",54737,ENSG00000196199.13,MPHOSPH8,13,,,,0,High,1
Q9Y587,AP-4 complex subunit sigma-1 OS=Homo sapiens OX=9606 GN=AP4S1 PE=1 SV=1,0.001,8.287,7,1,11,1,144,17,5.19,7048,,1,,transport,Golgi;membrane;organelle lumen,transporter activity,Pf01217,11154,ENSG00000100478.14,AP4S1,14,Lysosome,,Lysosome Vesicle Biogenesis,6,High,1
Q96B26,Exosome complex component RRP43 OS=Homo sapiens OX=9606 GN=EXOSC8 PE=1 SV=1,0.001,8.285,7,2,4,2,276,30,5.3,1638,,2,,metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;protein binding;RNA binding,"Pf01138, Pf03725",11340,ENSG00000120699.12,EXOSC8,13,RNA degradation,,"Major pathway of rRNA processing in the nucleolus and cytosol; mRNA decay by 3' to 5' exoribonuclease; ATF4 activates genes; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; KSRP (KHSRP) binds and destabilizes mRNA",15,High,1
Q9H9V9,2-oxoglutarate and iron-dependent oxygenase JMJD4 OS=Homo sapiens OX=9606 GN=JMJD4 PE=1 SV=2,0.001,8.282,7,2,6,2,463,52.5,6.21,1913,,2,,,,protein binding,"Pf02373, Pf13621",65094,ENSG00000081692.12,JMJD4,1,,,,0,High,1
O43310,CBP80/20-dependent translation initiation factor OS=Homo sapiens OX=9606 GN=CTIF PE=1 SV=1,0.001,8.275,5,3,6,3,598,67.5,6.54,2127,,3,,metabolic process;regulation of biological process,cytoplasm;cytosol,protein binding;RNA binding,Pf02854,9811,ENSG00000282825.1; ENSG00000134030.13,CTIF,18; CHR_HG2213_PATCH,,,,0,High,1
O15540,"Fatty acid-binding protein, brain OS=Homo sapiens OX=9606 GN=FABP7 PE=1 SV=3",0.001,8.269,11,2,57,1,132,14.9,5.59,33182,,2,,cell differentiation;cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus,transporter activity,"Pf00061, Pf14651",2173,ENSG00000164434.11,FABP7,6,PPAR signaling pathway,PPAR signaling pathway,Triglyceride catabolism,6,High,1
Q86TB3,Alpha-protein kinase 2 OS=Homo sapiens OX=9606 GN=ALPK2 PE=1 SV=3,0.001,8.268,1,2,117,1,2170,236.9,5.24,51775,0,1,1,metabolic process,cytoplasm,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding;receptor activity;signal transducer activity,"Pf02816, Pf07679, Pf13895",115701,ENSG00000198796.6,ALPK2,18,,,,0,High,1
Q9H4X1,Regulator of cell cycle RGCC OS=Homo sapiens OX=9606 GN=RGCC PE=1 SV=1,0.001,8.262,15,2,6,2,137,14.6,4.75,2126,,2,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;nucleus,enzyme regulator activity;protein binding,Pf15151,28984,ENSG00000102760.12,RGCC,13,,,TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain,6,High,1
Q8WVC0,RNA polymerase-associated protein LEO1 OS=Homo sapiens OX=9606 GN=LEO1 PE=1 SV=1,0.001,8.256,3,2,5,2,666,75.4,4.51,1557,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,nucleus,protein binding,"Pf04004, Pf04147",123169,ENSG00000166477.12,LEO1,15,,Endoderm Differentiation,E3 ubiquitin ligases ubiquitinate target proteins; Formation of the beta-catenin:TCF transactivating complex; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events,14,High,1
Q8N0Z8,tRNA pseudouridine synthase-like 1 OS=Homo sapiens OX=9606 GN=PUSL1 PE=1 SV=1,0.001,8.254,11,2,10,2,303,33.2,9.85,2723,,2,,metabolic process,,catalytic activity;RNA binding,Pf01416,126789,ENSG00000169972.11,PUSL1,1,,,,0,High,1
Q9NQI0,Probable ATP-dependent RNA helicase DDX4 OS=Homo sapiens OX=9606 GN=DDX4 PE=1 SV=2,0.001,8.253,2,2,20,1,724,79.3,5.87,10152,,2,,cell differentiation;cell organization and biogenesis;cellular component movement;development;metabolic process;regulation of biological process,cytoplasm,catalytic activity;nucleotide binding,"Pf00270, Pf00271",54514,ENSG00000152670.18,DDX4,5,,,PIWI-interacting RNA (piRNA) biogenesis,3,High,1
P56270,Myc-associated zinc finger protein OS=Homo sapiens OX=9606 GN=MAZ PE=1 SV=1,0.001,8.253,3,1,17,1,477,48.6,8.95,5614,,1,,metabolic process;regulation of biological process,nucleus,DNA binding;metal ion binding;protein binding;RNA binding,Pf13465,4150,ENSG00000103495.13,MAZ,16,,Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,,1,High,1
Q9ULV3,Cip1-interacting zinc finger protein OS=Homo sapiens OX=9606 GN=CIZ1 PE=1 SV=2,0.001,8.251,4,2,3,2,898,100,6.11,1108,,2,,,membrane;nucleus,metal ion binding;protein binding,Pf12171,25792,ENSG00000148337.20,CIZ1,9,,,,0,High,1
Q6PJT7,Zinc finger CCCH domain-containing protein 14 OS=Homo sapiens OX=9606 GN=ZC3H14 PE=1 SV=1,0.001,8.248,5,3,3,3,736,82.8,7.31,1257,,3,,regulation of biological process,cytoplasm;nucleus,metal ion binding;protein binding;RNA binding,Pf14608,79882,ENSG00000100722.18,ZC3H14,14,,,,0,High,1
O43318,Mitogen-activated protein kinase kinase kinase 7 OS=Homo sapiens OX=9606 GN=MAP3K7 PE=1 SV=1,0.001,8.242,5,2,8,2,606,67.2,7.11,2280,,2,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf01636, Pf03962, Pf07714",6885,ENSG00000135341.17,MAP3K7,6,Wnt signaling pathway; Epstein-Barr virus infection; T cell receptor signaling pathway; Adherens junction; NF-kappa B signaling pathway; NOD-like receptor signaling pathway; Herpes simplex infection; Leishmaniasis; Measles; Osteoclast differentiation; AMPK signaling pathway; TNF signaling pathway; Toxoplasmosis; RIG-I-like receptor signaling pathway; MAPK signaling pathway; Toll-like receptor signaling pathway,Regulation of toll-like receptor signaling pathway; IL-1 signaling pathway; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway; IL17 signaling pathway; B Cell Receptor Signaling Pathway; TNF alpha Signaling Pathway; EBV LMP1 signaling; Structural Pathway of Interleukin 1 (IL-1); Cardiac Hypertrophic Response; NLR Proteins; Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation; Wnt Signaling Pathway Netpath; IL-6 signaling pathway; TGF-beta Signaling Pathway; MAPK Signaling Pathway; T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection; RIG-I-like Receptor Signaling; Angiopoietin Like Protein 8 Regulatory Pathway; Wnt Signaling Pathway and Pluripotency; p38 MAPK Signaling Pathway; Insulin Signaling; T-Cell antigen Receptor (TCR)  Signaling Pathway; DNA Damage Response (only ATM dependent); Toll-like receptor signaling pathway,"Downstream TCR signaling; NOD1/2 Signaling Pathway; TRAF6-mediated induction of TAK1 complex within TLR4 complex; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; TNFR1-induced NFkappaB signaling pathway; Activated TLR4 signalling; Interleukin-1 family signaling; activated TAK1 mediates p38 MAPK activation; TICAM1,TRAF6-dependent induction of TAK1 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Ub-specific processing proteases; Ca2+ pathway; IRAK2 mediated activation of TAK1 complex; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; CLEC7A (Dectin-1) signaling",95,High,1
Q9P2P5,E3 ubiquitin-protein ligase HECW2 OS=Homo sapiens OX=9606 GN=HECW2 PE=1 SV=2,0.001,8.237,2,2,4,2,1572,175.7,5.41,1059,2.72,1,1,metabolic process;regulation of biological process,cytoplasm;cytoskeleton,catalytic activity;protein binding,"Pf00168, Pf00397, Pf00632",57520,ENSG00000138411.10,HECW2,2,,,Antigen processing: Ubiquitination & Proteasome degradation,4,High,1
Q9BTE7,DCN1-like protein 5 OS=Homo sapiens OX=9606 GN=DCUN1D5 PE=1 SV=1,0.001,8.23,7,2,16,2,237,27.5,5.58,7698,,2,,metabolic process;regulation of biological process,,protein binding,Pf03556,84259,ENSG00000137692.11,DCUN1D5,11,,,Neddylation,3,High,1
O15431,High affinity copper uptake protein 1 OS=Homo sapiens OX=9606 GN=SLC31A1 PE=1 SV=1,0.001,8.221,10,1,4,1,190,21.1,7.42,1953,,1,,cellular homeostasis;response to stimulus;transport,cytoplasm;endosome;membrane,protein binding;transporter activity,Pf04145,1317,ENSG00000136868.10,SLC31A1,9,Mineral absorption; Platinum drug resistance,Copper homeostasis,Metal ion SLC transporters,7,High,1
Q6ZUM4,Rho GTPase-activating protein 27 OS=Homo sapiens OX=9606 GN=ARHGAP27 PE=1 SV=3,0.001,8.213,2,2,11,2,889,98.3,5.59,3394,0,2,1,regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus,enzyme regulator activity;protein binding,"Pf00018, Pf00169, Pf00397, Pf00620, Pf14604, Pf15410",201176,ENSG00000159314.11; ENSG00000276907.4,ARHGAP27,17; CHR_HSCHR17_2_CTG5,,,Rho GTPase cycle,3,High,1
P49427,Ubiquitin-conjugating enzyme E2 R1 OS=Homo sapiens OX=9606 GN=CDC34 PE=1 SV=2,0.001,8.206,6,2,16,1,236,26.7,4.54,6939,,2,,cell division;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00179, Pf14461",997,ENSG00000099804.8,CDC34,19,Herpes simplex infection; Ubiquitin mediated proteolysis,,Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; CLEC7A (Dectin-1) signaling; FCERI mediated NF-kB activation,17,High,1
Q6PL24,Protein TMED8 OS=Homo sapiens OX=9606 GN=TMED8 PE=1 SV=1,0.001,8.192,8,2,4,2,325,35.7,4.74,1931,,2,,transport,,,Pf13897,283578,ENSG00000100580.7,TMED8,14,,,,0,High,1
O14683,Tumor protein p53-inducible protein 11 OS=Homo sapiens OX=9606 GN=TP53I11 PE=1 SV=2,0.001,8.192,13,2,7,2,189,21,9.55,2233,,2,,regulation of biological process;response to stimulus,membrane,,Pf14936,9537,ENSG00000175274.18,TP53I11,11,,,,0,High,1
Q9H583,HEAT repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=HEATR1 PE=1 SV=3,0.001,8.186,1,2,33,2,2144,242.2,6.54,11501,,2,,metabolic process;regulation of biological process,membrane;mitochondrion;nucleus,protein binding;RNA binding,"Pf08146, Pf12397",55127,ENSG00000119285.10,HEATR1,1,Ribosome biogenesis in eukaryotes,,Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol,6,High,1
A0A0C4DH43,Immunoglobulin heavy variable 2-70D OS=Homo sapiens OX=9606 GN=IGHV2-70D PE=3 SV=1,0.001,8.184,12,2,15,2,119,13.3,8.29,6508,,2,,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,protein binding,,102723168,ENSG00000282482.1; ENSG00000211974.3,IGHV2-70D,14; CHR_HSCHR14_3_CTG1,,,,0,High,1
Q9Y463,Dual specificity tyrosine-phosphorylation-regulated kinase 1B OS=Homo sapiens OX=9606 GN=DYRK1B PE=1 SV=1,0.001,8.183,3,2,5,1,629,69.2,9.13,1914,,2,,metabolic process;regulation of biological process,nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf07714",9149,ENSG00000281320.2; ENSG00000105204.13,DYRK1B,19; CHR_HG2021_PATCH,,,,0,High,1
Q8IYT4,Katanin p60 ATPase-containing subunit A-like 2 OS=Homo sapiens OX=9606 GN=KATNAL2 PE=1 SV=3,0.001,8.182,2,1,103,1,538,61.2,7.56,52010,1.79,1,1,metabolic process;response to stimulus,cytoplasm;cytoskeleton;nucleus,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00004, Pf00910, Pf01057, Pf01078, Pf05496, Pf06068, Pf07724, Pf07728, Pf08513, Pf13479",83473,ENSG00000167216.16,KATNAL2,18,,,,0,High,1
Q7Z449,Cytochrome P450 2U1 OS=Homo sapiens OX=9606 GN=CYP2U1 PE=1 SV=1,0.001,8.18,5,2,5,2,544,61.9,8.4,1751,,2,,metabolic process,endoplasmic reticulum;membrane,catalytic activity;metal ion binding,Pf00067,113612,ENSG00000155016.17,CYP2U1,4,Arachidonic acid metabolism; Metabolic pathways,Oxidation by Cytochrome P450; Metapathway biotransformation,"Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE); Miscellaneous substrates; Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)",17,High,1
A7KAX9,Rho GTPase-activating protein 32 OS=Homo sapiens OX=9606 GN=ARHGAP32 PE=1 SV=1,0.001,8.176,1,2,96,2,2087,230.4,6.74,34114,,2,,regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;endosome;Golgi;membrane,enzyme regulator activity;protein binding,"Pf00018, Pf00620, Pf07653, Pf14604",9743,ENSG00000134909.18,ARHGAP32,11,,,Rho GTPase cycle,3,High,1
Q99487,"Platelet-activating factor acetylhydrolase 2, cytoplasmic OS=Homo sapiens OX=9606 GN=PAFAH2 PE=1 SV=1",0.001,8.175,7,2,3,2,392,44,6.89,1406,,2,,coagulation;metabolic process;regulation of biological process,cytoplasm;membrane,catalytic activity,"Pf00326, Pf03403, Pf12695, Pf12697",5051,ENSG00000158006.13,PAFAH2,1,Ether lipid metabolism; Metabolic pathways,,Platelet homeostasis,4,High,1
Q9BZ72,Membrane-associated phosphatidylinositol transfer protein 2 OS=Homo sapiens OX=9606 GN=PITPNM2 PE=1 SV=1,0.001,8.158,2,2,2,2,1349,148.8,7.17,923,,2,,metabolic process;transport,cytosol;membrane,metal ion binding;transporter activity,"Pf02121, Pf02862, Pf08235",57605,ENSG00000090975.12,PITPNM2,12,,,Synthesis of PI,5,High,1
P11308,Transcriptional regulator ERG OS=Homo sapiens OX=9606 GN=ERG PE=1 SV=2,0.001,8.156,4,1,7,1,486,54.6,7.47,3830,,1,,cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;development;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,DNA binding;protein binding;signal transducer activity,"Pf00178, Pf02198",2078,ENSG00000157554.18,ERG,21,Transcriptional misregulation in cancer,TarBasePathway; VEGFA-VEGFR2 Signaling Pathway,,3,High,1
C9JRZ8,Aldo-keto reductase family 1 member B15 OS=Homo sapiens OX=9606 GN=AKR1B15 PE=1 SV=2,0.001,8.145,5,2,146,1,316,36.5,6.7,70984,,2,,metabolic process,cytoplasm;cytosol;mitochondrion;organelle lumen,catalytic activity,Pf00248,441282,,AKR1B15,7,,,Estrogen biosynthesis,5,High,1
Q8N806,Putative E3 ubiquitin-protein ligase UBR7 OS=Homo sapiens OX=9606 GN=UBR7 PE=1 SV=2,0.001,8.145,5,2,5,2,425,48,4.81,2776,,2,,metabolic process,,catalytic activity;metal ion binding,Pf02207,55148,ENSG00000278787.4; ENSG00000012963.14,UBR7,14; CHR_HSCHR14_7_CTG1,,,,0,High,1
Q96F15,GTPase IMAP family member 5 OS=Homo sapiens OX=9606 GN=GIMAP5 PE=1 SV=1,0.001,8.132,15,3,5,3,307,34.8,7.68,1419,,3,,,membrane;mitochondrion;vacuole,nucleotide binding;protein binding,"Pf01926, Pf04548",55340,ENSG00000196329.11,GIMAP5,7,,,,0,High,1
Q6ZRF8,RING finger protein 207 OS=Homo sapiens OX=9606 GN=RNF207 PE=1 SV=2,0.001,8.111,4,2,6,1,634,70.8,6.68,1023,3.05,1,1,cell communication;regulation of biological process,cytoplasm,metal ion binding;protein binding,"Pf00643, Pf13639, Pf14634",388591,ENSG00000158286.12,RNF207,1,,,,0,High,1
Q13158,FAS-associated death domain protein OS=Homo sapiens OX=9606 GN=FADD PE=1 SV=1,0.001,8.105,11,2,5,2,208,23.3,5.69,2857,,2,,cell death;cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,protein binding,"Pf00531, Pf01335",8772,ENSG00000168040.4,FADD,11,Apoptosis; NOD-like receptor signaling pathway; Toll-like receptor signaling pathway; Apoptosis - multiple species; Chagas disease (American trypanosomiasis); Platinum drug resistance; Hepatitis B; Herpes simplex infection; TNF signaling pathway; Alzheimer's disease; Tuberculosis; Pathways in cancer; RIG-I-like receptor signaling pathway,Regulation of toll-like receptor signaling pathway; Integrated Breast Cancer Pathway; TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway; Alzheimers Disease; TNF alpha Signaling Pathway; Nanomaterial induced apoptosis; Nanoparticle triggered regulated necrosis; Apoptosis; Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation; Apoptosis Modulation by HSP70; RIG-I-like Receptor Signaling; VEGFA-VEGFR2 Signaling Pathway; Toll-like receptor signaling pathway,TLR3-mediated TICAM1-dependent programmed cell death; FasL/ CD95L signaling; TRAIL  signaling; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; TNFR1-induced proapoptotic signaling; Activated TLR4 signalling; Dimerization of procaspase-8; TRIF-mediated programmed cell death; Regulation by c-FLIP; CASP8 activity is inhibited,54,High,1
Q96GC9,Vacuole membrane protein 1 OS=Homo sapiens OX=9606 GN=VMP1 PE=1 SV=1,0.001,8.097,6,2,7,2,406,46.2,6.95,4035,,2,,cell organization and biogenesis;metabolic process;transport,endoplasmic reticulum;membrane;vacuole,protein binding,Pf09335,81671,ENSG00000062716.12,VMP1,17,,Nanoparticle triggered autophagic cell death,,1,High,1
Q9NYP7,Elongation of very long chain fatty acids protein 5 OS=Homo sapiens OX=9606 GN=ELOVL5 PE=1 SV=1,0.001,8.095,4,1,4,1,299,35.3,9.42,1726,,1,,metabolic process;regulation of biological process,endoplasmic reticulum;membrane,catalytic activity;protein binding,Pf01151,60481,ENSG00000012660.13,ELOVL5,6,Biosynthesis of unsaturated fatty acids; Fatty acid elongation; Fatty acid metabolism,,Synthesis of very long-chain fatty acyl-CoAs; Linoleic acid (LA) metabolism; alpha-linolenic acid (ALA) metabolism,11,High,1
P42331,Rho GTPase-activating protein 25 OS=Homo sapiens OX=9606 GN=ARHGAP25 PE=1 SV=2,0.001,8.082,3,2,8,2,645,73.4,6.37,2573,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytosol,enzyme regulator activity,"Pf00169, Pf00620, Pf04111, Pf15409, Pf15413",9938,,ARHGAP25,2,,,Rho GTPase cycle,3,High,1
P49796,Regulator of G-protein signaling 3 OS=Homo sapiens OX=9606 GN=RGS3 PE=1 SV=2,0.001,8.067,3,3,7,3,1198,132.3,6.28,1728,,3,,regulation of biological process;transport,cytoplasm;cytosol;membrane;nucleus,enzyme regulator activity;protein binding,"Pf00168, Pf00595, Pf00615, Pf03154, Pf04652, Pf07415, Pf13180",5998,ENSG00000138835.22,RGS3,9,Axon guidance,Myometrial Relaxation and Contraction Pathways; Calcium Regulation in the Cardiac Cell,Gastrin-CREB signalling pathway via PKC and MAPK,8,High,1
Q9BV35,Calcium-binding mitochondrial carrier protein SCaMC-3 OS=Homo sapiens OX=9606 GN=SLC25A23 PE=1 SV=2,0.001,8.047,3,2,10,2,468,52.3,7.33,4371,,2,,regulation of biological process;response to stimulus;transport,membrane;mitochondrion,metal ion binding;protein binding;transporter activity,"Pf00036, Pf00153, Pf13202, Pf13405, Pf13499, Pf13833",79085,ENSG00000125648.14,SLC25A23,19,,,,0,High,1
Q9BX67,Junctional adhesion molecule C OS=Homo sapiens OX=9606 GN=JAM3 PE=1 SV=1,0.001,8.044,12,3,15,3,310,35,7.59,5404,,3,,cell differentiation;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,extracellular;membrane,protein binding,"Pf00047, Pf07679, Pf07686, Pf08205, Pf13895, Pf13927",83700,ENSG00000166086.12,JAM3,11,Epithelial cell signaling in Helicobacter pylori infection; Cell adhesion molecules (CAMs); Leukocyte transendothelial migration; Tight junction,,Integrin cell surface interactions; Cell surface interactions at the vascular wall,8,High,1
Q6XZF7,Dynamin-binding protein OS=Homo sapiens OX=9606 GN=DNMBP PE=1 SV=1,0.001,8.037,2,2,21,2,1577,177.2,5.39,5857,,2,,regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;Golgi,protein binding,"Pf00018, Pf00621, Pf03114, Pf07653, Pf14604",23268,ENSG00000107554.16,DNMBP,10,,,,0,High,1
Q8TB72,Pumilio homolog 2 OS=Homo sapiens OX=9606 GN=PUM2 PE=1 SV=2,0.001,8.031,3,2,6,2,1066,114.1,7.08,1796,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,protein binding;RNA binding,Pf00806,23369,,PUM2,2,,,Neddylation,3,High,1
P20594,Atrial natriuretic peptide receptor 2 OS=Homo sapiens OX=9606 GN=NPR2 PE=1 SV=1,0.001,8.017,2,1,4,1,1047,116.9,6.87,1526,,1,,metabolic process;regulation of biological process;response to stimulus,membrane,catalytic activity;nucleotide binding;protein binding;receptor activity;signal transducer activity,"Pf00069, Pf00211, Pf01094, Pf07701, Pf07714",4882,ENSG00000159899.14,NPR2,9,Oxytocin signaling pathway; cGMP-PKG signaling pathway; Purine metabolism; Vascular smooth muscle contraction,,Physiological factors,7,High,1
P16591,Tyrosine-protein kinase Fer OS=Homo sapiens OX=9606 GN=FER PE=1 SV=2,0.001,8.008,3,2,3,2,822,94.6,7.14,1373,,2,,cell communication;cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00017, Pf00069, Pf00611, Pf07714",2241,ENSG00000151422.12,FER,5,Adherens junction,,Signaling by SCF-KIT,4,High,1
O14920,Inhibitor of nuclear factor kappa-B kinase subunit beta OS=Homo sapiens OX=9606 GN=IKBKB PE=1 SV=1,0.001,8.006,4,3,5,3,756,86.5,5.78,1371,,3,,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf00240, Pf07714, Pf12179",3551,ENSG00000104365.13,IKBKB,8,B cell receptor signaling pathway; Hepatitis C; MicroRNAs in cancer; mTOR signaling pathway; Hepatitis B; HTLV-I infection; Adipocytokine signaling pathway; Th1 and Th2 cell differentiation; MAPK signaling pathway; RIG-I-like receptor signaling pathway; Epstein-Barr virus infection; Toll-like receptor signaling pathway; Pancreatic cancer; Apoptosis; Shigellosis; NOD-like receptor signaling pathway; Prostate cancer; Influenza A; Chronic myeloid leukemia; Non-alcoholic fatty liver disease (NAFLD); T cell receptor signaling pathway; Type II diabetes mellitus; Epithelial cell signaling in Helicobacter pylori infection; FoxO signaling pathway; Cytosolic DNA-sensing pathway; Chagas disease (American trypanosomiasis); Acute myeloid leukemia; Ras signaling pathway; Insulin signaling pathway; Toxoplasmosis; PI3K-Akt signaling pathway; Neurotrophin signaling pathway; Herpes simplex infection; Osteoclast differentiation; NF-kappa B signaling pathway; Insulin resistance; Antifolate resistance; Small cell lung cancer; TNF signaling pathway; Pathways in cancer; Chemokine signaling pathway,Nucleotide-binding Oligomerization Domain (NOD) pathway; Osteopontin Signaling; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; IL-1 signaling pathway; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; Leptin signaling pathway; TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway; IL17 signaling pathway; B Cell Receptor Signaling Pathway; TNF alpha Signaling Pathway; AGE/RAGE pathway; Interleukin-11 Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis; Apoptosis; EBV LMP1 signaling; Structural Pathway of Interleukin 1 (IL-1); Cardiac Hypertrophic Response; NLR Proteins; Rac1/Pak1/p38/MMP-2 pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK Signaling Pathway; MAPK  and NFkB Signalling Pathways Inhibited by Yersinia YopJ; Toll-like Receptor Signaling; T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection; RIG-I-like Receptor Signaling; Chemokine signaling pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; IL-4 Signaling Pathway; Insulin Signaling; T-Cell antigen Receptor (TCR)  Signaling Pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway,"IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); Downstream TCR signaling; NOD1/2 Signaling Pathway; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; TRAF6 mediated NF-kB activation; TICAM1, RIP1-mediated IKK complex recruitment ; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TNFR1-induced NFkappaB signaling pathway; RIP-mediated NFkB activation via ZBP1; Activated TLR4 signalling; Interleukin-1 family signaling; IRAK1 recruits IKK complex; p75NTR recruits signalling complexes; IKBKB deficiency causes SCID; IKK complex recruitment mediated by RIP1; ER-Phagosome pathway; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; NF-kB is activated and signals survival; Regulation of TNFR1 signaling; Signalling by NGF; IkBA variant leads to EDA-ID; CLEC7A (Dectin-1) signaling",144,High,1
Q9Y2K5,R3H domain-containing protein 2 OS=Homo sapiens OX=9606 GN=R3HDM2 PE=1 SV=3,0.001,7.991,2,2,3,2,976,106.9,8.85,1203,1.82,1,1,,nucleus,protein binding;RNA binding,Pf01424,22864,ENSG00000179912.20,R3HDM2,12,,,,0,High,1
Q9UK73,Protein fem-1 homolog B OS=Homo sapiens OX=9606 GN=FEM1B PE=1 SV=1,0.002,7.962,5,2,5,2,627,70.2,6.61,1781,,2,,cell death;metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,"Pf00023, Pf12796, Pf13606, Pf13637, Pf13857",10116,ENSG00000169018.5,FEM1B,15,,,Neddylation,3,High,1
Q5SGD2,Protein phosphatase 1L OS=Homo sapiens OX=9606 GN=PPM1L PE=1 SV=1,0.002,7.957,4,1,6,1,360,41,5.87,3058,,1,,metabolic process;regulation of biological process;response to stimulus,membrane,catalytic activity;metal ion binding,"Pf00481, Pf13672",151742,ENSG00000163590.13,PPM1L,3,,Amino Acid metabolism,Sphingolipid de novo biosynthesis,5,High,1
O15066,Kinesin-like protein KIF3B OS=Homo sapiens OX=9606 GN=KIF3B PE=1 SV=1,0.002,7.954,4,3,28,2,747,85.1,7.69,7961,,3,,cell organization and biogenesis;cellular component movement;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;membrane,catalytic activity;motor activity;nucleotide binding;protein binding,Pf00225,9371,ENSG00000101350.7,KIF3B,20,,,Translocation of GLUT4 to the plasma membrane; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; Intraflagellar transport; MHC class II antigen presentation,15,High,1
P54252,Ataxin-3 OS=Homo sapiens OX=9606 GN=ATXN3 PE=1 SV=5,0.002,7.933,7,2,7,2,361,41.2,4.78,2570,,2,,,,,,,,,,,,,0,High,1
Q9Y6A4,Cilia- and flagella-associated protein 20 OS=Homo sapiens OX=9606 GN=CFAP20 PE=1 SV=1,0.002,7.932,10,2,9,2,193,22.8,9.76,3723,,2,,cell organization and biogenesis;development;metabolic process;regulation of biological process,cytoplasm;cytoskeleton;nucleus,protein binding;RNA binding,Pf05018,29105,ENSG00000070761.7,C16orf80; CFAP20,16,,,,0,High,1
Q96J01,THO complex subunit 3 OS=Homo sapiens OX=9606 GN=THOC3 PE=1 SV=1,0.002,7.922,6,2,4,2,351,38.7,6.09,1813,,2,,metabolic process;transport,nucleus,protein binding;RNA binding,"Pf00400, Pf08662",84321,ENSG00000051596.9,THOC3,5,RNA transport; Spliceosome,,Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing,11,High,1
P17301,Integrin alpha-2 OS=Homo sapiens OX=9606 GN=ITGA2 PE=1 SV=1,0.002,7.92,3,3,3,3,1181,129.2,5.31,831,,3,,cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;coagulation;regulation of biological process;response to stimulus,cell surface;membrane;nucleus,metal ion binding;protein binding;receptor activity;signal transducer activity,"Pf00092, Pf01839, Pf08441, Pf13517, Pf13519",3673,,ITGA2,5,Regulation of actin cytoskeleton; Platelet activation; Pathways in cancer; Small cell lung cancer; Phagosome; ECM-receptor interaction; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Focal adhesion; PI3K-Akt signaling pathway; Dilated cardiomyopathy; Proteoglycans in cancer; Hypertrophic cardiomyopathy (HCM); Hematopoietic cell lineage,Integrin-mediated Cell Adhesion; Arrhythmogenic Right Ventricular Cardiomyopathy; Interleukin-11 Signaling Pathway; Focal Adhesion; TGF-beta Signaling Pathway,ECM proteoglycans; CHL1 interactions; Integrin cell surface interactions; Laminin interactions; MET activates PTK2 signaling; Platelet Adhesion to exposed collagen; Syndecan interactions,35,High,1
Q9UPT8,Zinc finger CCCH domain-containing protein 4 OS=Homo sapiens OX=9606 GN=ZC3H4 PE=1 SV=3,0.002,7.903,3,2,5,2,1303,140.2,6.27,1876,,2,,,,metal ion binding;RNA binding,Pf00642,23211,ENSG00000130749.9,ZC3H4,19,,,,0,High,1
Q0D2I5,Intermediate filament family orphan 1 OS=Homo sapiens OX=9606 GN=IFFO1 PE=1 SV=2,0.002,7.885,8,3,5,3,559,61.9,4.92,1422,2.13,2,1,,,structural molecule activity,Pf00038,25900,ENSG00000010295.19,IFFO1,12,,,,0,High,1
Q96RD7,Pannexin-1 OS=Homo sapiens OX=9606 GN=PANX1 PE=1 SV=4,0.002,7.883,3,1,5,1,426,48,6.01,2569,,1,,cell communication;cell organization and biogenesis;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;membrane,protein binding;transporter activity,,24145,ENSG00000110218.8,PANX1,11,NOD-like receptor signaling pathway,,Electric Transmission Across Gap Junctions; The NLRP3 inflammasome,9,High,1
Q8NFC6,Biorientation of chromosomes in cell division protein 1-like 1 OS=Homo sapiens OX=9606 GN=BOD1L1 PE=1 SV=2,0.002,7.879,1,2,4,1,3051,330.3,5.08,1808,,2,,metabolic process;response to stimulus,chromosome,,Pf05205,259282,ENSG00000038219.12,BOD1L1,4,,,,0,High,1
Q9H305,Cell death-inducing p53-target protein 1 OS=Homo sapiens OX=9606 GN=CDIP1 PE=1 SV=1,0.002,7.869,10,1,2,1,208,21.9,5.95,949,,1,,cell death;regulation of biological process;response to stimulus,endosome;membrane;nucleus;vacuole,metal ion binding;protein binding,Pf10601,29965,ENSG00000274336.2; ENSG00000089486.16,CDIP1,16; CHR_HSCHR16_3_CTG1,,,,0,High,1
P25490,Transcriptional repressor protein YY1 OS=Homo sapiens OX=9606 GN=YY1 PE=1 SV=2,0.002,7.865,5,1,1,1,414,44.7,6.25,565,,1,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,DNA binding;metal ion binding;protein binding;RNA binding,"Pf00096, Pf13465",7528,ENSG00000100811.12,YY1,14,,Sterol Regulatory Element-Binding Proteins (SREBP) signalling,TFAP2 (AP-2) family regulates transcription of growth factors and their receptors; UCH proteinases; DNA Damage Recognition in GG-NER; Activation of anterior HOX genes in hindbrain development during early embryogenesis,17,High,1
P51854,Transketolase-like protein 1 OS=Homo sapiens OX=9606 GN=TKTL1 PE=1 SV=2,0.002,7.852,14,3,11,3,596,65.3,5.86,3955,,3,,metabolic process,cytoplasm;nucleus,catalytic activity;metal ion binding,"Pf00456, Pf00676, Pf02779, Pf02780",8277,ENSG00000007350.16,TKTL1,X,Biosynthesis of amino acids; Carbon metabolism; Metabolic pathways; Pentose phosphate pathway,,,4,High,1
Q6ZUT9,DENN domain-containing protein 5B OS=Homo sapiens OX=9606 GN=DENND5B PE=1 SV=2,0.002,7.849,5,3,4,3,1274,144.9,6.73,1593,,3,,response to stimulus;transport,cytosol;membrane,protein binding;transporter activity,"Pf01477, Pf02141, Pf02759, Pf03455, Pf03456",160518,ENSG00000170456.15,DENND5B,12,,,RAB GEFs exchange GTP for GDP on RABs,4,High,1
P51857,Aldo-keto reductase family 1 member D1 OS=Homo sapiens OX=9606 GN=AKR1D1 PE=1 SV=1,0.002,7.842,3,2,53,2,326,37.4,7.5,22729,,2,,metabolic process,cytoplasm;cytosol,catalytic activity,"Pf00248, Pf02738",6718,ENSG00000122787.14,AKR1D1,7,Primary bile acid biosynthesis; Metabolic pathways; Steroid hormone biosynthesis,Metapathway biotransformation,Synthesis of bile acids and bile salts via 27-hydroxycholesterol; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Synthesis of bile acids and bile salts via 24-hydroxycholesterol,12,High,1
Q9NQT4,Exosome complex component RRP46 OS=Homo sapiens OX=9606 GN=EXOSC5 PE=1 SV=1,0.002,7.833,8,2,32,2,235,25.2,7.59,13971,,2,,defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;protein binding;RNA binding,"Pf01138, Pf03725",56915,ENSG00000077348.8,EXOSC5,19,RNA degradation,,"Major pathway of rRNA processing in the nucleolus and cytosol; mRNA decay by 3' to 5' exoribonuclease; ATF4 activates genes; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; KSRP (KHSRP) binds and destabilizes mRNA",15,High,1
Q9BXB5,Oxysterol-binding protein-related protein 10 OS=Homo sapiens OX=9606 GN=OSBPL10 PE=1 SV=2,0.002,7.832,7,2,15,1,764,83.9,8.31,7086,,2,,metabolic process;transport,cytoplasm;cytoskeleton;cytosol,transporter activity,"Pf00169, Pf01237, Pf15409",114884,ENSG00000144645.13,OSBPL10,3,,,Acyl chain remodelling of PS,5,High,1
O00168,Phospholemman OS=Homo sapiens OX=9606 GN=FXYD1 PE=1 SV=2,0.002,7.827,13,1,23,1,92,10.4,9.14,10403,,1,,regulation of biological process;transport,membrane,protein binding;transporter activity,Pf02038,5348,ENSG00000266964.5,FXYD1,19,cAMP signaling pathway,,Ion homeostasis; Ion transport by P-type ATPases,7,High,1
O75151,Lysine-specific demethylase PHF2 OS=Homo sapiens OX=9606 GN=PHF2 PE=1 SV=4,0.002,7.826,3,3,13,3,1096,120.7,9.17,4913,,3,,cell organization and biogenesis;metabolic process;regulation of biological process,chromosome;cytosol;nucleus,catalytic activity;metal ion binding;protein binding,"Pf00628, Pf02373, Pf13621",5253,ENSG00000197724.10,PHF2,9,,,HDMs demethylate histones,3,High,1
Q9UK59,Lariat debranching enzyme OS=Homo sapiens OX=9606 GN=DBR1 PE=1 SV=2,0.002,7.825,5,2,6,2,544,61.5,5.47,2193,,2,,metabolic process,nucleus,catalytic activity;metal ion binding;RNA binding,"Pf00149, Pf05011",51163,ENSG00000138231.12,DBR1,3,,,,0,High,1
Q5JSZ5,Protein PRRC2B OS=Homo sapiens OX=9606 GN=PRRC2B PE=1 SV=2,0.002,7.816,1,2,4,2,2229,242.8,8.34,1935,,2,,cell differentiation,,protein binding;RNA binding,Pf07001,84726,ENSG00000130723.18,PRRC2B,9,,,,0,High,1
Q7L1V2,Vacuolar fusion protein MON1 homolog B OS=Homo sapiens OX=9606 GN=MON1B PE=1 SV=1,0.002,7.813,6,2,5,2,547,59.2,6.29,1415,,2,,metabolic process;transport,cytoplasm,protein binding,Pf03164,22879,ENSG00000103111.14,MON1B,16,,,RAB GEFs exchange GTP for GDP on RABs,4,High,1
Q8N511,Transmembrane protein 199 OS=Homo sapiens OX=9606 GN=TMEM199 PE=1 SV=1,0.002,7.813,7,2,3,2,208,23.1,9.01,1294,,2,,cell organization and biogenesis;cellular homeostasis;response to stimulus,endoplasmic reticulum;membrane;vacuole,protein binding,Pf11712,147007,ENSG00000244045.12,TMEM199,17,,,,0,High,1
Q6WKZ4,Rab11 family-interacting protein 1 OS=Homo sapiens OX=9606 GN=RAB11FIP1 PE=1 SV=3,0.002,7.809,3,2,4,2,1283,137.1,5.43,1941,,2,,regulation of biological process;transport,cytoplasm;cytosol;endosome;membrane,protein binding,"Pf00168, Pf09457",80223,ENSG00000156675.15,RAB11FIP1,8,Endocytosis,,,1,High,1
O43826,Glucose-6-phosphate exchanger SLC37A4 OS=Homo sapiens OX=9606 GN=SLC37A4 PE=1 SV=1,0.002,7.809,5,2,2,2,429,46.3,8.62,954,,2,,metabolic process;transport,endoplasmic reticulum;membrane,transporter activity,"Pf00083, Pf07690",2542,ENSG00000281500.1,SLC37A4,11; CHR_HG2217_PATCH,Carbohydrate digestion and absorption,,Gluconeogenesis; Glycogen storage disease type Ib (SLC37A4),10,High,1
Q15048,Leucine-rich repeat-containing protein 14 OS=Homo sapiens OX=9606 GN=LRRC14 PE=1 SV=1,0.002,7.804,3,2,10,2,493,54.5,6.9,4013,,2,,regulation of biological process,cytoplasm,protein binding,,9684,ENSG00000160959.7,LRRC14,8,,,,0,High,1
Q9BYC8,"39S ribosomal protein L32, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL32 PE=1 SV=1",0.002,7.801,12,1,5,1,188,21.4,9.73,2303,,1,,cell organization and biogenesis;metabolic process,membrane;mitochondrion;ribosome,RNA binding;structural molecule activity,Pf01783,64983,ENSG00000106591.3,MRPL32,7,Ribosome,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,7,High,1
Q9NSY0,Nuclear receptor-binding protein 2 OS=Homo sapiens OX=9606 GN=NRBP2 PE=1 SV=2,0.002,7.8,3,1,7,1,501,57.8,6.49,2610,,1,,cell differentiation;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol,catalytic activity;nucleotide binding,"Pf00069, Pf07714",340371,ENSG00000185189.17,NRBP2,8,,,,0,High,1
Q9NZW5,MAGUK p55 subfamily member 6 OS=Homo sapiens OX=9606 GN=MPP6 PE=1 SV=2,0.002,7.779,6,3,6,1,540,61.1,6.18,1772,,3,,cell organization and biogenesis,membrane,protein binding,"Pf00018, Pf00595, Pf00625, Pf02828, Pf07653, Pf13180, Pf14604, Pf14685",51678,ENSG00000105926.15,MPP6,7,,,,0,High,1
Q12800,Alpha-globin transcription factor CP2 OS=Homo sapiens OX=9606 GN=TFCP2 PE=1 SV=2,0.002,7.775,4,2,9,2,502,57.2,5.8,3609,,2,,metabolic process;regulation of biological process,cytosol;nucleus,DNA binding;protein binding,Pf04516,7024,ENSG00000135457.9,TFCP2,12,,,,0,High,1
P61916,NPC intracellular cholesterol transporter 2 OS=Homo sapiens OX=9606 GN=NPC2 PE=1 SV=1,0.002,7.775,21,3,17,3,151,16.6,7.65,3243,3.18,2,2,metabolic process;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;extracellular;organelle lumen;vacuole,protein binding;transporter activity,Pf02221,10577,ENSG00000119655.10,NPC2,14,Lysosome,TYROBP Causal Network,Neutrophil degranulation; LDL clearance,9,High,1
Q567V2,Mpv17-like protein 2 OS=Homo sapiens OX=9606 GN=MPV17L2 PE=1 SV=2,0.002,7.766,9,2,2,2,206,23.2,9.25,946,,2,,regulation of biological process,membrane;mitochondrion,,Pf04117,84769,ENSG00000254858.9,MPV17L2,19,Peroxisome,,,1,High,1
Q96MH6,Transmembrane protein 68 OS=Homo sapiens OX=9606 GN=TMEM68 PE=2 SV=2,0.002,7.762,9,2,7,2,324,37.4,7.85,2547,,2,,metabolic process,membrane,catalytic activity,"Pf01553, Pf03982",137695,ENSG00000167904.14,TMEM68,8,,,,0,High,1
Q96BW1,Uracil phosphoribosyltransferase homolog OS=Homo sapiens OX=9606 GN=UPRT PE=1 SV=1,0.002,7.76,12,2,3,2,309,33.8,6.04,745,0,2,1,metabolic process;response to stimulus;transport,cytoplasm;cytosol;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00156, Pf14681",139596,ENSG00000094841.13,UPRT,X,Metabolic pathways; Pyrimidine metabolism,,,2,High,1
Q9UFW8,CGG triplet repeat-binding protein 1 OS=Homo sapiens OX=9606 GN=CGGBP1 PE=1 SV=2,0.002,7.759,16,3,7,3,167,18.8,8.95,2653,,3,,metabolic process;regulation of biological process,nucleus,DNA binding;protein binding,,8545,ENSG00000163320.10,CGGBP1,3,,,,0,High,1
Q9H4I2,Zinc fingers and homeoboxes protein 3 OS=Homo sapiens OX=9606 GN=ZHX3 PE=1 SV=3,0.002,7.75,2,2,2,1,956,104.6,6.07,993,,2,,cell differentiation;metabolic process;regulation of biological process,nucleus,DNA binding;metal ion binding;protein binding,"Pf00046, Pf11569",23051,ENSG00000174306.21,ZHX3,20,,,,0,High,1
Q8N4U5,T-complex protein 11-like protein 2 OS=Homo sapiens OX=9606 GN=TCP11L2 PE=1 SV=1,0.002,7.747,7,2,3,2,519,58.1,4.96,993,,2,,,,,Pf05794,255394,ENSG00000166046.10,TCP11L2,12,,,,0,High,1
Q9P2J3,Kelch-like protein 9 OS=Homo sapiens OX=9606 GN=KLHL9 PE=1 SV=2,0.002,7.744,3,2,6,2,617,69.4,6.35,2298,,2,,cell division;metabolic process,cytosol,catalytic activity;protein binding,"Pf00651, Pf01344, Pf07646, Pf07707, Pf13415, Pf13418, Pf13854, Pf13964",55958,ENSG00000198642.6,KLHL9,9,Ubiquitin mediated proteolysis,,Antigen processing: Ubiquitination & Proteasome degradation; Neddylation,8,High,1
Q9Y584,Mitochondrial import inner membrane translocase subunit Tim22 OS=Homo sapiens OX=9606 GN=TIMM22 PE=1 SV=2,0.003,7.725,8,1,19,1,194,20,7.59,8162,,1,,cell organization and biogenesis;transport,membrane;mitochondrion,protein binding;transporter activity,Pf02466,29928,ENSG00000278501.2; ENSG00000177370.4; ENSG00000277649.2,TIMM22,17; CHR_HSCHR17_3_CTG2; CHR_HSCHR17_2_CTG2,,,Mitochondrial protein import; Metabolism of proteins,2,High,1
Q15131,Cyclin-dependent kinase 10 OS=Homo sapiens OX=9606 GN=CDK10 PE=1 SV=1,0.003,7.719,6,2,24,1,360,41,8.84,12519,,2,,metabolic process;regulation of biological process,,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf07714, Pf14531",8558,ENSG00000185324.21,CDK10,16,,,,0,High,1
O43182,Rho GTPase-activating protein 6 OS=Homo sapiens OX=9606 GN=ARHGAP6 PE=1 SV=3,0.003,7.716,3,2,3,2,974,105.9,7.36,1510,,2,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol,enzyme regulator activity;protein binding,Pf00620,395,ENSG00000047648.21,ARHGAP6,X,,,Rho GTPase cycle,3,High,1
Q8NC96,Adaptin ear-binding coat-associated protein 1 OS=Homo sapiens OX=9606 GN=NECAP1 PE=1 SV=2,0.003,7.709,8,2,8,2,275,29.7,6.8,1954,0,2,1,cell organization and biogenesis;transport,cytosol;membrane,,Pf07933,25977,ENSG00000089818.17,NECAP1,12,,,Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis,7,High,1
Q8IWS0,PHD finger protein 6 OS=Homo sapiens OX=9606 GN=PHF6 PE=1 SV=1,0.003,7.703,5,3,11,3,365,41.3,8.68,4994,,3,,metabolic process;regulation of biological process,chromosome;nucleus,DNA binding;metal ion binding;protein binding;RNA binding,"Pf13771, Pf13832",84295,ENSG00000156531.16,PHF6,X,,Mesodermal Commitment Pathway,,1,High,1
Q8IWJ2,GRIP and coiled-coil domain-containing protein 2 OS=Homo sapiens OX=9606 GN=GCC2 PE=1 SV=4,0.003,7.692,2,2,7,2,1684,195.8,5.14,1939,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;Golgi;membrane,protein binding;structural molecule activity,"Pf00038, Pf01465, Pf04111, Pf12128",9648,ENSG00000135968.20,GCC2,2,,Deregulation of Rab and Rab Effector Genes in Bladder Cancer,Retrograde transport at the Trans-Golgi-Network,5,High,1
Q96F10,Diamine acetyltransferase 2 OS=Homo sapiens OX=9606 GN=SAT2 PE=1 SV=1,0.003,7.689,9,2,8,2,170,19.1,6.04,3272,,2,,metabolic process,cytoplasm,catalytic activity;protein binding,"Pf00583, Pf08445, Pf13508, Pf13673, Pf14542",112483,ENSG00000141504.11,SAT2,17,Arginine and proline metabolism; Metabolic pathways,,,2,High,1
Q8N8J7,Uncharacterized protein FAM241A OS=Homo sapiens OX=9606 GN=FAM241A PE=2 SV=2,0.003,7.689,20,2,6,2,132,14.6,4.7,2170,,2,,,membrane,,Pf15378,132720,ENSG00000174749.5,C4orf32; FAM241A,4,,,,0,High,1
Q8TDP1,Ribonuclease H2 subunit C OS=Homo sapiens OX=9606 GN=RNASEH2C PE=1 SV=1,0.003,7.688,13,2,8,2,164,17.8,5.03,3187,,2,,metabolic process,nucleus,,Pf08615,84153,ENSG00000172922.8,RNASEH2C,11,DNA replication,,,1,High,1
Q14149,MORC family CW-type zinc finger protein 3 OS=Homo sapiens OX=9606 GN=MORC3 PE=1 SV=3,0.003,7.687,3,2,4,2,939,107,5.6,1452,,2,,metabolic process;regulation of biological process,nucleus,metal ion binding;RNA binding,"Pf02518, Pf04111, Pf05622, Pf07496, Pf11932, Pf13589",23515,ENSG00000159256.12,MORC3,21,,Interactome of polycomb repressive complex 2 (PRC2),,1,High,1
Q6Q6R5,Cysteine-rich protein 3 OS=Homo sapiens OX=9606 GN=CRIP3 PE=2 SV=2,0.003,7.682,6,2,66,1,217,24.1,8.62,29596,,2,,,cytoplasm,metal ion binding,Pf00412,401262,ENSG00000146215.13,CRIP3,6,,,,0,High,1
A8K2U0,Alpha-2-macroglobulin-like protein 1 OS=Homo sapiens OX=9606 GN=A2ML1 PE=1 SV=3,0.003,7.678,1,2,40,1,1454,161,5.73,22372,,2,,regulation of biological process,extracellular,enzyme regulator activity,"Pf00207, Pf01835, Pf05326, Pf07677, Pf07678, Pf07703, Pf10569, Pf13249",144568,ENSG00000166535.19,A2ML1,12,,,,0,High,1
Q6QNY1,Biogenesis of lysosome-related organelles complex 1 subunit 2 OS=Homo sapiens OX=9606 GN=BLOC1S2 PE=1 SV=1,0.003,7.66,8,1,5,1,142,16,4.86,3202,,1,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus;vacuole,catalytic activity;protein binding,Pf10046,282991,ENSG00000196072.11,BLOC1S2,10,,,,0,High,1
Q8TEH3,DENN domain-containing protein 1A OS=Homo sapiens OX=9606 GN=DENND1A PE=1 SV=2,0.003,7.657,2,2,6,2,1009,110.5,6.96,2171,,2,,regulation of biological process;transport,cytosol;membrane,protein binding,"Pf02141, Pf03455, Pf03456",57706,ENSG00000119522.16,DENND1A,9,,,RAB GEFs exchange GTP for GDP on RABs,4,High,1
Q86UV5,Ubiquitin carboxyl-terminal hydrolase 48 OS=Homo sapiens OX=9606 GN=USP48 PE=1 SV=1,0.003,7.643,3,2,9,1,1035,119,6.05,3253,,2,,metabolic process,cytoplasm;cytosol;mitochondrion;nucleus,catalytic activity;protein binding,"Pf00240, Pf00443, Pf06337, Pf13423",84196,ENSG00000090686.15,USP48,1,,,Ub-specific processing proteases,4,High,1
Q9C0C4,Semaphorin-4C OS=Homo sapiens OX=9606 GN=SEMA4C PE=1 SV=2,0.003,7.638,1,2,24,1,833,92.6,7.28,10360,,2,,cell differentiation;cellular component movement;development;regulation of biological process;response to stimulus,membrane,protein binding,"Pf01403, Pf01437, Pf07679",54910,ENSG00000168758.10,SEMA4C,2,Axon guidance,,,1,High,1
Q9H1A3,Methyltransferase-like protein 9 OS=Homo sapiens OX=9606 GN=METTL9 PE=2 SV=1,0.003,7.627,10,2,4,2,318,36.5,7.36,1553,,2,,metabolic process,,catalytic activity;protein binding,"Pf05219, Pf08241, Pf08242, Pf12847, Pf13489, Pf13847",51108,ENSG00000197006.13; ENSG00000284548.1,METTL9,16; CHR_HG926_PATCH,,,,0,High,1
Q13740,CD166 antigen OS=Homo sapiens OX=9606 GN=ALCAM PE=1 SV=2,0.003,7.615,6,3,7,3,583,65.1,6.25,1460,,3,,cell growth;cellular component movement;regulation of biological process;response to stimulus,extracellular;membrane,protein binding,"Pf07679, Pf08205, Pf13895, Pf13927",214,ENSG00000170017.12,ALCAM,3,Cell adhesion molecules (CAMs),,L1CAM interactions,4,High,1
Q9BTE0,N-acetyltransferase 9 OS=Homo sapiens OX=9606 GN=NAT9 PE=1 SV=1,0.003,7.615,3,1,626,1,207,23.3,4.7,191624,,1,,,,catalytic activity;protein binding,"Pf00583, Pf08445, Pf13302, Pf13420",26151,ENSG00000109065.11,NAT9,17,,Metapathway biotransformation,,1,High,1
Q0P651,Protein ABHD18 OS=Homo sapiens OX=9606 GN=ABHD18 PE=2 SV=1,0.003,7.614,6,1,1,1,414,46.9,9.28,,3.23,,1,,extracellular,,Pf09752,80167,ENSG00000164074.14,C4orf29; ABHD18,4,,,,0,High,1
Q96JY6,PDZ and LIM domain protein 2 OS=Homo sapiens OX=9606 GN=PDLIM2 PE=1 SV=1,0.003,7.603,7,2,7,2,352,37.4,8.72,1980,,2,,,cytoplasm;cytoskeleton;nucleus,metal ion binding;protein binding,"Pf00412, Pf00595, Pf13180",64236,ENSG00000120913.23,PDLIM2,8,,,,0,High,1
Q8N5M9,Protein jagunal homolog 1 OS=Homo sapiens OX=9606 GN=JAGN1 PE=1 SV=1,0.003,7.585,7,1,3,1,183,21.1,9.73,1633,,1,,cell differentiation;cell organization and biogenesis;cellular component movement;defense response;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;membrane,protein binding,Pf07086,84522,ENSG00000171135.13,JAGN1,3,,,,0,High,1
Q9H492,Microtubule-associated proteins 1A/1B light chain 3A OS=Homo sapiens OX=9606 GN=MAP1LC3A PE=1 SV=2,0.003,7.583,12,1,13,1,121,14.3,8.68,5632,,1,,cell communication;cell organization and biogenesis;metabolic process;response to stimulus,cytoplasm;cytoskeleton;cytosol;endosome;membrane;vacuole,protein binding,"Pf02991, Pf04110",84557,ENSG00000101460.12,MAP1LC3A,20,,Nanoparticle triggered autophagic cell death; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Senescence and Autophagy in Cancer,Macroautophagy; Receptor Mediated Mitophagy; Pink/Parkin Mediated Mitophagy,8,High,1
P08575,Receptor-type tyrosine-protein phosphatase C OS=Homo sapiens OX=9606 GN=PTPRC PE=1 SV=3,0.003,7.58,2,2,3,2,1306,147.4,6.15,1063,,2,,,,,,,,,,,,,0,High,1
Q14324,"Myosin-binding protein C, fast-type OS=Homo sapiens OX=9606 GN=MYBPC2 PE=1 SV=2",0.003,7.575,1,2,34,1,1141,128,7.52,14776,0,2,1,cell organization and biogenesis;cellular component movement,cytosol,protein binding;structural molecule activity,"Pf00041, Pf00047, Pf07679, Pf13895, Pf13927",4606,ENSG00000086967.9,MYBPC2,19,,Striated Muscle Contraction,Striated Muscle Contraction,3,High,1
Q3YBM2,Transmembrane protein 176B OS=Homo sapiens OX=9606 GN=TMEM176B PE=1 SV=2,0.003,7.572,5,1,10,1,270,29,8.48,3939,,1,,cell differentiation;regulation of biological process,membrane;nucleus,,Pf04103,28959,ENSG00000106565.17,TMEM176B,7,,,,0,High,1
Q9Y5B0,RNA polymerase II subunit A C-terminal domain phosphatase OS=Homo sapiens OX=9606 GN=CTDP1 PE=1 SV=3,0.003,7.568,3,2,12,2,961,104.3,5.27,2499,,2,,cell division;metabolic process;regulation of biological process,cytoplasm;cytoskeleton;nucleus,catalytic activity;protein binding,"Pf00533, Pf03031, Pf09309, Pf12738",9150,ENSG00000060069.16,CTDP1,18,,,HIV elongation arrest and recovery; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat; TP53 Regulates Transcription of DNA Repair Genes; Tat-mediated HIV elongation arrest and recovery; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase II Pre-transcription Events; Pausing and recovery of HIV elongation; Pausing and recovery of Tat-mediated HIV elongation; Formation of HIV-1 elongation complex containing HIV-1 Tat; Formation of the Early Elongation Complex,25,High,1
Q9BRJ6,Uncharacterized protein C7orf50 OS=Homo sapiens OX=9606 GN=C7orf50 PE=1 SV=1,0.003,7.56,17,2,6,2,194,22.1,9.64,2068,,2,,,,protein binding;RNA binding,Pf10180,84310,ENSG00000146540.14,C7orf50,7,,,,0,High,1
Q9Y4H2,Insulin receptor substrate 2 OS=Homo sapiens OX=9606 GN=IRS2 PE=1 SV=2,0.003,7.557,2,2,2,2,1338,137.2,8.65,822,,2,,cell proliferation;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;protein binding;signal transducer activity,"Pf00169, Pf02174, Pf15413",8660,ENSG00000185950.8,IRS2,13,Insulin resistance; cGMP-PKG signaling pathway; Longevity regulating pathway - multiple species; Longevity regulating pathway; Non-alcoholic fatty liver disease (NAFLD); FoxO signaling pathway; Type II diabetes mellitus; MicroRNAs in cancer; Adipocytokine signaling pathway; Insulin signaling pathway; Regulation of lipolysis in adipocytes; AMPK signaling pathway,Prolactin Signaling Pathway; Adipogenesis; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Alpha 6 Beta 4 signaling pathway; Farnesoid X Receptor  Pathway; Transcription factor regulation in adipogenesis; Angiopoietin Like Protein 8 Regulatory Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Leptin Insulin Overlap; IL-4 Signaling Pathway; Insulin Signaling; EPO Receptor Signaling; Interferon type I signaling pathways,"PI3K Cascade; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Signaling by Leptin; IRS activation; Interleukin-7 signaling; PI3K/AKT activation; Signal attenuation; RET signaling; Constitutive Signaling by Aberrant PI3K in Cancer; SOS-mediated signalling; Growth hormone receptor signaling; RAF/MAP kinase cascade; Interleukin-20 family signaling",61,High,1
P57764,Gasdermin-D OS=Homo sapiens OX=9606 GN=GSDMD PE=1 SV=1,0.003,7.554,3,1,7,1,484,52.8,5.08,3754,,1,,cell communication;cell death;cell organization and biogenesis;defense response;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;membrane;organelle lumen,protein binding,Pf04598,79792,ENSG00000278718.3; ENSG00000104518.10,GSDMD,8; CHR_HSCHR8_3_CTG7,NOD-like receptor signaling pathway,,Neutrophil degranulation,4,High,1
P15529-2,Isoform B of Membrane cofactor protein OS=Homo sapiens OX=9606 GN=CD46,0.003,7.55,5,2,3,2,399,44.2,6.9,792,2.45,1,1,defense response;metabolic process;regulation of biological process;response to stimulus,cell surface;Golgi;membrane,catalytic activity;enzyme regulator activity;protein binding;receptor activity,Pf00084,4179,ENSG00000117335.19,CD46,1,,Complement and Coagulation Cascades,,1,High,1
P58166,Inhibin beta E chain OS=Homo sapiens OX=9606 GN=INHBE PE=1 SV=1,0.003,7.544,10,2,9,2,350,38.5,9.25,2711,,2,,regulation of biological process;response to stimulus,extracellular,protein binding,"Pf00019, Pf00688",83729,ENSG00000139269.2,INHBE,12,Signaling pathways regulating pluripotency of stem cells; TGF-beta signaling pathway; Cytokine-cytokine receptor interaction,,Glycoprotein hormones,7,High,1
Q8IWE5,Pleckstrin homology domain-containing family M member 2 OS=Homo sapiens OX=9606 GN=PLEKHM2 PE=1 SV=2,0.003,7.543,1,1,13,1,1019,112.7,4.93,8045,,1,,cell organization and biogenesis;regulation of biological process,cytoplasm;membrane,protein binding,"Pf00169, Pf02759",23207,ENSG00000116786.11,PLEKHM2,1,Salmonella infection,,,1,High,1
P13866,Sodium/glucose cotransporter 1 OS=Homo sapiens OX=9606 GN=SLC5A1 PE=1 SV=1,0.003,7.536,2,1,3,1,664,73.4,7.68,2404,,1,,transport,membrane,protein binding;transporter activity,Pf00474,6523,ENSG00000100170.9,SLC5A1,22,Bile secretion; Carbohydrate digestion and absorption; Mineral absorption,NRF2 pathway,Intestinal hexose absorption; Cellular hexose transport; Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM),14,High,1
P50747,Biotin--protein ligase OS=Homo sapiens OX=9606 GN=HLCS PE=1 SV=1,0.003,7.519,4,2,4,2,726,80.7,5.62,1713,,2,,cell organization and biogenesis;cell proliferation;metabolic process;response to stimulus,chromosome;cytoplasm;cytosol;mitochondrion,catalytic activity;nucleotide binding;protein binding,"Pf02237, Pf03099, Pf09825",3141,ENSG00000159267.14,HLCS,21,Biotin metabolism; Metabolic pathways,,Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency,11,High,1
Q9BSQ5,Cerebral cavernous malformations 2 protein OS=Homo sapiens OX=9606 GN=CCM2 PE=1 SV=1,0.003,7.516,6,2,5,2,444,48.8,5.54,1810,,2,,cell differentiation;cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus,cytoplasm;mitochondrion,protein binding,,83605,ENSG00000136280.15,CCM2,7,,,,0,High,1
Q9H6X2,Anthrax toxin receptor 1 OS=Homo sapiens OX=9606 GN=ANTXR1 PE=1 SV=2,0.003,7.5,3,2,6,2,564,62.7,7.61,2620,,2,,cell organization and biogenesis;regulation of biological process;response to stimulus,cell surface;membrane,metal ion binding;protein binding;receptor activity;signal transducer activity,"Pf00092, Pf05586, Pf05587, Pf13519",84168,ENSG00000169604.19,ANTXR1,2,NOD-like receptor signaling pathway,,Uptake and function of anthrax toxins,5,High,1
O94886,CSC1-like protein 1 OS=Homo sapiens OX=9606 GN=TMEM63A PE=1 SV=3,0.003,7.499,3,2,34,2,807,92.1,7.27,16597,,2,,transport,membrane;vacuole,transporter activity,"Pf02714, Pf13967, Pf14703",9725,ENSG00000196187.11,TMEM63A,1,,,Neutrophil degranulation,3,High,1
Q9H4E5,Rho-related GTP-binding protein RhoJ OS=Homo sapiens OX=9606 GN=RHOJ PE=1 SV=1,0.003,7.497,7,1,3,1,214,23.8,6.83,2428,,1,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytosol;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf08477",57381,ENSG00000126785.12,RHOJ,14,,VEGFA-VEGFR2 Signaling Pathway; Insulin Signaling,Rho GTPase cycle,5,High,1
Q96B96,Promethin OS=Homo sapiens OX=9606 GN=TMEM159 PE=1 SV=2,0.003,7.493,8,1,40,1,161,17.5,5.06,15077,,1,,,membrane,protein binding,,57146,ENSG00000011638.10; ENSG00000283997.1,TMEM159,16; CHR_HG926_PATCH,,,,0,High,1
P47929,Galectin-7 OS=Homo sapiens OX=9606 GN=LGALS7 PE=1 SV=2,0.003,7.489,26,3,5,3,136,15.1,7.62,1699,,3,,cell death,cytoplasm;extracellular;nucleus,,Pf00337,3963; 653499,ENSG00000282902.1; ENSG00000283082.1; ENSG00000205076.4; ENSG00000178934.4,LGALS7; LGALS7B,19; CHR_HG26_PATCH,,,,0,High,1
Q8IZT6,Abnormal spindle-like microcephaly-associated protein OS=Homo sapiens OX=9606 GN=ASPM PE=1 SV=2,0.003,7.487,1,2,14,1,3477,409.5,10.45,7911,,2,,cell division;cell organization and biogenesis;cellular component movement;regulation of biological process,cytoplasm;cytoskeleton;nucleus,protein binding,"Pf00307, Pf11971",259266,ENSG00000066279.17,ASPM,1,,,,0,High,1
O00418,Eukaryotic elongation factor 2 kinase OS=Homo sapiens OX=9606 GN=EEF2K PE=1 SV=2,0.003,7.476,3,2,5,2,725,82.1,5.33,1500,,2,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding,Pf02816,29904; 101930123,ENSG00000103319.11,EEF2K; LOC101930123,16,AMPK signaling pathway; Oxytocin signaling pathway,Translation Factors; AMP-activated Protein Kinase (AMPK) Signaling; BDNF-TrkB Signaling,mTORC1-mediated signalling,8,High,1
P60484,"Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Homo sapiens OX=9606 GN=PTEN PE=1 SV=1",0.003,7.472,4,2,3,2,403,47.1,6.37,1301,,2,,cell communication;cell death;cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;extracellular;membrane;mitochondrion;nucleus,catalytic activity;metal ion binding;protein binding,"Pf00102, Pf00782, Pf10409, Pf13350",5728,ENSG00000171862.10,PTEN,10,Phosphatidylinositol signaling system; PI3K-Akt signaling pathway; Pathways in cancer; Sphingolipid signaling pathway; MicroRNAs in cancer; Focal adhesion; Hepatitis B; Inositol phosphate metabolism; Prostate cancer; Insulin resistance; Endometrial cancer; p53 signaling pathway; Central carbon metabolism in cancer; EGFR tyrosine kinase inhibitor resistance; Small cell lung cancer; mTOR signaling pathway; Melanoma; Glioma; Breast cancer; FoxO signaling pathway; Tight junction,Androgen receptor signaling pathway; Regulation of Microtubule Cytoskeleton; Signaling Pathways in Glioblastoma; T-Cell Receptor and Co-stimulatory Signaling; Focal Adhesion; Signaling of Hepatocyte Growth Factor Receptor; Copper homeostasis; Pathways Affected in Adenoid Cystic Carcinoma; Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; ESC Pluripotency Pathways; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; EGF/EGFR Signaling Pathway; Insulin Signaling; Senescence and Autophagy in Cancer; DNA Damage Response (only ATM dependent),Regulation of PTEN stability and activity; Ub-specific processing proteases; Downstream TCR signaling; Negative regulation of the PI3K/AKT network; Ovarian tumor domain proteases; PTEN Loss of Function in Cancer; Regulation of PTEN localization; Synthesis of IP3 and IP4 in the cytosol; Regulation of PTEN mRNA translation; Synthesis of PIPs at the plasma membrane; TP53 Regulates Metabolic Genes,71,High,1
Q12816,Trophinin OS=Homo sapiens OX=9606 GN=TRO PE=1 SV=3,0.003,7.472,1,2,7,1,1431,143.6,9.03,4219,,2,,regulation of biological process,cytoplasm;membrane;nucleus,protein binding,Pf01454,7216,ENSG00000067445.20,TRO,X,,,,0,High,1
Q6NZ67,Mitotic-spindle organizing protein 2B OS=Homo sapiens OX=9606 GN=MZT2B PE=1 SV=1,0.003,7.465,17,2,6,2,158,16.2,10.15,2059,0,2,1,,cytoplasm;cytoskeleton;cytosol,protein binding,Pf12926,80097,ENSG00000152082.13,MZT2B,2,,,Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes,9,High,1
P27987,Inositol-trisphosphate 3-kinase B OS=Homo sapiens OX=9606 GN=ITPKB PE=1 SV=5,0.003,7.463,3,2,2,2,946,102.3,8.43,1083,,2,,cell differentiation;cell proliferation;metabolic process;regulation of biological process;response to stimulus,cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding,Pf03770,3707,ENSG00000143772.9,ITPKB,1,Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Calcium signaling pathway,,Synthesis of IP3 and IP4 in the cytosol,7,High,1
Q14653,Interferon regulatory factor 3 OS=Homo sapiens OX=9606 GN=IRF3 PE=1 SV=1,0.003,7.456,9,2,5,2,427,47.2,5.34,1192,,2,,cell death;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,DNA binding;protein binding,"Pf00605, Pf10401",3661,ENSG00000126456.15,IRF3,19,Hepatitis C; Pertussis; Viral carcinogenesis; Influenza A; Toll-like receptor signaling pathway; Hepatitis B; Cytosolic DNA-sensing pathway; Epstein-Barr virus infection; RIG-I-like receptor signaling pathway; NOD-like receptor signaling pathway; Herpes simplex infection; Measles,Regulation of toll-like receptor signaling pathway; Apoptosis; TLR4 Signaling and Tolerance; Toll-like Receptor Signaling; RIG-I-like Receptor Signaling; White fat cell differentiation; Toll-like receptor signaling pathway,IRF3 mediated activation of type 1 IFN; TICAM1-dependent activation of IRF3/IRF7; ISG15 antiviral mechanism; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production; Interferon gamma signaling; IRF3-mediated induction of type I IFN; TRAF6 mediated IRF7 activation; Regulation of innate immune responses to cytosolic DNA; TRAF3-dependent IRF activation pathway; Factors involved in megakaryocyte development and platelet production; Activated TLR4 signalling; Interferon alpha/beta signaling; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; Negative regulators of DDX58/IFIH1 signaling,48,High,1
Q16570,Atypical chemokine receptor 1 OS=Homo sapiens OX=9606 GN=ACKR1 PE=1 SV=3,0.003,7.452,7,1,10,1,336,35.5,6.58,4548,,1,,defense response;regulation of biological process;response to stimulus,endosome;membrane,protein binding;receptor activity;signal transducer activity,,2532,ENSG00000213088.9,DARC; ACKR1,1,Malaria,"GPCRs, Other; Peptide GPCRs",Peptide ligand-binding receptors,8,High,1
O75037,Kinesin-like protein KIF21B OS=Homo sapiens OX=9606 GN=KIF21B PE=1 SV=2,0.003,7.444,1,2,15,1,1637,182.5,7.08,5614,,2,,cellular component movement;metabolic process,cytoplasm;cytoskeleton,catalytic activity;motor activity;nucleotide binding;protein binding,"Pf00225, Pf00400, Pf04111, Pf14988",23046,ENSG00000116852.14,KIF21B,1,,,COPI-dependent Golgi-to-ER retrograde traffic; Kinesins,8,High,1
Q9ULX7,Carbonic anhydrase 14 OS=Homo sapiens OX=9606 GN=CA14 PE=1 SV=1,0.003,7.439,7,2,14,2,337,37.6,6.37,2552,,2,,transport,membrane,catalytic activity;metal ion binding,Pf00194,23632,ENSG00000118298.10,CA14,1,Nitrogen metabolism,,Reversible hydration of carbon dioxide,3,High,1
O43715,TP53-regulated inhibitor of apoptosis 1 OS=Homo sapiens OX=9606 GN=TRIAP1 PE=1 SV=1,0.003,7.432,18,1,2,1,76,8.8,5.48,1178,,1,,cell death;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport,cytoplasm;mitochondrion,protein binding;transporter activity,Pf05254,51499,ENSG00000170855.3,TRIAP1,12,,,TP53 Regulates Transcription of Genes Involved in Cytochrome C Release,6,High,1
Q6ZNL6,"FYVE, RhoGEF and PH domain-containing protein 5 OS=Homo sapiens OX=9606 GN=FGD5 PE=1 SV=3",0.003,7.43,1,2,6,2,1462,159.8,5.01,2775,,2,,cell differentiation;cell organization and biogenesis;regulation of biological process,cytoplasm;cytoskeleton;endoplasmic reticulum;endosome;Golgi;membrane,catalytic activity;DNA binding;metal ion binding;protein binding,"Pf00169, Pf00621, Pf01363, Pf03574",152273,ENSG00000154783.11,FGD5,3,,,,0,High,1
O43156,TELO2-interacting protein 1 homolog OS=Homo sapiens OX=9606 GN=TTI1 PE=1 SV=3,0.003,7.428,3,2,4,2,1089,122,5.97,1718,,2,,regulation of biological process,cytoplasm,protein binding,,9675,ENSG00000101407.12,TTI1,20,mTOR signaling pathway,,,1,High,1
P49366,Deoxyhypusine synthase OS=Homo sapiens OX=9606 GN=DHPS PE=1 SV=1,0.003,7.425,8,2,6,2,369,40.9,5.36,1670,,2,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol,catalytic activity;protein binding,Pf01916,1725,ENSG00000095059.15,DHPS,19,,,Hypusine synthesis from eIF5A-lysine,4,High,1
Q9ULC0,Endomucin OS=Homo sapiens OX=9606 GN=EMCN PE=1 SV=2,0.003,7.424,8,2,7,2,261,27.4,7.94,1480,3.86,1,1,regulation of biological process,extracellular;membrane,,Pf07010,51705,ENSG00000164035.9,EMCN,4,,,,0,High,1
O95382,Mitogen-activated protein kinase kinase kinase 6 OS=Homo sapiens OX=9606 GN=MAP3K6 PE=1 SV=3,0.003,7.423,3,2,4,2,1288,142.5,7.11,1275,,2,,metabolic process;regulation of biological process;response to stimulus,,catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf07714, Pf13281",9064,ENSG00000142733.14,MAP3K6,1,MAPK signaling pathway,MAPK Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; Insulin Signaling,,4,High,1
P52435,DNA-directed RNA polymerase II subunit RPB11-a OS=Homo sapiens OX=9606 GN=POLR2J PE=1 SV=1,0.003,7.419,13,2,7,2,117,13.3,5.86,1899,,2,,metabolic process;regulation of biological process;response to stimulus,nucleus,catalytic activity;DNA binding;protein binding,Pf13656,5439,ENSG00000005075.15,POLR2J,7,Pyrimidine metabolism; Huntington's disease; RNA polymerase; Metabolic pathways; Purine metabolism; Epstein-Barr virus infection,Eukaryotic Transcription Initiation,Signaling by FGFR2 IIIa TM; RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Formation of HIV-1 elongation complex containing HIV-1 Tat; MicroRNA (miRNA) biogenesis; Formation of the HIV-1 Early Elongation Complex; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; TP53 Regulates Transcription of DNA Repair Genes; Transcriptional regulation by small RNAs; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; RNA Polymerase II HIV Promoter Escape; Formation of HIV elongation complex in the absence of HIV Tat; Transcriptional regulation of pluripotent stem cells; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; Formation of TC-NER Pre-Incision Complex; Pausing and recovery of HIV elongation; RNA Polymerase II Promoter Escape; HIV elongation arrest and recovery; RNA Pol II CTD phosphorylation and interaction with CE; Viral Messenger RNA Synthesis; RNA Polymerase II Transcription Initiation; mRNA Capping; Dual incision in TC-NER; PIWI-interacting RNA (piRNA) biogenesis; Pausing and recovery of Tat-mediated HIV elongation; Formation of the Early Elongation Complex,75,High,1
O75127,"Pentatricopeptide repeat-containing protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=PTCD1 PE=1 SV=2",0.003,7.417,3,2,6,2,700,78.8,8.59,2252,,2,,metabolic process,mitochondrion;organelle lumen,RNA binding,"Pf01535, Pf13041, Pf13812",26024,ENSG00000106246.17,PTCD1,7,,,,0,High,1
O95400,CD2 antigen cytoplasmic tail-binding protein 2 OS=Homo sapiens OX=9606 GN=CD2BP2 PE=1 SV=1,0.003,7.413,3,2,10,2,341,37.6,4.61,3951,,2,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,protein binding,Pf02213,10421,ENSG00000169217.8,CD2BP2,16,,mRNA Processing,mRNA Splicing - Major Pathway,5,High,1
O60244,Mediator of RNA polymerase II transcription subunit 14 OS=Homo sapiens OX=9606 GN=MED14 PE=1 SV=2,0.003,7.394,4,3,5,3,1454,160.5,8.73,1229,,3,,metabolic process;regulation of biological process;response to stimulus,membrane;nucleus,protein binding;receptor activity,"Pf08638, Pf15449",9282,ENSG00000180182.10,MED14,X,Thyroid hormone signaling pathway,,Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway,10,High,1
Q03167,Transforming growth factor beta receptor type 3 OS=Homo sapiens OX=9606 GN=TGFBR3 PE=1 SV=3,0.003,7.388,3,2,7,2,851,93.4,5.71,2440,,2,,cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cell surface;cytoplasm;extracellular;membrane,catalytic activity;protein binding;receptor activity;signal transducer activity,Pf00100,7049,ENSG00000069702.10,TGFBR3,1,,Extracellular vesicle-mediated signaling in recipient cells; TGF-beta Signaling Pathway; Hypothesized Pathways in Pathogenesis of Cardiovascular Disease; TGF-beta Receptor Signaling,,4,High,1
Q6UUV9,CREB-regulated transcription coactivator 1 OS=Homo sapiens OX=9606 GN=CRTC1 PE=1 SV=2,0.003,7.379,7,2,6,2,634,67.3,6.05,2514,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,protein binding,"Pf12884, Pf12885, Pf12886",23373,ENSG00000105662.15,CRTC1,19,HTLV-I infection,Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Mesodermal Commitment Pathway,"Transcriptional activation of mitochondrial biogenesis; BMAL1:CLOCK,NPAS2 activates circadian gene expression",8,High,1
Q9UIL1,Short coiled-coil protein OS=Homo sapiens OX=9606 GN=SCOC PE=1 SV=2,0.003,7.376,11,1,14,1,159,18,8.85,4682,,1,,metabolic process;regulation of biological process,cytoplasm;cytosol;endosome;Golgi;membrane,protein binding,"Pf04111, Pf10211, Pf10224",60592,ENSG00000153130.17,SCOC,4,,,Retrograde transport at the Trans-Golgi-Network,4,High,1
P18615,Negative elongation factor E OS=Homo sapiens OX=9606 GN=NELFE PE=1 SV=3,0.003,7.374,9,2,2,2,380,43.2,9.33,1029,,2,,metabolic process;regulation of biological process,membrane;nucleus,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259, Pf14605",7936,ENSG00000204356.13; ENSG00000206268.11; ENSG00000233801.9; ENSG00000206357.11; ENSG00000231044.10; ENSG00000229363.9,NELFE; RDBP,6; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_MCF_CTG1,,Initiation of transcription and translation elongation at the HIV-1 LTR,HIV elongation arrest and recovery; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat; TP53 Regulates Transcription of DNA Repair Genes; Tat-mediated HIV elongation arrest and recovery; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase II Pre-transcription Events; Pausing and recovery of HIV elongation; Pausing and recovery of Tat-mediated HIV elongation; Formation of HIV-1 elongation complex containing HIV-1 Tat; Formation of the Early Elongation Complex,26,High,1
O60476,"Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB OS=Homo sapiens OX=9606 GN=MAN1A2 PE=1 SV=1",0.003,7.364,5,2,2,2,641,73,7.61,729,,2,,metabolic process,endoplasmic reticulum;Golgi;membrane,catalytic activity;metal ion binding,Pf01532,10905,ENSG00000198162.12,MAN1A2,1,N-Glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum,,"Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2; Intra-Golgi traffic",13,High,1
P53365,Arfaptin-2 OS=Homo sapiens OX=9606 GN=ARFIP2 PE=1 SV=1,0.003,7.362,13,2,3,2,341,37.8,6.04,974,,2,,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,nucleotide binding;protein binding,"Pf03114, Pf06456",23647,ENSG00000132254.12,ARFIP2,11,,,Retrograde transport at the Trans-Golgi-Network,4,High,1
Q9H902,Receptor expression-enhancing protein 1 OS=Homo sapiens OX=9606 GN=REEP1 PE=1 SV=1,0.003,7.361,13,2,3,2,201,22.2,9.5,1216,,2,,cell organization and biogenesis;regulation of biological process,cytoplasm;endoplasmic reticulum;membrane;mitochondrion,protein binding,Pf03134,65055,ENSG00000068615.17,REEP1,2,,,Olfactory Signaling Pathway; GPCR downstream signalling,4,High,1
Q96FV9,THO complex subunit 1 OS=Homo sapiens OX=9606 GN=THOC1 PE=1 SV=1,0.003,7.352,3,2,6,2,657,75.6,4.98,2129,,2,,cell death;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus,DNA binding;protein binding;RNA binding,"Pf00531, Pf11957",9984,ENSG00000079134.11,THOC1,18,RNA transport; Spliceosome,,Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing,11,High,1
Q8IZW8,Tensin-4 OS=Homo sapiens OX=9606 GN=TNS4 PE=1 SV=3,0.003,7.351,2,2,26,1,715,76.7,7.34,12678,,2,,cell death,cytoplasm;cytoskeleton;cytosol,protein binding,"Pf00017, Pf08416",84951,ENSG00000131746.12,TNS4,17,,,MET interacts with TNS proteins,5,High,1
Q9HCF6,Transient receptor potential cation channel subfamily M member 3 OS=Homo sapiens OX=9606 GN=TRPM3 PE=2 SV=4,0.003,7.345,1,1,43,1,1732,197.4,7.15,24556,,1,,cell organization and biogenesis;response to stimulus;transport,membrane,transporter activity,"Pf00520, Pf12072",80036,,TRPM3,9,,,TRP channels,4,High,1
O75077,Disintegrin and metalloproteinase domain-containing protein 23 OS=Homo sapiens OX=9606 GN=ADAM23 PE=1 SV=1,0.003,7.338,2,1,6,1,832,91.9,7.64,3684,,1,,metabolic process,extracellular;membrane,catalytic activity;protein binding,"Pf00200, Pf01421, Pf01562, Pf08516, Pf13574, Pf13582, Pf13688",8745,ENSG00000114948.12,ADAM23,2,,,LGI-ADAM interactions,2,High,1
Q9NUS5,AP-5 complex subunit sigma-1 OS=Homo sapiens OX=9606 GN=AP5S1 PE=1 SV=1,0.003,7.329,5,1,5,1,200,22.5,6.87,2620,,1,,metabolic process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane;vacuole,protein binding,Pf15001,55317,ENSG00000125843.10,AP5S1,20,,,,0,High,1
Q4ZIN3,Membralin OS=Homo sapiens OX=9606 GN=TMEM259 PE=1 SV=1,0.003,7.326,3,2,3,2,620,67.8,5.3,1349,,2,,regulation of biological process;response to stimulus,endoplasmic reticulum;membrane,,Pf09746,91304,ENSG00000182087.12,C19orf6; TMEM259,19,,,,0,High,1
Q9BYB4,Guanine nucleotide-binding protein subunit beta-like protein 1 OS=Homo sapiens OX=9606 GN=GNB1L PE=1 SV=2,0.003,7.323,6,2,6,2,327,35.6,7.97,2067,,2,,regulation of biological process;response to stimulus,cytoplasm,protein binding,Pf00400,54584,ENSG00000185838.13,GNB1L,22,,,,0,High,1
Q96JD6,"1,5-anhydro-D-fructose reductase OS=Homo sapiens OX=9606 GN=AKR1E2 PE=1 SV=2",0.003,7.317,3,1,50,1,320,36.6,7.49,27724,,1,,metabolic process,cytoplasm;cytosol;Golgi,catalytic activity,Pf00248,83592,ENSG00000165568.17,AKR1E2,10,,,,0,High,1
O60234,Glia maturation factor gamma OS=Homo sapiens OX=9606 GN=GMFG PE=1 SV=1,0.003,7.313,15,2,29,1,142,16.8,5.26,10800,,2,,metabolic process;regulation of biological process;transport,extracellular;organelle lumen,enzyme regulator activity;protein binding,Pf00241,9535,ENSG00000130755.12,GMFG,19,,,Neutrophil degranulation,3,High,1
Q53GL7,Protein mono-ADP-ribosyltransferase PARP10 OS=Homo sapiens OX=9606 GN=PARP10 PE=1 SV=2,0.003,7.311,4,3,4,3,1025,109.9,4.97,1094,,3,,metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,Pf00644,84875,ENSG00000178685.13,PARP10,8,,,Nicotinamide salvaging,5,High,1
Q8IUH5,Palmitoyltransferase ZDHHC17 OS=Homo sapiens OX=9606 GN=ZDHHC17 PE=1 SV=2,0.003,7.306,2,1,2,1,632,72.6,7.5,1005,,1,,metabolic process;regulation of biological process;response to stimulus;transport,cytosol;Golgi;membrane,catalytic activity;metal ion binding;protein binding;signal transducer activity;transporter activity,"Pf00023, Pf01529, Pf12796, Pf13606, Pf13637, Pf13857",23390,ENSG00000186908.14,ZDHHC17,12,,,,0,High,1
P63272,Transcription elongation factor SPT4 OS=Homo sapiens OX=9606 GN=SUPT4H1 PE=1 SV=1,0.003,7.302,15,2,3,2,117,13.2,8.06,1201,,2,,cell organization and biogenesis;metabolic process;regulation of biological process,nucleus,metal ion binding;protein binding;RNA binding,Pf06093,6827,ENSG00000213246.6,SUPT4H1,17,,Initiation of transcription and translation elongation at the HIV-1 LTR,HIV elongation arrest and recovery; Formation of the HIV-1 Early Elongation Complex; RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; TP53 Regulates Transcription of DNA Repair Genes; Tat-mediated HIV elongation arrest and recovery; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase II Pre-transcription Events; Pausing and recovery of HIV elongation; Pausing and recovery of Tat-mediated HIV elongation; Formation of HIV-1 elongation complex containing HIV-1 Tat; Formation of the Early Elongation Complex,27,High,1
Q53HI1,Protein unc-50 homolog OS=Homo sapiens OX=9606 GN=UNC50 PE=1 SV=2,0.003,7.301,8,1,4,1,259,30.4,9.47,1863,,1,,transport,Golgi;membrane;nucleus,RNA binding,Pf05216,25972,ENSG00000115446.11,UNC50,2,,,,0,High,1
Q9BV47,Dual specificity protein phosphatase 26 OS=Homo sapiens OX=9606 GN=DUSP26 PE=1 SV=1,0.003,7.285,6,1,3,1,211,23.9,9.61,,8.54,,1,metabolic process;regulation of biological process,cytoplasm;Golgi;mitochondrion;nucleus,catalytic activity;protein binding,"Pf00102, Pf00782",78986,ENSG00000133878.8,DUSP26,8,,,,0,High,1
P10588,Nuclear receptor subfamily 2 group F member 6 OS=Homo sapiens OX=9606 GN=NR2F6 PE=1 SV=2,0.003,7.277,7,2,7,2,404,43,7.78,2299,,2,,metabolic process;regulation of biological process;response to stimulus,nucleus,DNA binding;metal ion binding;protein binding;receptor activity;signal transducer activity,"Pf00104, Pf00105",2063,ENSG00000160113.5,NR2F6,19,,Nuclear Receptors; IL-6 signaling pathway,Nuclear Receptor transcription pathway,6,High,1
O75911,Short-chain dehydrogenase/reductase 3 OS=Homo sapiens OX=9606 GN=DHRS3 PE=1 SV=2,0.003,7.276,9,2,3,2,302,33.5,8.84,1180,,2,,metabolic process;regulation of biological process,membrane,catalytic activity;nucleotide binding,"Pf00106, Pf01370, Pf02719, Pf08659, Pf13561",9249,ENSG00000162496.8,DHRS3,1,Retinol metabolism; Metabolic pathways,Vitamin A and Carotenoid Metabolism,Signaling by GPCR; RA biosynthesis pathway; The retinoid cycle in cones (daylight vision),10,High,1
Q9HAS0,Protein Njmu-R1 OS=Homo sapiens OX=9606 GN=C17orf75 PE=1 SV=2,0.003,7.275,3,1,6,1,396,44.6,5.03,2912,,1,,,,,Pf15053,64149,ENSG00000108666.9,C17orf75,17,,,,0,High,1
O00425,Insulin-like growth factor 2 mRNA-binding protein 3 OS=Homo sapiens OX=9606 GN=IGF2BP3 PE=1 SV=2,0.003,7.269,5,2,21,1,579,63.7,8.87,8211,,2,,metabolic process;regulation of biological process;transport,cytoplasm;cytosol;membrane;nucleus,protein binding;RNA binding;translation regulator activity,"Pf00013, Pf00076, Pf13014, Pf13893, Pf14259, Pf14611",10643,ENSG00000136231.13,IGF2BP3,7,,,Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA,2,High,1
P19256,Lymphocyte function-associated antigen 3 OS=Homo sapiens OX=9606 GN=CD58 PE=1 SV=1,0.002,7.262,4,1,10,1,250,28.1,6.76,6369,,1,,cellular component movement;regulation of biological process;response to stimulus;transport,cell surface;membrane,protein binding,,965,ENSG00000116815.15,CD58,1,Cell adhesion molecules (CAMs); Epstein-Barr virus infection,,Neutrophil degranulation; Cell surface interactions at the vascular wall,7,High,1
Q9NWS0,PIH1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PIH1D1 PE=1 SV=1,0.002,7.259,10,2,6,2,290,32.3,5.14,1474,0,1,1,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;nucleus,DNA binding;protein binding,Pf08190,55011,ENSG00000104872.10,PIH1D1,19,,,,0,High,1
Q02817,Mucin-2 OS=Homo sapiens OX=9606 GN=MUC2 PE=1 SV=2,0.002,7.242,0,2,20,2,5179,540,5.8,11027,,2,,metabolic process;regulation of biological process;response to stimulus,extracellular;membrane;organelle lumen,protein binding,"Pf00007, Pf00094, Pf01826, Pf03045, Pf08742, Pf13330",4583,,MUC2,11,Amoebiasis; Vibrio cholerae infection,,Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC); Dectin-2 family; Defective GALNT12 causes colorectal cancer 1 (CRCS1); Termination of O-glycan biosynthesis; Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS),17,High,1
Q9UPW5,Cytosolic carboxypeptidase 1 OS=Homo sapiens OX=9606 GN=AGTPBP1 PE=1 SV=3,0.002,7.242,1,2,6,2,1226,138.4,6.15,2350,,2,,cell differentiation;cell organization and biogenesis;metabolic process,cytoplasm;cytosol;mitochondrion;nucleus,catalytic activity;metal ion binding;protein binding,"Pf00246, Pf04952",23287,ENSG00000135049.15,AGTPBP1,9,,,Carboxyterminal post-translational modifications of tubulin,3,High,1
Q13637,Ras-related protein Rab-32 OS=Homo sapiens OX=9606 GN=RAB32 PE=1 SV=3,0.002,7.24,9,2,5,2,225,25,6.54,1939,,2,,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytosol;endoplasmic reticulum;endosome;Golgi;membrane;mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf04670, Pf08477, Pf13401",10981,ENSG00000118508.4,RAB32,6,,,RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation,7,High,1
O95470,Sphingosine-1-phosphate lyase 1 OS=Homo sapiens OX=9606 GN=SGPL1 PE=1 SV=3,0.002,7.238,7,3,7,3,568,63.5,9.16,1777,,3,,cell death;cell differentiation;cellular component movement;metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;membrane,catalytic activity;protein binding,"Pf00155, Pf00266, Pf00282, Pf01053, Pf05889",8879,ENSG00000166224.16,SGPL1,10,Sphingolipid signaling pathway; Metabolic pathways; Sphingolipid metabolism,Kennedy pathway,Sphingolipid de novo biosynthesis,8,High,1
Q6NXT1,Ankyrin repeat domain-containing protein 54 OS=Homo sapiens OX=9606 GN=ANKRD54 PE=1 SV=2,0.002,7.23,8,2,2,2,300,32.5,6.28,685,,2,,regulation of biological process;transport,cytoplasm;nucleus,enzyme regulator activity;protein binding,"Pf00023, Pf12796, Pf13606, Pf13637, Pf13857",129138,ENSG00000100124.14,ANKRD54,22,,,,0,High,1
O95147,Dual specificity protein phosphatase 14 OS=Homo sapiens OX=9606 GN=DUSP14 PE=1 SV=1,0.002,7.228,11,1,1,1,198,22.2,9.57,407,,1,,metabolic process;regulation of biological process,,catalytic activity;protein binding;RNA binding,"Pf00102, Pf00782",11072,ENSG00000275932.2; ENSG00000276023.4,DUSP14,17; CHR_HSCHR17_7_CTG4,,Hypertrophy Model,,1,High,1
P04070,Vitamin K-dependent protein C OS=Homo sapiens OX=9606 GN=PROC PE=1 SV=1,0.002,7.224,7,2,5,2,461,52,6.28,1587,,2,,cellular component movement;coagulation;metabolic process;regulation of biological process;transport,endoplasmic reticulum;extracellular;Golgi;organelle lumen,catalytic activity;metal ion binding;protein binding,"Pf00008, Pf00089, Pf00594, Pf14670",5624,ENSG00000115718.17,PROC,2,Complement and coagulation cascades,Complement and Coagulation Cascades,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus; Common Pathway of Fibrin Clot Formation; Cell surface interactions at the vascular wall; Intrinsic Pathway of Fibrin Clot Formation; Removal of aminoterminal propeptides from gamma-carboxylated proteins; Gamma-carboxylation of protein precursors,16,High,1
Q96HP4,Oxidoreductase NAD-binding domain-containing protein 1 OS=Homo sapiens OX=9606 GN=OXNAD1 PE=1 SV=1,0.002,7.206,9,2,5,2,312,34.8,8.37,1683,,2,,metabolic process,mitochondrion,catalytic activity,"Pf00175, Pf08030",92106,ENSG00000154814.13,OXNAD1,3,,,,0,High,1
Q8NHG7,Small VCP/p97-interacting protein OS=Homo sapiens OX=9606 GN=SVIP PE=1 SV=1,0.002,7.195,23,2,4,2,77,8.4,8.91,1772,,2,,regulation of biological process;transport,endoplasmic reticulum;Golgi;membrane,protein binding,,258010,ENSG00000198168.8,SVIP,11,Protein processing in endoplasmic reticulum,,Neutrophil degranulation,4,High,1
Q6ZP80,Transmembrane protein 182 OS=Homo sapiens OX=9606 GN=TMEM182 PE=1 SV=2,0.002,7.183,4,1,87,1,229,25.9,6.93,41126,,1,,,membrane,protein binding,Pf13903,130827,ENSG00000170417.15,TMEM182,2,,,,0,High,1
Q8N912,Nutritionally-regulated adipose and cardiac enriched protein homolog OS=Homo sapiens OX=9606 GN=NRAC PE=2 SV=1,0.002,7.178,9,1,10,1,160,18,11.21,5262,,1,,,membrane,,Pf15555,400258,ENSG00000184601.10; ENSG00000274126.4,C14orf180,14; CHR_HSCHR14_2_CTG1,,,,0,High,1
Q4ZHG4,Fibronectin type III domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FNDC1 PE=2 SV=4,0.002,7.164,2,2,4,2,1894,205.4,9.32,1628,,2,,,extracellular,protein binding,Pf00041,84624,ENSG00000164694.16,FNDC1,6,,,,0,High,1
A0A075B6R2,Immunoglobulin heavy variable 4-4 OS=Homo sapiens OX=9606 GN=IGHV4-4 PE=3 SV=2,0.002,7.163,24,2,13,2,117,12.8,9.6,4713,,2,,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,protein binding,,28401,ENSG00000276775.1; ENSG00000282223.1,IGHV4-4,14; CHR_HSCHR14_3_CTG1,,,,0,High,1
Q9Y672,"Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase OS=Homo sapiens OX=9606 GN=ALG6 PE=1 SV=2",0.002,7.154,3,1,6,1,507,58.1,8.46,2679,,1,,metabolic process,endoplasmic reticulum;membrane,catalytic activity,Pf03155,29929,ENSG00000088035.15,ALG6,1,N-Glycan biosynthesis; Metabolic pathways,"GPCRs, Other",,3,High,1
P24311,"Cytochrome c oxidase subunit 7B, mitochondrial OS=Homo sapiens OX=9606 GN=COX7B PE=1 SV=2",0.002,7.154,20,1,4,1,80,9.2,10.27,1954,,1,,metabolic process;transport,membrane;mitochondrion,catalytic activity;transporter activity,Pf05392,1349,ENSG00000131174.4,COX7B,X,Metabolic pathways; Parkinson's disease; Oxidative phosphorylation; Cardiac muscle contraction; Non-alcoholic fatty liver disease (NAFLD); Alzheimer's disease; Huntington's disease,Electron Transport Chain,TP53 Regulates Metabolic Genes; Respiratory electron transport,17,High,1
Q13522,Protein phosphatase 1 regulatory subunit 1A OS=Homo sapiens OX=9606 GN=PPP1R1A PE=1 SV=2,0.002,7.152,12,1,7,1,171,19,6.3,3981,,1,,metabolic process;regulation of biological process;response to stimulus,cytoplasm,enzyme regulator activity;protein binding,Pf05395,5502,,PPP1R1A,12,Long-term potentiation; Adrenergic signaling in cardiomyocytes,Common Pathways Underlying Drug Addiction,,3,High,1
O94964,Protein SOGA1 OS=Homo sapiens OX=9606 GN=SOGA1 PE=1 SV=2,0.002,7.148,1,2,17,1,1423,159.7,6.46,5574,,2,,regulation of biological process;response to stimulus,extracellular,,"Pf11365, Pf14818",140710,,SOGA1,20,,,,0,High,1
Q15012,Lysosomal-associated transmembrane protein 4A OS=Homo sapiens OX=9606 GN=LAPTM4A PE=1 SV=1,0.002,7.146,12,1,3,1,233,26.8,6.49,1686,,1,,transport,Golgi;membrane,protein binding,Pf03821,9741,ENSG00000068697.6,LAPTM4A,2,Lysosome,,,1,High,1
Q8IYM9,E3 ubiquitin-protein ligase TRIM22 OS=Homo sapiens OX=9606 GN=TRIM22 PE=1 SV=1,0.002,7.143,6,2,4,2,498,56.9,7.72,1502,,2,,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus;ribosome,catalytic activity;metal ion binding;protein binding;structural molecule activity,Pf00380,10346,ENSG00000132274.15,TRIM22,11,,,Interferon gamma signaling,4,High,1
Q9Y2H6,Fibronectin type-III domain-containing protein 3A OS=Homo sapiens OX=9606 GN=FNDC3A PE=1 SV=4,0.002,7.126,2,1,3,1,1198,131.8,6.71,1571,,1,,,cytosol;Golgi;membrane,protein binding;RNA binding,Pf00041,22862,ENSG00000102531.16,FNDC3A,13,,,,0,High,1
Q7RTS9,Dymeclin OS=Homo sapiens OX=9606 GN=DYM PE=1 SV=1,0.002,7.123,3,2,8,2,669,75.9,5.86,3316,,2,,cell organization and biogenesis,cytoplasm;Golgi;membrane,protein binding,"Pf09742, Pf12722",54808,ENSG00000141627.13,DYM,18,,,,0,High,1
Q9BTX7,Alpha-tocopherol transfer protein-like OS=Homo sapiens OX=9606 GN=TTPAL PE=1 SV=2,0.002,7.118,8,2,5,2,342,38.5,6.44,1323,,2,,transport,membrane,transporter activity,"Pf00650, Pf03765, Pf13716",79183,ENSG00000124120.10,TTPAL,20,,,,0,High,1
Q9Y244,Proteasome maturation protein OS=Homo sapiens OX=9606 GN=POMP PE=1 SV=1,0.002,7.116,33,3,5,3,141,15.8,5.11,933,,3,,cell organization and biogenesis,cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus,protein binding,Pf05348,51371,ENSG00000132963.7,POMP,13,Proteasome,,,1,High,1
Q9UKA2,F-box/LRR-repeat protein 4 OS=Homo sapiens OX=9606 GN=FBXL4 PE=1 SV=2,0.002,7.115,3,2,3,2,621,70.1,6.52,1691,,2,,metabolic process,cytoplasm;cytosol;mitochondrion;nucleus,catalytic activity;protein binding,"Pf00646, Pf12937",26235,ENSG00000112234.8,FBXL4,6,,,Antigen processing: Ubiquitination & Proteasome degradation; Neddylation,7,High,1
Q96QF0,Rab-3A-interacting protein OS=Homo sapiens OX=9606 GN=RAB3IP PE=1 SV=1,0.002,7.113,7,2,4,2,476,53,5.97,1453,,2,,cell organization and biogenesis;metabolic process;transport,cytoplasm;cytoskeleton;cytosol;nucleus,catalytic activity;motor activity;protein binding,"Pf01576, Pf03962, Pf04111, Pf05103, Pf06428, Pf13514",117177,ENSG00000127328.21,RAB3IP,12,,,BBSome-mediated cargo-targeting to cilium; VxPx cargo-targeting to cilium; RAB GEFs exchange GTP for GDP on RABs; Anchoring of the basal body to the plasma membrane,10,High,1
Q2M1P5,Kinesin-like protein KIF7 OS=Homo sapiens OX=9606 GN=KIF7 PE=1 SV=2,0.002,7.112,3,2,5,1,1343,150.5,6.79,1286,,2,,cellular component movement;metabolic process;regulation of biological process,cytoplasm;cytoskeleton,catalytic activity;motor activity;nucleotide binding;protein binding,"Pf00225, Pf04111",374654,ENSG00000166813.14,KIF7,15,Hedgehog signaling pathway,Hedgehog Signaling Pathway,Hedgehog 'on' state; Hedgehog 'off' state,6,High,1
Q8N9B5,Junction-mediating and -regulatory protein OS=Homo sapiens OX=9606 GN=JMY PE=1 SV=2,0.002,7.106,3,2,3,2,988,111.4,6.18,1337,,2,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;nucleus,protein binding,,133746,ENSG00000152409.8,JMY,5,,,Regulation of TP53 Activity through Methylation,6,High,1
Q7Z7E8,Ubiquitin-conjugating enzyme E2 Q1 OS=Homo sapiens OX=9606 GN=UBE2Q1 PE=1 SV=1,0.002,7.098,6,2,7,2,422,46.1,5.1,2712,,2,,metabolic process;response to stimulus;transport,cytoplasm;cytosol;nucleus,catalytic activity;nucleotide binding;protein binding,,55585,ENSG00000160714.9,UBE2Q1,1,Ubiquitin mediated proteolysis,,Antigen processing: Ubiquitination & Proteasome degradation,5,High,1
Q8N6Y0,Usher syndrome type-1C protein-binding protein 1 OS=Homo sapiens OX=9606 GN=USHBP1 PE=1 SV=1,0.002,7.092,3,2,13,2,703,76,5.8,3252,11.06,1,1,,,protein binding,Pf10506,83878,ENSG00000130307.11,USHBP1,19,,,,0,High,1
O14523,Phospholipid transfer protein C2CD2L OS=Homo sapiens OX=9606 GN=C2CD2L PE=1 SV=3,0.002,7.09,3,2,21,2,706,76.1,7.69,8578,,2,,regulation of biological process;transport,endoplasmic reticulum;membrane,transporter activity,,9854,,C2CD2L,11,,,,0,High,1
P20962,Parathymosin OS=Homo sapiens OX=9606 GN=PTMS PE=1 SV=2,0.002,7.081,11,1,19,1,102,11.5,4.16,11882,,1,,metabolic process,nucleus,,,5763,ENSG00000159335.15,PTMS,12,,,,0,High,1
Q8N5C1,Calcium homeostasis modulator protein 5 OS=Homo sapiens OX=9606 GN=CALHM5 PE=2 SV=1,0.002,7.074,3,1,4,1,309,35.1,8.13,2671,,1,,transport,membrane,transporter activity,Pf14798,254228,ENSG00000178033.5,FAM26E; CALHM5,6,,,,0,High,1
Q8IVG5,Sterile alpha motif domain-containing protein 9-like OS=Homo sapiens OX=9606 GN=SAMD9L PE=1 SV=2,0.002,7.07,2,2,7,2,1584,184.4,8.02,2336,,2,,cell organization and biogenesis,endosome,protein binding,,219285,ENSG00000177409.11,SAMD9L,7,,,,0,High,1
O60449-2,Isoform 2 of Lymphocyte antigen 75 OS=Homo sapiens OX=9606 GN=LY75,0.002,7.066,1,2,24,2,1873,215.6,6.21,8337,,2,,defense response;regulation of biological process;response to stimulus;transport,membrane,receptor activity;signal transducer activity,"Pf00040, Pf00059",100526664; 4065; 9936,ENSG00000248672.5,LY75-CD302; LY75; CD302,2,,,,0,High,1
Q13490,Baculoviral IAP repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=BIRC2 PE=1 SV=2,0.002,7.065,2,1,4,1,618,69.9,6.7,2228,,1,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;cytosol;membrane;nucleus,catalytic activity;enzyme regulator activity;metal ion binding;protein binding,"Pf00619, Pf00653, Pf13639, Pf13920, Pf13923, Pf14634",329,ENSG00000110330.8,BIRC2,11,Hippo signaling pathway; Small cell lung cancer; NF-kappa B signaling pathway; NOD-like receptor signaling pathway; Apoptosis; Pathways in cancer; Platinum drug resistance; Ubiquitin mediated proteolysis; Focal adhesion; TNF signaling pathway; Toxoplasmosis; Apoptosis - multiple species,TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway; TNF alpha Signaling Pathway; Apoptosis; Focal Adhesion; Photodynamic therapy-induced NF-kB survival signaling,"Ub-specific processing proteases; NOD1/2 Signaling Pathway; Regulation of necroptotic cell death; IKK complex recruitment mediated by RIP1; TICAM1, RIP1-mediated IKK complex recruitment ; Apoptotic cleavage of cellular proteins; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway; TNFR1-induced NFkappaB signaling pathway; Activated TLR4 signalling; Regulation of TNFR1 signaling",48,High,1
Q9Y2G0,Protein EFR3 homolog B OS=Homo sapiens OX=9606 GN=EFR3B PE=1 SV=2,0.002,7.063,4,2,5,1,817,92.4,6.7,1406,,2,,cell organization and biogenesis;metabolic process,cytoplasm;cytosol;membrane,protein binding,,22979,ENSG00000084710.13,EFR3B,2,,,,0,High,1
Q69YU5,Uncharacterized protein C12orf73 OS=Homo sapiens OX=9606 GN=C12orf73 PE=3 SV=2,0.002,7.055,35,2,17,2,71,8,9.16,5222,,2,,,extracellular,,Pf14990,728568,ENSG00000204954.9,C12orf73,12,,,,0,High,1
P40189,Interleukin-6 receptor subunit beta OS=Homo sapiens OX=9606 GN=IL6ST PE=1 SV=2,0.002,7.051,2,1,4,1,918,103.5,5.95,1640,,1,,metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,protein binding;receptor activity;signal transducer activity,"Pf00041, Pf06328, Pf09067, Pf09240",3572,ENSG00000134352.19,IL6ST,5,Jak-STAT signaling pathway; Viral carcinogenesis; Signaling pathways regulating pluripotency of stem cells; Cytokine-cytokine receptor interaction,Physiological and Pathological Hypertrophy  of the Heart; MicroRNAs in cardiomyocyte hypertrophy; Interleukin-11 Signaling Pathway; Adipogenesis; Oncostatin M Signaling Pathway; IL-6 signaling pathway; ESC Pluripotency Pathways; Senescence and Autophagy in Cancer,IL-6-type cytokine receptor ligand interactions; MAPK3 (ERK1) activation; Interleukin-35 Signalling; MAPK1 (ERK2) activation; Interleukin-20 family signaling,26,High,1
Q9BXS4,Transmembrane protein 59 OS=Homo sapiens OX=9606 GN=TMEM59 PE=1 SV=1,0.002,7.051,6,2,11,2,323,36.2,5.1,3653,,2,,metabolic process;regulation of biological process,endosome;Golgi;membrane;vacuole,catalytic activity;protein binding,Pf12280,9528,ENSG00000116209.11,TMEM59,1,,,,0,High,1
Q9Y5W7,Sorting nexin-14 OS=Homo sapiens OX=9606 GN=SNX14 PE=1 SV=3,0.002,7.046,3,3,36,3,946,110.1,6.7,13326,,3,,cell organization and biogenesis;transport,endosome;membrane;vacuole,,"Pf00615, Pf00787, Pf02194, Pf08628",57231,ENSG00000135317.12,SNX14,6,,,,0,High,1
O75385,Serine/threonine-protein kinase ULK1 OS=Homo sapiens OX=9606 GN=ULK1 PE=1 SV=2,0.002,7.041,2,2,5,2,1050,112.6,8.79,1384,,2,,cell communication;cell growth;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endosome;membrane;vacuole,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf06293, Pf07714, Pf12063",8408,ENSG00000177169.9,ULK1,12,mTOR signaling pathway; Autophagy; Longevity regulating pathway; AMPK signaling pathway,Target Of Rapamycin (TOR) Signaling; Nanoparticle triggered autophagic cell death; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Senescence and Autophagy in Cancer,TBC/RABGAPs; Macroautophagy; Receptor Mediated Mitophagy; RAB GEFs exchange GTP for GDP on RABs,18,High,1
Q8IWT0,Protein archease OS=Homo sapiens OX=9606 GN=ZBTB8OS PE=1 SV=2,0.002,7.035,6,1,3,1,167,19.5,4.49,1666,,1,,metabolic process,,metal ion binding;protein binding,Pf01951,339487,,ZBTB8OS,1,,,tRNA processing in the nucleus,3,High,1
O60291,E3 ubiquitin-protein ligase MGRN1 OS=Homo sapiens OX=9606 GN=MGRN1 PE=1 SV=2,0.002,7.033,7,2,3,2,552,60.7,5.15,1048,,2,,metabolic process;regulation of biological process;transport,cytoplasm;cytosol;endosome;membrane;nucleus,catalytic activity;metal ion binding;protein binding,"Pf00097, Pf13639, Pf13920, Pf13923, Pf14634",23295,ENSG00000102858.12,MGRN1,16,Ubiquitin mediated proteolysis,,Antigen processing: Ubiquitination & Proteasome degradation,5,High,1
Q6B0K9,Hemoglobin subunit mu OS=Homo sapiens OX=9606 GN=HBM PE=1 SV=1,0.002,7.027,11,1,4,1,141,15.6,6.62,1787,,1,,transport,,metal ion binding;transporter activity,Pf00042,3042,ENSG00000206177.6,HBM,16,,,,0,High,1
Q8WUW1,Protein BRICK1 OS=Homo sapiens OX=9606 GN=BRK1 PE=1 SV=1,0.002,7.022,25,2,2,2,75,8.7,5.45,840,,2,,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol,protein binding,,55845,ENSG00000254999.3,BRK1,3,Regulation of actin cytoskeleton,Regulation of Actin Cytoskeleton,Regulation of actin dynamics for phagocytic cup formation; VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs,13,High,1
Q9UNW9,RNA-binding protein Nova-2 OS=Homo sapiens OX=9606 GN=NOVA2 PE=1 SV=1,0.002,7.019,5,2,5,2,492,49,8.16,1966,,2,,metabolic process;regulation of biological process,nucleus,RNA binding,"Pf00013, Pf13014",4858,ENSG00000104967.6,NOVA2,19,,,,0,High,1
Q9NQS1,Cell death regulator Aven OS=Homo sapiens OX=9606 GN=AVEN PE=1 SV=1,0.002,7.011,10,2,11,2,362,38.5,4.98,3759,,2,,cell death;regulation of biological process,membrane,protein binding,,57099,ENSG00000169857.7,AVEN,15,,,,0,High,1
Q5JR12,Protein phosphatase 1J OS=Homo sapiens OX=9606 GN=PPM1J PE=1 SV=1,0.002,7.008,4,2,3,1,505,54.8,7.46,942,,2,,metabolic process,,catalytic activity,Pf00481,333926,ENSG00000155367.15,PPM1J,1,,Wnt Signaling Pathway and Pluripotency,,1,High,1
P34059,N-acetylgalactosamine-6-sulfatase OS=Homo sapiens OX=9606 GN=GALNS PE=1 SV=1,0.002,7.006,3,2,16,2,522,58,6.74,6442,,2,,metabolic process;transport,extracellular;organelle lumen;vacuole,catalytic activity;metal ion binding,"Pf00884, Pf01663, Pf02995, Pf14707",2588,ENSG00000141012.12,GALNS,16,Glycosaminoglycan degradation; Metabolic pathways; Lysosome,,MPS IV - Morquio syndrome A; Neutrophil degranulation; Keratan sulfate degradation,16,High,1
P51157,Ras-related protein Rab-28 OS=Homo sapiens OX=9606 GN=RAB28 PE=1 SV=2,0.002,7.006,9,2,3,2,221,24.8,5.97,1317,,2,,regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;membrane,catalytic activity;nucleotide binding,"Pf00025, Pf00071, Pf08477",9364,ENSG00000157869.14,RAB28,4,,,,0,High,1
Q8WUD4,Coiled-coil domain-containing protein 12 OS=Homo sapiens OX=9606 GN=CCDC12 PE=1 SV=1,0.002,7.005,14,1,6,1,166,19.2,7.34,2484,,1,,metabolic process,cytoplasm,catalytic activity;nucleotide binding;protein binding,Pf08315,151903,ENSG00000160799.11,CCDC12,3,Spliceosome,,,1,High,1
Q86T13,C-type lectin domain family 14 member A OS=Homo sapiens OX=9606 GN=CLEC14A PE=1 SV=1,0.002,6.964,5,1,5,1,490,51.6,6.35,1788,,1,,,membrane,protein binding,Pf14670,161198,ENSG00000176435.6,CLEC14A,14,,,,0,High,1
Q96S59,Ran-binding protein 9 OS=Homo sapiens OX=9606 GN=RANBP9 PE=1 SV=1,0.002,6.963,3,2,7,2,729,77.8,6.79,2085,,2,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,protein binding,"Pf00622, Pf08513, Pf10607",10048,ENSG00000010017.12,RANBP9,6,,Brain-Derived Neurotrophic Factor (BDNF) signaling pathway,L1CAM interactions; RAF/MAP kinase cascade; MET activates RAS signaling; Interleukin-20 family signaling,15,High,1
Q9HD89,Resistin OS=Homo sapiens OX=9606 GN=RETN PE=1 SV=1,0.002,6.963,10,1,5,1,108,11.4,6.86,2886,,1,,cell differentiation;regulation of biological process;response to stimulus;transport,extracellular;nucleus;organelle lumen,protein binding,Pf06954,56729,ENSG00000104918.7,RETN,19,,Adipogenesis,Neutrophil degranulation,4,High,1
P04280,Basic salivary proline-rich protein 1 OS=Homo sapiens OX=9606 GN=PRB1 PE=1 SV=3,0.002,6.962,13,2,8,1,392,38.5,11.22,2643,,2,,,,,,,,,,,,,0,High,1
Q6UXH1,Protein disulfide isomerase CRELD2 OS=Homo sapiens OX=9606 GN=CRELD2 PE=1 SV=1,0.002,6.959,6,2,4,2,353,38.2,4.59,1315,,2,,,endoplasmic reticulum;extracellular;Golgi,metal ion binding;protein binding,"Pf07645, Pf11938",79174,ENSG00000184164.14,CRELD2,22,,,,0,High,1
Q969U7,Proteasome assembly chaperone 2 OS=Homo sapiens OX=9606 GN=PSMG2 PE=1 SV=1,0.002,6.958,5,1,2,1,264,29.4,6.98,1290,,1,,cell organization and biogenesis;regulation of biological process,cytosol;nucleus;proteasome,protein binding,Pf09754,56984,ENSG00000128789.20,PSMG2,18,,,,0,High,1
P08174-2,Isoform 1 of Complement decay-accelerating factor OS=Homo sapiens OX=9606 GN=CD55,0.002,6.957,5,2,10,2,440,48.7,8.37,2125,9.04,1,1,cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;extracellular;membrane,protein binding;receptor activity,"Pf00084, Pf13900",1604,ENSG00000196352.14,CD55,1,,Allograft Rejection; Complement Activation; Complement and Coagulation Cascades,,3,High,1
Q5SW96,Low density lipoprotein receptor adapter protein 1 OS=Homo sapiens OX=9606 GN=LDLRAP1 PE=1 SV=3,0.002,6.931,4,1,5,1,308,33.9,6.7,2802,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;endosome;membrane,protein binding;structural molecule activity,"Pf00640, Pf08416, Pf14719",26119,ENSG00000157978.11,LDLRAP1,1,Endocytosis,,Cargo recognition for clathrin-mediated endocytosis; LDL clearance; Chylomicron clearance,10,High,1
Q9UEE9,Craniofacial development protein 1 OS=Homo sapiens OX=9606 GN=CFDP1 PE=1 SV=1,0.003,6.931,9,2,3,2,299,33.6,4.81,1102,,2,,development;regulation of biological process,chromosome,,Pf07572,10428,ENSG00000153774.8,CFDP1,16,,,,0,High,1
Q16799,Reticulon-1 OS=Homo sapiens OX=9606 GN=RTN1 PE=1 SV=1,0.003,6.918,5,2,73,2,776,83.6,4.69,31112,,2,,cell differentiation,endoplasmic reticulum;membrane,protein binding,Pf02453,6252,ENSG00000139970.16,RTN1,14,,,,0,High,1
Q08AE8,Protein spire homolog 1 OS=Homo sapiens OX=9606 GN=SPIRE1 PE=1 SV=3,0.003,6.902,5,3,4,3,756,85.5,8.62,1259,,3,,cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;membrane,protein binding,,56907,ENSG00000134278.15,SPIRE1,18,Dorso-ventral axis formation,,,1,High,1
Q71RG4,Transmembrane and ubiquitin-like domain-containing protein 2 OS=Homo sapiens OX=9606 GN=TMUB2 PE=1 SV=2,0.003,6.9,7,1,8,1,321,33.8,5.03,3069,,1,,,membrane,protein binding,Pf00240,79089,ENSG00000168591.15,TMUB2,17,,,,0,High,1
O15040,Tectonin beta-propeller repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=TECPR2 PE=1 SV=4,0.003,6.891,2,3,6,3,1411,153.8,5.55,1735,,3,,metabolic process,,protein binding,Pf06462,9895,ENSG00000196663.15,TECPR2,14,,,,0,High,1
Q9H9Q4,Non-homologous end-joining factor 1 OS=Homo sapiens OX=9606 GN=NHEJ1 PE=1 SV=1,0.003,6.886,8,2,14,2,299,33.3,5.97,4548,,2,,cell differentiation;metabolic process;regulation of biological process;response to stimulus,nucleus,DNA binding;protein binding,Pf09302,79840,ENSG00000187736.12,NHEJ1,2,Non-homologous end-joining,Non-homologous end joining,Nonhomologous End-Joining (NHEJ),5,High,1
Q12851,Mitogen-activated protein kinase kinase kinase kinase 2 OS=Homo sapiens OX=9606 GN=MAP4K2 PE=1 SV=2,0.003,6.88,3,2,4,2,820,91.5,6.34,1346,,2,,defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;Golgi;membrane,catalytic activity;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf00780, Pf07714",5871,ENSG00000168067.11,MAP4K2,11,MAPK signaling pathway,TNF alpha Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; Insulin Signaling,,4,High,1
Q9HAC8,Ubiquitin domain-containing protein 1 OS=Homo sapiens OX=9606 GN=UBTD1 PE=1 SV=1,0.003,6.875,6,2,6,2,227,25.9,7.83,1686,0,2,1,,,protein binding,"Pf00240, Pf11976",80019,ENSG00000165886.4,UBTD1,10,,,,0,High,1
P48382,DNA-binding protein RFX5 OS=Homo sapiens OX=9606 GN=RFX5 PE=1 SV=1,0.003,6.868,4,2,19,2,616,65.3,9.29,4303,,2,,metabolic process;regulation of biological process,nucleus,DNA binding;protein binding,"Pf02257, Pf03288, Pf14621",5993,ENSG00000143390.17,RFX5,1,Tuberculosis; Antigen processing and presentation; Primary immunodeficiency,,,3,High,1
Q96L93,Kinesin-like protein KIF16B OS=Homo sapiens OX=9606 GN=KIF16B PE=1 SV=2,0.003,6.861,2,2,17,1,1317,151.9,6.16,7641,,2,,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endosome;membrane,catalytic activity;motor activity;nucleotide binding;protein binding,"Pf00225, Pf00498, Pf00787, Pf04111",55614,ENSG00000089177.18,KIF16B,20,,,COPI-dependent Golgi-to-ER retrograde traffic; Kinesins,8,High,1
O75896,Tumor suppressor candidate 2 OS=Homo sapiens OX=9606 GN=TUSC2 PE=1 SV=3,0.003,6.859,25,1,4,1,110,12.1,9.69,1820,,1,,cell communication;cell differentiation;cell proliferation;defense response;regulation of biological process;response to stimulus;transport,mitochondrion,protein binding,Pf15000,11334,ENSG00000114383.9,TUSC2,3,,,,0,High,1
Q14005,Pro-interleukin-16 OS=Homo sapiens OX=9606 GN=IL16 PE=1 SV=4,0.003,6.856,3,2,4,2,1332,141.7,8.06,750,,2,,cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;extracellular;membrane;nucleus,protein binding,Pf00595,3603,ENSG00000172349.17,IL16,15,,,Other interleukin signaling,4,High,1
Q96D96,Voltage-gated hydrogen channel 1 OS=Homo sapiens OX=9606 GN=HVCN1 PE=1 SV=1,0.003,6.846,5,1,2,1,273,31.7,6.8,1211,,1,,regulation of biological process;response to stimulus;transport,membrane,protein binding;transporter activity,,84329,ENSG00000122986.13,HVCN1,12,,,Sperm Motility And Taxes; Neutrophil degranulation,6,High,1
O60447,Ecotropic viral integration site 5 protein homolog OS=Homo sapiens OX=9606 GN=EVI5 PE=1 SV=3,0.003,6.844,2,2,9,1,810,92.9,6.1,5657,,2,,cell division;cell proliferation;development;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;nucleus,catalytic activity;enzyme regulator activity;motor activity;protein binding,"Pf00566, Pf01576, Pf02463, Pf04111, Pf05557, Pf06570, Pf07888, Pf12128",7813,ENSG00000067208.14,EVI5,1,,,,0,High,1
P35625,Metalloproteinase inhibitor 3 OS=Homo sapiens OX=9606 GN=TIMP3 PE=1 SV=2,0.003,6.823,6,1,21,1,211,24.1,8.72,9733,,1,,regulation of biological process;response to stimulus;transport,extracellular;nucleus;organelle lumen,enzyme regulator activity;metal ion binding;protein binding,Pf00965,7078,ENSG00000100234.11,TIMP3,22,MicroRNAs in cancer; Proteoglycans in cancer,Matrix Metalloproteinases; Angiogenesis; Oncostatin M Signaling Pathway; Endochondral Ossification,Platelet degranulation,10,High,1
Q9UL63,Muskelin OS=Homo sapiens OX=9606 GN=MKLN1 PE=1 SV=2,0.003,6.822,1,2,17,2,735,84.7,6.34,7455,,2,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytosol,protein binding,"Pf00754, Pf01344, Pf06588, Pf13415, Pf13418",4289,ENSG00000128585.17,MKLN1,7,,,,0,High,1
P25963,NF-kappa-B inhibitor alpha OS=Homo sapiens OX=9606 GN=NFKBIA PE=1 SV=1,0.003,6.804,5,2,4,2,317,35.6,4.68,2148,,2,,cell death;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus,protein binding,"Pf00023, Pf12796, Pf13606, Pf13637, Pf13857",4792,ENSG00000100906.10,NFKBIA,14,B cell receptor signaling pathway; Chemokine signaling pathway; Hepatitis B; Herpes simplex infection; Th1 and Th2 cell differentiation; Apoptosis; Prostate cancer; Legionellosis; Epstein-Barr virus infection; RIG-I-like receptor signaling pathway; NOD-like receptor signaling pathway; Small cell lung cancer; Viral carcinogenesis; HTLV-I infection; Adipocytokine signaling pathway; Leishmaniasis; cAMP signaling pathway; T cell receptor signaling pathway; Cytosolic DNA-sensing pathway; Neurotrophin signaling pathway; Epithelial cell signaling in Helicobacter pylori infection; Chagas disease (American trypanosomiasis); Toxoplasmosis; Shigellosis; Chronic myeloid leukemia; Hepatitis C; NF-kappa B signaling pathway; Insulin resistance; Osteoclast differentiation; Toll-like receptor signaling pathway; Pathways in cancer; Influenza A; TNF signaling pathway; Measles,Nucleotide-binding Oligomerization Domain (NOD) pathway; Regulation of toll-like receptor signaling pathway; IL-1 signaling pathway; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway; Prolactin Signaling Pathway; B Cell Receptor Signaling Pathway; TNF alpha Signaling Pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Apoptosis; EBV LMP1 signaling; Rac1/Pak1/p38/MMP-2 pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection; RIG-I-like Receptor Signaling; VEGFA-VEGFR2 Signaling Pathway; Chemokine signaling pathway; IL-4 Signaling Pathway; T-Cell antigen Receptor (TCR)  Signaling Pathway; Toll-like receptor signaling pathway,IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); Downstream TCR signaling; TRAF6 mediated NF-kB activation; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; RIP-mediated NFkB activation via ZBP1; Activated TLR4 signalling; Interleukin-1 family signaling; Ub-specific processing proteases; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; NF-kB is activated and signals survival; Signalling by NGF; IkBA variant leads to EDA-ID; CLEC7A (Dectin-1) signaling,110,High,1
Q8TCF1,AN1-type zinc finger protein 1 OS=Homo sapiens OX=9606 GN=ZFAND1 PE=1 SV=1,0.003,6.786,3,1,4,1,268,30.8,7.39,1888,,1,,,,metal ion binding,Pf01428,79752,ENSG00000104231.10,ZFAND1,8,,,,0,High,1
Q96G21,U3 small nucleolar ribonucleoprotein protein IMP4 OS=Homo sapiens OX=9606 GN=IMP4 PE=1 SV=1,0.003,6.784,7,2,7,2,291,33.7,9.47,2607,,2,,metabolic process,nucleus,protein binding;RNA binding,Pf04427,92856,ENSG00000136718.9,IMP4,2,Ribosome biogenesis in eukaryotes,,Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol,6,High,1
P43007,Neutral amino acid transporter A OS=Homo sapiens OX=9606 GN=SLC1A4 PE=1 SV=1,0.003,6.778,2,1,5,1,532,55.7,6.25,1994,,1,,cell communication;transport,cell surface;membrane,transporter activity,Pf00375,6509,ENSG00000115902.10,SLC1A4,2,,,Amino acid transport across the plasma membrane,4,High,1
Q8WUD6,Cholinephosphotransferase 1 OS=Homo sapiens OX=9606 GN=CHPT1 PE=1 SV=1,0.003,6.778,3,1,3,1,406,45.1,6.92,2151,,1,,metabolic process;regulation of biological process,Golgi;membrane,catalytic activity;metal ion binding,Pf01066,56994,ENSG00000111666.10,CHPT1,12,Choline metabolism in cancer; Metabolic pathways; Glycerophospholipid metabolism; Ether lipid metabolism,Kennedy pathway; One carbon metabolism and related pathways,Synthesis of PC,11,High,1
Q9Y689,ADP-ribosylation factor-like protein 5A OS=Homo sapiens OX=9606 GN=ARL5A PE=1 SV=1,0.003,6.769,12,2,7,1,179,20.7,6.79,2126,,2,,cell organization and biogenesis;regulation of biological process;response to stimulus,,catalytic activity;nucleotide binding;protein binding;signal transducer activity,"Pf00025, Pf00071, Pf00503, Pf01926, Pf04670, Pf08477, Pf09439",26225,ENSG00000162980.16,ARL5A,2,,,,0,High,1
O00622,CCN family member 1 OS=Homo sapiens OX=9606 GN=CCN1 PE=1 SV=1,0.003,6.766,3,1,3,1,381,42,8.21,1761,,1,,cell communication;cell death;cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process;response to stimulus,extracellular;organelle lumen,nucleotide binding;protein binding,"Pf00007, Pf00090, Pf00093, Pf00219",3491,ENSG00000142871.16,CYR61,1,,Oncostatin M Signaling Pathway; Hypertrophy Model,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs),6,High,1
Q9BT17,Mitochondrial ribosome-associated GTPase 1 OS=Homo sapiens OX=9606 GN=MTG1 PE=1 SV=2,0.003,6.764,12,3,5,3,334,37.2,9.47,1381,,3,,regulation of biological process,membrane;mitochondrion;organelle lumen;ribosome,catalytic activity;nucleotide binding,"Pf00009, Pf01926, Pf02421, Pf03193",92170,ENSG00000148824.18,MTG1,10,,,,0,High,1
P09234,U1 small nuclear ribonucleoprotein C OS=Homo sapiens OX=9606 GN=SNRPC PE=1 SV=1,0.003,6.762,8,1,7,1,159,17.4,9.67,3817,,1,,cell organization and biogenesis;metabolic process,nucleus;spliceosomal complex,metal ion binding;protein binding;RNA binding,Pf06220,6631,ENSG00000124562.9,SNRPC,6,Spliceosome,,mRNA Splicing - Major Pathway,5,High,1
O95428,Papilin OS=Homo sapiens OX=9606 GN=PAPLN PE=2 SV=4,0.003,6.761,3,2,4,2,1278,137.6,6.89,1356,,2,,metabolic process;regulation of biological process,extracellular,catalytic activity;enzyme regulator activity;metal ion binding;protein binding,"Pf00014, Pf00047, Pf00090, Pf05986, Pf07679, Pf07686, Pf08686, Pf13895, Pf13927",89932,ENSG00000100767.15,PAPLN,14,,,,0,High,1
Q96F63,Coiled-coil domain-containing protein 97 OS=Homo sapiens OX=9606 GN=CCDC97 PE=1 SV=1,0.003,6.761,8,2,2,2,343,38.9,4.59,1024,,2,,,,,Pf09747,90324,ENSG00000142039.3,CCDC97,19,,,,0,High,1
Q8WVI0,Small integral membrane protein 4 OS=Homo sapiens OX=9606 GN=SMIM4 PE=1 SV=2,0.003,6.749,16,1,8,1,70,8.7,10.87,3997,,1,,,membrane;mitochondrion,,Pf15114,440957,ENSG00000168273.7,SMIM4,3,,,,0,High,1
O75940,Survival of motor neuron-related-splicing factor 30 OS=Homo sapiens OX=9606 GN=SMNDC1 PE=1 SV=1,0.003,6.734,13,2,7,2,238,26.7,7.24,1546,,2,,cell death;metabolic process,cytoplasm;nucleus;spliceosomal complex,protein binding;RNA binding,Pf06003,10285,ENSG00000119953.12,SMNDC1,10,Spliceosome,,mRNA Splicing - Major Pathway,5,High,1
O95983,Methyl-CpG-binding domain protein 3 OS=Homo sapiens OX=9606 GN=MBD3 PE=1 SV=1,0.003,6.732,8,2,6,2,291,32.8,5.34,2079,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding,"Pf01429, Pf14048",53615,ENSG00000071655.17,MBD3,19,,,ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation,20,High,1
A6NKD9,Coiled-coil domain-containing protein 85C OS=Homo sapiens OX=9606 GN=CCDC85C PE=1 SV=1,0.003,6.73,3,1,6,1,419,45.2,6.96,2150,,1,,development,,,Pf10226,317762,ENSG00000205476.8,CCDC85C,14,,,,0,High,1
Q6IN84,"rRNA methyltransferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=MRM1 PE=1 SV=1",0.003,6.728,5,2,6,2,353,38.6,7.94,2100,,2,,metabolic process,mitochondrion;organelle lumen,catalytic activity;protein binding;RNA binding,"Pf00588, Pf08032",79922,ENSG00000274853.2; ENSG00000278619.4,MRM1,17; CHR_HSCHR17_7_CTG4,,,rRNA modification in the mitochondrion,4,High,1
Q2LD37,Transmembrane protein KIAA1109 OS=Homo sapiens OX=9606 GN=KIAA1109 PE=1 SV=2,0.003,6.727,0,2,5,2,5005,555.1,6.58,2349,,2,,regulation of biological process,membrane;nucleus,protein binding,Pf10479,84162,ENSG00000138688.15,KIAA1109,4,,,,0,High,1
P49918,Cyclin-dependent kinase inhibitor 1C OS=Homo sapiens OX=9606 GN=CDKN1C PE=1 SV=1,0.003,6.724,9,2,2,2,316,32.2,5.52,661,,2,,cell differentiation;metabolic process;regulation of biological process,cytoplasm;nucleus,enzyme regulator activity;protein binding,Pf02234,1028,ENSG00000129757.12,CDKN1C,11,Cell cycle,Primary Focal Segmental Glomerulosclerosis FSGS; Dopaminergic Neurogenesis; Oxidative Damage; G1 to S cell cycle control; Endochondral Ossification,Cyclin D associated events in G1,11,High,1
Q9ULG6,Cell cycle progression protein 1 OS=Homo sapiens OX=9606 GN=CCPG1 PE=1 SV=3,0.003,6.716,3,2,4,2,757,87.3,5.95,1647,,2,,regulation of biological process,membrane,protein binding,,9236,ENSG00000260916.7,CCPG1,15,,,,0,High,1
Q96HW7,Integrator complex subunit 4 OS=Homo sapiens OX=9606 GN=INTS4 PE=1 SV=2,0.003,6.703,3,2,7,2,963,108.1,6.44,2336,,2,,metabolic process;transport,nucleus,protein binding,"Pf01602, Pf12717, Pf12755, Pf13646",92105,ENSG00000149262.16,INTS4,11,,,RNA polymerase II transcribes snRNA genes,3,High,1
P78345,Ribonuclease P protein subunit p38 OS=Homo sapiens OX=9606 GN=RPP38 PE=1 SV=2,0.003,6.694,6,2,62,2,283,31.8,9.92,18171,,2,,metabolic process,nucleus,catalytic activity;protein binding,Pf01248,10557,ENSG00000152464.14,RPP38,10,Ribosome biogenesis in eukaryotes; RNA transport,Integrated Breast Cancer Pathway,Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus,9,High,1
Q9BSA9,Endosomal/lysosomal potassium channel TMEM175 OS=Homo sapiens OX=9606 GN=TMEM175 PE=1 SV=1,0.003,6.681,4,2,9,2,504,55.6,7.66,3524,,2,,cell organization and biogenesis;cellular homeostasis;transport,endosome;membrane;vacuole,transporter activity,Pf06736,84286,ENSG00000127419.16,TMEM175,4,,,,0,High,1
Q07820,Induced myeloid leukemia cell differentiation protein Mcl-1 OS=Homo sapiens OX=9606 GN=MCL1 PE=1 SV=3,0.003,6.681,5,2,3,2,350,37.3,5.66,1320,,2,,cell death;cell differentiation;cell organization and biogenesis;cellular component movement;cellular homeostasis;development;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;mitochondrion;nucleus;organelle lumen,protein binding;transporter activity,Pf00452,4170,ENSG00000143384.12,MCL1,1,MicroRNAs in cancer; Jak-STAT signaling pathway; PI3K-Akt signaling pathway; Apoptosis,Apoptosis; Photodynamic therapy-induced HIF-1 survival signaling; Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex,Interleukin-4 and 13 signaling,11,High,1
Q7L8J4,SH3 domain-binding protein 5-like OS=Homo sapiens OX=9606 GN=SH3BP5L PE=1 SV=1,0.003,6.68,5,1,3,1,393,43.5,5.77,2147,,1,,regulation of biological process;response to stimulus,cytoplasm,enzyme regulator activity;protein binding,Pf05276,80851,ENSG00000175137.10,SH3BP5L,1,,,,0,High,1
Q96EK9,Protein KTI12 homolog OS=Homo sapiens OX=9606 GN=KTI12 PE=1 SV=1,0.003,6.671,5,1,2,1,354,38.6,6.95,781,,1,,,,nucleotide binding;protein binding,"Pf08433, Pf13671",112970,ENSG00000198841.3,KTI12,1,,,,0,High,1
P35250,Replication factor C subunit 2 OS=Homo sapiens OX=9606 GN=RFC2 PE=1 SV=3,0.003,6.67,8,2,6,2,354,39.1,6.44,2450,,2,,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding,"Pf00004, Pf01078, Pf01443, Pf03215, Pf05496, Pf08542, Pf13086, Pf13173, Pf13177, Pf13191, Pf13207, Pf13238, Pf13245, Pf13401",5982,ENSG00000049541.10,RFC2,7,Nucleotide excision repair; DNA replication; Mismatch repair,DNA Replication,Translesion Synthesis by POLH; Termination of translesion DNA synthesis; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Translesion synthesis by REV1; Polymerase switching on the C-strand of the telomere; Regulation of TP53 Activity through Phosphorylation; PCNA-Dependent Long Patch Base Excision Repair; G2/M DNA damage checkpoint; Translesion synthesis by POLK; Gap-filling DNA repair synthesis and ligation in TC-NER; Presynaptic phase of homologous DNA pairing and strand exchange; Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Polymerase switching; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA),56,High,1
Q96ER3,Protein SAAL1 OS=Homo sapiens OX=9606 GN=SAAL1 PE=1 SV=2,0.003,6.665,4,2,4,2,474,53.5,4.5,1326,,2,,,nucleus,,,113174,ENSG00000166788.9,SAAL1,11,,,,0,High,1
Q9BPZ7,Target of rapamycin complex 2 subunit MAPKAP1 OS=Homo sapiens OX=9606 GN=MAPKAP1 PE=1 SV=2,0.003,6.664,3,1,5,1,522,59.1,7.55,2187,,1,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytosol;Golgi;membrane;nucleus,protein binding,Pf05422,79109,ENSG00000119487.16,MAPKAP1,9,mTOR signaling pathway,Target Of Rapamycin (TOR) Signaling; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; Interferon type I signaling pathways,PIP3 activates AKT signaling; CD28 dependent PI3K/Akt signaling; Regulation of TP53 Degradation; VEGFR2 mediated vascular permeability; Constitutive Signaling by AKT1 E17K in Cancer,28,High,1
Q99575,Ribonucleases P/MRP protein subunit POP1 OS=Homo sapiens OX=9606 GN=POP1 PE=1 SV=2,0.003,6.649,3,2,8,2,1024,114.6,9.22,1823,,2,,metabolic process,Golgi;mitochondrion;nucleus,catalytic activity;protein binding;RNA binding,"Pf06978, Pf08170",10940,ENSG00000104356.10,POP1,8,Ribosome biogenesis in eukaryotes; RNA transport,,tRNA processing in the nucleus,5,High,1
Q9HBW9,Adhesion G protein-coupled receptor L4 OS=Homo sapiens OX=9606 GN=ADGRL4 PE=1 SV=3,0.003,6.631,4,2,3,2,690,77.8,7.61,823,,2,,regulation of biological process;response to stimulus,cell surface;membrane,metal ion binding;protein binding;receptor activity;signal transducer activity,"Pf00002, Pf01825, Pf06247, Pf07645, Pf12003, Pf12947",64123,ENSG00000162618.13,ELTD1; ADGRL4,1,,"GPCRs, Class B Secretin-like",,1,High,1
P14555,"Phospholipase A2, membrane associated OS=Homo sapiens OX=9606 GN=PLA2G2A PE=1 SV=2",0.003,6.623,5,1,37,1,144,16.1,9.23,21327,,1,,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;extracellular;membrane,catalytic activity;metal ion binding,Pf00068,5320,ENSG00000188257.10,PLA2G2A,1,alpha-Linolenic acid metabolism; Pancreatic secretion; Vascular smooth muscle contraction; Ras signaling pathway; Linoleic acid metabolism; Ether lipid metabolism; Metabolic pathways; Glycerophospholipid metabolism; Arachidonic acid metabolism; Fat digestion and absorption,MicroRNAs in cardiomyocyte hypertrophy; Eicosanoid Synthesis; Spinal Cord Injury; Cardiac Hypertrophic Response,Acyl chain remodelling of PI; Synthesis of PA; Acyl chain remodelling of PG; Antimicrobial peptides; Acyl chain remodelling of PS; Acyl chain remodelling of PE; Acyl chain remodelling of PC,27,High,1
Q49AR2,UPF0489 protein C5orf22 OS=Homo sapiens OX=9606 GN=C5orf22 PE=1 SV=2,0.003,6.619,7,2,3,2,442,49.9,4.78,1008,,2,,,,protein binding,"Pf10098, Pf12640",55322,ENSG00000082213.17,C5orf22,5,,,,0,High,1
Q96H96,"4-hydroxybenzoate polyprenyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=COQ2 PE=1 SV=1",0.003,6.614,6,2,8,2,371,40.5,9.13,2802,,2,,metabolic process,membrane;mitochondrion,catalytic activity,Pf01040,27235,,COQ2,4,Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways,,Mitochondrial protein import; Ubiquinol biosynthesis; Metabolism of proteins,8,High,1
P26006,Integrin alpha-3 OS=Homo sapiens OX=9606 GN=ITGA3 PE=1 SV=5,0.003,6.61,1,1,6,1,1051,116.5,6.77,3282,,1,,cell differentiation;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cell surface;membrane,metal ion binding;protein binding,"Pf01839, Pf08441, Pf13517",3675,ENSG00000005884.17,ITGA3,17,PI3K-Akt signaling pathway; Regulation of actin cytoskeleton; Hematopoietic cell lineage; ECM-receptor interaction; Focal adhesion; Dilated cardiomyopathy; Hypertrophic cardiomyopathy (HCM); Small cell lung cancer; Pathways in cancer; Arrhythmogenic right ventricular cardiomyopathy (ARVC),Integrin-mediated Cell Adhesion; Arrhythmogenic Right Ventricular Cardiomyopathy; Primary Focal Segmental Glomerulosclerosis FSGS; Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,Integrin cell surface interactions; Laminin interactions; Basigin interactions; MET activates PTK2 signaling,26,High,1
Q9BVJ6,U3 small nucleolar RNA-associated protein 14 homolog A OS=Homo sapiens OX=9606 GN=UTP14A PE=1 SV=1,0.003,6.607,8,3,4,3,771,87.9,7.87,595,,3,,metabolic process,cytosol;nucleus,protein binding;RNA binding,Pf04615,10813,ENSG00000156697.12,UTP14A,X,Ribosome biogenesis in eukaryotes,,Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol,6,High,1
Q9UKG9,Peroxisomal carnitine O-octanoyltransferase OS=Homo sapiens OX=9606 GN=CROT PE=1 SV=2,0.003,6.6,3,1,2,1,612,70.1,7.08,1296,,1,,metabolic process;transport,mitochondrion;organelle lumen,catalytic activity;protein binding,Pf00755,54677,ENSG00000005469.11,CROT,7,Peroxisome,,Beta-oxidation of pristanoyl-CoA,6,High,1
O95466,Formin-like protein 1 OS=Homo sapiens OX=9606 GN=FMNL1 PE=1 SV=3,0.003,6.599,2,2,4,1,1100,121.8,5.72,1578,,2,,cell organization and biogenesis;cellular component movement;regulation of biological process,cytoplasm;cytosol;membrane,protein binding,"Pf02181, Pf06367, Pf06371",752,ENSG00000184922.13,FMNL1,17,,,RHO GTPases Activate Formins,4,High,1
Q9UNW1,Multiple inositol polyphosphate phosphatase 1 OS=Homo sapiens OX=9606 GN=MINPP1 PE=1 SV=1,0.003,6.598,4,2,3,2,487,55,7.81,1427,,2,,metabolic process,endoplasmic reticulum;organelle lumen,catalytic activity,Pf00328,9562,ENSG00000107789.15,MINPP1,10,Metabolic pathways; Inositol phosphate metabolism; Glycolysis / Gluconeogenesis,,Synthesis of IPs in the ER lumen,6,High,1
Q96JK2,DDB1- and CUL4-associated factor 5 OS=Homo sapiens OX=9606 GN=DCAF5 PE=1 SV=2,0.003,6.593,2,2,11,2,942,103.9,5.76,4654,,2,,metabolic process,mitochondrion,protein binding,Pf00400,8816,ENSG00000139990.17,DCAF5,14,,,Neddylation,3,High,1
Q9NUN5,Probable lysosomal cobalamin transporter OS=Homo sapiens OX=9606 GN=LMBRD1 PE=1 SV=1,0.003,6.591,3,1,4,1,540,61.3,7.77,1964,,1,,metabolic process;regulation of biological process;transport,membrane;vacuole,protein binding;transporter activity,Pf04791,55788,ENSG00000168216.10,LMBRD1,6,Vitamin digestion and absorption,,"Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF; Cobalamin (Cbl, vitamin B12) transport and metabolism",10,High,1
Q13103,Secreted phosphoprotein 24 OS=Homo sapiens OX=9606 GN=SPP2 PE=1 SV=1,0.003,6.589,11,2,3,2,211,24.3,8.32,1015,,2,,metabolic process;regulation of biological process;transport,extracellular;organelle lumen,enzyme regulator activity,Pf07448,6694,ENSG00000072080.10,SPP2,2,,,Platelet degranulation ; Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs),8,High,1
Q12933,TNF receptor-associated factor 2 OS=Homo sapiens OX=9606 GN=TRAF2 PE=1 SV=2,0.003,6.581,3,2,14,2,501,55.8,7.53,6968,,2,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;metal ion binding;protein binding;signal transducer activity,"Pf00097, Pf00917, Pf02176, Pf04582",7186,ENSG00000127191.17,TRAF2,9,TNF signaling pathway; Small cell lung cancer; Apoptosis; Pathways in cancer; Osteoclast differentiation; Hepatitis C; Viral carcinogenesis; Sphingolipid signaling pathway; NF-kappa B signaling pathway; MAPK signaling pathway; RIG-I-like receptor signaling pathway; NOD-like receptor signaling pathway; Adipocytokine signaling pathway; Herpes simplex infection; Non-alcoholic fatty liver disease (NAFLD); Protein processing in endoplasmic reticulum; Epstein-Barr virus infection,RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway; TNF alpha Signaling Pathway; Apoptosis; MAPK Signaling Pathway; RIG-I-like Receptor Signaling; Oxidative Damage; p38 MAPK Signaling Pathway,Ub-specific processing proteases; TRAF6 mediated NF-kB activation; TNFR1-induced proapoptotic signaling; TRAF6 mediated IRF7 activation; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway; TNFR1-induced NFkappaB signaling pathway; Dimerization of procaspase-8; Regulation of TNFR1 signaling; Regulation by c-FLIP; CASP8 activity is inhibited,53,High,1
Q86V15,Zinc finger protein castor homolog 1 OS=Homo sapiens OX=9606 GN=CASZ1 PE=1 SV=4,0.003,6.573,1,1,2,1,1759,189.9,7.03,934,,1,,development;metabolic process;regulation of biological process,cytosol;nucleus,DNA binding;metal ion binding,,54897,ENSG00000130940.14,CASZ1,1,,,,0,High,1
Q92600,CCR4-NOT transcription complex subunit 9 OS=Homo sapiens OX=9606 GN=CNOT9 PE=1 SV=1,0.003,6.561,4,1,7,1,299,33.6,8.03,3388,,1,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,protein binding,Pf04078,9125,ENSG00000144580.13,RQCD1; CNOT9,2,RNA degradation,,Activation of anterior HOX genes in hindbrain development during early embryogenesis; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Deadenylation of mRNA,13,High,1
Q9Y2X0,Mediator of RNA polymerase II transcription subunit 16 OS=Homo sapiens OX=9606 GN=MED16 PE=1 SV=2,0.003,6.543,2,2,13,1,877,96.7,7.37,5005,,2,,metabolic process;regulation of biological process;response to stimulus,membrane;nucleus,catalytic activity;protein binding;receptor activity,"Pf00400, Pf11635",10025,ENSG00000175221.14,MED16,19,Thyroid hormone signaling pathway,,Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway,10,High,1
A1L4H1,Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D OS=Homo sapiens OX=9606 GN=SSC5D PE=1 SV=3,0.003,6.542,1,1,2,1,1573,165.6,6.13,1026,,1,,defense response;development;regulation of biological process;response to stimulus;transport,cytoplasm;extracellular;membrane,protein binding;receptor activity,Pf00530,284297,ENSG00000179954.15,SSC5D,19,,,Scavenging by Class B Receptors,3,High,1
Q9Y223,Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase OS=Homo sapiens OX=9606 GN=GNE PE=1 SV=1,0.003,6.538,3,2,3,2,722,79.2,6.8,1135,,2,,metabolic process,cytoplasm;cytosol,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00370, Pf00480, Pf02350, Pf07085",10020,ENSG00000159921.14,GNE,9,Amino sugar and nucleotide sugar metabolism; Metabolic pathways,,"Sialic acid metabolism; Defective GNE causes sialuria, Nonaka myopathy and inclusion body myopathy 2",12,High,1
Q8N3F0,Maturin OS=Homo sapiens OX=9606 GN=MTURN PE=1 SV=2,0.003,6.532,9,1,9,1,131,14.9,4.17,4647,,1,,development,,,Pf15167,222166,ENSG00000180354.15,C7orf41; MTURN,7,,,,0,High,1
O75636,Ficolin-3 OS=Homo sapiens OX=9606 GN=FCN3 PE=1 SV=2,0.003,6.525,5,1,10,1,299,32.9,6.67,3324,,1,,defense response;metabolic process;regulation of biological process;response to stimulus,extracellular,catalytic activity;metal ion binding;protein binding,Pf00147,8547,ENSG00000142748.12,FCN3,1,,,Ficolins bind to repetitive carbohydrate structures on the target cell surface,7,High,1
Q3KR37,Protein Aster-B OS=Homo sapiens OX=9606 GN=GRAMD1B PE=1 SV=1,0.003,6.519,3,2,7,2,738,85.3,6.21,2382,,2,,,membrane,,Pf02893,57476,ENSG00000023171.16,GRAMD1B,11,,Ectoderm Differentiation,,1,High,1
Q6VVB1,E3 ubiquitin-protein ligase NHLRC1 OS=Homo sapiens OX=9606 GN=NHLRC1 PE=1 SV=2,0.003,6.519,6,2,4,2,395,42.3,7.34,1458,,2,,metabolic process;regulation of biological process,cytosol;endoplasmic reticulum;nucleus,catalytic activity;metal ion binding;protein binding,,378884,ENSG00000187566.5,NHLRC1,6,Ubiquitin mediated proteolysis,,Glycogen synthesis; Myoclonic epilepsy of Lafora,10,High,1
Q13636,Ras-related protein Rab-31 OS=Homo sapiens OX=9606 GN=RAB31 PE=1 SV=1,0.003,6.516,18,2,5,2,194,21.6,7.06,1690,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;endosome;Golgi;membrane,catalytic activity;nucleotide binding,"Pf00009, Pf00025, Pf00071, Pf04670, Pf08477",11031,,RAB31,18,Endocytosis,,Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation,11,High,1
Q9ULL8,Protein Shroom4 OS=Homo sapiens OX=9606 GN=SHROOM4 PE=1 SV=3,0.003,6.503,1,1,3,1,1493,164.8,6.65,1835,,1,,cell organization and biogenesis;development,cytoplasm;cytoskeleton;membrane,protein binding,"Pf00595, Pf08687",57477,ENSG00000158352.15,SHROOM4,X,Tight junction,,,1,High,1
O15269,Serine palmitoyltransferase 1 OS=Homo sapiens OX=9606 GN=SPTLC1 PE=1 SV=1,0.003,6.494,4,2,5,2,473,52.7,6.01,1809,,2,,metabolic process,endoplasmic reticulum;membrane,catalytic activity;protein binding,Pf00155,10558,ENSG00000090054.13,SPTLC1,9,Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway,Sphingolipid Metabolism,Sphingolipid de novo biosynthesis,8,High,1
O15155,BET1 homolog OS=Homo sapiens OX=9606 GN=BET1 PE=1 SV=1,0.003,6.492,9,1,3,1,118,13.3,9.06,2128,,1,,cell organization and biogenesis;transport,endoplasmic reticulum;Golgi;membrane,protein binding,Pf05739,10282,ENSG00000105829.11,BET1,7,SNARE interactions in vesicular transport,,COPI-mediated anterograde transport; COPII (Coat Protein 2) Mediated Vesicle Transport,10,High,1
Q15648,Mediator of RNA polymerase II transcription subunit 1 OS=Homo sapiens OX=9606 GN=MED1 PE=1 SV=4,0.003,6.492,2,2,6,2,1581,168.4,8.73,3269,,2,,cell differentiation;cell organization and biogenesis;cell proliferation;development;metabolic process;regulation of biological process;response to stimulus;transport,chromosome;membrane;nucleus,catalytic activity;DNA binding;protein binding;receptor activity,Pf10744,5469,ENSG00000125686.11,MED1,17,Endocrine resistance; Thyroid hormone signaling pathway,Energy Metabolism; H19 action Rb-E2F1 signaling and CDK-beta-catenin activity,"Nuclear Receptor transcription pathway; Transcriptional regulation of white adipocyte differentiation; Activation of gene expression by SREBF (SREBP); YAP1- and WWTR1 (TAZ)-stimulated gene expression; Transcriptional activation of mitochondrial biogenesis; RORA activates gene expression; PPARA activates gene expression; BMAL1:CLOCK,NPAS2 activates circadian gene expression; RUNX3 regulates YAP1-mediated transcription",26,High,1
Q8IZE3,Protein-associating with the carboxyl-terminal domain of ezrin OS=Homo sapiens OX=9606 GN=SCYL3 PE=1 SV=3,0.003,6.489,1,1,2,1,742,82.8,5.05,1215,,1,,cellular component movement;metabolic process,cytoplasm;Golgi,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf07714",57147,ENSG00000000457.13,SCYL3,1,,,,0,High,1
Q58EX2,Protein sidekick-2 OS=Homo sapiens OX=9606 GN=SDK2 PE=1 SV=3,0.003,6.487,1,2,37,1,2172,239.2,7.06,17061,,2,,cell differentiation;cell organization and biogenesis,membrane,protein binding,"Pf00041, Pf00047, Pf07679, Pf09294, Pf13895, Pf13927",54549,ENSG00000069188.16,SDK2,17,,,SDK interactions,4,High,1
Q9GZM5,Protein YIPF3 OS=Homo sapiens OX=9606 GN=YIPF3 PE=1 SV=1,0.003,6.484,5,2,11,2,350,38.2,5.76,3760,,2,,cell differentiation,cytoplasm;Golgi;membrane,protein binding,Pf04893,25844,ENSG00000137207.11,YIPF3,6,,,,0,High,1
Q9H4F8,SPARC-related modular calcium-binding protein 1 OS=Homo sapiens OX=9606 GN=SMOC1 PE=1 SV=1,0.003,6.48,3,1,2,1,434,48.1,8.22,903,,1,,cell differentiation;development;regulation of biological process;response to stimulus,extracellular,metal ion binding;protein binding,"Pf00086, Pf07648, Pf10591",64093,ENSG00000198732.10,SMOC1,14,,,,0,High,1
Q8IXH7,Negative elongation factor C/D OS=Homo sapiens OX=9606 GN=NELFCD PE=1 SV=2,0.003,6.477,3,2,26,2,590,66.2,5.1,9434,,2,,metabolic process;regulation of biological process,membrane;nucleus,protein binding;RNA binding,Pf04858,51497,,NELFCD; TH1L,20,,Initiation of transcription and translation elongation at the HIV-1 LTR,HIV elongation arrest and recovery; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat; TP53 Regulates Transcription of DNA Repair Genes; Tat-mediated HIV elongation arrest and recovery; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase II Pre-transcription Events; Pausing and recovery of HIV elongation; Pausing and recovery of Tat-mediated HIV elongation; Formation of HIV-1 elongation complex containing HIV-1 Tat; Formation of the Early Elongation Complex,26,High,1
Q8WXR4,Myosin-IIIb OS=Homo sapiens OX=9606 GN=MYO3B PE=2 SV=4,0.003,6.469,1,1,7,1,1341,151.7,8.15,4480,,1,,metabolic process;response to stimulus,cytoplasm;cytoskeleton,catalytic activity;motor activity;nucleotide binding;protein binding,"Pf00063, Pf00069, Pf00612, Pf07714",140469,ENSG00000071909.18,MYO3B,2,,,,0,High,1
Q96T23,Remodeling and spacing factor 1 OS=Homo sapiens OX=9606 GN=RSF1 PE=1 SV=2,0.003,6.459,2,2,15,2,1441,163.7,5.01,3542,,2,,cell organization and biogenesis;metabolic process;regulation of biological process,nucleus,catalytic activity;metal ion binding;protein binding,"Pf00628, Pf15612, Pf15613",51773,ENSG00000048649.13,RSF1,11,,,Deposition of new CENPA-containing nucleosomes at the centromere,4,High,1
Q8N5M4,Tetratricopeptide repeat protein 9C OS=Homo sapiens OX=9606 GN=TTC9C PE=1 SV=1,0.003,6.456,14,2,3,2,171,20,8.92,1077,,2,,,,protein binding,"Pf13414, Pf13424, Pf13432",283237,ENSG00000162222.13,TTC9C,11,,,,0,High,1
P05981,Serine protease hepsin OS=Homo sapiens OX=9606 GN=HPN PE=1 SV=1,0.003,6.447,2,2,14,1,417,45,7.62,4500,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;membrane,catalytic activity;protein binding;transporter activity,"Pf00089, Pf09272, Pf09342, Pf15494",3249,ENSG00000105707.13,HPN,19,Viral carcinogenesis,,MET Receptor Activation; Signaling by MST1,6,High,1
P07148,"Fatty acid-binding protein, liver OS=Homo sapiens OX=9606 GN=FABP1 PE=1 SV=1",0.003,6.446,17,2,2,2,127,14.2,7.18,768,,2,,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus;organelle lumen,antioxidant activity;catalytic activity;protein binding;transporter activity,Pf14651,2168,ENSG00000163586.9,FABP1,2,Fat digestion and absorption; PPAR signaling pathway,Selenium Metabolism and Selenoproteins; PPAR Alpha Pathway; PPAR signaling pathway,Triglyceride catabolism; PPARA activates gene expression,11,High,1
Q13444,Disintegrin and metalloproteinase domain-containing protein 15 OS=Homo sapiens OX=9606 GN=ADAM15 PE=1 SV=4,0.003,6.445,1,1,6,1,863,92.9,6.73,2470,,1,,cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,cell surface;membrane,catalytic activity;metal ion binding;protein binding,"Pf00200, Pf00413, Pf01421, Pf01562, Pf08516, Pf13574, Pf13582, Pf13583, Pf13688",8751,ENSG00000143537.13,ADAM15,1,,,Degradation of the extracellular matrix; Invadopodia formation,3,High,1
P22681,E3 ubiquitin-protein ligase CBL OS=Homo sapiens OX=9606 GN=CBL PE=1 SV=2,0.003,6.443,3,2,4,2,906,99.6,6.54,1907,,2,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus;vacuole,catalytic activity;metal ion binding;protein binding;signal transducer activity,"Pf00097, Pf00627, Pf02262, Pf02761, Pf02762, Pf13639, Pf13920, Pf13923, Pf14447, Pf14634, Pf15227",867,ENSG00000110395.6,CBL,11,Endocytosis; Proteoglycans in cancer; Ubiquitin mediated proteolysis; ErbB signaling pathway; T cell receptor signaling pathway; Bacterial invasion of epithelial cells; Pathways in cancer; Chronic myeloid leukemia; Insulin signaling pathway,RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; Prolactin Signaling Pathway; Signaling Pathways in Glioblastoma; B Cell Receptor Signaling Pathway; IL-3 Signaling Pathway; Kit receptor signaling pathway; Association Between Physico-Chemical Features and Toxicity Associated Pathways; T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; IL-4 Signaling Pathway; EGF/EGFR Signaling Pathway; Insulin Signaling; IL-2 Signaling Pathway; Interferon type I signaling pathways; T-Cell antigen Receptor (TCR)  Signaling Pathway,Spry regulation of FGF signaling; Cargo recognition for clathrin-mediated endocytosis; TGF-beta receptor signaling activates SMADs; Constitutive Signaling by EGFRvIII; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; EGFR downregulation; Negative regulation of MET activity; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Regulation of signaling by CBL; Regulation of KIT signaling; Interleukin-6 family signaling; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; InlB-mediated entry of Listeria monocytogenes into host cell,72,High,1
Q6ZW49,PAX-interacting protein 1 OS=Homo sapiens OX=9606 GN=PAXIP1 PE=1 SV=2,0.003,6.441,2,2,9,1,1069,121.3,6.7,2499,,2,,cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,chromosome;nucleus,protein binding,"Pf00533, Pf12738",22976,ENSG00000157212.18,PAXIP1,7,,,Nonhomologous End-Joining (NHEJ); Activation of anterior HOX genes in hindbrain development during early embryogenesis,6,High,1
Q969U6,F-box/WD repeat-containing protein 5 OS=Homo sapiens OX=9606 GN=FBXW5 PE=1 SV=1,0.003,6.441,4,2,3,2,566,63.9,6.33,1097,,2,,metabolic process;regulation of biological process,cytoplasm;cytosol,catalytic activity;protein binding,"Pf00400, Pf00646, Pf12937",54461,ENSG00000159069.13,FBXW5,9,,Regulation of toll-like receptor signaling pathway,Association of TriC/CCT with target proteins during biosynthesis; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation,11,High,1
O14578,Citron Rho-interacting kinase OS=Homo sapiens OX=9606 GN=CIT PE=1 SV=2,0.003,6.441,1,3,48,3,2027,231.3,6.57,18118,,3,,cell death;cell differentiation;cell division;cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane,catalytic activity;metal ion binding;motor activity;nucleotide binding;protein binding;structural molecule activity;transporter activity,"Pf00038, Pf00069, Pf00130, Pf00169, Pf00433, Pf00780, Pf01496, Pf01576, Pf01636, Pf02463, Pf03962, Pf04111, Pf04156, Pf05557, Pf05622, Pf05667, Pf07714, Pf07888, Pf07926, Pf08614, Pf10174, Pf12128, Pf14531",11113,ENSG00000122966.15,CIT,12,,G13 Signaling Pathway,RHO GTPases activate CIT,5,High,1
Q96B49,Mitochondrial import receptor subunit TOM6 homolog OS=Homo sapiens OX=9606 GN=TOMM6 PE=1 SV=1,0.003,6.432,38,1,3,1,74,8,4.89,1751,,1,,cell communication;metabolic process;response to stimulus;transport,membrane;mitochondrion,,Pf15184,100188893,ENSG00000214736.7,TOMM6,6,,,Mitochondrial protein import; Metabolism of proteins; Pink/Parkin Mediated Mitophagy,4,High,1
Q7L5Y1,Mitochondrial enolase superfamily member 1 OS=Homo sapiens OX=9606 GN=ENOSF1 PE=1 SV=1,0.003,6.429,4,2,2,2,443,49.8,6.48,882,,2,,metabolic process,mitochondrion,catalytic activity;metal ion binding,"Pf01188, Pf02746, Pf13378",55556,ENSG00000132199.18,ENOSF1,18,Fructose and mannose metabolism,,,1,High,1
Q8NFG4,Folliculin OS=Homo sapiens OX=9606 GN=FLCN PE=1 SV=1,0.003,6.426,4,2,6,2,579,64.4,6.23,2014,,2,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus;vacuole,protein binding,Pf11704,201163,ENSG00000154803.12,FLCN,17,mTOR signaling pathway; Renal cell carcinoma,,,2,High,1
Q6ZVX9,Membrane progestin receptor epsilon OS=Homo sapiens OX=9606 GN=PAQR9 PE=1 SV=1,0.003,6.417,4,1,4,1,377,42.7,8.59,2559,,1,,regulation of biological process;response to stimulus,membrane,receptor activity;signal transducer activity,Pf03006,344838,ENSG00000188582.8,PAQR9,3,,,,0,High,1
P43405,Tyrosine-protein kinase SYK OS=Homo sapiens OX=9606 GN=SYK PE=1 SV=1,0.003,6.414,5,3,9,3,635,72,8.25,2557,,3,,cell proliferation;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding;signal transducer activity,"Pf00017, Pf00069, Pf07714",6850,ENSG00000165025.14,SYK,9,PI3K-Akt signaling pathway; Tuberculosis; B cell receptor signaling pathway; Osteoclast differentiation; Fc gamma R-mediated phagocytosis; NF-kappa B signaling pathway; Epstein-Barr virus infection; Viral carcinogenesis; Platelet activation; Fc epsilon RI signaling pathway; Natural killer cell mediated cytotoxicity; Phospholipase D signaling pathway,IL-5 Signaling Pathway; Regulation of toll-like receptor signaling pathway; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; B Cell Receptor Signaling Pathway; IL-3 Signaling Pathway; Microglia Pathogen Phagocytosis Pathway; IL-2 Signaling Pathway,FCERI mediated Ca+2 mobilization; Dectin-2 family; Integrin alphaIIb beta3 signaling; FCERI mediated MAPK activation; DAP12 signaling; Regulation of signaling by CBL; GPVI-mediated activation cascade; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Interleukin-2 family signaling; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; CLEC7A (Dectin-1) signaling; Role of phospholipids in phagocytosis,49,High,1
O95551,Tyrosyl-DNA phosphodiesterase 2 OS=Homo sapiens OX=9606 GN=TDP2 PE=1 SV=1,0.003,6.414,6,2,4,2,362,40.9,5.1,1460,,2,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,catalytic activity;DNA binding;metal ion binding;protein binding,"Pf03372, Pf14555",51567,ENSG00000111802.13,TDP2,6,,Oxidative Damage,Nonhomologous End-Joining (NHEJ),4,High,1
Q9H4A6,Golgi phosphoprotein 3 OS=Homo sapiens OX=9606 GN=GOLPH3 PE=1 SV=1,0.003,6.41,5,1,4,1,298,33.8,6.44,1833,,1,,cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process;transport,cytosol;endosome;Golgi;membrane;mitochondrion,protein binding,Pf05719,64083,ENSG00000113384.13,GOLPH3,5,Transcriptional misregulation in cancer,,,1,High,1
Q92466,DNA damage-binding protein 2 OS=Homo sapiens OX=9606 GN=DDB2 PE=1 SV=1,0.003,6.401,4,2,4,2,427,47.8,9.47,1378,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,nucleus,catalytic activity;DNA binding;protein binding,Pf00400,1643,ENSG00000134574.11,DDB2,11,p53 signaling pathway; Ubiquitin mediated proteolysis; Nucleotide excision repair; Hepatitis B,miRNA Regulation of DNA Damage Response; DNA Damage Response,Ub-specific processing proteases; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; TP53 Regulates Transcription of DNA Repair Genes; Dual Incision in GG-NER; Neddylation,22,High,1
O00182,Galectin-9 OS=Homo sapiens OX=9606 GN=LGALS9 PE=1 SV=2,0.003,6.397,4,1,7,1,355,39.5,9.17,3104,,1,,cell differentiation;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;extracellular;nucleus,protein binding;signal transducer activity,Pf00337,3965,ENSG00000168961.16,LGALS9,17,,,Interleukin-2 family signaling,4,High,1
Q8WUA2,Peptidyl-prolyl cis-trans isomerase-like 4 OS=Homo sapiens OX=9606 GN=PPIL4 PE=1 SV=1,0.003,6.396,3,1,3,1,492,57.2,5.92,1320,,1,,metabolic process;regulation of biological process,cytosol;nucleus,catalytic activity;RNA binding,"Pf00076, Pf00160, Pf13893, Pf14259",85313,ENSG00000131013.3,PPIL4,6,,,mRNA Splicing - Major Pathway,4,High,1
P63146,Ubiquitin-conjugating enzyme E2 B OS=Homo sapiens OX=9606 GN=UBE2B PE=1 SV=1,0.003,6.392,11,1,7,1,152,17.3,5.01,3031,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;membrane;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00179, Pf14461",7320,ENSG00000119048.7,UBE2B,5,Ubiquitin mediated proteolysis,Proteasome Degradation,Synthesis of active ubiquitin: roles of E1 and E2 enzymes; E3 ubiquitin ligases ubiquitinate target proteins; Antigen processing: Ubiquitination & Proteasome degradation; Recognition of DNA damage by PCNA-containing replication complex,14,High,1
Q8IX07,Zinc finger protein ZFPM1 OS=Homo sapiens OX=9606 GN=ZFPM1 PE=1 SV=2,0.003,6.374,1,1,4,1,1006,104.8,7.87,2809,,1,,cell differentiation;cell organization and biogenesis;coagulation;metabolic process;regulation of biological process,cytoplasm;nucleus,DNA binding;metal ion binding;protein binding,"Pf13465, Pf13912",161882,ENSG00000179588.8,ZFPM1,16,,,RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Factors involved in megakaryocyte development and platelet production,7,High,1
Q8TB03,Uncharacterized protein CXorf38 OS=Homo sapiens OX=9606 GN=CXorf38 PE=1 SV=1,0.003,6.374,8,3,48,3,319,36.6,6.3,18745,,3,,,,,Pf15112,159013,ENSG00000185753.12,CXorf38,X,,,,0,High,1
Q9NQY0,Bridging integrator 3 OS=Homo sapiens OX=9606 GN=BIN3 PE=1 SV=1,0.003,6.373,15,3,6,3,253,29.6,7.47,1778,,3,,cell division;cell growth;cell organization and biogenesis;cellular component movement;regulation of biological process,cytoplasm;cytoskeleton,protein binding,Pf03114,55909,ENSG00000147439.12,BIN3,8,,,,0,High,1
Q9H8Y5,Ankyrin repeat and zinc finger domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ANKZF1 PE=1 SV=1,0.003,6.371,7,3,48,3,726,80.9,8.41,13973,,3,,metabolic process;response to stimulus,cytoplasm;membrane,catalytic activity;metal ion binding;protein binding,"Pf00023, Pf12796",55139,ENSG00000163516.13,ANKZF1,2,,,,0,High,1
Q86WX3,Active regulator of SIRT1 OS=Homo sapiens OX=9606 GN=RPS19BP1 PE=1 SV=1,0.003,6.358,25,3,9,3,136,15.4,10.74,2649,,3,,,cytosol;nucleus;ribosome,protein binding;RNA binding,,91582,ENSG00000187051.8,RPS19BP1,22,,,Regulation of HSF1-mediated heat shock response,4,High,1
Q8TEJ3,E3 ubiquitin-protein ligase SH3RF3 OS=Homo sapiens OX=9606 GN=SH3RF3 PE=1 SV=2,0.003,6.357,2,2,58,2,882,92.7,8.84,31100,,2,,metabolic process;regulation of biological process,,metal ion binding;protein binding,"Pf00018, Pf00097, Pf03153, Pf05109, Pf07653, Pf11593, Pf13445, Pf13639, Pf13923, Pf14604, Pf14634, Pf15227",344558,ENSG00000172985.10,SH3RF3,2,,,,0,High,1
Q14511,Enhancer of filamentation 1 OS=Homo sapiens OX=9606 GN=NEDD9 PE=1 SV=1,0.003,6.356,2,2,6,1,834,92.8,6.7,2142,,2,,cell division;cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;Golgi;membrane;nucleus,protein binding,"Pf00018, Pf07653, Pf08824, Pf12026, Pf14604",4739,ENSG00000111859.16,NEDD9,6,,TGF-beta Signaling Pathway,,1,High,1
Q5T5C0,Syntaxin-binding protein 5 OS=Homo sapiens OX=9606 GN=STXBP5 PE=1 SV=1,0.003,6.349,2,2,4,2,1151,127.5,7.28,1444,,2,,regulation of biological process;transport,cytoplasm;cytosol;membrane,enzyme regulator activity;protein binding,"Pf00400, Pf00957, Pf08366",134957,ENSG00000164506.14,STXBP5,6,,,,0,High,1
Q14644,Ras GTPase-activating protein 3 OS=Homo sapiens OX=9606 GN=RASA3 PE=1 SV=3,0.003,6.346,2,2,5,2,834,95.6,7.15,2300,,2,,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane,enzyme regulator activity;metal ion binding;protein binding;transporter activity,"Pf00168, Pf00169, Pf00616, Pf00779",22821,ENSG00000280477.1; ENSG00000185989.10,RASA3,13; CHR_HG2288_HG2289_PATCH,Ras signaling pathway,MAPK Cascade,Regulation of RAS by GAPs; Signaling by RAS mutants; Interleukin-20 family signaling,15,High,1
Q8IWB7,WD repeat and FYVE domain-containing protein 1 OS=Homo sapiens OX=9606 GN=WDFY1 PE=1 SV=1,0.003,6.335,6,2,7,2,410,46.3,7.33,1978,,2,,regulation of biological process,cytosol;endosome;nucleus,metal ion binding;protein binding,"Pf00400, Pf01363",57590,ENSG00000085449.14,WDFY1,2,,,,0,High,1
Q9NVV5,Androgen-induced gene 1 protein OS=Homo sapiens OX=9606 GN=AIG1 PE=1 SV=2,0.003,6.331,6,1,7,1,245,28.2,8.25,2290,,1,,,membrane,protein binding,Pf04750,51390,ENSG00000146416.17,AIG1,6,,,,0,High,1
Q96FN9,D-aminoacyl-tRNA deacylase 2 OS=Homo sapiens OX=9606 GN=DTD2 PE=1 SV=1,0.003,6.327,13,1,4,1,168,18.6,7.84,1535,,1,,metabolic process;regulation of biological process,cytoplasm,catalytic activity;protein binding,Pf02580,112487,ENSG00000129480.12,DTD2,14,,,,0,High,1
Q6PIJ6,F-box only protein 38 OS=Homo sapiens OX=9606 GN=FBXO38 PE=1 SV=3,0.003,6.292,2,2,4,2,1188,133.9,6.33,1453,,2,,regulation of biological process,cytoplasm;nucleus,protein binding,"Pf00646, Pf12937",81545,ENSG00000145868.16,FBXO38,5,,,,0,High,1
Q9NYZ1,Golgi apparatus membrane protein TVP23 homolog B OS=Homo sapiens OX=9606 GN=TVP23B PE=1 SV=2,0.003,6.289,6,1,1,1,205,23.6,8.35,501,,1,,transport,membrane,,Pf05832,51030,ENSG00000171928.13,FAM18B1; TVP23B,17,,,,0,High,1
Q04864,Proto-oncogene c-Rel OS=Homo sapiens OX=9606 GN=REL PE=1 SV=1,0.003,6.279,4,2,4,2,619,68.5,5.86,1784,,2,,defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,DNA binding;protein binding,Pf00554,5966,ENSG00000162924.13,REL,2,Viral carcinogenesis; Transcriptional misregulation in cancer; Ras signaling pathway,IL-1 signaling pathway; Leptin signaling pathway; B Cell Receptor Signaling Pathway; TNF alpha Signaling Pathway; Photodynamic therapy-induced NF-kB survival signaling; Toll-like Receptor Signaling; Interferon type I signaling pathways; T-Cell antigen Receptor (TCR)  Signaling Pathway,Activation of NF-kappaB in B cells,16,High,1
Q16563,Synaptophysin-like protein 1 OS=Homo sapiens OX=9606 GN=SYPL1 PE=1 SV=1,0.003,6.277,4,1,31,1,259,28.5,8.43,13985,,1,,cell communication;transport,membrane,transporter activity,Pf01284,6856,ENSG00000008282.8,SYPL1,7,,,,0,High,1
Q96QA5,Gasdermin-A OS=Homo sapiens OX=9606 GN=GSDMA PE=1 SV=4,0.003,6.272,5,2,4,2,445,49.3,5.29,2118,,2,,cell death,cytoplasm;cytosol;membrane,,Pf04598,284110,ENSG00000167914.11,GSDMA,17,,,,0,High,1
Q96S90,LysM and putative peptidoglycan-binding domain-containing protein 1 OS=Homo sapiens OX=9606 GN=LYSMD1 PE=1 SV=1,0.003,6.268,12,1,1,1,227,25,8.57,406,,1,,,,protein binding,Pf01476,388695,ENSG00000163155.11,LYSMD1,1,,,,0,High,1
Q9BSB4,Autophagy-related protein 101 OS=Homo sapiens OX=9606 GN=ATG101 PE=1 SV=1,0.003,6.267,8,1,3,1,218,25,6.15,1673,,1,,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,protein binding,Pf07855,60673,ENSG00000123395.14,C12orf44; ATG101,12,Longevity regulating pathway,,Macroautophagy,3,High,1
P78536,Disintegrin and metalloproteinase domain-containing protein 17 OS=Homo sapiens OX=9606 GN=ADAM17 PE=1 SV=1,0.003,6.264,3,2,7,2,824,93,5.76,2137,,2,,cell differentiation;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus,cell surface;cytoplasm;cytoskeleton;cytosol;membrane,catalytic activity;metal ion binding;protein binding,"Pf00200, Pf01421, Pf01562, Pf13574, Pf13582, Pf13583, Pf13688",6868,ENSG00000151694.12,ADAM17,2,Notch signaling pathway; Alzheimer's disease; Epithelial cell signaling in Helicobacter pylori infection,Alzheimers Disease; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Notch Signaling Pathway; Copper homeostasis; Notch Signaling Pathway,Collagen degradation; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant; Regulated proteolysis of p75NTR; Release of Hh-Np from the secreting cell; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; TNF signaling; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Nuclear signaling by ERBB4; Constitutive Signaling by NOTCH1 HD Domain Mutants; Signalling by NGF; Growth hormone receptor signaling; Signaling by EGFR,41,High,1
P01743,Immunoglobulin heavy variable 1-46 OS=Homo sapiens OX=9606 GN=IGHV1-46 PE=1 SV=2,0.003,6.259,23,2,4,1,117,12.9,8.92,1097,,2,,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane,catalytic activity,,28465,ENSG00000211962.2; ENSG00000282131.1,IGHV1-46,14; CHR_HSCHR14_3_CTG1,,,FCERI mediated Ca+2 mobilization; Scavenging of heme from plasma; Classical antibody-mediated complement activation; FCERI mediated MAPK activation; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Regulation of Complement cascade; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of LAT2/NTAL/LAB on calcium mobilization; Role of phospholipids in phagocytosis,26,High,1
Q96IG2,F-box/LRR-repeat protein 20 OS=Homo sapiens OX=9606 GN=FBXL20 PE=1 SV=2,0.003,6.256,3,1,1,1,436,48.4,7.49,726,,1,,defense response;metabolic process;response to stimulus,cytoplasm;cytosol,catalytic activity;protein binding,"Pf00646, Pf12937",84961,ENSG00000108306.11,FBXL20,17,,,Antigen processing: Ubiquitination & Proteasome degradation; Neddylation,7,High,1
P49069,Calcium signal-modulating cyclophilin ligand OS=Homo sapiens OX=9606 GN=CAMLG PE=1 SV=1,0.003,6.248,9,2,2,2,296,32.9,8.05,656,,2,,defense response;metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;membrane,protein binding,Pf14963,819,ENSG00000164615.4,CAMLG,5,,,,0,High,1
P55285,Cadherin-6 OS=Homo sapiens OX=9606 GN=CDH6 PE=1 SV=1,0.003,6.235,2,2,4,2,790,88.3,4.93,1743,,2,,cell organization and biogenesis;regulation of biological process;response to stimulus,membrane,metal ion binding,"Pf00028, Pf01049",1004,ENSG00000113361.12,CDH6,5,,Neural Crest Differentiation; Ectoderm Differentiation; TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition,Adherens junctions interactions,7,High,1
O00623,Peroxisome assembly protein 12 OS=Homo sapiens OX=9606 GN=PEX12 PE=1 SV=1,0.003,6.228,9,2,9,2,359,40.8,9.11,2957,,2,,cell organization and biogenesis;metabolic process;transport,membrane,catalytic activity;metal ion binding;protein binding,"Pf00097, Pf04757, Pf13639, Pf13923",5193,ENSG00000108733.9,PEX12,17,Peroxisome,,E3 ubiquitin ligases ubiquitinate target proteins,5,High,1
Q9Y496,Kinesin-like protein KIF3A OS=Homo sapiens OX=9606 GN=KIF3A PE=1 SV=4,0.003,6.227,3,2,23,1,699,80,6.54,8378,,2,,cell differentiation;cell organization and biogenesis;cellular component movement;transport,cytoplasm;cytoskeleton;cytosol,catalytic activity;motor activity;nucleotide binding;protein binding,"Pf00225, Pf03938",11127,ENSG00000131437.15,KIF3A,5,Hedgehog signaling pathway,Endochondral Ossification; Insulin Signaling,Translocation of GLUT4 to the plasma membrane; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; Activation of SMO; Intraflagellar transport; MHC class II antigen presentation; Hedgehog 'off' state,23,High,1
P08473,Neprilysin OS=Homo sapiens OX=9606 GN=MME PE=1 SV=2,0.003,6.224,3,2,24,1,750,85.5,5.73,10980,,2,,metabolic process;response to stimulus;transport,cytoplasm;membrane,catalytic activity;metal ion binding;protein binding,"Pf01431, Pf05649",4311,ENSG00000196549.10,MME,3,Protein digestion and absorption; Alzheimer's disease; Renin-angiotensin system; Hematopoietic cell lineage,Alzheimers Disease; Primary Focal Segmental Glomerulosclerosis FSGS,Metabolism of Angiotensinogen to Angiotensins; Neutrophil degranulation,12,High,1
Q13572,Inositol-tetrakisphosphate 1-kinase OS=Homo sapiens OX=9606 GN=ITPK1 PE=1 SV=2,0.003,6.222,5,1,4,1,414,45.6,6.16,1400,,1,,coagulation;metabolic process;regulation of biological process;response to stimulus,cytosol;membrane,catalytic activity;metal ion binding;nucleotide binding,Pf05770,3705,ENSG00000274958.4; ENSG00000100605.16,ITPK1,14; CHR_HSCHR14_7_CTG1,Phosphatidylinositol signaling system; Metabolic pathways; Inositol phosphate metabolism,,Synthesis of IP3 and IP4 in the cytosol; Synthesis of pyrophosphates in the cytosol; Factors involved in megakaryocyte development and platelet production,9,High,1
P09132,Signal recognition particle 19 kDa protein OS=Homo sapiens OX=9606 GN=SRP19 PE=1 SV=3,0.003,6.219,19,2,2,2,144,16.1,9.85,829,,2,,cell organization and biogenesis;response to stimulus;transport,cytoplasm;cytosol,protein binding;RNA binding,Pf01922,6728,ENSG00000153037.13,SRP19,5,Protein export,,SRP-dependent cotranslational protein targeting to membrane,4,High,1
P02686,Myelin basic protein OS=Homo sapiens OX=9606 GN=MBP PE=1 SV=3,0.003,6.218,3,1,3,1,304,33.1,9.79,1896,,1,,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,membrane;nucleus,protein binding;structural molecule activity,Pf01669,4155,ENSG00000197971.14,MBP,18,,Neural Crest Differentiation; Glial Cell Differentiation; Spinal Cord Injury; Structural Pathway of Interleukin 1 (IL-1); Mecp2 and Associated Rett Syndrome; MAPK Cascade,,6,High,1
P50238,Cysteine-rich protein 1 OS=Homo sapiens OX=9606 GN=CRIP1 PE=1 SV=3,0.003,6.215,9,1,55,1,77,8.5,8.75,30046,,1,,cell proliferation;regulation of biological process;response to stimulus,cytoplasm,DNA binding;metal ion binding,Pf00412,1396,ENSG00000257341.5; ENSG00000213145.9,CRIP1,14,,,,0,High,1
Q9UKB1,F-box/WD repeat-containing protein 11 OS=Homo sapiens OX=9606 GN=FBXW11 PE=1 SV=1,0.003,6.211,4,1,3,1,542,62.1,7.12,1380,,1,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,"Pf00400, Pf00646, Pf08801, Pf12125, Pf12937",23291,ENSG00000072803.17,FBXW11,5,Circadian rhythm; Hippo signaling pathway; Oocyte meiosis; Shigellosis; Hedgehog signaling pathway; Wnt signaling pathway; Ubiquitin mediated proteolysis,TNF alpha Signaling Pathway; VEGFA-VEGFR2 Signaling Pathway,Downstream TCR signaling; Regulation of PLK1 Activity at G2/M Transition; NIK-->noncanonical NF-kB signaling; MAP3K8 (TPL2)-dependent MAPK1/3 activation; Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Neddylation; Activated TLR4 signalling; Interleukin-1 family signaling; Activation of NF-kappaB in B cells; Dectin-1 mediated noncanonical NF-kB signaling,57,High,1
O14647,Chromodomain-helicase-DNA-binding protein 2 OS=Homo sapiens OX=9606 GN=CHD2 PE=1 SV=2,0.003,6.209,2,3,13,2,1828,211.2,8.1,4428,,3,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding;RNA binding,"Pf00176, Pf00271, Pf00385, Pf04851, Pf11496, Pf13907",1106,ENSG00000173575.20,CHD2,15,,,,0,High,1
O60906,Sphingomyelin phosphodiesterase 2 OS=Homo sapiens OX=9606 GN=SMPD2 PE=1 SV=2,0.003,6.208,4,1,3,1,423,47.6,6.98,982,,1,,metabolic process;regulation of biological process;response to stimulus,membrane,catalytic activity;metal ion binding,Pf03372,6610,ENSG00000135587.8,SMPD2,6,Sphingolipid signaling pathway; Metabolic pathways; Sphingolipid metabolism,TNF alpha Signaling Pathway; Signal Transduction of S1P Receptor,Glycosphingolipid metabolism; Ceramide signalling; TNFR1-mediated ceramide production; Signalling by NGF,17,High,1
O95071,E3 ubiquitin-protein ligase UBR5 OS=Homo sapiens OX=9606 GN=UBR5 PE=1 SV=2,0.003,6.207,1,2,9,2,2799,309.2,5.85,2520,,2,,cell proliferation;metabolic process;regulation of biological process;response to stimulus,cytosol;membrane;nucleus,catalytic activity;metal ion binding;protein binding;RNA binding,"Pf00632, Pf00658, Pf02207, Pf11547",51366,ENSG00000104517.12,UBR5,8,Ubiquitin mediated proteolysis,Mesodermal Commitment Pathway; Tryptophan metabolism,,3,High,1
Q96P11,Probable 28S rRNA (cytosine-C(5))-methyltransferase OS=Homo sapiens OX=9606 GN=NSUN5 PE=1 SV=2,0.003,6.206,6,2,4,2,429,46.7,8.62,1302,,2,,metabolic process,nucleus,catalytic activity;RNA binding,Pf01189,55695,ENSG00000130305.16,NSUN5,7,,,,0,High,1
P22891,Vitamin K-dependent protein Z OS=Homo sapiens OX=9606 GN=PROZ PE=1 SV=2,0.003,6.204,3,1,1,1,400,44.7,5.97,852,,1,,coagulation;metabolic process;regulation of biological process;transport,extracellular;organelle lumen,catalytic activity;metal ion binding;protein binding,"Pf00008, Pf00089, Pf00594, Pf12662, Pf14670",8858,ENSG00000126231.13,PROZ,13,,,Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus; Removal of aminoterminal propeptides from gamma-carboxylated proteins; Gamma-carboxylation of protein precursors,7,High,1
Q9NQ84,G-protein coupled receptor family C group 5 member C OS=Homo sapiens OX=9606 GN=GPRC5C PE=1 SV=2,0.003,6.195,5,2,3,2,441,48.2,8.43,733,,2,,regulation of biological process;response to stimulus,membrane,receptor activity;signal transducer activity,Pf00003,55890,,GPRC5C,17,,"GPCRs, Class C Metabotropic glutamate, pheromone",,1,High,1
Q9Y303,N-acetylglucosamine-6-phosphate deacetylase OS=Homo sapiens OX=9606 GN=AMDHD2 PE=1 SV=2,0.003,6.195,5,1,6,1,409,43.7,6.7,2044,,1,,metabolic process,cytosol;nucleus,catalytic activity;metal ion binding;protein binding,"Pf01979, Pf07969, Pf13147, Pf13594",51005,ENSG00000162066.14,AMDHD2,16,Amino sugar and nucleotide sugar metabolism,,Synthesis of UDP-N-acetyl-glucosamine,7,High,1
Q14457,Beclin-1 OS=Homo sapiens OX=9606 GN=BECN1 PE=1 SV=2,0.003,6.18,4,2,6,2,450,51.9,4.89,2050,,2,,cell communication;cell death;cell division;cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;endosome;Golgi;membrane;mitochondrion;nucleus;vacuole,protein binding,"Pf04111, Pf12777, Pf13851, Pf15285",8678,ENSG00000126581.12,BECN1,17,Autophagy; Apoptosis - multiple species,Nanoparticle triggered autophagic cell death; Senescence and Autophagy in Cancer,Ub-specific processing proteases; Macroautophagy; Interleukin-7 signaling,14,High,1
Q9NPB1,"5'(3')-deoxyribonucleotidase, mitochondrial OS=Homo sapiens OX=9606 GN=NT5M PE=1 SV=1",0.003,6.177,6,1,2,1,228,25.8,8,,4.82,,1,metabolic process,mitochondrion;organelle lumen,catalytic activity;metal ion binding;nucleotide binding;receptor activity;signal transducer activity,Pf06941,56953,ENSG00000205309.13,NT5M,17,Pyrimidine metabolism; Nicotinate and nicotinamide metabolism; Metabolic pathways; Purine metabolism,,Pyrimidine catabolism,8,High,1
Q9NWH2,Transmembrane protein 242 OS=Homo sapiens OX=9606 GN=TMEM242 PE=1 SV=1,0.003,6.174,15,2,10,2,141,14.7,9.11,3138,,2,,,membrane,protein binding,Pf07096,729515,ENSG00000215712.10,TMEM242,6,,,,0,High,1
Q9NPP4,NLR family CARD domain-containing protein 4 OS=Homo sapiens OX=9606 GN=NLRC4 PE=1 SV=2,0.003,6.166,1,2,11,2,1024,116.1,6.77,3654,,2,,cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus,catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding,"Pf00619, Pf05729",58484,ENSG00000091106.18,NLRC4,2,NOD-like receptor signaling pathway; Salmonella infection; Legionellosis,Nucleotide-binding Oligomerization Domain (NOD) pathway,The IPAF inflammasome; TP53 Regulates Transcription of Caspase Activators and Caspases,15,High,1
Q9NVC3,Putative sodium-coupled neutral amino acid transporter 7 OS=Homo sapiens OX=9606 GN=SLC38A7 PE=1 SV=1,0.003,6.16,5,2,5,2,462,49.9,5.08,1605,,2,,transport,membrane,protein binding;transporter activity,"Pf01490, Pf03845",55238,ENSG00000103042.8,SLC38A7,16,,,,0,High,1
Q504Q3,PAN2-PAN3 deadenylation complex catalytic subunit PAN2 OS=Homo sapiens OX=9606 GN=PAN2 PE=1 SV=3,0.003,6.155,2,2,2,2,1202,135.3,5.99,704,,2,,metabolic process,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;protein binding,"Pf00443, Pf00929, Pf13423",9924,ENSG00000135473.14,PAN2,12,RNA degradation,Ectoderm Differentiation,Deadenylation of mRNA,5,High,1
O60760,Hematopoietic prostaglandin D synthase OS=Homo sapiens OX=9606 GN=HPGDS PE=1 SV=3,0.003,6.151,10,1,5,1,199,23.3,5.85,1797,,1,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,catalytic activity;metal ion binding;protein binding,"Pf00043, Pf02798, Pf13409, Pf13417",27306,ENSG00000163106.10,HPGDS,4,Arachidonic acid metabolism; Chemical carcinogenesis; Glutathione metabolism; Metabolic pathways; Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450,Aryl Hydrocarbon Receptor,Glutathione conjugation; Synthesis of Prostaglandins (PG) and Thromboxanes (TX),15,High,1
A6NED2,RCC1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RCCD1 PE=1 SV=1,0.003,6.143,5,1,4,1,376,40.1,5.27,1693,,1,,cell organization and biogenesis,chromosome;cytosol;membrane,,"Pf00415, Pf13540",91433,ENSG00000166965.12,RCCD1,15,,,,0,High,1
Q00613,Heat shock factor protein 1 OS=Homo sapiens OX=9606 GN=HSF1 PE=1 SV=1,0.003,6.131,3,1,4,1,529,57.2,5.19,1327,,1,,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,chromosome;cytoplasm;cytoskeleton;cytosol;nucleus,DNA binding;protein binding,"Pf00447, Pf06546",3297,ENSG00000185122.10,HSF1,8,Legionellosis,,Attenuation phase; HSF1 activation; Regulation of HSF1-mediated heat shock response,8,High,1
Q01432,AMP deaminase 3 OS=Homo sapiens OX=9606 GN=AMPD3 PE=1 SV=1,0.003,6.131,3,2,5,2,767,88.8,6.98,1380,,2,,metabolic process;transport,cytosol;extracellular;organelle lumen,catalytic activity;metal ion binding;protein binding,Pf00962,272,ENSG00000133805.15,AMPD3,11,Purine metabolism; Metabolic pathways,,Neutrophil degranulation; Purine salvage,9,High,1
P47974,mRNA decay activator protein ZFP36L2 OS=Homo sapiens OX=9606 GN=ZFP36L2 PE=1 SV=3,0.003,6.13,4,1,2,1,494,51,8.16,647,,1,,cell differentiation;cell division;cell proliferation;development;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,DNA binding;metal ion binding;protein binding;RNA binding,"Pf00642, Pf04553",678,ENSG00000152518.7,ZFP36L2,2,,Preimplantation Embryo; TYROBP Causal Network,,2,High,1
P24390,ER lumen protein-retaining receptor 1 OS=Homo sapiens OX=9606 GN=KDELR1 PE=1 SV=1,0.003,6.127,9,1,3,1,212,24.5,8.62,1210,,1,,cell death;cell differentiation;response to stimulus;transport,endoplasmic reticulum;Golgi;membrane,,Pf00810,10945,ENSG00000105438.8,KDELR1,19,Vibrio cholerae infection,,COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport,12,High,1
O43909,Exostosin-like 3 OS=Homo sapiens OX=9606 GN=EXTL3 PE=1 SV=1,0.003,6.121,2,1,4,1,919,104.7,6.51,1491,,1,,metabolic process;regulation of biological process;transport,endoplasmic reticulum;Golgi;membrane,catalytic activity;metal ion binding;receptor activity,"Pf02403, Pf03016, Pf07926, Pf09258, Pf11559",2137,ENSG00000012232.8,EXTL3,8,Glycosaminoglycan biosynthesis - heparan sulfate / heparin; Metabolic pathways,,XBP1(S) activates chaperone genes,6,High,1
Q9BXR6,Complement factor H-related protein 5 OS=Homo sapiens OX=9606 GN=CFHR5 PE=1 SV=1,0.003,6.116,3,2,6,2,569,64.4,7.06,2331,,2,,defense response;metabolic process;regulation of biological process;response to stimulus,extracellular,protein binding,Pf00084,81494,ENSG00000134389.9,CFHR5,1,,,Regulation of Complement cascade,4,High,1
O75427,Leucine-rich repeat and calponin homology domain-containing protein 4 OS=Homo sapiens OX=9606 GN=LRCH4 PE=1 SV=2,0.003,6.115,6,2,2,2,683,73.4,8.22,698,,2,,regulation of biological process;response to stimulus,cytoplasm;membrane,protein binding,"Pf00307, Pf11971, Pf12799, Pf13855",4034,ENSG00000077454.15,LRCH4,7,,,,0,High,1
Q13268,"Dehydrogenase/reductase SDR family member 2, mitochondrial OS=Homo sapiens OX=9606 GN=DHRS2 PE=1 SV=4",0.003,6.107,5,2,42,2,280,29.9,9.01,20208,,2,,cell differentiation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;mitochondrion;nucleus;organelle lumen,catalytic activity;protein binding,"Pf00106, Pf08659, Pf13561",10202,ENSG00000100867.14,DHRS2,14,,,,0,High,1
P78362,SRSF protein kinase 2 OS=Homo sapiens OX=9606 GN=SRPK2 PE=1 SV=3,0.003,6.105,2,1,6,1,688,77.5,4.97,2843,,1,,cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding,"Pf00069, Pf07714",6733,ENSG00000135250.16,SRPK2,7,,mRNA Processing,,1,High,1
Q9UM47,Neurogenic locus notch homolog protein 3 OS=Homo sapiens OX=9606 GN=NOTCH3 PE=1 SV=2,0.003,6.099,1,2,2,2,2321,243.5,5.39,658,,2,,cell differentiation;development;metabolic process;regulation of biological process;response to stimulus,cytoskeleton;cytosol;extracellular;membrane;nucleus,metal ion binding;protein binding;receptor activity,"Pf00008, Pf00023, Pf00066, Pf06816, Pf07645, Pf07684, Pf11936, Pf12796, Pf12947, Pf13606, Pf13637, Pf13857",4854,ENSG00000074181.8,NOTCH3,19,MicroRNAs in cancer; Notch signaling pathway; Th1 and Th2 cell differentiation; Breast cancer; Dorso-ventral axis formation; Endocrine resistance; Thyroid hormone signaling pathway,Neural Crest Differentiation; Notch Signaling Pathway; Canonical  and Non-canonical Notch signaling; Role of Osx and miRNAs in tooth development; Notch Signaling Pathway,Defective LFNG causes SCDO3; Pre-NOTCH Processing in Golgi; Notch-HLH transcription pathway; Pre-NOTCH Transcription and Translation; Signaling by NOTCH3; Pre-NOTCH Processing in the Endoplasmic Reticulum,27,High,1
Q2TAL5,Smoothelin-like protein 2 OS=Homo sapiens OX=9606 GN=SMTNL2 PE=2 SV=1,0.003,6.097,5,2,5,2,461,50.2,8.56,312,8.17,1,1,,,protein binding,"Pf00307, Pf11971",342527,ENSG00000188176.11,SMTNL2,17,,,,0,High,1
Q13332,Receptor-type tyrosine-protein phosphatase S OS=Homo sapiens OX=9606 GN=PTPRS PE=1 SV=3,0.003,6.083,1,2,6,2,1948,216.9,6.46,1757,,2,,metabolic process;regulation of biological process,membrane,catalytic activity;protein binding,"Pf00041, Pf00047, Pf00102, Pf07679, Pf09294, Pf13895, Pf13927, Pf14566",5802,ENSG00000105426.16,PTPRS,19,,,ECM proteoglycans; Receptor-type tyrosine-protein phosphatases; Synaptic adhesion-like molecules,6,High,1
A9UHW6,MIF4G domain-containing protein OS=Homo sapiens OX=9606 GN=MIF4GD PE=1 SV=1,0.003,6.077,9,2,8,2,222,25.4,5.33,2674,,2,,regulation of biological process,cytoplasm;cytosol;nucleus,protein binding;RNA binding,Pf02854,57409,ENSG00000125457.13,MIF4GD,17,,,,0,High,1
Q04941,Proteolipid protein 2 OS=Homo sapiens OX=9606 GN=PLP2 PE=1 SV=1,0.003,6.067,9,1,5,1,152,16.7,7.24,2637,,1,,regulation of biological process;response to stimulus;transport,endoplasmic reticulum;membrane,protein binding;transporter activity,Pf01284,5355,ENSG00000102007.10,PLP2,X,,,,0,High,1
Q9P2N5,RNA-binding protein 27 OS=Homo sapiens OX=9606 GN=RBM27 PE=1 SV=2,0.003,6.062,2,2,5,2,1060,118.6,9.19,1743,,2,,metabolic process,cytoplasm;nucleus,metal ion binding;RNA binding,"Pf00076, Pf00642, Pf03962, Pf13893, Pf14259",54439,ENSG00000091009.7,RBM27,5,,,,0,High,1
P16860,Natriuretic peptides B OS=Homo sapiens OX=9606 GN=NPPB PE=1 SV=1,0.003,6.054,16,1,1,1,134,14.7,10.33,360,,1,,cell growth;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;extracellular;nucleus,protein binding,Pf00212,4879,ENSG00000120937.8,NPPB,1,cGMP-PKG signaling pathway,MicroRNAs in cardiomyocyte hypertrophy,,2,High,1
Q8TBF2,Prostamide/prostaglandin F synthase OS=Homo sapiens OX=9606 GN=PRXL2B PE=1 SV=1,0.003,6.041,10,1,3,1,198,21.2,6.67,1191,,1,,metabolic process,cytoplasm;cytosol;endoplasmic reticulum,antioxidant activity;catalytic activity;nucleotide binding,"Pf00152, Pf13911",127281,,FAM213B,1,Metabolic pathways; Arachidonic acid metabolism,,Synthesis of Prostaglandins (PG) and Thromboxanes (TX),7,High,1
Q8WUY3,Protein prune homolog 2 OS=Homo sapiens OX=9606 GN=PRUNE2 PE=1 SV=3,0.003,6.04,1,2,11,2,3088,340.4,4.45,3738,,2,,cell death,cytoplasm,catalytic activity;metal ion binding,"Pf02833, Pf12496, Pf13716",158471,ENSG00000106772.17,PRUNE2,9,,,,0,High,1
Q9UBT7,Alpha-catulin OS=Homo sapiens OX=9606 GN=CTNNAL1 PE=1 SV=2,0.003,6.038,2,1,3,1,734,81.8,6.64,1130,,1,,regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane,protein binding,Pf01044,8727,ENSG00000119326.14,CTNNAL1,9,,Regulation of toll-like receptor signaling pathway,,1,High,1
P13726,Tissue factor OS=Homo sapiens OX=9606 GN=F3 PE=1 SV=1,0.003,6.035,11,2,9,2,295,33,7.03,2667,0,2,1,coagulation;metabolic process;regulation of biological process;response to stimulus,cell surface;extracellular;membrane,catalytic activity;protein binding;receptor activity;signal transducer activity,"Pf01108, Pf09294",2152,ENSG00000117525.13,F3,1,AGE-RAGE signaling pathway in diabetic complications; Complement and coagulation cascades,VEGFA-VEGFR2 Signaling Pathway; Complement and Coagulation Cascades,Extrinsic Pathway of Fibrin Clot Formation,7,High,1
P15291,"Beta-1,4-galactosyltransferase 1 OS=Homo sapiens OX=9606 GN=B4GALT1 PE=1 SV=5",0.003,6.025,5,2,3,2,398,43.9,8.65,1020,,2,,cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;extracellular;Golgi;membrane,catalytic activity;metal ion binding;protein binding,"Pf02709, Pf10111, Pf13733",2683,ENSG00000086062.12,B4GALT1,9,Glycosphingolipid biosynthesis - lacto and neolacto series; Metabolic pathways; Galactose metabolism; N-Glycan biosynthesis; Glycosaminoglycan biosynthesis - keratan sulfate; Other types of O-glycan biosynthesis,,Pre-NOTCH Processing in Golgi; Defective B4GALT1 causes B4GALT1-CDG (CDG-2d); N-Glycan antennae elongation; Lactose synthesis; Neutrophil degranulation; Keratan sulfate biosynthesis; Interaction With The Zona Pellucida; Defective B4GALT1 causes B4GALT1-CDG (CDG-2d),34,High,1
Q8WTT2,Nucleolar complex protein 3 homolog OS=Homo sapiens OX=9606 GN=NOC3L PE=1 SV=1,0.003,6.02,4,3,50,3,800,92.5,9.17,16567,,3,,cell differentiation,mitochondrion;nucleus,RNA binding,"Pf03914, Pf07540",64318,ENSG00000173145.11,NOC3L,10,,,,0,High,1
Q13201,Multimerin-1 OS=Homo sapiens OX=9606 GN=MMRN1 PE=1 SV=3,0.003,6.019,1,2,6,2,1228,138,7.93,2619,,2,,cell organization and biogenesis;coagulation;transport,cytoskeleton;extracellular;organelle lumen,metal ion binding;protein binding,"Pf00008, Pf00386, Pf06160, Pf07546, Pf07974, Pf12947",22915,ENSG00000138722.9,MMRN1,4,,,Platelet degranulation,4,High,1
Q96D53,"Atypical kinase COQ8B, mitochondrial OS=Homo sapiens OX=9606 GN=COQ8B PE=1 SV=2",0.003,6.018,2,1,4,1,544,60,7.23,2219,,1,,metabolic process,cytoplasm;cytosol;membrane;mitochondrion,catalytic activity;nucleotide binding,Pf03109,79934,ENSG00000123815.11,ADCK4; COQ8B,19,,,,0,High,1
O75843,AP-1 complex subunit gamma-like 2 OS=Homo sapiens OX=9606 GN=AP1G2 PE=1 SV=1,0.003,6.013,2,2,3,2,785,87.1,6.55,956,,2,,transport,endosome;Golgi;membrane,protein binding;transporter activity,"Pf01602, Pf02883",8906,ENSG00000213983.11,AP1G2,14,Lysosome,,Lysosome Vesicle Biogenesis,6,High,1
Q9HDC5,Junctophilin-1 OS=Homo sapiens OX=9606 GN=JPH1 PE=1 SV=2,0.003,6.011,4,2,6,2,661,71.6,9.32,1870,,2,,cellular homeostasis;regulation of biological process;transport,endoplasmic reticulum;membrane,structural molecule activity,Pf02493,56704,ENSG00000104369.4,JPH1,8,,,,0,High,1
O00139,Kinesin-like protein KIF2A OS=Homo sapiens OX=9606 GN=KIF2A PE=1 SV=3,0.003,5.999,2,2,7,2,706,79.9,6.68,3173,,2,,cell differentiation;cell division;cell organization and biogenesis;cellular component movement;development;transport,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,catalytic activity;motor activity;nucleotide binding;protein binding,Pf00225,3796,ENSG00000068796.16,KIF2A,5,,,COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; MHC class II antigen presentation,27,High,1
Q8IWP9,Coiled-coil domain-containing protein 28A OS=Homo sapiens OX=9606 GN=CCDC28A PE=1 SV=1,0.003,5.993,5,1,4,1,274,30.3,9.25,1830,,1,,,,protein binding,Pf13270,25901,ENSG00000024862.17,CCDC28A,6,,,,0,High,1
Q02094,Ammonium transporter Rh type A OS=Homo sapiens OX=9606 GN=RHAG PE=1 SV=2,0.003,5.992,2,1,10,1,409,44.2,6.84,4576,,1,,cellular homeostasis;transport,membrane,protein binding;transporter activity,Pf00909,6005,ENSG00000112077.15,RHAG,6,,,Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN); Rhesus glycoproteins mediate ammonium transport.; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide,11,High,1
Q8N5C6,S1 RNA-binding domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SRBD1 PE=1 SV=2,0.003,5.991,2,1,2,1,995,111.7,8.72,987,,1,,metabolic process,,RNA binding,"Pf00575, Pf09371, Pf12836, Pf14635, Pf14639",55133,ENSG00000068784.12,SRBD1,2,,,,0,High,1
Q16832,Discoidin domain-containing receptor 2 OS=Homo sapiens OX=9606 GN=DDR2 PE=1 SV=2,0.003,5.989,2,2,4,2,855,96.7,5.36,1192,,2,,cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus,cytoskeleton;membrane,catalytic activity;nucleotide binding;protein binding;receptor activity;signal transducer activity,"Pf00069, Pf00754, Pf07714",4921,ENSG00000162733.16,DDR2,1,,Endochondral Ossification,Non-integrin membrane-ECM interactions,3,High,1
Q9NXW9,Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 OS=Homo sapiens OX=9606 GN=ALKBH4 PE=1 SV=1,0.003,5.988,9,2,5,2,302,33.8,6.67,1621,,2,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;nucleus,catalytic activity;metal ion binding;protein binding,,54784,ENSG00000160993.3,ALKBH4,7,,,,0,High,1
Q96S06,Lipase maturation factor 1 OS=Homo sapiens OX=9606 GN=LMF1 PE=1 SV=1,0.003,5.983,4,1,7,1,567,64.8,9.31,1960,,1,,metabolic process;regulation of biological process;transport,endoplasmic reticulum;Golgi;membrane,,Pf06762,64788,ENSG00000103227.18,LMF1,16,,,Assembly of active LPL and LIPC lipase complexes,4,High,1
Q9BXT8-1,Isoform 2 of RING finger protein 17 OS=Homo sapiens OX=9606 GN=RNF17,0.003,5.983,1,1,4,1,653,73.7,6.16,2222,,1,,development,cytoplasm;nucleus,metal ion binding;protein binding,"Pf00567, Pf14634",56163,ENSG00000132972.18,RNF17,13,,,,0,High,1
Q02161,Blood group Rh(D) polypeptide OS=Homo sapiens OX=9606 GN=RHD PE=1 SV=3,0.003,5.982,2,1,6,1,417,45.2,8.5,2983,,1,,transport,membrane,transporter activity,Pf00909,6007,ENSG00000187010.19,RHD,1,,,,0,High,1
Q8NB37,Glutamine amidotransferase-like class 1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=GATD1 PE=1 SV=1,0.003,5.974,5,1,8,1,220,23.3,6.61,4099,,1,,,extracellular,,Pf01965,347862,ENSG00000177225.16,PDDC1; GATD1,11,,,,0,High,1
Q9P2E5,Chondroitin sulfate glucuronyltransferase OS=Homo sapiens OX=9606 GN=CHPF2 PE=2 SV=2,0.003,5.968,2,2,2,2,772,85.9,7.83,756,,2,,metabolic process,Golgi;membrane,catalytic activity,"Pf02434, Pf05679",54480,ENSG00000033100.16,CHPF2,7,Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate; Metabolic pathways,,Chondroitin sulfate biosynthesis,7,High,1
P56557,Transmembrane protein 50B OS=Homo sapiens OX=9606 GN=TMEM50B PE=1 SV=2,0.003,5.967,5,1,2,1,158,17.9,5.39,1240,,1,,,endoplasmic reticulum;membrane,,Pf05255,757,ENSG00000263160.6; ENSG00000142188.16,TMEM50B,21; CHR_HSCHR21_4_CTG1_1,,,,0,High,1
O95149,Snurportin-1 OS=Homo sapiens OX=9606 GN=SNUPN PE=1 SV=1,0.003,5.967,6,2,3,2,360,41.1,6.64,1273,,2,,cell organization and biogenesis;transport,cytoplasm;cytosol;nucleus,protein binding;RNA binding;transporter activity,Pf11538,10073,ENSG00000169371.13,SNUPN,15,RNA transport,,snRNP Assembly,4,High,1
P52824,Diacylglycerol kinase theta OS=Homo sapiens OX=9606 GN=DGKQ PE=1 SV=2,0.003,5.966,2,2,7,1,942,101.1,7.49,2231,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;endosome;membrane;nucleus,catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding,"Pf00130, Pf00609, Pf00781, Pf00788",1609,ENSG00000145214.13,DGKQ,4,Metabolic pathways; Phosphatidylinositol signaling system; Glycerophospholipid metabolism; Glycerolipid metabolism; Choline metabolism in cancer; Phospholipase D signaling pathway,,Effects of PIP2 hydrolysis; Gastrin-CREB signalling pathway via PKC and MAPK,14,High,1
Q8TCU4,Alstrom syndrome protein 1 OS=Homo sapiens OX=9606 GN=ALMS1 PE=1 SV=4,0.003,5.965,0,1,47,1,4168,460.8,6.28,23365,,1,,,,,,,,,,,,,0,High,1
O14641,Segment polarity protein dishevelled homolog DVL-2 OS=Homo sapiens OX=9606 GN=DVL2 PE=1 SV=1,0.003,5.961,4,2,9,2,736,78.9,6.02,2915,,2,,cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,protein binding,"Pf00595, Pf00610, Pf00778, Pf02377, Pf12316",1856,ENSG00000004975.11,DVL2,17,Signaling pathways regulating pluripotency of stem cells; Wnt signaling pathway; Hippo signaling pathway; Notch signaling pathway; HTLV-I infection; Breast cancer; Basal cell carcinoma; mTOR signaling pathway; Melanogenesis; Pathways in cancer,Neural Crest Differentiation; Notch Signaling Pathway; Wnt Signaling Pathway Netpath; Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds; ESC Pluripotency Pathways; Wnt Signaling in Kidney Disease; Wnt Signaling Pathway and Pluripotency; Wnt Signaling Pathway; DNA Damage Response (only ATM dependent),WNT mediated activation of DVL; Cargo recognition for clathrin-mediated endocytosis; Signaling by Hippo; Degradation of DVL; Negative regulation of TCF-dependent signaling by DVL-interacting proteins; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RHO GTPases Activate Formins; Asymmetric localization of PCP proteins; WNT5A-dependent internalization of FZD4,38,High,1
O95807,Transmembrane protein 50A OS=Homo sapiens OX=9606 GN=TMEM50A PE=1 SV=1,0.003,5.954,5,1,4,1,157,17.4,5.87,2598,,1,,,cytoplasm;endoplasmic reticulum;membrane,,Pf05255,23585,ENSG00000183726.10,TMEM50A,1,,,,0,High,1
Q6ZVX7,F-box only protein 50 OS=Homo sapiens OX=9606 GN=NCCRP1 PE=1 SV=1,0.003,5.95,3,1,10,1,275,30.8,6.62,4207,,1,,regulation of biological process,cytoplasm,,Pf04300,342897,ENSG00000188505.4,NCCRP1,19,,,,0,High,1
Q08117,TLE family member 5 OS=Homo sapiens OX=9606 GN=TLE5 PE=1 SV=4,0.003,5.946,6,1,2,1,197,22,6.37,1130,,1,,cell communication;development;metabolic process;regulation of biological process;response to stimulus,nucleus,protein binding,Pf03920,166,ENSG00000104964.14,AES,19,,Androgen receptor signaling pathway; Ectoderm Differentiation,Repression of WNT target genes,6,High,1
Q9H6F5,Coiled-coil domain-containing protein 86 OS=Homo sapiens OX=9606 GN=CCDC86 PE=1 SV=1,0.003,5.944,9,2,3,2,360,40.2,10.33,800,,2,,,nucleus,protein binding;RNA binding,,79080,ENSG00000110104.11,CCDC86,11,,,,0,High,1
P13224,Platelet glycoprotein Ib beta chain OS=Homo sapiens OX=9606 GN=GP1BB PE=1 SV=1,0.003,5.937,5,2,3,2,206,21.7,9.31,1345,,2,,coagulation;metabolic process;regulation of biological process;response to stimulus,membrane,protein binding;receptor activity;signal transducer activity,,2812; 100526833,ENSG00000203618.5,GP1BB; SEPT5-GP1BB,22,Hematopoietic cell lineage; Platelet activation; ECM-receptor interaction,,Platelet Aggregation (Plug Formation); Intrinsic Pathway of Fibrin Clot Formation; Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling,10,High,1
O15194,CTD small phosphatase-like protein OS=Homo sapiens OX=9606 GN=CTDSPL PE=1 SV=2,0.003,5.936,8,2,3,1,276,31.1,5.54,850,,2,,metabolic process;regulation of biological process,nucleus,catalytic activity;metal ion binding;protein binding,Pf03031,10217,ENSG00000144677.14,CTDSPL,3,,,,0,High,1
Q02156,Protein kinase C epsilon type OS=Homo sapiens OX=9606 GN=PRKCE PE=1 SV=1,0.003,5.936,1,1,1,1,737,83.6,7.12,595,,1,,cell death;cell division;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;Golgi;membrane;mitochondrion;nucleus,catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf00130, Pf00168, Pf00433, Pf07714",5581,ENSG00000171132.13,PRKCE,2,Aldosterone synthesis and secretion; cGMP-PKG signaling pathway; Tight junction; Inflammatory mediator regulation of TRP channels; AGE-RAGE signaling pathway in diabetic complications; MicroRNAs in cancer; Insulin resistance; Sphingolipid signaling pathway; Type II diabetes mellitus; Vascular smooth muscle contraction; Fc gamma R-mediated phagocytosis,Physiological and Pathological Hypertrophy  of the Heart; miRs in Muscle Cell Differentiation; Oncostatin M Signaling Pathway; Myometrial Relaxation and Contraction Pathways; G Protein Signaling Pathways; VEGFA-VEGFR2 Signaling Pathway; Wnt Signaling Pathway and Pluripotency; Wnt Signaling Pathway; Calcium Regulation in the Cardiac Cell,G alpha (z) signalling events; Effects of PIP2 hydrolysis; SHC1 events in ERBB2 signaling; Gastrin-CREB signalling pathway via PKC and MAPK; DAG and IP3 signaling; Role of phospholipids in phagocytosis,38,High,1
Q0PNE2,Elongator complex protein 6 OS=Homo sapiens OX=9606 GN=ELP6 PE=1 SV=1,0.003,5.931,3,1,5,1,266,29.8,6.84,2833,,1,,metabolic process;regulation of biological process,,,Pf09807,54859,ENSG00000163832.15,ELP6,3,,,HATs acetylate histones,3,High,1
Q9NQT5,Exosome complex component RRP40 OS=Homo sapiens OX=9606 GN=EXOSC3 PE=1 SV=3,0.003,5.928,5,1,4,1,275,29.6,8.1,1428,,1,,metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;protein binding;RNA binding,,51010,ENSG00000107371.12,EXOSC3,9,RNA degradation,,"Major pathway of rRNA processing in the nucleolus and cytosol; mRNA decay by 3' to 5' exoribonuclease; ATF4 activates genes; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; KSRP (KHSRP) binds and destabilizes mRNA",15,High,1
Q8NI99,Angiopoietin-related protein 6 OS=Homo sapiens OX=9606 GN=ANGPTL6 PE=1 SV=1,0.003,5.921,8,2,6,1,470,51.7,8.53,1070,,2,,cell differentiation;development,extracellular,,Pf00147,83854,ENSG00000130812.10,ANGPTL6,19,,,,0,High,1
Q9UBS0,Ribosomal protein S6 kinase beta-2 OS=Homo sapiens OX=9606 GN=RPS6KB2 PE=1 SV=2,0.003,5.918,4,2,4,2,482,53.4,7.34,1272,,2,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,catalytic activity;nucleotide binding,"Pf00069, Pf00433, Pf07714",6199,ENSG00000175634.14,RPS6KB2,11,AMPK signaling pathway; ErbB signaling pathway; TGF-beta signaling pathway; Endocrine resistance; Proteoglycans in cancer; Acute myeloid leukemia; Longevity regulating pathway; mTOR signaling pathway; Insulin signaling pathway; Choline metabolism in cancer; Longevity regulating pathway - multiple species; PI3K-Akt signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin resistance; Breast cancer; Fc gamma R-mediated phagocytosis; HIF-1 signaling pathway,IL-5 Signaling Pathway; AMP-activated Protein Kinase (AMPK) Signaling; Follicle Stimulating Hormone (FSH) signaling pathway; Angiopoietin Like Protein 8 Regulatory Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Cytoplasmic Ribosomal Proteins; Insulin Signaling; IL-2 Signaling Pathway,AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer,33,High,1
Q9UQ49,Sialidase-3 OS=Homo sapiens OX=9606 GN=NEU3 PE=1 SV=1,0.003,5.913,8,2,6,2,428,48.2,7.17,1605,,2,,metabolic process,cytoplasm;membrane,catalytic activity,Pf13088,10825,,NEU3,11,Other glycan degradation; Sphingolipid metabolism,,Glycosphingolipid metabolism; Sialic acid metabolism,12,High,1
P78537,Biogenesis of lysosome-related organelles complex 1 subunit 1 OS=Homo sapiens OX=9606 GN=BLOC1S1 PE=1 SV=2,0.003,5.913,11,1,1,1,153,17.3,9.33,558,,1,,cell organization and biogenesis;cellular component movement;metabolic process;transport,cytoplasm;cytosol;membrane;mitochondrion;organelle lumen;vacuole,protein binding,Pf06320,2647,ENSG00000135441.7,BLOC1S1,12,,,Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis,6,High,1
Q9UHN6,Cell surface hyaluronidase OS=Homo sapiens OX=9606 GN=CEMIP2 PE=1 SV=1,0.003,5.912,1,2,6,2,1383,154.3,8.15,1523,,2,,development;metabolic process,membrane,catalytic activity;metal ion binding;protein binding,Pf10162,23670,ENSG00000135048.13,TMEM2,9,,,,0,High,1
Q9BRS8,La-related protein 6 OS=Homo sapiens OX=9606 GN=LARP6 PE=1 SV=1,0.003,5.903,2,1,4,1,491,54.7,8.25,2262,,1,,metabolic process;regulation of biological process,cytoplasm;nucleus,protein binding;RNA binding,"Pf05383, Pf12901",55323,ENSG00000166173.10,LARP6,15,,,,0,High,1
P26045,Tyrosine-protein phosphatase non-receptor type 3 OS=Homo sapiens OX=9606 GN=PTPN3 PE=1 SV=2,0.003,5.897,2,2,5,2,913,103.9,7.03,1996,,2,,metabolic process;regulation of biological process,cytoplasm;cytoskeleton;membrane,catalytic activity;protein binding,"Pf00102, Pf00373, Pf00595, Pf00782, Pf09379, Pf09380, Pf13350, Pf14566",5774,ENSG00000070159.13,PTPN3,9,,,EGFR downregulation,4,High,1
Q9NWT8,Aurora kinase A-interacting protein OS=Homo sapiens OX=9606 GN=AURKAIP1 PE=1 SV=1,0.003,5.896,5,1,7,1,199,22.3,10.76,3834,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,membrane;mitochondrion;nucleus;ribosome,catalytic activity;protein binding,Pf08213,54998,ENSG00000175756.13,AURKAIP1,1,,,Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination,6,High,1
Q96F86,Enhancer of mRNA-decapping protein 3 OS=Homo sapiens OX=9606 GN=EDC3 PE=1 SV=1,0.003,5.889,8,2,4,2,508,56,7.11,1375,,2,,cell organization and biogenesis;metabolic process,cytoplasm;cytosol;membrane,catalytic activity;protein binding;RNA binding,"Pf03853, Pf09532, Pf12701",80153,ENSG00000179151.11,EDC3,15,RNA degradation,,mRNA decay by 5' to 3' exoribonuclease,4,High,1
Q13469,"Nuclear factor of activated T-cells, cytoplasmic 2 OS=Homo sapiens OX=9606 GN=NFATC2 PE=1 SV=2",0.003,5.886,5,2,29,2,925,100.1,7.28,10171,,2,,cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,DNA binding;protein binding,Pf00554,4773,ENSG00000101096.19,NFATC2,20,Wnt signaling pathway; VEGF signaling pathway; T cell receptor signaling pathway; Natural killer cell mediated cytotoxicity; cGMP-PKG signaling pathway; Axon guidance; Osteoclast differentiation; HTLV-I infection; Th1 and Th2 cell differentiation; Oxytocin signaling pathway; B cell receptor signaling pathway; Hepatitis B,Heart Development; B Cell Receptor Signaling Pathway; T-Cell Receptor and Co-stimulatory Signaling; Cardiac Hypertrophic Response; Initiation of transcription and translation elongation at the HIV-1 LTR; Wnt Signaling Pathway Netpath; T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 Signaling Pathway; T-Cell antigen Receptor (TCR)  Signaling Pathway,RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs); FCERI mediated Ca+2 mobilization; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT,37,High,1
P80217,Interferon-induced 35 kDa protein OS=Homo sapiens OX=9606 GN=IFI35 PE=1 SV=5,0.003,5.886,10,2,5,2,286,31.5,6.09,2010,,2,,regulation of biological process;response to stimulus,cytosol;nucleus,protein binding,"Pf07292, Pf07334",3430,ENSG00000068079.7,IFI35,17,,,Interferon alpha/beta signaling,4,High,1
Q9NWM3,CUE domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CUEDC1 PE=1 SV=1,0.003,5.876,6,2,4,2,386,42.2,5.68,983,,2,,,,protein binding,Pf02845,404093,ENSG00000180891.12,CUEDC1,17,,,,0,High,1
Q7L099,Protein RUFY3 OS=Homo sapiens OX=9606 GN=RUFY3 PE=1 SV=1,0.003,5.869,4,2,4,1,469,52.9,5.49,1318,,2,,cell differentiation;cell organization and biogenesis;development;regulation of biological process,cytoplasm;cytosol;membrane,protein binding,"Pf02463, Pf02759, Pf09726, Pf09731",22902,ENSG00000018189.12,RUFY3,4,,,,0,High,1
Q9NRY2,SOSS complex subunit C OS=Homo sapiens OX=9606 GN=INIP PE=1 SV=1,0.003,5.868,19,1,3,1,104,11.4,9.25,1544,,1,,metabolic process;response to stimulus,nucleus,protein binding,,58493,ENSG00000148153.13,INIP,9,,,,0,High,1
Q9UJX6,Anaphase-promoting complex subunit 2 OS=Homo sapiens OX=9606 GN=ANAPC2 PE=1 SV=1,0.003,5.867,3,2,3,2,822,93.8,5.22,1191,,2,,cell differentiation;cell division;metabolic process;regulation of biological process,cytosol;nucleus,catalytic activity;protein binding,"Pf00888, Pf08672",29882,ENSG00000176248.8,ANAPC2,9,Cell cycle; HTLV-I infection; Ubiquitin mediated proteolysis; Oocyte meiosis; Progesterone-mediated oocyte maturation,,APC/C:Cdc20 mediated degradation of Cyclin B; Inactivation of APC/C via direct inhibition of the APC/C complex; Autodegradation of Cdh1 by Cdh1:APC/C; APC-Cdc20 mediated degradation of Nek2A; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Antigen processing: Ubiquitination & Proteasome degradation; Phosphorylation of the APC/C; APC/C:Cdc20 mediated degradation of Securin; Separation of Sister Chromatids; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Senescence-Associated Secretory Phenotype (SASP),37,High,1
P06746,DNA polymerase beta OS=Homo sapiens OX=9606 GN=POLB PE=1 SV=3,0.003,5.861,3,1,3,1,335,38.2,8.95,1189,,1,,cell death;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,catalytic activity;DNA binding;metal ion binding;protein binding,"Pf10391, Pf14520, Pf14716, Pf14791, Pf14792",5423,ENSG00000070501.11,POLB,8,Base excision repair; HTLV-I infection; Viral carcinogenesis,Nucleotide Metabolism,APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Ub-specific processing proteases; Abasic sugar-phosphate removal via the single-nucleotide replacement pathway,17,High,1
Q9Y6U3,Adseverin OS=Homo sapiens OX=9606 GN=SCIN PE=1 SV=4,0.003,5.861,1,1,3,1,715,80.4,5.71,1436,,1,,cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytoskeleton,metal ion binding;protein binding,Pf00626,85477,ENSG00000006747.14,SCIN,7,Regulation of actin cytoskeleton; Fc gamma R-mediated phagocytosis; Viral carcinogenesis,Endochondral Ossification,,4,High,1
Q9NZN8,CCR4-NOT transcription complex subunit 2 OS=Homo sapiens OX=9606 GN=CNOT2 PE=1 SV=1,0.003,5.86,9,2,3,2,540,59.7,7.66,677,,2,,cell differentiation;development;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,catalytic activity;protein binding,Pf04153,4848,ENSG00000111596.11,CNOT2,12,RNA degradation,,TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Deadenylation of mRNA,10,High,1
P32121,Beta-arrestin-2 OS=Homo sapiens OX=9606 GN=ARRB2 PE=1 SV=2,0.003,5.86,6,2,16,1,409,46.1,7.69,5634,,2,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus,protein binding;structural molecule activity,"Pf00339, Pf02752",409,ENSG00000141480.17,ARRB2,17,Morphine addiction; Chemokine signaling pathway; MAPK signaling pathway; Dopaminergic synapse; Hedgehog signaling pathway; Olfactory transduction; Endocytosis,Corticotropin-releasing hormone signaling pathway; Myometrial Relaxation and Contraction Pathways; Wnt Signaling Pathway Netpath; MAPK Signaling Pathway; VEGFA-VEGFR2 Signaling Pathway; Chemokine signaling pathway; Calcium Regulation in the Cardiac Cell,Activated NOTCH1 Transmits Signal to the Nucleus; Cargo recognition for clathrin-mediated endocytosis; G alpha (s) signalling events; Signaling by BRAF and RAF fusions; Ub-specific processing proteases; MAP2K and MAPK activation; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Signaling by moderate kinase activity BRAF mutants; Thrombin signalling through proteinase activated receptors (PARs); Paradoxical activation of RAF signaling by kinase inactive BRAF; Activation of SMO; Interleukin-20 family signaling; WNT5A-dependent internalization of FZD4,55,High,1
Q7RTV0,PHD finger-like domain-containing protein 5A OS=Homo sapiens OX=9606 GN=PHF5A PE=1 SV=1,0.003,5.858,14,2,4,2,110,12.4,8.41,1746,,2,,metabolic process;regulation of biological process,nucleus;spliceosomal complex,DNA binding;metal ion binding;RNA binding,Pf03660,84844,ENSG00000100410.7,PHF5A,22,Spliceosome,mRNA Processing,mRNA Splicing - Major Pathway,6,High,1
Q7L1T6,Cytochrome b5 reductase 4 OS=Homo sapiens OX=9606 GN=CYB5R4 PE=1 SV=1,0.003,5.854,5,2,3,2,521,59.4,7.72,1086,,2,,metabolic process;response to stimulus;transport,endoplasmic reticulum;membrane,catalytic activity;metal ion binding,"Pf00173, Pf00175, Pf00970, Pf04969",51167,ENSG00000065615.13,CYB5R4,6,Amino sugar and nucleotide sugar metabolism,Oxidation by Cytochrome P450,Erythrocytes take up carbon dioxide and release oxygen,5,High,1
P20036,"HLA class II histocompatibility antigen, DP alpha 1 chain OS=Homo sapiens OX=9606 GN=HLA-DPA1 PE=1 SV=1",0.003,5.843,5,1,3,1,260,29.4,5.21,1213,,1,,regulation of biological process;response to stimulus,cell surface;endoplasmic reticulum;endosome;Golgi;membrane;vacuole,receptor activity;signal transducer activity,"Pf00993, Pf07654",3113,ENSG00000231389.7; ENSG00000235844.8; ENSG00000229685.8; ENSG00000224103.7; ENSG00000236177.9; ENSG00000168384.11; ENSG00000206291.10; ENSG00000228163.8,HLA-DPA1,6; CHR_HSCHR6_MHC_APD_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_QBL_CTG1; CHR_HSCHR6_MHC_MANN_CTG1,Cell adhesion molecules (CAMs); Graft-versus-host disease; Epstein-Barr virus infection; Herpes simplex infection; Asthma; Phagosome; Tuberculosis; Intestinal immune network for IgA production; Leishmaniasis; Staphylococcus aureus infection; Hematopoietic cell lineage; Systemic lupus erythematosus; Th1 and Th2 cell differentiation; Toxoplasmosis; Rheumatoid arthritis; Influenza A; Viral myocarditis; Autoimmune thyroid disease; HTLV-I infection; Type I diabetes mellitus; Allograft rejection; Inflammatory bowel disease (IBD); Antigen processing and presentation,Allograft Rejection,PD-1 signaling; Translocation of ZAP-70 to Immunological synapse; MHC class II antigen presentation; Downstream TCR signaling; Generation of second messenger molecules; Interferon gamma signaling; Phosphorylation of CD3 and TCR zeta chains,37,High,1
O95427,GPI ethanolamine phosphate transferase 1 OS=Homo sapiens OX=9606 GN=PIGN PE=1 SV=1,0.003,5.843,2,1,1,1,931,105.7,8.65,482,,1,,metabolic process,cytosol;endoplasmic reticulum;membrane,catalytic activity,"Pf00884, Pf01663, Pf04987",23556,ENSG00000197563.10,PIGN,18,Metabolic pathways; Glycosylphosphatidylinositol (GPI)-anchor biosynthesis,,Synthesis of glycosylphosphatidylinositol (GPI),6,High,1
P41743,Protein kinase C iota type OS=Homo sapiens OX=9606 GN=PRKCI PE=1 SV=2,0.003,5.824,2,1,3,1,596,68.2,5.85,1181,,1,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endosome;membrane;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf00130, Pf00433, Pf00564, Pf07714, Pf14531",5584,ENSG00000163558.12,PRKCI,3,Rap1 signaling pathway; Insulin signaling pathway; Endocytosis; Platelet activation; Hippo signaling pathway; Tight junction,miRs in Muscle Cell Differentiation; Signaling Pathways in Glioblastoma; Corticotropin-releasing hormone signaling pathway; G Protein Signaling Pathways; VEGFA-VEGFR2 Signaling Pathway; Wnt Signaling Pathway and Pluripotency; Wnt Signaling Pathway; EGF/EGFR Signaling Pathway; Insulin Signaling,Tight junction interactions; Signalling by NGF; p75NTR recruits signalling complexes,25,High,1
Q9UJY4,ADP-ribosylation factor-binding protein GGA2 OS=Homo sapiens OX=9606 GN=GGA2 PE=1 SV=3,0.003,5.815,5,1,5,1,613,67.1,6.55,1633,,1,,metabolic process;transport,endosome;Golgi;membrane,protein binding,"Pf00790, Pf02883, Pf03127",23062,ENSG00000103365.15,GGA2,16,Lysosome,,TBC/RABGAPs; Amyloid fiber formation,7,High,1
Q9NRS6,Sorting nexin-15 OS=Homo sapiens OX=9606 GN=SNX15 PE=1 SV=1,0.003,5.804,7,2,6,2,342,38.3,5.19,1626,,2,,regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane,protein binding,"Pf00787, Pf04212",29907,ENSG00000110025.12,SNX15,11,,,,0,High,1
E9PRG8,Uncharacterized protein C11orf98 OS=Homo sapiens OX=9606 GN=C11orf98 PE=4 SV=2,0.003,5.801,11,1,3,1,123,14.2,11.53,1419,,1,,,,,,,,,,,,,0,High,1
Q9H814,Phosphorylated adapter RNA export protein OS=Homo sapiens OX=9606 GN=PHAX PE=1 SV=1,0.003,5.798,3,1,4,1,394,44.4,5.4,1641,,1,,metabolic process;transport,cytoplasm;cytosol;nucleus,protein binding;RNA binding,Pf10258,51808,ENSG00000164902.13,PHAX,5,RNA transport,,snRNP Assembly; RNA polymerase II transcribes snRNA genes,7,High,1
Q9H496,"Torsin-1A-interacting protein 2, isoform IFRG15 OS=Homo sapiens OX=9606 GN=TOR1AIP2 PE=1 SV=1",0.003,5.796,11,1,4,1,131,15.3,7.31,1872,,1,,cell organization and biogenesis;regulation of biological process,endoplasmic reticulum;membrane,enzyme regulator activity;protein binding,,163590,ENSG00000169905.12,TOR1AIP2,1,,,,0,High,1
O43286,"Beta-1,4-galactosyltransferase 5 OS=Homo sapiens OX=9606 GN=B4GALT5 PE=1 SV=1",0.003,5.794,2,1,5,1,388,45.1,8.15,3296,,1,,metabolic process,Golgi;membrane,catalytic activity;metal ion binding,"Pf02709, Pf10111, Pf13733",9334,ENSG00000158470.5,B4GALT5,20,Mucin type O-glycan biosynthesis,,Keratan sulfate biosynthesis; N-Glycan antennae elongation; O-linked glycosylation of mucins,14,High,1
Q9Y6D0,Selenoprotein K OS=Homo sapiens OX=9606 GN=SELENOK PE=1 SV=3,0.003,5.794,14,1,8,1,94,10.6,10.86,4050,,1,,cell differentiation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;Golgi;membrane,protein binding,Pf10961,58515,ENSG00000113811.10,SELK; SELENOK,3,,Selenium Micronutrient Network; Selenium Metabolism and Selenoproteins,,2,High,1
Q96EI5,Transcription elongation factor A protein-like 4 OS=Homo sapiens OX=9606 GN=TCEAL4 PE=1 SV=2,0.003,5.791,14,2,5,2,215,24.6,5.2,1468,,2,,metabolic process;regulation of biological process,nucleus,protein binding,Pf04538,79921,ENSG00000133142.17,TCEAL4,X,,,,0,High,1
P54760,Ephrin type-B receptor 4 OS=Homo sapiens OX=9606 GN=EPHB4 PE=1 SV=2,0.003,5.787,1,1,2,1,987,108.2,6.9,1368,,1,,cellular component movement;development;metabolic process;regulation of biological process;response to stimulus,cytosol;extracellular;membrane,catalytic activity;nucleotide binding;protein binding;receptor activity;signal transducer activity,"Pf00041, Pf00069, Pf00536, Pf01404, Pf07647, Pf07699, Pf07714, Pf14575",2050,ENSG00000196411.9,EPHB4,7,Axon guidance,,EPH-ephrin mediated repulsion of cells; Ephrin signaling; EPHB-mediated forward signaling,7,High,1
Q96G28,Cilia- and flagella-associated protein 36 OS=Homo sapiens OX=9606 GN=CFAP36 PE=1 SV=2,0.003,5.764,12,2,3,2,342,39.4,4.97,781,,2,,,cytoplasm;nucleus,protein binding,Pf11527,112942,ENSG00000163001.11,CCDC104; CFAP36,2,,,,0,High,1
Q9NRP2,COX assembly mitochondrial protein 2 homolog OS=Homo sapiens OX=9606 GN=CMC2 PE=1 SV=1,0.003,5.763,13,1,27,1,79,9.5,7.87,12268,,1,,,mitochondrion,,Pf08583,56942,ENSG00000103121.8,CMC2,16,,,Mitochondrial protein import; Metabolism of proteins,2,High,1
Q96EY4,Translation machinery-associated protein 16 OS=Homo sapiens OX=9606 GN=TMA16 PE=1 SV=2,0.003,5.756,6,1,1,1,203,23.8,9.26,508,,1,,,nucleus;ribosome,protein binding,Pf11176,55319,ENSG00000198498.9,TMA16,4,,,,0,High,1
Q3ZAQ7,Vacuolar ATPase assembly integral membrane protein VMA21 OS=Homo sapiens OX=9606 GN=VMA21 PE=1 SV=1,0.003,5.742,25,2,6,2,101,11.3,7.24,1574,,2,,cell organization and biogenesis;regulation of biological process,endoplasmic reticulum;membrane;vacuole,,Pf09446,203547,ENSG00000160131.13,VMA21,X,,,,0,High,1
Q969E8,Pre-rRNA-processing protein TSR2 homolog OS=Homo sapiens OX=9606 GN=TSR2 PE=1 SV=1,0.003,5.738,6,1,4,1,191,20.9,4.39,1930,,1,,metabolic process,nucleus,protein binding,Pf10273,90121,ENSG00000158526.7,TSR2,X,,,,0,High,1
Q6ZUX3,TOG array regulator of axonemal microtubules protein 2 OS=Homo sapiens OX=9606 GN=TOGARAM2 PE=2 SV=2,0.003,5.727,2,1,2,1,1019,111.1,9.42,,3.08,,1,,,,Pf12348,165186,ENSG00000189350.12,FAM179A; TOGARAM2,2,,,,0,High,1
Q6KC79,Nipped-B-like protein OS=Homo sapiens OX=9606 GN=NIPBL PE=1 SV=2,0.003,5.727,0,1,2,1,2804,315.9,7.91,1299,,1,,cell differentiation;cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus,chromosome;nucleus,DNA binding;protein binding,"Pf03154, Pf03344, Pf05110, Pf05793, Pf07420, Pf10243, Pf11489, Pf12765, Pf12830",25836,ENSG00000164190.17,NIPBL,5,,,Cohesin Loading onto Chromatin,5,High,1
Q9BX59,Tapasin-related protein OS=Homo sapiens OX=9606 GN=TAPBPL PE=1 SV=2,0.003,5.726,4,1,2,1,468,50.2,5.26,1077,,1,,regulation of biological process,endoplasmic reticulum;Golgi;membrane,protein binding,"Pf07654, Pf08205",55080,ENSG00000139192.11,TAPBPL,12,,,,0,High,1
Q53F19,Nuclear cap-binding protein subunit 3 OS=Homo sapiens OX=9606 GN=NCBP3 PE=1 SV=2,0.003,5.725,4,2,2,2,620,70.5,5.73,616,,2,,defense response;metabolic process;response to stimulus;transport,cytoplasm;nucleus,catalytic activity;metal ion binding;protein binding;RNA binding,"Pf08675, Pf10309",55421,ENSG00000074356.16,C17orf85; NCBP3,17,,,,0,High,1
Q9H8M5,Metal transporter CNNM2 OS=Homo sapiens OX=9606 GN=CNNM2 PE=1 SV=2,0.003,5.722,3,2,2,1,875,96.6,6.38,579,,2,,transport,membrane,nucleotide binding;transporter activity,"Pf00571, Pf01595",54805,ENSG00000148842.17,CNNM2,10,,,,0,High,1
P68543,UBX domain-containing protein 2A OS=Homo sapiens OX=9606 GN=UBXN2A PE=1 SV=1,0.003,5.711,5,1,4,1,259,29.3,6.25,1450,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,cytosol;endoplasmic reticulum;nucleus,enzyme regulator activity;protein binding,"Pf00789, Pf08059",165324,ENSG00000173960.13,UBXN2A,2,,,,0,High,1
Q14392,Transforming growth factor beta activator LRRC32 OS=Homo sapiens OX=9606 GN=LRRC32 PE=1 SV=1,0.003,5.707,3,2,16,2,662,71.9,6.13,5222,,2,,regulation of biological process,membrane,protein binding,"Pf01462, Pf12799, Pf13855",2615,ENSG00000137507.11,LRRC32,11,,,,0,High,1
Q9GZZ8,Extracellular glycoprotein lacritin OS=Homo sapiens OX=9606 GN=LACRT PE=1 SV=1,0.003,5.688,9,1,4,1,138,14.2,5.5,1817,,1,,defense response;metabolic process;regulation of biological process;response to stimulus;transport,extracellular,protein binding,,90070,ENSG00000135413.8,LACRT,12,,,,0,High,1
Q8IUI8,Cytokine receptor-like factor 3 OS=Homo sapiens OX=9606 GN=CRLF3 PE=1 SV=2,0.003,5.683,4,2,4,2,442,49.7,5.14,1099,,2,,regulation of biological process,cytoplasm;cytosol;membrane,protein binding,Pf00041,51379,ENSG00000176390.11,CRLF3,17,,,,0,High,1
Q969J3,BLOC-1-related complex subunit 5 OS=Homo sapiens OX=9606 GN=BORCS5 PE=1 SV=1,0.003,5.677,11,2,5,2,196,22.2,6.35,1864,,2,,cellular component movement;transport,membrane;vacuole,protein binding,Pf10158,118426,ENSG00000280689.2; ENSG00000165714.10,LOH12CR1; BORCS5,12; CHR_HG1362_PATCH,,,,0,High,1
O15440,Multidrug resistance-associated protein 5 OS=Homo sapiens OX=9606 GN=ABCC5 PE=1 SV=2,0.003,5.675,2,2,4,2,1437,160.6,8.66,1452,,2,,metabolic process;transport,membrane,catalytic activity;nucleotide binding;transporter activity,"Pf00005, Pf00664, Pf13304",10057,ENSG00000114770.16,ABCC5,3,ABC transporters; Antifolate resistance,Fluoropyrimidine Activity; NRF2 pathway,Hyaluronan biosynthesis and export; ABC-family proteins mediated transport,11,High,1
O95081,Arf-GAP domain and FG repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=AGFG2 PE=1 SV=2,0.003,5.673,2,1,7,1,481,48.9,9.11,3778,,1,,regulation of biological process,membrane,enzyme regulator activity;metal ion binding,Pf01412,3268,ENSG00000106351.12,AGFG2,7,,,,0,High,1
Q9NUQ3,Gamma-taxilin OS=Homo sapiens OX=9606 GN=TXLNG PE=1 SV=2,0.003,5.673,5,2,13,2,528,60.5,7.52,4367,,2,,metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;nucleus,protein binding,Pf09728,55787,ENSG00000086712.12,TXLNG,X,,,,0,High,1
Q96HV5,Transmembrane protein 41A OS=Homo sapiens OX=9606 GN=TMEM41A PE=1 SV=1,0.003,5.673,6,1,7,1,264,29.6,9.03,2142,,1,,,membrane,protein binding,Pf09335,90407,ENSG00000163900.10,TMEM41A,3,,,,0,High,1
A8MTT3,Protein CEBPZOS OS=Homo sapiens OX=9606 GN=CEBPZOS PE=1 SV=2,0.003,5.672,14,1,5,1,80,9.3,9.7,2000,,1,,,membrane;mitochondrion,,,100505876,ENSG00000218739.9,LOC100505876; CEBPZ-AS1; CEBPZOS,2,,,,0,High,1
P36402,Transcription factor 7 OS=Homo sapiens OX=9606 GN=TCF7 PE=1 SV=3,0.003,5.671,3,1,36,1,384,41.6,6.81,20369,,1,,cell differentiation;metabolic process;regulation of biological process;response to stimulus,nucleus,DNA binding;protein binding,"Pf00505, Pf08347",6932,,TCF7,5,Pathways in cancer; Thyroid cancer; Acute myeloid leukemia; Prostate cancer; Basal cell carcinoma; Endometrial cancer; Melanogenesis; Breast cancer; Wnt signaling pathway; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Colorectal cancer; Adherens junction; Hippo signaling pathway,Arrhythmogenic Right Ventricular Cardiomyopathy; Endoderm Differentiation; Amplification and Expansion of Oncogenic Pathways as Metastatic Traits; Wnt Signaling Pathway and Pluripotency; DNA Damage Response (only ATM dependent),RUNX3 regulates WNT signaling; Binding of TCF/LEF:CTNNB1 to target gene promoters; Repression of WNT target genes; Deactivation of the beta-catenin transactivating complex; Ca2+ pathway,33,High,1
Q69YQ0,Cytospin-A OS=Homo sapiens OX=9606 GN=SPECC1L PE=1 SV=2,0.003,5.668,2,2,8,2,1117,124.5,5.72,3943,,2,,cell division;metabolic process,cytoplasm;cytoskeleton;cytosol,protein binding;structural molecule activity,"Pf00038, Pf00307, Pf01920, Pf02463, Pf03251, Pf04111, Pf04156, Pf05667, Pf05701, Pf08317, Pf11971, Pf12128, Pf13166",23384,,SPECC1L,22,,,,0,High,1
O95835,Serine/threonine-protein kinase LATS1 OS=Homo sapiens OX=9606 GN=LATS1 PE=1 SV=1,0.003,5.665,1,1,7,1,1130,126.8,8.7,2327,2.48,1,1,cell differentiation;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf00433, Pf00627, Pf01636, Pf07714, Pf14531",9113,ENSG00000131023.12,LATS1,6,Hippo signaling pathway; Hippo signaling pathway -multiple species,Mesodermal Commitment Pathway,Signaling by Hippo,5,High,1
Q9BXW9,Fanconi anemia group D2 protein OS=Homo sapiens OX=9606 GN=FANCD2 PE=1 SV=2,0.003,5.662,2,3,6,3,1451,164,5.88,2338,,3,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;cytosol;nucleus,protein binding,Pf14631,2177,ENSG00000144554.10,FANCD2,3,Fanconi anemia pathway,miRNA Regulation of DNA Damage Response; DNA Damage Response,Fanconi Anemia Pathway; TP53 Regulates Transcription of DNA Repair Genes,10,High,1
Q9H6R4,Nucleolar protein 6 OS=Homo sapiens OX=9606 GN=NOL6 PE=1 SV=2,0.003,5.658,1,1,2,1,1146,127.5,7.64,958,,1,,metabolic process;transport,chromosome;mitochondrion;nucleus,protein binding;RNA binding,Pf03813,65083,ENSG00000165271.16,NOL6,9,Ribosome biogenesis in eukaryotes,,Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol,6,High,1
Q9UK61,Protein TASOR OS=Homo sapiens OX=9606 GN=TASOR PE=1 SV=3,0.003,5.652,2,2,5,2,1670,188.9,5.8,1290,,2,,metabolic process;regulation of biological process,chromosome;nucleus,protein binding;RNA binding,Pf12509,23272,,FAM208A,3,,,,0,High,1
Q9BZG8,2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 OS=Homo sapiens OX=9606 GN=DPH1 PE=1 SV=2,0.003,5.645,2,1,3,1,443,48.8,8.18,1733,,1,,cell proliferation;metabolic process,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,Pf01866,1801,ENSG00000108963.17,DPH1,17,,,Synthesis of diphthamide-EEF2,4,High,1
Q9UBD5,Origin recognition complex subunit 3 OS=Homo sapiens OX=9606 GN=ORC3 PE=1 SV=1,0.003,5.641,2,1,5,1,711,82.2,7.61,1949,,1,,cell organization and biogenesis;cell proliferation;metabolic process,nucleus,DNA binding;protein binding,Pf07034,23595,ENSG00000135336.14,ORC3,6,Cell cycle,Cell Cycle; G1 to S cell cycle control; DNA Replication,M/G1 Transition; CDT1 association with the CDC6:ORC:origin complex; Regulation of DNA replication; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDC6 association with the ORC:origin complex; Association of licensing factors with the pre-replicative complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication; Orc1 removal from chromatin; Removal of licensing factors from origins,28,High,1
P62875,"DNA-directed RNA polymerases I, II, and III subunit RPABC5 OS=Homo sapiens OX=9606 GN=POLR2L PE=1 SV=1",0.003,5.641,16,1,2,1,67,7.6,7.77,1006,,1,,metabolic process;regulation of biological process;response to stimulus,cytosol;nucleus,catalytic activity;DNA binding;metal ion binding;protein binding,Pf01194,5441,ENSG00000177700.5,POLR2L,11,Pyrimidine metabolism; Purine metabolism; RNA polymerase; Epstein-Barr virus infection; Metabolic pathways; Cytosolic DNA-sensing pathway; Huntington's disease,,Signaling by FGFR2 IIIa TM; RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Tat-mediated HIV elongation arrest and recovery; NoRC negatively regulates rRNA expression; Formation of HIV-1 elongation complex containing HIV-1 Tat; MicroRNA (miRNA) biogenesis; RNA Polymerase III Transcription Termination; Formation of the HIV-1 Early Elongation Complex; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; TP53 Regulates Transcription of DNA Repair Genes; Transcriptional regulation by small RNAs; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; RNA Polymerase II HIV Promoter Escape; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase III Chain Elongation; Transcriptional regulation of pluripotent stem cells; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase I Chain Elongation; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; Formation of TC-NER Pre-Incision Complex; Pausing and recovery of HIV elongation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase I Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase III Abortive And Retractive Initiation; HIV elongation arrest and recovery; RNA Pol II CTD phosphorylation and interaction with CE; Viral Messenger RNA Synthesis; RNA Polymerase I Transcription Termination; RNA Polymerase II Transcription Initiation; mRNA Capping; Dual incision in TC-NER; PIWI-interacting RNA (piRNA) biogenesis; RNA Polymerase III Transcription Initiation From Type 1 Promoter; B-WICH complex positively regulates rRNA expression; Cytosolic sensors of pathogen-associated DNA ; Pausing and recovery of Tat-mediated HIV elongation; RNA Polymerase I Transcription Initiation; Formation of the Early Elongation Complex; RNA Polymerase III Transcription Initiation From Type 2 Promoter,97,High,1
Q8TEY7,Ubiquitin carboxyl-terminal hydrolase 33 OS=Homo sapiens OX=9606 GN=USP33 PE=1 SV=2,0.003,5.626,4,2,3,2,942,106.7,6.02,730,,2,,cell communication;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;Golgi;vacuole,catalytic activity;metal ion binding;protein binding,"Pf00443, Pf02148, Pf06337, Pf13423",23032,ENSG00000077254.14,USP33,1,,,Regulation of expression of SLITs and ROBOs; Ub-specific processing proteases,8,High,1
Q93070,Ecto-ADP-ribosyltransferase 4 OS=Homo sapiens OX=9606 GN=ART4 PE=2 SV=2,0.003,5.623,6,2,5,1,314,35.9,9.22,1436,,2,,metabolic process,extracellular;membrane,catalytic activity,Pf01129,420,,ART4,12,,,Post-translational modification: synthesis of GPI-anchored proteins,3,High,1
O15013,Rho guanine nucleotide exchange factor 10 OS=Homo sapiens OX=9606 GN=ARHGEF10 PE=1 SV=4,0.003,5.621,2,2,5,2,1369,151.5,5.68,1874,,2,,cell organization and biogenesis;regulation of biological process,cytosol,protein binding,Pf00621,9639,ENSG00000274726.4; ENSG00000104728.15,ARHGEF10,8; CHR_HSCHR8_8_CTG1,,,G alpha (12/13) signalling events; NRAGE signals death through JNK; Signalling by NGF; Rho GTPase cycle,11,High,1
Q15269,Periodic tryptophan protein 2 homolog OS=Homo sapiens OX=9606 GN=PWP2 PE=2 SV=2,0.003,5.618,1,1,10,1,919,102.4,6.15,4116,,1,,cell organization and biogenesis;metabolic process,nucleus,protein binding;RNA binding,"Pf00400, Pf04003",5822; 102724159,ENSG00000241945.7,PWP2; LOC102724159,21,Ribosome biogenesis in eukaryotes,,Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol,6,High,1
O95772,STARD3 N-terminal-like protein OS=Homo sapiens OX=9606 GN=STARD3NL PE=1 SV=1,0.003,5.614,6,1,8,1,234,26.6,4.81,2878,,1,,metabolic process,cytosol;endosome;membrane,protein binding,Pf10457,83930,ENSG00000010270.13,STARD3NL,7,,,Pregnenolone biosynthesis,5,High,1
Q9BSC4,Nucleolar protein 10 OS=Homo sapiens OX=9606 GN=NOL10 PE=1 SV=1,0.003,5.607,2,2,13,2,688,80.3,8.46,5927,,2,,,nucleus,protein binding;RNA binding,Pf08159,79954,ENSG00000115761.15,NOL10,2,,,,0,High,1
P58335,Anthrax toxin receptor 2 OS=Homo sapiens OX=9606 GN=ANTXR2 PE=1 SV=5,0.003,5.606,2,1,6,1,489,53.6,7.46,3080,,1,,transport,cell surface;endoplasmic reticulum;extracellular;membrane,metal ion binding;protein binding;receptor activity,"Pf00092, Pf05586, Pf05587, Pf13519",118429,ENSG00000163297.16,ANTXR2,4,NOD-like receptor signaling pathway,,Uptake and function of anthrax toxins,5,High,1
Q9P0M2,A-kinase anchor protein 7 isoform gamma OS=Homo sapiens OX=9606 GN=AKAP7 PE=1 SV=2,0.003,5.605,9,2,3,2,348,39.5,6.16,704,,2,,regulation of biological process,cytoplasm;cytosol;nucleus,nucleotide binding;protein binding,"Pf10469, Pf10470",9465,ENSG00000118507.15,AKAP7,6,,G Protein Signaling Pathways,,1,High,1
Q86UW9,Probable E3 ubiquitin-protein ligase DTX2 OS=Homo sapiens OX=9606 GN=DTX2 PE=1 SV=3,0.003,5.604,2,1,11,1,622,67.2,8.47,5558,,1,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;membrane;nucleus,catalytic activity;metal ion binding;protein binding,"Pf00097, Pf02825",113878,ENSG00000091073.19,DTX2,7,Notch signaling pathway,Notch Signaling Pathway,Activated NOTCH1 Transmits Signal to the Nucleus,6,High,1
Q9UQ03,Coronin-2B OS=Homo sapiens OX=9606 GN=CORO2B PE=1 SV=4,0.003,5.6,3,1,1,1,480,54.9,8.27,483,,1,,cell organization and biogenesis,cytoplasm;cytoskeleton;membrane,protein binding,"Pf00400, Pf04977, Pf08953, Pf08954",10391,ENSG00000103647.12,CORO2B,15,,,,0,High,1
Q6P3X3,Tetratricopeptide repeat protein 27 OS=Homo sapiens OX=9606 GN=TTC27 PE=1 SV=1,0.003,5.597,2,2,3,2,843,96.6,5.59,975,,2,,,,protein binding,"Pf00515, Pf07719, Pf13281, Pf13371, Pf13414, Pf13424, Pf13432",55622,ENSG00000018699.11,TTC27,2,,,,0,High,1
Q8IXQ5,Kelch-like protein 7 OS=Homo sapiens OX=9606 GN=KLHL7 PE=1 SV=2,0.003,5.596,4,2,2,2,586,65.9,6.48,594,,2,,metabolic process,cytoplasm;cytosol;membrane;nucleus,catalytic activity;protein binding,"Pf00651, Pf01344, Pf07646, Pf07707, Pf13415, Pf13418, Pf13964",55975,ENSG00000122550.17,KLHL7,7,,,,0,High,1
Q13094,Lymphocyte cytosolic protein 2 OS=Homo sapiens OX=9606 GN=LCP2 PE=1 SV=1,0.003,5.579,3,2,15,2,533,60.2,6.27,4062,,2,,regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane,protein binding,"Pf00017, Pf07647, Pf15449",3937,ENSG00000043462.11,LCP2,5,Rap1 signaling pathway; Platelet activation; T cell receptor signaling pathway; Natural killer cell mediated cytotoxicity; Osteoclast differentiation; Fc epsilon RI signaling pathway,T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection; T-Cell antigen Receptor (TCR)  Signaling Pathway,DAP12 signaling; FCERI mediated Ca+2 mobilization; Generation of second messenger molecules; GPVI-mediated activation cascade; FCERI mediated MAPK activation,21,High,1
Q8TDZ2,[F-actin]-monooxygenase MICAL1 OS=Homo sapiens OX=9606 GN=MICAL1 PE=1 SV=2,0.003,5.577,2,2,2,2,1067,117.8,6.4,594,,2,,cell organization and biogenesis;coagulation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00307, Pf00412, Pf00890, Pf01266, Pf01494, Pf07992, Pf11971, Pf12130, Pf13450",64780,ENSG00000135596.17,MICAL1,6,,,Factors involved in megakaryocyte development and platelet production,2,High,1
Q9NZD2,Glycolipid transfer protein OS=Homo sapiens OX=9606 GN=GLTP PE=1 SV=3,0.003,5.573,7,1,28,1,209,23.8,7.39,12881,,1,,metabolic process;transport,cytoplasm;cytosol;membrane,protein binding;transporter activity,Pf08718,51228,ENSG00000139433.9,GLTP,12,,,Glycosphingolipid metabolism,4,High,1
Q96PM5,RING finger and CHY zinc finger domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RCHY1 PE=1 SV=1,0.003,5.57,4,1,2,1,261,30.1,6.71,717,,1,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;protein binding,"Pf05495, Pf13639, Pf13923, Pf14599",25898,ENSG00000163743.13,RCHY1,4,Measles; Ubiquitin mediated proteolysis; p53 signaling pathway,,Antigen processing: Ubiquitination & Proteasome degradation; Translesion Synthesis by POLH,11,High,1
Q8NHP6,Motile sperm domain-containing protein 2 OS=Homo sapiens OX=9606 GN=MOSPD2 PE=1 SV=1,0.003,5.567,3,2,3,2,518,59.7,5.96,1196,,2,,regulation of biological process;response to stimulus;transport,membrane,,"Pf00635, Pf00650, Pf13716",158747,ENSG00000130150.11,MOSPD2,X,,,Neutrophil degranulation,3,High,1
P60606,Cortexin-1 OS=Homo sapiens OX=9606 GN=CTXN1 PE=3 SV=1,0.003,5.557,16,1,363,1,82,9,5.24,156858,,1,,,membrane,,Pf11057,404217,ENSG00000178531.5,CTXN1,19,,,,0,High,1
Q6NTF9,Rhomboid domain-containing protein 2 OS=Homo sapiens OX=9606 GN=RHBDD2 PE=2 SV=2,0.003,5.552,7,2,2,2,364,39.2,9.32,796,,2,,metabolic process,Golgi;membrane;nucleus,catalytic activity,"Pf01694, Pf03153",57414,ENSG00000005486.16,RHBDD2,7,,,,0,High,1
O00469,"Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 OS=Homo sapiens OX=9606 GN=PLOD2 PE=1 SV=2",0.003,5.541,2,1,1,1,737,84.6,6.71,614,,1,,metabolic process;response to stimulus,endoplasmic reticulum;membrane,catalytic activity;metal ion binding,Pf03171,5352,ENSG00000152952.11,PLOD2,3,Lysine degradation,,Collagen biosynthesis and modifying enzymes,4,High,1
O15078,Centrosomal protein of 290 kDa OS=Homo sapiens OX=9606 GN=CEP290 PE=1 SV=2,0.003,5.537,0,1,22,1,2479,290.2,5.95,11081,,1,,cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;extracellular;membrane;nucleus;organelle lumen,protein binding,,80184,ENSG00000198707.14,CEP290,12,,,Neutrophil degranulation; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes,19,High,1
Q5TGY3,AT-hook DNA-binding motif-containing protein 1 OS=Homo sapiens OX=9606 GN=AHDC1 PE=1 SV=1,0.003,5.533,2,2,2,2,1603,168.2,9.04,526,,2,,,,DNA binding,,27245,ENSG00000126705.13,AHDC1,1,,Mesodermal Commitment Pathway,,1,High,1
Q9HC62,Sentrin-specific protease 2 OS=Homo sapiens OX=9606 GN=SENP2 PE=1 SV=3,0.003,5.532,3,2,42,2,589,67.8,9.48,13694,,2,,cell differentiation;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus,catalytic activity;protein binding,Pf02902,59343,ENSG00000163904.12,SENP2,3,RNA transport; Wnt signaling pathway,,SUMO is proteolytically processed,7,High,1
Q8WYL5,Protein phosphatase Slingshot homolog 1 OS=Homo sapiens OX=9606 GN=SSH1 PE=1 SV=2,0.003,5.532,2,1,1,1,1049,115.4,6.25,563,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane,catalytic activity;DNA binding;protein binding,"Pf00782, Pf08766",54434,ENSG00000084112.14,SSH1,12,Axon guidance; Regulation of actin cytoskeleton,Regulation of Actin Cytoskeleton,,3,High,1
Q13946,"High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A OS=Homo sapiens OX=9606 GN=PDE7A PE=1 SV=2",0.003,5.523,2,1,3,1,482,55.5,7.5,,10.91,,1,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,catalytic activity;metal ion binding,Pf00233,5150,ENSG00000205268.10,PDE7A,8,Purine metabolism; Morphine addiction,Ectoderm Differentiation; G Protein Signaling Pathways,G alpha (s) signalling events,8,High,1
Q8IXV7,Kelch domain-containing protein 8B OS=Homo sapiens OX=9606 GN=KLHDC8B PE=2 SV=1,0.003,5.519,4,1,1,1,354,37.7,8.27,522,,1,,cell division;metabolic process,cytoplasm;cytosol,catalytic activity;protein binding,"Pf01344, Pf13415, Pf13418, Pf13964",200942,ENSG00000185909.14,KLHDC8B,3,,,,0,High,1
Q6P5R6,60S ribosomal protein L22-like 1 OS=Homo sapiens OX=9606 GN=RPL22L1 PE=1 SV=2,0.004,5.517,12,2,11,1,122,14.6,9.38,3808,,2,,metabolic process,ribosome,RNA binding;structural molecule activity,Pf01776,200916,ENSG00000163584.17,RPL22L1,3,Ribosome,,Peptide chain elongation; Eukaryotic Translation Termination; Viral mRNA Translation; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Selenocysteine synthesis; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; SRP-dependent cotranslational protein targeting to membrane,33,High,1
P33992,DNA replication licensing factor MCM5 OS=Homo sapiens OX=9606 GN=MCM5 PE=1 SV=5,0.004,5.511,2,1,4,1,734,82.2,8.37,1784,,1,,cell division;metabolic process,membrane;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding,"Pf00493, Pf07728, Pf14551",4174,ENSG00000100297.15,MCM5,22,Cell cycle; DNA replication,Cell Cycle; G1 to S cell cycle control; DNA Replication,M/G1 Transition; Assembly of the pre-replicative complex; Unwinding of DNA; Regulation of DNA replication; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Orc1 removal from chromatin; Removal of licensing factors from origins,25,High,1
Q9P2E3,NFX1-type zinc finger-containing protein 1 OS=Homo sapiens OX=9606 GN=ZNFX1 PE=2 SV=2,0.004,5.509,1,2,6,2,1918,220.1,7.3,1525,,2,,regulation of biological process,nucleus,catalytic activity;DNA binding;metal ion binding;nucleotide binding;RNA binding,"Pf04851, Pf11437, Pf13086, Pf13087, Pf13245, Pf13604, Pf15042",57169,ENSG00000124201.14,ZNFX1,20,,,,0,High,1
P53805,Calcipressin-1 OS=Homo sapiens OX=9606 GN=RCAN1 PE=1 SV=4,0.004,5.503,5,1,3,1,252,28.1,5.21,1310,,1,,regulation of biological process;response to stimulus,cytoplasm;nucleus,DNA binding;enzyme regulator activity;protein binding,Pf04847,1827,ENSG00000159200.17,RCAN1,21,Thyroid hormone signaling pathway; Oxytocin signaling pathway,MicroRNAs in cardiomyocyte hypertrophy; VEGFA-VEGFR2 Signaling Pathway,,4,High,1
O14817,Tetraspanin-4 OS=Homo sapiens OX=9606 GN=TSPAN4 PE=1 SV=1,0.004,5.493,11,1,2,1,238,26.1,6.47,191,2.43,1,1,cell organization and biogenesis;regulation of biological process;response to stimulus,membrane,protein binding,Pf00335,7106,ENSG00000214063.10,TSPAN4,11,,,,0,High,1
Q96HH9,GRAM domain-containing protein 2B OS=Homo sapiens OX=9606 GN=GRAMD2B PE=1 SV=1,0.004,5.489,4,1,4,1,432,47.8,7.9,1164,,1,,,,protein binding,Pf02893,65983,ENSG00000155324.9,GRAMD3; GRAMD2B,5,,,,0,High,1
Q9Y6K0,Choline/ethanolaminephosphotransferase 1 OS=Homo sapiens OX=9606 GN=CEPT1 PE=1 SV=1,0.004,5.489,3,1,14,1,416,46.5,8.21,6221,,1,,metabolic process,endoplasmic reticulum;membrane;nucleus,catalytic activity;metal ion binding,Pf01066,10390,ENSG00000134255.13,CEPT1,1,Glycerophospholipid metabolism; Ether lipid metabolism; Metabolic pathways,Kennedy pathway; One carbon metabolism and related pathways,Synthesis of PC; Synthesis of PE,11,High,1
O15455,Toll-like receptor 3 OS=Homo sapiens OX=9606 GN=TLR3 PE=1 SV=1,0.004,5.48,3,2,8,2,904,103.8,7.18,2792,,2,,cell death;defense response;metabolic process;regulation of biological process;response to stimulus,cell surface;cytoplasm;endoplasmic reticulum;endosome;membrane,protein binding;receptor activity;RNA binding;signal transducer activity,"Pf01462, Pf01582, Pf12799, Pf13306, Pf13855, Pf14580",7098,ENSG00000164342.12,TLR3,4,Herpes simplex infection; Influenza A; Hepatitis B; Hepatitis C; Toll-like receptor signaling pathway,Regulation of toll-like receptor signaling pathway; Toll-like Receptor Signaling; Toll-like receptor signaling pathway,"TRAF3 deficiency - HSE; TICAM1-dependent activation of IRF3/IRF7; TLR3 deficiency - HSE; TLR3-mediated TICAM1-dependent programmed cell death; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; TICAM1, RIP1-mediated IKK complex recruitment ; TRAF6-mediated induction of TAK1 complex within TLR4 complex; Trafficking and processing of endosomal TLR; RIP-mediated NFkB activation via ZBP1; Activated TLR4 signalling; TICAM1 deficiency - HSE; TICAM1,TRAF6-dependent induction of TAK1 complex; UNC93B1 deficiency - HSE",37,High,1
Q6ICB0,Desumoylating isopeptidase 1 OS=Homo sapiens OX=9606 GN=DESI1 PE=1 SV=1,0.004,5.477,11,2,5,2,168,18.3,4.94,1506,,2,,metabolic process,cytoplasm;nucleus,catalytic activity;protein binding,Pf05903,27351,ENSG00000100418.7,DESI1,22,,,,0,High,1
Q9NWX6,Probable tRNA(His) guanylyltransferase OS=Homo sapiens OX=9606 GN=THG1L PE=1 SV=2,0.004,5.473,6,2,3,2,298,34.8,8,1307,,2,,cell organization and biogenesis;metabolic process,cytoplasm;cytosol;mitochondrion,catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding,"Pf04446, Pf14413",54974,ENSG00000113272.13,THG1L,5,,,tRNA modification in the nucleus and cytosol,3,High,1
Q9Y2S6,Translation machinery-associated protein 7 OS=Homo sapiens OX=9606 GN=TMA7 PE=1 SV=1,0.004,5.459,14,1,67,1,64,7.1,9.99,27869,,1,,,,,,51372,ENSG00000232112.3,TMA7,3,,,,0,High,1
Q92562,Polyphosphoinositide phosphatase OS=Homo sapiens OX=9606 GN=FIG4 PE=1 SV=1,0.004,5.454,2,2,6,2,907,103.6,6.92,3474,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;endosome;Golgi;membrane,catalytic activity;protein binding;receptor activity;signal transducer activity,Pf02383,9896,ENSG00000112367.10,FIG4,6,,,Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane,7,High,1
P05114,Non-histone chromosomal protein HMG-14 OS=Homo sapiens OX=9606 GN=HMGN1 PE=1 SV=3,0.004,5.445,11,1,6,1,100,10.7,9.6,3320,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;nucleus,DNA binding;protein binding,,3150,ENSG00000205581.10,HMGN1,21,Herpes simplex infection,ATM Signaling Network in Development and Disease; p38 MAPK Signaling Pathway,Dual incision in TC-NER; Formation of TC-NER Pre-Incision Complex; Gap-filling DNA repair synthesis and ligation in TC-NER,9,High,1
Q96GY0,Zinc finger C2HC domain-containing protein 1A OS=Homo sapiens OX=9606 GN=ZC2HC1A PE=1 SV=2,0.004,5.431,4,1,5,1,325,35.1,9.82,2426,,1,,,,metal ion binding;protein binding,Pf13913,51101,ENSG00000104427.11,ZC2HC1A,8,,,,0,High,1
A2RUB6,Coiled-coil domain-containing protein 66 OS=Homo sapiens OX=9606 GN=CCDC66 PE=1 SV=4,0.004,5.429,1,1,4,1,948,109.3,8.25,2233,,1,,,,,Pf15236,285331,ENSG00000180376.16,CCDC66,3,,,,0,High,1
Q70CQ2,Ubiquitin carboxyl-terminal hydrolase 34 OS=Homo sapiens OX=9606 GN=USP34 PE=1 SV=2,0.004,5.428,0,2,12,2,3546,404,5.82,3162,,2,,metabolic process;regulation of biological process;response to stimulus,cytosol,catalytic activity;protein binding,"Pf00443, Pf13423",9736,ENSG00000115464.14,USP34,2,,,Ub-specific processing proteases; TCF dependent signaling in response to WNT,7,High,1
Q6EEV4,"DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5 OS=Homo sapiens OX=9606 GN=POLR2M PE=1 SV=1",0.004,5.427,16,1,3,1,148,15.1,8.37,1128,,1,,metabolic process,,catalytic activity,,81488,ENSG00000255529.7,POLR2M,15,,,,0,High,1
O95159,Zinc finger protein-like 1 OS=Homo sapiens OX=9606 GN=ZFPL1 PE=1 SV=2,0.004,5.418,3,1,7,1,310,34.1,8.07,4392,,1,,regulation of biological process;transport,Golgi;membrane;nucleus,DNA binding;metal ion binding,,7542,ENSG00000162300.11,ZFPL1,11,,,,0,High,1
Q96LU5,Mitochondrial inner membrane protease subunit 1 OS=Homo sapiens OX=9606 GN=IMMP1L PE=2 SV=1,0.004,5.414,11,2,11,2,166,18.5,8.09,3916,,2,,cell organization and biogenesis;metabolic process,membrane;mitochondrion,catalytic activity,"Pf00717, Pf10502",196294,ENSG00000148950.9,IMMP1L,11,Protein export,,,1,High,1
O95631,Netrin-1 OS=Homo sapiens OX=9606 GN=NTN1 PE=1 SV=2,0.004,5.413,3,1,5,1,604,67.7,8.76,1579,,1,,cell death;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cytoplasm;extracellular,protein binding,"Pf00053, Pf00055, Pf00754, Pf01759",9423,ENSG00000065320.8,NTN1,17,Axon guidance,Spinal Cord Injury,DCC mediated attractive signaling; Netrin mediated repulsion signals; Regulation of commissural axon pathfinding by SLIT and ROBO; Role of second messengers in netrin-1 signaling; DSCAM interactions,11,High,1
Q8WU10,Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PYROXD1 PE=1 SV=1,0.004,5.41,4,1,1,1,500,55.8,5.85,483,,1,,metabolic process;response to stimulus,cytoplasm;nucleus,catalytic activity;protein binding,Pf07992,79912,ENSG00000121350.15,PYROXD1,12,,,,0,High,1
Q8N4H5,Mitochondrial import receptor subunit TOM5 homolog OS=Homo sapiens OX=9606 GN=TOMM5 PE=1 SV=1,0.004,5.405,27,2,9,2,51,6,9.7,1737,,2,,cell communication;metabolic process;response to stimulus;transport,membrane;mitochondrion,transporter activity,Pf15178,401505,ENSG00000175768.12,TOMM5,9,,,Mitochondrial protein import; Metabolism of proteins; Pink/Parkin Mediated Mitophagy,4,High,1
P18065,Insulin-like growth factor-binding protein 2 OS=Homo sapiens OX=9606 GN=IGFBP2 PE=1 SV=2,0.004,5.398,3,1,5,1,325,34.8,7.5,3073,,1,,metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,protein binding,"Pf00086, Pf00219",3485,ENSG00000115457.9,IGFBP2,2,,Myometrial Relaxation and Contraction Pathways; Photodynamic therapy-induced HIF-1 survival signaling,Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs),4,High,1
Q7Z3F1,Integral membrane protein GPR155 OS=Homo sapiens OX=9606 GN=GPR155 PE=2 SV=2,0.004,5.394,1,1,4,1,870,96.9,6.84,1922,,1,,regulation of biological process;response to stimulus;transport,cytoplasm;membrane,,"Pf00610, Pf03547",151556,ENSG00000163328.13,GPR155,2,,,,0,High,1
Q6UXG8,Butyrophilin-like protein 9 OS=Homo sapiens OX=9606 GN=BTNL9 PE=2 SV=1,0.004,5.384,4,1,1,1,535,59.7,6.44,456,,1,,,membrane,protein binding,"Pf00622, Pf13765",153579,ENSG00000165810.16,BTNL9,5,,,Butyrophilin (BTN) family interactions,3,High,1
P16260,Graves disease carrier protein OS=Homo sapiens OX=9606 GN=SLC25A16 PE=1 SV=3,0.004,5.376,3,1,5,1,332,36.2,9.85,2777,,1,,metabolic process;transport,membrane;mitochondrion,transporter activity,Pf00153,8034,ENSG00000122912.14,SLC25A16,10,,,Coenzyme A biosynthesis,5,High,1
Q01415,N-acetylgalactosamine kinase OS=Homo sapiens OX=9606 GN=GALK2 PE=1 SV=1,0.004,5.369,2,1,4,1,458,50.3,6.61,2031,,1,,metabolic process,cytoplasm,catalytic activity;nucleotide binding,"Pf08544, Pf10509",2585,ENSG00000156958.14,GALK2,15,,,,0,High,1
O60683,Peroxisome biogenesis factor 10 OS=Homo sapiens OX=9606 GN=PEX10 PE=1 SV=1,0.004,5.368,4,1,4,1,326,37,9.99,1127,,1,,cell organization and biogenesis;metabolic process;transport,membrane,catalytic activity;metal ion binding;protein binding,"Pf00097, Pf04757, Pf12678, Pf12861, Pf13445, Pf13639, Pf13920, Pf13923, Pf14634, Pf15227",5192,ENSG00000157911.9,PEX10,1,Peroxisome,,E3 ubiquitin ligases ubiquitinate target proteins,5,High,1
Q8N6L1,Keratinocyte-associated protein 2 OS=Homo sapiens OX=9606 GN=KRTCAP2 PE=1 SV=2,0.004,5.362,13,1,4,1,136,14.7,9.61,1403,,1,,metabolic process,endoplasmic reticulum;membrane,,Pf09775,200185,,KRTCAP2,1,,,,0,High,1
Q9Y6X3,MAU2 chromatid cohesion factor homolog OS=Homo sapiens OX=9606 GN=MAU2 PE=1 SV=2,0.004,5.355,1,1,3,1,613,69,7.25,1837,,1,,cell division;cell organization and biogenesis,chromosome;nucleus,DNA binding;protein binding,"Pf10345, Pf13414, Pf13424",23383,ENSG00000129933.20,MAU2,19,,,Cohesin Loading onto Chromatin,5,High,1
Q5TA45,Integrator complex subunit 11 OS=Homo sapiens OX=9606 GN=INTS11 PE=1 SV=2,0.004,5.344,3,2,8,2,600,67.6,8.06,2228,,2,,metabolic process,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,"Pf00753, Pf07521, Pf10996, Pf12706",54973,ENSG00000127054.20,CPSF3L; INTS11,1,,,RNA polymerase II transcribes snRNA genes,3,High,1
Q9NYM9,BET1-like protein OS=Homo sapiens OX=9606 GN=BET1L PE=1 SV=1,0.004,5.342,19,1,1,1,111,12.4,8.16,592,,1,,cell organization and biogenesis;regulation of biological process;transport,cytosol;endosome;Golgi;membrane,protein binding,Pf05739,51272,ENSG00000177951.17,BET1L,11,SNARE interactions in vesicular transport,,COPI-mediated anterograde transport; Intra-Golgi traffic,11,High,1
Q38SD2,Leucine-rich repeat serine/threonine-protein kinase 1 OS=Homo sapiens OX=9606 GN=LRRK1 PE=1 SV=3,0.004,5.34,0,1,6,1,2015,225.2,6.68,2985,,1,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;mitochondrion,catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,"Pf00025, Pf00069, Pf07714, Pf08477, Pf12796, Pf12799, Pf13637, Pf13855",79705,ENSG00000154237.12,LRRK1,15,,,,0,High,1
Q9ULX3,RNA-binding protein NOB1 OS=Homo sapiens OX=9606 GN=NOB1 PE=1 SV=1,0.004,5.338,6,2,2,2,412,46.6,7.18,699,,2,,metabolic process,cytosol;nucleus,catalytic activity;metal ion binding,"Pf08772, Pf15017",28987,ENSG00000141101.12,NOB1,16,Ribosome biogenesis in eukaryotes,,Major pathway of rRNA processing in the nucleolus and cytosol,5,High,1
Q9ULU4,Protein kinase C-binding protein 1 OS=Homo sapiens OX=9606 GN=ZMYND8 PE=1 SV=2,0.004,5.338,2,2,3,2,1186,131.6,7.2,801,,2,,metabolic process;regulation of biological process,cytoplasm;nucleus,DNA binding;metal ion binding;protein binding,"Pf00439, Pf00628, Pf00855, Pf01753, Pf12064",23613,ENSG00000101040.19,ZMYND8,20,,,,0,High,1
Q6P158,Putative ATP-dependent RNA helicase DHX57 OS=Homo sapiens OX=9606 GN=DHX57 PE=1 SV=2,0.004,5.332,2,2,2,2,1386,155.5,7.71,676,,2,,metabolic process,mitochondrion,catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding,"Pf00270, Pf00271, Pf00642, Pf04408, Pf07717, Pf13191",90957,ENSG00000163214.20,DHX57,2,,,,0,High,1
Q9P2K3,REST corepressor 3 OS=Homo sapiens OX=9606 GN=RCOR3 PE=1 SV=2,0.003,5.332,2,1,5,1,495,55.5,8.27,1358,,1,,metabolic process;regulation of biological process,nucleus,DNA binding;protein binding,"Pf00249, Pf01448",55758,ENSG00000117625.13,RCOR3,1,,,,0,High,1
Q9C0B5,Palmitoyltransferase ZDHHC5 OS=Homo sapiens OX=9606 GN=ZDHHC5 PE=1 SV=2,0.003,5.33,4,2,2,2,715,77.5,9.01,584,,2,,metabolic process,cytoplasm;membrane,catalytic activity;metal ion binding,Pf01529,25921,ENSG00000156599.10,ZDHHC5,11,,,,0,High,1
Q6P1Q9,tRNA N(3)-methylcytidine methyltransferase METTL2B OS=Homo sapiens OX=9606 GN=METTL2B PE=1 SV=3,0.003,5.326,3,1,2,1,378,43.4,5.86,987,,1,,metabolic process,,catalytic activity,"Pf01209, Pf08241, Pf08242, Pf12847, Pf13489, Pf13649, Pf13659, Pf13847",55798,ENSG00000165055.15,METTL2B,7,,,,0,High,1
Q5M775,Cytospin-B OS=Homo sapiens OX=9606 GN=SPECC1 PE=1 SV=1,0.003,5.316,1,1,2,1,1068,118.5,6.7,935,,1,,cell organization and biogenesis;metabolic process;transport,cytoskeleton;Golgi;membrane;nucleus,catalytic activity;motor activity;protein binding;transporter activity,"Pf00307, Pf01496, Pf01576, Pf02463, Pf03962, Pf04111, Pf04156, Pf05478, Pf05667, Pf06160, Pf07888, Pf09730, Pf10174, Pf11971, Pf12128",92521,ENSG00000128487.16,SPECC1,17,,,,0,High,1
Q8TEA1,tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 OS=Homo sapiens OX=9606 GN=NSUN6 PE=1 SV=1,0.003,5.315,3,2,28,2,469,51.7,7.96,9026,0,2,1,metabolic process,cytoplasm;cytosol,catalytic activity;RNA binding,"Pf01189, Pf01472, Pf01728, Pf05175, Pf12847, Pf13659, Pf13847",221078,ENSG00000241058.3,NSUN6,10,,,tRNA modification in the nucleus and cytosol,3,High,1
Q9H1C7,Cysteine-rich and transmembrane domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CYSTM1 PE=1 SV=1,0.003,5.315,11,2,4,2,97,10.6,4.32,1027,,2,,transport,membrane,,,84418,ENSG00000120306.9,CYSTM1,5,,,Neutrophil degranulation,3,High,1
Q9Y4F3,Meiosis regulator and mRNA stability factor 1 OS=Homo sapiens OX=9606 GN=MARF1 PE=1 SV=6,0.003,5.31,1,2,17,2,1742,192.7,7.87,7376,,2,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,Golgi;membrane,RNA binding,"Pf00076, Pf01936, Pf11608, Pf12872, Pf13893, Pf14259",9665,ENSG00000166783.21; ENSG00000277140.2,KIAA0430; MARF1,16; CHR_HSCHR16_1_CTG1,,,,0,High,1
P18887,DNA repair protein XRCC1 OS=Homo sapiens OX=9606 GN=XRCC1 PE=1 SV=2,0.003,5.309,3,2,4,2,633,69.4,6.39,1751,,2,,metabolic process;regulation of biological process;response to stimulus,nucleus,catalytic activity;DNA binding;protein binding,"Pf00533, Pf01834, Pf12738",7515,,XRCC1,19,Base excision repair,,Resolution of AP sites via the single-nucleotide replacement pathway; Gap-filling DNA repair synthesis and ligation in TC-NER; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; HDR through MMEJ (alt-NHEJ); Gap-filling DNA repair synthesis and ligation in GG-NER,14,High,1
Q9Y324,rRNA-processing protein FCF1 homolog OS=Homo sapiens OX=9606 GN=FCF1 PE=2 SV=1,0.003,5.308,7,1,3,1,198,23.4,9.7,1213,,1,,metabolic process,nucleus,RNA binding,Pf04900,51077,ENSG00000119616.11,FCF1,14,Ribosome biogenesis in eukaryotes,,Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol,6,High,1
Q9H6K1,Protein ILRUN OS=Homo sapiens OX=9606 GN=ILRUN PE=1 SV=2,0.003,5.298,5,1,4,1,298,32.9,4.58,1533,,1,,cell communication;metabolic process;response to stimulus,vacuole,protein binding,Pf14555,64771,ENSG00000196821.9,C6orf106,6,,,,0,High,1
Q6P4Q7,Metal transporter CNNM4 OS=Homo sapiens OX=9606 GN=CNNM4 PE=1 SV=3,0.003,5.297,1,1,11,1,775,86.6,6.07,3954,,1,,response to stimulus;transport,membrane,protein binding;transporter activity,"Pf00571, Pf01595",26504,ENSG00000158158.11,CNNM4,2,,,,0,High,1
Q96A00,Protein phosphatase 1 regulatory subunit 14A OS=Homo sapiens OX=9606 GN=PPP1R14A PE=1 SV=1,0.003,5.289,11,1,3,1,147,16.7,9.38,1695,,1,,regulation of biological process;response to stimulus,cytoplasm;cytosol,enzyme regulator activity,Pf05361,94274,ENSG00000167641.10,PPP1R14A,19,Vascular smooth muscle contraction,,RHO GTPases activate PKNs,5,High,1
Q86W56,Poly(ADP-ribose) glycohydrolase OS=Homo sapiens OX=9606 GN=PARG PE=1 SV=1,0.003,5.285,1,1,7,1,976,111,6.43,3401,,1,,metabolic process;response to stimulus,cytoplasm;cytosol;membrane;mitochondrion;nucleus;organelle lumen,catalytic activity;protein binding,Pf05028,8505; 670,ENSG00000227345.8,PARG; BPHL,10; 6,,,POLB-Dependent Long Patch Base Excision Repair,5,High,1
Q02083,N-acylethanolamine-hydrolyzing acid amidase OS=Homo sapiens OX=9606 GN=NAAA PE=1 SV=3,0.004,5.26,5,1,3,1,359,40,8.75,1435,,1,,metabolic process;transport,cytoplasm;organelle lumen;vacuole,catalytic activity;protein binding,"Pf02275, Pf15508",27163,ENSG00000138744.14,NAAA,4,,,Neurotransmitter release cycle,3,High,1
Q13432,Protein unc-119 homolog A OS=Homo sapiens OX=9606 GN=UNC119 PE=1 SV=1,0.004,5.257,4,1,4,1,240,26.9,6.42,2010,,1,,cell communication;cell differentiation;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol,protein binding,Pf05351,9094,ENSG00000109103.11,UNC119,17,,,,0,High,1
Q9NWZ3,Interleukin-1 receptor-associated kinase 4 OS=Homo sapiens OX=9606 GN=IRAK4 PE=1 SV=1,0.004,5.236,7,2,2,2,460,51.5,5.41,546,,2,,cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf00531, Pf07714",51135,ENSG00000198001.13,IRAK4,12,NOD-like receptor signaling pathway; Toll-like receptor signaling pathway; Pertussis; Leishmaniasis; Influenza A; Chagas disease (American trypanosomiasis); Toxoplasmosis; NF-kappa B signaling pathway; Measles; Tuberculosis; Neurotrophin signaling pathway,Regulation of toll-like receptor signaling pathway; IL-1 signaling pathway; AGE/RAGE pathway; Structural Pathway of Interleukin 1 (IL-1); TLR4 Signaling and Tolerance; Toll-like Receptor Signaling; Toll-like receptor signaling pathway,"MyD88:Mal cascade initiated on plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; IRAK4 deficiency (TLR2/4); Activated TLR4 signalling; MyD88 deficiency (TLR5); Interleukin-1 family signaling; IRAK4 deficiency (TLR5); MyD88 cascade initiated on plasma membrane; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation; MyD88 deficiency (TLR2/4)",50,High,1
P52952,Homeobox protein Nkx-2.5 OS=Homo sapiens OX=9606 GN=NKX2-5 PE=1 SV=1,0.004,5.236,4,2,6,1,324,34.9,9.38,2390,,2,,cell death;cell differentiation;cell organization and biogenesis;cell proliferation;development;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,DNA binding;protein binding,Pf00046,1482,ENSG00000183072.9,NKX2-5,5,,Heart Development; SRF and miRs in Smooth Muscle Differentiation and Proliferation; Cardiac Progenitor Differentiation,YAP1- and WWTR1 (TAZ)-stimulated gene expression; Physiological factors,10,High,1
Q01638,Interleukin-1 receptor-like 1 OS=Homo sapiens OX=9606 GN=IL1RL1 PE=1 SV=4,0.004,5.23,3,1,12,1,556,63.3,8.35,7075,,1,,regulation of biological process;response to stimulus,extracellular;membrane,protein binding;receptor activity;signal transducer activity,"Pf01582, Pf07679",9173,ENSG00000115602.16,IL1RL1,2,,,"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Interleukin-33 signaling",10,High,1
O43761,Synaptogyrin-3 OS=Homo sapiens OX=9606 GN=SYNGR3 PE=1 SV=2,0.004,5.223,7,1,3,1,229,24.5,8.18,1542,,1,,regulation of biological process;transport,membrane,protein binding,Pf01284,9143,ENSG00000127561.14,SYNGR3,16,,,,0,High,1
Q8IV36,Protein HID1 OS=Homo sapiens OX=9606 GN=HID1 PE=1 SV=1,0.004,5.221,3,1,2,1,788,88.7,6.06,1148,,1,,response to stimulus;transport,cytoplasm;cytosol;Golgi;membrane,protein binding,"Pf09742, Pf12722",283987,ENSG00000167861.15,HID1,17,,,,0,High,1
Q96GM8,Target of EGR1 protein 1 OS=Homo sapiens OX=9606 GN=TOE1 PE=1 SV=1,0.004,5.22,3,2,21,2,510,56.5,7.18,8520,,2,,metabolic process,cytoplasm;nucleus,catalytic activity;metal ion binding;protein binding;RNA binding,"Pf00642, Pf04857",114034,ENSG00000132773.11,TOE1,1,,,,0,High,1
Q9UK76,Jupiter microtubule associated homolog 1 OS=Homo sapiens OX=9606 GN=JPT1 PE=1 SV=3,0.004,5.213,10,1,2,1,154,16,5.6,1053,,1,,,cytoplasm;membrane;nucleus,,,51155,ENSG00000189159.15,HN1; JPT1,17,,,,0,High,1
A0A075B6I9,Immunoglobulin lambda variable 7-46 OS=Homo sapiens OX=9606 GN=IGLV7-46 PE=3 SV=4,0.004,5.209,8,1,35,1,117,12.5,7.2,15965,,1,,response to stimulus,extracellular;membrane,,,28775,ENSG00000211649.3,IGLV7-46,22,,,,0,High,1
Q06278,Aldehyde oxidase OS=Homo sapiens OX=9606 GN=AOX1 PE=1 SV=2,0.004,5.203,1,2,14,2,1338,147.8,7.17,7231,,2,,metabolic process,cytoplasm;cytosol,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00941, Pf01315, Pf01799, Pf02738, Pf03450",316,ENSG00000138356.13,AOX1,2,"Valine, leucine and isoleucine degradation; Jak-STAT signaling pathway; Metabolic pathways; Retinol metabolism; Vitamin B6 metabolism; Tryptophan metabolism; Nicotinate and nicotinamide metabolism; Drug metabolism - cytochrome P450; Tyrosine metabolism",Nicotine Metabolism; Effects of Nitric Oxide; Tryptophan metabolism,Vitamins B6 activation to pyridoxal phosphate,16,High,1
Q9BY89,Uncharacterized protein KIAA1671 OS=Homo sapiens OX=9606 GN=KIAA1671 PE=1 SV=2,0.004,5.192,2,2,6,2,1806,196.6,8.47,1693,,2,,,,,Pf15327,85379,ENSG00000197077.13,KIAA1671,22,,,,0,High,1
Q8NF37,Lysophosphatidylcholine acyltransferase 1 OS=Homo sapiens OX=9606 GN=LPCAT1 PE=1 SV=2,0.004,5.19,3,1,2,1,534,59.1,6.02,627,,1,,metabolic process;regulation of biological process;transport,endoplasmic reticulum;Golgi;membrane,catalytic activity;metal ion binding,"Pf01553, Pf13833",79888,ENSG00000153395.9,LPCAT1,5,Ether lipid metabolism; Metabolic pathways; Glycerophospholipid metabolism,,Synthesis of PA; Synthesis of PC; Acyl chain remodelling of PG; Neutrophil degranulation; Acyl chain remodelling of PC,14,High,1
Q6UVY6,DBH-like monooxygenase protein 1 OS=Homo sapiens OX=9606 GN=MOXD1 PE=1 SV=1,0.004,5.185,2,1,4,1,613,69.6,6.43,2422,,1,,metabolic process,endoplasmic reticulum;membrane,catalytic activity;metal ion binding;protein binding,"Pf01082, Pf03351, Pf03712",26002,ENSG00000079931.14,MOXD1,6,,,,0,High,1
Q10472,Polypeptide N-acetylgalactosaminyltransferase 1 OS=Homo sapiens OX=9606 GN=GALNT1 PE=1 SV=1,0.004,5.183,4,2,6,2,559,64.2,7.72,1571,,2,,metabolic process,extracellular;Golgi;membrane,catalytic activity;metal ion binding,"Pf00535, Pf00652, Pf02709, Pf10111, Pf13632, Pf13641",2589,ENSG00000141429.13,GALNT1,18,Metabolic pathways; Mucin type O-glycan biosynthesis,,COPI-independent Golgi-to-ER retrograde traffic; O-linked glycosylation of mucins,11,High,1
Q9Y6N7,Roundabout homolog 1 OS=Homo sapiens OX=9606 GN=ROBO1 PE=1 SV=1,0.004,5.175,1,2,6,2,1651,180.8,6.04,1867,,2,,cell differentiation;cellular component movement;development;metabolic process;regulation of biological process;response to stimulus,cell surface;cytoplasm;membrane,protein binding;receptor activity;signal transducer activity,"Pf00041, Pf00047, Pf07679, Pf07686, Pf13895, Pf13927",6091,ENSG00000169855.19,ROBO1,3,Axon guidance,,Netrin-1 signaling; SLIT2:ROBO1 increases RHOA activity; Activation of RAC1; Regulation of expression of SLITs and ROBOs; Regulation of commissural axon pathfinding by SLIT and ROBO; Inactivation of CDC42 and RAC1; Regulation of cortical dendrite branching; Role of ABL in ROBO-SLIT signaling,12,High,1
Q8IYU2,E3 ubiquitin-protein ligase HACE1 OS=Homo sapiens OX=9606 GN=HACE1 PE=1 SV=2,0.004,5.175,1,1,4,1,909,102.3,5.92,1630,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;endoplasmic reticulum;Golgi;membrane;nucleus,catalytic activity;protein binding,"Pf00023, Pf00632, Pf12796, Pf13606, Pf13637, Pf13857",57531,ENSG00000085382.11,HACE1,6,,,Antigen processing: Ubiquitination & Proteasome degradation,4,High,1
Q92619,Rho GTPase-activating protein 45 OS=Homo sapiens OX=9606 GN=ARHGAP45 PE=1 SV=2,0.004,5.168,2,2,20,2,1136,124.5,6.1,4211,,2,,regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;membrane;organelle lumen,enzyme regulator activity;metal ion binding;protein binding,"Pf00130, Pf00611, Pf00620",23526,ENSG00000180448.10,HMHA1; ARHGAP45,19,,,Neutrophil degranulation; Rho GTPase cycle,6,High,1
Q16394,Exostosin-1 OS=Homo sapiens OX=9606 GN=EXT1 PE=1 SV=2,0.004,5.166,1,1,4,1,746,86.2,9.04,2070,,1,,cellular component movement;metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;Golgi;membrane,catalytic activity;metal ion binding;protein binding,"Pf03016, Pf09258",2131,ENSG00000182197.10,EXT1,8,Glycosaminoglycan biosynthesis - heparan sulfate / heparin; Metabolic pathways,Endoderm Differentiation; Mesodermal Commitment Pathway,"HS-GAG biosynthesis; Defective EXT1 causes exostoses 1, TRPS2 and CHDS",13,High,1
Q9ULD9,Zinc finger protein 608 OS=Homo sapiens OX=9606 GN=ZNF608 PE=1 SV=4,0.004,5.165,2,1,5,1,1512,162.1,8.79,2643,,1,,metabolic process;regulation of biological process,,metal ion binding,,57507,ENSG00000168916.15,ZNF608,5,,,,0,High,1
Q14517,Protocadherin Fat 1 OS=Homo sapiens OX=9606 GN=FAT1 PE=1 SV=2,0.004,5.159,0,2,9,2,4588,506,5,2786,,2,,cell communication;cell organization and biogenesis;cellular component movement,cell surface;cytoplasm;membrane;nucleus,metal ion binding;protein binding,"Pf00008, Pf00028, Pf00054, Pf02210, Pf05444, Pf06247, Pf07645, Pf12947, Pf13385",2195,ENSG00000083857.13,FAT1,4,,Primary Focal Segmental Glomerulosclerosis FSGS,,1,High,1
Q9UNH6,Sorting nexin-7 OS=Homo sapiens OX=9606 GN=SNX7 PE=1 SV=1,0.004,5.148,3,1,3,1,387,45.3,5.11,1731,,1,,cell organization and biogenesis;transport,endosome;membrane,protein binding,Pf00787,51375,,SNX7,1,,,,0,High,1
P04150,Glucocorticoid receptor OS=Homo sapiens OX=9606 GN=NR3C1 PE=1 SV=1,0.004,5.123,3,2,2,2,777,85.6,6.38,697,,2,,cell death;cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;mitochondrion;nucleus;organelle lumen,DNA binding;metal ion binding;protein binding;receptor activity;RNA binding;signal transducer activity,"Pf00104, Pf00105, Pf02155",2908,ENSG00000113580.14,NR3C1,5,Neuroactive ligand-receptor interaction,Nuclear Receptors; Adipogenesis; Endoderm Differentiation; Transcription factor regulation in adipogenesis; White fat cell differentiation; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways; Serotonin Receptor 4/6/7 and NR3C Signaling,"Regulation of RUNX2 expression and activity; Nuclear Receptor transcription pathway; HSP90 chaperone cycle for steroid hormone receptors (SHR); BMAL1:CLOCK,NPAS2 activates circadian gene expression; PTK6 Expression",23,High,1
Q6RFH5,WD repeat-containing protein 74 OS=Homo sapiens OX=9606 GN=WDR74 PE=1 SV=1,0.004,5.121,6,2,6,2,385,42.4,8.32,1638,,2,,,nucleus,protein binding,Pf00400,54663,ENSG00000133316.15,WDR74,11,,,,0,High,1
Q9ULR0,Pre-mRNA-splicing factor ISY1 homolog OS=Homo sapiens OX=9606 GN=ISY1 PE=1 SV=3,0.004,5.112,7,1,2,1,285,33,5.17,860,,1,,cell organization and biogenesis;metabolic process;response to stimulus,nucleus;spliceosomal complex,catalytic activity;protein binding;RNA binding,Pf06246,57461; 100534599,ENSG00000240682.9,ISY1; ISY1-RAB43,3,Spliceosome,,Dual incision in TC-NER; Formation of TC-NER Pre-Incision Complex; mRNA Splicing - Major Pathway; Gap-filling DNA repair synthesis and ligation in TC-NER,11,High,1
Q8NBM4,Ubiquitin-associated domain-containing protein 2 OS=Homo sapiens OX=9606 GN=UBAC2 PE=1 SV=1,0.004,5.106,3,1,3,1,344,38.9,9.01,1099,,1,,,endoplasmic reticulum;membrane,catalytic activity;protein binding,Pf00627,337867,ENSG00000134882.15,UBAC2,13,,,,0,High,1
Q32P41,tRNA (guanine(37)-N1)-methyltransferase OS=Homo sapiens OX=9606 GN=TRMT5 PE=1 SV=2,0.004,5.093,4,2,4,2,509,58.2,8.62,1036,,2,,cell organization and biogenesis;metabolic process,cytoplasm;mitochondrion;nucleus;organelle lumen,catalytic activity,"Pf02475, Pf13659",57570,,TRMT5,14,,,Synthesis of wybutosine at G37 of tRNA(Phe),4,High,1
O94992,Protein HEXIM1 OS=Homo sapiens OX=9606 GN=HEXIM1 PE=1 SV=1,0.004,5.093,2,1,4,1,359,40.6,4.89,2093,,1,,defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,enzyme regulator activity;protein binding;RNA binding,Pf15313,10614,ENSG00000186834.3,HEXIM1,17,,Initiation of transcription and translation elongation at the HIV-1 LTR,,1,High,1
A0A0B4J1V2,Immunoglobulin heavy variable 2-26 OS=Homo sapiens OX=9606 GN=IGHV2-26 PE=3 SV=1,0.004,5.092,12,1,4,1,119,13.2,8.29,1824,,1,,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,protein binding,,28455,ENSG00000282344.1; ENSG00000211951.2,IGHV2-26,14; CHR_HSCHR14_3_CTG1,,,,0,High,1
D6RBQ6,Ubiquitin carboxyl-terminal hydrolase 17-like protein 17 OS=Homo sapiens OX=9606 GN=USP17L17 PE=3 SV=1,0.004,5.087,1,1,21,1,530,59.6,7.99,8320,,1,,metabolic process,endoplasmic reticulum;nucleus,catalytic activity,"Pf00443, Pf04774, Pf13423",100287327,ENSG00000249104.2,USP17L17,4,,,Ub-specific processing proteases,4,High,1
Q8NFZ5,TNFAIP3-interacting protein 2 OS=Homo sapiens OX=9606 GN=TNIP2 PE=1 SV=1,0.004,5.087,3,1,2,1,429,48.7,6.44,842,,1,,cell death;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,metal ion binding;protein binding,"Pf09731, Pf12180",79155,ENSG00000168884.14,TNIP2,4,,Rac1/Pak1/p38/MMP-2 pathway,Ovarian tumor domain proteases; MAP3K8 (TPL2)-dependent MAPK1/3 activation; Activated TLR4 signalling; Interleukin-1 family signaling,30,High,1
Q13356,RING-type E3 ubiquitin-protein ligase PPIL2 OS=Homo sapiens OX=9606 GN=PPIL2 PE=1 SV=1,0.004,5.086,2,1,4,1,520,58.8,8.78,1908,,1,,cell organization and biogenesis;cellular component movement;metabolic process,cytoplasm;membrane;nucleus;organelle lumen,catalytic activity;protein binding,"Pf00160, Pf04641",23759,ENSG00000100023.18,PPIL2,22,Ubiquitin mediated proteolysis,,Basigin interactions,4,High,1
P49848,Transcription initiation factor TFIID subunit 6 OS=Homo sapiens OX=9606 GN=TAF6 PE=1 SV=1,0.004,5.075,3,2,3,2,677,72.6,8.6,928,,2,,metabolic process;regulation of biological process,cytosol;nucleus,DNA binding;protein binding,"Pf02969, Pf07571",6878,ENSG00000106290.14,TAF6,7,Herpes simplex infection; Basal transcription factors,Eukaryotic Transcription Initiation,RNA polymerase II transcribes snRNA genes; RNA Polymerase II Transcription Initiation; HIV Transcription Initiation; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; RNA Polymerase II Promoter Escape,23,High,1
Q96SY0,Integrator complex subunit 14 OS=Homo sapiens OX=9606 GN=INTS14 PE=1 SV=2,0.004,5.073,5,2,6,2,518,57.4,5.12,1462,,2,,metabolic process,nucleus,,Pf13519,81556,ENSG00000138614.14,VWA9; INTS14,15,,,RNA polymerase II transcribes snRNA genes,3,High,1
Q14314,Fibroleukin OS=Homo sapiens OX=9606 GN=FGL2 PE=1 SV=1,0.004,5.069,5,1,7,1,439,50.2,7.39,2007,,1,,metabolic process;transport,extracellular,catalytic activity,"Pf00147, Pf02994",10875,ENSG00000127951.6,FGL2,7,,,Neutrophil degranulation,3,High,1
Q13214,Semaphorin-3B OS=Homo sapiens OX=9606 GN=SEMA3B PE=2 SV=1,0.004,5.067,2,2,22,1,749,83.1,8.91,9037,,2,,cell communication;cellular component movement;response to stimulus,endoplasmic reticulum;extracellular;membrane,protein binding,"Pf01403, Pf01437",7869,ENSG00000012171.19,SEMA3B,3,Axon guidance,,,1,High,1
Q9Y4K1,Beta/gamma crystallin domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CRYBG1 PE=1 SV=3,0.004,5.067,1,2,20,2,1723,188.6,5.86,8591,,2,,,,,"Pf00030, Pf00652",202,ENSG00000112297.14,AIM1; CRYBG1,6,,,,0,High,1
P59768,Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 OS=Homo sapiens OX=9606 GN=GNG2 PE=1 SV=2,0.004,5.056,23,1,5,1,71,7.8,7.99,2302,,1,,cell proliferation;metabolic process;regulation of biological process;response to stimulus,membrane,protein binding;signal transducer activity,Pf00631,54331,ENSG00000186469.8,GNG2,14,Retrograde endocannabinoid signaling; Glutamatergic synapse; Ras signaling pathway; Morphine addiction; Dopaminergic synapse; Cholinergic synapse; GABAergic synapse; Pathways in cancer; PI3K-Akt signaling pathway; Circadian entrainment; Chemokine signaling pathway; Serotonergic synapse; Alcoholism,Nicotine Activity on Dopaminergic Neurons; Human Thyroid Stimulating Hormone (TSH) signaling pathway; Myometrial Relaxation and Contraction Pathways; Chemokine signaling pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Calcium Regulation in the Cardiac Cell,"G alpha (z) signalling events; Activation of G protein gated Potassium channels; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; ADP signalling through P2Y purinoceptor 1; G beta:gamma signalling through PI3Kgamma; Vasopressin regulates renal water homeostasis via Aquaporins; G-protein activation; Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits; G alpha (12/13) signalling events; G alpha (s) signalling events; Ca2+ pathway; ADP signalling through P2Y purinoceptor 12; Adrenaline,noradrenaline inhibits insulin secretion; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Presynaptic function of Kainate receptors; G beta:gamma signalling through PLC beta; Glucagon signaling in metabolic regulation; Thrombin signalling through proteinase activated receptors (PARs); Prostacyclin signalling through prostacyclin receptor; Gastrin-CREB signalling pathway via PKC and MAPK",74,High,1
O15213,WD repeat-containing protein 46 OS=Homo sapiens OX=9606 GN=WDR46 PE=1 SV=3,0.004,5.055,9,2,12,2,610,68,9.67,3083,,2,,metabolic process,nucleus,protein binding;RNA binding,"Pf00400, Pf08149",9277,ENSG00000227057.9,WDR46,6,,,Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol,5,High,1
Q9NV66,S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 OS=Homo sapiens OX=9606 GN=TYW1 PE=2 SV=2,0.004,5.054,2,1,1,1,732,83.6,6.87,507,,1,,metabolic process,,catalytic activity;metal ion binding;nucleotide binding,"Pf00258, Pf04055, Pf08608",55253,ENSG00000198874.12,TYW1,7,,,Synthesis of wybutosine at G37 of tRNA(Phe),4,High,1
Q9GZL7,Ribosome biogenesis protein WDR12 OS=Homo sapiens OX=9606 GN=WDR12 PE=1 SV=2,0.004,5.035,4,2,3,2,423,47.7,5.9,719,,2,,cell proliferation;metabolic process;regulation of biological process;response to stimulus,nucleus,protein binding,"Pf00400, Pf08154",55759,ENSG00000138442.9,WDR12,2,,,Major pathway of rRNA processing in the nucleolus and cytosol,4,High,1
Q8N9A8,Nuclear envelope phosphatase-regulatory subunit 1 OS=Homo sapiens OX=9606 GN=CNEP1R1 PE=1 SV=1,0.004,5.028,16,2,9,2,125,14.3,8.38,2856,,2,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;nucleus,protein binding,Pf09771,255919,ENSG00000205423.11,CNEP1R1,16,,,Depolymerisation of the Nuclear Lamina,6,High,1
Q04721,Neurogenic locus notch homolog protein 2 OS=Homo sapiens OX=9606 GN=NOTCH2 PE=1 SV=3,0.004,5.026,0,1,6,1,2471,265.2,5.14,2398,,1,,cell death;cell differentiation;development;metabolic process;regulation of biological process;response to stimulus,cell surface;cytoplasm;extracellular;membrane;nucleus,metal ion binding;protein binding;receptor activity;signal transducer activity,"Pf00008, Pf00023, Pf00066, Pf06247, Pf06816, Pf07223, Pf07645, Pf07684, Pf09770, Pf11936, Pf12796, Pf13136, Pf13606, Pf13637, Pf13857",4853,ENSG00000134250.19,NOTCH2,1,Notch signaling pathway; Dorso-ventral axis formation; Breast cancer; Endocrine resistance; Thyroid hormone signaling pathway; MicroRNAs in cancer; Th1 and Th2 cell differentiation,Neural Crest Differentiation; Notch Signaling Pathway; Canonical  and Non-canonical Notch signaling; Role of Osx and miRNAs in tooth development; Notch Signaling Pathway,NOTCH2 Activation and Transmission of Signal to the Nucleus; Defective LFNG causes SCDO3; Pre-NOTCH Processing in Golgi; Notch-HLH transcription pathway; Pre-NOTCH Transcription and Translation; Pre-NOTCH Processing in the Endoplasmic Reticulum; NOTCH2 intracellular domain regulates transcription,29,High,1
Q15025,TNFAIP3-interacting protein 1 OS=Homo sapiens OX=9606 GN=TNIP1 PE=1 SV=2,0.004,5.025,3,2,3,2,636,71.8,6.62,868,,2,,cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;motor activity;nucleotide binding;protein binding;structural molecule activity,"Pf00038, Pf01576, Pf02841, Pf03938, Pf03961, Pf04111, Pf04156, Pf10079, Pf10211, Pf13654, Pf13851, Pf14362",10318,ENSG00000145901.14,TNIP1,5,,Rac1/Pak1/p38/MMP-2 pathway,Ovarian tumor domain proteases,5,High,1
Q92908,Transcription factor GATA-6 OS=Homo sapiens OX=9606 GN=GATA6 PE=1 SV=2,0.004,5.017,2,1,3,1,595,60,8.35,1429,,1,,cell differentiation;coagulation;metabolic process;regulation of biological process;response to stimulus,membrane;nucleus,DNA binding;metal ion binding;protein binding,"Pf00320, Pf05349",2627,ENSG00000141448.8,GATA6,18,,Heart Development; Endoderm Differentiation; Mesodermal Commitment Pathway; Ectoderm Differentiation,Surfactant metabolism; Factors involved in megakaryocyte development and platelet production,8,High,1
O43543,DNA repair protein XRCC2 OS=Homo sapiens OX=9606 GN=XRCC2 PE=1 SV=1,0.004,5.014,10,1,1,1,280,31.9,6.04,693,,1,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding,Pf08423,7516,ENSG00000196584.2,XRCC2,7,Homologous recombination,,Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA),11,High,1
Q93015,N-alpha-acetyltransferase 80 OS=Homo sapiens OX=9606 GN=NAA80 PE=1 SV=2,0.004,5.007,4,1,11,1,286,31.4,7.85,4873,,1,,,cytoplasm,catalytic activity,Pf00583,24142,ENSG00000243477.5,NAT6,3,,,,0,High,1
Q96PZ0,Pseudouridylate synthase 7 homolog OS=Homo sapiens OX=9606 GN=PUS7 PE=1 SV=2,0.004,5.007,2,1,3,1,661,75,6.37,1034,,1,,metabolic process,nucleus,catalytic activity;protein binding;RNA binding,Pf01142,54517,ENSG00000091127.13,PUS7,7,,,tRNA modification in the nucleus and cytosol,3,High,1
Q15554,Telomeric repeat-binding factor 2 OS=Homo sapiens OX=9606 GN=TERF2 PE=1 SV=3,0.004,5.005,4,2,2,2,542,59.6,9.35,584,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;nucleus,catalytic activity;DNA binding;protein binding,"Pf00249, Pf08558, Pf13921",7014,ENSG00000132604.10,TERF2,16,,Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex,Meiotic synapsis; DNA Damage/Telomere Stress Induced Senescence; Packaging Of Telomere Ends,12,High,1
A0A075B6I0,Immunoglobulin lambda variable 8-61 OS=Homo sapiens OX=9606 GN=IGLV8-61 PE=3 SV=7,0.004,5.004,7,1,4,1,122,12.8,4.55,1078,0,1,1,response to stimulus,extracellular;membrane,,,28774,ENSG00000211638.2,IGLV8-61,22,,,,0,High,1
Q9BR61,Acyl-CoA-binding domain-containing protein 6 OS=Homo sapiens OX=9606 GN=ACBD6 PE=1 SV=1,0.004,5.003,5,1,5,1,282,31.1,5.11,1447,,1,,metabolic process,cytoplasm;cytosol,protein binding,"Pf00023, Pf00887, Pf12796, Pf13606, Pf13637, Pf13857",84320,ENSG00000230124.6,ACBD6,1,,,Mitochondrial Fatty Acid Beta-Oxidation,4,High,1
P31276,Homeobox protein Hox-C13 OS=Homo sapiens OX=9606 GN=HOXC13 PE=1 SV=3,0.004,4.992,5,2,5,1,330,35.4,8.95,1779,,2,,development;metabolic process;regulation of biological process,nucleus,DNA binding;protein binding,"Pf00046, Pf05920",3229,ENSG00000123364.4,HOXC13,12,,,,0,High,1
Q9UNY4,Transcription termination factor 2 OS=Homo sapiens OX=9606 GN=TTF2 PE=1 SV=2,0.004,4.986,2,2,4,2,1162,129.5,8.37,1194,,2,,metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus;spliceosomal complex,catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding,"Pf00176, Pf00271, Pf06839",8458,ENSG00000116830.11,TTF2,1,Thyroid hormone synthesis,Human Thyroid Stimulating Hormone (TSH) signaling pathway,,2,High,1
Q00403,Transcription initiation factor IIB OS=Homo sapiens OX=9606 GN=GTF2B PE=1 SV=1,0.004,4.979,6,1,3,1,316,34.8,8.35,986,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,nucleus,DNA binding;metal ion binding;protein binding,"Pf00382, Pf08271",2959,ENSG00000137947.11,GTF2B,1,Basal transcription factors; Epstein-Barr virus infection; Viral carcinogenesis,Eukaryotic Transcription Initiation,RNA polymerase II transcribes snRNA genes; RNA Polymerase II Transcription Initiation; HIV Transcription Initiation; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Pre-transcription Events; RNA Polymerase II Promoter Escape,20,High,1
Q9NY12,H/ACA ribonucleoprotein complex subunit 1 OS=Homo sapiens OX=9606 GN=GAR1 PE=1 SV=1,0.004,4.979,4,1,5,1,217,22.3,10.92,1393,0,1,1,cell organization and biogenesis;metabolic process,nucleus,protein binding;RNA binding,Pf04410,54433,ENSG00000109534.16,GAR1,4,Ribosome biogenesis in eukaryotes,,rRNA modification in the nucleus and cytosol,5,High,1
O94885,SAM and SH3 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SASH1 PE=1 SV=3,0.004,4.973,4,2,2,2,1247,136.6,6.09,588,,2,,metabolic process;regulation of biological process,,protein binding;structural molecule activity,"Pf00536, Pf07647, Pf12485",23328,ENSG00000111961.17,SASH1,6,,,,0,High,1
P78383,Solute carrier family 35 member B1 OS=Homo sapiens OX=9606 GN=SLC35B1 PE=1 SV=1,0.004,4.971,3,1,4,1,322,35.7,9.26,1960,,1,,transport,endoplasmic reticulum;membrane,transporter activity,"Pf03151, Pf08449",10237,,SLC35B1,17,,,,0,High,1
Q13686,Nucleic acid dioxygenase ALKBH1 OS=Homo sapiens OX=9606 GN=ALKBH1 PE=1 SV=2,0.004,4.965,2,1,1,1,389,43.8,7.08,588,,1,,cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,mitochondrion;nucleus,catalytic activity;metal ion binding;RNA binding,Pf13532,8846,ENSG00000100601.9,ALKBH1,14,,,,0,High,1
O00566,U3 small nucleolar ribonucleoprotein protein MPP10 OS=Homo sapiens OX=9606 GN=MPHOSPH10 PE=1 SV=2,0.004,4.964,3,1,2,1,681,78.8,4.86,1104,,1,,metabolic process;regulation of biological process,chromosome;nucleus,protein binding;RNA binding,Pf04006,10199,ENSG00000124383.8,MPHOSPH10,2,Ribosome biogenesis in eukaryotes,,Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol,6,High,1
P30260,Cell division cycle protein 27 homolog OS=Homo sapiens OX=9606 GN=CDC27 PE=1 SV=2,0.005,4.96,2,2,4,2,824,91.8,7.02,1111,,2,,cell proliferation;metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,protein binding,"Pf00515, Pf05109, Pf07719, Pf12895, Pf13181, Pf13414, Pf13424, Pf13431, Pf13432, Pf14559",996,ENSG00000004897.11,CDC27,17,Cell cycle; Ubiquitin mediated proteolysis; HTLV-I infection; Oocyte meiosis; Progesterone-mediated oocyte maturation,,APC/C:Cdc20 mediated degradation of Cyclin B; Inactivation of APC/C via direct inhibition of the APC/C complex; Autodegradation of Cdh1 by Cdh1:APC/C; APC-Cdc20 mediated degradation of Nek2A; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Antigen processing: Ubiquitination & Proteasome degradation; Phosphorylation of the APC/C; APC/C:Cdc20 mediated degradation of Securin; Separation of Sister Chromatids; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Senescence-Associated Secretory Phenotype (SASP),37,High,1
Q96KJ9,"Cytochrome c oxidase subunit 4 isoform 2, mitochondrial OS=Homo sapiens OX=9606 GN=COX4I2 PE=1 SV=2",0.005,4.96,6,1,7,1,171,20,9.63,2883,,1,,metabolic process;response to stimulus;transport,membrane;mitochondrion,catalytic activity;transporter activity,Pf02936,84701,ENSG00000131055.4,COX4I2,20,Non-alcoholic fatty liver disease (NAFLD); Parkinson's disease; Cardiac muscle contraction; Oxidative phosphorylation; Huntington's disease; Metabolic pathways; Alzheimer's disease,,,7,High,1
O95361,Tripartite motif-containing protein 16 OS=Homo sapiens OX=9606 GN=TRIM16 PE=1 SV=3,0.005,4.96,5,2,2,1,564,63.9,5.49,535,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,DNA binding;metal ion binding;protein binding,"Pf00622, Pf13765",10626,ENSG00000221926.11,TRIM16,17,,,,0,High,1
O95801,Tetratricopeptide repeat protein 4 OS=Homo sapiens OX=9606 GN=TTC4 PE=1 SV=3,0.005,4.954,3,1,4,1,387,44.7,5.6,1503,,1,,,,protein binding,"Pf13414, Pf13432",7268,ENSG00000243725.6,TTC4,1,,,,0,High,1
Q96KC2,ADP-ribosylation factor-like protein 5B OS=Homo sapiens OX=9606 GN=ARL5B PE=1 SV=1,0.005,4.953,12,2,7,1,179,20.4,6.52,1391,,2,,cell organization and biogenesis;regulation of biological process;response to stimulus,,catalytic activity;nucleotide binding;protein binding;signal transducer activity,"Pf00025, Pf00071, Pf00503, Pf01926, Pf04670, Pf08477, Pf09439",221079,ENSG00000165997.4,ARL5B,10,,,,0,High,1
O00189,AP-4 complex subunit mu-1 OS=Homo sapiens OX=9606 GN=AP4M1 PE=1 SV=2,0.005,4.952,3,1,2,1,453,49.9,7.2,732,,1,,cell organization and biogenesis;transport,cytosol;endosome;Golgi;membrane;organelle lumen,protein binding,Pf00928,9179,ENSG00000221838.9,AP4M1,7,Lysosome,,Lysosome Vesicle Biogenesis,6,High,1
P21453,Sphingosine 1-phosphate receptor 1 OS=Homo sapiens OX=9606 GN=S1PR1 PE=1 SV=2,0.005,4.947,2,1,9,1,382,42.8,9.5,4091,,1,,cell differentiation;cell organization and biogenesis;cellular component movement;cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus,endosome;membrane,catalytic activity;protein binding;receptor activity;signal transducer activity,Pf00001,1901,ENSG00000170989.8,S1PR1,1,Neuroactive ligand-receptor interaction; Sphingolipid signaling pathway; FoxO signaling pathway,"GPCRs, Other; Small Ligand GPCRs; Signal Transduction of S1P Receptor",Interleukin-4 and 13 signaling; Lysosphingolipid and LPA receptors; G alpha (i) signalling events,17,High,1
Q5T1R4,Transcription factor HIVEP3 OS=Homo sapiens OX=9606 GN=HIVEP3 PE=2 SV=1,0.005,4.945,1,2,6,1,2406,259.3,7.81,1930,,2,,cell differentiation;development;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,DNA binding;metal ion binding,"Pf00096, Pf13465, Pf13912",59269,ENSG00000127124.14,HIVEP3,1,,,Regulation of RUNX2 expression and activity,5,High,1
Q8NBP0,Tetratricopeptide repeat protein 13 OS=Homo sapiens OX=9606 GN=TTC13 PE=2 SV=3,0.005,4.943,2,1,4,1,860,96.8,7.01,1165,,1,,,,protein binding,"Pf00515, Pf07719, Pf13181, Pf13414, Pf13424, Pf13432, Pf14559",79573,ENSG00000143643.12,TTC13,1,,,,0,High,1
A1XBS5,Protein FAM92A OS=Homo sapiens OX=9606 GN=FAM92A PE=1 SV=2,0.005,4.939,4,1,2,1,289,33.4,6.21,695,,1,,cell organization and biogenesis,cytoplasm;cytoskeleton;nucleus,protein binding,Pf06730,137392,ENSG00000188343.12,FAM92A1; FAM92A,8,,,,0,High,1
Q8TDD1,ATP-dependent RNA helicase DDX54 OS=Homo sapiens OX=9606 GN=DDX54 PE=1 SV=2,0.005,4.938,2,2,35,2,881,98.5,10.02,13371,,2,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;Golgi;membrane;nucleus,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00270, Pf00271, Pf08147",79039,ENSG00000123064.12,DDX54,12,,,,0,High,1
Q9H0E3,Histone deacetylase complex subunit SAP130 OS=Homo sapiens OX=9606 GN=SAP130 PE=1 SV=1,0.005,4.937,1,1,2,1,1048,110.3,9.83,886,,1,,metabolic process;regulation of biological process,nucleus,,,79595,ENSG00000136715.17,SAP130,2,,,HATs acetylate histones; NoRC negatively regulates rRNA expression,7,High,1
P49913,Cathelicidin antimicrobial peptide OS=Homo sapiens OX=9606 GN=CAMP PE=1 SV=1,0.005,4.934,5,1,7,1,170,19.3,9.41,2790,,1,,defense response;regulation of biological process;response to stimulus;transport,extracellular;organelle lumen,protein binding,"Pf00666, Pf12153",820,,CAMP,3,Salivary secretion; NOD-like receptor signaling pathway; Tuberculosis,Sterol Regulatory Element-Binding Proteins (SREBP) signalling,Antimicrobial peptides; Neutrophil degranulation,8,High,1
P08842,Steryl-sulfatase OS=Homo sapiens OX=9606 GN=STS PE=1 SV=2,0.005,4.927,4,2,3,2,583,65.5,7.66,888,,2,,metabolic process,endoplasmic reticulum;endosome;Golgi;membrane;organelle lumen;vacuole,catalytic activity;metal ion binding,"Pf00884, Pf01663, Pf14707",412,ENSG00000101846.6,STS,X,Steroid hormone biosynthesis,Estrogen metabolism,The activation of arylsulfatases; Glycosphingolipid metabolism,10,High,1
Q6ZMK1,Cysteine and histidine-rich protein 1 OS=Homo sapiens OX=9606 GN=CYHR1 PE=1 SV=2,0.005,4.918,4,2,14,2,362,40.7,7.23,4736,,2,,,cytoplasm,metal ion binding;protein binding,,50626,ENSG00000187954.12,CYHR1,8,,,,0,High,1
Q9BV68,E3 ubiquitin-protein ligase RNF126 OS=Homo sapiens OX=9606 GN=RNF126 PE=1 SV=2,0.005,4.914,3,1,5,1,311,33.8,5.47,1845,,1,,,,,,,,,,,,,0,High,1
Q5T5U3,Rho GTPase-activating protein 21 OS=Homo sapiens OX=9606 GN=ARHGAP21 PE=1 SV=2,0.005,4.913,1,1,5,1,1958,217.3,7.8,2298,,1,,,,,,,,,,,,,0,High,1
Q8WVQ1,Soluble calcium-activated nucleotidase 1 OS=Homo sapiens OX=9606 GN=CANT1 PE=1 SV=1,0.005,4.912,1,1,3,1,401,44.8,6.09,1579,,1,,metabolic process;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;extracellular;Golgi;membrane;organelle lumen,catalytic activity;metal ion binding;protein binding;signal transducer activity,Pf06079,124583,ENSG00000171302.16,CANT1,17,Purine metabolism; Pyrimidine metabolism,,Neutrophil degranulation,5,High,1
O15321,Transmembrane 9 superfamily member 1 OS=Homo sapiens OX=9606 GN=TM9SF1 PE=2 SV=2,0.005,4.911,2,1,3,1,606,68.8,7.17,1399,,1,,metabolic process,membrane;vacuole,,Pf02990,10548,ENSG00000100926.14,TM9SF1,14,,,,0,High,1
Q8N612,FTS and Hook-interacting protein OS=Homo sapiens OX=9606 GN=FAM160A2 PE=1 SV=3,0.005,4.91,3,2,2,2,972,105.5,6.77,691,,2,,cell organization and biogenesis;transport,cytosol,protein binding,Pf10257,84067,ENSG00000051009.10,FAM160A2,11,,,,0,High,1
Q3SYC2,2-acylglycerol O-acyltransferase 2 OS=Homo sapiens OX=9606 GN=MOGAT2 PE=1 SV=2,0.005,4.908,4,1,47,1,334,38.2,9.39,13763,,1,,metabolic process;transport,endoplasmic reticulum;membrane,catalytic activity,Pf03982,80168,ENSG00000166391.14,MOGAT2,11,Fat digestion and absorption; Glycerolipid metabolism,Triacylglyceride Synthesis,Triglyceride biosynthesis,7,High,1
L0R8F8,MIEF1 upstream open reading frame protein OS=Homo sapiens OX=9606 GN=MIEF1 PE=1 SV=1,0.005,4.908,11,1,4,1,70,8.4,10.58,1255,,1,,cell organization and biogenesis;regulation of biological process,membrane;mitochondrion,nucleotide binding;protein binding,"Pf05347, Pf13232",54471,ENSG00000100335.13,SMCR7L; MIEF1,22,,,,0,High,1
Q6QNY0,Biogenesis of lysosome-related organelles complex 1 subunit 3 OS=Homo sapiens OX=9606 GN=BLOC1S3 PE=1 SV=1,0.005,4.908,8,1,8,1,202,21.2,5.15,2019,,1,,cell organization and biogenesis;cellular component movement;transport,cytoplasm;cytosol,protein binding,,388552,ENSG00000189114.6,BLOC1S3,19,,,Golgi Associated Vesicle Biogenesis,5,High,1
Q8WY22,BRI3-binding protein OS=Homo sapiens OX=9606 GN=BRI3BP PE=1 SV=1,0.005,4.908,7,1,1,1,251,27.8,9.44,617,,1,,,membrane;mitochondrion,,Pf14965,140707,ENSG00000184992.10,BRI3BP,12,,,,0,High,1
Q9H2F3,3 beta-hydroxysteroid dehydrogenase type 7 OS=Homo sapiens OX=9606 GN=HSD3B7 PE=1 SV=2,0.005,4.903,12,2,8,2,369,41,8.25,1218,,2,,cellular component movement;metabolic process;response to stimulus,endoplasmic reticulum;membrane,catalytic activity;protein binding,"Pf00106, Pf01073, Pf01370, Pf07993, Pf13460",80270,ENSG00000099377.13,HSD3B7,16,Metabolic pathways; Primary bile acid biosynthesis,,Synthesis of bile acids and bile salts via 27-hydroxycholesterol; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Synthesis of bile acids and bile salts via 24-hydroxycholesterol,10,High,1
Q9HCE0,Ectopic P granules protein 5 homolog OS=Homo sapiens OX=9606 GN=EPG5 PE=1 SV=2,0.005,4.901,1,2,5,2,2579,292.3,6.43,1169,,2,,cell organization and biogenesis;metabolic process;transport,cytoplasm,,,57724,ENSG00000152223.12,EPG5,18,,,,0,High,1
Q969Y2,"tRNA modification GTPase GTPBP3, mitochondrial OS=Homo sapiens OX=9606 GN=GTPBP3 PE=1 SV=2",0.005,4.9,4,1,1,1,492,52,6.48,479,,1,,metabolic process;regulation of biological process;response to stimulus,mitochondrion;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00350, Pf00625, Pf01926, Pf02421, Pf08477, Pf10396, Pf12631, Pf13521",84705,ENSG00000130299.16,GTPBP3,19,,,tRNA modification in the mitochondrion,3,High,1
Q9UN66,Protocadherin beta-8 OS=Homo sapiens OX=9606 GN=PCDHB8 PE=2 SV=3,0.005,4.894,4,2,4,2,801,87.6,4.88,936,,2,,cell communication;cell organization and biogenesis,membrane,metal ion binding;protein binding,"Pf00028, Pf08266",56128,,PCDHB8,5,,,,0,High,1
Q9H765,Ankyrin repeat and SOCS box protein 8 OS=Homo sapiens OX=9606 GN=ASB8 PE=2 SV=1,0.005,4.892,4,1,5,1,288,31.6,5.83,2115,,1,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,protein binding,"Pf00023, Pf07525, Pf12796, Pf13606, Pf13637, Pf13857",140461,ENSG00000177981.10,ASB8,12,,,Antigen processing: Ubiquitination & Proteasome degradation; Neddylation,7,High,1
O95528,"Solute carrier family 2, facilitated glucose transporter member 10 OS=Homo sapiens OX=9606 GN=SLC2A10 PE=1 SV=2",0.005,4.882,1,1,2,1,541,56.9,8.59,1037,,1,,transport,cytoplasm;cytosol;membrane,transporter activity,"Pf00083, Pf07690",81031,ENSG00000197496.5,SLC2A10,20,,NRF2 pathway,Defective SLC2A10 causes arterial tortuosity syndrome (ATS); Cellular hexose transport,8,High,1
Q6XUX3,Dual serine/threonine and tyrosine protein kinase OS=Homo sapiens OX=9606 GN=DSTYK PE=1 SV=2,0.005,4.879,2,2,3,2,929,105.1,6.74,848,,2,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;nucleotide binding,"Pf00069, Pf07714, Pf14531",25778,ENSG00000133059.16,DSTYK,1,,,,0,High,1
Q6ZMM2,ADAMTS-like protein 5 OS=Homo sapiens OX=9606 GN=ADAMTSL5 PE=1 SV=3,0.005,4.873,2,1,14,1,481,53.2,8.19,4429,,1,,metabolic process,extracellular,catalytic activity;metal ion binding;protein binding,"Pf01759, Pf05986",339366,,ADAMTSL5,19,,,O-glycosylation of TSR domain-containing proteins; Defective B3GALTL causes Peters-plus syndrome (PpS),8,High,1
Q7L273,BTB/POZ domain-containing protein KCTD9 OS=Homo sapiens OX=9606 GN=KCTD9 PE=1 SV=1,0.005,4.864,5,1,3,1,389,42.5,6.37,701,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,,protein binding,"Pf00651, Pf00805, Pf02214, Pf11834, Pf13599",54793,ENSG00000104756.15,KCTD9,8,,,,0,High,1
Q5TD97,Four and a half LIM domains protein 5 OS=Homo sapiens OX=9606 GN=FHL5 PE=1 SV=1,0.005,4.863,6,2,13,2,284,32.7,7.52,5120,,2,,regulation of biological process,nucleus,metal ion binding;protein binding,Pf00412,9457,ENSG00000112214.10,FHL5,6,,,,0,High,1
Q7Z7L8,Uncharacterized protein C11orf96 OS=Homo sapiens OX=9606 GN=C11orf96 PE=1 SV=3,0.005,4.86,2,1,4,1,435,46.1,9.99,1695,,1,,,,,,387763,ENSG00000187479.5,C11orf96,11,,,,0,High,1
P60673,Profilin-3 OS=Homo sapiens OX=9606 GN=PFN3 PE=2 SV=1,0.005,4.856,12,2,2,2,137,14.6,9.26,854,,2,,cell organization and biogenesis;regulation of biological process,cytoplasm;cytoskeleton;nucleus,protein binding,Pf00235,345456,ENSG00000196570.2,PFN3,5,Salmonella infection; Regulation of actin cytoskeleton; Rap1 signaling pathway; Shigellosis,Association Between Physico-Chemical Features and Toxicity Associated Pathways,,5,High,1
P32780,General transcription factor IIH subunit 1 OS=Homo sapiens OX=9606 GN=GTF2H1 PE=1 SV=1,0.005,4.851,5,2,4,2,548,62,8.66,757,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,nucleus,catalytic activity;protein binding,"Pf03909, Pf08567",2965,ENSG00000110768.11,GTF2H1,11,Basal transcription factors; Nucleotide excision repair; Viral carcinogenesis,Eukaryotic Transcription Initiation,Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase I Chain Elongation; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; NoRC negatively regulates rRNA expression; Formation of TC-NER Pre-Incision Complex; Dual Incision in GG-NER; RNA Polymerase I Promoter Escape; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Promoter Escape; RNA Pol II CTD phosphorylation and interaction with CE; Formation of the HIV-1 Early Elongation Complex; Formation of Incision Complex in GG-NER; RNA Polymerase I Transcription Termination; RNA Polymerase II Transcription Initiation; mRNA Capping; TP53 Regulates Transcription of DNA Repair Genes; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Dual incision in TC-NER; Formation of RNA Pol II elongation complex ; RNA Polymerase II HIV Promoter Escape; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase II Pre-transcription Events; RNA Polymerase I Transcription Initiation; Formation of the Early Elongation Complex,52,High,1
Q5PRF9,Protein Smaug homolog 2 OS=Homo sapiens OX=9606 GN=SAMD4B PE=1 SV=1,0.005,4.849,5,2,3,2,694,75.4,6.83,699,,2,,metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,protein binding;RNA binding;translation regulator activity,"Pf00536, Pf07647",55095,ENSG00000179134.15,SAMD4B,19,,,,0,High,1
Q14114,Low-density lipoprotein receptor-related protein 8 OS=Homo sapiens OX=9606 GN=LRP8 PE=1 SV=4,0.005,4.844,1,1,31,1,963,105.6,5.05,13796,,1,,metabolic process;regulation of biological process;response to stimulus;transport,cell surface;extracellular;membrane,metal ion binding;protein binding;receptor activity;signal transducer activity,"Pf00057, Pf00058, Pf06247, Pf07645, Pf08450, Pf12662, Pf14670",7804,ENSG00000157193.15,LRP8,1,,,Signaling by GPCR; Retinoid metabolism and transport; Platelet sensitization by LDL,10,High,1
O95503,Chromobox protein homolog 6 OS=Homo sapiens OX=9606 GN=CBX6 PE=1 SV=1,0.005,4.838,2,1,2,1,412,43.9,10.01,866,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,chromosome;nucleus,protein binding;RNA binding,Pf00385,23466,ENSG00000183741.11,CBX6,22,,,RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN gene transcription; Oxidative Stress Induced Senescence,14,High,1
O15056,Synaptojanin-2 OS=Homo sapiens OX=9606 GN=SYNJ2 PE=1 SV=3,0.005,4.827,1,2,2,2,1496,165.4,7.34,813,,2,,cell organization and biogenesis;metabolic process,cytoplasm;cytoskeleton;cytosol;membrane,catalytic activity;protein binding;RNA binding,"Pf02383, Pf03372, Pf08952",8871,ENSG00000078269.14,SYNJ2,6,Metabolic pathways; Phosphatidylinositol signaling system; Inositol phosphate metabolism,,Synthesis of PIPs at the plasma membrane; Clathrin-mediated endocytosis,11,High,1
Q9Y5Q9,General transcription factor 3C polypeptide 3 OS=Homo sapiens OX=9606 GN=GTF3C3 PE=1 SV=1,0.005,4.82,1,1,1,1,886,101.2,5.07,412,,1,,metabolic process;regulation of biological process,membrane;nucleus,DNA binding;protein binding,"Pf13414, Pf13424, Pf13432",9330,ENSG00000119041.10,GTF3C3,2,,,RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter,6,High,1
Q8N3I7,Bardet-Biedl syndrome 5 protein OS=Homo sapiens OX=9606 GN=BBS5 PE=1 SV=1,0.005,4.818,3,1,1,1,341,38.7,5.6,548,,1,,cell organization and biogenesis;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane,protein binding,Pf07289,129880,ENSG00000163093.11,BBS5,2,,,BBSome-mediated cargo-targeting to cilium,4,High,1
Q86WJ1,Chromodomain-helicase-DNA-binding protein 1-like OS=Homo sapiens OX=9606 GN=CHD1L PE=1 SV=3,0.005,4.817,2,2,4,2,897,100.9,6.9,868,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00176, Pf00270, Pf00271, Pf11496",9557,ENSG00000131778.18,CHD1L; LOC101060601,1,,,,0,High,1
Q5TCZ1,SH3 and PX domain-containing protein 2A OS=Homo sapiens OX=9606 GN=SH3PXD2A PE=1 SV=1,0.005,4.81,1,1,1,1,1133,125.2,8.9,236,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol,enzyme regulator activity;protein binding,"Pf00018, Pf00787, Pf07653, Pf08239, Pf14604",9644,ENSG00000107957.16,SH3PXD2A,10,,,Invadopodia formation,2,High,1
Q9Y2H2,Phosphatidylinositide phosphatase SAC2 OS=Homo sapiens OX=9606 GN=INPP5F PE=1 SV=3,0.005,4.797,1,2,6,2,1132,128.3,7.02,2018,,2,,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;endosome;membrane,catalytic activity;protein binding,"Pf02383, Pf12456",22876,ENSG00000198825.12,INPP5F,10,,,Synthesis of PIPs at the early endosome membrane,5,High,1
P01833,Polymeric immunoglobulin receptor OS=Homo sapiens OX=9606 GN=PIGR PE=1 SV=4,0.005,4.782,2,2,23,2,764,83.2,5.74,10246,,2,,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,extracellular;membrane,receptor activity;signal transducer activity,,5284,ENSG00000162896.5,PIGR,1,Intestinal immune network for IgA production,,Neutrophil degranulation,4,High,1
O95980,Reversion-inducing cysteine-rich protein with Kazal motifs OS=Homo sapiens OX=9606 GN=RECK PE=1 SV=1,0.005,4.78,1,1,6,1,971,106.4,6.74,2566,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,extracellular;membrane,enzyme regulator activity;protein binding,"Pf07648, Pf14828",8434,ENSG00000122707.11,RECK,9,MicroRNAs in cancer,,Post-translational modification: synthesis of GPI-anchored proteins,4,High,1
O94985,Calsyntenin-1 OS=Homo sapiens OX=9606 GN=CLSTN1 PE=1 SV=1,0.005,4.775,1,1,2,1,981,109.7,4.91,694,,1,,regulation of biological process,cell surface;endoplasmic reticulum;extracellular;Golgi;membrane;nucleus,metal ion binding;protein binding,"Pf00028, Pf02210, Pf13385",22883,ENSG00000171603.16,CLSTN1,1,,,,0,High,1
Q08830,Fibrinogen-like protein 1 OS=Homo sapiens OX=9606 GN=FGL1 PE=1 SV=3,0.005,4.759,3,1,3,1,312,36.4,5.87,1757,,1,,,extracellular,,Pf00147,2267,ENSG00000104760.16,FGL1,8,,,,0,High,1
Q9NQ79,Cartilage acidic protein 1 OS=Homo sapiens OX=9606 GN=CRTAC1 PE=1 SV=2,0.005,4.758,3,2,3,2,661,71.4,5.12,855,,2,,,extracellular,metal ion binding;protein binding,"Pf01839, Pf07593, Pf07645, Pf13517",55118,ENSG00000095713.13,CRTAC1,10,,,,0,High,1
Q6P5Z2,Serine/threonine-protein kinase N3 OS=Homo sapiens OX=9606 GN=PKN3 PE=1 SV=1,0.005,4.757,2,2,3,2,889,99.4,8.46,807,,2,,cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;Golgi;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf02185, Pf07714, Pf14531",29941,ENSG00000160447.6,PKN3,9,Salmonella infection; PI3K-Akt signaling pathway,,RHO GTPases activate PKNs,6,High,1
P28332,Alcohol dehydrogenase 6 OS=Homo sapiens OX=9606 GN=ADH6 PE=1 SV=3,0.005,4.746,3,2,16,2,368,39,7.8,5785,,2,,metabolic process;response to stimulus,cytosol,catalytic activity;metal ion binding,"Pf00107, Pf08240",130,ENSG00000172955.17,ADH6,4,Tyrosine metabolism; Glycolysis / Gluconeogenesis; Metabolism of xenobiotics by cytochrome P450; Metabolic pathways; Retinol metabolism; Drug metabolism - cytochrome P450; Fatty acid degradation; Chemical carcinogenesis,Fatty Acid Omega Oxidation,,9,High,1
Q460N5-1,Isoform 1 of Protein mono-ADP-ribosyltransferase PARP14 OS=Homo sapiens OX=9606 GN=PARP14,0.005,4.744,1,1,2,1,1720,193.6,7.97,598,,1,,metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;nucleus,catalytic activity;protein binding;RNA binding,"Pf00644, Pf01661",54625,,PARP14,3,,,,0,High,1
P35226,Polycomb complex protein BMI-1 OS=Homo sapiens OX=9606 GN=BMI1 PE=1 SV=2,0.005,4.737,2,1,3,1,326,36.9,8.63,1690,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,metal ion binding;protein binding,"Pf00097, Pf12678, Pf13639, Pf13920, Pf13923, Pf15227",648; 100532731,ENSG00000168283.13,BMI1; COMMD3-BMI1,10,MicroRNAs in cancer; Signaling pathways regulating pluripotency of stem cells; Transcriptional misregulation in cancer,Senescence and Autophagy in Cancer,RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; SUMOylation of chromatin organization proteins; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; SUMOylation of DNA damage response and repair proteins; Oxidative Stress Induced Senescence; SUMOylation of RNA binding proteins,26,High,1
Q13563,Polycystin-2 OS=Homo sapiens OX=9606 GN=PKD2 PE=1 SV=3,0.005,4.736,1,1,1,1,968,109.6,5.69,495,,1,,cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;membrane,metal ion binding;protein binding;transporter activity,"Pf00520, Pf08016",5311,ENSG00000118762.7,PKD2,4,,,VxPx cargo-targeting to cilium,4,High,1
Q9H3U5,Major facilitator superfamily domain-containing protein 1 OS=Homo sapiens OX=9606 GN=MFSD1 PE=2 SV=2,0.005,4.734,3,1,4,1,465,51.2,6.74,2010,,1,,transport,membrane,,"Pf07690, Pf13347",64747,ENSG00000118855.18,MFSD1,3,,,,0,High,1
Q8NC54,Keratinocyte-associated transmembrane protein 2 OS=Homo sapiens OX=9606 GN=KCT2 PE=1 SV=2,0.005,4.732,3,1,4,1,265,29.2,5.08,2286,,1,,,membrane,,,56951,ENSG00000113583.7,C5orf15,5,,,,0,High,1
A1KZ92,Peroxidasin-like protein OS=Homo sapiens OX=9606 GN=PXDNL PE=1 SV=3,0.005,4.73,1,1,1,1,1463,163.6,7.43,,0,,1,metabolic process;response to stimulus,cytoplasm;extracellular,antioxidant activity;catalytic activity;metal ion binding;protein binding,"Pf00047, Pf00093, Pf03098, Pf05825, Pf07679, Pf12714, Pf12799, Pf13855, Pf13895, Pf13927",137902,ENSG00000147485.12,PXDNL,8,,,,0,High,1
Q8N9N8,Probable RNA-binding protein EIF1AD OS=Homo sapiens OX=9606 GN=EIF1AD PE=1 SV=1,0.005,4.727,10,1,4,1,165,19,5.21,934,,1,,metabolic process,nucleus,protein binding;RNA binding,Pf01176,84285,ENSG00000175376.8,EIF1AD,11,,,,0,High,1
P18054,"Arachidonate 12-lipoxygenase, 12S-type OS=Homo sapiens OX=9606 GN=ALOX12 PE=1 SV=4",0.005,4.726,1,1,9,1,663,75.6,6.21,2879,,1,,cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;metal ion binding;protein binding,"Pf00305, Pf01477",239,ENSG00000108839.11,ALOX12,17,Antifolate resistance; Inflammatory mediator regulation of TRP channels; Metabolic pathways; Arachidonic acid metabolism; Serotonergic synapse,Eicosanoid Synthesis,Synthesis of 12-eicosatetraenoic acid derivatives; Synthesis of Hepoxilins (HX) and Trioxilins (TrX); Synthesis of Lipoxins (LX),13,High,1
Q96FN5,Kinesin-like protein KIF12 OS=Homo sapiens OX=9606 GN=KIF12 PE=1 SV=3,0.005,4.725,1,1,16,1,646,70.6,8.85,8253,,1,,cellular component movement,cytoplasm;cytoskeleton,catalytic activity;motor activity;nucleotide binding;protein binding,Pf00225,113220,ENSG00000136883.13,KIF12,9,,,COPI-dependent Golgi-to-ER retrograde traffic; Kinesins,8,High,1
P08183,ATP-dependent translocase ABCB1 OS=Homo sapiens OX=9606 GN=ABCB1 PE=1 SV=3,0.005,4.723,2,2,10,2,1280,141.4,9,3045,,2,,cell organization and biogenesis;cell proliferation;regulation of biological process;response to stimulus;transport,cell surface;membrane,catalytic activity;nucleotide binding;protein binding;transporter activity,"Pf00005, Pf00664, Pf09818, Pf13558",5243,ENSG00000085563.14,ABCB1,7,ABC transporters; MicroRNAs in cancer; Bile secretion,Codeine and Morphine Metabolism; Drug Induction of Bile Acid Pathway; Allograft Rejection; Constitutive Androstane Receptor Pathway; Nuclear Receptors in Lipid Metabolism and Toxicity; Imatinib and Chronic Myeloid Leukemia; LncRNA-mediated mechanisms of therapeutic resistance,Abacavir transmembrane transport; ABC-family proteins mediated transport,15,High,1
P78396,Cyclin-A1 OS=Homo sapiens OX=9606 GN=CCNA1 PE=1 SV=1,0.005,4.722,2,1,12,1,465,52.3,5.1,7638,,1,,cell division;cell organization and biogenesis;metabolic process;regulation of biological process,cytoskeleton;cytosol;nucleus,protein binding,"Pf00134, Pf02984",8900,ENSG00000133101.9,CCNA1,13,Progesterone-mediated oocyte maturation; AMPK signaling pathway; Epstein-Barr virus infection; Viral carcinogenesis; Transcriptional misregulation in cancer; Pathways in cancer; Acute myeloid leukemia; Hepatitis B; Cell cycle,AMP-activated Protein Kinase (AMPK) Signaling; Cell Cycle; Gastric Cancer Network 1; G1 to S cell cycle control,p53-Dependent G1 DNA Damage Response; G0 and Early G1; Regulation of DNA replication; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; SCF(Skp2)-mediated degradation of p27/p21; G2 Phase; Regulation of APC/C activators between G1/S and early anaphase; Activation of E2F1 target genes at G1/S; Regulation of TP53 Activity through Phosphorylation; Ub-specific processing proteases; Regulation of TP53 Degradation; Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes; Orc1 removal from chromatin; Processing of DNA double-strand break ends; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; DNA Damage/Telomere Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Removal of licensing factors from origins,70,High,1
Q9UMY1,Nucleolar protein 7 OS=Homo sapiens OX=9606 GN=NOL7 PE=1 SV=2,0.005,4.714,10,2,5,1,257,29.4,9.67,1306,,2,,,mitochondrion;nucleus,RNA binding,Pf08157,51406,ENSG00000225921.6,NOL7,6,,,,0,High,1
P52655,Transcription initiation factor IIA subunit 1 OS=Homo sapiens OX=9606 GN=GTF2A1 PE=1 SV=1,0.005,4.712,3,1,2,1,376,41.5,4.55,1083,,1,,metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,DNA binding;protein binding,Pf03153,2957,ENSG00000165417.11,GTF2A1,14,Viral carcinogenesis; Basal transcription factors,,RNA polymerase II transcribes snRNA genes; RNA Polymerase II Transcription Initiation; HIV Transcription Initiation; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Pre-transcription Events; RNA Polymerase II Promoter Escape,18,High,1
Q8NF50,Dedicator of cytokinesis protein 8 OS=Homo sapiens OX=9606 GN=DOCK8 PE=1 SV=3,0.005,4.71,1,2,4,1,2099,238.4,6.87,1090,,2,,cell proliferation;cellular component movement;coagulation;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,protein binding,"Pf06920, Pf11878, Pf14429",81704,ENSG00000107099.15,DOCK8,9,,,Factors involved in megakaryocyte development and platelet production,2,High,1
P0CG12,Decreased expression in renal and prostate cancer protein OS=Homo sapiens OX=9606 GN=DERPC PE=1 SV=1,0.005,4.707,2,1,3,1,524,51.4,12.41,1425,,1,,cell organization and biogenesis,nucleus,,,54921,ENSG00000168802.12,CHTF8,16,,Gastric cancer network 2,,1,High,1
A1X283,SH3 and PX domain-containing protein 2B OS=Homo sapiens OX=9606 GN=SH3PXD2B PE=1 SV=3,0.005,4.704,2,2,2,2,911,101.5,8.69,705,,2,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm,enzyme regulator activity;protein binding,"Pf00018, Pf00787, Pf06347, Pf07653, Pf08239, Pf14604",285590,ENSG00000174705.12,SH3PXD2B,5,,,,0,High,1
Q12774,Rho guanine nucleotide exchange factor 5 OS=Homo sapiens OX=9606 GN=ARHGEF5 PE=1 SV=3,0.006,4.688,1,1,19,1,1597,176.7,5.53,7521,,1,,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,nucleotide binding;protein binding,"Pf00018, Pf00169, Pf00621, Pf07653, Pf14604, Pf15441",7984,ENSG00000050327.14,ARHGEF5,7,,,G alpha (12/13) signalling events; NRAGE signals death through JNK; Signalling by NGF; Rho GTPase cycle,11,High,1
Q12824,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 OS=Homo sapiens OX=9606 GN=SMARCB1 PE=1 SV=2,0.006,4.687,2,1,3,1,385,44.1,6.23,1415,,1,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;nucleus,DNA binding;protein binding,Pf04855,6598,ENSG00000099956.18; ENSG00000275837.3,SMARCB1,22; CHR_HSCHR22_1_CTG7,,,RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines,8,High,1
Q9H4I9,"Essential MCU regulator, mitochondrial OS=Homo sapiens OX=9606 GN=SMDT1 PE=1 SV=1",0.006,4.686,7,1,4,1,107,11.4,7.27,2205,,1,,cellular homeostasis;transport,membrane;mitochondrion;nucleus;organelle lumen,protein binding,Pf10161,91689,ENSG00000272901.5; ENSG00000272835.3; ENSG00000183172.8; ENSG00000274112.2,C22orf32; SMDT1,22; CHR_HSCHR22_1_CTG1; CHR_HSCHR22_2_CTG1; CHR_HSCHR22_3_CTG1,,,Processing of SMDT1,3,High,1
Q15842,ATP-sensitive inward rectifier potassium channel 8 OS=Homo sapiens OX=9606 GN=KCNJ8 PE=1 SV=1,0.006,4.681,6,2,3,2,424,47.9,9.26,289,2.18,1,1,defense response;regulation of biological process;response to stimulus;transport,membrane;mitochondrion,nucleotide binding;protein binding;transporter activity,Pf01007,3764,ENSG00000121361.3,KCNJ8,12,cGMP-PKG signaling pathway,Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,ATP sensitive Potassium channels,6,High,1
Q6FIF0,AN1-type zinc finger protein 6 OS=Homo sapiens OX=9606 GN=ZFAND6 PE=1 SV=2,0.006,4.673,4,1,1,1,208,22.5,7.2,622,,1,,cell death;cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm,DNA binding;metal ion binding;protein binding,"Pf01428, Pf01754",54469,ENSG00000086666.18,ZFAND6,15,,,,0,High,1
P52564,Dual specificity mitogen-activated protein kinase kinase 6 OS=Homo sapiens OX=9606 GN=MAP2K6 PE=1 SV=1,0.006,4.664,4,1,2,1,334,37.5,7.39,1060,,1,,cell death;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf07714, Pf14531",5608,ENSG00000108984.13,MAP2K6,17,Epstein-Barr virus infection; GnRH signaling pathway; Fc epsilon RI signaling pathway; MAPK signaling pathway; Osteoclast differentiation; Influenza A; Inflammatory mediator regulation of TRP channels; Toxoplasmosis; Amyotrophic lateral sclerosis (ALS); Toll-like receptor signaling pathway; Rap1 signaling pathway; TNF signaling pathway,"Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated Cell Adhesion; IL-1 signaling pathway; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; Human Thyroid Stimulating Hormone (TSH) signaling pathway; Signaling Pathways in Glioblastoma; B Cell Receptor Signaling Pathway; TNF alpha Signaling Pathway; Amyotrophic lateral sclerosis (ALS); Structural Pathway of Interleukin 1 (IL-1); Cardiac Hypertrophic Response; Focal Adhesion; TGF-beta Signaling Pathway; MAPK Signaling Pathway; 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; ESC Pluripotency Pathways; p38 MAPK Signaling Pathway; MAPK Cascade; Insulin Signaling; Interferon type I signaling pathways; Toll-like receptor signaling pathway",PI5P Regulates TP53 Acetylation; NOD1/2 Signaling Pathway; Uptake and function of anthrax toxins; Activated TLR4 signalling; Interleukin-1 family signaling; CDO in myogenesis; activated TAK1 mediates p38 MAPK activation; Oxidative Stress Induced Senescence,81,High,1
Q9UKI2,Cdc42 effector protein 3 OS=Homo sapiens OX=9606 GN=CDC42EP3 PE=1 SV=1,0.006,4.661,6,1,2,1,254,27.7,5.78,654,,1,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane,enzyme regulator activity;protein binding,"Pf00786, Pf14957",10602,ENSG00000163171.7,CDC42EP3,2,,,MAPK6/MAPK4 signaling,3,High,1
Q86YV5,Inactive tyrosine-protein kinase PRAG1 OS=Homo sapiens OX=9606 GN=PRAG1 PE=1 SV=4,0.006,4.659,1,2,7,2,1406,149.5,7.2,2955,,2,,metabolic process,,catalytic activity;nucleotide binding,"Pf00069, Pf07714",157285,ENSG00000275342.4,SGK223; PRAG1,8,,,,0,High,1
Q9NUJ3,T-complex protein 11-like protein 1 OS=Homo sapiens OX=9606 GN=TCP11L1 PE=1 SV=1,0.006,4.64,3,2,6,2,509,57,5.59,1874,,2,,,,,Pf05794,55346,ENSG00000176148.15,TCP11L1,11,,,,0,High,1
Q14692,Ribosome biogenesis protein BMS1 homolog OS=Homo sapiens OX=9606 GN=BMS1 PE=1 SV=1,0.006,4.613,2,2,9,2,1282,145.7,6.44,2588,,2,,cell organization and biogenesis;metabolic process,nucleus,catalytic activity;nucleotide binding;RNA binding,"Pf04950, Pf08142",9790,ENSG00000165733.7,BMS1,10,Ribosome biogenesis in eukaryotes,,Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol,6,High,1
O94823,Probable phospholipid-transporting ATPase VB OS=Homo sapiens OX=9606 GN=ATP10B PE=2 SV=2,0.006,4.612,0,1,61,1,1461,165.3,6.89,25173,,1,,cell organization and biogenesis;transport,endoplasmic reticulum;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding;transporter activity,"Pf00122, Pf00702, Pf08282, Pf13246",23120,ENSG00000118322.12,ATP10B,5,,,Ion transport by P-type ATPases,3,High,1
Q9HDB5,Neurexin-3-beta OS=Homo sapiens OX=9606 GN=NRXN3 PE=1 SV=4,0.006,4.608,3,2,9,1,637,69.3,7.21,2291,,2,,cell communication;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport,membrane,metal ion binding;protein binding;receptor activity;signal transducer activity,"Pf00054, Pf02210",9369,ENSG00000021645.18,NRXN3,14,Cell adhesion molecules (CAMs),,Neurexins and neuroligins,4,High,1
Q8N138,ORM1-like protein 3 OS=Homo sapiens OX=9606 GN=ORMDL3 PE=1 SV=1,0.006,4.604,12,2,2,1,153,17.5,9.64,521,,2,,cellular homeostasis;metabolic process;regulation of biological process;transport,endoplasmic reticulum;membrane,protein binding,Pf04061,94103,ENSG00000172057.9,ORMDL3,17,,,Neutrophil degranulation; Sphingolipid de novo biosynthesis,7,High,1
Q9ULR3,Protein phosphatase 1H OS=Homo sapiens OX=9606 GN=PPM1H PE=1 SV=2,0.006,4.601,5,2,3,1,514,56.4,6.6,690,,2,,metabolic process,cytoplasm;nucleus,catalytic activity,Pf00481,57460,ENSG00000111110.11,PPM1H,12,,,,0,High,1
Q9HAU6,Putative translationally-controlled tumor protein-like protein TPT1P8 OS=Homo sapiens OX=9606 GN=TPT1P8 PE=5 SV=2,0.006,4.599,10,1,4,1,139,16,5.58,1060,,1,,cell death;cell differentiation,cytoplasm,metal ion binding;protein binding,Pf00838,59347,,FKSG2; TPT1P8,8,,,,0,High,1
Q8NB46,Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C OS=Homo sapiens OX=9606 GN=ANKRD52 PE=1 SV=3,0.006,4.593,1,1,2,1,1076,115,6.48,464,,1,,,,protein binding,"Pf00023, Pf12796, Pf13606, Pf13637, Pf13857",283373,ENSG00000139645.9,ANKRD52,12,,,,0,High,1
A0A075B6I4,Immunoglobulin lambda variable 10-54 OS=Homo sapiens OX=9606 GN=IGLV10-54 PE=3 SV=1,0.006,4.589,9,1,15,1,117,12.4,8.03,5920,,1,,response to stimulus,extracellular;membrane,,"Pf07679, Pf07686",28772,ENSG00000211642.3,IGLV10-54,22,,,,0,High,1
Q309B1,Tripartite motif-containing protein 16-like protein OS=Homo sapiens OX=9606 GN=TRIM16L PE=2 SV=3,0.006,4.585,10,2,13,1,348,40.3,6.2,3868,,2,,,cytoplasm;cytosol;membrane,protein binding,"Pf00622, Pf13765",147166,ENSG00000108448.20,TRIM16L,17,,,,0,High,1
Q9Y6H8,Gap junction alpha-3 protein OS=Homo sapiens OX=9606 GN=GJA3 PE=1 SV=4,0.006,4.582,2,1,5,1,435,47.4,6.61,2467,,1,,cell communication;transport,membrane,transporter activity,"Pf00029, Pf10582",2700,ENSG00000121743.3,GJA3,13,,Calcium Regulation in the Cardiac Cell,Gap junction assembly,6,High,1
Q9H2S1,Small conductance calcium-activated potassium channel protein 2 OS=Homo sapiens OX=9606 GN=KCNN2 PE=1 SV=2,0.006,4.579,2,1,8,1,579,63.7,9.52,3516,,1,,metabolic process;regulation of biological process;transport,cell surface;membrane,protein binding;transporter activity,"Pf01920, Pf02888, Pf03530, Pf07885",3781,ENSG00000080709.14,KCNN2,5,Insulin secretion; Serotonergic synapse; Bile secretion,Brain-Derived Neurotrophic Factor (BDNF) signaling pathway,Ca2+ activated K+ channels,7,High,1
Q9C0C7,Activating molecule in BECN1-regulated autophagy protein 1 OS=Homo sapiens OX=9606 GN=AMBRA1 PE=1 SV=2,0.006,4.569,2,2,3,2,1298,142.4,7.18,1118,,2,,cell communication;cell differentiation;cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;mitochondrion;vacuole,protein binding,Pf00400,55626,ENSG00000110497.14,AMBRA1,11,,Nanoparticle triggered autophagic cell death; Senescence and Autophagy in Cancer,Macroautophagy,4,High,1
Q6ZU15,Septin-14 OS=Homo sapiens OX=9606 GN=SEPTIN14 PE=1 SV=2,0.006,4.567,5,2,13,2,432,50,6.24,3798,,2,,cell division,cytoplasm;cytoskeleton,nucleotide binding;protein binding,"Pf00735, Pf13191",346288,ENSG00000154997.8,SEPT14,7,,,,0,High,1
Q9BRP1,Programmed cell death protein 2-like OS=Homo sapiens OX=9606 GN=PDCD2L PE=1 SV=1,0.006,4.566,3,1,13,1,358,39.4,4.86,6139,,1,,,cytoplasm;membrane,,Pf04194,84306,ENSG00000126249.7,PDCD2L,19,,,,0,High,1
Q9Y2W6,Tudor and KH domain-containing protein OS=Homo sapiens OX=9606 GN=TDRKH PE=1 SV=2,0.006,4.559,2,1,3,1,561,62,5.02,1375,,1,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;mitochondrion,RNA binding,"Pf00013, Pf00567, Pf07650, Pf13014",11022,ENSG00000182134.15,TDRKH,1,,,PIWI-interacting RNA (piRNA) biogenesis,3,High,1
P54851,Epithelial membrane protein 2 OS=Homo sapiens OX=9606 GN=EMP2 PE=1 SV=1,0.006,4.55,4,1,34,1,167,19.2,7.62,12940,,1,,cell death;cell organization and biogenesis;cell proliferation;cellular component movement;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;cytosol;Golgi;membrane;nucleus,protein binding,"Pf00822, Pf13903",2013,ENSG00000213853.9,EMP2,16,,,,0,High,1
Q7Z695,Uncharacterized aarF domain-containing protein kinase 2 OS=Homo sapiens OX=9606 GN=ADCK2 PE=1 SV=1,0.006,4.548,1,1,11,1,626,68.9,8.76,4492,,1,,metabolic process,membrane,catalytic activity;enzyme regulator activity;nucleotide binding;receptor activity;signal transducer activity,Pf03109,90956,ENSG00000133597.10,ADCK2,7,,,,0,High,1
O95476,CTD nuclear envelope phosphatase 1 OS=Homo sapiens OX=9606 GN=CTDNEP1 PE=1 SV=2,0.006,4.548,9,1,2,1,244,28.4,9.76,753,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;endoplasmic reticulum;membrane;nucleus,catalytic activity;protein binding,Pf03031,23399,ENSG00000175826.11,CTDNEP1,17,,,Depolymerisation of the Nuclear Lamina,6,High,1
Q96GS4,BLOC-1-related complex subunit 6 OS=Homo sapiens OX=9606 GN=BORCS6 PE=1 SV=2,0.006,4.545,5,1,4,1,357,37.2,5.76,1292,,1,,,membrane;vacuole,protein binding,Pf10157,54785,ENSG00000196544.7,C17orf59; BORCS6,17,,,,0,High,1
Q9BQ61,Telomerase RNA component interacting RNase OS=Homo sapiens OX=9606 GN=TRIR PE=1 SV=1,0.006,4.531,7,1,3,1,176,18.4,9.44,1159,,1,,,,protein binding,,79002,ENSG00000123144.10,C19orf43; TRIR,19,,,,0,High,1
P54764,Ephrin type-A receptor 4 OS=Homo sapiens OX=9606 GN=EPHA4 PE=1 SV=1,0.006,4.53,1,1,3,1,986,109.8,6.61,1315,,1,,cell organization and biogenesis;cellular component movement;development;metabolic process;regulation of biological process;response to stimulus,cell surface;cytoplasm;endoplasmic reticulum;endosome;Golgi;membrane,catalytic activity;nucleotide binding;protein binding;receptor activity;signal transducer activity,"Pf00041, Pf00069, Pf00536, Pf01404, Pf07647, Pf07699, Pf07714, Pf14575",2043,ENSG00000116106.11,EPHA4,2,Axon guidance,Spinal Cord Injury; Gene regulatory network modelling somitogenesis,EPH-ephrin mediated repulsion of cells; EPHA-mediated growth cone collapse,8,High,1
Q76N32,Centrosomal protein of 68 kDa OS=Homo sapiens OX=9606 GN=CEP68 PE=1 SV=2,0.006,4.529,2,1,3,1,757,81.1,5.16,1078,,1,,cell organization and biogenesis,cytoplasm;cytoskeleton;cytosol;nucleus,protein binding,,23177,ENSG00000011523.13,CEP68,2,,,,0,High,1
Q53H47,Histone-lysine N-methyltransferase SETMAR OS=Homo sapiens OX=9606 GN=SETMAR PE=1 SV=2,0.006,4.523,6,2,6,2,684,78,7.14,1408,,2,,cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus,chromosome;nucleus,catalytic activity;DNA binding;metal ion binding;protein binding,"Pf00856, Pf01359, Pf01498, Pf05033, Pf12802, Pf12840, Pf13358, Pf13551, Pf13565",6419,ENSG00000170364.12,SETMAR,3,Lysine degradation,Histone Modifications,,2,High,1
P17213,Bactericidal permeability-increasing protein OS=Homo sapiens OX=9606 GN=BPI PE=1 SV=4,0.006,4.522,4,2,20,2,487,53.9,9.38,4796,,2,,defense response;regulation of biological process;response to stimulus;transport,cytoplasm;extracellular;membrane;organelle lumen,,"Pf01273, Pf02886",671,ENSG00000101425.12,BPI,20,,,Antimicrobial peptides; Neutrophil degranulation; Toll Like Receptor 4 (TLR4) Cascade,6,High,1
Q9Y605,MORF4 family-associated protein 1 OS=Homo sapiens OX=9606 GN=MRFAP1 PE=1 SV=1,0.006,4.516,8,1,1,1,127,14.6,4.7,514,,1,,,cytoplasm;cytosol;nucleus,protein binding,Pf15155,93621,ENSG00000179010.14,MRFAP1,4,,,,0,High,1
Q9H2H9,Sodium-coupled neutral amino acid transporter 1 OS=Homo sapiens OX=9606 GN=SLC38A1 PE=1 SV=1,0.006,4.516,2,1,1,1,487,54,7.02,334,,1,,transport,membrane,protein binding;transporter activity,Pf01490,81539,ENSG00000111371.15,SLC38A1,12,Glutamatergic synapse; GABAergic synapse,Synaptic Vesicle Pathway,Amino acid transport across the plasma membrane; Astrocytic Glutamate-Glutamine Uptake And Metabolism,11,High,1
Q96FX8,p53 apoptosis effector related to PMP-22 OS=Homo sapiens OX=9606 GN=PERP PE=2 SV=1,0.006,4.515,9,1,10,1,193,21.4,7.03,3444,,1,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,Golgi;membrane;mitochondrion,,,64065,ENSG00000112378.11,PERP,6,p53 signaling pathway,,Formation of the cornified envelope; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain,10,High,1
Q9HBF4,Zinc finger FYVE domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ZFYVE1 PE=1 SV=1,0.006,4.513,2,1,5,1,777,87.1,7.42,1355,,1,,cell communication;metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;Golgi;membrane;vacuole,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf01363, Pf02263",53349,ENSG00000165861.13,ZFYVE1,14,,,,0,High,1
Q15735,"Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A OS=Homo sapiens OX=9606 GN=INPP5J PE=1 SV=3",0.006,4.51,1,1,1,1,1006,107.1,9.11,473,,1,,metabolic process;regulation of biological process,cytoplasm;cytosol;membrane,catalytic activity;protein binding,"Pf03372, Pf07888",27124,ENSG00000185133.13,INPP5J,22,Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system,,"Synthesis of PIPs at the plasma membrane; Synthesis of IP3 and IP4 in the cytosol; Synthesis of IP2, IP, and Ins in the cytosol",11,High,1
Q13535,Serine/threonine-protein kinase ATR OS=Homo sapiens OX=9606 GN=ATR PE=1 SV=3,0.006,4.51,1,2,15,2,2644,301.2,7.43,5393,,2,,development;metabolic process;regulation of biological process;response to stimulus,chromosome;Golgi;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding,"Pf00454, Pf02259, Pf02260, Pf08064",545,ENSG00000175054.14,ATR,3,HTLV-I infection; Cell cycle; p53 signaling pathway; Fanconi anemia pathway,miRNA Regulation of DNA Damage Response; Cell Cycle; ATR Signaling; ATM Signaling Network in Development and Disease; DNA Damage Response,G2/M DNA damage checkpoint; Regulation of HSF1-mediated heat shock response; Presynaptic phase of homologous DNA pairing and strand exchange; Fanconi Anemia Pathway; Meiotic synapsis; Activation of ATR in response to replication stress; TP53 Regulates Transcription of DNA Repair Genes; Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); Regulation of TP53 Activity through Phosphorylation,38,High,1
Q9NW64,Pre-mRNA-splicing factor RBM22 OS=Homo sapiens OX=9606 GN=RBM22 PE=1 SV=1,0.006,4.509,1,1,8,1,420,46.9,8.54,4244,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;nucleus;spliceosomal complex,metal ion binding;nucleotide binding;protein binding;RNA binding;transporter activity,"Pf00076, Pf13893, Pf14259",55696,ENSG00000086589.11,RBM22,5,Spliceosome,,mRNA Splicing - Major Pathway,5,High,1
Q8N2H3,Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=PYROXD2 PE=1 SV=2,0.006,4.505,6,2,2,2,581,63,6.95,528,,2,,metabolic process,,catalytic activity;nucleotide binding;protein binding,"Pf00890, Pf01134, Pf01266, Pf01593, Pf01946, Pf07992, Pf13450, Pf13738",84795,ENSG00000119943.12,PYROXD2,10,,,,0,High,1
Q96PV0,Ras/Rap GTPase-activating protein SynGAP OS=Homo sapiens OX=9606 GN=SYNGAP1 PE=1 SV=4,0.006,4.502,1,2,9,1,1343,148.2,8.98,2917,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane,enzyme regulator activity;protein binding;transporter activity,"Pf00168, Pf00169, Pf00430, Pf00616, Pf00769, Pf02463, Pf05103, Pf09744, Pf12004, Pf12037, Pf12718, Pf15346",8831,ENSG00000227460.8; ENSG00000197283.14,SYNGAP1,6; CHR_HSCHR6_MHC_SSTO_CTG1,Ras signaling pathway,,Regulation of RAS by GAPs; Signaling by RAS mutants; Interleukin-20 family signaling,14,High,1
P78509,Reelin OS=Homo sapiens OX=9606 GN=RELN PE=1 SV=3,0.006,4.498,0,2,12,2,3460,388.1,5.88,3944,,2,,cell differentiation;cell organization and biogenesis;cellular component movement;development;metabolic process;regulation of biological process;response to stimulus,cytoplasm;extracellular;membrane,catalytic activity;metal ion binding;protein binding,"Pf02014, Pf07974",5649,ENSG00000189056.13,RELN,7,Focal adhesion; PI3K-Akt signaling pathway; ECM-receptor interaction,Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,Reelin signalling pathway,8,High,1
Q7Z745,Maestro heat-like repeat-containing protein family member 2B OS=Homo sapiens OX=9606 GN=MROH2B PE=2 SV=3,0.006,4.496,1,1,242,1,1585,180.7,6.28,93632,,1,,cell differentiation;regulation of biological process;response to stimulus,cytoplasm,,,133558,ENSG00000171495.16,HEATR7B2; MROH2B,5,,,,0,High,1
O75888,Tumor necrosis factor ligand superfamily member 13 OS=Homo sapiens OX=9606 GN=TNFSF13 PE=1 SV=1,0.006,4.491,6,1,1,1,250,27.4,9.63,506,,1,,regulation of biological process;response to stimulus,cytoplasm;cytosol;extracellular;membrane,protein binding,Pf00229,8741,ENSG00000161955.16,TNFSF13,17,Rheumatoid arthritis; Cytokine-cytokine receptor interaction; Intestinal immune network for IgA production,Spinal Cord Injury,TNFs bind their physiological receptors; HuR (ELAVL1) binds and stabilizes mRNA,11,High,1
Q14CZ7,"FAST kinase domain-containing protein 3, mitochondrial OS=Homo sapiens OX=9606 GN=FASTKD3 PE=1 SV=2",0.006,4.489,2,1,5,1,662,75.6,8.29,1656,,1,,metabolic process,mitochondrion;nucleus,catalytic activity;protein binding;RNA binding,"Pf06743, Pf08368, Pf08373",79072,ENSG00000124279.11,FASTKD3,5,,,,0,High,1
O95415,Brain protein I3 OS=Homo sapiens OX=9606 GN=BRI3 PE=1 SV=1,0.006,4.489,44,2,6,2,125,13.6,8.32,819,,2,,transport,membrane;vacuole,protein binding,Pf10164,25798,ENSG00000164713.9,BRI3,7,,,Neutrophil degranulation,3,High,1
Q92845,Kinesin-associated protein 3 OS=Homo sapiens OX=9606 GN=KIFAP3 PE=1 SV=2,0.006,4.488,3,2,5,1,792,91.1,5.08,1552,,2,,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport,chromosome;cytoskeleton;cytosol;endoplasmic reticulum;Golgi,protein binding,Pf05804,22920,ENSG00000075945.12,KIFAP3,1,,,Translocation of GLUT4 to the plasma membrane; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; Intraflagellar transport; MHC class II antigen presentation,15,High,1
Q96Q15,Serine/threonine-protein kinase SMG1 OS=Homo sapiens OX=9606 GN=SMG1 PE=1 SV=3,0.006,4.488,1,2,4,2,3661,410.2,6.46,1044,,2,,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus,catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding,"Pf00454, Pf02260",23049,ENSG00000157106.16,SMG1,16,mRNA surveillance pathway,,Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC),4,High,1
Q8WUY8,N-acetyltransferase 14 OS=Homo sapiens OX=9606 GN=NAT14 PE=1 SV=1,0.006,4.483,9,1,1,1,206,21.6,10.74,659,,1,,metabolic process;regulation of biological process,membrane;nucleus,catalytic activity;DNA binding,,57106,ENSG00000090971.4,NAT14,19,,Metapathway biotransformation,,1,High,1
P56524,Histone deacetylase 4 OS=Homo sapiens OX=9606 GN=HDAC4 PE=1 SV=3,0.006,4.477,1,1,15,1,1084,119,6.96,5919,,1,,cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding,"Pf00850, Pf02841, Pf09731, Pf12203, Pf12474, Pf13868",9759,ENSG00000068024.16,HDAC4,2,Epstein-Barr virus infection; Viral carcinogenesis; Alcoholism; MicroRNAs in cancer,MicroRNAs in cardiomyocyte hypertrophy; Cell Cycle; TarBasePathway; Neural Crest Differentiation; Cardiac Hypertrophic Response; Initiation of transcription and translation elongation at the HIV-1 LTR; ATM Signaling Network in Development and Disease; VEGFA-VEGFR2 Signaling Pathway; Endochondral Ossification,NOTCH1 Intracellular Domain Regulates Transcription; SUMOylation of chromatin organization proteins; RUNX2 regulates chondrocyte maturation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; RUNX3 regulates p14-ARF; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants,37,High,1
Q9H974,Queuine tRNA-ribosyltransferase accessory subunit 2 OS=Homo sapiens OX=9606 GN=QTRT2 PE=1 SV=1,0.006,4.475,4,1,2,1,415,46.7,6.81,840,,1,,metabolic process,cytoplasm;membrane;mitochondrion,catalytic activity;metal ion binding;protein binding,Pf01702,79691,ENSG00000151576.10,QTRTD1; QTRT2,3,,,tRNA modification in the nucleus and cytosol,3,High,1
P98173,Protein FAM3A OS=Homo sapiens OX=9606 GN=FAM3A PE=1 SV=2,0.006,4.474,5,1,1,1,230,25.1,8.68,411,,1,,defense response;response to stimulus,extracellular,,,60343,ENSG00000071889.16,FAM3A,X,,,,0,High,1
Q9BV40,Vesicle-associated membrane protein 8 OS=Homo sapiens OX=9606 GN=VAMP8 PE=1 SV=1,0.006,4.468,22,2,5,2,100,11.4,7.34,1352,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytosol;endosome;membrane;vacuole,protein binding,Pf00957,8673,ENSG00000118640.10,VAMP8,2,Platelet activation; SNARE interactions in vesicular transport,,Cargo recognition for clathrin-mediated endocytosis; Neutrophil degranulation; ER-Phagosome pathway; Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis,17,High,1
Q6ZW31,Rho GTPase-activating protein SYDE1 OS=Homo sapiens OX=9606 GN=SYDE1 PE=1 SV=1,0.006,4.468,1,1,2,1,735,79.7,8.43,867,,1,,regulation of biological process;response to stimulus,cytoplasm;cytosol,enzyme regulator activity,Pf00620,85360,ENSG00000105137.12,SYDE1,19,,,Rho GTPase cycle,3,High,1
Q15464,SH2 domain-containing adapter protein B OS=Homo sapiens OX=9606 GN=SHB PE=1 SV=2,0.006,4.463,3,2,14,2,509,55,8.9,5394,,2,,cell death;cell differentiation;cell proliferation;development;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,protein binding,Pf00017,6461,ENSG00000107338.9,SHB,9,,VEGFA-VEGFR2 Signaling Pathway,VEGFA-VEGFR2 Pathway,5,High,1
Q9UK22,F-box only protein 2 OS=Homo sapiens OX=9606 GN=FBXO2 PE=1 SV=2,0.006,4.456,4,1,1,1,296,33.3,4.37,583,,1,,metabolic process;regulation of biological process,cytoplasm;cytosol;endoplasmic reticulum;membrane,catalytic activity;protein binding,Pf04300,26232,ENSG00000116661.9,FBXO2,1,Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum,,Antigen processing: Ubiquitination & Proteasome degradation; Neddylation,9,High,1
Q9P2K6,Kelch-like protein 42 OS=Homo sapiens OX=9606 GN=KLHL42 PE=1 SV=2,0.006,4.452,4,2,4,2,505,56.8,5.74,1524,,2,,cell division;metabolic process;regulation of biological process,cytoplasm;cytoskeleton;cytosol,catalytic activity;protein binding,"Pf00651, Pf01344, Pf07707, Pf13415, Pf13418, Pf13854, Pf13964",57542,ENSG00000087448.9,KLHDC5; KLHL42,12,,,Antigen processing: Ubiquitination & Proteasome degradation; Neddylation,7,High,1
Q9UHJ6,Sedoheptulokinase OS=Homo sapiens OX=9606 GN=SHPK PE=1 SV=3,0.006,4.45,2,1,3,1,478,51.5,6.83,1008,,1,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,catalytic activity;nucleotide binding,Pf00370,23729,,SHPK,17,,,Pentose phosphate pathway (hexose monophosphate shunt),3,High,1
Q96PP9,Guanylate-binding protein 4 OS=Homo sapiens OX=9606 GN=GBP4 PE=2 SV=2,0.006,4.448,2,1,3,1,640,73.1,6.02,1162,,1,,,cytoplasm;Golgi;membrane;nucleus,catalytic activity;nucleotide binding,"Pf02263, Pf02841",115361,ENSG00000162654.8,GBP4,1,NOD-like receptor signaling pathway,,Interferon gamma signaling,5,High,1
O43929,Origin recognition complex subunit 4 OS=Homo sapiens OX=9606 GN=ORC4 PE=1 SV=2,0.006,4.445,3,1,3,1,436,50.3,8,1255,,1,,metabolic process,cytosol;nucleus,DNA binding;nucleotide binding;protein binding,"Pf00004, Pf01637, Pf13173, Pf13191, Pf13304, Pf13401, Pf14516, Pf14629",5000,ENSG00000115947.13,ORC4,2,Cell cycle,Cell Cycle; G1 to S cell cycle control; DNA Replication,M/G1 Transition; CDT1 association with the CDC6:ORC:origin complex; Regulation of DNA replication; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDC6 association with the ORC:origin complex; Association of licensing factors with the pre-replicative complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication; Orc1 removal from chromatin; Removal of licensing factors from origins,28,High,1
Q8N126,Cell adhesion molecule 3 OS=Homo sapiens OX=9606 GN=CADM3 PE=1 SV=1,0.006,4.443,5,1,9,1,398,43.3,6.09,4144,,1,,cell organization and biogenesis,membrane,protein binding;receptor activity,"Pf00047, Pf07654, Pf07679, Pf08205, Pf13895, Pf13927",57863,ENSG00000162706.12,CADM3,1,Cell adhesion molecules (CAMs),,Nectin/Necl  trans heterodimerization,6,High,1
P35475,Alpha-L-iduronidase OS=Homo sapiens OX=9606 GN=IDUA PE=1 SV=2,0.006,4.441,1,1,7,1,653,72.6,9.14,3548,,1,,metabolic process,organelle lumen;vacuole,catalytic activity;protein binding,Pf01229,3425,ENSG00000127415.12,IDUA,4,Metabolic pathways; Lysosome; Glycosaminoglycan degradation,,CS/DS degradation; HS-GAG degradation; MPS I - Hurler syndrome,15,High,1
Q8N4X5,Actin filament-associated protein 1-like 2 OS=Homo sapiens OX=9606 GN=AFAP1L2 PE=1 SV=1,0.006,4.439,2,2,4,2,818,91.2,5.31,1338,,2,,defense response;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,enzyme regulator activity;protein binding,"Pf00169, Pf15413",84632,ENSG00000169129.14,AFAP1L2,10,,,,0,High,1
Q96JP5,E3 ubiquitin-protein ligase ZFP91 OS=Homo sapiens OX=9606 GN=ZFP91 PE=1 SV=1,0.007,4.437,2,1,4,1,570,63.4,7.36,1420,,1,,metabolic process;regulation of biological process,nucleus,catalytic activity;metal ion binding,Pf13465,80829,ENSG00000186660.14,ZFP91,11,,,,0,High,1
Q9Y561,Low-density lipoprotein receptor-related protein 12 OS=Homo sapiens OX=9606 GN=LRP12 PE=1 SV=1,0.007,4.436,2,1,1,1,859,94.9,5.24,448,,1,,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport,membrane,protein binding;receptor activity,"Pf00057, Pf00431, Pf12999",29967,ENSG00000147650.11,LRP12,8,,,Signaling by GPCR; Retinoid metabolism and transport,7,High,1
Q8IUK5,Plexin domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PLXDC1 PE=1 SV=2,0.007,4.429,3,1,5,1,500,55.7,5.85,1900,,1,,,cytoplasm;extracellular;membrane,protein binding,Pf01437,57125,ENSG00000161381.13,PLXDC1,17,,,,0,High,1
Q9H6L2,Transmembrane protein 231 OS=Homo sapiens OX=9606 GN=TMEM231 PE=1 SV=1,0.007,4.425,4,1,2,1,316,36,7.94,687,,1,,cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus,membrane,protein binding,Pf10149,79583,ENSG00000205084.10,TMEM231,16,,,,0,High,1
A8MVU1,Putative neutrophil cytosol factor 1C OS=Homo sapiens OX=9606 GN=NCF1C PE=5 SV=1,0.007,4.417,2,1,3,1,366,41.8,8.84,1286,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm,catalytic activity;enzyme regulator activity;protein binding,"Pf00018, Pf00787, Pf07653, Pf08944, Pf14604",654817,,NCF1C,7,,,,0,High,1
P28347,Transcriptional enhancer factor TEF-1 OS=Homo sapiens OX=9606 GN=TEAD1 PE=1 SV=2,0.007,4.416,3,1,1,1,426,47.9,8.15,529,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,nucleus,DNA binding;protein binding,Pf01285,7003,ENSG00000187079.16,TEAD1,11,Hippo signaling pathway -multiple species; Hippo signaling pathway,Mesodermal Commitment Pathway; miR-509-3p alteration of YAP1/ECM axis,YAP1- and WWTR1 (TAZ)-stimulated gene expression; PPARA activates gene expression; RUNX3 regulates YAP1-mediated transcription,14,High,1
O43353,Receptor-interacting serine/threonine-protein kinase 2 OS=Homo sapiens OX=9606 GN=RIPK2 PE=1 SV=2,0.007,4.415,9,2,2,2,540,61.2,7.09,237,,2,,cell death;cell proliferation;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol,catalytic activity;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf00619, Pf07714",8767,ENSG00000104312.7,RIPK2,8,Neurotrophin signaling pathway; Shigellosis; NOD-like receptor signaling pathway; Tuberculosis,Nucleotide-binding Oligomerization Domain (NOD) pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation; T-Cell antigen Receptor (TCR)  Signaling Pathway,Downstream TCR signaling; NOD1/2 Signaling Pathway; Ovarian tumor domain proteases; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Activated TLR4 signalling; Interleukin-1 family signaling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; activated TAK1 mediates p38 MAPK activation; Signalling by NGF; p75NTR recruits signalling complexes,50,High,1
Q9NY64,"Solute carrier family 2, facilitated glucose transporter member 8 OS=Homo sapiens OX=9606 GN=SLC2A8 PE=1 SV=3",0.007,4.405,1,1,5,1,477,50.8,7.61,2512,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,membrane,transporter activity,"Pf00083, Pf07690",29988,ENSG00000136856.17,SLC2A8,9,,NRF2 pathway,Cargo recognition for clathrin-mediated endocytosis; Cellular hexose transport,8,High,1
Q9BU76,Multiple myeloma tumor-associated protein 2 OS=Homo sapiens OX=9606 GN=MMTAG2 PE=1 SV=1,0.007,4.403,4,1,1,1,263,29.4,10.02,447,,1,,transport,extracellular;organelle lumen,protein binding;RNA binding,Pf10159,79169,ENSG00000143793.12,C1orf35,1,,,Neutrophil degranulation,3,High,1
Q8ND04,Protein SMG8 OS=Homo sapiens OX=9606 GN=SMG8 PE=1 SV=1,0.007,4.402,2,2,4,2,991,109.6,7.68,1269,,2,,metabolic process;regulation of biological process,cytosol,protein binding,Pf10220,55181,ENSG00000167447.12,SMG8,17,,,Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC),3,High,1
O94806,Serine/threonine-protein kinase D3 OS=Homo sapiens OX=9606 GN=PRKD3 PE=1 SV=1,0.007,4.401,3,2,2,1,890,100.4,6.87,614,,2,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf00130, Pf00169, Pf07714, Pf14531",23683,ENSG00000115825.9,PRKD3,2,Rap1 signaling pathway; Aldosterone synthesis and secretion,miRs in Muscle Cell Differentiation; G Protein Signaling Pathways,Sphingolipid de novo biosynthesis,8,High,1
Q12980,GATOR complex protein NPRL3 OS=Homo sapiens OX=9606 GN=NPRL3 PE=1 SV=1,0.007,4.394,5,2,6,2,569,63.6,6.98,1299,,2,,cell communication;regulation of biological process;response to stimulus,membrane;vacuole,enzyme regulator activity,Pf03666,8131,ENSG00000103148.15,NPRL3,16,mTOR signaling pathway,,,1,High,1
Q9Y580,RNA-binding protein 7 OS=Homo sapiens OX=9606 GN=RBM7 PE=1 SV=1,0.007,4.392,7,1,2,1,266,30.5,9.57,565,,1,,regulation of biological process,nucleus,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",10179,ENSG00000076053.10,RBM7,11,,,,0,High,1
Q9NPR9,Protein GPR108 OS=Homo sapiens OX=9606 GN=GPR108 PE=2 SV=3,0.007,4.378,2,1,1,1,543,60.6,8.69,465,,1,,,membrane,,Pf06814,56927,ENSG00000125734.15,GPR108,19,,,,0,High,1
Q6PJG2,ELM2 and SANT domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ELMSAN1 PE=1 SV=2,0.007,4.375,3,2,3,2,1045,114.9,9.19,773,,2,,metabolic process;regulation of biological process,nucleus,DNA binding;protein binding,"Pf00249, Pf01448",91748,ENSG00000156030.13,ELMSAN1,14,,,,0,High,1
Q7L0Q8,Rho-related GTP-binding protein RhoU OS=Homo sapiens OX=9606 GN=RHOU PE=1 SV=1,0.007,4.357,4,1,3,1,258,28.2,8.06,1182,,1,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytosol;Golgi;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00071, Pf08477",58480,ENSG00000116574.5,RHOU,1,,,Interleukin-4 and 13 signaling; Rho GTPase cycle,7,High,1
Q9BVI4,Nucleolar complex protein 4 homolog OS=Homo sapiens OX=9606 GN=NOC4L PE=1 SV=1,0.007,4.353,3,1,3,1,516,58.4,7.49,1293,,1,,metabolic process,membrane;nucleus,protein binding;RNA binding,"Pf03914, Pf14838",79050,ENSG00000184967.6,NOC4L,12,,,Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol,5,High,1
Q8IX30,"Signal peptide, CUB and EGF-like domain-containing protein 3 OS=Homo sapiens OX=9606 GN=SCUBE3 PE=1 SV=1",0.007,4.349,1,1,1,1,993,109.2,7.56,440,,1,,cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus,cell surface;extracellular;membrane,metal ion binding;protein binding,"Pf00431, Pf06247, Pf07645, Pf07699, Pf12662, Pf12947, Pf14670",222663,ENSG00000146197.8,SCUBE3,6,,,Degradation of the extracellular matrix,2,High,1
Q9NS87,Kinesin-like protein KIF15 OS=Homo sapiens OX=9606 GN=KIF15 PE=1 SV=1,0.007,4.344,1,1,20,1,1388,160.1,6,8633,,1,,cell proliferation;cellular component movement;metabolic process;transport,cytoplasm;cytoskeleton;cytosol;membrane,catalytic activity;DNA binding;motor activity;nucleotide binding;protein binding;transporter activity,"Pf00225, Pf01496, Pf02463, Pf04111, Pf05622, Pf08317, Pf12128, Pf12711, Pf13166, Pf13514, Pf15619",56992,ENSG00000280610.2; ENSG00000163808.16,KIF15,3; CHR_HG2066_PATCH,,Gastric Cancer Network 1,COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; MHC class II antigen presentation,12,High,1
Q9BRK3,Matrix remodeling-associated protein 8 OS=Homo sapiens OX=9606 GN=MXRA8 PE=1 SV=1,0.007,4.341,4,2,2,2,442,49.1,7.23,521,,2,,metabolic process,cell surface;membrane;organelle lumen,,,54587,ENSG00000162576.16,MXRA8,1,,,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs),4,High,1
Q969T7,7-methylguanosine phosphate-specific 5'-nucleotidase OS=Homo sapiens OX=9606 GN=NT5C3B PE=1 SV=4,0.007,4.341,3,1,12,1,300,34.4,6.38,4851,,1,,metabolic process,cytoplasm;cytosol,catalytic activity;metal ion binding;nucleotide binding;protein binding,Pf05822,115024,ENSG00000141698.16,NT5C3B; NT5C3L,17,Pyrimidine metabolism; Nicotinate and nicotinamide metabolism; Metabolic pathways; Purine metabolism,,mRNA decay by 3' to 5' exoribonuclease,7,High,1
O95639,Cleavage and polyadenylation specificity factor subunit 4 OS=Homo sapiens OX=9606 GN=CPSF4 PE=1 SV=1,0.007,4.338,4,1,6,1,269,30.2,8.31,2351,,1,,metabolic process;regulation of biological process;transport,nucleus,catalytic activity;metal ion binding;protein binding;RNA binding,,10898,ENSG00000160917.14,CPSF4,7,mRNA surveillance pathway; Influenza A,mRNA Processing,Inhibition of Host mRNA Processing and RNA Silencing; mRNA 3'-end processing; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA Splicing - Major Pathway; tRNA processing in the nucleus; Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs,25,High,1
O14545,TRAF-type zinc finger domain-containing protein 1 OS=Homo sapiens OX=9606 GN=TRAFD1 PE=1 SV=1,0.007,4.335,2,1,4,1,582,64.8,5.29,1424,,1,,regulation of biological process;response to stimulus,,metal ion binding;protein binding,,10906,ENSG00000135148.11,TRAFD1,12,,Regulation of toll-like receptor signaling pathway,,1,High,1
P28845,Corticosteroid 11-beta-dehydrogenase isozyme 1 OS=Homo sapiens OX=9606 GN=HSD11B1 PE=1 SV=3,0.007,4.333,4,1,3,1,292,32.4,8.56,1532,,1,,metabolic process,endoplasmic reticulum;membrane,catalytic activity,"Pf00106, Pf08659, Pf13561",3290,ENSG00000117594.9,HSD11B1,1,Steroid hormone biosynthesis; Metabolism of xenobiotics by cytochrome P450; Metabolic pathways; Chemical carcinogenesis,Glucocorticoid & Mineralcorticoid Metabolism; Prostaglandin Synthesis and Regulation,Glucocorticoid biosynthesis,11,High,1
P35557,Hexokinase-4 OS=Homo sapiens OX=9606 GN=GCK PE=1 SV=1,0.007,4.333,5,1,2,1,465,52.2,5.2,1032,,1,,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;mitochondrion;nucleus,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding,"Pf00349, Pf03727",2645,ENSG00000106633.15,GCK,7,"Type II diabetes mellitus; Prolactin signaling pathway; Metabolic pathways; Insulin signaling pathway; Starch and sucrose metabolism; Insulin secretion; Galactose metabolism; Central carbon metabolism in cancer; Amino sugar and nucleotide sugar metabolism; Glucagon signaling pathway; Glycolysis / Gluconeogenesis; Neomycin, kanamycin and gentamicin biosynthesis; Maturity onset diabetes of the young; Carbon metabolism",MAPK Signaling Pathway; Glycolysis and Gluconeogenesis; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,Regulation of Glucokinase by Glucokinase Regulatory Protein; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); Regulation of gene expression in beta cells; Defective GCK causes maturity-onset diabetes of the young 2 (MODY2),30,High,1
Q6NSJ5,Volume-regulated anion channel subunit LRRC8E OS=Homo sapiens OX=9606 GN=LRRC8E PE=1 SV=2,0.007,4.327,3,2,4,1,796,90.2,6.96,767,,2,,regulation of biological process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;membrane,protein binding;transporter activity,"Pf12534, Pf12799, Pf13855",80131,ENSG00000171017.10,LRRC8E,19,,,Miscellaneous transport and binding events,2,High,1
Q96NU0,Contactin-associated protein-like 3B OS=Homo sapiens OX=9606 GN=CNTNAP3B PE=2 SV=3,0.007,4.325,2,2,6,2,1288,140.3,7.4,1557,,2,,,,,,,,,,,,,0,High,1
Q9BZF3,Oxysterol-binding protein-related protein 6 OS=Homo sapiens OX=9606 GN=OSBPL6 PE=1 SV=1,0.007,4.306,1,1,2,1,934,106.2,6.93,801,,1,,metabolic process;transport,cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus,protein binding;transporter activity,"Pf00169, Pf01237, Pf15409",114880,ENSG00000079156.16,OSBPL6,2,,,Synthesis of bile acids and bile salts,5,High,1
Q14331,Protein FRG1 OS=Homo sapiens OX=9606 GN=FRG1 PE=1 SV=1,0.007,4.299,5,1,3,1,258,29.2,9.01,980,,1,,metabolic process,cytoplasm;nucleus;spliceosomal complex,protein binding;RNA binding,"Pf06229, Pf06268",2483,ENSG00000283153.1; ENSG00000283630.1; ENSG00000109536.11; ENSG00000275145.3,FRG1,4; CHR_HG2023_PATCH; CHR_HSCHR4_11_CTG12; CHR_HSCHR4_6_CTG12,,,,0,High,1
Q9UM13,Anaphase-promoting complex subunit 10 OS=Homo sapiens OX=9606 GN=ANAPC10 PE=1 SV=1,0.007,4.299,6,1,5,1,185,21.2,9.06,1474,,1,,cell division;metabolic process;regulation of biological process,cytoplasm;cytosol,catalytic activity,Pf03256,10393,ENSG00000164162.12,ANAPC10,4,Progesterone-mediated oocyte maturation; Cell cycle; HTLV-I infection; Ubiquitin mediated proteolysis; Oocyte meiosis,,APC/C:Cdc20 mediated degradation of Cyclin B; Inactivation of APC/C via direct inhibition of the APC/C complex; Autodegradation of Cdh1 by Cdh1:APC/C; APC-Cdc20 mediated degradation of Nek2A; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Antigen processing: Ubiquitination & Proteasome degradation; Phosphorylation of the APC/C; APC/C:Cdc20 mediated degradation of Securin; Separation of Sister Chromatids; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Senescence-Associated Secretory Phenotype (SASP),37,High,1
P14151,L-selectin OS=Homo sapiens OX=9606 GN=SELL PE=1 SV=2,0.007,4.299,2,1,4,1,372,42.2,6.6,1464,,1,,cellular component movement;regulation of biological process;response to stimulus;transport,cell surface;membrane,protein binding,"Pf00008, Pf00059, Pf00084",6402,,SELL,1,Cell adhesion molecules (CAMs),,Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall,8,High,1
Q13608,Peroxisome assembly factor 2 OS=Homo sapiens OX=9606 GN=PEX6 PE=1 SV=2,0.007,4.298,2,2,4,2,980,104,6.34,1318,,2,,cell organization and biogenesis;regulation of biological process;transport,cytoplasm;cytosol;membrane,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00004, Pf00910, Pf05729, Pf07724, Pf13086, Pf13191, Pf13207, Pf13245",5190,ENSG00000124587.13,PEX6,6,Peroxisome,,,1,High,1
Q9H2A2,2-aminomuconic semialdehyde dehydrogenase OS=Homo sapiens OX=9606 GN=ALDH8A1 PE=1 SV=1,0.007,4.288,2,1,36,1,487,53.4,7.14,15776,,1,,metabolic process,cytoplasm;cytosol,catalytic activity,Pf00171,64577,ENSG00000118514.13,ALDH8A1,6,,,RA biosynthesis pathway,4,High,1
Q9H3Y8,Pancreatic progenitor cell differentiation and proliferation factor OS=Homo sapiens OX=9606 GN=PPDPF PE=1 SV=1,0.007,4.287,15,1,1,1,114,11.8,7.42,469,,1,,cell differentiation;development,,,Pf15060,79144,ENSG00000125534.9,PPDPF,20,,,,0,High,1
P51397,Death-associated protein 1 OS=Homo sapiens OX=9606 GN=DAP PE=1 SV=3,0.007,4.287,27,1,1,1,102,11.2,9.32,433,,1,,cell communication;cell death;metabolic process;regulation of biological process;response to stimulus,,protein binding,Pf15228,1611,ENSG00000112977.15,DAP,5,,,,0,High,1
O94804,Serine/threonine-protein kinase 10 OS=Homo sapiens OX=9606 GN=STK10 PE=1 SV=1,0.007,4.281,3,2,5,2,968,112.1,6.95,1318,,2,,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf02463, Pf04111, Pf07714, Pf12128, Pf12474, Pf13868, Pf13904",6793,ENSG00000072786.12,STK10,5,,,Neutrophil degranulation,3,High,1
O95907,Monocarboxylate transporter 3 OS=Homo sapiens OX=9606 GN=SLC16A8 PE=2 SV=1,0.007,4.28,2,1,15,1,504,52.3,5.67,7882,,1,,cellular component movement;metabolic process;transport,membrane,transporter activity,,23539,ENSG00000100156.10,SLC16A8,22,,,Proton-coupled monocarboxylate transport; Basigin interactions; Pyruvate metabolism,11,High,1
P42696,RNA-binding protein 34 OS=Homo sapiens OX=9606 GN=RBM34 PE=1 SV=2,0.007,4.279,5,2,8,2,430,48.5,10.11,2836,,2,,,nucleus,RNA binding,"Pf00076, Pf14259",23029,ENSG00000188739.14,RBM34,1,,,,0,High,1
P98153,Integral membrane protein DGCR2/IDD OS=Homo sapiens OX=9606 GN=DGCR2 PE=1 SV=1,0.007,4.271,3,1,1,1,550,60.8,5.3,398,,1,,,membrane,protein binding,"Pf00057, Pf00059",9993,ENSG00000070413.19,DGCR2,22,,,,0,High,1
Q9Y239,Nucleotide-binding oligomerization domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NOD1 PE=1 SV=1,0.007,4.269,1,2,8,2,953,107.6,7.11,2781,,2,,cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,enzyme regulator activity;nucleotide binding;protein binding,"Pf00619, Pf05729",10392,ENSG00000106100.10,NOD1,7,Epithelial cell signaling in Helicobacter pylori infection; Shigellosis; NOD-like receptor signaling pathway; Pertussis,Nucleotide-binding Oligomerization Domain (NOD) pathway,NOD1/2 Signaling Pathway; Ovarian tumor domain proteases; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Activated TLR4 signalling; Interleukin-1 family signaling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; activated TAK1 mediates p38 MAPK activation,38,High,1
Q5TFQ8,Signal-regulatory protein beta-1 isoform 3 OS=Homo sapiens OX=9606 GN=SIRPB1 PE=1 SV=1,0.007,4.262,4,1,15,1,398,43.3,7.83,5809,,1,,defense response;regulation of biological process;response to stimulus;transport,membrane,protein binding,"Pf00047, Pf07654, Pf07679, Pf07686, Pf08205",10326,ENSG00000101307.15,SIRPB1,20,Osteoclast differentiation,,,1,High,1
Q8NCG7,Sn1-specific diacylglycerol lipase beta OS=Homo sapiens OX=9606 GN=DAGLB PE=1 SV=2,0.007,4.259,2,1,3,1,672,73.7,6.55,1298,,1,,cell differentiation;cell proliferation;metabolic process,membrane;nucleus,catalytic activity;metal ion binding,Pf01764,221955,ENSG00000164535.14,DAGLB,7,Aldosterone synthesis and secretion; Retrograde endocannabinoid signaling,,Arachidonate production from DAG; Gastrin-CREB signalling pathway via PKC and MAPK,11,High,1
Q9BRZ2,E3 ubiquitin-protein ligase TRIM56 OS=Homo sapiens OX=9606 GN=TRIM56 PE=1 SV=3,0.008,4.247,4,2,4,2,755,81.4,7.74,1203,,2,,defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,catalytic activity;metal ion binding;protein binding;RNA binding,"Pf00097, Pf00643, Pf13445, Pf13639, Pf13920, Pf13923, Pf14634, Pf15227",81844,ENSG00000169871.12,TRIM56,7,,,Regulation of innate immune responses to cytosolic DNA,4,High,1
Q92834,X-linked retinitis pigmentosa GTPase regulator OS=Homo sapiens OX=9606 GN=RPGR PE=1 SV=2,0.008,4.245,1,1,2,1,1020,113.3,4.86,749,,1,,cell organization and biogenesis;cellular component movement;response to stimulus;transport,cytoplasm;cytoskeleton;Golgi,protein binding;RNA binding,"Pf00415, Pf13540",6103,ENSG00000156313.12,RPGR,X,,,,0,High,1
Q9NUP1,Biogenesis of lysosome-related organelles complex 1 subunit 4 OS=Homo sapiens OX=9606 GN=BLOC1S4 PE=1 SV=1,0.008,4.242,6,1,1,1,217,23.3,4.98,554,,1,,cell organization and biogenesis;cellular component movement;transport,cytoplasm;cytosol,protein binding,,55330,ENSG00000186222.4,BLOC1S4,4,,,Golgi Associated Vesicle Biogenesis,5,High,1
Q8NDX5,Polyhomeotic-like protein 3 OS=Homo sapiens OX=9606 GN=PHC3 PE=1 SV=1,0.008,4.239,3,2,4,2,983,106.1,6.62,1093,,2,,development;regulation of biological process,nucleus,DNA binding;metal ion binding;protein binding,"Pf00536, Pf07647",80012,ENSG00000173889.15,PHC3,3,,,RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; SUMOylation of chromatin organization proteins; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; SUMOylation of DNA damage response and repair proteins; Oxidative Stress Induced Senescence; SUMOylation of RNA binding proteins,22,High,1
O60704,Protein-tyrosine sulfotransferase 2 OS=Homo sapiens OX=9606 GN=TPST2 PE=1 SV=1,0.008,4.23,3,1,2,1,377,41.9,9.09,730,,1,,metabolic process,endoplasmic reticulum;Golgi;membrane,catalytic activity;protein binding,"Pf04320, Pf13469",8459,ENSG00000128294.15,TPST2,22,,,Cytosolic sulfonation of small molecules,4,High,1
Q8WU79,Stromal membrane-associated protein 2 OS=Homo sapiens OX=9606 GN=SMAP2 PE=1 SV=1,0.008,4.229,6,2,2,2,429,46.8,8.87,557,,2,,regulation of biological process,cytoplasm,enzyme regulator activity;metal ion binding;protein binding,Pf01412,64744,ENSG00000084070.11,SMAP2,1,Endocytosis,,,1,High,1
Q9UPR5,Sodium/calcium exchanger 2 OS=Homo sapiens OX=9606 GN=SLC8A2 PE=2 SV=2,0.008,4.227,1,1,18,1,921,100.3,5.15,6743,,1,,cell communication;cellular homeostasis;regulation of biological process;response to stimulus;transport,membrane,metal ion binding;protein binding;transporter activity,"Pf01699, Pf03160",6543,ENSG00000118160.13,SLC8A2,19,cGMP-PKG signaling pathway; Calcium signaling pathway; Olfactory transduction; Protein digestion and absorption,,Ion homeostasis; Reduction of cytosolic Ca++ levels; Sodium/Calcium exchangers,15,High,1
P55081,Microfibrillar-associated protein 1 OS=Homo sapiens OX=9606 GN=MFAP1 PE=1 SV=2,0.008,4.219,3,1,2,1,439,51.9,4.98,727,,1,,cell organization and biogenesis,extracellular;nucleus;spliceosomal complex,protein binding;RNA binding,Pf06991,4236,ENSG00000140259.6,MFAP1,15,,Canonical  and Non-canonical Notch signaling,Molecules associated with elastic fibres,4,High,1
Q9BQD7,Adenine nucleotide translocase lysine N-methyltransferase OS=Homo sapiens OX=9606 GN=ANTKMT PE=1 SV=1,0.008,4.216,12,2,4,2,235,25.1,9.32,952,,2,,,membrane,,,65990,ENSG00000103254.9,FAM173A,16,,,,0,High,1
Q92608,Dedicator of cytokinesis protein 2 OS=Homo sapiens OX=9606 GN=DOCK2 PE=1 SV=2,0.008,4.216,1,2,13,2,1830,211.8,6.87,3967,,2,,cell organization and biogenesis;cell proliferation;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;extracellular;membrane;organelle lumen,enzyme regulator activity;protein binding,"Pf00018, Pf06920, Pf07653, Pf14429, Pf14604",1794,ENSG00000134516.15,DOCK2,5,Fc gamma R-mediated phagocytosis; Chemokine signaling pathway,Chemokine signaling pathway,Neutrophil degranulation; Factors involved in megakaryocyte development and platelet production; Nef and signal transduction,14,High,1
P36537,UDP-glucuronosyltransferase 2B10 OS=Homo sapiens OX=9606 GN=UGT2B10 PE=1 SV=1,0.008,4.214,5,2,4,1,528,60.7,9,1033,,2,,metabolic process,endoplasmic reticulum;membrane,catalytic activity,Pf00201,7365,ENSG00000109181.11; ENSG00000275190.3,UGT2B10,4; CHR_HSCHR4_1_CTG9,Metabolism of xenobiotics by cytochrome P450; Drug metabolism - other enzymes; Retinol metabolism; Pentose and glucuronate interconversions; Drug metabolism - cytochrome P450; Porphyrin and chlorophyll metabolism; Steroid hormone biosynthesis; Ascorbate and aldarate metabolism; Metabolic pathways; Chemical carcinogenesis,Glucuronidation,Glucuronidation,15,High,1
O14975,Very long-chain acyl-CoA synthetase OS=Homo sapiens OX=9606 GN=SLC27A2 PE=1 SV=2,0.008,4.213,1,1,53,1,620,70.3,8.51,22575,,1,,metabolic process;transport,endoplasmic reticulum;membrane;mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding;transporter activity,"Pf00501, Pf13193",11001,ENSG00000140284.10,SLC27A2,15,PPAR signaling pathway; Insulin resistance; Peroxisome,PPAR signaling pathway,Neutrophil degranulation; Synthesis of bile acids and bile salts via 24-hydroxycholesterol; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Alpha-oxidation of phytanate,17,High,1
Q8TEA7,TBC domain-containing protein kinase-like protein OS=Homo sapiens OX=9606 GN=TBCK PE=1 SV=4,0.008,4.213,2,1,3,1,893,100.6,6.58,1445,,1,,cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding,"Pf00069, Pf00566, Pf00581, Pf07714, Pf14531",93627,ENSG00000145348.16,TBCK,4,,,,0,High,1
Q969E2,Secretory carrier-associated membrane protein 4 OS=Homo sapiens OX=9606 GN=SCAMP4 PE=1 SV=1,0.008,4.209,5,1,1,1,229,25.7,8.82,477,,1,,transport,membrane,,Pf04144,113178,ENSG00000227500.9,SCAMP4,19,,,,0,High,1
Q9UBB9,Tuftelin-interacting protein 11 OS=Homo sapiens OX=9606 GN=TFIP11 PE=1 SV=1,0.008,4.206,3,1,2,1,837,96.8,5.67,430,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus;spliceosomal complex,DNA binding;protein binding,"Pf01585, Pf07842, Pf12457, Pf12656",24144,ENSG00000100109.16,TFIP11,22,,,mRNA Splicing - Major Pathway,4,High,1
P51617,Interleukin-1 receptor-associated kinase 1 OS=Homo sapiens OX=9606 GN=IRAK1 PE=1 SV=2,0.008,4.204,2,1,1,1,712,76.5,6.62,498,,1,,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf00531, Pf07714",3654,ENSG00000184216.13,IRAK1,X,Pertussis; Neurotrophin signaling pathway; Toll-like receptor signaling pathway; NF-kappa B signaling pathway; Chagas disease (American trypanosomiasis); Toxoplasmosis; Tuberculosis; Leishmaniasis; Epstein-Barr virus infection; Measles,Regulation of toll-like receptor signaling pathway; IL-1 signaling pathway; EBV LMP1 signaling; Structural Pathway of Interleukin 1 (IL-1); IL1 and megakaryocytes in obesity; Melatonin metabolism and effects; Interleukin-1 Induced Activation of NF-kappa-B; TLR4 Signaling and Tolerance; Toll-like Receptor Signaling; Simplified Depiction of MYD88 Distinct Input-Output Pathway; ApoE and miR-146 in inflammation and atherosclerosis; Toll-like receptor signaling pathway,"IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; NOD1/2 Signaling Pathway; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Activated TLR4 signalling; Interleukin-1 family signaling; IRAK1 recruits IKK complex; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling; activated TAK1 mediates p38 MAPK activation; NF-kB is activated and signals survival; Signalling by NGF; p75NTR recruits signalling complexes",65,High,1
Q6PJ69,Tripartite motif-containing protein 65 OS=Homo sapiens OX=9606 GN=TRIM65 PE=1 SV=3,0.008,4.203,3,1,2,1,517,57.3,6.7,566,,1,,metabolic process;regulation of biological process;transport,cytosol;nucleus,metal ion binding;protein binding;transporter activity,"Pf00097, Pf00430, Pf00622, Pf13445, Pf13639, Pf13920, Pf13923, Pf14634, Pf14835, Pf15227",201292,ENSG00000141569.10,TRIM65,17,,,,0,High,1
Q8IWZ8,SURP and G-patch domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SUGP1 PE=1 SV=2,0.008,4.2,3,2,6,2,645,72.4,7.61,1712,,2,,metabolic process,nucleus;spliceosomal complex,protein binding;RNA binding,"Pf01585, Pf01805, Pf12656",57794,ENSG00000105705.15,SUGP1,19,,mRNA Processing,mRNA Splicing - Major Pathway,5,High,1
Q9HAU8,Aminopeptidase RNPEPL1 OS=Homo sapiens OX=9606 GN=RNPEPL1 PE=1 SV=3,0.008,4.199,2,1,1,1,725,79.9,5.19,323,,1,,metabolic process,cytoplasm,catalytic activity;metal ion binding,"Pf01433, Pf09127, Pf13485",57140,ENSG00000142327.12,RNPEPL1,2,,,,0,High,1
Q5BJF6,Outer dense fiber protein 2 OS=Homo sapiens OX=9606 GN=ODF2 PE=1 SV=1,0.008,4.189,1,1,3,1,829,95.3,7.62,1270,,1,,cell differentiation;cell organization and biogenesis;development;metabolic process;regulation of biological process,cytoplasm;cytoskeleton;cytosol;nucleus,catalytic activity;motor activity;protein binding;structural molecule activity,"Pf00038, Pf01576, Pf02463, Pf03962, Pf04111, Pf05557, Pf05701, Pf07888, Pf10174, Pf12128, Pf13514",4957,ENSG00000136811.16,ODF2,9,,,Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes,16,High,1
Q9UL45,Biogenesis of lysosome-related organelles complex 1 subunit 6 OS=Homo sapiens OX=9606 GN=BLOC1S6 PE=1 SV=1,0.008,4.186,11,1,6,1,172,19.7,6.4,1206,0,1,1,cell organization and biogenesis;cellular component movement;regulation of biological process;transport,cytoplasm;cytosol;membrane,protein binding,Pf14712,26258,ENSG00000104164.10,BLOC1S6,15,,,Golgi Associated Vesicle Biogenesis,5,High,1
Q15291,Retinoblastoma-binding protein 5 OS=Homo sapiens OX=9606 GN=RBBP5 PE=1 SV=2,0.008,4.184,3,2,5,2,538,59.1,5.1,1700,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,nucleus,catalytic activity;DNA binding;protein binding,Pf00400,5929,ENSG00000117222.13,RBBP5,1,,,Deactivation of the beta-catenin transactivating complex; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; PKMTs methylate histone lysines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Formation of the beta-catenin:TCF transactivating complex; Neddylation,19,High,1
P11168,"Solute carrier family 2, facilitated glucose transporter member 2 OS=Homo sapiens OX=9606 GN=SLC2A2 PE=1 SV=1",0.008,4.184,4,2,16,2,524,57.5,7.97,4619,,2,,metabolic process;regulation of biological process;transport,cytoplasm;membrane,transporter activity,"Pf00083, Pf01770, Pf07690, Pf13347",6514,ENSG00000163581.13,SLC2A2,3,Carbohydrate digestion and absorption; Prolactin signaling pathway; Insulin secretion; Maturity onset diabetes of the young; Central carbon metabolism in cancer; Insulin resistance; Glucagon signaling pathway; Type II diabetes mellitus,Type II diabetes mellitus; Cori Cycle; NRF2 pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Glycolysis and Gluconeogenesis,Cellular hexose transport; Intestinal hexose absorption; Regulation of insulin secretion; Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS); Regulation of gene expression in beta cells,29,High,1
Q96I23,"Protein preY, mitochondrial OS=Homo sapiens OX=9606 GN=PYURF PE=1 SV=1",0.008,4.181,19,1,3,1,114,12.6,9.33,,0,,1,metabolic process;regulation of biological process,membrane;mitochondrion,protein binding,Pf03966,100996939,ENSG00000145337.4,PYURF,4,,,,0,High,1
O00187,Mannan-binding lectin serine protease 2 OS=Homo sapiens OX=9606 GN=MASP2 PE=1 SV=4,0.008,4.178,1,1,3,1,686,75.7,5.63,1243,,1,,defense response;metabolic process;regulation of biological process;response to stimulus,extracellular,catalytic activity;metal ion binding;protein binding,"Pf00084, Pf00089, Pf00431, Pf07645, Pf12662, Pf14670",10747,ENSG00000009724.16,MASP2,1,Complement and coagulation cascades; Staphylococcus aureus infection,Complement Activation; Complement and Coagulation Cascades,Ficolins bind to repetitive carbohydrate structures on the target cell surface,11,High,1
Q8IU81,Interferon regulatory factor 2-binding protein 1 OS=Homo sapiens OX=9606 GN=IRF2BP1 PE=1 SV=1,0.008,4.169,3,1,4,1,584,61.6,8.18,1305,,1,,metabolic process;regulation of biological process,nucleus,catalytic activity;metal ion binding;protein binding,"Pf00097, Pf11261",26145,ENSG00000170604.4,IRF2BP1,19,,,,0,High,1
Q16706,Alpha-mannosidase 2 OS=Homo sapiens OX=9606 GN=MAN2A1 PE=1 SV=2,0.008,4.166,2,2,4,2,1144,131.1,7.58,868,,2,,cell organization and biogenesis;metabolic process;regulation of biological process,Golgi;membrane,catalytic activity;metal ion binding,"Pf01074, Pf07748, Pf09261",4124,ENSG00000112893.9,MAN2A1,5,N-Glycan biosynthesis; Metabolic pathways,,Intra-Golgi traffic; Reactions specific to the complex N-glycan synthesis pathway,12,High,1
Q96BR1,Serine/threonine-protein kinase Sgk3 OS=Homo sapiens OX=9606 GN=SGK3 PE=1 SV=1,0.008,4.163,2,1,5,1,496,57.1,6.93,1843,,1,,metabolic process;regulation of biological process;response to stimulus;transport,cytosol;endosome,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf00433, Pf00787, Pf07714, Pf14531",23678; 100533105,ENSG00000270024.5; ENSG00000104205.12,SGK3; C8orf44-SGK3,8,PI3K-Akt signaling pathway; FoxO signaling pathway,Insulin Signaling,Stimuli-sensing channels,6,High,1
Q5VVQ6,Ubiquitin thioesterase OTU1 OS=Homo sapiens OX=9606 GN=YOD1 PE=1 SV=1,0.008,4.162,4,1,3,1,348,38.3,6.11,948,,1,,cell communication;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;protein binding,Pf02338,55432,ENSG00000180667.10,YOD1,1,Protein processing in endoplasmic reticulum,,Ovarian tumor domain proteases,5,High,1
Q9NV88,Integrator complex subunit 9 OS=Homo sapiens OX=9606 GN=INTS9 PE=1 SV=2,0.008,4.159,2,1,2,1,658,73.8,6.33,645,,1,,metabolic process,cytosol;nucleus,protein binding,Pf10996,55756,ENSG00000104299.14,INTS9,8,,,RNA polymerase II transcribes snRNA genes,3,High,1
Q96Q83,Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 OS=Homo sapiens OX=9606 GN=ALKBH3 PE=1 SV=1,0.008,4.156,7,2,3,2,286,33.4,8.4,779,,2,,cell proliferation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;mitochondrion;nucleus,catalytic activity;metal ion binding;protein binding,Pf13532,221120,ENSG00000166199.12,ALKBH3,11,,,ALKBH3 mediated reversal of alkylation damage,4,High,1
Q8N5R6,Coiled-coil domain-containing protein 33 OS=Homo sapiens OX=9606 GN=CCDC33 PE=1 SV=3,0.008,4.154,1,1,7,1,958,107.1,6.77,2865,,1,,,,protein binding,Pf00168,80125,,CCDC33,15,,,,0,High,1
P14384,Carboxypeptidase M OS=Homo sapiens OX=9606 GN=CPM PE=1 SV=2,0.008,4.144,4,1,3,1,443,50.5,7.36,700,,1,,metabolic process,cell surface;extracellular;membrane,catalytic activity;metal ion binding,"Pf00246, Pf00775, Pf04952, Pf13620, Pf13715",1368,ENSG00000135678.11,CPM,12,,,Post-translational modification: synthesis of GPI-anchored proteins,3,High,1
Q9UBY8,Protein CLN8 OS=Homo sapiens OX=9606 GN=CLN8 PE=1 SV=3,0.008,4.142,3,1,1,1,286,32.8,8.21,532,,1,,metabolic process;regulation of biological process;transport,endoplasmic reticulum;membrane,,Pf03798,2055,ENSG00000182372.9; ENSG00000278220.2,CLN8,8; CHR_HSCHR8_7_CTG1,,Synaptic Vesicle Pathway,,1,High,1
Q4VCS5,Angiomotin OS=Homo sapiens OX=9606 GN=AMOT PE=1 SV=1,0.008,4.135,2,2,3,2,1084,118,7.64,1158,,2,,cell differentiation;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cell surface;cytoplasm;cytosol,protein binding;receptor activity,Pf12240,154796,ENSG00000126016.15,AMOT,X,Hippo signaling pathway,VEGFA-VEGFR2 Signaling Pathway,Signaling by Hippo,4,High,1
P82970,High mobility group nucleosome-binding domain-containing protein 5 OS=Homo sapiens OX=9606 GN=HMGN5 PE=1 SV=1,0.008,4.134,5,1,14,1,282,31.5,4.55,4152,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,chromosome;nucleus,DNA binding;protein binding;RNA binding,Pf01101,79366,ENSG00000198157.10,HMGN5,X,,,,0,High,1
P16383,GC-rich sequence DNA-binding factor 2 OS=Homo sapiens OX=9606 GN=GCFC2 PE=1 SV=2,0.008,4.131,3,2,3,2,781,89.3,5.99,590,,2,,cell organization and biogenesis;metabolic process;regulation of biological process,cytosol;nucleus;spliceosomal complex,DNA binding;protein binding,Pf07842,6936,ENSG00000005436.13,GCFC2,2,,,mRNA Splicing - Major Pathway,4,High,1
P22670,MHC class II regulatory factor RFX1 OS=Homo sapiens OX=9606 GN=RFX1 PE=1 SV=2,0.008,4.13,1,1,3,1,979,104.7,6.29,941,,1,,metabolic process;regulation of biological process;response to stimulus,nucleus,DNA binding;protein binding,"Pf02257, Pf04589, Pf09770",5989,ENSG00000132005.8,RFX1,19,,,,0,High,1
Q9UPY3,Endoribonuclease Dicer OS=Homo sapiens OX=9606 GN=DICER1 PE=1 SV=3,0.008,4.129,1,2,3,2,1922,218.5,5.68,951,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding,"Pf00270, Pf00271, Pf00636, Pf02170, Pf03368, Pf04851, Pf14622",23405,ENSG00000100697.14,DICER1,14,MicroRNAs in cancer,miRNA Biogenesis; RNA interference; Hypoxia-mediated EMT and Stemness; mRNA Processing,MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis,9,High,1
O43567,E3 ubiquitin-protein ligase RNF13 OS=Homo sapiens OX=9606 GN=RNF13 PE=1 SV=1,0.008,4.126,6,1,3,1,381,42.8,4.98,1128,,1,,metabolic process,cytosol;endoplasmic reticulum;endosome;Golgi;membrane;nucleus;vacuole,catalytic activity;metal ion binding;protein binding,"Pf00097, Pf00628, Pf02225, Pf12678, Pf12861, Pf13639, Pf13920, Pf13923, Pf14634",11342,ENSG00000082996.19,RNF13,3,,,,0,High,1
Q9H1X3,DnaJ homolog subfamily C member 25 OS=Homo sapiens OX=9606 GN=DNAJC25 PE=1 SV=1,0.008,4.123,3,1,1,1,360,42.4,9.13,498,,1,,,membrane,,Pf00226,548645; 552891,ENSG00000059769.19,DNAJC25; DNAJC25-GNG10,9,,,,0,High,1
Q9UGU0,Transcription factor 20 OS=Homo sapiens OX=9606 GN=TCF20 PE=1 SV=3,0.008,4.121,1,2,10,2,1960,211.6,9.04,2622,,2,,metabolic process;regulation of biological process,nucleus,DNA binding;metal ion binding;RNA binding,"Pf13771, Pf13832",6942,ENSG00000280467.2; ENSG00000281897.2; ENSG00000283026.1; ENSG00000282892.1; ENSG00000283681.1; ENSG00000262024.6; ENSG00000100207.18; ENSG00000276461.4,TCF20,22; CHR_HSCHR22_4_CTG1; CHR_HSCHR22_5_CTG1; CHR_HSCHR22_6_CTG1; CHR_HSCHR22_7_CTG1; CHR_HSCHR22_8_CTG1; CHR_HSCHR22_1_CTG1; CHR_HSCHR22_3_CTG1,,Matrix Metalloproteinases,,1,High,1
P20701,Integrin alpha-L OS=Homo sapiens OX=9606 GN=ITGAL PE=1 SV=3,0.008,4.119,1,2,16,2,1170,128.7,5.63,6251,,2,,cell organization and biogenesis;cellular component movement;defense response;regulation of biological process;response to stimulus;transport,cell surface;membrane,metal ion binding;protein binding;receptor activity;signal transducer activity,"Pf00092, Pf01839, Pf08441, Pf13517, Pf13519",3683,ENSG00000005844.17,ITGAL,16,Rheumatoid arthritis; Regulation of actin cytoskeleton; Rap1 signaling pathway; Viral myocarditis; HTLV-I infection; Cell adhesion molecules (CAMs); Staphylococcus aureus infection; Epstein-Barr virus infection; Leukocyte transendothelial migration; Malaria; Natural killer cell mediated cytotoxicity,Integrin-mediated Cell Adhesion; Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,RUNX3 Regulates Immune Response and Cell Migration; Integrin cell surface interactions; Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall,28,High,1
Q96E09,Protein FAM122A OS=Homo sapiens OX=9606 GN=FAM122A PE=1 SV=1,0.008,4.116,4,1,1,1,287,30.5,6.79,494,,1,,,,protein binding,,116224,,FAM122A,9,,,,0,High,1
Q0VD83,Apolipoprotein B receptor OS=Homo sapiens OX=9606 GN=APOBR PE=1 SV=3,0.008,4.109,2,2,24,2,1097,115.6,4.4,5678,,2,,,,,,,,,,,,,0,High,1
Q9Y575,Ankyrin repeat and SOCS box protein 3 OS=Homo sapiens OX=9606 GN=ASB3 PE=1 SV=1,0.008,4.102,2,1,3,1,518,57.7,6.27,1234,,1,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,"Pf00023, Pf07525, Pf12796, Pf13606, Pf13637, Pf13857",51130; 100302652,ENSG00000115239.21,ASB3; GPR75-ASB3,2,,,Antigen processing: Ubiquitination & Proteasome degradation; Neddylation,7,High,1
P09105,Hemoglobin subunit theta-1 OS=Homo sapiens OX=9606 GN=HBQ1 PE=1 SV=2,0.008,4.101,6,1,2,1,142,15.5,7.62,1306,,1,,transport,,metal ion binding;protein binding;transporter activity,Pf00042,3049,ENSG00000086506.2,HBQ1,16,,,,0,High,1
Q5VTL8,Pre-mRNA-splicing factor 38B OS=Homo sapiens OX=9606 GN=PRPF38B PE=1 SV=1,0.008,4.1,3,2,2,2,546,64.4,10.54,635,,2,,metabolic process,nucleus;spliceosomal complex,RNA binding,Pf03371,55119,ENSG00000134186.11,PRPF38B,1,Spliceosome,,,1,High,1
Q14686,Nuclear receptor coactivator 6 OS=Homo sapiens OX=9606 GN=NCOA6 PE=1 SV=3,0.008,4.094,1,2,79,2,2063,219,9.36,20223,,2,,cell differentiation;metabolic process;regulation of biological process;response to stimulus,cytosol;nucleus,protein binding,"Pf09606, Pf09770, Pf13820, Pf15402",23054,ENSG00000198646.13,NCOA6,20,,Constitutive Androstane Receptor Pathway,"Transcriptional regulation of white adipocyte differentiation; Activation of gene expression by SREBF (SREBP); YAP1- and WWTR1 (TAZ)-stimulated gene expression; Transcriptional activation of mitochondrial biogenesis; RORA activates gene expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PPARA activates gene expression; BMAL1:CLOCK,NPAS2 activates circadian gene expression; RUNX3 regulates YAP1-mediated transcription",24,High,1
P78549,Endonuclease III-like protein 1 OS=Homo sapiens OX=9606 GN=NTHL1 PE=1 SV=2,0.008,4.086,3,1,5,1,312,34.4,9.67,1863,,1,,metabolic process;response to stimulus,mitochondrion;nucleus,catalytic activity;DNA binding;metal ion binding;protein binding,"Pf00633, Pf00730",4913,ENSG00000065057.7,NTHL1,16,Base excision repair,,Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Displacement of DNA glycosylase by APEX1,9,High,1
Q9HCD6,Protein TANC2 OS=Homo sapiens OX=9606 GN=TANC2 PE=1 SV=3,0.008,4.082,0,1,5,1,1990,219.5,8.07,1835,,1,,,,protein binding,"Pf00023, Pf12796, Pf13414, Pf13424, Pf13606, Pf13637, Pf13857",26115,ENSG00000170921.15,TANC2,17,,,,0,High,1
Q9NTU7,Cerebellin-4 OS=Homo sapiens OX=9606 GN=CBLN4 PE=1 SV=1,0.008,4.082,3,1,19,1,201,21.8,8.73,8699,,1,,transport,extracellular,protein binding,Pf00386,140689,ENSG00000054803.3,CBLN4,20,,,,0,High,1
A6NKF1,SAC3 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SAC3D1 PE=1 SV=2,0.008,4.079,3,1,2,1,404,43.5,8.69,656,,1,,cell division,cytoplasm;cytoskeleton,protein binding,Pf03399,29901,,SAC3D1,11,,,,0,High,1
Q8NHV4,Protein NEDD1 OS=Homo sapiens OX=9606 GN=NEDD1 PE=1 SV=1,0.008,4.076,3,1,1,1,660,71.9,7.97,265,,1,,cell division;regulation of biological process,cytoplasm;cytoskeleton;cytosol,protein binding,"Pf00400, Pf02239",121441,ENSG00000139350.11,NEDD1,12,,,Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes,16,High,1
O00458,Interferon-related developmental regulator 1 OS=Homo sapiens OX=9606 GN=IFRD1 PE=1 SV=4,0.008,4.073,2,1,8,1,451,50.2,7.18,3426,,1,,cell differentiation;development;regulation of biological process,cytoplasm;nucleus,,"Pf04836, Pf05004",3475,ENSG00000006652.13,IFRD1,7,,Hypertrophy Model,,1,High,1
Q8N386,Leucine-rich repeat-containing protein 25 OS=Homo sapiens OX=9606 GN=LRRC25 PE=1 SV=2,0.008,4.064,4,1,2,1,305,33.2,5.05,743,,1,,,membrane,protein binding,"Pf12799, Pf13855",126364,ENSG00000175489.9,LRRC25,19,,,,0,High,1
Q9NYR9,NF-kappa-B inhibitor-interacting Ras-like protein 2 OS=Homo sapiens OX=9606 GN=NKIRAS2 PE=1 SV=1,0.009,4.03,6,1,1,1,191,21.5,8.05,431,,1,,regulation of biological process;response to stimulus,cytoplasm;membrane,catalytic activity;nucleotide binding,"Pf00071, Pf08477",28511,ENSG00000168256.17,NKIRAS2,17,,,TRAF6 mediated NF-kB activation; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; RIP-mediated NFkB activation via ZBP1; Activated TLR4 signalling; Interleukin-1 family signaling,28,High,1
Q96I36,Cytochrome c oxidase assembly protein COX14 OS=Homo sapiens OX=9606 GN=COX14 PE=1 SV=1,0.009,4.03,14,1,9,1,57,6.6,9.55,2814,,1,,cell organization and biogenesis,membrane;mitochondrion,,Pf14880,84987,ENSG00000178449.8,COX14,12,,,TP53 Regulates Metabolic Genes; Respiratory electron transport,9,High,1
Q9UGN5,Poly [ADP-ribose] polymerase 2 OS=Homo sapiens OX=9606 GN=PARP2 PE=1 SV=2,0.009,4.026,1,1,344,1,583,66.2,8.88,146212,,1,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,catalytic activity;DNA binding;protein binding,"Pf00644, Pf02877, Pf05406",10038,ENSG00000129484.13,PARP2,14,Apoptosis; Base excision repair,NAD+ biosynthetic pathways,Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; POLB-Dependent Long Patch Base Excision Repair; HDR through MMEJ (alt-NHEJ); Dual Incision in GG-NER,16,High,1
Q9H875,PRKR-interacting protein 1 OS=Homo sapiens OX=9606 GN=PRKRIP1 PE=1 SV=1,0.009,4.025,8,2,6,2,184,21,9.79,2326,,2,,metabolic process;regulation of biological process,nucleus,enzyme regulator activity;protein binding;RNA binding,Pf06658,79706,ENSG00000128563.13,PRKRIP1,7,,,,0,High,1
Q6UWI2,Prostate androgen-regulated mucin-like protein 1 OS=Homo sapiens OX=9606 GN=PARM1 PE=1 SV=1,0.009,4.022,7,1,3,1,310,32.3,4.68,1320,,1,,regulation of biological process,cytosol;endosome;Golgi;membrane;nucleus,,,25849,ENSG00000169116.11,PARM1,4,,,,0,High,1
Q96JE9,Microtubule-associated protein 6 OS=Homo sapiens OX=9606 GN=MAP6 PE=1 SV=2,0.009,4.019,2,1,1,1,813,86.5,9.16,465,,1,,cell organization and biogenesis;transport,cytoplasm;cytoskeleton;Golgi,protein binding,"Pf05217, Pf05297",4135,ENSG00000171533.11,MAP6,11,,,,0,High,1
O60930,Ribonuclease H1 OS=Homo sapiens OX=9606 GN=RNASEH1 PE=1 SV=2,0.009,4.017,3,1,3,1,286,32,9.16,1297,,1,,metabolic process,cytoplasm;nucleus,catalytic activity;metal ion binding;RNA binding,"Pf00075, Pf01693",246243,ENSG00000171865.9,RNASEH1,2,DNA replication,,,1,High,1
Q9H3J6,"Probable peptide chain release factor C12orf65, mitochondrial OS=Homo sapiens OX=9606 GN=C12orf65 PE=2 SV=1",0.009,4.017,5,1,2,1,166,18.8,9.8,739,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,mitochondrion,catalytic activity;RNA binding,Pf00472,91574,ENSG00000130921.7,C12orf65,12,,,,0,High,1
Q13938,Calcyphosin OS=Homo sapiens OX=9606 GN=CAPS PE=1 SV=2,0.009,4.014,4,1,2,1,275,30.2,6.04,889,,1,,,,,,,,,,,,,0,High,1
Q86X53,Glutamate-rich protein 1 OS=Homo sapiens OX=9606 GN=ERICH1 PE=1 SV=1,0.009,4.001,2,1,3,1,443,49,4.78,1820,,1,,,,,Pf04147,157697,ENSG00000104714.13,ERICH1,8,,,,0,High,1
Q86US8,Telomerase-binding protein EST1A OS=Homo sapiens OX=9606 GN=SMG6 PE=1 SV=2,0.009,3.997,1,1,2,1,1419,160.4,7.05,1153,,1,,metabolic process;regulation of biological process;transport,chromosome;cytoplasm;cytosol;nucleus,catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding,"Pf10373, Pf10374, Pf13638",23293,ENSG00000070366.13,SMG6,17,mRNA surveillance pathway,,Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC),4,High,1
Q6ZW13,Uncharacterized protein C16orf86 OS=Homo sapiens OX=9606 GN=C16orf86 PE=2 SV=2,0.009,3.997,5,1,3,1,317,33.5,5.38,1038,,1,,,,,,388284,ENSG00000159761.14,C16orf86,16,,,,0,High,1
P31512,Dimethylaniline monooxygenase [N-oxide-forming] 4 OS=Homo sapiens OX=9606 GN=FMO4 PE=1 SV=3,0.01,3.991,3,2,2,2,558,63.3,8.46,582,,2,,metabolic process,endoplasmic reticulum;membrane,catalytic activity;nucleotide binding,"Pf00743, Pf13434, Pf13450, Pf13454, Pf13738",2329,ENSG00000076258.9,FMO4,1,Drug metabolism - cytochrome P450,Catalytic cycle of mammalian Flavin-containing MonoOxygenases (FMOs); Metapathway biotransformation,,3,High,1
Q92633,Lysophosphatidic acid receptor 1 OS=Homo sapiens OX=9606 GN=LPAR1 PE=1 SV=3,0.01,3.985,2,1,4,1,364,41.1,8.53,1348,,1,,cell differentiation;cell organization and biogenesis;cellular component movement;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cell surface;cytoplasm;endosome;membrane,metal ion binding;protein binding;receptor activity;signal transducer activity,Pf00001,1902,ENSG00000198121.13,LPAR1,9,Gap junction; Rap1 signaling pathway; Pathways in cancer; Phospholipase D signaling pathway; PI3K-Akt signaling pathway; Neuroactive ligand-receptor interaction,Small Ligand GPCRs; Myometrial Relaxation and Contraction Pathways; NOTCH1 regulation of human endothelial cell calcification; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,Lysosphingolipid and LPA receptors; Gastrin-CREB signalling pathway via PKC and MAPK; G alpha (i) signalling events,19,High,1
O43312,Protein MTSS 1 OS=Homo sapiens OX=9606 GN=MTSS1 PE=1 SV=2,0.01,3.984,4,2,21,2,755,82.2,6.92,8035,,2,,cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton,protein binding,"Pf02205, Pf08397",9788,ENSG00000170873.18,MTSS1,8,,,,0,High,1
Q9Y6M5,Zinc transporter 1 OS=Homo sapiens OX=9606 GN=SLC30A1 PE=1 SV=3,0.01,3.98,2,1,1,1,507,55.3,6.48,612,,1,,cellular homeostasis;regulation of biological process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;Golgi;membrane,protein binding;transporter activity,Pf01545,7779,ENSG00000170385.9,SLC30A1,1,Mineral absorption,Zinc homeostasis,Zinc efflux and compartmentalization by the SLC30 family,8,High,1
Q629K1,Triple QxxK/R motif-containing protein OS=Homo sapiens OX=9606 GN=TRIQK PE=3 SV=1,0.01,3.978,8,1,7,1,86,9.7,9.36,3332,,1,,,endoplasmic reticulum;membrane,,Pf15168,286144,ENSG00000205133.11,TRIQK,8,,,,0,High,1
Q6UB99,Ankyrin repeat domain-containing protein 11 OS=Homo sapiens OX=9606 GN=ANKRD11 PE=1 SV=3,0.01,3.973,1,1,31,1,2663,297.7,7.11,12598,,1,,,cytosol;membrane;nucleus,protein binding,"Pf00023, Pf12796, Pf13606, Pf13637, Pf13857",29123,ENSG00000167522.14,ANKRD11,16,,,,0,High,1
P11226,Mannose-binding protein C OS=Homo sapiens OX=9606 GN=MBL2 PE=1 SV=2,0.01,3.961,3,1,2,1,248,26.1,5.49,376,0,1,1,defense response;metabolic process;regulation of biological process;response to stimulus,cell surface;extracellular,catalytic activity;metal ion binding;protein binding,Pf00059,4153,ENSG00000165471.6,MBL2,10,Complement and coagulation cascades; Staphylococcus aureus infection; Phagosome,Regulation of toll-like receptor signaling pathway,Lectin pathway of complement activation,10,High,1
Q9BSG0,Protease-associated domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PRADC1 PE=1 SV=1,0.01,3.951,6,1,6,1,188,21,5.47,2222,,1,,,extracellular,protein binding,Pf02225,84279,ENSG00000135617.3,PRADC1,2,,,,0,High,1
Q15139,Serine/threonine-protein kinase D1 OS=Homo sapiens OX=9606 GN=PRKD1 PE=1 SV=2,0.01,3.95,3,2,2,1,912,101.6,6.62,524,,2,,cell communication;cell death;cell differentiation;cell organization and biogenesis;cell proliferation;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;Golgi;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf00130, Pf00169, Pf07714, Pf14531",5587,ENSG00000184304.14,PRKD1,14,Rap1 signaling pathway; Aldosterone synthesis and secretion,Apoptosis Modulation and Signaling; miRs in Muscle Cell Differentiation; Cardiac Hypertrophic Response; Myometrial Relaxation and Contraction Pathways; G Protein Signaling Pathways; VEGFA-VEGFR2 Signaling Pathway; Wnt Signaling Pathway and Pluripotency; Wnt Signaling Pathway; Calcium Regulation in the Cardiac Cell,Sphingolipid de novo biosynthesis,15,High,1
Q19T08,Endothelial cell-specific chemotaxis regulator OS=Homo sapiens OX=9606 GN=ECSCR PE=1 SV=1,0.01,3.949,4,1,6,1,205,21.3,7.88,1991,0,1,1,cell death;cell differentiation;development;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,protein binding,,641700,ENSG00000249751.3; ENSG00000279686.1,ECSCR,5,,,,0,High,1
Q9NW82,WD repeat-containing protein 70 OS=Homo sapiens OX=9606 GN=WDR70 PE=1 SV=1,0.01,3.945,4,2,2,2,654,73.2,6.33,510,,2,,,,protein binding,Pf00400,55100,ENSG00000082068.8,WDR70,5,,,,0,High,1
P45381,Aspartoacylase OS=Homo sapiens OX=9606 GN=ASPA PE=1 SV=1,0.01,3.944,3,1,2,1,313,35.7,6.52,605,,1,,metabolic process;regulation of biological process,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;protein binding,Pf04952,443,ENSG00000108381.10,ASPA,17,"Alanine, aspartate and glutamate metabolism; Histidine metabolism; Metabolic pathways",Alanine and aspartate metabolism,Amino acid synthesis and interconversion (transamination),7,High,1
Q86VI4,Lysosomal-associated transmembrane protein 4B OS=Homo sapiens OX=9606 GN=LAPTM4B PE=1 SV=2,0.01,3.943,2,1,6,1,317,35.1,8.75,2700,,1,,,,,,,,,,,,,0,High,1
Q92766,Ras-responsive element-binding protein 1 OS=Homo sapiens OX=9606 GN=RREB1 PE=1 SV=3,0.01,3.937,1,1,1,1,1687,181.3,6.98,470,,1,,development;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,DNA binding;metal ion binding,"Pf00096, Pf13465",6239,ENSG00000124782.19,RREB1,6,,,,0,High,1
Q8IVW6,AT-rich interactive domain-containing protein 3B OS=Homo sapiens OX=9606 GN=ARID3B PE=1 SV=2,0.01,3.937,2,2,6,1,561,60.6,7.52,2105,,2,,metabolic process;regulation of biological process,nucleus,DNA binding;protein binding,Pf01388,10620,ENSG00000179361.17,ARID3B,15,,,,0,High,1
Q96LT7,Guanine nucleotide exchange C9orf72 OS=Homo sapiens OX=9606 GN=C9orf72 PE=1 SV=2,0.01,3.935,3,2,2,2,481,54.3,6.23,583,,2,,cell growth;cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;endosome;extracellular;membrane;nucleus;vacuole,protein binding,Pf15019,203228,ENSG00000147894.14,C9orf72,9,,Mesodermal Commitment Pathway,,1,High,1
O14681,Etoposide-induced protein 2.4 homolog OS=Homo sapiens OX=9606 GN=EI24 PE=1 SV=4,0.01,3.935,2,1,4,1,340,38.9,9.72,1891,,1,,cell communication;cell death;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;Golgi;membrane;nucleus,,Pf07264,9538,ENSG00000149547.14,EI24,11,p53 signaling pathway,,,1,High,1
Q8IVB5,LIX1-like protein OS=Homo sapiens OX=9606 GN=LIX1L PE=2 SV=1,0.01,3.933,2,1,2,1,337,36.5,8.56,711,,1,,cell organization and biogenesis,cytoplasm,,Pf14954,128077,ENSG00000271601.3,LIX1L; LOC101060547,1,,,,0,High,1
Q9UQR1,Zinc finger protein 148 OS=Homo sapiens OX=9606 GN=ZNF148 PE=1 SV=2,0.01,3.93,3,2,5,2,794,88.9,6.48,1402,,2,,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,Golgi;nucleus,DNA binding;metal ion binding;protein binding,"Pf00096, Pf13465",7707,ENSG00000163848.19,ZNF148,3,,,,0,High,1
Q9H0U9,Testis-specific Y-encoded-like protein 1 OS=Homo sapiens OX=9606 GN=TSPYL1 PE=1 SV=3,0.01,3.929,2,1,2,1,437,49.2,5.45,628,,1,,cell organization and biogenesis,nucleus,protein binding,Pf00956,7259,ENSG00000189241.6,TSPYL1,6,,Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,,1,High,1
Q86X40,Leucine-rich repeat-containing protein 28 OS=Homo sapiens OX=9606 GN=LRRC28 PE=2 SV=1,0.01,3.927,3,1,5,1,367,41.9,7.94,2134,,1,,regulation of biological process;response to stimulus,membrane,protein binding,"Pf12799, Pf13855, Pf14580",123355,ENSG00000168904.14,LRRC28,15,,,,0,High,1
Q86YN1,Dolichyldiphosphatase 1 OS=Homo sapiens OX=9606 GN=DOLPP1 PE=2 SV=1,0.01,3.923,5,1,5,1,238,27,9.44,2059,,1,,metabolic process,endoplasmic reticulum;membrane,catalytic activity,Pf01569,57171,ENSG00000167130.17,DOLPP1,9,N-Glycan biosynthesis,,Synthesis of Dolichyl-phosphate,7,High,1
Q9UQB8,Brain-specific angiogenesis inhibitor 1-associated protein 2 OS=Homo sapiens OX=9606 GN=BAIAP2 PE=1 SV=1,0.01,3.922,2,1,1,1,552,60.8,8.9,537,,1,,cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;Golgi;membrane,protein binding,"Pf00018, Pf07653, Pf08397, Pf14604",10458,ENSG00000175866.15,BAIAP2,17,Regulation of actin cytoskeleton; Adherens junction,Regulation of Actin Cytoskeleton,Regulation of actin dynamics for phagocytic cup formation; VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs,14,High,1
Q9BZH6,WD repeat-containing protein 11 OS=Homo sapiens OX=9606 GN=WDR11 PE=1 SV=1,0.01,3.921,2,2,7,2,1224,136.6,6.92,910,,2,,,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,protein binding,,55717,ENSG00000120008.15,WDR11,10,,,,0,High,1
Q5VV41,Rho guanine nucleotide exchange factor 16 OS=Homo sapiens OX=9606 GN=ARHGEF16 PE=1 SV=1,0.01,3.917,3,2,5,2,709,80.1,7.36,1125,,2,,cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytosol,protein binding,"Pf00169, Pf00621",27237,ENSG00000130762.14,ARHGEF16,1,,,G alpha (12/13) signalling events; NRAGE signals death through JNK; Signalling by NGF; Rho GTPase cycle,11,High,1
P50443,Sulfate transporter OS=Homo sapiens OX=9606 GN=SLC26A2 PE=1 SV=2,0.01,3.909,1,1,6,1,739,81.6,8.38,2399,,1,,cellular homeostasis;metabolic process;transport,membrane,transporter activity,"Pf00916, Pf01740, Pf13792",1836,ENSG00000155850.7,SLC26A2,5,,,Defective SLC26A2 causes chondrodysplasias; Transport and synthesis of PAPS; Multifunctional anion exchangers,17,High,1
P25208,Nuclear transcription factor Y subunit beta OS=Homo sapiens OX=9606 GN=NFYB PE=1 SV=2,0.01,3.904,6,1,3,1,207,22.8,4.59,1392,,1,,metabolic process;regulation of biological process,nucleus,DNA binding;protein binding,"Pf00125, Pf00808",4801,ENSG00000120837.7,NFYB,12,HTLV-I infection; Tuberculosis; Antigen processing and presentation,,ATF4 activates genes; ATF6 (ATF6-alpha) activates chaperone genes; PPARA activates gene expression; Activation of gene expression by SREBF (SREBP),16,High,1
Q13395,Probable methyltransferase TARBP1 OS=Homo sapiens OX=9606 GN=TARBP1 PE=1 SV=1,0.01,3.903,2,2,2,2,1621,181.6,7.05,591,,2,,metabolic process;regulation of biological process,nucleus,catalytic activity;RNA binding,Pf00588,6894,ENSG00000059588.9,TARBP1,1,,,,0,High,1
Q5JTD0,Tight junction-associated protein 1 OS=Homo sapiens OX=9606 GN=TJAP1 PE=1 SV=1,0.01,3.898,2,1,3,1,557,61.8,5.97,1199,,1,,cell organization and biogenesis,cytoplasm;endosome;Golgi;membrane,protein binding,Pf15453,93643,ENSG00000137221.14,TJAP1,6,Tight junction,,,1,High,1
Q9Y6J0,Calcineurin-binding protein cabin-1 OS=Homo sapiens OX=9606 GN=CABIN1 PE=1 SV=1,0.01,3.893,1,1,5,1,2220,246.2,6.02,1755,,1,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytosol;nucleus,enzyme regulator activity;protein binding,"Pf09047, Pf13414",23523,ENSG00000099991.17,CABIN1,22,,,Formation of Senescence-Associated Heterochromatin Foci (SAHF),5,High,1
P20851,C4b-binding protein beta chain OS=Homo sapiens OX=9606 GN=C4BPB PE=1 SV=1,0.01,3.893,4,1,4,1,252,28.3,5.14,1521,,1,,coagulation;defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane,protein binding,Pf00084,725,ENSG00000123843.12,C4BPB,1,Complement and coagulation cascades; Pertussis,,Regulation of Complement cascade,6,High,1
Q86TM6,E3 ubiquitin-protein ligase synoviolin OS=Homo sapiens OX=9606 GN=SYVN1 PE=1 SV=2,0.01,3.89,1,1,5,1,617,67.6,6.95,2359,,1,,metabolic process;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;membrane,catalytic activity;metal ion binding;protein binding,"Pf00097, Pf12678, Pf12861, Pf12906, Pf13445, Pf13639, Pf13920, Pf13923, Pf14634",84447,ENSG00000162298.18,SYVN1,11,Protein processing in endoplasmic reticulum; Ubiquitin mediated proteolysis,,Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; ER Quality Control Compartment (ERQC); XBP1(S) activates chaperone genes; Hedgehog ligand biogenesis,18,High,1
Q9NUU6,Inactive ubiquitin thioesterase OTULINL OS=Homo sapiens OX=9606 GN=OTULINL PE=1 SV=1,0.01,3.882,2,1,3,1,356,42.2,9.29,1222,,1,,,,,,54491,ENSG00000145569.5,FAM105A,5,,,,0,High,1
Q8N4B1,Sesquipedalian-1 OS=Homo sapiens OX=9606 GN=PHETA1 PE=1 SV=1,0.01,3.881,4,1,2,1,249,27.2,8.98,969,,1,,cell organization and biogenesis;metabolic process;transport,cytosol;endosome;Golgi,protein binding,"Pf00169, Pf15413",144717,ENSG00000198324.13,FAM109A,12,,,,0,High,1
Q6N063,2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=OGFOD2 PE=2 SV=2,0.01,3.877,2,1,10,1,350,39,5.68,3039,,1,,metabolic process,,catalytic activity;metal ion binding,Pf03171,79676,ENSG00000111325.16,OGFOD2,12,,,,0,High,1
Q9H3H5,UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase OS=Homo sapiens OX=9606 GN=DPAGT1 PE=1 SV=2,0.01,3.877,3,1,7,1,408,46.1,8,2303,,1,,cell organization and biogenesis;metabolic process,endoplasmic reticulum;membrane,catalytic activity,Pf00953,1798,ENSG00000172269.18,DPAGT1,11,N-Glycan biosynthesis; Metabolic pathways,,"Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2; Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein",10,High,1
Q96BI3,Gamma-secretase subunit APH-1A OS=Homo sapiens OX=9606 GN=APH1A PE=1 SV=1,0.01,3.874,5,1,7,1,265,29,7.9,2269,,1,,metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;Golgi;membrane,catalytic activity;protein binding,Pf06105,51107,ENSG00000117362.12,APH1A,1,Notch signaling pathway; Alzheimer's disease,Alzheimers Disease; Notch Signaling Pathway; Notch Signaling Pathway,Activated NOTCH1 Transmits Signal to the Nucleus; Signaling by NOTCH4; Regulated proteolysis of p75NTR; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NRIF signals cell death from the nucleus; Signaling by NOTCH3; EPH-ephrin mediated repulsion of cells; NOTCH2 Activation and Transmission of Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Nuclear signaling by ERBB4; Signalling by NGF,32,High,1
P07992,DNA excision repair protein ERCC-1 OS=Homo sapiens OX=9606 GN=ERCC1 PE=1 SV=1,0.01,3.871,4,1,3,1,297,32.5,6.25,883,,1,,cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;DNA binding;protein binding,"Pf00633, Pf03834, Pf12826, Pf14520",2067,ENSG00000012061.15,ERCC1,19,Platinum drug resistance; Nucleotide excision repair; Fanconi anemia pathway,,Dual incision in TC-NER; HDR through Single Strand Annealing (SSA); Formation of Incision Complex in GG-NER; Dual Incision in GG-NER; Fanconi Anemia Pathway,15,High,1
P37268,Squalene synthase OS=Homo sapiens OX=9606 GN=FDFT1 PE=1 SV=1,0.01,3.868,4,1,3,1,417,48.1,6.54,1228,,1,,metabolic process;regulation of biological process,endoplasmic reticulum;membrane,catalytic activity;protein binding,Pf00494,2222,ENSG00000079459.12,FDFT1,8,Metabolic pathways; Steroid biosynthesis,Cholesterol Biosynthesis; Sterol Regulatory Element-Binding Proteins (SREBP) signalling; Statin Pathway,Cholesterol biosynthesis; PPARA activates gene expression; Activation of gene expression by SREBF (SREBP),13,High,1
Q9Y5U2,Protein TSSC4 OS=Homo sapiens OX=9606 GN=TSSC4 PE=1 SV=3,0.01,3.866,6,2,5,2,329,34.3,5.19,1270,,2,,,,protein binding,Pf15264,10078,ENSG00000184281.14,TSSC4,11,,,,0,High,1
Q9H992,E3 ubiquitin-protein ligase MARCH7 OS=Homo sapiens OX=9606 GN=MARCH7 PE=1 SV=1,0.01,3.866,2,1,2,1,704,78,6.77,834,,1,,metabolic process;regulation of biological process,,catalytic activity;metal ion binding,Pf12906,64844,ENSG00000136536.14,MARCH7,2,,,,0,High,1
A0A0B4J1Y8,Immunoglobulin lambda variable 9-49 OS=Homo sapiens OX=9606 GN=IGLV9-49 PE=1 SV=1,0.01,3.864,8,1,3,1,123,13,7.28,1104,,1,,response to stimulus,extracellular;membrane,protein binding,"Pf07679, Pf07686, Pf13895, Pf13927",28773,ENSG00000223350.2,IGLV9-49,22,,,,0,High,1
Q9BQJ4,Transmembrane protein 47 OS=Homo sapiens OX=9606 GN=TMEM47 PE=1 SV=1,0.01,3.862,4,1,2,1,181,20,6.73,641,,1,,,membrane,,Pf13903,83604,ENSG00000147027.3,TMEM47,X,,,,0,High,1
P09601,Heme oxygenase 1 OS=Homo sapiens OX=9606 GN=HMOX1 PE=1 SV=1,0.01,3.862,5,1,2,1,288,32.8,8.25,426,,1,,cell communication;cell death;cell organization and biogenesis;cell proliferation;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cytosol;endoplasmic reticulum;membrane;nucleus,catalytic activity;metal ion binding;protein binding;signal transducer activity,Pf01126,3162,ENSG00000100292.16,HMOX1,22,Mineral absorption; HIF-1 signaling pathway; Porphyrin and chlorophyll metabolism; MicroRNAs in cancer,NRF2 pathway; Transcriptional activation by NRF2; Overview of nanoparticle effects; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Lung fibrosis; Oxidative Stress,Interleukin-4 and 13 signaling; Heme degradation; Iron uptake and transport,19,High,1
Q07507,Dermatopontin OS=Homo sapiens OX=9606 GN=DPT PE=1 SV=2,0.01,3.861,5,1,6,1,201,24,4.82,1598,,1,,cell organization and biogenesis;regulation of biological process,extracellular,,Pf14704,1805,ENSG00000143196.4,DPT,1,,,,0,High,1
Q8TAC2,Josephin-2 OS=Homo sapiens OX=9606 GN=JOSD2 PE=1 SV=1,0.01,3.858,3,1,83,1,188,20.7,7.42,29644,,1,,metabolic process,cytoplasm;cytosol,catalytic activity,Pf02099,126119,ENSG00000161677.11,JOSD2,19,,,Josephin domain DUBs,4,High,1
Q8IVN8,Somatomedin-B and thrombospondin type-1 domain-containing protein OS=Homo sapiens OX=9606 GN=SBSPON PE=1 SV=2,0.01,3.855,2,1,11,1,264,29.6,7.5,4028,,1,,response to stimulus;transport,extracellular,receptor activity,,157869,ENSG00000164764.10,SBSPON,8,,,O-glycosylation of TSR domain-containing proteins; Defective B3GALTL causes Peters-plus syndrome (PpS),8,High,1
Q5TGY1,Transmembrane and coiled-coil domain-containing protein 4 OS=Homo sapiens OX=9606 GN=TMCO4 PE=2 SV=1,0.011,3.849,2,1,1,1,634,67.9,5.85,469,,1,,,membrane,,"Pf05277, Pf05990",255104,ENSG00000162542.13,TMCO4,1,,,,0,High,1
Q96GF1,E3 ubiquitin-protein ligase RNF185 OS=Homo sapiens OX=9606 GN=RNF185 PE=1 SV=1,0.011,3.846,4,1,3,1,192,20.4,6.52,1593,,1,,metabolic process;response to stimulus;transport,endoplasmic reticulum;membrane;mitochondrion,catalytic activity;metal ion binding;protein binding,"Pf00097, Pf12678, Pf12861, Pf13445, Pf13639, Pf13920, Pf13923, Pf14634, Pf15227",91445,ENSG00000138942.15,RNF185,22,Protein processing in endoplasmic reticulum,,ER Quality Control Compartment (ERQC); ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis,13,High,1
Q92540,Protein SMG7 OS=Homo sapiens OX=9606 GN=SMG7 PE=1 SV=2,0.011,3.846,1,2,7,2,1137,127.2,8.72,2284,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;nucleus,catalytic activity;DNA binding;protein binding;RNA binding,"Pf10373, Pf10374, Pf13414, Pf13424",9887,ENSG00000116698.21,SMG7,1,mRNA surveillance pathway,,Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC),4,High,1
Q5KU26,Collectin-12 OS=Homo sapiens OX=9606 GN=COLEC12 PE=1 SV=3,0.011,3.836,3,2,7,2,742,81.5,5.69,2360,,2,,cell organization and biogenesis;defense response;regulation of biological process;response to stimulus;transport,membrane,metal ion binding;receptor activity;signal transducer activity,"Pf00059, Pf13166",81035,ENSG00000158270.11,COLEC12,18,Phagosome,,Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Scavenging by Class A Receptors,7,High,1
P06133,UDP-glucuronosyltransferase 2B4 OS=Homo sapiens OX=9606 GN=UGT2B4 PE=1 SV=2,0.011,3.835,8,2,4,1,528,60.5,8.51,825,,2,,metabolic process,endoplasmic reticulum;membrane,catalytic activity,"Pf00201, Pf04101",7363,ENSG00000156096.13,UGT2B4,4,Drug metabolism - other enzymes; Drug metabolism - cytochrome P450; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions; Porphyrin and chlorophyll metabolism; Steroid hormone biosynthesis; Bile secretion; Metabolic pathways; Chemical carcinogenesis; Retinol metabolism; Metabolism of xenobiotics by cytochrome P450,Farnesoid X Receptor  Pathway; Glucuronidation; Metapathway biotransformation,Glucuronidation,18,High,1
Q9UNH5,Dual specificity protein phosphatase CDC14A OS=Homo sapiens OX=9606 GN=CDC14A PE=1 SV=1,0.011,3.834,2,1,2,1,594,66.5,9.1,879,,1,,cell division;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process,cytoplasm;cytoskeleton;cytosol;nucleus,catalytic activity;protein binding,"Pf00102, Pf00782, Pf03999, Pf14566, Pf14671",8556,ENSG00000079335.18,CDC14A,1,Cell cycle,Cell Cycle,Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; MAPK6/MAPK4 signaling,10,High,1
Q96QH2,PML-RARA-regulated adapter molecule 1 OS=Homo sapiens OX=9606 GN=PRAM1 PE=1 SV=3,0.011,3.834,3,2,9,2,670,73.9,9.67,2352,,2,,,,,,,,,,,,,0,High,1
O60232,Protein ZNRD2 OS=Homo sapiens OX=9606 GN=ZNRD2 PE=1 SV=1,0.011,3.832,18,2,2,2,199,21.5,5.24,435,,2,,cell division,,protein binding,Pf06677,10534,ENSG00000173465.7,SSSCA1,11,,,,0,High,1
Q99969,Retinoic acid receptor responder protein 2 OS=Homo sapiens OX=9606 GN=RARRES2 PE=1 SV=1,0.011,3.832,17,1,2,1,163,18.6,9.09,628,,1,,cell differentiation;defense response;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;organelle lumen,protein binding,,5919,ENSG00000106538.9,RARRES2,7,,,Platelet degranulation,4,High,1
Q9UJX5,Anaphase-promoting complex subunit 4 OS=Homo sapiens OX=9606 GN=ANAPC4 PE=1 SV=2,0.011,3.829,1,1,1,1,808,92.1,5.53,339,,1,,cell division;metabolic process;regulation of biological process,cytosol;nucleus,catalytic activity;protein binding,"Pf12894, Pf12896",29945,ENSG00000053900.10,ANAPC4,4,Ubiquitin mediated proteolysis; Oocyte meiosis; Progesterone-mediated oocyte maturation; Cell cycle; HTLV-I infection,,APC/C:Cdc20 mediated degradation of Cyclin B; Inactivation of APC/C via direct inhibition of the APC/C complex; Autodegradation of Cdh1 by Cdh1:APC/C; APC-Cdc20 mediated degradation of Nek2A; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Antigen processing: Ubiquitination & Proteasome degradation; Phosphorylation of the APC/C; APC/C:Cdc20 mediated degradation of Securin; Separation of Sister Chromatids; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Senescence-Associated Secretory Phenotype (SASP),37,High,1
Q5TKA1,Protein lin-9 homolog OS=Homo sapiens OX=9606 GN=LIN9 PE=1 SV=1,0.011,3.829,1,1,2,1,542,61.9,9.04,877,,1,,metabolic process;regulation of biological process,nucleus,protein binding,Pf06584,286826,,LIN9,1,,Gastric Cancer Network 1,Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; Cyclin E associated events during G1/S transition ; Polo-like kinase mediated events; Activation of E2F1 target genes at G1/S; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry,16,High,1
Q9NW07,Zinc finger protein 358 OS=Homo sapiens OX=9606 GN=ZNF358 PE=1 SV=2,0.011,3.818,2,1,2,1,568,59.3,6.6,613,,1,,metabolic process;regulation of biological process,nucleus,DNA binding;metal ion binding,"Pf00096, Pf13465",140467,ENSG00000198816.6,ZNF358,19,,,,0,High,1
Q99442,Translocation protein SEC62 OS=Homo sapiens OX=9606 GN=SEC62 PE=1 SV=1,0.011,3.807,2,1,6,1,399,45.8,7.12,2117,,1,,cell organization and biogenesis;transport,cytosol;endoplasmic reticulum;membrane,receptor activity;transporter activity,Pf03839,7095,ENSG00000008952.16,SEC62,3,Protein export; Protein processing in endoplasmic reticulum,,XBP1(S) activates chaperone genes,6,High,1
Q9HD67,Unconventional myosin-X OS=Homo sapiens OX=9606 GN=MYO10 PE=1 SV=3,0.011,3.804,0,1,6,1,2058,237.2,6.21,3490,,1,,regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane,catalytic activity;motor activity;nucleotide binding;protein binding,"Pf00063, Pf00169, Pf00373, Pf00769, Pf00784, Pf12325, Pf15409",4651,ENSG00000145555.14,MYO10,5,Fc gamma R-mediated phagocytosis,,Netrin-1 signaling; Regulation of actin dynamics for phagocytic cup formation,8,High,1
Q9H246,Uncharacterized protein C1orf21 OS=Homo sapiens OX=9606 GN=C1orf21 PE=1 SV=1,0.011,3.8,8,1,2,1,121,13.9,5.22,686,,1,,,,protein binding,Pf15389,81563,ENSG00000116667.12,C1orf21,1,,,,0,High,1
Q66GS9,Centrosomal protein of 135 kDa OS=Homo sapiens OX=9606 GN=CEP135 PE=1 SV=2,0.011,3.798,2,2,15,2,1140,133.4,6.21,4913,,2,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol,protein binding;transporter activity,"Pf01496, Pf02463, Pf04111, Pf05557, Pf07888, Pf10174, Pf12128",9662,ENSG00000174799.10,CEP135,4,,,Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes,16,High,1
A1Z1Q3,ADP-ribose glycohydrolase MACROD2 OS=Homo sapiens OX=9606 GN=MACROD2 PE=1 SV=2,0.011,3.795,6,1,2,1,425,47.4,4.68,963,,1,,,,,,,,,,,,,0,High,1
Q6ZVH6,Putative uncharacterized protein FLJ42569 OS=Homo sapiens OX=9606 PE=2 SV=1,0.011,3.784,17,1,10,1,145,15.8,7.99,4575,,1,,,,,,,,,,,,,0,High,1
P23025,DNA repair protein complementing XP-A cells OS=Homo sapiens OX=9606 GN=XPA PE=1 SV=1,0.011,3.781,9,1,4,1,273,31.3,6.73,1276,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,DNA binding;metal ion binding;protein binding,"Pf01286, Pf05181",7507,ENSG00000136936.10,XPA,9,Platinum drug resistance; Nucleotide excision repair,,Dual incision in TC-NER; Formation of TC-NER Pre-Incision Complex; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER,10,High,1
Q6UY14,ADAMTS-like protein 4 OS=Homo sapiens OX=9606 GN=ADAMTSL4 PE=1 SV=2,0.011,3.777,1,1,3,1,1074,116.5,8.34,1451,,1,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process,extracellular;organelle lumen,catalytic activity;protein binding,"Pf00090, Pf05986, Pf08686",54507,ENSG00000143382.14,ADAMTSL4,1,,,O-glycosylation of TSR domain-containing proteins; Defective B3GALTL causes Peters-plus syndrome (PpS),8,High,1
A6NEL2,Ankyrin repeat domain-containing protein SOWAHB OS=Homo sapiens OX=9606 GN=SOWAHB PE=1 SV=1,0.011,3.772,1,1,6,1,793,85.7,9.6,2095,,1,,,,protein binding,"Pf00023, Pf12796, Pf13606, Pf13637, Pf13857",345079,ENSG00000186212.3,SOWAHB,4,,,,0,High,1
P0DN79,Cystathionine beta-synthase-like protein OS=Homo sapiens OX=9606 GN=CBSL PE=1 SV=1,0.011,3.768,3,2,4,2,551,60.5,6.65,1386,,2,,cell communication;metabolic process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;protein binding,"Pf00291, Pf00571",875; 102724560,ENSG00000160200.17; ENSG00000274276.4,CBS; LOC102724560; CBSL,21,"Glycine, serine and threonine metabolism; Metabolic pathways; Biosynthesis of amino acids; Cysteine and methionine metabolism",Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate-Alcohol and Cancer Pathway; Folate Metabolism; Trans-sulfuration pathway; Trans-sulfuration and one carbon metabolism; Amino Acid metabolism; One carbon metabolism and related pathways,"Metabolism of ingested SeMet, Sec, MeSec into H2Se; Cysteine formation from homocysteine",18,High,1
Q15678,Tyrosine-protein phosphatase non-receptor type 14 OS=Homo sapiens OX=9606 GN=PTPN14 PE=1 SV=2,0.011,3.766,1,1,4,1,1187,135.2,8.31,1130,,1,,metabolic process;regulation of biological process,cytoplasm;cytoskeleton;nucleus,catalytic activity;protein binding,"Pf00102, Pf00373, Pf00782, Pf09379, Pf09380",5784,ENSG00000152104.11,PTPN14,1,,,,0,High,1
Q05315,Galectin-10 OS=Homo sapiens OX=9606 GN=CLC PE=1 SV=3,0.011,3.764,4,1,4,1,142,16.4,7.37,1682,,1,,cell death;development;regulation of biological process,cytoplasm;cytosol,catalytic activity;protein binding,Pf00337,1178,ENSG00000105205.6,CLC,19,,,,0,High,1
P01266,Thyroglobulin OS=Homo sapiens OX=9606 GN=TG PE=1 SV=5,0.011,3.763,1,1,2,1,2768,304.6,5.58,275,,1,,metabolic process;regulation of biological process;response to stimulus;transport,extracellular,catalytic activity;protein binding,"Pf00086, Pf00135, Pf07699, Pf07859",7038,ENSG00000042832.11,TG,8,Autoimmune thyroid disease; Thyroid hormone synthesis,Thyroxine (Thyroid Hormone) Production,,3,High,1
Q15223,Nectin-1 OS=Homo sapiens OX=9606 GN=NECTIN1 PE=1 SV=3,0.011,3.761,3,1,5,1,517,57.1,6.1,1784,,1,,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus;transport,extracellular;membrane,protein binding;receptor activity;signal transducer activity,"Pf00047, Pf07679, Pf07686, Pf08205, Pf13895, Pf13927",5818,ENSG00000110400.10,PVRL1; NECTIN1,11,Cell adhesion molecules (CAMs); Herpes simplex infection; Adherens junction,,Nectin/Necl  trans heterodimerization,8,High,1
Q9NVN8,Guanine nucleotide-binding protein-like 3-like protein OS=Homo sapiens OX=9606 GN=GNL3L PE=1 SV=1,0.011,3.761,3,1,4,1,582,65.5,8.44,1057,,1,,regulation of biological process,cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf01926, Pf02421, Pf11849",54552,ENSG00000130119.15,GNL3L,X,Ribosome biogenesis in eukaryotes,,,1,High,1
Q96E29,"Transcription termination factor 3, mitochondrial OS=Homo sapiens OX=9606 GN=MTERF3 PE=1 SV=2",0.011,3.758,2,1,3,1,417,47.9,8.53,791,,1,,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,membrane;mitochondrion,DNA binding;protein binding;RNA binding,Pf02536,51001,ENSG00000156469.8,MTERFD1; MTERF3,8,,Mitochondrial Gene Expression,Pink/Parkin Mediated Mitophagy,3,High,1
Q8NBJ9,SID1 transmembrane family member 2 OS=Homo sapiens OX=9606 GN=SIDT2 PE=1 SV=2,0.011,3.758,1,1,3,1,832,94.4,6.96,1351,,1,,cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus;transport,membrane;vacuole,DNA binding;protein binding;RNA binding;transporter activity,Pf13965,51092,ENSG00000149577.15,SIDT2,11,,,,0,High,1
Q68D10,Protein SPT2 homolog OS=Homo sapiens OX=9606 GN=SPTY2D1 PE=1 SV=3,0.011,3.755,1,1,8,1,685,75.6,9.79,4066,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,nucleus,DNA binding;protein binding,Pf08243,144108,ENSG00000179119.14,SPTY2D1,11,,,,0,High,1
Q08289,Voltage-dependent L-type calcium channel subunit beta-2 OS=Homo sapiens OX=9606 GN=CACNB2 PE=1 SV=3,0.011,3.749,2,1,6,1,660,73.5,8.1,,17.19,,1,cell communication;cell organization and biogenesis;regulation of biological process;transport,membrane,protein binding;transporter activity,"Pf00018, Pf00625",783,ENSG00000165995.18,CACNB2,10,Hypertrophic cardiomyopathy (HCM); Dilated cardiomyopathy; Adrenergic signaling in cardiomyocytes; MAPK signaling pathway; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Cardiac muscle contraction; Oxytocin signaling pathway,Arrhythmogenic Right Ventricular Cardiomyopathy,"Phase 2 - plateau phase; Adrenaline,noradrenaline inhibits insulin secretion; Phase 0 - rapid depolarisation; NCAM1 interactions; Presynaptic depolarization and calcium channel opening",23,High,1
Q92546,RAB6A-GEF complex partner protein 2 OS=Homo sapiens OX=9606 GN=RGP1 PE=1 SV=1,0.011,3.748,4,1,3,1,391,42.4,5.96,1301,,1,,regulation of biological process;transport,cytoplasm;cytosol;membrane,protein binding,Pf08737,9827,ENSG00000107185.9,RGP1,9,,,Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network; RAB GEFs exchange GTP for GDP on RABs,7,High,1
Q09472,Histone acetyltransferase p300 OS=Homo sapiens OX=9606 GN=EP300 PE=1 SV=2,0.011,3.747,1,1,4,1,2414,264,8.5,755,,1,,cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;cytosol;nucleus,catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding,"Pf00439, Pf00569, Pf02135, Pf02172, Pf06001, Pf08214, Pf09030, Pf09770",2033,ENSG00000100393.12,EP300,22,Glucagon signaling pathway; Long-term potentiation; MicroRNAs in cancer; Herpes simplex infection; TGF-beta signaling pathway; Wnt signaling pathway; Renal cell carcinoma; Pathways in cancer; Influenza A; HIF-1 signaling pathway; Adherens junction; HTLV-I infection; Epstein-Barr virus infection; Cell cycle; Tuberculosis; FoxO signaling pathway; Notch signaling pathway; Thyroid hormone signaling pathway; Hepatitis B; Jak-STAT signaling pathway; Prostate cancer; Viral carcinogenesis; Melanogenesis; Huntington's disease; cAMP signaling pathway,Androgen receptor signaling pathway; Energy Metabolism; Cell Cycle; Integrated Breast Cancer Pathway; Signaling Pathways in Glioblastoma; Aryl Hydrocarbon Receptor; Aryl Hydrocarbon Receptor Pathway; Kit receptor signaling pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Pathways Affected in Adenoid Cystic Carcinoma; Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex; TGF-beta Signaling Pathway; IL-4 Signaling Pathway; Wnt Signaling Pathway and Pluripotency; TGF-beta Receptor Signaling; Notch Signaling Pathway; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,"NOTCH1 Intracellular Domain Regulates Transcription; Transcriptional regulation of white adipocyte differentiation; TRAF6 mediated IRF7 activation; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; PPARA activates gene expression; Factors involved in megakaryocyte development and platelet production; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Formation of the beta-catenin:TCF transactivating complex; Pre-NOTCH Transcription and Translation; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Metalloprotease DUBs; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production; PI5P Regulates TP53 Acetylation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Gap-filling DNA repair synthesis and ligation in TC-NER; Polo-like kinase mediated events; RUNX3 regulates p14-ARF; RORA activates gene expression; Regulation of gene expression by Hypoxia-inducible Factor; HATs acetylate histones; Regulation of TP53 Activity through Methylation; Formation of TC-NER Pre-Incision Complex; TRAF3-dependent IRF activation pathway; CD209 (DC-SIGN) signaling; NOTCH2 intracellular domain regulates transcription; Activation of the TFAP2 (AP-2) family of transcription factors; Attenuation phase; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Regulation of RUNX3 expression and activity; RUNX3 regulates NOTCH signaling; Dual incision in TC-NER; B-WICH complex positively regulates rRNA expression",130,High,1
Q03701,CCAAT/enhancer-binding protein zeta OS=Homo sapiens OX=9606 GN=CEBPZ PE=1 SV=3,0.011,3.745,1,1,1,1,1054,120.9,5.94,418,,1,,metabolic process;regulation of biological process,nucleus,DNA binding;RNA binding,Pf03914,10153,ENSG00000115816.14,CEBPZ,2,,Gastric cancer network 2,,1,High,1
Q9H7E9,UPF0488 protein C8orf33 OS=Homo sapiens OX=9606 GN=C8orf33 PE=1 SV=1,0.011,3.743,9,2,6,2,229,25,9.95,2218,,2,,,,protein binding,Pf15393,65265,ENSG00000182307.12,C8orf33,8,,,,0,High,1
Q96JB3,Hypermethylated in cancer 2 protein OS=Homo sapiens OX=9606 GN=HIC2 PE=1 SV=2,0.011,3.742,1,1,16,1,615,66.1,6.38,6434,,1,,metabolic process;regulation of biological process,nucleus,DNA binding;metal ion binding;protein binding,"Pf00096, Pf00651, Pf13465",23119,ENSG00000169635.9,HIC2,22,,,,0,High,1
P54687,"Branched-chain-amino-acid aminotransferase, cytosolic OS=Homo sapiens OX=9606 GN=BCAT1 PE=1 SV=3",0.011,3.741,3,1,4,1,386,42.9,5.3,1634,,1,,cell proliferation;metabolic process,cytoplasm;cytosol;mitochondrion,catalytic activity;protein binding,Pf01063,586,ENSG00000060982.14,BCAT1,12,"Pantothenate and CoA biosynthesis; Metabolic pathways; Biosynthesis of amino acids; Valine, leucine and isoleucine degradation; 2-Oxocarboxylic acid metabolism; Cysteine and methionine metabolism; Valine, leucine and isoleucine biosynthesis",Amino Acid metabolism,Branched-chain amino acid catabolism,11,High,1
A6NMB1,Sialic acid-binding Ig-like lectin 16 OS=Homo sapiens OX=9606 GN=SIGLEC16 PE=2 SV=3,0.011,3.735,1,1,77,1,481,53,9.03,33372,,1,,defense response;response to stimulus,membrane,protein binding,"Pf00047, Pf07679, Pf08205, Pf13895, Pf13927",400709,,SIGLEC16,19,,,DAP12 interactions,3,High,1
P09917,Arachidonate 5-lipoxygenase OS=Homo sapiens OX=9606 GN=ALOX5 PE=1 SV=2,0.011,3.733,2,1,1,1,674,77.9,5.77,306,,1,,defense response;metabolic process;response to stimulus;transport,cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen,catalytic activity;metal ion binding;protein binding,"Pf00305, Pf01477",240,ENSG00000012779.10; ENSG00000275565.4,ALOX5,10; CHR_HSCHR10_1_CTG2,Ovarian steroidogenesis; Fc epsilon RI signaling pathway; Arachidonic acid metabolism; Serotonergic synapse; Metabolic pathways; Toxoplasmosis,Selenium Micronutrient Network; Eicosanoid Synthesis,Synthesis of Leukotrienes (LT) and Eoxins (EX); Neutrophil degranulation; Synthesis of Lipoxins (LX); Interleukin-18 signaling; Interleukin-4 and 13 signaling; Synthesis of 5-eicosatetraenoic acids,23,High,1
Q9Y4F9,Rho family-interacting cell polarization regulator 2 OS=Homo sapiens OX=9606 GN=RIPOR2 PE=1 SV=4,0.011,3.728,1,1,8,1,1068,118.4,5.41,4283,,1,,cell differentiation;development;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;membrane,protein binding,,9750,ENSG00000111913.17,FAM65B; RIPOR2,6,,,,0,High,1
Q8IZR5,CKLF-like MARVEL transmembrane domain-containing protein 4 OS=Homo sapiens OX=9606 GN=CMTM4 PE=1 SV=1,0.011,3.726,4,1,2,1,234,25.8,7.75,1087,,1,,regulation of biological process;response to stimulus,membrane,protein binding,Pf01284,146223,ENSG00000183723.12,CMTM4,16,,,,0,High,1
P51965,Ubiquitin-conjugating enzyme E2 E1 OS=Homo sapiens OX=9606 GN=UBE2E1 PE=1 SV=1,0.011,3.726,13,2,2,2,193,21.4,8.53,488,,2,,cell organization and biogenesis;metabolic process;regulation of biological process,cytosol;nucleus,catalytic activity;nucleotide binding;protein binding,Pf00179,7324,ENSG00000170142.11,UBE2E1,3,Ubiquitin mediated proteolysis,Photodynamic therapy-induced unfolded protein response,Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; ISG15 antiviral mechanism; Autodegradation of Cdh1 by Cdh1:APC/C; APC-Cdc20 mediated degradation of Nek2A; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Antigen processing: Ubiquitination & Proteasome degradation; Phosphorylation of the APC/C; APC/C:Cdc20 mediated degradation of Securin; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; E3 ubiquitin ligases ubiquitinate target proteins; Separation of Sister Chromatids; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Senescence-Associated Secretory Phenotype (SASP),43,High,1
Q7RTN6,STE20-related kinase adapter protein alpha OS=Homo sapiens OX=9606 GN=STRADA PE=1 SV=1,0.011,3.722,3,1,1,1,431,48.3,6.48,361,,1,,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus,catalytic activity;enzyme regulator activity;nucleotide binding;protein binding,"Pf00069, Pf07714",92335,ENSG00000266173.6,STRADA,17,mTOR signaling pathway; AMPK signaling pathway,AMP-activated Protein Kinase (AMPK) Signaling; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,Energy dependent regulation of mTOR by LKB1-AMPK,7,High,1
Q9Y5U9,Immediate early response 3-interacting protein 1 OS=Homo sapiens OX=9606 GN=IER3IP1 PE=1 SV=1,0.011,3.722,24,1,2,1,82,9,8.22,553,,1,,regulation of biological process;transport,endoplasmic reticulum;Golgi;membrane,,Pf08571,51124,ENSG00000267228.7; ENSG00000134049.5,IER3IP1,18,,,,0,High,1
P30273,High affinity immunoglobulin epsilon receptor subunit gamma OS=Homo sapiens OX=9606 GN=FCER1G PE=1 SV=1,0.011,3.722,13,1,1,1,86,9.7,7.12,363,,1,,cell differentiation;cell organization and biogenesis;cellular component movement;coagulation;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;membrane,protein binding;receptor activity;signal transducer activity,"Pf02189, Pf11628",2207,ENSG00000158869.10,FCER1G,1,Phospholipase D signaling pathway; Sphingolipid signaling pathway; Platelet activation; Natural killer cell mediated cytotoxicity; Asthma; Fc epsilon RI signaling pathway; Tuberculosis,Microglia Pathogen Phagocytosis Pathway,FCERI mediated Ca+2 mobilization; Neutrophil degranulation; GPVI-mediated activation cascade; Cell surface interactions at the vascular wall; Dectin-2 family; FCERI mediated MAPK activation; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated NF-kB activation; Platelet Adhesion to exposed collagen,23,High,1
Q8WVF1,Protein OSCP1 OS=Homo sapiens OX=9606 GN=OSCP1 PE=1 SV=4,0.011,3.715,5,2,5,2,389,44.6,5.83,2032,,2,,transport,membrane,,Pf10188,127700,ENSG00000116885.18,OSCP1,1,,,,0,High,1
Q96SB4,SRSF protein kinase 1 OS=Homo sapiens OX=9606 GN=SRPK1 PE=1 SV=2,0.011,3.714,2,1,1,1,655,74.3,6.16,361,,1,,cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding;RNA binding,"Pf00069, Pf07714",6732,ENSG00000096063.15,SRPK1,6,Herpes simplex infection,mRNA Processing,,2,High,1
Q9UBQ6,Exostosin-like 2 OS=Homo sapiens OX=9606 GN=EXTL2 PE=1 SV=1,0.011,3.714,6,1,2,1,330,37.4,8.95,638,,1,,metabolic process,endoplasmic reticulum;extracellular;membrane,catalytic activity;metal ion binding,Pf09258,2135,ENSG00000162694.13,EXTL2,1,Metabolic pathways; Glycosaminoglycan biosynthesis - heparan sulfate / heparin,,XBP1(S) activates chaperone genes,6,High,1
Q8TE73,"Dynein heavy chain 5, axonemal OS=Homo sapiens OX=9606 GN=DNAH5 PE=1 SV=3",0.011,3.71,0,1,6,1,4624,528.7,6.1,1917,,1,,cell organization and biogenesis;cellular component movement,cytoplasm;cytoskeleton,catalytic activity;motor activity;nucleotide binding;protein binding,"Pf03028, Pf07728, Pf08385, Pf08393, Pf12774, Pf12775, Pf12777, Pf12780, Pf12781",1767,ENSG00000039139.9,DNAH5,5,Huntington's disease,,,1,High,1
Q14520,Hyaluronan-binding protein 2 OS=Homo sapiens OX=9606 GN=HABP2 PE=1 SV=1,0.011,3.708,2,1,6,1,560,62.6,6.54,1989,,1,,metabolic process,extracellular,catalytic activity;metal ion binding,"Pf00051, Pf00089",3026,ENSG00000148702.14,HABP2,10,,,,0,High,1
Q9HAP6,Protein lin-7 homolog B OS=Homo sapiens OX=9606 GN=LIN7B PE=1 SV=1,0.011,3.706,5,1,7,1,207,22.9,8.66,3563,,1,,cell organization and biogenesis;transport,membrane,protein binding,"Pf00595, Pf02828, Pf09829, Pf13180",64130,ENSG00000104863.11,LIN7B,19,,,Dopamine Neurotransmitter Release Cycle; RHO GTPases Activate Rhotekin and Rhophilins; Neurexins and neuroligins,10,High,1
Q9H0G5,Nuclear speckle splicing regulatory protein 1 OS=Homo sapiens OX=9606 GN=NSRP1 PE=1 SV=1,0.012,3.699,4,2,23,2,558,66.4,8.84,8956,,2,,metabolic process;regulation of biological process;transport,nucleus,protein binding;RNA binding,Pf09745,84081,ENSG00000126653.17,NSRP1,17,,,,0,High,1
Q96BY9,Store-operated calcium entry-associated regulatory factor OS=Homo sapiens OX=9606 GN=SARAF PE=1 SV=1,0.012,3.699,4,1,5,1,339,37,7.58,1342,,1,,regulation of biological process;transport,endoplasmic reticulum;membrane,protein binding,Pf06682,51669,ENSG00000133872.13,TMEM66; SARAF,8,,,,0,High,1
O15162,Phospholipid scramblase 1 OS=Homo sapiens OX=9606 GN=PLSCR1 PE=1 SV=1,0.012,3.687,2,1,24,1,318,35,4.94,8701,,1,,cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,cytosol;Golgi;membrane;nucleus,DNA binding;metal ion binding;protein binding;transporter activity,Pf03803,5359,ENSG00000188313.12,PLSCR1,3,,EGF/EGFR Signaling Pathway,,1,High,1
Q01831,DNA repair protein complementing XP-C cells OS=Homo sapiens OX=9606 GN=XPC PE=1 SV=4,0.012,3.684,1,1,2,1,940,105.9,8.9,919,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;membrane;mitochondrion;nucleus,DNA binding;protein binding,"Pf03835, Pf10403, Pf10404, Pf10405",7508,ENSG00000154767.14,XPC,3,Nucleotide excision repair,,Formation of Incision Complex in GG-NER; SUMOylation of DNA damage response and repair proteins; DNA Damage Recognition in GG-NER,11,High,1
Q5T8P6,RNA-binding protein 26 OS=Homo sapiens OX=9606 GN=RBM26 PE=1 SV=3,0.012,3.682,1,1,2,1,1007,113.5,9.16,902,,1,,metabolic process;regulation of biological process,,metal ion binding;protein binding;RNA binding,"Pf00076, Pf00642, Pf01480, Pf13893, Pf14259",64062,ENSG00000139746.15,RBM26,13,,,,0,High,1
Q9NNX6,CD209 antigen OS=Homo sapiens OX=9606 GN=CD209 PE=1 SV=1,0.012,3.678,13,1,2,1,404,45.7,5.47,706,,1,,defense response;regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;extracellular;membrane,metal ion binding;protein binding;receptor activity,"Pf00059, Pf13514",30835,ENSG00000090659.17,CD209,19,Phagosome; Measles; Tuberculosis,,Butyrophilin (BTN) family interactions; CD209 (DC-SIGN) signaling,9,High,1
Q9HCJ0,Trinucleotide repeat-containing gene 6C protein OS=Homo sapiens OX=9606 GN=TNRC6C PE=1 SV=3,0.011,3.668,1,1,1,1,1690,175.9,6.96,316,,1,,regulation of biological process;response to stimulus,cytosol,protein binding;RNA binding,"Pf00076, Pf00627, Pf10427, Pf12938, Pf13893, Pf14259",57690,ENSG00000078687.17,TNRC6C,17,,Endoderm Differentiation,Post-transcriptional silencing by small RNAs; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Ca2+ pathway; Competing endogenous RNAs (ceRNAs) regulate PTEN translation; Regulation of RUNX1 Expression and Activity; MAPK6/MAPK4 signaling; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Pre-NOTCH Transcription and Translation; Oxidative Stress Induced Senescence,30,High,1
Q719H9,BTB/POZ domain-containing protein KCTD1 OS=Homo sapiens OX=9606 GN=KCTD1 PE=1 SV=1,0.012,3.666,3,1,9,1,257,29.4,7.08,4122,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,nucleus,protein binding;transporter activity,Pf02214,284252,ENSG00000134504.12,KCTD1,18,,,Negative regulation of activity of TFAP2 (AP-2) family transcription factors,5,High,1
P62699,Protein yippee-like 5 OS=Homo sapiens OX=9606 GN=YPEL5 PE=1 SV=1,0.012,3.662,8,1,1,1,121,13.8,7.31,377,,1,,transport,extracellular,metal ion binding,Pf03226,51646,ENSG00000119801.12,YPEL5,2,,,Neutrophil degranulation,3,High,1
P08034,Gap junction beta-1 protein OS=Homo sapiens OX=9606 GN=GJB1 PE=1 SV=1,0.012,3.656,4,1,6,1,283,32,8.94,2276,,1,,cell communication;cell organization and biogenesis;transport,cytoplasm;endoplasmic reticulum;membrane,protein binding;transporter activity,"Pf00029, Pf10582",2705,ENSG00000169562.9,GJB1,X,,Neural Crest Differentiation; Common Pathways Underlying Drug Addiction; Calcium Regulation in the Cardiac Cell,Transport of connexins along the secretory pathway; Oligomerization of connexins into connexons,10,High,1
P26992,Ciliary neurotrophic factor receptor subunit alpha OS=Homo sapiens OX=9606 GN=CNTFR PE=1 SV=2,0.012,3.651,3,1,2,1,372,40.6,6.76,857,,1,,regulation of biological process;response to stimulus,membrane,protein binding;receptor activity;signal transducer activity,"Pf00041, Pf00047",1271,ENSG00000122756.14,CNTFR,9,Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction,Adipogenesis,IL-6-type cytokine receptor ligand interactions,8,High,1
Q2M2W7,UPF0450 protein C17orf58 OS=Homo sapiens OX=9606 GN=C17orf58 PE=3 SV=2,0.012,3.649,11,1,3,1,97,11.2,10.68,1019,,1,,,,,,284018,ENSG00000186665.9,C17orf58,17,,,,0,High,1
Q15831,Serine/threonine-protein kinase STK11 OS=Homo sapiens OX=9606 GN=STK11 PE=1 SV=1,0.012,3.649,3,1,1,1,433,48.6,7.43,355,,1,,cell death;cell differentiation;cell growth;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;mitochondrion;nucleus,catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding;RNA binding,"Pf00069, Pf07714, Pf14531",6794,ENSG00000118046.14,STK11,19,Adipocytokine signaling pathway; FoxO signaling pathway; PI3K-Akt signaling pathway; mTOR signaling pathway; Longevity regulating pathway; AMPK signaling pathway,AMP-activated Protein Kinase (AMPK) Signaling; Integrated Breast Cancer Pathway; mir-124 predicted interactions with cell cycle and differentiation; ATM Signaling Network in Development and Disease; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,Energy dependent regulation of mTOR by LKB1-AMPK; Regulation of TP53 Activity through Phosphorylation; AMPK inhibits chREBP transcriptional activation activity,23,High,1
Q68DK2,Zinc finger FYVE domain-containing protein 26 OS=Homo sapiens OX=9606 GN=ZFYVE26 PE=1 SV=3,0.012,3.647,0,1,5,1,2539,284.4,6.39,2347,,1,,cell division;metabolic process;response to stimulus,cytoplasm;cytoskeleton;membrane,metal ion binding;protein binding,Pf01363,23503,,ZFYVE26,14,,,,0,High,1
Q99590,Protein SCAF11 OS=Homo sapiens OX=9606 GN=SCAF11 PE=1 SV=2,0.012,3.646,1,1,4,1,1463,164.6,8.41,1881,,1,,cell organization and biogenesis;metabolic process,nucleus,catalytic activity;metal ion binding;protein binding;RNA binding,"Pf00097, Pf09531, Pf12678, Pf12861, Pf13639, Pf13923, Pf14634, Pf15227, Pf15402",9169,ENSG00000139218.17,SCAF11,12,,Apoptosis,,1,High,1
O60266,Adenylate cyclase type 3 OS=Homo sapiens OX=9606 GN=ADCY3 PE=1 SV=3,0.012,3.644,1,1,33,1,1144,128.9,6.58,16828,,1,,cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;Golgi;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding,Pf00211,109,ENSG00000138031.14,ADCY3,2,Purine metabolism; Retrograde endocannabinoid signaling; Longevity regulating pathway; Dilated cardiomyopathy; Thyroid hormone synthesis; Estrogen signaling pathway; Pathways in cancer; Vibrio cholerae infection; Oxytocin signaling pathway; Gastric acid secretion; Phospholipase D signaling pathway; Melanogenesis; Cholinergic synapse; Glutamatergic synapse; Adrenergic signaling in cardiomyocytes; Chemokine signaling pathway; Circadian entrainment; Salivary secretion; Rap1 signaling pathway; Oocyte meiosis; Platelet activation; Longevity regulating pathway - multiple species; Insulin secretion; Endocrine resistance; cGMP-PKG signaling pathway; Aldosterone synthesis and secretion; Calcium signaling pathway; Morphine addiction; Inflammatory mediator regulation of TRP channels; Bile secretion; Pancreatic secretion; Regulation of lipolysis in adipocytes; Olfactory transduction; GABAergic synapse; Ovarian steroidogenesis; HTLV-I infection; cAMP signaling pathway; Progesterone-mediated oocyte maturation; Vasopressin-regulated water reabsorption; Vascular smooth muscle contraction; Gap junction; GnRH signaling pathway,Human Thyroid Stimulating Hormone (TSH) signaling pathway; Myometrial Relaxation and Contraction Pathways; G Protein Signaling Pathways; Chemokine signaling pathway; Calcium Regulation in the Cardiac Cell,Adenylate cyclase activating pathway; G alpha (z) signalling events; G alpha (s) signalling events; Hedgehog 'off' state; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation in glucagon signalling; PKA activation; Adenylate cyclase inhibitory pathway; CREB phosphorylation through the activation of Adenylate Cyclase,84,High,1
P54132,Bloom syndrome protein OS=Homo sapiens OX=9606 GN=BLM PE=1 SV=1,0.012,3.638,1,1,1,1,1417,158.9,7.49,425,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;cytosol;nucleus,catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding,"Pf00270, Pf00271, Pf00570, Pf08072, Pf09382",641,ENSG00000197299.10,BLM,15,Fanconi anemia pathway; Homologous recombination,,G2/M DNA damage checkpoint; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Meiotic recombination; Processing of DNA double-strand break ends; HDR through Single Strand Annealing (SSA); Regulation of TP53 Activity through Phosphorylation; SUMOylation of DNA damage response and repair proteins; Resolution of D-loop Structures through Holliday Junction Intermediates,32,High,1
P53803,"DNA-directed RNA polymerases I, II, and III subunit RPABC4 OS=Homo sapiens OX=9606 GN=POLR2K PE=1 SV=1",0.012,3.637,12,1,4,1,58,7,9.06,1667,,1,,metabolic process;regulation of biological process;response to stimulus,cytosol;nucleus,catalytic activity;DNA binding;metal ion binding,Pf03604,5440,ENSG00000147669.10,POLR2K,8,Cytosolic DNA-sensing pathway; Epstein-Barr virus infection; Metabolic pathways; Purine metabolism; RNA polymerase; Huntington's disease; Pyrimidine metabolism,Eukaryotic Transcription Initiation,Signaling by FGFR2 IIIa TM; RNA polymerase II transcribes snRNA genes; Abortive elongation of HIV-1 transcript in the absence of Tat; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Tat-mediated HIV elongation arrest and recovery; NoRC negatively regulates rRNA expression; Formation of HIV-1 elongation complex containing HIV-1 Tat; MicroRNA (miRNA) biogenesis; RNA Polymerase III Transcription Termination; Formation of the HIV-1 Early Elongation Complex; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; TP53 Regulates Transcription of DNA Repair Genes; Transcriptional regulation by small RNAs; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; RNA Polymerase II HIV Promoter Escape; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase III Chain Elongation; Transcriptional regulation of pluripotent stem cells; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase I Chain Elongation; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; Formation of TC-NER Pre-Incision Complex; Pausing and recovery of HIV elongation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase I Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase III Abortive And Retractive Initiation; HIV elongation arrest and recovery; RNA Pol II CTD phosphorylation and interaction with CE; Viral Messenger RNA Synthesis; RNA Polymerase I Transcription Termination; RNA Polymerase II Transcription Initiation; mRNA Capping; Dual incision in TC-NER; PIWI-interacting RNA (piRNA) biogenesis; RNA Polymerase III Transcription Initiation From Type 1 Promoter; B-WICH complex positively regulates rRNA expression; Cytosolic sensors of pathogen-associated DNA ; Pausing and recovery of Tat-mediated HIV elongation; RNA Polymerase I Transcription Initiation; Formation of the Early Elongation Complex; RNA Polymerase III Transcription Initiation From Type 2 Promoter,98,High,1
Q8TDY4,"Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ASAP3 PE=1 SV=1",0.012,3.637,1,1,4,1,903,99.1,6.4,184,0,1,1,cell death;cell differentiation;cell division;cell organization and biogenesis;cellular component movement;regulation of biological process;transport,cytoplasm;cytosol;endosome;Golgi;membrane,catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding,"Pf00023, Pf00169, Pf01412, Pf09325, Pf12796, Pf13606, Pf13637, Pf13857",55616,ENSG00000282854.1; ENSG00000088280.18,ASAP3,1; CHR_HSCHR1_4_CTG3,Endocytosis; Fc gamma R-mediated phagocytosis,,,2,High,1
Q13042,Cell division cycle protein 16 homolog OS=Homo sapiens OX=9606 GN=CDC16 PE=1 SV=2,0.012,3.635,1,1,2,1,620,71.6,5.85,424,,1,,cell division;cell proliferation;metabolic process;regulation of biological process,cytoplasm;cytoskeleton;cytosol;nucleus,protein binding,"Pf00515, Pf07719, Pf12895, Pf13374, Pf13414, Pf13424",8881,ENSG00000130177.14,CDC16,13,HTLV-I infection; Oocyte meiosis; Ubiquitin mediated proteolysis; Cell cycle; Progesterone-mediated oocyte maturation,,APC/C:Cdc20 mediated degradation of Cyclin B; Inactivation of APC/C via direct inhibition of the APC/C complex; Autodegradation of Cdh1 by Cdh1:APC/C; APC-Cdc20 mediated degradation of Nek2A; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Antigen processing: Ubiquitination & Proteasome degradation; Phosphorylation of the APC/C; APC/C:Cdc20 mediated degradation of Securin; Separation of Sister Chromatids; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Senescence-Associated Secretory Phenotype (SASP),37,High,1
A6NKL6,Transmembrane protein 200C OS=Homo sapiens OX=9606 GN=TMEM200C PE=2 SV=2,0.012,3.628,2,1,17,1,621,63.9,10.08,6295,,1,,,membrane,,Pf10177,645369,ENSG00000206432.4,TMEM200C,18,,,,0,High,1
Q96CD2,Phosphopantothenoylcysteine decarboxylase OS=Homo sapiens OX=9606 GN=PPCDC PE=1 SV=2,0.012,3.626,8,1,1,1,204,22.4,6.1,457,,1,,metabolic process,cytosol,catalytic activity;protein binding,Pf02441,60490,ENSG00000138621.11,PPCDC,15,Pantothenate and CoA biosynthesis; Metabolic pathways,,Coenzyme A biosynthesis,7,High,1
O14594,Neurocan core protein OS=Homo sapiens OX=9606 GN=NCAN PE=1 SV=3,0.012,3.624,2,1,2,1,1321,143,5.38,156,,1,,cell organization and biogenesis;metabolic process,extracellular;organelle lumen,metal ion binding;protein binding;structural molecule activity,"Pf00008, Pf00059, Pf00084, Pf00193, Pf05109",1463,ENSG00000130287.13,NCAN,19,,Spinal Cord Injury,"ECM proteoglycans; A tetrasaccharide linker sequence is required for GAG synthesis; L1CAM interactions; Dermatan sulfate biosynthesis; Defective CHSY1 causes TPBS; Defective B4GALT7 causes EDS, progeroid type; Defective B3GALT6 causes EDSP2 and SEMDJL1; CS/DS degradation; Defective CHST14 causes EDS, musculocontractural type; Defective CHST3 causes SEDCJD; NCAM1 interactions; Chondroitin sulfate biosynthesis; Defective B3GAT3 causes JDSSDHD",26,High,1
Q96M42,Putative uncharacterized protein encoded by LINC00479 OS=Homo sapiens OX=9606 GN=LINC00479 PE=5 SV=2,0.012,3.623,5,1,204,1,142,15.2,8,96703,,1,,,,,,150135,,LINC00479,21,,,,0,High,1
Q9Y3C1,Nucleolar protein 16 OS=Homo sapiens OX=9606 GN=NOP16 PE=1 SV=2,0.012,3.621,4,1,3,1,178,21.2,9.94,1650,,1,,,nucleus,RNA binding,Pf09420,51491,ENSG00000048162.20,NOP16,5,,,,0,High,1
P01210,Proenkephalin-A OS=Homo sapiens OX=9606 GN=PENK PE=1 SV=1,0.012,3.621,3,1,2,1,267,30.8,5.53,789,,1,,cell communication;cell differentiation;cell proliferation;defense response;metabolic process;regulation of biological process;response to stimulus,extracellular;membrane;organelle lumen,protein binding,Pf01160,5179,ENSG00000181195.10,PENK,8,,,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Peptide ligand-binding receptors; G alpha (i) signalling events,11,High,1
Q9UKZ1,CCR4-NOT transcription complex subunit 11 OS=Homo sapiens OX=9606 GN=CNOT11 PE=1 SV=1,0.012,3.619,2,1,1,1,510,55.2,6.4,369,,1,,cell proliferation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,protein binding,Pf10155,55571,ENSG00000158435.7,C2orf29; CNOT11,2,,,TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Deadenylation of mRNA,9,High,1
Q6P2H3,Centrosomal protein of 85 kDa OS=Homo sapiens OX=9606 GN=CEP85 PE=1 SV=1,0.012,3.602,2,1,2,1,762,85.6,6,674,,1,,cell organization and biogenesis;cellular component movement;regulation of biological process,cytoplasm;cytoskeleton;cytosol;Golgi;nucleus,catalytic activity;motor activity;protein binding;structural molecule activity,"Pf00901, Pf01576, Pf02463, Pf03938, Pf03962, Pf04156, Pf05557, Pf05667, Pf05701, Pf06160, Pf07888, Pf09726, Pf10186, Pf10205, Pf10473, Pf11559, Pf12128, Pf13476, Pf13514, Pf13654, Pf13851, Pf13868, Pf15358, Pf15619",64793,ENSG00000130695.14,CEP85,1,,,,0,High,1
O75167,Phosphatase and actin regulator 2 OS=Homo sapiens OX=9606 GN=PHACTR2 PE=1 SV=2,0.012,3.601,2,1,3,1,634,69.7,8.16,1407,,1,,regulation of biological process;transport,membrane,enzyme regulator activity;protein binding,Pf02755,9749,ENSG00000112419.14,PHACTR2,6,,,Platelet degranulation,4,High,1
P78563,Double-stranded RNA-specific editase 1 OS=Homo sapiens OX=9606 GN=ADARB1 PE=1 SV=1,0.012,3.598,2,1,1,1,741,80.7,9.01,313,,1,,cell communication;cell death;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,cytosol;nucleus,catalytic activity;metal ion binding;protein binding;RNA binding,"Pf00035, Pf02137, Pf13900",104,ENSG00000197381.15,ADARB1,21,,,C6 deamination of adenosine; Formation of editosomes by ADAR proteins,5,High,1
Q06265,Exosome complex component RRP45 OS=Homo sapiens OX=9606 GN=EXOSC9 PE=1 SV=3,0.012,3.593,3,1,2,1,439,48.9,5.29,530,,1,,metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;cytosol;nucleus,catalytic activity;protein binding;RNA binding,"Pf01138, Pf03725",5393,ENSG00000123737.12,EXOSC9,4,RNA degradation,,"Major pathway of rRNA processing in the nucleolus and cytosol; mRNA decay by 3' to 5' exoribonuclease; ATF4 activates genes; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; KSRP (KHSRP) binds and destabilizes mRNA",15,High,1
P12821,Angiotensin-converting enzyme OS=Homo sapiens OX=9606 GN=ACE PE=1 SV=1,0.013,3.583,1,1,1,1,1306,149.6,6.39,510,,1,,cell differentiation;cell proliferation;metabolic process;regulation of biological process;transport,cytoplasm;endosome;extracellular;membrane;vacuole,catalytic activity;metal ion binding;protein binding,Pf01401,1636,ENSG00000159640.15,ACE,17,Hypertrophic cardiomyopathy (HCM); Renin secretion; Renin-angiotensin system; Chagas disease (American trypanosomiasis),ACE Inhibitor Pathway,Metabolism of Angiotensinogen to Angiotensins,8,High,1
Q9HCI7,E3 ubiquitin-protein ligase MSL2 OS=Homo sapiens OX=9606 GN=MSL2 PE=1 SV=2,0.013,3.583,2,1,2,1,577,62.5,7.8,1286,,1,,cell organization and biogenesis;metabolic process,,catalytic activity;metal ion binding,,55167,ENSG00000174579.3,MSL2,3,,,HATs acetylate histones,3,High,1
P51511,Matrix metalloproteinase-15 OS=Homo sapiens OX=9606 GN=MMP15 PE=1 SV=1,0.013,3.573,3,1,3,1,669,75.8,7.46,980,,1,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,membrane,catalytic activity;enzyme regulator activity;metal ion binding;protein binding,"Pf00045, Pf00413, Pf01471, Pf07998, Pf11857",4324,ENSG00000102996.4,MMP15,16,,Matrix Metalloproteinases,Collagen degradation; Activation of Matrix Metalloproteinases,5,High,1
Q96KR7,Phosphatase and actin regulator 3 OS=Homo sapiens OX=9606 GN=PHACTR3 PE=1 SV=1,0.013,3.572,3,1,1,1,559,62.5,9.23,828,,1,,regulation of biological process,nucleus,enzyme regulator activity;protein binding,Pf02755,116154,ENSG00000087495.16,PHACTR3,20,,,,0,High,1
P20292,Arachidonate 5-lipoxygenase-activating protein OS=Homo sapiens OX=9606 GN=ALOX5AP PE=1 SV=2,0.013,3.571,5,1,8,1,161,18.1,8.44,2746,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;membrane;nucleus,antioxidant activity;catalytic activity;enzyme regulator activity;protein binding,Pf01124,241,ENSG00000132965.9,ALOX5AP,13,Fc epsilon RI signaling pathway,Selenium Micronutrient Network; Eicosanoid Synthesis,Synthesis of Leukotrienes (LT) and Eoxins (EX); Synthesis of Lipoxins (LX); Synthesis of 5-eicosatetraenoic acids,10,High,1
Q4AE62,Glycosyltransferase-like domain-containing protein 1 OS=Homo sapiens OX=9606 GN=GTDC1 PE=2 SV=1,0.013,3.571,5,1,1,1,458,52.6,7.25,378,,1,,,,catalytic activity,"Pf00534, Pf12038, Pf13692",79712,ENSG00000121964.14,GTDC1,2,,,,0,High,1
P00451,Coagulation factor VIII OS=Homo sapiens OX=9606 GN=F8 PE=1 SV=1,0.013,3.561,1,1,2,1,2351,266.8,7.36,576,,1,,cell organization and biogenesis;coagulation;defense response;metabolic process;response to stimulus;transport,extracellular;membrane;organelle lumen,catalytic activity;metal ion binding;protein binding,"Pf00394, Pf00754, Pf07731, Pf07732",2157,ENSG00000185010.13,F8,X,Complement and coagulation cascades,Blood Clotting Cascade; Complement and Coagulation Cascades,Platelet degranulation ; Common Pathway of Fibrin Clot Formation; Cargo concentration in the ER; COPII (Coat Protein 2) Mediated Vesicle Transport; Intrinsic Pathway of Fibrin Clot Formation,19,High,1
P82094,TATA element modulatory factor OS=Homo sapiens OX=9606 GN=TMF1 PE=1 SV=2,0.013,3.56,1,1,16,1,1093,122.8,4.92,5925,,1,,cell differentiation;cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endoplasmic reticulum;Golgi;membrane;nucleus,DNA binding;protein binding,"Pf12325, Pf12329",7110,ENSG00000144747.15,TMF1,3,,,Retrograde transport at the Trans-Golgi-Network,4,High,1
Q9P1Y5,Calmodulin-regulated spectrin-associated protein 3 OS=Homo sapiens OX=9606 GN=CAMSAP3 PE=1 SV=2,0.013,3.559,1,1,2,1,1249,134.7,8.35,709,,1,,cell differentiation;cell organization and biogenesis;regulation of biological process,cytoplasm;cytoskeleton,protein binding,"Pf00307, Pf08683, Pf11971",57662,ENSG00000076826.9,CAMSAP3,19,,,,0,High,1
Q9HCH0,Nck-associated protein 5-like OS=Homo sapiens OX=9606 GN=NCKAP5L PE=1 SV=2,0.013,3.558,1,1,3,1,1330,138.9,8.13,993,,1,,cell organization and biogenesis,cytoplasm;cytoskeleton,protein binding,Pf15246,57701,,NCKAP5L,12,,,,0,High,1
Q9NV31,U3 small nucleolar ribonucleoprotein protein IMP3 OS=Homo sapiens OX=9606 GN=IMP3 PE=1 SV=1,0.013,3.548,10,1,2,1,184,21.8,9.5,375,,1,,metabolic process;regulation of biological process,nucleus,protein binding;RNA binding;structural molecule activity,Pf01479,55272,ENSG00000177971.8,IMP3,15,Ribosome biogenesis in eukaryotes,,Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol,6,High,1
O60831,PRA1 family protein 2 OS=Homo sapiens OX=9606 GN=PRAF2 PE=1 SV=1,0.013,3.548,6,1,1,1,178,19.2,9.19,531,,1,,transport,endosome;membrane,,Pf03208,11230,ENSG00000243279.3,PRAF2,X,,,,0,High,1
P51800,Chloride channel protein ClC-Ka OS=Homo sapiens OX=9606 GN=CLCNKA PE=1 SV=1,0.013,3.546,3,1,61,1,687,75.2,7.71,24874,,1,,regulation of biological process;transport,membrane,metal ion binding;protein binding;transporter activity,"Pf00571, Pf00654",1187,ENSG00000186510.11,CLCNKA,1,,,Stimuli-sensing channels,3,High,1
Q53HV7,Single-strand selective monofunctional uracil DNA glycosylase OS=Homo sapiens OX=9606 GN=SMUG1 PE=1 SV=2,0.012,3.53,4,1,3,1,270,29.8,6.62,1455,,1,,metabolic process;response to stimulus,nucleus,catalytic activity;DNA binding;protein binding,Pf03167,23583,ENSG00000123415.15,SMUG1,12,Base excision repair,Fluoropyrimidine Activity,Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Displacement of DNA glycosylase by APEX1,10,High,1
Q9Y2Z2,"Protein MTO1 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=MTO1 PE=1 SV=2",0.012,3.524,2,1,3,1,717,79.9,8.31,1375,,1,,cell organization and biogenesis;metabolic process,mitochondrion,catalytic activity;nucleotide binding;RNA binding,"Pf01134, Pf13932",25821,ENSG00000135297.15,MTO1,6,,,tRNA modification in the mitochondrion,3,High,1
O60318,Germinal-center associated nuclear protein OS=Homo sapiens OX=9606 GN=MCM3AP PE=1 SV=2,0.012,3.524,0,1,1,1,1980,218.3,6.39,458,,1,,transport,cytoplasm;cytosol;membrane;nucleus,catalytic activity;DNA binding,"Pf03399, Pf10075",8888,ENSG00000160294.10,MCM3AP,21,,,,0,High,1
Q9H0F7,ADP-ribosylation factor-like protein 6 OS=Homo sapiens OX=9606 GN=ARL6 PE=1 SV=1,0.012,3.523,5,1,2,1,186,21.1,8.54,581,,1,,cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,"Pf00025, Pf00071, Pf00503, Pf01926, Pf04670, Pf08477, Pf09439",84100,ENSG00000113966.9,ARL6,3,,,BBSome-mediated cargo-targeting to cilium,4,High,1
Q6AWC2,Protein WWC2 OS=Homo sapiens OX=9606 GN=WWC2 PE=1 SV=2,0.012,3.523,1,1,3,1,1192,133.8,5.53,1066,,1,,regulation of biological process,cytosol,protein binding;structural molecule activity,Pf00397,80014,ENSG00000151718.15,WWC2,4,,,,0,High,1
Q6UWH4,Golgi-associated kinase 1B OS=Homo sapiens OX=9606 GN=GASK1B PE=2 SV=1,0.012,3.521,2,1,5,1,519,57.5,9.7,1289,,1,,,Golgi;membrane,,Pf15051,51313,ENSG00000164125.15,FAM198B,4,,,,0,High,1
Q8N9F7,Lysophospholipase D GDPD1 OS=Homo sapiens OX=9606 GN=GDPD1 PE=1 SV=2,0.012,3.519,4,1,2,1,314,36.1,8.47,735,,1,,metabolic process,cytoplasm;membrane,catalytic activity;metal ion binding,"Pf03009, Pf13653",284161,ENSG00000153982.10,GDPD1,17,,,Glycerophospholipid catabolism,5,High,1
Q8TF42,Ubiquitin-associated and SH3 domain-containing protein B OS=Homo sapiens OX=9606 GN=UBASH3B PE=1 SV=2,0.012,3.512,1,1,2,1,649,72.6,6.93,833,,1,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,catalytic activity;protein binding,"Pf00018, Pf00300, Pf00627, Pf13563, Pf14604",84959,ENSG00000154127.9,UBASH3B,11,,,,0,High,1
Q86WG5,Myotubularin-related protein 13 OS=Homo sapiens OX=9606 GN=SBF2 PE=1 SV=1,0.013,3.507,1,1,3,1,1849,208.3,7.06,804,,1,,cell organization and biogenesis;regulation of biological process,cytoplasm;cytosol;membrane,enzyme regulator activity;protein binding,"Pf00169, Pf02141, Pf03455, Pf03456, Pf06602, Pf12335, Pf14593, Pf15413",81846,ENSG00000133812.15,SBF2,11,,,Synthesis of PIPs at the plasma membrane; RAB GEFs exchange GTP for GDP on RABs,9,High,1
O75900,Matrix metalloproteinase-23 OS=Homo sapiens OX=9606 GN=MMP23B PE=1 SV=2,0.013,3.5,2,1,9,1,390,43.9,9.89,3717,,1,,metabolic process;reproduction,endoplasmic reticulum;membrane,catalytic activity;metal ion binding;protein binding,"Pf00413, Pf01549, Pf13582, Pf13688, Pf13895",8510,ENSG00000189409.13,MMP23B,1,,Matrix Metalloproteinases,,1,High,1
Q6NW34,Nucleolus and neural progenitor protein OS=Homo sapiens OX=9606 GN=NEPRO PE=1 SV=3,0.013,3.499,2,1,8,1,567,64.5,9.74,1690,,1,,development;regulation of biological process,nucleus,,Pf14780,25871,ENSG00000163608.14,C3orf17; NEPRO,3,,,,0,High,1
Q96JX3,Protein SERAC1 OS=Homo sapiens OX=9606 GN=SERAC1 PE=1 SV=1,0.013,3.499,2,1,3,1,654,74.1,7.68,1116,,1,,cell organization and biogenesis;metabolic process,endoplasmic reticulum;membrane;mitochondrion,catalytic activity,Pf07819,84947,ENSG00000122335.13,SERAC1,6,,,,0,High,1
Q9UF83,Uncharacterized protein DKFZp434B061 OS=Homo sapiens OX=9606 PE=2 SV=2,0.013,3.497,2,1,1,1,564,59.4,13.07,462,,1,,,,,,,,LOC100271840; LOC101060157,,,,,0,High,1
Q9BVK8,Transmembrane protein 147 OS=Homo sapiens OX=9606 GN=TMEM147 PE=1 SV=1,0.013,3.497,3,1,1,1,224,25.2,7.71,570,,1,,regulation of biological process,endoplasmic reticulum;membrane,protein binding,Pf09767,10430,ENSG00000105677.11,TMEM147,19,,,,0,High,1
Q16769,Glutaminyl-peptide cyclotransferase OS=Homo sapiens OX=9606 GN=QPCT PE=1 SV=1,0.013,3.496,4,1,2,1,361,40.9,6.61,718,,1,,metabolic process;transport,extracellular;organelle lumen,catalytic activity;metal ion binding,Pf04389,25797,ENSG00000115828.15,QPCT,2,,,Neutrophil degranulation,3,High,1
Q9P2K2,Thioredoxin domain-containing protein 16 OS=Homo sapiens OX=9606 GN=TXNDC16 PE=1 SV=4,0.013,3.494,1,1,5,1,825,93.5,5.21,2601,,1,,cellular homeostasis;regulation of biological process,endoplasmic reticulum;extracellular;organelle lumen,protein binding,"Pf00085, Pf13848",57544,ENSG00000087301.8,TXNDC16,14,,,,0,High,1
Q13671,Ras and Rab interactor 1 OS=Homo sapiens OX=9606 GN=RIN1 PE=1 SV=4,0.013,3.49,1,1,4,1,783,84,8.02,2105,,1,,regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane,enzyme regulator activity;protein binding,"Pf00788, Pf02204, Pf04632",9610,ENSG00000174791.10,RIN1,11,Ras signaling pathway,EGF/EGFR Signaling Pathway,RAB GEFs exchange GTP for GDP on RABs,6,High,1
Q92733,Proline-rich protein PRCC OS=Homo sapiens OX=9606 GN=PRCC PE=1 SV=1,0.013,3.485,2,1,1,1,491,52.4,5.1,381,,1,,metabolic process;regulation of biological process,nucleus,protein binding,Pf10253,5546,ENSG00000143294.14,PRCC,1,Transcriptional misregulation in cancer,,mRNA Splicing - Major Pathway,5,High,1
Q8N5D0,WD and tetratricopeptide repeats protein 1 OS=Homo sapiens OX=9606 GN=WDTC1 PE=1 SV=2,0.013,3.484,2,1,1,1,677,75.9,7.27,433,,1,,cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cytosol;nucleus,enzyme regulator activity;protein binding,"Pf00400, Pf00515, Pf12895, Pf13414, Pf13424, Pf13432, Pf14559",23038,ENSG00000142784.15,WDTC1,1,,,Neddylation,3,High,1
Q8N9I9,Probable E3 ubiquitin-protein ligase DTX3 OS=Homo sapiens OX=9606 GN=DTX3 PE=1 SV=2,0.013,3.479,4,1,5,1,347,38,8.73,1765,,1,,metabolic process;regulation of biological process;response to stimulus,cytoplasm,catalytic activity;metal ion binding;protein binding,"Pf00097, Pf12678, Pf13639, Pf13920, Pf13923, Pf14634, Pf15227",196403,ENSG00000178498.15,DTX3,12,Notch signaling pathway,Notch Signaling Pathway,,2,High,1
Q99732,Lipopolysaccharide-induced tumor necrosis factor-alpha factor OS=Homo sapiens OX=9606 GN=LITAF PE=1 SV=2,0.013,3.478,4,1,10,1,161,17.1,6.44,3786,,1,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endosome;Golgi;membrane;nucleus;vacuole,DNA binding;metal ion binding;protein binding;signal transducer activity,Pf10601,9516,ENSG00000189067.12,LITAF,16,Lysosome,,,1,High,1
Q8NDT2,Putative RNA-binding protein 15B OS=Homo sapiens OX=9606 GN=RBM15B PE=1 SV=3,0.013,3.476,1,1,1,1,890,97.1,9.85,471,,1,,metabolic process;regulation of biological process;transport,nucleus,protein binding;RNA binding,"Pf00076, Pf07744, Pf08777, Pf13893, Pf14259",29890,ENSG00000259956.1,RBM15B,3,,,,0,High,1
Q5JWR5,Protein dopey-1 OS=Homo sapiens OX=9606 GN=DOP1A PE=2 SV=1,0.013,3.475,1,1,2,1,2465,277.2,6.29,818,,1,,transport,cytosol;endosome,,Pf04118,23033,ENSG00000083097.14,DOPEY1,6,,,,0,High,1
Q8NAV1,Pre-mRNA-splicing factor 38A OS=Homo sapiens OX=9606 GN=PRPF38A PE=1 SV=1,0.013,3.474,4,1,2,1,312,37.5,9.96,734,,1,,cell organization and biogenesis;metabolic process,membrane;nucleus;spliceosomal complex,protein binding;RNA binding,Pf03371,84950,ENSG00000134748.12,PRPF38A,1,Spliceosome,Mecp2 and Associated Rett Syndrome,mRNA Splicing - Major Pathway,6,High,1
Q8WUR7,UPF0235 protein C15orf40 OS=Homo sapiens OX=9606 GN=C15orf40 PE=1 SV=2,0.013,3.471,8,1,1,1,153,16.3,9.83,428,,1,,,,,Pf02594,123207,ENSG00000169609.13,C15orf40,15,,,,0,High,1
O00628,Peroxisomal targeting signal 2 receptor OS=Homo sapiens OX=9606 GN=PEX7 PE=1 SV=1,0.013,3.47,4,1,1,1,323,35.9,5.73,249,,1,,cell organization and biogenesis;cellular component movement;metabolic process;transport,cytoplasm;cytosol;organelle lumen,protein binding,Pf00400,5191,ENSG00000112357.12,PEX7,6,Peroxisome,,,1,High,1
Q01974,Tyrosine-protein kinase transmembrane receptor ROR2 OS=Homo sapiens OX=9606 GN=ROR2 PE=1 SV=2,0.013,3.468,1,1,3,1,943,104.7,6.55,1031,,1,,cell differentiation;development;metabolic process;regulation of biological process;response to stimulus,cell surface;cytoplasm;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding;receptor activity;signal transducer activity,"Pf00047, Pf00051, Pf00069, Pf01392, Pf07679, Pf07686, Pf07714, Pf13895, Pf13927",4920,ENSG00000169071.14,ROR2,9,,Cardiac Progenitor Differentiation; Ectoderm Differentiation; Wnt Signaling Pathway Netpath; Wnt Signaling Pathway,"WNT5A-dependent internalization of FZD2, FZD5 and ROR2",9,High,1
Q4LDE5,"Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SVEP1 PE=1 SV=3",0.013,3.466,0,1,3,1,3571,389.9,5.5,846,,1,,,cell surface;cytoplasm;extracellular;membrane,metal ion binding;protein binding,"Pf00008, Pf00084, Pf00092, Pf00354, Pf02210, Pf02494, Pf06247, Pf07645, Pf07699, Pf12947, Pf13385, Pf13519",79987,ENSG00000165124.17,SVEP1,9,,,,0,High,1
Q5VV17,OTU domain-containing protein 1 OS=Homo sapiens OX=9606 GN=OTUD1 PE=1 SV=1,0.013,3.465,4,1,1,1,481,51,6.05,351,,1,,metabolic process,,catalytic activity,Pf02338,220213,ENSG00000165312.6,OTUD1,10,,,,0,High,1
Q9H1C4,Protein unc-93 homolog B1 OS=Homo sapiens OX=9606 GN=UNC93B1 PE=1 SV=2,0.013,3.46,2,1,1,1,597,66.6,6.96,330,,1,,defense response;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;endosome;membrane;vacuole,protein binding,Pf05978,81622,ENSG00000110057.7,UNC93B1,11,,,Trafficking and processing of endosomal TLR; UNC93B1 deficiency - HSE,8,High,1
Q96MG7,Non-structural maintenance of chromosomes element 3 homolog OS=Homo sapiens OX=9606 GN=NSMCE3 PE=1 SV=1,0.013,3.459,3,1,2,1,304,34.3,9.28,1061,,1,,metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;nucleus,protein binding,Pf01454,56160,ENSG00000185115.5; ENSG00000282130.1,NDNL2; NSMCE3,15; CHR_HSCHR15_4_CTG8,,,SUMOylation of DNA damage response and repair proteins,5,High,1
P07359,Platelet glycoprotein Ib alpha chain OS=Homo sapiens OX=9606 GN=GP1BA PE=1 SV=2,0.014,3.448,2,1,3,1,652,71.5,6.29,1121,,1,,cell organization and biogenesis;coagulation;metabolic process;regulation of biological process;response to stimulus,cell surface;cytoplasm;membrane,enzyme regulator activity;protein binding;receptor activity;signal transducer activity,"Pf01462, Pf12799, Pf13855",2811,ENSG00000185245.7,GP1BA,17,ECM-receptor interaction; Platelet activation; Hematopoietic cell lineage,,Platelet Aggregation (Plug Formation); Intrinsic Pathway of Fibrin Clot Formation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling,15,High,1
Q96H79,Zinc finger CCCH-type antiviral protein 1-like OS=Homo sapiens OX=9606 GN=ZC3HAV1L PE=1 SV=2,0.014,3.447,8,1,1,1,300,32.9,8.13,365,,1,,,cytosol,metal ion binding,,92092,ENSG00000146858.7,ZC3HAV1L,7,,,,0,High,1
Q96EV2,RNA-binding protein 33 OS=Homo sapiens OX=9606 GN=RBM33 PE=1 SV=3,0.014,3.446,1,1,7,1,1170,129.9,6.93,1978,,1,,,,RNA binding,Pf14259,155435,ENSG00000184863.10,RBM33,7,,,,0,High,1
Q8NFZ0,F-box DNA helicase 1 OS=Homo sapiens OX=9606 GN=FBH1 PE=1 SV=2,0.014,3.431,1,1,2,1,1043,117.6,8.25,628,,1,,cell death;metabolic process;regulation of biological process;response to stimulus,chromosome;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding,"Pf00580, Pf00646, Pf12937, Pf13086, Pf13245, Pf13361, Pf13538",84893,ENSG00000134452.19,FBXO18,10,,,,0,High,1
Q96MC5,bMERB domain-containing protein 1 OS=Homo sapiens OX=9606 GN=BMERB1 PE=1 SV=1,0.014,3.431,5,1,4,1,204,23.7,6.16,2237,,1,,regulation of biological process,cytoskeleton,protein binding,Pf12130,89927,ENSG00000166780.10; ENSG00000278823.4,C16orf45,16; CHR_HSCHR16_1_CTG1,,,,0,High,1
Q9Y6V0,Protein piccolo OS=Homo sapiens OX=9606 GN=PCLO PE=1 SV=5,0.014,3.429,0,1,32,1,5142,560.4,6.47,13076,,1,,,,,,,,,,,,,0,High,1
P43694,Transcription factor GATA-4 OS=Homo sapiens OX=9606 GN=GATA4 PE=1 SV=2,0.014,3.421,5,1,2,1,442,44.5,9.26,446,,1,,cell communication;cell differentiation;cell growth;cellular homeostasis;coagulation;metabolic process;regulation of biological process;response to stimulus,nucleus,DNA binding;metal ion binding;protein binding,"Pf00320, Pf05349",2626,ENSG00000136574.17,GATA4,8,Thyroid hormone signaling pathway; cGMP-PKG signaling pathway,Physiological and Pathological Hypertrophy  of the Heart; MicroRNAs in cardiomyocyte hypertrophy; Heart Development; Adipogenesis; Cardiac Progenitor Differentiation; Endoderm Differentiation; Serotonin Receptor 2 and ELK-SRF/GATA4 signaling,"Physiological factors; Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP); YAP1- and WWTR1 (TAZ)-stimulated gene expression; Factors involved in megakaryocyte development and platelet production",22,High,1
P31513,Dimethylaniline monooxygenase [N-oxide-forming] 3 OS=Homo sapiens OX=9606 GN=FMO3 PE=1 SV=5,0.014,3.418,2,1,5,1,532,60,7.78,1610,,1,,metabolic process,endoplasmic reticulum;membrane,catalytic activity;nucleotide binding;protein binding,"Pf00743, Pf13434, Pf13450, Pf13738",2328,ENSG00000007933.12,FMO3,1,Drug metabolism - cytochrome P450,Nicotine Metabolism; Catalytic cycle of mammalian Flavin-containing MonoOxygenases (FMOs); Tamoxifen metabolism; Metapathway biotransformation; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,Defective FMO3 causes Trimethylaminuria (TMAU); FMO oxidises nucleophiles,14,High,1
P58511,Small integral membrane protein 11A OS=Homo sapiens OX=9606 GN=SMIM11A PE=2 SV=1,0.014,3.409,26,1,1,1,58,6.9,9.86,216,,1,,,membrane,,Pf14981,54065; 102723553,ENSG00000205670.10; ENSG00000273590.4,FAM165B; SMIM11; SMIM11A; LOC102723553; SMIM11B,21,,,,0,High,1
Q9Y6Q9,Nuclear receptor coactivator 3 OS=Homo sapiens OX=9606 GN=NCOA3 PE=1 SV=1,0.014,3.402,1,1,2,1,1424,155.2,7.47,640,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,"Pf00989, Pf07469, Pf08815, Pf08832, Pf13426, Pf14598",8202,ENSG00000124151.18,NCOA3,20,Breast cancer; Thyroid hormone signaling pathway; Endocrine resistance,Androgen receptor signaling pathway; Integrated Breast Cancer Pathway; EGF/EGFR Signaling Pathway,MAPK6/MAPK4 signaling; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression,17,High,1
Q14527,Helicase-like transcription factor OS=Homo sapiens OX=9606 GN=HLTF PE=1 SV=2,0.014,3.397,1,1,1,1,1009,113.9,8.6,547,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;membrane;nucleus,catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding,"Pf00097, Pf00176, Pf00271, Pf08797, Pf12678, Pf12861, Pf13445, Pf13639, Pf13920, Pf13923, Pf14634, Pf15227",6596,ENSG00000071794.15,HLTF,3,,Retinoblastoma (RB) in Cancer,E3 ubiquitin ligases ubiquitinate target proteins,5,High,1
Q49AH0,Cerebral dopamine neurotrophic factor OS=Homo sapiens OX=9606 GN=CDNF PE=1 SV=2,0.014,3.394,7,1,2,1,187,21,7.55,546,,1,,cell differentiation;cell organization and biogenesis;regulation of biological process,endoplasmic reticulum;extracellular,protein binding,Pf10208,441549,ENSG00000185267.9,CDNF,10,,,,0,High,1
O00268,Transcription initiation factor TFIID subunit 4 OS=Homo sapiens OX=9606 GN=TAF4 PE=1 SV=2,0.014,3.393,4,1,3,1,1085,110,9.94,198,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,cytosol;nucleus,DNA binding;protein binding,"Pf05236, Pf07531, Pf13868",6874,ENSG00000130699.18,TAF4,20,Huntington's disease; Herpes simplex infection; Basal transcription factors,,RNA Polymerase II Transcription Initiation; HIV Transcription Initiation; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; RNA Polymerase II Promoter Escape,22,High,1
O75689,Arf-GAP with dual PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ADAP1 PE=1 SV=2,0.014,3.391,3,1,3,1,374,43.4,8.97,897,,1,,regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,enzyme regulator activity;metal ion binding;protein binding,"Pf00169, Pf01412, Pf15413",11033,ENSG00000105963.13,ADAP1,7,,,,0,High,1
A6NGB9,WAS/WASL-interacting protein family member 3 OS=Homo sapiens OX=9606 GN=WIPF3 PE=1 SV=4,0.014,3.382,5,1,2,1,483,49.4,10.15,524,,1,,cell differentiation;development;regulation of biological process;response to stimulus,cytoplasm;cytosol,protein binding,Pf02205,644150,ENSG00000122574.10,WIPF3,7,Endocytosis,,Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs,9,High,1
Q15032,R3H domain-containing protein 1 OS=Homo sapiens OX=9606 GN=R3HDM1 PE=1 SV=3,0.014,3.377,1,1,3,1,1099,120.6,8.75,1288,,1,,,,RNA binding,"Pf01424, Pf09770",23518,ENSG00000048991.16,R3HDM1,2,,,,0,High,1
Q9UKZ9,Procollagen C-endopeptidase enhancer 2 OS=Homo sapiens OX=9606 GN=PCOLCE2 PE=1 SV=1,0.014,3.377,2,1,13,1,415,45.7,8.47,4751,,1,,regulation of biological process,extracellular,enzyme regulator activity;protein binding,"Pf00431, Pf01759",26577,ENSG00000163710.7,PCOLCE2,3,,,Collagen biosynthesis and modifying enzymes,3,High,1
Q13480,GRB2-associated-binding protein 1 OS=Homo sapiens OX=9606 GN=GAB1 PE=1 SV=2,0.014,3.376,2,1,1,1,694,76.6,5.96,214,,1,,cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytosol,catalytic activity;protein binding,"Pf00169, Pf14593, Pf15409, Pf15413",2549,ENSG00000109458.8,GAB1,4,ErbB signaling pathway; Proteoglycans in cancer; Phospholipase D signaling pathway; Ras signaling pathway; Renal cell carcinoma; Neurotrophin signaling pathway; Bacterial invasion of epithelial cells; EGFR tyrosine kinase inhibitor resistance,Signaling Pathways in Glioblastoma; B Cell Receptor Signaling Pathway; Alpha 6 Beta 4 signaling pathway; Signaling of Hepatocyte Growth Factor Receptor; IL-6 signaling pathway; BDNF-TrkB Signaling; VEGFA-VEGFR2 Signaling Pathway; ESC Pluripotency Pathways; EGF/EGFR Signaling Pathway; Insulin Signaling; ErbB Signaling Pathway,"PI3K Cascade; Signaling by FGFR4 in disease; PI-3K cascade:FGFR3; Signaling by FGFR2 in disease; Signaling by FGFR3 fusions in cancer; MET activates RAP1 and RAC1; Signaling by FGFR3 point mutants in cancer; Signaling by FGFR1 in disease; MET activates PTPN11; PI-3K cascade:FGFR4; Constitutive Signaling by Aberrant PI3K in Cancer; MET activates PI3K/AKT signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Constitutive Signaling by EGFRvIII; MET receptor recycling; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; PI-3K cascade:FGFR2; RET signaling; GAB1 signalosome; PI3K events in ERBB2 signaling; PI-3K cascade:FGFR1",74,High,1
Q96DB2,Histone deacetylase 11 OS=Homo sapiens OX=9606 GN=HDAC11 PE=1 SV=1,0.014,3.373,4,1,2,1,347,39.2,7.65,370,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,membrane;nucleus,catalytic activity;protein binding,Pf00850,79885,ENSG00000163517.14,HDAC11,3,Viral carcinogenesis; Alcoholism,Neural Crest Differentiation,Constitutive Signaling by NOTCH1 PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants,14,High,1
Q14596,Next to BRCA1 gene 1 protein OS=Homo sapiens OX=9606 GN=NBR1 PE=1 SV=3,0.014,3.37,1,1,2,1,966,107.3,5.12,781,,1,,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;endosome;membrane;mitochondrion;vacuole,metal ion binding;protein binding,"Pf00564, Pf00569",4077,ENSG00000188554.13,NBR1,17,,,,0,High,1
Q99518,Dimethylaniline monooxygenase [N-oxide-forming] 2 OS=Homo sapiens OX=9606 GN=FMO2 PE=1 SV=5,0.014,3.366,2,1,5,1,535,60.9,8.28,1953,,1,,metabolic process,membrane,catalytic activity;nucleotide binding,"Pf00743, Pf07992, Pf13434, Pf13450, Pf13738",2327,ENSG00000094963.13,FMO2,1,Drug metabolism - cytochrome P450,Catalytic cycle of mammalian Flavin-containing MonoOxygenases (FMOs); Metapathway biotransformation,,3,High,1
Q9ULR5,Polyadenylate-binding protein-interacting protein 2B OS=Homo sapiens OX=9606 GN=PAIP2B PE=1 SV=2,0.014,3.364,24,1,1,1,123,14.2,4.17,281,,1,,regulation of biological process,cytoplasm,protein binding;translation regulator activity,Pf07145,400961,ENSG00000124374.8,PAIP2B,2,,,,0,High,1
P55287,Cadherin-11 OS=Homo sapiens OX=9606 GN=CDH11 PE=1 SV=2,0.014,3.357,2,1,1,1,796,87.9,4.91,289,,1,,cell organization and biogenesis,cytoplasm;membrane,metal ion binding,"Pf00028, Pf01049",1009,ENSG00000140937.13,CDH11,16,,,Adherens junctions interactions,4,High,1
Q13421,Mesothelin OS=Homo sapiens OX=9606 GN=MSLN PE=1 SV=2,0.014,3.355,1,1,3,1,630,68.9,6.38,1284,,1,,metabolic process,cell surface;extracellular;Golgi;membrane;organelle lumen,protein binding,Pf06060,10232,ENSG00000102854.15,MSLN,16,,,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational modification: synthesis of GPI-anchored proteins,5,High,1
Q53RE8,Ankyrin repeat domain-containing protein 39 OS=Homo sapiens OX=9606 GN=ANKRD39 PE=1 SV=1,0.014,3.347,5,1,3,1,183,19.6,6.89,1164,,1,,,,protein binding,"Pf00023, Pf12796, Pf13606, Pf13637, Pf13857",51239,ENSG00000213337.8,ANKRD39,2,,,,0,High,1
O77932,Decapping and exoribonuclease protein OS=Homo sapiens OX=9606 GN=DXO PE=2 SV=2,0.014,3.346,5,1,1,1,396,44.9,7.69,362,,1,,metabolic process;regulation of biological process,cytosol;membrane;nucleus,catalytic activity;metal ion binding;nucleotide binding;RNA binding,Pf08652,1797,ENSG00000234798.6; ENSG00000225682.6; ENSG00000224313.6; ENSG00000206346.8; ENSG00000204348.9,DOM3Z; DXO,6; CHR_HSCHR6_MHC_SSTO_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_QBL_CTG1,,,,0,High,1
P15907,"Beta-galactoside alpha-2,6-sialyltransferase 1 OS=Homo sapiens OX=9606 GN=ST6GAL1 PE=1 SV=1",0.014,3.346,2,1,2,1,406,46.6,9.01,820,,1,,metabolic process;response to stimulus,extracellular;Golgi;membrane,catalytic activity;protein binding,Pf00777,6480,ENSG00000073849.14,ST6GAL1,3,N-Glycan biosynthesis; Other types of O-glycan biosynthesis; Metabolic pathways,Globo Sphingolipid Metabolism,N-Glycan antennae elongation; Termination of O-glycan biosynthesis; Sialic acid metabolism,16,High,1
Q9BWN1,Proline-rich protein 14 OS=Homo sapiens OX=9606 GN=PRR14 PE=1 SV=1,0.014,3.342,2,1,2,1,585,64.3,10.35,799,,1,,,chromosome;nucleus,protein binding,Pf15386,78994,ENSG00000156858.11,PRR14,16,,,,0,High,1
Q6UW56,All-trans retinoic acid-induced differentiation factor OS=Homo sapiens OX=9606 GN=ATRAID PE=1 SV=2,0.014,3.341,3,1,1,1,229,24.7,7.25,417,,1,,cell differentiation;regulation of biological process,membrane;nucleus,protein binding,,51374,ENSG00000138085.16,ATRAID,2,,,,0,High,1
Q7LGC8,Carbohydrate sulfotransferase 3 OS=Homo sapiens OX=9606 GN=CHST3 PE=1 SV=3,0.014,3.333,2,1,50,1,479,54.7,8.59,17177,,1,,metabolic process,Golgi;membrane,catalytic activity,Pf00685,9469,ENSG00000122863.5,CHST3,10,Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate,Metapathway biotransformation,Defective CHST3 causes SEDCJD; Chondroitin sulfate biosynthesis,11,High,1
Q96II8,DISP complex protein LRCH3 OS=Homo sapiens OX=9606 GN=LRCH3 PE=1 SV=2,0.014,3.333,2,1,2,1,777,86,6.71,807,,1,,regulation of biological process;response to stimulus,cytosol;extracellular;membrane,protein binding,"Pf00307, Pf12799, Pf13855",84859,ENSG00000186001.12,LRCH3,3,,,,0,High,1
P26374,Rab proteins geranylgeranyltransferase component A 2 OS=Homo sapiens OX=9606 GN=CHML PE=1 SV=2,0.014,3.327,1,1,11,1,656,74,4.93,3708,,1,,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol,catalytic activity;enzyme regulator activity;protein binding,"Pf00996, Pf12831, Pf13450",1122,ENSG00000203668.2,CHML,1,,,RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation,7,High,1
P48061,Stromal cell-derived factor 1 OS=Homo sapiens OX=9606 GN=CXCL12 PE=1 SV=1,0.014,3.316,9,1,3,1,93,10.7,9.88,922,,1,,cell organization and biogenesis;cellular component movement;cellular homeostasis;defense response;regulation of biological process;response to stimulus,cytoplasm;extracellular;membrane,protein binding,Pf00048,6387,ENSG00000107562.16,CXCL12,10,Leukocyte transendothelial migration; Intestinal immune network for IgA production; Pathways in cancer; Chemokine signaling pathway; NF-kappa B signaling pathway; Cytokine-cytokine receptor interaction; Rheumatoid arthritis; Axon guidance,Allograft Rejection; EV release from cardiac cells and their functional effects; RIG-I-like Receptor Signaling; Chemokine signaling pathway,Signaling by ROBO receptors; Chemokine receptors bind chemokines; G alpha (i) signalling events; Nuclear signaling by ERBB4,26,High,1
P03897,NADH-ubiquinone oxidoreductase chain 3 OS=Homo sapiens OX=9606 GN=MT-ND3 PE=1 SV=1,0.015,3.309,13,1,2,1,115,13.2,4.44,,3.89,,1,cell organization and biogenesis;metabolic process;response to stimulus;transport,membrane;mitochondrion,catalytic activity;protein binding,Pf00507,4537,ENSG00000198840.2,ND3,MT,Metabolic pathways; Oxidative phosphorylation; Parkinson's disease,Electron Transport Chain; Oxidative phosphorylation,Complex I biogenesis,10,High,1
P42685,Tyrosine-protein kinase FRK OS=Homo sapiens OX=9606 GN=FRK PE=1 SV=1,0.015,3.305,3,1,2,1,505,58.2,6.67,560,,1,,cell differentiation;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;extracellular;membrane;nucleus;organelle lumen,catalytic activity;nucleotide binding;protein binding,"Pf00017, Pf00018, Pf00069, Pf07653, Pf07714, Pf14604",2444,ENSG00000111816.7,FRK,6,,,Regulation of PTEN stability and activity; Neutrophil degranulation,8,High,1
Q8IY45,Protein AMN1 homolog OS=Homo sapiens OX=9606 GN=AMN1 PE=2 SV=4,0.015,3.304,4,1,3,1,258,28.4,7.85,833,,1,,,,protein binding,,196394,ENSG00000151743.10,AMN1,12,,,,0,High,1
Q92828,Coronin-2A OS=Homo sapiens OX=9606 GN=CORO2A PE=1 SV=2,0.015,3.304,2,1,2,1,525,59.7,8.05,1088,,1,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoskeleton,protein binding,"Pf00400, Pf08953, Pf08954",7464,ENSG00000106789.12,CORO2A,9,,,,0,High,1
E7ETH6,Zinc finger protein 587B OS=Homo sapiens OX=9606 GN=ZNF587B PE=1 SV=1,0.015,3.303,2,1,12,1,402,45.5,8.38,4694,,1,,regulation of biological process,nucleus,metal ion binding,"Pf00096, Pf01352, Pf13465",100293516,ENSG00000269343.6,ZNF587B,19,,,,0,High,1
Q9NRX1,RNA-binding protein PNO1 OS=Homo sapiens OX=9606 GN=PNO1 PE=1 SV=1,0.015,3.298,6,1,2,1,252,27.9,9.73,543,,1,,metabolic process,cytosol;nucleus,RNA binding,Pf00013,56902,ENSG00000115946.7,PNO1,2,,,Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol,5,High,1
Q8TCT8,Signal peptide peptidase-like 2A OS=Homo sapiens OX=9606 GN=SPPL2A PE=1 SV=2,0.015,3.295,2,1,1,1,520,58.1,8.32,411,,1,,metabolic process;regulation of biological process,endosome;membrane;vacuole,catalytic activity;protein binding,"Pf02225, Pf04258",84888,ENSG00000138600.9,SPPL2A,15,,,Regulation of TNFR1 signaling,4,High,1
P20908,Collagen alpha-1(V) chain OS=Homo sapiens OX=9606 GN=COL5A1 PE=1 SV=3,0.015,3.279,1,1,2,1,1838,183.4,5.06,597,,1,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process,extracellular;organelle lumen,metal ion binding;protein binding;structural molecule activity,"Pf01391, Pf01410, Pf02210, Pf13385",1289,ENSG00000130635.15,COL5A1,9,Protein digestion and absorption,Allograft Rejection; miRNA targets in ECM and membrane receptors; Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; miR-509-3p alteration of YAP1/ECM axis,ECM proteoglycans; Collagen degradation; Integrin cell surface interactions; Assembly of collagen fibrils and other multimeric structures; MET activates PTK2 signaling; Collagen chain trimerization; NCAM1 interactions; Signaling by PDGF; Syndecan interactions,27,High,1
Q15542,Transcription initiation factor TFIID subunit 5 OS=Homo sapiens OX=9606 GN=TAF5 PE=1 SV=3,0.015,3.27,4,1,2,1,800,86.8,5.64,245,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoskeleton;nucleus,catalytic activity;DNA binding;protein binding,"Pf00400, Pf04494, Pf08662",6877,ENSG00000148835.10,TAF5,10,Basal transcription factors; Herpes simplex infection,Eukaryotic Transcription Initiation,RNA polymerase II transcribes snRNA genes; RNA Polymerase II Transcription Initiation; HIV Transcription Initiation; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; RNA Polymerase II Promoter Escape,23,High,1
Q86YS7,C2 domain-containing protein 5 OS=Homo sapiens OX=9606 GN=C2CD5 PE=1 SV=1,0.015,3.268,1,1,1,1,1000,110.4,5.69,415,,1,,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane,metal ion binding;protein binding,"Pf00168, Pf01906",9847,ENSG00000111731.12,C2CD5; KIAA0528,12,,,Translocation of GLUT4 to the plasma membrane,3,High,1
Q92817,Envoplakin OS=Homo sapiens OX=9606 GN=EVPL PE=1 SV=3,0.015,3.265,0,1,7,1,2033,231.5,6.96,2695,,1,,cell death;cell differentiation;metabolic process,cytoplasm;cytoskeleton;cytosol,protein binding;structural molecule activity,"Pf00681, Pf05667",2125,ENSG00000167880.7,EVPL,17,,,Formation of the cornified envelope,3,High,1
Q96CG8,Collagen triple helix repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=CTHRC1 PE=1 SV=1,0.015,3.258,3,1,1,1,243,26.2,7.99,329,,1,,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cytoplasm;extracellular,protein binding,Pf01391,115908,ENSG00000164932.12,CTHRC1,8,,,,0,High,1
Q01543,Friend leukemia integration 1 transcription factor OS=Homo sapiens OX=9606 GN=FLI1 PE=1 SV=1,0.015,3.255,4,1,3,1,452,51,7.06,911,,1,,cell differentiation;metabolic process;regulation of biological process,cytosol;nucleus,DNA binding;protein binding,"Pf00178, Pf02198",2313,ENSG00000151702.16,FLI1,11,Transcriptional misregulation in cancer,,,1,High,1
Q12860,Contactin-1 OS=Homo sapiens OX=9606 GN=CNTN1 PE=1 SV=1,0.015,3.255,1,1,3,1,1018,113.2,5.9,1144,,1,,cell organization and biogenesis;regulation of biological process;response to stimulus,membrane,protein binding,"Pf00041, Pf00047, Pf07679, Pf07686, Pf13895, Pf13927",1272,ENSG00000018236.14,CNTN1,12,Cell adhesion molecules (CAMs),,Activated NOTCH1 Transmits Signal to the Nucleus; NOTCH2 Activation and Transmission of Signal to the Nucleus; Neurofascin interactions,11,High,1
Q9UFF9,CCR4-NOT transcription complex subunit 8 OS=Homo sapiens OX=9606 GN=CNOT8 PE=1 SV=1,0.015,3.251,6,1,2,1,292,33.5,4.81,696,,1,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;protein binding;RNA binding,Pf04857,9337,ENSG00000155508.13,CNOT8,5,RNA degradation,,TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Deadenylation of mRNA,10,High,1
Q6ZWL3,Cytochrome P450 4V2 OS=Homo sapiens OX=9606 GN=CYP4V2 PE=1 SV=2,0.015,3.25,2,1,3,1,525,60.7,7.5,1124,,1,,metabolic process;response to stimulus,endoplasmic reticulum;membrane,catalytic activity;metal ion binding,Pf00067,285440,ENSG00000145476.15,CYP4V2,4,,Oxidation by Cytochrome P450; Metapathway biotransformation,Signaling by GPCR; The canonical retinoid cycle in rods (twilight vision); Endogenous sterols,11,High,1
Q9H668,CST complex subunit STN1 OS=Homo sapiens OX=9606 GN=STN1 PE=1 SV=2,0.015,3.245,2,1,3,1,368,42.1,6.07,1099,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,chromosome;cytoskeleton;nucleus,DNA binding;protein binding,"Pf09170, Pf10451",79991,ENSG00000107960.10,OBFC1; STN1,10,,Lung fibrosis,,1,High,1
Q9GZU1,Mucolipin-1 OS=Homo sapiens OX=9606 GN=MCOLN1 PE=1 SV=1,0.015,3.244,5,1,1,1,580,65,7.24,290,,1,,cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport,cytosol;endosome;membrane;vacuole,protein binding;transporter activity,"Pf00520, Pf08016",57192,ENSG00000090674.15,MCOLN1,19,Lysosome,Iron metabolism in placenta,TRP channels; Transferrin endocytosis and recycling,8,High,1
P20827,Ephrin-A1 OS=Homo sapiens OX=9606 GN=EFNA1 PE=1 SV=2,0.015,3.244,4,1,4,1,205,23.8,6.83,1286,,1,,cell communication;cell differentiation;cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,extracellular;membrane,protein binding,Pf00812,1942,ENSG00000169242.11,EFNA1,1,Rap1 signaling pathway; Axon guidance; PI3K-Akt signaling pathway; Ras signaling pathway,Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,EPH-ephrin mediated repulsion of cells; EPHA-mediated growth cone collapse,10,High,1
Q8WYP3,Ras and Rab interactor 2 OS=Homo sapiens OX=9606 GN=RIN2 PE=1 SV=1,0.015,3.242,1,1,1,1,895,100.1,6.58,307,,1,,regulation of biological process;response to stimulus;transport,cytoplasm;cytosol,enzyme regulator activity,"Pf00788, Pf02204",54453,,RIN2,20,,,RAB GEFs exchange GTP for GDP on RABs,4,High,1
O95926,Pre-mRNA-splicing factor SYF2 OS=Homo sapiens OX=9606 GN=SYF2 PE=1 SV=1,0.015,3.241,5,1,1,1,243,28.7,8.4,429,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,nucleus;spliceosomal complex,protein binding;RNA binding,Pf08231,25949,ENSG00000117614.9,SYF2,1,Spliceosome,,mRNA Splicing - Major Pathway,5,High,1
Q16322,Potassium voltage-gated channel subfamily A member 10 OS=Homo sapiens OX=9606 GN=KCNA10 PE=1 SV=2,0.015,3.236,6,1,1,1,511,57.7,4.93,669,,1,,cell organization and biogenesis;regulation of biological process;transport,membrane,protein binding;transporter activity,"Pf00520, Pf02214, Pf07885",3744,ENSG00000143105.7,KCNA10,1,,,Voltage gated Potassium channels,3,High,1
Q9H4B6,Protein salvador homolog 1 OS=Homo sapiens OX=9606 GN=SAV1 PE=1 SV=2,0.015,3.234,2,1,16,1,383,44.6,9.09,7023,,1,,cell death;cell differentiation;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,protein binding;structural molecule activity,Pf00397,60485,ENSG00000151748.14,SAV1,14,Hippo signaling pathway; Hippo signaling pathway -multiple species,,Signaling by Hippo,4,High,1
Q5JS37,NHL repeat-containing protein 3 OS=Homo sapiens OX=9606 GN=NHLRC3 PE=2 SV=1,0.015,3.229,5,1,1,1,347,38.3,6.43,215,,1,,transport,extracellular;organelle lumen,protein binding,Pf01436,387921,ENSG00000188811.13,NHLRC3,13,,,Neutrophil degranulation,3,High,1
Q9UKY4,Protein O-mannosyl-transferase 2 OS=Homo sapiens OX=9606 GN=POMT2 PE=1 SV=2,0.015,3.227,1,1,2,1,750,84.2,9.16,610,,1,,metabolic process;response to stimulus,endoplasmic reticulum;membrane,catalytic activity;metal ion binding,"Pf02366, Pf02815",29954,ENSG00000009830.11,POMT2,14,Other types of O-glycan biosynthesis,,"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2; O-linked glycosylation",8,High,1
P52701,DNA mismatch repair protein Msh6 OS=Homo sapiens OX=9606 GN=MSH6 PE=1 SV=2,0.015,3.226,1,1,3,1,1360,152.7,6.9,1010,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;cytosol;Golgi;nucleus,catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding,"Pf00488, Pf00855, Pf01624, Pf05188, Pf05190, Pf05192",2956,ENSG00000116062.14,MSH6,2,Mismatch repair; Colorectal cancer; Platinum drug resistance; Pathways in cancer,Signaling Pathways in Glioblastoma; Retinoblastoma (RB) in Cancer; Mismatch repair,Defective Mismatch Repair Associated With MSH2; Defective Mismatch Repair Associated With MSH6; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha),14,High,1
Q9Y657,Spindlin-1 OS=Homo sapiens OX=9606 GN=SPIN1 PE=1 SV=3,0.015,3.223,4,1,1,1,262,29.6,6.96,395,,1,,cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus,cytosol;membrane;nucleus,protein binding,Pf02513,10927,ENSG00000106723.16,SPIN1,9,,,,0,High,1
P28329,Choline O-acetyltransferase OS=Homo sapiens OX=9606 GN=CHAT PE=1 SV=4,0.015,3.222,2,1,8,1,748,82.5,8.59,4543,,1,,metabolic process;transport,cytoplasm;cytosol;nucleus,catalytic activity,Pf00755,1103,ENSG00000070748.18,CHAT,10,Glycerophospholipid metabolism; Cholinergic synapse,Acetylcholine Synthesis; Biogenic Amine Synthesis; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,Synthesis of PC; Acetylcholine Neurotransmitter Release Cycle,14,High,1
O75818,Ribonuclease P protein subunit p40 OS=Homo sapiens OX=9606 GN=RPP40 PE=1 SV=3,0.016,3.215,2,1,2,1,363,41.8,6.67,876,,1,,metabolic process,nucleus,catalytic activity,Pf08584,10799,ENSG00000124787.13,RPP40,6,Ribosome biogenesis in eukaryotes; RNA transport,,Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus,8,High,1
Q9UBY5,Lysophosphatidic acid receptor 3 OS=Homo sapiens OX=9606 GN=LPAR3 PE=2 SV=1,0.016,3.214,2,1,6,1,353,40.1,9.42,2821,,1,,cell communication;cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus,membrane,protein binding;receptor activity;signal transducer activity,Pf00001,23566,ENSG00000171517.5,LPAR3,1,PI3K-Akt signaling pathway; Neuroactive ligand-receptor interaction; Phospholipase D signaling pathway; Pathways in cancer; Rap1 signaling pathway,Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,Lysosphingolipid and LPA receptors; Gastrin-CREB signalling pathway via PKC and MAPK; G alpha (i) signalling events,15,High,1
Q96K37,Solute carrier family 35 member E1 OS=Homo sapiens OX=9606 GN=SLC35E1 PE=1 SV=2,0.016,3.212,3,1,2,1,410,44.7,9.79,880,,1,,transport,Golgi;membrane,,"Pf03151, Pf08449",79939,ENSG00000127526.14,SLC35E1,19,,,,0,High,1
Q9NQW1,Protein transport protein Sec31B OS=Homo sapiens OX=9606 GN=SEC31B PE=1 SV=1,0.016,3.208,1,1,10,1,1179,128.6,8.29,4852,,1,,transport,cytoplasm;endoplasmic reticulum;membrane,protein binding,"Pf00400, Pf03154, Pf03276",25956,ENSG00000075826.16,SEC31B,10,Protein processing in endoplasmic reticulum,Sterol Regulatory Element-Binding Proteins (SREBP) signalling,,2,High,1
Q99608,Necdin OS=Homo sapiens OX=9606 GN=NDN PE=1 SV=1,0.016,3.197,2,1,8,1,321,36.1,8.78,2695,,1,,cell growth;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,DNA binding;protein binding,Pf01454,4692,ENSG00000182636.5,NDN,15,,Adipogenesis,Interleukin-4 and 13 signaling,5,High,1
Q8N2W9,E3 SUMO-protein ligase PIAS4 OS=Homo sapiens OX=9606 GN=PIAS4 PE=1 SV=1,0.016,3.195,1,1,74,1,510,56.5,6.14,32016,,1,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,catalytic activity;DNA binding;metal ion binding;protein binding,"Pf02037, Pf02891, Pf11789, Pf14324",51588,ENSG00000105229.6,PIAS4,19,Ubiquitin mediated proteolysis; NF-kappa B signaling pathway; Jak-STAT signaling pathway,Androgen receptor signaling pathway,G2/M DNA damage checkpoint; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of transcription factors; Processing of DNA double-strand break ends; SUMOylation of DNA replication proteins; Nonhomologous End-Joining (NHEJ); SUMOylation of DNA damage response and repair proteins,23,High,1
O75718,Cartilage-associated protein OS=Homo sapiens OX=9606 GN=CRTAP PE=1 SV=1,0.016,3.192,3,1,2,1,401,46.5,5.73,625,,1,,metabolic process;regulation of biological process,endoplasmic reticulum;extracellular;organelle lumen,protein binding,,10491,ENSG00000170275.14,CRTAP,3,,,Collagen biosynthesis and modifying enzymes,3,High,1
Q8N6Y2,Leucine-rich repeat-containing protein 17 OS=Homo sapiens OX=9606 GN=LRRC17 PE=2 SV=1,0.016,3.192,3,1,4,1,441,51.8,8.24,863,,1,,cell differentiation;cell proliferation;regulation of biological process,extracellular,protein binding,"Pf12799, Pf13855",10234,ENSG00000128606.12,LRRC17,7,,,,0,High,1
Q5HYW2,NHS-like protein 2 OS=Homo sapiens OX=9606 GN=NHSL2 PE=1 SV=2,0.016,3.191,1,1,4,1,1225,133.2,7.77,,3.71,,1,,,,,,,,,,,,0,High,1
Q8IU60,m7GpppN-mRNA hydrolase OS=Homo sapiens OX=9606 GN=DCP2 PE=1 SV=3,0.016,3.189,2,1,1,1,420,48.4,8,406,,1,,metabolic process;regulation of biological process,cytosol,catalytic activity;metal ion binding;protein binding;RNA binding,"Pf00293, Pf05026",167227,ENSG00000172795.15,DCP2,5,RNA degradation,,,1,High,1
Q3B726,DNA-directed RNA polymerase I subunit RPA43 OS=Homo sapiens OX=9606 GN=TWISTNB PE=1 SV=1,0.016,3.189,2,1,15,1,338,37.4,6.98,5562,,1,,metabolic process;regulation of biological process,nucleus,catalytic activity,Pf03876,221830,ENSG00000105849.5,TWISTNB,7,Purine metabolism; Pyrimidine metabolism; RNA polymerase; Metabolic pathways,,RNA Polymerase I Chain Elongation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Termination; RNA Polymerase I Promoter Escape; B-WICH complex positively regulates rRNA expression; RNA Polymerase I Transcription Initiation,16,High,1
Q86SJ6,Desmoglein-4 OS=Homo sapiens OX=9606 GN=DSG4 PE=1 SV=1,0.016,3.169,1,1,6,1,1040,113.8,4.56,2543,,1,,cell death;cell differentiation;regulation of biological process;response to stimulus,cytoskeleton;membrane,metal ion binding,"Pf00028, Pf01049",147409,ENSG00000175065.11,DSG4,18,,,Formation of the cornified envelope,3,High,1
Q9BRP4,Proteasomal ATPase-associated factor 1 OS=Homo sapiens OX=9606 GN=PAAF1 PE=1 SV=2,0.016,3.165,3,1,2,1,392,42.2,6.32,729,,1,,,proteasome,protein binding,Pf00400,80227,ENSG00000175575.12,PAAF1,11,,,,0,High,1
Q9Y3A4,Ribosomal RNA-processing protein 7 homolog A OS=Homo sapiens OX=9606 GN=RRP7A PE=1 SV=2,0.016,3.161,4,1,1,1,280,32.3,9.58,287,,1,,cell organization and biogenesis;metabolic process,cytoplasm,protein binding;RNA binding,"Pf00076, Pf12923",27341,ENSG00000189306.10,RRP7A,22,Ribosome biogenesis in eukaryotes,,Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol,6,High,1
Q96PU4,E3 ubiquitin-protein ligase UHRF2 OS=Homo sapiens OX=9606 GN=UHRF2 PE=1 SV=1,0.016,3.16,2,1,1,1,802,89.9,8.21,368,,1,,cell differentiation;cell proliferation;metabolic process;regulation of biological process,nucleus,catalytic activity;DNA binding;metal ion binding;protein binding,"Pf00097, Pf00240, Pf00628, Pf02182, Pf12148, Pf13639, Pf13923, Pf14634",115426,ENSG00000147854.16,UHRF2,9,,,,0,High,1
Q9UHK6,Alpha-methylacyl-CoA racemase OS=Homo sapiens OX=9606 GN=AMACR PE=1 SV=2,0.016,3.159,4,1,4,1,382,42.4,6.44,1009,,1,,metabolic process,cytoplasm;membrane;mitochondrion;organelle lumen,catalytic activity;protein binding,Pf02515,23600,ENSG00000242110.7,AMACR,5,Metabolic pathways; Primary bile acid biosynthesis; Peroxisome,,Beta-oxidation of pristanoyl-CoA; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Synthesis of bile acids and bile salts via 24-hydroxycholesterol,13,High,1
Q8WUX2,Glutathione-specific gamma-glutamylcyclotransferase 2 OS=Homo sapiens OX=9606 GN=CHAC2 PE=1 SV=1,0.016,3.159,9,1,2,1,184,20.9,5.43,747,,1,,metabolic process,cytoplasm;cytosol,catalytic activity,Pf04752,494143,ENSG00000143942.4,CHAC2,2,,,Glutathione synthesis and recycling,5,High,1
Q9BRN9,TM2 domain-containing protein 3 OS=Homo sapiens OX=9606 GN=TM2D3 PE=2 SV=2,0.016,3.156,3,1,3,1,247,27.1,8.03,1125,,1,,,membrane,,Pf05154,80213,ENSG00000184277.12,TM2D3,15,,,,0,High,1
P58215,Lysyl oxidase homolog 3 OS=Homo sapiens OX=9606 GN=LOXL3 PE=1 SV=1,0.016,3.154,1,1,1,1,753,83.1,6.86,341,,1,,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;extracellular;membrane;nucleus,catalytic activity;metal ion binding;protein binding;receptor activity,"Pf00530, Pf01186",84695,ENSG00000115318.11,LOXL3,2,,TYROBP Causal Network,Elastic fibre formation; Crosslinking of collagen fibrils,6,High,1
Q96B54,Zinc finger protein 428 OS=Homo sapiens OX=9606 GN=ZNF428 PE=1 SV=2,0.016,3.149,6,1,3,1,188,20.5,4.17,937,,1,,,,metal ion binding,,126299,ENSG00000131116.11,ZNF428,19,,,,0,High,1
Q8N137,Centrobin OS=Homo sapiens OX=9606 GN=CNTROB PE=1 SV=1,0.016,3.146,1,1,5,1,903,101.2,5.54,1988,,1,,cell division;cell organization and biogenesis,cytoplasm;cytoskeleton;cytosol,protein binding,,116840,ENSG00000170037.13,CNTROB,17,,,,0,High,1
P05412,Transcription factor AP-1 OS=Homo sapiens OX=9606 GN=JUN PE=1 SV=2,0.016,3.143,2,1,3,1,331,35.7,8.76,1276,,1,,cell communication;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,chromosome;cytosol;nucleus,DNA binding;enzyme regulator activity;protein binding;RNA binding,"Pf00170, Pf03131, Pf03957, Pf04012, Pf07716",3725,ENSG00000177606.6,JUN,1,NOD-like receptor signaling pathway; Pertussis; Estrogen signaling pathway; Th1 and Th2 cell differentiation; ErbB signaling pathway; GnRH signaling pathway; Leishmaniasis; Non-alcoholic fatty liver disease (NAFLD); Amphetamine addiction; Wnt signaling pathway; T cell receptor signaling pathway; AGE-RAGE signaling pathway in diabetic complications; cAMP signaling pathway; Viral carcinogenesis; Breast cancer; Herpes simplex infection; Neurotrophin signaling pathway; Choline metabolism in cancer; Osteoclast differentiation; HTLV-I infection; Rheumatoid arthritis; MAPK signaling pathway; Cocaine addiction; TNF signaling pathway; Renal cell carcinoma; Influenza A; B cell receptor signaling pathway; Salmonella infection; Inflammatory bowel disease (IBD); Pathways in cancer; Epithelial cell signaling in Helicobacter pylori infection; Epstein-Barr virus infection; Focal adhesion; Chagas disease (American trypanosomiasis); Colorectal cancer; Endocrine resistance; Hepatitis B; Apoptosis; Oxytocin signaling pathway; Toll-like receptor signaling pathway,IL-5 Signaling Pathway; Androgen receptor signaling pathway; Regulation of toll-like receptor signaling pathway; Physiological and Pathological Hypertrophy  of the Heart; IL-1 signaling pathway; Integrated Breast Cancer Pathway; RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway; Human Thyroid Stimulating Hormone (TSH) signaling pathway; TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway; Prolactin Signaling Pathway; B Cell Receptor Signaling Pathway; TNF alpha Signaling Pathway; AGE/RAGE pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis; ATM Signaling Pathway; Apoptosis; Selenium Metabolism and Selenoproteins; IL-3 Signaling Pathway; Aryl Hydrocarbon Receptor Pathway; Estrogen Receptor Pathway; Myometrial Relaxation and Contraction Pathways; Focal Adhesion; Signaling of Hepatocyte Growth Factor Receptor; Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation; Copper homeostasis; MFAP5-mediated ovarian cancer cell motility and invasiveness; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Hepatitis C and Hepatocellular Carcinoma; TGF-beta Signaling Pathway; Association Between Physico-Chemical Features and Toxicity Associated Pathways; MAPK Signaling Pathway; T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 Signaling Pathway; BMP Signaling Pathway in Eyelid Development; ESC Pluripotency Pathways; Wnt Signaling Pathway and Pluripotency; MAPK Cascade; Wnt Signaling Pathway; EGF/EGFR Signaling Pathway; Insulin Signaling; IL-2 Signaling Pathway; TGF-beta Receptor Signaling; Senescence and Autophagy in Cancer; ErbB Signaling Pathway; T-Cell antigen Receptor (TCR)  Signaling Pathway; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways; DNA Damage Response (only ATM dependent); Estrogen signaling pathway; Toll-like receptor signaling pathway,Activation of anterior HOX genes in hindbrain development during early embryogenesis; FCERI mediated MAPK activation; Activated TLR4 signalling; TP53 Regulates Transcription of DNA Repair Genes; Activation of the AP-1 family of transcription factors; Pre-NOTCH Transcription and Translation; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Regulation of PTEN gene transcription; MAPK6/MAPK4 signaling; Senescence-Associated Secretory Phenotype (SASP); Oxidative Stress Induced Senescence,143,High,1
Q9BQ13,BTB/POZ domain-containing protein KCTD14 OS=Homo sapiens OX=9606 GN=KCTD14 PE=1 SV=2,0.016,3.14,3,1,2,1,255,29.6,8.59,1218,,1,,cell organization and biogenesis,,protein binding,"Pf00651, Pf02214",65987; 100532726,ENSG00000151364.16,KCTD14; NDUFC2-KCTD14,11,,,,0,High,1
P32246,C-C chemokine receptor type 1 OS=Homo sapiens OX=9606 GN=CCR1 PE=1 SV=1,0.016,3.14,3,1,1,1,355,41.1,8.16,478,,1,,cell communication;cellular component movement;cellular homeostasis;defense response;regulation of biological process;response to stimulus;transport,membrane,catalytic activity;protein binding;receptor activity;signal transducer activity,Pf00001,1230,ENSG00000163823.3,CCR1,3,Chemokine signaling pathway; Cytokine-cytokine receptor interaction,"Peptide GPCRs; Chemokine signaling pathway; GPCRs, Class A Rhodopsin-like",Interleukin-10 signaling; Chemokine receptors bind chemokines; G alpha (i) signalling events,17,High,1
Q9H7E2,Tudor domain-containing protein 3 OS=Homo sapiens OX=9606 GN=TDRD3 PE=1 SV=1,0.016,3.139,1,1,12,1,651,73.1,9.23,4333,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;nucleus,protein binding;RNA binding,"Pf00567, Pf00627, Pf06003",81550,ENSG00000083544.13,TDRD3,13,,,,0,High,1
Q9Y3B9,RRP15-like protein OS=Homo sapiens OX=9606 GN=RRP15 PE=1 SV=2,0.016,3.136,4,1,3,1,282,31.5,5.52,1160,,1,,metabolic process,,,Pf07890,51018,ENSG00000067533.5,RRP15,1,,,,0,High,1
Q9Y4E5,E3 SUMO-protein ligase ZNF451 OS=Homo sapiens OX=9606 GN=ZNF451 PE=1 SV=2,0.016,3.135,1,1,1,1,1061,121.4,6.77,338,,1,,metabolic process;regulation of biological process,nucleus,catalytic activity;metal ion binding;protein binding,,26036,ENSG00000112200.16,ZNF451,6,,,,0,High,1
Q9BTA9,WW domain-containing adapter protein with coiled-coil OS=Homo sapiens OX=9606 GN=WAC PE=1 SV=3,0.016,3.127,3,1,1,1,647,70.7,9.45,354,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,nucleus;spliceosomal complex,protein binding,Pf00397,51322,ENSG00000095787.21,WAC,10,,,E3 ubiquitin ligases ubiquitinate target proteins,4,High,1
Q147U7,Single-pass membrane and coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SMCO1 PE=2 SV=2,0.016,3.126,5,1,2,1,214,24.6,9.11,,4.33,,1,,membrane,,Pf15080,255798,ENSG00000214097.4,C3orf43; SMCO1,3,,,,0,High,1
Q8NCJ5,SPRY domain-containing protein 3 OS=Homo sapiens OX=9606 GN=SPRYD3 PE=1 SV=2,0.016,3.125,2,1,3,1,442,49.7,6.16,1075,,1,,,,protein binding,Pf00622,84926,ENSG00000167778.8,SPRYD3,12,,,,0,High,1
P20929,Nebulin OS=Homo sapiens OX=9606 GN=NEB PE=1 SV=5,0.016,3.12,0,1,3,1,6669,772.4,9.07,988,,1,,cell organization and biogenesis;cellular component movement;regulation of biological process,cytoplasm;cytoskeleton;cytosol,protein binding;structural molecule activity,"Pf00018, Pf00880, Pf14604",4703,ENSG00000183091.19,NEB,2,,Striated Muscle Contraction; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling,Striated Muscle Contraction,4,High,1
Q5T7V8,RAB6-interacting golgin OS=Homo sapiens OX=9606 GN=GORAB PE=1 SV=1,0.016,3.117,3,1,4,1,394,45,7.08,1353,,1,,regulation of biological process,cytoplasm;cytosol;Golgi;nucleus,protein binding,Pf04949,92344,ENSG00000120370.12,GORAB,1,p53 signaling pathway,,,1,High,1
Q96HB5,Coiled-coil domain-containing protein 120 OS=Homo sapiens OX=9606 GN=CCDC120 PE=1 SV=1,0.016,3.109,1,1,1,1,630,67.5,9.38,262,,1,,cell organization and biogenesis;development,cytoplasm;endosome,protein binding,Pf11819,90060,ENSG00000147144.12,CCDC120,X,,,,0,High,1
Q68DH5,G-protein coupled receptor-associated protein LMBRD2 OS=Homo sapiens OX=9606 GN=LMBRD2 PE=1 SV=1,0.016,3.107,2,1,5,1,695,81.1,7.5,1785,,1,,,membrane,,Pf04791,92255,ENSG00000164187.6,LMBRD2,5,,,,0,High,1
Q99551,"Transcription termination factor 1, mitochondrial OS=Homo sapiens OX=9606 GN=MTERF1 PE=1 SV=1",0.016,3.107,4,1,1,1,399,45.7,9.42,386,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,cytosol;mitochondrion;organelle lumen,DNA binding;protein binding;RNA binding,Pf02536,7978,ENSG00000127989.13,MTERF; MTERF1,7,,Mitochondrial Gene Expression,Transcriptional activation of mitochondrial biogenesis; Mitochondrial transcription termination,7,High,1
Q96JQ2,Calmin OS=Homo sapiens OX=9606 GN=CLMN PE=1 SV=1,0.016,3.104,1,1,2,1,1002,111.6,4.94,786,,1,,cell organization and biogenesis;regulation of biological process,cytoplasm;membrane,protein binding,Pf00307,79789,ENSG00000165959.11,CLMN,14,,,,0,High,1
Q8N5G2,Macoilin OS=Homo sapiens OX=9606 GN=MACO1 PE=1 SV=1,0.016,3.104,2,1,2,1,664,76.1,9.07,516,,1,,,membrane;nucleus,catalytic activity;motor activity,"Pf01576, Pf05667, Pf08614, Pf09726, Pf12128, Pf13493, Pf14264, Pf15619",55219,ENSG00000204178.9,TMEM57; MACO1,1,,,,0,High,1
O43597,Protein sprouty homolog 2 OS=Homo sapiens OX=9606 GN=SPRY2 PE=1 SV=1,0.016,3.103,5,1,2,1,315,34.7,8.35,339,,1,,cell organization and biogenesis;development;regulation of biological process,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,enzyme regulator activity;protein binding,Pf05210,10253,ENSG00000136158.11,SPRY2,13,MicroRNAs in cancer,Signaling Pathways in Glioblastoma; Ectoderm Differentiation; EGF/EGFR Signaling Pathway,Spry regulation of FGF signaling; EGFR downregulation,18,High,1
Q9UPQ3,"Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=AGAP1 PE=1 SV=4",0.016,3.097,1,1,2,1,857,94.4,7.94,702,,1,,regulation of biological process;response to stimulus;transport,cytoplasm,catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding,"Pf00023, Pf00071, Pf00169, Pf01412, Pf08477, Pf12796, Pf13606, Pf13637, Pf13857",116987,ENSG00000157985.18,AGAP1,2,Endocytosis,,,1,High,1
Q5MY95,Ectonucleoside triphosphate diphosphohydrolase 8 OS=Homo sapiens OX=9606 GN=ENTPD8 PE=1 SV=2,0.016,3.097,2,1,8,1,495,53.9,5.31,3455,,1,,metabolic process,membrane,catalytic activity;metal ion binding;nucleotide binding,Pf01150,377841,ENSG00000188833.9,ENTPD8,9,Purine metabolism; Pyrimidine metabolism; Epstein-Barr virus infection,,Phosphate bond hydrolysis by NTPDase proteins,7,High,1
Q6PJW8,Consortin OS=Homo sapiens OX=9606 GN=CNST PE=1 SV=3,0.016,3.096,2,1,3,1,725,79.5,4.53,748,,1,,regulation of biological process,Golgi;membrane,protein binding,Pf15281,163882,ENSG00000162852.13,CNST,1,,,,0,High,1
Q96DT6,Cysteine protease ATG4C OS=Homo sapiens OX=9606 GN=ATG4C PE=1 SV=1,0.016,3.095,2,1,1,1,458,52.5,5.97,407,,1,,cell organization and biogenesis;metabolic process;transport,cytoplasm;cytosol;extracellular,catalytic activity,Pf03416,84938,ENSG00000125703.14,ATG4C,1,Autophagy,,Macroautophagy,3,High,1
Q9NPJ6,Mediator of RNA polymerase II transcription subunit 4 OS=Homo sapiens OX=9606 GN=MED4 PE=1 SV=1,0.016,3.094,6,1,2,1,270,29.7,5.1,360,,1,,metabolic process;regulation of biological process;response to stimulus,membrane;nucleus,protein binding;receptor activity,Pf10018,29079,ENSG00000136146.14,MED4,13,Thyroid hormone signaling pathway,,Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway,10,High,1
O75478,Transcriptional adapter 2-alpha OS=Homo sapiens OX=9606 GN=TADA2A PE=1 SV=3,0.016,3.091,2,1,7,1,443,51.5,6.89,2734,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,chromosome;nucleus,catalytic activity;DNA binding;protein binding,"Pf00249, Pf04433",6871,ENSG00000277104.4,TADA2A,17; CHR_HSCHR17_7_CTG4,,,HATs acetylate histones,3,High,1
Q6P3R8,Serine/threonine-protein kinase Nek5 OS=Homo sapiens OX=9606 GN=NEK5 PE=2 SV=1,0.016,3.091,2,1,2,1,708,81.4,8.87,734,,1,,metabolic process;regulation of biological process,,catalytic activity;metal ion binding;nucleotide binding,"Pf00069, Pf07714, Pf14531",341676,ENSG00000197168.11,NEK5,13,,,,0,High,1
Q15833,Syntaxin-binding protein 2 OS=Homo sapiens OX=9606 GN=STXBP2 PE=1 SV=2,0.016,3.087,1,1,28,1,593,66.4,6.55,10989,,1,,regulation of biological process;transport,cytosol;extracellular;membrane;vacuole,protein binding,Pf00995,6813,ENSG00000076944.15,STXBP2,19,,Insulin Signaling,Platelet degranulation ; Other interleukin signaling,9,High,1
Q9HBR0,Putative sodium-coupled neutral amino acid transporter 10 OS=Homo sapiens OX=9606 GN=SLC38A10 PE=1 SV=2,0.016,3.084,1,1,2,1,1119,119.7,5.73,728,,1,,transport,Golgi;membrane,transporter activity,"Pf01490, Pf03595",124565,ENSG00000157637.12,SLC38A10,17,,,,0,High,1
Q9H6K5,Proline-rich protein 36 OS=Homo sapiens OX=9606 GN=PRR36 PE=1 SV=2,0.016,3.081,1,1,4,1,1346,132.7,10.48,1669,,1,,,,,Pf15363,80164,ENSG00000183248.11,FLJ22184; PRR36,19,,,,0,High,1
P05107,Integrin beta-2 OS=Homo sapiens OX=9606 GN=ITGB2 PE=1 SV=2,0.017,3.079,2,1,1,1,769,84.7,6.95,370,,1,,cell communication;cell death;cell differentiation;cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;membrane,metal ion binding;protein binding;receptor activity;signal transducer activity,"Pf00362, Pf07965, Pf08725",3689,,ITGB2,21,Regulation of actin cytoskeleton; Rap1 signaling pathway; Rheumatoid arthritis; HTLV-I infection; Leukocyte transendothelial migration; Cell adhesion molecules (CAMs); Phagosome; Amoebiasis; Viral myocarditis; Natural killer cell mediated cytotoxicity; Malaria; Hippo signaling pathway; Staphylococcus aureus infection; Tuberculosis; Complement and coagulation cascades; Leishmaniasis; Legionellosis; Pertussis,Integrin-mediated Cell Adhesion; Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Microglia Pathogen Phagocytosis Pathway; TYROBP Causal Network,Integrin cell surface interactions; Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Toll Like Receptor 4 (TLR4) Cascade; Cell surface interactions at the vascular wall; Interleukin-4 and 13 signaling,37,High,1
O14593,DNA-binding protein RFXANK OS=Homo sapiens OX=9606 GN=RFXANK PE=1 SV=2,0.017,3.075,5,1,1,1,260,28.1,4.55,327,,1,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,DNA binding;protein binding,"Pf00023, Pf12796, Pf13606, Pf13637, Pf13857",8625,ENSG00000064490.13,RFXANK,19,Primary immunodeficiency; Antigen processing and presentation; Tuberculosis,,,3,High,1
Q86UY6,N-alpha-acetyltransferase 40 OS=Homo sapiens OX=9606 GN=NAA40 PE=1 SV=1,0.017,3.073,5,1,2,1,237,27.2,7.39,535,,1,,cell organization and biogenesis;metabolic process,cytoplasm;nucleus,catalytic activity;protein binding,Pf00583,79829,ENSG00000110583.12,NAA40,11,,Metapathway biotransformation,,1,High,1
O14512,Suppressor of cytokine signaling 7 OS=Homo sapiens OX=9606 GN=SOCS7 PE=1 SV=2,0.017,3.071,1,1,5,1,581,62.9,8.06,2412,,1,,cell differentiation;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,enzyme regulator activity;protein binding,"Pf00017, Pf07525",30837,ENSG00000274229.2; ENSG00000274211.4,SOCS7,17; CHR_HSCHR17_7_CTG4,Prolactin signaling pathway; Jak-STAT signaling pathway,Leptin signaling pathway,,3,High,1
O75152,Zinc finger CCCH domain-containing protein 11A OS=Homo sapiens OX=9606 GN=ZC3H11A PE=1 SV=3,0.017,3.069,1,1,2,1,810,89.1,8.37,554,,1,,metabolic process;transport,,metal ion binding;protein binding;RNA binding,,9877,ENSG00000058673.16; ENSG00000257315.2,ZC3H11A,1,,,Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing,9,High,1
Q9GZK3,Olfactory receptor 2B2 OS=Homo sapiens OX=9606 GN=OR2B2 PE=2 SV=1,0.017,3.065,6,1,12,1,357,40.4,8.25,4439,,1,,regulation of biological process;response to stimulus,membrane,receptor activity;signal transducer activity,"Pf00001, Pf13853",81697,ENSG00000168131.4,OR2B2,6,Olfactory transduction,"GPCRs, Class A Rhodopsin-like",Olfactory Signaling Pathway; GPCR downstream signalling,6,High,1
P30414,NK-tumor recognition protein OS=Homo sapiens OX=9606 GN=NKTR PE=1 SV=2,0.017,3.064,1,1,1,1,1462,165.6,9.99,358,,1,,metabolic process,cytosol;membrane;mitochondrion,catalytic activity,"Pf00160, Pf09726",4820,ENSG00000114857.17,NKTR,3,,,,0,High,1
Q9BTV7,CDK5 and ABL1 enzyme substrate 2 OS=Homo sapiens OX=9606 GN=CABLES2 PE=1 SV=3,0.017,3.063,3,1,1,1,478,52.2,9.82,,0,,1,cell division;regulation of biological process,,,Pf00134,81928,ENSG00000149679.11,CABLES2,20,,,Factors involved in megakaryocyte development and platelet production,2,High,1
P10586,Receptor-type tyrosine-protein phosphatase F OS=Homo sapiens OX=9606 GN=PTPRF PE=1 SV=2,0.017,3.063,1,1,1,1,1907,212.7,6.3,330,,1,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,membrane,catalytic activity;protein binding;receptor activity;signal transducer activity,"Pf00041, Pf00047, Pf00102, Pf07679, Pf13895, Pf13927, Pf14566",5792,ENSG00000142949.16,PTPRF,1,Insulin signaling pathway; Insulin resistance; Cell adhesion molecules (CAMs); Adherens junction,Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Insulin Signaling,Receptor-type tyrosine-protein phosphatases; Synaptic adhesion-like molecules,10,High,1
Q96CN9,GRIP and coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=GCC1 PE=1 SV=1,0.017,3.062,1,1,4,1,775,87.8,5.45,2133,,1,,metabolic process;transport,cytoplasm;cytosol;Golgi;membrane,protein binding,"Pf01465, Pf04111, Pf12128",79571,ENSG00000179562.2,GCC1,7,,,Retrograde transport at the Trans-Golgi-Network,4,High,1
Q11206,"CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 OS=Homo sapiens OX=9606 GN=ST3GAL4 PE=2 SV=1",0.017,3.06,3,1,1,1,333,38,9.41,464,,1,,metabolic process,extracellular;Golgi;membrane,catalytic activity,Pf00777,6484,ENSG00000110080.18,ST3GAL4,11,Glycosphingolipid biosynthesis - lacto and neolacto series; Metabolic pathways,,Sialic acid metabolism; Pre-NOTCH Processing in Golgi; Keratan sulfate biosynthesis; N-Glycan antennae elongation; Termination of O-glycan biosynthesis,23,High,1
Q53EQ6,Tigger transposable element-derived protein 5 OS=Homo sapiens OX=9606 GN=TIGD5 PE=1 SV=3,0.017,3.059,1,1,2,1,642,69.2,8.41,1002,,1,,,nucleus,DNA binding;protein binding,"Pf03184, Pf03221, Pf04218",84948,ENSG00000179886.5; ENSG00000278016.2,TIGD5,8; CHR_HSCHR8_3_CTG7,,,,0,High,1
Q9BYK8,Helicase with zinc finger domain 2 OS=Homo sapiens OX=9606 GN=HELZ2 PE=1 SV=6,0.017,3.058,0,1,11,1,2649,294.5,7.49,4018,,1,,metabolic process;regulation of biological process,membrane;nucleus,catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding,"Pf00773, Pf04851, Pf13086, Pf13087, Pf13538",85441,ENSG00000130589.16,HELZ2,20,,,"Transcriptional regulation of white adipocyte differentiation; Activation of gene expression by SREBF (SREBP); YAP1- and WWTR1 (TAZ)-stimulated gene expression; Transcriptional activation of mitochondrial biogenesis; RORA activates gene expression; PPARA activates gene expression; BMAL1:CLOCK,NPAS2 activates circadian gene expression; RUNX3 regulates YAP1-mediated transcription",21,High,1
Q9Y4A5,Transformation/transcription domain-associated protein OS=Homo sapiens OX=9606 GN=TRRAP PE=1 SV=3,0.017,3.051,0,1,36,1,3859,437.3,8.19,11975,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,Golgi;nucleus,catalytic activity;protein binding,"Pf00454, Pf02259, Pf02260",8295,ENSG00000196367.12,TRRAP,7,HTLV-I infection,,HATs acetylate histones; Formation of the beta-catenin:TCF transactivating complex; Ub-specific processing proteases,12,High,1
Q7Z7M0,Multiple epidermal growth factor-like domains protein 8 OS=Homo sapiens OX=9606 GN=MEGF8 PE=1 SV=2,0.017,3.046,0,1,1,1,2845,302.9,6.87,283,,1,,cellular component movement;regulation of biological process;response to stimulus,membrane;nucleus,metal ion binding;protein binding,"Pf00053, Pf00431, Pf07645, Pf12947, Pf13415, Pf13418, Pf13854",1954,ENSG00000105429.12,MEGF8,19,,,,0,High,1
O15439,Multidrug resistance-associated protein 4 OS=Homo sapiens OX=9606 GN=ABCC4 PE=1 SV=3,0.017,3.046,1,1,4,1,1325,149.4,8.19,1725,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,membrane,catalytic activity;nucleotide binding;transporter activity,"Pf00005, Pf00664, Pf01926, Pf08477, Pf13191",10257,ENSG00000125257.13,ABCC4,13,Antifolate resistance; cAMP signaling pathway; ABC transporters; Bile secretion,Fluoropyrimidine Activity; Drug Induction of Bile Acid Pathway; Ectoderm Differentiation; NRF2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; TYROBP Causal Network,Platelet degranulation ; ABC-family proteins mediated transport,16,High,1
O75164,Lysine-specific demethylase 4A OS=Homo sapiens OX=9606 GN=KDM4A PE=1 SV=2,0.017,3.045,1,1,22,1,1064,120.6,5.85,7897,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;protein binding,"Pf02373, Pf02375, Pf13771, Pf13831, Pf13832",9682,ENSG00000066135.12,KDM4A,1,,,Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; HDMs demethylate histones,7,High,1
Q96N58,Zinc finger protein 578 OS=Homo sapiens OX=9606 GN=ZNF578 PE=2 SV=2,0.017,3.043,1,1,12,1,590,68.5,8.95,5350,,1,,metabolic process;regulation of biological process,cytoplasm;nucleus,DNA binding;metal ion binding,"Pf01352, Pf13465",147660,ENSG00000258405.9,ZNF578,19,,,,0,High,1
Q8N283,Ankyrin repeat domain-containing protein 35 OS=Homo sapiens OX=9606 GN=ANKRD35 PE=2 SV=2,0.017,3.042,1,1,16,1,1001,109.9,6.02,5938,,1,,,,protein binding,"Pf00023, Pf12796, Pf13606, Pf13637, Pf13857",148741,,ANKRD35,1,,,,0,High,1
O00255,Menin OS=Homo sapiens OX=9606 GN=MEN1 PE=1 SV=4,0.017,3.04,2,1,3,1,615,68,6.55,965,,1,,cell differentiation;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;cytosol;nucleus;organelle lumen,catalytic activity;DNA binding;protein binding,Pf05053,4221,ENSG00000133895.14,MEN1,11,Transcriptional misregulation in cancer,Cell Cycle,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Deactivation of the beta-catenin transactivating complex; Formation of the beta-catenin:TCF transactivating complex; RHO GTPases activate IQGAPs,21,High,1
P36021,Monocarboxylate transporter 8 OS=Homo sapiens OX=9606 GN=SLC16A2 PE=1 SV=2,0.017,3.034,2,1,1,1,539,59.5,5.59,236,,1,,transport,membrane,transporter activity,Pf07690,6567,ENSG00000147100.10,SLC16A2,X,Thyroid hormone signaling pathway,Angiopoietin Like Protein 8 Regulatory Pathway,Transport of organic anions,6,High,1
Q9BTK6,PAXIP1-associated glutamate-rich protein 1 OS=Homo sapiens OX=9606 GN=PAGR1 PE=1 SV=1,0.017,3.033,7,1,1,1,254,27.7,4.46,533,,1,,metabolic process;regulation of biological process;response to stimulus,nucleus,protein binding,Pf15364,79447,ENSG00000280789.1,PAGR1,16,,,Activation of anterior HOX genes in hindbrain development during early embryogenesis,3,High,1
Q8IYM0,Protein FAM186B OS=Homo sapiens OX=9606 GN=FAM186B PE=2 SV=2,0.017,3.032,1,1,6,1,893,103.7,9.01,2190,,1,,,,,,84070,ENSG00000135436.8,FAM186B,12,,,,0,High,1
Q9NVR2,Integrator complex subunit 10 OS=Homo sapiens OX=9606 GN=INTS10 PE=1 SV=2,0.017,3.03,2,1,8,1,710,82.2,7.44,837,,1,,metabolic process,nucleus,protein binding,,55174,ENSG00000104613.11,INTS10,8,,,RNA polymerase II transcribes snRNA genes,3,High,1
Q9Y4K4,Mitogen-activated protein kinase kinase kinase kinase 5 OS=Homo sapiens OX=9606 GN=MAP4K5 PE=1 SV=2,0.017,3.027,2,1,3,1,846,95,7.83,780,,1,,,,,,,,,,,,,0,High,1
Q96RE7,Nucleus accumbens-associated protein 1 OS=Homo sapiens OX=9606 GN=NACC1 PE=1 SV=1,0.017,3.02,2,1,3,1,527,57.2,5.74,1204,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;nucleus,protein binding,"Pf00651, Pf10523",112939,ENSG00000160877.5,NACC1,19,,,,0,High,1
Q5EB52,Mesoderm-specific transcript homolog protein OS=Homo sapiens OX=9606 GN=MEST PE=2 SV=2,0.017,3.019,2,1,4,1,335,38.8,9.74,1672,,1,,,endoplasmic reticulum;membrane,catalytic activity,"Pf00561, Pf06342, Pf12695, Pf12697",4232,ENSG00000106484.14,MEST,7,,,,0,High,1
Q6IQ26,DENN domain-containing protein 5A OS=Homo sapiens OX=9606 GN=DENND5A PE=1 SV=2,0.017,3.019,1,1,1,1,1287,147,6.65,382,,1,,regulation of biological process;response to stimulus;transport,cytosol;Golgi;membrane,protein binding;transporter activity,"Pf01477, Pf02141, Pf02759, Pf03455, Pf03456",23258,ENSG00000184014.7,DENND5A,11,,,RAB GEFs exchange GTP for GDP on RABs,4,High,1
Q9Y5J1,U3 small nucleolar RNA-associated protein 18 homolog OS=Homo sapiens OX=9606 GN=UTP18 PE=1 SV=3,0.017,3.016,3,1,3,1,556,62,8.76,1164,,1,,metabolic process,membrane;nucleus,protein binding;RNA binding,,51096,ENSG00000011260.13,UTP18,17,Ribosome biogenesis in eukaryotes,,Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol,6,High,1
Q6AZZ1,E3 ubiquitin-protein ligase TRIM68 OS=Homo sapiens OX=9606 GN=TRIM68 PE=1 SV=1,0.018,3.009,4,1,1,1,485,56.2,6.48,247,,1,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;Golgi;nucleus,catalytic activity;metal ion binding;protein binding,"Pf00097, Pf00622, Pf00643, Pf13445, Pf13639, Pf13765, Pf13920, Pf13923, Pf14835, Pf15227",55128,ENSG00000167333.12,TRIM68,11,,,Interferon gamma signaling,4,High,1
Q16627,C-C motif chemokine 14 OS=Homo sapiens OX=9606 GN=CCL14 PE=1 SV=1,0.018,3.003,9,1,1,1,93,10.7,8.72,381,,1,,cellular component movement;cellular homeostasis;defense response;regulation of biological process;response to stimulus,extracellular,protein binding,Pf00048,6358,ENSG00000277236.4; ENSG00000276409.4,CCL14,17; CHR_HSCHR17_7_CTG4,Cytokine-cytokine receptor interaction; Chemokine signaling pathway,,,2,High,1
A6NKB5,Pecanex-like protein 2 OS=Homo sapiens OX=9606 GN=PCNX2 PE=2 SV=3,0.018,3.003,1,1,2,1,2137,237.1,6.76,983,,1,,,membrane,,Pf05041,80003,ENSG00000135749.18,PCNXL2; PCNX2,1,,,,0,High,1
P27707,Deoxycytidine kinase OS=Homo sapiens OX=9606 GN=DCK PE=1 SV=1,0.018,3,4,1,2,1,260,30.5,5.21,763,,1,,metabolic process,cytosol;nucleus,catalytic activity;nucleotide binding;protein binding,Pf01712,1633,ENSG00000156136.9,DCK,4,Pyrimidine metabolism; Metabolic pathways; Purine metabolism,Retinoblastoma (RB) in Cancer,Pyrimidine salvage; Purine salvage,9,High,1
Q9P227,Rho GTPase-activating protein 23 OS=Homo sapiens OX=9606 GN=ARHGAP23 PE=1 SV=2,0.018,2.999,1,1,2,1,1491,162.1,9.19,587,,1,,regulation of biological process;response to stimulus,cytosol,enzyme regulator activity;protein binding,"Pf00169, Pf00595, Pf00620, Pf13180, Pf15410",57636,ENSG00000273780.2; ENSG00000275832.4,ARHGAP23,17; CHR_HSCHR17_7_CTG4,,,Rho GTPase cycle,3,High,1
Q15345,Leucine-rich repeat-containing protein 41 OS=Homo sapiens OX=9606 GN=LRRC41 PE=1 SV=3,0.018,2.994,1,1,2,1,812,88.6,8.38,638,,1,,metabolic process,cytoplasm;cytosol;membrane;nucleus,protein binding,,10489,ENSG00000132128.16,LRRC41,1,,,Antigen processing: Ubiquitination & Proteasome degradation; Neddylation,7,High,1
Q96HR3,Mediator of RNA polymerase II transcription subunit 30 OS=Homo sapiens OX=9606 GN=MED30 PE=1 SV=1,0.018,2.992,5,1,1,1,178,20.3,8.27,491,,1,,metabolic process;regulation of biological process;response to stimulus,nucleus,catalytic activity;protein binding;receptor activity,Pf11315,90390,ENSG00000164758.7,MED30,8,Thyroid hormone signaling pathway,,Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Generic Transcription Pathway,10,High,1
Q9C0K7,STE20-related kinase adapter protein beta OS=Homo sapiens OX=9606 GN=STRADB PE=1 SV=1,0.018,2.991,2,1,6,1,418,47,7.01,2364,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf07714",55437,ENSG00000082146.12,STRADB,2,AMPK signaling pathway; mTOR signaling pathway,AMP-activated Protein Kinase (AMPK) Signaling; mir-124 predicted interactions with cell cycle and differentiation,Energy dependent regulation of mTOR by LKB1-AMPK,7,High,1
P01033,Metalloproteinase inhibitor 1 OS=Homo sapiens OX=9606 GN=TIMP1 PE=1 SV=1,0.018,2.985,4,1,1,1,207,23.2,8.1,310,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,extracellular;organelle lumen,enzyme regulator activity;metal ion binding;protein binding,Pf00965,7076,ENSG00000102265.11,TIMP1,X,HIF-1 signaling pathway,Matrix Metalloproteinases; IL1 and megakaryocytes in obesity; Lung fibrosis; IL-6 signaling pathway,Platelet degranulation ; Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Activation of Matrix Metalloproteinases; Interleukin-10 signaling; Interleukin-4 and 13 signaling,21,High,1
Q7Z4F1,Low-density lipoprotein receptor-related protein 10 OS=Homo sapiens OX=9606 GN=LRP10 PE=1 SV=2,0.018,2.983,2,1,2,1,713,76.1,5.52,581,,1,,metabolic process;transport,membrane,protein binding;receptor activity,"Pf00057, Pf00431",26020,ENSG00000197324.8,LRP10,14,,,Signaling by GPCR; Retinoid metabolism and transport,7,High,1
O75084,Frizzled-7 OS=Homo sapiens OX=9606 GN=FZD7 PE=1 SV=2,0.018,2.979,1,1,1,1,574,63.6,7.81,293,,1,,cell differentiation;cell division;cell organization and biogenesis;development;regulation of biological process;response to stimulus,endosome;membrane,protein binding;receptor activity;signal transducer activity,"Pf01392, Pf01534",8324,ENSG00000155760.2,FZD7,2,Breast cancer; Basal cell carcinoma; Melanogenesis; Proteoglycans in cancer; Pathways in cancer; Signaling pathways regulating pluripotency of stem cells; Hippo signaling pathway; mTOR signaling pathway; Wnt signaling pathway; HTLV-I infection,Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds; Association Between Physico-Chemical Features and Toxicity Associated Pathways; ESC Pluripotency Pathways; Wnt Signaling in Kidney Disease; Wnt Signaling Pathway and Pluripotency; Wnt Signaling Pathway,Class B/2 (Secretin family receptors); Asymmetric localization of PCP proteins,24,High,1
Q9BTV5,Fibronectin type III and SPRY domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FSD1 PE=1 SV=1,0.018,2.978,1,1,3,1,496,55.8,6.99,1182,,1,,cell division,cytoplasm;cytoskeleton;nucleus,protein binding,"Pf00041, Pf00622",79187,ENSG00000105255.10,FSD1,19,,,,0,High,1
Q9NXH9,tRNA (guanine(26)-N(2))-dimethyltransferase OS=Homo sapiens OX=9606 GN=TRMT1 PE=1 SV=1,0.018,2.975,2,1,1,1,659,72.2,7.64,404,,1,,metabolic process,mitochondrion;nucleus,catalytic activity;metal ion binding;protein binding;RNA binding,"Pf00642, Pf02005, Pf02475, Pf03602, Pf12847, Pf13659",55621,ENSG00000104907.12,TRMT1,19,,,tRNA modification in the nucleus and cytosol,3,High,1
Q96EK6,Glucosamine 6-phosphate N-acetyltransferase OS=Homo sapiens OX=9606 GN=GNPNAT1 PE=1 SV=1,0.018,2.969,6,1,2,1,184,20.7,7.99,506,,1,,metabolic process,cytosol;endosome;Golgi;membrane,catalytic activity;protein binding,"Pf00583, Pf13508",64841,ENSG00000100522.8,GNPNAT1,14,Amino sugar and nucleotide sugar metabolism,,Synthesis of UDP-N-acetyl-glucosamine,7,High,1
Q5BJH2,Transmembrane protein 128 OS=Homo sapiens OX=9606 GN=TMEM128 PE=1 SV=2,0.018,2.966,8,1,1,1,165,18.8,6.76,368,,1,,,,,,,,,,,,,0,High,1
Q9Y2G9,Protein strawberry notch homolog 2 OS=Homo sapiens OX=9606 GN=SBNO2 PE=2 SV=3,0.018,2.965,1,1,1,1,1366,150.2,6.52,417,,1,,cell differentiation;metabolic process;regulation of biological process;response to stimulus,,,"Pf00271, Pf13871, Pf13872",22904,ENSG00000278788.4; ENSG00000064932.15,SBNO2,19; CHR_HSCHR19_4_CTG2,,,,0,High,1
Q8TBP5,Membrane protein FAM174A OS=Homo sapiens OX=9606 GN=FAM174A PE=2 SV=1,0.018,2.964,13,1,2,1,190,19.9,6.33,564,,1,,,membrane,,Pf06679,345757,ENSG00000174132.8,FAM174A,5,,,,0,High,1
Q9BU40,Chordin-like protein 1 OS=Homo sapiens OX=9606 GN=CHRDL1 PE=1 SV=2,0.018,2.96,3,1,4,1,456,52,8.32,809,,1,,,,,,,,,,,,,0,High,1
Q6NSX1,Coiled-coil domain-containing protein 70 OS=Homo sapiens OX=9606 GN=CCDC70 PE=1 SV=1,0.018,2.96,6,1,6,1,233,28.7,5.83,2508,,1,,,extracellular;membrane,protein binding,,83446,ENSG00000123171.6,CCDC70,13,,,,0,High,1
Q8WVD5,RING finger protein 141 OS=Homo sapiens OX=9606 GN=RNF141 PE=1 SV=1,0.018,2.958,4,1,6,1,230,25.5,5.2,2038,,1,,metabolic process;regulation of biological process,membrane,catalytic activity;DNA binding;metal ion binding;protein binding,"Pf00097, Pf12678, Pf13445, Pf13639, Pf13920, Pf13923, Pf14447, Pf14634, Pf15227",50862,ENSG00000110315.6,RNF141,11,,,,0,High,1
P02458,Collagen alpha-1(II) chain OS=Homo sapiens OX=9606 GN=COL2A1 PE=1 SV=3,0.019,2.951,1,1,5,1,1487,141.7,6.92,2345,,1,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;extracellular;organelle lumen,metal ion binding;protein binding;structural molecule activity,"Pf00093, Pf01391, Pf01410",1280,ENSG00000139219.17,COL2A1,12,Protein digestion and absorption; PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction,Neural Crest Differentiation; Spinal Cord Injury; Focal Adhesion; Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Endochondral Ossification,ECM proteoglycans; Collagen degradation; Integrin cell surface interactions; Assembly of collagen fibrils and other multimeric structures; MET activates PTK2 signaling; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Collagen chain trimerization; NCAM1 interactions; Signaling by PDGF; Non-integrin membrane-ECM interactions,33,High,1
Q9UNZ5,Leydig cell tumor 10 kDa protein homolog OS=Homo sapiens OX=9606 GN=C19orf53 PE=1 SV=1,0.019,2.947,7,1,2,1,99,10.6,11.55,866,,1,,,nucleus,,Pf09495,28974,ENSG00000104979.8,C19orf53,19,,,,0,High,1
Q9Y5W3,Krueppel-like factor 2 OS=Homo sapiens OX=9606 GN=KLF2 PE=1 SV=2,0.019,2.947,2,1,1,1,355,37.4,8.79,496,,1,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,nucleus,DNA binding;metal ion binding;protein binding,"Pf00096, Pf13465",10365,ENSG00000127528.5,KLF2,19,FoxO signaling pathway,EV release from cardiac cells and their functional effects; White fat cell differentiation,,3,High,1
Q9UBP6,tRNA (guanine-N(7)-)-methyltransferase OS=Homo sapiens OX=9606 GN=METTL1 PE=1 SV=1,0.019,2.944,4,1,3,1,276,31.5,7.64,1162,,1,,metabolic process,cytosol;nucleus,catalytic activity;protein binding;RNA binding,"Pf02390, Pf12847",4234,ENSG00000037897.16,METTL1,12,,,tRNA modification in the nucleus and cytosol,3,High,1
O94913,Pre-mRNA cleavage complex 2 protein Pcf11 OS=Homo sapiens OX=9606 GN=PCF11 PE=1 SV=3,0.019,2.941,1,1,2,1,1555,172.9,8.48,810,,1,,metabolic process,cytoplasm;mitochondrion;nucleus,protein binding;RNA binding,"Pf04818, Pf12782",51585,ENSG00000165494.11,PCF11,11,mRNA surveillance pathway,,Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs; RNA polymerase II transcribes snRNA genes; mRNA 3'-end processing; mRNA Splicing - Major Pathway,13,High,1
P08138,Tumor necrosis factor receptor superfamily member 16 OS=Homo sapiens OX=9606 GN=NGFR PE=1 SV=1,0.019,2.937,4,1,5,1,427,45.2,4.7,1686,,1,,cell death;cell differentiation;cellular component movement;defense response;development;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;cytosol;endosome;extracellular;membrane;nucleus,protein binding;receptor activity;signal transducer activity,"Pf00020, Pf00531",4804,ENSG00000064300.8,NGFR,17,Apoptosis - multiple species; Ras signaling pathway; Neurotrophin signaling pathway; PI3K-Akt signaling pathway; Transcriptional misregulation in cancer; Rap1 signaling pathway; Cytokine-cytokine receptor interaction,Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Spinal Cord Injury; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,NFG and proNGF binds to p75NTR; Ceramide signalling; Regulated proteolysis of p75NTR; NRAGE signals death through JNK; NF-kB is activated and signals survival; p75NTR negatively regulates cell cycle via SC1; Signalling by NGF; Axonal growth inhibition (RHOA activation); p75NTR recruits signalling complexes; NADE modulates death signalling; NRIF signals cell death from the nucleus; Axonal growth stimulation,28,High,1
A0A0C4DH36,Probable non-functional immunoglobulin heavy variable 3-38 OS=Homo sapiens OX=9606 GN=IGHV3-38 PE=5 SV=1,0.019,2.931,9,1,2,1,116,12.8,9.25,,4.5,,1,cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,,protein binding,,,ENSG00000282425.1; ENSG00000211958.2,,CHR_HSCHR14_3_CTG1; 14,,,,0,High,1
Q9NQG6,Mitochondrial dynamics protein MID51 OS=Homo sapiens OX=9606 GN=MIEF1 PE=1 SV=1,0.019,2.93,2,1,4,1,463,51.3,7.64,1428,,1,,cell organization and biogenesis;regulation of biological process,membrane;mitochondrion,nucleotide binding;protein binding,Pf03281,54471,ENSG00000100335.13,SMCR7L; MIEF1,22,,,,0,High,1
P00750,Tissue-type plasminogen activator OS=Homo sapiens OX=9606 GN=PLAT PE=1 SV=1,0.02,2.923,2,1,1,1,562,62.9,7.8,373,,1,,cellular component movement;coagulation;metabolic process;regulation of biological process;response to stimulus,cell surface;cytoplasm;extracellular,catalytic activity;protein binding,"Pf00039, Pf00051, Pf00089, Pf09342",5327,ENSG00000104368.17,PLAT,8,Complement and coagulation cascades; Transcriptional misregulation in cancer,Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism; Blood Clotting Cascade; NOTCH1 regulation of human endothelial cell calcification; Endochondral Ossification; Complement and Coagulation Cascades; Senescence and Autophagy in Cancer,Dissolution of Fibrin Clot; Signaling by PDGF,15,High,1
O94827,Pleckstrin homology domain-containing family G member 5 OS=Homo sapiens OX=9606 GN=PLEKHG5 PE=1 SV=3,0.02,2.917,1,1,3,1,1062,117.4,6.3,,4.59,,1,cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,signal transducer activity,"Pf00169, Pf00621",57449,ENSG00000171680.21,PLEKHG5,1,Pathways in cancer,,G alpha (12/13) signalling events; NRAGE signals death through JNK; Signalling by NGF; Rho GTPase cycle,12,High,1
Q6SPF0,Atherin OS=Homo sapiens OX=9606 GN=SAMD1 PE=1 SV=1,0.02,2.913,2,1,3,1,538,56,7.58,1532,,1,,,cytoplasm;extracellular;nucleus,DNA binding;protein binding,"Pf00536, Pf02198",90378,,SAMD1,19,,,,0,High,1
Q5VTE6,Protein angel homolog 2 OS=Homo sapiens OX=9606 GN=ANGEL2 PE=2 SV=1,0.02,2.908,3,1,1,1,544,62.3,7.81,199,,1,,regulation of biological process,cytoplasm,RNA binding,Pf03372,90806,ENSG00000174606.13,ANGEL2,1,,,,0,High,1
Q9UPZ3,Hermansky-Pudlak syndrome 5 protein OS=Homo sapiens OX=9606 GN=HPS5 PE=1 SV=2,0.02,2.898,1,1,4,1,1129,127.4,5.54,1601,,1,,cell organization and biogenesis;coagulation,cytoplasm;cytosol,protein binding,,11234,ENSG00000110756.17,HPS5,11,,,,0,High,1
Q8N2U9,Solute carrier family 66 member 2 OS=Homo sapiens OX=9606 GN=SLC66A2 PE=1 SV=1,0.02,2.894,4,1,2,1,271,30.5,8.18,641,,1,,,membrane,,Pf04193,80148,ENSG00000122490.18,PQLC1,18,,,,0,High,1
P49642,DNA primase small subunit OS=Homo sapiens OX=9606 GN=PRIM1 PE=1 SV=1,0.02,2.89,2,1,2,1,420,49.9,8.21,1006,,1,,cell organization and biogenesis;cellular homeostasis;metabolic process,membrane,catalytic activity;DNA binding;metal ion binding,Pf01896,5557,ENSG00000198056.13,PRIM1,12,Metabolic pathways; DNA replication; Pyrimidine metabolism; Purine metabolism,Retinoblastoma (RB) in Cancer; G1 to S cell cycle control; DNA Replication,Activation of the pre-replicative complex; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Polymerase switching; M/G1 Transition; DNA replication initiation; Polymerase switching on the C-strand of the telomere; Removal of the Flap Intermediate; Telomere C-strand synthesis initiation,32,High,1
Q9H082,Ras-related protein Rab-33B OS=Homo sapiens OX=9606 GN=RAB33B PE=1 SV=1,0.02,2.89,5,1,1,1,229,25.7,7.18,278,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,Golgi;membrane;organelle lumen,catalytic activity;nucleotide binding;protein binding;signal transducer activity,"Pf00025, Pf00071, Pf00503, Pf01926, Pf04670, Pf08477",83452,ENSG00000172007.5,RAB33B,4,,,TBC/RABGAPs; Intra-Golgi traffic; RAB geranylgeranylation,9,High,1
Q6DKI1,60S ribosomal protein L7-like 1 OS=Homo sapiens OX=9606 GN=RPL7L1 PE=1 SV=2,0.02,2.888,3,1,3,1,255,29.7,10.52,1082,,1,,,,,,,,,,,,,0,High,1
Q99758,ATP-binding cassette sub-family A member 3 OS=Homo sapiens OX=9606 GN=ABCA3 PE=1 SV=2,0.02,2.886,0,1,1,1,1704,191.2,7.62,327,,1,,metabolic process;response to stimulus;transport,membrane,catalytic activity;nucleotide binding;transporter activity,"Pf00005, Pf03193, Pf12698, Pf13304, Pf13476",21,ENSG00000167972.13,ABCA3,16,ABC transporters,,Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3); Defective ABCA3 causes pulmonary surfactant metabolism dysfunction 3 (SMDP3); ABC transporters in lipid homeostasis; Surfactant metabolism,13,High,1
Q9Y6R0,Numb-like protein OS=Homo sapiens OX=9606 GN=NUMBL PE=1 SV=1,0.02,2.886,5,1,5,1,609,64.9,8.85,590,,1,,cell division;cell organization and biogenesis;cell proliferation;development;metabolic process;regulation of biological process;response to stimulus,cytoplasm,protein binding,"Pf00640, Pf06311, Pf08416",9253,ENSG00000105245.9,NUMBL,19,Notch signaling pathway,Notch Signaling Pathway; Notch Signaling Pathway,,3,High,1
Q9Y314,Nitric oxide synthase-interacting protein OS=Homo sapiens OX=9606 GN=NOSIP PE=1 SV=1,0.02,2.879,5,1,1,1,301,33.2,8.82,304,,1,,development;metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;nucleus,catalytic activity;metal ion binding;protein binding;RNA binding,"Pf04564, Pf04641, Pf11789",51070,ENSG00000142546.13,NOSIP,19,,,NOSIP mediated eNOS trafficking,4,High,1
Q9H1Z9,Tetraspanin-10 OS=Homo sapiens OX=9606 GN=TSPAN10 PE=2 SV=1,0.02,2.875,2,1,30,1,355,36.5,5.86,11235,,1,,regulation of biological process;response to stimulus,membrane,protein binding,Pf00335,83882,,TSPAN10,17,,,,0,High,1
P23508,Colorectal mutant cancer protein OS=Homo sapiens OX=9606 GN=MCC PE=1 SV=2,0.02,2.872,2,1,1,1,829,93,5.52,384,,1,,regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,protein binding;receptor activity,"Pf04156, Pf10506",4163,ENSG00000171444.17,MCC,5,,,,0,High,1
Q2TBA0,Kelch-like protein 40 OS=Homo sapiens OX=9606 GN=KLHL40 PE=1 SV=2,0.02,2.87,2,1,3,1,621,69.2,5.27,1385,,1,,cell differentiation;development;metabolic process;regulation of biological process,cytoplasm,catalytic activity;protein binding,"Pf00651, Pf01344, Pf07707, Pf13415, Pf13418, Pf13964",131377,ENSG00000157119.11,KBTBD5; KLHL40,3,,,,0,High,1
Q9H579,Protein MROH8 OS=Homo sapiens OX=9606 GN=MROH8 PE=2 SV=2,0.02,2.866,1,1,10,1,483,54.8,6.4,3088,,1,,,,,,140699,,C20orf132; MROH8,20,,,,0,High,1
Q8WVX9,Fatty acyl-CoA reductase 1 OS=Homo sapiens OX=9606 GN=FAR1 PE=1 SV=1,0.02,2.859,3,1,1,1,515,59.3,9.17,320,,1,,metabolic process,membrane;organelle lumen,catalytic activity,"Pf01370, Pf03015, Pf07993",84188,ENSG00000197601.12,FAR1,11,Peroxisome,,Wax biosynthesis,4,High,1
O60487,Myelin protein zero-like protein 2 OS=Homo sapiens OX=9606 GN=MPZL2 PE=1 SV=1,0.02,2.859,6,1,1,1,215,24.5,7.02,369,,1,,,cytoskeleton;membrane,protein binding,"Pf07679, Pf07686",10205,ENSG00000149573.8,MPZL2,11,,Differentiation of white and brown adipocyte,,1,High,1
O15347,High mobility group protein B3 OS=Homo sapiens OX=9606 GN=HMGB3 PE=1 SV=4,0.02,2.856,7,1,2,1,200,23,8.37,484,,1,,defense response;development;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;nucleus,DNA binding;protein binding;RNA binding,"Pf00505, Pf09011",3149,ENSG00000029993.14,HMGB3,X,,,,0,High,1
Q9Y294,Histone chaperone ASF1A OS=Homo sapiens OX=9606 GN=ASF1A PE=1 SV=1,0.02,2.852,12,1,2,1,204,23,4.41,678,,1,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,nucleus,protein binding,Pf04729,25842,ENSG00000111875.7,ASF1A,6,,,Formation of Senescence-Associated Heterochromatin Foci (SAHF),5,High,1
Q9P206,Uncharacterized protein KIAA1522 OS=Homo sapiens OX=9606 GN=KIAA1522 PE=1 SV=2,0.02,2.846,1,1,1,1,1035,107,9.73,304,,1,,cell differentiation,,,,57648,ENSG00000162522.10,KIAA1522,1,,,,0,High,1
Q8IY37,Probable ATP-dependent RNA helicase DHX37 OS=Homo sapiens OX=9606 GN=DHX37 PE=1 SV=1,0.02,2.844,1,1,1,1,1157,129.5,8.1,272,,1,,metabolic process,cytoplasm,catalytic activity;nucleotide binding;RNA binding,"Pf00270, Pf00271, Pf04408, Pf07717, Pf13401",57647,ENSG00000150990.7,DHX37,12,,,Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol,5,High,1
Q9NQX7,Integral membrane protein 2C OS=Homo sapiens OX=9606 GN=ITM2C PE=1 SV=1,0.021,2.834,8,1,1,1,267,30.2,8,305,,1,,cell differentiation;regulation of biological process,Golgi;membrane;vacuole,nucleotide binding;protein binding,Pf04089,81618,ENSG00000135916.15,ITM2C,2,,,,0,High,1
Q9NRQ2,Phospholipid scramblase 4 OS=Homo sapiens OX=9606 GN=PLSCR4 PE=1 SV=2,0.021,2.834,4,1,1,1,329,37,5.82,355,,1,,cell organization and biogenesis;response to stimulus,membrane,metal ion binding;protein binding;transporter activity,Pf03803,57088,ENSG00000114698.14,PLSCR4,3,,,,0,High,1
Q04724,Transducin-like enhancer protein 1 OS=Homo sapiens OX=9606 GN=TLE1 PE=1 SV=2,0.021,2.833,1,1,1,1,770,83.1,7.24,251,,1,,development;metabolic process;regulation of biological process;response to stimulus,cytosol;nucleus,protein binding,"Pf00400, Pf03920",7088,ENSG00000196781.14,TLE1,9,,Notch Signaling Pathway,NOTCH1 Intracellular Domain Regulates Transcription; Repression of WNT target genes; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex,11,High,1
Q16760,Diacylglycerol kinase delta OS=Homo sapiens OX=9606 GN=DGKD PE=1 SV=4,0.021,2.832,2,1,1,1,1214,134.4,7.56,177,,1,,cell growth;cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;membrane;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00130, Pf00169, Pf00536, Pf00609, Pf00781, Pf07647, Pf15413",8527,ENSG00000280873.3; ENSG00000077044.10,DGKD,2; CHR_HG2232_PATCH,Glycerolipid metabolism; Glycerophospholipid metabolism; Phosphatidylinositol signaling system; Phospholipase D signaling pathway; Metabolic pathways; Choline metabolism in cancer,,Effects of PIP2 hydrolysis; Gastrin-CREB signalling pathway via PKC and MAPK,14,High,1
Q96JB1,"Dynein heavy chain 8, axonemal OS=Homo sapiens OX=9606 GN=DNAH8 PE=1 SV=2",0.021,2.83,0,1,2,1,4490,514.3,6.32,605,,1,,cell organization and biogenesis;cellular component movement,cytoplasm;cytoskeleton,catalytic activity;motor activity;nucleotide binding;protein binding,"Pf03028, Pf07728, Pf08385, Pf08393, Pf12774, Pf12775, Pf12777, Pf12780, Pf12781",1769,ENSG00000124721.17,DNAH8,6,Huntington's disease,,,1,High,1
P12273,Prolactin-inducible protein OS=Homo sapiens OX=9606 GN=PIP PE=1 SV=1,0.021,2.827,5,1,1,1,146,16.6,8.05,304,,1,,metabolic process;regulation of biological process;response to stimulus;transport,extracellular;membrane;nucleus,catalytic activity;protein binding,Pf05326,5304,ENSG00000159763.3,PIP,7,,,Miscellaneous transport and binding events,2,High,1
Q8WU17,E3 ubiquitin-protein ligase RNF139 OS=Homo sapiens OX=9606 GN=RNF139 PE=1 SV=1,0.021,2.826,1,1,3,1,664,75.9,6.44,1305,,1,,metabolic process;regulation of biological process,endoplasmic reticulum;membrane,catalytic activity;metal ion binding;protein binding;receptor activity,"Pf00097, Pf11793, Pf12678, Pf12861, Pf13639, Pf13705, Pf13920, Pf13923, Pf14634",11236,ENSG00000170881.4,RNF139,8,,Sterol Regulatory Element-Binding Proteins (SREBP) signalling,ER Quality Control Compartment (ERQC),7,High,1
Q9NNZ3,DnaJ homolog subfamily C member 4 OS=Homo sapiens OX=9606 GN=DNAJC4 PE=1 SV=1,0.021,2.822,7,1,2,1,241,27.6,10.55,,6.91,,1,metabolic process;response to stimulus,membrane,protein binding,Pf00226,3338,ENSG00000110011.13,DNAJC4,11,,,,0,High,1
Q9HAR2,Adhesion G protein-coupled receptor L3 OS=Homo sapiens OX=9606 GN=ADGRL3 PE=1 SV=2,0.021,2.82,1,1,17,1,1447,161.7,6.44,6559,,1,,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,membrane,metal ion binding;protein binding;receptor activity;signal transducer activity,"Pf00002, Pf01825, Pf02140, Pf02191, Pf02354, Pf02793, Pf12003",23284,,LPHN3; ADGRL3,4,,"GPCRs, Other; GPCRs, Class B Secretin-like",,2,High,1
Q7L5Y9,E3 ubiquitin-protein transferase MAEA OS=Homo sapiens OX=9606 GN=MAEA PE=1 SV=1,0.021,2.817,2,1,1,1,396,45.3,8.69,410,,1,,cell division;cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytoskeleton;membrane;nucleus,catalytic activity;protein binding,Pf10607,10296,ENSG00000090316.15,MAEA,4,,,,0,High,1
Q6SJ96,TATA box-binding protein-like protein 2 OS=Homo sapiens OX=9606 GN=TBPL2 PE=2 SV=1,0.021,2.817,2,1,48,1,375,41.5,6.43,15493,,1,,development;metabolic process;regulation of biological process,cytoplasm;nucleus,DNA binding,Pf00352,387332,ENSG00000182521.5,TBPL2,14,Basal transcription factors; HTLV-I infection; Epstein-Barr virus infection; Viral carcinogenesis; Herpes simplex infection; Huntington's disease,,,6,High,1
Q9NVQ4,Fas apoptotic inhibitory molecule 1 OS=Homo sapiens OX=9606 GN=FAIM PE=1 SV=1,0.021,2.817,4,1,2,1,179,20.2,5.83,587,,1,,cell death;regulation of biological process,cytoplasm,protein binding,Pf06905,55179,ENSG00000158234.12,FAIM,3,,,,0,High,1
O15234,Protein CASC3 OS=Homo sapiens OX=9606 GN=CASC3 PE=1 SV=2,0.021,2.814,1,1,1,1,703,76.2,6.48,380,,1,,metabolic process;regulation of biological process;transport,cytoplasm;cytosol;membrane;nucleus,protein binding;RNA binding,Pf09405,22794,ENSG00000108349.16,CASC3,17,mRNA surveillance pathway; RNA transport,,mRNA 3'-end processing; mRNA Splicing - Major Pathway; Cleavage of Growing Transcript in the Termination Region ; Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC),19,High,1
Q96GX1,Tectonic-2 OS=Homo sapiens OX=9606 GN=TCTN2 PE=2 SV=1,0.021,2.812,1,1,1,1,697,76.8,5.24,521,,1,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;membrane,,Pf07773,79867,ENSG00000168778.11,TCTN2,12,,,Anchoring of the basal body to the plasma membrane,3,High,1
Q9Y5S1,Transient receptor potential cation channel subfamily V member 2 OS=Homo sapiens OX=9606 GN=TRPV2 PE=1 SV=1,0.021,2.811,1,1,2,1,764,85.9,5.83,631,,1,,regulation of biological process;response to stimulus;transport,cell surface;cytoplasm;membrane,protein binding;transporter activity,"Pf00023, Pf12796, Pf13606, Pf13637, Pf13857",51393,ENSG00000187688.14,TRPV2,17,NOD-like receptor signaling pathway; Inflammatory mediator regulation of TRP channels,,TRP channels,6,High,1
Q01650,Large neutral amino acids transporter small subunit 1 OS=Homo sapiens OX=9606 GN=SLC7A5 PE=1 SV=2,0.021,2.806,1,1,6,1,507,55,7.72,2431,,1,,cell differentiation;cellular component movement;development;metabolic process;transport,cytoplasm;cytosol;membrane,protein binding;transporter activity,"Pf00324, Pf13520",8140,ENSG00000103257.8,SLC7A5,16,Central carbon metabolism in cancer; mTOR signaling pathway,Aryl Hydrocarbon Receptor Pathway,Tryptophan catabolism; Basigin interactions; Amino acid transport across the plasma membrane,14,High,1
Q9NX57,Ras-related protein Rab-20 OS=Homo sapiens OX=9606 GN=RAB20 PE=1 SV=1,0.021,2.805,4,1,1,1,234,26.3,6.55,393,,1,,cell organization and biogenesis;cellular homeostasis;regulation of biological process;response to stimulus;transport,endosome;Golgi;membrane,catalytic activity;nucleotide binding,"Pf00025, Pf00071, Pf08477",55647,ENSG00000139832.4,RAB20,13,,,RAB geranylgeranylation,3,High,1
Q9BVA0,Katanin p80 WD40 repeat-containing subunit B1 OS=Homo sapiens OX=9606 GN=KATNB1 PE=1 SV=1,0.021,2.802,1,1,5,1,655,72.3,7.56,1559,,1,,cell division;regulation of biological process;transport,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,catalytic activity;protein binding,"Pf00400, Pf08662, Pf08801, Pf13925",10300,ENSG00000140854.12,KATNB1,16,,,,0,High,1
Q92576,PHD finger protein 3 OS=Homo sapiens OX=9606 GN=PHF3 PE=1 SV=3,0.021,2.802,0,1,3,1,2039,229.3,6.96,993,,1,,development;metabolic process,,metal ion binding;protein binding,"Pf00628, Pf07500, Pf07744",23469,ENSG00000118482.11,PHF3,6,,,,0,High,1
Q96L73,"Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific OS=Homo sapiens OX=9606 GN=NSD1 PE=1 SV=1",0.021,2.802,1,1,2,1,2696,296.5,8.03,258,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,chromosome;nucleus,catalytic activity;DNA binding;metal ion binding;protein binding,"Pf00628, Pf00855, Pf00856",64324,ENSG00000165671.19,NSD1,5,Lysine degradation,Histone Modifications; Pathways Affected in Adenoid Cystic Carcinoma,PKMTs methylate histone lysines,6,High,1
P78346,Ribonuclease P protein subunit p30 OS=Homo sapiens OX=9606 GN=RPP30 PE=1 SV=1,0.021,2.801,6,1,2,1,268,29.3,8.91,594,,1,,metabolic process,nucleus,catalytic activity;protein binding;RNA binding,Pf01876,10556,ENSG00000148688.13,RPP30,10,RNA transport; Ribosome biogenesis in eukaryotes,,Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus,8,High,1
A4FU49,SH3 domain-containing protein 21 OS=Homo sapiens OX=9606 GN=SH3D21 PE=2 SV=2,0.021,2.796,2,1,6,1,640,70.5,5.76,2309,,1,,,membrane;nucleus,protein binding,"Pf00018, Pf07653, Pf14604",79729,,SH3D21,1,,,,0,High,1
Q8TF65,PDZ domain-containing protein GIPC2 OS=Homo sapiens OX=9606 GN=GIPC2 PE=1 SV=1,0.021,2.794,5,1,4,1,315,34.3,6.46,1185,,1,,,cytoplasm,protein binding,Pf00595,54810,ENSG00000137960.5,GIPC2,1,,,,0,High,1
O43524,Forkhead box protein O3 OS=Homo sapiens OX=9606 GN=FOXO3 PE=1 SV=1,0.021,2.794,5,1,1,1,673,71.2,5.16,225,,1,,cell death;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;mitochondrion;nucleus,DNA binding;protein binding,Pf00250,2309,ENSG00000118689.14,FOXO3,6,Endometrial cancer; Longevity regulating pathway - multiple species; AMPK signaling pathway; Neurotrophin signaling pathway; PI3K-Akt signaling pathway; FoxO signaling pathway; Chemokine signaling pathway; EGFR tyrosine kinase inhibitor resistance; Non-small cell lung cancer; Prolactin signaling pathway; Longevity regulating pathway,"IL-5 Signaling Pathway; Energy Metabolism; Signaling Pathways in Glioblastoma; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Spinal Cord Injury; Kit receptor signaling pathway; Copper homeostasis; NAD metabolism, sirtuins and aging; Imatinib and Chronic Myeloid Leukemia; Pathways Affected in Adenoid Cystic Carcinoma; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; VEGFA-VEGFR2 Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; Chemokine signaling pathway; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Insulin Signaling; IL-2 Signaling Pathway; DNA Damage Response (only ATM dependent)",Signaling by NODAL; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; AKT phosphorylates targets in the nucleus; RUNX3 regulates BCL2L11 (BIM) transcription; MAPK6/MAPK4 signaling; Interleukin-4 and 13 signaling; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Interleukin-12 family signaling; Constitutive Signaling by AKT1 E17K in Cancer,54,High,1
P50613,Cyclin-dependent kinase 7 OS=Homo sapiens OX=9606 GN=CDK7 PE=1 SV=1,0.021,2.785,6,1,2,1,346,39,8.47,484,,1,,cell division;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf07714, Pf14531",1022,ENSG00000277273.5; ENSG00000134058.11,CDK7,5; CHR_HSCHR5_2_CTG1_1,Nucleotide excision repair; Basal transcription factors; Cell cycle,MicroRNAs in cardiomyocyte hypertrophy; Integrated Breast Cancer Pathway; Cardiac Hypertrophic Response; Eukaryotic Transcription Initiation; G1 to S cell cycle control,RNA polymerase II transcribes snRNA genes; NoRC negatively regulates rRNA expression; Cyclin A:Cdk2-associated events at S phase entry; Formation of HIV-1 elongation complex containing HIV-1 Tat; Formation of Incision Complex in GG-NER; Formation of the HIV-1 Early Elongation Complex; TP53 Regulates Transcription of DNA Repair Genes; HIV Transcription Initiation; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; Formation of HIV elongation complex in the absence of HIV Tat; RNA Polymerase II HIV Promoter Escape; Gap-filling DNA repair synthesis and ligation in TC-NER; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RNA Polymerase I Chain Elongation; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; Cyclin D associated events in G1; Formation of TC-NER Pre-Incision Complex; RNA Polymerase I Promoter Escape; Cyclin A/B1/B2 associated events during G2/M transition; RNA Polymerase II Promoter Escape; RNA Pol II CTD phosphorylation and interaction with CE; Cyclin E associated events during G1/S transition ; RNA Polymerase I Transcription Termination; RNA Polymerase II Transcription Initiation; mRNA Capping; Dual incision in TC-NER; RNA Polymerase I Transcription Initiation; Formation of the Early Elongation Complex,70,High,1
Q8N5A5,Zinc finger CCCH-type with G patch domain-containing protein OS=Homo sapiens OX=9606 GN=ZGPAT PE=1 SV=3,0.021,2.785,2,1,2,1,531,57.3,5.43,697,,1,,metabolic process;regulation of biological process,membrane;nucleus,DNA binding;metal ion binding;protein binding,"Pf00642, Pf01585",84619,ENSG00000197114.11,ZGPAT,20,,,,0,High,1
O60733,85/88 kDa calcium-independent phospholipase A2 OS=Homo sapiens OX=9606 GN=PLA2G6 PE=1 SV=2,0.021,2.783,2,1,2,1,806,89.8,7.27,462,,1,,cellular homeostasis;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;mitochondrion,catalytic activity;protein binding,"Pf00023, Pf01734, Pf12796, Pf13606, Pf13637, Pf13857",8398,ENSG00000184381.18,PLA2G6,22,Inflammatory mediator regulation of TRP channels; Vascular smooth muscle contraction; Fc gamma R-mediated phagocytosis; Linoleic acid metabolism; Ras signaling pathway; Glycerophospholipid metabolism; Arachidonic acid metabolism; Metabolic pathways; Ether lipid metabolism; alpha-Linolenic acid metabolism,Eicosanoid Synthesis; Spinal Cord Injury,COPI-independent Golgi-to-ER retrograde traffic; Acyl chain remodeling of CL; Acyl chain remodelling of PE; Role of phospholipids in phagocytosis; Acyl chain remodelling of PC,28,High,1
Q6ZN66,Guanylate-binding protein 6 OS=Homo sapiens OX=9606 GN=GBP6 PE=2 SV=1,0.021,2.781,1,1,4,1,633,72.4,6.37,1957,,1,,defense response;response to stimulus,,catalytic activity;nucleotide binding,"Pf02263, Pf02841, Pf05879, Pf10359",163351,ENSG00000183347.14,GBP6,1,,,Interferon gamma signaling,4,High,1
P01130,Low-density lipoprotein receptor OS=Homo sapiens OX=9606 GN=LDLR PE=1 SV=1,0.021,2.779,2,1,1,1,860,95.3,5.05,206,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;endosome;Golgi;membrane;vacuole,metal ion binding;protein binding;receptor activity,"Pf00057, Pf00058, Pf06247, Pf07645, Pf12662, Pf14670",3949,ENSG00000130164.13,LDLR,19,Ovarian steroidogenesis; Hepatitis C; Bile secretion; Aldosterone synthesis and secretion; Toxoplasmosis; Endocytosis,Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism; Sterol Regulatory Element-Binding Proteins (SREBP) signalling; SREBF and miR33 in cholesterol and lipid homeostasis; Oncostatin M Signaling Pathway; Proprotein convertase subtilisin/kexin type 9 (PCSK9) mediated LDL receptor degradation; Evolocumab Mechanism; Composition of Lipid Particles; Wnt Signaling Pathway and Pluripotency; Wnt Signaling Pathway; Statin Pathway; DNA Damage Response (only ATM dependent),Signaling by GPCR; Cargo recognition for clathrin-mediated endocytosis; Retinoid metabolism and transport; LDL clearance; Chylomicron clearance,35,High,1
Q5VWN6,Protein TASOR 2 OS=Homo sapiens OX=9606 GN=TASOR2 PE=1 SV=1,0.021,2.779,0,1,8,1,2430,268.7,5.9,3285,,1,,,,protein binding,"Pf12480, Pf12509",54906,ENSG00000108021.19,FAM208B,10,,,,0,High,1
Q92830,Histone acetyltransferase KAT2A OS=Homo sapiens OX=9606 GN=KAT2A PE=1 SV=3,0.021,2.778,1,1,8,1,837,93.9,9.04,2445,,1,,cell differentiation;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus,nucleus,catalytic activity;protein binding,"Pf00439, Pf00583, Pf06466, Pf13508, Pf13673",2648,ENSG00000108773.10,KAT2A,17,Notch signaling pathway; Thyroid hormone signaling pathway; HTLV-I infection; Viral carcinogenesis,Notch Signaling Pathway,NOTCH1 Intracellular Domain Regulates Transcription; Ub-specific processing proteases; HATs acetylate histones; Notch-HLH transcription pathway; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Constitutive Signaling by NOTCH1 PEST Domain Mutants; RUNX3 regulates NOTCH signaling; Pre-NOTCH Transcription and Translation; B-WICH complex positively regulates rRNA expression; RNA Polymerase I Transcription Initiation,37,High,1
Q9H4H8,Protein FAM83D OS=Homo sapiens OX=9606 GN=FAM83D PE=1 SV=3,0.021,2.774,1,1,5,1,585,64.4,6.54,1555,,1,,cell division;cell organization and biogenesis;cell proliferation;cellular component movement;regulation of biological process,cytoplasm;cytoskeleton,protein binding,"Pf07894, Pf13091",81610,ENSG00000101447.14,FAM83D,20,,,,0,High,1
P10720,Platelet factor 4 variant OS=Homo sapiens OX=9606 GN=PF4V1 PE=1 SV=1,0.021,2.771,9,1,7,1,104,11.5,9.1,2051,,1,,cellular component movement;defense response;regulation of biological process;response to stimulus,extracellular,protein binding,Pf00048,5197,ENSG00000109272.3,PF4V1,4,Cytokine-cytokine receptor interaction; Chemokine signaling pathway,,Common Pathway of Fibrin Clot Formation; Cell surface interactions at the vascular wall,6,High,1
Q7L590,Protein MCM10 homolog OS=Homo sapiens OX=9606 GN=MCM10 PE=1 SV=2,0.021,2.771,1,1,2,1,875,98.1,8.75,1211,,1,,cell proliferation;metabolic process;response to stimulus,nucleus,DNA binding;metal ion binding;protein binding,"Pf09329, Pf09332",55388,ENSG00000065328.16,MCM10,10,,Cell Cycle; DNA Replication,M/G1 Transition; Activation of the pre-replicative complex; Regulation of DNA replication; Activation of ATR in response to replication stress; Removal of licensing factors from origins,15,High,1
Q9BQQ3,Golgi reassembly-stacking protein 1 OS=Homo sapiens OX=9606 GN=GORASP1 PE=1 SV=3,0.021,2.766,2,1,1,1,440,46.5,4.5,311,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,Golgi;membrane,protein binding,"Pf04495, Pf13180",64689,ENSG00000114745.13,GORASP1,3,,,COPII (Coat Protein 2) Mediated Vesicle Transport; COPI-mediated anterograde transport; Golgi Cisternae Pericentriolar Stack Reorganization,14,High,1
Q9Y227,Ectonucleoside triphosphate diphosphohydrolase 4 OS=Homo sapiens OX=9606 GN=ENTPD4 PE=1 SV=1,0.021,2.765,3,1,1,1,616,70.2,8.29,231,,1,,metabolic process,Golgi;membrane,catalytic activity,Pf01150,9583,ENSG00000197217.12,ENTPD4,8,Purine metabolism; Pyrimidine metabolism; Lysosome,,Phosphate bond hydrolysis by NTPDase proteins,7,High,1
Q6A163,"Keratin, type I cytoskeletal 39 OS=Homo sapiens OX=9606 GN=KRT39 PE=1 SV=2",0.021,2.762,1,1,8,1,491,55.6,5.26,3055,,1,,cell death;regulation of biological process,cytosol,catalytic activity;motor activity;structural molecule activity,"Pf00038, Pf01576, Pf02463, Pf05557, Pf05622, Pf12128",390792,ENSG00000196859.7; ENSG00000262164.6,KRT39,17; CHR_HSCHR17_4_CTG4,,,Formation of the cornified envelope,3,High,1
Q9Y5T5,Ubiquitin carboxyl-terminal hydrolase 16 OS=Homo sapiens OX=9606 GN=USP16 PE=1 SV=1,0.021,2.761,2,1,2,1,823,93.5,6.93,514,,1,,cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,catalytic activity;metal ion binding;protein binding,"Pf00443, Pf02148, Pf13423",10600,ENSG00000156256.14,USP16,21,,,Ub-specific processing proteases,4,High,1
O94898,Leucine-rich repeats and immunoglobulin-like domains protein 2 OS=Homo sapiens OX=9606 GN=LRIG2 PE=2 SV=3,0.021,2.756,1,1,2,1,1065,118.9,5.55,776,,1,,regulation of biological process,cytoplasm;membrane,protein binding,"Pf00047, Pf07679, Pf07686, Pf12799, Pf13306, Pf13855, Pf13895, Pf13927",9860,ENSG00000198799.11,LRIG2,1,,,,0,High,1
Q15758,Neutral amino acid transporter B(0) OS=Homo sapiens OX=9606 GN=SLC1A5 PE=1 SV=2,0.021,2.753,4,1,3,1,541,56.6,5.48,1377,,1,,transport,membrane,protein binding;receptor activity;transporter activity,Pf00375,6510,ENSG00000105281.12,SLC1A5,19,Central carbon metabolism in cancer; Protein digestion and absorption,TYROBP Causal Network,Amino acid transport across the plasma membrane,7,High,1
Q6UB98,Ankyrin repeat domain-containing protein 12 OS=Homo sapiens OX=9606 GN=ANKRD12 PE=1 SV=3,0.021,2.75,1,1,3,1,2062,235.5,7.01,783,,1,,,cytosol;nucleus,protein binding,"Pf00023, Pf12796, Pf13606, Pf13637, Pf13857",23253,ENSG00000101745.16,ANKRD12,18,,,,0,High,1
Q9Y4W2,Ribosomal biogenesis protein LAS1L OS=Homo sapiens OX=9606 GN=LAS1L PE=1 SV=2,0.021,2.749,1,1,1,1,734,83,4.73,506,,1,,cell organization and biogenesis;metabolic process,cytoplasm;membrane;nucleus,RNA binding,Pf04031,81887,ENSG00000001497.16,LAS1L,X,,,Major pathway of rRNA processing in the nucleolus and cytosol,4,High,1
Q6P9H4,Connector enhancer of kinase suppressor of ras 3 OS=Homo sapiens OX=9606 GN=CNKSR3 PE=1 SV=1,0.021,2.745,3,1,1,1,555,61.9,8.73,,0,,1,regulation of biological process,cytoplasm;membrane,protein binding,"Pf00536, Pf00595, Pf06663, Pf07647, Pf10534",154043,ENSG00000153721.18,CNKSR3,6,,,,0,High,1
Q6YHU6,Thyroid adenoma-associated protein OS=Homo sapiens OX=9606 GN=THADA PE=1 SV=1,0.021,2.743,1,1,1,1,1953,219.5,6.06,386,,1,,cellular homeostasis;regulation of biological process,,protein binding,Pf10350,63892,ENSG00000115970.18,THADA,2,,,tRNA modification in the nucleus and cytosol,3,High,1
O60462,Neuropilin-2 OS=Homo sapiens OX=9606 GN=NRP2 PE=1 SV=3,0.021,2.743,1,1,2,1,931,104.8,5.17,764,,1,,cell growth;cellular component movement;regulation of biological process;response to stimulus,extracellular;membrane,catalytic activity;metal ion binding;protein binding;receptor activity;signal transducer activity,"Pf00431, Pf00629, Pf00754, Pf11980",8828,ENSG00000118257.16,NRP2,2,,VEGFA-VEGFR2 Signaling Pathway,,1,High,1
O60512,"Beta-1,4-galactosyltransferase 3 OS=Homo sapiens OX=9606 GN=B4GALT3 PE=1 SV=2",0.021,2.741,2,1,59,1,393,43.9,9.25,20504,,1,,metabolic process,cytosol;Golgi;membrane,catalytic activity;metal ion binding,"Pf02709, Pf10111, Pf13733",8703,ENSG00000158850.14,B4GALT3,1,Glycosaminoglycan biosynthesis - keratan sulfate; N-Glycan biosynthesis; Other types of O-glycan biosynthesis; Metabolic pathways; Glycosphingolipid biosynthesis - lacto and neolacto series,,Keratan sulfate biosynthesis; N-Glycan antennae elongation,16,High,1
Q9NZJ4,Sacsin OS=Homo sapiens OX=9606 GN=SACS PE=1 SV=2,0.022,2.74,0,1,1,1,4579,520.8,7.05,280,,1,,metabolic process;regulation of biological process,cytoplasm;mitochondrion;nucleus,protein binding,"Pf00240, Pf05168",26278,ENSG00000151835.14,SACS,13,,,,0,High,1
Q9UKX7,Nuclear pore complex protein Nup50 OS=Homo sapiens OX=9606 GN=NUP50 PE=1 SV=2,0.022,2.737,2,1,3,1,468,50.1,7.06,1315,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,membrane;nucleus,protein binding,"Pf00638, Pf08911",10762,ENSG00000093000.18,NUP50,22,RNA transport,,Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; NEP/NS2 Interacts with the Cellular Export Machinery; tRNA processing in the nucleus; Transcriptional regulation by small RNAs; Nuclear Pore Complex (NPC) Disassembly; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; Transport of the SLBP independent Mature mRNA; SUMOylation of RNA binding proteins; Viral Messenger RNA Synthesis; SUMOylation of chromatin organization proteins; Nuclear import of Rev protein;  NS1 Mediated Effects on Host Pathways; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of the SLBP Dependant Mature mRNA; Transport of Ribonucleoproteins into the Host Nucleus; Transport of Mature mRNA derived from an Intron-Containing Transcript; SUMOylation of DNA damage response and repair proteins,64,High,1
Q6ZV73,"FYVE, RhoGEF and PH domain-containing protein 6 OS=Homo sapiens OX=9606 GN=FGD6 PE=1 SV=2",0.022,2.731,1,1,11,1,1430,160.7,7.03,4149,,1,,cell organization and biogenesis;regulation of biological process,cytoplasm;cytoskeleton;Golgi,metal ion binding;protein binding,"Pf00169, Pf00621, Pf01363, Pf15410, Pf15413",55785,ENSG00000180263.13,FGD6,12,,,,0,High,1
Q9BRR9,Rho GTPase-activating protein 9 OS=Homo sapiens OX=9606 GN=ARHGAP9 PE=1 SV=2,0.022,2.726,2,1,2,1,750,83.2,8.34,,4.57,,1,regulation of biological process;response to stimulus;transport,cytosol;extracellular;organelle lumen,enzyme regulator activity;protein binding,"Pf00018, Pf00169, Pf00620, Pf14604",64333,,ARHGAP9,12,,,Neutrophil degranulation; Rho GTPase cycle,6,High,1
Q96P47,"Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 OS=Homo sapiens OX=9606 GN=AGAP3 PE=1 SV=2",0.022,2.722,2,1,1,1,875,95,7.97,138,,1,,regulation of biological process;response to stimulus,cytoplasm;membrane,catalytic activity;enzyme regulator activity;metal ion binding;nucleotide binding;protein binding,"Pf00023, Pf00071, Pf00169, Pf01412, Pf08477, Pf12796, Pf13637, Pf13857",116988,ENSG00000133612.18,AGAP3,7,Endocytosis,,,1,High,1
P42263,Glutamate receptor 3 OS=Homo sapiens OX=9606 GN=GRIA3 PE=1 SV=2,0.022,2.718,1,1,1,1,894,101.1,8.54,314,,1,,regulation of biological process;response to stimulus;transport,membrane,receptor activity;signal transducer activity;transporter activity,"Pf00060, Pf00497, Pf01094, Pf10613",2892,ENSG00000125675.17,GRIA3,X,Transcriptional misregulation in cancer; Glutamatergic synapse; Long-term depression; Amphetamine addiction; Retrograde endocannabinoid signaling; Neuroactive ligand-receptor interaction; Nicotine addiction; Circadian entrainment; cAMP signaling pathway; Dopaminergic synapse,Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Common Pathways Underlying Drug Addiction,"Activation of AMPA receptors; Unblocking of NMDA receptor, glutamate binding and activation; Trafficking of GluR2-containing AMPA receptors; Synaptic adhesion-like molecules",23,High,1
Q96IF1,LIM domain-containing protein ajuba OS=Homo sapiens OX=9606 GN=AJUBA PE=1 SV=1,0.022,2.715,4,1,2,1,538,56.9,7.14,521,,1,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;Golgi;membrane;nucleus,metal ion binding;protein binding,Pf00412,84962,ENSG00000129474.15,AJUBA,14,Hippo signaling pathway -multiple species; Hippo signaling pathway,Interleukin-1 Induced Activation of NF-kappa-B,Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Regulation of PLK1 Activity at G2/M Transition,16,High,1
O75052,Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein OS=Homo sapiens OX=9606 GN=NOS1AP PE=1 SV=3,0.022,2.713,2,1,6,1,506,56.1,6.3,804,,1,,regulation of biological process,cytosol;membrane;mitochondrion;nucleus,protein binding,Pf00640,9722,ENSG00000198929.12,NOS1AP,1,Circadian entrainment,Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,,2,High,1
Q53GS7,Nucleoporin GLE1 OS=Homo sapiens OX=9606 GN=GLE1 PE=1 SV=2,0.022,2.711,2,1,1,1,698,79.8,7.43,369,,1,,regulation of biological process;transport,cytoplasm;cytosol;membrane;nucleus,protein binding,"Pf07817, Pf13654",2733,ENSG00000119392.14,GLE1,9,,,Transport of Mature mRNA derived from an Intron-Containing Transcript,4,High,1
P20265-2,"Isoform N-OCT 5A of POU domain, class 3, transcription factor 2 OS=Homo sapiens OX=9606 GN=POU3F2",0.022,2.71,14,1,1,1,263,28.7,8.22,,0,,1,cell differentiation;cell division;cellular component movement;metabolic process;regulation of biological process;response to stimulus,nucleus,DNA binding;protein binding,"Pf00046, Pf00157, Pf13560",5454,,POU3F2,6,,Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,,1,High,1
Q6I9Y2,THO complex subunit 7 homolog OS=Homo sapiens OX=9606 GN=THOC7 PE=1 SV=3,0.022,2.699,5,1,3,1,204,23.7,5.67,1236,,1,,metabolic process;transport,cytoplasm;cytosol;nucleus,protein binding;RNA binding,Pf05615,80145,ENSG00000163634.11,THOC7,3,RNA transport,,Cleavage of Growing Transcript in the Termination Region ; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing,10,High,1
O60279,Sushi domain-containing protein 5 OS=Homo sapiens OX=9606 GN=SUSD5 PE=1 SV=3,0.022,2.694,1,1,12,1,629,68,4.91,4679,,1,,regulation of biological process;response to stimulus,membrane,,"Pf00084, Pf00193",26032,ENSG00000173705.8,SUSD5,3,,,,0,High,1
Q5VT06,Centrosome-associated protein 350 OS=Homo sapiens OX=9606 GN=CEP350 PE=1 SV=1,0.022,2.693,0,1,1,1,3117,350.7,6.33,275,,1,,cell organization and biogenesis,cytoplasm;cytoskeleton;membrane;nucleus,protein binding,Pf01302,9857,ENSG00000135837.15,CEP350,1,,,,0,High,1
O15054,Lysine-specific demethylase 6B OS=Homo sapiens OX=9606 GN=KDM6B PE=1 SV=4,0.022,2.693,2,1,16,1,1643,176.5,8.54,8152,,1,,cell differentiation;cell organization and biogenesis;defense response;metabolic process;regulation of biological process;response to stimulus,nucleus,catalytic activity;DNA binding;metal ion binding;protein binding,Pf02373,23135,ENSG00000132510.10,KDM6B,17,,Pathways Affected in Adenoid Cystic Carcinoma,HDMs demethylate histones; Oxidative Stress Induced Senescence,8,High,1
P52756,RNA-binding protein 5 OS=Homo sapiens OX=9606 GN=RBM5 PE=1 SV=2,0.022,2.692,1,1,8,1,815,92.1,6.28,2702,,1,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process,nucleus;spliceosomal complex,DNA binding;metal ion binding;protein binding;RNA binding,"Pf00076, Pf00641, Pf01585, Pf12656, Pf14259",10181,ENSG00000003756.16,RBM5,3,,mRNA Processing,mRNA Splicing - Major Pathway,5,High,1
Q9H7L9,Sin3 histone deacetylase corepressor complex component SDS3 OS=Homo sapiens OX=9606 GN=SUDS3 PE=1 SV=2,0.022,2.69,4,1,2,1,328,38.1,5.66,538,,1,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process,cytosol;nucleus,catalytic activity;protein binding,Pf08598,64426,ENSG00000111707.11,SUDS3,12,,,HDACs deacetylate histones; NoRC negatively regulates rRNA expression; Ub-specific processing proteases,11,High,1
Q9NWR8,"Calcium uniporter regulatory subunit MCUb, mitochondrial OS=Homo sapiens OX=9606 GN=MCUB PE=1 SV=2",0.022,2.689,4,1,1,1,336,39.1,9.16,416,,1,,cellular homeostasis;transport,membrane;mitochondrion,transporter activity,Pf04678,55013,ENSG00000005059.15,CCDC109B; MCUB,4,,,Processing of SMDT1,3,High,1
P45844,ATP-binding cassette sub-family G member 1 OS=Homo sapiens OX=9606 GN=ABCG1 PE=1 SV=3,0.023,2.688,2,1,2,1,678,75.5,7.81,667,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,endoplasmic reticulum;endosome;Golgi;membrane;mitochondrion,catalytic activity;nucleotide binding;protein binding;transporter activity,"Pf00005, Pf01061, Pf01926, Pf03193, Pf12698, Pf13207, Pf13304",9619,ENSG00000160179.18,ABCG1,21,ABC transporters,Nuclear Receptors in Lipid Metabolism and Toxicity,HDL remodeling; ABC transporters in lipid homeostasis,8,High,1
Q6UY01,Leucine-rich repeat-containing protein 31 OS=Homo sapiens OX=9606 GN=LRRC31 PE=2 SV=1,0.023,2.685,2,1,9,1,552,61.5,6.02,3448,,1,,,,protein binding,Pf13855,79782,ENSG00000114248.9,LRRC31,3,,,,0,High,1
Q9UJA3,DNA helicase MCM8 OS=Homo sapiens OX=9606 GN=MCM8 PE=1 SV=2,0.023,2.685,2,1,8,1,840,93.6,7.75,2785,,1,,metabolic process;response to stimulus,nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding,"Pf00493, Pf14551",84515,ENSG00000125885.13,MCM8,20,,Cell Cycle,M/G1 Transition; CDT1 association with the CDC6:ORC:origin complex; Unwinding of DNA; Regulation of DNA replication; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation; Orc1 removal from chromatin; Removal of licensing factors from origins,25,High,1
Q86X02,Cerebellar degeneration-related protein 2-like OS=Homo sapiens OX=9606 GN=CDR2L PE=1 SV=2,0.023,2.68,3,1,1,1,465,53,6.01,375,,1,,,,protein binding,,30850,ENSG00000109089.7,CDR2L,17,,,,0,High,1
Q15596,Nuclear receptor coactivator 2 OS=Homo sapiens OX=9606 GN=NCOA2 PE=1 SV=2,0.023,2.677,1,1,1,1,1464,159.1,6.64,424,,1,,metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;nucleus,DNA binding;metal ion binding;protein binding;receptor activity;signal transducer activity,"Pf00989, Pf07469, Pf08815, Pf08832, Pf13426, Pf14598",10499,ENSG00000140396.12,NCOA2,8,Thyroid hormone signaling pathway,Androgen receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Constitutive Androstane Receptor Pathway,"Transcriptional regulation of white adipocyte differentiation; Endogenous sterols; Activation of gene expression by SREBF (SREBP); RORA activates gene expression; HATs acetylate histones; PPARA activates gene expression; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; YAP1- and WWTR1 (TAZ)-stimulated gene expression; Transcriptional activation of mitochondrial biogenesis; Synthesis of bile acids and bile salts via 27-hydroxycholesterol; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Recycling of bile acids and salts; BMAL1:CLOCK,NPAS2 activates circadian gene expression; RUNX3 regulates YAP1-mediated transcription",43,High,1
Q8NFZ8,Cell adhesion molecule 4 OS=Homo sapiens OX=9606 GN=CADM4 PE=1 SV=1,0.023,2.668,2,1,4,1,388,42.8,6.3,1417,,1,,,membrane,protein binding;receptor activity,"Pf00047, Pf02124, Pf07679, Pf07686, Pf08205, Pf13895, Pf13927",199731,ENSG00000105767.2,CADM4,19,,,,0,High,1
Q9P0T7,Transmembrane protein 9 OS=Homo sapiens OX=9606 GN=TMEM9 PE=1 SV=1,0.023,2.662,7,1,1,1,183,20.6,6.65,280,,1,,transport,endosome;membrane;vacuole,,Pf05434,252839,ENSG00000116857.16,TMEM9,1,,,,0,High,1
Q9BW60,Elongation of very long chain fatty acids protein 1 OS=Homo sapiens OX=9606 GN=ELOVL1 PE=1 SV=1,0.023,2.661,4,1,3,1,279,32.6,9.6,1020,,1,,metabolic process,endoplasmic reticulum;membrane,catalytic activity;protein binding,Pf01151,64834,ENSG00000066322.14,ELOVL1,1,Fatty acid elongation,,Synthesis of very long-chain fatty acyl-CoAs; Linoleic acid (LA) metabolism; alpha-linolenic acid (ALA) metabolism,9,High,1
P31415,Calsequestrin-1 OS=Homo sapiens OX=9606 GN=CASQ1 PE=1 SV=3,0.023,2.655,6,1,1,1,396,45.1,4.16,280,,1,,cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;endoplasmic reticulum;Golgi;membrane;mitochondrion;organelle lumen,metal ion binding;protein binding,"Pf01216, Pf13848",844,ENSG00000143318.12,CASQ1,1,,Calcium Regulation in the Cardiac Cell,Ion homeostasis; Stimuli-sensing channels,7,High,1
Q9UI42,Carboxypeptidase A4 OS=Homo sapiens OX=9606 GN=CPA4 PE=1 SV=2,0.023,2.653,2,1,1,1,421,47.3,6.7,316,,1,,cell organization and biogenesis;metabolic process,extracellular,catalytic activity;metal ion binding;protein binding,"Pf00246, Pf02244",51200,ENSG00000128510.10,CPA4,7,,,,0,High,1
Q15742,NGFI-A-binding protein 2 OS=Homo sapiens OX=9606 GN=NAB2 PE=1 SV=1,0.023,2.65,2,1,1,1,525,56.6,6.96,429,,1,,cell differentiation;cell proliferation;metabolic process;regulation of biological process,nucleus,protein binding,"Pf04904, Pf04905",4665,ENSG00000166886.12,NAB2,12,,,,0,High,1
A8MZF0,Proline-rich protein 33 OS=Homo sapiens OX=9606 GN=PRR33 PE=4 SV=2,0.023,2.646,2,1,2,1,331,35.2,8.35,,1.79,,1,,,,Pf15485,102724536,,C11orf89; PRR33; LOC102724536,11,,,,0,High,1
Q14790,Caspase-8 OS=Homo sapiens OX=9606 GN=CASP8 PE=1 SV=1,0.023,2.645,3,1,1,1,479,55.4,5.1,406,,1,,cell death;cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane;mitochondrion;nucleus,catalytic activity;protein binding;transporter activity,"Pf00656, Pf01335",841,ENSG00000064012.21,CASP8,2,Alzheimer's disease; Pathways in cancer; TNF signaling pathway; Legionellosis; Non-alcoholic fatty liver disease (NAFLD); Toxoplasmosis; Hepatitis B; Viral carcinogenesis; Viral myocarditis; Apoptosis - multiple species; Toll-like receptor signaling pathway; Huntington's disease; p53 signaling pathway; NOD-like receptor signaling pathway; Platinum drug resistance; Apoptosis; Chagas disease (American trypanosomiasis); RIG-I-like receptor signaling pathway; Tuberculosis; Herpes simplex infection,Nucleotide-binding Oligomerization Domain (NOD) pathway; Regulation of toll-like receptor signaling pathway; miRNA Regulation of DNA Damage Response; Integrated Breast Cancer Pathway; TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway; Alzheimers Disease; TNF alpha Signaling Pathway; AGE/RAGE pathway; Allograft Rejection; Parkin-Ubiquitin Proteasomal System pathway; Nanomaterial induced apoptosis; Nanoparticle triggered regulated necrosis; Apoptosis; Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation; MAPK Signaling Pathway; Apoptosis Modulation by HSP70; RIG-I-like Receptor Signaling; DNA Damage Response; Toll-like receptor signaling pathway,"CLEC7A/inflammasome pathway; TLR3-mediated TICAM1-dependent programmed cell death; FasL/ CD95L signaling; TRAIL  signaling; NOD1/2 Signaling Pathway; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; TNFR1-induced proapoptotic signaling; Caspase-mediated cleavage of cytoskeletal proteins; Activated TLR4 signalling; Dimerization of procaspase-8; Activation, myristolyation of BID and translocation to mitochondria; TRIF-mediated programmed cell death; Regulation of TNFR1 signaling; Regulation by c-FLIP; CASP8 activity is inhibited",78,High,1
Q96IY1,Kinetochore-associated protein NSL1 homolog OS=Homo sapiens OX=9606 GN=NSL1 PE=1 SV=3,0.023,2.639,2,1,3,1,281,32.1,6.79,1089,,1,,cell division;cell organization and biogenesis,chromosome;cytosol;nucleus,protein binding,Pf08641,25936,ENSG00000117697.14,NSL1,1,,,Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins,16,High,1
Q02040,A-kinase anchor protein 17A OS=Homo sapiens OX=9606 GN=AKAP17A PE=1 SV=2,0.023,2.639,1,1,29,1,695,80.7,9.73,11647,,1,,metabolic process;regulation of biological process;response to stimulus,cytosol;nucleus;spliceosomal complex,protein binding;RNA binding,Pf00076,8227,ENSG00000197976.11,AKAP17A,X|Y; X,,,,0,High,1
Q9HAF1,Chromatin modification-related protein MEAF6 OS=Homo sapiens OX=9606 GN=MEAF6 PE=1 SV=1,0.023,2.638,12,1,2,1,191,21.6,9.32,445,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,chromosome;cytosol;nucleus,protein binding,"Pf09340, Pf14782",64769,ENSG00000163875.15,MEAF6,1,,,HATs acetylate histones; Regulation of TP53 Activity through Acetylation,9,High,1
A1A5D9,BICD family-like cargo adapter 2 OS=Homo sapiens OX=9606 GN=BICDL2 PE=1 SV=2,0.024,2.63,2,1,4,1,508,56.8,5.02,1363,,1,,,,protein binding,,146439,ENSG00000162069.14,CCDC64B; BICDL2,16,,,,0,High,1
Q86V35,Calcium-binding protein 7 OS=Homo sapiens OX=9606 GN=CABP7 PE=1 SV=1,0.024,2.63,3,1,2,1,215,24.4,4.67,771,,1,,,cytoplasm;Golgi;membrane,metal ion binding,"Pf00036, Pf13202, Pf13405, Pf13499, Pf13833",164633,ENSG00000100314.3,CABP7,22,,,,0,High,1
O60765,Zinc finger protein 354A OS=Homo sapiens OX=9606 GN=ZNF354A PE=1 SV=2,0.024,2.626,1,1,6,1,605,69.2,9.57,2279,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytosol;nucleus,DNA binding;metal ion binding,"Pf00096, Pf01352, Pf13465",6940,ENSG00000169131.11,ZNF354A,5,,,Generic Transcription Pathway,3,High,1
Q9NRG0,Chromatin accessibility complex protein 1 OS=Homo sapiens OX=9606 GN=CHRAC1 PE=1 SV=1,0.024,2.621,6,1,5,1,131,14.7,5.1,1632,,1,,cell organization and biogenesis;metabolic process,nucleus,catalytic activity;DNA binding;protein binding,Pf00808,54108,ENSG00000104472.9,CHRAC1,8,,,,0,High,1
O00115,Deoxyribonuclease-2-alpha OS=Homo sapiens OX=9606 GN=DNASE2 PE=1 SV=2,0.024,2.616,2,1,1,1,360,39.6,8.05,281,,1,,cell death;cell differentiation;development;metabolic process,vacuole,catalytic activity;DNA binding,Pf03265,1777,ENSG00000105612.8,DNASE2,19,Lysosome,,Lysosome Vesicle Biogenesis,6,High,1
Q92752,Tenascin-R OS=Homo sapiens OX=9606 GN=TNR PE=1 SV=3,0.024,2.614,1,1,37,1,1358,149.5,4.82,13430,,1,,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cell surface;extracellular;membrane,protein binding,"Pf00041, Pf00147, Pf07974",7143,ENSG00000116147.16,TNR,1,ECM-receptor interaction; MicroRNAs in cancer; PI3K-Akt signaling pathway; Focal adhesion,Focal Adhesion; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,ECM proteoglycans,8,High,1
Q9UL68,Myelin transcription factor 1-like protein OS=Homo sapiens OX=9606 GN=MYT1L PE=2 SV=3,0.024,2.612,2,1,1,1,1186,133,4.97,474,,1,,cell differentiation;development;metabolic process;regulation of biological process,chromosome;nucleus,DNA binding;metal ion binding,"Pf01530, Pf03961, Pf06785, Pf07028, Pf08474, Pf08614, Pf12329",23040,ENSG00000186487.17,MYT1L,2,,,,0,High,1
P06731,Carcinoembryonic antigen-related cell adhesion molecule 5 OS=Homo sapiens OX=9606 GN=CEACAM5 PE=1 SV=3,0.025,2.611,1,1,6,1,702,76.7,5.92,2317,,1,,cellular component movement;metabolic process;regulation of biological process,extracellular;membrane,protein binding,"Pf00047, Pf07679, Pf07686, Pf13895, Pf13927",1048,,CEACAM5,19,,,Post-translational modification: synthesis of GPI-anchored proteins; Cell surface interactions at the vascular wall,5,High,1
Q5U3C3,Transmembrane protein 164 OS=Homo sapiens OX=9606 GN=TMEM164 PE=2 SV=1,0.025,2.597,6,1,4,1,297,33.5,8.16,804,,1,,,membrane,,Pf14808,84187,ENSG00000157600.11,TMEM164,X,,,,0,High,1
Q9UBU8,Mortality factor 4-like protein 1 OS=Homo sapiens OX=9606 GN=MORF4L1 PE=1 SV=2,0.025,2.588,6,1,2,1,362,41.4,9.28,386,,1,,cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus,nucleus,protein binding,"Pf05712, Pf11717",10933,ENSG00000185787.14,MORF4L1,15,,Pathways Affected in Adenoid Cystic Carcinoma,HATs acetylate histones,4,High,1
Q9H8G1,Zinc finger protein 430 OS=Homo sapiens OX=9606 GN=ZNF430 PE=1 SV=3,0.025,2.586,1,1,1,1,570,66.3,8.65,589,,1,,metabolic process;regulation of biological process,nucleus,DNA binding;metal ion binding,"Pf00096, Pf01352, Pf13465",80264,ENSG00000118620.12,ZNF430,19,,,Generic Transcription Pathway,3,High,1
Q9P0U4,CXXC-type zinc finger protein 1 OS=Homo sapiens OX=9606 GN=CXXC1 PE=1 SV=2,0.025,2.584,2,1,2,1,656,75.7,8.24,710,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,cytosol;nucleus,catalytic activity;DNA binding;metal ion binding;protein binding,"Pf00628, Pf02008, Pf12269",30827,ENSG00000154832.14,CXXC1,18,,,XBP1(S) activates chaperone genes,4,High,1
Q8NI08,Nuclear receptor coactivator 7 OS=Homo sapiens OX=9606 GN=NCOA7 PE=1 SV=2,0.025,2.581,3,1,1,1,942,106.1,5.59,378,,1,,metabolic process;regulation of biological process,nucleus,protein binding,"Pf01476, Pf07534",135112,ENSG00000111912.19,NCOA7,6,,Aryl Hydrocarbon Receptor,,1,High,1
O95393,Bone morphogenetic protein 10 OS=Homo sapiens OX=9606 GN=BMP10 PE=1 SV=1,0.025,2.58,2,1,7,1,424,48,5,2272,,1,,cell organization and biogenesis;cell proliferation;development;metabolic process;regulation of biological process;response to stimulus,cell surface;cytoplasm;extracellular,protein binding,"Pf00019, Pf00688",27302,ENSG00000163217.1,BMP10,2,,Heart Development; VEGFA-VEGFR2 Signaling Pathway,Signaling by BMP; Molecules associated with elastic fibres,8,High,1
O00257,E3 SUMO-protein ligase CBX4 OS=Homo sapiens OX=9606 GN=CBX4 PE=1 SV=3,0.026,2.578,1,1,5,1,560,61.3,9.36,1615,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,nucleus,catalytic activity;DNA binding;protein binding;RNA binding,Pf00385,8535,ENSG00000141582.14,CBX4,17,,,RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; SUMOylation of chromatin organization proteins; Regulation of PTEN gene transcription; SUMOylation of DNA damage response and repair proteins; Oxidative Stress Induced Senescence; SUMOylation of RNA binding proteins,21,High,1
O60346,PH domain leucine-rich repeat-containing protein phosphatase 1 OS=Homo sapiens OX=9606 GN=PHLPP1 PE=1 SV=3,0.026,2.577,1,1,12,1,1717,184.6,6.28,5608,,1,,cell death;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;nucleus,catalytic activity;metal ion binding;protein binding,"Pf00169, Pf00481, Pf12799, Pf13855",23239,ENSG00000081913.13,PHLPP1,18,PI3K-Akt signaling pathway,Focal Adhesion-PI3K-Akt-mTOR-signaling pathway,Negative regulation of the PI3K/AKT network,6,High,1
P78314,SH3 domain-binding protein 2 OS=Homo sapiens OX=9606 GN=SH3BP2 PE=1 SV=2,0.026,2.571,1,1,2,1,561,62.2,7.78,791,,1,,regulation of biological process;response to stimulus,,protein binding,"Pf00017, Pf00169, Pf15413",6452,ENSG00000087266.15,SH3BP2,4,Natural killer cell mediated cytotoxicity,B Cell Receptor Signaling Pathway,,2,High,1
O95785-3,Isoform 3 of Protein Wiz OS=Homo sapiens OX=9606 GN=WIZ,0.026,2.571,1,1,2,1,965,102.9,9.52,,0,,1,cell organization and biogenesis;regulation of biological process,nucleus,metal ion binding;protein binding,,58525,ENSG00000011451.17,WIZ,19,,,,0,High,1
P02655,Apolipoprotein C-II OS=Homo sapiens OX=9606 GN=APOC2 PE=1 SV=1,0.026,2.57,9,1,2,1,101,11.3,4.72,722,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,endosome;extracellular,enzyme regulator activity;protein binding,Pf05355,344,ENSG00000234906.9,APOC2,19,,Mecp2 and Associated Rett Syndrome; Statin Pathway,Signaling by GPCR; Assembly of active LPL and LIPC lipase complexes; HDL remodeling; Retinoid metabolism and transport; Chylomicron assembly; Chylomicron remodeling,17,High,1
Q9UPE1,SRSF protein kinase 3 OS=Homo sapiens OX=9606 GN=SRPK3 PE=1 SV=2,0.026,2.569,3,1,2,1,567,62,7.25,,1.63,,1,cell differentiation;cell organization and biogenesis;development;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf07714",26576,ENSG00000184343.10,SRPK3,X,,,,0,High,1
P42694,Probable helicase with zinc finger domain OS=Homo sapiens OX=9606 GN=HELZ PE=1 SV=2,0.026,2.569,0,1,1,1,1942,218.8,7.42,399,,1,,,membrane;nucleus,catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding;RNA binding,"Pf00580, Pf00642, Pf02562, Pf04851, Pf07728, Pf13086, Pf13087, Pf13245, Pf13604",9931,ENSG00000198265.11,HELZ,17,,,,0,High,1
Q6NSJ0,Myogenesis-regulating glycosidase OS=Homo sapiens OX=9606 GN=MYORG PE=1 SV=2,0.026,2.568,1,1,3,1,714,81,8.4,1007,,1,,metabolic process;regulation of biological process,membrane,catalytic activity,Pf01055,57462,ENSG00000164976.8,KIAA1161; MYORG,9,,Ectoderm Differentiation,,1,High,1
Q9P0Z9,Peroxisomal sarcosine oxidase OS=Homo sapiens OX=9606 GN=PIPOX PE=1 SV=2,0.026,2.561,2,1,4,1,390,44,8.41,1539,,1,,metabolic process,organelle lumen,catalytic activity;protein binding,"Pf00890, Pf01266, Pf13450",51268,ENSG00000179761.11,PIPOX,17,"Metabolic pathways; Lysine degradation; Glycine, serine and threonine metabolism; Peroxisome",,Lysine catabolism,8,High,1
Q6ZRI8,Rho GTPase-activating protein 36 OS=Homo sapiens OX=9606 GN=ARHGAP36 PE=2 SV=1,0.026,2.555,1,1,1,1,547,61.6,9.42,382,,1,,regulation of biological process;response to stimulus,cytosol,enzyme regulator activity,Pf00620,158763,ENSG00000147256.11,ARHGAP36,X,,,Rho GTPase cycle,3,High,1
Q05513,Protein kinase C zeta type OS=Homo sapiens OX=9606 GN=PRKCZ PE=1 SV=4,0.026,2.544,2,1,2,1,592,67.6,5.77,807,,1,,cell growth;cell organization and biogenesis;cellular component movement;defense response;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytosol;endosome;membrane;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf00130, Pf00433, Pf00564, Pf07714, Pf14531",5590,ENSG00000067606.16,PRKCZ,1,Rap1 signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Insulin signaling pathway; Insulin resistance; Endocytosis; Sphingolipid signaling pathway; Type II diabetes mellitus; Hippo signaling pathway; Platelet activation; Tight junction; Chemokine signaling pathway,Type II diabetes mellitus; IL-1 signaling pathway; miRs in Muscle Cell Differentiation; Signaling Pathways in Glioblastoma; TNF alpha Signaling Pathway; AGE/RAGE pathway; Allograft Rejection; Myometrial Relaxation and Contraction Pathways; G Protein Signaling Pathways; Interleukin-1 Induced Activation of NF-kappa-B; MAPK Signaling Pathway; VEGFA-VEGFR2 Signaling Pathway; Chemokine signaling pathway; Wnt Signaling Pathway and Pluripotency; Wnt Signaling Pathway; EGF/EGFR Signaling Pathway; Insulin Signaling; Calcium Regulation in the Cardiac Cell,VEGFR2 mediated cell proliferation; GPVI-mediated activation cascade; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition),40,High,1
P38432,Coilin OS=Homo sapiens OX=9606 GN=COIL PE=1 SV=1,0.026,2.54,2,1,2,1,576,62.6,9.07,604,,1,,,membrane;nucleus,protein binding,,8161,ENSG00000121058.4,COIL,17,,,,0,High,1
Q9NYV4,Cyclin-dependent kinase 12 OS=Homo sapiens OX=9606 GN=CDK12 PE=1 SV=2,0.026,2.539,1,1,3,1,1490,164.1,9.44,726,,1,,metabolic process;regulation of biological process,chromosome;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding,"Pf00069, Pf07714",51755,ENSG00000167258.13,CDK12,17,,,TP53 Regulates Transcription of DNA Repair Genes,5,High,1
Q9NV58,E3 ubiquitin-protein ligase RNF19A OS=Homo sapiens OX=9606 GN=RNF19A PE=1 SV=3,0.026,2.538,1,1,3,1,838,90.6,7.01,1102,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytoskeleton;cytosol;membrane,catalytic activity;metal ion binding;protein binding,"Pf01485, Pf13639",25897,ENSG00000034677.12,RNF19A,8,,Parkin-Ubiquitin Proteasomal System pathway,Antigen processing: Ubiquitination & Proteasome degradation,5,High,1
Q6NUJ5,PWWP domain-containing protein 2B OS=Homo sapiens OX=9606 GN=PWWP2B PE=1 SV=3,0.026,2.535,2,1,2,1,590,63.9,8.21,743,,1,,,,protein binding,Pf00855,170394,ENSG00000171813.13,PWWP2B,10,,,,0,High,1
O75607,Nucleoplasmin-3 OS=Homo sapiens OX=9606 GN=NPM3 PE=1 SV=3,0.026,2.534,9,1,2,1,178,19.3,4.63,372,,1,,metabolic process,cytoskeleton;cytosol;nucleus,protein binding;RNA binding,"Pf02087, Pf03066",10360,ENSG00000107833.10,NPM3,10,,,,0,High,1
Q66K66,Transmembrane protein 198 OS=Homo sapiens OX=9606 GN=TMEM198 PE=1 SV=1,0.026,2.533,3,1,2,1,360,39.4,9.92,814,,1,,development;regulation of biological process;response to stimulus,membrane,,Pf13886,130612,ENSG00000188760.10,TMEM198,2,,,,0,High,1
P57081,tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 OS=Homo sapiens OX=9606 GN=WDR4 PE=1 SV=2,0.026,2.533,2,1,6,1,412,45.5,7.11,2590,,1,,metabolic process,cytosol;nucleus,catalytic activity;protein binding,,10785,ENSG00000160193.11,WDR4,21,,,tRNA modification in the nucleus and cytosol,3,High,1
P49184,Deoxyribonuclease-1-like 1 OS=Homo sapiens OX=9606 GN=DNASE1L1 PE=1 SV=1,0.026,2.533,3,1,1,1,302,33.9,5.74,406,,1,,metabolic process;transport,endoplasmic reticulum;extracellular;nucleus;organelle lumen,catalytic activity;DNA binding,Pf03372,1774,ENSG00000013563.13,DNASE1L1,X,,,Neutrophil degranulation,3,High,1
P49005,DNA polymerase delta subunit 2 OS=Homo sapiens OX=9606 GN=POLD2 PE=1 SV=1,0.026,2.521,3,1,1,1,469,51.3,5.58,231,,1,,cell organization and biogenesis;cellular homeostasis;metabolic process;response to stimulus,nucleus,catalytic activity;DNA binding;protein binding,Pf04042,5425,ENSG00000106628.10,POLD2,7,Purine metabolism; Base excision repair; Homologous recombination; Metabolic pathways; HTLV-I infection; Mismatch repair; DNA replication; Pyrimidine metabolism; Nucleotide excision repair,Homologous recombination; DNA Replication,Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Homologous Recombination (HRR); Gap-filling DNA repair synthesis and ligation in GG-NER; Dual Incision in GG-NER; Polymerase switching; Termination of translesion DNA synthesis; Recognition of DNA damage by PCNA-containing replication complex; Polymerase switching on the C-strand of the telomere; Dual incision in TC-NER; Removal of the Flap Intermediate; PCNA-Dependent Long Patch Base Excision Repair; Removal of the Flap Intermediate from the C-strand,52,High,1
O75794,Cell division cycle protein 123 homolog OS=Homo sapiens OX=9606 GN=CDC123 PE=1 SV=1,0.026,2.518,4,1,2,1,336,39.1,4.81,243,0,1,1,cell division;regulation of biological process,cytoplasm,,Pf07065,8872,ENSG00000151465.13,CDC123,10,,,,0,High,1
Q6ISS4,Leukocyte-associated immunoglobulin-like receptor 2 OS=Homo sapiens OX=9606 GN=LAIR2 PE=1 SV=1,0.026,2.516,5,1,14,1,152,16.3,5.27,5335,,1,,regulation of biological process,extracellular,protein binding,"Pf13895, Pf13927",3904,ENSG00000277335.4; ENSG00000167618.9; ENSG00000274084.4,LAIR2,19; CHR_HSCHR19_4_CTG3_1; CHR_HSCHR19LRC_COX1_CTG3_1,,,Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell,3,High,1
Q9NWK9,Box C/D snoRNA protein 1 OS=Homo sapiens OX=9606 GN=ZNHIT6 PE=1 SV=1,0.027,2.514,1,1,12,1,470,53.9,5.8,4661,,1,,cell organization and biogenesis,,metal ion binding;protein binding,Pf04438,54680,ENSG00000117174.10,ZNHIT6,1,,,,0,High,1
Q06203,Amidophosphoribosyltransferase OS=Homo sapiens OX=9606 GN=PPAT PE=1 SV=1,0.027,2.513,2,1,1,1,517,57.4,6.76,213,,1,,cell organization and biogenesis;metabolic process;response to stimulus;transport,cytosol,catalytic activity;metal ion binding,"Pf00156, Pf00310, Pf13230, Pf13522, Pf13537",5471,ENSG00000128059.8,PPAT,4,"Alanine, aspartate and glutamate metabolism; Metabolic pathways; Purine metabolism",Fluoropyrimidine Activity,Purine ribonucleoside monophosphate biosynthesis,8,High,1
Q09328,"Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A OS=Homo sapiens OX=9606 GN=MGAT5 PE=1 SV=1",0.027,2.513,2,1,2,1,741,84.5,8.12,625,,1,,metabolic process,Golgi;membrane,catalytic activity,"Pf15024, Pf15027",4249,ENSG00000152127.8,MGAT5,2,N-Glycan biosynthesis; Metabolic pathways,,N-Glycan antennae elongation,8,High,1
Q7Z2T5,TRMT1-like protein OS=Homo sapiens OX=9606 GN=TRMT1L PE=1 SV=2,0.027,2.512,1,1,1,1,733,81.7,7.88,307,,1,,metabolic process;response to stimulus,,catalytic activity;metal ion binding;RNA binding,"Pf02005, Pf02475",81627,ENSG00000121486.11,TRMT1L,1,,,,0,High,1
Q8TES7,Fas-binding factor 1 OS=Homo sapiens OX=9606 GN=FBF1 PE=1 SV=2,0.027,2.506,1,1,16,1,1133,125.4,7.08,5303,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytoskeleton;cytosol,catalytic activity;motor activity;protein binding,"Pf00769, Pf01576, Pf02463, Pf04111, Pf10186, Pf12128, Pf13868, Pf14988, Pf15558",85302,ENSG00000188878.19,FBF1,17,,,Anchoring of the basal body to the plasma membrane,3,High,1
Q96LW9,Zinc finger and SCAN domain-containing protein 31 OS=Homo sapiens OX=9606 GN=ZSCAN31 PE=1 SV=2,0.027,2.506,3,1,2,1,406,47.3,6.89,437,,1,,metabolic process;regulation of biological process,nucleus,DNA binding;metal ion binding,"Pf00096, Pf02023, Pf13465",64288,ENSG00000235109.7,ZNF323; ZSCAN31,6,,,,0,High,1
Q9UPM9,B9 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=B9D1 PE=1 SV=1,0.027,2.503,4,1,1,1,204,22.8,7.28,344,,1,,cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane,receptor activity;signal transducer activity,Pf07162,27077,ENSG00000108641.14,B9D1,17,,,Anchoring of the basal body to the plasma membrane,3,High,1
Q9P2I0,Cleavage and polyadenylation specificity factor subunit 2 OS=Homo sapiens OX=9606 GN=CPSF2 PE=1 SV=2,0.027,2.498,1,1,1,1,782,88.4,5.11,362,,1,,metabolic process;transport,membrane;nucleus,protein binding;RNA binding,"Pf00753, Pf07521, Pf10996, Pf12706, Pf13299",53981,ENSG00000165934.12,CPSF2,14,mRNA surveillance pathway,mRNA Processing,mRNA 3'-end processing; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA Splicing - Major Pathway; Cleavage of Growing Transcript in the Termination Region ; Processing of Intronless Pre-mRNAs,16,High,1
O75691,Small subunit processome component 20 homolog OS=Homo sapiens OX=9606 GN=UTP20 PE=1 SV=3,0.027,2.497,0,1,1,1,2785,318.2,7.39,293,,1,,metabolic process;regulation of biological process,cytoplasm;membrane;nucleus,protein binding;RNA binding,Pf07539,27340,ENSG00000120800.4,UTP20,12,,,Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol,5,High,1
Q92925,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 OS=Homo sapiens OX=9606 GN=SMARCD2 PE=1 SV=3,0.028,2.491,4,1,1,1,531,58.9,9.64,394,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,nucleus,DNA binding;protein binding,Pf02201,6603,ENSG00000108604.15,SMARCD2,17,,,RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines,8,High,1
Q8NHQ8,Ras association domain-containing protein 8 OS=Homo sapiens OX=9606 GN=RASSF8 PE=1 SV=2,0.027,2.49,2,1,1,1,419,48.3,6.49,264,,1,,cell organization and biogenesis;regulation of biological process;response to stimulus,,,Pf00788,11228,ENSG00000123094.15,RASSF8,12,,,,0,High,1
Q6UX46,ALK and LTK ligand 2 OS=Homo sapiens OX=9606 GN=ALKAL2 PE=1 SV=2,0.027,2.489,7,1,1,1,152,16.9,9.69,198,,1,,regulation of biological process,extracellular,enzyme regulator activity;protein binding,Pf15129,285016,ENSG00000189292.15,FAM150B; ALKAL2,2,,,,0,High,1
Q9NUG6,p53 and DNA damage-regulated protein 1 OS=Homo sapiens OX=9606 GN=PDRG1 PE=1 SV=2,0.027,2.489,10,1,1,1,133,15.5,6.06,333,,1,,metabolic process,cytoplasm,protein binding,Pf01920,81572,ENSG00000088356.5,PDRG1,20,,,,0,High,1
O15037,Protein KHNYN OS=Homo sapiens OX=9606 GN=KHNYN PE=1 SV=3,0.028,2.487,1,1,2,1,678,74.5,7.02,552,,1,,,,RNA binding,Pf11977,23351,ENSG00000100441.9,KHNYN,14,,,,0,High,1
Q9Y4D8-5,Isoform 5 of Probable E3 ubiquitin-protein ligase HECTD4 OS=Homo sapiens OX=9606 GN=HECTD4,0.028,2.483,1,1,1,1,1321,145,5.78,,0,,1,metabolic process,cytoplasm,catalytic activity,,283450,,HECTD4,12,,,,0,High,1
Q7LC44,Activity-regulated cytoskeleton-associated protein OS=Homo sapiens OX=9606 GN=ARC PE=1 SV=1,0.028,2.482,2,1,5,1,396,45.3,5.63,2053,,1,,cell organization and biogenesis;cellular component movement;development;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;endosome;membrane,,,23237,ENSG00000198576.3,ARC,8,Amphetamine addiction,BDNF-TrkB Signaling; Serotonin and anxiety-related events; Serotonin and anxiety,,4,High,1
C9JR72,Kelch repeat and BTB domain-containing protein 13 OS=Homo sapiens OX=9606 GN=KBTBD13 PE=1 SV=1,0.028,2.482,2,1,2,1,458,49.5,5.71,,2.06,,1,metabolic process,cytoplasm;cytosol,catalytic activity;protein binding,"Pf00651, Pf01344, Pf07646, Pf13964",390594,ENSG00000234438.3,KBTBD13,15,,,Antigen processing: Ubiquitination & Proteasome degradation; Neddylation,7,High,1
Q9HA72,Calcium homeostasis modulator protein 2 OS=Homo sapiens OX=9606 GN=CALHM2 PE=2 SV=1,0.029,2.482,3,1,1,1,323,36.2,7.69,386,,1,,transport,membrane,transporter activity,Pf14798,51063,ENSG00000138172.10,CALHM2,10,,,,0,High,1
Q86Y37,CDK2-associated and cullin domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CACUL1 PE=1 SV=1,0.029,2.481,6,1,2,1,369,41,5.19,596,,1,,metabolic process;regulation of biological process,,catalytic activity;protein binding,Pf00888,143384,ENSG00000151893.14,CACUL1,10,,,,0,High,1
Q7Z6J4,"FYVE, RhoGEF and PH domain-containing protein 2 OS=Homo sapiens OX=9606 GN=FGD2 PE=1 SV=1",0.029,2.481,1,1,16,1,655,74.8,6.93,5654,,1,,cell organization and biogenesis;regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;endosome;Golgi;membrane;nucleus,metal ion binding;protein binding,"Pf00130, Pf00169, Pf00621, Pf01363, Pf02318",221472,ENSG00000146192.14,FGD2,6,,,G alpha (12/13) signalling events; NRAGE signals death through JNK; Signalling by NGF; Rho GTPase cycle,11,High,1
Q9UHA7,Interleukin-36 alpha OS=Homo sapiens OX=9606 GN=IL36A PE=1 SV=1,0.029,2.477,4,1,1,1,158,17.7,6.3,337,,1,,defense response;regulation of biological process;response to stimulus,extracellular,protein binding,Pf00340,27179,ENSG00000136694.8,IL36A,2,,,Interleukin-36 pathway,5,High,1
Q12830,Nucleosome-remodeling factor subunit BPTF OS=Homo sapiens OX=9606 GN=BPTF PE=1 SV=3,0.029,2.476,0,1,2,1,3046,338.1,6.54,669,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,catalytic activity;DNA binding;metal ion binding;protein binding,"Pf00439, Pf00628, Pf02791, Pf15612",2186,ENSG00000171634.16,BPTF,17,,Endoderm Differentiation,,1,High,1
P49760,Dual specificity protein kinase CLK2 OS=Homo sapiens OX=9606 GN=CLK2 PE=1 SV=1,0.029,2.475,3,1,2,1,499,60.1,9.66,636,,1,,metabolic process;regulation of biological process;response to stimulus,nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00069, Pf07714",1196,ENSG00000261893.5; ENSG00000176444.18,CLK2,1; CHR_HSCHR1_2_CTG31,,mRNA Processing,,1,High,1
Q7Z5R6,Amyloid beta A4 precursor protein-binding family B member 1-interacting protein OS=Homo sapiens OX=9606 GN=APBB1IP PE=1 SV=1,0.029,2.475,1,1,3,1,666,73.1,5.59,882,,1,,regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol;membrane,protein binding,"Pf00169, Pf00788",54518,ENSG00000077420.15,APBB1IP,10,Rap1 signaling pathway; Platelet activation,TYROBP Causal Network,p130Cas linkage to MAPK signaling for integrins; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling by BRAF and RAF fusions; MAP2K and MAPK activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Signaling by RAS mutants; Signaling by high-kinase activity BRAF mutants; Interleukin-20 family signaling; Signaling by moderate kinase activity BRAF mutants,27,High,1
B2RUZ4,Small integral membrane protein 1 OS=Homo sapiens OX=9606 GN=SMIM1 PE=1 SV=1,0.029,2.475,15,1,4,1,78,8.7,9.03,1103,,1,,,membrane,,,388588,ENSG00000235169.7,SMIM1,1,,,,0,High,1
Q7Z333,Probable helicase senataxin OS=Homo sapiens OX=9606 GN=SETX PE=1 SV=4,0.029,2.474,0,1,1,1,2677,302.7,7.17,326,,1,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding,"Pf00580, Pf13086, Pf13087, Pf13245, Pf13401, Pf13604",23064,ENSG00000107290.13,SETX,9,,Interactome of polycomb repressive complex 2 (PRC2),,1,High,1
P16220,Cyclic AMP-responsive element-binding protein 1 OS=Homo sapiens OX=9606 GN=CREB1 PE=1 SV=2,0.029,2.473,4,1,2,1,341,36.7,5.57,398,,1,,cell differentiation;cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,chromosome;mitochondrion;nucleus;organelle lumen,DNA binding;protein binding,"Pf00170, Pf02173",1385,ENSG00000118260.14,CREB1,2,Hepatitis B; HTLV-I infection; Estrogen signaling pathway; Dopaminergic synapse; Adrenergic signaling in cardiomyocytes; Circadian rhythm; Circadian entrainment; Aldosterone synthesis and secretion; Antigen processing and presentation; cGMP-PKG signaling pathway; Thyroid hormone synthesis; Cholinergic synapse; Osteoclast differentiation; Tuberculosis; cAMP signaling pathway; Viral carcinogenesis; Prostate cancer; Vasopressin-regulated water reabsorption; Renin secretion; AMPK signaling pathway; PI3K-Akt signaling pathway; Insulin resistance; Alcoholism; Cocaine addiction; Melanogenesis; Glucagon signaling pathway; Insulin secretion; Huntington's disease; Amphetamine addiction; TNF signaling pathway; Longevity regulating pathway,Androgen receptor signaling pathway; miRNA Regulation of DNA Damage Response; Energy Metabolism; miRNAs involved in DNA damage response; Folate-Alcohol and Cancer Pathway; Sterol Regulatory Element-Binding Proteins (SREBP) signalling; Integrated Breast Cancer Pathway; Human Thyroid Stimulating Hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle Stimulating Hormone (FSH) signaling pathway; B Cell Receptor Signaling Pathway; Interleukin-11 Signaling Pathway; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Oncostatin M Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; ATM Signaling Pathway; Common Pathways Underlying Drug Addiction; Myometrial Relaxation and Contraction Pathways; Mecp2 and Associated Rett Syndrome; Transcription factor regulation in adipogenesis; BDNF-TrkB Signaling; ERK Pathway in Huntington's Disease; VEGFA-VEGFR2 Signaling Pathway; Mitochondrial Gene Expression; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; White fat cell differentiation; p38 MAPK Signaling Pathway; EGF/EGFR Signaling Pathway; G1 to S cell cycle control; Interferon type I signaling pathways; T-Cell antigen Receptor (TCR)  Signaling Pathway; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways; DNA Damage Response; Estrogen signaling pathway; Serotonin Receptor 4/6/7 and NR3C Signaling,"NCAM signaling for neurite out-growth; Activated TLR4 signalling; Signaling by GPCR; AKT phosphorylates targets in the nucleus; CREB phosphorylation through the activation of Adenylate Cyclase; BMAL1:CLOCK,NPAS2 activates circadian gene expression; CREB phosphorylation through the activation of CaMKII; CREB phosphorylation; CREB phosphorylation through the activation of CaMKK; Constitutive Signaling by AKT1 E17K in Cancer; NOTCH2 intracellular domain regulates transcription; Gastrin-CREB signalling pathway via PKC and MAPK; CaMK IV-mediated phosphorylation of CREB; Transcriptional activation of mitochondrial biogenesis; CREB phosphorylation through the activation of Ras; PKA-mediated phosphorylation of CREB",135,High,1
Q8N5H3,Leucine repeat adapter protein 25 OS=Homo sapiens OX=9606 GN=FAM89B PE=1 SV=2,0.029,2.471,7,1,2,1,189,20.1,5.34,386,,1,,regulation of biological process,cytoplasm,protein binding,Pf14854,23625,ENSG00000176973.7,FAM89B,11,,,,0,High,1
Q4VX76,Synaptotagmin-like protein 3 OS=Homo sapiens OX=9606 GN=SYTL3 PE=2 SV=3,0.029,2.47,1,1,12,1,610,68.5,9.28,3556,,1,,cell organization and biogenesis;regulation of biological process;transport,membrane,metal ion binding;protein binding,"Pf00168, Pf02318",94120,ENSG00000164674.15,SYTL3,6,,Deregulation of Rab and Rab Effector Genes in Bladder Cancer,,1,High,1
Q12986,Transcriptional repressor NF-X1 OS=Homo sapiens OX=9606 GN=NFX1 PE=1 SV=2,0.029,2.468,1,1,2,1,1120,124.3,8.24,739,,1,,defense response;metabolic process;regulation of biological process;response to stimulus,cytosol;membrane;nucleus,catalytic activity;DNA binding;metal ion binding;RNA binding,Pf01424,4799,ENSG00000086102.18,NFX1,9,,Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation,,1,High,1
Q96KQ7,Histone-lysine N-methyltransferase EHMT2 OS=Homo sapiens OX=9606 GN=EHMT2 PE=1 SV=3,0.03,2.465,1,1,14,1,1210,132.3,5.45,3664,,1,,cell communication;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;nucleus,catalytic activity;metal ion binding;protein binding,"Pf00023, Pf00856, Pf05033, Pf12796, Pf13606, Pf13637, Pf13857",10919,ENSG00000227333.8; ENSG00000236759.7; ENSG00000206376.9; ENSG00000204371.11,EHMT2,6; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_QBL_CTG1,Longevity regulating pathway; Lysine degradation,Histone Modifications,ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Transcriptional Regulation by E2F6; PKMTs methylate histone lysines; Regulation of TP53 Activity through Methylation; Senescence-Associated Secretory Phenotype (SASP); RNA Polymerase I Transcription Initiation,23,High,1
Q86XI2,Condensin-2 complex subunit G2 OS=Homo sapiens OX=9606 GN=NCAPG2 PE=1 SV=1,0.03,2.463,1,1,1,1,1143,130.9,6.87,393,,1,,cell division;cell organization and biogenesis;cell proliferation;metabolic process,membrane;nucleus,protein binding,Pf12422,54892,ENSG00000146918.19,NCAPG2,7,,Mesodermal Commitment Pathway,Condensation of Prophase Chromosomes,6,High,1
Q8IU99,Calcium homeostasis modulator protein 1 OS=Homo sapiens OX=9606 GN=CALHM1 PE=1 SV=2,0.03,2.463,2,1,9,1,346,38.2,8.18,3310,,1,,cell organization and biogenesis;regulation of biological process;transport,endoplasmic reticulum;membrane,protein binding;transporter activity,Pf14798,255022,ENSG00000185933.6,CALHM1,10,Taste transduction,,,1,High,1
Q53QV2,Protein LBH OS=Homo sapiens OX=9606 GN=LBH PE=1 SV=1,0.03,2.462,15,1,5,1,105,12.2,4.41,2146,,1,,cell differentiation;development;metabolic process;regulation of biological process,cytoplasm;nucleus,,Pf15317,81606,ENSG00000213626.11,LBH,2,,,,0,High,1
Q02224,Centromere-associated protein E OS=Homo sapiens OX=9606 GN=CENPE PE=1 SV=2,0.03,2.452,0,1,6,1,2701,316.2,5.64,2665,,1,,cell division;cell organization and biogenesis;cellular component movement;development;regulation of biological process;transport,chromosome;cytoplasm;cytoskeleton;cytosol;membrane;nucleus,catalytic activity;motor activity;nucleotide binding;protein binding;transporter activity,"Pf00225, Pf01496, Pf02463, Pf04156, Pf05557, Pf06160, Pf08317, Pf10186, Pf12128, Pf13166",1062,ENSG00000138778.11,CENPE,4,,,COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; MHC class II antigen presentation,27,High,1
A0A087X1C5,Putative cytochrome P450 2D7 OS=Homo sapiens OX=9606 GN=CYP2D7 PE=5 SV=1,0.031,2.447,1,1,9,1,515,57.5,8.4,3579,,1,,metabolic process,cytoplasm;membrane;mitochondrion,catalytic activity;metal ion binding,Pf00067,1564,ENSG00000205702.10,CYP2D7P1; CYP2D7P; CYP2D7,22,,Codeine and Morphine Metabolism,,1,High,1
Q6UX07,Dehydrogenase/reductase SDR family member 13 OS=Homo sapiens OX=9606 GN=DHRS13 PE=2 SV=1,0.031,2.446,2,1,1,1,377,40.8,7.69,320,,1,,metabolic process,extracellular;membrane,catalytic activity,"Pf00106, Pf01370, Pf03435, Pf08659, Pf13460, Pf13561",147015,ENSG00000167536.13,DHRS13,17,,,,0,High,1
Q9UL12,"Sarcosine dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=SARDH PE=1 SV=1",0.031,2.446,1,1,8,1,918,101,7.25,2711,,1,,metabolic process,mitochondrion;organelle lumen,catalytic activity,"Pf01266, Pf01571, Pf08669",1757,ENSG00000123453.17,SARDH,9,"Metabolic pathways; Glycine, serine and threonine metabolism",One carbon metabolism and related pathways,Choline catabolism,6,High,1
Q9Y6R1,Electrogenic sodium bicarbonate cotransporter 1 OS=Homo sapiens OX=9606 GN=SLC4A4 PE=1 SV=1,0.031,2.445,1,1,2,1,1079,121.4,6.8,504,,1,,cellular homeostasis;transport,membrane,protein binding;transporter activity,"Pf00359, Pf00955, Pf03606, Pf07565",8671,ENSG00000080493.15,SLC4A4,4,Bile secretion; Pancreatic secretion; Proximal tubule bicarbonate reclamation,,"Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA); Bicarbonate transporters",11,High,1
Q96JN8,Neuralized-like protein 4 OS=Homo sapiens OX=9606 GN=NEURL4 PE=1 SV=2,0.031,2.444,1,1,2,1,1562,166.8,5.86,354,,1,,,cytoplasm;cytoskeleton,protein binding,Pf07177,84461,ENSG00000215041.9,NEURL4,17,,,,0,High,1
Q14406,Chorionic somatomammotropin hormone-like 1 OS=Homo sapiens OX=9606 GN=CSHL1 PE=2 SV=2,0.031,2.443,5,1,6,1,222,25.4,5.91,2012,,1,,regulation of biological process,extracellular,metal ion binding;protein binding,Pf00103,1444,ENSG00000204414.12,CSHL1,17,,,,0,High,1
Q9NZD4,Alpha-hemoglobin-stabilizing protein OS=Homo sapiens OX=9606 GN=AHSP PE=1 SV=1,0.031,2.443,13,1,1,1,102,11.8,5,235,,1,,cell differentiation;metabolic process;regulation of biological process,cytoplasm,protein binding,Pf09236,51327,ENSG00000169877.9,AHSP,16,,,,0,High,1
O14713,Integrin beta-1-binding protein 1 OS=Homo sapiens OX=9606 GN=ITGB1BP1 PE=1 SV=1,0.031,2.442,4,1,5,1,200,21.8,6.34,1436,,1,,cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,enzyme regulator activity;protein binding;transporter activity,Pf10480,9270,ENSG00000119185.12,ITGB1BP1,2,,,,0,High,1
Q96T21,Selenocysteine insertion sequence-binding protein 2 OS=Homo sapiens OX=9606 GN=SECISBP2 PE=1 SV=2,0.031,2.442,1,1,12,1,854,95.4,8.12,2902,,1,,metabolic process;regulation of biological process,mitochondrion;nucleus,protein binding;RNA binding,Pf01248,79048,ENSG00000187742.14,SECISBP2,9,,,Selenocysteine synthesis,4,High,1
Q12788,Transducin beta-like protein 3 OS=Homo sapiens OX=9606 GN=TBL3 PE=1 SV=2,0.031,2.441,1,1,3,1,808,89,6.9,1400,,1,,metabolic process,nucleus,protein binding;RNA binding,"Pf00400, Pf08625",10607,ENSG00000183751.14,TBL3,16,Ribosome biogenesis in eukaryotes,,Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol,6,High,1
O43895,Xaa-Pro aminopeptidase 2 OS=Homo sapiens OX=9606 GN=XPNPEP2 PE=1 SV=3,0.031,2.441,1,1,2,1,674,75.6,6.04,723,,1,,metabolic process,extracellular;membrane,catalytic activity;metal ion binding,"Pf00557, Pf01321",7512,ENSG00000122121.10,XPNPEP2,X,Protein digestion and absorption,,Post-translational modification: synthesis of GPI-anchored proteins,4,High,1
Q7Z3Z3,Piwi-like protein 3 OS=Homo sapiens OX=9606 GN=PIWIL3 PE=2 SV=2,0.031,2.439,1,1,6,1,882,101,9.51,,0,,1,cell differentiation;development;regulation of biological process,cytoplasm,protein binding;RNA binding,"Pf02170, Pf02171",440822,ENSG00000184571.13,PIWIL3,22,Dorso-ventral axis formation,,,1,High,1
Q9P296,C5a anaphylatoxin chemotactic receptor 2 OS=Homo sapiens OX=9606 GN=C5AR2 PE=1 SV=1,0.031,2.439,3,1,2,1,337,36.1,7.87,509,,1,,cellular homeostasis;defense response;regulation of biological process;response to stimulus,membrane,protein binding;receptor activity;signal transducer activity,Pf00001,27202,ENSG00000134830.5,C5AR2; GPR77,19,,"GPCRs, Other; GPCRs, Class A Rhodopsin-like",Peptide ligand-binding receptors; Regulation of Complement cascade,11,High,1
Q9Y228,TRAF3-interacting JNK-activating modulator OS=Homo sapiens OX=9606 GN=TRAF3IP3 PE=1 SV=2,0.031,2.436,2,1,27,1,551,63.6,8.51,10823,,1,,metabolic process,membrane,protein binding,"Pf04111, Pf04156, Pf12128",80342,ENSG00000009790.14,TRAF3IP3,1,,,,0,High,1
O96018,Amyloid-beta A4 precursor protein-binding family A member 3 OS=Homo sapiens OX=9606 GN=APBA3 PE=1 SV=1,0.031,2.434,3,1,1,1,575,61.4,4.94,282,,1,,cell communication;regulation of biological process;transport,cytoplasm,enzyme regulator activity;protein binding,"Pf00595, Pf00640",9546,ENSG00000011132.11,APBA3,19,,,Neurexins and neuroligins,3,High,1
Q8N9M1,Uncharacterized protein C19orf47 OS=Homo sapiens OX=9606 GN=C19orf47 PE=1 SV=1,0.031,2.434,2,1,3,1,422,44.7,10.11,1402,,1,,,,protein binding,,126526,ENSG00000160392.13,C19orf47,19,,,,0,High,1
O75342,"Arachidonate 12-lipoxygenase, 12R-type OS=Homo sapiens OX=9606 GN=ALOX12B PE=1 SV=1",0.031,2.432,1,1,32,1,701,80.3,7.64,10122,,1,,metabolic process;regulation of biological process,cytoplasm;cytosol,catalytic activity;metal ion binding;protein binding,"Pf00305, Pf01477",242,ENSG00000179477.9,ALOX12B,17,Arachidonic acid metabolism; Metabolic pathways; Serotonergic synapse,,Synthesis of 12-eicosatetraenoic acid derivatives,8,High,1
Q6PCB8,Embigin OS=Homo sapiens OX=9606 GN=EMB PE=1 SV=1,0.031,2.431,3,1,3,1,327,36.9,6.54,977,,1,,transport,membrane,transporter activity,"Pf07679, Pf13927",133418,ENSG00000170571.11,EMB,5,,,Proton-coupled monocarboxylate transport,4,High,1
P55103,Inhibin beta C chain OS=Homo sapiens OX=9606 GN=INHBC PE=2 SV=1,0.031,2.426,2,1,2,1,352,38.2,7.11,603,,1,,regulation of biological process;response to stimulus,extracellular,protein binding,"Pf00019, Pf00688",3626,ENSG00000175189.3,INHBC,12,Signaling pathways regulating pluripotency of stem cells; TGF-beta signaling pathway; Cytokine-cytokine receptor interaction,,Glycoprotein hormones,7,High,1
Q9UBL3,Set1/Ash2 histone methyltransferase complex subunit ASH2 OS=Homo sapiens OX=9606 GN=ASH2L PE=1 SV=1,0.031,2.425,2,1,1,1,628,68.7,5.69,306,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,nucleus,catalytic activity;DNA binding;metal ion binding;protein binding,Pf00622,9070,ENSG00000129691.15,ASH2L,8,,,Deactivation of the beta-catenin transactivating complex; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; PKMTs methylate histone lysines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Formation of the beta-catenin:TCF transactivating complex,16,High,1
Q8IWY8,Zinc finger and SCAN domain-containing protein 29 OS=Homo sapiens OX=9606 GN=ZSCAN29 PE=1 SV=2,0.031,2.425,1,1,18,1,852,96.7,6.99,5659,,1,,metabolic process;regulation of biological process,nucleus,DNA binding;metal ion binding,"Pf00096, Pf02023, Pf09723, Pf09879, Pf10545, Pf13465, Pf13837",146050,ENSG00000140265.12,ZSCAN29,15,,,,0,High,1
Q9NYI0,PH and SEC7 domain-containing protein 3 OS=Homo sapiens OX=9606 GN=PSD3 PE=1 SV=2,0.031,2.424,1,1,1,1,1048,116,5.99,309,,1,,regulation of biological process,membrane,,"Pf00169, Pf01369, Pf15410",23362,ENSG00000156011.16,PSD3,8,Endocytosis,,,1,High,1
P85299,Proline-rich protein 5 OS=Homo sapiens OX=9606 GN=PRR5 PE=1 SV=1,0.031,2.422,2,1,122,1,388,42.7,8.18,49809,,1,,regulation of biological process;response to stimulus,cytosol,,Pf08539,55615,ENSG00000186654.20,PRR5,22,mTOR signaling pathway,Target Of Rapamycin (TOR) Signaling,PIP3 activates AKT signaling; CD28 dependent PI3K/Akt signaling; Regulation of TP53 Degradation; VEGFR2 mediated vascular permeability; Constitutive Signaling by AKT1 E17K in Cancer,25,High,1
Q9Y2D9,Zinc finger protein 652 OS=Homo sapiens OX=9606 GN=ZNF652 PE=1 SV=3,0.031,2.422,1,1,1,1,606,69.7,8.65,447,,1,,metabolic process;regulation of biological process,nucleus,DNA binding;metal ion binding;protein binding,"Pf00096, Pf13465",22834,ENSG00000198740.8,ZNF652,17,,,,0,High,1
Q9UKJ5,Cysteine-rich hydrophobic domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CHIC2 PE=1 SV=1,0.031,2.417,5,1,1,1,165,19.2,6.73,477,,1,,transport,Golgi;membrane,protein binding,Pf10256,26511,ENSG00000109220.10,CHIC2,4,,,,0,High,1
P50222,Homeobox protein MOX-2 OS=Homo sapiens OX=9606 GN=MEOX2 PE=1 SV=2,0.031,2.417,5,1,18,1,304,33.6,8,4672,,1,,cell death;development;metabolic process;regulation of biological process,cytoplasm;nucleus,DNA binding;protein binding,Pf00046,4223,ENSG00000106511.5,MEOX2,7,,,,0,High,1
Q5T9S5,Coiled-coil domain-containing protein 18 OS=Homo sapiens OX=9606 GN=CCDC18 PE=1 SV=1,0.031,2.416,1,1,4,1,1454,168.9,5.66,1066,,1,,cell organization and biogenesis;metabolic process,cytoskeleton,,"Pf02463, Pf04111, Pf05667, Pf06160, Pf06785, Pf07888, Pf09726, Pf12128, Pf12252, Pf13166, Pf13514",343099,ENSG00000122483.17,CCDC18,1,,,,0,High,1
P47989,Xanthine dehydrogenase/oxidase OS=Homo sapiens OX=9606 GN=XDH PE=1 SV=4,0.032,2.414,1,1,4,1,1333,146.3,7.66,1232,,1,,metabolic process;regulation of biological process;transport,cytoplasm;cytosol;endoplasmic reticulum;extracellular,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00941, Pf01315, Pf01799, Pf02738, Pf03450",7498,ENSG00000158125.9,XDH,2,Peroxisome; Metabolic pathways; Caffeine metabolism; Drug metabolism - other enzymes; Purine metabolism,Selenium Micronutrient Network; Effects of Nitric Oxide; Caffeine and Theobromine metabolism; Oxidative Stress,Butyrophilin (BTN) family interactions; Purine catabolism,16,High,1
Q14676,Mediator of DNA damage checkpoint protein 1 OS=Homo sapiens OX=9606 GN=MDC1 PE=1 SV=3,0.032,2.414,0,1,1,1,2089,226.5,5.47,378,,1,,metabolic process;regulation of biological process;response to stimulus,chromosome;nucleus,protein binding,"Pf00498, Pf05109, Pf05539",9656,ENSG00000228575.9; ENSG00000137337.14; ENSG00000225589.9; ENSG00000224587.9; ENSG00000234012.9; ENSG00000237095.9,MDC1,6; CHR_HSCHR6_MHC_MANN_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_APD_CTG1; CHR_HSCHR6_MHC_MCF_CTG1,,ATM Signaling Network in Development and Disease,G2/M DNA damage checkpoint; TP53 Regulates Transcription of DNA Repair Genes; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; Nonhomologous End-Joining (NHEJ); SUMOylation of DNA damage response and repair proteins,23,High,1
Q9UBB5,Methyl-CpG-binding domain protein 2 OS=Homo sapiens OX=9606 GN=MBD2 PE=1 SV=1,0.032,2.413,2,1,13,1,411,43.2,10.04,3383,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;cytosol;nucleus,DNA binding;nucleotide binding;protein binding;RNA binding,"Pf01429, Pf14048",8932,ENSG00000134046.11,MBD2,18,,,NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Opening,7,High,1
Q8TF74,WAS/WASL-interacting protein family member 2 OS=Homo sapiens OX=9606 GN=WIPF2 PE=1 SV=1,0.032,2.412,2,1,3,1,440,46.3,10.93,839,,1,,regulation of biological process;response to stimulus,cytoplasm;cytoskeleton;cytosol,protein binding,Pf02205,147179,ENSG00000171475.13,WIPF2,17,Endocytosis,,Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs,9,High,1
P98088,Mucin-5AC OS=Homo sapiens OX=9606 GN=MUC5AC PE=1 SV=4,0.032,2.41,0,1,1,1,5654,585.2,7.02,363,,1,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;extracellular;membrane;organelle lumen,protein binding;structural molecule activity,"Pf00094, Pf01826, Pf08742, Pf13330",4586,ENSG00000283158.1; ENSG00000215182.8,MUC5AC,11; CHR_HG107_PATCH,,,Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC); Dectin-2 family; Defective GALNT12 causes colorectal cancer 1 (CRCS1); Termination of O-glycan biosynthesis; Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS),15,High,1
Q01780,Exosome component 10 OS=Homo sapiens OX=9606 GN=EXOSC10 PE=1 SV=2,0.032,2.407,1,1,5,1,885,100.8,8.46,1725,,1,,metabolic process;regulation of biological process,cytoplasm;cytosol;membrane;nucleus,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00570, Pf01612, Pf08066",5394,ENSG00000171824.13,EXOSC10,1,RNA degradation,,Major pathway of rRNA processing in the nucleolus and cytosol,5,High,1
Q14703,Membrane-bound transcription factor site-1 protease OS=Homo sapiens OX=9606 GN=MBTPS1 PE=1 SV=1,0.032,2.405,1,1,3,1,1052,117.7,8.75,1057,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;Golgi;membrane;organelle lumen,catalytic activity,"Pf00082, Pf14258",8720,ENSG00000140943.16,MBTPS1,16,Protein processing in endoplasmic reticulum,Sterol Regulatory Element-Binding Proteins (SREBP) signalling,Post-translational protein phosphorylation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Assembly of active LPL and LIPC lipase complexes; Regulation of cholesterol biosynthesis by SREBP (SREBF); CREB3 factors activate genes; ATF6 (ATF6-alpha) activates chaperones,17,High,1
Q5H9F3,BCL-6 corepressor-like protein 1 OS=Homo sapiens OX=9606 GN=BCORL1 PE=1 SV=1,0.032,2.404,0,1,1,1,1711,182.4,7.24,213,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,membrane;nucleus,protein binding,"Pf00023, Pf12796, Pf13606, Pf13637, Pf13857",63035,,BCORL1,X,,Mesodermal Commitment Pathway; Pathways Affected in Adenoid Cystic Carcinoma,,2,High,1
Q9UPR3,Protein SMG5 OS=Homo sapiens OX=9606 GN=SMG5 PE=1 SV=3,0.032,2.402,1,1,2,1,1016,113.9,5.91,443,,1,,metabolic process;regulation of biological process;transport,cytoplasm;cytosol;nucleus,catalytic activity;DNA binding;protein binding;RNA binding,"Pf10373, Pf10374, Pf13638",23381,ENSG00000198952.8,SMG5,1,mRNA surveillance pathway,,Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC),4,High,1
P00797,Renin OS=Homo sapiens OX=9606 GN=REN PE=1 SV=1,0.032,2.402,8,1,2,1,406,45,7.06,161,,1,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;extracellular;membrane,catalytic activity;protein binding,"Pf00026, Pf07966, Pf13650, Pf14541, Pf14543",5972,ENSG00000143839.14,REN,1,Renin-angiotensin system; Renin secretion,ACE Inhibitor Pathway,Metabolism of Angiotensinogen to Angiotensins,6,High,1
Q96Q89,Kinesin-like protein KIF20B OS=Homo sapiens OX=9606 GN=KIF20B PE=1 SV=3,0.032,2.402,1,1,2,1,1820,210.5,5.67,757,,1,,cell division;cell organization and biogenesis;cellular component movement;regulation of biological process,cytoplasm;cytoskeleton;cytosol;nucleus,catalytic activity;motor activity;nucleotide binding;protein binding,"Pf00225, Pf01576, Pf02463, Pf03961, Pf07851, Pf09726",9585,ENSG00000138182.14,KIF20B,10,,Gastric Cancer Network 1,COPI-dependent Golgi-to-ER retrograde traffic; Kinesins,9,High,1
Q6PJP8,DNA cross-link repair 1A protein OS=Homo sapiens OX=9606 GN=DCLRE1A PE=1 SV=3,0.032,2.397,1,1,16,1,1040,116.3,7.97,3913,,1,,cell division;cell organization and biogenesis;metabolic process;response to stimulus,nucleus,catalytic activity;DNA binding,"Pf00753, Pf07522, Pf12706",9937,ENSG00000198924.7,DCLRE1A,10,,,Fanconi Anemia Pathway,2,High,1
Q4G0J3,La-related protein 7 OS=Homo sapiens OX=9606 GN=LARP7 PE=1 SV=1,0.032,2.397,2,1,1,1,582,66.9,9.55,201,,1,,metabolic process,cytosol;nucleus,protein binding;RNA binding,"Pf00076, Pf05383, Pf08777, Pf13893, Pf14259",51574,ENSG00000174720.15,LARP7,4,,,,0,High,1
Q9HCG8,Pre-mRNA-splicing factor CWC22 homolog OS=Homo sapiens OX=9606 GN=CWC22 PE=1 SV=3,0.032,2.397,2,1,3,1,908,105.4,7.03,1198,,1,,metabolic process;regulation of biological process,cytosol;nucleus;spliceosomal complex,protein binding;RNA binding,"Pf02847, Pf02854",57703,ENSG00000163510.13,CWC22,2,,,mRNA Splicing - Major Pathway,4,High,1
P49711,Transcriptional repressor CTCF OS=Homo sapiens OX=9606 GN=CTCF PE=1 SV=1,0.032,2.395,2,1,12,1,727,82.7,6.96,2433,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,chromosome;nucleus,DNA binding;metal ion binding;protein binding,"Pf06750, Pf13465",10664,ENSG00000102974.14,CTCF,16,,Mecp2 and Associated Rett Syndrome; Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways,Activation of anterior HOX genes in hindbrain development during early embryogenesis,5,High,1
Q8N118,Cytochrome P450 4X1 OS=Homo sapiens OX=9606 GN=CYP4X1 PE=2 SV=1,0.032,2.392,2,1,1,1,509,58.8,8.48,390,,1,,metabolic process,endoplasmic reticulum;membrane,catalytic activity;metal ion binding,Pf00067,260293,ENSG00000186377.7,CYP4X1,1,Serotonergic synapse,Oxidation by Cytochrome P450; Metapathway biotransformation,,3,High,1
Q9Y5F9,Protocadherin gamma-B6 OS=Homo sapiens OX=9606 GN=PCDHGB6 PE=2 SV=1,0.032,2.391,2,1,2,1,930,101,5.26,583,,1,,cell communication,membrane,metal ion binding,"Pf00028, Pf08266",56100,ENSG00000253305.2,PCDHGB6,5,,,,0,High,1
Q9BXC9,Bardet-Biedl syndrome 2 protein OS=Homo sapiens OX=9606 GN=BBS2 PE=1 SV=1,0.032,2.39,1,1,1,1,721,79.8,6.15,436,,1,,cell differentiation;cell organization and biogenesis;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;membrane,protein binding,"Pf01839, Pf14781, Pf14782, Pf14783",583,,BBS2,16,,,BBSome-mediated cargo-targeting to cilium,4,High,1
Q96DU7,Inositol-trisphosphate 3-kinase C OS=Homo sapiens OX=9606 GN=ITPKC PE=1 SV=1,0.032,2.389,3,1,2,1,683,75.2,5.14,362,,1,,metabolic process,cytoplasm;cytosol;nucleus,catalytic activity;nucleotide binding;protein binding,Pf03770,80271,ENSG00000086544.2,ITPKC,19,Metabolic pathways; Inositol phosphate metabolism; Calcium signaling pathway; Phosphatidylinositol signaling system,Integrated Breast Cancer Pathway,Synthesis of IP3 and IP4 in the cytosol,8,High,1
Q9UNU6,7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase OS=Homo sapiens OX=9606 GN=CYP8B1 PE=1 SV=2,0.033,2.386,2,1,3,1,501,58,8.66,643,,1,,metabolic process,endoplasmic reticulum;membrane,catalytic activity;metal ion binding,Pf00067,1582,ENSG00000180432.5,CYP8B1,3,Metabolic pathways; Primary bile acid biosynthesis; PPAR signaling pathway,PPAR Alpha Pathway; Farnesoid X Receptor  Pathway; Nuclear Receptors in Lipid Metabolism and Toxicity; PPAR signaling pathway; Oxidation by Cytochrome P450; Metapathway biotransformation,Eicosanoids; Sterols are 12-hydroxylated by CYP8B1; Synthesis of bile acids and bile salts via 27-hydroxycholesterol; Synthesis of bile acids and bile salts via 24-hydroxycholesterol; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Synthesis of Prostaglandins (PG) and Thromboxanes (TX); Nicotinamide salvaging,30,High,1
Q6P1M3,LLGL scribble cell polarity complex component 2 OS=Homo sapiens OX=9606 GN=LLGL2 PE=1 SV=2,0.033,2.383,1,1,2,1,1020,113.4,7.52,428,,1,,cell division;regulation of biological process;transport,cytoplasm;cytosol;membrane,enzyme regulator activity;protein binding,Pf08366,3993,ENSG00000073350.13,LLGL2,17,Hippo signaling pathway; Tight junction,,,2,High,1
Q9UKJ3,G patch domain-containing protein 8 OS=Homo sapiens OX=9606 GN=GPATCH8 PE=1 SV=2,0.032,2.383,2,1,18,1,1502,164.1,8.66,4688,,1,,,,metal ion binding;protein binding;RNA binding,"Pf12171, Pf13868",23131,ENSG00000186566.12,GPATCH8,17,,,,0,High,1
Q4LE39,AT-rich interactive domain-containing protein 4B OS=Homo sapiens OX=9606 GN=ARID4B PE=1 SV=2,0.032,2.381,1,1,1,1,1312,147.7,5.12,407,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;nucleus,catalytic activity;DNA binding;protein binding,"Pf00855, Pf01388, Pf08169, Pf11717",51742,ENSG00000054267.21,ARID4B,1,,Pathways Affected in Adenoid Cystic Carcinoma,HDACs deacetylate histones; NoRC negatively regulates rRNA expression,8,High,1
Q14562,ATP-dependent RNA helicase DHX8 OS=Homo sapiens OX=9606 GN=DHX8 PE=1 SV=1,0.032,2.38,1,1,12,1,1220,139.2,8.32,3811,,1,,metabolic process,cytoplasm;nucleus;spliceosomal complex,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00271, Pf00575, Pf04408, Pf07717",1659,ENSG00000067596.10,DHX8,17,Spliceosome,mRNA Processing,,2,High,1
Q96DA0,Zymogen granule protein 16 homolog B OS=Homo sapiens OX=9606 GN=ZG16B PE=1 SV=3,0.033,2.376,4,1,1,1,208,22.7,7.39,312,,1,,,extracellular,,,124220,ENSG00000283056.1; ENSG00000162078.11,ZG16B,16; CHR_HSCHR16_5_CTG1,,,,0,High,1
P42575,Caspase-2 OS=Homo sapiens OX=9606 GN=CASP2 PE=1 SV=2,0.033,2.371,4,1,2,1,452,50.7,6.81,240,,1,,cell death;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane;mitochondrion;nucleus,catalytic activity;protein binding,"Pf00619, Pf00656",835,ENSG00000106144.19,CASP2,7,Apoptosis,Apoptosis Modulation and Signaling; Parkinsons Disease Pathway; Apoptosis; MAPK Signaling Pathway; Apoptosis Modulation by HSP70,NOD1/2 Signaling Pathway; TP53 Regulates Transcription of Caspase Activators and Caspases; Signalling by NGF; NADE modulates death signalling,22,High,1
Q6ZRS2,Helicase SRCAP OS=Homo sapiens OX=9606 GN=SRCAP PE=1 SV=3,0.033,2.37,0,1,3,1,3230,343.3,5.96,1302,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,Golgi;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding,"Pf00176, Pf00271, Pf07529",10847,ENSG00000080603.16,SRCAP,16,,Pathways Affected in Adenoid Cystic Carcinoma,,1,High,1
Q9HC56,Protocadherin-9 OS=Homo sapiens OX=9606 GN=PCDH9 PE=1 SV=2,0.033,2.368,1,1,37,1,1237,136,5.47,13355,,1,,,membrane,metal ion binding,"Pf00028, Pf08266, Pf08374",5101,ENSG00000184226.14,PCDH9,13,,,,0,High,1
O43379,WD repeat-containing protein 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=4,0.033,2.367,1,1,2,1,1518,165.8,5.91,374,,1,,cell differentiation;cell organization and biogenesis;metabolic process,cytoplasm;cytoskeleton;nucleus;spliceosomal complex,protein binding;RNA binding,Pf00400,284403,ENSG00000075702.16,WDR62,19,,,,0,High,1
Q86XL3,Ankyrin repeat and LEM domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ANKLE2 PE=1 SV=4,0.033,2.367,2,1,2,1,938,104.1,7.09,427,,1,,cell division;cell organization and biogenesis;regulation of biological process,endoplasmic reticulum;membrane,enzyme regulator activity;protein binding,"Pf00023, Pf01693, Pf03020, Pf12796",23141,ENSG00000176915.14,ANKLE2,12,,,Initiation of Nuclear Envelope Reformation,7,High,1
P00749,Urokinase-type plasminogen activator OS=Homo sapiens OX=9606 GN=PLAU PE=1 SV=2,0.033,2.366,2,1,2,1,431,48.5,8.41,514,,1,,cellular component movement;coagulation;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;extracellular;membrane,catalytic activity;protein binding,"Pf00051, Pf00089",5328,,PLAU,10,Proteoglycans in cancer; NF-kappa B signaling pathway; Transcriptional misregulation in cancer; Complement and coagulation cascades; MicroRNAs in cancer,Osteopontin Signaling; Blood Clotting Cascade; Lung fibrosis; VEGFA-VEGFR2 Signaling Pathway; Wnt Signaling Pathway and Pluripotency; Wnt Signaling Pathway; Endochondral Ossification; Complement and Coagulation Cascades; Senescence and Autophagy in Cancer; DNA Damage Response (only ATM dependent),Dissolution of Fibrin Clot; Neutrophil degranulation,20,High,1
Q9UBV7,"Beta-1,4-galactosyltransferase 7 OS=Homo sapiens OX=9606 GN=B4GALT7 PE=1 SV=1",0.033,2.365,2,1,5,1,327,37.4,8.98,1265,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,Golgi;membrane,catalytic activity;metal ion binding;protein binding,"Pf02709, Pf13733",11285,ENSG00000027847.13,B4GALT7,5,Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate; Glycosaminoglycan biosynthesis - heparan sulfate / heparin; Metabolic pathways,,"A tetrasaccharide linker sequence is required for GAG synthesis; Defective B4GALT7 causes EDS, progeroid type",13,High,1
O75635,Serpin B7 OS=Homo sapiens OX=9606 GN=SERPINB7 PE=1 SV=1,0.033,2.365,3,1,1,1,380,42.9,6.8,294,,1,,regulation of biological process,cytoplasm,enzyme regulator activity,Pf00079,8710,ENSG00000166396.12,SERPINB7,18,,,,0,High,1
Q9H1B7,Probable E3 ubiquitin-protein ligase IRF2BPL OS=Homo sapiens OX=9606 GN=IRF2BPL PE=1 SV=1,0.033,2.364,2,1,1,1,796,82.6,8.24,496,,1,,regulation of biological process,nucleus,metal ion binding;protein binding,Pf11261,64207,ENSG00000119669.4,IRF2BPL,14,,,,0,High,1
O15534,Period circadian protein homolog 1 OS=Homo sapiens OX=9606 GN=PER1 PE=1 SV=2,0.033,2.361,1,1,1,1,1290,136.1,6.09,243,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,DNA binding;protein binding,"Pf00989, Pf08447, Pf12114, Pf14598",5187,ENSG00000179094.15,PER1,17,Herpes simplex infection; Circadian entrainment; Circadian rhythm,Melatonin metabolism and effects; Exercise-induced Circadian Regulation,"BMAL1:CLOCK,NPAS2 activates circadian gene expression",7,High,1
Q86U90,"YrdC domain-containing protein, mitochondrial OS=Homo sapiens OX=9606 GN=YRDC PE=1 SV=1",0.033,2.358,5,1,2,1,279,29.3,8.57,541,,1,,metabolic process;regulation of biological process,cytoplasm;membrane;mitochondrion,catalytic activity;RNA binding,Pf01300,79693,ENSG00000196449.3,YRDC,1,,,,0,High,1
Q9Y6X4,Soluble lamin-associated protein of 75 kDa OS=Homo sapiens OX=9606 GN=FAM169A PE=1 SV=2,0.033,2.352,2,1,2,1,670,74.9,4.6,777,,1,,,membrane;nucleus,,,26049,ENSG00000198780.11,FAM169A,5,,,,0,High,1
Q96MF7,E3 SUMO-protein ligase NSE2 OS=Homo sapiens OX=9606 GN=NSMCE2 PE=1 SV=2,0.033,2.35,3,1,11,1,247,27.9,7.74,3015,,1,,cell division;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;nucleus,catalytic activity;metal ion binding;protein binding,"Pf11789, Pf13445",286053,ENSG00000156831.7,NSMCE2,8,,,SUMOylation of DNA damage response and repair proteins,5,High,1
P26367,Paired box protein Pax-6 OS=Homo sapiens OX=9606 GN=PAX6 PE=1 SV=2,0.034,2.348,2,1,1,1,422,46.7,9.36,389,,1,,cell differentiation;cell organization and biogenesis;cellular component movement;development;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;DNA binding;protein binding,"Pf00046, Pf00292, Pf13384, Pf13551",5080,ENSG00000007372.21,PAX6,11,Signaling pathways regulating pluripotency of stem cells; Maturity onset diabetes of the young,Cardiac Progenitor Differentiation; Mesodermal Commitment Pathway; Ectoderm Differentiation,"Activation of anterior HOX genes in hindbrain development during early embryogenesis; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Regulation of gene expression in beta cells; Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)",15,High,1
Q86U44,N6-adenosine-methyltransferase catalytic subunit OS=Homo sapiens OX=9606 GN=METTL3 PE=1 SV=2,0.034,2.346,2,1,1,1,580,64.4,6.42,279,,1,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,catalytic activity;protein binding;RNA binding,Pf05063,56339,ENSG00000165819.11,METTL3,14,,mRNA Processing,Processing of Capped Intron-Containing Pre-mRNA,3,High,1
Q9UBP0,Spastin OS=Homo sapiens OX=9606 GN=SPAST PE=1 SV=1,0.034,2.346,3,1,1,1,616,67.2,9.64,294,,1,,cell differentiation;cell division;cell organization and biogenesis;cellular component movement;development;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum;endosome;membrane;nucleus,catalytic activity;nucleotide binding;protein binding,"Pf00004, Pf00437, Pf01078, Pf04212, Pf05496, Pf06068, Pf07724, Pf07728, Pf13401",6683,ENSG00000021574.11,SPAST,2,,,,0,High,1
Q15058,Kinesin-like protein KIF14 OS=Homo sapiens OX=9606 GN=KIF14 PE=1 SV=1,0.034,2.344,1,1,1,1,1648,186.4,7.91,333,,1,,cell division;cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process,cytoplasm;cytoskeleton;cytosol;membrane;nucleus,catalytic activity;motor activity;nucleotide binding;protein binding,"Pf00225, Pf00498, Pf00769, Pf01576, Pf02463, Pf02841, Pf05262, Pf05622, Pf09726, Pf09731, Pf11068, Pf11740, Pf12128, Pf13514, Pf13868",9928,ENSG00000118193.11,KIF14,1,,,RHO GTPases activate CIT,4,High,1
Q9H7U1,Serine-rich coiled-coil domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CCSER2 PE=1 SV=2,0.034,2.343,1,1,2,1,834,93.5,6.87,672,,1,,cell organization and biogenesis,cytoskeleton,protein binding,,54462,ENSG00000107771.15,CCSER2; FAM190B,10,,,,0,High,1
Q96DX5,Ankyrin repeat and SOCS box protein 9 OS=Homo sapiens OX=9606 GN=ASB9 PE=1 SV=1,0.034,2.341,6,1,1,1,294,31.8,6.98,157,,1,,metabolic process;regulation of biological process;response to stimulus,cytosol;mitochondrion,protein binding,"Pf00023, Pf07525, Pf12796, Pf13606, Pf13637, Pf13857",140462,ENSG00000102048.15,ASB9,X,,,Antigen processing: Ubiquitination & Proteasome degradation; Neddylation,7,High,1
Q8N5F7,NF-kappa-B-activating protein OS=Homo sapiens OX=9606 GN=NKAP PE=1 SV=1,0.034,2.339,4,1,3,1,415,47.1,10.11,621,,1,,cell differentiation;cell proliferation;metabolic process;regulation of biological process;response to stimulus,cytosol;nucleus,DNA binding;protein binding;RNA binding,Pf06047,79576,ENSG00000101882.9,NKAP,X,,,,0,High,1
Q13415,Origin recognition complex subunit 1 OS=Homo sapiens OX=9606 GN=ORC1 PE=1 SV=2,0.034,2.336,1,1,5,1,861,97.3,9.22,1271,,1,,metabolic process;regulation of biological process,cytosol;membrane;nucleus,DNA binding;nucleotide binding;protein binding,"Pf00004, Pf01426, Pf09079, Pf13191, Pf13401",4998,ENSG00000085840.12,ORC1,1,Cell cycle,Cell Cycle; Retinoblastoma (RB) in Cancer; G1 to S cell cycle control; DNA Replication,CDT1 association with the CDC6:ORC:origin complex; Regulation of DNA replication; Activation of the pre-replicative complex; Association of licensing factors with the pre-replicative complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication; Orc1 removal from chromatin; M/G1 Transition; Activation of ATR in response to replication stress; Activation of E2F1 target genes at G1/S; CDC6 association with the ORC:origin complex; Removal of licensing factors from origins,31,High,1
Q9Y4L5,E3 ubiquitin-protein ligase RNF115 OS=Homo sapiens OX=9606 GN=RNF115 PE=1 SV=2,0.034,2.335,5,1,4,1,304,33.7,5.69,1106,,1,,metabolic process;regulation of biological process,cytoplasm;cytosol,catalytic activity;metal ion binding;protein binding,"Pf00097, Pf12678, Pf13639, Pf13920, Pf13923, Pf14369, Pf14634",27246,ENSG00000265491.4,RNF115; LOC101060478,1,,,Antigen processing: Ubiquitination & Proteasome degradation,4,High,1
Q13434,Putative E3 ubiquitin-protein ligase makorin-4 OS=Homo sapiens OX=9606 GN=MKRN4P PE=5 SV=1,0.034,2.335,2,1,1,1,485,52.9,5.16,371,,1,,metabolic process,,catalytic activity;metal ion binding;protein binding,"Pf12678, Pf13639",7682,,MKRN4P,X,,,,0,High,1
Q9UBC0,Hepatocyte nuclear factor 6 OS=Homo sapiens OX=9606 GN=ONECUT1 PE=2 SV=1,0.034,2.33,2,1,4,1,465,51,9.69,1222,,1,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,nucleus,DNA binding,"Pf00046, Pf02376, Pf05920",3175,ENSG00000169856.8,ONECUT1,15,Maturity onset diabetes of the young; Signaling pathways regulating pluripotency of stem cells,Endoderm Differentiation,Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; Regulation of gene expression in early pancreatic precursor cells,7,High,1
Q8WWA1,Transmembrane protein 40 OS=Homo sapiens OX=9606 GN=TMEM40 PE=1 SV=2,0.034,2.329,6,1,2,1,233,25.5,5.59,644,,1,,,membrane,,,55287,ENSG00000088726.15,TMEM40,3,,,,0,High,1
Q6P4R8,Nuclear factor related to kappa-B-binding protein OS=Homo sapiens OX=9606 GN=NFRKB PE=1 SV=2,0.034,2.328,1,1,11,1,1299,138.9,9.25,2108,,1,,defense response;metabolic process;regulation of biological process;response to stimulus,nucleus,DNA binding;protein binding,Pf14465,4798,ENSG00000170322.14,NFRKB,11,,Overview of nanoparticle effects,UCH proteinases; DNA Damage Recognition in GG-NER,9,High,1
O95294,RasGAP-activating-like protein 1 OS=Homo sapiens OX=9606 GN=RASAL1 PE=1 SV=3,0.034,2.326,1,1,3,1,804,90,6.51,1503,,1,,cell differentiation;metabolic process;regulation of biological process;response to stimulus,cytosol;membrane,enzyme regulator activity;metal ion binding;protein binding,"Pf00168, Pf00169, Pf00616, Pf00779",8437,ENSG00000111344.11,RASAL1,12,Ras signaling pathway,,Regulation of RAS by GAPs; Signaling by RAS mutants; Interleukin-20 family signaling,14,High,1
Q63HQ0,AP-1 complex-associated regulatory protein OS=Homo sapiens OX=9606 GN=AP1AR PE=1 SV=1,0.034,2.325,3,1,3,1,302,34.3,4.87,1036,,1,,regulation of biological process;transport,cytosol;endosome;Golgi,protein binding,,55435,ENSG00000138660.11,AP1AR,4,,,,0,High,1
Q9NZI6,Transcription factor CP2-like protein 1 OS=Homo sapiens OX=9606 GN=TFCP2L1 PE=1 SV=1,0.034,2.324,2,1,1,1,479,54.6,7.01,283,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;membrane;mitochondrion;nucleus,DNA binding,Pf04516,29842,ENSG00000115112.7,TFCP2L1,2,,,,0,High,1
O60885,Bromodomain-containing protein 4 OS=Homo sapiens OX=9606 GN=BRD4 PE=1 SV=2,0.034,2.323,1,1,1,1,1362,152.1,9.19,228,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,chromosome;cytosol;nucleus,protein binding,Pf00439,23476,ENSG00000141867.17,BRD4,19,,,,0,High,1
Q4KMQ1,Taperin OS=Homo sapiens OX=9606 GN=TPRN PE=1 SV=2,0.035,2.32,2,1,11,1,711,75.5,7.25,2754,,1,,,,protein binding,"Pf13914, Pf13916",286262,ENSG00000176058.11,TPRN,9,,,,0,High,1
Q9NP87,DNA-directed DNA/RNA polymerase mu OS=Homo sapiens OX=9606 GN=POLM PE=1 SV=1,0.035,2.317,2,1,1,1,494,54.8,8.41,368,,1,,cell differentiation;metabolic process;response to stimulus,nucleus,catalytic activity;DNA binding;metal ion binding;protein binding,"Pf00533, Pf01909, Pf10391, Pf14716, Pf14791, Pf14792",27434,ENSG00000122678.16,POLM,7,Non-homologous end-joining,,Nonhomologous End-Joining (NHEJ),4,High,1
O95696,Bromodomain-containing protein 1 OS=Homo sapiens OX=9606 GN=BRD1 PE=1 SV=1,0.035,2.317,1,1,1,1,1058,119.4,8.6,339,,1,,cell organization and biogenesis;metabolic process;response to stimulus,nucleus,metal ion binding;protein binding,"Pf00439, Pf00628, Pf00855, Pf10513, Pf13771, Pf13831, Pf13832",23774,ENSG00000100425.18,BRD1,22,,Pathways Affected in Adenoid Cystic Carcinoma,HATs acetylate histones; Regulation of TP53 Activity through Acetylation,10,High,1
Q9H501,ESF1 homolog OS=Homo sapiens OX=9606 GN=ESF1 PE=1 SV=1,0.035,2.315,1,1,7,1,851,98.7,5.11,1989,,1,,metabolic process;regulation of biological process,nucleus,RNA binding,Pf08159,51575,ENSG00000089048.14,ESF1,20,,,,0,High,1
Q7L211,Protein ABHD13 OS=Homo sapiens OX=9606 GN=ABHD13 PE=2 SV=1,0.036,2.311,5,1,1,1,337,38.5,8.57,279,,1,,metabolic process,cytoplasm;membrane,catalytic activity,"Pf00561, Pf02230, Pf05448, Pf12695, Pf12697",84945,ENSG00000139826.5,ABHD13,13,,,,0,High,1
O00559,Receptor-binding cancer antigen expressed on SiSo cells OS=Homo sapiens OX=9606 GN=EBAG9 PE=1 SV=1,0.036,2.311,8,1,2,1,213,24.4,6.29,383,,1,,cell death;regulation of biological process,Golgi;membrane,enzyme regulator activity,Pf07946,9166,ENSG00000147654.14,EBAG9,8,,,,0,High,1
Q15329,Transcription factor E2F5 OS=Homo sapiens OX=9606 GN=E2F5 PE=1 SV=1,0.036,2.309,2,1,1,1,346,37.6,5.1,402,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;nucleus,DNA binding;protein binding,Pf02319,1875,ENSG00000133740.10,E2F5,8,Cell cycle; TGF-beta signaling pathway,Cell Cycle; Spinal Cord Injury; Preimplantation Embryo; TGF-beta Signaling Pathway; G1 to S cell cycle control,Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; Cyclin E associated events during G1/S transition ; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Activation of E2F1 target genes at G1/S; Cyclin D associated events in G1; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry,29,High,1
Q96P50,"Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ACAP3 PE=1 SV=2",0.036,2.308,1,1,3,1,834,92.4,5.99,632,,1,,regulation of biological process,,enzyme regulator activity;metal ion binding;protein binding,"Pf00023, Pf00169, Pf01412, Pf12796, Pf13606, Pf13637, Pf13857, Pf15413",116983,ENSG00000131584.18,ACAP3,1,Endocytosis,,,1,High,1
Q8TCX5,Rhophilin-1 OS=Homo sapiens OX=9606 GN=RHPN1 PE=1 SV=2,0.036,2.308,1,1,4,1,670,73.5,7.53,1357,,1,,,,,,,,,,,,,0,High,1
P01106,Myc proto-oncogene protein OS=Homo sapiens OX=9606 GN=MYC PE=1 SV=1,0.036,2.308,2,1,2,1,439,48.8,5.49,664,,1,,cell death;cell organization and biogenesis;cellular homeostasis;metabolic process;regulation of biological process;response to stimulus;transport,cytosol;nucleus,DNA binding;protein binding,"Pf00010, Pf01056, Pf02344",4609,ENSG00000136997.16,MYC,8,Thyroid cancer; Pathways in cancer; Chronic myeloid leukemia; Proteoglycans in cancer; Endometrial cancer; TGF-beta signaling pathway; Cell cycle; Thyroid hormone signaling pathway; Epstein-Barr virus infection; Transcriptional misregulation in cancer; Breast cancer; Hepatitis B; Signaling pathways regulating pluripotency of stem cells; HTLV-I infection; Hippo signaling pathway; Small cell lung cancer; Colorectal cancer; Central carbon metabolism in cancer; PI3K-Akt signaling pathway; Wnt signaling pathway; Acute myeloid leukemia; Bladder cancer; ErbB signaling pathway; MicroRNAs in cancer; Jak-STAT signaling pathway; MAPK signaling pathway,IL-5 Signaling Pathway; miRNA Regulation of DNA Damage Response; miRNAs involved in DNA damage response; TP53 Network; Integrated Cancer pathway; Integrated Breast Cancer Pathway; Human Thyroid Stimulating Hormone (TSH) signaling pathway; Prolactin Signaling Pathway; IL-7 Signaling Pathway; Neural Crest Differentiation; Metastatic brain tumor; B Cell Receptor Signaling Pathway; Gastric cancer network 2; Spinal Cord Injury; Retinoblastoma (RB) in Cancer; Apoptosis; Aryl Hydrocarbon Receptor; Bladder Cancer; Ectoderm Differentiation; PPAR Alpha Pathway; Rac1/Pak1/p38/MMP-2 pathway; Wnt Signaling Pathway Netpath; Imatinib and Chronic Myeloid Leukemia; Hepatitis C and Hepatocellular Carcinoma; TGF-beta Signaling Pathway; Association Between Physico-Chemical Features and Toxicity Associated Pathways; MAPK Signaling Pathway; Regulation of Apoptosis by Parathyroid Hormone-related Protein; Wnt Signaling Pathway and Pluripotency; p38 MAPK Signaling Pathway; Wnt Signaling Pathway; G1 to S cell cycle control; IL-2 Signaling Pathway; Notch Signaling Pathway; ErbB Signaling Pathway; DNA Damage Response; DNA Damage Response (only ATM dependent),RUNX3 regulates WNT signaling; TFAP2 (AP-2) family regulates transcription of cell cycle factors; NOTCH1 Intracellular Domain Regulates Transcription; Ub-specific processing proteases; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Cyclin A:Cdk2-associated events at S phase entry; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Cyclin E associated events during G1/S transition ; Binding of TCF/LEF:CTNNB1 to target gene promoters; Constitutive Signaling by NOTCH1 PEST Domain Mutants; MAPK6/MAPK4 signaling; Interleukin-4 and 13 signaling; Transcription of E2F targets under negative control by DREAM complex,108,High,1
Q8WVE0,EEF1A lysine methyltransferase 1 OS=Homo sapiens OX=9606 GN=EEF1AKMT1 PE=1 SV=1,0.036,2.307,3,1,4,1,214,24.5,4.55,1207,,1,,metabolic process,cytoplasm;cytosol,catalytic activity,Pf10237,221143,ENSG00000150456.10,N6AMT2; EEF1AKMT1,13,,,Protein methylation,3,High,1
O43688,Phospholipid phosphatase 2 OS=Homo sapiens OX=9606 GN=PLPP2 PE=1 SV=1,0.036,2.307,7,1,4,1,288,32.6,8.35,634,,1,,metabolic process;regulation of biological process;response to stimulus,membrane,catalytic activity;protein binding,Pf01569,8612,ENSG00000141934.9,PPAP2C; PLPP2,19,Metabolic pathways; Sphingolipid metabolism; Glycerophospholipid metabolism; Phospholipase D signaling pathway; Fat digestion and absorption; Fc gamma R-mediated phagocytosis; Choline metabolism in cancer; Glycerolipid metabolism; Ether lipid metabolism,Triacylglyceride Synthesis,Sphingolipid de novo biosynthesis,14,High,1
P15538,"Cytochrome P450 11B1, mitochondrial OS=Homo sapiens OX=9606 GN=CYP11B1 PE=1 SV=5",0.036,2.306,3,1,1,1,503,57.5,9.32,277,,1,,metabolic process;response to stimulus,membrane;mitochondrion,catalytic activity;metal ion binding,Pf00067,1584,ENSG00000160882.11,CYP11B1,8,Steroid hormone biosynthesis; Metabolic pathways,Corticotropin-releasing hormone signaling pathway; Oxidation by Cytochrome P450; Metapathway biotransformation,Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4); Glucocorticoid biosynthesis; Endogenous sterols,18,High,1
O60656,UDP-glucuronosyltransferase 1-9 OS=Homo sapiens OX=9606 GN=UGT1A9 PE=1 SV=1,0.036,2.305,2,1,2,1,530,59.9,7.9,658,,1,,metabolic process;regulation of biological process,endoplasmic reticulum;membrane,catalytic activity;enzyme regulator activity;protein binding,"Pf00201, Pf04101",54600,ENSG00000241119.1,UGT1A9,2,Ascorbate and aldarate metabolism; Metabolic pathways; Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450; Steroid hormone biosynthesis; Pentose and glucuronate interconversions; Retinol metabolism; Drug metabolism - other enzymes; Chemical carcinogenesis; Porphyrin and chlorophyll metabolism,Nicotine Metabolism; Irinotecan Pathway; Aryl Hydrocarbon Receptor Pathway; Constitutive Androstane Receptor Pathway; PPAR Alpha Pathway; NRF2 pathway; Arylamine metabolism; Estrogen metabolism; Glucuronidation; Metapathway biotransformation,Glucuronidation; PPARA activates gene expression,27,High,1
O75140-1,Isoform 1 of GATOR complex protein DEPDC5 OS=Homo sapiens OX=9606 GN=DEPDC5,0.036,2.305,1,1,2,1,1572,177.8,6.73,781,,1,,cell communication;regulation of biological process;response to stimulus,cytosol;membrane;vacuole,enzyme regulator activity;protein binding,"Pf00610, Pf12257",9681,ENSG00000100150.16,DEPDC5,22,,,,0,High,1
P0DPB6,DNA-directed RNA polymerases I and III subunit RPAC2 OS=Homo sapiens OX=9606 GN=POLR1D PE=1 SV=1,0.036,2.3,7,1,2,1,133,15.2,5.8,469,,1,,,,,,,,,,,,,0,High,1
P41159,Leptin OS=Homo sapiens OX=9606 GN=LEP PE=1 SV=1,0.036,2.299,11,1,1,1,167,18.6,6.37,328,,1,,cell communication;cell differentiation;metabolic process;regulation of biological process;reproduction;response to stimulus;transport,cytoplasm;extracellular,protein binding,Pf02024,3952,ENSG00000174697.4,LEP,7,Non-alcoholic fatty liver disease (NAFLD); Neuroactive ligand-receptor interaction; AMPK signaling pathway; Cytokine-cytokine receptor interaction; Adipocytokine signaling pathway; Jak-STAT signaling pathway,AMP-activated Protein Kinase (AMPK) Signaling; Leptin signaling pathway; Adipogenesis; Spinal Cord Injury; Differentiation of white and brown adipocyte; Transcription factor regulation in adipogenesis; Leptin and adiponectin; Leptin Insulin Overlap,"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Synthesis, secretion, and deacylation of Ghrelin; Transcriptional regulation of white adipocyte differentiation; Signaling by Leptin",23,High,1
Q6ZS30,Neurobeachin-like protein 1 OS=Homo sapiens OX=9606 GN=NBEAL1 PE=2 SV=3,0.036,2.298,0,1,5,1,2694,307,6.44,1950,,1,,,,protein binding,"Pf00400, Pf02138, Pf13385, Pf14844",65065,ENSG00000144426.18,NBEAL1,2,,,,0,High,1
Q9UHC1,DNA mismatch repair protein Mlh3 OS=Homo sapiens OX=9606 GN=MLH3 PE=1 SV=3,0.036,2.297,1,1,2,1,1453,163.6,6.73,985,,1,,cell organization and biogenesis;metabolic process;response to stimulus,chromosome;nucleus,catalytic activity;DNA binding;nucleotide binding;protein binding,"Pf01119, Pf02518, Pf08676",27030,ENSG00000119684.15,MLH3,14,Mismatch repair,,Meiotic recombination,5,High,1
Q15834,Coiled-coil domain-containing protein 85B OS=Homo sapiens OX=9606 GN=CCDC85B PE=1 SV=2,0.037,2.295,5,1,1,1,202,22.1,5.08,295,,1,,cell differentiation;metabolic process;regulation of biological process,cytoplasm;cytoskeleton;nucleus,protein binding,Pf10226,11007,ENSG00000175602.3,CCDC85B,11,,,,0,High,1
Q13164,Mitogen-activated protein kinase 7 OS=Homo sapiens OX=9606 GN=MAPK7 PE=1 SV=2,0.037,2.293,1,1,21,1,816,88.3,5.88,6291,,1,,cell differentiation;cellular component movement;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;nucleotide binding;protein binding;signal transducer activity,"Pf00069, Pf01636, Pf07714",5598,ENSG00000166484.19,MAPK7,17,Oxytocin signaling pathway; MicroRNAs in cancer; GnRH signaling pathway; MAPK signaling pathway; Gap junction; Neurotrophin signaling pathway,MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated Cell Adhesion; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Signal Transduction of S1P Receptor; Cardiac Hypertrophic Response; Focal Adhesion; MAPK Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; ESC Pluripotency Pathways; EGF/EGFR Signaling Pathway; Insulin Signaling,ERKs are inactivated; Activated TLR4 signalling; Signaling by GPCR; Signalling to ERK5; Gastrin-CREB signalling pathway via PKC and MAPK; RET signaling; Senescence-Associated Secretory Phenotype (SASP),58,High,1
Q96SL4,Glutathione peroxidase 7 OS=Homo sapiens OX=9606 GN=GPX7 PE=1 SV=1,0.037,2.292,4,1,2,1,187,21,8.27,761,,1,,metabolic process;response to stimulus,endoplasmic reticulum;extracellular;organelle lumen,antioxidant activity;catalytic activity;protein binding,"Pf00255, Pf00578",2882,ENSG00000116157.5,GPX7,1,Glutathione metabolism; Arachidonic acid metabolism; Thyroid hormone synthesis,One carbon metabolism and related pathways,Detoxification of Reactive Oxygen Species,7,High,1
Q8TCG1,Protein CIP2A OS=Homo sapiens OX=9606 GN=CIP2A PE=1 SV=2,0.037,2.286,1,1,12,1,905,102.1,6.23,4134,,1,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;membrane,catalytic activity;motor activity;protein binding,"Pf00769, Pf01576, Pf02463, Pf04111, Pf05103, Pf05483, Pf05557, Pf05667, Pf06637, Pf07111, Pf07888, Pf08317, Pf08614, Pf10174, Pf12072, Pf12128, Pf13166, Pf13476, Pf13868, Pf13870, Pf14257, Pf14943",57650,ENSG00000163507.13,KIAA1524; CIP2A,3,,,,0,High,1
Q9HB09,Bcl-2-like protein 12 OS=Homo sapiens OX=9606 GN=BCL2L12 PE=1 SV=1,0.037,2.285,2,1,8,1,334,36.8,9.22,3611,,1,,cell death;regulation of biological process,membrane;nucleus,protein binding,,83596,ENSG00000126453.9,BCL2L12,19,,Regulation of Apoptosis by Parathyroid Hormone-related Protein,,1,High,1
Q9Y2R4,Probable ATP-dependent RNA helicase DDX52 OS=Homo sapiens OX=9606 GN=DDX52 PE=1 SV=3,0.037,2.284,1,1,5,1,599,67.5,9.67,1479,,1,,metabolic process,cytoplasm;membrane;nucleus,catalytic activity;DNA binding;nucleotide binding;RNA binding,"Pf00176, Pf00270, Pf00271, Pf04851, Pf13307",11056,ENSG00000277594.2,DDX52,17; CHR_HSCHR17_7_CTG4,,,Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol,5,High,1
Q6P179,Endoplasmic reticulum aminopeptidase 2 OS=Homo sapiens OX=9606 GN=ERAP2 PE=1 SV=2,0.038,2.282,2,1,4,1,960,110.4,6.71,1912,,1,,cell communication;metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;membrane;organelle lumen,catalytic activity;metal ion binding,"Pf01433, Pf11838, Pf13485",64167,ENSG00000164308.16,ERAP2,5,,,"Antigen Presentation: Folding, assembly and peptide loading of class I MHC",4,High,1
Q12962,Transcription initiation factor TFIID subunit 10 OS=Homo sapiens OX=9606 GN=TAF10 PE=1 SV=1,0.038,2.282,4,1,14,1,218,21.7,6.57,4641,,1,,cell death;cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;nucleus,catalytic activity;DNA binding;protein binding,Pf03540,6881,ENSG00000166337.9,TAF10,11,Herpes simplex infection; Basal transcription factors,,Ub-specific processing proteases; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; HATs acetylate histones; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Initiation; HIV Transcription Initiation; RNA Polymerase II Pre-transcription Events; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II HIV Promoter Escape,28,High,1
P49917,DNA ligase 4 OS=Homo sapiens OX=9606 GN=LIG4 PE=1 SV=2,0.038,2.281,2,1,1,1,911,103.9,7.96,200,,1,,cell death;cell differentiation;cell division;cell organization and biogenesis;cell proliferation;metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;cytosol;membrane;nucleus,catalytic activity;DNA binding;metal ion binding;nucleotide binding;protein binding,"Pf00533, Pf01068, Pf01331, Pf04675, Pf04679, Pf11411",3981,ENSG00000174405.13,LIG4,13,Non-homologous end-joining,,2-LTR circle formation; Nonhomologous End-Joining (NHEJ),11,High,1
Q96KM6,Zinc finger protein 512B OS=Homo sapiens OX=9606 GN=ZNF512B PE=1 SV=1,0.038,2.281,2,1,1,1,892,97.2,9.83,372,,1,,metabolic process;regulation of biological process,nucleus,DNA binding;metal ion binding;protein binding,,57473,ENSG00000196700.8,ZNF512B,20,,,,0,High,1
P17735,Tyrosine aminotransferase OS=Homo sapiens OX=9606 GN=TAT PE=1 SV=1,0.038,2.279,2,1,1,1,454,50.4,6.3,414,,1,,metabolic process;response to stimulus,cytosol;mitochondrion,catalytic activity;protein binding,"Pf00155, Pf00266, Pf01041, Pf01053, Pf07706",6898,ENSG00000198650.10,TAT,16,"Biosynthesis of amino acids; Phenylalanine, tyrosine and tryptophan biosynthesis; Metabolic pathways; Phenylalanine metabolism; Cysteine and methionine metabolism; Ubiquinone and other terpenoid-quinone biosynthesis; Tyrosine metabolism",Amino Acid metabolism,Phenylalanine and tyrosine catabolism,12,High,1
Q13087,Protein disulfide-isomerase A2 OS=Homo sapiens OX=9606 GN=PDIA2 PE=1 SV=2,0.038,2.279,2,1,1,1,525,58.2,4.98,296,,1,,cellular homeostasis;metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;organelle lumen,catalytic activity;protein binding,"Pf00085, Pf13098, Pf13848, Pf13899, Pf13905",64714,ENSG00000185615.15,PDIA2,16,,Statin Pathway,,1,High,1
O76054,SEC14-like protein 2 OS=Homo sapiens OX=9606 GN=SEC14L2 PE=1 SV=1,0.038,2.276,3,1,14,1,403,46.1,7.84,3464,,1,,metabolic process;regulation of biological process;transport,cytoplasm;cytosol;nucleus,transporter activity,"Pf00650, Pf03765, Pf13716, Pf13897",23541,ENSG00000100003.17,SEC14L2,22,,,,0,High,1
Q16825,Tyrosine-protein phosphatase non-receptor type 21 OS=Homo sapiens OX=9606 GN=PTPN21 PE=1 SV=2,0.039,2.274,1,1,1,1,1174,133.2,7.9,450,,1,,metabolic process,cytoplasm;cytoskeleton,catalytic activity;protein binding,"Pf00102, Pf00373, Pf09379, Pf09380",11099,ENSG00000070778.12,PTPN21,14,,,,0,High,1
Q6F5E8,"Capping protein, Arp2/3 and myosin-I linker protein 2 OS=Homo sapiens OX=9606 GN=CARMIL2 PE=1 SV=2",0.039,2.274,1,1,13,1,1435,154.6,6.76,3841,,1,,cell organization and biogenesis;cellular component movement;regulation of biological process,cytoplasm;cytoskeleton;endosome;membrane,protein binding,,146206,ENSG00000159753.13,RLTPR; CARMIL2,16,,,,0,High,1
O14966,Ras-related protein Rab-7L1 OS=Homo sapiens OX=9606 GN=RAB29 PE=1 SV=1,0.039,2.272,5,1,3,1,203,23.1,7.18,681,,1,,cell differentiation;cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cytoplasm;cytoskeleton;cytosol;endosome;Golgi;membrane;mitochondrion;vacuole,catalytic activity;nucleotide binding;protein binding,"Pf00025, Pf00071, Pf08477",8934,ENSG00000117280.12,RAB7L1; RAB29,1,,,RAB geranylgeranylation,3,High,1
P30291,Wee1-like protein kinase OS=Homo sapiens OX=9606 GN=WEE1 PE=1 SV=2,0.039,2.268,1,1,2,1,646,71.6,6.77,682,,1,,cell division;cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf07714",7465,ENSG00000166483.10,WEE1,11,Cell cycle,Cell Cycle; Retinoblastoma (RB) in Cancer; G1 to S cell cycle control,G2/M DNA replication checkpoint; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Cyclin E associated events during G1/S transition ; Polo-like kinase mediated events; Cyclin A:Cdk2-associated events at S phase entry; Factors involved in megakaryocyte development and platelet production; Cyclin A/B1/B2 associated events during G2/M transition,22,High,1
Q8WUA8,Tsukushin OS=Homo sapiens OX=9606 GN=TSKU PE=2 SV=3,0.039,2.268,2,1,2,1,353,37.8,6.87,643,,1,,cell organization and biogenesis;regulation of biological process;response to stimulus,extracellular;membrane,protein binding;receptor activity;signal transducer activity,"Pf12799, Pf13306, Pf13855",25987,ENSG00000182704.7,TSKU,11,,Ectoderm Differentiation,,1,High,1
Q92979,Ribosomal RNA small subunit methyltransferase NEP1 OS=Homo sapiens OX=9606 GN=EMG1 PE=1 SV=4,0.039,2.267,4,1,2,1,244,26.7,9.17,687,,1,,metabolic process,cytoplasm;nucleus,catalytic activity;protein binding;RNA binding,Pf03587,10436,ENSG00000126749.14,EMG1,12,Ribosome biogenesis in eukaryotes,,Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol,6,High,1
Q2NKQ1,Small G protein signaling modulator 1 OS=Homo sapiens OX=9606 GN=SGSM1 PE=1 SV=2,0.039,2.264,1,1,1,1,1148,129.6,5.69,365,,1,,regulation of biological process;transport,cytoplasm;cytosol;Golgi;membrane,enzyme regulator activity;protein binding,"Pf00566, Pf02759",129049,ENSG00000167037.18,SGSM1,22,,,,0,High,1
P55210,Caspase-7 OS=Homo sapiens OX=9606 GN=CASP7 PE=1 SV=1,0.039,2.263,3,1,3,1,303,34.3,6.07,1042,,1,,cell death;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,Pf00656,840,ENSG00000165806.19,CASP7,10,Apoptosis - multiple species; Apoptosis; Legionellosis; Alzheimer's disease; Pertussis; TNF signaling pathway; Non-alcoholic fatty liver disease (NAFLD),Nucleotide-binding Oligomerization Domain (NOD) pathway; TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway; Alzheimers Disease; TNF alpha Signaling Pathway; Allograft Rejection; Parkinsons Disease Pathway; Oncostatin M Signaling Pathway; Nanomaterial induced apoptosis; Apoptosis; Apoptosis-related network due to altered Notch3 in ovarian cancer; Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation; Rac1/Pak1/p38/MMP-2 pathway; Hepatitis C and Hepatocellular Carcinoma; MAPK Signaling Pathway; Apoptosis Modulation by HSP70; ERK Pathway in Huntington's Disease,SMAC-mediated dissociation of IAP:caspase complexes ; SMAC binds to IAPs ; Activation of caspases through apoptosome-mediated cleavage; Caspase-mediated cleavage of cytoskeletal proteins,35,High,1
Q9Y4K0,Lysyl oxidase homolog 2 OS=Homo sapiens OX=9606 GN=LOXL2 PE=1 SV=1,0.039,2.261,1,1,1,1,774,86.7,6.38,352,,1,,cell organization and biogenesis;cell proliferation;cellular component movement;metabolic process;regulation of biological process;response to stimulus;transport,chromosome;extracellular;membrane;nucleus,catalytic activity;metal ion binding;protein binding;receptor activity,"Pf00530, Pf01186",4017,ENSG00000134013.15,LOXL2,8,,Canonical and Non-Canonical TGF-B signaling,Elastic fibre formation; Crosslinking of collagen fibrils,6,High,1
Q96CN4,EVI5-like protein OS=Homo sapiens OX=9606 GN=EVI5L PE=1 SV=1,0.039,2.26,2,1,1,1,794,91.3,5.34,351,,1,,metabolic process;regulation of biological process;transport,,enzyme regulator activity;protein binding,"Pf00566, Pf02463, Pf04111, Pf05622, Pf05701, Pf06548, Pf06785, Pf07888, Pf09726, Pf10481, Pf12128, Pf13514",115704,ENSG00000142459.8,EVI5L,19,,,,0,High,1
P49842,Serine/threonine-protein kinase 19 OS=Homo sapiens OX=9606 GN=STK19 PE=1 SV=2,0.039,2.257,3,1,7,1,368,40.9,9.74,1251,,1,,metabolic process,nucleus,catalytic activity;nucleotide binding,Pf10494,8859,ENSG00000234947.8; ENSG00000226257.9; ENSG00000226033.9; ENSG00000236250.8; ENSG00000204344.14,STK19,6; CHR_HSCHR6_MHC_COX_CTG1; CHR_HSCHR6_MHC_DBB_CTG1; CHR_HSCHR6_MHC_MCF_CTG1; CHR_HSCHR6_MHC_SSTO_CTG1,,,,0,High,1
Q96A19,Coiled-coil domain-containing protein 102A OS=Homo sapiens OX=9606 GN=CCDC102A PE=1 SV=2,0.039,2.256,2,1,22,1,550,62.6,5.58,5790,,1,,,,catalytic activity;motor activity,"Pf01576, Pf05622",92922,ENSG00000135736.5,CCDC102A,16,,,,0,High,1
Q13287,N-myc-interactor OS=Homo sapiens OX=9606 GN=NMI PE=1 SV=2,0.04,2.247,3,1,16,1,307,35,5.34,5686,,1,,defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,protein binding,"Pf07292, Pf07334",9111,ENSG00000123609.10,NMI,2,,IL-2 Signaling Pathway,,1,High,1
Q5SZK8,FRAS1-related extracellular matrix protein 2 OS=Homo sapiens OX=9606 GN=FREM2 PE=1 SV=2,0.041,2.244,0,1,11,1,3169,350.9,5.03,3023,,1,,cell communication;development,membrane,metal ion binding,Pf03160,341640,,FREM2,13,,,,0,High,1
P56177,Homeobox protein DLX-1 OS=Homo sapiens OX=9606 GN=DLX1 PE=1 SV=3,0.041,2.244,6,1,4,1,255,27.3,9.7,1267,,1,,cell differentiation;development;metabolic process;regulation of biological process;response to stimulus,nucleus,DNA binding;protein binding,"Pf00046, Pf05920",1745,ENSG00000144355.14,DLX1,2,,,,0,High,1
Q9ULV0,Unconventional myosin-Vb OS=Homo sapiens OX=9606 GN=MYO5B PE=1 SV=3,0.041,2.243,0,1,10,1,1848,213.5,7.2,3977,,1,,metabolic process;transport,cytoplasm;endosome;Golgi;membrane,catalytic activity;motor activity;nucleotide binding;protein binding,"Pf00063, Pf00612, Pf01576, Pf01843, Pf02463, Pf04111, Pf05622, Pf07888, Pf07926, Pf09730, Pf12128, Pf13514, Pf13870, Pf14915",4645,ENSG00000167306.19,MYO5B,18,,,Vasopressin regulates renal water homeostasis via Aquaporins,3,High,1
O75054,Immunoglobulin superfamily member 3 OS=Homo sapiens OX=9606 GN=IGSF3 PE=2 SV=3,0.041,2.241,1,1,13,1,1194,135.1,6.07,3980,,1,,regulation of biological process;response to stimulus,cell surface;membrane,,Pf07679,3321,ENSG00000143061.17,IGSF3,1,,,,0,High,1
Q9NX07,tRNA selenocysteine 1-associated protein 1 OS=Homo sapiens OX=9606 GN=TRNAU1AP PE=1 SV=1,0.041,2.24,5,1,7,1,287,32.5,4.74,1877,,1,,metabolic process;regulation of biological process,cytoplasm;nucleus,RNA binding,"Pf00076, Pf13893, Pf14259",54952,ENSG00000180098.9,TRNAU1AP,1,,Selenium Metabolism and Selenoproteins,,1,High,1
Q6PCB6,Alpha/beta hydrolase domain-containing protein 17C OS=Homo sapiens OX=9606 GN=ABHD17C PE=1 SV=2,0.042,2.237,13,1,2,1,329,35.8,5.64,87,,1,,metabolic process;regulation of biological process,,catalytic activity,"Pf00326, Pf01738, Pf02230, Pf05728, Pf12695, Pf12697",58489,ENSG00000136379.11,ABHD17C; FAM108C1,15,,,,0,High,1
P30279,G1/S-specific cyclin-D2 OS=Homo sapiens OX=9606 GN=CCND2 PE=1 SV=1,0.042,2.237,3,1,17,1,289,33,5.19,5779,,1,,cell division;regulation of biological process;response to stimulus,chromosome;cytoplasm;cytosol;membrane;nucleus,protein binding,"Pf00134, Pf02984",894,ENSG00000118971.7,CCND2,12,Focal adhesion; MicroRNAs in cancer; PI3K-Akt signaling pathway; p53 signaling pathway; HTLV-I infection; FoxO signaling pathway; Measles; Jak-STAT signaling pathway; Wnt signaling pathway; Cell cycle; Hippo signaling pathway; Hedgehog signaling pathway; Prolactin signaling pathway; Transcriptional misregulation in cancer; Viral carcinogenesis,miRNA Regulation of DNA Damage Response; Cell Cycle; SRF and miRs in Smooth Muscle Differentiation and Proliferation; Signaling Pathways in Glioblastoma; Focal Adhesion; Ovarian Infertility Genes; Wnt Signaling Pathway and Pluripotency; Wnt Signaling Pathway; G1 to S cell cycle control; IL-2 Signaling Pathway; DNA Damage Response; DNA Damage Response (only ATM dependent),Regulation of RUNX1 Expression and Activity; Cyclin D associated events in G1,37,High,1
Q68CQ7,Glycosyltransferase 8 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=GLT8D1 PE=1 SV=2,0.042,2.236,3,1,2,1,371,41.9,9.35,584,,1,,metabolic process,Golgi;membrane,catalytic activity,Pf01501,55830,ENSG00000016864.18,GLT8D1,3,,,,0,High,1
P0DJ93,Small integral membrane protein 13 OS=Homo sapiens OX=9606 GN=SMIM13 PE=3 SV=1,0.042,2.234,33,1,2,1,91,10.3,6.67,167,,1,,,membrane,,,221710,ENSG00000224531.5,C6orf228; SMIM13,6,,,,0,High,1
Q9NTJ3,Structural maintenance of chromosomes protein 4 OS=Homo sapiens OX=9606 GN=SMC4 PE=1 SV=2,0.042,2.233,1,1,4,1,1288,147.1,6.79,1122,,1,,cell division;cell organization and biogenesis;metabolic process,chromosome;cytoplasm;cytosol;nucleus,nucleotide binding;protein binding,"Pf02463, Pf04012, Pf04111, Pf04156, Pf06470, Pf12128, Pf13166, Pf13304, Pf13476, Pf13555",10051,ENSG00000113810.15,SMC4,3,,,Condensation of Prometaphase Chromosomes; Condensation of Prophase Chromosomes,7,High,1
Q8NCF5,NFATC2-interacting protein OS=Homo sapiens OX=9606 GN=NFATC2IP PE=1 SV=1,0.042,2.232,2,1,1,1,419,45.8,6.6,326,,1,,metabolic process;regulation of biological process,cytoplasm;nucleus,protein binding,Pf11976,84901,ENSG00000176953.12,NFATC2IP,16,,,,0,High,1
P37275,Zinc finger E-box-binding homeobox 1 OS=Homo sapiens OX=9606 GN=ZEB1 PE=1 SV=2,0.042,2.232,1,1,7,1,1124,124,4.94,2222,,1,,cell differentiation;cell proliferation;metabolic process;regulation of biological process;response to stimulus,cytosol;nucleus,DNA binding;metal ion binding;protein binding,"Pf00046, Pf00096, Pf13465, Pf13894",6935,ENSG00000148516.21,ZEB1,10,MicroRNAs in cancer; Transcriptional misregulation in cancer,Hypoxia-mediated EMT and Stemness; TGF-beta Signaling Pathway; Hypertrophy Model,Interleukin-4 and 13 signaling,9,High,1
Q14296,Fas-activated serine/threonine kinase OS=Homo sapiens OX=9606 GN=FASTK PE=1 SV=1,0.042,2.229,1,1,1,1,549,61.1,9.89,375,,1,,cell death;metabolic process;regulation of biological process;response to stimulus,mitochondrion;organelle lumen,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf06743, Pf08368, Pf08373",10922,ENSG00000164896.19,FASTK,7,,,,0,High,1
P55199,RNA polymerase II elongation factor ELL OS=Homo sapiens OX=9606 GN=ELL PE=1 SV=1,0.042,2.228,1,1,4,1,621,68.2,9.33,1282,,1,,metabolic process;regulation of biological process,nucleus,protein binding,"Pf07303, Pf10390",8178,ENSG00000105656.12,ELL,19,,Interactome of polycomb repressive complex 2 (PRC2),RNA polymerase II transcribes snRNA genes; Transcription-Coupled Nucleotide Excision Repair (TC-NER); Tat-mediated HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; Formation of HIV-1 elongation complex containing HIV-1 Tat; HIV elongation arrest and recovery; TP53 Regulates Transcription of DNA Repair Genes; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; Formation of HIV elongation complex in the absence of HIV Tat; Pausing and recovery of Tat-mediated HIV elongation,27,High,1
Q8IYR2,SET and MYND domain-containing protein 4 OS=Homo sapiens OX=9606 GN=SMYD4 PE=2 SV=3,0.042,2.227,3,1,1,1,804,89.2,6.83,269,,1,,metabolic process,,catalytic activity;metal ion binding;protein binding,"Pf00856, Pf01753, Pf12968, Pf13414",114826,ENSG00000186532.11,SMYD4,17,,Histone Modifications,,1,High,1
P52735,Guanine nucleotide exchange factor VAV2 OS=Homo sapiens OX=9606 GN=VAV2 PE=1 SV=2,0.042,2.227,1,1,1,1,878,101.2,7.08,376,,1,,cell organization and biogenesis;cellular component movement;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,metal ion binding;protein binding,"Pf00017, Pf00018, Pf00130, Pf00169, Pf00307, Pf00621, Pf07653, Pf11971, Pf14604",7410,ENSG00000160293.16,VAV2,9,Fc gamma R-mediated phagocytosis; Focal adhesion; T cell receptor signaling pathway; cAMP signaling pathway; Leukocyte transendothelial migration; Rap1 signaling pathway; Proteoglycans in cancer; Natural killer cell mediated cytotoxicity; Chemokine signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Regulation of actin cytoskeleton,Integrin-mediated Cell Adhesion; Prolactin Signaling Pathway; B Cell Receptor Signaling Pathway; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Hepatitis C and Hepatocellular Carcinoma; VEGFA-VEGFR2 Signaling Pathway; Chemokine signaling pathway; Microglia Pathogen Phagocytosis Pathway; EGF/EGFR Signaling Pathway,G alpha (12/13) signalling events; FCERI mediated Ca+2 mobilization; Signal transduction by L1; Rho GTPase cycle; FCERI mediated MAPK activation; EPH-ephrin mediated repulsion of cells; DAP12 signaling; NRAGE signals death through JNK; GPVI-mediated activation cascade; VEGFR2 mediated vascular permeability; Regulation of actin dynamics for phagocytic cup formation; Signalling by NGF,53,High,1
P11169,"Solute carrier family 2, facilitated glucose transporter member 3 OS=Homo sapiens OX=9606 GN=SLC2A3 PE=1 SV=1",0.042,2.225,2,1,1,1,496,53.9,7.2,393,,1,,metabolic process;transport,membrane,transporter activity,"Pf00083, Pf07690, Pf13347",6515,ENSG00000059804.15,SLC2A3,12,,NRF2 pathway; Photodynamic therapy-induced HIF-1 survival signaling; Focal Adhesion-PI3K-Akt-mTOR-signaling pathway; Glycolysis and Gluconeogenesis,Vitamin C (ascorbate) metabolism; Neutrophil degranulation; Cellular hexose transport,14,High,1
Q6UX82,Ly6/PLAUR domain-containing protein 8 OS=Homo sapiens OX=9606 GN=LYPD8 PE=1 SV=2,0.042,2.224,3,1,60,1,237,25.2,5.72,21841,,1,,defense response;metabolic process;response to stimulus,extracellular;membrane,,,646627,ENSG00000259823.5,LYPD8,1,,,Post-translational modification: synthesis of GPI-anchored proteins,3,High,1
Q96CA5,Baculoviral IAP repeat-containing protein 7 OS=Homo sapiens OX=9606 GN=BIRC7 PE=1 SV=2,0.042,2.223,2,1,2,1,298,32.8,5.66,651,,1,,cell death;cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol;Golgi;nucleus,catalytic activity;enzyme regulator activity;metal ion binding;protein binding,"Pf00653, Pf13639, Pf13920, Pf13923, Pf14447, Pf14634",79444,ENSG00000101197.12,BIRC7,20,Small cell lung cancer; Apoptosis - multiple species; Ubiquitin mediated proteolysis; Toxoplasmosis; Pathways in cancer,,,5,High,1
Q8TAB3,Protocadherin-19 OS=Homo sapiens OX=9606 GN=PCDH19 PE=1 SV=3,0.042,2.222,1,1,5,1,1148,126.2,5.36,1999,,1,,cell communication,membrane,metal ion binding,"Pf00028, Pf08266",57526,ENSG00000165194.15,PCDH19,X,,,,0,High,1
Q8N7J2,APC membrane recruitment protein 2 OS=Homo sapiens OX=9606 GN=AMER2 PE=1 SV=3,0.042,2.222,1,1,2,1,671,69.5,6.99,1018,,1,,regulation of biological process;response to stimulus,membrane,protein binding,Pf09422,219287,ENSG00000165566.12,AMER2; FAM123A,13,,,,0,High,1
Q86UA6,RPA-interacting protein OS=Homo sapiens OX=9606 GN=RPAIN PE=1 SV=2,0.042,2.221,4,1,2,1,219,24.8,4.87,814,,1,,,,,,,,,,,,,0,High,1
Q92859,Neogenin OS=Homo sapiens OX=9606 GN=NEO1 PE=1 SV=2,0.042,2.22,1,1,1,1,1461,159.9,6.54,399,,1,,cellular component movement;regulation of biological process,Golgi;membrane,protein binding;receptor activity,"Pf00041, Pf00047, Pf06583, Pf07679, Pf07686, Pf13895, Pf13927",4756,ENSG00000067141.16,NEO1,15,Cell adhesion molecules (CAMs),,Netrin-1 signaling; CDO in myogenesis,6,High,1
Q8N556,Actin filament-associated protein 1 OS=Homo sapiens OX=9606 GN=AFAP1 PE=1 SV=2,0.042,2.22,1,1,1,1,730,80.7,8.68,262,,1,,regulation of biological process,cytoplasm;cytoskeleton;cytosol,protein binding,Pf00169,60312,ENSG00000196526.10,AFAP1,4,,,,0,High,1
Q9H0E7,Ubiquitin carboxyl-terminal hydrolase 44 OS=Homo sapiens OX=9606 GN=USP44 PE=1 SV=2,0.042,2.218,1,1,2,1,712,81.1,7.9,885,,1,,cell division;metabolic process;regulation of biological process,nucleus,catalytic activity;metal ion binding;protein binding,"Pf00443, Pf02148, Pf13423",84101,ENSG00000136014.11,USP44,12,,,Ub-specific processing proteases,4,High,1
Q9NQZ2,Something about silencing protein 10 OS=Homo sapiens OX=9606 GN=UTP3 PE=1 SV=1,0.042,2.217,1,1,2,1,479,54.5,5.62,888,,1,,cell organization and biogenesis;development;metabolic process,nucleus,protein binding;RNA binding,"Pf04000, Pf09368",57050,ENSG00000132467.3,UTP3,4,,,Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol,5,High,1
P32929,Cystathionine gamma-lyase OS=Homo sapiens OX=9606 GN=CTH PE=1 SV=3,0.042,2.217,2,1,7,1,405,44.5,6.7,2268,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol,catalytic activity;protein binding,"Pf00155, Pf00266, Pf01041, Pf01053",1491,ENSG00000116761.11,CTH,1,"Cysteine and methionine metabolism; Glycine, serine and threonine metabolism; Biosynthesis of amino acids; Metabolic pathways; Selenocompound metabolism",Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism; Trans-sulfuration pathway; Trans-sulfuration and one carbon metabolism; Amino Acid metabolism; One carbon metabolism and related pathways,"Metabolism of ingested SeMet, Sec, MeSec into H2Se; Degradation of cysteine and homocysteine; Cysteine formation from homocysteine",19,High,1
O95477,Phospholipid-transporting ATPase ABCA1 OS=Homo sapiens OX=9606 GN=ABCA1 PE=1 SV=3,0.043,2.216,0,1,2,1,2261,254.1,6.86,480,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;response to stimulus;transport,cell surface;Golgi;membrane,catalytic activity;nucleotide binding;protein binding;receptor activity;signal transducer activity;transporter activity,"Pf00005, Pf12698, Pf13304, Pf13732",19,ENSG00000165029.15,ABCA1,9,Fat digestion and absorption; ABC transporters,Selenium Micronutrient Network; Vitamin B12 Metabolism; Folate Metabolism; SREBF and miR33 in cholesterol and lipid homeostasis; Nuclear Receptors in Lipid Metabolism and Toxicity; Statin Pathway,Defective ABCA1 causes Tangier disease; PPARA activates gene expression; HDL assembly,20,High,1
Q8IV53,DENN domain-containing protein 1C OS=Homo sapiens OX=9606 GN=DENND1C PE=1 SV=1,0.043,2.215,6,1,2,1,801,87,5.67,9,,1,,,cytoplasm;cytosol,,"Pf02141, Pf03455, Pf03456",79958,ENSG00000205744.9,DENND1C,19,,,RAB GEFs exchange GTP for GDP on RABs,4,High,1
Q8N323,NXPE family member 1 OS=Homo sapiens OX=9606 GN=NXPE1 PE=2 SV=2,0.043,2.215,1,1,30,1,547,63.1,8.56,9856,,1,,,extracellular,,Pf06312,120400,ENSG00000095110.7,NXPE1,11,,,,0,High,1
P51813,Cytoplasmic tyrosine-protein kinase BMX OS=Homo sapiens OX=9606 GN=BMX PE=1 SV=1,0.043,2.211,1,1,2,1,675,78,8.5,811,,1,,cell death;cell differentiation;defense response;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding;signal transducer activity,"Pf00017, Pf00069, Pf00169, Pf00779, Pf07714, Pf14531",660,ENSG00000102010.14,BMX,X,,,Apoptotic cleavage of cellular proteins; Synthesis of PIPs at the plasma membrane,9,High,1
O95931,Chromobox protein homolog 7 OS=Homo sapiens OX=9606 GN=CBX7 PE=1 SV=1,0.043,2.209,8,1,2,1,251,28.3,9.44,532,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,cytosol;nucleus,protein binding,Pf00385,23492,ENSG00000100307.12,CBX7,22,,,,0,High,1
P29083,General transcription factor IIE subunit 1 OS=Homo sapiens OX=9606 GN=GTF2E1 PE=1 SV=2,0.043,2.208,3,1,2,1,439,49.4,4.82,993,,1,,metabolic process;regulation of biological process,cytosol;nucleus,DNA binding;metal ion binding;protein binding,"Pf02002, Pf08271, Pf11521",2960,ENSG00000153767.9,GTF2E1,3,Basal transcription factors; Epstein-Barr virus infection; Viral carcinogenesis,Eukaryotic Transcription Initiation,RNA polymerase II transcribes snRNA genes; RNA Polymerase II Transcription Initiation; HIV Transcription Initiation; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Pre-transcription Events; RNA Polymerase II Promoter Escape,20,High,1
Q5BKZ1,DBIRD complex subunit ZNF326 OS=Homo sapiens OX=9606 GN=ZNF326 PE=1 SV=2,0.043,2.204,3,1,1,1,582,65.6,5.15,227,,1,,metabolic process;regulation of biological process,nucleus;spliceosomal complex,DNA binding;metal ion binding;protein binding;RNA binding,Pf04988,284695,ENSG00000162664.16,ZNF326,1,,,,0,High,1
Q13277,Syntaxin-3 OS=Homo sapiens OX=9606 GN=STX3 PE=1 SV=3,0.044,2.198,3,1,1,1,289,33.1,5.44,289,,1,,cell organization and biogenesis;regulation of biological process;transport,membrane;vacuole,catalytic activity;protein binding,"Pf00804, Pf02485, Pf05739",6809,ENSG00000166900.15,STX3,11,SNARE interactions in vesicular transport; Synaptic vesicle cycle,Synaptic Vesicle Pathway,Other interleukin signaling,7,High,1
Q92823,Neuronal cell adhesion molecule OS=Homo sapiens OX=9606 GN=NRCAM PE=1 SV=3,0.044,2.198,1,1,4,1,1304,143.8,5.66,1052,,1,,cell organization and biogenesis;cellular component movement;regulation of biological process,extracellular;membrane,protein binding,"Pf00041, Pf00047, Pf07679, Pf07686, Pf08205, Pf13882, Pf13895, Pf13927",4897,ENSG00000091129.19,NRCAM,7,Cell adhesion molecules (CAMs),,NrCAM interactions; Neurofascin interactions; Interaction between L1 and Ankyrins,7,High,1
Q8TEB9,Rhomboid-related protein 4 OS=Homo sapiens OX=9606 GN=RHBDD1 PE=1 SV=1,0.044,2.198,5,1,1,1,315,35.8,8.24,280,,1,,cell death;cell differentiation;metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;membrane;mitochondrion,catalytic activity;protein binding,Pf01694,84236,ENSG00000144468.16,RHBDD1,2,,,,0,High,1
P55774,C-C motif chemokine 18 OS=Homo sapiens OX=9606 GN=CCL18 PE=1 SV=1,0.044,2.198,9,1,1,1,89,9.8,8.75,165,,1,,cell communication;cellular component movement;defense response;regulation of biological process;response to stimulus,extracellular,protein binding,Pf00048,6362,ENSG00000278006.2; ENSG00000278167.2; ENSG00000275385.1,CCL18; LOC101060271,17; CHR_HSCHR17_10_CTG4; CHR_HSCHR17_7_CTG4,Cytokine-cytokine receptor interaction; Chemokine signaling pathway,,,2,High,1
Q13309,S-phase kinase-associated protein 2 OS=Homo sapiens OX=9606 GN=SKP2 PE=1 SV=2,0.044,2.196,2,1,2,1,424,47.7,7.11,588,,1,,cell communication;cell proliferation;metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;protein binding,"Pf00646, Pf12937",6502,ENSG00000145604.15,SKP2,5,Herpes simplex infection; Pathways in cancer; FoxO signaling pathway; Cell cycle; mTOR signaling pathway; Ubiquitin mediated proteolysis; Small cell lung cancer; Epstein-Barr virus infection; Viral carcinogenesis,Cell Cycle; Retinoblastoma (RB) in Cancer; Imatinib and Chronic Myeloid Leukemia,Regulation of RUNX2 expression and activity; Ub-specific processing proteases; Cyclin D associated events in G1; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; SCF(Skp2)-mediated degradation of p27/p21,39,High,1
Q9Y483,Metal-response element-binding transcription factor 2 OS=Homo sapiens OX=9606 GN=MTF2 PE=1 SV=3,0.045,2.194,2,1,1,1,593,67,8.75,258,,1,,cell differentiation;cell organization and biogenesis;regulation of biological process,cytoplasm;nucleus,DNA binding;metal ion binding;protein binding,"Pf00628, Pf14061, Pf15057",22823,ENSG00000143033.17,MTF2,1,,Mesodermal Commitment Pathway; Interactome of polycomb repressive complex 2 (PRC2); Copper homeostasis,,3,High,1
Q86XN8,RNA-binding protein MEX3D OS=Homo sapiens OX=9606 GN=MEX3D PE=1 SV=3,0.045,2.194,2,1,3,1,651,64.8,5.35,667,,1,,regulation of biological process,cytoplasm;nucleus,metal ion binding;protein binding;RNA binding,"Pf00013, Pf13639, Pf13920, Pf13923",399664,ENSG00000181588.16,MEX3D,19,,,,0,High,1
Q7Z2E3,Aprataxin OS=Homo sapiens OX=9606 GN=APTX PE=1 SV=2,0.045,2.193,2,1,2,1,356,40.7,9.17,573,,1,,metabolic process;regulation of biological process;response to stimulus,chromosome;cytoplasm;nucleus,catalytic activity;DNA binding;metal ion binding;protein binding;RNA binding,"Pf01230, Pf11969",54840,ENSG00000137074.18,APTX,9,,,,0,High,1
Q658P3,Metalloreductase STEAP3 OS=Homo sapiens OX=9606 GN=STEAP3 PE=1 SV=2,0.045,2.192,1,1,1,1,488,54.6,8.6,443,,1,,cell death;metabolic process;regulation of biological process;transport,cytoplasm;endosome;membrane,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf01210, Pf03446, Pf03807",55240,ENSG00000115107.19,STEAP3,2,p53 signaling pathway,Iron metabolism in placenta; Copper homeostasis,Transferrin endocytosis and recycling; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release,12,High,1
Q8N5I9,Uncharacterized protein C12orf45 OS=Homo sapiens OX=9606 GN=C12orf45 PE=1 SV=2,0.045,2.189,5,1,4,1,185,20.1,5.22,1371,,1,,,,,Pf15370,121053,ENSG00000151131.10,C12orf45,12,,,,0,High,1
Q9UJJ9,N-acetylglucosamine-1-phosphotransferase subunit gamma OS=Homo sapiens OX=9606 GN=GNPTG PE=1 SV=1,0.045,2.185,5,1,2,1,305,34,6.95,625,,1,,metabolic process,extracellular;Golgi;membrane,catalytic activity;protein binding,"Pf07915, Pf13015",84572,ENSG00000090581.9,GNPTG,16,Lysosome,,,1,High,1
Q9BUD6,Spondin-2 OS=Homo sapiens OX=9606 GN=SPON2 PE=1 SV=3,0.045,2.181,3,1,4,1,331,35.8,5.52,1449,,1,,cellular component movement;defense response;regulation of biological process;response to stimulus,extracellular,metal ion binding;protein binding,Pf06468,10417,,SPON2,4,,,O-glycosylation of TSR domain-containing proteins; Defective B3GALTL causes Peters-plus syndrome (PpS),8,High,1
Q9H6E4,Coiled-coil domain-containing protein 134 OS=Homo sapiens OX=9606 GN=CCDC134 PE=1 SV=1,0.046,2.18,3,1,2,1,229,26.5,8.85,577,,1,,,cytoplasm;endoplasmic reticulum;extracellular;membrane;nucleus,,Pf15002,79879,ENSG00000100147.13,CCDC134,22,,,,0,High,1
Q9NV06,DDB1- and CUL4-associated factor 13 OS=Homo sapiens OX=9606 GN=DCAF13 PE=1 SV=2,0.046,2.179,2,1,6,1,445,51.4,9.19,2492,,1,,metabolic process,cytosol;nucleus,protein binding;RNA binding,"Pf00400, Pf04158",25879,ENSG00000164934.13,DCAF13,8,,,Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; Neddylation,8,High,1
Q5QJE6,Deoxynucleotidyltransferase terminal-interacting protein 2 OS=Homo sapiens OX=9606 GN=DNTTIP2 PE=1 SV=2,0.046,2.178,2,1,1,1,756,84.4,6.16,462,,1,,metabolic process;regulation of biological process,nucleus,RNA binding,Pf08698,30836,ENSG00000067334.13,DNTTIP2,1,,,,0,High,1
Q92800,Histone-lysine N-methyltransferase EZH1 OS=Homo sapiens OX=9606 GN=EZH1 PE=1 SV=2,0.046,2.178,1,1,4,1,747,85.2,7.72,1048,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,nucleus,catalytic activity;protein binding,"Pf00856, Pf11616",2145,ENSG00000108799.12,EZH1,17,Lysine degradation,Histone Modifications; Interactome of polycomb repressive complex 2 (PRC2),,3,High,1
P51811,Membrane transport protein XK OS=Homo sapiens OX=9606 GN=XK PE=1 SV=5,0.046,2.177,3,1,2,1,444,50.9,8.25,516,,1,,cell organization and biogenesis;cellular homeostasis;regulation of biological process;transport,membrane,protein binding;transporter activity,Pf09815,7504,ENSG00000047597.5,XK,X,,,Peptide ligand-binding receptors,5,High,1
Q04118,Basic salivary proline-rich protein 3 OS=Homo sapiens OX=9606 GN=PRB3 PE=1 SV=2,0.046,2.177,6,1,1,1,309,31,10.8,262,,1,,defense response;response to stimulus,extracellular,,,5544,,PRB3,12,,,,0,High,1
Q8NC69,BTB/POZ domain-containing protein KCTD6 OS=Homo sapiens OX=9606 GN=KCTD6 PE=1 SV=2,0.046,2.177,3,1,1,1,237,27.6,5.96,326,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,cytoplasm;cytosol,protein binding,Pf02214,200845,ENSG00000168301.12,KCTD6,3,,,Antigen processing: Ubiquitination & Proteasome degradation; RUNX1 regulates estrogen receptor mediated transcription; Neddylation,12,High,1
Q96AY4,Tetratricopeptide repeat protein 28 OS=Homo sapiens OX=9606 GN=TTC28 PE=1 SV=4,0.046,2.176,1,1,1,1,2481,270.7,6.89,324,,1,,cell division;regulation of biological process,cytoplasm;cytoskeleton,protein binding,"Pf00515, Pf07719, Pf12770, Pf13176, Pf13181, Pf13414, Pf13424",23331,ENSG00000100154.14,TTC28,22,,,,0,High,1
Q8TBC3,SH3KBP1-binding protein 1 OS=Homo sapiens OX=9606 GN=SHKBP1 PE=1 SV=2,0.046,2.175,2,1,2,1,707,76.3,8.28,506,,1,,cell organization and biogenesis;regulation of biological process,vacuole,protein binding,Pf02214,92799,ENSG00000160410.14,SHKBP1,19,,,,0,High,1
Q8TF01,Arginine/serine-rich protein PNISR OS=Homo sapiens OX=9606 GN=PNISR PE=1 SV=2,0.046,2.175,1,1,4,1,805,92.5,10.02,1157,,1,,,cytosol;nucleus,RNA binding,,25957,ENSG00000132424.14,PNISR,6,,,,0,High,1
Q5VV67,Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 OS=Homo sapiens OX=9606 GN=PPRC1 PE=1 SV=1,0.046,2.173,0,1,1,1,1664,177.4,6.51,293,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,nucleus,protein binding;RNA binding,"Pf00076, Pf13893, Pf14259",23082,ENSG00000148840.10,PPRC1,10,,Energy Metabolism; Mitochondrial Gene Expression,Transcriptional activation of mitochondrial biogenesis,5,High,1
Q9BZX2,Uridine-cytidine kinase 2 OS=Homo sapiens OX=9606 GN=UCK2 PE=1 SV=1,0.046,2.173,4,1,1,1,261,29.3,6.7,309,,1,,metabolic process,cytosol,catalytic activity;nucleotide binding,"Pf00485, Pf13207",7371,ENSG00000143179.14,UCK2,1,Drug metabolism - other enzymes; Pyrimidine metabolism; Metabolic pathways,Fluoropyrimidine Activity,Pyrimidine salvage,8,High,1
P24347,Stromelysin-3 OS=Homo sapiens OX=9606 GN=MMP11 PE=1 SV=3,0.046,2.173,1,1,1,1,488,54.6,6.87,355,,1,,cell organization and biogenesis;development;metabolic process;regulation of biological process,extracellular;organelle lumen,catalytic activity;metal ion binding,"Pf00045, Pf00413, Pf05572",4320,ENSG00000099953.9; ENSG00000275365.3,MMP11,22; CHR_HSCHR22_1_CTG7,,Matrix Metalloproteinases,Collagen degradation; Activation of Matrix Metalloproteinases,5,High,1
Q53LP3,Ankyrin repeat domain-containing protein SOWAHC OS=Homo sapiens OX=9606 GN=SOWAHC PE=1 SV=1,0.046,2.17,2,1,1,1,525,55.6,7.03,194,,1,,,,protein binding,"Pf00023, Pf12796, Pf13606, Pf13637, Pf13857",65124,ENSG00000198142.4,SOWAHC,2,,,,0,High,1
Q8N608,Inactive dipeptidyl peptidase 10 OS=Homo sapiens OX=9606 GN=DPP10 PE=1 SV=2,0.046,2.169,1,1,1,1,796,90.8,6.57,303,,1,,cell organization and biogenesis;metabolic process;regulation of biological process,membrane,catalytic activity;protein binding,"Pf00326, Pf00930, Pf01738, Pf02230",57628,ENSG00000175497.16,DPP10,2,,,,0,High,1
Q969M7,NEDD8-conjugating enzyme UBE2F OS=Homo sapiens OX=9606 GN=UBE2F PE=1 SV=1,0.047,2.167,9,1,3,1,185,21.1,6.79,686,,1,,metabolic process,cytoplasm;cytosol,catalytic activity;nucleotide binding;protein binding,Pf00179,140739,ENSG00000184182.18,UBE2F,2,Ubiquitin mediated proteolysis,Cell Cycle,Antigen processing: Ubiquitination & Proteasome degradation; Neddylation,9,High,1
A0A0A0MT89,Immunoglobulin kappa joining 1 OS=Homo sapiens OX=9606 GN=IGKJ1 PE=4 SV=2,0.047,2.166,67,1,3,1,12,1.4,8.84,911,,1,,,,,,,,,,,,,0,High,1
P51504,Zinc finger protein 80 OS=Homo sapiens OX=9606 GN=ZNF80 PE=2 SV=2,0.047,2.164,5,1,1,1,273,31.2,8.73,397,,1,,metabolic process;regulation of biological process,nucleus,DNA binding;metal ion binding,Pf13465,7634,ENSG00000174255.6,ZNF80,3,,,,0,High,1
Q9ULI3,Protein HEG homolog 1 OS=Homo sapiens OX=9606 GN=HEG1 PE=1 SV=3,0.047,2.163,1,1,1,1,1381,147.4,6.18,254,,1,,cell differentiation;cell organization and biogenesis;development;regulation of biological process,cell surface;extracellular;membrane,metal ion binding;protein binding,"Pf00008, Pf07645, Pf12947",57493,ENSG00000173706.12,HEG1,3,,,,0,High,1
Q9NXX6,Non-structural maintenance of chromosomes element 4 homolog A OS=Homo sapiens OX=9606 GN=NSMCE4A PE=1 SV=2,0.048,2.16,4,1,2,1,385,44.3,5.38,402,,1,,metabolic process;regulation of biological process;response to stimulus,chromosome;nucleus,protein binding,"Pf08743, Pf15412",54780,ENSG00000107672.14,NSMCE4A,10,,,SUMOylation of DNA damage response and repair proteins,5,High,1
Q8IUC8,Polypeptide N-acetylgalactosaminyltransferase 13 OS=Homo sapiens OX=9606 GN=GALNT13 PE=2 SV=2,0.048,2.159,3,1,2,1,556,64,6.83,684,,1,,metabolic process,Golgi;membrane,catalytic activity;metal ion binding,"Pf00535, Pf00652, Pf02709, Pf13632",114805,ENSG00000144278.14,GALNT13,2,Metabolic pathways; Mucin type O-glycan biosynthesis,,O-linked glycosylation of mucins,6,High,1
Q9BXY0,Protein MAK16 homolog OS=Homo sapiens OX=9606 GN=MAK16 PE=1 SV=2,0.048,2.159,2,1,2,1,300,35.3,5.38,633,,1,,metabolic process,nucleus,RNA binding,"Pf01778, Pf04874",84549,ENSG00000198042.10,MAK16,8,,,,0,High,1
Q96BZ9,TBC1 domain family member 20 OS=Homo sapiens OX=9606 GN=TBC1D20 PE=1 SV=1,0.048,2.156,2,1,1,1,403,45.8,6.86,311,,1,,cell organization and biogenesis;regulation of biological process;transport,endoplasmic reticulum;membrane,enzyme regulator activity;protein binding,Pf00566,128637,ENSG00000125875.13,TBC1D20,20,,,TBC/RABGAPs; COPII (Coat Protein 2) Mediated Vesicle Transport,10,High,1
Q99973,Telomerase protein component 1 OS=Homo sapiens OX=9606 GN=TEP1 PE=1 SV=2,0.048,2.154,0,1,2,1,2627,290.3,7.97,912,,1,,cell organization and biogenesis;metabolic process,chromosome;cytoplasm;nucleus;spliceosomal complex,catalytic activity;nucleotide binding;protein binding;RNA binding,"Pf00400, Pf05386, Pf05729, Pf05731, Pf13271",7011,ENSG00000129566.12,TEP1,14,,,,0,High,1
Q92786,Prospero homeobox protein 1 OS=Homo sapiens OX=9606 GN=PROX1 PE=1 SV=2,0.048,2.153,2,1,2,1,737,83.2,7.18,598,,1,,cell differentiation;cell organization and biogenesis;cell proliferation;cellular component movement;development;metabolic process;regulation of biological process;response to stimulus,cytoplasm;nucleus,DNA binding;protein binding,Pf05044,5629,ENSG00000117707.15,PROX1,1,,,,0,High,1
Q9BSK4,Protein fem-1 homolog A OS=Homo sapiens OX=9606 GN=FEM1A PE=1 SV=1,0.049,2.146,4,1,1,1,669,73.6,6.07,259,,1,,metabolic process;regulation of biological process,cytoplasm;cytosol,catalytic activity;protein binding,"Pf00023, Pf12796, Pf13606, Pf13637, Pf13857",55527,ENSG00000141965.4,FEM1A,19,,,Neddylation,3,High,1
Q86UP3,Zinc finger homeobox protein 4 OS=Homo sapiens OX=9606 GN=ZFHX4 PE=1 SV=1,0.049,2.146,0,1,22,1,3567,393.5,6.37,10559,,1,,metabolic process;regulation of biological process,nucleus,DNA binding;metal ion binding,"Pf00046, Pf05920",79776,,ZFHX4,8,,Mesodermal Commitment Pathway; Ectoderm Differentiation,,2,High,1
Q9ULF5,Zinc transporter ZIP10 OS=Homo sapiens OX=9606 GN=SLC39A10 PE=1 SV=2,0.049,2.143,5,1,3,1,831,94.1,6.76,117,,1,,cellular homeostasis;regulation of biological process;transport,membrane,transporter activity,"Pf02535, Pf14667",57181,ENSG00000196950.13,SLC39A10,2,,NRF2 pathway; Zinc homeostasis,Zinc influx into cells by the SLC39 gene family,8,High,1
Q8IXQ4,GPALPP motifs-containing protein 1 OS=Homo sapiens OX=9606 GN=GPALPP1 PE=1 SV=1,0.049,2.142,2,1,52,1,340,38.1,5.41,18793,,1,,,,,Pf12572,55425,ENSG00000133114.17,GPALPP1; KIAA1704,13,,,,0,High,1
Q9BQS7,Hephaestin OS=Homo sapiens OX=9606 GN=HEPH PE=1 SV=3,0.049,2.141,1,1,1,1,1158,130.4,5.99,371,,1,,cellular homeostasis;metabolic process;transport,membrane,catalytic activity;metal ion binding,"Pf00394, Pf07731, Pf07732",9843,ENSG00000089472.16,HEPH,X,Porphyrin and chlorophyll metabolism; Mineral absorption,,Metal ion SLC transporters; Iron uptake and transport,7,High,1
Q8N159,"N-acetylglutamate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=NAGS PE=1 SV=1",0.049,2.141,1,1,5,1,534,58.1,8.9,1677,,1,,metabolic process,mitochondrion;organelle lumen,catalytic activity,"Pf00696, Pf04768",162417,ENSG00000161653.10,NAGS,17,Biosynthesis of amino acids; 2-Oxocarboxylic acid metabolism; Arginine biosynthesis; Metabolic pathways,Urea cycle and metabolism of amino groups,Urea cycle,9,High,1
Q5VWJ9,Sorting nexin-30 OS=Homo sapiens OX=9606 GN=SNX30 PE=1 SV=1,0.05,2.14,3,1,1,1,437,49.6,5.35,367,,1,,cell organization and biogenesis;transport,cytoplasm;endosome,protein binding,"Pf00787, Pf03114",401548,ENSG00000148158.16,SNX30,9,,,,0,High,1
Q6ZS72,Uncharacterized protein PEAK3 OS=Homo sapiens OX=9606 GN=PEAK3 PE=2 SV=1,0.05,2.139,2,1,7,1,473,50.5,8.5,3024,,1,,metabolic process,cytoskeleton,catalytic activity,,374872,ENSG00000188305.5,C19orf35; PEAK3,19,,,,0,High,1
Q9NT68,Teneurin-2 OS=Homo sapiens OX=9606 GN=TENM2 PE=1 SV=3,0.05,2.134,1,1,4,1,2774,307.6,6.68,731,,1,,cell organization and biogenesis;cellular component movement;metabolic process;regulation of biological process;response to stimulus,endoplasmic reticulum;Golgi;membrane;nucleus,metal ion binding;protein binding,"Pf01500, Pf05593, Pf06484, Pf07974, Pf13715, Pf15636",57451,ENSG00000145934.16,TENM2,5,,,,0,High,1
Q13163,Dual specificity mitogen-activated protein kinase kinase 5 OS=Homo sapiens OX=9606 GN=MAP2K5 PE=1 SV=2,0.05,2.131,2,1,2,1,448,50.1,6.39,511,,1,,metabolic process;regulation of biological process;response to stimulus,cytoplasm;cytosol;nucleus,catalytic activity;metal ion binding;nucleotide binding;protein binding,"Pf00069, Pf00564, Pf07714, Pf14531",5607,ENSG00000137764.19,MAP2K5,15,Neurotrophin signaling pathway; MAPK signaling pathway; Gap junction; Oxytocin signaling pathway,MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated Cell Adhesion; Signaling Pathways in Glioblastoma; Brain-Derived Neurotrophic Factor (BDNF) signaling pathway; Cardiac Hypertrophic Response; Focal Adhesion; MAPK Signaling Pathway; Angiopoietin Like Protein 8 Regulatory Pathway; ESC Pluripotency Pathways; EGF/EGFR Signaling Pathway; Insulin Signaling,Signalling to ERK5,20,High,1
Q8WVK7,Spindle and kinetochore-associated protein 2 OS=Homo sapiens OX=9606 GN=SKA2 PE=1 SV=1,0.05,2.131,9,1,1,1,121,14.2,7.33,318,,1,,cell division;cell organization and biogenesis;regulation of biological process,chromosome;cytoplasm;cytoskeleton;cytosol,protein binding,,348235,ENSG00000182628.12,SKA2,17,,,Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins,16,High,1
Q9NQX4,Unconventional myosin-Vc OS=Homo sapiens OX=9606 GN=MYO5C PE=1 SV=2,0.05,2.13,0,1,1,1,1742,202.7,7.71,476,,1,,cell organization and biogenesis;metabolic process;regulation of biological process;transport,cytoplasm;cytoskeleton,catalytic activity;motor activity;nucleotide binding;protein binding;structural molecule activity;transporter activity,"Pf00038, Pf00063, Pf00612, Pf00769, Pf01496, Pf01540, Pf01576, Pf01843, Pf02463, Pf03961, Pf04111, Pf05483, Pf05557, Pf05622, Pf05667, Pf05769, Pf05911, Pf06008, Pf06160, Pf07888, Pf09726, Pf09731, Pf10174, Pf11932, Pf12128, Pf12252, Pf13166, Pf13514, Pf13654, Pf15619",55930,ENSG00000128833.12,MYO5C,15,,,,0,High,1