Supplemental Figure 1. Wall Thickness Distribution in (A) Healthy Volunteers and (B) Hypertrophic Cardiomyopathy

B

Supplemental Table 1. Baseline and Cardiovascular Magnetic Resonance Characteristics of Patients with Hypertrophic Cardiomyopathy Stratified by Sex-specific Thresholds
Group 1: Patients with maximal wall thickness  sex-specific thresholds
Group 2: Patients with maximal wall thickness < sex-specific thresholds

	Group 1
(n = 96)	Group 2
(n = 18)	P Value	
CLINICAL CHARACTERISTICS 		
Females, n (%)	27 (28)	4 (22)	0.774	
Age, years	54  12	45  16	0.008	
Height, m	1.67  0.08	1.70  0.09	0.239	
Weight, kg	71  13	73  18	0.493	
Body surface area, m2	1.79  0.18	1.83  0.24	0.403	
Systolic blood pressure, mm Hg	134  20	132  18	0.638	
Diastolic blood pressure, mm Hg	77  12	76  12	0.709	
Pathogenic gene mutation, n (%)	33 (34)	6 (33)	1.000	
CARDIOVASCULAR MAGNETIC RESONANCE CHARACTERISTICS	
Indexed LV EDV, mL/m2	79  12	84  10	0.072	
Indexed LV ESV, mL/m2	33  9	35  10	0.319	
Indexed LV SV, mL/m2	46  9	49  9	0.150	
Indexed LV mass, g/m2	85  26	61  11	<0.001	
LV ejection fraction, %	58  9	58  10	0.983	
Indexed RV EDV, mL/m2	71  15	81  20	0.012	
Indexed RV ESV, mL/m2	26  11	34  14	0.009	
Indexed RV SV, mL/m2	44  10	47  9	0.251	
RV ejection fraction, %	64  10	60  11	0.116	
Global longitudinal strain, %	−11.2  2.8	−14.5  2.9	<0.001	
Global radial strain, %	28.3  9.0	33.7  9.7	0.024	
Global circumferential strain, %	−16.5  3.5	−18.9  3.7	0.011	
LV mass/EDV	1.08  0.28	0.73  0.14	<0.001	
Max. wall thickness, mm	16.0  2.7	10.2  1.0	<0.001	
Asymmetric ratio	2.06  0.83	1.50  0.35	<0.001	
Nonischemic LGE, n (%)	79 (82)	8 (44)	0.002	
Native T1, ms	1,063  41	1,032  29	0.005	
Extracellular volume fraction, %	31.0  4.5	27.6  2.7	0.003	

Abbreviations: EDV = end-diastolic volume; ESV = end-systolic volume; LGE = late gadolinium enhancement; LV = left ventricular; RV = right ventricular; SV = stroke volume. 

Supplemental Table 2. Baseline and Cardiovascular Magnetic Resonance Characteristics of Patients with Hypertrophic Cardiomyopathy Stratified by Indexed Maximal Wall Thickness Threshold
Group 1: Patients with indexed maximal wall thickness  6.5mm/m2
Group 2: Patients with indexed maximal wall thickness < 6.5mm/m2

	Group 1
(n = 91)	Group 2
(n = 23)	P Value	
CLINICAL CHARACTERISTICS 		
Females, n (%)	 28 (31)	3 (13)	0.083	
Age, years	54  13	45  14	0.006	
Height, m	1.66  0.08	1.72  0.08	0.004	
Weight, kg	70  13	77  17	0.021	
Body surface area, m2	1.77  0.18	1.89  0.21	0.008	
Systolic blood pressure, mm Hg	134  21	134  16	0.972	
Diastolic blood pressure, mm Hg	77  12	76  11	0.679	
Pathogenic gene mutation, n (%)	32 (35)	7 (33)	0.716	
CARDIOVASCULAR MAGNETIC RESONANCE CHARACTERISTICS	
Indexed LV EDV, mL/m2	79  13	82  11	0.327	
Indexed LV ESV, mL/m2	33  9	33  10	0.841	
Indexed LV SV, mL/m2	45  9	49  8	0.109	
Indexed LV mass, g/m2	85  27	65  11	<0.001	
LV ejection fraction, %	58  9	60  9	0.298	
Indexed RV EDV, mL/m2	71  16	78  18	0.062	
Indexed RV ESV, mL/m2	27  11	31  13	0.107	
Indexed RV SV, mL/m2	44  9	47  8	0.201	
RV ejection fraction, %	64  10	62  10	0.481	
Global longitudinal strain, %	−11.1  2.7	−14.7  2.8	<0.001	
Global radial strain, %	27.9  9.0	34.2  9.1	0.005	
Global circumferential strain, %	−16.4  3.5	−19.1  3.5	0.003	
LV mass/EDV	1.08  0.30	0.83  0.17	<0.001	
Max. wall thickness, mm	16.1  2.7	10.9  1.4	<0.001	
Asymmetric ratio	2.11  0.83	1.45  0.26	<0.001	
Nonischemic LGE, n (%)	76 (84)	11 (48)	0.006	
Native T1, ms	1,067  41	1,031  26	0.001	
Extracellular volume fraction, %	31.3  4.5	27.6  2.5	<0.001	

Abbreviations: EDV = end-diastolic volume; ESV = end-systolic volume; LGE = late gadolinium enhancement; LV = left ventricular; RV = right ventricular; SV = stroke volume.