"Table S1. Genes differentially DNAm with passage and differentially expressed with differentiation but dependent on passage group. Columns are: gene name, Ensembl gene ID, low passage p value and q value for gene expression association to differentiation, high passage p value and q value for gene expression association to differentiation, CpGs associated to the gene which were hypermethylated or hypomethylated.",,,,,,, Gene,Ensembl gene name,Low Passage p value,Low Passage q value,High Passage p value,High Passage q value,Hypermethylated CpGs,Hypomethylated CpGs NR1D1,ENSG00000126368,3.8E-06,3.8E-05,0.054,0.072,NA,cg09019952 HSD17B12,ENSG00000149084,2.7E-05,0.00015,0.055,0.073,NA,cg26786893 CACNA2D2,ENSG00000007402,4.6E-05,0.00023,0.19,0.22,NA,"cg02223914, cg07158530, cg03838623" KLHL23,ENSG00000213160,9.9E-05,0.00041,0.072,0.092,NA,cg06714909 TPTEP1,ENSG00000100181,0.00011,0.00046,0.074,0.094,NA,cg11811863 RAB3B,ENSG00000169213,0.00014,0.00053,0.13,0.16,NA,cg01223789 FAM83G,ENSG00000188522,0.00017,0.00061,0.04,0.056,cg19328583,NA ZNF608,ENSG00000168916,0.00018,0.00064,0.17,0.2,NA,cg01793651 ECM1,ENSG00000143369,0.00019,0.00067,0.068,0.087,NA,cg16386293 DST,ENSG00000151914,0.00027,0.00089,0.063,0.082,NA,"cg10784258, cg05634622" CNTNAP1,ENSG00000108797,0.00029,0.00093,0.15,0.18,cg12432580,NA CLDN12,ENSG00000157224,0.00036,0.0011,0.056,0.074,NA,cg23498494 STMN3,ENSG00000197457,0.00037,0.0011,0.059,0.078,NA,cg18346693 SP3,ENSG00000172845,0.00043,0.0012,0.2,0.23,cg00414354,NA PNPLA7,ENSG00000130653,0.00054,0.0015,0.076,0.097,NA,"cg04990605, cg04683830, cg08298644, cg07517918, cg01894667" SWT1,ENSG00000116668,0.00063,0.0016,0.072,0.092,NA,cg06699494 ANXA2,ENSG00000182718,0.0007,0.0018,0.11,0.13,NA,cg13313836 CCDC88A,ENSG00000115355,0.001,0.0023,0.037,0.052,cg19521775,NA AZGP1,ENSG00000160862,0.0011,0.0024,0.064,0.084,NA,cg23880078 CDC6,ENSG00000094804,0.0011,0.0024,0.093,0.12,NA,cg17231373 RNF130,ENSG00000113269,0.0011,0.0025,0.18,0.2,NA,cg05314055 CTR9,ENSG00000198730,0.0012,0.0025,0.77,0.81,NA,cg04510330 FAM13A,ENSG00000138640,0.0012,0.0026,0.1,0.13,NA,cg20991003 SMIM3,ENSG00000256235,0.0012,0.0025,0.14,0.17,NA,cg14580211 PRR5L,ENSG00000135362,0.0013,0.0027,0.13,0.15,NA,"cg24684192, cg08026078" TBC1D24,ENSG00000162065,0.0013,0.0027,0.046,0.063,cg03422651,NA TMEM63C,ENSG00000165548,0.0013,0.0027,0.063,0.083,cg01637125,"cg01086910, cg00283934" ABCG1,ENSG00000160179,0.0014,0.0028,0.069,0.089,NA,cg20075442 FRMD4A,ENSG00000151474,0.0014,0.0029,0.096,0.12,cg01395831,"cg25045228, cg21814905, cg11679124, cg11756300, cg18031010, cg24757943, cg22745143, cg02242858, cg15747045" SLC20A1,ENSG00000144136,0.0015,0.0031,0.17,0.2,NA,"cg06121808, cg26703507" MCF2L,ENSG00000126217,0.0017,0.0032,0.076,0.096,"cg16299159, cg00543684",NA PLEKHH3,ENSG00000068137,0.0017,0.0033,0.11,0.14,cg24881289,NA AACS,ENSG00000081760,0.0018,0.0035,0.066,0.086,"cg02302082, cg24756065, cg06980047, cg25618890",NA SLC13A3,ENSG00000158296,0.0018,0.0034,0.21,0.25,NA,cg08714286 GRK4,ENSG00000125388,0.0019,0.0036,0.073,0.093,NA,"cg08968034, cg03861089" PER2,ENSG00000132326,0.002,0.0036,0.058,0.076,cg11903188,NA WDTC1,ENSG00000142784,0.002,0.0038,1,1,NA,cg26617030 RASSF3,ENSG00000153179,0.0027,0.0047,0.16,0.19,NA,cg05055371 RASSF1,ENSG00000068028,0.0028,0.0049,0.059,0.078,NA,cg00980904 SPRN,ENSG00000203772,0.0028,0.0048,0.078,0.099,NA,cg17043720 COL1A1,ENSG00000108821,0.0029,0.005,0.18,0.21,NA,cg02186748 DGKE,ENSG00000153933,0.0032,0.0053,0.041,0.057,"cg12963453, cg16112969",NA MAST4,ENSG00000069020,0.0032,0.0054,0.11,0.13,cg24811598,cg16113371 PRDM16,ENSG00000142611,0.0032,0.0053,0.23,0.26,NA,"cg11837181, cg00790672, cg08262220, cg02776473, cg03779878, cg22226775, cg03082523, cg00706913, cg14169886, cg03527274, cg15391425, cg12660813, cg06824308" CLIP2,ENSG00000106665,0.0033,0.0055,0.27,0.3,NA,cg21794265 HSP90AB3P,ENSG00000183199,0.0033,0.0054,0.049,0.067,NA,cg17127329 PSD3,ENSG00000156011,0.0036,0.0059,0.039,0.055,NA,cg09594160 MTHFD1,ENSG00000100714,0.0037,0.006,0.043,0.06,cg02284419,NA C1QTNF6,ENSG00000133466,0.0039,0.0063,0.13,0.15,NA,cg03156626 RBM33,ENSG00000184863,0.0039,0.0063,0.054,0.072,NA,cg21641920 IL15,ENSG00000164136,0.004,0.0064,0.063,0.082,NA,cg11418177 LYZ,ENSG00000090382,0.0041,0.0065,0.043,0.059,NA,cg16327885 LNX1,ENSG00000072201,0.0042,0.0067,0.17,0.2,NA,"cg14724298, cg06769820" BEGAIN,ENSG00000183092,0.0043,0.0068,0.052,0.07,cg03515464,NA FXR1,ENSG00000114416,0.0044,0.007,0.049,0.066,NA,cg14282096 SLC38A9,ENSG00000177058,0.0044,0.007,1,1,NA,cg09637885 TMEM131,ENSG00000075568,0.0044,0.0069,0.59,0.63,NA,cg12081267 TNNI1,ENSG00000159173,0.0044,0.0069,0.036,0.052,NA,cg26196671 MST1R,ENSG00000164078,0.0045,0.0071,1,1,NA,"cg01917209, cg18292904" DLL1,ENSG00000198719,0.0046,0.0072,0.12,0.15,cg14347219,NA DLL1,ENSG00000275555,0.0046,0.0072,0.12,0.15,cg14347219,NA ASXL3,ENSG00000141431,0.0049,0.0075,0.048,0.065,NA,cg18729523 THRB,ENSG00000151090,0.0051,0.0078,0.035,0.051,cg01165683,NA HDAC4,ENSG00000068024,0.0053,0.008,0.036,0.051,"cg19770748, cg03585122, cg05758467, cg16299358, cg18803701, cg04869380, cg22009751",cg04272486 TNRC18,ENSG00000182095,0.0054,0.0082,0.16,0.19,"cg09022230, cg01385312",NA KYNU,ENSG00000115919,0.006,0.009,0.041,0.057,NA,cg21039462 BLOC1S5-TXNDC5,ENSG00000259040,0.0065,0.0095,0.18,0.21,cg26301167,NA AKNA,ENSG00000106948,0.0066,0.0097,0.11,0.14,"cg04740744, cg15499265",NA RPS3,ENSG00000149273,0.0068,0.0099,0.065,0.085,NA,cg11643263 CEACAM7,ENSG00000280501,0.0069,0.01,0.065,0.085,NA,cg22836826 MPP3,ENSG00000161647,0.0069,0.01,0.11,0.13,NA,cg03937021 SPATA20,ENSG00000006282,0.0071,0.01,0.064,0.084,NA,cg20067719 ZNRF2,ENSG00000180233,0.0071,0.01,0.12,0.14,NA,cg08549335 CEACAM7,ENSG00000007306,0.0072,0.01,0.052,0.07,NA,cg22836826 RPS6KA4,ENSG00000162302,0.0077,0.011,0.054,0.072,NA,cg21325214 SAMD4A,ENSG00000020577,0.0079,0.011,0.096,0.12,NA,"cg22723842, cg21554616" TRIM5,ENSG00000132256,0.0079,0.011,0.085,0.11,NA,"cg25100880, cg19248404, cg05968222" INPP5D,ENSG00000168918,0.008,0.011,0.26,0.3,NA,"cg20416013, cg05208178" INPP5D,ENSG00000281614,0.008,0.011,0.26,0.3,NA,"cg20416013, cg05208178" MIA-RAB4B,ENSG00000268975,0.008,0.011,0.044,0.061,NA,"cg24083702, cg25152942" PDIK1L,ENSG00000175087,0.0086,0.012,0.094,0.12,cg00201145,NA SHANK2,ENSG00000162105,0.0086,0.012,0.084,0.11,NA,cg09245899 PIP5KL1,ENSG00000167103,0.0087,0.012,0.12,0.14,cg15650376,NA ELFN2,ENSG00000166897,0.0088,0.012,0.043,0.059,cg00107982,NA SBF1,ENSG00000100241,0.0092,0.013,1,1,cg11867308,NA KIT,ENSG00000157404,0.0097,0.013,1,1,NA,cg23487812 GNAZ,ENSG00000128266,0.0098,0.014,0.04,0.056,NA,cg06204537 SRL,ENSG00000185739,0.0098,0.014,0.046,0.063,NA,"cg02543672, cg01472962" CCDC167,ENSG00000198937,0.0099,0.014,1,1,NA,cg02029703 ZBTB20,ENSG00000181722,0.0099,0.014,0.13,0.15,NA,cg13455291 LPIN1,ENSG00000134324,0.01,0.014,0.052,0.07,cg01210354,NA ACSL6,ENSG00000164398,0.011,0.015,0.24,0.27,NA,cg25309041 ERP27,ENSG00000139055,0.011,0.015,0.13,0.16,NA,cg01556781 AMPD3,ENSG00000133805,0.012,0.016,0.048,0.065,NA,"cg22323048, cg12758847" MOBP,ENSG00000168314,0.012,0.017,0.091,0.11,NA,"cg17816989, cg04442806" TPH2,ENSG00000139287,0.012,0.016,0.051,0.069,NA,"cg02965092, cg06017039, cg07037583" ESYT3,ENSG00000158220,0.013,0.017,1,1,NA,cg00672277 FKBP5,ENSG00000096060,0.013,0.017,0.2,0.23,"cg23416081, cg25114611",NA SERPINA1,ENSG00000277377,0.013,0.017,0.045,0.062,NA,cg10761141 ANXA4,ENSG00000196975,0.014,0.019,0.24,0.28,cg03737220,NA C20orf194,ENSG00000088854,0.014,0.019,0.19,0.21,NA,cg22129980 IGFBP4,ENSG00000141753,0.014,0.018,0.057,0.075,NA,cg19878076 P4HA2,ENSG00000072682,0.014,0.019,0.17,0.2,NA,cg01329434 TOM1L2,ENSG00000175662,0.014,0.019,0.076,0.096,NA,cg27232494 SIK3,ENSG00000160584,0.015,0.02,0.037,0.053,NA,cg01116484 ARHGEF10L,ENSG00000074964,0.016,0.021,0.23,0.26,cg26489226,NA KCTD7,ENSG00000243335,0.016,0.021,0.037,0.053,cg04010163,NA SPAG16,ENSG00000144451,0.016,0.021,0.099,0.12,NA,"cg22981344, cg25824236, cg18403833" CD226,ENSG00000150637,0.017,0.022,0.17,0.2,NA,cg12280202 ITM2C,ENSG00000135916,0.018,0.023,0.068,0.088,"cg02231590, cg14447588, cg06003912",NA KCNB1,ENSG00000158445,0.018,0.024,0.18,0.21,NA,cg11617503 PPP4R2,ENSG00000163605,0.018,0.023,0.044,0.061,cg22807516,NA IRF2BPL,ENSG00000119669,0.019,0.025,0.54,0.58,cg13493526,NA ADAMTSL3,ENSG00000156218,0.02,0.026,0.056,0.075,NA,"cg03644154, cg06851885, cg03588739, cg06428304, cg11051306" CLN3,ENSG00000188603,0.02,0.026,0.16,0.19,cg27421852,NA COTL1,ENSG00000103187,0.02,0.026,0.39,0.42,NA,cg15188631 CYP2W1,ENSG00000073067,0.02,0.026,0.15,0.17,"cg04141948, cg21077578",NA WNT11,ENSG00000085741,0.02,0.026,1,1,NA,cg17761226 CHURC1-FNTB,ENSG00000125954,0.021,0.027,0.19,0.22,"cg16645453, cg20707568",NA HIVEP3,ENSG00000127124,0.021,0.027,0.11,0.14,NA,"cg13417104, cg04464434, cg16152117, cg14663208, cg14290913" HSD11B2,ENSG00000176387,0.021,0.026,0.23,0.26,cg01443318,NA NFIX,ENSG00000008441,0.021,0.027,0.038,0.053,NA,cg01617040 RPL13AP7,ENSG00000213885,0.021,0.027,0.14,0.17,NA,cg05198244 SEMA6D,ENSG00000137872,0.021,0.026,0.18,0.21,NA,"cg18830699, cg15976080, cg10477878, cg02930552" STK39,ENSG00000198648,0.021,0.026,1,1,NA,cg17252489 PRDM11,ENSG00000019485,0.022,0.028,0.036,0.051,cg17788708,NA TLL2,ENSG00000095587,0.022,0.028,0.046,0.063,NA,cg04401753 TACC1,ENSG00000147526,0.023,0.029,0.87,0.91,NA,cg19753650 ABCC9,ENSG00000069431,0.024,0.03,0.12,0.15,NA,cg09185990 ANKRD13D,ENSG00000172932,0.024,0.03,0.12,0.14,cg20968200,NA MYH9,ENSG00000100345,0.024,0.03,0.44,0.47,NA,cg08800893 OTUD7A,ENSG00000169918,0.024,0.03,0.45,0.49,NA,cg08955294 NEGR1,ENSG00000172260,0.025,0.032,0.3,0.33,NA,"cg12073709, cg05928873" SH3D19,ENSG00000109686,0.025,0.031,1,1,NA,cg15143723 CCDC7,ENSG00000216937,0.026,0.032,0.073,0.093,NA,cg17866723 COL7A1,ENSG00000114270,0.026,0.033,0.058,0.076,NA,cg17415010 PFDN4,ENSG00000101132,0.026,0.032,0.087,0.11,NA,cg14816904 RIMBP2,ENSG00000060709,0.026,0.032,0.061,0.08,NA,"cg07988206, cg18538532, cg17192862, cg23373401, cg15001406, cg16086237, cg15026456, cg15858166, cg07703756" IFIH1,ENSG00000115267,0.028,0.034,0.37,0.4,NA,cg24105617 PPFIBP2,ENSG00000166387,0.029,0.036,0.12,0.14,cg05137777,cg08404054 CACNA2D4,ENSG00000151062,0.03,0.037,0.063,0.082,NA,"cg02435785, cg13551505, cg23330270, cg25086337" CACNA2D4,ENSG00000284953,0.03,0.037,0.063,0.082,NA,"cg02435785, cg13551505, cg23330270, cg25086337" CNTNAP2,ENSG00000278728,0.03,0.037,0.056,0.074,NA,"cg06880494, cg03707604, cg01067813, cg17493489, cg19139509, cg16762439, cg23548616, cg16341266, cg18804920" XAF1,ENSG00000132530,0.031,0.038,0.051,0.068,NA,cg11803424 RHBDL1,ENSG00000103269,0.032,0.039,0.04,0.056,cg10060399,NA SNRPN,ENSG00000128739,0.032,0.04,0.15,0.18,NA,"cg04689398, cg25682399" OR5AS1,ENSG00000181785,0.033,0.041,0.22,0.25,NA,cg17060964 ACOT7,ENSG00000097021,0.034,0.041,0.061,0.08,NA,cg10770046 KAZALD1,ENSG00000107821,0.035,0.043,0.24,0.28,NA,cg17333042 SSUH2,ENSG00000125046,0.035,0.043,1,1,NA,"cg09248934, cg12026594" AGAP1,ENSG00000157985,0.037,0.045,0.053,0.071,cg08348422,cg13250592 CCDC144A,ENSG00000170160,0.037,0.045,0.038,0.054,NA,cg05530484 SPOCK2,ENSG00000107742,0.037,0.045,0.2,0.23,NA,cg12816486 ZNF382,ENSG00000161298,0.038,0.046,0.13,0.16,NA,cg05015359 DPF3,ENSG00000205683,0.039,0.048,0.31,0.35,NA,cg09218076 SGSM1,ENSG00000167037,0.039,0.047,0.45,0.48,NA,"cg13416895, cg07456172" PLCXD3,ENSG00000182836,0.04,0.048,0.66,0.69,NA,cg05638200 SVOPL,ENSG00000157703,0.042,0.05,0.14,0.16,NA,cg13195239