Table S1  KEGG pathway analysis of DEGs in TBSI vs CTRL.,,,,,
ID,Description,Gene,enrich_factor,pvalue,gene_number
rno04080,Neuroactive ligand-receptor interaction,"ENSRNOG00000002360|Gabrg1, ENSRNOG00000053402|Gabrq, ENSRNOG00000005723|Grin3a, ENSRNOG00000016654|Galr1, ENSRNOG00000004632|Pmch, ENSRNOG00000012789|Mlnr, ENSRNOG00000018892|Hcrt, ENSRNOG00000014427|Chrnb4, ENSRNOG00000013171|Grm2, ENSRNOG00000012703|Crh, ENSRNOG00000004451|Mc3r, ENSRNOG00000008431|Gabbr2, ENSRNOG00000002549|Htr5b, ENSRNOG00000020778|Chrnb2, ENSRNOG00000008992|Grik3, ENSRNOG00000002349|Gabra2, ENSRNOG00000008766|Grin2b, ENSRNOG00000010997|Ednrb, ENSRNOG00000046834|C3, ENSRNOG00000013829|Chrna3, ENSRNOG00000045816|Gria1, ENSRNOG00000006397|Chrm5, ENSRNOG00000003569|Gabra6, ENSRNOG00000030318|Gpr83, ENSRNOG00000012686|Pomc, ENSRNOG00000021547|Pgr15l, ENSRNOG00000012448|Chrnb3, ENSRNOG00000018191|Oprm1, ENSRNOG00000000873|Brs3, ENSRNOG00000011335|Gpr50, ENSRNOG00000019134|Htr4, ENSRNOG00000000897|Rxfp2, ENSRNOG00000043124|Cckar, ENSRNOG00000002327|Gabrb1, ENSRNOG00000021229|Avp, ENSRNOG00000023126|Rxfp3, ENSRNOG00000010053|Calcr, ENSRNOG00000057557|Prlr, ENSRNOG00000017002|Adrb1, ENSRNOG00000016429|Grm5",0.1149,7.36E-16,40
rno05033,Nicotine addiction,"ENSRNOG00000002360|Gabrg1, ENSRNOG00000053402|Gabrq, ENSRNOG00000005723|Grin3a, ENSRNOG00000020778|Chrnb2, ENSRNOG00000002349|Gabra2, ENSRNOG00000008766|Grin2b, ENSRNOG00000045816|Gria1, ENSRNOG00000003569|Gabra6, ENSRNOG00000002327|Gabrb1",0.225,6.29E-07,9
rno05032,Morphine addiction,"ENSRNOG00000002360|Gabrg1, ENSRNOG00000053402|Gabrq, ENSRNOG00000015541|Gnb3, ENSRNOG00000001658|Kcnj6, ENSRNOG00000030404|Arrb1, ENSRNOG00000008431|Gabbr2, ENSRNOG00000054212|Pde1a, ENSRNOG00000002349|Gabra2, ENSRNOG00000042536|Pde4d, ENSRNOG00000003569|Gabra6, ENSRNOG00000018191|Oprm1, ENSRNOG00000013436|Pde7b, ENSRNOG00000002327|Gabrb1",0.1368,9.30E-07,13
rno04360,Axon guidance,"ENSRNOG00000031801|Ephb3, ENSRNOG00000007377|Slit3, ENSRNOG00000004676|Pak3, ENSRNOG00000016289|Bmpr1b, ENSRNOG00000007970|Plxnc1, ENSRNOG00000004603|Srgap1, ENSRNOG00000034177|Efna5, ENSRNOG00000027233|Trpc5, ENSRNOG00000006877|Efnb1, ENSRNOG00000013072|Plxna4, ENSRNOG00000033099|Dcc, ENSRNOG00000003947|Ntn1, ENSRNOG00000007030|Epha7, ENSRNOG00000013166|Wnt4, ENSRNOG00000017525|Epha1, ENSRNOG00000011133|Trpc4",0.0889,1.70E-05,16
rno04727,GABAergic synapse,"ENSRNOG00000002360|Gabrg1, ENSRNOG00000053402|Gabrq, ENSRNOG00000015541|Gnb3, ENSRNOG00000001658|Kcnj6, ENSRNOG00000005697|Slc6a11, ENSRNOG00000008431|Gabbr2, ENSRNOG00000002349|Gabra2, ENSRNOG00000003569|Gabra6, ENSRNOG00000002327|Gabrb1",0.0989,0.000571592,9
rno04724,Glutamatergic synapse,"ENSRNOG00000015541|Gnb3, ENSRNOG00000005723|Grin3a, ENSRNOG00000013171|Grm2, ENSRNOG00000008992|Grik3, ENSRNOG00000008766|Grin2b, ENSRNOG00000045816|Gria1, ENSRNOG00000016163|Slc1a3, ENSRNOG00000061450|Homer2, ENSRNOG00000016429|Grm5",0.0783,0.002998576,9
rno04723,Retrograde endocannabinoid signaling,"ENSRNOG00000002360|Gabrg1, ENSRNOG00000053402|Gabrq, ENSRNOG00000015541|Gnb3, ENSRNOG00000001658|Kcnj6, ENSRNOG00000002349|Gabra2, ENSRNOG00000045816|Gria1, ENSRNOG00000003569|Gabra6, ENSRNOG00000014508|Mgll, ENSRNOG00000002327|Gabrb1, ENSRNOG00000016429|Grm5",0.0645,0.007134261,10
rno05030,Cocaine addiction,"ENSRNOG00000017302|Slc6a3, ENSRNOG00000005723|Grin3a, ENSRNOG00000013171|Grm2, ENSRNOG00000008766|Grin2b, ENSRNOG00000021685|Cdk5r1",0.1042,0.007862811,5
rno01523,Antifolate resistance,"ENSRNOG00000007041|Abcg2, ENSRNOG00000046727|Abcc2, ENSRNOG00000037225|Tyms, ENSRNOG00000019902|Folr1",0.129,0.008091979,4
rno04976,Bile secretion,"ENSRNOG00000007041|Abcg2, ENSRNOG00000031249|Slco1a2, ENSRNOG00000046727|Abcc2, ENSRNOG00000003134|Slc4a4, ENSRNOG00000010378|Slc4a5, ENSRNOG00000011648|Aqp1",0.0833,0.010867176,6
rno00564,Glycerophospholipid metabolism,"ENSRNOG00000056457|Gpd1, ENSRNOG00000008116|Plpp3, ENSRNOG00000045743|Etnppl, ENSRNOG00000021265|Cds2, ENSRNOG00000010065|Dgkh, ENSRNOG00000016838|Pla2g5, ENSRNOG00000025121|Pla2g3",0.0722,0.013042993,7
rno04150,mTOR signaling pathway,"ENSRNOG00000011815|Sgk1, ENSRNOG00000011341|Rictor, ENSRNOG00000006136|Pdpk1, ENSRNOG00000014859|Rnf152, ENSRNOG00000051905|Wnt2, ENSRNOG00000052510|Wnt10a, ENSRNOG00000004328|Deptor, ENSRNOG00000007706|Prkaa2, ENSRNOG00000013166|Wnt4",0.0581,0.019726615,9
rno04928,"Parathyroid hormone synthesis, secretion and action","ENSRNOG00000010947|Mmp14, ENSRNOG00000004332|Egfr, ENSRNOG00000030404|Arrb1, ENSRNOG00000054420|Vdr, ENSRNOG00000001092|Kl, ENSRNOG00000042536|Pde4d, ENSRNOG00000002265|Casr",0.066,0.020373397,7
rno00592,alpha-Linolenic acid metabolism,"ENSRNOG00000020440|Fads2, ENSRNOG00000016838|Pla2g5, ENSRNOG00000025121|Pla2g3",0.1304,0.0209769,3
rno04340,Hedgehog signaling pathway,"ENSRNOG00000030404|Arrb1, ENSRNOG00000016620|Csnk1g1, ENSRNOG00000014395|Gli3, ENSRNOG00000057710|Ccnd2",0.093,0.024939485,4
rno04020,Calcium signaling pathway,"ENSRNOG00000004332|Egfr, ENSRNOG00000012789|Mlnr, ENSRNOG00000002549|Htr5b, ENSRNOG00000054212|Pde1a, ENSRNOG00000010997|Ednrb, ENSRNOG00000006397|Chrm5, ENSRNOG00000019134|Htr4, ENSRNOG00000043124|Cckar, ENSRNOG00000017002|Adrb1, ENSRNOG00000016429|Grm5",0.0529,0.025664977,10
rno04672,Intestinal immune network for IgA production,"ENSRNOG00000007664|Tnfrsf13c, ENSRNOG00000014464|Tnfsf13b, ENSRNOG00000033215|RT1-Db1, ENSRNOG00000000451|RT1-Ba",0.0909,0.026891216,4
rno05150,Staphylococcus aureus infection,"ENSRNOG00000012749|C1qb, ENSRNOG00000024382|Fcgr3a, ENSRNOG00000046834|C3, ENSRNOG00000033215|RT1-Db1, ENSRNOG00000000451|RT1-Ba",0.0758,0.028241096,5
rno04640,Hematopoietic cell lineage,"ENSRNOG00000020699|Cd37, ENSRNOG00000013615|Dntt, ENSRNOG00000036674|Cd7, ENSRNOG00000033215|RT1-Db1, ENSRNOG00000000451|RT1-Ba, ENSRNOG00000001005|Fcer2",0.0659,0.03098897,6
rno05231,Choline metabolism in cancer,"ENSRNOG00000008116|Plpp3, ENSRNOG00000004332|Egfr, ENSRNOG00000006136|Pdpk1, ENSRNOG00000022946|Slc22a3, ENSRNOG00000010065|Dgkh, ENSRNOG00000010695|Pdgfc",0.0625,0.038792387,6
rno04924,Renin secretion,"ENSRNOG00000054212|Pde1a, ENSRNOG00000005985|Kcnma1, ENSRNOG00000011648|Aqp1, ENSRNOG00000002361|Prkg2, ENSRNOG00000017002|Adrb1",0.0694,0.039077998,5
rno04014,Ras signaling pathway,"ENSRNOG00000015541|Gnb3, ENSRNOG00000004676|Pak3, ENSRNOG00000004332|Egfr, ENSRNOG00000005854|Angpt1, ENSRNOG00000008766|Grin2b, ENSRNOG00000034177|Efna5, ENSRNOG00000003587|Vegfd, ENSRNOG00000005404|Rasgrp1, ENSRNOG00000016838|Pla2g5, ENSRNOG00000010695|Pdgfc, ENSRNOG00000025121|Pla2g3",0.0474,0.039725383,11
rno04713,Circadian entrainment,"ENSRNOG00000015541|Gnb3, ENSRNOG00000001658|Kcnj6, ENSRNOG00000003348|Rasd1, ENSRNOG00000008766|Grin2b, ENSRNOG00000045816|Gria1, ENSRNOG00000002361|Prkg2",0.0612,0.042234351,6
rno04916,Melanogenesis,"ENSRNOG00000008671|AABR07019383, ENSRNOG00000051905|Wnt2, ENSRNOG00000010997|Ednrb, ENSRNOG00000052510|Wnt10a, ENSRNOG00000012686|Pomc, ENSRNOG00000013166|Wnt4",0.0612,0.042234351,6
rno04068,FoxO signaling pathway,"ENSRNOG00000011815|Sgk1, ENSRNOG00000004332|Egfr, ENSRNOG00000013397|Foxo1, ENSRNOG00000006136|Pdpk1, ENSRNOG00000007706|Prkaa2, ENSRNOG00000061450|Homer2, ENSRNOG00000057710|Ccnd2",0.0556,0.04596675,7
rno04972,Pancreatic secretion,"ENSRNOG00000005985|Kcnma1, ENSRNOG00000003134|Slc4a4, ENSRNOG00000043124|Cckar, ENSRNOG00000016838|Pla2g5, ENSRNOG00000012176|Rab27b, ENSRNOG00000025121|Pla2g3",0.0594,0.047748176,6