Nuclear Volumes (µm3),,,,,,,,,,,,, ,,,,,,,,Fgf8CreER;Tbx2F/F,,,,, Control-I,Control-O,Atoh1Cre;Tbx2F/F-I,Atoh1Cre;Tbx2F/F- O,Gfi1Cre;Tbx2F/F- I,Gfi1Cre;Tbx2F/F- O,Atoh1cre;Tbx2F/F;Insm1F/F- I,Atoh1cre;Tbx2F/F;Insm1F/F- O,TAM@P0- I,TAM@P0- O,TAM@P7- I,TAM@P7- O,TAM@P9- I,TAM@P9- O 179.43,111.85,127.5,122.08,118.07,113.34,147.74,129.75,134.38,128.06,153.77,144.41,152.61,140.1 240.24,120.69,142.66,140.9,128.01,112.44,149.76,110.06,150.36,130.29,164.92,135.12,139.67,131.07 231.42,111.59,135.31,129.24,112.63,122.36,158.81,136.26,149.94,140.81,167.4,129.84,131.34,112.47 221.86,106.08,140.68,120.5,131.7,130.48,155.59,113.57,142.46,123.24,178.38,124.61,135.04,121.79 249.76,86.93,127.14,103.6,140.16,109.86,165.05,107.53,160.51,124.83,180.88,148.75,139.14,124.35 260.6,91.81,131.11,114.84,122.46,112.82,143.67,107.52,156.1,143.57,160.63,155.51,134.4,145.36 265.26,127.59,153.71,133.98,139.37,130.27,118.81,120.04,131.18,139.98,162.13,142.55,,134.37 266.55,129.06,134.88,144.27,130.51,122.26,138.18,143.56,138.67,145.73,157.09,147.55,,128.35 229.18,151.11,108.34,136.49,105.37,112.52,134.24,128.2,,143.64,128.91,178.67,,162.11 260.1,107.66,149.34,103.22,,118.17,128.9,128.49,,143.49,141.22,152.57,,139.95 191.71,86.08,138.88,111.81,,121.11,125.6,140.2,,152.18,158.05,163.71,,159.65 199.83,111.99,132.03,143.78,,120.91,118.75,145.23,,146.02,153.53,167.21,,145.07 155.09,104.49,150.76,107.51,,128.37,113.7,128.71,,156.61,144.31,169.52,,136.39 220.84,154.18,137.92,120.99,,133.32,124.72,140.28,,148.62,136.63,180.26,,157.42 214.97,106.56,130.34,135.4,,117.15,122.35,142.29,,157.5,149.42,176.92,,142.95 183.14,123.11,119.37,121.76,,123,122.78,150.73,,142.82,121.72,171.66,,159 244.18,105.01,,131.09,,127.67,129.45,137.03,,155.29,135.52,169.28,,146.5 188.23,123.67,,132.96,,127.21,160.05,151.25,,159.48,150.42,168.97,,154.92 206.45,147.87,,131.08,,132.97,141.9,135.17,,139.03,147.64,165.56,, 247.99,124.4,,121.25,,136.84,177.64,144.27,,135.07,,164.16,, 183.94,125.92,,124.62,,136.62,128.17,158.54,,131.64,,171.72,, 225.74,131.96,,126.94,,125.07,181.43,120.78,,144.23,,155.55,, 161.24,152.39,,125.54,,106.93,135.72,148.2,,119.54,,155.19,, 237.14,128.23,,121.38,,116.86,122.97,130.94,,133.6,,153.92,, 216.27,123.77,,111.5,,129.67,144.77,117.1,,156.45,,140.76,, 244.99,142.66,,109.79,,104.81,159.02,143.5,,113.16,,167.09,, 234.08,127.68,,103.93,,113.46,152.49,124.18,,123.27,,156.52,, 239.4,119.74,,110.41,,115.82,,106.45,,153.47,,140.73,, 248.73,144.25,,110.62,,109.28,,121.76,,138.11,,117.72,, 232.64,143.49,,124.03,,102.43,,111.21,,152.25,,134.56,, 224.78,127.02,,140.42,,113.86,,127.8,,146.6,,124.27,, 204.33,138.58,,114.55,,106.42,,124.34,,136.38,,130.87,, 238.9,143.42,,123.16,,101.41,,128.23,,,,139.17,, 226.56,127.45,,104.8,,105.39,,116.89,,,,114.84,, 242.51,128.84,,132.95,,,,113.69,,,,118.98,, 250.65,141.84,,122.01,,,,112.06,,,,114.44,, 250.39,137.44,,103.04,,,,130.54,,,,136.88,, 232.97,164.3,,102.55,,,,115.7,,,,135.89,, 226.82,126.98,,127.75,,,,123.54,,,,130.98,, 225.34,113.1,,109.62,,,,139.38,,,,118.79,, 229.22,127.9,,104.17,,,,114.71,,,,129.21,, 210.46,139.97,,122.27,,,,135.1,,,,122.4,, 211.93,132.17,,141.99,,,,152.63,,,,121.53,, 201.82,152.01,,103.47,,,,125.87,,,,122,, 223.49,103.56,,143.75,,,,136.32,,,,122.18,, 216.53,161.1,,114.94,,,,124.05,,,,133.16,, 216.88,122.6,,128.58,,,,143.64,,,,127.8,, 217.79,109.6,,150.67,,,,134.73,,,,135.39,, 232.33,137.67,,125.3,,,,133.61,,,,132.82,, 225.47,127.8,,129.25,,,,137.8,,,,138.03,, 223.28,145.68,,150.89,,,,136.82,,,,144.49,, 230.73,123.85,,124.8,,,,140.91,,,,139.01,, 183.28,126.22,,149.64,,,,133.73,,,,138.74,, 231.87,97.17,,128.98,,,,131.43,,,,149.45,, 249.99,125.55,,119.13,,,,128.4,,,,144.09,, 273.02,93.85,,114.79,,,,143.93,,,,149.43,, 265.52,121.56,,132.55,,,,147.08,,,,160.82,, 268.8,93.02,,104.24,,,,130.7,,,,141.85,, 261.09,85.46,,132.05,,,,138.53,,,,161.42,, 274.21,117.36,,114.15,,,,130.26,,,,145.07,, 249.87,110.46,,112.5,,,,139.53,,,,175.79,, 260.51,125.18,,,,,,130.9,,,,162.99,, 245.24,88.54,,,,,,118.57,,,,169.29,, 272.53,110.19,,,,,,112.88,,,,145.5,, 269.05,134.12,,,,,,140.28,,,,162.27,, 261.61,142.77,,,,,,136.46,,,,175.47,, 238.98,133.33,,,,,,120.2,,,,155.23,, 240.64,128.85,,,,,,114.21,,,,179.15,, 234.14,115.64,,,,,,119.13,,,,158.96,, 228.6,128.2,,,,,,123.1,,,,154.51,, 215.84,126.71,,,,,,117.37,,,,135.47,, 238.04,119.37,,,,,,120.65,,,,176.87,, 237.52,115,,,,,,117.96,,,,146.53,, 276.55,151.99,,,,,,120.56,,,,135.46,, 229.5,127.41,,,,,,120.98,,,,151.64,, 248.38,150.82,,,,,,119.56,,,,124.32,, 241.86,127.71,,,,,,136.52,,,,,, 260.09,139.95,,,,,,126.62,,,,,, 272.06,128.24,,,,,,119.67,,,,,, 224.67,121.62,,,,,,131.26,,,,,, 285.73,152.49,,,,,,140.49,,,,,, 254.03,122.19,,,,,,125.36,,,,,, 253.83,141.22,,,,,,113.76,,,,,, 234.33,123.76,,,,,,133.01,,,,,, 217.96,122.81,,,,,,124.03,,,,,, 221.8,118.98,,,,,,132.61,,,,,, 249.92,123.57,,,,,,120.06,,,,,, 218.26,127.88,,,,,,126.46,,,,,, 238.85,134.2,,,,,,112.46,,,,,, 252.87,118.99,,,,,,114,,,,,, 207.48,133.93,,,,,,141.23,,,,,, 219.69,131.63,,,,,,145.37,,,,,, 232.82,134.5,,,,,,158.66,,,,,, 223.68,119.03,,,,,,134.84,,,,,, 243.14,123.9,,,,,,139.2,,,,,, 236.96,118.76,,,,,,128.47,,,,,, 231.15,121.92,,,,,,134.74,,,,,, 226.95,112.24,,,,,,138.88,,,,,, 205.74,118.76,,,,,,132.3,,,,,, 230.67,98.38,,,,,,120.92,,,,,, 214.18,114.61,,,,,,125.15,,,,,, 197.48,121.43,,,,,,145.15,,,,,, 221.74,125.69,,,,,,130.92,,,,,, 237.04,118.47,,,,,,152.23,,,,,, 210.7,123.02,,,,,,163.7,,,,,, 230.06,121.71,,,,,,115.49,,,,,, 207.84,127.43,,,,,,123.96,,,,,, 229.96,117.04,,,,,,116.17,,,,,, 238.1,120.19,,,,,,140.86,,,,,, 203.33,142.08,,,,,,164.16,,,,,, 229.13,127.82,,,,,,127.64,,,,,, 272.15,146.44,,,,,,154.04,,,,,, 222.92,125.24,,,,,,125.52,,,,,, 254.64,153.76,,,,,,111.05,,,,,, 240.85,155.57,,,,,,140.2,,,,,, 235.43,130.37,,,,,,145.93,,,,,, 210.23,136.27,,,,,,127.1,,,,,, 220.07,139.71,,,,,,124.02,,,,,, 241.91,155.12,,,,,,129.66,,,,,, 244.43,139.57,,,,,,144.08,,,,,, 241.34,147.31,,,,,,133.95,,,,,, 241.76,150.2,,,,,,148.53,,,,,, 241.79,145.85,,,,,,127.28,,,,,, 228.43,155.22,,,,,,145.92,,,,,, ,140.07,,,,,,148.66,,,,,, ,145.5,,,,,,144.59,,,,,, ,141.87,,,,,,128.76,,,,,, ,145.38,,,,,,163.45,,,,,, ,144.23,,,,,,147.7,,,,,, ,131.54,,,,,,134.94,,,,,, ,130.1,,,,,,159.18,,,,,, ,127.07,,,,,,142.72,,,,,, ,138.42,,,,,,158.1,,,,,, ,131.64,,,,,,135.86,,,,,, ,118.31,,,,,,144.68,,,,,, ,110.49,,,,,,160.8,,,,,, ,121.36,,,,,,133.23,,,,,, ,123.22,,,,,,144.04,,,,,, ,114.13,,,,,,129.31,,,,,, ,123.15,,,,,,133.43,,,,,, ,114.8,,,,,,144.77,,,,,, ,119.29,,,,,,,,,,,, ,116.74,,,,,,,,,,,, ,132.98,,,,,,,,,,,, ,140.72,,,,,,,,,,,, ,123.3,,,,,,,,,,,, ,133.14,,,,,,,,,,,, ,128.02,,,,,,,,,,,, ,137.49,,,,,,,,,,,, ,131.44,,,,,,,,,,,, ,136.71,,,,,,,,,,,, ,130.04,,,,,,,,,,,, ,144.95,,,,,,,,,,,, ,140.55,,,,,,,,,,,, ,145.32,,,,,,,,,,,, ,138.41,,,,,,,,,,,, ,151.82,,,,,,,,,,,, ,160.68,,,,,,,,,,,, ,135.85,,,,,,,,,,,, ,156.28,,,,,,,,,,,, ,156.87,,,,,,,,,,,, ,143.99,,,,,,,,,,,, ,134.53,,,,,,,,,,,, ,157.92,,,,,,,,,,,, ,137.4,,,,,,,,,,,, ,143.74,,,,,,,,,,,, ,141.65,,,,,,,,,,,, ,144.34,,,,,,,,,,,, ,142.54,,,,,,,,,,,, ,148.15,,,,,,,,,,,, ,141.57,,,,,,,,,,,, ,134.32,,,,,,,,,,,, ,133.67,,,,,,,,,,,, ,137.82,,,,,,,,,,,, ,140.06,,,,,,,,,,,, ,126.55,,,,,,,,,,,, ,134.15,,,,,,,,,,,, ,114.14,,,,,,,,,,,, ,118.39,,,,,,,,,,,, ,110.92,,,,,,,,,,,, ,104.05,,,,,,,,,,,, ,121.56,,,,,,,,,,,, ,113.9,,,,,,,,,,,, ,113.79,,,,,,,,,,,, ,120.55,,,,,,,,,,,, ,117.45,,,,,,,,,,,, ,122.67,,,,,,,,,,,, ,125.83,,,,,,,,,,,, ,123.42,,,,,,,,,,,, ,125.17,,,,,,,,,,,, ,120.93,,,,,,,,,,,, ,137.82,,,,,,,,,,,, ,116.25,,,,,,,,,,,, ,117.25,,,,,,,,,,,, ,133.9,,,,,,,,,,,, ,121.37,,,,,,,,,,,, ,107.54,,,,,,,,,,,, ,128.94,,,,,,,,,,,, ,121.66,,,,,,,,,,,, ,122.45,,,,,,,,,,,, ,111.58,,,,,,,,,,,, ,121.65,,,,,,,,,,,, ,123.37,,,,,,,,,,,, ,126.43,,,,,,,,,,,, ,106.09,,,,,,,,,,,, ,107.41,,,,,,,,,,,, ,121.76,,,,,,,,,,,, ,106.4,,,,,,,,,,,, ,117.91,,,,,,,,,,,, ,110.67,,,,,,,,,,,, ,118.1,,,,,,,,,,,, ,114.97,,,,,,,,,,,, ,120.65,,,,,,,,,,,, ,117.52,,,,,,,,,,,, ,125.3,,,,,,,,,,,, ,145.4,,,,,,,,,,,, ,105.96,,,,,,,,,,,, ,116.64,,,,,,,,,,,, ,112.7,,,,,,,,,,,, ,159.63,,,,,,,,,,,, ,107.5,,,,,,,,,,,, ,116.27,,,,,,,,,,,, ,131.43,,,,,,,,,,,, ,158.53,,,,,,,,,,,, ,131.61,,,,,,,,,,,, ,157.41,,,,,,,,,,,, ,117.93,,,,,,,,,,,, ,117.74,,,,,,,,,,,, ,154.34,,,,,,,,,,,, ,154.01,,,,,,,,,,,, ,136.76,,,,,,,,,,,, ,160.05,,,,,,,,,,,, ,118.42,,,,,,,,,,,, ,135.68,,,,,,,,,,,, ,154.3,,,,,,,,,,,, ,144.55,,,,,,,,,,,, ,134.97,,,,,,,,,,,, ,135.76,,,,,,,,,,,, ,114.67,,,,,,,,,,,, ,126.85,,,,,,,,,,,, ,124.16,,,,,,,,,,,, ,125.59,,,,,,,,,,,, ,121.11,,,,,,,,,,,, ,133.25,,,,,,,,,,,, ,123.4,,,,,,,,,,,, ,143.54,,,,,,,,,,,, ,163.87,,,,,,,,,,,, ,182.5,,,,,,,,,,,, ,186.76,,,,,,,,,,,, ,173.35,,,,,,,,,,,, ,129.99,,,,,,,,,,,, ,155.93,,,,,,,,,,,, ,153.98,,,,,,,,,,,, ,147.87,,,,,,,,,,,, ,129.62,,,,,,,,,,,, ,128.6,,,,,,,,,,,, ,121.72,,,,,,,,,,,, ,135.49,,,,,,,,,,,, ,138.46,,,,,,,,,,,, ,141.98,,,,,,,,,,,, ,136.55,,,,,,,,,,,, ,141.42,,,,,,,,,,,, ,137.08,,,,,,,,,,,, ,134.62,,,,,,,,,,,, ,147.8,,,,,,,,,,,, ,144.2,,,,,,,,,,,, ,146.17,,,,,,,,,,,, ,141.77,,,,,,,,,,,, ,154.01,,,,,,,,,,,, ,164.26,,,,,,,,,,,, ,148.16,,,,,,,,,,,, ,144.15,,,,,,,,,,,, ,158.54,,,,,,,,,,,, ,162.04,,,,,,,,,,,, ,144.85,,,,,,,,,,,, ,135.67,,,,,,,,,,,, ,165.44,,,,,,,,,,,, ,141.1,,,,,,,,,,,, ,137.88,,,,,,,,,,,, ,120.39,,,,,,,,,,,, ,128.46,,,,,,,,,,,, ,131.18,,,,,,,,,,,, ,168.97,,,,,,,,,,,, ,125.19,,,,,,,,,,,, ,112.21,,,,,,,,,,,, ,122.53,,,,,,,,,,,, ,152.46,,,,,,,,,,,, ,111.69,,,,,,,,,,,, ,137.91,,,,,,,,,,,, ,122.77,,,,,,,,,,,, ,140.73,,,,,,,,,,,, ,120.16,,,,,,,,,,,, ,114.25,,,,,,,,,,,, ,132,,,,,,,,,,,, ,132.43,,,,,,,,,,,, ,128.67,,,,,,,,,,,, ,129.41,,,,,,,,,,,, ,125.79,,,,,,,,,,,, ,147.34,,,,,,,,,,,, ,130.36,,,,,,,,,,,, ,137.66,,,,,,,,,,,, ,134.75,,,,,,,,,,,, ,123.36,,,,,,,,,,,, ,133,,,,,,,,,,,, ,148.1,,,,,,,,,,,, ,139.05,,,,,,,,,,,, ,139.67,,,,,,,,,,,, ,132.35,,,,,,,,,,,, ,141.05,,,,,,,,,,,, ,143.79,,,,,,,,,,,, ,151.75,,,,,,,,,,,, ,154.27,,,,,,,,,,,, ,133.67,,,,,,,,,,,, ,132.68,,,,,,,,,,,, ,146.16,,,,,,,,,,,, ,147.89,,,,,,,,,,,, ,145.17,,,,,,,,,,,, ,145.24,,,,,,,,,,,, ,129.9,,,,,,,,,,,, ,136.66,,,,,,,,,,,, ,149.54,,,,,,,,,,,, ,134.48,,,,,,,,,,,, ,127.77,,,,,,,,,,,, ,139.85,,,,,,,,,,,, ,145.26,,,,,,,,,,,, ,122.88,,,,,,,,,,,, ,141.06,,,,,,,,,,,, ,143.72,,,,,,,,,,,, ,142.77,,,,,,,,,,,, ,125.71,,,,,,,,,,,, ,111.59,,,,,,,,,,,, ,114.34,,,,,,,,,,,, ,127.79,,,,,,,,,,,, ,118.88,,,,,,,,,,,, ,118.28,,,,,,,,,,,, ,127.5,,,,,,,,,,,, ,122.12,,,,,,,,,,,, ,134.93,,,,,,,,,,,, ,136.31,,,,,,,,,,,, ,119.72,,,,,,,,,,,, ,134.16,,,,,,,,,,,, ,121.59,,,,,,,,,,,, ,137.89,,,,,,,,,,,, ,137.12,,,,,,,,,,,, ,129.4,,,,,,,,,,,, ,124.08,,,,,,,,,,,, ,135.07,,,,,,,,,,,, ,120.36,,,,,,,,,,,, ,137.02,,,,,,,,,,,, ,136.14,,,,,,,,,,,, ,131.69,,,,,,,,,,,, ,132.69,,,,,,,,,,,, ,131.88,,,,,,,,,,,, ,126.12,,,,,,,,,,,, ,121.32,,,,,,,,,,,, ,144.54,,,,,,,,,,,, ,134.64,,,,,,,,,,,, ,161.1,,,,,,,,,,,, ,127.98,,,,,,,,,,,, ,121.34,,,,,,,,,,,, ,168.84,,,,,,,,,,,, ,122.04,,,,,,,,,,,, ,127.17,,,,,,,,,,,, ,132.96,,,,,,,,,,,, ,175.35,,,,,,,,,,,, ,130.05,,,,,,,,,,,, ,175.6,,,,,,,,,,,, ,124.4,,,,,,,,,,,, ,138.3,,,,,,,,,,,, ,130.71,,,,,,,,,,,, ,165.05,,,,,,,,,,,, ,133.41,,,,,,,,,,,, ,161.01,,,,,,,,,,,, ,128.89,,,,,,,,,,,, ,144.62,,,,,,,,,,,, ,132.5,,,,,,,,,,,, ,135.96,,,,,,,,,,,, ,135.74,,,,,,,,,,,, ,138.2,,,,,,,,,,,, ,127.95,,,,,,,,,,,, ,142.38,,,,,,,,,,,, ,159.13,,,,,,,,,,,, ,149.46,,,,,,,,,,,, ,122.67,,,,,,,,,,,, ,150.65,,,,,,,,,,,, ,143.29,,,,,,,,,,,, ,163.64,,,,,,,,,,,, ,161.8,,,,,,,,,,,, ,131.48,,,,,,,,,,,, ,158.27,,,,,,,,,,,, ,153.55,,,,,,,,,,,, ,137.8,,,,,,,,,,,, ,138.09,,,,,,,,,,,, ,138.21,,,,,,,,,,,, ,118.21,,,,,,,,,,,, ,127.17,,,,,,,,,,,, ,119.73,,,,,,,,,,,, ,140.46,,,,,,,,,,,, ,131.8,,,,,,,,,,,, ,120.88,,,,,,,,,,,, ,120.18,,,,,,,,,,,, ,112.22,,,,,,,,,,,, ,117.36,,,,,,,,,,,, ,133.46,,,,,,,,,,,, ,119.22,,,,,,,,,,,, ,127.96,,,,,,,,,,,, ,133.05,,,,,,,,,,,, ,126.26,,,,,,,,,,,, ,125.82,,,,,,,,,,,, ,144.44,,,,,,,,,,,, ,127.42,,,,,,,,,,,, ,149.29,,,,,,,,,,,, ,126.28,,,,,,,,,,,, ,125.98,,,,,,,,,,,, ,151.04,,,,,,,,,,,, ,143.49,,,,,,,,,,,, ,145.63,,,,,,,,,,,, ,132.32,,,,,,,,,,,, ,110.86,,,,,,,,,,,, ,117.86,,,,,,,,,,,, ,139.04,,,,,,,,,,,, ,146.86,,,,,,,,,,,, ,144.44,,,,,,,,,,,, ,148.32,,,,,,,,,,,, ,149.73,,,,,,,,,,,, ,133.33,,,,,,,,,,,, ,129.54,,,,,,,,,,,, ,138.29,,,,,,,,,,,, ,126.77,,,,,,,,,,,, ,116.45,,,,,,,,,,,, ,130.54,,,,,,,,,,,, ,125.96,,,,,,,,,,,, ,115.3,,,,,,,,,,,, ,111.17,,,,,,,,,,,, ,120.98,,,,,,,,,,,, ,114.54,,,,,,,,,,,, ,143.18,,,,,,,,,,,, ,140.11,,,,,,,,,,,, ,147.44,,,,,,,,,,,, ,142.04,,,,,,,,,,,, ,150.23,,,,,,,,,,,, ,144.71,,,,,,,,,,,, ,136.72,,,,,,,,,,,, ,148.42,,,,,,,,,,,, ,139.81,,,,,,,,,,,, ,152.62,,,,,,,,,,,, ,137.29,,,,,,,,,,,, ,156.85,,,,,,,,,,,, ,128.97,,,,,,,,,,,, ,135.48,,,,,,,,,,,, ,136.18,,,,,,,,,,,, ,124.52,,,,,,,,,,,, ,116.58,,,,,,,,,,,, ,137.29,,,,,,,,,,,, ,112.93,,,,,,,,,,,, ,115.06,,,,,,,,,,,, ,117.56,,,,,,,,,,,, ,126.86,,,,,,,,,,,, ,126.14,,,,,,,,,,,, ,123.11,,,,,,,,,,,, ,134.04,,,,,,,,,,,, ,117.29,,,,,,,,,,,, ,132.98,,,,,,,,,,,, ,136.56,,,,,,,,,,,, ,144.84,,,,,,,,,,,, ,129.55,,,,,,,,,,,, ,132.32,,,,,,,,,,,, ,131.1,,,,,,,,,,,, ,142.4,,,,,,,,,,,, ,142.44,,,,,,,,,,,, ,139.78,,,,,,,,,,,, ,146.29,,,,,,,,,,,, ,149.5,,,,,,,,,,,, ,140.13,,,,,,,,,,,, ,141.14,,,,,,,,,,,, ,146.5,,,,,,,,,,,, ,138.52,,,,,,,,,,,, ,146.82,,,,,,,,,,,, ,130.96,,,,,,,,,,,, ,142.69,,,,,,,,,,,, ,131.6,,,,,,,,,,,, ,137.23,,,,,,,,,,,, ,126.58,,,,,,,,,,,, ,129.7,,,,,,,,,,,, ,138.26,,,,,,,,,,,, ,125.37,,,,,,,,,,,, ,125.03,,,,,,,,,,,, ,119.12,,,,,,,,,,,, ,118.05,,,,,,,,,,,,