PFAM_key,PFAM,PFAM_desc,Total Number,Smina Failures,Machine Learning Failures ,Machine Learning Failures (RMSD+CS) PF00135,COesterase,Carboxylesterase family,81,34,34,18 PF00069,Pkinase,Protein kinase domain,1243,388,191,36 PF07714,Pkinase_Tyr,Protein tyrosine kinase,728,155,54,7 PF02984,Cyclin_C,"Cyclin, C-terminal domain",68,33,12,2 PF00026,Asp,Eukaryotic aspartyl protease,461,89,65,5 PF00089,Trypsin,Trypsin,528,91,66,13 PF00104,Hormone_recep,Ligand-binding domain of nuclear hormone receptor,364,49,49,14 PF00998,RdRP_3,Viral RNA dependent RNA polymerase,106,23,12,5 PF00439,Bromodomain,Bromodomain,313,153,81,22 PF00074,RnaseA,Pancreatic ribonuclease,52,27,13,1 PF00561,Abhydrolase_1,alpha/beta hydrolase fold,102,42,36,12 PF00576,Transthyretin,HIUase/Transthyretin family,62,33,28,15 PF00557,Peptidase_M24,Metallopeptidase family M24,74,26,14,1 PF00850,Hist_deacetyl,Histone deacetylase domain,54,16,10,1 PF01382,Avidin,Avidin family,57,9,5,1 PF10613,Lig_chan-Glu_bd,Ligated ion channel L-glutamate- and glycine-binding site,136,16,8,0 PF00704,Glyco_hydro_18,Glycosyl hydrolases family 18,67,29,6,1 PF00077,RVP,Retroviral aspartyl protease,407,47,29,3 PF00348,polyprenyl_synt,Polyprenyl synthetase,73,26,17,3 PF00497,SBP_bac_3,"Bacterial extracellular solute-binding proteins, family 3",41,5,7,0 PF00144,Beta-lactamase,Beta-lactamase,88,38,22,4 PF00102,Y_phosphatase,Protein-tyrosine phosphatase,115,19,13,3 PF00644,PARP,Poly(ADP-ribose) polymerase catalytic domain,153,27,11,1 PF14670,FXa_inhibition,Coagulation Factor Xa inhibitory site,114,12,4,0 PF00400,WD40,"WD domain, G-beta repeat",65,14,7,0 PF07654,C1-set,Immunoglobulin C1-set domain,208,50,43,8 PF00183,HSP90,Hsp90 protein,170,34,42,19 PF00233,PDEase_I,3'5'-cyclic nucleotide phosphodiesterase,204,83,51,20 PF13354,Beta-lactamase2,Beta-lactamase enzyme family,50,24,12,5 PF00454,PI3_PI4_kinase,Phosphatidylinositol 3- and 4-kinase,94,34,8,1 PF00194,Carb_anhydrase,Eukaryotic-type carbonic anhydrase,397,176,58,8 PF00343,Phosphorylase,Carbohydrate phosphorylase,104,27,26,8 PF06815,RVT_connect,Reverse transcriptase connection domain,72,9,12,7 PF00413,Peptidase_M10,Matrixin,146,48,31,5 PF04253,TFR_dimer,Transferrin receptor-like dimerisation domain,49,13,17,1 PF02201,SWIB,SWIB/MDM2 domain,69,10,7,0 PF00112,Peptidase_C1,Papain family cysteine protease,97,33,12,2 PF00653,BIR,Inhibitor of Apoptosis domain,65,6,3,0 PF02931,Neur_chan_LBD,Neurotransmitter-gated ion-channel ligand binding domain,65,19,14,3 PF00753,Lactamase_B,Metallo-beta-lactamase superfamily,51,22,25,13 PF00246,Peptidase_M14,Zinc carboxypeptidase,43,3,8,2 PF00595,PDZ,PDZ domain (Also known as DHR or GLGF),44,15,3,0 PF00244,14/03/2003,14-3-3 protein,42,8,1,0 PF00017,SH2,SH2 domain,61,21,19,6 PF00326,Peptidase_S9,Prolyl oligopeptidase family,93,16,5,0 PF02518,HATPase_c,"Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase",53,17,6,2 PF00656,Peptidase_C14,Caspase domain,57,18,11,2 PF02827,PKI,cAMP-dependent protein kinase inhibitor,64,18,6,0 PF00432,Prenyltrans,Prenyltransferase and squalene oxidase repeat,43,10,9,1 PF00665,rve,Integrase core domain,50,20,16,5 PF00232,Glyco_hydro_1,Glycosyl hydrolase family 1,47,11,2,1 PF01048,PNP_UDP_1,Phosphorylase superfamily,68,15,5,0 PF00491,Arginase,Arginase family,45,14,13,2 PF00064,Neur,Neuraminidase,56,13,5,2 PF00061,Lipocalin,Lipocalin / cytosolic fatty-acid binding protein family,105,40,45,14 PF00254,FKBP_C,FKBP-type peptidyl-prolyl cis-trans isomerase,41,7,3,1 PF00496,SBP_bac_5,"Bacterial extracellular solute-binding proteins, family 5 Middle",50,5,3,1 PF01327,Pep_deformylase,Polypeptide deformylase,41,7,9,0