ONTOLOGY,ID,Description,GeneRatio,BgRatio,pvalue,p.adjust,qvalue,geneID,Count
BP,GO:0032496,response to lipopolysaccharide,39/160,330/18670,1.98E-33,7.92E-30,3.71E-30,NOS2/PTGS2/MAPK14/RELA/AKT1/CASP9/JUN/CASP3/CCL2/CXCL8/OPRM1/CASP8/PRKCA/CYP1A2/FOS/MAPK1/IL10RA/NFKBIA/GJA1/CYP1A1/ICAM1/IL1B/SELE/VCAM1/NOS3/THBD/SERPINE1/MPO/GSTP1/CXCL11/CXCL2/PPARD/CXCL10/CHUK/CDK4/UGT1A1/MAPK8/SLPI/CASP1,39
BP,GO:0002237,response to molecule of bacterial origin,39/160,343/18670,9.00E-33,1.80E-29,8.45E-30,NOS2/PTGS2/MAPK14/RELA/AKT1/CASP9/JUN/CASP3/CCL2/CXCL8/OPRM1/CASP8/PRKCA/CYP1A2/FOS/MAPK1/IL10RA/NFKBIA/GJA1/CYP1A1/ICAM1/IL1B/SELE/VCAM1/NOS3/THBD/SERPINE1/MPO/GSTP1/CXCL11/CXCL2/PPARD/CXCL10/CHUK/CDK4/UGT1A1/MAPK8/SLPI/CASP1,39
BP,GO:0062197,cellular response to chemical stress,37/160,350/18670,6.67E-30,8.90E-27,4.17E-27,PPARG/PTGS2/CDK2/RELA/AKT1/BCL2/JUN/CASP3/TP53/MCL1/CCNA2/MMP2/MMP9/MMP3/EGFR/FOS/MAPK1/SOD1/HIF1A/HMOX1/CAV1/NOS3/HSPB1/CYP1B1/MPO/NCF1/GSTP1/NFE2L2/NQO1/PARP1/SLC2A4/CHUK/MDM2/MET/G6PD/MAPK8/CAT,37
BP,GO:0010038,response to metal ion,37/160,362/18670,2.30E-29,2.30E-26,1.08E-26,SCN5A/PTGS2/AKT1/CCND1/BCL2/CASP9/JUN/CASP3/SLC6A3/CASP8/CA2/MMP9/CYP1A2/EGFR/FOS/MAPK1/SOD1/HIF1A/HSPA5/HMOX1/CAV1/CYP1A1/ICAM1/VCAM1/CCNB1/IL1A/NCF1/NQO1/PARP1/CHUK/CDK4/MDM2/APP/G6PD/MAPK8/PPP3CA/CAT,37
BP,GO:0031667,response to nutrient levels,41/160,499/18670,8.61E-29,6.89E-26,3.23E-26,PPARG/PTGS2/ADRB2/RELA/AKT1/CCND1/BCL2/CDKN1A/JUN/TP53/SLC6A4/OPRM1/PON1/ADRB1/F7/EGFR/MAPK1/POR/SOD1/STAT1/HSPA5/HMOX1/CYP1A1/ICAM1/IL1B/VCAM1/COL1A1/MPO/GSTP1/NFE2L2/NQO1/PPARA/PPARD/CXCL10/SPP1/MDM2/TYR/G6PD/UGT1A1/MAPK8/CAT,41
BP,GO:0006979,response to oxidative stress,38/160,451/18670,4.74E-27,3.16E-24,1.48E-24,PTGS1/PTGS2/CDK2/RELA/AKT1/BCL2/JUN/CASP3/TP53/MCL1/CCNA2/MMP2/MMP9/MMP3/EGFR/FOS/MAPK1/SOD1/HIF1A/STAT1/HMOX1/NOS3/HSPB1/CYP1B1/COL1A1/MPO/NCF1/GSTP1/NFE2L2/NQO1/PARP1/CHUK/MDM2/APP/MET/G6PD/MAPK8/CAT,38
BP,GO:0034599,cellular response to oxidative stress,32/160,302/18670,6.83E-26,3.91E-23,1.83E-23,CDK2/RELA/AKT1/BCL2/JUN/TP53/MCL1/CCNA2/MMP2/MMP9/MMP3/EGFR/FOS/MAPK1/SOD1/HIF1A/HMOX1/NOS3/HSPB1/CYP1B1/MPO/NCF1/GSTP1/NFE2L2/NQO1/PARP1/CHUK/MDM2/MET/G6PD/MAPK8/CAT,32
BP,GO:0070482,response to oxygen levels,35/160,394/18670,1.11E-25,5.56E-23,2.61E-23,NOS2/PPARG/PTGS2/DPP4/AKT1/BCL2/CDKN1A/CASP3/TP53/SLC6A4/PLAU/F7/CCNA2/MMP2/VEGFA/RAF1/HIF1A/HMOX1/CAV1/MYC/CYP1A1/ICAM1/VCAM1/CCNB1/PLAT/COL1A1/NFE2L2/SLC2A4/PPARA/PPARD/E2F1/HK2/CDK4/MDM2/CAT,35
BP,GO:0000302,response to reactive oxygen species,29/160,232/18670,1.40E-25,6.25E-23,2.93E-23,CDK2/RELA/AKT1/BCL2/JUN/CASP3/CCNA2/MMP2/MMP9/MMP3/EGFR/FOS/MAPK1/SOD1/STAT1/HMOX1/NOS3/CYP1B1/COL1A1/MPO/NCF1/GSTP1/NFE2L2/NQO1/CHUK/MDM2/MET/MAPK8/CAT,29
BP,GO:0046677,response to antibiotic,32/160,327/18670,8.41E-25,3.37E-22,1.58E-22,RELA/CCND1/BCL2/CASP9/JUN/CASP3/TP53/SLC6A3/OPRM1/CASP8/HTR3A/BCL2L1/SOD1/STAT1/HSPA5/HMOX1/CYP1A1/ICAM1/VCAM1/CYP1B1/COL1A1/GSTP1/NFE2L2/NQO1/SLC2A4/CHUK/MDM2/ADCY2/MET/G6PD/UGT1A1/CAT,32
BP,GO:0009410,response to xenobiotic stimulus,30/160,292/18670,6.78E-24,2.47E-21,1.16E-21,PTGS1/PPARG/RELA/CASP9/SLC6A3/OPRM1/F7/CCNA2/HTR3A/CYP3A4/CYP1A2/CYP2B6/EGFR/RB1/POR/SOD1/HSPA5/CYP1A1/ICAM1/NR1I2/CYP1B1/GSTP1/NQO1/CHEK2/E2F1/GSTM1/NR3C1/MDM2/UGT1A1/PPP3CA,30
BP,GO:0048545,response to steroid hormone,33/160,383/18670,8.56E-24,2.86E-21,1.34E-21,ESR1/AR/PPARG/PTGS2/RXRA/RELA/CCND1/BCL2/CDKN1A/CASP9/CASP3/PGR/ESR2/CA2/EGFR/FOS/RB1/CAV1/ICAM1/NR1I2/COL1A1/GSTP1/PARP1/NR1I3/CLDN4/PPARA/PPARD/SPP1/NR3C1/HSD3B2/HSD3B1/MDM2/UGT1A1,33
BP,GO:0001666,response to hypoxia,31/160,359/18670,2.14E-22,6.59E-20,3.09E-20,NOS2/PTGS2/DPP4/AKT1/BCL2/CASP3/TP53/SLC6A4/PLAU/F7/CCNA2/MMP2/VEGFA/RAF1/HIF1A/HMOX1/CAV1/MYC/CYP1A1/ICAM1/VCAM1/CCNB1/PLAT/NFE2L2/SLC2A4/PPARA/PPARD/E2F1/HK2/MDM2/CAT,31
BP,GO:0036293,response to decreased oxygen levels,31/160,370/18670,5.27E-22,1.51E-19,7.06E-20,NOS2/PTGS2/DPP4/AKT1/BCL2/CASP3/TP53/SLC6A4/PLAU/F7/CCNA2/MMP2/VEGFA/RAF1/HIF1A/HMOX1/CAV1/MYC/CYP1A1/ICAM1/VCAM1/CCNB1/PLAT/NFE2L2/SLC2A4/PPARA/PPARD/E2F1/HK2/MDM2/CAT,31
BP,GO:0072593,reactive oxygen species metabolic process,28/160,284/18670,7.69E-22,2.05E-19,9.61E-20,NOS2/PTGS2/MAPK14/AKT1/BCL2/CDKN1A/TP53/CYP1A2/MMP3/EGFR/POR/SOD1/HIF1A/CAV1/CYP1A1/ICAM1/IL1B/NOS3/CYP1B1/IFNG/MPO/NCF1/GSTP1/NFE2L2/NQO1/HK2/G6PD/CAT,28
BP,GO:0035690,cellular response to drug,32/160,433/18670,4.84E-21,1.21E-18,5.68E-19,NOS2/PTGS2/CDK2/RELA/CASP9/KDR/TP53/CHRM3/CHRM1/OPRM1/CCNA2/HTR3A/MMP3/EGFR/MAPK1/SOD1/HSPA5/HMOX1/MYC/ICAM1/IL1B/CYP1B1/NFE2L2/NQO1/CHEK2/NR3C1/CDK4/MDM2/ADCY2/MET/UGT1A1/PPP3CA,32
BP,GO:0097305,response to alcohol,25/160,233/18670,1.78E-20,4.20E-18,1.97E-18,PPARG/AKT1/CCND1/CDKN1A/SLC6A3/OPRM1/CASP8/F7/HTR3A/BCL2L1/FOS/SOD1/ICAM1/VCAM1/GSTP1/NQO1/PARP1/SLC2A4/HSD3B2/HSD3B1/CDK4/ADCY2/G6PD/UGT1A1/CAT,25
BP,GO:0034614,cellular response to reactive oxygen species,22/160,168/18670,5.05E-20,1.12E-17,5.27E-18,CDK2/RELA/AKT1/JUN/CCNA2/MMP2/MMP9/MMP3/EGFR/FOS/MAPK1/SOD1/NOS3/CYP1B1/MPO/NCF1/NFE2L2/NQO1/CHUK/MDM2/MET/MAPK8,22
BP,GO:0007584,response to nutrient,24/160,219/18670,6.63E-20,1.40E-17,6.55E-18,PPARG/PTGS2/RELA/CCND1/SLC6A4/F7/EGFR/POR/SOD1/STAT1/HMOX1/CYP1A1/IL1B/VCAM1/COL1A1/GSTP1/NQO1/PPARD/CXCL10/SPP1/MDM2/TYR/UGT1A1/CAT,24
BP,GO:2001233,regulation of apoptotic signaling pathway,30/160,406/18670,9.52E-20,1.90E-17,8.93E-18,AR/PTGS2/RELA/AKT1/BCL2/BAX/TP53/MCL1/CASP8/MMP9/BCL2L1/RB1/RAF1/SOD1/HIF1A/HMOX1/CAV1/ICAM1/IL1B/NOS3/HSPB1/SERPINE1/IL1A/GSTP1/NFE2L2/PARP1/E2F1/CD44/MDM2/MAPK8,30
BP,GO:2001234,negative regulation of apoptotic signaling pathway,24/160,230/18670,2.12E-19,4.04E-17,1.90E-17,AR/PTGS2/RELA/AKT1/BCL2/BAX/MCL1/CASP8/MMP9/BCL2L1/RB1/RAF1/HIF1A/HMOX1/ICAM1/IL1B/NOS3/HSPB1/SERPINE1/IL1A/GSTP1/NFE2L2/CD44/MDM2,24
BP,GO:0071241,cellular response to inorganic substance,23/160,215/18670,7.17E-19,1.30E-16,6.11E-17,SCN5A/PTGS2/CDK2/AKT1/JUN/CCNA2/MMP9/CYP1A2/MMP3/EGFR/FOS/MAPK1/SOD1/HSPA5/HMOX1/CYP1A1/CCNB1/NCF1/NQO1/PARP1/CHUK/APP/MAPK8,23
BP,GO:0009314,response to radiation,30/160,448/18670,1.52E-18,2.64E-16,1.24E-16,PTGS2/MAPK14/RELA/AKT1/CCND1/BCL2/CDKN1A/BAX/CASP9/JUN/CASP3/TP53/OPRM1/EGFR/BCL2L1/FOS/HIF1A/HSPA5/MYC/ICAM1/VCAM1/THBD/PARP1/CHEK2/CXCL10/MDM2/APP/TYR/MAPK8/CAT,30
BP,GO:0071466,cellular response to xenobiotic stimulus,21/160,180/18670,4.29E-18,7.15E-16,3.35E-16,PTGS1/CASP9/OPRM1/CCNA2/CYP3A4/CYP1A2/CYP2B6/EGFR/RB1/POR/CYP1A1/ICAM1/NR1I2/CYP1B1/GSTP1/NQO1/CHEK2/E2F1/GSTM1/NR3C1/UGT1A1,21
BP,GO:0071216,cellular response to biotic stimulus,23/160,236/18670,5.89E-18,9.43E-16,4.42E-16,NOS2/MAPK14/RELA/AKT1/TP53/CCL2/CXCL8/PRKCA/MAPK1/NFKBIA/HSPA5/ICAM1/IL1B/NOS3/SERPINE1/GSTP1/CXCL11/CXCL2/PPARD/CXCL10/CDK4/MAPK8/CASP1,23
BP,GO:0009612,response to mechanical stimulus,22/160,210/18670,6.84E-18,1.05E-15,4.93E-16,PPARG/PTGS2/MAPK14/RELA/AKT1/JUN/CASP8/EGFR/FOS/NFKBIA/RAF1/STAT1/GJA1/IL1B/CCNB1/COL1A1/MPO/CXCL10/IRF1/MAPK8/CASP1/MAP2K4,22
BP,GO:0071496,cellular response to external stimulus,26/160,339/18670,1.36E-17,2.02E-15,9.46E-16,PPARG/PTGS2/AKT1/BCL2/CDKN1A/JUN/TP53/CASP8/EGFR/FOS/MAPK1/SOD1/HSPA5/HMOX1/GJA1/ICAM1/IL1B/VCAM1/COL1A1/GSTP1/NFE2L2/IRF1/MDM2/MAPK8/CASP1/MAP2K4,26
BP,GO:1901654,response to ketone,21/160,193/18670,1.84E-17,2.63E-15,1.23E-15,AR/PPARG/RELA/AKT1/CCND1/CDKN1A/CASP9/F7/EGFR/BCL2L1/FOS/CAV1/ICAM1/PARP1/CLDN4/SPP1/NR3C1/HSD3B2/HSD3B1/CDK4/ADCY2,21
BP,GO:0044706,multi-multicellular organism process,22/160,222/18670,2.27E-17,3.13E-15,1.47E-15,ESR1/AR/PTGS2/RXRA/AKT1/BCL2/PGR/SLC6A4/MMP2/MMP9/ADRA2C/ADRA2B/FOS/MAPK1/SOD1/GJA1/CYP1A1/IL1B/THBD/CLDN4/PPARD/SPP1,22
BP,GO:0097191,extrinsic apoptotic signaling pathway,22/160,224/18670,2.75E-17,3.67E-15,1.72E-15,AR/RELA/AKT1/BCL2/BAX/CASP9/IL6R/CASP3/MCL1/CASP8/BCL2L1/RAF1/HMOX1/CAV1/ICAM1/IL1B/NOS3/SERPINE1/IFNG/IL1A/GSTP1/ERBB3,22
BP,GO:0097193,intrinsic apoptotic signaling pathway,24/160,289/18670,4.35E-17,5.62E-15,2.63E-15,PTGS2/AKT1/BCL2/CDKN1A/BAX/CASP9/CASP3/TP53/MCL1/MMP9/BCL2L1/SOD1/HIF1A/HMOX1/CAV1/HSPB1/CYP1B1/NFE2L2/PARP1/CHEK2/E2F1/E2F2/CD44/MDM2,24
BP,GO:0071222,cellular response to lipopolysaccharide,21/160,205/18670,6.41E-17,8.02E-15,3.76E-15,NOS2/MAPK14/RELA/AKT1/CCL2/CXCL8/PRKCA/MAPK1/NFKBIA/ICAM1/IL1B/NOS3/SERPINE1/GSTP1/CXCL11/CXCL2/PPARD/CXCL10/CDK4/MAPK8/CASP1,21
BP,GO:0071214,cellular response to abiotic stimulus,25/160,331/18670,8.69E-17,1.02E-14,4.79E-15,PTGS2/MAPK14/AKT1/CDKN1A/BAX/CASP9/CASP3/TP53/CASP8/EGFR/BCL2L1/HSPA5/MYC/GJA1/IL1B/COL1A1/PARP1/SLC2A4/CHEK2/INSRR/IRF1/MDM2/MAPK8/CASP1/MAP2K4,25
BP,GO:0104004,cellular response to environmental stimulus,25/160,331/18670,8.69E-17,1.02E-14,4.79E-15,PTGS2/MAPK14/AKT1/CDKN1A/BAX/CASP9/CASP3/TP53/CASP8/EGFR/BCL2L1/HSPA5/MYC/GJA1/IL1B/COL1A1/PARP1/SLC2A4/CHEK2/INSRR/IRF1/MDM2/MAPK8/CASP1/MAP2K4,25
BP,GO:0071219,cellular response to molecule of bacterial origin,21/160,212/18670,1.28E-16,1.46E-14,6.86E-15,NOS2/MAPK14/RELA/AKT1/CCL2/CXCL8/PRKCA/MAPK1/NFKBIA/ICAM1/IL1B/NOS3/SERPINE1/GSTP1/CXCL11/CXCL2/PPARD/CXCL10/CDK4/MAPK8/CASP1,21
BP,GO:0071276,cellular response to cadmium ion,12/160,37/18670,1.59E-16,1.77E-14,8.29E-15,AKT1/JUN/MMP9/CYP1A2/EGFR/FOS/MAPK1/SOD1/HMOX1/NCF1/CHUK/MAPK8,12
BP,GO:0071248,cellular response to metal ion,20/160,188/18670,1.75E-16,1.89E-14,8.87E-15,SCN5A/PTGS2/AKT1/JUN/MMP9/CYP1A2/EGFR/FOS/MAPK1/SOD1/HSPA5/HMOX1/CYP1A1/CCNB1/NCF1/NQO1/PARP1/CHUK/APP/MAPK8,20
BP,GO:0007565,female pregnancy,20/160,192/18670,2.65E-16,2.79E-14,1.31E-14,ESR1/AR/PTGS2/RXRA/AKT1/BCL2/PGR/MMP2/MMP9/ADRA2C/ADRA2B/FOS/MAPK1/SOD1/GJA1/IL1B/THBD/CLDN4/PPARD/SPP1,20
BP,GO:0070997,neuron death,25/160,348/18670,2.82E-16,2.90E-14,1.36E-14,AKT1/BCL2/BAX/CASP9/JUN/CASP3/TP53/CCL2/MCL1/CASP8/BCL2L1/FOS/RB1/SOD1/HIF1A/HSPA5/HMOX1/IFNG/NQO1/PARP1/PPARA/ERBB3/APP/G6PD/MAP2K4,25
BP,GO:0035296,regulation of tube diameter,18/160,143/18670,3.00E-16,2.93E-14,1.37E-14,PTGS2/ADRB2/AKT1/CHRM3/SLC6A4/ADRA2A/ADRB1/ADRA2C/ADRA2B/EGFR/SOD1/HMOX1/CAV1/GJA1/ICAM1/NOS3/PPARD/ECE1,18
BP,GO:0097746,regulation of blood vessel diameter,18/160,143/18670,3.00E-16,2.93E-14,1.37E-14,PTGS2/ADRB2/AKT1/CHRM3/SLC6A4/ADRA2A/ADRB1/ADRA2C/ADRA2B/EGFR/SOD1/HMOX1/CAV1/GJA1/ICAM1/NOS3/PPARD/ECE1,18
BP,GO:0035150,regulation of tube size,18/160,144/18670,3.40E-16,3.24E-14,1.52E-14,PTGS2/ADRB2/AKT1/CHRM3/SLC6A4/ADRA2A/ADRB1/ADRA2C/ADRA2B/EGFR/SOD1/HMOX1/CAV1/GJA1/ICAM1/NOS3/PPARD/ECE1,18
BP,GO:0007568,aging,24/160,321/18670,4.76E-16,4.43E-14,2.08E-14,PTGS2/MAPK14/RELA/AKT1/BCL2/CDKN1A/CASP9/JUN/TP53/SLC6A3/FOS/MAPK1/SOD1/CYP1A1/ICAM1/VCAM1/SERPINE1/MPO/NFE2L2/NQO1/CHEK2/APP/PPP3CA/CAT,24
BP,GO:0048732,gland development,27/160,434/18670,5.95E-16,5.41E-14,2.53E-14,ESR1/AR/RXRA/RELA/AKT1/CCND1/BCL2/BAX/JUN/PGR/SLC6A3/EGFR/VEGFA/MAPK1/EGF/RAF1/SOD1/HIF1A/HMOX1/CAV1/GJA1/CYP1A1/IGF2/HK2/TYR/MET/UGT1A1,27
BP,GO:0003018,vascular process in circulatory system,19/160,175/18670,7.08E-16,6.30E-14,2.95E-14,PTGS2/ADRB2/AKT1/CHRM3/SLC6A4/ADRA2A/ADRB1/ADRA2C/ADRA2B/EGFR/VEGFA/SOD1/HMOX1/CAV1/GJA1/ICAM1/NOS3/PPARD/ECE1,19
BP,GO:0033002,muscle cell proliferation,21/160,239/18670,1.47E-15,1.28E-13,6.00E-14,PPARG/PTGS2/RXRA/MAPK14/AKT1/CDKN1A/JUN/IL6R/MMP2/MMP9/EGFR/MAPK1/STAT1/HMOX1/GJA1/CCNB1/IFNG/GSTP1/PPARD/IGFBP3/MDM2,21
BP,GO:0032355,response to estradiol,17/160,134/18670,1.82E-15,1.55E-13,7.28E-14,ESR1/PTGS2/CCND1/CASP9/CASP3/SLC6A4/CASP8/F7/CCNA2/CYP1A2/EGFR/GJA1/COL1A1/GSTP1/NQO1/UGT1A1/CAT,17
BP,GO:0001101,response to acid chemical,24/160,343/18670,2.12E-15,1.77E-13,8.28E-14,PPARG/PTGS2/RXRA/RELA/AKT1/KDR/CASP3/SLC6A4/PON1/F7/MMP2/EGFR/VEGFA/BCL2L1/GJA1/ICAM1/CCNB1/COL1A1/GSTP1/NQO1/CHUK/E2F1/CDK4/CAT,24
BP,GO:0033273,response to vitamin,15/160,93/18670,2.23E-15,1.82E-13,8.53E-14,PPARG/PTGS2/RELA/CCND1/F7/EGFR/CYP1A1/COL1A1/GSTP1/PPARD/CXCL10/SPP1/MDM2/TYR/CAT,15
BP,GO:0006367,transcription initiation from RNA polymerase II promoter,19/160,188/18670,2.70E-15,2.17E-13,1.01E-13,ESR1/AR/PPARG/RXRA/CCND1/CDKN1A/BAX/TP53/PGR/ESR2/NR1I2/CCNB1/NR1I3/PPARA/PPARD/RUNX2/E2F2/NR3C1/CDK4,19
BP,GO:0009411,response to UV,17/160,141/18670,4.35E-15,3.42E-13,1.60E-13,PTGS2/RELA/AKT1/CCND1/BCL2/CDKN1A/BAX/CASP9/CASP3/TP53/EGFR/MYC/PARP1/MDM2/TYR/MAPK8/CAT,17
BP,GO:0048608,reproductive structure development,26/160,431/18670,4.53E-15,3.49E-13,1.64E-13,ESR1/AR/PPARG/PTGS2/RXRA/MAPK14/AKT1/CCND1/BCL2/BAX/CASP3/PGR/CASP8/EGFR/VEGFA/BCL2L1/MAPK1/SOD1/HIF1A/HSPA5/GJA1/ICAM1/NOS3/PPARD/SPP1/IGF2,26
BP,GO:2000377,regulation of reactive oxygen species metabolic process,19/160,195/18670,5.33E-15,3.89E-13,1.82E-13,PTGS2/MAPK14/AKT1/BCL2/CDKN1A/TP53/MMP3/EGFR/SOD1/HIF1A/CAV1/ICAM1/IL1B/CYP1B1/IFNG/GSTP1/NFE2L2/HK2/G6PD,19
BP,GO:0050673,epithelial cell proliferation,26/160,434/18670,5.35E-15,3.89E-13,1.82E-13,ESR1/AR/SCN5A/PPARG/AKT1/CCND1/BAX/KDR/JUN/CCL2/PGR/PRKCA/EGFR/VEGFA/MAPK1/RB1/HIF1A/STAT1/ERBB2/HMOX1/CAV1/MYC/F3/GJA1/PPARD/IGFBP3,26
BP,GO:0061458,reproductive system development,26/160,434/18670,5.35E-15,3.89E-13,1.82E-13,ESR1/AR/PPARG/PTGS2/RXRA/MAPK14/AKT1/CCND1/BCL2/BAX/CASP3/PGR/CASP8/EGFR/VEGFA/BCL2L1/MAPK1/SOD1/HIF1A/HSPA5/GJA1/ICAM1/NOS3/PPARD/SPP1/IGF2,26
BP,GO:0046686,response to cadmium ion,13/160,63/18670,5.94E-15,4.19E-13,1.96E-13,AKT1/JUN/MMP9/CYP1A2/EGFR/FOS/MAPK1/SOD1/HMOX1/NCF1/CHUK/MAPK8/CAT,13
BP,GO:0043434,response to peptide hormone,26/160,436/18670,5.96E-15,4.19E-13,1.96E-13,PPARG/PTGS2/RELA/AKT1/F7/CCNA2/CA2/POR/STAT1/CAV1/GJA1/ICAM1/IL1B/COL1A1/GSTP1/NFE2L2/PARP1/SLC2A4/INSRR/PPARA/CHUK/IGF2/CDK4/MDM2/ADCY2/CAT,26
BP,GO:0010212,response to ionizing radiation,17/160,147/18670,8.83E-15,6.09E-13,2.85E-13,MAPK14/CCND1/BCL2/CDKN1A/BAX/CASP3/TP53/BCL2L1/HSPA5/MYC/ICAM1/VCAM1/THBD/PARP1/CHEK2/CXCL10/MDM2,17
BP,GO:0008202,steroid metabolic process,23/160,331/18670,9.91E-15,6.72E-13,3.15E-13,ESR1/RXRA/PON1/CYP3A4/CYP1A2/IL4/CYP2B6/POR/SOD1/CYP1A1/IL1B/SULT1E1/NR1I2/CYP1B1/IFNG/PPARD/SPP1/HSD3B2/HSD3B1/APP/G6PD/UGT1A1/CAT,23
BP,GO:0048145,regulation of fibroblast proliferation,14/160,83/18670,1.03E-14,6.86E-13,3.21E-13,ESR1/PPARG/CDKN1A/BAX/JUN/TP53/FN1/CCNA2/EGFR/MYC/CCNB1/GSTP1/E2F1/CDK4,14
BP,GO:0048144,fibroblast proliferation,14/160,84/18670,1.22E-14,8.04E-13,3.77E-13,ESR1/PPARG/CDKN1A/BAX/JUN/TP53/FN1/CCNA2/EGFR/MYC/CCNB1/GSTP1/E2F1/CDK4,14
BP,GO:2001237,negative regulation of extrinsic apoptotic signaling pathway,15/160,104/18670,1.26E-14,8.10E-13,3.80E-13,AR/RELA/AKT1/BCL2/MCL1/CASP8/BCL2L1/RAF1/HMOX1/ICAM1/IL1B/NOS3/SERPINE1/IL1A/GSTP1,15
BP,GO:0051402,neuron apoptotic process,20/160,239/18670,1.85E-14,1.18E-12,5.52E-13,BCL2/BAX/CASP9/JUN/CASP3/TP53/CCL2/MCL1/BCL2L1/RB1/SOD1/HIF1A/HSPA5/HMOX1/NQO1/PARP1/ERBB3/APP/G6PD/MAP2K4,20
BP,GO:0048638,regulation of developmental growth,23/160,347/18670,2.72E-14,1.70E-12,7.96E-13,AR/MAPK14/ADRB2/AKT1/BCL2/CDKN1A/FN1/SLC6A3/SLC6A4/ADRB1/VEGFA/MAPK1/POR/SOD1/GJA1/CCNB1/PPARA/PPARD/SPP1/IGF2/CDK4/APP/G6PD,23
BP,GO:0034612,response to tumor necrosis factor,22/160,312/18670,2.92E-14,1.80E-12,8.43E-13,PTGS2/MAPK14/RELA/AKT1/CASP3/CCL2/CXCL8/CASP8/MAPK1/NFKBIA/STAT1/ICAM1/SELE/VCAM1/COL1A1/GSTP1/NFE2L2/SLC2A4/CHUK/CD40LG/IKBKB/CASP1,22
BP,GO:1901214,regulation of neuron death,22/160,313/18670,3.12E-14,1.89E-12,8.87E-13,AKT1/BCL2/BAX/CASP9/JUN/CASP3/TP53/CCL2/MCL1/CASP8/BCL2L1/FOS/SOD1/HIF1A/HMOX1/IFNG/NQO1/PARP1/PPARA/ERBB3/G6PD/MAP2K4,22
BP,GO:0006352,"DNA-templated transcription, initiation",20/160,249/18670,4.05E-14,2.42E-12,1.13E-12,ESR1/AR/PPARG/RXRA/CCND1/CDKN1A/BAX/JUN/TP53/PGR/ESR2/NR1I2/CCNB1/NR1I3/PPARA/PPARD/RUNX2/E2F2/NR3C1/CDK4,20
BP,GO:0051090,regulation of DNA-binding transcription factor activity,25/160,432/18670,4.13E-14,2.43E-12,1.14E-12,ESR1/AR/PPARG/MAPK14/RELA/AKT1/JUN/ESR2/VEGFA/FOS/MAPK1/RB1/NFKBIA/HMOX1/CAV1/ICAM1/IL1B/CYP1B1/CHUK/CD40LG/APP/IKBKB/MAPK8/PPP3CA/CAT,25
BP,GO:0018209,peptidyl-serine modification,22/160,322/18670,5.58E-14,3.23E-12,1.52E-12,PTGS2/MAPK14/CDK2/AKT1/BCL2/BAX/PRKCA/EGFR/VEGFA/MAPK1/TOP1/RAF1/CAV1/CCNB1/IFNG/PARP1/CHEK2/CHUK/CD44/APP/IKBKB/MAPK8,22
BP,GO:0051098,regulation of binding,23/160,373/18670,1.25E-13,7.16E-12,3.35E-12,PPARG/ADRB2/AKT1/BCL2/BAX/JUN/PON1/MMP9/EGF/RB1/NFKBIA/HSPA5/HMOX1/CAV1/IFNG/PARP1/PPARA/E2F1/APP/MET/MAPK8/PPP3CA/SLPI,23
BP,GO:0018105,peptidyl-serine phosphorylation,21/160,299/18670,1.27E-13,7.16E-12,3.35E-12,PTGS2/MAPK14/CDK2/AKT1/BCL2/BAX/PRKCA/EGFR/VEGFA/MAPK1/TOP1/RAF1/CAV1/CCNB1/IFNG/CHEK2/CHUK/CD44/APP/IKBKB/MAPK8,21
BP,GO:0050678,regulation of epithelial cell proliferation,23/160,378/18670,1.66E-13,9.21E-12,4.32E-12,AR/SCN5A/PPARG/AKT1/CCND1/BAX/KDR/JUN/CCL2/PGR/PRKCA/EGFR/VEGFA/RB1/HIF1A/STAT1/ERBB2/HMOX1/CAV1/MYC/F3/GJA1/PPARD,23
BP,GO:0042110,T cell activation,25/160,464/18670,2.06E-13,1.13E-11,5.30E-12,DPP4/AKT1/BCL2/BAX/IL6R/CASP3/TP53/CCL2/CASP8/IL4/SOD1/ERBB2/CAV1/GJA1/ICAM1/IL1B/VCAM1/IL2RA/IFNG/RUNX2/IGF2/CD40LG/IRF1/CD44/PPP3CA,25
BP,GO:1901653,cellular response to peptide,23/160,385/18670,2.43E-13,1.32E-11,6.17E-12,PPARG/ADRB2/RELA/AKT1/TP53/CCNA2/CA2/POR/STAT1/CAV1/ICAM1/IL1B/VCAM1/GSTP1/NFE2L2/PARP1/SLC2A4/INSRR/IGF2/CDK4/MDM2/APP/ADCY2,23
BP,GO:2001236,regulation of extrinsic apoptotic signaling pathway,16/160,155/18670,3.38E-13,1.81E-11,8.46E-12,AR/RELA/AKT1/BCL2/MCL1/CASP8/BCL2L1/RAF1/HMOX1/CAV1/ICAM1/IL1B/NOS3/SERPINE1/IL1A/GSTP1,16
BP,GO:0043281,regulation of cysteine-type endopeptidase activity involved in apoptotic process,18/160,215/18670,4.02E-13,2.12E-11,9.93E-12,PPARG/PTGS2/AKT1/BAX/CASP9/CASP8/MMP9/VEGFA/POR/RAF1/MYC/F3/BIRC5/CTSD/CD44/MDM2/XIAP/CASP1,18
BP,GO:0031960,response to corticosteroid,16/160,162/18670,6.75E-13,3.51E-11,1.65E-11,PTGS2/CCND1/BCL2/CDKN1A/CASP9/CASP3/EGFR/FOS/ICAM1/COL1A1/GSTP1/PARP1/NR3C1/HSD3B2/HSD3B1/UGT1A1,16
BP,GO:0052547,regulation of peptidase activity,24/160,452/18670,8.97E-13,4.56E-11,2.13E-11,PPARG/PTGS2/MAPK14/AKT1/BAX/CASP9/FN1/CASP8/MMP9/VEGFA/POR/RAF1/CAV1/MYC/F3/BIRC5/SERPINE1/CTSD/CD44/MDM2/APP/XIAP/SLPI/CASP1,24
BP,GO:2001242,regulation of intrinsic apoptotic signaling pathway,16/160,165/18670,8.99E-13,4.56E-11,2.13E-11,PTGS2/AKT1/BCL2/BAX/TP53/MCL1/MMP9/BCL2L1/SOD1/HIF1A/CAV1/HSPB1/NFE2L2/PARP1/CD44/MDM2,16
BP,GO:0031099,regeneration,17/160,198/18670,1.24E-12,6.21E-11,2.91E-11,PPARG/CCND1/BCL2/CDKN1A/JUN/F7/CCNA2/EGFR/HMOX1/GJA1/CCNB1/GSTP1/PPARD/SPP1/CDK4/UGT1A1/PPP3CA,17
BP,GO:0048660,regulation of smooth muscle cell proliferation,16/160,169/18670,1.30E-12,6.45E-11,3.02E-11,PPARG/PTGS2/AKT1/CDKN1A/JUN/IL6R/MMP2/MMP9/EGFR/STAT1/HMOX1/IFNG/GSTP1/PPARD/IGFBP3/MDM2,16
BP,GO:0010332,response to gamma radiation,11/160,56/18670,1.38E-12,6.75E-11,3.16E-11,BCL2/CDKN1A/BAX/TP53/BCL2L1/HSPA5/MYC/PARP1/CHEK2/CXCL10/MDM2,11
BP,GO:0048659,smooth muscle cell proliferation,16/160,171/18670,1.57E-12,7.55E-11,3.54E-11,PPARG/PTGS2/AKT1/CDKN1A/JUN/IL6R/MMP2/MMP9/EGFR/STAT1/HMOX1/IFNG/GSTP1/PPARD/IGFBP3/MDM2,16
BP,GO:0071453,cellular response to oxygen levels,18/160,234/18670,1.71E-12,8.15E-11,3.82E-11,PPARG/PTGS2/AKT1/BCL2/TP53/CCNA2/VEGFA/HIF1A/HMOX1/CAV1/MYC/ICAM1/CCNB1/NFE2L2/SLC2A4/PPARD/E2F1/MDM2,18
BP,GO:0006631,fatty acid metabolic process,22/160,383/18670,1.84E-12,8.67E-11,4.06E-11,PTGS1/PPARG/PTGS2/MAPK14/AKT1/PON1/LTA4H/CYP3A4/CYP1A2/CYP2B6/POR/CAV1/CYP1A1/IL1B/CYP1B1/ALOX5/GSTP1/PPARA/PPARD/ACOX1/EHHADH/HADHB,22
BP,GO:0042310,vasoconstriction,12/160,76/18670,2.00E-12,9.31E-11,4.36E-11,PTGS2/AKT1/CHRM3/SLC6A4/ADRA2A/ADRA2C/ADRA2B/EGFR/CAV1/GJA1/ICAM1/ECE1,12
BP,GO:0019229,regulation of vasoconstriction,11/160,58/18670,2.08E-12,9.59E-11,4.49E-11,PTGS2/AKT1/CHRM3/ADRA2A/ADRA2C/ADRA2B/EGFR/CAV1/GJA1/ICAM1/ECE1,11
BP,GO:2000116,regulation of cysteine-type endopeptidase activity,18/160,239/18670,2.45E-12,1.11E-10,5.21E-11,PPARG/PTGS2/AKT1/BAX/CASP9/CASP8/MMP9/VEGFA/POR/RAF1/MYC/F3/BIRC5/CTSD/CD44/MDM2/XIAP/CASP1,18
BP,GO:1903409,reactive oxygen species biosynthetic process,14/160,122/18670,2.50E-12,1.11E-10,5.22E-11,NOS2/PTGS2/AKT1/CYP1A2/SOD1/CAV1/CYP1A1/ICAM1/IL1B/NOS3/CYP1B1/IFNG/MPO/NQO1,14
BP,GO:0061041,regulation of wound healing,15/160,148/18670,2.50E-12,1.11E-10,5.22E-11,CDKN1A/PRKCA/ADRA2A/PLAU/F7/CAV1/F3/GJA1/NOS3/PLAT/THBD/SERPINE1/NFE2L2/PPARD/HPSE,15
BP,GO:0014074,response to purine-containing compound,15/160,149/18670,2.76E-12,1.22E-10,5.70E-11,PPARG/PTGS2/RELA/JUN/SLC6A3/SLC6A4/FOS/SOD1/STAT1/HSPA5/IL1B/THBD/COL1A1/APP/TYR,15
BP,GO:0009416,response to light stimulus,20/160,314/18670,3.09E-12,1.34E-10,6.29E-11,PTGS2/RELA/AKT1/CCND1/BCL2/CDKN1A/BAX/CASP9/CASP3/TP53/EGFR/FOS/HIF1A/MYC/PARP1/MDM2/APP/TYR/MAPK8/CAT,20
BP,GO:1903034,regulation of response to wounding,16/160,179/18670,3.17E-12,1.37E-10,6.40E-11,CDKN1A/PRKCA/ADRA2A/PLAU/F7/CAV1/F3/GJA1/NOS3/PLAT/THBD/SERPINE1/NFE2L2/PPARD/SPP1/HPSE,16
BP,GO:0043523,regulation of neuron apoptotic process,17/160,210/18670,3.22E-12,1.37E-10,6.43E-11,BCL2/BAX/CASP9/JUN/CASP3/TP53/CCL2/MCL1/BCL2L1/SOD1/HIF1A/HMOX1/NQO1/PARP1/ERBB3/G6PD/MAP2K4,17
BP,GO:0045471,response to ethanol,14/160,125/18670,3.50E-12,1.47E-10,6.91E-11,CCND1/SLC6A3/OPRM1/CASP8/HTR3A/SOD1/ICAM1/VCAM1/GSTP1/NQO1/SLC2A4/G6PD/UGT1A1/CAT,14
BP,GO:0042133,neurotransmitter metabolic process,15/160,153/18670,4.07E-12,1.70E-10,7.96E-11,NOS2/PTGS2/AKT1/ACHE/SLC6A3/SLC6A4/MAOA/POR/CAV1/ICAM1/IL1B/NOS3/CYP1B1/IFNG/NQO1,15
BP,GO:0097237,cellular response to toxic substance,18/160,247/18670,4.27E-12,1.76E-10,8.25E-11,PTGS1/PTGS2/RELA/KDR/SOD1/HMOX1/NOS3/CYP1B1/MPO/ABCG2/GSTP1/NFE2L2/NQO1/GSTM1/MDM2/MET/UGT1A1/CAT,18
BP,GO:0071383,cellular response to steroid hormone stimulus,18/160,248/18670,4.57E-12,1.87E-10,8.74E-11,ESR1/AR/PPARG/RXRA/CASP9/PGR/ESR2/EGFR/RB1/ICAM1/NR1I2/GSTP1/PARP1/NR1I3/PPARA/PPARD/NR3C1/UGT1A1,18
BP,GO:0022407,regulation of cell-cell adhesion,22/160,402/18670,4.80E-12,1.94E-10,9.09E-11,DPP4/MAPK14/RELA/AKT1/IL6R/CASP3/CCL2/PRKCA/IL4/VEGFA/ERBB2/CAV1/ICAM1/IL1B/VCAM1/IL2RA/IFNG/PPARA/IGF2/CD40LG/IRF1/CD44,22
BP,GO:2000045,regulation of G1/S transition of mitotic cell cycle,16/160,184/18670,4.85E-12,1.94E-10,9.09E-11,CDK2/AKT1/CCND1/BCL2/CDKN1A/BAX/TP53/CCL2/EGFR/RB1/CYP1A1/CCNB1/CHEK2/E2F1/CDK4/MDM2,16
BP,GO:0010039,response to iron ion,9/160,33/18670,6.43E-12,2.55E-10,1.19E-10,CCND1/BCL2/SLC6A3/HIF1A/HMOX1/CYP1A1/CCNB1/MDM2/G6PD,9
BP,GO:0042136,neurotransmitter biosynthetic process,13/160,106/18670,6.58E-12,2.58E-10,1.21E-10,NOS2/PTGS2/AKT1/ACHE/SLC6A3/SLC6A4/CAV1/ICAM1/IL1B/NOS3/CYP1B1/IFNG/NQO1,13
BP,GO:0097756,negative regulation of blood vessel diameter,12/160,84/18670,6.87E-12,2.67E-10,1.25E-10,PTGS2/AKT1/CHRM3/SLC6A4/ADRA2A/ADRA2C/ADRA2B/EGFR/CAV1/GJA1/ICAM1/ECE1,12
BP,GO:0071356,cellular response to tumor necrosis factor,19/160,291/18670,7.25E-12,2.79E-10,1.31E-10,MAPK14/RELA/AKT1/CCL2/CXCL8/CASP8/MAPK1/NFKBIA/STAT1/ICAM1/VCAM1/COL1A1/GSTP1/NFE2L2/SLC2A4/CHUK/CD40LG/IKBKB/CASP1,19
BP,GO:0046683,response to organophosphorus,14/160,134/18670,9.14E-12,3.48E-10,1.63E-10,PTGS2/RELA/JUN/SLC6A3/SLC6A4/FOS/SOD1/STAT1/HSPA5/IL1B/THBD/COL1A1/APP/TYR,14
BP,GO:0048511,rhythmic process,19/160,295/18670,9.20E-12,3.48E-10,1.63E-10,NOS2/ESR1/PPARG/JUN/CASP3/TP53/PGR/SLC6A4/OPRM1/F7/EGFR/TOP1/HSPA5/NOS3/SERPINE1/CLDN4/PPARA/CDK4/MAPK8,19
BP,GO:0050727,regulation of inflammatory response,21/160,374/18670,9.41E-12,3.52E-10,1.65E-10,NOS2/ESR1/PPARG/PTGS2/MAPK14/RELA/MMP9/IL4/MMP3/EGFR/RB1/NFKBIA/SOD1/IL1B/SELE/IL2RA/SERPINE1/GSTP1/PPARA/PPARD/XIAP,21
BP,GO:0007596,blood coagulation,20/160,336/18670,1.06E-11,3.94E-10,1.84E-10,PRKCA/ADRA2A/PLAU/F7/ADRA2C/ADRA2B/MAPK1/RAF1/CAV1/F3/NOS3/HSPB1/PLAT/THBD/SERPINE1/COL1A1/NFE2L2/CD40LG/IRF1/HPSE,20
BP,GO:0044843,cell cycle G1/S phase transition,19/160,298/18670,1.10E-11,4.00E-10,1.87E-10,CDK2/AKT1/CCND1/BCL2/CDKN1A/BAX/TP53/CCL2/CCNA2/EGFR/RB1/MYC/CYP1A1/CCNB1/CHEK2/E2F1/CDK4/MDM2/PPP3CA,19
BP,GO:0090068,positive regulation of cell cycle process,19/160,298/18670,1.10E-11,4.00E-10,1.87E-10,CDK2/AKT1/CCND1/CDKN1A/BAX/TP53/EGFR/EGF/RB1/CYP1A1/IL1B/CCNB1/IL1A/CHEK2/E2F1/IGF2/CDK4/MDM2/APP,19
BP,GO:0007159,leukocyte cell-cell adhesion,20/160,337/18670,1.12E-11,4.04E-10,1.89E-10,DPP4/RELA/AKT1/IL6R/CASP3/CCL2/IL4/ERBB2/CAV1/ICAM1/IL1B/SELE/VCAM1/IL2RA/IFNG/PPARA/IGF2/CD40LG/IRF1/CD44,20
BP,GO:0001819,positive regulation of cytokine production,23/160,464/18670,1.13E-11,4.06E-10,1.90E-10,PTGS2/MAPK14/RELA/IL6R/CASP8/ADRA2A/IL4/SOD1/HIF1A/STAT1/HMOX1/IL1B/HSPB1/CYP1B1/SERPINE1/IFNG/IL1A/CHUK/CD40LG/IRF1/HPSE/APP/CASP1,23
BP,GO:1901342,regulation of vasculature development,22/160,422/18670,1.24E-11,4.41E-10,2.06E-10,PPARG/PTGS2/KDR/IL6R/CXCL8/PRKCA/VEGFA/HIF1A/STAT1/ERBB2/HMOX1/F3/IL1B/NOS3/HSPB1/CYP1B1/SERPINE1/IL1A/NFE2L2/CXCL10/E2F2/HK2,22
BP,GO:1904018,positive regulation of vasculature development,17/160,230/18670,1.39E-11,4.83E-10,2.26E-10,PTGS2/KDR/IL6R/CXCL8/PRKCA/VEGFA/HIF1A/HMOX1/F3/IL1B/NOS3/HSPB1/CYP1B1/SERPINE1/IL1A/NFE2L2/HK2,17
BP,GO:0007599,hemostasis,20/160,341/18670,1.39E-11,4.83E-10,2.26E-10,PRKCA/ADRA2A/PLAU/F7/ADRA2C/ADRA2B/MAPK1/RAF1/CAV1/F3/NOS3/HSPB1/PLAT/THBD/SERPINE1/COL1A1/NFE2L2/CD40LG/IRF1/HPSE,20
BP,GO:0050817,coagulation,20/160,342/18670,1.46E-11,5.04E-10,2.36E-10,PRKCA/ADRA2A/PLAU/F7/ADRA2C/ADRA2B/MAPK1/RAF1/CAV1/F3/NOS3/HSPB1/PLAT/THBD/SERPINE1/COL1A1/NFE2L2/CD40LG/IRF1/HPSE,20
BP,GO:0045765,regulation of angiogenesis,21/160,383/18670,1.47E-11,5.04E-10,2.36E-10,PPARG/PTGS2/KDR/CXCL8/PRKCA/VEGFA/HIF1A/STAT1/ERBB2/HMOX1/F3/IL1B/NOS3/HSPB1/CYP1B1/SERPINE1/IL1A/NFE2L2/CXCL10/E2F2/HK2,21
BP,GO:0048146,positive regulation of fibroblast proliferation,10/160,51/18670,1.52E-11,5.16E-10,2.42E-10,ESR1/CDKN1A/JUN/FN1/CCNA2/EGFR/MYC/CCNB1/E2F1/CDK4,10
BP,GO:1903037,regulation of leukocyte cell-cell adhesion,19/160,304/18670,1.55E-11,5.23E-10,2.45E-10,DPP4/RELA/AKT1/IL6R/CASP3/CCL2/IL4/ERBB2/CAV1/ICAM1/IL1B/VCAM1/IL2RA/IFNG/PPARA/IGF2/CD40LG/IRF1/CD44,19
BP,GO:0031668,cellular response to extracellular stimulus,18/160,268/18670,1.67E-11,5.58E-10,2.62E-10,PPARG/PTGS2/BCL2/CDKN1A/JUN/TP53/FOS/MAPK1/SOD1/HSPA5/HMOX1/ICAM1/VCAM1/COL1A1/GSTP1/NFE2L2/MDM2/MAPK8,18
BP,GO:0062013,positive regulation of small molecule metabolic process,14/160,141/18670,1.84E-11,6.07E-10,2.85E-10,NOS2/PPARG/PTGS2/AKT1/IL4/EGF/POR/HIF1A/IL1B/NOS3/IFNG/PPARA/IGF2/APP,14
BP,GO:0045787,positive regulation of cell cycle,21/160,389/18670,1.97E-11,6.47E-10,3.03E-10,CDK2/AKT1/CCND1/CDKN1A/BAX/TP53/SLC6A4/PRKCA/EGFR/EGF/RB1/CYP1A1/IL1B/CCNB1/IL1A/CHEK2/E2F1/IGF2/CDK4/MDM2/APP,21
BP,GO:1902806,regulation of cell cycle G1/S phase transition,16/160,202/18670,2.01E-11,6.54E-10,3.07E-10,CDK2/AKT1/CCND1/BCL2/CDKN1A/BAX/TP53/CCL2/EGFR/RB1/CYP1A1/CCNB1/CHEK2/E2F1/CDK4/MDM2,16
BP,GO:0030879,mammary gland development,14/160,143/18670,2.22E-11,7.18E-10,3.36E-10,ESR1/AR/AKT1/CCND1/BAX/PGR/SLC6A3/VEGFA/MAPK1/EGF/HIF1A/CAV1/GJA1/HK2,14
BP,GO:0045766,positive regulation of angiogenesis,16/160,204/18670,2.33E-11,7.48E-10,3.50E-10,PTGS2/KDR/CXCL8/PRKCA/VEGFA/HIF1A/HMOX1/F3/IL1B/NOS3/HSPB1/CYP1B1/SERPINE1/IL1A/NFE2L2/HK2,16
BP,GO:1901216,positive regulation of neuron death,12/160,94/18670,2.70E-11,8.57E-10,4.02E-10,BAX/CASP9/JUN/CASP3/TP53/MCL1/CASP8/FOS/IFNG/NQO1/PARP1/MAP2K4,12
BP,GO:0048871,multicellular organismal homeostasis,23/160,486/18670,2.88E-11,9.09E-10,4.26E-10,PTGS2/ADRB2/BCL2/BAX/ACHE/PRKCA/ADRB1/CA2/IL4/EGFR/VEGFA/RB1/SOD1/CAV1/GJA1/IL1B/NOS3/HSPB1/IL1A/CLDN4/SPP1/ADCY2/MET,23
BP,GO:0071456,cellular response to hypoxia,16/160,207/18670,2.91E-11,9.09E-10,4.26E-10,PTGS2/AKT1/BCL2/TP53/CCNA2/VEGFA/HIF1A/HMOX1/MYC/ICAM1/CCNB1/NFE2L2/SLC2A4/PPARD/E2F1/MDM2,16
BP,GO:0042542,response to hydrogen peroxide,14/160,146/18670,2.95E-11,9.09E-10,4.26E-10,RELA/BCL2/JUN/CASP3/SOD1/STAT1/HMOX1/CYP1B1/COL1A1/NFE2L2/NQO1/MDM2/MET/CAT,14
BP,GO:0051384,response to glucocorticoid,14/160,146/18670,2.95E-11,9.09E-10,4.26E-10,PTGS2/CCND1/BCL2/CDKN1A/CASP9/CASP3/EGFR/FOS/ICAM1/GSTP1/NR3C1/HSD3B2/HSD3B1/UGT1A1,14
BP,GO:0000082,G1/S transition of mitotic cell cycle,18/160,279/18670,3.26E-11,9.97E-10,4.67E-10,CDK2/AKT1/CCND1/BCL2/CDKN1A/BAX/TP53/CCL2/EGFR/RB1/MYC/CYP1A1/CCNB1/CHEK2/E2F1/CDK4/MDM2/PPP3CA,18
BP,GO:0045785,positive regulation of cell adhesion,21/160,403/18670,3.82E-11,1.16E-09,5.42E-10,DPP4/RELA/AKT1/KDR/IL6R/CCL2/FN1/PRKCA/IL4/VEGFA/ERBB2/CAV1/ICAM1/IL1B/VCAM1/IL2RA/IFNG/IGF2/CD40LG/CD44/PPP3CA,21
BP,GO:0048771,tissue remodeling,15/160,179/18670,3.94E-11,1.19E-09,5.56E-10,ADRB2/BAX/TP53/PRKCA/CA2/MMP2/EGFR/HIF1A/CAV1/GJA1/NOS3/IL1A/SPP1/MDM2/PPP3CA,15
BP,GO:0018108,peptidyl-tyrosine phosphorylation,20/160,363/18670,4.28E-11,1.28E-09,5.99E-10,KDR/IL6R/TP53/ADRA2A/IL4/EGFR/VEGFA/EGF/ERBB2/CAV1/ICAM1/IFNG/NCF1/INSRR/IGF2/ERBB3/CD44/APP/MET/MAP2K4,20
BP,GO:0050900,leukocyte migration,23/160,499/18670,4.89E-11,1.45E-09,6.79E-10,MAPK14/AKT1/IL6R/MMP1/CCL2/FN1/CXCL8/F7/VEGFA/HMOX1/CAV1/ICAM1/IL1B/SELE/VCAM1/THBD/SERPINE1/COL1A1/CXCL11/CXCL2/CXCL10/CD44/APP,23
BP,GO:0018212,peptidyl-tyrosine modification,20/160,366/18670,4.96E-11,1.46E-09,6.84E-10,KDR/IL6R/TP53/ADRA2A/IL4/EGFR/VEGFA/EGF/ERBB2/CAV1/ICAM1/IFNG/NCF1/INSRR/IGF2/ERBB3/CD44/APP/MET/MAP2K4,20
BP,GO:0001890,placenta development,14/160,152/18670,5.09E-11,1.49E-09,6.97E-10,PPARG/PTGS2/RXRA/MAPK14/AKT1/CASP8/EGFR/MAPK1/SOD1/HIF1A/GJA1/PPARD/SPP1/IGF2,14
BP,GO:2000134,negative regulation of G1/S transition of mitotic cell cycle,13/160,125/18670,5.50E-11,1.60E-09,7.48E-10,CDK2/CCND1/BCL2/CDKN1A/BAX/TP53/CCL2/RB1/CCNB1/CHEK2/E2F1/CDK4/MDM2,13
BP,GO:0036294,cellular response to decreased oxygen levels,16/160,217/18670,5.92E-11,1.70E-09,7.99E-10,PTGS2/AKT1/BCL2/TP53/CCNA2/VEGFA/HIF1A/HMOX1/MYC/ICAM1/CCNB1/NFE2L2/SLC2A4/PPARD/E2F1/MDM2,16
BP,GO:0030099,myeloid cell differentiation,21/160,416/18670,6.88E-11,1.97E-09,9.22E-10,PPARG/MAPK14/CASP9/JUN/CASP3/CASP8/PRKCA/CA2/MMP9/IL4/VEGFA/FOS/RB1/NFKBIA/HIF1A/STAT1/MYC/IFNG/PARP1/APP/G6PD,21
BP,GO:0030193,regulation of blood coagulation,11/160,79/18670,7.09E-11,2.00E-09,9.36E-10,PRKCA/PLAU/F7/CAV1/F3/NOS3/PLAT/THBD/SERPINE1/NFE2L2/HPSE,11
BP,GO:0071260,cellular response to mechanical stimulus,11/160,79/18670,7.09E-11,2.00E-09,9.36E-10,PTGS2/AKT1/CASP8/EGFR/GJA1/IL1B/COL1A1/IRF1/MAPK8/CASP1/MAP2K4,11
BP,GO:2000379,positive regulation of reactive oxygen species metabolic process,12/160,102/18670,7.19E-11,2.01E-09,9.44E-10,PTGS2/MAPK14/AKT1/CDKN1A/TP53/EGFR/SOD1/ICAM1/IL1B/IFNG/GSTP1/NFE2L2,12
BP,GO:0071902,positive regulation of protein serine/threonine kinase activity,19/160,334/18670,7.87E-11,2.19E-09,1.03E-09,MAPK14/ADRB2/AKT1/CCND1/ADRA2A/ADRA2B/EGFR/VEGFA/MAPK1/EGF/RAF1/SOD1/ERBB2/IL1B/CCNB1/IFNG/IGF2/CD40LG/MAP2K4,19
BP,GO:1900046,regulation of hemostasis,11/160,80/18670,8.16E-11,2.25E-09,1.06E-09,PRKCA/PLAU/F7/CAV1/F3/NOS3/PLAT/THBD/SERPINE1/NFE2L2/HPSE,11
BP,GO:0008631,intrinsic apoptotic signaling pathway in response to oxidative stress,9/160,43/18670,8.74E-11,2.40E-09,1.12E-09,AKT1/BCL2/MCL1/SOD1/HIF1A/HSPB1/CYP1B1/NFE2L2/PARP1,9
BP,GO:1902807,negative regulation of cell cycle G1/S phase transition,13/160,131/18670,9.99E-11,2.72E-09,1.27E-09,CDK2/CCND1/BCL2/CDKN1A/BAX/TP53/CCL2/RB1/CCNB1/CHEK2/E2F1/CDK4/MDM2,13
BP,GO:0052548,regulation of endopeptidase activity,21/160,425/18670,1.02E-10,2.76E-09,1.29E-09,PPARG/PTGS2/AKT1/BAX/CASP9/CASP8/MMP9/VEGFA/POR/RAF1/MYC/F3/BIRC5/SERPINE1/CTSD/CD44/MDM2/APP/XIAP/SLPI/CASP1,21
BP,GO:0046209,nitric oxide metabolic process,11/160,82/18670,1.07E-10,2.89E-09,1.35E-09,NOS2/PTGS2/AKT1/POR/CAV1/ICAM1/IL1B/NOS3/CYP1B1/IFNG/NQO1,11
BP,GO:0062012,regulation of small molecule metabolic process,21/160,429/18670,1.21E-10,3.24E-09,1.52E-09,NOS2/PPARG/PTGS2/AKT1/TP53/IL4/EGF/POR/ODC1/SOD1/HIF1A/CAV1/IL1B/NOS3/IFNG/NQO1/PARP1/PPARA/IGFBP3/IGF2/APP,21
BP,GO:0045931,positive regulation of mitotic cell cycle,14/160,163/18670,1.30E-10,3.46E-09,1.62E-09,AKT1/CCND1/PRKCA/EGFR/EGF/RB1/CYP1A1/IL1B/CCNB1/IL1A/IGF2/CDK4/MDM2/APP,14
BP,GO:0050818,regulation of coagulation,11/160,84/18670,1.40E-10,3.70E-09,1.73E-09,PRKCA/PLAU/F7/CAV1/F3/NOS3/PLAT/THBD/SERPINE1/NFE2L2/HPSE,11
BP,GO:0002526,acute inflammatory response,12/160,108/18670,1.42E-10,3.72E-09,1.74E-09,PPARG/PTGS2/IL6R/FN1/OPRM1/F3/ICAM1/IL1B/VCAM1/IL1A/GSTP1/UGT1A1,12
BP,GO:2001057,reactive nitrogen species metabolic process,11/160,85/18670,1.60E-10,4.16E-09,1.95E-09,NOS2/PTGS2/AKT1/POR/CAV1/ICAM1/IL1B/NOS3/CYP1B1/IFNG/NQO1,11
BP,GO:0060135,maternal process involved in female pregnancy,10/160,64/18670,1.64E-10,4.23E-09,1.98E-09,ESR1/AR/PTGS2/RXRA/AKT1/PGR/MAPK1/GJA1/PPARD/SPP1,10
BP,GO:0042445,hormone metabolic process,16/160,233/18670,1.71E-10,4.39E-09,2.06E-09,ESR1/ACHE/CYP3A4/CYP1A2/POR/HIF1A/CYP1A1/IL1B/SULT1E1/CYP1B1/IFNG/SPP1/HSD3B2/HSD3B1/ECE1/UGT1A1,16
BP,GO:0010631,epithelial cell migration,19/160,352/18670,1.92E-10,4.90E-09,2.29E-09,PPARG/PTGS2/DPP4/AKT1/KDR/JUN/PRKCA/MMP9/IL4/VEGFA/HIF1A/HMOX1/NOS3/HSPB1/CYP1B1/IFNG/NFE2L2/PPARD/MET,19
BP,GO:0051222,positive regulation of protein transport,21/160,440/18670,1.93E-10,4.90E-09,2.29E-09,PTGS2/MAPK14/BCL2/TP53/CHRM1/ACHE/CASP8/EGFR/MAPK1/HIF1A/ERBB2/GJA1/IL1B/IFNG/IL1A/PPARD/CHUK/E2F1/MDM2/MAPK8/CASP1,21
BP,GO:1904019,epithelial cell apoptotic process,12/160,111/18670,1.97E-10,4.95E-09,2.32E-09,KDR/CCL2/IL4/BCL2L1/RB1/HMOX1/ICAM1/SERPINE1/NFE2L2/E2F1/E2F2/CD40LG,12
BP,GO:0061614,pri-miRNA transcription by RNA polymerase II,9/160,47/18670,2.05E-10,5.13E-09,2.40E-09,PPARG/RELA/JUN/TP53/FOS/HIF1A/PPARA/PPARD/NR3C1,9
BP,GO:0051100,negative regulation of binding,14/160,169/18670,2.11E-10,5.26E-09,2.46E-09,ADRB2/AKT1/BAX/JUN/NFKBIA/HSPA5/HMOX1/CAV1/PPARA/E2F1/MET/MAPK8/PPP3CA/SLPI,14
BP,GO:0045907,positive regulation of vasoconstriction,8/160,32/18670,2.16E-10,5.33E-09,2.50E-09,PTGS2/AKT1/CHRM3/ADRA2C/EGFR/CAV1/GJA1/ICAM1,8
BP,GO:0043279,response to alkaloid,12/160,112/18670,2.19E-10,5.37E-09,2.51E-09,PPARG/RELA/CASP3/SLC6A3/OPRM1/CCNA2/HTR3A/BCL2L1/HSPA5/ICAM1/MDM2/CASP7,12
BP,GO:0007050,cell cycle arrest,16/160,237/18670,2.20E-10,5.37E-09,2.52E-09,CDK2/CCND1/CDKN1A/BAX/TP53/CXCL8/RB1/MYC/CCNB1/IFNG/CHEK2/RASSF1/E2F1/IRF1/CDK4/MDM2,16
BP,GO:0090132,epithelium migration,19/160,355/18670,2.22E-10,5.39E-09,2.52E-09,PPARG/PTGS2/DPP4/AKT1/KDR/JUN/PRKCA/MMP9/IL4/VEGFA/HIF1A/HMOX1/NOS3/HSPB1/CYP1B1/IFNG/NFE2L2/PPARD/MET,19
BP,GO:0010634,positive regulation of epithelial cell migration,14/160,171/18670,2.47E-10,5.96E-09,2.79E-09,PTGS2/AKT1/KDR/JUN/PRKCA/MMP9/VEGFA/HIF1A/HMOX1/NOS3/HSPB1/IFNG/NFE2L2/MET,14
BP,GO:0002573,myeloid leukocyte differentiation,15/160,204/18670,2.51E-10,5.99E-09,2.81E-09,PPARG/MAPK14/JUN/CASP8/PRKCA/CA2/MMP9/IL4/VEGFA/FOS/RB1/MYC/IFNG/PARP1/APP,15
BP,GO:0035265,organ growth,15/160,204/18670,2.51E-10,5.99E-09,2.81E-09,ESR1/AR/RXRA/MAPK14/AKT1/BCL2/SLC6A4/MAPK1/POR/SOD1/GJA1/CCNB1/PPARA/G6PD/MAP2K4,15
BP,GO:0045862,positive regulation of proteolysis,19/160,358/18670,2.56E-10,6.06E-09,2.84E-09,PPARG/MAPK14/AKT1/BAX/CASP9/FN1/CASP8/ADRA2A/EGF/CAV1/MYC/F3/IL1B/IFNG/NFE2L2/CTSD/MDM2/APP/CASP1,19
BP,GO:0030522,intracellular receptor signaling pathway,17/160,278/18670,2.73E-10,6.42E-09,3.01E-09,ESR1/AR/PPARG/RXRA/RELA/PGR/CASP8/ESR2/RB1/NFKBIA/NR1I2/PARP1/NR1I3/PPARA/PPARD/NR3C1/XIAP,17
BP,GO:0090130,tissue migration,19/160,361/18670,2.95E-10,6.90E-09,3.23E-09,PPARG/PTGS2/DPP4/AKT1/KDR/JUN/PRKCA/MMP9/IL4/VEGFA/HIF1A/HMOX1/NOS3/HSPB1/CYP1B1/IFNG/NFE2L2/PPARD/MET,19
BP,GO:0055093,response to hyperoxia,7/160,21/18670,3.13E-10,7.28E-09,3.41E-09,PPARG/CDKN1A/CAV1/CYP1A1/COL1A1/CDK4/CAT,7
BP,GO:0009266,response to temperature stimulus,16/160,243/18670,3.18E-10,7.36E-09,3.45E-09,PPARG/PTGS2/ADRB2/AKT1/CDKN1A/CASP8/ADRB1/FOS/MAPK1/NFKBIA/SOD1/HSPA5/HMOX1/NOS3/IL1A/CXCL10,16
BP,GO:0071375,cellular response to peptide hormone stimulus,18/160,321/18670,3.23E-10,7.43E-09,3.48E-09,PPARG/RELA/AKT1/CCNA2/CA2/POR/STAT1/CAV1/IL1B/GSTP1/NFE2L2/PARP1/SLC2A4/INSRR/IGF2/CDK4/MDM2/ADCY2,18
BP,GO:2000273,positive regulation of signaling receptor activity,8/160,34/18670,3.67E-10,8.39E-09,3.93E-09,ADRB2/CCL2/ADRA2A/ADRA2C/ADRA2B/EGF/IFNG/NCF1,8
BP,GO:1904951,positive regulation of establishment of protein localization,21/160,456/18670,3.71E-10,8.43E-09,3.95E-09,PTGS2/MAPK14/BCL2/TP53/CHRM1/ACHE/CASP8/EGFR/MAPK1/HIF1A/ERBB2/GJA1/IL1B/IFNG/IL1A/PPARD/CHUK/E2F1/MDM2/MAPK8/CASP1,21
BP,GO:0036473,cell death in response to oxidative stress,11/160,93/18670,4.31E-10,9.75E-09,4.57E-09,AKT1/BCL2/MCL1/MMP3/SOD1/HIF1A/HSPB1/CYP1B1/NFE2L2/PARP1/MET,11
BP,GO:0038034,signal transduction in absence of ligand,10/160,72/18670,5.47E-10,1.22E-08,5.73E-09,AKT1/BCL2/BAX/CASP9/CASP3/MCL1/BCL2L1/IL1B/IL1A/ERBB3,10
BP,GO:0097192,extrinsic apoptotic signaling pathway in absence of ligand,10/160,72/18670,5.47E-10,1.22E-08,5.73E-09,AKT1/BCL2/BAX/CASP9/CASP3/MCL1/BCL2L1/IL1B/IL1A/ERBB3,10
BP,GO:0008217,regulation of blood pressure,14/160,182/18670,5.65E-10,1.26E-08,5.88E-09,NOS2/PTGS1/AR/PPARG/PTGS2/ADRB2/ADRB1/ADRA2B/SOD1/HMOX1/GJA1/NOS3/PPARA/ECE1,14
BP,GO:0032147,activation of protein kinase activity,18/160,333/18670,5.83E-10,1.29E-08,6.04E-09,MAPK14/ADRB2/AKT1/IL6R/ADRA2A/IL4/ADRA2C/ADRA2B/EGFR/VEGFA/MAPK1/EGF/RAF1/SOD1/IL1B/CD40LG/ADCY2/MAP2K4,18
BP,GO:0008585,female gonad development,11/160,96/18670,6.10E-10,1.34E-08,6.29E-09,ESR1/BCL2/BAX/CASP3/PGR/VEGFA/BCL2L1/SOD1/HSPA5/ICAM1/NOS3,11
BP,GO:0031100,animal organ regeneration,10/160,73/18670,6.29E-10,1.38E-08,6.45E-09,PPARG/CCND1/CDKN1A/F7/CCNA2/EGFR/HMOX1/GSTP1/CDK4/UGT1A1,10
BP,GO:1903039,positive regulation of leukocyte cell-cell adhesion,15/160,218/18670,6.36E-10,1.38E-08,6.48E-09,DPP4/RELA/AKT1/IL6R/CCL2/IL4/CAV1/ICAM1/IL1B/VCAM1/IL2RA/IFNG/IGF2/CD40LG/CD44,15
BP,GO:2001243,negative regulation of intrinsic apoptotic signaling pathway,11/160,98/18670,7.64E-10,1.65E-08,7.75E-09,PTGS2/AKT1/BCL2/MCL1/MMP9/BCL2L1/HIF1A/HSPB1/NFE2L2/CD44/MDM2,11
BP,GO:0006805,xenobiotic metabolic process,12/160,125/18670,7.92E-10,1.70E-08,7.99E-09,PTGS1/CYP3A4/CYP1A2/CYP2B6/POR/CYP1A1/NR1I2/CYP1B1/GSTP1/NQO1/GSTM1/UGT1A1,12
BP,GO:0051091,positive regulation of DNA-binding transcription factor activity,16/160,261/18670,9.07E-10,1.94E-08,9.09E-09,ESR1/AR/PPARG/RELA/AKT1/ESR2/VEGFA/CAV1/ICAM1/IL1B/CHUK/CD40LG/APP/IKBKB/PPP3CA/CAT,16
BP,GO:0046545,development of primary female sexual characteristics,11/160,101/18670,1.06E-09,2.26E-08,1.06E-08,ESR1/BCL2/BAX/CASP3/PGR/VEGFA/BCL2L1/SOD1/HSPA5/ICAM1/NOS3,11
BP,GO:0006809,nitric oxide biosynthetic process,10/160,77/18670,1.08E-09,2.29E-08,1.07E-08,NOS2/PTGS2/AKT1/CAV1/ICAM1/IL1B/NOS3/CYP1B1/IFNG/NQO1,10
BP,GO:0019932,second-messenger-mediated signaling,20/160,439/18670,1.21E-09,2.55E-08,1.20E-08,NOS2/ADRB2/KDR/CXCL8/OPRM1/PRKCA/ADRA2A/ADRB1/ADRA2C/ADRA2B/EGFR/VEGFA/SELE/VCAM1/NOS3/CXCL11/CXCL10/ERBB3/ADCY2/PPP3CA,20
BP,GO:0043536,positive regulation of blood vessel endothelial cell migration,10/160,79/18670,1.40E-09,2.93E-08,1.37E-08,PTGS2/AKT1/KDR/PRKCA/VEGFA/HIF1A/HMOX1/NOS3/HSPB1/NFE2L2,10
BP,GO:0008630,intrinsic apoptotic signaling pathway in response to DNA damage,11/160,104/18670,1.46E-09,3.03E-08,1.42E-08,BCL2/CDKN1A/BAX/CASP9/TP53/MCL1/BCL2L1/HMOX1/CHEK2/E2F1/CD44,11
BP,GO:0034349,glial cell apoptotic process,6/160,15/18670,1.69E-09,3.51E-08,1.65E-08,CASP9/CASP3/TP53/CCL2/PRKCA/RB1,6
BP,GO:1902893,regulation of pri-miRNA transcription by RNA polymerase II,8/160,41/18670,1.83E-09,3.78E-08,1.77E-08,RELA/JUN/TP53/FOS/HIF1A/PPARA/PPARD/NR3C1,8
BP,GO:0031669,cellular response to nutrient levels,15/160,237/18670,2.02E-09,4.14E-08,1.94E-08,PPARG/PTGS2/BCL2/CDKN1A/JUN/TP53/MAPK1/SOD1/HSPA5/HMOX1/ICAM1/COL1A1/NFE2L2/MDM2/MAPK8,15
BP,GO:1902175,regulation of oxidative stress-induced intrinsic apoptotic signaling pathway,7/160,27/18670,2.29E-09,4.67E-08,2.19E-08,AKT1/MCL1/SOD1/HIF1A/HSPB1/NFE2L2/PARP1,7
BP,GO:0010469,regulation of signaling receptor activity,13/160,169/18670,2.39E-09,4.85E-08,2.27E-08,ADRB2/CCL2/OPRM1/ADRA2A/PLAU/ESR2/ADRA2C/ADRA2B/EGF/SERPINE1/IFNG/NCF1/APP,13
BP,GO:0001676,long-chain fatty acid metabolic process,11/160,109/18670,2.41E-09,4.88E-08,2.29E-08,PTGS1/PTGS2/LTA4H/CYP3A4/CYP1A2/CYP2B6/CYP1A1/CYP1B1/ALOX5/GSTP1/ACOX1,11
BP,GO:0043154,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process,10/160,84/18670,2.58E-09,5.19E-08,2.43E-08,PTGS2/AKT1/MMP9/VEGFA/POR/RAF1/BIRC5/CD44/MDM2/XIAP,10
BP,GO:1903829,positive regulation of cellular protein localization,17/160,324/18670,2.83E-09,5.66E-08,2.65E-08,PTGS2/MAPK14/AKT1/BCL2/TP53/CHRM1/CASP8/EGFR/MAPK1/EGF/ERBB2/IL1B/IFNG/PARP1/E2F1/MDM2/MAPK8,17
BP,GO:0050679,positive regulation of epithelial cell proliferation,14/160,206/18670,2.85E-09,5.68E-08,2.66E-08,AR/SCN5A/AKT1/CCND1/KDR/JUN/PRKCA/EGFR/VEGFA/HIF1A/ERBB2/HMOX1/MYC/F3,14
BP,GO:0001667,ameboidal-type cell migration,20/160,462/18670,2.91E-09,5.77E-08,2.70E-08,PPARG/PTGS2/DPP4/AKT1/KDR/JUN/FN1/PRKCA/MMP9/IL4/VEGFA/HIF1A/HMOX1/NOS3/HSPB1/CYP1B1/IFNG/NFE2L2/PPARD/MET,20
BP,GO:0042737,drug catabolic process,12/160,140/18670,2.94E-09,5.79E-08,2.71E-08,ACHE/SLC6A3/MAOA/CYP3A4/CYP1A2/CYP2B6/POR/SULT1E1/NR1I2/MPO/ECE1/CAT,12
BP,GO:0036296,response to increased oxygen levels,7/160,28/18670,3.03E-09,5.94E-08,2.79E-08,PPARG/CDKN1A/CAV1/CYP1A1/COL1A1/CDK4/CAT,7
BP,GO:0031571,mitotic G1 DNA damage checkpoint,9/160,63/18670,3.17E-09,6.16E-08,2.89E-08,CDK2/CCND1/CDKN1A/BAX/TP53/CCNB1/CHEK2/E2F1/MDM2,9
BP,GO:0044819,mitotic G1/S transition checkpoint,9/160,63/18670,3.17E-09,6.16E-08,2.89E-08,CDK2/CCND1/CDKN1A/BAX/TP53/CCNB1/CHEK2/E2F1/MDM2,9
BP,GO:1990748,cellular detoxification,11/160,112/18670,3.23E-09,6.25E-08,2.93E-08,PTGS1/PTGS2/SOD1/NOS3/MPO/ABCG2/GSTP1/NFE2L2/NQO1/GSTM1/CAT,11
BP,GO:0044783,G1 DNA damage checkpoint,9/160,64/18670,3.66E-09,7.05E-08,3.30E-08,CDK2/CCND1/CDKN1A/BAX/TP53/CCNB1/CHEK2/E2F1/MDM2,9
BP,GO:0006690,icosanoid metabolic process,11/160,114/18670,3.90E-09,7.43E-08,3.48E-08,PTGS1/PTGS2/PON1/LTA4H/CYP1A2/CYP2B6/CYP1A1/IL1B/CYP1B1/ALOX5/ACOX1,11
BP,GO:0001936,regulation of endothelial cell proliferation,13/160,176/18670,3.92E-09,7.43E-08,3.48E-08,PPARG/AKT1/KDR/JUN/CCL2/PRKCA/VEGFA/HIF1A/STAT1/HMOX1/CAV1/F3/GJA1,13
BP,GO:0090316,positive regulation of intracellular protein transport,13/160,176/18670,3.92E-09,7.43E-08,3.48E-08,PTGS2/MAPK14/BCL2/TP53/CHRM1/CASP8/MAPK1/ERBB2/IL1B/IFNG/E2F1/MDM2/MAPK8,13
BP,GO:0003012,muscle system process,20/160,472/18670,4.19E-09,7.88E-08,3.69E-08,SCN5A/PTGS2/ADRB2/CHRM3/PRKCA/ADRA2A/ADRA2C/ADRA2B/SOD1/HMOX1/CAV1/GJA1/IL1B/NOS3/PARP1/PPARA/CHUK/G6PD/PPP3CA/MAP2K4,20
BP,GO:0050708,regulation of protein secretion,20/160,472/18670,4.19E-09,7.88E-08,3.69E-08,NOS2/DPP4/MAPK14/FN1/ACHE/OPRM1/PRKCA/ADRA2A/ADRA2C/EGFR/HIF1A/GJA1/IL1B/IFNG/IL1A/PPARD/CHUK/CD40LG/PPP3CA/CASP1,20
BP,GO:0046660,female sex differentiation,11/160,115/18670,4.28E-09,8.01E-08,3.75E-08,ESR1/BCL2/BAX/CASP3/PGR/VEGFA/BCL2L1/SOD1/HSPA5/ICAM1/NOS3,11
BP,GO:0010632,regulation of epithelial cell migration,16/160,291/18670,4.36E-09,8.11E-08,3.80E-08,PPARG/PTGS2/AKT1/KDR/JUN/PRKCA/MMP9/IL4/VEGFA/HIF1A/HMOX1/NOS3/HSPB1/IFNG/NFE2L2/MET,16
BP,GO:0022409,positive regulation of cell-cell adhesion,15/160,255/18670,5.47E-09,1.01E-07,4.75E-08,DPP4/RELA/AKT1/IL6R/CCL2/IL4/CAV1/ICAM1/IL1B/VCAM1/IL2RA/IFNG/IGF2/CD40LG/CD44,15
BP,GO:0008406,gonad development,14/160,217/18670,5.57E-09,1.03E-07,4.82E-08,ESR1/AR/CCND1/BCL2/BAX/CASP3/PGR/VEGFA/BCL2L1/SOD1/HSPA5/GJA1/ICAM1/NOS3,14
BP,GO:0045639,positive regulation of myeloid cell differentiation,10/160,91/18670,5.71E-09,1.05E-07,4.91E-08,MAPK14/JUN/CASP8/PRKCA/CA2/FOS/RB1/HIF1A/STAT1/IFNG,10
BP,GO:0050730,regulation of peptidyl-tyrosine phosphorylation,15/160,256/18670,5.77E-09,1.05E-07,4.94E-08,IL6R/TP53/ADRA2A/IL4/EGFR/VEGFA/EGF/CAV1/ICAM1/IFNG/NCF1/IGF2/ERBB3/CD44/APP,15
BP,GO:0043401,steroid hormone mediated signaling pathway,13/160,182/18670,5.88E-09,1.07E-07,5.02E-08,ESR1/AR/PPARG/RXRA/PGR/ESR2/RB1/NR1I2/PARP1/NR1I3/PPARA/PPARD/NR3C1,13
BP,GO:0070661,leukocyte proliferation,16/160,298/18670,6.12E-09,1.10E-07,5.15E-08,BCL2/CDKN1A/BAX/IL6R/CASP3/TP53/IL4/ERBB2/GJA1/IL1B/VCAM1/IL2RA/GSTP1/IGF2/CD40LG/IRF1,16
BP,GO:0035994,response to muscle stretch,6/160,18/18670,6.15E-09,1.10E-07,5.15E-08,MAPK14/RELA/JUN/FOS/NFKBIA/RAF1,6
BP,GO:0060749,mammary gland alveolus development,6/160,18/18670,6.15E-09,1.10E-07,5.15E-08,ESR1/AR/CCND1/VEGFA/EGF/HIF1A,6
BP,GO:0061377,mammary gland lobule development,6/160,18/18670,6.15E-09,1.10E-07,5.15E-08,ESR1/AR/CCND1/VEGFA/EGF/HIF1A,6
BP,GO:2000117,negative regulation of cysteine-type endopeptidase activity,10/160,92/18670,6.35E-09,1.13E-07,5.30E-08,PTGS2/AKT1/MMP9/VEGFA/POR/RAF1/BIRC5/CD44/MDM2/XIAP,10
BP,GO:0042098,T cell proliferation,13/160,184/18670,6.72E-09,1.19E-07,5.58E-08,BAX/IL6R/CASP3/TP53/IL4/ERBB2/GJA1/IL1B/VCAM1/IL2RA/IGF2/CD40LG/IRF1,13
BP,GO:0090257,regulation of muscle system process,15/160,259/18670,6.76E-09,1.19E-07,5.58E-08,SCN5A/PTGS2/ADRB2/CHRM3/PRKCA/ADRA2A/ADRA2C/ADRA2B/SOD1/CAV1/NOS3/PARP1/PPARA/G6PD/PPP3CA,15
BP,GO:1901655,cellular response to ketone,10/160,93/18670,7.07E-09,1.24E-07,5.82E-08,AR/PPARG/AKT1/CASP9/EGFR/ICAM1/SPP1/NR3C1/CDK4/ADCY2,10
BP,GO:0045137,development of primary sexual characteristics,14/160,223/18670,7.91E-09,1.38E-07,6.48E-08,ESR1/AR/CCND1/BCL2/BAX/CASP3/PGR/VEGFA/BCL2L1/SOD1/HSPA5/GJA1/ICAM1/NOS3,14
BP,GO:0060326,cell chemotaxis,16/160,304/18670,8.12E-09,1.41E-07,6.62E-08,MAPK14/KDR/IL6R/CCL2/CXCL8/F7/VEGFA/IL1B/VCAM1/HSPB1/SERPINE1/GSTP1/CXCL11/CXCL2/CXCL10/MET,16
BP,GO:0035094,response to nicotine,8/160,49/18670,8.17E-09,1.42E-07,6.63E-08,RELA/BCL2/CASP3/SLC6A3/MAPK1/HMOX1/VCAM1/PPARA,8
BP,GO:0008210,estrogen metabolic process,7/160,32/18670,8.37E-09,1.44E-07,6.76E-08,CYP3A4/CYP1A2/CYP1A1/SULT1E1/CYP1B1/HSD3B1/UGT1A1,7
BP,GO:0008637,apoptotic mitochondrial changes,11/160,124/18670,9.53E-09,1.63E-07,7.64E-08,AKT1/BCL2/BAX/JUN/TP53/CASP8/MMP9/BCL2L1/E2F1/HK2/MAPK8,11
BP,GO:0051101,regulation of DNA binding,11/160,124/18670,9.53E-09,1.63E-07,7.64E-08,PPARG/JUN/MMP9/EGF/RB1/NFKBIA/HMOX1/IFNG/PARP1/E2F1/MAPK8,11
BP,GO:0001503,ossification,18/160,398/18670,9.70E-09,1.65E-07,7.74E-08,PTGS2/MAPK14/ADRB2/AKT1/BCL2/IL6R/ACHE/MMP2/EGFR/MAPK1/HIF1A/GJA1/COL1A1/SPP1/RUNX2/IGFBP3/IGF2/CAT,18
BP,GO:0032102,negative regulation of response to external stimulus,18/160,400/18670,1.05E-08,1.78E-07,8.33E-08,PPARG/CDKN1A/CCL2/SLC6A3/PLAU/IL4/RB1/SOD1/GJA1/NOS3/IL2RA/PLAT/THBD/SERPINE1/GSTP1/PPARA/PPARD/SPP1,18
BP,GO:0001935,endothelial cell proliferation,13/160,191/18670,1.05E-08,1.78E-07,8.34E-08,PPARG/AKT1/KDR/JUN/CCL2/PRKCA/VEGFA/HIF1A/STAT1/HMOX1/CAV1/F3/GJA1,13
BP,GO:0051591,response to cAMP,10/160,97/18670,1.07E-08,1.80E-07,8.42E-08,RELA/JUN/SLC6A3/FOS/STAT1/HSPA5/THBD/COL1A1/APP/TYR,10
BP,GO:0002791,regulation of peptide secretion,20/160,500/18670,1.11E-08,1.86E-07,8.69E-08,NOS2/DPP4/MAPK14/FN1/ACHE/OPRM1/PRKCA/ADRA2A/ADRA2C/EGFR/HIF1A/GJA1/IL1B/IFNG/IL1A/PPARD/CHUK/CD40LG/PPP3CA/CASP1,20
BP,GO:0007566,embryo implantation,8/160,51/18670,1.14E-08,1.90E-07,8.88E-08,PTGS2/RXRA/MMP2/MMP9/SOD1/IL1B/PPARD/SPP1,8
BP,GO:0006801,superoxide metabolic process,9/160,73/18670,1.21E-08,1.99E-07,9.33E-08,NOS2/EGFR/SOD1/NOS3/MPO/NCF1/GSTP1/NFE2L2/NQO1,9
BP,GO:0043627,response to estrogen,9/160,73/18670,1.21E-08,1.99E-07,9.33E-08,ESR1/PPARG/CCND1/F7/CA2/MAPK1/HMOX1/CAV1/MDM2,9
BP,GO:1903524,positive regulation of blood circulation,9/160,73/18670,1.21E-08,1.99E-07,9.33E-08,PTGS2/AKT1/CHRM3/ADRB1/ADRA2C/EGFR/CAV1/GJA1/ICAM1,9
BP,GO:0051767,nitric-oxide synthase biosynthetic process,6/160,20/18670,1.27E-08,2.07E-07,9.69E-08,KDR/CCL2/STAT1/IFNG/GSTP1/MAP2K4,6
BP,GO:0051769,regulation of nitric-oxide synthase biosynthetic process,6/160,20/18670,1.27E-08,2.07E-07,9.69E-08,KDR/CCL2/STAT1/IFNG/GSTP1/MAP2K4,6
BP,GO:0050863,regulation of T cell activation,16/160,314/18670,1.28E-08,2.09E-07,9.78E-08,DPP4/AKT1/IL6R/CASP3/CCL2/IL4/SOD1/ERBB2/CAV1/IL1B/VCAM1/IL2RA/IFNG/IGF2/CD40LG/IRF1,16
BP,GO:0046651,lymphocyte proliferation,15/160,272/18670,1.31E-08,2.12E-07,9.92E-08,BCL2/CDKN1A/BAX/IL6R/CASP3/TP53/IL4/ERBB2/GJA1/IL1B/VCAM1/IL2RA/IGF2/CD40LG/IRF1,15
BP,GO:0010595,positive regulation of endothelial cell migration,11/160,128/18670,1.33E-08,2.15E-07,1.01E-07,PTGS2/AKT1/KDR/PRKCA/VEGFA/HIF1A/HMOX1/NOS3/HSPB1/NFE2L2/MET,11
BP,GO:0032943,mononuclear cell proliferation,15/160,274/18670,1.44E-08,2.31E-07,1.08E-07,BCL2/CDKN1A/BAX/IL6R/CASP3/TP53/IL4/ERBB2/GJA1/IL1B/VCAM1/IL2RA/IGF2/CD40LG/IRF1,15
BP,GO:0034754,cellular hormone metabolic process,11/160,129/18670,1.45E-08,2.31E-07,1.08E-07,ESR1/CYP3A4/CYP1A2/CYP1A1/SULT1E1/CYP1B1/SPP1/HSD3B2/HSD3B1/ECE1/UGT1A1,11
BP,GO:0070371,ERK1 and ERK2 cascade,16/160,317/18670,1.47E-08,2.34E-07,1.10E-07,KDR/JUN/CCL2/FN1/OPRM1/PRKCA/EGFR/MAPK1/EGF/ERBB2/MYC/ICAM1/IL1B/GSTP1/CD44/APP,16
BP,GO:0031331,positive regulation of cellular catabolic process,17/160,362/18670,1.48E-08,2.34E-07,1.10E-07,ADRB2/AKT1/BAX/KDR/ADRA2A/IL4/EGF/HIF1A/HMOX1/CAV1/IL1B/IFNG/NFE2L2/PPARA/HK2/MDM2/APP,17
BP,GO:0043270,positive regulation of ion transport,15/160,275/18670,1.51E-08,2.39E-07,1.12E-07,SCN5A/ADRB2/AKT1/BAX/CCL2/CHRM1/SLC6A4/ADRA2A/HTR3A/CAV1/IL1B/IFNG/CXCL11/CXCL10/G6PD,15
BP,GO:0150076,neuroinflammatory response,9/160,75/18670,1.54E-08,2.42E-07,1.13E-07,PTGS2/JUN/MMP9/IL4/MMP3/EGFR/IL1B/IFNG/APP,9
BP,GO:1903201,regulation of oxidative stress-induced cell death,9/160,75/18670,1.54E-08,2.42E-07,1.13E-07,AKT1/MCL1/MMP3/SOD1/HIF1A/HSPB1/NFE2L2/PARP1/MET,9
BP,GO:0048661,positive regulation of smooth muscle cell proliferation,10/160,101/18670,1.59E-08,2.48E-07,1.16E-07,PTGS2/AKT1/JUN/IL6R/MMP2/MMP9/EGFR/STAT1/HMOX1/MDM2,10
BP,GO:0001893,maternal placenta development,7/160,35/18670,1.64E-08,2.54E-07,1.19E-07,PTGS2/RXRA/AKT1/MAPK1/GJA1/PPARD/SPP1,7
BP,GO:0071312,cellular response to alkaloid,7/160,35/18670,1.64E-08,2.54E-07,1.19E-07,CASP3/OPRM1/CCNA2/BCL2L1/ICAM1/MDM2/CASP7,7
BP,GO:1904645,response to amyloid-beta,8/160,54/18670,1.82E-08,2.81E-07,1.32E-07,ADRB2/MMP2/MMP9/MMP3/ICAM1/VCAM1/PARP1/APP,8
BP,GO:0030198,extracellular matrix organization,17/160,368/18670,1.88E-08,2.89E-07,1.36E-07,DPP4/PRSS1/KDR/MMP1/FN1/MMP2/MMP9/MMP3/RB1/ICAM1/VCAM1/CYP1B1/SERPINE1/COL1A1/SPP1/CD44/APP,17
BP,GO:0043062,extracellular structure organization,17/160,369/18670,1.95E-08,3.00E-07,1.40E-07,DPP4/PRSS1/KDR/MMP1/FN1/MMP2/MMP9/MMP3/RB1/ICAM1/VCAM1/CYP1B1/SERPINE1/COL1A1/SPP1/CD44/APP,17
BP,GO:0042770,signal transduction in response to DNA damage,11/160,133/18670,1.99E-08,3.04E-07,1.42E-07,MAPK14/CDK2/CDKN1A/BAX/CASP9/TP53/CCNB1/CHEK2/E2F1/CD44/MDM2,11
BP,GO:0072332,intrinsic apoptotic signaling pathway by p53 class mediator,9/160,78/18670,2.19E-08,3.33E-07,1.56E-07,BCL2/CDKN1A/BAX/TP53/CHEK2/E2F1/E2F2/CD44/MDM2,9
BP,GO:0033138,positive regulation of peptidyl-serine phosphorylation,10/160,105/18670,2.31E-08,3.50E-07,1.64E-07,PTGS2/AKT1/BCL2/EGFR/VEGFA/RAF1/CAV1/IFNG/CD44/APP,10
BP,GO:0050921,positive regulation of chemotaxis,11/160,135/18670,2.33E-08,3.51E-07,1.65E-07,MAPK14/KDR/IL6R/CXCL8/F7/VEGFA/F3/HSPB1/SERPINE1/CXCL10/MET,11
BP,GO:0010506,regulation of autophagy,16/160,328/18670,2.37E-08,3.56E-07,1.67E-07,ADRB2/AKT1/BCL2/KDR/CASP3/TP53/MCL1/IL4/IL10RA/HIF1A/HMOX1/HSPB1/IFNG/HK2/MET/MAPK8,16
BP,GO:1901522,positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus,6/160,22/18670,2.40E-08,3.60E-07,1.69E-07,RELA/TP53/VEGFA/HIF1A/NFE2L2/RUNX2,6
BP,GO:0006977,"DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest",8/160,56/18670,2.45E-08,3.65E-07,1.71E-07,CDK2/CDKN1A/BAX/TP53/CCNB1/CHEK2/E2F1/MDM2,8
BP,GO:0051403,stress-activated MAPK cascade,15/160,286/18670,2.55E-08,3.80E-07,1.78E-07,MAPK14/AKT1/EGFR/VEGFA/MAPK1/MYC/IL1B/NCF1/GSTP1/CHUK/CD40LG/APP/IKBKB/MAPK8/MAP2K4,15
BP,GO:0009896,positive regulation of catabolic process,18/160,425/18670,2.66E-08,3.94E-07,1.85E-07,ADRB2/AKT1/BAX/KDR/ADRA2A/IL4/EGF/HIF1A/HMOX1/CAV1/GJA1/IL1B/IFNG/NFE2L2/PPARA/HK2/MDM2/APP,18
BP,GO:0098754,detoxification,11/160,137/18670,2.71E-08,4.01E-07,1.88E-07,PTGS1/PTGS2/SOD1/NOS3/MPO/ABCG2/GSTP1/NFE2L2/NQO1/GSTM1/CAT,11
BP,GO:0048872,homeostasis of number of cells,14/160,246/18670,2.75E-08,4.04E-07,1.89E-07,MAPK14/AKT1/BCL2/BAX/CASP3/VEGFA/RB1/SOD1/HIF1A/STAT1/HMOX1/NOS3/IL2RA/G6PD,14
BP,GO:0070555,response to interleukin-1,13/160,207/18670,2.75E-08,4.04E-07,1.89E-07,RELA/CCL2/CXCL8/PRKCA/NFKBIA/HIF1A/ICAM1/IL1B/SELE/IL1A/CHUK/APP/IKBKB,13
BP,GO:0043525,positive regulation of neuron apoptotic process,8/160,57/18670,2.82E-08,4.10E-07,1.92E-07,BAX/CASP9/JUN/CASP3/TP53/MCL1/NQO1/MAP2K4,8
BP,GO:0072431,signal transduction involved in mitotic G1 DNA damage checkpoint,8/160,57/18670,2.82E-08,4.10E-07,1.92E-07,CDK2/CDKN1A/BAX/TP53/CCNB1/CHEK2/E2F1/MDM2,8
BP,GO:1902400,intracellular signal transduction involved in G1 DNA damage checkpoint,8/160,57/18670,2.82E-08,4.10E-07,1.92E-07,CDK2/CDKN1A/BAX/TP53/CCNB1/CHEK2/E2F1/MDM2,8
BP,GO:0007623,circadian rhythm,13/160,208/18670,2.92E-08,4.22E-07,1.98E-07,NOS2/PPARG/JUN/TP53/SLC6A4/F7/EGFR/TOP1/SERPINE1/CLDN4/PPARA/CDK4/MAPK8,13
BP,GO:0071156,regulation of cell cycle arrest,10/160,108/18670,3.04E-08,4.37E-07,2.05E-07,CDK2/CCND1/CDKN1A/BAX/TP53/CCNB1/CHEK2/E2F1/CDK4/MDM2,10
BP,GO:0042063,gliogenesis,15/160,290/18670,3.07E-08,4.40E-07,2.06E-07,PPARG/RELA/AKT1/CCL2/CHRM1/EGFR/MAPK1/SOD1/ERBB2/IL1B/IFNG/GSTP1/E2F1/ERBB3/APP,15
BP,GO:0033135,regulation of peptidyl-serine phosphorylation,11/160,139/18670,3.15E-08,4.51E-07,2.11E-07,PTGS2/AKT1/BCL2/BAX/EGFR/VEGFA/RAF1/CAV1/IFNG/CD44/APP,11
BP,GO:0045926,negative regulation of growth,14/160,249/18670,3.20E-08,4.55E-07,2.13E-07,PPARG/ADRB2/BCL2/CDKN1A/TP53/SLC6A4/ADRB1/ESR2/HIF1A/GJA1/PPARA/PPARD/SPP1/G6PD,14
BP,GO:0031663,lipopolysaccharide-mediated signaling pathway,8/160,58/18670,3.25E-08,4.62E-07,2.16E-07,MAPK14/AKT1/CCL2/PRKCA/MAPK1/NFKBIA/IL1B/NOS3,8
BP,GO:0051146,striated muscle cell differentiation,15/160,293/18670,3.52E-08,4.97E-07,2.33E-07,RXRA/MAPK14/AKT1/BCL2/CASP3/VEGFA/RB1/CCNB1/PPARA/CXCL10/CHUK/IGF2/G6PD/PPP3CA/MAP2K4,15
BP,GO:0016049,cell growth,19/160,484/18670,3.57E-08,5.03E-07,2.36E-07,PPARG/AKT1/BCL2/CDKN1A/TP53/FN1/ESR2/EGFR/VEGFA/RB1/ERBB2/GJA1/PPARA/PPARD/SPP1/IGFBP3/APP/G6PD/MAP2K4,19
BP,GO:0033559,unsaturated fatty acid metabolic process,10/160,110/18670,3.62E-08,5.09E-07,2.38E-07,PTGS1/PTGS2/CYP1A2/CYP2B6/CYP1A1/IL1B/CYP1B1/ALOX5/GSTP1/ACOX1,10
BP,GO:1902042,negative regulation of extrinsic apoptotic signaling pathway via death domain receptors,7/160,39/18670,3.64E-08,5.09E-07,2.38E-07,CASP8/BCL2L1/RAF1/HMOX1/ICAM1/NOS3/SERPINE1,7
BP,GO:0042391,regulation of membrane potential,18/160,434/18670,3.66E-08,5.11E-07,2.39E-07,SCN5A/ADRB2/AKT1/BCL2/BAX/KDR/JUN/CHRM1/OPRM1/ADRB1/HTR3A/BCL2L1/SOD1/CAV1/GJA1/PARP1/APP/PPP3CA,18
BP,GO:0072413,signal transduction involved in mitotic cell cycle checkpoint,8/160,59/18670,3.74E-08,5.14E-07,2.41E-07,CDK2/CDKN1A/BAX/TP53/CCNB1/CHEK2/E2F1/MDM2,8
BP,GO:0097755,positive regulation of blood vessel diameter,8/160,59/18670,3.74E-08,5.14E-07,2.41E-07,ADRB2/ADRB1/EGFR/SOD1/HMOX1/GJA1/NOS3/PPARD,8
BP,GO:1902402,signal transduction involved in mitotic DNA damage checkpoint,8/160,59/18670,3.74E-08,5.14E-07,2.41E-07,CDK2/CDKN1A/BAX/TP53/CCNB1/CHEK2/E2F1/MDM2,8
BP,GO:1902403,signal transduction involved in mitotic DNA integrity checkpoint,8/160,59/18670,3.74E-08,5.14E-07,2.41E-07,CDK2/CDKN1A/BAX/TP53/CCNB1/CHEK2/E2F1/MDM2,8
BP,GO:0038127,ERBB signaling pathway,11/160,142/18670,3.94E-08,5.40E-07,2.53E-07,AKT1/PRKCA/ADRA2A/MMP9/EGFR/MAPK1/EGF/ERBB2/NCF1/ERBB3/APP,11
BP,GO:0048469,cell maturation,12/160,177/18670,4.14E-08,5.65E-07,2.65E-07,PPARG/BCL2/CDKN1A/PGR/VEGFA/RB1/HIF1A/GJA1/CCNB1/RUNX2/APP/G6PD,12
BP,GO:1903522,regulation of blood circulation,15/160,297/18670,4.20E-08,5.72E-07,2.68E-07,SCN5A/PTGS2/AKT1/CHRM3/ADRA2A/ADRB1/ADRA2C/ADRA2B/EGFR/CAV1/GJA1/ICAM1/NOS3/MDM2/ECE1,15
BP,GO:0060249,anatomical structure homeostasis,18/160,439/18670,4.35E-08,5.91E-07,2.77E-07,PTGS2/ADRB2/BCL2/BAX/TEP1/PRKCA/CA2/EGFR/VEGFA/MAPK1/RB1/SOD1/HIF1A/MYC/NOS3/HSPB1/PARP1/SPP1,18
BP,GO:0010821,regulation of mitochondrion organization,12/160,179/18670,4.69E-08,6.30E-07,2.95E-07,AKT1/BCL2/BAX/KDR/TP53/CASP8/MMP9/BCL2L1/HIF1A/E2F1/HK2/MAPK8,12
BP,GO:0043200,response to amino acid,10/160,113/18670,4.69E-08,6.30E-07,2.95E-07,RELA/CASP3/F7/MMP2/EGFR/BCL2L1/ICAM1/COL1A1/GSTP1/CHUK,10
BP,GO:0046620,regulation of organ growth,10/160,113/18670,4.69E-08,6.30E-07,2.95E-07,MAPK14/AKT1/SLC6A4/MAPK1/POR/SOD1/GJA1/CCNB1/PPARA/G6PD,10
BP,GO:0050920,regulation of chemotaxis,13/160,217/18670,4.81E-08,6.44E-07,3.02E-07,MAPK14/KDR/IL6R/CCL2/CXCL8/F7/VEGFA/F3/HSPB1/SERPINE1/GSTP1/CXCL10/MET,13
BP,GO:0090303,positive regulation of wound healing,8/160,61/18670,4.89E-08,6.52E-07,3.06E-07,ADRA2A/F7/F3/THBD/SERPINE1/NFE2L2/PPARD/HPSE,8
BP,GO:0010959,regulation of metal ion transport,17/160,394/18670,5.08E-08,6.76E-07,3.17E-07,SCN5A/PTGS2/ADRB2/AKT1/BCL2/BAX/CCL2/ADRA2A/EGF/CAV1/GJA1/ICAM1/NOS3/IFNG/CXCL11/CXCL10/G6PD,17
BP,GO:0008625,extrinsic apoptotic signaling pathway via death domain receptors,9/160,86/18670,5.21E-08,6.90E-07,3.23E-07,BCL2/BAX/CASP8/BCL2L1/RAF1/HMOX1/ICAM1/NOS3/SERPINE1,9
BP,GO:0010822,positive regulation of mitochondrion organization,10/160,116/18670,6.03E-08,7.97E-07,3.73E-07,BCL2/BAX/KDR/TP53/CASP8/MMP9/HIF1A/E2F1/HK2/MAPK8,10
BP,GO:0070663,regulation of leukocyte proliferation,13/160,222/18670,6.29E-08,8.28E-07,3.88E-07,BCL2/CDKN1A/IL6R/CASP3/IL4/ERBB2/IL1B/VCAM1/IL2RA/GSTP1/IGF2/CD40LG/IRF1,13
BP,GO:1900407,regulation of cellular response to oxidative stress,9/160,88/18670,6.38E-08,8.37E-07,3.92E-07,AKT1/MCL1/MMP3/SOD1/HIF1A/HSPB1/NFE2L2/PARP1/MET,9
BP,GO:1903708,positive regulation of hemopoiesis,12/160,185/18670,6.74E-08,8.82E-07,4.13E-07,MAPK14/JUN/CASP8/PRKCA/CA2/IL4/FOS/RB1/HIF1A/STAT1/IL2RA/IFNG,12
BP,GO:0009895,negative regulation of catabolic process,15/160,308/18670,6.78E-08,8.84E-07,4.14E-07,NOS2/MAPK14/RELA/AKT1/BCL2/TP53/MCL1/ADRA2A/EGFR/IL10RA/HMOX1/IL1B/PPARA/E2F1/MET,15
BP,GO:0030194,positive regulation of blood coagulation,6/160,26/18670,7.20E-08,9.33E-07,4.37E-07,F7/F3/THBD/SERPINE1/NFE2L2/HPSE,6
BP,GO:1900048,positive regulation of hemostasis,6/160,26/18670,7.20E-08,9.33E-07,4.37E-07,F7/F3/THBD/SERPINE1/NFE2L2/HPSE,6
BP,GO:0006940,regulation of smooth muscle contraction,8/160,65/18670,8.14E-08,1.05E-06,4.91E-07,PTGS2/ADRB2/CHRM3/ADRA2A/ADRA2C/ADRA2B/SOD1/CAV1,8
BP,GO:0032768,regulation of monooxygenase activity,8/160,65/18670,8.14E-08,1.05E-06,4.91E-07,AKT1/EGFR/POR/HIF1A/CAV1/IL1B/NOS3/IFNG,8
BP,GO:0007249,I-kappaB kinase/NF-kappaB signaling,14/160,269/18670,8.37E-08,1.07E-06,5.02E-07,ESR1/RELA/AKT1/CASP8/NFKBIA/STAT1/HMOX1/GJA1/IL1B/HSPB1/GSTP1/CHUK/IKBKB/CASP1,14
BP,GO:0043491,protein kinase B signaling,14/160,269/18670,8.37E-08,1.07E-06,5.02E-07,ESR1/AKT1/KDR/CCL2/F7/EGFR/EGF/ERBB2/F3/IL1B/IGF2/ERBB3/HPSE/MET,14
BP,GO:0030168,platelet activation,11/160,153/18670,8.49E-08,1.08E-06,5.07E-07,PRKCA/ADRA2A/ADRA2C/ADRA2B/MAPK1/RAF1/NOS3/HSPB1/THBD/COL1A1/CD40LG,11
BP,GO:0014909,smooth muscle cell migration,9/160,91/18670,8.56E-08,1.08E-06,5.08E-07,BCL2/PLAU/PLAT/SERPINE1/GSTP1/NFE2L2/PPARD/IGFBP3/MDM2,9
BP,GO:1901992,positive regulation of mitotic cell cycle phase transition,9/160,91/18670,8.56E-08,1.08E-06,5.08E-07,AKT1/CCND1/EGFR/RB1/CYP1A1/CCNB1/CDK4/MDM2/APP,9
BP,GO:0030225,macrophage differentiation,7/160,44/18670,8.74E-08,1.10E-06,5.17E-07,CASP8/PRKCA/MMP9/VEGFA/RB1/PARP1/APP,7
BP,GO:0007548,sex differentiation,14/160,270/18670,8.77E-08,1.10E-06,5.17E-07,ESR1/AR/CCND1/BCL2/BAX/CASP3/PGR/VEGFA/BCL2L1/SOD1/HSPA5/GJA1/ICAM1/NOS3,14
BP,GO:0019216,regulation of lipid metabolic process,17/160,410/18670,9.01E-08,1.13E-06,5.29E-07,PPARG/PTGS2/RXRA/AKT1/ADRA2A/RB1/POR/SOD1/CAV1/CYP1A1/IL1B/IFNG/PPARA/PPARD/CDK4/UGT1A1/ACOX1,17
BP,GO:0001894,tissue homeostasis,13/160,229/18670,9.04E-08,1.13E-06,5.29E-07,PTGS2/ADRB2/BCL2/BAX/PRKCA/CA2/EGFR/VEGFA/RB1/SOD1/NOS3/HSPB1/SPP1,13
BP,GO:0032388,positive regulation of intracellular transport,13/160,229/18670,9.04E-08,1.13E-06,5.29E-07,PTGS2/MAPK14/BCL2/TP53/CHRM1/CASP8/MAPK1/ERBB2/IL1B/IFNG/E2F1/MDM2/MAPK8,13
BP,GO:0031098,stress-activated protein kinase signaling cascade,15/160,315/18670,9.09E-08,1.13E-06,5.30E-07,MAPK14/AKT1/EGFR/VEGFA/MAPK1/MYC/IL1B/NCF1/GSTP1/CHUK/CD40LG/APP/IKBKB/MAPK8/MAP2K4,15
BP,GO:0040014,regulation of multicellular organism growth,8/160,66/18670,9.20E-08,1.14E-06,5.32E-07,ADRB2/BCL2/SLC6A3/ADRB1/SOD1/IGF2/CDK4/APP,8
BP,GO:0050820,positive regulation of coagulation,6/160,27/18670,9.20E-08,1.14E-06,5.32E-07,F7/F3/THBD/SERPINE1/NFE2L2/HPSE,6
BP,GO:0009743,response to carbohydrate,13/160,230/18670,9.52E-08,1.17E-06,5.49E-07,PTGS2/CASP3/ADRA2A/RAF1/HIF1A/GJA1/ICAM1/IL1B/GSTP1/PPARD/PPP3CA/CAT/MAP2K4,13
BP,GO:0071478,cellular response to radiation,12/160,191/18670,9.57E-08,1.18E-06,5.51E-07,PTGS2/MAPK14/CDKN1A/BAX/CASP9/TP53/BCL2L1/HSPA5/MYC/PARP1/CHEK2/MDM2,12
BP,GO:0032868,response to insulin,14/160,272/18670,9.60E-08,1.18E-06,5.51E-07,PPARG/RELA/AKT1/STAT1/ICAM1/IL1B/GSTP1/PARP1/SLC2A4/INSRR/PPARA/IGF2/CDK4/CAT,14
BP,GO:0050731,positive regulation of peptidyl-tyrosine phosphorylation,12/160,192/18670,1.01E-07,1.24E-06,5.80E-07,IL6R/TP53/ADRA2A/IL4/VEGFA/EGF/ICAM1/IFNG/NCF1/IGF2/ERBB3/CD44,12
BP,GO:0007589,body fluid secretion,9/160,93/18670,1.03E-07,1.25E-06,5.88E-07,CCND1/CHRM3/CHRM1/SLC6A3/VEGFA/HIF1A/CAV1/GJA1/HK2,9
BP,GO:0043535,regulation of blood vessel endothelial cell migration,11/160,156/18670,1.04E-07,1.25E-06,5.88E-07,PPARG/PTGS2/AKT1/KDR/PRKCA/VEGFA/HIF1A/HMOX1/NOS3/HSPB1/NFE2L2,11
BP,GO:0042108,positive regulation of cytokine biosynthetic process,8/160,67/18670,1.04E-07,1.25E-06,5.88E-07,RELA/HMOX1/IL1B/HSPB1/IFNG/IL1A/IRF1/APP,8
BP,GO:0043542,endothelial cell migration,14/160,274/18670,1.05E-07,1.27E-06,5.93E-07,PPARG/PTGS2/DPP4/AKT1/KDR/PRKCA/VEGFA/HIF1A/HMOX1/NOS3/HSPB1/CYP1B1/NFE2L2/MET,14
BP,GO:0071695,anatomical structure maturation,13/160,232/18670,1.05E-07,1.27E-06,5.93E-07,PPARG/BCL2/CDKN1A/PGR/MMP2/VEGFA/RB1/HIF1A/GJA1/CCNB1/RUNX2/APP/G6PD,13
BP,GO:0009755,hormone-mediated signaling pathway,13/160,233/18670,1.11E-07,1.33E-06,6.21E-07,ESR1/AR/PPARG/RXRA/PGR/ESR2/RB1/NR1I2/PARP1/NR1I3/PPARA/PPARD/NR3C1,13
BP,GO:0001558,regulation of cell growth,17/160,416/18670,1.11E-07,1.33E-06,6.21E-07,PPARG/AKT1/BCL2/CDKN1A/TP53/FN1/ESR2/EGFR/VEGFA/RB1/ERBB2/GJA1/PPARA/PPARD/SPP1/IGFBP3/G6PD,17
BP,GO:0051770,positive regulation of nitric-oxide synthase biosynthetic process,5/160,15/18670,1.22E-07,1.45E-06,6.79E-07,KDR/CCL2/STAT1/IFNG/MAP2K4,5
BP,GO:0006066,alcohol metabolic process,16/160,370/18670,1.25E-07,1.48E-06,6.94E-07,RXRA/PON1/CYP3A4/CYP1A2/IL4/POR/SOD1/CYP1A1/IL1B/SULT1E1/CYP1B1/IFNG/PPARD/APP/G6PD/CAT,16
BP,GO:0002685,regulation of leukocyte migration,12/160,196/18670,1.27E-07,1.50E-06,7.05E-07,MAPK14/AKT1/IL6R/CCL2/CXCL8/F7/VEGFA/HMOX1/ICAM1/SERPINE1/CXCL10/APP,12
BP,GO:0010952,positive regulation of peptidase activity,12/160,197/18670,1.34E-07,1.59E-06,7.43E-07,PPARG/MAPK14/BAX/CASP9/FN1/CASP8/CAV1/MYC/F3/CTSD/APP/CASP1,12
BP,GO:0043122,regulation of I-kappaB kinase/NF-kappaB signaling,13/160,237/18670,1.35E-07,1.59E-06,7.44E-07,ESR1/RELA/AKT1/CASP8/STAT1/HMOX1/GJA1/IL1B/HSPB1/GSTP1/CHUK/IKBKB/CASP1,13
BP,GO:1903706,regulation of hemopoiesis,18/160,475/18670,1.42E-07,1.67E-06,7.81E-07,MAPK14/JUN/CASP8/PRKCA/CA2/IL4/FOS/RB1/NFKBIA/SOD1/HIF1A/STAT1/ERBB2/MYC/IL2RA/IFNG/NFE2L2/IRF1,18
BP,GO:0010575,positive regulation of vascular endothelial growth factor production,6/160,29/18670,1.46E-07,1.70E-06,7.98E-07,PTGS2/HIF1A/IL1B/CYP1B1/IL1A/HPSE,6
BP,GO:0044773,mitotic DNA damage checkpoint,9/160,97/18670,1.49E-07,1.74E-06,8.14E-07,CDK2/CCND1/CDKN1A/BAX/TP53/CCNB1/CHEK2/E2F1/MDM2,9
BP,GO:1902882,regulation of response to oxidative stress,9/160,97/18670,1.49E-07,1.74E-06,8.14E-07,AKT1/MCL1/MMP3/SOD1/HIF1A/HSPB1/NFE2L2/PARP1/MET,9
BP,GO:0007595,lactation,7/160,48/18670,1.63E-07,1.89E-06,8.87E-07,CCND1/SLC6A3/VEGFA/HIF1A/CAV1/GJA1/HK2,7
BP,GO:0050870,positive regulation of T cell activation,12/160,202/18670,1.76E-07,2.04E-06,9.56E-07,DPP4/AKT1/IL6R/CCL2/IL4/CAV1/IL1B/VCAM1/IL2RA/IFNG/IGF2/CD40LG,12
BP,GO:0019395,fatty acid oxidation,9/160,99/18670,1.78E-07,2.06E-06,9.64E-07,PPARG/MAPK14/AKT1/POR/PPARA/PPARD/ACOX1/EHHADH/HADHB,9
BP,GO:0001844,protein insertion into mitochondrial membrane involved in apoptotic signaling pathway,6/160,30/18670,1.81E-07,2.07E-06,9.68E-07,BCL2/BAX/TP53/CASP8/E2F1/MAPK8,6
BP,GO:0042759,long-chain fatty acid biosynthetic process,6/160,30/18670,1.81E-07,2.07E-06,9.68E-07,PTGS2/LTA4H/CYP3A4/CYP1A2/CYP1A1/ALOX5,6
BP,GO:0071480,cellular response to gamma radiation,6/160,30/18670,1.81E-07,2.07E-06,9.68E-07,CDKN1A/TP53/BCL2L1/HSPA5/CHEK2/MDM2,6
BP,GO:0007093,mitotic cell cycle checkpoint,11/160,165/18670,1.83E-07,2.09E-06,9.78E-07,CDK2/CCND1/CDKN1A/BAX/TP53/BCL2L1/RB1/CCNB1/CHEK2/E2F1/MDM2,11
BP,GO:0061180,mammary gland epithelium development,8/160,72/18670,1.83E-07,2.09E-06,9.78E-07,ESR1/AR/AKT1/CCND1/BAX/PGR/MAPK1/HIF1A,8
BP,GO:0051249,regulation of lymphocyte activation,18/160,485/18670,1.93E-07,2.19E-06,1.03E-06,DPP4/AKT1/BCL2/CDKN1A/IL6R/CASP3/CCL2/IL4/SOD1/ERBB2/CAV1/IL1B/VCAM1/IL2RA/IFNG/IGF2/CD40LG/IRF1,18
BP,GO:0034764,positive regulation of transmembrane transport,12/160,204/18670,1.96E-07,2.22E-06,1.04E-06,MAPK14/ADRB2/AKT1/BAX/CCL2/CA2/HTR3A/IFNG/NFE2L2/CXCL11/CXCL10/G6PD,12
BP,GO:0072401,signal transduction involved in DNA integrity checkpoint,8/160,73/18670,2.05E-07,2.30E-06,1.08E-06,CDK2/CDKN1A/BAX/TP53/CCNB1/CHEK2/E2F1/MDM2,8
BP,GO:0072422,signal transduction involved in DNA damage checkpoint,8/160,73/18670,2.05E-07,2.30E-06,1.08E-06,CDK2/CDKN1A/BAX/TP53/CCNB1/CHEK2/E2F1/MDM2,8
BP,GO:1901568,fatty acid derivative metabolic process,11/160,167/18670,2.07E-07,2.32E-06,1.09E-06,PTGS1/PTGS2/PON1/LTA4H/CYP1A2/CYP2B6/CYP1A1/IL1B/CYP1B1/ALOX5/ACOX1,11
BP,GO:0034440,lipid oxidation,9/160,101/18670,2.12E-07,2.37E-06,1.11E-06,PPARG/MAPK14/AKT1/POR/PPARA/PPARD/ACOX1/EHHADH/HADHB,9
BP,GO:0043405,regulation of MAP kinase activity,15/160,337/18670,2.18E-07,2.43E-06,1.14E-06,MAPK14/ADRA2A/ADRA2B/EGFR/VEGFA/MAPK1/EGF/RAF1/SOD1/ERBB2/CAV1/IL1B/GSTP1/CD40LG/MAP2K4,15
BP,GO:0009409,response to cold,7/160,50/18670,2.18E-07,2.43E-06,1.14E-06,PPARG/ADRB2/CASP8/ADRB1/FOS/NFKBIA/CXCL10,7
BP,GO:1902895,positive regulation of pri-miRNA transcription by RNA polymerase II,6/160,31/18670,2.22E-07,2.47E-06,1.16E-06,RELA/JUN/TP53/FOS/HIF1A/NR3C1,6
BP,GO:0045930,negative regulation of mitotic cell cycle,15/160,338/18670,2.26E-07,2.50E-06,1.17E-06,CDK2/CCND1/BCL2/CDKN1A/BAX/TP53/CCL2/EGFR/BCL2L1/RB1/CCNB1/CHEK2/E2F1/CDK4/MDM2,15
BP,GO:0072395,signal transduction involved in cell cycle checkpoint,8/160,74/18670,2.28E-07,2.50E-06,1.17E-06,CDK2/CDKN1A/BAX/TP53/CCNB1/CHEK2/E2F1/MDM2,8
BP,GO:1903036,positive regulation of response to wounding,8/160,74/18670,2.28E-07,2.50E-06,1.17E-06,ADRA2A/F7/F3/THBD/SERPINE1/NFE2L2/PPARD/HPSE,8
BP,GO:1901991,negative regulation of mitotic cell cycle phase transition,13/160,248/18670,2.28E-07,2.50E-06,1.17E-06,CDK2/CCND1/BCL2/CDKN1A/BAX/TP53/CCL2/RB1/CCNB1/CHEK2/E2F1/CDK4/MDM2,13
BP,GO:0002064,epithelial cell development,12/160,207/18670,2.30E-07,2.51E-06,1.17E-06,ESR1/AR/CDKN1A/PGR/VEGFA/SOD1/HIF1A/GJA1/ICAM1/IL1B/MET/IKBKB,12
BP,GO:0030073,insulin secretion,12/160,207/18670,2.30E-07,2.51E-06,1.17E-06,NOS2/DPP4/PRKCA/ADRA2A/ADRA2C/RAF1/HIF1A/GJA1/IL1B/IFNG/PPARD/PPP3CA,12
BP,GO:0098869,cellular oxidant detoxification,9/160,102/18670,2.31E-07,2.51E-06,1.18E-06,PTGS1/PTGS2/SOD1/NOS3/MPO/GSTP1/NFE2L2/NQO1/CAT,9
BP,GO:0050670,regulation of lymphocyte proliferation,12/160,208/18670,2.42E-07,2.61E-06,1.22E-06,BCL2/CDKN1A/IL6R/CASP3/IL4/ERBB2/IL1B/VCAM1/IL2RA/IGF2/CD40LG/IRF1,12
BP,GO:0090276,regulation of peptide hormone secretion,12/160,208/18670,2.42E-07,2.61E-06,1.22E-06,NOS2/DPP4/PRKCA/ADRA2A/ADRA2C/EGFR/HIF1A/GJA1/IL1B/IFNG/PPARD/PPP3CA,12
BP,GO:1901215,negative regulation of neuron death,12/160,208/18670,2.42E-07,2.61E-06,1.22E-06,AKT1/BCL2/BAX/JUN/CCL2/BCL2L1/SOD1/HIF1A/HMOX1/PPARA/ERBB3/MAP2K4,12
BP,GO:0031649,heat generation,5/160,17/18670,2.47E-07,2.66E-06,1.25E-06,PTGS2/ADRB2/ADRB1/IL1B/IL1A,5
BP,GO:0010951,negative regulation of endopeptidase activity,13/160,250/18670,2.50E-07,2.67E-06,1.25E-06,PTGS2/AKT1/MMP9/VEGFA/POR/RAF1/BIRC5/SERPINE1/CD44/MDM2/APP/XIAP/SLPI,13
BP,GO:0030072,peptide hormone secretion,13/160,250/18670,2.50E-07,2.67E-06,1.25E-06,NOS2/DPP4/PRKCA/ADRA2A/ADRA2C/EGFR/RAF1/HIF1A/GJA1/IL1B/IFNG/PPARD/PPP3CA,13
BP,GO:0033157,regulation of intracellular protein transport,13/160,250/18670,2.50E-07,2.67E-06,1.25E-06,PTGS2/MAPK14/BCL2/TP53/CHRM1/CASP8/MAPK1/ERBB2/IL1B/IFNG/E2F1/MDM2/MAPK8,13
BP,GO:0032091,negative regulation of protein binding,9/160,103/18670,2.51E-07,2.67E-06,1.25E-06,ADRB2/AKT1/BAX/HSPA5/CAV1/PPARA/MET/MAPK8/SLPI,9
BP,GO:0032944,regulation of mononuclear cell proliferation,12/160,209/18670,2.55E-07,2.70E-06,1.27E-06,BCL2/CDKN1A/IL6R/CASP3/IL4/ERBB2/IL1B/VCAM1/IL2RA/IGF2/CD40LG/IRF1,12
BP,GO:0071229,cellular response to acid chemical,12/160,209/18670,2.55E-07,2.70E-06,1.27E-06,PPARG/AKT1/KDR/SLC6A4/MMP2/EGFR/VEGFA/BCL2L1/CCNB1/COL1A1/E2F1/CDK4,12
BP,GO:0045637,regulation of myeloid cell differentiation,13/160,251/18670,2.61E-07,2.76E-06,1.29E-06,MAPK14/JUN/CASP8/PRKCA/CA2/IL4/FOS/RB1/NFKBIA/HIF1A/STAT1/MYC/IFNG,13
BP,GO:0051385,response to mineralocorticoid,6/160,32/18670,2.72E-07,2.86E-06,1.34E-06,CCND1/CDKN1A/FOS/PARP1/HSD3B2/HSD3B1,6
BP,GO:0014812,muscle cell migration,9/160,104/18670,2.73E-07,2.87E-06,1.34E-06,BCL2/PLAU/PLAT/SERPINE1/GSTP1/NFE2L2/PPARD/IGFBP3/MDM2,9
BP,GO:1901990,regulation of mitotic cell cycle phase transition,17/160,444/18670,2.79E-07,2.93E-06,1.37E-06,CDK2/AKT1/CCND1/BCL2/CDKN1A/BAX/TP53/CCL2/EGFR/RB1/CYP1A1/CCNB1/CHEK2/E2F1/CDK4/MDM2/APP,17
BP,GO:0046902,regulation of mitochondrial membrane permeability,8/160,76/18670,2.81E-07,2.94E-06,1.38E-06,BCL2/BAX/TP53/CASP8/BCL2L1/E2F1/HK2/MAPK8,8
BP,GO:0001659,temperature homeostasis,11/160,173/18670,2.96E-07,3.08E-06,1.45E-06,PTGS2/ADRB2/ACHE/ADRB1/IL4/VEGFA/RB1/CAV1/GJA1/IL1B/IL1A,11
BP,GO:0051924,regulation of calcium ion transport,13/160,254/18670,3.00E-07,3.12E-06,1.46E-06,PTGS2/BCL2/BAX/CCL2/ADRA2A/EGF/CAV1/GJA1/ICAM1/NOS3/CXCL11/CXCL10/G6PD,13
BP,GO:0044774,mitotic DNA integrity checkpoint,9/160,106/18670,3.21E-07,3.32E-06,1.56E-06,CDK2/CCND1/CDKN1A/BAX/TP53/CCNB1/CHEK2/E2F1/MDM2,9
BP,GO:1901989,positive regulation of cell cycle phase transition,9/160,106/18670,3.21E-07,3.32E-06,1.56E-06,AKT1/CCND1/EGFR/RB1/CYP1A1/CCNB1/CDK4/MDM2/APP,9
BP,GO:0051186,cofactor metabolic process,17/160,449/18670,3.27E-07,3.37E-06,1.58E-06,PTGS2/PRSS1/AKT1/CYP1A2/MMP3/EGFR/SOD1/HMOX1/CYP1A1/NOS3/MPO/GSTP1/NFE2L2/GSTM1/G6PD/UGT1A1/CAT,17
BP,GO:0007187,"G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger",13/160,256/18670,3.28E-07,3.37E-06,1.58E-06,ADRB2/CCL2/CHRM3/CHRM1/OPRM1/PRKCA/ADRA2A/ADRB1/ADRA2C/ADRA2B/CXCL11/CXCL10/ADCY2,13
BP,GO:0007189,adenylate cyclase-activating G protein-coupled receptor signaling pathway,10/160,139/18670,3.33E-07,3.42E-06,1.60E-06,ADRB2/OPRM1/PRKCA/ADRA2A/ADRB1/ADRA2C/ADRA2B/CXCL11/CXCL10/ADCY2,10
BP,GO:0072347,response to anesthetic,8/160,78/18670,3.44E-07,3.52E-06,1.65E-06,RELA/SLC6A3/OPRM1/F7/CCNA2/HTR3A/HSPA5/MDM2,8
BP,GO:0030330,"DNA damage response, signal transduction by p53 class mediator",9/160,107/18670,3.48E-07,3.56E-06,1.67E-06,CDK2/CDKN1A/BAX/TP53/CCNB1/CHEK2/E2F1/CD44/MDM2,9
BP,GO:0050796,regulation of insulin secretion,11/160,176/18670,3.52E-07,3.58E-06,1.68E-06,NOS2/DPP4/PRKCA/ADRA2A/ADRA2C/HIF1A/GJA1/IL1B/IFNG/PPARD/PPP3CA,11
BP,GO:0043406,positive regulation of MAP kinase activity,13/160,258/18670,3.58E-07,3.64E-06,1.71E-06,MAPK14/ADRA2A/ADRA2B/EGFR/VEGFA/MAPK1/EGF/RAF1/SOD1/ERBB2/IL1B/CD40LG/MAP2K4,13
BP,GO:0000075,cell cycle checkpoint,12/160,216/18670,3.63E-07,3.68E-06,1.73E-06,MAPK14/CDK2/CCND1/CDKN1A/BAX/TP53/BCL2L1/RB1/CCNB1/CHEK2/E2F1/MDM2,12
BP,GO:0002763,positive regulation of myeloid leukocyte differentiation,7/160,54/18670,3.76E-07,3.80E-06,1.78E-06,JUN/CASP8/PRKCA/CA2/FOS/RB1/IFNG,7
BP,GO:0016485,protein processing,12/160,217/18670,3.82E-07,3.84E-06,1.80E-06,CASP3/CASP8/PLAU/F7/F3/PLAT/SERPINE1/PARP1/MDM2/XIAP/ECE1/CASP1,12
BP,GO:0043393,regulation of protein binding,12/160,217/18670,3.82E-07,3.84E-06,1.80E-06,ADRB2/AKT1/BCL2/BAX/MMP9/HSPA5/CAV1/PPARA/APP/MET/MAPK8/SLPI,12
BP,GO:0010574,regulation of vascular endothelial growth factor production,6/160,34/18670,3.98E-07,3.98E-06,1.86E-06,PTGS2/HIF1A/IL1B/CYP1B1/IL1A/HPSE,6
BP,GO:0043276,anoikis,6/160,34/18670,3.98E-07,3.98E-06,1.86E-06,AKT1/BCL2/MCL1/CAV1/CHEK2/E2F1,6
BP,GO:0010001,glial cell differentiation,12/160,218/18670,4.01E-07,4.00E-06,1.88E-06,PPARG/RELA/AKT1/EGFR/MAPK1/SOD1/ERBB2/IL1B/IFNG/GSTP1/ERBB3/APP,12
BP,GO:2001235,positive regulation of apoptotic signaling pathway,11/160,179/18670,4.17E-07,4.15E-06,1.94E-06,BCL2/BAX/TP53/MCL1/CASP8/MMP9/BCL2L1/SOD1/CAV1/E2F1/MAPK8,11
BP,GO:0001505,regulation of neurotransmitter levels,15/160,355/18670,4.23E-07,4.20E-06,1.97E-06,NOS2/PTGS2/AKT1/ACHE/SLC6A3/SLC6A4/MAOA/POR/CAV1/ICAM1/IL1B/NOS3/CYP1B1/IFNG/NQO1,15
BP,GO:0010466,negative regulation of peptidase activity,13/160,262/18670,4.27E-07,4.22E-06,1.98E-06,PTGS2/AKT1/MMP9/VEGFA/POR/RAF1/BIRC5/SERPINE1/CD44/MDM2/APP/XIAP/SLPI,13
BP,GO:0046883,regulation of hormone secretion,13/160,262/18670,4.27E-07,4.22E-06,1.98E-06,NOS2/DPP4/PRKCA/ADRA2A/ADRA2C/EGFR/HIF1A/GJA1/IL1B/IFNG/PPARD/SPP1/PPP3CA,13
BP,GO:0001541,ovarian follicle development,7/160,55/18670,4.28E-07,4.22E-06,1.98E-06,ESR1/BCL2/BAX/VEGFA/BCL2L1/SOD1/ICAM1,7
BP,GO:0046879,hormone secretion,14/160,308/18670,4.37E-07,4.30E-06,2.01E-06,NOS2/DPP4/PRKCA/ADRA2A/ADRA2C/EGFR/RAF1/HIF1A/GJA1/IL1B/IFNG/PPARD/SPP1/PPP3CA,14
BP,GO:0043534,blood vessel endothelial cell migration,11/160,180/18670,4.40E-07,4.31E-06,2.02E-06,PPARG/PTGS2/AKT1/KDR/PRKCA/VEGFA/HIF1A/HMOX1/NOS3/HSPB1/NFE2L2,11
BP,GO:0071346,cellular response to interferon-gamma,11/160,180/18670,4.40E-07,4.31E-06,2.02E-06,NOS2/PPARG/TP53/CCL2/STAT1/ICAM1/VCAM1/IFNG/IRF1/CD44/CASP1,11
BP,GO:0007188,adenylate cyclase-modulating G protein-coupled receptor signaling pathway,12/160,221/18670,4.64E-07,4.53E-06,2.12E-06,ADRB2/CHRM3/CHRM1/OPRM1/PRKCA/ADRA2A/ADRB1/ADRA2C/ADRA2B/CXCL11/CXCL10/ADCY2,12
BP,GO:0045861,negative regulation of proteolysis,15/160,358/18670,4.71E-07,4.58E-06,2.15E-06,PTGS2/AKT1/TP53/MMP9/VEGFA/POR/RAF1/BIRC5/PLAT/SERPINE1/CD44/MDM2/APP/XIAP/SLPI,15
BP,GO:1901030,positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway,6/160,35/18670,4.77E-07,4.63E-06,2.17E-06,BCL2/BAX/TP53/CASP8/E2F1/MAPK8,6
BP,GO:0000077,DNA damage checkpoint,10/160,145/18670,4.93E-07,4.78E-06,2.24E-06,MAPK14/CDK2/CCND1/CDKN1A/BAX/TP53/CCNB1/CHEK2/E2F1/MDM2,10
BP,GO:0034644,cellular response to UV,8/160,82/18670,5.08E-07,4.90E-06,2.30E-06,PTGS2/CDKN1A/BAX/CASP9/TP53/MYC/PARP1/MDM2,8
BP,GO:0071158,positive regulation of cell cycle arrest,8/160,82/18670,5.08E-07,4.90E-06,2.30E-06,CDK2/CDKN1A/BAX/TP53/CCNB1/CHEK2/E2F1/MDM2,8
BP,GO:0035264,multicellular organism growth,10/160,146/18670,5.25E-07,5.05E-06,2.37E-06,AR/ADRB2/BCL2/TP53/SLC6A3/ADRB1/SOD1/IGF2/CDK4/APP,10
BP,GO:0072331,signal transduction by p53 class mediator,13/160,267/18670,5.29E-07,5.07E-06,2.37E-06,MAPK14/CDK2/AKT1/BCL2/CDKN1A/BAX/TP53/CCNB1/CHEK2/E2F1/E2F2/CD44/MDM2,13
BP,GO:1901988,negative regulation of cell cycle phase transition,13/160,267/18670,5.29E-07,5.07E-06,2.37E-06,CDK2/CCND1/BCL2/CDKN1A/BAX/TP53/CCL2/RB1/CCNB1/CHEK2/E2F1/CDK4/MDM2,13
BP,GO:0042743,hydrogen peroxide metabolic process,7/160,57/18670,5.49E-07,5.25E-06,2.46E-06,CYP1A2/MMP3/EGFR/SOD1/CYP1A1/MPO/CAT,7
BP,GO:0002262,myeloid cell homeostasis,10/160,147/18670,5.59E-07,5.31E-06,2.49E-06,MAPK14/BAX/CASP3/VEGFA/RB1/SOD1/HIF1A/STAT1/HMOX1/G6PD,10
BP,GO:0043524,negative regulation of neuron apoptotic process,10/160,147/18670,5.59E-07,5.31E-06,2.49E-06,BCL2/BAX/JUN/CCL2/BCL2L1/SOD1/HIF1A/HMOX1/ERBB3/MAP2K4,10
BP,GO:0071236,cellular response to antibiotic,10/160,147/18670,5.59E-07,5.31E-06,2.49E-06,RELA/TP53/HSPA5/CYP1B1/NFE2L2/NQO1/MDM2/ADCY2/MET/UGT1A1,10
BP,GO:0010573,vascular endothelial growth factor production,6/160,36/18670,5.68E-07,5.35E-06,2.51E-06,PTGS2/HIF1A/IL1B/CYP1B1/IL1A/HPSE,6
BP,GO:1901099,negative regulation of signal transduction in absence of ligand,6/160,36/18670,5.68E-07,5.35E-06,2.51E-06,AKT1/BCL2/MCL1/BCL2L1/IL1B/IL1A,6
BP,GO:2001240,negative regulation of extrinsic apoptotic signaling pathway in absence of ligand,6/160,36/18670,5.68E-07,5.35E-06,2.51E-06,AKT1/BCL2/MCL1/BCL2L1/IL1B/IL1A,6
BP,GO:0042035,regulation of cytokine biosynthetic process,9/160,114/18670,5.98E-07,5.62E-06,2.64E-06,RELA/IL4/HMOX1/IL1B/HSPB1/IFNG/IL1A/IRF1/APP,9
BP,GO:0014910,regulation of smooth muscle cell migration,8/160,84/18670,6.13E-07,5.74E-06,2.69E-06,BCL2/PLAU/SERPINE1/GSTP1/NFE2L2/PPARD/IGFBP3/MDM2,8
BP,GO:0009914,hormone transport,14/160,317/18670,6.18E-07,5.78E-06,2.71E-06,NOS2/DPP4/PRKCA/ADRA2A/ADRA2C/EGFR/RAF1/HIF1A/GJA1/IL1B/IFNG/PPARD/SPP1/PPP3CA,14
BP,GO:1902041,regulation of extrinsic apoptotic signaling pathway via death domain receptors,7/160,58/18670,6.20E-07,5.79E-06,2.71E-06,CASP8/BCL2L1/RAF1/HMOX1/ICAM1/NOS3/SERPINE1,7
BP,GO:0051092,positive regulation of NF-kappaB transcription factor activity,10/160,149/18670,6.34E-07,5.90E-06,2.76E-06,AR/RELA/CAV1/ICAM1/IL1B/CHUK/CD40LG/APP/IKBKB/CAT,10
BP,GO:1905475,regulation of protein localization to membrane,11/160,187/18670,6.44E-07,5.97E-06,2.80E-06,AR/AKT1/BCL2/TP53/CASP8/EGFR/BCL2L1/ERBB2/IFNG/E2F1/MAPK8,11
BP,GO:0032963,collagen metabolic process,9/160,115/18670,6.45E-07,5.97E-06,2.80E-06,PPARG/MMP1/MMP2/MMP9/MMP3/HIF1A/COL1A1/PPARD/CTSD,9
BP,GO:1902105,regulation of leukocyte differentiation,13/160,272/18670,6.53E-07,6.03E-06,2.83E-06,JUN/CASP8/PRKCA/CA2/IL4/FOS/RB1/SOD1/ERBB2/MYC/IL2RA/IFNG/IRF1,13
BP,GO:1904705,regulation of vascular smooth muscle cell proliferation,8/160,85/18670,6.71E-07,6.18E-06,2.90E-06,PPARG/CDKN1A/JUN/MMP2/MMP9/HMOX1/GSTP1/MDM2,8
BP,GO:1990874,vascular smooth muscle cell proliferation,8/160,85/18670,6.71E-07,6.18E-06,2.90E-06,PPARG/CDKN1A/JUN/MMP2/MMP9/HMOX1/GSTP1/MDM2,8
BP,GO:0034405,response to fluid shear stress,6/160,37/18670,6.73E-07,6.18E-06,2.90E-06,PTGS2/AKT1/CA2/GJA1/NOS3/NFE2L2,6
BP,GO:0010594,regulation of endothelial cell migration,12/160,229/18670,6.78E-07,6.21E-06,2.91E-06,PPARG/PTGS2/AKT1/KDR/PRKCA/VEGFA/HIF1A/HMOX1/NOS3/HSPB1/NFE2L2/MET,12
BP,GO:0001836,release of cytochrome c from mitochondria,7/160,59/18670,6.99E-07,6.37E-06,2.98E-06,AKT1/BCL2/BAX/JUN/TP53/MMP9/BCL2L1,7
BP,GO:2000351,regulation of endothelial cell apoptotic process,7/160,59/18670,6.99E-07,6.37E-06,2.98E-06,KDR/CCL2/IL4/ICAM1/SERPINE1/NFE2L2/CD40LG,7
BP,GO:0070542,response to fatty acid,8/160,86/18670,7.35E-07,6.67E-06,3.13E-06,PPARG/PTGS2/AKT1/PON1/CCNB1/E2F1/CDK4/CAT,8
BP,GO:0090559,regulation of membrane permeability,8/160,86/18670,7.35E-07,6.67E-06,3.13E-06,BCL2/BAX/TP53/CASP8/BCL2L1/E2F1/HK2/MAPK8,8
BP,GO:0002761,regulation of myeloid leukocyte differentiation,9/160,117/18670,7.46E-07,6.76E-06,3.17E-06,JUN/CASP8/PRKCA/CA2/IL4/FOS/RB1/MYC/IFNG,9
BP,GO:0009615,response to virus,14/160,323/18670,7.73E-07,6.98E-06,3.27E-06,MAPK14/RELA/BCL2/ODC1/STAT1/CYP1A1/IL1B/HSPB1/IL2RA/IFNG/CXCL10/CHUK/IRF1/IKBKB,14
BP,GO:0051412,response to corticosterone,5/160,21/18670,7.91E-07,7.13E-06,3.34E-06,CCND1/CDKN1A/FOS/HSD3B2/HSD3B1,5
BP,GO:0032094,response to food,6/160,38/18670,7.94E-07,7.14E-06,3.34E-06,AKT1/OPRM1/CYP1A1/MPO/PPARA/G6PD,6
BP,GO:1901987,regulation of cell cycle phase transition,17/160,480/18670,8.26E-07,7.42E-06,3.47E-06,CDK2/AKT1/CCND1/BCL2/CDKN1A/BAX/TP53/CCL2/EGFR/RB1/CYP1A1/CCNB1/CHEK2/E2F1/CDK4/MDM2/APP,17
BP,GO:0043112,receptor metabolic process,11/160,192/18670,8.37E-07,7.49E-06,3.51E-06,PPARG/CXCL8/ACHE/VEGFA/EGF/HIF1A/CAV1/SELE/IFNG/PPARA/ECE1,11
BP,GO:0034103,regulation of tissue remodeling,8/160,88/18670,8.78E-07,7.81E-06,3.66E-06,BAX/TP53/PRKCA/CA2/EGFR/GJA1/SPP1/PPP3CA,8
BP,GO:0097194,execution phase of apoptosis,8/160,88/18670,8.78E-07,7.81E-06,3.66E-06,AKT1/BAX/CASP3/TP53/CASP8/BCL2L1/CASP7/CASP1,8
BP,GO:1904035,regulation of epithelial cell apoptotic process,8/160,88/18670,8.78E-07,7.81E-06,3.66E-06,KDR/CCL2/IL4/HMOX1/ICAM1/SERPINE1/NFE2L2/CD40LG,8
BP,GO:2001244,positive regulation of intrinsic apoptotic signaling pathway,7/160,61/18670,8.81E-07,7.82E-06,3.66E-06,BCL2/BAX/TP53/MCL1/BCL2L1/SOD1/CAV1,7
BP,GO:0042129,regulation of T cell proliferation,10/160,156/18670,9.67E-07,8.56E-06,4.01E-06,IL6R/CASP3/IL4/ERBB2/IL1B/VCAM1/IL2RA/IGF2/CD40LG/IRF1,10
BP,GO:0046824,positive regulation of nucleocytoplasmic transport,7/160,62/18670,9.86E-07,8.69E-06,4.07E-06,PTGS2/MAPK14/TP53/MAPK1/IL1B/IFNG/MDM2,7
BP,GO:0051205,protein insertion into membrane,7/160,62/18670,9.86E-07,8.69E-06,4.07E-06,BCL2/BAX/TP53/CASP8/EGFR/E2F1/MAPK8,7
BP,GO:0001655,urogenital system development,14/160,330/18670,9.97E-07,8.77E-06,4.11E-06,ESR1/AR/RXRA/BCL2/BAX/CASP9/IL6R/CA2/MMP9/VEGFA/ODC1/STAT1/MYC/CAT,14
BP,GO:0032409,regulation of transporter activity,13/160,283/18670,1.02E-06,8.95E-06,4.19E-06,PPARG/ADRB2/BCL2/CCL2/OPRM1/PON1/ADRA2A/HTR3A/MMP9/CAV1/GJA1/IFNG/APP,13
BP,GO:0031570,DNA integrity checkpoint,10/160,157/18670,1.02E-06,8.96E-06,4.20E-06,MAPK14/CDK2/CCND1/CDKN1A/BAX/TP53/CCNB1/CHEK2/E2F1/MDM2,10
BP,GO:0043467,regulation of generation of precursor metabolites and energy,10/160,157/18670,1.02E-06,8.96E-06,4.20E-06,NOS2/AKT1/TP53/IL4/HIF1A/CCNB1/IFNG/PPARA/IGF2/APP,10
BP,GO:1903035,negative regulation of response to wounding,8/160,90/18670,1.04E-06,9.10E-06,4.26E-06,CDKN1A/PLAU/GJA1/NOS3/PLAT/THBD/SERPINE1/SPP1,8
BP,GO:0021700,developmental maturation,13/160,284/18670,1.06E-06,9.20E-06,4.31E-06,PPARG/BCL2/CDKN1A/PGR/MMP2/VEGFA/RB1/HIF1A/GJA1/CCNB1/RUNX2/APP/G6PD,13
BP,GO:0016999,antibiotic metabolic process,9/160,122/18670,1.06E-06,9.20E-06,4.31E-06,CYP1A2/MMP3/EGFR/SOD1/CYP1A1/SULT1E1/MPO/UGT1A1/CAT,9
BP,GO:1905477,positive regulation of protein localization to membrane,9/160,122/18670,1.06E-06,9.20E-06,4.31E-06,AKT1/BCL2/TP53/CASP8/EGFR/ERBB2/IFNG/E2F1/MAPK8,9
BP,GO:0016042,lipid catabolic process,14/160,333/18670,1.11E-06,9.59E-06,4.50E-06,AKT1/ADRA2A/CYP3A4/CYP1A2/IL1B/SULT1E1/CYP1B1/PPARA/PPARD/SPP1/CDK4/ACOX1/EHHADH/HADHB,14
BP,GO:0060333,interferon-gamma-mediated signaling pathway,8/160,91/18670,1.14E-06,9.80E-06,4.59E-06,PPARG/TP53/STAT1/ICAM1/VCAM1/IFNG/IRF1/CD44,8
BP,GO:0042089,cytokine biosynthetic process,9/160,123/18670,1.14E-06,9.80E-06,4.59E-06,RELA/IL4/HMOX1/IL1B/HSPB1/IFNG/IL1A/IRF1/APP,9
BP,GO:0051251,positive regulation of lymphocyte activation,14/160,334/18670,1.15E-06,9.88E-06,4.63E-06,DPP4/AKT1/BCL2/CDKN1A/IL6R/CCL2/IL4/CAV1/IL1B/VCAM1/IL2RA/IFNG/IGF2/CD40LG,14
BP,GO:0042692,muscle cell differentiation,15/160,385/18670,1.17E-06,1.01E-05,4.71E-06,RXRA/MAPK14/AKT1/BCL2/CASP3/VEGFA/RB1/CCNB1/PPARA/CXCL10/CHUK/IGF2/G6PD/PPP3CA/MAP2K4,15
BP,GO:0034341,response to interferon-gamma,11/160,199/18670,1.19E-06,1.02E-05,4.77E-06,NOS2/PPARG/TP53/CCL2/STAT1/ICAM1/VCAM1/IFNG/IRF1/CD44/CASP1,11
BP,GO:0042107,cytokine metabolic process,9/160,124/18670,1.22E-06,1.04E-05,4.87E-06,RELA/IL4/HMOX1/IL1B/HSPB1/IFNG/IL1A/IRF1/APP,9
BP,GO:2000378,negative regulation of reactive oxygen species metabolic process,7/160,64/18670,1.23E-06,1.05E-05,4.90E-06,BCL2/TP53/MMP3/HIF1A/CAV1/HK2/G6PD,7
BP,GO:1902652,secondary alcohol metabolic process,10/160,161/18670,1.29E-06,1.10E-05,5.14E-06,RXRA/PON1/CYP3A4/IL4/POR/SOD1/PPARD/APP/G6PD/CAT,10
BP,GO:1901184,regulation of ERBB signaling pathway,8/160,93/18670,1.34E-06,1.14E-05,5.33E-06,AKT1/ADRA2A/MMP9/EGFR/EGF/ERBB2/NCF1/APP,8
BP,GO:0072577,endothelial cell apoptotic process,7/160,65/18670,1.37E-06,1.16E-05,5.42E-06,KDR/CCL2/IL4/ICAM1/SERPINE1/NFE2L2/CD40LG,7
BP,GO:0014706,striated muscle tissue development,15/160,390/18670,1.38E-06,1.16E-05,5.45E-06,RXRA/MAPK14/BCL2/VEGFA/FOS/MAPK1/RB1/CAV1/GJA1/CCNB1/PPARA/ERBB3/G6PD/PPP3CA/MAP2K4,15
BP,GO:0046688,response to copper ion,6/160,42/18670,1.47E-06,1.24E-05,5.79E-06,CYP1A2/SOD1/CYP1A1/ICAM1/IL1A/APP,6
BP,GO:0002687,positive regulation of leukocyte migration,9/160,128/18670,1.59E-06,1.34E-05,6.26E-06,MAPK14/IL6R/CXCL8/F7/VEGFA/ICAM1/SERPINE1/CXCL10/APP,9
BP,GO:0046697,decidualization,5/160,24/18670,1.62E-06,1.36E-05,6.36E-06,PTGS2/MAPK1/GJA1/PPARD/SPP1,5
BP,GO:0046886,positive regulation of hormone biosynthetic process,4/160,11/18670,1.64E-06,1.37E-05,6.42E-06,POR/HIF1A/IL1B/IFNG,4
BP,GO:0048662,negative regulation of smooth muscle cell proliferation,7/160,67/18670,1.68E-06,1.41E-05,6.58E-06,PPARG/CDKN1A/HMOX1/IFNG/GSTP1/PPARD/IGFBP3,7
BP,GO:0016125,sterol metabolic process,10/160,166/18670,1.70E-06,1.42E-05,6.65E-06,RXRA/PON1/IL4/POR/SOD1/CYP1B1/PPARD/APP/G6PD/CAT,10
BP,GO:0034284,response to monosaccharide,11/160,207/18670,1.75E-06,1.46E-05,6.83E-06,PTGS2/CASP3/ADRA2A/RAF1/HIF1A/GJA1/ICAM1/GSTP1/PPARD/PPP3CA/CAT,11
BP,GO:0043500,muscle adaptation,9/160,130/18670,1.81E-06,1.50E-05,7.03E-06,SCN5A/PRKCA/HMOX1/IL1B/NOS3/PARP1/PPARA/G6PD/PPP3CA,9
BP,GO:0050671,positive regulation of lymphocyte proliferation,9/160,130/18670,1.81E-06,1.50E-05,7.03E-06,BCL2/CDKN1A/IL6R/IL4/IL1B/VCAM1/IL2RA/IGF2/CD40LG,9
BP,GO:0035924,cellular response to vascular endothelial growth factor stimulus,7/160,68/18670,1.86E-06,1.54E-05,7.20E-06,MAPK14/RELA/AKT1/KDR/VEGFA/VCAM1/HSPB1,7
BP,GO:0050918,positive chemotaxis,7/160,68/18670,1.86E-06,1.54E-05,7.20E-06,KDR/CXCL8/F7/VEGFA/F3/CXCL10/MET,7
BP,GO:0032946,positive regulation of mononuclear cell proliferation,9/160,131/18670,1.93E-06,1.59E-05,7.44E-06,BCL2/CDKN1A/IL6R/IL4/IL1B/VCAM1/IL2RA/IGF2/CD40LG,9
BP,GO:0034105,positive regulation of tissue remodeling,6/160,44/18670,1.94E-06,1.60E-05,7.48E-06,BAX/PRKCA/CA2/EGFR/SPP1/PPP3CA,6
BP,GO:1901028,regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway,6/160,44/18670,1.94E-06,1.60E-05,7.48E-06,BCL2/BAX/TP53/CASP8/E2F1/MAPK8,6
BP,GO:0070372,regulation of ERK1 and ERK2 cascade,13/160,300/18670,1.95E-06,1.60E-05,7.49E-06,KDR/JUN/CCL2/FN1/OPRM1/PRKCA/EGFR/ERBB2/ICAM1/IL1B/GSTP1/CD44/APP,13
BP,GO:0019430,removal of superoxide radicals,5/160,25/18670,2.01E-06,1.64E-05,7.67E-06,SOD1/NOS3/MPO/NFE2L2/NQO1,5
BP,GO:0050927,positive regulation of positive chemotaxis,5/160,25/18670,2.01E-06,1.64E-05,7.67E-06,KDR/CXCL8/F7/VEGFA/F3,5
BP,GO:0042698,ovulation cycle,7/160,69/18670,2.06E-06,1.67E-05,7.84E-06,ESR1/CASP3/PGR/OPRM1/EGFR/HSPA5/NOS3,7
BP,GO:0051204,protein insertion into mitochondrial membrane,6/160,45/18670,2.23E-06,1.81E-05,8.48E-06,BCL2/BAX/TP53/CASP8/E2F1/MAPK8,6
BP,GO:0060537,muscle tissue development,15/160,408/18670,2.40E-06,1.95E-05,9.12E-06,RXRA/MAPK14/BCL2/VEGFA/FOS/MAPK1/RB1/CAV1/GJA1/CCNB1/PPARA/ERBB3/G6PD/PPP3CA/MAP2K4,15
BP,GO:2001020,regulation of response to DNA damage stimulus,11/160,214/18670,2.42E-06,1.96E-05,9.16E-06,BCL2/CASP9/TP53/MCL1/EGFR/BCL2L1/MYC/PARP1/CHEK2/CD44/MDM2,11
BP,GO:0051346,negative regulation of hydrolase activity,16/160,463/18670,2.43E-06,1.96E-05,9.16E-06,PTGS2/AKT1/TP53/MMP9/VEGFA/POR/RAF1/BIRC5/NOS3/SERPINE1/CD44/MDM2/APP/XIAP/IKBKB/SLPI,16
BP,GO:0010623,programmed cell death involved in cell development,4/160,12/18670,2.44E-06,1.96E-05,9.16E-06,BCL2/BAX/IL1B/IL1A,4
BP,GO:0033197,response to vitamin E,4/160,12/18670,2.44E-06,1.96E-05,9.16E-06,PPARG/CCND1/COL1A1/CAT,4
BP,GO:0045080,positive regulation of chemokine biosynthetic process,4/160,12/18670,2.44E-06,1.96E-05,9.16E-06,HMOX1/IL1B/IFNG/APP,4
BP,GO:0032800,receptor biosynthetic process,5/160,26/18670,2.47E-06,1.97E-05,9.21E-06,PPARG/ACHE/HIF1A/IFNG/PPARA,5
BP,GO:0050926,regulation of positive chemotaxis,5/160,26/18670,2.47E-06,1.97E-05,9.21E-06,KDR/CXCL8/F7/VEGFA/F3,5
BP,GO:1900739,regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway,5/160,26/18670,2.47E-06,1.97E-05,9.21E-06,BCL2/TP53/CASP8/E2F1/MAPK8,5
BP,GO:1900740,positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway,5/160,26/18670,2.47E-06,1.97E-05,9.21E-06,BCL2/TP53/CASP8/E2F1/MAPK8,5
BP,GO:0071479,cellular response to ionizing radiation,7/160,71/18670,2.50E-06,1.98E-05,9.30E-06,MAPK14/CDKN1A/TP53/BCL2L1/HSPA5/CHEK2/MDM2,7
BP,GO:0045981,positive regulation of nucleotide metabolic process,6/160,46/18670,2.54E-06,2.01E-05,9.41E-06,NOS2/IL4/HIF1A/NOS3/IFNG/APP,6
BP,GO:1900544,positive regulation of purine nucleotide metabolic process,6/160,46/18670,2.54E-06,2.01E-05,9.41E-06,NOS2/IL4/HIF1A/NOS3/IFNG/APP,6
BP,GO:1904036,negative regulation of epithelial cell apoptotic process,6/160,46/18670,2.54E-06,2.01E-05,9.41E-06,KDR/IL4/HMOX1/ICAM1/SERPINE1/NFE2L2,6
BP,GO:0007517,muscle organ development,15/160,410/18670,2.55E-06,2.01E-05,9.42E-06,RXRA/MAPK14/BCL2/ACHE/FOS/MAPK1/RB1/CAV1/GJA1/CCNB1/PPARA/CXCL10/ERBB3/G6PD/PPP3CA,15
BP,GO:0032869,cellular response to insulin stimulus,11/160,216/18670,2.65E-06,2.08E-05,9.76E-06,PPARG/RELA/AKT1/STAT1/IL1B/GSTP1/PARP1/SLC2A4/INSRR/IGF2/CDK4,11
BP,GO:0000079,regulation of cyclin-dependent protein serine/threonine kinase activity,8/160,102/18670,2.71E-06,2.12E-05,9.95E-06,AKT1/CCND1/CDKN1A/CASP3/CCNA2/EGFR/CCNB1/CDK4,8
BP,GO:0051881,regulation of mitochondrial membrane potential,7/160,72/18670,2.75E-06,2.15E-05,1.01E-05,AKT1/BCL2/BAX/KDR/BCL2L1/SOD1/PARP1,7
BP,GO:0015850,organic hydroxy compound transport,12/160,262/18670,2.78E-06,2.17E-05,1.02E-05,PPARG/RXRA/SLC6A3/SLC6A4/PON1/ADRA2A/ADRA2C/ADRA2B/EGF/NFKBIA/CAV1/SPP1,12
BP,GO:0034504,protein localization to nucleus,12/160,262/18670,2.78E-06,2.17E-05,1.02E-05,PTGS2/MAPK14/AKT1/CDKN1A/TP53/MAPK1/NFKBIA/COL1A1/IFNG/PARP1/MDM2/PPP3CA,12
BP,GO:0009408,response to heat,10/160,176/18670,2.89E-06,2.23E-05,1.05E-05,PTGS2/AKT1/CDKN1A/MAPK1/SOD1/HSPA5/HMOX1/NOS3/IL1A/CXCL10,10
BP,GO:0051897,positive regulation of protein kinase B signaling,10/160,176/18670,2.89E-06,2.23E-05,1.05E-05,ESR1/F7/EGFR/EGF/ERBB2/F3/IGF2/ERBB3/HPSE/MET,10
BP,GO:0006953,acute-phase response,6/160,47/18670,2.90E-06,2.23E-05,1.05E-05,PTGS2/IL6R/FN1/IL1B/IL1A/UGT1A1,6
BP,GO:0070849,response to epidermal growth factor,6/160,47/18670,2.90E-06,2.23E-05,1.05E-05,AKT1/EGFR/MAPK1/ERBB2/COL1A1/GSTP1,6
BP,GO:0090151,establishment of protein localization to mitochondrial membrane,6/160,47/18670,2.90E-06,2.23E-05,1.05E-05,BCL2/BAX/TP53/CASP8/E2F1/MAPK8,6
BP,GO:2001239,regulation of extrinsic apoptotic signaling pathway in absence of ligand,6/160,47/18670,2.90E-06,2.23E-05,1.05E-05,AKT1/BCL2/MCL1/BCL2L1/IL1B/IL1A,6
BP,GO:0035902,response to immobilization stress,5/160,27/18670,3.01E-06,2.31E-05,1.08E-05,PPARG/CYP1A2/FOS/CYP1A1/MDM2,5
BP,GO:0071450,cellular response to oxygen radical,5/160,27/18670,3.01E-06,2.31E-05,1.08E-05,SOD1/NOS3/MPO/NFE2L2/NQO1,5
BP,GO:0071451,cellular response to superoxide,5/160,27/18670,3.01E-06,2.31E-05,1.08E-05,SOD1/NOS3/MPO/NFE2L2/NQO1,5
BP,GO:0001959,regulation of cytokine-mediated signaling pathway,10/160,177/18670,3.04E-06,2.32E-05,1.09E-05,PPARG/CASP8/HIF1A/STAT1/CAV1/IFNG/GSTP1/CHUK/IKBKB/CASP1,10
BP,GO:0070665,positive regulation of leukocyte proliferation,9/160,139/18670,3.15E-06,2.41E-05,1.13E-05,BCL2/CDKN1A/IL6R/IL4/IL1B/VCAM1/IL2RA/IGF2/CD40LG,9
BP,GO:0051099,positive regulation of binding,10/160,179/18670,3.36E-06,2.56E-05,1.20E-05,PPARG/PON1/MMP9/EGF/RB1/CAV1/IFNG/PARP1/APP/MET,10
BP,GO:0071347,cellular response to interleukin-1,10/160,179/18670,3.36E-06,2.56E-05,1.20E-05,RELA/CCL2/CXCL8/NFKBIA/HIF1A/ICAM1/IL1B/IL1A/CHUK/IKBKB,10
BP,GO:0055017,cardiac muscle tissue growth,8/160,105/18670,3.37E-06,2.56E-05,1.20E-05,RXRA/MAPK14/MAPK1/GJA1/CCNB1/PPARA/G6PD/MAP2K4,8
BP,GO:0042178,xenobiotic catabolic process,4/160,13/18670,3.50E-06,2.65E-05,1.24E-05,CYP1A1/GSTP1/GSTM1/UGT1A1,4
BP,GO:0090399,replicative senescence,4/160,13/18670,3.50E-06,2.65E-05,1.24E-05,CDKN1A/TP53/SERPINE1/CHEK2,4
BP,GO:0045444,fat cell differentiation,11/160,223/18670,3.60E-06,2.72E-05,1.28E-05,PPARG/PTGS2/MAPK14/ADRB2/AKT1/CCND1/ADRB1/SULT1E1/SLC2A4/PPARD/E2F1,11
BP,GO:1904029,regulation of cyclin-dependent protein kinase activity,8/160,106/18670,3.61E-06,2.73E-05,1.28E-05,AKT1/CCND1/CDKN1A/CASP3/CCNA2/EGFR/CCNB1/CDK4,8
BP,GO:0008209,androgen metabolic process,5/160,28/18670,3.64E-06,2.73E-05,1.28E-05,ESR1/CYP3A4/SPP1/HSD3B2/HSD3B1,5
BP,GO:1990776,response to angiotensin,5/160,28/18670,3.64E-06,2.73E-05,1.28E-05,PTGS2/RELA/CA2/CAV1/NFE2L2,5
BP,GO:0030857,negative regulation of epithelial cell differentiation,6/160,49/18670,3.72E-06,2.79E-05,1.31E-05,CCND1/MMP9/VEGFA/STAT1/CAV1/IFNG,6
BP,GO:0030595,leukocyte chemotaxis,11/160,224/18670,3.76E-06,2.81E-05,1.32E-05,MAPK14/IL6R/CCL2/CXCL8/F7/VEGFA/IL1B/SERPINE1/CXCL11/CXCL2/CXCL10,11
BP,GO:0045927,positive regulation of growth,12/160,270/18670,3.79E-06,2.83E-05,1.33E-05,MAPK14/AKT1/BCL2/FN1/SLC6A3/EGFR/VEGFA/MAPK1/ERBB2/CCNB1/PPARD/IGF2,12
BP,GO:0032386,regulation of intracellular transport,14/160,370/18670,3.80E-06,2.83E-05,1.33E-05,PTGS2/MAPK14/BCL2/TP53/CHRM1/CASP8/MAPK1/ERBB2/HMOX1/IL1B/IFNG/E2F1/MDM2/MAPK8,14
BP,GO:0051341,regulation of oxidoreductase activity,8/160,107/18670,3.88E-06,2.89E-05,1.35E-05,AKT1/EGFR/POR/HIF1A/CAV1/IL1B/NOS3/IFNG,8
BP,GO:0061045,negative regulation of wound healing,7/160,76/18670,3.96E-06,2.94E-05,1.38E-05,CDKN1A/PLAU/GJA1/NOS3/PLAT/THBD/SERPINE1,7
BP,GO:0006606,protein import into nucleus,9/160,143/18670,3.98E-06,2.95E-05,1.38E-05,PTGS2/MAPK14/AKT1/CDKN1A/TP53/MAPK1/NFKBIA/IFNG/PPP3CA,9
BP,GO:0001701,in utero embryonic development,14/160,373/18670,4.17E-06,3.08E-05,1.45E-05,AR/RXRA/AKT1/TP53/CASP8/EGFR/VEGFA/BCL2L1/MAPK1/HIF1A/GJA1/NOS3/CCNB1/IGF2,14
BP,GO:0034765,regulation of ion transmembrane transport,16/160,483/18670,4.18E-06,3.08E-05,1.45E-05,SCN5A/ADRB2/AKT1/BAX/CCL2/OPRM1/ADRA2A/HTR3A/MMP9/CAV1/GJA1/IFNG/CXCL11/CXCL10/APP/G6PD,16
BP,GO:0002931,response to ischemia,6/160,50/18670,4.20E-06,3.09E-05,1.45E-05,BCL2/CASP9/TP53/CAV1/GJA1/HK2,6
BP,GO:1902107,positive regulation of leukocyte differentiation,9/160,144/18670,4.22E-06,3.10E-05,1.45E-05,JUN/CASP8/PRKCA/CA2/IL4/FOS/RB1/IL2RA/IFNG,9
BP,GO:0019933,cAMP-mediated signaling,10/160,184/18670,4.30E-06,3.15E-05,1.48E-05,ADRB2/OPRM1/PRKCA/ADRA2A/ADRB1/ADRA2C/ADRA2B/CXCL11/CXCL10/ADCY2,10
BP,GO:0048639,positive regulation of developmental growth,10/160,184/18670,4.30E-06,3.15E-05,1.48E-05,MAPK14/AKT1/BCL2/FN1/SLC6A3/VEGFA/MAPK1/CCNB1/PPARD/IGF2,10
BP,GO:0000303,response to superoxide,5/160,29/18670,4.37E-06,3.20E-05,1.50E-05,SOD1/NOS3/MPO/NFE2L2/NQO1,5
BP,GO:0019369,arachidonic acid metabolic process,6/160,51/18670,4.72E-06,3.43E-05,1.61E-05,PTGS1/PTGS2/CYP1A2/CYP2B6/CYP1A1/CYP1B1,6
BP,GO:0050999,regulation of nitric-oxide synthase activity,6/160,51/18670,4.72E-06,3.43E-05,1.61E-05,AKT1/EGFR/HIF1A/CAV1/IL1B/NOS3,6
BP,GO:0097366,response to bronchodilator,6/160,51/18670,4.72E-06,3.43E-05,1.61E-05,CDK2/CCNA2/MMP3/SOD1/ICAM1/PPP3CA,6
BP,GO:0055123,digestive system development,9/160,146/18670,4.72E-06,3.43E-05,1.61E-05,BCL2/CDKN1A/CXCL8/EGFR/RB1/HIF1A/CYP1A1/CCNB1/IGF2,9
BP,GO:0030308,negative regulation of cell growth,10/160,186/18670,4.73E-06,3.43E-05,1.61E-05,PPARG/BCL2/CDKN1A/TP53/ESR2/GJA1/PPARA/PPARD/SPP1/G6PD,10
BP,GO:0006939,smooth muscle contraction,8/160,110/18670,4.77E-06,3.45E-05,1.62E-05,PTGS2/ADRB2/CHRM3/ADRA2A/ADRA2C/ADRA2B/SOD1/CAV1,8
BP,GO:0006816,calcium ion transport,15/160,434/18670,5.09E-06,3.68E-05,1.72E-05,PTGS2/BCL2/BAX/CCL2/OPRM1/ADRA2A/EGF/CAV1/GJA1/ICAM1/NOS3/CXCL11/CXCL10/G6PD/PPP3CA,15
BP,GO:0045913,positive regulation of carbohydrate metabolic process,7/160,79/18670,5.14E-06,3.71E-05,1.74E-05,AKT1/EGF/HIF1A/IFNG/PPARA/IGF2/APP,7
BP,GO:0002696,positive regulation of leukocyte activation,14/160,380/18670,5.16E-06,3.72E-05,1.74E-05,DPP4/AKT1/BCL2/CDKN1A/IL6R/CCL2/IL4/CAV1/IL1B/VCAM1/IL2RA/IFNG/IGF2/CD40LG,14
BP,GO:0000305,response to oxygen radical,5/160,30/18670,5.20E-06,3.73E-05,1.75E-05,SOD1/NOS3/MPO/NFE2L2/NQO1,5
BP,GO:0048147,negative regulation of fibroblast proliferation,5/160,30/18670,5.20E-06,3.73E-05,1.75E-05,PPARG/BAX/TP53/MYC/GSTP1,5
BP,GO:0014065,phosphatidylinositol 3-kinase signaling,9/160,148/18670,5.28E-06,3.78E-05,1.77E-05,AKT1/KDR/EGFR/MAPK1/ERBB2/NCF1/PPARD/ERBB3/CAT,9
BP,GO:0042176,regulation of protein catabolic process,14/160,381/18670,5.32E-06,3.80E-05,1.78E-05,NOS2/RELA/AKT1/ADRA2A/EGFR/EGF/ODC1/CAV1/GJA1/IL1B/IFNG/NFE2L2/CHEK2/MDM2,14
BP,GO:0001938,positive regulation of endothelial cell proliferation,8/160,112/18670,5.46E-06,3.89E-05,1.82E-05,AKT1/KDR/JUN/PRKCA/VEGFA/HIF1A/HMOX1/F3,8
BP,GO:0060419,heart growth,8/160,112/18670,5.46E-06,3.89E-05,1.82E-05,RXRA/MAPK14/MAPK1/GJA1/CCNB1/PPARA/G6PD/MAP2K4,8
BP,GO:0060759,regulation of response to cytokine stimulus,10/160,190/18670,5.71E-06,4.06E-05,1.90E-05,PPARG/CASP8/HIF1A/STAT1/CAV1/IFNG/GSTP1/CHUK/IKBKB/CASP1,10
BP,GO:0048640,negative regulation of developmental growth,8/160,113/18670,5.83E-06,4.13E-05,1.94E-05,ADRB2/CDKN1A/SLC6A4/ADRB1/GJA1/PPARA/SPP1/G6PD,8
BP,GO:0006914,autophagy,16/160,496/18670,5.84E-06,4.13E-05,1.94E-05,ADRB2/AKT1/BCL2/KDR/CASP3/TP53/MCL1/IL4/IL10RA/HIF1A/HMOX1/HSPB1/IFNG/HK2/MET/MAPK8,16
BP,GO:0061919,process utilizing autophagic mechanism,16/160,496/18670,5.84E-06,4.13E-05,1.94E-05,ADRB2/AKT1/BCL2/KDR/CASP3/TP53/MCL1/IL4/IL10RA/HIF1A/HMOX1/HSPB1/IFNG/HK2/MET/MAPK8,16
BP,GO:0008203,cholesterol metabolic process,9/160,150/18670,5.89E-06,4.16E-05,1.95E-05,RXRA/PON1/IL4/POR/SOD1/PPARD/APP/G6PD/CAT,9
BP,GO:0042594,response to starvation,10/160,191/18670,5.98E-06,4.22E-05,1.98E-05,PPARG/BCL2/CDKN1A/JUN/TP53/MAPK1/HSPA5/NFE2L2/UGT1A1/MAPK8,10
BP,GO:0022617,extracellular matrix disassembly,7/160,81/18670,6.08E-06,4.28E-05,2.00E-05,DPP4/PRSS1/MMP1/MMP2/MMP9/MMP3/CD44,7
BP,GO:0010165,response to X-ray,5/160,31/18670,6.16E-06,4.30E-05,2.01E-05,CCND1/CDKN1A/CASP3/TP53/THBD,5
BP,GO:0032770,positive regulation of monooxygenase activity,5/160,31/18670,6.16E-06,4.30E-05,2.01E-05,AKT1/POR/HIF1A/IL1B/IFNG,5
BP,GO:0043457,regulation of cellular respiration,5/160,31/18670,6.16E-06,4.30E-05,2.01E-05,NOS2/IL4/HIF1A/CCNB1/IFNG,5
BP,GO:0045742,positive regulation of epidermal growth factor receptor signaling pathway,5/160,31/18670,6.16E-06,4.30E-05,2.01E-05,AKT1/ADRA2A/MMP9/EGF/NCF1,5
BP,GO:0071880,adenylate cyclase-activating adrenergic receptor signaling pathway,5/160,31/18670,6.16E-06,4.30E-05,2.01E-05,ADRB2/ADRA2A/ADRB1/ADRA2C/ADRA2B,5
BP,GO:0002688,regulation of leukocyte chemotaxis,8/160,114/18670,6.23E-06,4.33E-05,2.03E-05,MAPK14/IL6R/CCL2/CXCL8/F7/VEGFA/SERPINE1/CXCL10,8
BP,GO:0032872,regulation of stress-activated MAPK cascade,11/160,237/18670,6.45E-06,4.48E-05,2.10E-05,AKT1/EGFR/VEGFA/MAPK1/MYC/IL1B/NCF1/GSTP1/CD40LG/APP/MAP2K4,11
BP,GO:0051604,protein maturation,12/160,285/18670,6.58E-06,4.55E-05,2.13E-05,CASP3/CASP8/PLAU/F7/F3/PLAT/SERPINE1/PARP1/MDM2/XIAP/ECE1/CASP1,12
BP,GO:0032352,positive regulation of hormone metabolic process,4/160,15/18670,6.59E-06,4.55E-05,2.13E-05,POR/HIF1A/IL1B/IFNG,4
BP,GO:0045073,regulation of chemokine biosynthetic process,4/160,15/18670,6.59E-06,4.55E-05,2.13E-05,HMOX1/IL1B/IFNG/APP,4
BP,GO:2001028,positive regulation of endothelial cell chemotaxis,4/160,15/18670,6.59E-06,4.55E-05,2.13E-05,KDR/VEGFA/HSPB1/MET,4
BP,GO:0032642,regulation of chemokine production,7/160,82/18670,6.60E-06,4.55E-05,2.13E-05,IL6R/HIF1A/HMOX1/IL1B/IFNG/GSTP1/APP,7
BP,GO:0097345,mitochondrial outer membrane permeabilization,6/160,54/18670,6.63E-06,4.56E-05,2.14E-05,BCL2/BAX/TP53/CASP8/E2F1/MAPK8,6
BP,GO:1900542,regulation of purine nucleotide metabolic process,8/160,115/18670,6.64E-06,4.56E-05,2.14E-05,NOS2/IL4/HIF1A/NOS3/IFNG/PARP1/PPARA/APP,8
BP,GO:0030258,lipid modification,11/160,238/18670,6.71E-06,4.60E-05,2.16E-05,PPARG/MAPK14/AKT1/CYP3A4/POR/CYP1A1/PPARA/PPARD/ACOX1/EHHADH/HADHB,11
BP,GO:0070302,regulation of stress-activated protein kinase signaling cascade,11/160,239/18670,6.99E-06,4.78E-05,2.24E-05,AKT1/EGFR/VEGFA/MAPK1/MYC/IL1B/NCF1/GSTP1/CD40LG/APP/MAP2K4,11
BP,GO:0007569,cell aging,8/160,116/18670,7.08E-06,4.84E-05,2.27E-05,MAPK14/BCL2/CDKN1A/TP53/SOD1/ICAM1/SERPINE1/CHEK2,8
BP,GO:0038128,ERBB2 signaling pathway,5/160,32/18670,7.25E-06,4.95E-05,2.32E-05,PRKCA/EGFR/EGF/ERBB2/ERBB3,5
BP,GO:0042220,response to cocaine,6/160,55/18670,7.39E-06,5.03E-05,2.36E-05,SLC6A3/OPRM1/CCNA2/HTR3A/HSPA5/MDM2,6
BP,GO:0006140,regulation of nucleotide metabolic process,8/160,117/18670,7.55E-06,5.13E-05,2.40E-05,NOS2/IL4/HIF1A/NOS3/IFNG/PARP1/PPARA/APP,8
BP,GO:0010507,negative regulation of autophagy,7/160,84/18670,7.75E-06,5.26E-05,2.46E-05,AKT1/BCL2/TP53/MCL1/IL10RA/HMOX1/MET,7
BP,GO:0050867,positive regulation of cell activation,14/160,394/18670,7.79E-06,5.28E-05,2.47E-05,DPP4/AKT1/BCL2/CDKN1A/IL6R/CCL2/IL4/CAV1/IL1B/VCAM1/IL2RA/IFNG/IGF2/CD40LG,14
BP,GO:0030856,regulation of epithelial cell differentiation,9/160,156/18670,8.11E-06,5.47E-05,2.56E-05,CCND1/MMP9/VEGFA/STAT1/CAV1/IL1B/SERPINE1/IFNG/IKBKB,9
BP,GO:1905952,regulation of lipid localization,9/160,156/18670,8.11E-06,5.47E-05,2.56E-05,PPARG/AKT1/PON1/EGF/NFKBIA/IL1B/PPARA/PPARD/SPP1,9
BP,GO:1904062,regulation of cation transmembrane transport,13/160,342/18670,8.13E-06,5.48E-05,2.57E-05,SCN5A/ADRB2/BAX/CCL2/OPRM1/ADRA2A/MMP9/CAV1/IFNG/CXCL11/CXCL10/APP/G6PD,13
BP,GO:0036003,positive regulation of transcription from RNA polymerase II promoter in response to stress,5/160,33/18670,8.49E-06,5.69E-05,2.67E-05,TP53/VEGFA/HIF1A/HSPA5/NFE2L2,5
BP,GO:1901186,positive regulation of ERBB signaling pathway,5/160,33/18670,8.49E-06,5.69E-05,2.67E-05,AKT1/ADRA2A/MMP9/EGF/NCF1,5
BP,GO:2000352,negative regulation of endothelial cell apoptotic process,5/160,33/18670,8.49E-06,5.69E-05,2.67E-05,KDR/IL4/ICAM1/SERPINE1/NFE2L2,5
BP,GO:0051896,regulation of protein kinase B signaling,11/160,244/18670,8.50E-06,5.69E-05,2.67E-05,ESR1/AKT1/F7/EGFR/EGF/ERBB2/F3/IGF2/ERBB3/HPSE/MET,11
BP,GO:0002070,epithelial cell maturation,4/160,16/18670,8.73E-06,5.78E-05,2.71E-05,CDKN1A/PGR/HIF1A/GJA1,4
BP,GO:0042033,chemokine biosynthetic process,4/160,16/18670,8.73E-06,5.78E-05,2.71E-05,HMOX1/IL1B/IFNG/APP,4
BP,GO:0042447,hormone catabolic process,4/160,16/18670,8.73E-06,5.78E-05,2.71E-05,ACHE/SULT1E1/SPP1/ECE1,4
BP,GO:0045986,negative regulation of smooth muscle contraction,4/160,16/18670,8.73E-06,5.78E-05,2.71E-05,PTGS2/ADRB2/ADRA2C/SOD1,4
BP,GO:0050755,chemokine metabolic process,4/160,16/18670,8.73E-06,5.78E-05,2.71E-05,HMOX1/IL1B/IFNG/APP,4
BP,GO:0060965,negative regulation of gene silencing by miRNA,4/160,16/18670,8.73E-06,5.78E-05,2.71E-05,ESR1/PPARG/TP53/PPP3CA,4
BP,GO:0042058,regulation of epidermal growth factor receptor signaling pathway,7/160,86/18670,9.07E-06,5.99E-05,2.81E-05,AKT1/ADRA2A/MMP9/EGFR/EGF/NCF1/APP,7
BP,GO:0042446,hormone biosynthetic process,7/160,86/18670,9.07E-06,5.99E-05,2.81E-05,CYP3A4/POR/HIF1A/IL1B/IFNG/HSD3B2/HSD3B1,7
BP,GO:0022612,gland morphogenesis,8/160,120/18670,9.10E-06,6.00E-05,2.81E-05,ESR1/AR/RXRA/BCL2/BAX/PGR/EGFR/CAV1,8
BP,GO:0007259,receptor signaling pathway via JAK-STAT,9/160,159/18670,9.46E-06,6.23E-05,2.92E-05,IL6R/CCL2/IL4/IL10RA/EGF/STAT1/CAV1/CYP1B1/IFNG,9
BP,GO:1903578,regulation of ATP metabolic process,8/160,121/18670,9.68E-06,6.36E-05,2.98E-05,TP53/IL4/HIF1A/CCNB1/IFNG/PARP1/PPARA/APP,8
BP,GO:0002690,positive regulation of leukocyte chemotaxis,7/160,87/18670,9.79E-06,6.42E-05,3.01E-05,MAPK14/IL6R/CXCL8/F7/VEGFA/SERPINE1/CXCL10,7
BP,GO:0071875,adrenergic receptor signaling pathway,5/160,34/18670,9.88E-06,6.47E-05,3.03E-05,ADRB2/ADRA2A/ADRB1/ADRA2C/ADRA2B,5
BP,GO:0032722,positive regulation of chemokine production,6/160,58/18670,1.01E-05,6.60E-05,3.09E-05,IL6R/HIF1A/HMOX1/IL1B/IFNG/APP,6
BP,GO:0071385,cellular response to glucocorticoid stimulus,6/160,58/18670,1.01E-05,6.60E-05,3.09E-05,CASP9/EGFR/ICAM1/GSTP1/NR3C1/UGT1A1,6
BP,GO:0034101,erythrocyte homeostasis,8/160,122/18670,1.03E-05,6.70E-05,3.14E-05,MAPK14/CASP3/VEGFA/RB1/HIF1A/STAT1/HMOX1/G6PD,8
BP,GO:0043388,positive regulation of DNA binding,6/160,59/18670,1.12E-05,7.27E-05,3.41E-05,PPARG/MMP9/EGF/RB1/IFNG/PARP1,6
BP,GO:0032602,chemokine production,7/160,89/18670,1.14E-05,7.40E-05,3.47E-05,IL6R/HIF1A/HMOX1/IL1B/IFNG/GSTP1/APP,7
BP,GO:0032735,positive regulation of interleukin-12 production,5/160,35/18670,1.15E-05,7.42E-05,3.48E-05,MAPK14/RELA/IFNG/CD40LG/IRF1,5
BP,GO:1904031,positive regulation of cyclin-dependent protein kinase activity,5/160,35/18670,1.15E-05,7.42E-05,3.48E-05,AKT1/CCND1/CDKN1A/EGFR/CCNB1,5
BP,GO:0051170,import into nucleus,9/160,163/18670,1.16E-05,7.47E-05,3.50E-05,PTGS2/MAPK14/AKT1/CDKN1A/TP53/MAPK1/NFKBIA/IFNG/PPP3CA,9
BP,GO:1902110,positive regulation of mitochondrial membrane permeability involved in apoptotic process,6/160,60/18670,1.23E-05,7.95E-05,3.73E-05,BCL2/BAX/TP53/CASP8/E2F1/MAPK8,6
BP,GO:0042326,negative regulation of phosphorylation,15/160,468/18670,1.25E-05,8.07E-05,3.78E-05,AKT1/CDKN1A/BAX/JUN/CASP3/RB1/CAV1/MYC/IL1B/HSPB1/CCNB1/IFNG/GSTP1/PPARA/IGFBP3,15
BP,GO:0051899,membrane depolarization,7/160,91/18670,1.32E-05,8.48E-05,3.97E-05,SCN5A/BCL2/KDR/JUN/CAV1/GJA1/PARP1,7
BP,GO:0071384,cellular response to corticosteroid stimulus,6/160,61/18670,1.36E-05,8.70E-05,4.08E-05,CASP9/EGFR/ICAM1/GSTP1/NR3C1/UGT1A1,6
BP,GO:1905953,negative regulation of lipid localization,6/160,61/18670,1.36E-05,8.70E-05,4.08E-05,PPARG/AKT1/EGF/NFKBIA/PPARA/PPARD,6
BP,GO:0097529,myeloid leukocyte migration,10/160,210/18670,1.37E-05,8.80E-05,4.13E-05,MAPK14/IL6R/CCL2/CXCL8/VEGFA/IL1B/SERPINE1/CXCL11/CXCL2/CXCL10,10
BP,GO:0043620,regulation of DNA-templated transcription in response to stress,8/160,127/18670,1.38E-05,8.83E-05,4.14E-05,RELA/JUN/TP53/VEGFA/HIF1A/HSPA5/HMOX1/NFE2L2,8
BP,GO:0033209,tumor necrosis factor-mediated signaling pathway,9/160,167/18670,1.40E-05,8.95E-05,4.19E-05,RELA/CASP8/NFKBIA/STAT1/GSTP1/CHUK/CD40LG/IKBKB/CASP1,9
BP,GO:0035051,cardiocyte differentiation,9/160,167/18670,1.40E-05,8.95E-05,4.19E-05,RXRA/EGFR/VEGFA/MAPK1/VCAM1/CCNB1/PPARA/G6PD/MAP2K4,9
BP,GO:0010948,negative regulation of cell cycle process,13/160,361/18670,1.45E-05,9.18E-05,4.30E-05,CDK2/CCND1/BCL2/CDKN1A/BAX/TP53/CCL2/RB1/CCNB1/CHEK2/E2F1/CDK4/MDM2,13
BP,GO:0045780,positive regulation of bone resorption,4/160,18/18670,1.45E-05,9.18E-05,4.30E-05,PRKCA/CA2/EGFR/SPP1,4
BP,GO:0046852,positive regulation of bone remodeling,4/160,18/18670,1.45E-05,9.18E-05,4.30E-05,PRKCA/CA2/EGFR/SPP1,4
BP,GO:0002260,lymphocyte homeostasis,6/160,62/18670,1.49E-05,9.42E-05,4.42E-05,AKT1/BCL2/BAX/CASP3/HIF1A/IL2RA,6
BP,GO:1902686,mitochondrial outer membrane permeabilization involved in programmed cell death,6/160,62/18670,1.49E-05,9.42E-05,4.42E-05,BCL2/BAX/TP53/CASP8/E2F1/MAPK8,6
BP,GO:0019935,cyclic-nucleotide-mediated signaling,10/160,212/18670,1.49E-05,9.42E-05,4.42E-05,ADRB2/OPRM1/PRKCA/ADRA2A/ADRB1/ADRA2C/ADRA2B/CXCL11/CXCL10/ADCY2,10
BP,GO:0014912,negative regulation of smooth muscle cell migration,5/160,37/18670,1.52E-05,9.54E-05,4.47E-05,SERPINE1/GSTP1/NFE2L2/PPARD/IGFBP3,5
BP,GO:0043029,T cell homeostasis,5/160,37/18670,1.52E-05,9.54E-05,4.47E-05,AKT1/BCL2/BAX/CASP3/IL2RA,5
BP,GO:0038095,Fc-epsilon receptor signaling pathway,9/160,169/18670,1.54E-05,9.69E-05,4.54E-05,RELA/JUN/FOS/MAPK1/CHUK/IKBKB/MAPK8/PPP3CA/MAP2K4,9
BP,GO:0097696,receptor signaling pathway via STAT,9/160,169/18670,1.54E-05,9.69E-05,4.54E-05,IL6R/CCL2/IL4/IL10RA/EGF/STAT1/CAV1/CYP1B1/IFNG,9
BP,GO:0071482,cellular response to light stimulus,8/160,129/18670,1.55E-05,9.69E-05,4.54E-05,PTGS2/CDKN1A/BAX/CASP9/TP53/MYC/PARP1/MDM2,8
BP,GO:0006879,cellular iron ion homeostasis,6/160,63/18670,1.64E-05,0.000102377,4.80E-05,SOD1/HIF1A/HMOX1/MYC/IFNG/ABCG2,6
BP,GO:0070838,divalent metal ion transport,15/160,479/18670,1.64E-05,0.000102638,4.81E-05,PTGS2/BCL2/BAX/CCL2/OPRM1/ADRA2A/EGF/CAV1/GJA1/ICAM1/NOS3/CXCL11/CXCL10/G6PD/PPP3CA,15
BP,GO:0006937,regulation of muscle contraction,9/160,171/18670,1.70E-05,0.000105573,4.95E-05,SCN5A/PTGS2/ADRB2/CHRM3/ADRA2A/ADRA2C/ADRA2B/SOD1/CAV1,9
BP,GO:0016241,regulation of macroautophagy,9/160,171/18670,1.70E-05,0.000105573,4.95E-05,ADRB2/AKT1/KDR/CASP3/TP53/IL4/HIF1A/HMOX1/MAPK8,9
BP,GO:0016572,histone phosphorylation,5/160,38/18670,1.73E-05,0.000107793,5.05E-05,CDK2/PRKCA/CCNA2/IL1B/CCNB1,5
BP,GO:0042102,positive regulation of T cell proliferation,7/160,95/18670,1.75E-05,0.000108505,5.08E-05,IL6R/IL4/IL1B/VCAM1/IL2RA/IGF2/CD40LG,7
BP,GO:0035794,positive regulation of mitochondrial membrane permeability,6/160,64/18670,1.79E-05,0.000110808,5.19E-05,BCL2/BAX/TP53/CASP8/E2F1/MAPK8,6
BP,GO:0045600,positive regulation of fat cell differentiation,6/160,64/18670,1.79E-05,0.000110808,5.19E-05,PPARG/PTGS2/MAPK14/AKT1/SULT1E1/PPARD,6
BP,GO:0051235,maintenance of location,12/160,315/18670,1.79E-05,0.000110808,5.19E-05,PPARG/AKT1/BAX/NFKBIA/HSPA5/CAV1/IL1B/CXCL11/PPARA/PPARD/CXCL10/HK2,12
BP,GO:0010888,negative regulation of lipid storage,4/160,19/18670,1.82E-05,0.000111481,5.22E-05,PPARG/NFKBIA/PPARA/PPARD,4
BP,GO:0033189,response to vitamin A,4/160,19/18670,1.82E-05,0.000111481,5.22E-05,PPARG/CYP1A1/PPARD/CAT,4
BP,GO:0060149,negative regulation of posttranscriptional gene silencing,4/160,19/18670,1.82E-05,0.000111481,5.22E-05,ESR1/PPARG/TP53/PPP3CA,4
BP,GO:0060967,negative regulation of gene silencing by RNA,4/160,19/18670,1.82E-05,0.000111481,5.22E-05,ESR1/PPARG/TP53/PPP3CA,4
BP,GO:1902176,negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway,4/160,19/18670,1.82E-05,0.000111481,5.22E-05,AKT1/HIF1A/HSPB1/NFE2L2,4
BP,GO:1903798,regulation of production of miRNAs involved in gene silencing by miRNA,4/160,19/18670,1.82E-05,0.000111481,5.22E-05,ESR1/TP53/EGFR/PPP3CA,4
BP,GO:0003158,endothelium development,8/160,132/18670,1.83E-05,0.000111618,5.23E-05,KDR/VEGFA/GJA1/ICAM1/IL1B/CXCL10/MET/IKBKB,8
BP,GO:0043280,positive regulation of cysteine-type endopeptidase activity involved in apoptotic process,8/160,132/18670,1.83E-05,0.000111618,5.23E-05,PPARG/BAX/CASP9/CASP8/MYC/F3/CTSD/CASP1,8
BP,GO:0048010,vascular endothelial growth factor receptor signaling pathway,7/160,96/18670,1.87E-05,0.000113909,5.34E-05,MAPK14/KDR/VEGFA/HIF1A/IL1B/HSPB1/NCF1,7
BP,GO:0097327,response to antineoplastic agent,7/160,96/18670,1.87E-05,0.000113909,5.34E-05,CASP9/F7/EGFR/HMOX1/ICAM1/NR3C1/CDK4,7
BP,GO:0055076,transition metal ion homeostasis,8/160,133/18670,1.93E-05,0.00011737,5.50E-05,SOD1/HIF1A/HMOX1/MYC/IFNG/ABCG2/APP/XIAP,8
BP,GO:0072511,divalent inorganic cation transport,15/160,486/18670,1.95E-05,0.000118073,5.53E-05,PTGS2/BCL2/BAX/CCL2/OPRM1/ADRA2A/EGF/CAV1/GJA1/ICAM1/NOS3/CXCL11/CXCL10/G6PD/PPP3CA,15
BP,GO:0120162,positive regulation of cold-induced thermogenesis,7/160,97/18670,2.00E-05,0.000121341,5.69E-05,ADRB2/ACHE/ADRB1/IL4/VEGFA/CAV1/GJA1,7
BP,GO:0001933,negative regulation of protein phosphorylation,14/160,429/18670,2.02E-05,0.000122246,5.73E-05,AKT1/CDKN1A/BAX/JUN/CASP3/RB1/CAV1/MYC/IL1B/HSPB1/CCNB1/IFNG/GSTP1/IGFBP3,14
BP,GO:0007006,mitochondrial membrane organization,8/160,134/18670,2.04E-05,0.000122761,5.75E-05,BCL2/BAX/TP53/CASP8/BCL2L1/E2F1/HK2/MAPK8,8
BP,GO:0048565,digestive tract development,8/160,134/18670,2.04E-05,0.000122761,5.75E-05,BCL2/CDKN1A/CXCL8/EGFR/RB1/HIF1A/CYP1A1/CCNB1,8
BP,GO:0022898,regulation of transmembrane transporter activity,11/160,268/18670,2.04E-05,0.000122761,5.75E-05,ADRB2/BCL2/CCL2/OPRM1/ADRA2A/HTR3A/MMP9/CAV1/GJA1/IFNG/APP,11
BP,GO:0050714,positive regulation of protein secretion,11/160,268/18670,2.04E-05,0.000122761,5.75E-05,MAPK14/ACHE/EGFR/HIF1A/GJA1/IL1B/IFNG/IL1A/PPARD/CHUK/CASP1,11
BP,GO:0045807,positive regulation of endocytosis,7/160,98/18670,2.14E-05,0.000127843,5.99E-05,PPARG/IL4/VEGFA/EGF/SELE/SERPINE1/PPP3CA,7
BP,GO:0019748,secondary metabolic process,6/160,66/18670,2.14E-05,0.000127843,5.99E-05,BCL2/CYP1A2/CYP1A1/CYP1B1/NFE2L2/TYR,6
BP,GO:0045428,regulation of nitric oxide biosynthetic process,6/160,66/18670,2.14E-05,0.000127843,5.99E-05,PTGS2/AKT1/CAV1/ICAM1/IL1B/IFNG,6
BP,GO:1902108,regulation of mitochondrial membrane permeability involved in apoptotic process,6/160,66/18670,2.14E-05,0.000127843,5.99E-05,BCL2/BAX/TP53/CASP8/E2F1/MAPK8,6
BP,GO:1905710,positive regulation of membrane permeability,6/160,66/18670,2.14E-05,0.000127843,5.99E-05,BCL2/BAX/TP53/CASP8/E2F1/MAPK8,6
BP,GO:0001889,liver development,8/160,135/18670,2.15E-05,0.000128253,6.01E-05,RELA/CCND1/JUN/EGFR/HMOX1/CYP1A1/MET/UGT1A1,8
BP,GO:0060562,epithelial tube morphogenesis,12/160,322/18670,2.23E-05,0.000132549,6.21E-05,ESR1/AR/BCL2/CASP3/PGR/VEGFA/EGF/HIF1A/MYC/GJA1/CXCL10/MET,12
BP,GO:0019373,epoxygenase P450 pathway,4/160,20/18670,2.26E-05,0.000134315,6.29E-05,CYP1A2/CYP2B6/CYP1A1/CYP1B1,4
BP,GO:0072655,establishment of protein localization to mitochondrion,8/160,137/18670,2.39E-05,0.000142012,6.65E-05,AKT1/BCL2/BAX/TP53/CASP8/E2F1/HK2/MAPK8,8
BP,GO:0055024,regulation of cardiac muscle tissue development,7/160,100/18670,2.44E-05,0.000144709,6.78E-05,MAPK14/MAPK1/GJA1/CCNB1/PPARA/ERBB3/G6PD,7
BP,GO:0001649,osteoblast differentiation,10/160,225/18670,2.49E-05,0.000147361,6.91E-05,AKT1/IL6R/ACHE/GJA1/COL1A1/SPP1/RUNX2/IGFBP3/IGF2/CAT,10
BP,GO:0008584,male gonad development,8/160,138/18670,2.52E-05,0.000148785,6.97E-05,ESR1/AR/CCND1/BCL2/BAX/BCL2L1/GJA1/ICAM1,8
BP,GO:0061008,hepaticobiliary system development,8/160,138/18670,2.52E-05,0.000148785,6.97E-05,RELA/CCND1/JUN/EGFR/HMOX1/CYP1A1/MET/UGT1A1,8
BP,GO:0050873,brown fat cell differentiation,5/160,41/18670,2.54E-05,0.000149069,6.99E-05,PTGS2/MAPK14/ADRB2/ADRB1/SLC2A4,5
BP,GO:0150077,regulation of neuroinflammatory response,5/160,41/18670,2.54E-05,0.000149069,6.99E-05,PTGS2/MMP9/IL4/MMP3/IL1B,5
BP,GO:0019915,lipid storage,6/160,68/18670,2.55E-05,0.000149401,7.00E-05,PPARG/NFKBIA/CAV1/IL1B/PPARA/PPARD,6
BP,GO:0032611,interleukin-1 beta production,7/160,101/18670,2.61E-05,0.000152796,7.16E-05,CASP8/IL1B/HSPB1/IFNG/GSTP1/APP/CASP1,7
BP,GO:0046546,development of primary male sexual characteristics,8/160,139/18670,2.66E-05,0.000155551,7.29E-05,ESR1/AR/CCND1/BCL2/BAX/BCL2L1/GJA1/ICAM1,8
BP,GO:0048015,phosphatidylinositol-mediated signaling,9/160,181/18670,2.66E-05,0.000155551,7.29E-05,AKT1/KDR/EGFR/MAPK1/ERBB2/NCF1/PPARD/ERBB3/CAT,9
BP,GO:0036499,PERK-mediated unfolded protein response,4/160,21/18670,2.78E-05,0.000161695,7.58E-05,CCL2/CXCL8/HSPA5/NFE2L2,4
BP,GO:0070920,regulation of production of small RNA involved in gene silencing by RNA,4/160,21/18670,2.78E-05,0.000161695,7.58E-05,ESR1/TP53/EGFR/PPP3CA,4
BP,GO:0061138,morphogenesis of a branching epithelium,9/160,182/18670,2.78E-05,0.00016175,7.58E-05,ESR1/AR/RXRA/BCL2/PGR/VEGFA/EGF/MYC/MET,9
BP,GO:0001822,kidney development,11/160,278/18670,2.86E-05,0.000166264,7.79E-05,BCL2/BAX/CASP9/IL6R/CA2/MMP9/VEGFA/ODC1/STAT1/MYC/CAT,11
BP,GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling,9/160,183/18670,2.90E-05,0.000168396,7.89E-05,RELA/AKT1/CASP8/HMOX1/GJA1/IL1B/CHUK/IKBKB/CASP1,9
BP,GO:0070585,protein localization to mitochondrion,8/160,141/18670,2.95E-05,0.000170692,8.00E-05,AKT1/BCL2/BAX/TP53/CASP8/E2F1/HK2/MAPK8,8
BP,GO:0060485,mesenchyme development,11/160,279/18670,2.96E-05,0.00017108,8.02E-05,BCL2/FN1/MAPK1/HIF1A/STAT1/MYC/IL1B/NOS3/COL1A1/ERBB3/MDM2,11
BP,GO:0044282,small molecule catabolic process,14/160,445/18670,3.02E-05,0.000174676,8.19E-05,NOS2/AKT1/TP53/PON1/CYP1A1/NOS3/SULT1E1/PPARA/PPARD/HK2/CD44/ACOX1/EHHADH/HADHB,14
BP,GO:0048017,inositol lipid-mediated signaling,9/160,184/18670,3.03E-05,0.000174761,8.19E-05,AKT1/KDR/EGFR/MAPK1/ERBB2/NCF1/PPARD/ERBB3/CAT,9
BP,GO:0046822,regulation of nucleocytoplasmic transport,7/160,104/18670,3.15E-05,0.000181265,8.49E-05,PTGS2/MAPK14/TP53/MAPK1/IL1B/IFNG/MDM2,7
BP,GO:0071887,leukocyte apoptotic process,7/160,104/18670,3.15E-05,0.000181265,8.49E-05,AKT1/BAX/CASP9/CASP3/TP53/HIF1A/IL2RA,7
BP,GO:0030336,negative regulation of cell migration,12/160,334/18670,3.19E-05,0.000183171,8.58E-05,PPARG/AKT1/BCL2/CCL2/IL4/HMOX1/CYP1B1/SERPINE1/GSTP1/NFE2L2/PPARD/IGFBP3,12
BP,GO:0006775,fat-soluble vitamin metabolic process,5/160,43/18670,3.21E-05,0.000183465,8.60E-05,CYP3A4/CYP1A1/IL1B/IFNG/PPARD,5
BP,GO:0045429,positive regulation of nitric oxide biosynthetic process,5/160,43/18670,3.21E-05,0.000183465,8.60E-05,PTGS2/AKT1/ICAM1/IL1B/IFNG,5
BP,GO:0071364,cellular response to epidermal growth factor stimulus,5/160,43/18670,3.21E-05,0.000183465,8.60E-05,AKT1/EGFR/ERBB2/COL1A1/GSTP1,5
BP,GO:1904646,cellular response to amyloid-beta,5/160,43/18670,3.21E-05,0.000183465,8.60E-05,ADRB2/ICAM1/VCAM1/PARP1/APP,5
BP,GO:0106106,cold-induced thermogenesis,8/160,143/18670,3.26E-05,0.000185633,8.70E-05,ADRB2/ACHE/ADRB1/IL4/VEGFA/RB1/CAV1/GJA1,8
BP,GO:0120161,regulation of cold-induced thermogenesis,8/160,143/18670,3.26E-05,0.000185633,8.70E-05,ADRB2/ACHE/ADRB1/IL4/VEGFA/RB1/CAV1/GJA1,8
BP,GO:0048738,cardiac muscle tissue development,10/160,233/18670,3.36E-05,0.000190758,8.94E-05,RXRA/MAPK14/VEGFA/MAPK1/GJA1/CCNB1/PPARA/ERBB3/G6PD/MAP2K4,10
BP,GO:0010869,regulation of receptor biosynthetic process,4/160,22/18670,3.37E-05,0.000190758,8.94E-05,PPARG/HIF1A/IFNG/PPARA,4
BP,GO:0031281,positive regulation of cyclase activity,4/160,22/18670,3.37E-05,0.000190758,8.94E-05,NOS2/MAPK14/NOS3/MAPK8,4
BP,GO:0042359,vitamin D metabolic process,4/160,22/18670,3.37E-05,0.000190758,8.94E-05,CYP3A4/CYP1A1/IL1B/IFNG,4
BP,GO:0006635,fatty acid beta-oxidation,6/160,72/18670,3.53E-05,0.00019972,9.36E-05,AKT1/PPARA/PPARD/ACOX1/EHHADH/HADHB,6
BP,GO:0034976,response to endoplasmic reticulum stress,11/160,285/18670,3.59E-05,0.000202457,9.49E-05,CCND1/BCL2/BAX/JUN/TP53/CCL2/CXCL8/BCL2L1/HSPA5/CAV1/NFE2L2,11
BP,GO:0051348,negative regulation of transferase activity,11/160,285/18670,3.59E-05,0.000202457,9.49E-05,PPARG/AKT1/CDKN1A/CASP3/TP53/RB1/CAV1/IL1B/HSPB1/IFNG/GSTP1,11
BP,GO:1904407,positive regulation of nitric oxide metabolic process,5/160,44/18670,3.60E-05,0.000202457,9.49E-05,PTGS2/AKT1/ICAM1/IL1B/IFNG,5
BP,GO:0071901,negative regulation of protein serine/threonine kinase activity,8/160,145/18670,3.60E-05,0.000202457,9.49E-05,AKT1/CDKN1A/CASP3/RB1/CAV1/IL1B/HSPB1/GSTP1,8
BP,GO:0015980,energy derivation by oxidation of organic compounds,11/160,286/18670,3.71E-05,0.000208199,9.76E-05,NOS2/AKT1/TP53/CYP1A2/IL4/HIF1A/MYC/CCNB1/IFNG/IGF2/CAT,11
BP,GO:0043502,regulation of muscle adaptation,7/160,107/18670,3.79E-05,0.000212292,9.95E-05,SCN5A/PRKCA/NOS3/PARP1/PPARA/G6PD/PPP3CA,7
BP,GO:0002793,positive regulation of peptide secretion,11/160,288/18670,3.95E-05,0.0002212,0.000103654,MAPK14/ACHE/EGFR/HIF1A/GJA1/IL1B/IFNG/IL1A/PPARD/CHUK/CASP1,11
BP,GO:0051048,negative regulation of secretion,10/160,238/18670,4.02E-05,0.000223607,0.000104781,FN1/OPRM1/ADRA2A/ADRA2C/ADRA2B/EGF/HMOX1/IL1B/ERBB3/PPP3CA,10
BP,GO:0006275,regulation of DNA replication,7/160,108/18670,4.02E-05,0.000223607,0.000104781,CDK2/JUN/TP53/CCNA2/EGFR/CHEK2/MAP2K4,7
BP,GO:1904659,glucose transmembrane transport,7/160,108/18670,4.02E-05,0.000223607,0.000104781,MAPK14/AKT1/IL1B/NFE2L2/SLC2A4/PPARD/HK2,7
BP,GO:0042771,intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator,5/160,45/18670,4.02E-05,0.000223607,0.000104781,BCL2/CDKN1A/TP53/CHEK2/CD44,5
BP,GO:0048538,thymus development,5/160,45/18670,4.02E-05,0.000223607,0.000104781,BCL2/MAPK1/RAF1/SOD1/TYR,5
BP,GO:0071157,negative regulation of cell cycle arrest,4/160,23/18670,4.05E-05,0.000224926,0.000105399,CCND1/CHEK2/CDK4/MDM2,4
BP,GO:0007162,negative regulation of cell adhesion,11/160,289/18670,4.08E-05,0.000226062,0.000105932,AKT1/CASP3/VEGFA/ERBB2/IL2RA/CYP1B1/SERPINE1/COL1A1/PPARA/IRF1/ERBB3,11
BP,GO:0031670,cellular response to nutrient,6/160,74/18670,4.13E-05,0.000228332,0.000106995,PPARG/PTGS2/SOD1/HMOX1/COL1A1/MDM2,6
BP,GO:1900182,positive regulation of protein localization to nucleus,6/160,74/18670,4.13E-05,0.000228332,0.000106995,PTGS2/MAPK14/AKT1/MAPK1/IFNG/PARP1,6
BP,GO:0051592,response to calcium ion,8/160,148/18670,4.17E-05,0.000230137,0.000107841,SCN5A/CCND1/JUN/EGFR/FOS/HSPA5/CAV1/PPP3CA,8
BP,GO:0017038,protein import,9/160,192/18670,4.23E-05,0.000233149,0.000109253,PTGS2/MAPK14/AKT1/CDKN1A/TP53/MAPK1/NFKBIA/IFNG/PPP3CA,9
BP,GO:0009267,cellular response to starvation,8/160,149/18670,4.37E-05,0.000240452,0.000112675,BCL2/CDKN1A/JUN/TP53/MAPK1/HSPA5/NFE2L2/MAPK8,8
BP,GO:2001056,positive regulation of cysteine-type endopeptidase activity,8/160,149/18670,4.37E-05,0.000240452,0.000112675,PPARG/BAX/CASP9/CASP8/MYC/F3/CTSD/CASP1,8
BP,GO:0007219,Notch signaling pathway,9/160,193/18670,4.40E-05,0.000241784,0.000113299,AKT1/EGFR/EGF/NFKBIA/STAT1/MYC/NOS3/IL2RA/APP,9
BP,GO:0006984,ER-nucleus signaling pathway,5/160,46/18670,4.48E-05,0.000244732,0.00011468,TP53/CCL2/CXCL8/HSPA5/NFE2L2,5
BP,GO:0022602,ovulation cycle process,5/160,46/18670,4.48E-05,0.000244732,0.00011468,ESR1/CASP3/PGR/HSPA5/NOS3,5
BP,GO:0045776,negative regulation of blood pressure,5/160,46/18670,4.48E-05,0.000244732,0.00011468,NOS2/ADRB2/ADRB1/NOS3/PPARA,5
BP,GO:0060443,mammary gland morphogenesis,5/160,46/18670,4.48E-05,0.000244732,0.00011468,ESR1/AR/BAX/PGR/CAV1,5
BP,GO:0016101,diterpenoid metabolic process,7/160,110/18670,4.52E-05,0.000246332,0.00011543,CYP3A4/CYP1A2/EGFR/CYP1A1/CYP1B1/PPARD/UGT1A1,7
BP,GO:0046916,cellular transition metal ion homeostasis,7/160,110/18670,4.52E-05,0.000246332,0.00011543,SOD1/HIF1A/HMOX1/MYC/IFNG/ABCG2/APP,7
BP,GO:1903532,positive regulation of secretion by cell,13/160,403/18670,4.54E-05,0.000247144,0.000115811,MAPK14/ACHE/SLC6A4/EGFR/HIF1A/GJA1/IL1B/IFNG/IL1A/PPARD/CHUK/SPP1/CASP1,13
BP,GO:0048754,branching morphogenesis of an epithelial tube,8/160,150/18670,4.59E-05,0.000249094,0.000116724,ESR1/AR/BCL2/PGR/VEGFA/EGF/MYC/MET,8
BP,GO:0072001,renal system development,11/160,293/18670,4.62E-05,0.000250501,0.000117384,BCL2/BAX/CASP9/IL6R/CA2/MMP9/VEGFA/ODC1/STAT1/MYC/CAT,11
BP,GO:0009404,toxin metabolic process,4/160,24/18670,4.83E-05,0.000260176,0.000121917,CYP1A2/CYP1A1/CYP1B1/NFE2L2,4
BP,GO:0010288,response to lead ion,4/160,24/18670,4.83E-05,0.000260176,0.000121917,PTGS2/CDK4/APP/CAT,4
BP,GO:0042738,exogenous drug catabolic process,4/160,24/18670,4.83E-05,0.000260176,0.000121917,CYP3A4/CYP1A2/CYP2B6/NR1I2,4
BP,GO:2000209,regulation of anoikis,4/160,24/18670,4.83E-05,0.000260176,0.000121917,BCL2/MCL1/CAV1/CHEK2,4
BP,GO:2001026,regulation of endothelial cell chemotaxis,4/160,24/18670,4.83E-05,0.000260176,0.000121917,KDR/VEGFA/HSPB1/MET,4
BP,GO:2000146,negative regulation of cell motility,12/160,349/18670,4.88E-05,0.000262672,0.000123087,PPARG/AKT1/BCL2/CCL2/IL4/HMOX1/CYP1B1/SERPINE1/GSTP1/NFE2L2/PPARD/IGFBP3,12
BP,GO:0031334,positive regulation of protein-containing complex assembly,10/160,244/18670,4.96E-05,0.000266174,0.000124728,ESR1/BAX/TP53/MMP1/MMP3/VEGFA/ICAM1/IFNG/PARP1/MET,10
BP,GO:0001763,morphogenesis of a branching structure,9/160,196/18670,4.96E-05,0.000266174,0.000124728,ESR1/AR/RXRA/BCL2/PGR/VEGFA/EGF/MYC/MET,9
BP,GO:0030574,collagen catabolic process,5/160,47/18670,4.98E-05,0.000266174,0.000124728,MMP1/MMP2/MMP9/MMP3/CTSD,5
BP,GO:0070231,T cell apoptotic process,5/160,47/18670,4.98E-05,0.000266174,0.000124728,AKT1/BAX/TP53/HIF1A/IL2RA,5
BP,GO:1903580,positive regulation of ATP metabolic process,5/160,47/18670,4.98E-05,0.000266174,0.000124728,IL4/HIF1A/CCNB1/IFNG/APP,5
BP,GO:0000187,activation of MAPK activity,8/160,152/18670,5.04E-05,0.000268207,0.000125681,MAPK14/ADRA2B/MAPK1/EGF/SOD1/IL1B/CD40LG/MAP2K4,8
BP,GO:0016202,regulation of striated muscle tissue development,8/160,152/18670,5.04E-05,0.000268207,0.000125681,MAPK14/BCL2/MAPK1/GJA1/CCNB1/PPARA/ERBB3/G6PD,8
BP,GO:0034250,positive regulation of cellular amide metabolic process,8/160,152/18670,5.04E-05,0.000268207,0.000125681,RXRA/CASP3/MAPK1/ERBB2/IFNG/NFE2L2/CDK4/APP,8
BP,GO:0008645,hexose transmembrane transport,7/160,112/18670,5.08E-05,0.000269853,0.000126452,MAPK14/AKT1/IL1B/NFE2L2/SLC2A4/PPARD/HK2,7
BP,GO:0051052,regulation of DNA metabolic process,12/160,351/18670,5.16E-05,0.000273822,0.000128312,PPARG/CDK2/AKT1/CDKN1A/BAX/TP53/IL4/EGFR/MAPK1/MYC/GJA1/PARP1,12
BP,GO:0002221,pattern recognition receptor signaling pathway,9/160,197/18670,5.16E-05,0.000273822,0.000128312,ESR1/RELA/CASP8/NFKBIA/CAV1/CHUK/IRF1/XIAP/IKBKB,9
BP,GO:0030098,lymphocyte differentiation,12/160,353/18670,5.45E-05,0.000288441,0.000135162,BCL2/BAX/TP53/IL4/SOD1/ERBB2/VCAM1/IL2RA/IFNG/RUNX2/CD40LG/IRF1,12
BP,GO:0046850,regulation of bone remodeling,5/160,48/18670,5.52E-05,0.000291524,0.000136607,PRKCA/CA2/EGFR/GJA1/SPP1,5
BP,GO:0090199,regulation of release of cytochrome c from mitochondria,5/160,48/18670,5.52E-05,0.000291524,0.000136607,AKT1/BAX/TP53/MMP9/BCL2L1,5
BP,GO:1990845,adaptive thermogenesis,8/160,154/18670,5.53E-05,0.000291524,0.000136607,ADRB2/ACHE/ADRB1/IL4/VEGFA/RB1/CAV1/GJA1,8
BP,GO:0055021,regulation of cardiac muscle tissue growth,6/160,78/18670,5.57E-05,0.00029321,0.000137397,MAPK14/MAPK1/GJA1/CCNB1/PPARA/G6PD,6
BP,GO:0006109,regulation of carbohydrate metabolic process,9/160,199/18670,5.59E-05,0.000293783,0.000137666,AKT1/TP53/EGF/HIF1A/IFNG/PPARA/IGFBP3/IGF2/APP,9
BP,GO:0015749,monosaccharide transmembrane transport,7/160,114/18670,5.68E-05,0.000298187,0.000139729,MAPK14/AKT1/IL1B/NFE2L2/SLC2A4/PPARD/HK2,7
BP,GO:0030218,erythrocyte differentiation,7/160,114/18670,5.68E-05,0.000298187,0.000139729,MAPK14/CASP3/VEGFA/RB1/HIF1A/STAT1/G6PD,7
BP,GO:0032461,positive regulation of protein oligomerization,4/160,25/18670,5.71E-05,0.000298824,0.000140028,BAX/TP53/MMP1/MMP3,4
BP,GO:1904385,cellular response to angiotensin,4/160,25/18670,5.71E-05,0.000298824,0.000140028,RELA/CA2/CAV1/NFE2L2,4
BP,GO:1901861,regulation of muscle tissue development,8/160,155/18670,5.79E-05,0.000302392,0.0001417,MAPK14/BCL2/MAPK1/GJA1/CCNB1/PPARA/ERBB3/G6PD,8
BP,GO:0050769,positive regulation of neurogenesis,14/160,474/18670,5.99E-05,0.000312517,0.000146444,PPARG/RELA/BCL2/FN1/OPRM1/ADRA2C/ADRA2B/VEGFA/HIF1A/HSPA5/IL1B/IFNG/NFE2L2/E2F1,14
BP,GO:0032612,interleukin-1 production,7/160,115/18670,6.01E-05,0.000313203,0.000146765,CASP8/IL1B/HSPB1/IFNG/GSTP1/APP/CASP1,7
BP,GO:0034767,positive regulation of ion transmembrane transport,8/160,156/18670,6.06E-05,0.000314804,0.000147516,ADRB2/BAX/CCL2/HTR3A/IFNG/CXCL11/CXCL10/G6PD,8
BP,GO:0048634,regulation of muscle organ development,8/160,156/18670,6.06E-05,0.000314804,0.000147516,MAPK14/BCL2/MAPK1/GJA1/CCNB1/PPARA/ERBB3/G6PD,8
BP,GO:0003254,regulation of membrane depolarization,5/160,49/18670,6.11E-05,0.000317043,0.000148565,SCN5A/BCL2/KDR/GJA1/PARP1,5
BP,GO:0009746,response to hexose,9/160,202/18670,6.27E-05,0.000324683,0.000152145,PTGS2/CASP3/ADRA2A/RAF1/HIF1A/GJA1/ICAM1/PPARD/PPP3CA,9
BP,GO:0051701,interaction with host,9/160,202/18670,6.27E-05,0.000324683,0.000152145,RXRA/DPP4/CXCL8/CASP8/EGFR/BCL2L1/CAV1/ICAM1/MET,9
BP,GO:0043271,negative regulation of ion transport,8/160,157/18670,6.33E-05,0.000327534,0.000153481,PTGS2/AKT1/BCL2/ADRA2A/MMP9/CAV1/ICAM1/NOS3,8
BP,GO:0021782,glial cell development,7/160,116/18670,6.35E-05,0.000327534,0.000153481,AKT1/EGFR/SOD1/IL1B/IFNG/GSTP1/APP,7
BP,GO:0034219,carbohydrate transmembrane transport,7/160,116/18670,6.35E-05,0.000327534,0.000153481,MAPK14/AKT1/IL1B/NFE2L2/SLC2A4/PPARD/HK2,7
BP,GO:2000027,regulation of animal organ morphogenesis,10/160,253/18670,6.72E-05,0.000345987,0.000162128,ESR1/AR/RXRA/BCL2/BAX/VEGFA/POR/STAT1/MYC/RUNX2,10
BP,GO:1900087,positive regulation of G1/S transition of mitotic cell cycle,5/160,50/18670,6.74E-05,0.000346702,0.000162463,AKT1/CCND1/EGFR/CYP1A1/MDM2,5
BP,GO:0006006,glucose metabolic process,9/160,204/18670,6.76E-05,0.000347606,0.000162887,MAPK14/AKT1/TP53/PPARA/PPARD/IGFBP3/IGF2/HK2/G6PD,9
BP,GO:0014855,striated muscle cell proliferation,6/160,81/18670,6.89E-05,0.000352984,0.000165407,RXRA/MAPK14/MAPK1/GJA1/CCNB1/PPARD,6
BP,GO:0055072,iron ion homeostasis,6/160,81/18670,6.89E-05,0.000352984,0.000165407,SOD1/HIF1A/HMOX1/MYC/IFNG/ABCG2,6
BP,GO:0001654,eye development,12/160,362/18670,6.93E-05,0.000354775,0.000166246,RXRA/BCL2/BAX/JUN/ACHE/EGFR/VEGFA/HIF1A/GJA1/CYP1A1/CYP1B1/CDK4,12
BP,GO:0030100,regulation of endocytosis,9/160,205/18670,7.02E-05,0.000359094,0.00016827,PPARG/IL4/VEGFA/EGF/CAV1/SELE/SERPINE1/SLC2A4/PPP3CA,9
BP,GO:0001660,fever generation,3/160,10/18670,7.09E-05,0.000360277,0.000168824,PTGS2/IL1B/IL1A,3
BP,GO:0032025,response to cobalt ion,3/160,10/18670,7.09E-05,0.000360277,0.000168824,CASP9/CASP3/CASP8,3
BP,GO:0033483,gas homeostasis,3/160,10/18670,7.09E-05,0.000360277,0.000168824,HIF1A/CAV1/GSTP1,3
BP,GO:0045741,positive regulation of epidermal growth factor-activated receptor activity,3/160,10/18670,7.09E-05,0.000360277,0.000168824,ADRA2A/EGF/NCF1,3
BP,GO:1903799,negative regulation of production of miRNAs involved in gene silencing by miRNA,3/160,10/18670,7.09E-05,0.000360277,0.000168824,ESR1/TP53/PPP3CA,3
BP,GO:0046661,male sex differentiation,8/160,160/18670,7.24E-05,0.000367204,0.00017207,ESR1/AR/CCND1/BCL2/BAX/BCL2L1/GJA1/ICAM1,8
BP,GO:0048260,positive regulation of receptor-mediated endocytosis,5/160,51/18670,7.42E-05,0.000375947,0.000176167,IL4/VEGFA/EGF/SELE/SERPINE1,5
BP,GO:0007173,epidermal growth factor receptor signaling pathway,7/160,119/18670,7.47E-05,0.000377852,0.00017706,AKT1/ADRA2A/MMP9/EGFR/EGF/NCF1/APP,7
BP,GO:0150063,visual system development,12/160,366/18670,7.69E-05,0.000388902,0.000182238,RXRA/BCL2/BAX/JUN/ACHE/EGFR/VEGFA/HIF1A/GJA1/CYP1A1/CYP1B1/CDK4,12
BP,GO:0006706,steroid catabolic process,4/160,27/18670,7.82E-05,0.000392161,0.000183765,CYP3A4/CYP1A2/SULT1E1/SPP1,4
BP,GO:0007176,regulation of epidermal growth factor-activated receptor activity,4/160,27/18670,7.82E-05,0.000392161,0.000183765,ADRA2A/EGF/NCF1/APP,4
BP,GO:0010971,positive regulation of G2/M transition of mitotic cell cycle,4/160,27/18670,7.82E-05,0.000392161,0.000183765,CCND1/CCNB1/CDK4/APP,4
BP,GO:0045932,negative regulation of muscle contraction,4/160,27/18670,7.82E-05,0.000392161,0.000183765,PTGS2/ADRB2/ADRA2C/SOD1,4
BP,GO:0046885,regulation of hormone biosynthetic process,4/160,27/18670,7.82E-05,0.000392161,0.000183765,POR/HIF1A/IL1B/IFNG,4
BP,GO:0048143,astrocyte activation,4/160,27/18670,7.82E-05,0.000392161,0.000183765,EGFR/IL1B/IFNG/APP,4
BP,GO:0006721,terpenoid metabolic process,7/160,120/18670,7.87E-05,0.000393923,0.000184591,CYP3A4/CYP1A2/EGFR/CYP1A1/CYP1B1/PPARD/UGT1A1,7
BP,GO:0010508,positive regulation of autophagy,7/160,120/18670,7.87E-05,0.000393923,0.000184591,ADRB2/KDR/IL4/HIF1A/HMOX1/IFNG/HK2,7
BP,GO:0006970,response to osmotic stress,6/160,83/18670,7.90E-05,0.000394682,0.000184946,PTGS2/BAX/CASP3/TP53/EGFR/SLC2A4,6
BP,GO:0032731,positive regulation of interleukin-1 beta production,5/160,52/18670,8.15E-05,0.000406903,0.000190673,CASP8/HSPB1/IFNG/APP/CASP1,5
BP,GO:0031214,biomineral tissue development,8/160,163/18670,8.25E-05,0.00041051,0.000192363,PTGS2/ADRB2/HIF1A/GJA1/NOS3/COL1A1/PPARA/SPP1,8
BP,GO:0110148,biomineralization,8/160,163/18670,8.25E-05,0.00041051,0.000192363,PTGS2/ADRB2/HIF1A/GJA1/NOS3/COL1A1/PPARA/SPP1,8
BP,GO:0043618,regulation of transcription from RNA polymerase II promoter in response to stress,7/160,121/18670,8.30E-05,0.00041256,0.000193324,JUN/TP53/VEGFA/HIF1A/HSPA5/HMOX1/NFE2L2,7
BP,GO:0048568,embryonic organ development,13/160,428/18670,8.36E-05,0.000414903,0.000194422,AKT1/KDR/TP53/CXCL8/CASP8/EGFR/VEGFA/MAPK1/SOD1/HIF1A/GJA1/RUNX2/IGF2,13
BP,GO:0051047,positive regulation of secretion,13/160,428/18670,8.36E-05,0.000414903,0.000194422,MAPK14/ACHE/SLC6A4/EGFR/HIF1A/GJA1/IL1B/IFNG/IL1A/PPARD/CHUK/SPP1/CASP1,13
BP,GO:0060420,regulation of heart growth,6/160,84/18670,8.45E-05,0.000418405,0.000196063,MAPK14/MAPK1/GJA1/CCNB1/PPARA/G6PD,6
BP,GO:0006633,fatty acid biosynthetic process,8/160,164/18670,8.61E-05,0.000425815,0.000199535,PTGS1/PTGS2/LTA4H/CYP3A4/CYP1A2/CYP1A1/IL1B/ALOX5,8
BP,GO:0048880,sensory system development,12/160,371/18670,8.75E-05,0.000432452,0.000202645,RXRA/BCL2/BAX/JUN/ACHE/EGFR/VEGFA/HIF1A/GJA1/CYP1A1/CYP1B1/CDK4,12
BP,GO:0030195,negative regulation of blood coagulation,5/160,53/18670,8.94E-05,0.000440708,0.000206514,PLAU/NOS3/PLAT/THBD/SERPINE1,5
BP,GO:0045840,positive regulation of mitotic nuclear division,5/160,53/18670,8.94E-05,0.000440708,0.000206514,EGF/RB1/IL1B/IL1A/IGF2,5
BP,GO:0050680,negative regulation of epithelial cell proliferation,8/160,165/18670,8.98E-05,0.000442114,0.000207173,AR/PPARG/CCL2/RB1/STAT1/CAV1/GJA1/PPARD,8
BP,GO:0033598,mammary gland epithelial cell proliferation,4/160,28/18670,9.06E-05,0.000444999,0.000208525,ESR1/CCND1/BAX/MAPK1,4
BP,GO:0042730,fibrinolysis,4/160,28/18670,9.06E-05,0.000444999,0.000208525,PLAU/PLAT/THBD/SERPINE1,4
BP,GO:0071621,granulocyte chemotaxis,7/160,123/18670,9.20E-05,0.000451341,0.000211496,MAPK14/CCL2/CXCL8/IL1B/CXCL11/CXCL2/CXCL10,7
BP,GO:0001776,leukocyte homeostasis,6/160,86/18670,9.63E-05,0.000471351,0.000220873,AKT1/BCL2/BAX/CASP3/HIF1A/IL2RA,6
BP,GO:0006919,activation of cysteine-type endopeptidase activity involved in apoptotic process,6/160,86/18670,9.63E-05,0.000471351,0.000220873,PPARG/BAX/CASP9/CASP8/F3/CASP1,6
BP,GO:0014066,regulation of phosphatidylinositol 3-kinase signaling,7/160,124/18670,9.68E-05,0.000473054,0.000221671,KDR/EGFR/MAPK1/NCF1/PPARD/ERBB3/CAT,7
BP,GO:0043619,regulation of transcription from RNA polymerase II promoter in response to oxidative stress,3/160,11/18670,9.69E-05,0.000473054,0.000221671,HIF1A/HMOX1/NFE2L2,3
BP,GO:0007254,JNK cascade,9/160,214/18670,9.76E-05,0.000474168,0.000222193,AKT1/EGFR/IL1B/NCF1/GSTP1/CD40LG/APP/MAPK8/MAP2K4,9
BP,GO:0045732,positive regulation of protein catabolic process,9/160,214/18670,9.76E-05,0.000474168,0.000222193,AKT1/ADRA2A/EGF/CAV1/GJA1/IL1B/IFNG/NFE2L2/MDM2,9
BP,GO:0032655,regulation of interleukin-12 production,5/160,54/18670,9.78E-05,0.000474168,0.000222193,MAPK14/RELA/IFNG/CD40LG/IRF1,5
BP,GO:0050994,regulation of lipid catabolic process,5/160,54/18670,9.78E-05,0.000474168,0.000222193,AKT1/ADRA2A/IL1B/PPARA/CDK4,5
BP,GO:0051353,positive regulation of oxidoreductase activity,5/160,54/18670,9.78E-05,0.000474168,0.000222193,AKT1/POR/HIF1A/IL1B/IFNG,5
BP,GO:1900047,negative regulation of hemostasis,5/160,54/18670,9.78E-05,0.000474168,0.000222193,PLAU/NOS3/PLAT/THBD/SERPINE1,5
BP,GO:0043010,camera-type eye development,11/160,319/18670,9.88E-05,0.000478249,0.000224106,RXRA/BAX/JUN/ACHE/EGFR/VEGFA/HIF1A/GJA1/CYP1A1/CYP1B1/CDK4,11
BP,GO:0070374,positive regulation of ERK1 and ERK2 cascade,9/160,215/18670,0.00010113,0.000488442,0.000228882,KDR/JUN/CCL2/OPRM1/PRKCA/EGFR/ICAM1/CD44/APP,9
BP,GO:0042119,neutrophil activation,14/160,498/18670,0.000101154,0.000488442,0.000228882,MAPK14/CXCL8/PLAU/LTA4H/MMP9/MAPK1/ALOX5/MPO/GSTP1/CTSD/HPSE/CD44/SLPI/CAT,14
BP,GO:0032368,regulation of lipid transport,7/160,125/18670,0.00010183,0.000491116,0.000230135,PPARG/AKT1/PON1/EGF/NFKBIA/IL1B/SPP1,7
BP,GO:0001892,embryonic placenta development,6/160,87/18670,0.000102729,0.000493665,0.000231329,AKT1/CASP8/EGFR/MAPK1/HIF1A/IGF2,6
BP,GO:0045844,positive regulation of striated muscle tissue development,6/160,87/18670,0.000102729,0.000493665,0.000231329,MAPK14/BCL2/MAPK1/GJA1/CCNB1/ERBB3,6
BP,GO:0048636,positive regulation of muscle organ development,6/160,87/18670,0.000102729,0.000493665,0.000231329,MAPK14/BCL2/MAPK1/GJA1/CCNB1/ERBB3,6
BP,GO:0007263,nitric oxide mediated signal transduction,4/160,29/18670,0.000104398,0.000501086,0.000234807,NOS2/EGFR/VEGFA/NOS3,4
BP,GO:0050728,negative regulation of inflammatory response,8/160,169/18670,0.000106107,0.000508679,0.000238365,PPARG/IL4/RB1/SOD1/IL2RA/GSTP1/PPARA/PPARD,8
BP,GO:0046456,icosanoid biosynthetic process,5/160,55/18670,0.000106888,0.000511808,0.000239831,PTGS1/PTGS2/LTA4H/IL1B/ALOX5,5
BP,GO:0018107,peptidyl-threonine phosphorylation,7/160,126/18670,0.000107054,0.000511991,0.000239917,AKT1/BCL2/PRKCA/MAPK1/EGF/APP/MAPK8,7
BP,GO:0061097,regulation of protein tyrosine kinase activity,6/160,88/18670,0.000109473,0.000521689,0.000244461,ADRA2A/EGF/CAV1/NCF1/ERBB3/APP,6
BP,GO:0070098,chemokine-mediated signaling pathway,6/160,88/18670,0.000109473,0.000521689,0.000244461,CCL2/CXCL8/HIF1A/CXCL11/CXCL2/CXCL10,6
BP,GO:1901863,positive regulation of muscle tissue development,6/160,88/18670,0.000109473,0.000521689,0.000244461,MAPK14/BCL2/MAPK1/GJA1/CCNB1/ERBB3,6
BP,GO:0006869,lipid transport,12/160,380/18670,0.000109684,0.000522074,0.000244642,NOS2/PPARG/RXRA/AKT1/PON1/EGF/NFKBIA/CAV1/IL1B/PPARA/PPARD/SPP1,12
BP,GO:0040013,negative regulation of locomotion,12/160,381/18670,0.000112423,0.000534476,0.000250453,PPARG/AKT1/BCL2/CCL2/IL4/HMOX1/CYP1B1/SERPINE1/GSTP1/NFE2L2/PPARD/IGFBP3,12
BP,GO:0006749,glutathione metabolic process,5/160,56/18670,0.000116561,0.00055153,0.000258445,SOD1/GSTP1/NFE2L2/GSTM1/G6PD,5
BP,GO:0032615,interleukin-12 production,5/160,56/18670,0.000116561,0.00055153,0.000258445,MAPK14/RELA/IFNG/CD40LG/IRF1,5
BP,GO:0090183,regulation of kidney development,5/160,56/18670,0.000116561,0.00055153,0.000258445,IL6R/MMP9/VEGFA/STAT1/MYC,5
BP,GO:1903202,negative regulation of oxidative stress-induced cell death,5/160,56/18670,0.000116561,0.00055153,0.000258445,AKT1/HIF1A/HSPB1/NFE2L2/MET,5
BP,GO:0002576,platelet degranulation,7/160,128/18670,0.000118156,0.000558414,0.000261671,FN1/VEGFA/EGF/SOD1/SERPINE1/IGF2/APP,7
BP,GO:0001782,B cell homeostasis,4/160,30/18670,0.000119659,0.000563523,0.000264064,BCL2/BAX/CASP3/HIF1A,4
BP,GO:0071549,cellular response to dexamethasone stimulus,4/160,30/18670,0.000119659,0.000563523,0.000264064,CASP9/EGFR/ICAM1/NR3C1,4
BP,GO:1902751,positive regulation of cell cycle G2/M phase transition,4/160,30/18670,0.000119659,0.000563523,0.000264064,CCND1/CCNB1/CDK4/APP,4
BP,GO:0051271,negative regulation of cellular component movement,12/160,384/18670,0.000120996,0.00056915,0.000266701,PPARG/AKT1/BCL2/CCL2/IL4/HMOX1/CYP1B1/SERPINE1/GSTP1/NFE2L2/PPARD/IGFBP3,12
BP,GO:0032651,regulation of interleukin-1 beta production,6/160,90/18670,0.000124015,0.0005813,0.000272395,CASP8/HSPB1/IFNG/GSTP1/APP/CASP1,6
BP,GO:0042475,odontogenesis of dentin-containing tooth,6/160,90/18670,0.000124015,0.0005813,0.000272395,SCN5A/BAX/CA2/SERPINE1/PPARA/RUNX2,6
BP,GO:0046849,bone remodeling,6/160,90/18670,0.000124015,0.0005813,0.000272395,ADRB2/PRKCA/CA2/EGFR/GJA1/SPP1,6
BP,GO:0061448,connective tissue development,10/160,273/18670,0.000125886,0.000589382,0.000276182,MAPK14/RELA/IL6R/POR/HIF1A/COL1A1/PPARD/RUNX2/CD44/CDK4,10
BP,GO:0050819,negative regulation of coagulation,5/160,57/18670,0.000126892,0.000591326,0.000277093,PLAU/NOS3/PLAT/THBD/SERPINE1,5
BP,GO:0071398,cellular response to fatty acid,5/160,57/18670,0.000126892,0.000591326,0.000277093,PPARG/AKT1/CCNB1/E2F1/CDK4,5
BP,GO:1900408,negative regulation of cellular response to oxidative stress,5/160,57/18670,0.000126892,0.000591326,0.000277093,AKT1/HIF1A/HSPB1/NFE2L2/MET,5
BP,GO:1903428,positive regulation of reactive oxygen species biosynthetic process,5/160,57/18670,0.000126892,0.000591326,0.000277093,PTGS2/AKT1/ICAM1/IL1B/IFNG,5
BP,GO:0042368,vitamin D biosynthetic process,3/160,12/18670,0.000128392,0.00059762,0.000280042,CYP3A4/IL1B/IFNG,3
BP,GO:0030518,intracellular steroid hormone receptor signaling pathway,7/160,130/18670,0.000130175,0.000605217,0.000283602,ESR1/AR/PGR/ESR2/RB1/PARP1/NR3C1,7
BP,GO:0016054,organic acid catabolic process,10/160,275/18670,0.000133623,0.000619804,0.000290438,NOS2/AKT1/PON1/NOS3/PPARA/PPARD/CD44/ACOX1/EHHADH/HADHB,10
BP,GO:0046395,carboxylic acid catabolic process,10/160,275/18670,0.000133623,0.000619804,0.000290438,NOS2/AKT1/PON1/NOS3/PPARA/PPARD/CD44/ACOX1/EHHADH/HADHB,10
BP,GO:0035767,endothelial cell chemotaxis,4/160,31/18670,0.000136473,0.000630834,0.000295606,KDR/VEGFA/HSPB1/MET,4
BP,GO:0045737,positive regulation of cyclin-dependent protein serine/threonine kinase activity,4/160,31/18670,0.000136473,0.000630834,0.000295606,AKT1/CCND1/EGFR/CCNB1,4
BP,GO:1902253,regulation of intrinsic apoptotic signaling pathway by p53 class mediator,4/160,31/18670,0.000136473,0.000630834,0.000295606,BCL2/TP53/CD44/MDM2,4
BP,GO:0061900,glial cell activation,5/160,58/18670,0.00013791,0.000636007,0.00029803,JUN/EGFR/IL1B/IFNG/APP,5
BP,GO:1903749,positive regulation of establishment of protein localization to mitochondrion,5/160,58/18670,0.00013791,0.000636007,0.00029803,BCL2/TP53/CASP8/E2F1/MAPK8,5
BP,GO:0007160,cell-matrix adhesion,9/160,225/18670,0.00014269,0.000657294,0.000308005,BCL2/KDR/FN1/PLAU/VEGFA/VCAM1/SERPINE1/HPSE/CD44,9
BP,GO:0042476,odontogenesis,7/160,132/18670,0.000143169,0.000657986,0.00030833,SCN5A/BAX/CA2/SERPINE1/COL1A1/PPARA/RUNX2,7
BP,GO:0045598,regulation of fat cell differentiation,7/160,132/18670,0.000143169,0.000657986,0.00030833,PPARG/PTGS2/MAPK14/AKT1/SULT1E1/PPARD/E2F1,7
BP,GO:0003073,regulation of systemic arterial blood pressure,6/160,93/18670,0.000148658,0.00068243,0.000319784,AR/ADRB2/ADRB1/GJA1/NOS3/ECE1,6
BP,GO:0001885,endothelial cell development,5/160,59/18670,0.000149646,0.000684608,0.000320805,VEGFA/ICAM1/IL1B/MET/IKBKB,5
BP,GO:0032732,positive regulation of interleukin-1 production,5/160,59/18670,0.000149646,0.000684608,0.000320805,CASP8/HSPB1/IFNG/APP/CASP1,5
BP,GO:1902883,negative regulation of response to oxidative stress,5/160,59/18670,0.000149646,0.000684608,0.000320805,AKT1/HIF1A/HSPB1/NFE2L2/MET,5
BP,GO:0010950,positive regulation of endopeptidase activity,8/160,178/18670,0.000151919,0.000694212,0.000325305,PPARG/BAX/CASP9/CASP8/MYC/F3/CTSD/CASP1,8
BP,GO:0042311,vasodilation,4/160,32/18670,0.000154933,0.000707182,0.000331383,ADRB2/ADRB1/SOD1/NOS3,4
BP,GO:0006766,vitamin metabolic process,7/160,134/18670,0.000157195,0.000715874,0.000335456,RXRA/PRSS1/CYP3A4/CYP1A1/IL1B/IFNG/PPARD,7
BP,GO:0018210,peptidyl-threonine modification,7/160,134/18670,0.000157195,0.000715874,0.000335456,AKT1/BCL2/PRKCA/MAPK1/EGF/APP/MAPK8,7
BP,GO:0033013,tetrapyrrole metabolic process,5/160,60/18670,0.00016213,0.000736671,0.000345201,PRSS1/CYP1A2/HMOX1/CYP1A1/UGT1A1,5
BP,GO:1902808,positive regulation of cell cycle G1/S phase transition,5/160,60/18670,0.00016213,0.000736671,0.000345201,AKT1/CCND1/EGFR/CYP1A1/MDM2,5
BP,GO:0010565,regulation of cellular ketone metabolic process,8/160,180/18670,0.000164044,0.000743677,0.000348484,PPARG/PTGS2/AKT1/ODC1/CAV1/IL1B/NQO1/PPARA,8
BP,GO:1901796,regulation of signal transduction by p53 class mediator,8/160,180/18670,0.000164044,0.000743677,0.000348484,MAPK14/CDK2/AKT1/BCL2/TP53/CHEK2/CD44/MDM2,8
BP,GO:0010745,negative regulation of macrophage derived foam cell differentiation,3/160,13/18670,0.00016586,0.000747679,0.000350359,PPARG/NFKBIA/PPARA,3
BP,GO:0090594,inflammatory response to wounding,3/160,13/18670,0.00016586,0.000747679,0.000350359,HIF1A/HMOX1/IL1A,3
BP,GO:1901550,regulation of endothelial cell development,3/160,13/18670,0.00016586,0.000747679,0.000350359,VEGFA/IL1B/IKBKB,3
BP,GO:1902894,negative regulation of pri-miRNA transcription by RNA polymerase II,3/160,13/18670,0.00016586,0.000747679,0.000350359,RELA/PPARA/PPARD,3
BP,GO:1903140,regulation of establishment of endothelial barrier,3/160,13/18670,0.00016586,0.000747679,0.000350359,VEGFA/IL1B/IKBKB,3
BP,GO:0042100,B cell proliferation,6/160,95/18670,0.000167133,0.00075257,0.000352651,BCL2/CDKN1A/BAX/CASP3/IL4/CD40LG,6
BP,GO:0010803,regulation of tumor necrosis factor-mediated signaling pathway,5/160,61/18670,0.000175395,0.000788882,0.000369667,CASP8/GSTP1/CHUK/IKBKB/CASP1,5
BP,GO:0002831,regulation of response to biotic stimulus,12/160,400/18670,0.000176844,0.000793551,0.000371855,PPARG/RELA/PRKCA/RAF1/STAT1/IL1B/IL2RA/IFNG/CHUK/IRF1/XIAP/IKBKB,12
BP,GO:0010660,regulation of muscle cell apoptotic process,6/160,96/18670,0.000177027,0.000793551,0.000371855,PPARG/TP53/HMOX1/IFNG/NFE2L2/MAP2K4,6
BP,GO:0019217,regulation of fatty acid metabolic process,6/160,96/18670,0.000177027,0.000793551,0.000371855,PPARG/PTGS2/AKT1/CAV1/IL1B/PPARA,6
BP,GO:0034605,cellular response to heat,7/160,137/18670,0.000180304,0.000806432,0.000377891,PTGS2/CDKN1A/MAPK1/HSPA5/HMOX1/IL1A/CXCL10,7
BP,GO:0046425,regulation of receptor signaling pathway via JAK-STAT,7/160,137/18670,0.000180304,0.000806432,0.000377891,IL6R/IL4/IL10RA/EGF/CAV1/CYP1B1/IFNG,7
BP,GO:0006913,nucleocytoplasmic transport,11/160,343/18670,0.000186385,0.000832699,0.000390199,PTGS2/MAPK14/AKT1/CDKN1A/TP53/MAPK1/NFKBIA/IL1B/IFNG/MDM2/PPP3CA,11
BP,GO:0015908,fatty acid transport,6/160,97/18670,0.000187378,0.000834345,0.00039097,NOS2/PPARG/AKT1/IL1B/PPARA/PPARD,6
BP,GO:1990868,response to chemokine,6/160,97/18670,0.000187378,0.000834345,0.00039097,CCL2/CXCL8/HIF1A/CXCL11/CXCL2/CXCL10,6
BP,GO:1990869,cellular response to chemokine,6/160,97/18670,0.000187378,0.000834345,0.00039097,CCL2/CXCL8/HIF1A/CXCL11/CXCL2/CXCL10,6
BP,GO:0005996,monosaccharide metabolic process,10/160,287/18670,0.000188988,0.000840576,0.000393891,MAPK14/AKT1/TP53/PPARA/PPARD/IGFBP3/IGF2/HK2/G6PD/UGT1A1,10
BP,GO:0045453,bone resorption,5/160,62/18670,0.000189472,0.000841794,0.000394461,ADRB2/PRKCA/CA2/EGFR/SPP1,5
BP,GO:0010721,negative regulation of cell development,11/160,344/18670,0.000191139,0.000848257,0.00039749,BCL2/TP53/SLC6A4/VEGFA/IL1B/PPARA/SPP1/MDM2/APP/G6PD/PPP3CA,11
BP,GO:0032148,activation of protein kinase B activity,4/160,34/18670,0.000197166,0.000870249,0.000407795,AKT1/ADRA2A/ADRA2C/ADRA2B,4
BP,GO:0042533,tumor necrosis factor biosynthetic process,4/160,34/18670,0.000197166,0.000870249,0.000407795,IL4/HSPB1/IFNG/APP,4
BP,GO:0042534,regulation of tumor necrosis factor biosynthetic process,4/160,34/18670,0.000197166,0.000870249,0.000407795,IL4/HSPB1/IFNG/APP,4
BP,GO:0060969,negative regulation of gene silencing,4/160,34/18670,0.000197166,0.000870249,0.000407795,ESR1/PPARG/TP53/PPP3CA,4
BP,GO:0006720,isoprenoid metabolic process,7/160,139/18670,0.000197181,0.000870249,0.000407795,CYP3A4/CYP1A2/EGFR/CYP1A1/CYP1B1/PPARD/UGT1A1,7
BP,GO:0006469,negative regulation of protein kinase activity,9/160,235/18670,0.000197657,0.000870429,0.00040788,AKT1/CDKN1A/CASP3/RB1/CAV1/IL1B/HSPB1/IFNG/GSTP1,9
BP,GO:0046777,protein autophosphorylation,9/160,235/18670,0.000197657,0.000870429,0.00040788,AKT1/KDR/JUN/EGFR/VEGFA/ERBB2/CAV1/CHEK2/INSRR,9
BP,GO:0046328,regulation of JNK cascade,8/160,185/18670,0.000197881,0.000870457,0.000407893,AKT1/EGFR/IL1B/NCF1/GSTP1/CD40LG/APP/MAP2K4,8
BP,GO:0051169,nuclear transport,11/160,346/18670,0.000200956,0.000883013,0.000413776,PTGS2/MAPK14/AKT1/CDKN1A/TP53/MAPK1/NFKBIA/IL1B/IFNG/MDM2/PPP3CA,11
BP,GO:0060078,regulation of postsynaptic membrane potential,7/160,140/18670,0.000206086,0.000904562,0.000423874,ADRB2/AKT1/CHRM1/OPRM1/ADRB1/APP/PPP3CA,7
BP,GO:0070301,cellular response to hydrogen peroxide,6/160,99/18670,0.000209512,0.000918594,0.000430449,RELA/CYP1B1/NFE2L2/NQO1/MDM2/MET,6
BP,GO:0045651,positive regulation of macrophage differentiation,3/160,14/18670,0.000209769,0.000918713,0.000430505,CASP8/PRKCA/RB1,3
BP,GO:0097530,granulocyte migration,7/160,141/18670,0.000215312,0.000941961,0.000441399,MAPK14/CCL2/CXCL8/IL1B/CXCL11/CXCL2/CXCL10,7
BP,GO:1900449,regulation of glutamate receptor signaling pathway,5/160,64/18670,0.000220196,0.000962278,0.000450919,ADRB2/CCL2/OPRM1/IFNG/APP,5
BP,GO:0070423,nucleotide-binding oligomerization domain containing signaling pathway,4/160,35/18670,0.000221129,0.000964053,0.000451751,RELA/CASP8/NFKBIA/XIAP,4
BP,GO:0010657,muscle cell apoptotic process,6/160,100/18670,0.000221325,0.000964053,0.000451751,PPARG/TP53/HMOX1/IFNG/NFE2L2/MAP2K4,6
BP,GO:0070498,interleukin-1-mediated signaling pathway,6/160,100/18670,0.000221325,0.000964053,0.000451751,RELA/NFKBIA/IL1B/IL1A/CHUK/IKBKB,6
BP,GO:0030217,T cell differentiation,9/160,240/18670,0.000231146,0.001005738,0.000471285,BCL2/TP53/IL4/SOD1/ERBB2/IL2RA/IFNG/RUNX2/IRF1,9
BP,GO:1903426,regulation of reactive oxygen species biosynthetic process,6/160,101/18670,0.000233657,0.001015559,0.000475887,PTGS2/AKT1/CAV1/ICAM1/IL1B/IFNG,6
BP,GO:0072678,T cell migration,5/160,65/18670,0.000236911,0.001028585,0.000481991,CCL2/ICAM1/CXCL11/CXCL10/APP,5
BP,GO:0038093,Fc receptor signaling pathway,9/160,241/18670,0.00023838,0.001032722,0.000483929,RELA/JUN/FOS/MAPK1/CHUK/IKBKB/MAPK8/PPP3CA/MAP2K4,9
BP,GO:0042593,glucose homeostasis,9/160,241/18670,0.00023838,0.001032722,0.000483929,PPARG/AKT1/ADRA2A/RAF1/HIF1A/ICAM1/SLC2A4/HK2/PPP3CA,9
BP,GO:0050890,cognition,10/160,296/18670,0.000242201,0.001048143,0.000491155,PTGS2/JUN/CASP3/CHRM1/SLC6A4/EGFR/FOS/MAPK1/HIF1A/APP,10
BP,GO:0031589,cell-substrate adhesion,11/160,354/18670,0.000244616,0.001053483,0.000493658,BCL2/KDR/FN1/PLAU/VEGFA/VCAM1/SERPINE1/COL1A1/PPARD/HPSE/CD44,11
BP,GO:1904064,positive regulation of cation transmembrane transport,7/160,144/18670,0.000245009,0.001053483,0.000493658,ADRB2/BAX/CCL2/IFNG/CXCL11/CXCL10/G6PD,7
BP,GO:0033500,carbohydrate homeostasis,9/160,242/18670,0.0002458,0.001053483,0.000493658,PPARG/AKT1/ADRA2A/RAF1/HIF1A/ICAM1/SLC2A4/HK2/PPP3CA,9
BP,GO:0051054,positive regulation of DNA metabolic process,8/160,191/18670,0.000245851,0.001053483,0.000493658,CDK2/AKT1/BAX/IL4/EGFR/MAPK1/MYC/PARP1,8
BP,GO:0010742,macrophage derived foam cell differentiation,4/160,36/18670,0.00024712,0.001053483,0.000493658,PPARG/NFKBIA/STAT1/PPARA,4
BP,GO:0030224,monocyte differentiation,4/160,36/18670,0.00024712,0.001053483,0.000493658,PPARG/JUN/VEGFA/MYC,4
BP,GO:0035872,"nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway",4/160,36/18670,0.00024712,0.001053483,0.000493658,RELA/CASP8/NFKBIA/XIAP,4
BP,GO:0042554,superoxide anion generation,4/160,36/18670,0.00024712,0.001053483,0.000493658,EGFR/SOD1/NCF1/GSTP1,4
BP,GO:0045740,positive regulation of DNA replication,4/160,36/18670,0.00024712,0.001053483,0.000493658,CDK2/JUN/EGFR/MAP2K4,4
BP,GO:0071392,cellular response to estradiol stimulus,4/160,36/18670,0.00024712,0.001053483,0.000493658,ESR1/CCNA2/EGFR/UGT1A1,4
BP,GO:0090077,foam cell differentiation,4/160,36/18670,0.00024712,0.001053483,0.000493658,PPARG/NFKBIA/STAT1/PPARA,4
BP,GO:0090322,regulation of superoxide metabolic process,4/160,36/18670,0.00024712,0.001053483,0.000493658,EGFR/SOD1/GSTP1/NFE2L2,4
BP,GO:1903131,mononuclear cell differentiation,4/160,36/18670,0.00024712,0.001053483,0.000493658,PPARG/JUN/VEGFA/MYC,4
BP,GO:2000310,regulation of NMDA receptor activity,4/160,36/18670,0.00024712,0.001053483,0.000493658,CCL2/OPRM1/IFNG/APP,4
BP,GO:0010876,lipid localization,12/160,415/18670,0.000247923,0.001055781,0.000494735,NOS2/PPARG/RXRA/AKT1/PON1/EGF/NFKBIA/CAV1/IL1B/PPARA/PPARD/SPP1,12
BP,GO:0051785,positive regulation of nuclear division,5/160,66/18670,0.000254574,0.001081803,0.000506928,EGF/RB1/IL1B/IL1A/IGF2,5
BP,GO:0051926,negative regulation of calcium ion transport,5/160,66/18670,0.000254574,0.001081803,0.000506928,PTGS2/BCL2/ADRA2A/ICAM1/NOS3,5
BP,GO:0032652,regulation of interleukin-1 production,6/160,103/18670,0.000259941,0.00109909,0.000515029,CASP8/HSPB1/IFNG/GSTP1/APP/CASP1,6
BP,GO:0009812,flavonoid metabolic process,3/160,15/18670,0.000260564,0.00109909,0.000515029,POR/CYP1A1/UGT1A1,3
BP,GO:0030730,sequestering of triglyceride,3/160,15/18670,0.000260564,0.00109909,0.000515029,PPARG/IL1B/PPARA,3
BP,GO:0033604,negative regulation of catecholamine secretion,3/160,15/18670,0.000260564,0.00109909,0.000515029,ADRA2A/ADRA2C/ADRA2B,3
BP,GO:0035635,entry of bacterium into host cell,3/160,15/18670,0.000260564,0.00109909,0.000515029,CXCL8/CAV1/MET,3
BP,GO:0042362,fat-soluble vitamin biosynthetic process,3/160,15/18670,0.000260564,0.00109909,0.000515029,CYP3A4/IL1B/IFNG,3
BP,GO:0051044,positive regulation of membrane protein ectodomain proteolysis,3/160,15/18670,0.000260564,0.00109909,0.000515029,ADRA2A/IL1B/IFNG,3
BP,GO:0019318,hexose metabolic process,9/160,244/18670,0.000261218,0.00110069,0.000515779,MAPK14/AKT1/TP53/PPARA/PPARD/IGFBP3/IGF2/HK2/G6PD,9
BP,GO:0002224,toll-like receptor signaling pathway,7/160,146/18670,0.000266578,0.001119741,0.000524706,ESR1/CASP8/NFKBIA/CAV1/CHUK/IRF1/IKBKB,7
BP,GO:0045834,positive regulation of lipid metabolic process,7/160,146/18670,0.000266578,0.001119741,0.000524706,PPARG/PTGS2/AKT1/POR/IL1B/IFNG/PPARA,7
BP,GO:1904892,regulation of receptor signaling pathway via STAT,7/160,146/18670,0.000266578,0.001119741,0.000524706,IL6R/IL4/IL10RA/EGF/CAV1/CYP1B1/IFNG,7
BP,GO:0060038,cardiac muscle cell proliferation,5/160,67/18670,0.000273219,0.001141729,0.000535009,RXRA/MAPK14/MAPK1/GJA1/CCNB1,5
BP,GO:0001523,retinoid metabolic process,6/160,104/18670,0.000273926,0.001141729,0.000535009,CYP3A4/CYP1A2/CYP1A1/CYP1B1/PPARD/UGT1A1,6
BP,GO:0030593,neutrophil chemotaxis,6/160,104/18670,0.000273926,0.001141729,0.000535009,CCL2/CXCL8/IL1B/CXCL11/CXCL2/CXCL10,6
BP,GO:0014037,Schwann cell differentiation,4/160,37/18670,0.000275236,0.001141729,0.000535009,RELA/AKT1/SOD1/ERBB3,4
BP,GO:0030212,hyaluronan metabolic process,4/160,37/18670,0.000275236,0.001141729,0.000535009,AKT1/EGF/IL1B/CD44,4
BP,GO:0033280,response to vitamin D,4/160,37/18670,0.000275236,0.001141729,0.000535009,PTGS2/CXCL10/SPP1/TYR,4
BP,GO:0038083,peptidyl-tyrosine autophosphorylation,4/160,37/18670,0.000275236,0.001141729,0.000535009,KDR/EGFR/VEGFA/CAV1,4
BP,GO:0042307,positive regulation of protein import into nucleus,4/160,37/18670,0.000275236,0.001141729,0.000535009,PTGS2/MAPK14/MAPK1/IFNG,4
BP,GO:0045923,positive regulation of fatty acid metabolic process,4/160,37/18670,0.000275236,0.001141729,0.000535009,PPARG/PTGS2/IL1B/PPARA,4
BP,GO:0046006,regulation of activated T cell proliferation,4/160,37/18670,0.000275236,0.001141729,0.000535009,IL6R/CASP3/IL2RA/IGF2,4
BP,GO:0090050,positive regulation of cell migration involved in sprouting angiogenesis,4/160,37/18670,0.000275236,0.001141729,0.000535009,PTGS2/KDR/VEGFA/HMOX1,4
BP,GO:0098926,postsynaptic signal transduction,4/160,37/18670,0.000275236,0.001141729,0.000535009,RELA/CHRM3/CHRM1/OPRM1,4
BP,GO:0042180,cellular ketone metabolic process,9/160,246/18670,0.000277429,0.001149637,0.000538715,PPARG/PTGS2/AKT1/CYP2B6/ODC1/CAV1/IL1B/NQO1/PPARA,9
BP,GO:0043312,neutrophil degranulation,13/160,485/18670,0.000285669,0.001182556,0.000554141,MAPK14/PLAU/LTA4H/MMP9/MAPK1/ALOX5/MPO/GSTP1/CTSD/HPSE/CD44/SLPI/CAT,13
BP,GO:0008643,carbohydrate transport,7/160,148/18670,0.00028965,0.001197798,0.000561283,MAPK14/AKT1/IL1B/NFE2L2/SLC2A4/PPARD/HK2,7
BP,GO:0006694,steroid biosynthetic process,8/160,196/18670,0.000292756,0.001206183,0.000565213,CYP3A4/POR/SOD1/IL1B/IFNG/HSD3B2/HSD3B1/G6PD,8
BP,GO:0016239,positive regulation of macroautophagy,5/160,68/18670,0.000292883,0.001206183,0.000565213,ADRB2/KDR/IL4/HIF1A/HMOX1,5
BP,GO:0033627,cell adhesion mediated by integrin,5/160,68/18670,0.000292883,0.001206183,0.000565213,DPP4/PLAU/ICAM1/CYP1B1/SERPINE1,5
BP,GO:0046323,glucose import,5/160,68/18670,0.000292883,0.001206183,0.000565213,MAPK14/AKT1/NFE2L2/SLC2A4/HK2,5
BP,GO:0009749,response to glucose,8/160,197/18670,0.000302962,0.001244331,0.000583088,CASP3/ADRA2A/RAF1/HIF1A/GJA1/ICAM1/PPARD/PPP3CA,8
BP,GO:0002283,neutrophil activation involved in immune response,13/160,488/18670,0.00030307,0.001244331,0.000583088,MAPK14/PLAU/LTA4H/MMP9/MAPK1/ALOX5/MPO/GSTP1/CTSD/HPSE/CD44/SLPI/CAT,13
BP,GO:0006936,muscle contraction,11/160,363/18670,0.000303078,0.001244331,0.000583088,SCN5A/PTGS2/ADRB2/CHRM3/ADRA2A/ADRA2C/ADRA2B/SOD1/CAV1/GJA1/CHUK,11
BP,GO:0003300,cardiac muscle hypertrophy,6/160,106/18670,0.000303667,0.001245472,0.000583623,PRKCA/PARP1/PPARA/G6PD/PPP3CA/MAP2K4,6
BP,GO:0006778,porphyrin-containing compound metabolic process,4/160,38/18670,0.000305576,0.001248185,0.000584894,CYP1A2/HMOX1/CYP1A1/UGT1A1,4
BP,GO:0007190,activation of adenylate cyclase activity,4/160,38/18670,0.000305576,0.001248185,0.000584894,ADRB2/ADRB1/RAF1/ADCY2,4
BP,GO:0032350,regulation of hormone metabolic process,4/160,38/18670,0.000305576,0.001248185,0.000584894,POR/HIF1A/IL1B/IFNG,4
BP,GO:1904706,negative regulation of vascular smooth muscle cell proliferation,4/160,38/18670,0.000305576,0.001248185,0.000584894,PPARG/CDKN1A/HMOX1/GSTP1,4
BP,GO:0050766,positive regulation of phagocytosis,5/160,69/18670,0.000313602,0.001278358,0.000599033,PPARG/CCL2/SOD1/IL1B/IFNG,5
BP,GO:0070227,lymphocyte apoptotic process,5/160,69/18670,0.000313602,0.001278358,0.000599033,AKT1/BAX/TP53/HIF1A/IL2RA,5
BP,GO:0010885,regulation of cholesterol storage,3/160,16/18670,0.00031868,0.001291171,0.000605038,PPARG/PPARA/PPARD,3
BP,GO:0014061,regulation of norepinephrine secretion,3/160,16/18670,0.00031868,0.001291171,0.000605038,ADRA2A/ADRA2C/ADRA2B,3
BP,GO:0019372,lipoxygenase pathway,3/160,16/18670,0.00031868,0.001291171,0.000605038,PTGS2/PON1/ALOX5,3
BP,GO:0071732,cellular response to nitric oxide,3/160,16/18670,0.00031868,0.001291171,0.000605038,CDK2/CCNA2/MMP3,3
BP,GO:1900451,positive regulation of glutamate receptor signaling pathway,3/160,16/18670,0.00031868,0.001291171,0.000605038,ADRB2/CCL2/IFNG,3
BP,GO:1902004,positive regulation of amyloid-beta formation,3/160,16/18670,0.00031868,0.001291171,0.000605038,CASP3/IFNG/APP,3
BP,GO:0043254,regulation of protein-containing complex assembly,12/160,429/18670,0.000334926,0.00135562,0.000635238,ESR1/BAX/TP53/MMP1/MMP3/VEGFA/RB1/RAF1/ICAM1/IFNG/PARP1/MET,12
BP,GO:0009062,fatty acid catabolic process,6/160,108/18670,0.000335884,0.001356756,0.00063577,AKT1/PPARA/PPARD/ACOX1/EHHADH/HADHB,6
BP,GO:2000278,regulation of DNA biosynthetic process,6/160,108/18670,0.000335884,0.001356756,0.00063577,PPARG/CDKN1A/TP53/MAPK1/MYC/GJA1,6
BP,GO:0010661,positive regulation of muscle cell apoptotic process,4/160,39/18670,0.000338241,0.001363525,0.000638942,PPARG/TP53/IFNG/MAP2K4,4
BP,GO:1904591,positive regulation of protein import,4/160,39/18670,0.000338241,0.001363525,0.000638942,PTGS2/MAPK14/MAPK1/IFNG,4
BP,GO:0031330,negative regulation of cellular catabolic process,9/160,253/18670,0.000340883,0.001372791,0.000643284,MAPK14/AKT1/BCL2/TP53/MCL1/IL10RA/HMOX1/E2F1/MET,9
BP,GO:0014897,striated muscle hypertrophy,6/160,109/18670,0.000352966,0.001417173,0.000664082,PRKCA/PARP1/PPARA/G6PD/PPP3CA/MAP2K4,6
BP,GO:0071868,cellular response to monoamine stimulus,6/160,109/18670,0.000352966,0.001417173,0.000664082,CHRM3/CHRM1/OPRM1/HTR3A/MAPK1/APP,6
BP,GO:0071870,cellular response to catecholamine stimulus,6/160,109/18670,0.000352966,0.001417173,0.000664082,CHRM3/CHRM1/OPRM1/HTR3A/MAPK1/APP,6
BP,GO:0030278,regulation of ossification,8/160,203/18670,0.000370482,0.001486013,0.000696339,MAPK14/ADRB2/BCL2/IL6R/MAPK1/HIF1A/GJA1/RUNX2,8
BP,GO:0007611,learning or memory,9/160,256/18670,0.000371525,0.001488496,0.000697503,PTGS2/JUN/CASP3/SLC6A4/EGFR/FOS/MAPK1/HIF1A/APP,9
BP,GO:0042596,fear response,4/160,40/18670,0.000373332,0.001488496,0.000697503,DPP4/BCL2/ADRB1/GJA1,4
BP,GO:0045124,regulation of bone resorption,4/160,40/18670,0.000373332,0.001488496,0.000697503,PRKCA/CA2/EGFR/SPP1,4
BP,GO:0046621,negative regulation of organ growth,4/160,40/18670,0.000373332,0.001488496,0.000697503,SLC6A4/GJA1/PPARA/G6PD,4
BP,GO:0071548,response to dexamethasone,4/160,40/18670,0.000373332,0.001488496,0.000697503,CASP9/EGFR/ICAM1/NR3C1,4
BP,GO:1900371,regulation of purine nucleotide biosynthetic process,4/160,40/18670,0.000373332,0.001488496,0.000697503,NOS2/IL4/NOS3/PARP1,4
BP,GO:0002446,neutrophil mediated immunity,13/160,499/18670,0.00037485,0.001493059,0.000699641,MAPK14/PLAU/LTA4H/MMP9/MAPK1/ALOX5/MPO/GSTP1/CTSD/HPSE/CD44/SLPI/CAT,13
BP,GO:0002683,negative regulation of immune system process,12/160,435/18670,0.000379465,0.001509937,0.00070755,PPARG/AKT1/CASP3/CCL2/IL4/NFKBIA/ERBB2/HMOX1/MYC/IL2RA/NFE2L2/IRF1,12
BP,GO:0033673,negative regulation of kinase activity,9/160,257/18670,0.000382231,0.001515073,0.000709957,AKT1/CDKN1A/CASP3/RB1/CAV1/IL1B/HSPB1/IFNG/GSTP1,9
BP,GO:1903747,regulation of establishment of protein localization to mitochondrion,5/160,72/18670,0.000382458,0.001515073,0.000709957,BCL2/TP53/CASP8/E2F1/MAPK8,5
BP,GO:0006978,"DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator",3/160,17/18670,0.00038454,0.001515073,0.000709957,CDKN1A/TP53/CHEK2,3
BP,GO:0010224,response to UV-B,3/160,17/18670,0.00038454,0.001515073,0.000709957,RELA/BCL2/CDKN1A,3
BP,GO:0048243,norepinephrine secretion,3/160,17/18670,0.00038454,0.001515073,0.000709957,ADRA2A/ADRA2C/ADRA2B,3
BP,GO:0050665,hydrogen peroxide biosynthetic process,3/160,17/18670,0.00038454,0.001515073,0.000709957,CYP1A2/SOD1/CYP1A1,3
BP,GO:0070242,thymocyte apoptotic process,3/160,17/18670,0.00038454,0.001515073,0.000709957,BAX/TP53/HIF1A,3
BP,GO:1903209,positive regulation of oxidative stress-induced cell death,3/160,17/18670,0.00038454,0.001515073,0.000709957,MCL1/MMP3/SOD1,3
BP,GO:2000811,negative regulation of anoikis,3/160,17/18670,0.00038454,0.001515073,0.000709957,BCL2/MCL1/CAV1,3
BP,GO:2001267,regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway,3/160,17/18670,0.00038454,0.001515073,0.000709957,BAX/CASP8/MMP9,3
BP,GO:0050804,modulation of chemical synaptic transmission,12/160,436/18670,0.000387355,0.001524662,0.00071445,PTGS2/ADRB2/CCL2/ACHE/SLC6A4/CA2/EGFR/MAPK1/IL1B/PLAT/APP/PPP3CA,12
BP,GO:0014896,muscle hypertrophy,6/160,111/18670,0.000389165,0.001527281,0.000715678,PRKCA/PARP1/PPARA/G6PD/PPP3CA/MAP2K4,6
BP,GO:0031623,receptor internalization,6/160,111/18670,0.000389165,0.001527281,0.000715678,CXCL8/ACHE/VEGFA/EGF/CAV1/SELE,6
BP,GO:0072676,lymphocyte migration,6/160,111/18670,0.000389165,0.001527281,0.000715678,AKT1/CCL2/ICAM1/CXCL11/CXCL10/APP,6
BP,GO:0099177,regulation of trans-synaptic signaling,12/160,437/18670,0.000395384,0.001550167,0.000726402,PTGS2/ADRB2/CCL2/ACHE/SLC6A4/CA2/EGFR/MAPK1/IL1B/PLAT/APP/PPP3CA,12
BP,GO:0033555,multicellular organismal response to stress,5/160,73/18670,0.00040777,0.001597167,0.000748426,DPP4/BCL2/ADRB1/GJA1/PPP3CA,5
BP,GO:0030808,regulation of nucleotide biosynthetic process,4/160,41/18670,0.000410951,0.00160335,0.000751323,NOS2/IL4/NOS3/PARP1,4
BP,GO:0042572,retinol metabolic process,4/160,41/18670,0.000410951,0.00160335,0.000751323,CYP3A4/CYP1A2/CYP1A1/CYP1B1,4
BP,GO:0050798,activated T cell proliferation,4/160,41/18670,0.000410951,0.00160335,0.000751323,IL6R/CASP3/IL2RA/IGF2,4
BP,GO:0061028,establishment of endothelial barrier,4/160,41/18670,0.000410951,0.00160335,0.000751323,VEGFA/ICAM1/IL1B/IKBKB,4
BP,GO:0032412,regulation of ion transmembrane transporter activity,9/160,260/18670,0.000415887,0.001621028,0.000759607,ADRB2/CCL2/OPRM1/ADRA2A/HTR3A/MMP9/CAV1/IFNG/APP,9
BP,GO:0071867,response to monoamine,6/160,113/18670,0.000428203,0.00166579,0.000780582,CHRM3/CHRM1/OPRM1/HTR3A/MAPK1/APP,6
BP,GO:0071869,response to catecholamine,6/160,113/18670,0.000428203,0.00166579,0.000780582,CHRM3/CHRM1/OPRM1/HTR3A/MAPK1/APP,6
BP,GO:0099601,regulation of neurotransmitter receptor activity,5/160,74/18670,0.000434326,0.001687969,0.000790975,ADRB2/CCL2/OPRM1/IFNG/APP,5
BP,GO:0045446,endothelial cell differentiation,6/160,114/18670,0.000448835,0.001742663,0.000816605,KDR/VEGFA/ICAM1/IL1B/MET/IKBKB,6
BP,GO:0042149,cellular response to glucose starvation,4/160,42/18670,0.0004512,0.001750148,0.000820112,BCL2/TP53/HSPA5/NFE2L2,4
BP,GO:0007252,I-kappaB phosphorylation,3/160,18/18670,0.000458553,0.001773515,0.000831062,AKT1/CHUK/IKBKB,3
BP,GO:0010878,cholesterol storage,3/160,18/18670,0.000458553,0.001773515,0.000831062,PPARG/PPARA/PPARD,3
BP,GO:0042772,"DNA damage response, signal transduction resulting in transcription",3/160,18/18670,0.000458553,0.001773515,0.000831062,CDKN1A/TP53/CHEK2,3
BP,GO:0007422,peripheral nervous system development,5/160,75/18670,0.000462166,0.00178404,0.000835994,RELA/AKT1/SOD1/ERBB2/ERBB3,5
BP,GO:0010611,regulation of cardiac muscle hypertrophy,5/160,75/18670,0.000462166,0.00178404,0.000835994,PRKCA/PARP1/PPARA/G6PD/PPP3CA,5
BP,GO:0044839,cell cycle G2/M phase transition,9/160,266/18670,0.000490546,0.001888151,0.00088478,CDK2/CCND1/CDKN1A/TP53/CCNA2/CCNB1/CHEK2/CDK4/APP,9
BP,GO:0001937,negative regulation of endothelial cell proliferation,5/160,76/18670,0.000491329,0.001888151,0.00088478,PPARG/CCL2/STAT1/CAV1/GJA1,5
BP,GO:0045454,cell redox homeostasis,5/160,76/18670,0.000491329,0.001888151,0.00088478,NOS2/NOS3/MPO/NCF1/NFE2L2,5
BP,GO:1900180,regulation of protein localization to nucleus,6/160,116/18670,0.000492419,0.001888151,0.00088478,PTGS2/MAPK14/AKT1/MAPK1/IFNG/PARP1,6
BP,GO:0007265,Ras protein signal transduction,12/160,448/18670,0.000493412,0.001888151,0.00088478,MAPK14/CDK2/CDKN1A/JUN/TP53/ADRA2A/CCNA2/RB1/RAF1/CHUK/RASSF1/MET,12
BP,GO:0006692,prostanoid metabolic process,4/160,43/18670,0.000494181,0.001888151,0.00088478,PTGS1/PTGS2/IL1B/ACOX1,4
BP,GO:0006693,prostaglandin metabolic process,4/160,43/18670,0.000494181,0.001888151,0.00088478,PTGS1/PTGS2/IL1B/ACOX1,4
BP,GO:0031279,regulation of cyclase activity,4/160,43/18670,0.000494181,0.001888151,0.00088478,NOS2/MAPK14/NOS3/MAPK8,4
BP,GO:0032459,regulation of protein oligomerization,4/160,43/18670,0.000494181,0.001888151,0.00088478,BAX/TP53/MMP1/MMP3,4
BP,GO:0045746,negative regulation of Notch signaling pathway,4/160,43/18670,0.000494181,0.001888151,0.00088478,AKT1/EGFR/EGF/NFKBIA,4
BP,GO:1903531,negative regulation of secretion by cell,8/160,212/18670,0.000494325,0.001888151,0.00088478,FN1/OPRM1/ADRA2A/ADRA2C/ADRA2B/HMOX1/IL1B/PPP3CA,8
BP,GO:0015718,monocarboxylic acid transport,7/160,163/18670,0.000518622,0.001979068,0.000927383,NOS2/PPARG/RXRA/AKT1/IL1B/PPARA/PPARD,7
BP,GO:0048678,response to axon injury,5/160,77/18670,0.000521855,0.00198951,0.000932276,BCL2/BAX/JUN/SOD1/SPP1,5
BP,GO:1990266,neutrophil migration,6/160,118/18670,0.000539232,0.002043481,0.000957567,CCL2/CXCL8/IL1B/CXCL11/CXCL2/CXCL10,6
BP,GO:0014002,astrocyte development,4/160,44/18670,0.00054,0.002043481,0.000957567,EGFR/IL1B/IFNG/APP,4
BP,GO:0061756,leukocyte adhesion to vascular endothelial cell,4/160,44/18670,0.00054,0.002043481,0.000957567,RELA/ICAM1/SELE/VCAM1,4
BP,GO:0090311,regulation of protein deacetylation,4/160,44/18670,0.00054,0.002043481,0.000957567,TP53/VEGFA/IFNG/MAPK8,4
BP,GO:0007213,G protein-coupled acetylcholine receptor signaling pathway,3/160,19/18670,0.000541117,0.002043481,0.000957567,CHRM3/CHRM1/OPRM1,3
BP,GO:0030949,positive regulation of vascular endothelial growth factor receptor signaling pathway,3/160,19/18670,0.000541117,0.002043481,0.000957567,VEGFA/HIF1A/IL1B,3
BP,GO:0032930,positive regulation of superoxide anion generation,3/160,19/18670,0.000541117,0.002043481,0.000957567,EGFR/SOD1/GSTP1,3
BP,GO:0071731,response to nitric oxide,3/160,19/18670,0.000541117,0.002043481,0.000957567,CDK2/CCNA2/MMP3,3
BP,GO:1900409,positive regulation of cellular response to oxidative stress,3/160,19/18670,0.000541117,0.002043481,0.000957567,MCL1/MMP3/SOD1,3
BP,GO:1902170,cellular response to reactive nitrogen species,3/160,19/18670,0.000541117,0.002043481,0.000957567,CDK2/CCNA2/MMP3,3
BP,GO:0010827,regulation of glucose transmembrane transport,5/160,78/18670,0.000553786,0.002085422,0.00097722,MAPK14/AKT1/IL1B/NFE2L2/HK2,5
BP,GO:0014743,regulation of muscle hypertrophy,5/160,78/18670,0.000553786,0.002085422,0.00097722,PRKCA/PARP1/PPARA/G6PD/PPP3CA,5
BP,GO:0042246,tissue regeneration,5/160,78/18670,0.000553786,0.002085422,0.00097722,CDKN1A/GJA1/CCNB1/PPARD/PPP3CA,5
BP,GO:0032570,response to progesterone,4/160,45/18670,0.000588759,0.00221504,0.001037959,RELA/FOS/CAV1/CLDN4,4
BP,GO:0006260,DNA replication,9/160,273/18670,0.000591232,0.002222254,0.001041339,CDK2/JUN/TP53/ACHE/CCNA2/EGFR/TOP1/CHEK2/MAP2K4,9
BP,GO:0090150,establishment of protein localization to membrane,10/160,332/18670,0.000597258,0.002242798,0.001050966,BCL2/BAX/TP53/CASP8/EGFR/HSPA5/ERBB2/NCF1/E2F1/MAPK8,10
BP,GO:0030968,endoplasmic reticulum unfolded protein response,6/160,121/18670,0.000615859,0.002310482,0.001082682,CCND1/BAX/CCL2/CXCL8/HSPA5/NFE2L2,6
BP,GO:0050806,positive regulation of synaptic transmission,7/160,168/18670,0.000620842,0.002324819,0.001089401,PTGS2/ADRB2/CCL2/CA2/EGFR/MAPK1/APP,7
BP,GO:0051302,regulation of cell division,7/160,168/18670,0.000620842,0.002324819,0.001089401,VEGFA/BCL2L1/MYC/IL1B/IL1A/IGF2/CAT,7
BP,GO:0010042,response to manganese ion,3/160,20/18670,0.000632617,0.002355689,0.001103866,PTGS2/HSPA5/APP,3
BP,GO:0032495,response to muramyl dipeptide,3/160,20/18670,0.000632617,0.002355689,0.001103866,MAPK14/RELA/NFKBIA,3
BP,GO:0034393,positive regulation of smooth muscle cell apoptotic process,3/160,20/18670,0.000632617,0.002355689,0.001103866,PPARG/IFNG/MAP2K4,3
BP,GO:0042535,positive regulation of tumor necrosis factor biosynthetic process,3/160,20/18670,0.000632617,0.002355689,0.001103866,HSPB1/IFNG/APP,3
BP,GO:0097709,connective tissue replacement,3/160,20/18670,0.000632617,0.002355689,0.001103866,HIF1A/IL1A/PPP3CA,3
BP,GO:1902993,positive regulation of amyloid precursor protein catabolic process,3/160,20/18670,0.000632617,0.002355689,0.001103866,CASP3/IFNG/APP,3
BP,GO:0002673,regulation of acute inflammatory response,4/160,46/18670,0.000640563,0.002374236,0.001112557,PPARG/PTGS2/IL1B/GSTP1,4
BP,GO:0010883,regulation of lipid storage,4/160,46/18670,0.000640563,0.002374236,0.001112557,PPARG/NFKBIA/PPARA/PPARD,4
BP,GO:0033628,regulation of cell adhesion mediated by integrin,4/160,46/18670,0.000640563,0.002374236,0.001112557,DPP4/PLAU/CYP1B1/SERPINE1,4
BP,GO:0035196,production of miRNAs involved in gene silencing by miRNA,4/160,46/18670,0.000640563,0.002374236,0.001112557,ESR1/TP53/EGFR/PPP3CA,4
BP,GO:0071354,cellular response to interleukin-6,4/160,46/18670,0.000640563,0.002374236,0.001112557,RELA/IL6R/STAT1/ICAM1,4
BP,GO:0048708,astrocyte differentiation,5/160,81/18670,0.000658416,0.002435897,0.001141451,EGFR/MAPK1/IL1B/IFNG/APP,5
BP,GO:2001021,negative regulation of response to DNA damage stimulus,5/160,81/18670,0.000658416,0.002435897,0.001141451,BCL2/BCL2L1/CHEK2/CD44/MDM2,5
BP,GO:0043433,negative regulation of DNA-binding transcription factor activity,7/160,170/18670,0.000665954,0.002461507,0.001153452,ESR1/RB1/NFKBIA/HMOX1/CYP1B1/CHUK/CAT,7
BP,GO:0051928,positive regulation of calcium ion transport,6/160,123/18670,0.00067146,0.00247957,0.001161916,BAX/CCL2/CAV1/CXCL11/CXCL10/G6PD,6
BP,GO:0072521,purine-containing compound metabolic process,12/160,464/18670,0.000672093,0.00247962,0.00116194,NOS2/IL4/HIF1A/NOS3/SULT1E1/IFNG/ABCG2/PARP1/PPARA/HK2/APP/ADCY2,12
BP,GO:0010893,positive regulation of steroid biosynthetic process,3/160,21/18670,0.000733428,0.002676311,0.001254108,POR/IL1B/IFNG,3
BP,GO:0015874,norepinephrine transport,3/160,21/18670,0.000733428,0.002676311,0.001254108,ADRA2A/ADRA2C/ADRA2B,3
BP,GO:0017000,antibiotic biosynthetic process,3/160,21/18670,0.000733428,0.002676311,0.001254108,CYP1A2/SOD1/CYP1A1,3
BP,GO:0030728,ovulation,3/160,21/18670,0.000733428,0.002676311,0.001254108,PTGS2/PGR/NOS3,3
BP,GO:0032332,positive regulation of chondrocyte differentiation,3/160,21/18670,0.000733428,0.002676311,0.001254108,RELA/POR/RUNX2,3
BP,GO:0035162,embryonic hemopoiesis,3/160,21/18670,0.000733428,0.002676311,0.001254108,KDR/VEGFA/HIF1A,3
BP,GO:0042135,neurotransmitter catabolic process,3/160,21/18670,0.000733428,0.002676311,0.001254108,ACHE/MAOA/POR,3
BP,GO:0046827,positive regulation of protein export from nucleus,3/160,21/18670,0.000733428,0.002676311,0.001254108,TP53/IL1B/MDM2,3
BP,GO:0051900,regulation of mitochondrial depolarization,3/160,21/18670,0.000733428,0.002676311,0.001254108,BCL2/KDR/PARP1,3
BP,GO:0071498,cellular response to fluid shear stress,3/160,21/18670,0.000733428,0.002676311,0.001254108,PTGS2/CA2/NFE2L2,3
BP,GO:0072111,cell proliferation involved in kidney development,3/160,21/18670,0.000733428,0.002676311,0.001254108,IL6R/STAT1/MYC,3
BP,GO:1902884,positive regulation of response to oxidative stress,3/160,21/18670,0.000733428,0.002676311,0.001254108,MCL1/MMP3/SOD1,3
BP,GO:0055002,striated muscle cell development,7/160,173/18670,0.000738457,0.002692209,0.001261558,BCL2/VEGFA/CCNB1/PPARA/G6PD/PPP3CA/MAP2K4,7
BP,GO:0033044,regulation of chromosome organization,10/160,342/18670,0.000750274,0.002732799,0.001280578,TP53/VEGFA/MAPK1/RB1/MYC/IL1B/CCNB1/PARP1/IGF2/MAPK8,10
BP,GO:0051972,regulation of telomerase activity,4/160,48/18670,0.000753727,0.002740391,0.001284136,PPARG/TP53/MAPK1/MYC,4
BP,GO:0060324,face development,4/160,48/18670,0.000753727,0.002740391,0.001284136,MMP2/MAPK1/RAF1/COL1A1,4
BP,GO:0016579,protein deubiquitination,9/160,283/18670,0.000763901,0.002774862,0.001300289,ESR1/AR/ADRB2/TP53/CCNA2/NFKBIA/HIF1A/MYC/MDM2,9
BP,GO:0045445,myoblast differentiation,5/160,84/18670,0.000777191,0.002815471,0.001319318,MAPK14/RB1/PPARD/CXCL10/IGFBP3,5
BP,GO:0046889,positive regulation of lipid biosynthetic process,5/160,84/18670,0.000777191,0.002815471,0.001319318,PTGS2/AKT1/POR/IL1B/IFNG,5
BP,GO:1905897,regulation of response to endoplasmic reticulum stress,5/160,84/18670,0.000777191,0.002815471,0.001319318,BAX/BCL2L1/HSPA5/CAV1/NFE2L2,5
BP,GO:0003044,regulation of systemic arterial blood pressure mediated by a chemical signal,4/160,49/18670,0.000815297,0.002940212,0.001377771,ADRB2/ADRB1/NOS3/ECE1,4
BP,GO:0043124,negative regulation of I-kappaB kinase/NF-kappaB signaling,4/160,49/18670,0.000815297,0.002940212,0.001377771,ESR1/CASP8/STAT1/GSTP1,4
BP,GO:0097300,programmed necrotic cell death,4/160,49/18670,0.000815297,0.002940212,0.001377771,BAX/TP53/CASP8/CAV1,4
BP,GO:1904707,positive regulation of vascular smooth muscle cell proliferation,4/160,49/18670,0.000815297,0.002940212,0.001377771,JUN/MMP2/MMP9/MDM2,4
BP,GO:1990090,cellular response to nerve growth factor stimulus,4/160,49/18670,0.000815297,0.002940212,0.001377771,AKT1/HSPA5/E2F1/APP,4
BP,GO:0006986,response to unfolded protein,7/160,176/18670,0.000817076,0.002943975,0.001379535,CCND1/BAX/CCL2/CXCL8/HSPA5/HSPB1/NFE2L2,7
BP,GO:0034308,primary alcohol metabolic process,5/160,85/18670,0.000820126,0.002952306,0.001383438,CYP3A4/CYP1A2/CYP1A1/SULT1E1/CYP1B1,5
BP,GO:0032469,endoplasmic reticulum calcium ion homeostasis,3/160,22/18670,0.000843913,0.003024336,0.001417192,BCL2/BAX/APP,3
BP,GO:0032928,regulation of superoxide anion generation,3/160,22/18670,0.000843913,0.003024336,0.001417192,EGFR/SOD1/GSTP1,3
BP,GO:0043496,regulation of protein homodimerization activity,3/160,22/18670,0.000843913,0.003024336,0.001417192,BCL2/BAX/HSPA5,3
BP,GO:0045649,regulation of macrophage differentiation,3/160,22/18670,0.000843913,0.003024336,0.001417192,CASP8/PRKCA/RB1,3
BP,GO:0090312,positive regulation of protein deacetylation,3/160,22/18670,0.000843913,0.003024336,0.001417192,TP53/VEGFA/IFNG,3
BP,GO:1903038,negative regulation of leukocyte cell-cell adhesion,6/160,129/18670,0.000861842,0.003085826,0.001446006,AKT1/CASP3/ERBB2/IL2RA/PPARA/IRF1,6
BP,GO:0070741,response to interleukin-6,4/160,50/18670,0.000880333,0.003149217,0.00147571,RELA/IL6R/STAT1/ICAM1,4
BP,GO:0014068,positive regulation of phosphatidylinositol 3-kinase signaling,5/160,87/18670,0.000911273,0.003251183,0.001523491,KDR/NCF1/PPARD/ERBB3/CAT,5
BP,GO:0043470,regulation of carbohydrate catabolic process,5/160,87/18670,0.000911273,0.003251183,0.001523491,TP53/HIF1A/IFNG/PPARA/APP,5
BP,GO:0051781,positive regulation of cell division,5/160,87/18670,0.000911273,0.003251183,0.001523491,VEGFA/IL1B/IL1A/IGF2/CAT,5
BP,GO:0022408,negative regulation of cell-cell adhesion,7/160,180/18670,0.000932035,0.003319338,0.001555428,AKT1/CASP3/VEGFA/ERBB2/IL2RA/PPARA/IRF1,7
BP,GO:2001257,regulation of cation channel activity,7/160,180/18670,0.000932035,0.003319338,0.001555428,ADRB2/CCL2/OPRM1/MMP9/CAV1/IFNG/APP,7
BP,GO:0030183,B cell differentiation,6/160,131/18670,0.000933759,0.003322521,0.00155692,BCL2/BAX/TP53/IL4/VCAM1/CD40LG,6
BP,GO:0031050,dsRNA processing,4/160,51/18670,0.000948941,0.003367562,0.001578026,ESR1/TP53/EGFR/PPP3CA,4
BP,GO:0045744,negative regulation of G protein-coupled receptor signaling pathway,4/160,51/18670,0.000948941,0.003367562,0.001578026,ADRB2/CXCL8/OPRM1/MET,4
BP,GO:0070918,production of small RNA involved in gene silencing by RNA,4/160,51/18670,0.000948941,0.003367562,0.001578026,ESR1/TP53/EGFR/PPP3CA,4
BP,GO:2000177,regulation of neural precursor cell proliferation,5/160,88/18670,0.000959575,0.003398402,0.001592478,TP53/SLC6A4/VEGFA/EGF/HIF1A,5
BP,GO:0030810,positive regulation of nucleotide biosynthetic process,3/160,23/18670,0.000964423,0.003398402,0.001592478,NOS2/IL4/NOS3,3
BP,GO:0045821,positive regulation of glycolytic process,3/160,23/18670,0.000964423,0.003398402,0.001592478,HIF1A/IFNG/APP,3
BP,GO:0050995,negative regulation of lipid catabolic process,3/160,23/18670,0.000964423,0.003398402,0.001592478,AKT1/ADRA2A/IL1B,3
BP,GO:0051043,regulation of membrane protein ectodomain proteolysis,3/160,23/18670,0.000964423,0.003398402,0.001592478,ADRA2A/IL1B/IFNG,3
BP,GO:0051882,mitochondrial depolarization,3/160,23/18670,0.000964423,0.003398402,0.001592478,BCL2/KDR/PARP1,3
BP,GO:1900373,positive regulation of purine nucleotide biosynthetic process,3/160,23/18670,0.000964423,0.003398402,0.001592478,NOS2/IL4/NOS3,3
BP,GO:1902254,negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator,3/160,23/18670,0.000964423,0.003398402,0.001592478,BCL2/CD44/MDM2,3
BP,GO:0055007,cardiac muscle cell differentiation,6/160,132/18670,0.000971406,0.003416993,0.001601189,RXRA/VEGFA/CCNB1/PPARA/G6PD/MAP2K4,6
BP,GO:0072329,monocarboxylic acid catabolic process,6/160,132/18670,0.000971406,0.003416993,0.001601189,AKT1/PPARA/PPARD/ACOX1/EHHADH/HADHB,6
BP,GO:0007193,adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway,5/160,89/18670,0.001009754,0.003539444,0.001658569,CHRM3/CHRM1/OPRM1/ADRA2A/ADCY2,5
BP,GO:0046427,positive regulation of receptor signaling pathway via JAK-STAT,5/160,89/18670,0.001009754,0.003539444,0.001658569,IL6R/IL4/IL10RA/CYP1B1/IFNG,5
BP,GO:0055013,cardiac muscle cell development,5/160,89/18670,0.001009754,0.003539444,0.001658569,VEGFA/CCNB1/PPARA/G6PD/MAP2K4,5
BP,GO:0097306,cellular response to alcohol,5/160,89/18670,0.001009754,0.003539444,0.001658569,PPARG/AKT1/CDK4/ADCY2/UGT1A1,5
BP,GO:1990089,response to nerve growth factor,4/160,52/18670,0.001021226,0.003576524,0.001675944,AKT1/HSPA5/E2F1/APP,4
BP,GO:0072330,monocarboxylic acid biosynthetic process,8/160,237/18670,0.001022355,0.00357735,0.001676331,PTGS1/PTGS2/LTA4H/CYP3A4/CYP1A2/CYP1A1/IL1B/ALOX5,8
BP,GO:0016236,macroautophagy,9/160,295/18670,0.001023278,0.003577453,0.00167638,ADRB2/AKT1/KDR/CASP3/TP53/IL4/HIF1A/HMOX1/MAPK8,9
BP,GO:0038061,NIK/NF-kappaB signaling,7/160,183/18670,0.001026336,0.00358501,0.001679921,RELA/AKT1/EGFR/NFKBIA/IL1B/CHUK/APP,7
BP,GO:0044409,entry into host,6/160,134/18670,0.001050195,0.003662535,0.001716249,DPP4/CXCL8/EGFR/CAV1/ICAM1/MET,6
BP,GO:0051607,defense response to virus,8/160,238/18670,0.00105036,0.003662535,0.001716249,RELA/BCL2/STAT1/IL1B/IL2RA/IFNG/CXCL10/IRF1,8
BP,GO:0015844,monoamine transport,5/160,90/18670,0.001061856,0.003692972,0.001730511,SLC6A3/SLC6A4/ADRA2A/ADRA2C/ADRA2B,5
BP,GO:0045185,maintenance of protein location,5/160,90/18670,0.001061856,0.003692972,0.001730511,AKT1/NFKBIA/HSPA5/CAV1/HK2,5
BP,GO:0071674,mononuclear cell migration,5/160,90/18670,0.001061856,0.003692972,0.001730511,MAPK14/IL6R/CCL2/SERPINE1/CXCL10,5
BP,GO:0031348,negative regulation of defense response,8/160,239/18670,0.001078975,0.00374925,0.001756883,PPARG/IL4/RB1/SOD1/IL2RA/GSTP1/PPARA/PPARD,8
BP,GO:0002092,positive regulation of receptor internalization,3/160,24/18670,0.001095299,0.003789875,0.00177592,VEGFA/EGF/SELE,3
BP,GO:0009110,vitamin biosynthetic process,3/160,24/18670,0.001095299,0.003789875,0.00177592,CYP3A4/IL1B/IFNG,3
BP,GO:0042104,positive regulation of activated T cell proliferation,3/160,24/18670,0.001095299,0.003789875,0.00177592,IL6R/IL2RA/IGF2,3
BP,GO:0000186,activation of MAPKK activity,4/160,53/18670,0.001097293,0.003789875,0.00177592,EGFR/MAPK1/EGF/RAF1,4
BP,GO:0031638,zymogen activation,4/160,53/18670,0.001097293,0.003789875,0.00177592,CASP8/PLAU/PLAT/SERPINE1,4
BP,GO:0038066,p38MAPK cascade,4/160,53/18670,0.001097293,0.003789875,0.00177592,MAPK14/VEGFA/IL1B/NCF1,4
BP,GO:0045661,regulation of myoblast differentiation,4/160,53/18670,0.001097293,0.003789875,0.00177592,MAPK14/PPARD/CXCL10/IGFBP3,4
BP,GO:0050663,cytokine secretion,8/160,240/18670,0.00110821,0.003824281,0.001792043,NOS2/MAPK14/FN1/IL1B/IFNG/IL1A/CHUK/CASP1,8
BP,GO:0070646,protein modification by small protein removal,9/160,299/18670,0.001124121,0.003875847,0.001816206,ESR1/AR/ADRB2/TP53/CCNA2/NFKBIA/HIF1A/MYC/MDM2,9
BP,GO:0055001,muscle cell development,7/160,186/18670,0.001127988,0.003885832,0.001820885,BCL2/VEGFA/CCNB1/PPARA/G6PD/PPP3CA/MAP2K4,7
BP,GO:0045833,negative regulation of lipid metabolic process,5/160,92/18670,0.001172012,0.004030553,0.001888701,AKT1/ADRA2A/SOD1/IL1B/UGT1A1,5
BP,GO:1904894,positive regulation of receptor signaling pathway via STAT,5/160,92/18670,0.001172012,0.004030553,0.001888701,IL6R/IL4/IL10RA/CYP1B1/IFNG,5
BP,GO:0006636,unsaturated fatty acid biosynthetic process,4/160,54/18670,0.00117725,0.004038157,0.001892264,PTGS1/PTGS2/IL1B/ALOX5,4
BP,GO:0010524,positive regulation of calcium ion transport into cytosol,4/160,54/18670,0.00117725,0.004038157,0.001892264,BAX/CAV1/CXCL11/CXCL10,4
BP,GO:0043392,negative regulation of DNA binding,4/160,54/18670,0.00117725,0.004038157,0.001892264,JUN/NFKBIA/HMOX1/E2F1,4
BP,GO:0009308,amine metabolic process,6/160,138/18670,0.001222425,0.004189526,0.001963195,SLC6A3/MAOA/ODC1/CYP1A1/VCAM1/NQO1,6
BP,GO:1903351,cellular response to dopamine,5/160,93/18670,0.001230157,0.004199485,0.001967861,CHRM3/CHRM1/OPRM1/HTR3A/MAPK1,5
BP,GO:0002053,positive regulation of mesenchymal cell proliferation,3/160,25/18670,0.00123687,0.004199485,0.001967861,VEGFA/STAT1/MYC,3
BP,GO:0009299,mRNA transcription,3/160,25/18670,0.00123687,0.004199485,0.001967861,TP53/HIF1A/PPARD,3
BP,GO:0031639,plasminogen activation,3/160,25/18670,0.00123687,0.004199485,0.001967861,PLAU/PLAT/SERPINE1,3
BP,GO:0045672,positive regulation of osteoclast differentiation,3/160,25/18670,0.00123687,0.004199485,0.001967861,CA2/FOS/IFNG,3
BP,GO:0051953,negative regulation of amine transport,3/160,25/18670,0.00123687,0.004199485,0.001967861,ADRA2A/ADRA2C/ADRA2B,3
BP,GO:0060330,regulation of response to interferon-gamma,3/160,25/18670,0.00123687,0.004199485,0.001967861,PPARG/STAT1/IFNG,3
BP,GO:0060334,regulation of interferon-gamma-mediated signaling pathway,3/160,25/18670,0.00123687,0.004199485,0.001967861,PPARG/STAT1/IFNG,3
BP,GO:0060444,branching involved in mammary gland duct morphogenesis,3/160,25/18670,0.00123687,0.004199485,0.001967861,ESR1/AR/PGR,3
BP,GO:0060571,morphogenesis of an epithelial fold,3/160,25/18670,0.00123687,0.004199485,0.001967861,AR/EGFR/HIF1A,3
BP,GO:2000679,positive regulation of transcription regulatory region DNA binding,3/160,25/18670,0.00123687,0.004199485,0.001967861,RB1/IFNG/PARP1,3
BP,GO:0042306,regulation of protein import into nucleus,4/160,55/18670,0.001261199,0.004271705,0.002001703,PTGS2/MAPK14/MAPK1/IFNG,4
BP,GO:0061098,positive regulation of protein tyrosine kinase activity,4/160,55/18670,0.001261199,0.004271705,0.002001703,ADRA2A/EGF/NCF1/ERBB3,4
BP,GO:0046034,ATP metabolic process,9/160,304/18670,0.001261343,0.004271705,0.002001703,TP53/IL4/HIF1A/CCNB1/IFNG/PARP1/PPARA/HK2/APP,9
BP,GO:0045580,regulation of T cell differentiation,6/160,139/18670,0.001268676,0.004285664,0.002008245,IL4/SOD1/ERBB2/IL2RA/IFNG/IRF1,6
BP,GO:0050715,positive regulation of cytokine secretion,6/160,139/18670,0.001268676,0.004285664,0.002008245,MAPK14/IL1B/IFNG/IL1A/CHUK/CASP1,6
BP,GO:0060968,regulation of gene silencing,6/160,139/18670,0.001268676,0.004285664,0.002008245,ESR1/PPARG/CDK2/TP53/EGFR/PPP3CA,6
BP,GO:0006163,purine nucleotide metabolic process,11/160,432/18670,0.001272928,0.004296401,0.002013276,NOS2/IL4/HIF1A/NOS3/SULT1E1/IFNG/PARP1/PPARA/HK2/APP/ADCY2,11
BP,GO:0045088,regulation of innate immune response,9/160,305/18670,0.001290346,0.004348068,0.002037487,PPARG/RELA/RAF1/STAT1/IFNG/CHUK/IRF1/XIAP/IKBKB,9
BP,GO:1903350,response to dopamine,5/160,94/18670,0.001290409,0.004348068,0.002037487,CHRM3/CHRM1/OPRM1/HTR3A/MAPK1,5
BP,GO:0034620,cellular response to unfolded protein,6/160,140/18670,0.001316255,0.004431429,0.002076549,CCND1/BAX/CCL2/CXCL8/HSPA5/NFE2L2,6
BP,GO:0000086,G2/M transition of mitotic cell cycle,8/160,247/18670,0.001331049,0.004477471,0.002098125,CDK2/CCND1/CDKN1A/CCNA2/CCNB1/CHEK2/CDK4/APP,8
BP,GO:0031295,T cell costimulation,4/160,56/18670,0.001349249,0.004531075,0.002123243,DPP4/AKT1/CAV1/CD40LG,4
BP,GO:0060688,regulation of morphogenesis of a branching structure,4/160,56/18670,0.001349249,0.004531075,0.002123243,ESR1/AR/RXRA/VEGFA,4
BP,GO:0055006,cardiac cell development,5/160,95/18670,0.001352813,0.004531639,0.002123508,VEGFA/CCNB1/PPARA/G6PD/MAP2K4,5
BP,GO:1903076,regulation of protein localization to plasma membrane,5/160,95/18670,0.001352813,0.004531639,0.002123508,AR/AKT1/EGFR/BCL2L1/IFNG,5
BP,GO:2000060,positive regulation of ubiquitin-dependent protein catabolic process,5/160,95/18670,0.001352813,0.004531639,0.002123508,AKT1/EGF/CAV1/NFE2L2/MDM2,5
BP,GO:0008286,insulin receptor signaling pathway,6/160,141/18670,0.001365186,0.004569263,0.002141138,RELA/AKT1/IL1B/INSRR/IGF2/CDK4,6
BP,GO:0060740,prostate gland epithelium morphogenesis,3/160,26/18670,0.001389457,0.004638862,0.002173752,ESR1/AR/RXRA,3
BP,GO:1903203,regulation of oxidative stress-induced neuron death,3/160,26/18670,0.001389457,0.004638862,0.002173752,MCL1/HIF1A/PARP1,3
BP,GO:1903579,negative regulation of ATP metabolic process,3/160,26/18670,0.001389457,0.004638862,0.002173752,TP53/PARP1/PPARA,3
BP,GO:0071560,cellular response to transforming growth factor beta stimulus,8/160,249/18670,0.001400865,0.004673053,0.002189774,JUN/TP53/FOS/HSPA5/CAV1/COL1A1/PARP1/NR3C1,8
BP,GO:0045333,cellular respiration,7/160,194/18670,0.001438026,0.004792635,0.002245809,NOS2/CYP1A2/IL4/HIF1A/CCNB1/IFNG/CAT,7
BP,GO:0031294,lymphocyte costimulation,4/160,57/18670,0.001441502,0.004792635,0.002245809,DPP4/AKT1/CAV1/CD40LG,4
BP,GO:0048008,platelet-derived growth factor receptor signaling pathway,4/160,57/18670,0.001441502,0.004792635,0.002245809,F7/VEGFA/F3/PLAT,4
BP,GO:0060043,regulation of cardiac muscle cell proliferation,4/160,57/18670,0.001441502,0.004792635,0.002245809,MAPK14/MAPK1/GJA1/CCNB1,4
BP,GO:0042113,B cell activation,9/160,310/18670,0.001443553,0.004795472,0.002247139,BCL2/CDKN1A/BAX/CASP3/TP53/CASP8/IL4/VCAM1/CD40LG,9
BP,GO:0031056,regulation of histone modification,6/160,143/18670,0.001467205,0.004865966,0.002280172,TP53/VEGFA/IL1B/CCNB1/IGF2/MAPK8,6
BP,GO:0044344,cellular response to fibroblast growth factor stimulus,6/160,143/18670,0.001467205,0.004865966,0.002280172,CCL2/CXCL8/MAPK1/COL1A1/RUNX2/CD44,6
BP,GO:0030316,osteoclast differentiation,5/160,97/18670,0.001484266,0.004918475,0.002304777,MAPK14/CA2/IL4/FOS/IFNG,5
BP,GO:0071322,cellular response to carbohydrate stimulus,6/160,144/18670,0.001520344,0.005033859,0.002358846,ADRA2A/RAF1/HIF1A/ICAM1/PPP3CA/MAP2K4,6
BP,GO:0071897,DNA biosynthetic process,7/160,196/18670,0.001525049,0.005045265,0.00236419,PPARG/CDKN1A/TP53/TEP1/MAPK1/MYC/GJA1,7
BP,GO:0017001,antibiotic catabolic process,4/160,58/18670,0.001538064,0.005075739,0.00237847,SULT1E1/MPO/UGT1A1/CAT,4
BP,GO:0030520,intracellular estrogen receptor signaling pathway,4/160,58/18670,0.001538064,0.005075739,0.00237847,ESR1/AR/ESR2/PARP1,4
BP,GO:1904589,regulation of protein import,4/160,58/18670,0.001538064,0.005075739,0.00237847,PTGS2/MAPK14/MAPK1/IFNG,4
BP,GO:0002026,regulation of the force of heart contraction,3/160,27/18670,0.001553367,0.005096965,0.002388417,ADRB1/CAV1/NOS3,3
BP,GO:0036475,neuron death in response to oxidative stress,3/160,27/18670,0.001553367,0.005096965,0.002388417,MCL1/HIF1A/PARP1,3
BP,GO:0071280,cellular response to copper ion,3/160,27/18670,0.001553367,0.005096965,0.002388417,CYP1A2/CYP1A1/APP,3
BP,GO:1905208,negative regulation of cardiocyte differentiation,3/160,27/18670,0.001553367,0.005096965,0.002388417,EGFR/PPARA/G6PD,3
BP,GO:2000144,"positive regulation of DNA-templated transcription, initiation",3/160,27/18670,0.001553367,0.005096965,0.002388417,ESR1/JUN/TP53,3
BP,GO:0002042,cell migration involved in sprouting angiogenesis,5/160,98/18670,0.001553409,0.005096965,0.002388417,PTGS2/AKT1/KDR/VEGFA/HMOX1,5
BP,GO:0050764,regulation of phagocytosis,5/160,98/18670,0.001553409,0.005096965,0.002388417,PPARG/CCL2/SOD1/IL1B/IFNG,5
BP,GO:0006898,receptor-mediated endocytosis,9/160,314/18670,0.001576393,0.005168141,0.00242177,ADRB2/CXCL8/ACHE/IL4/VEGFA/EGF/CAV1/SELE/SERPINE1,9
BP,GO:0046890,regulation of lipid biosynthetic process,7/160,198/18670,0.001616127,0.005294073,0.002480781,PTGS2/AKT1/POR/SOD1/IL1B/IFNG/CDK4,7
BP,GO:0062014,negative regulation of small molecule metabolic process,5/160,99/18670,0.001624893,0.005314091,0.002490162,AKT1/TP53/SOD1/PARP1/PPARA,5
BP,GO:1901570,fatty acid derivative biosynthetic process,5/160,99/18670,0.001624893,0.005314091,0.002490162,PTGS1/PTGS2/LTA4H/IL1B/ALOX5,5
BP,GO:0071559,response to transforming growth factor beta,8/160,255/18670,0.001627945,0.005319726,0.002492802,JUN/TP53/FOS/HSPA5/CAV1/COL1A1/PARP1/NR3C1,8
BP,GO:0033619,membrane protein proteolysis,4/160,59/18670,0.00163904,0.005351613,0.002507744,RELA/ADRA2A/IL1B/IFNG,4
BP,GO:0035966,response to topologically incorrect protein,7/160,199/18670,0.001663227,0.00542174,0.002540605,CCND1/BAX/CCL2/CXCL8/HSPA5/HSPB1/NFE2L2,7
BP,GO:0050866,negative regulation of cell activation,7/160,199/18670,0.001663227,0.00542174,0.002540605,CASP3/ERBB2/HMOX1/NOS3/IL2RA/THBD/IRF1,7
BP,GO:0030900,forebrain development,10/160,381/18670,0.001687146,0.005495235,0.002575045,SCN5A/BAX/CASP3/SLC6A3/EGFR/HIF1A/E2F1/HSD3B2/HSD3B1/APP,10
BP,GO:0007215,glutamate receptor signaling pathway,5/160,100/18670,0.001698765,0.005524092,0.002588567,ADRB2/CCL2/OPRM1/IFNG/APP,5
BP,GO:0060079,excitatory postsynaptic potential,5/160,100/18670,0.001698765,0.005524092,0.002588567,ADRB2/AKT1/OPRM1/APP/PPP3CA,5
BP,GO:0001516,prostaglandin biosynthetic process,3/160,28/18670,0.001728899,0.005590292,0.002619588,PTGS1/PTGS2/IL1B,3
BP,GO:0034698,response to gonadotropin,3/160,28/18670,0.001728899,0.005590292,0.002619588,CCNA2/POR/ICAM1,3
BP,GO:0046457,prostanoid biosynthetic process,3/160,28/18670,0.001728899,0.005590292,0.002619588,PTGS1/PTGS2/IL1B,3
BP,GO:0060512,prostate gland morphogenesis,3/160,28/18670,0.001728899,0.005590292,0.002619588,ESR1/AR/RXRA,3
BP,GO:0095500,acetylcholine receptor signaling pathway,3/160,28/18670,0.001728899,0.005590292,0.002619588,CHRM3/CHRM1/OPRM1,3
BP,GO:1902003,regulation of amyloid-beta formation,3/160,28/18670,0.001728899,0.005590292,0.002619588,CASP3/IFNG/APP,3
BP,GO:1902932,positive regulation of alcohol biosynthetic process,3/160,28/18670,0.001728899,0.005590292,0.002619588,POR/IL1B/IFNG,3
BP,GO:0032507,maintenance of protein location in cell,4/160,60/18670,0.001744534,0.005631749,0.002639014,AKT1/HSPA5/CAV1/HK2,4
BP,GO:0046324,regulation of glucose import,4/160,60/18670,0.001744534,0.005631749,0.002639014,MAPK14/AKT1/NFE2L2/HK2,4
BP,GO:0006839,mitochondrial transport,8/160,258/18670,0.001751931,0.005651073,0.00264807,BCL2/BAX/TP53/CASP8/BCL2L1/E2F1/HK2/MAPK8,8
BP,GO:0048259,regulation of receptor-mediated endocytosis,5/160,101/18670,0.001775073,0.005721109,0.002680888,IL4/VEGFA/EGF/SELE/SERPINE1,5
BP,GO:0031349,positive regulation of defense response,10/160,384/18670,0.001787186,0.005755516,0.002697011,PTGS2/RELA/EGFR/NFKBIA/RAF1/GJA1/IL1B/SERPINE1/CHUK/IKBKB,10
BP,GO:0003007,heart morphogenesis,8/160,259/18670,0.00179488,0.005775648,0.002706445,RXRA/JUN/TP53/VEGFA/HIF1A/GJA1/NOS3/MDM2,8
BP,GO:0010522,regulation of calcium ion transport into cytosol,5/160,102/18670,0.001853864,0.005948845,0.002787605,BCL2/BAX/CAV1/CXCL11/CXCL10,5
BP,GO:0030888,regulation of B cell proliferation,4/160,61/18670,0.001854649,0.005948845,0.002787605,BCL2/CDKN1A/CASP3/IL4,4
BP,GO:0032370,positive regulation of lipid transport,4/160,61/18670,0.001854649,0.005948845,0.002787605,PON1/NFKBIA/IL1B/SPP1,4
BP,GO:0045123,cellular extravasation,4/160,61/18670,0.001854649,0.005948845,0.002787605,CCL2/ICAM1/SELE/VCAM1,4
BP,GO:0071774,response to fibroblast growth factor,6/160,150/18670,0.001870618,0.005995263,0.002809356,CCL2/CXCL8/MAPK1/COL1A1/RUNX2/CD44,6
BP,GO:0007271,"synaptic transmission, cholinergic",3/160,29/18670,0.001916341,0.006122198,0.002868837,CHRM3/ACHE/NQO1,3
BP,GO:0010800,positive regulation of peptidyl-threonine phosphorylation,3/160,29/18670,0.001916341,0.006122198,0.002868837,MAPK1/EGF/APP,3
BP,GO:0031063,regulation of histone deacetylation,3/160,29/18670,0.001916341,0.006122198,0.002868837,TP53/VEGFA/MAPK8,3
BP,GO:0035666,TRIF-dependent toll-like receptor signaling pathway,3/160,29/18670,0.001916341,0.006122198,0.002868837,CASP8/CHUK/IKBKB,3
BP,GO:0002753,cytoplasmic pattern recognition receptor signaling pathway,4/160,62/18670,0.001969488,0.006271967,0.002939018,RELA/CASP8/NFKBIA/XIAP,4
BP,GO:0055025,positive regulation of cardiac muscle tissue development,4/160,62/18670,0.001969488,0.006271967,0.002939018,MAPK14/MAPK1/CCNB1/ERBB3,4
BP,GO:0070059,intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress,4/160,62/18670,0.001969488,0.006271967,0.002939018,BCL2/BAX/TP53/BCL2L1,4
BP,GO:0070265,necrotic cell death,4/160,62/18670,0.001969488,0.006271967,0.002939018,BAX/TP53/CASP8/CAV1,4
BP,GO:0001678,cellular glucose homeostasis,6/160,152/18670,0.001999984,0.006358963,0.002979784,ADRA2A/RAF1/HIF1A/ICAM1/HK2/PPP3CA,6
BP,GO:0030902,hindbrain development,6/160,152/18670,0.001999984,0.006358963,0.002979784,SCN5A/BCL2/TP53/SLC6A4/EGF/HSPA5,6
BP,GO:0019233,sensory perception of pain,5/160,104/18670,0.002019089,0.006414613,0.003005862,PTGS2/CCL2/OPRM1/ADRA2C/MAPK1,5
BP,GO:0140014,mitotic nuclear division,8/160,264/18670,0.002022279,0.006419654,0.003008224,EGF/RB1/IL1B/BIRC5/CCNB1/IL1A/CHEK2/IGF2,8
BP,GO:0032371,regulation of sterol transport,4/160,63/18670,0.002089156,0.006610981,0.003097879,PPARG/PON1/EGF/NFKBIA,4
BP,GO:0042982,amyloid precursor protein metabolic process,4/160,63/18670,0.002089156,0.006610981,0.003097879,CASP3/ACHE/IFNG/APP,4
BP,GO:0046622,positive regulation of organ growth,4/160,63/18670,0.002089156,0.006610981,0.003097879,MAPK14/AKT1/MAPK1/CCNB1,4
BP,GO:2000401,regulation of lymphocyte migration,4/160,63/18670,0.002089156,0.006610981,0.003097879,AKT1/CCL2/CXCL10/APP,4
BP,GO:0008593,regulation of Notch signaling pathway,5/160,105/18670,0.002105619,0.006648538,0.003115478,AKT1/EGFR/EGF/NFKBIA/NOS3,5
BP,GO:0010743,regulation of macrophage derived foam cell differentiation,3/160,30/18670,0.002115973,0.006648538,0.003115478,PPARG/NFKBIA/PPARA,3
BP,GO:0045940,positive regulation of steroid metabolic process,3/160,30/18670,0.002115973,0.006648538,0.003115478,POR/IL1B/IFNG,3
BP,GO:0046320,regulation of fatty acid oxidation,3/160,30/18670,0.002115973,0.006648538,0.003115478,PPARG/AKT1/PPARA,3
BP,GO:0048873,homeostasis of number of cells within a tissue,3/160,30/18670,0.002115973,0.006648538,0.003115478,BCL2/BAX/NOS3,3
BP,GO:0090200,positive regulation of release of cytochrome c from mitochondria,3/160,30/18670,0.002115973,0.006648538,0.003115478,BAX/TP53/MMP9,3
BP,GO:0097421,liver regeneration,3/160,30/18670,0.002115973,0.006648538,0.003115478,CCND1/EGFR/HMOX1,3
BP,GO:1905144,response to acetylcholine,3/160,30/18670,0.002115973,0.006648538,0.003115478,CHRM3/CHRM1/OPRM1,3
BP,GO:1905145,cellular response to acetylcholine,3/160,30/18670,0.002115973,0.006648538,0.003115478,CHRM3/CHRM1/OPRM1,3
BP,GO:1901617,organic hydroxy compound biosynthetic process,8/160,266/18670,0.002119356,0.006653946,0.003118012,SLC6A3/CYP3A4/POR/SOD1/IL1B/IFNG/TYR/G6PD,8
BP,GO:0051216,cartilage development,7/160,209/18670,0.002195352,0.006887141,0.003227286,MAPK14/RELA/POR/HIF1A/COL1A1/RUNX2/CD44,7
BP,GO:1903707,negative regulation of hemopoiesis,6/160,155/18670,0.002206585,0.006916961,0.00324126,IL4/NFKBIA/ERBB2/MYC/NFE2L2/IRF1,6
BP,GO:0045670,regulation of osteoclast differentiation,4/160,64/18670,0.002213753,0.00692858,0.003246704,CA2/IL4/FOS/IFNG,4
BP,GO:1903672,positive regulation of sprouting angiogenesis,4/160,64/18670,0.002213753,0.00692858,0.003246704,PTGS2/KDR/VEGFA/HMOX1,4
BP,GO:0050707,regulation of cytokine secretion,7/160,210/18670,0.002255044,0.007052299,0.003304679,MAPK14/FN1/IL1B/IFNG/IL1A/CHUK/CASP1,7
BP,GO:0010543,regulation of platelet activation,3/160,31/18670,0.002328062,0.007246681,0.003395765,PRKCA/NOS3/THBD,3
BP,GO:0019048,modulation by virus of host process,3/160,31/18670,0.002328062,0.007246681,0.003395765,RXRA/CASP8/BCL2L1,3
BP,GO:0033198,response to ATP,3/160,31/18670,0.002328062,0.007246681,0.003395765,PTGS2/SOD1/IL1B,3
BP,GO:0040018,positive regulation of multicellular organism growth,3/160,31/18670,0.002328062,0.007246681,0.003395765,BCL2/SLC6A3/IGF2,3
BP,GO:0045648,positive regulation of erythrocyte differentiation,3/160,31/18670,0.002328062,0.007246681,0.003395765,MAPK14/HIF1A/STAT1,3
BP,GO:1902230,negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage,3/160,31/18670,0.002328062,0.007246681,0.003395765,BCL2/BCL2L1/CD44,3
BP,GO:0002548,monocyte chemotaxis,4/160,65/18670,0.002343382,0.007283042,0.003412804,IL6R/CCL2/SERPINE1/CXCL10,4
BP,GO:0051187,cofactor catabolic process,4/160,65/18670,0.002343382,0.007283042,0.003412804,HMOX1/MPO/UGT1A1/CAT,4
BP,GO:0032526,response to retinoic acid,5/160,108/18670,0.002381456,0.007389898,0.003462876,PPARG/RXRA/SLC6A4/GJA1/COL1A1,5
BP,GO:0099565,"chemical synaptic transmission, postsynaptic",5/160,108/18670,0.002381456,0.007389898,0.003462876,ADRB2/AKT1/OPRM1/APP/PPP3CA,5
BP,GO:0052126,movement in host environment,6/160,158/18670,0.002428901,0.007531285,0.003529129,DPP4/CXCL8/EGFR/CAV1/ICAM1/MET,6
BP,GO:0046626,regulation of insulin receptor signaling pathway,4/160,66/18670,0.002478144,0.007678026,0.003597892,RELA/IL1B/IGF2/CDK4,4
BP,GO:0001975,response to amphetamine,3/160,32/18670,0.002552868,0.007848795,0.003677913,SOD1/ICAM1/PPP3CA,3
BP,GO:0042573,retinoic acid metabolic process,3/160,32/18670,0.002552868,0.007848795,0.003677913,CYP3A4/CYP1A1/UGT1A1,3
BP,GO:0045589,regulation of regulatory T cell differentiation,3/160,32/18670,0.002552868,0.007848795,0.003677913,IL2RA/IFNG/IRF1,3
BP,GO:0045987,positive regulation of smooth muscle contraction,3/160,32/18670,0.002552868,0.007848795,0.003677913,PTGS2/CHRM3/ADRA2B,3
BP,GO:0046685,response to arsenic-containing substance,3/160,32/18670,0.002552868,0.007848795,0.003677913,CDKN1A/HMOX1/CYP1A1,3
BP,GO:0051968,"positive regulation of synaptic transmission, glutamatergic",3/160,32/18670,0.002552868,0.007848795,0.003677913,PTGS2/CCL2/EGFR,3
BP,GO:0055022,negative regulation of cardiac muscle tissue growth,3/160,32/18670,0.002552868,0.007848795,0.003677913,GJA1/PPARA/G6PD,3
BP,GO:0061117,negative regulation of heart growth,3/160,32/18670,0.002552868,0.007848795,0.003677913,GJA1/PPARA/G6PD,3
BP,GO:0071295,cellular response to vitamin,3/160,32/18670,0.002552868,0.007848795,0.003677913,PPARG/COL1A1/MDM2,3
BP,GO:1900745,positive regulation of p38MAPK cascade,3/160,32/18670,0.002552868,0.007848795,0.003677913,VEGFA/IL1B/NCF1,3
BP,GO:0010810,regulation of cell-substrate adhesion,7/160,215/18670,0.002572552,0.007903245,0.003703428,BCL2/KDR/FN1/PLAU/VEGFA/SERPINE1/COL1A1,7
BP,GO:0007519,skeletal muscle tissue development,6/160,160/18670,0.002586207,0.007939099,0.003720229,MAPK14/BCL2/FOS/RB1/CAV1/PPP3CA,6
BP,GO:0035967,cellular response to topologically incorrect protein,6/160,161/18670,0.002667671,0.008182903,0.003834475,CCND1/BAX/CCL2/CXCL8/HSPA5/NFE2L2,6
BP,GO:0044242,cellular lipid catabolic process,7/160,217/18670,0.00270877,0.008302607,0.003890568,AKT1/CYP1B1/PPARA/PPARD/ACOX1/EHHADH/HADHB,7
BP,GO:0006625,protein targeting to peroxisome,4/160,68/18670,0.002763468,0.008411851,0.003941759,NOS2/ACOX1/EHHADH/CAT,4
BP,GO:0071230,cellular response to amino acid stimulus,4/160,68/18670,0.002763468,0.008411851,0.003941759,MMP2/EGFR/BCL2L1/COL1A1,4
BP,GO:0072662,protein localization to peroxisome,4/160,68/18670,0.002763468,0.008411851,0.003941759,NOS2/ACOX1/EHHADH/CAT,4
BP,GO:0072663,establishment of protein localization to peroxisome,4/160,68/18670,0.002763468,0.008411851,0.003941759,NOS2/ACOX1/EHHADH/CAT,4
BP,GO:0019722,calcium-mediated signaling,7/160,218/18670,0.002778923,0.008411851,0.003941759,KDR/CXCL8/EGFR/SELE/VCAM1/ERBB3/PPP3CA,7
BP,GO:0002065,columnar/cuboidal epithelial cell differentiation,5/160,112/18670,0.002788964,0.008411851,0.003941759,RXRA/CDKN1A/SOD1/HIF1A/SERPINE1,5
BP,GO:0010906,regulation of glucose metabolic process,5/160,112/18670,0.002788964,0.008411851,0.003941759,AKT1/TP53/PPARA/IGFBP3/IGF2,5
BP,GO:0015918,sterol transport,5/160,112/18670,0.002788964,0.008411851,0.003941759,PPARG/PON1/EGF/NFKBIA/CAV1,5
BP,GO:0032411,positive regulation of transporter activity,5/160,112/18670,0.002788964,0.008411851,0.003941759,ADRB2/CCL2/PON1/HTR3A/IFNG,5
BP,GO:0042303,molting cycle,5/160,112/18670,0.002788964,0.008411851,0.003941759,PTGS2/RELA/BCL2/EGFR/HPSE,5
BP,GO:0042633,hair cycle,5/160,112/18670,0.002788964,0.008411851,0.003941759,PTGS2/RELA/BCL2/EGFR/HPSE,5
BP,GO:0002756,MyD88-independent toll-like receptor signaling pathway,3/160,33/18670,0.002790642,0.008411851,0.003941759,CASP8/CHUK/IKBKB,3
BP,GO:0010464,regulation of mesenchymal cell proliferation,3/160,33/18670,0.002790642,0.008411851,0.003941759,VEGFA/STAT1/MYC,3
BP,GO:0010955,negative regulation of protein processing,3/160,33/18670,0.002790642,0.008411851,0.003941759,SERPINE1/MDM2/XIAP,3
BP,GO:0014072,response to isoquinoline alkaloid,3/160,33/18670,0.002790642,0.008411851,0.003941759,RELA/OPRM1/MDM2,3
BP,GO:0016242,negative regulation of macroautophagy,3/160,33/18670,0.002790642,0.008411851,0.003941759,AKT1/TP53/HMOX1,3
BP,GO:0043278,response to morphine,3/160,33/18670,0.002790642,0.008411851,0.003941759,RELA/OPRM1/MDM2,3
BP,GO:0060603,mammary gland duct morphogenesis,3/160,33/18670,0.002790642,0.008411851,0.003941759,ESR1/AR/PGR,3
BP,GO:0061036,positive regulation of cartilage development,3/160,33/18670,0.002790642,0.008411851,0.003941759,RELA/POR/RUNX2,3
BP,GO:1901797,negative regulation of signal transduction by p53 class mediator,3/160,33/18670,0.002790642,0.008411851,0.003941759,BCL2/CD44/MDM2,3
BP,GO:1902692,regulation of neuroblast proliferation,3/160,33/18670,0.002790642,0.008411851,0.003941759,TP53/VEGFA/HIF1A,3
BP,GO:1903318,negative regulation of protein maturation,3/160,33/18670,0.002790642,0.008411851,0.003941759,SERPINE1/MDM2/XIAP,3
BP,GO:0034329,cell junction assembly,10/160,409/18670,0.002821858,0.008499547,0.003982853,BCL2/KDR/FN1/ACHE/PRKCA/VEGFA/CAV1/GJA1/APP/IKBKB,10
BP,GO:0051651,maintenance of location in cell,7/160,219/18670,0.002850464,0.008579255,0.004020204,AKT1/BAX/HSPA5/CAV1/CXCL11/CXCL10/HK2,7
BP,GO:0006096,glycolytic process,5/160,113/18670,0.002898258,0.008703471,0.004078411,HIF1A/IFNG/PPARA/HK2/APP,5
BP,GO:0035821,modulation of process of other organism,5/160,113/18670,0.002898258,0.008703471,0.004078411,RXRA/JUN/CASP8/BCL2L1/SLPI,5
BP,GO:0060964,regulation of gene silencing by miRNA,5/160,113/18670,0.002898258,0.008703471,0.004078411,ESR1/PPARG/TP53/EGFR/PPP3CA,5
BP,GO:0008088,axo-dendritic transport,4/160,69/18670,0.002914229,0.008744871,0.004097811,SOD1/HIF1A/HSPB1/APP,4
BP,GO:0048762,mesenchymal cell differentiation,7/160,220/18670,0.002923411,0.008759997,0.004104899,BCL2/FN1/MAPK1/HIF1A/STAT1/IL1B/COL1A1,7
BP,GO:0007088,regulation of mitotic nuclear division,6/160,164/18670,0.002923646,0.008759997,0.004104899,EGF/RB1/IL1B/CCNB1/IL1A/IGF2,6
BP,GO:0006757,ATP generation from ADP,5/160,114/18670,0.003010617,0.009013836,0.004223847,HIF1A/IFNG/PPARA/HK2/APP,5
BP,GO:0034205,amyloid-beta formation,3/160,34/18670,0.003041623,0.009086282,0.004257795,CASP3/IFNG/APP,3
BP,GO:0043516,"regulation of DNA damage response, signal transduction by p53 class mediator",3/160,34/18670,0.003041623,0.009086282,0.004257795,TP53/CD44/MDM2,3
BP,GO:0045066,regulatory T cell differentiation,3/160,34/18670,0.003041623,0.009086282,0.004257795,IL2RA/IFNG/IRF1,3
BP,GO:0033077,T cell differentiation in thymus,4/160,70/18670,0.003070521,0.009152118,0.004288645,BCL2/TP53/SOD1/ERBB2,4
BP,GO:0043574,peroxisomal transport,4/160,70/18670,0.003070521,0.009152118,0.004288645,NOS2/ACOX1/EHHADH/CAT,4
BP,GO:0070988,demethylation,4/160,70/18670,0.003070521,0.009152118,0.004288645,CYP3A4/CYP1A2/POR/CYP1A1,4
BP,GO:1904375,regulation of protein localization to cell periphery,5/160,115/18670,0.003126089,0.009233761,0.004326903,AR/AKT1/EGFR/BCL2L1/IFNG,5
BP,GO:0010749,regulation of nitric oxide mediated signal transduction,2/160,10/18670,0.003139432,0.009233761,0.004326903,EGFR/VEGFA,2
BP,GO:0021936,regulation of cerebellar granule cell precursor proliferation,2/160,10/18670,0.003139432,0.009233761,0.004326903,SLC6A4/EGF,2
BP,GO:0031284,positive regulation of guanylate cyclase activity,2/160,10/18670,0.003139432,0.009233761,0.004326903,NOS2/NOS3,2
BP,GO:0034350,regulation of glial cell apoptotic process,2/160,10/18670,0.003139432,0.009233761,0.004326903,CCL2/PRKCA,2
BP,GO:0045348,positive regulation of MHC class II biosynthetic process,2/160,10/18670,0.003139432,0.009233761,0.004326903,IL4/IFNG,2
BP,GO:0051901,positive regulation of mitochondrial depolarization,2/160,10/18670,0.003139432,0.009233761,0.004326903,KDR/PARP1,2
BP,GO:0051918,negative regulation of fibrinolysis,2/160,10/18670,0.003139432,0.009233761,0.004326903,THBD/SERPINE1,2
BP,GO:0060068,vagina development,2/160,10/18670,0.003139432,0.009233761,0.004326903,ESR1/BAX,2
BP,GO:0060346,bone trabecula formation,2/160,10/18670,0.003139432,0.009233761,0.004326903,MMP2/COL1A1,2
BP,GO:0060371,regulation of atrial cardiac muscle cell membrane depolarization,2/160,10/18670,0.003139432,0.009233761,0.004326903,SCN5A/GJA1,2
BP,GO:0070391,response to lipoteichoic acid,2/160,10/18670,0.003139432,0.009233761,0.004326903,MAPK14/RELA,2
BP,GO:0070472,regulation of uterine smooth muscle contraction,2/160,10/18670,0.003139432,0.009233761,0.004326903,ADRA2C/ADRA2B,2
BP,GO:0071223,cellular response to lipoteichoic acid,2/160,10/18670,0.003139432,0.009233761,0.004326903,MAPK14/RELA,2
BP,GO:0071281,cellular response to iron ion,2/160,10/18670,0.003139432,0.009233761,0.004326903,HMOX1/CCNB1,2
BP,GO:0072203,cell proliferation involved in metanephros development,2/160,10/18670,0.003139432,0.009233761,0.004326903,STAT1/MYC,2
BP,GO:0090336,positive regulation of brown fat cell differentiation,2/160,10/18670,0.003139432,0.009233761,0.004326903,PTGS2/MAPK14,2
BP,GO:1903800,positive regulation of production of miRNAs involved in gene silencing by miRNA,2/160,10/18670,0.003139432,0.009233761,0.004326903,TP53/EGFR,2
BP,GO:0007178,transmembrane receptor protein serine/threonine kinase signaling pathway,9/160,349/18670,0.003208262,0.009429276,0.004418521,MAPK14/JUN/TP53/FOS/HSPA5/CAV1/PARP1/RUNX2/XIAP,9
BP,GO:0042440,pigment metabolic process,4/160,71/18670,0.003232441,0.009486409,0.004445292,BCL2/HMOX1/TYR/UGT1A1,4
BP,GO:1904427,positive regulation of calcium ion transmembrane transport,4/160,71/18670,0.003232441,0.009486409,0.004445292,BAX/CXCL11/CXCL10/G6PD,4
BP,GO:0060251,regulation of glial cell proliferation,3/160,35/18670,0.003306044,0.009688211,0.004539856,CHRM1/IL1B/E2F1,3
BP,GO:1902991,regulation of amyloid precursor protein catabolic process,3/160,35/18670,0.003306044,0.009688211,0.004539856,CASP3/IFNG/APP,3
BP,GO:0051153,regulation of striated muscle cell differentiation,5/160,117/18670,0.003366567,0.009836764,0.004609468,MAPK14/BCL2/PPARA/CXCL10/G6PD,5
BP,GO:0060147,regulation of posttranscriptional gene silencing,5/160,117/18670,0.003366567,0.009836764,0.004609468,ESR1/PPARG/TP53/EGFR/PPP3CA,5
BP,GO:0060966,regulation of gene silencing by RNA,5/160,117/18670,0.003366567,0.009836764,0.004609468,ESR1/PPARG/TP53/EGFR/PPP3CA,5
BP,GO:1901222,regulation of NIK/NF-kappaB signaling,5/160,117/18670,0.003366567,0.009836764,0.004609468,RELA/EGFR/NFKBIA/IL1B/APP,5
BP,GO:0021543,pallium development,6/160,169/18670,0.00339056,0.009878029,0.004628804,BAX/CASP3/EGFR/HIF1A/HSD3B2/HSD3B1,6
BP,GO:0030307,positive regulation of cell growth,6/160,169/18670,0.00339056,0.009878029,0.004628804,AKT1/BCL2/FN1/EGFR/VEGFA/ERBB2,6
BP,GO:0045619,regulation of lymphocyte differentiation,6/160,169/18670,0.00339056,0.009878029,0.004628804,IL4/SOD1/ERBB2/IL2RA/IFNG/IRF1,6
BP,GO:0060538,skeletal muscle organ development,6/160,169/18670,0.00339056,0.009878029,0.004628804,MAPK14/BCL2/FOS/RB1/CAV1/PPP3CA,6
BP,GO:0002532,production of molecular mediator involved in inflammatory response,4/160,72/18670,0.003400087,0.009891387,0.004635064,NOS2/MAPK14/SERPINE1/ALOX5,4
BP,GO:0050805,negative regulation of synaptic transmission,4/160,72/18670,0.003400087,0.009891387,0.004635064,PTGS2/ACHE/SLC6A4/IL1B,4
BP,GO:0061844,antimicrobial humoral immune response mediated by antimicrobial peptide,4/160,73/18670,0.003573555,0.010388482,0.004868,CXCL8/CXCL11/CXCL2/CXCL10,4
BP,GO:0030947,regulation of vascular endothelial growth factor receptor signaling pathway,3/160,36/18670,0.003584129,0.01039657,0.00487179,VEGFA/HIF1A/IL1B,3
BP,GO:0034390,smooth muscle cell apoptotic process,3/160,36/18670,0.003584129,0.01039657,0.00487179,PPARG/IFNG/MAP2K4,3
BP,GO:0034391,regulation of smooth muscle cell apoptotic process,3/160,36/18670,0.003584129,0.01039657,0.00487179,PPARG/IFNG/MAP2K4,3
BP,GO:0046394,carboxylic acid biosynthetic process,9/160,355/18670,0.003588508,0.010401735,0.004874211,PTGS1/PTGS2/LTA4H/CYP3A4/CYP1A2/EGF/CYP1A1/IL1B/ALOX5,9
BP,GO:0003205,cardiac chamber development,6/160,171/18670,0.003592087,0.010404577,0.004875542,SCN5A/RXRA/TP53/HIF1A/NOS3/MDM2,6
BP,GO:0001952,regulation of cell-matrix adhesion,5/160,119/18670,0.003620081,0.01047808,0.004909986,BCL2/KDR/PLAU/VEGFA/SERPINE1,5
BP,GO:0019693,ribose phosphate metabolic process,10/160,424/18670,0.003643318,0.010537717,0.004937931,IL4/HIF1A/SULT1E1/IFNG/PARP1/PPARA/HK2/APP/ADCY2/G6PD,10
BP,GO:0006959,humoral immune response,9/160,356/18670,0.003655189,0.010556798,0.004946872,BCL2/CCL2/CXCL8/IL1B/IFNG/CXCL11/CXCL2/CXCL10/SLPI,9
BP,GO:0016053,organic acid biosynthetic process,9/160,356/18670,0.003655189,0.010556798,0.004946872,PTGS1/PTGS2/LTA4H/CYP3A4/CYP1A2/EGF/CYP1A1/IL1B/ALOX5,9
BP,GO:0030324,lung development,6/160,172/18670,0.003696128,0.010659655,0.004995071,PGR/CYP1A2/EGFR/VEGFA/MAPK1/NOS3,6
BP,GO:0032874,positive regulation of stress-activated MAPK cascade,6/160,172/18670,0.003696128,0.010659655,0.004995071,VEGFA/IL1B/NCF1/CD40LG/APP/MAP2K4,6
BP,GO:0090287,regulation of cellular response to growth factor stimulus,8/160,292/18670,0.003747144,0.010792396,0.005057273,TP53/VEGFA/HIF1A/HSPA5/CAV1/IL1B/RUNX2/XIAP,8
BP,GO:1903052,positive regulation of proteolysis involved in cellular protein catabolic process,5/160,120/18670,0.003751848,0.010792396,0.005057273,AKT1/EGF/CAV1/NFE2L2/MDM2,5
BP,GO:0014015,positive regulation of gliogenesis,4/160,74/18670,0.003752939,0.010792396,0.005057273,PPARG/RELA/IL1B/E2F1,4
BP,GO:1900076,regulation of cellular response to insulin stimulus,4/160,74/18670,0.003752939,0.010792396,0.005057273,RELA/IL1B/IGF2/CDK4,4
BP,GO:0070304,positive regulation of stress-activated protein kinase signaling cascade,6/160,173/18670,0.003802392,0.010824697,0.005072409,VEGFA/IL1B/NCF1/CD40LG/APP/MAP2K4,6
BP,GO:0006702,androgen biosynthetic process,2/160,11/18670,0.00381555,0.010824697,0.005072409,HSD3B2/HSD3B1,2
BP,GO:0016264,gap junction assembly,2/160,11/18670,0.00381555,0.010824697,0.005072409,CAV1/GJA1,2
BP,GO:0019371,cyclooxygenase pathway,2/160,11/18670,0.00381555,0.010824697,0.005072409,PTGS1/PTGS2,2
BP,GO:0031652,positive regulation of heat generation,2/160,11/18670,0.00381555,0.010824697,0.005072409,PTGS2/IL1B,2
BP,GO:0033148,positive regulation of intracellular estrogen receptor signaling pathway,2/160,11/18670,0.00381555,0.010824697,0.005072409,AR/PARP1,2
BP,GO:0033327,Leydig cell differentiation,2/160,11/18670,0.00381555,0.010824697,0.005072409,AR/CCND1,2
BP,GO:0033629,negative regulation of cell adhesion mediated by integrin,2/160,11/18670,0.00381555,0.010824697,0.005072409,CYP1B1/SERPINE1,2
BP,GO:0040015,negative regulation of multicellular organism growth,2/160,11/18670,0.00381555,0.010824697,0.005072409,ADRB2/ADRB1,2
BP,GO:0045899,positive regulation of RNA polymerase II transcription preinitiation complex assembly,2/160,11/18670,0.00381555,0.010824697,0.005072409,ESR1/TP53,2
BP,GO:0051974,negative regulation of telomerase activity,2/160,11/18670,0.00381555,0.010824697,0.005072409,PPARG/TP53,2
BP,GO:0060525,prostate glandular acinus development,2/160,11/18670,0.00381555,0.010824697,0.005072409,ESR1/RXRA,2
BP,GO:0060736,prostate gland growth,2/160,11/18670,0.00381555,0.010824697,0.005072409,ESR1/AR,2
BP,GO:0070471,uterine smooth muscle contraction,2/160,11/18670,0.00381555,0.010824697,0.005072409,ADRA2C/ADRA2B,2
BP,GO:0070673,response to interleukin-18,2/160,11/18670,0.00381555,0.010824697,0.005072409,AKT1/ALOX5,2
BP,GO:0072584,caveolin-mediated endocytosis,2/160,11/18670,0.00381555,0.010824697,0.005072409,MAPK1/CAV1,2
BP,GO:0072683,T cell extravasation,2/160,11/18670,0.00381555,0.010824697,0.005072409,CCL2/ICAM1,2
BP,GO:1990440,positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress,2/160,11/18670,0.00381555,0.010824697,0.005072409,TP53/HSPA5,2
BP,GO:2001269,positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway,2/160,11/18670,0.00381555,0.010824697,0.005072409,BAX/CASP8,2
BP,GO:0001662,behavioral fear response,3/160,37/18670,0.00387609,0.010965362,0.005138324,DPP4/BCL2/GJA1,3
BP,GO:0032885,regulation of polysaccharide biosynthetic process,3/160,37/18670,0.00387609,0.010965362,0.005138324,AKT1/EGF/IGF2,3
BP,GO:0032941,secretion by tissue,3/160,37/18670,0.00387609,0.010965362,0.005138324,CHRM3/CHRM1/GJA1,3
BP,GO:2000142,"regulation of DNA-templated transcription, initiation",3/160,37/18670,0.00387609,0.010965362,0.005138324,ESR1/JUN/TP53,3
BP,GO:2001252,positive regulation of chromosome organization,6/160,174/18670,0.003910907,0.011056045,0.005180818,TP53/VEGFA/MAPK1/RB1/IL1B/CCNB1,6
BP,GO:0046165,alcohol biosynthetic process,6/160,175/18670,0.004021702,0.011356348,0.005321538,CYP3A4/POR/SOD1/IL1B/IFNG/G6PD,6
BP,GO:0019730,antimicrobial humoral response,5/160,122/18670,0.004025645,0.011356348,0.005321538,CXCL8/CXCL11/CXCL2/CXCL10/SLPI,5
BP,GO:0046031,ADP metabolic process,5/160,122/18670,0.004025645,0.011356348,0.005321538,HIF1A/IFNG/PPARA/HK2/APP,5
BP,GO:0048588,developmental cell growth,7/160,234/18670,0.004102447,0.011564855,0.005419244,FN1/VEGFA/PPARA/SPP1/APP/G6PD/MAP2K4,7
BP,GO:0072088,nephron epithelium morphogenesis,4/160,76/18670,0.004129835,0.011633871,0.005451585,BCL2/VEGFA/STAT1/MYC,4
BP,GO:0030323,respiratory tube development,6/160,176/18670,0.004134807,0.011639685,0.005454309,PGR/CYP1A2/EGFR/VEGFA/MAPK1/NOS3,6
BP,GO:0002209,behavioral defense response,3/160,38/18670,0.004182134,0.011682541,0.005474391,DPP4/BCL2/GJA1,3
BP,GO:0003298,physiological muscle hypertrophy,3/160,38/18670,0.004182134,0.011682541,0.005474391,PPARA/G6PD/MAP2K4,3
BP,GO:0003301,physiological cardiac muscle hypertrophy,3/160,38/18670,0.004182134,0.011682541,0.005474391,PPARA/G6PD/MAP2K4,3
BP,GO:0010907,positive regulation of glucose metabolic process,3/160,38/18670,0.004182134,0.011682541,0.005474391,AKT1/PPARA/IGF2,3
BP,GO:0046326,positive regulation of glucose import,3/160,38/18670,0.004182134,0.011682541,0.005474391,MAPK14/AKT1/NFE2L2,3
BP,GO:0046825,regulation of protein export from nucleus,3/160,38/18670,0.004182134,0.011682541,0.005474391,TP53/IL1B/MDM2,3
BP,GO:0048009,insulin-like growth factor receptor signaling pathway,3/160,38/18670,0.004182134,0.011682541,0.005474391,AR/AKT1/IGFBP3,3
BP,GO:0060045,positive regulation of cardiac muscle cell proliferation,3/160,38/18670,0.004182134,0.011682541,0.005474391,MAPK14/MAPK1/CCNB1,3
BP,GO:0061049,cell growth involved in cardiac muscle cell development,3/160,38/18670,0.004182134,0.011682541,0.005474391,PPARA/G6PD/MAP2K4,3
BP,GO:1905898,positive regulation of response to endoplasmic reticulum stress,3/160,38/18670,0.004182134,0.011682541,0.005474391,BAX/CAV1/NFE2L2,3
BP,GO:2000279,negative regulation of DNA biosynthetic process,3/160,38/18670,0.004182134,0.011682541,0.005474391,PPARG/TP53/GJA1,3
BP,GO:0014013,regulation of gliogenesis,5/160,124/18670,0.004313448,0.01202994,0.005637181,PPARG/RELA/CHRM1/IL1B/E2F1,5
BP,GO:0019218,regulation of steroid metabolic process,5/160,124/18670,0.004313448,0.01202994,0.005637181,POR/SOD1/IL1B/IFNG/UGT1A1,5
BP,GO:0006110,regulation of glycolytic process,4/160,77/18670,0.004327533,0.01202994,0.005637181,HIF1A/IFNG/PPARA/APP,4
BP,GO:0032481,positive regulation of type I interferon production,4/160,77/18670,0.004327533,0.01202994,0.005637181,RELA/STAT1/CHUK/IRF1,4
BP,GO:0051937,catecholamine transport,4/160,77/18670,0.004327533,0.01202994,0.005637181,SLC6A3/ADRA2A/ADRA2C/ADRA2B,4
BP,GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia,4/160,77/18670,0.004327533,0.01202994,0.005637181,TP53/VEGFA/HIF1A/NFE2L2,4
BP,GO:1901224,positive regulation of NIK/NF-kappaB signaling,4/160,77/18670,0.004327533,0.01202994,0.005637181,RELA/EGFR/IL1B/APP,4
BP,GO:0007210,serotonin receptor signaling pathway,3/160,39/18670,0.004502458,0.012398357,0.00580982,CHRM3/CHRM1/HTR3A,3
BP,GO:0010874,regulation of cholesterol efflux,3/160,39/18670,0.004502458,0.012398357,0.00580982,PON1/EGF/NFKBIA,3
BP,GO:0033146,regulation of intracellular estrogen receptor signaling pathway,3/160,39/18670,0.004502458,0.012398357,0.00580982,ESR1/AR/PARP1,3
BP,GO:0033574,response to testosterone,3/160,39/18670,0.004502458,0.012398357,0.00580982,AR/SPP1/CDK4,3
BP,GO:0060306,regulation of membrane repolarization,3/160,39/18670,0.004502458,0.012398357,0.00580982,SCN5A/CAV1/GJA1,3
BP,GO:0072595,maintenance of protein localization in organelle,3/160,39/18670,0.004502458,0.012398357,0.00580982,AKT1/HSPA5/HK2,3
BP,GO:1902229,regulation of intrinsic apoptotic signaling pathway in response to DNA damage,3/160,39/18670,0.004502458,0.012398357,0.00580982,BCL2/BCL2L1/CD44,3
BP,GO:0031016,pancreas development,4/160,78/18670,0.004531519,0.012398357,0.00580982,AKT1/IL6R/IGF2/MET,4
BP,GO:0070664,negative regulation of leukocyte proliferation,4/160,78/18670,0.004531519,0.012398357,0.00580982,CASP3/ERBB2/IL2RA/GSTP1,4
BP,GO:0072028,nephron morphogenesis,4/160,78/18670,0.004531519,0.012398357,0.00580982,BCL2/VEGFA/STAT1/MYC,4
BP,GO:0002024,diet induced thermogenesis,2/160,12/18670,0.004552982,0.012398357,0.00580982,ADRB2/ADRB1,2
BP,GO:0002674,negative regulation of acute inflammatory response,2/160,12/18670,0.004552982,0.012398357,0.00580982,PPARG/GSTP1,2
BP,GO:0006527,arginine catabolic process,2/160,12/18670,0.004552982,0.012398357,0.00580982,NOS2/NOS3,2
BP,GO:0006983,ER overload response,2/160,12/18670,0.004552982,0.012398357,0.00580982,TP53/HSPA5,2
BP,GO:0007077,mitotic nuclear envelope disassembly,2/160,12/18670,0.004552982,0.012398357,0.00580982,PRKCA/CCNB1,2
BP,GO:0010889,regulation of sequestering of triglyceride,2/160,12/18670,0.004552982,0.012398357,0.00580982,PPARG/PPARA,2
BP,GO:0019336,phenol-containing compound catabolic process,2/160,12/18670,0.004552982,0.012398357,0.00580982,SLC6A3/MAOA,2
BP,GO:0031282,regulation of guanylate cyclase activity,2/160,12/18670,0.004552982,0.012398357,0.00580982,NOS2/NOS3,2
BP,GO:0031392,regulation of prostaglandin biosynthetic process,2/160,12/18670,0.004552982,0.012398357,0.00580982,PTGS2/IL1B,2
BP,GO:0032042,mitochondrial DNA metabolic process,2/160,12/18670,0.004552982,0.012398357,0.00580982,TP53/PARP1,2
BP,GO:0045472,response to ether,2/160,12/18670,0.004552982,0.012398357,0.00580982,CDK4/MDM2,2
BP,GO:0046541,saliva secretion,2/160,12/18670,0.004552982,0.012398357,0.00580982,CHRM3/CHRM1,2
BP,GO:0060442,branching involved in prostate gland morphogenesis,2/160,12/18670,0.004552982,0.012398357,0.00580982,ESR1/RXRA,2
BP,GO:0060742,epithelial cell differentiation involved in prostate gland development,2/160,12/18670,0.004552982,0.012398357,0.00580982,AR/RXRA,2
BP,GO:0070243,regulation of thymocyte apoptotic process,2/160,12/18670,0.004552982,0.012398357,0.00580982,TP53/HIF1A,2
BP,GO:0070486,leukocyte aggregation,2/160,12/18670,0.004552982,0.012398357,0.00580982,IL1B/CD44,2
BP,GO:0097284,hepatocyte apoptotic process,2/160,12/18670,0.004552982,0.012398357,0.00580982,BCL2L1/RB1,2
BP,GO:0150065,regulation of deacetylase activity,2/160,12/18670,0.004552982,0.012398357,0.00580982,VEGFA/MAPK8,2
BP,GO:1903894,regulation of IRE1-mediated unfolded protein response,2/160,12/18670,0.004552982,0.012398357,0.00580982,BAX/HSPA5,2
BP,GO:1904181,positive regulation of membrane depolarization,2/160,12/18670,0.004552982,0.012398357,0.00580982,KDR/PARP1,2
BP,GO:1905330,regulation of morphogenesis of an epithelium,6/160,180/18670,0.004610891,0.012547515,0.005879715,ESR1/AR/RXRA/VEGFA/STAT1/CXCL10,6
BP,GO:0051147,regulation of muscle cell differentiation,6/160,181/18670,0.004735972,0.012879142,0.006035113,MAPK14/BCL2/PPARA/CXCL10/IGF2/G6PD,6
BP,GO:0035270,endocrine system development,5/160,127/18670,0.004772255,0.012960202,0.006073098,AKT1/IL6R/SLC6A3/MAPK1/RAF1,5
BP,GO:0046887,positive regulation of hormone secretion,5/160,127/18670,0.004772255,0.012960202,0.006073098,EGFR/HIF1A/GJA1/PPARD/SPP1,5
BP,GO:0009268,response to pH,3/160,40/18670,0.004837252,0.013092305,0.006135001,CA2/GJA1/INSRR,3
BP,GO:0044003,modulation by symbiont of host process,3/160,40/18670,0.004837252,0.013092305,0.006135001,RXRA/CASP8/BCL2L1,3
BP,GO:0051281,positive regulation of release of sequestered calcium ion into cytosol,3/160,40/18670,0.004837252,0.013092305,0.006135001,BAX/CXCL11/CXCL10,3
BP,GO:0071470,cellular response to osmotic stress,3/160,40/18670,0.004837252,0.013092305,0.006135001,PTGS2/CASP3/SLC2A4,3
BP,GO:0090184,positive regulation of kidney development,3/160,40/18670,0.004837252,0.013092305,0.006135001,IL6R/VEGFA/MYC,3
BP,GO:0034763,negative regulation of transmembrane transport,5/160,128/18670,0.00493261,0.013341377,0.006251715,AKT1/ADRA2A/MMP9/CAV1/IL1B,5
BP,GO:0002040,sprouting angiogenesis,6/160,183/18670,0.004993611,0.013497247,0.006324755,PTGS2/AKT1/KDR/VEGFA/HMOX1/E2F2,6
BP,GO:0003206,cardiac chamber morphogenesis,5/160,129/18670,0.005096754,0.013766738,0.006451037,RXRA/TP53/HIF1A/NOS3/MDM2,5
BP,GO:0007031,peroxisome organization,4/160,81/18670,0.005182112,0.013934461,0.006529632,NOS2/ACOX1/EHHADH/CAT,4
BP,GO:0032436,positive regulation of proteasomal ubiquitin-dependent protein catabolic process,4/160,81/18670,0.005182112,0.013934461,0.006529632,AKT1/CAV1/NFE2L2/MDM2,4
BP,GO:0110110,positive regulation of animal organ morphogenesis,4/160,81/18670,0.005182112,0.013934461,0.006529632,AR/BAX/VEGFA/MYC,4
BP,GO:1902930,regulation of alcohol biosynthetic process,4/160,81/18670,0.005182112,0.013934461,0.006529632,POR/SOD1/IL1B/IFNG,4
BP,GO:0030890,positive regulation of B cell proliferation,3/160,41/18670,0.005186697,0.013934461,0.006529632,BCL2/CDKN1A/IL4,3
BP,GO:0043403,skeletal muscle tissue regeneration,3/160,41/18670,0.005186697,0.013934461,0.006529632,GJA1/PPARD/PPP3CA,3
BP,GO:0140353,lipid export from cell,3/160,41/18670,0.005186697,0.013934461,0.006529632,NOS2/IL1B/SPP1,3
BP,GO:1900117,regulation of execution phase of apoptosis,3/160,41/18670,0.005186697,0.013934461,0.006529632,BAX/TP53/BCL2L1,3
BP,GO:1902275,regulation of chromatin organization,6/160,185/18670,0.005261408,0.014125155,0.00661899,TP53/VEGFA/IL1B/CCNB1/IGF2/MAPK8,6
BP,GO:0003231,cardiac ventricle development,5/160,130/18670,0.005264734,0.014125155,0.00661899,SCN5A/RXRA/HIF1A/NOS3/MDM2,5
BP,GO:0006705,mineralocorticoid biosynthetic process,2/160,13/18670,0.00535064,0.014165749,0.006638012,HSD3B2/HSD3B1,2
BP,GO:0007171,activation of transmembrane receptor protein tyrosine kinase activity,2/160,13/18670,0.00535064,0.014165749,0.006638012,ADRB2/EGF,2
BP,GO:0008212,mineralocorticoid metabolic process,2/160,13/18670,0.00535064,0.014165749,0.006638012,HSD3B2/HSD3B1,2
BP,GO:0010870,positive regulation of receptor biosynthetic process,2/160,13/18670,0.00535064,0.014165749,0.006638012,HIF1A/IFNG,2
BP,GO:0030656,regulation of vitamin metabolic process,2/160,13/18670,0.00535064,0.014165749,0.006638012,IL1B/IFNG,2
BP,GO:0031650,regulation of heat generation,2/160,13/18670,0.00535064,0.014165749,0.006638012,PTGS2/IL1B,2
BP,GO:0031953,negative regulation of protein autophosphorylation,2/160,13/18670,0.00535064,0.014165749,0.006638012,JUN/CAV1,2
BP,GO:0033127,regulation of histone phosphorylation,2/160,13/18670,0.00535064,0.014165749,0.006638012,IL1B/CCNB1,2
BP,GO:0033145,positive regulation of intracellular steroid hormone receptor signaling pathway,2/160,13/18670,0.00535064,0.014165749,0.006638012,AR/PARP1,2
BP,GO:0043568,positive regulation of insulin-like growth factor receptor signaling pathway,2/160,13/18670,0.00535064,0.014165749,0.006638012,AR/IGFBP3,2
BP,GO:0045086,positive regulation of interleukin-2 biosynthetic process,2/160,13/18670,0.00535064,0.014165749,0.006638012,IL1B/IL1A,2
BP,GO:0050722,regulation of interleukin-1 beta biosynthetic process,2/160,13/18670,0.00535064,0.014165749,0.006638012,IFNG/APP,2
BP,GO:0060576,intestinal epithelial cell development,2/160,13/18670,0.00535064,0.014165749,0.006638012,CDKN1A/HIF1A,2
BP,GO:0061029,eyelid development in camera-type eye,2/160,13/18670,0.00535064,0.014165749,0.006638012,JUN/EGFR,2
BP,GO:0061042,vascular wound healing,2/160,13/18670,0.00535064,0.014165749,0.006638012,SERPINE1/HPSE,2
BP,GO:0061052,negative regulation of cell growth involved in cardiac muscle cell development,2/160,13/18670,0.00535064,0.014165749,0.006638012,PPARA/G6PD,2
BP,GO:0061430,bone trabecula morphogenesis,2/160,13/18670,0.00535064,0.014165749,0.006638012,MMP2/COL1A1,2
BP,GO:0070431,nucleotide-binding oligomerization domain containing 2 signaling pathway,2/160,13/18670,0.00535064,0.014165749,0.006638012,RELA/NFKBIA,2
BP,GO:0071287,cellular response to manganese ion,2/160,13/18670,0.00535064,0.014165749,0.006638012,HSPA5/APP,2
BP,GO:1902947,regulation of tau-protein kinase activity,2/160,13/18670,0.00535064,0.014165749,0.006638012,RB1/IFNG,2
BP,GO:0090049,regulation of cell migration involved in sprouting angiogenesis,4/160,82/18670,0.00541215,0.014309666,0.006705451,PTGS2/KDR/VEGFA/HMOX1,4
BP,GO:1905954,positive regulation of lipid localization,4/160,82/18670,0.00541215,0.014309666,0.006705451,PON1/NFKBIA/IL1B/SPP1,4
BP,GO:0006509,membrane protein ectodomain proteolysis,3/160,42/18670,0.005550966,0.014638021,0.006859317,ADRA2A/IL1B/IFNG,3
BP,GO:0010613,positive regulation of cardiac muscle hypertrophy,3/160,42/18670,0.005550966,0.014638021,0.006859317,PRKCA/PARP1/PPP3CA,3
BP,GO:0051154,negative regulation of striated muscle cell differentiation,3/160,42/18670,0.005550966,0.014638021,0.006859317,PPARA/CXCL10/G6PD,3
BP,GO:1903146,regulation of autophagy of mitochondrion,3/160,42/18670,0.005550966,0.014638021,0.006859317,TP53/HIF1A/HK2,3
BP,GO:0006165,nucleoside diphosphate phosphorylation,5/160,132/18670,0.005612393,0.014790263,0.006930657,HIF1A/IFNG/PPARA/HK2/APP,5
BP,GO:0042509,regulation of tyrosine phosphorylation of STAT protein,4/160,83/18670,0.005648919,0.014866944,0.00696659,IL6R/IL4/CAV1/IFNG,4
BP,GO:0071277,cellular response to calcium ion,4/160,83/18670,0.005648919,0.014866944,0.00696659,SCN5A/JUN/FOS/HSPA5,4
BP,GO:0006575,cellular modified amino acid metabolic process,6/160,188/18670,0.005682658,0.0149361,0.006998996,POR/SOD1/GSTP1/NFE2L2/GSTM1/G6PD,6
BP,GO:0051783,regulation of nuclear division,6/160,188/18670,0.005682658,0.0149361,0.006998996,EGF/RB1/IL1B/CCNB1/IL1A/IGF2,6
BP,GO:0021537,telencephalon development,7/160,249/18670,0.005733247,0.01505918,0.00705667,SCN5A/BAX/CASP3/EGFR/HIF1A/HSD3B2/HSD3B1,7
BP,GO:0071333,cellular response to glucose stimulus,5/160,133/18670,0.005792166,0.015203961,0.007124514,ADRA2A/RAF1/HIF1A/ICAM1/PPP3CA,5
BP,GO:0010863,positive regulation of phospholipase C activity,3/160,43/18670,0.005930225,0.015515483,0.007270492,ESR1/EGFR/SELE,3
BP,GO:0014742,positive regulation of muscle hypertrophy,3/160,43/18670,0.005930225,0.015515483,0.007270492,PRKCA/PARP1/PPP3CA,3
BP,GO:0032881,regulation of polysaccharide metabolic process,3/160,43/18670,0.005930225,0.015515483,0.007270492,AKT1/EGF/IGF2,3
BP,GO:0034198,cellular response to amino acid starvation,3/160,43/18670,0.005930225,0.015515483,0.007270492,CDKN1A/MAPK1/MAPK8,3
BP,GO:0055026,negative regulation of cardiac muscle tissue development,3/160,43/18670,0.005930225,0.015515483,0.007270492,GJA1/PPARA/G6PD,3
BP,GO:0009135,purine nucleoside diphosphate metabolic process,5/160,134/18670,0.005975963,0.015604554,0.00731223,HIF1A/IFNG/PPARA/HK2/APP,5
BP,GO:0009179,purine ribonucleoside diphosphate metabolic process,5/160,134/18670,0.005975963,0.015604554,0.00731223,HIF1A/IFNG/PPARA/HK2/APP,5
BP,GO:0046939,nucleotide phosphorylation,5/160,134/18670,0.005975963,0.015604554,0.00731223,HIF1A/IFNG/PPARA/HK2/APP,5
BP,GO:0002028,regulation of sodium ion transport,4/160,85/18670,0.006142993,0.016010586,0.007502496,SCN5A/ADRB2/AKT1/NOS3,4
BP,GO:0014031,mesenchymal cell development,4/160,85/18670,0.006142993,0.016010586,0.007502496,BCL2/FN1/MAPK1/HIF1A,4
BP,GO:0071331,cellular response to hexose stimulus,5/160,135/18670,0.006163832,0.016010586,0.007502496,ADRA2A/RAF1/HIF1A/ICAM1/PPP3CA,5
BP,GO:0014854,response to inactivity,2/160,14/18670,0.006207452,0.016010586,0.007502496,SCN5A/CAT,2
BP,GO:0020027,hemoglobin metabolic process,2/160,14/18670,0.006207452,0.016010586,0.007502496,HIF1A/CAT,2
BP,GO:0030213,hyaluronan biosynthetic process,2/160,14/18670,0.006207452,0.016010586,0.007502496,EGF/IL1B,2
BP,GO:0032310,prostaglandin secretion,2/160,14/18670,0.006207452,0.016010586,0.007502496,NOS2/IL1B,2
BP,GO:0036295,cellular response to increased oxygen levels,2/160,14/18670,0.006207452,0.016010586,0.007502496,PPARG/CAV1,2
BP,GO:0038166,angiotensin-activated signaling pathway,2/160,14/18670,0.006207452,0.016010586,0.007502496,CA2/CAV1,2
BP,GO:0043374,"CD8-positive, alpha-beta T cell differentiation",2/160,14/18670,0.006207452,0.016010586,0.007502496,BCL2/IRF1,2
BP,GO:0045346,regulation of MHC class II biosynthetic process,2/160,14/18670,0.006207452,0.016010586,0.007502496,IL4/IFNG,2
BP,GO:0050720,interleukin-1 beta biosynthetic process,2/160,14/18670,0.006207452,0.016010586,0.007502496,IFNG/APP,2
BP,GO:0050930,induction of positive chemotaxis,2/160,14/18670,0.006207452,0.016010586,0.007502496,CXCL8/VEGFA,2
BP,GO:0051712,positive regulation of killing of cells of other organism,2/160,14/18670,0.006207452,0.016010586,0.007502496,NOS2/IFNG,2
BP,GO:0051917,regulation of fibrinolysis,2/160,14/18670,0.006207452,0.016010586,0.007502496,THBD/SERPINE1,2
BP,GO:0071391,cellular response to estrogen stimulus,2/160,14/18670,0.006207452,0.016010586,0.007502496,ESR1/MDM2,2
BP,GO:0106070,regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway,2/160,14/18670,0.006207452,0.016010586,0.007502496,OPRM1/PRKCA,2
BP,GO:1901722,regulation of cell proliferation involved in kidney development,2/160,14/18670,0.006207452,0.016010586,0.007502496,IL6R/MYC,2
BP,GO:2001279,regulation of unsaturated fatty acid biosynthetic process,2/160,14/18670,0.006207452,0.016010586,0.007502496,PTGS2/IL1B,2
BP,GO:1901888,regulation of cell junction assembly,6/160,192/18670,0.006282038,0.016192529,0.007587753,KDR/VEGFA/CAV1/GJA1/APP/IKBKB,6
BP,GO:0003197,endocardial cushion development,3/160,44/18670,0.006324631,0.016229166,0.007604921,NOS3/ERBB3/MDM2,3
BP,GO:0010463,mesenchymal cell proliferation,3/160,44/18670,0.006324631,0.016229166,0.007604921,VEGFA/STAT1/MYC,3
BP,GO:0010828,positive regulation of glucose transmembrane transport,3/160,44/18670,0.006324631,0.016229166,0.007604921,MAPK14/AKT1/NFE2L2,3
BP,GO:0038084,vascular endothelial growth factor signaling pathway,3/160,44/18670,0.006324631,0.016229166,0.007604921,KDR/VEGFA/HSPB1,3
BP,GO:0042987,amyloid precursor protein catabolic process,3/160,44/18670,0.006324631,0.016229166,0.007604921,CASP3/IFNG/APP,3
BP,GO:0045601,regulation of endothelial cell differentiation,3/160,44/18670,0.006324631,0.016229166,0.007604921,VEGFA/IL1B/IKBKB,3
BP,GO:0070266,necroptotic process,3/160,44/18670,0.006324631,0.016229166,0.007604921,TP53/CASP8/CAV1,3
BP,GO:0007292,female gamete generation,5/160,136/18670,0.006355817,0.016277887,0.007627751,PTGS2/BCL2/PGR/NOS3/CCNB1,5
BP,GO:0009185,ribonucleoside diphosphate metabolic process,5/160,136/18670,0.006355817,0.016277887,0.007627751,HIF1A/IFNG/PPARA/HK2/APP,5
BP,GO:0071326,cellular response to monosaccharide stimulus,5/160,136/18670,0.006355817,0.016277887,0.007627751,ADRA2A/RAF1/HIF1A/ICAM1/PPP3CA,5
BP,GO:0001942,hair follicle development,4/160,86/18670,0.006400466,0.016371287,0.007671518,RELA/BCL2/EGFR/HPSE,4
BP,GO:0007260,tyrosine phosphorylation of STAT protein,4/160,86/18670,0.006400466,0.016371287,0.007671518,IL6R/IL4/CAV1/IFNG,4
BP,GO:0010675,regulation of cellular carbohydrate metabolic process,5/160,137/18670,0.006551967,0.016726737,0.007838081,AKT1/TP53/PPARA/IGFBP3/IGF2,5
BP,GO:0031644,regulation of nervous system process,5/160,137/18670,0.006551967,0.016726737,0.007838081,ADRB2/OPRM1/ADRA2C/NOS3/APP,5
BP,GO:1903670,regulation of sprouting angiogenesis,5/160,137/18670,0.006551967,0.016726737,0.007838081,PTGS2/KDR/VEGFA/HMOX1/E2F2,5
BP,GO:0002697,regulation of immune effector process,10/160,462/18670,0.006588103,0.01680827,0.007876287,NOS2/MAPK14/IL4/STAT1/HMOX1/ICAM1/IL1B/IL2RA/IFNG/CD40LG,10
BP,GO:0001974,blood vessel remodeling,3/160,45/18670,0.006734336,0.017148568,0.008035749,BAX/NOS3/MDM2,3
BP,GO:0035987,endodermal cell differentiation,3/160,45/18670,0.006734336,0.017148568,0.008035749,FN1/MMP2/MMP9,3
BP,GO:1900274,regulation of phospholipase C activity,3/160,45/18670,0.006734336,0.017148568,0.008035749,ESR1/EGFR/SELE,3
BP,GO:0048863,stem cell differentiation,7/160,257/18670,0.006780175,0.017254318,0.008085303,ESR1/TP53/FN1/MAPK1/HIF1A/NFE2L2/RUNX2,7
BP,GO:0009791,post-embryonic development,4/160,88/18670,0.006936692,0.017596692,0.008245738,BCL2/BAX/CYP1A2/VEGFA,4
BP,GO:0022404,molting cycle process,4/160,88/18670,0.006936692,0.017596692,0.008245738,RELA/BCL2/EGFR/HPSE,4
BP,GO:0022405,hair cycle process,4/160,88/18670,0.006936692,0.017596692,0.008245738,RELA/BCL2/EGFR/HPSE,4
BP,GO:0032088,negative regulation of NF-kappaB transcription factor activity,4/160,88/18670,0.006936692,0.017596692,0.008245738,NFKBIA/CYP1B1/CHUK/CAT,4
BP,GO:0098773,skin epidermis development,4/160,88/18670,0.006936692,0.017596692,0.008245738,RELA/BCL2/EGFR/HPSE,4
BP,GO:0002700,regulation of production of molecular mediator of immune response,5/160,139/18670,0.006956939,0.017636877,0.008264568,MAPK14/IL4/HMOX1/IL1B/CD40LG,5
BP,GO:0021924,cell proliferation in external granule layer,2/160,15/18670,0.007122358,0.017872219,0.008374849,SLC6A4/EGF,2
BP,GO:0021930,cerebellar granule cell precursor proliferation,2/160,15/18670,0.007122358,0.017872219,0.008374849,SLC6A4/EGF,2
BP,GO:0030238,male sex determination,2/160,15/18670,0.007122358,0.017872219,0.008374849,AR/INSRR,2
BP,GO:0033540,fatty acid beta-oxidation using acyl-CoA oxidase,2/160,15/18670,0.007122358,0.017872219,0.008374849,ACOX1/EHHADH,2
BP,GO:0042976,activation of Janus kinase activity,2/160,15/18670,0.007122358,0.017872219,0.008374849,IL6R/IL4,2
BP,GO:0043518,"negative regulation of DNA damage response, signal transduction by p53 class mediator",2/160,15/18670,0.007122358,0.017872219,0.008374849,CD44/MDM2,2
BP,GO:0045342,MHC class II biosynthetic process,2/160,15/18670,0.007122358,0.017872219,0.008374849,IL4/IFNG,2
BP,GO:0045360,regulation of interleukin-1 biosynthetic process,2/160,15/18670,0.007122358,0.017872219,0.008374849,IFNG/APP,2
BP,GO:0045410,positive regulation of interleukin-6 biosynthetic process,2/160,15/18670,0.007122358,0.017872219,0.008374849,IL1B/APP,2
BP,GO:0045898,regulation of RNA polymerase II transcription preinitiation complex assembly,2/160,15/18670,0.007122358,0.017872219,0.008374849,ESR1/TP53,2
BP,GO:0046321,positive regulation of fatty acid oxidation,2/160,15/18670,0.007122358,0.017872219,0.008374849,PPARG/PPARA,2
BP,GO:0048070,regulation of developmental pigmentation,2/160,15/18670,0.007122358,0.017872219,0.008374849,BCL2/BAX,2
BP,GO:0048569,post-embryonic animal organ development,2/160,15/18670,0.007122358,0.017872219,0.008374849,BAX/VEGFA,2
BP,GO:0072075,metanephric mesenchyme development,2/160,15/18670,0.007122358,0.017872219,0.008374849,STAT1/MYC,2
BP,GO:1900119,positive regulation of execution phase of apoptosis,2/160,15/18670,0.007122358,0.017872219,0.008374849,BAX/TP53,2
BP,GO:2000402,negative regulation of lymphocyte migration,2/160,15/18670,0.007122358,0.017872219,0.008374849,AKT1/CCL2,2
BP,GO:0002437,inflammatory response to antigenic stimulus,3/160,46/18670,0.007159483,0.017872219,0.008374849,OPRM1/ICAM1/IL2RA,3
BP,GO:0007157,heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules,3/160,46/18670,0.007159483,0.017872219,0.008374849,ICAM1/SELE/VCAM1,3
BP,GO:0014075,response to amine,3/160,46/18670,0.007159483,0.017872219,0.008374849,SOD1/ICAM1/PPP3CA,3
BP,GO:0043330,response to exogenous dsRNA,3/160,46/18670,0.007159483,0.017872219,0.008374849,MAPK1/NFKBIA/CAV1,3
BP,GO:0060711,labyrinthine layer development,3/160,46/18670,0.007159483,0.017872219,0.008374849,AKT1/CASP8/MAPK1,3
BP,GO:0071675,regulation of mononuclear cell migration,3/160,46/18670,0.007159483,0.017872219,0.008374849,MAPK14/SERPINE1/CXCL10,3
BP,GO:1990928,response to amino acid starvation,3/160,46/18670,0.007159483,0.017872219,0.008374849,CDKN1A/MAPK1/MAPK8,3
BP,GO:0046330,positive regulation of JNK cascade,5/160,140/18670,0.007165854,0.017872219,0.008374849,IL1B/NCF1/CD40LG/APP/MAP2K4,5
BP,GO:0072073,kidney epithelium development,5/160,140/18670,0.007165854,0.017872219,0.008374849,BCL2/VEGFA/STAT1/MYC/CAT,5
BP,GO:1903364,positive regulation of cellular protein catabolic process,5/160,140/18670,0.007165854,0.017872219,0.008374849,AKT1/EGF/CAV1/NFE2L2/MDM2,5
BP,GO:0016052,carbohydrate catabolic process,6/160,198/18670,0.00726566,0.018098592,0.008480926,TP53/HIF1A/IFNG/PPARA/HK2/APP,6
BP,GO:0060541,respiratory system development,6/160,198/18670,0.00726566,0.018098592,0.008480926,PGR/CYP1A2/EGFR/VEGFA/MAPK1/NOS3,6
BP,GO:0050709,negative regulation of protein secretion,5/160,141/18670,0.007379113,0.01836977,0.008608,FN1/OPRM1/ADRA2A/IL1B/PPP3CA,5
BP,GO:0019058,viral life cycle,8/160,328/18670,0.007428541,0.018481322,0.008660272,DPP4/BCL2/CCL2/CXCL8/EGFR/CAV1/ICAM1/SLPI,8
BP,GO:0007179,transforming growth factor beta receptor signaling pathway,6/160,199/18670,0.007439829,0.01849791,0.008668045,JUN/TP53/FOS/HSPA5/CAV1/PARP1,6
BP,GO:0031058,positive regulation of histone modification,4/160,90/18670,0.007501828,0.018628919,0.008729436,TP53/VEGFA/IL1B/CCNB1,4
BP,GO:0043255,regulation of carbohydrate biosynthetic process,4/160,90/18670,0.007501828,0.018628919,0.008729436,AKT1/EGF/PPARA/IGF2,4
BP,GO:0009150,purine ribonucleotide metabolic process,9/160,399/18670,0.007573197,0.018745307,0.008783975,IL4/HIF1A/SULT1E1/IFNG/PARP1/PPARA/HK2/APP/ADCY2,9
BP,GO:0008277,regulation of G protein-coupled receptor signaling pathway,5/160,142/18670,0.007596764,0.018745307,0.008783975,ADRB2/CXCL8/OPRM1/PRKCA/MET,5
BP,GO:0072006,nephron development,5/160,142/18670,0.007596764,0.018745307,0.008783975,BCL2/IL6R/VEGFA/STAT1/MYC,5
BP,GO:0010799,regulation of peptidyl-threonine phosphorylation,3/160,47/18670,0.007600208,0.018745307,0.008783975,MAPK1/EGF/APP,3
BP,GO:0031952,regulation of protein autophosphorylation,3/160,47/18670,0.007600208,0.018745307,0.008783975,JUN/VEGFA/CAV1,3
BP,GO:0042551,neuron maturation,3/160,47/18670,0.007600208,0.018745307,0.008783975,BCL2/RB1/APP,3
BP,GO:0045646,regulation of erythrocyte differentiation,3/160,47/18670,0.007600208,0.018745307,0.008783975,MAPK14/HIF1A/STAT1,3
BP,GO:0048066,developmental pigmentation,3/160,47/18670,0.007600208,0.018745307,0.008783975,BCL2/BAX/TYR,3
BP,GO:0048806,genitalia development,3/160,47/18670,0.007600208,0.018745307,0.008783975,ESR1/AR/BAX,3
BP,GO:0050435,amyloid-beta metabolic process,3/160,47/18670,0.007600208,0.018745307,0.008783975,CASP3/IFNG/APP,3
BP,GO:1900744,regulation of p38MAPK cascade,3/160,47/18670,0.007600208,0.018745307,0.008783975,VEGFA/IL1B/NCF1,3
BP,GO:0034248,regulation of cellular amide metabolic process,10/160,476/18670,0.008049534,0.019696979,0.009229924,RXRA/AKT1/CASP3/MAPK1/ERBB2/HSPB1/IFNG/NFE2L2/CDK4/APP,10
BP,GO:0001774,microglial cell activation,3/160,48/18670,0.00805664,0.019696979,0.009229924,JUN/IFNG/APP,3
BP,GO:0002269,leukocyte activation involved in inflammatory response,3/160,48/18670,0.00805664,0.019696979,0.009229924,JUN/IFNG/APP,3
BP,GO:0030850,prostate gland development,3/160,48/18670,0.00805664,0.019696979,0.009229924,ESR1/AR/RXRA,3
BP,GO:0045933,positive regulation of muscle contraction,3/160,48/18670,0.00805664,0.019696979,0.009229924,PTGS2/CHRM3/ADRA2B,3
BP,GO:0055023,positive regulation of cardiac muscle tissue growth,3/160,48/18670,0.00805664,0.019696979,0.009229924,MAPK14/MAPK1/CCNB1,3
BP,GO:0010225,response to UV-C,2/160,16/18670,0.008094312,0.019696979,0.009229924,TP53/MDM2,2
BP,GO:0010875,positive regulation of cholesterol efflux,2/160,16/18670,0.008094312,0.019696979,0.009229924,PON1/NFKBIA,2
BP,GO:0016540,protein autoprocessing,2/160,16/18670,0.008094312,0.019696979,0.009229924,PARP1/CASP1,2
BP,GO:0021534,cell proliferation in hindbrain,2/160,16/18670,0.008094312,0.019696979,0.009229924,SLC6A4/EGF,2
BP,GO:0030397,membrane disassembly,2/160,16/18670,0.008094312,0.019696979,0.009229924,PRKCA/CCNB1,2
BP,GO:0032225,"regulation of synaptic transmission, dopaminergic",2/160,16/18670,0.008094312,0.019696979,0.009229924,PTGS2/SLC6A4,2
BP,GO:0034116,positive regulation of heterotypic cell-cell adhesion,2/160,16/18670,0.008094312,0.019696979,0.009229924,IL1B/CD44,2
BP,GO:0042222,interleukin-1 biosynthetic process,2/160,16/18670,0.008094312,0.019696979,0.009229924,IFNG/APP,2
BP,GO:0043217,myelin maintenance,2/160,16/18670,0.008094312,0.019696979,0.009229924,AKT1/SOD1,2
BP,GO:0051081,nuclear envelope disassembly,2/160,16/18670,0.008094312,0.019696979,0.009229924,PRKCA/CCNB1,2
BP,GO:0055012,ventricular cardiac muscle cell differentiation,2/160,16/18670,0.008094312,0.019696979,0.009229924,RXRA/CCNB1,2
BP,GO:0071380,cellular response to prostaglandin E stimulus,2/160,16/18670,0.008094312,0.019696979,0.009229924,PPARG/AKT1,2
BP,GO:0090335,regulation of brown fat cell differentiation,2/160,16/18670,0.008094312,0.019696979,0.009229924,PTGS2/MAPK14,2
BP,GO:1902166,negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator,2/160,16/18670,0.008094312,0.019696979,0.009229924,BCL2/CD44,2
BP,GO:1904294,positive regulation of ERAD pathway,2/160,16/18670,0.008094312,0.019696979,0.009229924,CAV1/NFE2L2,2
BP,GO:1990000,amyloid fibril formation,2/160,16/18670,0.008094312,0.019696979,0.009229924,MDM2/APP,2
BP,GO:0007605,sensory perception of sound,5/160,145/18670,0.008276503,0.020115871,0.009426215,CASP3/SOD1/ICAM1/BIRC5/COL1A1,5
BP,GO:0007612,learning,5/160,145/18670,0.008276503,0.020115871,0.009426215,PTGS2/JUN/FOS/HIF1A/APP,5
BP,GO:0006476,protein deacetylation,4/160,93/18670,0.008405097,0.020391274,0.009555268,TP53/VEGFA/IFNG/MAPK8,4
BP,GO:0062207,regulation of pattern recognition receptor signaling pathway,4/160,93/18670,0.008405097,0.020391274,0.009555268,ESR1/CAV1/IRF1/XIAP,4
BP,GO:0072080,nephron tubule development,4/160,93/18670,0.008405097,0.020391274,0.009555268,BCL2/VEGFA/STAT1/MYC,4
BP,GO:0002686,negative regulation of leukocyte migration,3/160,49/18670,0.008528902,0.020666583,0.009684276,AKT1/CCL2/HMOX1,3
BP,GO:0048546,digestive tract morphogenesis,3/160,49/18670,0.008528902,0.020666583,0.009684276,BCL2/EGFR/HIF1A,3
BP,GO:0060993,kidney morphogenesis,4/160,94/18670,0.008721305,0.021094492,0.009884793,BCL2/VEGFA/STAT1/MYC,4
BP,GO:0070167,regulation of biomineral tissue development,4/160,94/18670,0.008721305,0.021094492,0.009884793,ADRB2/HIF1A/GJA1/NOS3,4
BP,GO:0110149,regulation of biomineralization,4/160,94/18670,0.008721305,0.021094492,0.009884793,ADRB2/HIF1A/GJA1/NOS3,4
BP,GO:0090263,positive regulation of canonical Wnt signaling pathway,5/160,147/18670,0.008752425,0.021156979,0.009914074,EGFR/EGF/CAV1/COL1A1/XIAP,5
BP,GO:0045165,cell fate commitment,7/160,271/18670,0.008945746,0.021611237,0.010126938,AR/PPARG/BCL2/CASP3/TP53/MCL1/RUNX2,7
BP,GO:0002792,negative regulation of peptide secretion,5/160,148/18670,0.008997346,0.021705042,0.010170894,FN1/OPRM1/ADRA2A/IL1B/PPP3CA,5
BP,GO:0001706,endoderm formation,3/160,50/18670,0.009017108,0.021705042,0.010170894,FN1/MMP2/MMP9,3
BP,GO:0014009,glial cell proliferation,3/160,50/18670,0.009017108,0.021705042,0.010170894,CHRM1/IL1B/E2F1,3
BP,GO:0032873,negative regulation of stress-activated MAPK cascade,3/160,50/18670,0.009017108,0.021705042,0.010170894,AKT1/MYC/GSTP1,3
BP,GO:0070303,negative regulation of stress-activated protein kinase signaling cascade,3/160,50/18670,0.009017108,0.021705042,0.010170894,AKT1/MYC/GSTP1,3
BP,GO:0086009,membrane repolarization,3/160,50/18670,0.009017108,0.021705042,0.010170894,SCN5A/CAV1/GJA1,3
BP,GO:0050810,regulation of steroid biosynthetic process,4/160,95/18670,0.009045195,0.021746496,0.010190319,POR/SOD1/IL1B/IFNG,4
BP,GO:0061326,renal tubule development,4/160,95/18670,0.009045195,0.021746496,0.010190319,BCL2/VEGFA/STAT1/MYC,4
BP,GO:0006089,lactate metabolic process,2/160,17/18670,0.009122281,0.021748953,0.010191471,TP53/HIF1A,2
BP,GO:0015732,prostaglandin transport,2/160,17/18670,0.009122281,0.021748953,0.010191471,NOS2/IL1B,2
BP,GO:0017085,response to insecticide,2/160,17/18670,0.009122281,0.021748953,0.010191471,CYP1A1/CCNB1,2
BP,GO:0030540,female genitalia development,2/160,17/18670,0.009122281,0.021748953,0.010191471,ESR1/BAX,2
BP,GO:0032966,negative regulation of collagen biosynthetic process,2/160,17/18670,0.009122281,0.021748953,0.010191471,PPARG/PPARD,2
BP,GO:0033599,regulation of mammary gland epithelial cell proliferation,2/160,17/18670,0.009122281,0.021748953,0.010191471,CCND1/BAX,2
BP,GO:0045725,positive regulation of glycogen biosynthetic process,2/160,17/18670,0.009122281,0.021748953,0.010191471,AKT1/IGF2,2
BP,GO:0051709,regulation of killing of cells of other organism,2/160,17/18670,0.009122281,0.021748953,0.010191471,NOS2/IFNG,2
BP,GO:0055070,copper ion homeostasis,2/160,17/18670,0.009122281,0.021748953,0.010191471,APP/XIAP,2
BP,GO:0060644,mammary gland epithelial cell differentiation,2/160,17/18670,0.009122281,0.021748953,0.010191471,AKT1/HIF1A,2
BP,GO:0061298,retina vasculature development in camera-type eye,2/160,17/18670,0.009122281,0.021748953,0.010191471,HIF1A/CYP1B1,2
BP,GO:0071850,mitotic cell cycle arrest,2/160,17/18670,0.009122281,0.021748953,0.010191471,CDKN1A/TP53,2
BP,GO:0090185,negative regulation of kidney development,2/160,17/18670,0.009122281,0.021748953,0.010191471,MMP9/STAT1,2
BP,GO:1904996,positive regulation of leukocyte adhesion to vascular endothelial cell,2/160,17/18670,0.009122281,0.021748953,0.010191471,RELA/ICAM1,2
BP,GO:2000058,regulation of ubiquitin-dependent protein catabolic process,5/160,149/18670,0.009246963,0.022033091,0.010324617,AKT1/EGF/CAV1/NFE2L2/MDM2,5
BP,GO:0090277,positive regulation of peptide hormone secretion,4/160,96/18670,0.009376838,0.022329257,0.010463399,EGFR/HIF1A/GJA1/PPARD,4
BP,GO:0006090,pyruvate metabolic process,5/160,150/18670,0.00950132,0.022585382,0.010583418,HIF1A/IFNG/PPARA/HK2/APP,5
BP,GO:0008360,regulation of cell shape,5/160,150/18670,0.00950132,0.022585382,0.010583418,KDR/CCL2/FN1/VEGFA/ICAM1,5
BP,GO:0061351,neural precursor cell proliferation,5/160,150/18670,0.00950132,0.022585382,0.010583418,TP53/SLC6A4/VEGFA/EGF/HIF1A,5
BP,GO:0009259,ribonucleotide metabolic process,9/160,414/18670,0.009512072,0.022597521,0.010589106,IL4/HIF1A/SULT1E1/IFNG/PARP1/PPARA/HK2/APP/ADCY2,9
BP,GO:0031103,axon regeneration,3/160,51/18670,0.009521369,0.022606192,0.010593169,BCL2/JUN/SPP1,3
BP,GO:0001657,ureteric bud development,4/160,97/18670,0.009716303,0.023028041,0.010790846,BCL2/VEGFA/MYC/CAT,4
BP,GO:0007044,cell-substrate junction assembly,4/160,97/18670,0.009716303,0.023028041,0.010790846,BCL2/KDR/FN1/VEGFA,4
BP,GO:0150115,cell-substrate junction organization,4/160,97/18670,0.009716303,0.023028041,0.010790846,BCL2/KDR/FN1/VEGFA,4
BP,GO:1903169,regulation of calcium ion transmembrane transport,5/160,152/18670,0.01002442,0.02369696,0.011104299,BAX/ADRA2A/CXCL11/CXCL10/G6PD,5
BP,GO:0003179,heart valve morphogenesis,3/160,52/18670,0.010041786,0.02369696,0.011104299,RB1/NOS3/MDM2,3
BP,GO:0032330,regulation of chondrocyte differentiation,3/160,52/18670,0.010041786,0.02369696,0.011104299,RELA/POR/RUNX2,3
BP,GO:0060421,positive regulation of heart growth,3/160,52/18670,0.010041786,0.02369696,0.011104299,MAPK14/MAPK1/CCNB1,3
BP,GO:0072132,mesenchyme morphogenesis,3/160,52/18670,0.010041786,0.02369696,0.011104299,MYC/NOS3/MDM2,3
BP,GO:2000179,positive regulation of neural precursor cell proliferation,3/160,52/18670,0.010041786,0.02369696,0.011104299,VEGFA/EGF/HIF1A,3
BP,GO:2000677,regulation of transcription regulatory region DNA binding,3/160,52/18670,0.010041786,0.02369696,0.011104299,RB1/IFNG/PARP1,3
BP,GO:0031341,regulation of cell killing,4/160,98/18670,0.01006366,0.02369696,0.011104299,NOS2/IL4/ICAM1/IFNG,4
BP,GO:0060191,regulation of lipase activity,4/160,98/18670,0.01006366,0.02369696,0.011104299,ESR1/EGFR/POR/SELE,4
BP,GO:0072163,mesonephric epithelium development,4/160,98/18670,0.01006366,0.02369696,0.011104299,BCL2/VEGFA/MYC/CAT,4
BP,GO:0072164,mesonephric tubule development,4/160,98/18670,0.01006366,0.02369696,0.011104299,BCL2/VEGFA/MYC/CAT,4
BP,GO:0009165,nucleotide biosynthetic process,7/160,278/18670,0.010201477,0.023794002,0.011149772,NOS2/PTGS2/IL4/MAPK1/NOS3/PARP1/ADCY2,7
BP,GO:0006704,glucocorticoid biosynthetic process,2/160,18/18670,0.010205247,0.023794002,0.011149772,HSD3B2/HSD3B1,2
BP,GO:0010713,negative regulation of collagen metabolic process,2/160,18/18670,0.010205247,0.023794002,0.011149772,PPARG/PPARD,2
BP,GO:0019054,modulation by virus of host cellular process,2/160,18/18670,0.010205247,0.023794002,0.011149772,CASP8/BCL2L1,2
BP,GO:0031065,positive regulation of histone deacetylation,2/160,18/18670,0.010205247,0.023794002,0.011149772,TP53/VEGFA,2
BP,GO:0031998,regulation of fatty acid beta-oxidation,2/160,18/18670,0.010205247,0.023794002,0.011149772,AKT1/PPARA,2
BP,GO:0070230,positive regulation of lymphocyte apoptotic process,2/160,18/18670,0.010205247,0.023794002,0.011149772,BAX/TP53,2
BP,GO:0070875,positive regulation of glycogen metabolic process,2/160,18/18670,0.010205247,0.023794002,0.011149772,AKT1/IGF2,2
BP,GO:0071318,cellular response to ATP,2/160,18/18670,0.010205247,0.023794002,0.011149772,PTGS2/SOD1,2
BP,GO:0071371,cellular response to gonadotropin stimulus,2/160,18/18670,0.010205247,0.023794002,0.011149772,CCNA2/POR,2
BP,GO:0071605,monocyte chemotactic protein-1 production,2/160,18/18670,0.010205247,0.023794002,0.011149772,IL1B/GSTP1,2
BP,GO:0071637,regulation of monocyte chemotactic protein-1 production,2/160,18/18670,0.010205247,0.023794002,0.011149772,IL1B/GSTP1,2
BP,GO:0090026,positive regulation of monocyte chemotaxis,2/160,18/18670,0.010205247,0.023794002,0.011149772,SERPINE1/CXCL10,2
BP,GO:1900221,regulation of amyloid-beta clearance,2/160,18/18670,0.010205247,0.023794002,0.011149772,IL4/IFNG,2
BP,GO:1900543,negative regulation of purine nucleotide metabolic process,2/160,18/18670,0.010205247,0.023794002,0.011149772,PARP1/PPARA,2
BP,GO:1902165,regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator,2/160,18/18670,0.010205247,0.023794002,0.011149772,BCL2/CD44,2
BP,GO:1902749,regulation of cell cycle G2/M phase transition,6/160,213/18670,0.010205921,0.023794002,0.011149772,CDK2/CCND1/TP53/CCNB1/CDK4/APP,6
BP,GO:0050729,positive regulation of inflammatory response,5/160,153/18670,0.010293246,0.023983624,0.011238628,PTGS2/EGFR/NFKBIA/IL1B/SERPINE1,5
BP,GO:0030301,cholesterol transport,4/160,99/18670,0.010418977,0.024248351,0.011362678,PON1/EGF/NFKBIA/CAV1,4
BP,GO:0051817,modulation of process of other organism involved in symbiotic interaction,4/160,99/18670,0.010418977,0.024248351,0.011362678,RXRA/JUN/CASP8/BCL2L1,4
BP,GO:0009132,nucleoside diphosphate metabolic process,5/160,154/18670,0.010566979,0.02451972,0.011489841,HIF1A/IFNG/PPARA/HK2/APP,5
BP,GO:0010043,response to zinc ion,3/160,53/18670,0.010578455,0.02451972,0.011489841,CA2/VCAM1/PARP1,3
BP,GO:0010823,negative regulation of mitochondrion organization,3/160,53/18670,0.010578455,0.02451972,0.011489841,AKT1/TP53/BCL2L1,3
BP,GO:0032964,collagen biosynthetic process,3/160,53/18670,0.010578455,0.02451972,0.011489841,PPARG/COL1A1/PPARD,3
BP,GO:0043331,response to dsRNA,3/160,53/18670,0.010578455,0.02451972,0.011489841,MAPK1/NFKBIA/CAV1,3
BP,GO:0070228,regulation of lymphocyte apoptotic process,3/160,53/18670,0.010578455,0.02451972,0.011489841,BAX/TP53/HIF1A,3
BP,GO:1901185,negative regulation of ERBB signaling pathway,3/160,53/18670,0.010578455,0.02451972,0.011489841,EGFR/EGF/ERBB2,3
BP,GO:0007200,phospholipase C-activating G protein-coupled receptor signaling pathway,4/160,100/18670,0.010782319,0.024977791,0.011704491,ESR1/CHRM1/OPRM1/ADRA2A,4
BP,GO:0060047,heart contraction,7/160,282/18670,0.010974337,0.025393221,0.01189916,SCN5A/ADRB1/SOD1/CAV1/GJA1/NOS3/MDM2,7
BP,GO:1901293,nucleoside phosphate biosynthetic process,7/160,282/18670,0.010974337,0.025393221,0.01189916,NOS2/PTGS2/IL4/MAPK1/NOS3/PARP1/ADCY2,7
BP,GO:0030199,collagen fibril organization,3/160,54/18670,0.011131468,0.025741921,0.012062559,RB1/CYP1B1/COL1A1,3
BP,GO:0002027,regulation of heart rate,4/160,101/18670,0.011153752,0.025778561,0.012079729,SCN5A/ADRB1/CAV1/MDM2,4
BP,GO:0002076,osteoblast development,2/160,19/18670,0.011342204,0.025944481,0.012157478,ACHE/RUNX2,2
BP,GO:0002544,chronic inflammatory response,2/160,19/18670,0.011342204,0.025944481,0.012157478,GJA1/VCAM1,2
BP,GO:0003085,negative regulation of systemic arterial blood pressure,2/160,19/18670,0.011342204,0.025944481,0.012157478,ADRB2/ADRB1,2
BP,GO:0010544,negative regulation of platelet activation,2/160,19/18670,0.011342204,0.025944481,0.012157478,NOS3/THBD,2
BP,GO:0015669,gas transport,2/160,19/18670,0.011342204,0.025944481,0.012157478,CA2/MYC,2
BP,GO:0032026,response to magnesium ion,2/160,19/18670,0.011342204,0.025944481,0.012157478,CCND1/MDM2,2
BP,GO:0032095,regulation of response to food,2/160,19/18670,0.011342204,0.025944481,0.012157478,OPRM1/PPARA,2
BP,GO:0034138,toll-like receptor 3 signaling pathway,2/160,19/18670,0.011342204,0.025944481,0.012157478,CASP8/CAV1,2
BP,GO:0045076,regulation of interleukin-2 biosynthetic process,2/160,19/18670,0.011342204,0.025944481,0.012157478,IL1B/IL1A,2
BP,GO:0045980,negative regulation of nucleotide metabolic process,2/160,19/18670,0.011342204,0.025944481,0.012157478,PARP1/PPARA,2
BP,GO:0051546,keratinocyte migration,2/160,19/18670,0.011342204,0.025944481,0.012157478,MMP9/PPARD,2
BP,GO:0060252,positive regulation of glial cell proliferation,2/160,19/18670,0.011342204,0.025944481,0.012157478,IL1B/E2F1,2
BP,GO:0060716,labyrinthine layer blood vessel development,2/160,19/18670,0.011342204,0.025944481,0.012157478,AKT1/MAPK1,2
BP,GO:0070989,oxidative demethylation,2/160,19/18670,0.011342204,0.025944481,0.012157478,CYP3A4/CYP1A2,2
BP,GO:0072074,kidney mesenchyme development,2/160,19/18670,0.011342204,0.025944481,0.012157478,STAT1/MYC,2
BP,GO:0090201,negative regulation of release of cytochrome c from mitochondria,2/160,19/18670,0.011342204,0.025944481,0.012157478,AKT1/BCL2L1,2
BP,GO:2000696,regulation of epithelial cell differentiation involved in kidney development,2/160,19/18670,0.011342204,0.025944481,0.012157478,MMP9/STAT1,2
BP,GO:2001169,regulation of ATP biosynthetic process,2/160,19/18670,0.011342204,0.025944481,0.012157478,IL4/PARP1,2
BP,GO:0031647,regulation of protein stability,7/160,284/18670,0.011376345,0.026007715,0.012187109,BCL2/CDKN1A/CASP3/TP53/MAPK1/CHEK2/MDM2,7
BP,GO:0001823,mesonephros development,4/160,102/18670,0.011533339,0.02633654,0.012341195,BCL2/VEGFA/MYC/CAT,4
BP,GO:0002367,cytokine production involved in immune response,4/160,102/18670,0.011533339,0.02633654,0.012341195,MAPK14/IL4/HMOX1/IL1B,4
BP,GO:0002699,positive regulation of immune effector process,6/160,219/18670,0.011590296,0.026451513,0.012395071,NOS2/MAPK14/IL4/HMOX1/IL1B/IFNG,6
BP,GO:0002090,regulation of receptor internalization,3/160,55/18670,0.011700906,0.026688733,0.012506232,VEGFA/EGF/SELE,3
BP,GO:0060402,calcium ion transport into cytosol,5/160,158/18670,0.011711783,0.02669833,0.012510729,BCL2/BAX/CAV1/CXCL11/CXCL10,5
BP,GO:0018958,phenol-containing compound metabolic process,4/160,103/18670,0.011921143,0.02709843,0.012698214,BCL2/SLC6A3/MAOA/TYR,4
BP,GO:0034766,negative regulation of ion transmembrane transport,4/160,103/18670,0.011921143,0.02709843,0.012698214,AKT1/ADRA2A/MMP9/CAV1,4
BP,GO:0035601,protein deacylation,4/160,103/18670,0.011921143,0.02709843,0.012698214,TP53/VEGFA/IFNG/MAPK8,4
BP,GO:1902106,negative regulation of leukocyte differentiation,4/160,103/18670,0.011921143,0.02709843,0.012698214,IL4/ERBB2/MYC/IRF1,4
BP,GO:1905269,positive regulation of chromatin organization,4/160,103/18670,0.011921143,0.02709843,0.012698214,TP53/VEGFA/IL1B/CCNB1,4
BP,GO:0086002,cardiac muscle cell action potential involved in contraction,3/160,56/18670,0.012286849,0.027872161,0.013060781,SCN5A/CAV1/GJA1,3
BP,GO:0086065,cell communication involved in cardiac conduction,3/160,56/18670,0.012286849,0.027872161,0.013060781,SCN5A/CAV1/GJA1,3
BP,GO:1903078,positive regulation of protein localization to plasma membrane,3/160,56/18670,0.012286849,0.027872161,0.013060781,AKT1/EGFR/IFNG,3
BP,GO:0030203,glycosaminoglycan metabolic process,5/160,160/18670,0.012314666,0.027872161,0.013060781,AKT1/EGF/IL1B/HPSE/CD44,5
BP,GO:0032680,regulation of tumor necrosis factor production,5/160,160/18670,0.012314666,0.027872161,0.013060781,IL4/HSPB1/IFNG/GSTP1/APP,5
BP,GO:0032414,positive regulation of ion transmembrane transporter activity,4/160,104/18670,0.012317225,0.027872161,0.013060781,ADRB2/CCL2/HTR3A/IFNG,4
BP,GO:0098732,macromolecule deacylation,4/160,104/18670,0.012317225,0.027872161,0.013060781,TP53/VEGFA/IFNG/MAPK8,4
BP,GO:1901800,positive regulation of proteasomal protein catabolic process,4/160,104/18670,0.012317225,0.027872161,0.013060781,AKT1/CAV1/NFE2L2/MDM2,4
BP,GO:0043903,regulation of interspecies interactions between organisms,6/160,222/18670,0.012330039,0.027885393,0.013066982,BCL2/JUN/CXCL8/STAT1/CAV1/SLPI,6
BP,GO:0002827,positive regulation of T-helper 1 type immune response,2/160,20/18670,0.012532158,0.02816745,0.013199152,IL6R/IL1B,2
BP,GO:0006525,arginine metabolic process,2/160,20/18670,0.012532158,0.02816745,0.013199152,NOS2/NOS3,2
BP,GO:0019370,leukotriene biosynthetic process,2/160,20/18670,0.012532158,0.02816745,0.013199152,LTA4H/ALOX5,2
BP,GO:0030220,platelet formation,2/160,20/18670,0.012532158,0.02816745,0.013199152,CASP9/CASP3,2
BP,GO:0035458,cellular response to interferon-beta,2/160,20/18670,0.012532158,0.02816745,0.013199152,STAT1/IRF1,2
BP,GO:0045655,regulation of monocyte differentiation,2/160,20/18670,0.012532158,0.02816745,0.013199152,JUN/MYC,2
BP,GO:0060261,positive regulation of transcription initiation from RNA polymerase II promoter,2/160,20/18670,0.012532158,0.02816745,0.013199152,ESR1/TP53,2
BP,GO:0086014,atrial cardiac muscle cell action potential,2/160,20/18670,0.012532158,0.02816745,0.013199152,SCN5A/GJA1,2
BP,GO:0086026,atrial cardiac muscle cell to AV node cell signaling,2/160,20/18670,0.012532158,0.02816745,0.013199152,SCN5A/GJA1,2
BP,GO:0086066,atrial cardiac muscle cell to AV node cell communication,2/160,20/18670,0.012532158,0.02816745,0.013199152,SCN5A/GJA1,2
BP,GO:1903599,positive regulation of autophagy of mitochondrion,2/160,20/18670,0.012532158,0.02816745,0.013199152,HIF1A/HK2,2
BP,GO:0007009,plasma membrane organization,4/160,105/18670,0.012721645,0.028577298,0.013391205,AR/AKT1/SOD1/CAV1,4
BP,GO:0002066,columnar/cuboidal epithelial cell development,3/160,57/18670,0.012889368,0.028921604,0.013552546,CDKN1A/SOD1/HIF1A,3
BP,GO:0033344,cholesterol efflux,3/160,57/18670,0.012889368,0.028921604,0.013552546,PON1/EGF/NFKBIA,3
BP,GO:0003015,heart process,7/160,292/18670,0.013091738,0.029359231,0.013757616,SCN5A/ADRB1/SOD1/CAV1/GJA1/NOS3/MDM2,7
BP,GO:0030111,regulation of Wnt signaling pathway,8/160,363/18670,0.013148784,0.02947065,0.013809826,ESR1/MAPK14/EGFR/EGF/CAV1/COL1A1/APP/XIAP,8
BP,GO:0032640,tumor necrosis factor production,5/160,163/18670,0.013257967,0.029682126,0.013908923,IL4/HSPB1/IFNG/GSTP1/APP,5
BP,GO:1903555,regulation of tumor necrosis factor superfamily cytokine production,5/160,163/18670,0.013257967,0.029682126,0.013908923,IL4/HSPB1/IFNG/GSTP1/APP,5
BP,GO:0010676,positive regulation of cellular carbohydrate metabolic process,3/160,58/18670,0.01350853,0.0302093,0.014155955,AKT1/PPARA/IGF2,3
BP,GO:0098930,axonal transport,3/160,58/18670,0.01350853,0.0302093,0.014155955,SOD1/HIF1A/HSPB1,3
BP,GO:0002438,acute inflammatory response to antigenic stimulus,2/160,21/18670,0.01377413,0.030663619,0.014368847,OPRM1/ICAM1,2
BP,GO:0035357,peroxisome proliferator activated receptor signaling pathway,2/160,21/18670,0.01377413,0.030663619,0.014368847,PPARG/RXRA,2
BP,GO:0035743,"CD4-positive, alpha-beta T cell cytokine production",2/160,21/18670,0.01377413,0.030663619,0.014368847,IL4/IL1B,2
BP,GO:0036344,platelet morphogenesis,2/160,21/18670,0.01377413,0.030663619,0.014368847,CASP9/CASP3,2
BP,GO:0046716,muscle cell cellular homeostasis,2/160,21/18670,0.01377413,0.030663619,0.014368847,SOD1/HIF1A,2
BP,GO:0070584,mitochondrion morphogenesis,2/160,21/18670,0.01377413,0.030663619,0.014368847,BAX/BCL2L1,2
BP,GO:1901739,regulation of myoblast fusion,2/160,21/18670,0.01377413,0.030663619,0.014368847,MAPK14/CXCL10,2
BP,GO:2000810,regulation of bicellular tight junction assembly,2/160,21/18670,0.01377413,0.030663619,0.014368847,GJA1/IKBKB,2
BP,GO:0050768,negative regulation of neurogenesis,7/160,295/18670,0.013780627,0.030663619,0.014368847,TP53/SLC6A4/IL1B/SPP1/MDM2/APP/PPP3CA,7
BP,GO:0050954,sensory perception of mechanical stimulus,5/160,165/18670,0.013913259,0.030941541,0.01449908,CASP3/SOD1/ICAM1/BIRC5/COL1A1,5
BP,GO:0001658,branching involved in ureteric bud morphogenesis,3/160,59/18670,0.014144396,0.031351061,0.014690979,BCL2/VEGFA/MYC,3
BP,GO:0010518,positive regulation of phospholipase activity,3/160,59/18670,0.014144396,0.031351061,0.014690979,ESR1/EGFR/SELE,3
BP,GO:0031102,neuron projection regeneration,3/160,59/18670,0.014144396,0.031351061,0.014690979,BCL2/JUN/SPP1,3
BP,GO:0042130,negative regulation of T cell proliferation,3/160,59/18670,0.014144396,0.031351061,0.014690979,CASP3/ERBB2/IL2RA,3
BP,GO:0045843,negative regulation of striated muscle tissue development,3/160,59/18670,0.014144396,0.031351061,0.014690979,GJA1/PPARA/G6PD,3
BP,GO:0120178,steroid hormone biosynthetic process,3/160,59/18670,0.014144396,0.031351061,0.014690979,CYP3A4/HSD3B2/HSD3B1,3
BP,GO:0021761,limbic system development,4/160,109/18670,0.014423856,0.031935119,0.014964666,BAX/CASP3/HSD3B2/HSD3B1,4
BP,GO:0072009,nephron epithelium development,4/160,109/18670,0.014423856,0.031935119,0.014964666,BCL2/VEGFA/STAT1/MYC,4
BP,GO:1903320,regulation of protein modification by small protein conjugation or removal,6/160,231/18670,0.014747936,0.032634598,0.01529244,ADRB2/RELA/AKT1/HSPA5/CAV1/XIAP,6
BP,GO:0048635,negative regulation of muscle organ development,3/160,60/18670,0.01479702,0.032725122,0.015334859,GJA1/PPARA/G6PD,3
BP,GO:0071706,tumor necrosis factor superfamily cytokine production,5/160,168/18670,0.014936569,0.033012483,0.015469515,IL4/HSPB1/IFNG/GSTP1/APP,5
BP,GO:0000002,mitochondrial genome maintenance,2/160,22/18670,0.015067151,0.033012483,0.015469515,TP53/PARP1,2
BP,GO:0002052,positive regulation of neuroblast proliferation,2/160,22/18670,0.015067151,0.033012483,0.015469515,VEGFA/HIF1A,2
BP,GO:0006582,melanin metabolic process,2/160,22/18670,0.015067151,0.033012483,0.015469515,BCL2/TYR,2
BP,GO:0030878,thyroid gland development,2/160,22/18670,0.015067151,0.033012483,0.015469515,MAPK1/RAF1,2
BP,GO:0032727,positive regulation of interferon-alpha production,2/160,22/18670,0.015067151,0.033012483,0.015469515,STAT1/CHUK,2
BP,GO:0035584,calcium-mediated signaling using intracellular calcium source,2/160,22/18670,0.015067151,0.033012483,0.015469515,KDR/VCAM1,2
BP,GO:0042094,interleukin-2 biosynthetic process,2/160,22/18670,0.015067151,0.033012483,0.015469515,IL1B/IL1A,2
BP,GO:0044321,response to leptin,2/160,22/18670,0.015067151,0.033012483,0.015469515,CCND1/CCNA2,2
BP,GO:0045663,positive regulation of myoblast differentiation,2/160,22/18670,0.015067151,0.033012483,0.015469515,MAPK14/IGFBP3,2
BP,GO:0045723,positive regulation of fatty acid biosynthetic process,2/160,22/18670,0.015067151,0.033012483,0.015469515,PTGS2/IL1B,2
BP,GO:0051000,positive regulation of nitric-oxide synthase activity,2/160,22/18670,0.015067151,0.033012483,0.015469515,AKT1/HIF1A,2
BP,GO:0060575,intestinal epithelial cell differentiation,2/160,22/18670,0.015067151,0.033012483,0.015469515,CDKN1A/HIF1A,2
BP,GO:0071379,cellular response to prostaglandin stimulus,2/160,22/18670,0.015067151,0.033012483,0.015469515,PPARG/AKT1,2
BP,GO:1901685,glutathione derivative metabolic process,2/160,22/18670,0.015067151,0.033012483,0.015469515,GSTP1/GSTM1,2
BP,GO:1901687,glutathione derivative biosynthetic process,2/160,22/18670,0.015067151,0.033012483,0.015469515,GSTP1/GSTM1,2
BP,GO:1903589,positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis,2/160,22/18670,0.015067151,0.033012483,0.015469515,VEGFA/HMOX1,2
BP,GO:0022037,metencephalon development,4/160,111/18670,0.015326449,0.033562239,0.015727128,SCN5A/BCL2/TP53/HSPA5,4
BP,GO:0003170,heart valve development,3/160,61/18670,0.015466453,0.033794875,0.015836141,RB1/NOS3/MDM2,3
BP,GO:0007405,neuroblast proliferation,3/160,61/18670,0.015466453,0.033794875,0.015836141,TP53/VEGFA/HIF1A,3
BP,GO:0034113,heterotypic cell-cell adhesion,3/160,61/18670,0.015466453,0.033794875,0.015836141,IL1B/VCAM1/CD44,3
BP,GO:0042733,embryonic digit morphogenesis,3/160,61/18670,0.015466453,0.033794875,0.015836141,BAX/GJA1/ECE1,3
BP,GO:0048285,organelle fission,9/160,449/18670,0.015479183,0.033804239,0.015840529,KDR/EGF/RB1/IL1B/BIRC5/CCNB1/IL1A/CHEK2/IGF2,9
BP,GO:0006022,aminoglycan metabolic process,5/160,170/18670,0.015646106,0.034150144,0.016002618,AKT1/EGF/IL1B/HPSE/CD44,5
BP,GO:0014902,myotube differentiation,4/160,112/18670,0.0157908,0.034409674,0.016124233,MAPK14/BCL2/CXCL10/PPP3CA,4
BP,GO:0050868,negative regulation of T cell activation,4/160,112/18670,0.0157908,0.034409674,0.016124233,CASP3/ERBB2/IL2RA/IRF1,4
BP,GO:1903510,mucopolysaccharide metabolic process,4/160,112/18670,0.0157908,0.034409674,0.016124233,AKT1/EGF/IL1B/CD44,4
BP,GO:0010830,regulation of myotube differentiation,3/160,62/18670,0.016152739,0.035102832,0.016449044,MAPK14/BCL2/CXCL10,3
BP,GO:0032374,regulation of cholesterol transport,3/160,62/18670,0.016152739,0.035102832,0.016449044,PON1/EGF/NFKBIA,3
BP,GO:0048857,neural nucleus development,3/160,62/18670,0.016152739,0.035102832,0.016449044,BCL2/HSPA5/G6PD,3
BP,GO:0050433,regulation of catecholamine secretion,3/160,62/18670,0.016152739,0.035102832,0.016449044,ADRA2A/ADRA2C/ADRA2B,3
BP,GO:1901862,negative regulation of muscle tissue development,3/160,62/18670,0.016152739,0.035102832,0.016449044,GJA1/PPARA/G6PD,3
BP,GO:0002223,stimulatory C-type lectin receptor signaling pathway,4/160,113/18670,0.016263921,0.035325271,0.016553278,RELA/RAF1/CHUK/IKBKB,4
BP,GO:0032098,regulation of appetite,2/160,23/18670,0.016410268,0.035374423,0.01657631,OPRM1/PPARA,2
BP,GO:0032373,positive regulation of sterol transport,2/160,23/18670,0.016410268,0.035374423,0.01657631,PON1/NFKBIA,2
BP,GO:0032376,positive regulation of cholesterol transport,2/160,23/18670,0.016410268,0.035374423,0.01657631,PON1/NFKBIA,2
BP,GO:0034695,response to prostaglandin E,2/160,23/18670,0.016410268,0.035374423,0.01657631,PPARG/AKT1,2
BP,GO:0036037,"CD8-positive, alpha-beta T cell activation",2/160,23/18670,0.016410268,0.035374423,0.01657631,BCL2/IRF1,2
BP,GO:0051349,positive regulation of lyase activity,2/160,23/18670,0.016410268,0.035374423,0.01657631,NOS2/NOS3,2
BP,GO:0060055,angiogenesis involved in wound healing,2/160,23/18670,0.016410268,0.035374423,0.01657631,SERPINE1/HPSE,2
BP,GO:0061436,establishment of skin barrier,2/160,23/18670,0.016410268,0.035374423,0.01657631,CLDN4/MET,2
BP,GO:0071467,cellular response to pH,2/160,23/18670,0.016410268,0.035374423,0.01657631,GJA1/INSRR,2
BP,GO:0072215,regulation of metanephros development,2/160,23/18670,0.016410268,0.035374423,0.01657631,STAT1/MYC,2
BP,GO:1901032,negative regulation of response to reactive oxygen species,2/160,23/18670,0.016410268,0.035374423,0.01657631,NFE2L2/MET,2
BP,GO:1903206,negative regulation of hydrogen peroxide-induced cell death,2/160,23/18670,0.016410268,0.035374423,0.01657631,NFE2L2/MET,2
BP,GO:2000637,positive regulation of gene silencing by miRNA,2/160,23/18670,0.016410268,0.035374423,0.01657631,TP53/EGFR,2
BP,GO:2000726,negative regulation of cardiac muscle cell differentiation,2/160,23/18670,0.016410268,0.035374423,0.01657631,PPARA/G6PD,2
BP,GO:0016570,histone modification,9/160,454/18670,0.016516435,0.035584118,0.016674572,CDK2/TP53/PRKCA/CCNA2/VEGFA/IL1B/CCNB1/IGF2/MAPK8,9
BP,GO:0030282,bone mineralization,4/160,114/18670,0.016745859,0.036033674,0.016885233,PTGS2/ADRB2/HIF1A/GJA1,4
BP,GO:0042752,regulation of circadian rhythm,4/160,114/18670,0.016745859,0.036033674,0.016885233,PPARG/TP53/PPARA/MAPK8,4
BP,GO:0016525,negative regulation of angiogenesis,5/160,173/18670,0.016752103,0.036033674,0.016885233,PPARG/STAT1/SERPINE1/CXCL10/E2F2,5
BP,GO:0046888,negative regulation of hormone secretion,3/160,63/18670,0.016855919,0.036218058,0.016971634,ADRA2A/IL1B/PPP3CA,3
BP,GO:1904377,positive regulation of protein localization to cell periphery,3/160,63/18670,0.016855919,0.036218058,0.016971634,AKT1/EGFR/IFNG,3
BP,GO:0002695,negative regulation of leukocyte activation,5/160,175/18670,0.017517617,0.037599476,0.017618961,CASP3/ERBB2/HMOX1/IL2RA/IRF1,5
BP,GO:2000181,negative regulation of blood vessel morphogenesis,5/160,175/18670,0.017517617,0.037599476,0.017618961,PPARG/STAT1/SERPINE1/CXCL10/E2F2,5
BP,GO:0035773,insulin secretion involved in cellular response to glucose stimulus,3/160,64/18670,0.017576025,0.037664255,0.017649316,ADRA2A/RAF1/HIF1A,3
BP,GO:0048247,lymphocyte chemotaxis,3/160,64/18670,0.017576025,0.037664255,0.017649316,CCL2/CXCL11/CXCL10,3
BP,GO:0050432,catecholamine secretion,3/160,64/18670,0.017576025,0.037664255,0.017649316,ADRA2A/ADRA2C/ADRA2B,3
BP,GO:0002220,innate immune response activating cell surface receptor signaling pathway,4/160,116/18670,0.017736374,0.037885997,0.017753224,RELA/RAF1/CHUK/IKBKB,4
BP,GO:0001919,regulation of receptor recycling,2/160,24/18670,0.017802538,0.037885997,0.017753224,ACHE/ECE1,2
BP,GO:0007530,sex determination,2/160,24/18670,0.017802538,0.037885997,0.017753224,AR/INSRR,2
BP,GO:0010640,regulation of platelet-derived growth factor receptor signaling pathway,2/160,24/18670,0.017802538,0.037885997,0.017753224,F7/F3,2
BP,GO:0033081,regulation of T cell differentiation in thymus,2/160,24/18670,0.017802538,0.037885997,0.017753224,SOD1/ERBB2,2
BP,GO:0034505,tooth mineralization,2/160,24/18670,0.017802538,0.037885997,0.017753224,COL1A1/PPARA,2
BP,GO:0044346,fibroblast apoptotic process,2/160,24/18670,0.017802538,0.037885997,0.017753224,TP53/MYC,2
BP,GO:0050996,positive regulation of lipid catabolic process,2/160,24/18670,0.017802538,0.037885997,0.017753224,IL1B/PPARA,2
BP,GO:0060148,positive regulation of posttranscriptional gene silencing,2/160,24/18670,0.017802538,0.037885997,0.017753224,TP53/EGFR,2
BP,GO:0060343,trabecula formation,2/160,24/18670,0.017802538,0.037885997,0.017753224,MMP2/COL1A1,2
BP,GO:0071677,positive regulation of mononuclear cell migration,2/160,24/18670,0.017802538,0.037885997,0.017753224,SERPINE1/CXCL10,2
BP,GO:0086064,cell communication by electrical coupling involved in cardiac conduction,2/160,24/18670,0.017802538,0.037885997,0.017753224,CAV1/GJA1,2
BP,GO:2000178,negative regulation of neural precursor cell proliferation,2/160,24/18670,0.017802538,0.037885997,0.017753224,TP53/SLC6A4,2
BP,GO:0060401,cytosolic calcium ion transport,5/160,176/18670,0.017908928,0.038092156,0.017849829,BCL2/BAX/CAV1/CXCL11/CXCL10,5
BP,GO:0002758,innate immune response-activating signal transduction,4/160,117/18670,0.018245039,0.038765867,0.018165527,RELA/RAF1/CHUK/IKBKB,4
BP,GO:0031398,positive regulation of protein ubiquitination,4/160,117/18670,0.018245039,0.038765867,0.018165527,ADRB2/HSPA5/CAV1/XIAP,4
BP,GO:0043488,regulation of mRNA stability,5/160,177/18670,0.018305982,0.038828016,0.01819465,MAPK14/AKT1/PRKCA/HSPB1/E2F1,5
BP,GO:0014823,response to activity,3/160,65/18670,0.018313089,0.038828016,0.01819465,HIF1A/PPARD/CAT,3
BP,GO:0051148,negative regulation of muscle cell differentiation,3/160,65/18670,0.018313089,0.038828016,0.01819465,PPARA/CXCL10/G6PD,3
BP,GO:0060675,ureteric bud morphogenesis,3/160,65/18670,0.018313089,0.038828016,0.01819465,BCL2/VEGFA/MYC,3
BP,GO:0070613,regulation of protein processing,3/160,66/18670,0.019067133,0.040362631,0.018913764,SERPINE1/MDM2/XIAP,3
BP,GO:0072171,mesonephric tubule morphogenesis,3/160,66/18670,0.019067133,0.040362631,0.018913764,BCL2/VEGFA/MYC,3
BP,GO:1905207,regulation of cardiocyte differentiation,3/160,66/18670,0.019067133,0.040362631,0.018913764,EGFR/PPARA/G6PD,3
BP,GO:0008361,regulation of cell size,5/160,179/18670,0.019117449,0.04037204,0.018918173,AKT1/FN1/VEGFA/SPP1/CDK4,5
BP,GO:0030177,positive regulation of Wnt signaling pathway,5/160,179/18670,0.019117449,0.04037204,0.018918173,EGFR/EGF/CAV1/COL1A1/XIAP,5
BP,GO:0008211,glucocorticoid metabolic process,2/160,25/18670,0.019243031,0.04037204,0.018918173,HSD3B2/HSD3B1,2
BP,GO:0014829,vascular smooth muscle contraction,2/160,25/18670,0.019243031,0.04037204,0.018918173,CHRM3/ADRA2B,2
BP,GO:0032104,regulation of response to extracellular stimulus,2/160,25/18670,0.019243031,0.04037204,0.018918173,OPRM1/PPARA,2
BP,GO:0032107,regulation of response to nutrient levels,2/160,25/18670,0.019243031,0.04037204,0.018918173,OPRM1/PPARA,2
BP,GO:0042537,benzene-containing compound metabolic process,2/160,25/18670,0.019243031,0.04037204,0.018918173,GSTM1/UGT1A1,2
BP,GO:0044068,modulation by symbiont of host cellular process,2/160,25/18670,0.019243031,0.04037204,0.018918173,CASP8/BCL2L1,2
BP,GO:0045662,negative regulation of myoblast differentiation,2/160,25/18670,0.019243031,0.04037204,0.018918173,PPARD/CXCL10,2
BP,GO:0050901,leukocyte tethering or rolling,2/160,25/18670,0.019243031,0.04037204,0.018918173,SELE/VCAM1,2
BP,GO:0051156,glucose 6-phosphate metabolic process,2/160,25/18670,0.019243031,0.04037204,0.018918173,HK2/G6PD,2
BP,GO:0051894,positive regulation of focal adhesion assembly,2/160,25/18670,0.019243031,0.04037204,0.018918173,KDR/VEGFA,2
BP,GO:0061050,regulation of cell growth involved in cardiac muscle cell development,2/160,25/18670,0.019243031,0.04037204,0.018918173,PPARA/G6PD,2
BP,GO:0090025,regulation of monocyte chemotaxis,2/160,25/18670,0.019243031,0.04037204,0.018918173,SERPINE1/CXCL10,2
BP,GO:1900101,regulation of endoplasmic reticulum unfolded protein response,2/160,25/18670,0.019243031,0.04037204,0.018918173,BAX/HSPA5,2
BP,GO:1903306,negative regulation of regulated secretory pathway,2/160,25/18670,0.019243031,0.04037204,0.018918173,ADRA2A/HMOX1,2
BP,GO:2000353,positive regulation of endothelial cell apoptotic process,2/160,25/18670,0.019243031,0.04037204,0.018918173,CCL2/CD40LG,2
BP,GO:0051961,negative regulation of nervous system development,7/160,316/18670,0.019347988,0.040570978,0.019011395,TP53/SLC6A4/IL1B/SPP1/MDM2/APP/PPP3CA,7
BP,GO:0003014,renal system process,4/160,120/18670,0.019825179,0.041549838,0.019470085,BCL2/GJA1/CLDN4/ADCY2,4
BP,GO:0048747,muscle fiber development,3/160,67/18670,0.01983818,0.04155533,0.019472658,BCL2/VEGFA/PPP3CA,3
BP,GO:0002285,lymphocyte activation involved in immune response,5/160,181/18670,0.019952261,0.041772438,0.019574394,TP53/IL4/ICAM1/IFNG/CD40LG,5
BP,GO:0007204,positive regulation of cytosolic calcium ion concentration,7/160,319/18670,0.020255386,0.042362754,0.019851014,ESR1/BCL2/BAX/CAV1/GJA1/CXCL11/CXCL10,7
BP,GO:1990778,protein localization to cell periphery,7/160,319/18670,0.020255386,0.042362754,0.019851014,AR/AKT1/EGFR/BCL2L1/CAV1/IFNG/IKBKB,7
BP,GO:0046718,viral entry into host cell,4/160,121/18670,0.020370073,0.042580367,0.019952986,DPP4/EGFR/CAV1/ICAM1,4
BP,GO:0050891,multicellular organismal water homeostasis,3/160,68/18670,0.020626244,0.043042276,0.020169435,CLDN4/ADCY2/MET,3
BP,GO:1903317,regulation of protein maturation,3/160,68/18670,0.020626244,0.043042276,0.020169435,SERPINE1/MDM2/XIAP,3
BP,GO:0002360,T cell lineage commitment,2/160,26/18670,0.020730829,0.043042276,0.020169435,BCL2/TP53,2
BP,GO:0006309,apoptotic DNA fragmentation,2/160,26/18670,0.020730829,0.043042276,0.020169435,BAX/CASP3,2
BP,GO:0022011,myelination in peripheral nervous system,2/160,26/18670,0.020730829,0.043042276,0.020169435,AKT1/SOD1,2
BP,GO:0032292,peripheral nervous system axon ensheathment,2/160,26/18670,0.020730829,0.043042276,0.020169435,AKT1/SOD1,2
BP,GO:0033561,regulation of water loss via skin,2/160,26/18670,0.020730829,0.043042276,0.020169435,CLDN4/MET,2
BP,GO:0034114,regulation of heterotypic cell-cell adhesion,2/160,26/18670,0.020730829,0.043042276,0.020169435,IL1B/CD44,2
BP,GO:0043567,regulation of insulin-like growth factor receptor signaling pathway,2/160,26/18670,0.020730829,0.043042276,0.020169435,AR/IGFBP3,2
BP,GO:0060544,regulation of necroptotic process,2/160,26/18670,0.020730829,0.043042276,0.020169435,CASP8/CAV1,2
BP,GO:0060706,cell differentiation involved in embryonic placenta development,2/160,26/18670,0.020730829,0.043042276,0.020169435,AKT1/CASP8,2
BP,GO:0062098,regulation of programmed necrotic cell death,2/160,26/18670,0.020730829,0.043042276,0.020169435,CASP8/CAV1,2
BP,GO:0150117,positive regulation of cell-substrate junction organization,2/160,26/18670,0.020730829,0.043042276,0.020169435,KDR/VEGFA,2
BP,GO:0043487,regulation of RNA stability,5/160,183/18670,0.020810656,0.043185618,0.020236604,MAPK14/AKT1/PRKCA/HSPB1/E2F1,5
BP,GO:0019079,viral genome replication,4/160,122/18670,0.020924122,0.043376105,0.020325866,BCL2/CCL2/CXCL8/SLPI,4
BP,GO:0032434,regulation of proteasomal ubiquitin-dependent protein catabolic process,4/160,122/18670,0.020924122,0.043376105,0.020325866,AKT1/CAV1/NFE2L2/MDM2,4
BP,GO:0016569,covalent chromatin modification,9/160,474/18670,0.021180473,0.0438848,0.020564238,CDK2/TP53/PRKCA/CCNA2/VEGFA/IL1B/CCNB1/IGF2/MAPK8,9
BP,GO:0043409,negative regulation of MAPK cascade,5/160,184/18670,0.021248769,0.044003529,0.020619874,AKT1/CAV1/MYC/IL1B/GSTP1,5
BP,GO:0008016,regulation of heart contraction,6/160,251/18670,0.021263862,0.044012017,0.020623852,SCN5A/ADRB1/CAV1/GJA1/NOS3/MDM2,6
BP,GO:0071300,cellular response to retinoic acid,3/160,69/18670,0.021431335,0.044335729,0.020775542,PPARG/SLC6A4/COL1A1,3
BP,GO:0002062,chondrocyte differentiation,4/160,123/18670,0.02148736,0.044405732,0.020808345,MAPK14/RELA/POR/RUNX2,4
BP,GO:0051053,negative regulation of DNA metabolic process,4/160,123/18670,0.02148736,0.044405732,0.020808345,PPARG/TP53/GJA1/PARP1,4
BP,GO:0045216,cell-cell junction organization,5/160,185/18670,0.021692862,0.04480729,0.020996513,PRKCA/VEGFA/CAV1/GJA1/IKBKB,5
BP,GO:0022900,electron transport chain,5/160,186/18670,0.022142964,0.045589206,0.021362916,CYP1A2/POR/CCNB1/NCF1/NQO1,5
BP,GO:0010517,regulation of phospholipase activity,3/160,70/18670,0.022253461,0.045589206,0.021362916,ESR1/EGFR/SELE,3
BP,GO:0034121,regulation of toll-like receptor signaling pathway,3/160,70/18670,0.022253461,0.045589206,0.021362916,ESR1/CAV1/IRF1,3
BP,GO:0051966,"regulation of synaptic transmission, glutamatergic",3/160,70/18670,0.022253461,0.045589206,0.021362916,PTGS2/CCL2/EGFR,3
BP,GO:0060395,SMAD protein signal transduction,3/160,70/18670,0.022253461,0.045589206,0.021362916,JUN/FOS/PARP1,3
BP,GO:0072091,regulation of stem cell proliferation,3/160,70/18670,0.022253461,0.045589206,0.021362916,TP53/VEGFA/HIF1A,3
BP,GO:0002021,response to dietary excess,2/160,27/18670,0.022265026,0.045589206,0.021362916,ADRB2/ADRB1,2
BP,GO:0002825,regulation of T-helper 1 type immune response,2/160,27/18670,0.022265026,0.045589206,0.021362916,IL6R/IL1B,2
BP,GO:0009651,response to salt stress,2/160,27/18670,0.022265026,0.045589206,0.021362916,BAX/TP53,2
BP,GO:0048668,collateral sprouting,2/160,27/18670,0.022265026,0.045589206,0.021362916,SPP1/APP,2
BP,GO:0060307,regulation of ventricular cardiac muscle cell membrane repolarization,2/160,27/18670,0.022265026,0.045589206,0.021362916,SCN5A/GJA1,2
BP,GO:0072376,protein activation cascade,2/160,27/18670,0.022265026,0.045589206,0.021362916,F7/F3,2
BP,GO:0072378,"blood coagulation, fibrin clot formation",2/160,27/18670,0.022265026,0.045589206,0.021362916,F7/F3,2
BP,GO:1901623,regulation of lymphocyte chemotaxis,2/160,27/18670,0.022265026,0.045589206,0.021362916,CCL2/CXCL10,2
BP,GO:1905563,negative regulation of vascular endothelial cell proliferation,2/160,27/18670,0.022265026,0.045589206,0.021362916,PPARG/CCL2,2
BP,GO:2000191,regulation of fatty acid transport,2/160,27/18670,0.022265026,0.045589206,0.021362916,AKT1/IL1B,2
BP,GO:2001039,negative regulation of cellular response to drug,2/160,27/18670,0.022265026,0.045589206,0.021362916,NFE2L2/MET,2
BP,GO:1901343,negative regulation of vasculature development,5/160,187/18670,0.0225991,0.04624959,0.021672369,PPARG/STAT1/SERPINE1/CXCL10/E2F2,5
BP,GO:0030326,embryonic limb morphogenesis,4/160,125/18670,0.022641546,0.046289127,0.021690896,BAX/GJA1/RUNX2/ECE1,4
BP,GO:0035113,embryonic appendage morphogenesis,4/160,125/18670,0.022641546,0.046289127,0.021690896,BAX/GJA1/RUNX2/ECE1,4
BP,GO:0042531,positive regulation of tyrosine phosphorylation of STAT protein,3/160,71/18670,0.023092624,0.047187225,0.022111741,IL6R/IL4/IFNG,3
BP,GO:0090596,sensory organ morphogenesis,6/160,256/18670,0.023155319,0.047291194,0.022160461,BCL2/BAX/VEGFA/MAPK1/SOD1/HIF1A,6
BP,GO:0032479,regulation of type I interferon production,4/160,126/18670,0.02323256,0.047424751,0.022223045,RELA/STAT1/CHUK/IRF1,4
BP,GO:0045727,positive regulation of translation,4/160,127/18670,0.023832895,0.048256039,0.022612583,RXRA/MAPK1/ERBB2/CDK4,4
BP,GO:0001958,endochondral ossification,2/160,28/18670,0.023844728,0.048256039,0.022612583,COL1A1/RUNX2,2
BP,GO:0003180,aortic valve morphogenesis,2/160,28/18670,0.023844728,0.048256039,0.022612583,RB1/NOS3,2
BP,GO:0009065,glutamine family amino acid catabolic process,2/160,28/18670,0.023844728,0.048256039,0.022612583,NOS2/NOS3,2
BP,GO:0010818,T cell chemotaxis,2/160,28/18670,0.023844728,0.048256039,0.022612583,CXCL11/CXCL10,2
BP,GO:0032647,regulation of interferon-alpha production,2/160,28/18670,0.023844728,0.048256039,0.022612583,STAT1/CHUK,2
BP,GO:0033137,negative regulation of peptidyl-serine phosphorylation,2/160,28/18670,0.023844728,0.048256039,0.022612583,BAX/CAV1,2
BP,GO:0033688,regulation of osteoblast proliferation,2/160,28/18670,0.023844728,0.048256039,0.022612583,BCL2/HPSE,2
BP,GO:0035456,response to interferon-beta,2/160,28/18670,0.023844728,0.048256039,0.022612583,STAT1/IRF1,2
BP,GO:0036075,replacement ossification,2/160,28/18670,0.023844728,0.048256039,0.022612583,COL1A1/RUNX2,2
BP,GO:0045408,regulation of interleukin-6 biosynthetic process,2/160,28/18670,0.023844728,0.048256039,0.022612583,IL1B/APP,2
BP,GO:0051123,RNA polymerase II preinitiation complex assembly,2/160,28/18670,0.023844728,0.048256039,0.022612583,ESR1/TP53,2
BP,GO:0051984,positive regulation of chromosome segregation,2/160,28/18670,0.023844728,0.048256039,0.022612583,RB1/CCNB1,2
BP,GO:0060260,regulation of transcription initiation from RNA polymerase II promoter,2/160,28/18670,0.023844728,0.048256039,0.022612583,ESR1/TP53,2
BP,GO:0071168,protein localization to chromatin,2/160,28/18670,0.023844728,0.048256039,0.022612583,ESR1/RB1,2
BP,GO:1904994,regulation of leukocyte adhesion to vascular endothelial cell,2/160,28/18670,0.023844728,0.048256039,0.022612583,RELA/ICAM1,2
BP,GO:2000108,positive regulation of leukocyte apoptotic process,2/160,28/18670,0.023844728,0.048256039,0.022612583,BAX/TP53,2
BP,GO:0006305,DNA alkylation,3/160,72/18670,0.023948821,0.048320127,0.022642614,FOS/MYC/PARP1,3
BP,GO:0006306,DNA methylation,3/160,72/18670,0.023948821,0.048320127,0.022642614,FOS/MYC/PARP1,3
BP,GO:0032024,positive regulation of insulin secretion,3/160,72/18670,0.023948821,0.048320127,0.022642614,HIF1A/GJA1/PPARD,3
BP,GO:0060193,positive regulation of lipase activity,3/160,72/18670,0.023948821,0.048320127,0.022642614,ESR1/EGFR/SELE,3
BP,GO:0061035,regulation of cartilage development,3/160,72/18670,0.023948821,0.048320127,0.022642614,RELA/POR/RUNX2,3
BP,GO:2001259,positive regulation of cation channel activity,3/160,72/18670,0.023948821,0.048320127,0.022642614,ADRB2/CCL2/IFNG,3
BP,GO:0046942,carboxylic acid transport,7/160,331/18670,0.024182836,0.048767704,0.022852347,NOS2/PPARG/RXRA/AKT1/IL1B/PPARA/PPARD,7
BP,GO:0000280,nuclear division,8/160,407/18670,0.024263997,0.048906738,0.022917498,EGF/RB1/IL1B/BIRC5/CCNB1/IL1A/CHEK2/IGF2,8
BP,GO:0032606,type I interferon production,4/160,128/18670,0.024442581,0.049241899,0.023074553,RELA/STAT1/CHUK/IRF1,4
BP,GO:0098657,import into cell,5/160,191/18670,0.024484516,0.049301569,0.023102514,AKT1/SLC6A3/SLC6A4/IL10RA/IFNG,5
BP,GO:0072659,protein localization to plasma membrane,6/160,260/18670,0.024747713,0.049806482,0.023339114,AR/AKT1/EGFR/BCL2L1/IFNG/IKBKB,6
BP,GO:0032945,negative regulation of mononuclear cell proliferation,3/160,73/18670,0.024822047,0.049855822,0.023362235,CASP3/ERBB2/IL2RA,3
BP,GO:0050672,negative regulation of lymphocyte proliferation,3/160,73/18670,0.024822047,0.049855822,0.023362235,CASP3/ERBB2/IL2RA,3
BP,GO:0050688,regulation of defense response to virus,3/160,73/18670,0.024822047,0.049855822,0.023362235,STAT1/IL1B/IL2RA,3
BP,GO:0060350,endochondral bone morphogenesis,3/160,73/18670,0.024822047,0.049855822,0.023362235,POR/COL1A1/RUNX2,3
BP,GO:0015849,organic acid transport,7/160,333/18670,0.024884964,0.049957127,0.023409706,NOS2/PPARG/RXRA/AKT1/IL1B/PPARA/PPARD,7
BP,GO:0006164,purine nucleotide biosynthetic process,5/160,192/18670,0.024971214,0.050105147,0.023479068,NOS2/IL4/NOS3/PARP1/ADCY2,5
BP,GO:0007043,cell-cell junction assembly,4/160,129/18670,0.025061648,0.050236243,0.023540498,PRKCA/CAV1/GJA1/IKBKB,4
BP,GO:0044106,cellular amine metabolic process,4/160,129/18670,0.025061648,0.050236243,0.023540498,SLC6A3/MAOA/ODC1/NQO1,4
BP,GO:0051224,negative regulation of protein transport,5/160,193/18670,0.025464097,0.050747943,0.023780279,FN1/OPRM1/ADRA2A/IL1B/PPP3CA,5
BP,GO:0000083,regulation of transcription involved in G1/S transition of mitotic cell cycle,2/160,29/18670,0.025469053,0.050747943,0.023780279,RB1/E2F1,2
BP,GO:0005979,regulation of glycogen biosynthetic process,2/160,29/18670,0.025469053,0.050747943,0.023780279,AKT1/IGF2,2
BP,GO:0010644,cell communication by electrical coupling,2/160,29/18670,0.025469053,0.050747943,0.023780279,CAV1/GJA1,2
BP,GO:0010962,regulation of glucan biosynthetic process,2/160,29/18670,0.025469053,0.050747943,0.023780279,AKT1/IGF2,2
BP,GO:0014044,Schwann cell development,2/160,29/18670,0.025469053,0.050747943,0.023780279,AKT1/SOD1,2
BP,GO:0042226,interleukin-6 biosynthetic process,2/160,29/18670,0.025469053,0.050747943,0.023780279,IL1B/APP,2
BP,GO:0044030,regulation of DNA methylation,2/160,29/18670,0.025469053,0.050747943,0.023780279,MYC/PARP1,2
BP,GO:0044550,secondary metabolite biosynthetic process,2/160,29/18670,0.025469053,0.050747943,0.023780279,CYP1A2/TYR,2
BP,GO:0060142,regulation of syncytium formation by plasma membrane fusion,2/160,29/18670,0.025469053,0.050747943,0.023780279,MAPK14/CXCL10,2
BP,GO:0070102,interleukin-6-mediated signaling pathway,2/160,29/18670,0.025469053,0.050747943,0.023780279,IL6R/STAT1,2
BP,GO:1900027,regulation of ruffle assembly,2/160,29/18670,0.025469053,0.050747943,0.023780279,CAV1/ICAM1,2
BP,GO:0030104,water homeostasis,3/160,74/18670,0.025712291,0.051105413,0.023947788,CLDN4/ADCY2/MET,3
BP,GO:0072078,nephron tubule morphogenesis,3/160,74/18670,0.025712291,0.051105413,0.023947788,BCL2/VEGFA/MYC,3
BP,GO:0086001,cardiac muscle cell action potential,3/160,74/18670,0.025712291,0.051105413,0.023947788,SCN5A/CAV1/GJA1,3
BP,GO:0086003,cardiac muscle cell contraction,3/160,74/18670,0.025712291,0.051105413,0.023947788,SCN5A/CAV1/GJA1,3
BP,GO:1901616,organic hydroxy compound catabolic process,3/160,74/18670,0.025712291,0.051105413,0.023947788,SLC6A3/MAOA/SULT1E1,3
BP,GO:0001960,negative regulation of cytokine-mediated signaling pathway,3/160,75/18670,0.026619539,0.052803774,0.024743633,PPARG/CAV1/GSTP1,3
BP,GO:0002479,"antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent",3/160,75/18670,0.026619539,0.052803774,0.024743633,NCF1/CHUK/IKBKB,3
BP,GO:0006695,cholesterol biosynthetic process,3/160,75/18670,0.026619539,0.052803774,0.024743633,POR/SOD1/G6PD,3
BP,GO:0033143,regulation of intracellular steroid hormone receptor signaling pathway,3/160,75/18670,0.026619539,0.052803774,0.024743633,ESR1/AR/PARP1,3
BP,GO:0010389,regulation of G2/M transition of mitotic cell cycle,5/160,196/18670,0.026980092,0.053492476,0.025066356,CDK2/CCND1/CCNB1/CDK4/APP,5
BP,GO:0015711,organic anion transport,9/160,495/18670,0.027031092,0.053538655,0.025087995,NOS2/PPARG/RXRA/AKT1/CA2/GJA1/IL1B/PPARA/PPARD,9
BP,GO:0032607,interferon-alpha production,2/160,30/18670,0.02713713,0.053538655,0.025087995,STAT1/CHUK,2
BP,GO:0032743,positive regulation of interleukin-2 production,2/160,30/18670,0.02713713,0.053538655,0.025087995,IL1B/IL1A,2
BP,GO:0043171,peptide catabolic process,2/160,30/18670,0.02713713,0.053538655,0.025087995,LTA4H/ECE1,2
BP,GO:0045879,negative regulation of smoothened signaling pathway,2/160,30/18670,0.02713713,0.053538655,0.025087995,RB1/RUNX2,2
BP,GO:0045939,negative regulation of steroid metabolic process,2/160,30/18670,0.02713713,0.053538655,0.025087995,SOD1/UGT1A1,2
BP,GO:0070168,negative regulation of biomineral tissue development,2/160,30/18670,0.02713713,0.053538655,0.025087995,HIF1A/NOS3,2
BP,GO:0110150,negative regulation of biomineralization,2/160,30/18670,0.02713713,0.053538655,0.025087995,HIF1A/NOS3,2
BP,GO:1903205,regulation of hydrogen peroxide-induced cell death,2/160,30/18670,0.02713713,0.053538655,0.025087995,NFE2L2/MET,2
BP,GO:1904292,regulation of ERAD pathway,2/160,30/18670,0.02713713,0.053538655,0.025087995,CAV1/NFE2L2,2
BP,GO:1904950,negative regulation of establishment of protein localization,5/160,197/18670,0.027497947,0.054127504,0.025363928,FN1/OPRM1/ADRA2A/IL1B/PPP3CA,5
BP,GO:0000422,autophagy of mitochondrion,3/160,76/18670,0.027543774,0.054127504,0.025363928,TP53/HIF1A/HK2,3
BP,GO:0007492,endoderm development,3/160,76/18670,0.027543774,0.054127504,0.025363928,FN1/MMP2/MMP9,3
BP,GO:0008589,regulation of smoothened signaling pathway,3/160,76/18670,0.027543774,0.054127504,0.025363928,RB1/POR/RUNX2,3
BP,GO:0030500,regulation of bone mineralization,3/160,76/18670,0.027543774,0.054127504,0.025363928,ADRB2/HIF1A/GJA1,3
BP,GO:0060411,cardiac septum morphogenesis,3/160,76/18670,0.027543774,0.054127504,0.025363928,TP53/NOS3/MDM2,3
BP,GO:0061726,mitochondrion disassembly,3/160,76/18670,0.027543774,0.054127504,0.025363928,TP53/HIF1A/HK2,3
BP,GO:1902653,secondary alcohol biosynthetic process,3/160,76/18670,0.027543774,0.054127504,0.025363928,POR/SOD1/G6PD,3
BP,GO:0007626,locomotory behavior,5/160,198/18670,0.0280221,0.055040463,0.025791737,DPP4/SLC6A3/OPRM1/SOD1/APP,5
BP,GO:0043588,skin development,8/160,419/18670,0.028187498,0.055338183,0.025931247,RELA/BCL2/CASP3/EGFR/COL1A1/CLDN4/HPSE/MET,8
BP,GO:0007272,ensheathment of neurons,4/160,134/18670,0.028298582,0.055501825,0.026007929,AKT1/SOD1/ERBB2/PPARD,4
BP,GO:0008366,axon ensheathment,4/160,134/18670,0.028298582,0.055501825,0.026007929,AKT1/SOD1/ERBB2/PPARD,4
BP,GO:0016575,histone deacetylation,3/160,77/18670,0.028484973,0.055840032,0.026166411,TP53/VEGFA/MAPK8,3
BP,GO:0061013,regulation of mRNA catabolic process,5/160,199/18670,0.02855257,0.055945149,0.026215669,MAPK14/AKT1/PRKCA/HSPB1/E2F1,5
BP,GO:0001963,"synaptic transmission, dopaminergic",2/160,31/18670,0.0288481,0.056276289,0.02637084,PTGS2/SLC6A4,2
BP,GO:0002675,positive regulation of acute inflammatory response,2/160,31/18670,0.0288481,0.056276289,0.02637084,PTGS2/IL1B,2
BP,GO:0006691,leukotriene metabolic process,2/160,31/18670,0.0288481,0.056276289,0.02637084,LTA4H/ALOX5,2
BP,GO:0007202,activation of phospholipase C activity,2/160,31/18670,0.0288481,0.056276289,0.02637084,EGFR/SELE,2
BP,GO:0033687,osteoblast proliferation,2/160,31/18670,0.0288481,0.056276289,0.02637084,BCL2/HPSE,2
BP,GO:0034694,response to prostaglandin,2/160,31/18670,0.0288481,0.056276289,0.02637084,PPARG/AKT1,2
BP,GO:0042168,heme metabolic process,2/160,31/18670,0.0288481,0.056276289,0.02637084,HMOX1/UGT1A1,2
BP,GO:0099625,ventricular cardiac muscle cell membrane repolarization,2/160,31/18670,0.0288481,0.056276289,0.02637084,SCN5A/GJA1,2
BP,GO:2000406,positive regulation of T cell migration,2/160,31/18670,0.0288481,0.056276289,0.02637084,CXCL10/APP,2
BP,GO:1903322,positive regulation of protein modification by small protein conjugation or removal,4/160,135/18670,0.028974452,0.056495243,0.02647344,ADRB2/HSPA5/CAV1/XIAP,4
BP,GO:0000271,polysaccharide biosynthetic process,3/160,78/18670,0.029443111,0.057213967,0.026810232,AKT1/EGF/IGF2,3
BP,GO:0008306,associative learning,3/160,78/18670,0.029443111,0.057213967,0.026810232,FOS/HIF1A/APP,3
BP,GO:0030433,ubiquitin-dependent ERAD pathway,3/160,78/18670,0.029443111,0.057213967,0.026810232,HSPA5/CAV1/NFE2L2,3
BP,GO:0032413,negative regulation of ion transmembrane transporter activity,3/160,78/18670,0.029443111,0.057213967,0.026810232,ADRA2A/MMP9/CAV1,3
BP,GO:0043407,negative regulation of MAP kinase activity,3/160,78/18670,0.029443111,0.057213967,0.026810232,CAV1/IL1B/GSTP1,3
BP,GO:0061333,renal tubule morphogenesis,3/160,78/18670,0.029443111,0.057213967,0.026810232,BCL2/VEGFA/MYC,3
BP,GO:0090398,cellular senescence,3/160,78/18670,0.029443111,0.057213967,0.026810232,MAPK14/CDKN1A/TP53,3
BP,GO:0001570,vasculogenesis,3/160,79/18670,0.030418159,0.059022729,0.02765781,KDR/VEGFA/CAV1,3
BP,GO:0003151,outflow tract morphogenesis,3/160,79/18670,0.030418159,0.059022729,0.02765781,JUN/VEGFA/HIF1A,3
BP,GO:0042590,antigen processing and presentation of exogenous peptide antigen via MHC class I,3/160,79/18670,0.030418159,0.059022729,0.02765781,NCF1/CHUK/IKBKB,3
BP,GO:0003176,aortic valve development,2/160,32/18670,0.030601116,0.059062809,0.027676591,RB1/NOS3,2
BP,GO:0008608,attachment of spindle microtubules to kinetochore,2/160,32/18670,0.030601116,0.059062809,0.027676591,RB1/CCNB1,2
BP,GO:0042744,hydrogen peroxide catabolic process,2/160,32/18670,0.030601116,0.059062809,0.027676591,MPO/CAT,2
BP,GO:0048741,skeletal muscle fiber development,2/160,32/18670,0.030601116,0.059062809,0.027676591,BCL2/PPP3CA,2
BP,GO:0055094,response to lipoprotein particle,2/160,32/18670,0.030601116,0.059062809,0.027676591,PPARG/AKT1,2
BP,GO:0060325,face morphogenesis,2/160,32/18670,0.030601116,0.059062809,0.027676591,MMP2/COL1A1,2
BP,GO:0060674,placenta blood vessel development,2/160,32/18670,0.030601116,0.059062809,0.027676591,AKT1/MAPK1,2
BP,GO:0071353,cellular response to interleukin-4,2/160,32/18670,0.030601116,0.059062809,0.027676591,HSPA5/CDK4,2
BP,GO:0086019,cell-cell signaling involved in cardiac conduction,2/160,32/18670,0.030601116,0.059062809,0.027676591,SCN5A/GJA1,2
BP,GO:0099623,regulation of cardiac muscle cell membrane repolarization,2/160,32/18670,0.030601116,0.059062809,0.027676591,SCN5A/GJA1,2
BP,GO:1901976,regulation of cell cycle checkpoint,2/160,32/18670,0.030601116,0.059062809,0.027676591,CCNB1/CHEK2,2
BP,GO:0046631,alpha-beta T cell activation,4/160,138/18670,0.031059393,0.059918433,0.028077533,BCL2/IL6R/IFNG/IRF1,4
BP,GO:0031396,regulation of protein ubiquitination,5/160,204/18670,0.031300393,0.060354274,0.028281767,ADRB2/AKT1/HSPA5/CAV1/XIAP,5
BP,GO:0007586,digestion,4/160,139/18670,0.03177354,0.061237111,0.02869546,PRSS1/CHRM3/CHRM1/ADRA2A,4
BP,GO:0051260,protein homooligomerization,7/160,351/18670,0.031842958,0.061303381,0.028726514,RXRA/BAX/TP53/SLC6A4/HMOX1/CAV1/CAT,7
BP,GO:0002703,regulation of leukocyte mediated immunity,5/160,205/18670,0.031869182,0.061303381,0.028726514,NOS2/IL4/HMOX1/ICAM1/IL1B,5
BP,GO:0015893,drug transport,5/160,205/18670,0.031869182,0.061303381,0.028726514,SLC6A3/CA2/MYC/GJA1/NR1I2,5
BP,GO:0072522,purine-containing compound biosynthetic process,5/160,205/18670,0.031869182,0.061303381,0.028726514,NOS2/IL4/NOS3/PARP1/ADCY2,5
BP,GO:0006471,protein ADP-ribosylation,2/160,33/18670,0.03239534,0.062003187,0.029054441,IFNG/PARP1,2
BP,GO:0045736,negative regulation of cyclin-dependent protein serine/threonine kinase activity,2/160,33/18670,0.03239534,0.062003187,0.029054441,CDKN1A/CASP3,2
BP,GO:0048011,neurotrophin TRK receptor signaling pathway,2/160,33/18670,0.03239534,0.062003187,0.029054441,CASP3/RAF1,2
BP,GO:0070232,regulation of T cell apoptotic process,2/160,33/18670,0.03239534,0.062003187,0.029054441,TP53/HIF1A,2
BP,GO:0014032,neural crest cell development,3/160,81/18670,0.032418853,0.062003187,0.029054441,FN1/MAPK1/HIF1A,3
BP,GO:0016126,sterol biosynthetic process,3/160,81/18670,0.032418853,0.062003187,0.029054441,POR/SOD1/G6PD,3
BP,GO:0021766,hippocampus development,3/160,81/18670,0.032418853,0.062003187,0.029054441,CASP3/HSD3B2/HSD3B1,3
BP,GO:0030512,negative regulation of transforming growth factor beta receptor signaling pathway,3/160,81/18670,0.032418853,0.062003187,0.029054441,TP53/HSPA5/CAV1,3
BP,GO:0032204,regulation of telomere maintenance,3/160,81/18670,0.032418853,0.062003187,0.029054441,MAPK1/MYC/PARP1,3
BP,GO:0033238,regulation of cellular amine metabolic process,3/160,81/18670,0.032418853,0.062003187,0.029054441,SLC6A3/ODC1/NQO1,3
BP,GO:0048041,focal adhesion assembly,3/160,81/18670,0.032418853,0.062003187,0.029054441,BCL2/KDR/VEGFA,3
BP,GO:0060761,negative regulation of response to cytokine stimulus,3/160,81/18670,0.032418853,0.062003187,0.029054441,PPARG/CAV1/GSTP1,3
BP,GO:0032637,interleukin-8 production,3/160,82/18670,0.033444424,0.063903595,0.029944964,NOS2/IL1B/SERPINE1,3
BP,GO:0051279,regulation of release of sequestered calcium ion into cytosol,3/160,82/18670,0.033444424,0.063903595,0.029944964,BAX/CXCL11/CXCL10,3
BP,GO:0016051,carbohydrate biosynthetic process,5/160,208/18670,0.033614314,0.064166953,0.030068372,AKT1/EGF/PPARA/IGF2/G6PD,5
BP,GO:0050792,regulation of viral process,5/160,208/18670,0.033614314,0.064166953,0.030068372,BCL2/JUN/CXCL8/STAT1/SLPI,5
BP,GO:0002218,activation of innate immune response,4/160,142/18670,0.033973684,0.064822049,0.030375348,RELA/RAF1/CHUK/IKBKB,4
BP,GO:0000737,"DNA catabolic process, endonucleolytic",2/160,34/18670,0.034229947,0.065032026,0.030473742,BAX/CASP3,2
BP,GO:0003382,epithelial cell morphogenesis,2/160,34/18670,0.034229947,0.065032026,0.030473742,AR/MET,2
BP,GO:0010765,positive regulation of sodium ion transport,2/160,34/18670,0.034229947,0.065032026,0.030473742,SCN5A/AKT1,2
BP,GO:0036474,cell death in response to hydrogen peroxide,2/160,34/18670,0.034229947,0.065032026,0.030473742,NFE2L2/MET,2
BP,GO:0045920,negative regulation of exocytosis,2/160,34/18670,0.034229947,0.065032026,0.030473742,ADRA2A/HMOX1,2
BP,GO:0070670,response to interleukin-4,2/160,34/18670,0.034229947,0.065032026,0.030473742,HSPA5/CDK4,2
BP,GO:0071402,cellular response to lipoprotein particle stimulus,2/160,34/18670,0.034229947,0.065032026,0.030473742,PPARG/AKT1,2
BP,GO:0098664,G protein-coupled serotonin receptor signaling pathway,2/160,34/18670,0.034229947,0.065032026,0.030473742,CHRM3/CHRM1,2
BP,GO:1904030,negative regulation of cyclin-dependent protein kinase activity,2/160,34/18670,0.034229947,0.065032026,0.030473742,CDKN1A/CASP3,2
BP,GO:0051480,regulation of cytosolic calcium ion concentration,7/160,357/18670,0.034425961,0.065373397,0.030633707,ESR1/BCL2/BAX/CAV1/GJA1/CXCL11/CXCL10,7
BP,GO:0045582,positive regulation of T cell differentiation,3/160,83/18670,0.034486756,0.065395776,0.030644194,IL4/IL2RA/IFNG,3
BP,GO:1903845,negative regulation of cellular response to transforming growth factor beta stimulus,3/160,83/18670,0.034486756,0.065395776,0.030644194,TP53/HSPA5/CAV1,3
BP,GO:2000106,regulation of leukocyte apoptotic process,3/160,83/18670,0.034486756,0.065395776,0.030644194,BAX/TP53/HIF1A,3
BP,GO:0044262,cellular carbohydrate metabolic process,6/160,282/18670,0.034817828,0.065992314,0.030923729,AKT1/TP53/PPARA/IGFBP3/IGF2/HK2,6
BP,GO:0002718,regulation of cytokine production involved in immune response,3/160,84/18670,0.035545802,0.067308347,0.031540417,MAPK14/HMOX1/IL1B,3
BP,GO:0050886,endocrine process,3/160,84/18670,0.035545802,0.067308347,0.031540417,IL1B/NOS3/ECE1,3
BP,GO:0001881,receptor recycling,2/160,35/18670,0.036104123,0.068107825,0.031915049,ACHE/ECE1,2
BP,GO:0003203,endocardial cushion morphogenesis,2/160,35/18670,0.036104123,0.068107825,0.031915049,NOS3/MDM2,2
BP,GO:0014904,myotube cell development,2/160,35/18670,0.036104123,0.068107825,0.031915049,BCL2/PPP3CA,2
BP,GO:0030262,apoptotic nuclear changes,2/160,35/18670,0.036104123,0.068107825,0.031915049,BAX/CASP3,2
BP,GO:0070873,regulation of glycogen metabolic process,2/160,35/18670,0.036104123,0.068107825,0.031915049,AKT1/IGF2,2
BP,GO:0110111,negative regulation of animal organ morphogenesis,2/160,35/18670,0.036104123,0.068107825,0.031915049,BCL2/STAT1,2
BP,GO:1905332,positive regulation of morphogenesis of an epithelium,2/160,35/18670,0.036104123,0.068107825,0.031915049,AR/VEGFA,2
BP,GO:2001024,negative regulation of response to drug,2/160,35/18670,0.036104123,0.068107825,0.031915049,NFE2L2/MET,2
BP,GO:0048864,stem cell development,3/160,85/18670,0.036621515,0.069051306,0.032357161,FN1/MAPK1/HIF1A,3
BP,GO:0060828,regulation of canonical Wnt signaling pathway,6/160,286/18670,0.036895506,0.069535175,0.032583899,MAPK14/EGFR/EGF/CAV1/COL1A1/XIAP,6
BP,GO:0051250,negative regulation of lymphocyte activation,4/160,146/18670,0.037042277,0.069778934,0.032698124,CASP3/ERBB2/IL2RA/IRF1,4
BP,GO:1903050,regulation of proteolysis involved in cellular protein catabolic process,5/160,214/18670,0.03728041,0.070194488,0.032892851,AKT1/EGF/CAV1/NFE2L2/MDM2,5
BP,GO:0032760,positive regulation of tumor necrosis factor production,3/160,86/18670,0.037713842,0.070977202,0.033259627,HSPB1/IFNG/APP,3
BP,GO:0006007,glucose catabolic process,2/160,36/18670,0.038017064,0.071346604,0.033432728,TP53/HK2,2
BP,GO:0033762,response to glucagon,2/160,36/18670,0.038017064,0.071346604,0.033432728,CCNA2/ADCY2,2
BP,GO:0046627,negative regulation of insulin receptor signaling pathway,2/160,36/18670,0.038017064,0.071346604,0.033432728,RELA/IL1B,2
BP,GO:0051973,positive regulation of telomerase activity,2/160,36/18670,0.038017064,0.071346604,0.033432728,MAPK1/MYC,2
BP,GO:0071634,regulation of transforming growth factor beta production,2/160,36/18670,0.038017064,0.071346604,0.033432728,PTGS2/HIF1A,2
BP,GO:0097242,amyloid-beta clearance,2/160,36/18670,0.038017064,0.071346604,0.033432728,IL4/IFNG,2
BP,GO:0035107,appendage morphogenesis,4/160,148/18670,0.038634608,0.072437629,0.033943977,BAX/GJA1/RUNX2/ECE1,4
BP,GO:0035108,limb morphogenesis,4/160,148/18670,0.038634608,0.072437629,0.033943977,BAX/GJA1/RUNX2/ECE1,4
BP,GO:0006112,energy reserve metabolic process,3/160,87/18670,0.038822729,0.072756266,0.034093289,AKT1/MYC/IGF2,3
BP,GO:0060348,bone development,5/160,217/18670,0.03920212,0.07343289,0.034410353,TP53/POR/GJA1/COL1A1/RUNX2,5
BP,GO:0048592,eye morphogenesis,4/160,149/18670,0.039445302,0.073819329,0.034591436,BCL2/BAX/VEGFA/HIF1A,4
BP,GO:0060041,retina development in camera-type eye,4/160,149/18670,0.039445302,0.073819329,0.034591436,BAX/ACHE/HIF1A/CYP1B1,4
BP,GO:0043506,regulation of JUN kinase activity,3/160,88/18670,0.039948118,0.074276607,0.034805715,GSTP1/CD40LG/MAP2K4,3
BP,GO:0050829,defense response to Gram-negative bacterium,3/160,88/18670,0.039948118,0.074276607,0.034805715,NOS2/IL6R/SERPINE1,3
BP,GO:1903321,negative regulation of protein modification by small protein conjugation or removal,3/160,88/18670,0.039948118,0.074276607,0.034805715,RELA/AKT1/CAV1,3
BP,GO:1903557,positive regulation of tumor necrosis factor superfamily cytokine production,3/160,88/18670,0.039948118,0.074276607,0.034805715,HSPB1/IFNG/APP,3
BP,GO:0006921,cellular component disassembly involved in execution phase of apoptosis,2/160,37/18670,0.039967977,0.074276607,0.034805715,BAX/CASP3,2
BP,GO:0010614,negative regulation of cardiac muscle hypertrophy,2/160,37/18670,0.039967977,0.074276607,0.034805715,PPARA/G6PD,2
BP,GO:0045730,respiratory burst,2/160,37/18670,0.039967977,0.074276607,0.034805715,MPO/NCF1,2
BP,GO:0045777,positive regulation of blood pressure,2/160,37/18670,0.039967977,0.074276607,0.034805715,ADRB1/ADRA2B,2
BP,GO:0050691,regulation of defense response to virus by host,2/160,37/18670,0.039967977,0.074276607,0.034805715,STAT1/IL1B,2
BP,GO:0051193,regulation of cofactor metabolic process,2/160,37/18670,0.039967977,0.074276607,0.034805715,MMP3/NFE2L2,2
BP,GO:0052372,modulation by symbiont of entry into host,2/160,37/18670,0.039967977,0.074276607,0.034805715,CXCL8/CAV1,2
BP,GO:0060323,head morphogenesis,2/160,37/18670,0.039967977,0.074276607,0.034805715,MMP2/COL1A1,2
BP,GO:0071542,dopaminergic neuron differentiation,2/160,37/18670,0.039967977,0.074276607,0.034805715,VEGFA/HIF1A,2
BP,GO:1905314,semi-lunar valve development,2/160,37/18670,0.039967977,0.074276607,0.034805715,RB1/NOS3,2
BP,GO:2000403,positive regulation of lymphocyte migration,2/160,37/18670,0.039967977,0.074276607,0.034805715,CXCL10/APP,2
BP,GO:0006909,phagocytosis,7/160,369/18670,0.040002598,0.07430645,0.034819699,PPARG/CCL2/MAPK1/SOD1/IL1B/IFNG/MET,7
BP,GO:0043583,ear development,5/160,219/18670,0.040516317,0.075225796,0.035250501,BCL2/CCNA2/MAPK1/SOD1/ECE1,5
BP,GO:0045666,positive regulation of neuron differentiation,7/160,371/18670,0.040986223,0.076062981,0.035642803,BCL2/FN1/ADRA2C/ADRA2B/VEGFA/HSPA5/NFE2L2,7
BP,GO:0032410,negative regulation of transporter activity,3/160,89/18670,0.04108995,0.076220144,0.035716449,ADRA2A/MMP9/CAV1,3
BP,GO:0010831,positive regulation of myotube differentiation,2/160,38/18670,0.041956079,0.077432081,0.036284358,MAPK14/BCL2,2
BP,GO:0010939,regulation of necrotic cell death,2/160,38/18670,0.041956079,0.077432081,0.036284358,CASP8/CAV1,2
BP,GO:0046329,negative regulation of JNK cascade,2/160,38/18670,0.041956079,0.077432081,0.036284358,AKT1/GSTP1,2
BP,GO:0046676,negative regulation of insulin secretion,2/160,38/18670,0.041956079,0.077432081,0.036284358,ADRA2A/PPP3CA,2
BP,GO:0048246,macrophage chemotaxis,2/160,38/18670,0.041956079,0.077432081,0.036284358,MAPK14/CCL2,2
BP,GO:0060416,response to growth hormone,2/160,38/18670,0.041956079,0.077432081,0.036284358,AKT1/F7,2
BP,GO:0071604,transforming growth factor beta production,2/160,38/18670,0.041956079,0.077432081,0.036284358,PTGS2/HIF1A,2
BP,GO:0086005,ventricular cardiac muscle cell action potential,2/160,38/18670,0.041956079,0.077432081,0.036284358,SCN5A/CAV1,2
BP,GO:0086091,regulation of heart rate by cardiac conduction,2/160,38/18670,0.041956079,0.077432081,0.036284358,SCN5A/CAV1,2
BP,GO:1900077,negative regulation of cellular response to insulin stimulus,2/160,38/18670,0.041956079,0.077432081,0.036284358,RELA/IL1B,2
BP,GO:1904037,positive regulation of epithelial cell apoptotic process,2/160,38/18670,0.041956079,0.077432081,0.036284358,CCL2/CD40LG,2
BP,GO:0001656,metanephros development,3/160,90/18670,0.042248161,0.077827607,0.036469699,BCL2/STAT1/MYC,3
BP,GO:0014033,neural crest cell differentiation,3/160,90/18670,0.042248161,0.077827607,0.036469699,FN1/MAPK1/HIF1A,3
BP,GO:0030641,regulation of cellular pH,3/160,90/18670,0.042248161,0.077827607,0.036469699,BCL2/CA2/MAPK1,3
BP,GO:0045778,positive regulation of ossification,3/160,90/18670,0.042248161,0.077827607,0.036469699,ADRB2/IL6R/RUNX2,3
BP,GO:0045638,negative regulation of myeloid cell differentiation,3/160,91/18670,0.043422686,0.079917707,0.037449112,IL4/NFKBIA/MYC,3
BP,GO:1904063,negative regulation of cation transmembrane transport,3/160,91/18670,0.043422686,0.079917707,0.037449112,ADRA2A/MMP9/CAV1,3
BP,GO:0006874,cellular calcium ion homeostasis,8/160,458/18670,0.043930073,0.080537209,0.037739408,ESR1/BCL2/BAX/CAV1/GJA1/CXCL11/CXCL10/APP,8
BP,GO:0002251,organ or tissue specific immune response,2/160,39/18670,0.043980599,0.080537209,0.037739408,NOS2/IL6R,2
BP,GO:0007257,activation of JUN kinase activity,2/160,39/18670,0.043980599,0.080537209,0.037739408,CD40LG/MAP2K4,2
BP,GO:0008207,C21-steroid hormone metabolic process,2/160,39/18670,0.043980599,0.080537209,0.037739408,HSD3B2/HSD3B1,2
BP,GO:0014741,negative regulation of muscle hypertrophy,2/160,39/18670,0.043980599,0.080537209,0.037739408,PPARA/G6PD,2
BP,GO:0038179,neurotrophin signaling pathway,2/160,39/18670,0.043980599,0.080537209,0.037739408,CASP3/RAF1,2
BP,GO:0042417,dopamine metabolic process,2/160,39/18670,0.043980599,0.080537209,0.037739408,SLC6A3/MAOA,2
BP,GO:0045684,positive regulation of epidermis development,2/160,39/18670,0.043980599,0.080537209,0.037739408,PPARD/HPSE,2
BP,GO:0045911,positive regulation of DNA recombination,2/160,39/18670,0.043980599,0.080537209,0.037739408,IL4/PARP1,2
BP,GO:0051930,regulation of sensory perception of pain,2/160,39/18670,0.043980599,0.080537209,0.037739408,OPRM1/ADRA2C,2
BP,GO:2000648,positive regulation of stem cell proliferation,2/160,39/18670,0.043980599,0.080537209,0.037739408,VEGFA/HIF1A,2
BP,GO:0045665,negative regulation of neuron differentiation,5/160,225/18670,0.044618445,0.081667871,0.038269231,SLC6A4/SPP1/MDM2/APP/PPP3CA,5
BP,GO:0019882,antigen processing and presentation,5/160,226/18670,0.045325485,0.082924093,0.038857892,ICAM1/NCF1/CHUK/CTSD/IKBKB,5
BP,GO:0032092,positive regulation of protein binding,3/160,93/18670,0.045820402,0.083676582,0.039210505,MMP9/CAV1/APP,3
BP,GO:0035249,"synaptic transmission, glutamatergic",3/160,93/18670,0.045820402,0.083676582,0.039210505,PTGS2/CCL2/EGFR,3
BP,GO:0046634,regulation of alpha-beta T cell activation,3/160,93/18670,0.045820402,0.083676582,0.039210505,IL6R/IFNG/IRF1,3
BP,GO:0051952,regulation of amine transport,3/160,93/18670,0.045820402,0.083676582,0.039210505,ADRA2A/ADRA2C/ADRA2B,3
BP,GO:0001990,regulation of systemic arterial blood pressure by hormone,2/160,40/18670,0.046040775,0.083811379,0.039273671,NOS3/ECE1,2
BP,GO:0002369,T cell cytokine production,2/160,40/18670,0.046040775,0.083811379,0.039273671,IL4/IL1B,2
BP,GO:0006734,NADH metabolic process,2/160,40/18670,0.046040775,0.083811379,0.039273671,TP53/HK2,2
BP,GO:0007618,mating,2/160,40/18670,0.046040775,0.083811379,0.039273671,SLC6A4/APP,2
BP,GO:0008156,negative regulation of DNA replication,2/160,40/18670,0.046040775,0.083811379,0.039273671,TP53/CHEK2,2
BP,GO:0051931,regulation of sensory perception,2/160,40/18670,0.046040775,0.083811379,0.039273671,OPRM1/ADRA2C,2
BP,GO:2000008,regulation of protein localization to cell surface,2/160,40/18670,0.046040775,0.083811379,0.039273671,AKT1/EGF,2
BP,GO:0008544,epidermis development,8/160,464/18670,0.046781215,0.085120548,0.039887142,RELA/BCL2/CASP3/EGFR/SOD1/PPARA/PPARD/HPSE,8
BP,GO:0044728,DNA methylation or demethylation,3/160,94/18670,0.047043449,0.085481129,0.040056108,FOS/MYC/PARP1,3
BP,GO:0045621,positive regulation of lymphocyte differentiation,3/160,94/18670,0.047043449,0.085481129,0.040056108,IL4/IL2RA/IFNG,3
BP,GO:0051289,protein homotetramerization,3/160,94/18670,0.047043449,0.085481129,0.040056108,RXRA/TP53/CAT,3
BP,GO:0006308,DNA catabolic process,2/160,41/18670,0.048135856,0.087189064,0.04085644,BAX/CASP3,2
BP,GO:0007520,myoblast fusion,2/160,41/18670,0.048135856,0.087189064,0.04085644,MAPK14/CXCL10,2
BP,GO:0043267,negative regulation of potassium ion transport,2/160,41/18670,0.048135856,0.087189064,0.04085644,CAV1/NOS3,2
BP,GO:0090279,regulation of calcium ion import,2/160,41/18670,0.048135856,0.087189064,0.04085644,CCL2/EGF,2
BP,GO:0097178,ruffle assembly,2/160,41/18670,0.048135856,0.087189064,0.04085644,CAV1/ICAM1,2
BP,GO:0098815,modulation of excitatory postsynaptic potential,2/160,41/18670,0.048135856,0.087189064,0.04085644,ADRB2/APP,2
BP,GO:1903053,regulation of extracellular matrix organization,2/160,41/18670,0.048135856,0.087189064,0.04085644,DPP4/RB1,2
BP,GO:0002702,positive regulation of production of molecular mediator of immune response,3/160,95/18670,0.048282522,0.08729672,0.040906887,MAPK14/IL4/IL1B,3
BP,GO:0042116,macrophage activation,3/160,95/18670,0.048282522,0.08729672,0.040906887,JUN/IFNG/APP,3
BP,GO:0044070,regulation of anion transport,3/160,95/18670,0.048282522,0.08729672,0.040906887,AKT1/CA2/IL1B,3
BP,GO:0045069,regulation of viral genome replication,3/160,95/18670,0.048282522,0.08729672,0.040906887,BCL2/CXCL8/SLPI,3
BP,GO:0007409,axonogenesis,8/160,468/18670,0.048748025,0.088098575,0.041282633,BCL2/FN1/PRKCA/VEGFA/MAPK1/ERBB2/SPP1/APP,8
BP,GO:0051188,cofactor biosynthetic process,5/160,231/18670,0.048961152,0.088443814,0.04144441,PTGS2/CYP1A2/SOD1/CYP1A1/NFE2L2,5
BP,GO:0002819,regulation of adaptive immune response,4/160,160/18670,0.049002264,0.088478153,0.041460501,IL6R/IL4/IL1B/IRF1,4
BP,GO:0002474,antigen processing and presentation of peptide antigen via MHC class I,3/160,96/18670,0.049537545,0.089364034,0.041875622,NCF1/CHUK/IKBKB,3
BP,GO:0032755,positive regulation of interleukin-6 production,3/160,96/18670,0.049537545,0.089364034,0.041875622,IL6R/IL1B/APP,3
BP,GO:0010970,transport along microtubule,4/160,161/18670,0.049929103,0.089989283,0.042168611,SOD1/HIF1A/HSPB1/APP,4
BP,GO:0032635,interleukin-6 production,4/160,161/18670,0.049929103,0.089989283,0.042168611,NOS2/IL6R/IL1B/APP,4
CC,GO:0045121,membrane raft,23/160,315/19717,1.09E-15,1.72E-13,1.23E-13,SCN5A/PTGS2/DPP4/KDR/CASP3/SLC6A3/SLC6A4/OPRM1/CASP8/EGFR/MAPK1/HMOX1/CAV1/GJA1/ICAM1/SELE/NOS3/SLC2A4/CTSD/HPSE/APP/ADCY2/IKBKB,23
CC,GO:0098857,membrane microdomain,23/160,316/19717,1.16E-15,1.72E-13,1.23E-13,SCN5A/PTGS2/DPP4/KDR/CASP3/SLC6A3/SLC6A4/OPRM1/CASP8/EGFR/MAPK1/HMOX1/CAV1/GJA1/ICAM1/SELE/NOS3/SLC2A4/CTSD/HPSE/APP/ADCY2/IKBKB,23
CC,GO:0098589,membrane region,23/160,328/19717,2.61E-15,2.56E-13,1.84E-13,SCN5A/PTGS2/DPP4/KDR/CASP3/SLC6A3/SLC6A4/OPRM1/CASP8/EGFR/MAPK1/HMOX1/CAV1/GJA1/ICAM1/SELE/NOS3/SLC2A4/CTSD/HPSE/APP/ADCY2/IKBKB,23
CC,GO:0090575,RNA polymerase II transcription regulator complex,13/160,166/19717,1.00E-09,7.30E-08,5.24E-08,PPARG/RXRA/JUN/TP53/FOS/RB1/HIF1A/NR1I2/NR1I3/PPARA/PPARD/E2F1/E2F2,13
CC,GO:0005667,transcription regulator complex,19/160,415/19717,1.24E-09,7.30E-08,5.24E-08,PPARG/RXRA/CDK2/RELA/CCND1/JUN/TP53/FOS/RB1/HIF1A/NR1I2/PARP1/NR1I3/PPARA/PPARD/RUNX2/E2F1/E2F2/CDK4,19
CC,GO:0031983,vesicle lumen,16/160,327/19717,1.07E-08,5.26E-07,3.77E-07,MAPK14/FN1/EGFR/VEGFA/MAPK1/EGF/SERPINE1/ALOX5/MPO/GSTP1/CTSD/IGF2/HPSE/APP/SLPI/CAT,16
CC,GO:1902911,protein kinase complex,10/160,109/19717,2.00E-08,8.42E-07,6.04E-07,CDK2/CCND1/CDKN1A/CCNA2/RB1/CCNB1/INSRR/CHUK/CDK4/IKBKB,10
CC,GO:1902554,serine/threonine protein kinase complex,9/160,88/19717,4.02E-08,1.41E-06,1.01E-06,CDK2/CCND1/CDKN1A/CCNA2/RB1/CCNB1/CHUK/CDK4/IKBKB,9
CC,GO:0000307,cyclin-dependent protein kinase holoenzyme complex,7/160,42/19717,4.32E-08,1.41E-06,1.01E-06,CDK2/CCND1/CDKN1A/CCNA2/RB1/CCNB1/CDK4,7
CC,GO:0034774,secretory granule lumen,15/160,321/19717,5.78E-08,1.70E-06,1.22E-06,MAPK14/FN1/VEGFA/MAPK1/EGF/SERPINE1/ALOX5/MPO/GSTP1/CTSD/IGF2/HPSE/APP/SLPI/CAT,15
CC,GO:0060205,cytoplasmic vesicle lumen,15/160,325/19717,6.79E-08,1.82E-06,1.31E-06,MAPK14/FN1/VEGFA/MAPK1/EGF/SERPINE1/ALOX5/MPO/GSTP1/CTSD/IGF2/HPSE/APP/SLPI/CAT,15
CC,GO:0005741,mitochondrial outer membrane,11/160,178/19717,2.31E-07,5.67E-06,4.07E-06,BCL2/BAX/MCL1/PGR/CASP8/MAOA/BCL2L1/RAF1/GJA1/HK2/HADHB,11
CC,GO:0005901,caveola,8/160,80/19717,2.79E-07,6.32E-06,4.54E-06,SCN5A/PTGS2/SLC6A3/MAPK1/HMOX1/CAV1/SELE/NOS3,8
CC,GO:0031968,organelle outer membrane,11/160,201/19717,7.76E-07,1.64E-05,1.17E-05,BCL2/BAX/MCL1/PGR/CASP8/MAOA/BCL2L1/RAF1/GJA1/HK2/HADHB,11
CC,GO:0019867,outer membrane,11/160,203/19717,8.56E-07,1.68E-05,1.21E-05,BCL2/BAX/MCL1/PGR/CASP8/MAOA/BCL2L1/RAF1/GJA1/HK2/HADHB,11
CC,GO:0000790,nuclear chromatin,14/160,376/19717,2.45E-06,4.52E-05,3.25E-05,ESR1/AR/RXRA/RELA/JUN/TP53/RB1/HIF1A/STAT1/MYC/PPARD/RUNX2/E2F1/IRF1,14
CC,GO:0044853,plasma membrane raft,8/160,109/19717,2.99E-06,5.13E-05,3.68E-05,SCN5A/PTGS2/SLC6A3/MAPK1/HMOX1/CAV1/SELE/NOS3,8
CC,GO:0045177,apical part of cell,14/160,384/19717,3.13E-06,5.13E-05,3.68E-05,DPP4/ADRB2/IL6R/FN1/CA2/EGFR/ERBB2/GJA1/VCAM1/PLAT/CLDN4/ERBB3/CD44/APP,14
CC,GO:0009925,basal plasma membrane,5/160,34/19717,7.60E-06,0.000109986,7.89E-05,EGFR/ERBB2/CLDN4/ERBB3/MET,5
CC,GO:0101002,ficolin-1-rich granule,8/160,124/19717,7.83E-06,0.000109986,7.89E-05,MAPK14/LTA4H/MMP9/MAPK1/ALOX5/GSTP1/CTSD/CAT,8
CC,GO:1904813,ficolin-1-rich granule lumen,8/160,124/19717,7.83E-06,0.000109986,7.89E-05,MAPK14/LTA4H/MMP9/MAPK1/ALOX5/GSTP1/CTSD/CAT,8
CC,GO:0061695,"transferase complex, transferring phosphorus-containing groups",11/160,259/19717,8.99E-06,0.000120552,8.65E-05,CDK2/CCND1/CDKN1A/TP53/CCNA2/RB1/CCNB1/INSRR/CHUK/CDK4/IKBKB,11
CC,GO:0016323,basolateral plasma membrane,10/160,217/19717,1.15E-05,0.000147065,0.000105478,IL6R/CHRM3/ADRA2A/CA2/EGFR/ERBB2/CLDN4/ERBB3/CD44/MET,10
CC,GO:0031093,platelet alpha granule lumen,6/160,67/19717,1.72E-05,0.000211869,0.000151956,FN1/VEGFA/EGF/SERPINE1/IGF2/APP,6
CC,GO:0005925,focal adhesion,13/160,405/19717,2.74E-05,0.000320507,0.000229873,DPP4/SLC6A4/OPRM1/PLAU/EGFR/MAPK1/HSPA5/CAV1/GJA1/ICAM1/HSPB1/CD44/CAT,13
CC,GO:0099056,integral component of presynaptic membrane,6/160,73/19717,2.82E-05,0.000320507,0.000229873,CHRM3/CHRM1/SLC6A3/SLC6A4/OPRM1/HTR3A,6
CC,GO:0030055,cell-substrate junction,13/160,412/19717,3.27E-05,0.000357699,0.000256548,DPP4/SLC6A4/OPRM1/PLAU/EGFR/MAPK1/HSPA5/CAV1/GJA1/ICAM1/HSPB1/CD44/CAT,13
CC,GO:0099055,integral component of postsynaptic membrane,7/160,117/19717,4.77E-05,0.000502769,0.000360595,CHRM3/CHRM1/SLC6A3/SLC6A4/OPRM1/HTR3A/ADRA2C,7
CC,GO:0098889,intrinsic component of presynaptic membrane,6/160,82/19717,5.47E-05,0.00055664,0.000399231,CHRM3/CHRM1/SLC6A3/SLC6A4/OPRM1/HTR3A,6
CC,GO:0045178,basal part of cell,5/160,51/19717,5.74E-05,0.000564826,0.000405103,EGFR/ERBB2/CLDN4/ERBB3/MET,5
CC,GO:0098936,intrinsic component of postsynaptic membrane,7/160,122/19717,6.23E-05,0.000577836,0.000414434,CHRM3/CHRM1/SLC6A3/SLC6A4/OPRM1/HTR3A/ADRA2C,7
CC,GO:0120111,neuron projection cytoplasm,6/160,84/19717,6.27E-05,0.000577836,0.000414434,OPRM1/MAPK1/SOD1/HIF1A/HSPB1/MAP2K4,6
CC,GO:0031970,organelle envelope lumen,6/160,88/19717,8.14E-05,0.000727392,0.000521698,SOD1/ALOX5/HSD3B2/HSD3B1/APP/CAT,6
CC,GO:0031091,platelet alpha granule,6/160,91/19717,9.81E-05,0.000851183,0.000610483,FN1/VEGFA/EGF/SERPINE1/IGF2/APP,6
CC,GO:0062023,collagen-containing extracellular matrix,12/160,406/19717,0.000122921,0.001030836,0.000739333,PRSS1/FN1/ACHE/F7/MMP2/MMP9/F3/ICAM1/SERPINE1/COL1A1/CTSD/SLPI,12
CC,GO:0032839,dendrite cytoplasm,4/160,32/19717,0.000125797,0.001030836,0.000739333,OPRM1/MAPK1/SOD1/MAP2K4,4
CC,GO:0005790,smooth endoplasmic reticulum,4/160,34/19717,0.0001602,0.001277273,0.000916082,HSPA5/HSD3B2/HSD3B1/APP,4
CC,GO:0099699,integral component of synaptic membrane,7/160,152/19717,0.000245609,0.0019067,0.001367517,CHRM3/CHRM1/SLC6A3/SLC6A4/OPRM1/HTR3A/ADRA2C,7
CC,GO:0016324,apical plasma membrane,10/160,318/19717,0.000278949,0.002109999,0.001513326,DPP4/ADRB2/IL6R/FN1/EGFR/ERBB2/GJA1/CLDN4/ERBB3/CD44,10
CC,GO:0099240,intrinsic component of synaptic membrane,7/160,164/19717,0.000389625,0.002873484,0.002060911,CHRM3/CHRM1/SLC6A3/SLC6A4/OPRM1/HTR3A/ADRA2C,7
CC,GO:0005819,spindle,10/160,347/19717,0.000553368,0.003981551,0.002855635,MAPK14/AKT1/MAPK1/RB1/BIRC5/HSPB1/CCNB1/RASSF1/NR3C1/APP,10
CC,GO:0043025,neuronal cell body,12/160,497/19717,0.000762959,0.005200318,0.003729755,CASP3/SLC6A3/OPRM1/HTR3A/ADRA2C/MAPK1/TOP1/SOD1/NCF1/NQO1/APP/MAP2K4,12
CC,GO:0005782,peroxisomal matrix,4/160,51/19717,0.000775641,0.005200318,0.003729755,NOS2/ACOX1/EHHADH/CAT,4
CC,GO:0031907,microbody lumen,4/160,51/19717,0.000775641,0.005200318,0.003729755,NOS2/ACOX1/EHHADH/CAT,4
CC,GO:0042383,sarcolemma,6/160,136/19717,0.000857791,0.005623296,0.004033122,SCN5A/OPRM1/CAV1/VCAM1/SLC2A4/PPP3CA,6
CC,GO:0016328,lateral plasma membrane,4/160,57/19717,0.001180715,0.007571977,0.005430749,SCN5A/GJA1/CLDN4/ERBB3,4
CC,GO:0042734,presynaptic membrane,6/160,161/19717,0.002036748,0.012783842,0.009168786,CHRM3/CHRM1/SLC6A3/SLC6A4/OPRM1/HTR3A,6
CC,GO:0005769,early endosome,9/160,350/19717,0.002280328,0.014014516,0.010051446,ADRB2/KDR/ADRB1/EGFR/MAPK1/CAV1/GJA1/VCAM1/APP,9
CC,GO:0034663,endoplasmic reticulum chaperone complex,2/160,11/19717,0.003430318,0.020238876,0.014515662,HSPA5/UGT1A1,2
CC,GO:0035631,CD40 receptor complex,2/160,11/19717,0.003430318,0.020238876,0.014515662,CHUK/IKBKB,2
CC,GO:0005788,endoplasmic reticulum lumen,8/160,309/19717,0.003802475,0.021994706,0.015774972,PTGS2/FN1/F7/HSPA5/COL1A1/SPP1/IGFBP3/APP,8
CC,GO:0005758,mitochondrial intermembrane space,4/160,79/19717,0.003913689,0.022202661,0.015924121,SOD1/HSD3B2/HSD3B1/CAT,4
CC,GO:0098685,Schaffer collateral - CA1 synapse,4/160,82/19717,0.004471494,0.024888503,0.017850452,CHRM1/ADRB1/PLAT/PPP3CA,4
CC,GO:0005777,peroxisome,5/160,134/19717,0.004766416,0.025108797,0.01800845,NOS2/SOD1/ACOX1/EHHADH/CAT,5
CC,GO:0042579,microbody,5/160,134/19717,0.004766416,0.025108797,0.01800845,NOS2/SOD1/ACOX1/EHHADH/CAT,5
CC,GO:0043204,perikaryon,5/160,134/19717,0.004766416,0.025108797,0.01800845,OPRM1/MAPK1/TOP1/APP/MAP2K4,5
CC,GO:0009897,external side of plasma membrane,9/160,393/19717,0.004882684,0.025270032,0.018124091,IL6R/F3/ICAM1/VCAM1/IL2RA/SLC2A4/CXCL10/CD40LG/ECE1,9
CC,GO:0098793,presynapse,10/160,491/19717,0.006888586,0.034918107,0.025043852,CHRM3/CHRM1/SLC6A3/SLC6A4/OPRM1/HTR3A/ADRA2C/BCL2L1/SLC2A4/APP,10
CC,GO:0005911,cell-cell junction,9/160,416/19717,0.007003246,0.034918107,0.025043852,SCN5A/DPP4/AKT1/CCND1/GJA1/CLDN4/CDK4/APP/PPP3CA,9
CC,GO:0032838,plasma membrane bounded cell projection cytoplasm,6/160,208/19717,0.007101988,0.034918107,0.025043852,OPRM1/MAPK1/SOD1/HIF1A/HSPB1/MAP2K4,6
CC,GO:0043209,myelin sheath,3/160,49/19717,0.007352188,0.035555664,0.025501118,BCL2/CA2/ERBB2,3
CC,GO:0098978,glutamatergic synapse,8/160,349/19717,0.007770566,0.036409383,0.02611342,MAPK14/RELA/CHRM3/CHRM1/HTR3A/ADRA2C/PLAT/PPP3CA,8
CC,GO:0099061,integral component of postsynaptic density membrane,3/160,50/19717,0.007775563,0.036409383,0.02611342,CHRM3/CHRM1/ADRA2C,3
CC,GO:0005771,multivesicular body,3/160,51/19717,0.008213058,0.037287437,0.026743175,EGFR/GJA1/SLC2A4,3
CC,GO:0031143,pseudopodium,2/160,17/19717,0.008215876,0.037287437,0.026743175,MAPK1/RAF1,2
CC,GO:0099146,intrinsic component of postsynaptic density membrane,3/160,53/19717,0.00913081,0.04048083,0.02903353,CHRM3/CHRM1/ADRA2C,3
CC,GO:0016327,apicolateral plasma membrane,2/160,18/19717,0.009193951,0.04048083,0.02903353,THBD/CLDN4,2
CC,GO:1904724,tertiary granule lumen,3/160,55/19717,0.010106193,0.043843044,0.031444966,LTA4H/MMP9/CTSD,3
CC,GO:1904115,axon cytoplasm,3/160,57/19717,0.011139874,0.047626998,0.034158882,SOD1/HIF1A/HSPB1,3
CC,GO:0030139,endocytic vesicle,7/160,303/19717,0.012000493,0.050573507,0.036272168,DPP4/EGFR/CAV1/NOS3/MPO/NCF1/MDM2,7
CC,GO:0031258,lamellipodium membrane,2/160,22/19717,0.013590049,0.055875594,0.040074913,DPP4/CD44,2
CC,GO:0005635,nuclear envelope,9/160,464/19717,0.013637433,0.055875594,0.040074913,BCL2/BAX/EGFR/BCL2L1/SULT1E1/ALOX5/PARP1/CDK4/APP,9
CC,GO:0035580,specific granule lumen,3/160,62/19717,0.013982796,0.056505821,0.040526923,CTSD/HPSE/SLPI,3
CC,GO:0046930,pore complex,2/160,23/19717,0.014805836,0.059023264,0.042332475,BCL2/BAX,2
CC,GO:0045211,postsynaptic membrane,7/160,323/19717,0.016513603,0.064953504,0.046585742,CHRM3/CHRM1/SLC6A3/SLC6A4/OPRM1/HTR3A/ADRA2C,7
CC,GO:0099568,cytoplasmic region,6/160,251/19717,0.016765753,0.065077593,0.046674741,OPRM1/MAPK1/SOD1/HIF1A/HSPB1/MAP2K4,6
MF,GO:0004879,nuclear receptor activity,11/160,47/17696,3.07E-13,7.21E-11,4.25E-11,ESR1/AR/PPARG/RXRA/PGR/ESR2/NR1I2/NR1I3/PPARA/PPARD/NR3C1,11
MF,GO:0098531,ligand-activated transcription factor activity,11/160,47/17696,3.07E-13,7.21E-11,4.25E-11,ESR1/AR/PPARG/RXRA/PGR/ESR2/NR1I2/NR1I3/PPARA/PPARD/NR3C1,11
MF,GO:0003707,steroid hormone receptor activity,11/160,56/17696,2.45E-12,3.83E-10,2.26E-10,ESR1/AR/PPARG/RXRA/PGR/ESR2/NR1I2/NR1I3/PPARA/PPARD/NR3C1,11
MF,GO:0044389,ubiquitin-like protein ligase binding,17/160,308/17696,2.90E-09,3.29E-07,1.94E-07,SCN5A/RELA/BCL2/CDKN1A/JUN/TP53/CASP8/EGFR/RB1/NFKBIA/HIF1A/STAT1/HSPA5/CCNB1/CHEK2/ERBB3/MDM2,17
MF,GO:0020037,heme binding,12/160,135/17696,3.50E-09,3.29E-07,1.94E-07,NOS2/PTGS1/PTGS2/CYP3A4/CYP1A2/CYP2B6/HMOX1/CYP1A1/NOS3/CYP1B1/MPO/CAT,12
MF,GO:0046906,tetrapyrrole binding,12/160,145/17696,7.90E-09,6.19E-07,3.65E-07,NOS2/PTGS1/PTGS2/CYP3A4/CYP1A2/CYP2B6/HMOX1/CYP1A1/NOS3/CYP1B1/MPO/CAT,12
MF,GO:0019902,phosphatase binding,13/160,185/17696,1.34E-08,8.53E-07,5.02E-07,PPARG/MAPK14/AKT1/BCL2/TP53/SLC6A3/EGFR/MAPK1/SOD1/STAT1/ERBB2/PPARA/MET,13
MF,GO:1901338,catecholamine binding,6/160,20/17696,1.74E-08,8.53E-07,5.02E-07,ADRB2/SLC6A3/ADRA2A/ADRB1/ADRA2C/ADRA2B,6
MF,GO:0001228,"DNA-binding transcription activator activity, RNA polymerase II-specific",19/160,439/17696,1.75E-08,8.53E-07,5.02E-07,ESR1/AR/RELA/JUN/TP53/PGR/FOS/HIF1A/STAT1/MYC/NR1I2/NFE2L2/PARP1/NR1I3/PPARA/RUNX2/E2F2/IRF1/NR3C1,19
MF,GO:0001216,DNA-binding transcription activator activity,19/160,440/17696,1.81E-08,8.53E-07,5.02E-07,ESR1/AR/RELA/JUN/TP53/PGR/FOS/HIF1A/STAT1/MYC/NR1I2/NFE2L2/PARP1/NR1I3/PPARA/RUNX2/E2F2/IRF1/NR3C1,19
MF,GO:0140297,DNA-binding transcription factor binding,17/160,351/17696,2.03E-08,8.68E-07,5.11E-07,ESR1/PPARG/RXRA/MAPK14/RELA/JUN/FOS/RB1/NFKBIA/HIF1A/STAT1/MYC/NFE2L2/PARP1/PPARA/PPARD/RUNX2,17
MF,GO:0016705,"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen",12/160,159/17696,2.24E-08,8.76E-07,5.16E-07,NOS2/PTGS1/PTGS2/CYP3A4/CYP1A2/CYP2B6/POR/HMOX1/CYP1A1/NOS3/CYP1B1/TYR,12
MF,GO:0061629,RNA polymerase II-specific DNA-binding transcription factor binding,15/160,277/17696,3.35E-08,1.21E-06,7.13E-07,ESR1/PPARG/RXRA/MAPK14/RELA/JUN/FOS/RB1/NFKBIA/HIF1A/STAT1/NFE2L2/PARP1/PPARA/PPARD,15
MF,GO:0005126,cytokine receptor binding,15/160,286/17696,5.11E-08,1.71E-06,1.01E-06,IL6R/CASP3/CCL2/CXCL8/CASP8/IL4/VEGFA/STAT1/IL1B/IFNG/IL1A/CXCL11/CXCL2/CXCL10/CD40LG,15
MF,GO:0019903,protein phosphatase binding,11/160,140/17696,5.81E-08,1.80E-06,1.06E-06,PPARG/MAPK14/AKT1/BCL2/TP53/SLC6A3/EGFR/SOD1/STAT1/ERBB2/MET,11
MF,GO:0031625,ubiquitin protein ligase binding,15/160,290/17696,6.13E-08,1.80E-06,1.06E-06,SCN5A/RELA/BCL2/CDKN1A/JUN/TP53/CASP8/EGFR/RB1/NFKBIA/HIF1A/HSPA5/CHEK2/ERBB3/MDM2,15
MF,GO:0097153,cysteine-type endopeptidase activity involved in apoptotic process,5/160,15/17696,1.58E-07,4.38E-06,2.58E-06,CASP9/CASP3/CASP8/CASP7/CASP1,5
MF,GO:0005496,steroid binding,9/160,95/17696,1.95E-07,5.09E-06,3.00E-06,ESR1/AR/PGR/ESR2/CYP3A4/CAV1/SULT1E1/NR3C1/UGT1A1,9
MF,GO:0004935,adrenergic receptor activity,5/160,17/17696,3.22E-07,7.96E-06,4.69E-06,ADRB2/ADRA2A/ADRB1/ADRA2C/ADRA2B,5
MF,GO:0004175,endopeptidase activity,17/160,427/17696,3.39E-07,7.96E-06,4.69E-06,DPP4/PRSS1/CASP9/CASP3/MMP1/CASP8/PLAU/F7/MMP2/MMP9/MMP3/F3/PLAT/CTSD/CASP7/ECE1/CASP1,17
MF,GO:0019207,kinase regulator activity,12/160,207/17696,4.04E-07,9.04E-06,5.32E-06,CCND1/CDKN1A/CASP3/CCNA2/EGF/HSPB1/CCNB1/GSTP1/CXCL10/IGF2/ERBB3/CDK4,12
MF,GO:0019838,growth factor binding,10/160,137/17696,4.72E-07,1.01E-05,5.94E-06,SCN5A/KDR/IL6R/EGFR/IL10RA/ERBB2/IL2RA/COL1A1/IGFBP3/ERBB3,10
MF,GO:0019887,protein kinase regulator activity,11/160,180/17696,7.42E-07,1.51E-05,8.92E-06,CCND1/CDKN1A/CASP3/CCNA2/EGF/HSPB1/CCNB1/CXCL10/IGF2/ERBB3/CDK4,11
MF,GO:0005125,cytokine activity,12/160,220/17696,7.73E-07,1.51E-05,8.92E-06,CCL2/CXCL8/IL4/VEGFA/IL1B/IFNG/IL1A/CXCL11/CXCL2/CXCL10/SPP1/CD40LG,12
MF,GO:0008227,G protein-coupled amine receptor activity,7/160,59/17696,9.96E-07,1.72E-05,1.01E-05,ADRB2/CHRM3/CHRM1/ADRA2A/ADRB1/ADRA2C/ADRA2B,7
MF,GO:0097110,scaffold protein binding,7/160,59/17696,9.96E-07,1.72E-05,1.01E-05,SCN5A/CASP8/GJA1/NOS3/CHUK/MDM2/IKBKB,7
MF,GO:0016825,"hydrolase activity, acting on acid phosphorus-nitrogen bonds",11/160,186/17696,1.03E-06,1.72E-05,1.01E-05,DPP4/PRSS1/MMP1/ACHE/PLAU/F7/MMP2/MMP9/MMP3/F3/PLAT,11
MF,GO:0017171,serine hydrolase activity,11/160,186/17696,1.03E-06,1.72E-05,1.01E-05,DPP4/PRSS1/MMP1/ACHE/PLAU/F7/MMP2/MMP9/MMP3/F3/PLAT,11
MF,GO:0051400,BH domain binding,4/160,10/17696,1.30E-06,2.03E-05,1.20E-05,BCL2/BAX/MCL1/BCL2L1,4
MF,GO:0070513,death domain binding,4/160,10/17696,1.30E-06,2.03E-05,1.20E-05,BCL2/BAX/MCL1/BCL2L1,4
MF,GO:0004252,serine-type endopeptidase activity,10/160,160/17696,1.96E-06,2.97E-05,1.75E-05,DPP4/PRSS1/MMP1/PLAU/F7/MMP2/MMP9/MMP3/F3/PLAT,10
MF,GO:0002020,protease binding,9/160,128/17696,2.45E-06,3.60E-05,2.12E-05,DPP4/BCL2/CASP3/TP53/FN1/SLC6A3/F3/SERPINE1/COL1A1,9
MF,GO:0005178,integrin binding,9/160,132/17696,3.17E-06,4.42E-05,2.60E-05,KDR/FN1/PRKCA/EGFR/ICAM1/IL1B/VCAM1/SPP1/IGF2,9
MF,GO:0004497,monooxygenase activity,8/160,99/17696,3.20E-06,4.42E-05,2.60E-05,NOS2/CYP3A4/CYP1A2/CYP2B6/CYP1A1/NOS3/CYP1B1/TYR,8
MF,GO:0070491,repressing transcription factor binding,7/160,71/17696,3.54E-06,4.76E-05,2.80E-05,PPARG/RELA/STAT1/MYC/PPARA/PPARD/RUNX2,7
MF,GO:0016653,"oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor",4/160,13/17696,4.32E-06,5.64E-05,3.32E-05,NOS2/POR/NOS3/NQO1,4
MF,GO:0016538,cyclin-dependent protein serine/threonine kinase regulator activity,6/160,49/17696,5.04E-06,6.41E-05,3.77E-05,CCND1/CDKN1A/CASP3/CCNA2/CCNB1/CDK4,6
MF,GO:0008236,serine-type peptidase activity,10/160,182/17696,6.21E-06,7.68E-05,4.53E-05,DPP4/PRSS1/MMP1/PLAU/F7/MMP2/MMP9/MMP3/F3/PLAT,10
MF,GO:0030546,signaling receptor activator activity,16/160,487/17696,9.02E-06,0.000107559,6.34E-05,IL6R/CCL2/CXCL8/IL4/VEGFA/EGF/IL1B/IFNG/IL1A/CXCL11/CXCL2/CXCL10/SPP1/IGF2/CD40LG/APP,16
MF,GO:0016712,"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen",5/160,32/17696,9.38E-06,0.000107559,6.34E-05,CYP3A4/CYP1A2/CYP2B6/CYP1A1/CYP1B1,5
MF,GO:0051721,protein phosphatase 2A binding,5/160,32/17696,9.38E-06,0.000107559,6.34E-05,AKT1/BCL2/TP53/SLC6A3/STAT1,5
MF,GO:0031406,carboxylic acid binding,10/160,193/17696,1.04E-05,0.000116543,6.86E-05,NOS2/PPARG/RXRA/SELE/NOS3/PPARA/PPARD/CD44/UGT1A1/ACOX1,10
MF,GO:0097718,disordered domain specific binding,5/160,33/17696,1.10E-05,0.000119991,7.07E-05,TP53/FN1/RB1/GJA1/MDM2,5
MF,GO:0033613,activating transcription factor binding,7/160,85/17696,1.18E-05,0.00012643,7.45E-05,PPARG/RELA/JUN/FOS/RB1/MYC/NFE2L2,7
MF,GO:0016209,antioxidant activity,7/160,86/17696,1.28E-05,0.000133562,7.87E-05,PTGS1/PTGS2/SOD1/MPO/GSTP1/NQO1/CAT,7
MF,GO:0043177,organic acid binding,10/160,205/17696,1.76E-05,0.000179843,0.000105932,NOS2/PPARG/RXRA/SELE/NOS3/PPARA/PPARD/CD44/UGT1A1/ACOX1,10
MF,GO:0004714,transmembrane receptor protein tyrosine kinase activity,6/160,62/17696,2.01E-05,0.000201256,0.000118545,KDR/EGFR/ERBB2/INSRR/ERBB3/MET,6
MF,GO:0008395,steroid hydroxylase activity,5/160,38/17696,2.24E-05,0.000219197,0.000129113,CYP3A4/CYP1A2/CYP2B6/CYP1A1/CYP1B1,5
MF,GO:0033293,monocarboxylic acid binding,6/160,64/17696,2.42E-05,0.000231956,0.000136628,PPARG/RXRA/PPARA/PPARD/UGT1A1/ACOX1,6
MF,GO:0042379,chemokine receptor binding,6/160,66/17696,2.89E-05,0.000271409,0.000159867,CCL2/CXCL8/STAT1/CXCL11/CXCL2/CXCL10,6
MF,GO:0048018,receptor ligand activity,15/160,482/17696,3.27E-05,0.000301016,0.000177306,IL6R/CCL2/CXCL8/IL4/VEGFA/EGF/IL1B/IFNG/IL1A/CXCL11/CXCL2/CXCL10/SPP1/IGF2/CD40LG,15
MF,GO:0004674,protein serine/threonine kinase activity,14/160,439/17696,4.64E-05,0.000419612,0.000247162,MAPK14/CDK2/AKT1/PRKCA/EGFR/MAPK1/TOP1/RAF1/CHEK2/CHUK/CDK4/IKBKB/MAPK8/MAP2K4,14
MF,GO:0008009,chemokine activity,5/160,49/17696,7.85E-05,0.000696125,0.000410036,CCL2/CXCL8/CXCL11/CXCL2/CXCL10,5
MF,GO:0019199,transmembrane receptor protein kinase activity,6/160,79/17696,8.02E-05,0.000698004,0.000411142,KDR/EGFR/ERBB2/INSRR/ERBB3/MET,6
MF,GO:0004601,peroxidase activity,5/160,52/17696,0.000104681,0.00087857,0.0005175,PTGS1/PTGS2/MPO/GSTP1/CAT,5
MF,GO:0050661,NADP binding,5/160,52/17696,0.000104681,0.00087857,0.0005175,NOS2/POR/NOS3/G6PD/CAT,5
MF,GO:0045236,CXCR chemokine receptor binding,3/160,11/17696,0.000113485,0.000935756,0.000551184,CXCL8/CXCL11/CXCL10,3
MF,GO:0016684,"oxidoreductase activity, acting on peroxide as acceptor",5/160,56/17696,0.000149446,0.001211029,0.000713327,PTGS1/PTGS2/MPO/GSTP1/CAT,5
MF,GO:0008179,adenylate cyclase binding,3/160,13/17696,0.000194107,0.001546278,0.000910798,ADRB2/RAF1/ADCY2,3
MF,GO:0004713,protein tyrosine kinase activity,7/160,134/17696,0.000217585,0.001676478,0.000987489,KDR/EGFR/ERBB2/INSRR/ERBB3/MET/MAP2K4,7
MF,GO:0070851,growth factor receptor binding,7/160,134/17696,0.000217585,0.001676478,0.000987489,IL6R/IL4/VEGFA/EGF/IL1B/IL1A/APP,7
MF,GO:0005504,fatty acid binding,4/160,34/17696,0.000241615,0.001774489,0.00104522,PPARG/PPARA/PPARD/ACOX1,4
MF,GO:0004707,MAP kinase activity,3/160,14/17696,0.000245408,0.001774489,0.00104522,MAPK14/MAPK1/MAPK8,3
MF,GO:0016863,"intramolecular oxidoreductase activity, transposing C=C bonds",3/160,14/17696,0.000245408,0.001774489,0.00104522,HSD3B2/HSD3B1/EHHADH,3
MF,GO:0050998,nitric-oxide synthase binding,3/160,14/17696,0.000245408,0.001774489,0.00104522,SCN5A/SLC6A4/CAV1,3
MF,GO:0042562,hormone binding,6/160,102/17696,0.000327583,0.002297971,0.001353564,AR/CHRM3/ACHE/EGFR/NR3C1/ECE1,6
MF,GO:0051087,chaperone binding,6/160,102/17696,0.000327583,0.002297971,0.001353564,BAX/TP53/FN1/SOD1/HSPA5/BIRC5,6
MF,GO:0030374,nuclear receptor transcription coactivator activity,5/160,67/17696,0.000348854,0.002411198,0.001420258,PPARG/NR1I2/NR1I3/PPARA/PPARD,5
MF,GO:0042277,peptide binding,10/160,295/17696,0.000359205,0.002440856,0.001437727,PPARG/RXRA/ADRB2/ACHE/OPRM1/NFKBIA/GSTP1/GSTM1/ECE1/PPP3CA,10
MF,GO:0004708,MAP kinase kinase activity,3/160,16/17696,0.000372566,0.002440856,0.001437727,MAPK14/MAPK1/MAP2K4,3
MF,GO:0010181,FMN binding,3/160,16/17696,0.000372566,0.002440856,0.001437727,NOS2/POR/NOS3,3
MF,GO:0016504,peptidase activator activity,4/160,38/17696,0.000373918,0.002440856,0.001437727,FN1/CAV1/APP/CASP1,4
MF,GO:0035173,histone kinase activity,3/160,17/17696,0.000449406,0.002893437,0.001704309,CDK2/PRKCA/CCNB1,3
MF,GO:0047485,protein N-terminus binding,6/160,109/17696,0.00046777,0.002933894,0.001728139,RELA/TP53/SLC6A3/PARP1/MDM2/ACOX1,6
MF,GO:0035257,nuclear hormone receptor binding,7/160,152/17696,0.000468175,0.002933894,0.001728139,ESR1/PPARG/RXRA/RB1/HIF1A/STAT1/PARP1,7
MF,GO:0051879,Hsp90 protein binding,4/160,41/17696,0.000502312,0.003066059,0.001805988,KDR/HIF1A/CYP1A1/NR3C1,4
MF,GO:0099528,G protein-coupled neurotransmitter receptor activity,4/160,41/17696,0.000502312,0.003066059,0.001805988,CHRM3/CHRM1/OPRM1/ADRB1,4
MF,GO:0042826,histone deacetylase binding,6/160,111/17696,0.000515349,0.003105308,0.001829106,RELA/CCND1/TP53/HIF1A/PARP1/MAPK8,6
MF,GO:0001221,transcription cofactor binding,4/160,43/17696,0.000603607,0.003546189,0.002088796,ESR1/RELA/NFE2L2/PPARA,4
MF,GO:0004712,protein serine/threonine/tyrosine kinase activity,4/160,43/17696,0.000603607,0.003546189,0.002088796,MAPK14/AKT1/MAPK1/MAP2K4,4
MF,GO:0031690,adrenergic receptor binding,3/160,19/17696,0.000631958,0.003666917,0.002159909,ADRA2A/ADRB1/ADRA2C,3
MF,GO:0001091,RNA polymerase II general transcription initiation factor binding,3/160,20/17696,0.000738564,0.004215641,0.002483121,ESR1/AR/TP53,3
MF,GO:0031072,heat shock protein binding,6/160,119/17696,0.000744464,0.004215641,0.002483121,BAX/KDR/HIF1A/HSPA5/CYP1A1/NR3C1,6
MF,GO:0032813,tumor necrosis factor receptor superfamily binding,4/160,46/17696,0.00078155,0.004370238,0.002574183,CASP3/CASP8/STAT1/CD40LG,4
MF,GO:0030295,protein kinase activator activity,5/160,80/17696,0.000790362,0.004370238,0.002574183,CDKN1A/EGF/CCNB1/IGF2/ERBB3,5
MF,GO:0061134,peptidase regulator activity,8/160,219/17696,0.000864525,0.004724732,0.002782989,FN1/CAV1/BIRC5/SERPINE1/APP/XIAP/SLPI/CASP1,8
MF,GO:0001664,G protein-coupled receptor binding,9/160,280/17696,0.001029562,0.005562002,0.003276162,CCL2/CXCL8/ADRA2A/ADRB1/ADRA2C/STAT1/CXCL11/CXCL2/CXCL10,9
MF,GO:0019209,kinase activator activity,5/160,86/17696,0.00109639,0.005855717,0.003449168,CDKN1A/EGF/CCNB1/IGF2/ERBB3,5
MF,GO:0001223,transcription coactivator binding,3/160,23/17696,0.001124777,0.005873833,0.003459839,ESR1/RELA/PPARA,3
MF,GO:0070412,R-SMAD binding,3/160,23/17696,0.001124777,0.005873833,0.003459839,JUN/FOS/PARP1,3
MF,GO:0001102,RNA polymerase II activating transcription factor binding,4/160,53/17696,0.001335418,0.006897212,0.004062635,JUN/FOS/RB1/NFE2L2,4
MF,GO:0051427,hormone receptor binding,7/160,185/17696,0.001483708,0.007579814,0.004464706,ESR1/PPARG/RXRA/RB1/HIF1A/STAT1/PARP1,7
MF,GO:0033218,amide binding,10/160,356/17696,0.001513549,0.007649118,0.004505528,PPARG/RXRA/ADRB2/ACHE/OPRM1/NFKBIA/GSTP1/GSTM1/ECE1/PPP3CA,10
MF,GO:0042165,neurotransmitter binding,4/160,55/17696,0.001533785,0.007668926,0.004517195,CHRM3/ACHE/SLC6A4/HTR3A,4
MF,GO:0004896,cytokine receptor activity,5/160,96/17696,0.001790314,0.008857343,0.005217203,IL6R/IL10RA/F3/IL2RA/CD44,5
MF,GO:0005507,copper ion binding,4/160,59/17696,0.001990418,0.009712978,0.005721194,TP53/SOD1/IL1A/TYR,4
MF,GO:1901681,sulfur compound binding,8/160,250/17696,0.002004593,0.009712978,0.005721194,FN1/VEGFA/MPO/GSTP1/CXCL11/CXCL10/GSTM1/APP,8
MF,GO:0035035,histone acetyltransferase binding,3/160,29/17696,0.002230372,0.010588636,0.00623698,TP53/HIF1A/STAT1,3
MF,GO:0051059,NF-kappaB binding,3/160,29/17696,0.002230372,0.010588636,0.00623698,RELA/NFKBIA/PPARD,3
MF,GO:0004222,metalloendopeptidase activity,5/160,103/17696,0.002437971,0.011343934,0.006681869,MMP1/MMP2/MMP9/MMP3/ECE1,5
MF,GO:0030332,cyclin binding,3/160,30/17696,0.002461875,0.011343934,0.006681869,CDK2/CDKN1A/CDK4,3
MF,GO:0097472,cyclin-dependent protein kinase activity,3/160,30/17696,0.002461875,0.011343934,0.006681869,CDK2/CCNA2/CDK4,3
MF,GO:0003713,transcription coactivator activity,9/160,319/17696,0.002514032,0.011471798,0.006757185,PPARG/RXRA/JUN/ESR2/RB1/NR1I2/NR1I3/PPARA/PPARD,9
MF,GO:0005506,iron ion binding,6/160,152/17696,0.002607576,0.011784238,0.00694122,CYP3A4/CYP1A2/CYP2B6/CYP1A1/CYP1B1/ALOX5,6
MF,GO:0005164,tumor necrosis factor receptor binding,3/160,31/17696,0.002707709,0.012120222,0.007139123,CASP8/STAT1/CD40LG,3
MF,GO:0016651,"oxidoreductase activity, acting on NAD(P)H",5/160,107/17696,0.002876623,0.012754839,0.007512929,NOS2/POR/NOS3/NCF1/NQO1,5
MF,GO:0030291,protein serine/threonine kinase inhibitor activity,3/160,32/17696,0.002968162,0.01303772,0.007679553,CDKN1A/CASP3/HSPB1,3
MF,GO:0002039,p53 binding,4/160,66/17696,0.003001852,0.013063616,0.007694806,TP53/TEP1/HIF1A/MDM2,4
MF,GO:0005518,collagen binding,4/160,67/17696,0.003170297,0.013670086,0.008052033,FN1/ACHE/MMP9/CD44,4
MF,GO:0016922,nuclear receptor binding,5/160,110/17696,0.003241134,0.013848483,0.008157113,ESR1/PPARG/RXRA/RB1/PARP1,5
MF,GO:0015378,sodium:chloride symporter activity,2/160,10/17696,0.003485866,0.014498735,0.008540128,SLC6A3/SLC6A4,2
MF,GO:0043176,amine binding,2/160,10/17696,0.003485866,0.014498735,0.008540128,SLC6A4/HTR3A,2
MF,GO:0051378,serotonin binding,2/160,10/17696,0.003485866,0.014498735,0.008540128,SLC6A4/HTR3A,2
MF,GO:0001103,RNA polymerase II repressing transcription factor binding,3/160,35/17696,0.003839933,0.015831305,0.009325046,PPARG/PPARA/PPARD,3
MF,GO:0004197,cysteine-type endopeptidase activity,5/160,116/17696,0.004068187,0.016626503,0.009793439,CASP9/CASP3/CASP8/CASP7/CASP1,5
MF,GO:0019825,oxygen binding,3/160,36/17696,0.004161508,0.016727592,0.009852983,CYP3A4/CYP1A1/CYP1B1,3
MF,GO:0030594,neurotransmitter receptor activity,5/160,117/17696,0.004219402,0.016727592,0.009852983,CHRM3/CHRM1/OPRM1/ADRB1/HTR3A,5
MF,GO:0005536,glucose binding,2/160,11/17696,0.004235284,0.016727592,0.009852983,HK2/G6PD,2
MF,GO:0043295,glutathione binding,2/160,11/17696,0.004235284,0.016727592,0.009852983,GSTP1/GSTM1,2
MF,GO:0008201,heparin binding,6/160,169/17696,0.004392457,0.017203791,0.010133476,FN1/VEGFA/MPO/CXCL11/CXCL10/APP,6
MF,GO:0016616,"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor",5/160,119/17696,0.004533805,0.017610649,0.010373126,HSD3B2/HSD3B1/G6PD/EHHADH/HADHB,5
MF,GO:0005539,glycosaminoglycan binding,7/160,229/17696,0.004865874,0.018745579,0.011041629,FN1/VEGFA/MPO/CXCL11/CXCL10/CD44/APP,7
MF,GO:0004861,cyclin-dependent protein serine/threonine kinase inhibitor activity,2/160,12/17696,0.005052279,0.019149767,0.011279706,CDKN1A/CASP3,2
MF,GO:1900750,oligopeptide binding,2/160,12/17696,0.005052279,0.019149767,0.011279706,GSTP1/GSTM1,2
MF,GO:0016709,"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen",3/160,39/17696,0.005222449,0.01963641,0.011566351,NOS2/CYP1A1/NOS3,3
MF,GO:0050660,flavin adenine dinucleotide binding,4/160,79/17696,0.005717394,0.021299005,0.012545662,NOS2/POR/NOS3/ACOX1,4
MF,GO:0050839,cell adhesion molecule binding,11/160,499/17696,0.005755263,0.021299005,0.012545662,KDR/FN1/PRKCA/EGFR/STAT1/HSPA5/ICAM1/IL1B/VCAM1/SPP1/IGF2,11
MF,GO:0015373,anion:sodium symporter activity,2/160,13/17696,0.005935583,0.02160811,0.012727733,SLC6A3/SLC6A4,2
MF,GO:0016725,"oxidoreductase activity, acting on CH or CH2 groups",2/160,13/17696,0.005935583,0.02160811,0.012727733,CYP3A4/CYP1A2,2
MF,GO:0051117,ATPase binding,4/160,80/17696,0.005976711,0.02160811,0.012727733,ESR1/AR/PGR/CAV1,4
MF,GO:0008237,metallopeptidase activity,6/160,181/17696,0.006107972,0.021758817,0.012816504,MMP1/LTA4H/MMP2/MMP9/MMP3/ECE1,6
MF,GO:0016614,"oxidoreductase activity, acting on CH-OH group of donors",5/160,128/17696,0.006157282,0.021758817,0.012816504,HSD3B2/HSD3B1/G6PD/EHHADH/HADHB,5
MF,GO:0140375,immune receptor activity,5/160,128/17696,0.006157282,0.021758817,0.012816504,IL6R/IL10RA/F3/IL2RA/CD44,5
MF,GO:0030331,estrogen receptor binding,3/160,42/17696,0.006432084,0.022228524,0.013093173,ESR1/PPARG/PARP1,3
MF,GO:0043028,cysteine-type endopeptidase regulator activity involved in apoptotic process,3/160,42/17696,0.006432084,0.022228524,0.013093173,BIRC5/XIAP/CASP1,3
MF,GO:0140296,general transcription initiation factor binding,3/160,42/17696,0.006432084,0.022228524,0.013093173,ESR1/AR/TP53,3
MF,GO:0036041,long-chain fatty acid binding,2/160,14/17696,0.006883945,0.023616454,0.0139107,PPARG/PPARD,2
MF,GO:0016829,lyase activity,6/160,187/17696,0.007128452,0.024241107,0.014278636,CA2/ODC1/CYP1A1/ADCY2/EHHADH/HADHB,6
MF,GO:0004857,enzyme inhibitor activity,9/160,375/17696,0.007169178,0.024241107,0.014278636,CDKN1A/CASP3/BIRC5/HSPB1/SERPINE1/APP/XIAP/UGT1A1/SLPI,9
MF,GO:0001046,core promoter sequence-specific DNA binding,3/160,45/17696,0.007795387,0.026170227,0.015414938,TP53/FOS/STAT1,3
MF,GO:0016860,intramolecular oxidoreductase activity,3/160,47/17696,0.008791754,0.029280112,0.01724674,HSD3B2/HSD3B1/EHHADH,3
MF,GO:0005149,interleukin-1 receptor binding,2/160,16/17696,0.008970928,0.029280112,0.01724674,IL1B/IL1A,2
MF,GO:0015377,cation:chloride symporter activity,2/160,16/17696,0.008970928,0.029280112,0.01724674,SLC6A3/SLC6A4,2
MF,GO:0016641,"oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor",2/160,16/17696,0.008970928,0.029280112,0.01724674,MAOA/VCAM1,2
MF,GO:0051213,dioxygenase activity,4/160,91/17696,0.009359255,0.030336894,0.017869212,PTGS1/PTGS2/POR/ALOX5,4
MF,GO:0035258,steroid hormone receptor binding,4/160,92/17696,0.009717287,0.031187883,0.018370467,ESR1/PPARG/RB1/PARP1,4
MF,GO:0005516,calmodulin binding,6/160,200/17696,0.009754508,0.031187883,0.018370467,NOS2/SCN5A/AKT1/EGFR/NOS3/PPP3CA,6
MF,GO:0005123,death receptor binding,2/160,17/17696,0.010107131,0.031669009,0.018653862,CASP3/CASP8,2
MF,GO:0008391,arachidonic acid monooxygenase activity,2/160,17/17696,0.010107131,0.031669009,0.018653862,CYP2B6/CYP1A1,2
MF,GO:0042166,acetylcholine binding,2/160,17/17696,0.010107131,0.031669009,0.018653862,CHRM3/ACHE,2
MF,GO:0070888,E-box binding,3/160,50/17696,0.010420272,0.032433959,0.019104437,PPARG/HIF1A/MYC,3
MF,GO:0031435,mitogen-activated protein kinase kinase kinase binding,2/160,18/17696,0.011303557,0.034951789,0.020587504,MAPK1/MAP2K4,2
MF,GO:0001972,retinoic acid binding,2/160,19/17696,0.012559039,0.038082249,0.022431425,RXRA/UGT1A1,2
MF,GO:0015296,anion:cation symporter activity,2/160,19/17696,0.012559039,0.038082249,0.022431425,SLC6A3/SLC6A4,2
MF,GO:0030296,protein tyrosine kinase activator activity,2/160,19/17696,0.012559039,0.038082249,0.022431425,EGF/ERBB3,2
MF,GO:0016638,"oxidoreductase activity, acting on the CH-NH2 group of donors",2/160,20/17696,0.013872426,0.041795128,0.024618407,MAOA/VCAM1,2
MF,GO:0016836,hydro-lyase activity,3/160,56/17696,0.014170312,0.042152194,0.024828728,CA2/EHHADH/HADHB,3
MF,GO:0043621,protein self-association,3/160,56/17696,0.014170312,0.042152194,0.024828728,PPARG/TP53/ACHE,3
MF,GO:0050840,extracellular matrix binding,3/160,57/17696,0.01486023,0.043926465,0.025873819,ACHE/VEGFA/SPP1,3
MF,GO:0008083,growth factor activity,5/160,163/17696,0.016341024,0.048001759,0.028274272,IL6R/IL4/VEGFA/EGF/IGF2,5
MF,GO:0050662,coenzyme binding,7/160,291/17696,0.016776683,0.048975411,0.028847778,NOS2/POR/NOS3/PARP1/G6PD/ACOX1/CAT,7
MF,GO:0015464,acetylcholine receptor activity,2/160,23/17696,0.018148724,0.052330676,0.030824116,CHRM3/CHRM1,2
MF,GO:0044183,protein folding chaperone,2/160,23/17696,0.018148724,0.052330676,0.030824116,HSPA5/HSPB1,2
MF,GO:0004860,protein kinase inhibitor activity,3/160,63/17696,0.019394527,0.055581877,0.032739157,CDKN1A/CASP3/HSPB1,3
MF,GO:0009055,electron transfer activity,4/160,114/17696,0.019943939,0.056810008,0.033462558,CYP1A2/POR/NCF1/NQO1,4
MF,GO:0004190,aspartic-type endopeptidase activity,2/160,25/17696,0.021268692,0.059857995,0.035257901,CASP3/CTSD,2
MF,GO:0043027,cysteine-type endopeptidase inhibitor activity involved in apoptotic process,2/160,25/17696,0.021268692,0.059857995,0.035257901,BIRC5/XIAP,2
MF,GO:0004866,endopeptidase inhibitor activity,5/160,175/17696,0.021498658,0.060145056,0.035426987,BIRC5/SERPINE1/APP/XIAP/SLPI,5
MF,GO:0019210,kinase inhibitor activity,3/160,67/17696,0.02279572,0.06151946,0.036236547,CDKN1A/CASP3/HSPB1,3
MF,GO:0001217,DNA-binding transcription repressor activity,6/160,242/17696,0.022861182,0.06151946,0.036236547,PPARG/RELA/MYC/PPARA/PPARD/E2F1,6
MF,GO:0001227,"DNA-binding transcription repressor activity, RNA polymerase II-specific",6/160,242/17696,0.022861182,0.06151946,0.036236547,PPARG/RELA/MYC/PPARA/PPARD/E2F1,6
MF,GO:0004435,phosphatidylinositol phospholipase C activity,2/160,26/17696,0.022906182,0.06151946,0.036236547,CHRM3/CHRM1,2
MF,GO:0004709,MAP kinase kinase kinase activity,2/160,26/17696,0.022906182,0.06151946,0.036236547,EGFR/RAF1,2
MF,GO:0005328,neurotransmitter:sodium symporter activity,2/160,26/17696,0.022906182,0.06151946,0.036236547,SLC6A3/SLC6A4,2
MF,GO:0070001,aspartic-type peptidase activity,2/160,26/17696,0.022906182,0.06151946,0.036236547,CASP3/CTSD,2
MF,GO:0001968,fibronectin binding,2/160,27/17696,0.024593944,0.064939066,0.038250782,VEGFA/IGFBP3,2
MF,GO:0004364,glutathione transferase activity,2/160,27/17696,0.024593944,0.064939066,0.038250782,GSTP1/GSTM1,2
MF,GO:0016702,"oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen",2/160,27/17696,0.024593944,0.064939066,0.038250782,PTGS2/ALOX5,2
MF,GO:0030414,peptidase inhibitor activity,5/160,182/17696,0.024947421,0.065140489,0.038369426,BIRC5/SERPINE1/APP/XIAP/SLPI,5
MF,GO:0061135,endopeptidase regulator activity,5/160,182/17696,0.024947421,0.065140489,0.038369426,BIRC5/SERPINE1/APP/XIAP/SLPI,5
MF,GO:0098960,postsynaptic neurotransmitter receptor activity,3/160,70/17696,0.025545773,0.066334328,0.039072628,CHRM3/CHRM1/ADRB1,3
MF,GO:0008234,cysteine-type peptidase activity,5/160,184/17696,0.025994335,0.067128227,0.039540255,CASP9/CASP3/CASP8/CASP7/CASP1,5
MF,GO:0004629,phospholipase C activity,2/160,28/17696,0.026330947,0.067258398,0.039616929,CHRM3/CHRM1,2
MF,GO:0016701,"oxidoreductase activity, acting on single donors with incorporation of molecular oxygen",2/160,28/17696,0.026330947,0.067258398,0.039616929,PTGS2/ALOX5,2
MF,GO:0001098,basal transcription machinery binding,3/160,72/17696,0.027473859,0.069423191,0.040892048,ESR1/AR/TP53,3
MF,GO:0001099,basal RNA polymerase II transcription machinery binding,3/160,72/17696,0.027473859,0.069423191,0.040892048,ESR1/AR/TP53,3
MF,GO:0004693,cyclin-dependent protein serine/threonine kinase activity,2/160,29/17696,0.028116175,0.070290438,0.041402878,CDK2/CDK4,2
MF,GO:0033764,"steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor",2/160,29/17696,0.028116175,0.070290438,0.041402878,HSD3B2/HSD3B1,2
MF,GO:0001618,virus receptor activity,3/160,74/17696,0.029477517,0.072918069,0.04295062,DPP4/EGFR/ICAM1,3
MF,GO:0140272,exogenous protein binding,3/160,74/17696,0.029477517,0.072918069,0.04295062,DPP4/EGFR/ICAM1,3
MF,GO:0043325,"phosphatidylinositol-3,4-bisphosphate binding",2/160,30/17696,0.029948625,0.07369557,0.043408589,AKT1/NCF1,2
MF,GO:0016835,carbon-oxygen lyase activity,3/160,75/17696,0.030507609,0.074680085,0.043988494,CA2/EHHADH/HADHB,3