ID,Description,GeneRatio,BgRatio,pvalue,p.adjust,qvalue,geneID,Count
hsa05418,Fluid shear stress and atherosclerosis,32/152,139/8063,1.27E-26,3.23E-24,1.24E-24,MAPK14/RELA/AKT1/BCL2/KDR/JUN/TP53/CCL2/MMP2/MMP9/VEGFA/FOS/HMOX1/CAV1/ICAM1/IL1B/SELE/VCAM1/NOS3/PLAT/THBD/IFNG/IL1A/NCF1/GSTP1/NFE2L2/NQO1/CHUK/GSTM1/IKBKB/MAPK8/MAP2K4,32
hsa04933,AGE-RAGE signaling pathway in diabetic complications,28/152,100/8063,6.40E-26,8.16E-24,3.13E-24,MAPK14/RELA/AKT1/CCND1/BCL2/BAX/JUN/CASP3/CCL2/FN1/CXCL8/PRKCA/MMP2/VEGFA/MAPK1/STAT1/F3/ICAM1/IL1B/SELE/VCAM1/NOS3/THBD/SERPINE1/COL1A1/IL1A/CDK4/MAPK8,28
hsa05215,Prostate cancer,27/152,97/8063,6.21E-25,5.28E-23,2.03E-23,AR/CDK2/RELA/AKT1/CCND1/BCL2/CDKN1A/CASP9/TP53/PLAU/MMP9/MMP3/EGFR/MAPK1/EGF/RB1/NFKBIA/RAF1/ERBB2/PLAT/GSTP1/INSRR/CHUK/E2F1/E2F2/MDM2/IKBKB,27
hsa05219,Bladder cancer,20/152,41/8063,1.72E-24,1.10E-22,4.21E-23,CCND1/CDKN1A/TP53/MMP1/CXCL8/MMP2/MMP9/EGFR/VEGFA/MAPK1/EGF/RB1/RAF1/ERBB2/MYC/RASSF1/E2F1/E2F2/CDK4/MDM2,20
hsa05161,Hepatitis B,30/152,162/8063,5.18E-22,2.64E-20,1.01E-20,MAPK14/CDK2/RELA/AKT1/BCL2/CDKN1A/BAX/CASP9/JUN/CASP3/TP53/CXCL8/CASP8/PRKCA/CCNA2/MMP9/FOS/MAPK1/RB1/NFKBIA/RAF1/STAT1/MYC/BIRC5/CHUK/E2F1/E2F2/IKBKB/MAPK8/MAP2K4,30
hsa05167,Kaposi sarcoma-associated herpesvirus infection,32/152,193/8063,6.56E-22,2.79E-20,1.07E-20,PTGS2/MAPK14/RELA/AKT1/CCND1/CDKN1A/BAX/CASP9/JUN/CASP3/TP53/CXCL8/CASP8/VEGFA/FOS/MAPK1/RB1/NFKBIA/RAF1/HIF1A/STAT1/MYC/ICAM1/CXCL2/CHUK/E2F1/E2F2/CDK4/IKBKB/MAPK8/PPP3CA/MAP2K4,32
hsa05222,Small cell lung cancer,24/152,92/8063,1.74E-21,6.36E-20,2.44E-20,NOS2/PTGS2/RXRA/CDK2/RELA/AKT1/CCND1/BCL2/CDKN1A/BAX/CASP9/CASP3/TP53/FN1/BCL2L1/RB1/NFKBIA/MYC/CHUK/E2F1/E2F2/CDK4/XIAP/IKBKB,24
hsa05212,Pancreatic cancer,22/152,76/8063,7.44E-21,2.37E-19,9.10E-20,RELA/AKT1/CCND1/CDKN1A/BAX/CASP9/TP53/EGFR/VEGFA/BCL2L1/MAPK1/EGF/RB1/RAF1/STAT1/ERBB2/CHUK/E2F1/E2F2/CDK4/IKBKB/MAPK8,22
hsa01522,Endocrine resistance,24/152,98/8063,9.03E-21,2.56E-19,9.83E-20,ESR1/MAPK14/AKT1/CCND1/BCL2/CDKN1A/BAX/JUN/TP53/ESR2/MMP2/MMP9/EGFR/FOS/MAPK1/RB1/RAF1/ERBB2/E2F1/E2F2/CDK4/MDM2/ADCY2/MAPK8,24
hsa04668,TNF signaling pathway,25/152,112/8063,1.56E-20,3.97E-19,1.53E-19,PTGS2/MAPK14/RELA/AKT1/JUN/CASP3/CCL2/CASP8/MMP9/MMP3/FOS/MAPK1/NFKBIA/ICAM1/IL1B/SELE/VCAM1/CXCL2/CXCL10/CHUK/IRF1/CASP7/IKBKB/MAPK8/MAP2K4,25
hsa05160,Hepatitis C,28/152,157/8063,4.17E-20,9.67E-19,3.71E-19,RXRA/CDK2/RELA/AKT1/CCND1/CDKN1A/BAX/CASP9/CASP3/TP53/CASP8/EGFR/MAPK1/EGF/RB1/NFKBIA/RAF1/STAT1/MYC/IFNG/CLDN4/PPARA/CXCL10/CHUK/E2F1/E2F2/CDK4/IKBKB,28
hsa05163,Human cytomegalovirus infection,32/152,225/8063,8.30E-20,1.76E-18,6.77E-19,PTGS2/MAPK14/RELA/AKT1/CCND1/CDKN1A/BAX/CASP9/IL6R/CASP3/TP53/CCL2/CXCL8/CASP8/PRKCA/EGFR/VEGFA/MAPK1/IL10RA/RB1/NFKBIA/RAF1/MYC/IL1B/CHUK/E2F1/E2F2/CDK4/MDM2/ADCY2/IKBKB/PPP3CA,32
hsa04657,IL-17 signaling pathway,22/152,94/8063,1.22E-18,2.39E-17,9.19E-18,PTGS2/MAPK14/RELA/JUN/CASP3/MMP1/CCL2/CXCL8/CASP8/MMP9/IL4/MMP3/FOS/MAPK1/NFKBIA/IL1B/IFNG/CXCL2/CXCL10/CHUK/IKBKB/MAPK8,22
hsa05169,Epstein-Barr virus infection,29/152,202/8063,4.25E-18,7.73E-17,2.97E-17,MAPK14/CDK2/RELA/AKT1/CCND1/BCL2/CDKN1A/BAX/CASP9/JUN/CASP3/TP53/CASP8/CCNA2/RB1/NFKBIA/STAT1/MYC/ICAM1/CXCL10/CHUK/E2F1/E2F2/CD44/CDK4/MDM2/IKBKB/MAPK8/MAP2K4,29
hsa05223,Non-small cell lung cancer,19/152,68/8063,8.30E-18,1.41E-16,5.41E-17,RXRA/AKT1/CCND1/CDKN1A/BAX/CASP9/TP53/PRKCA/EGFR/MAPK1/EGF/RB1/RAF1/ERBB2/RASSF1/E2F1/E2F2/CDK4/MET,19
hsa05205,Proteoglycans in cancer,28/152,205/8063,6.60E-17,1.05E-15,4.04E-16,ESR1/MAPK14/AKT1/CCND1/CDKN1A/KDR/CASP3/TP53/FN1/PRKCA/PLAU/MMP2/MMP9/EGFR/VEGFA/MAPK1/RAF1/HIF1A/ERBB2/CAV1/MYC/COL1A1/IGF2/ERBB3/HPSE/CD44/MDM2/MET,28
hsa04151,PI3K-Akt signaling pathway,35/152,354/8063,1.81E-16,2.71E-15,1.04E-15,RXRA/CDK2/RELA/AKT1/CCND1/BCL2/CDKN1A/CASP9/KDR/IL6R/TP53/FN1/MCL1/CHRM1/PRKCA/IL4/EGFR/VEGFA/BCL2L1/MAPK1/EGF/RAF1/ERBB2/MYC/NOS3/IL2RA/COL1A1/CHUK/SPP1/IGF2/ERBB3/CDK4/MDM2/MET/IKBKB,35
hsa05166,Human T-cell leukemia virus 1 infection,28/152,219/8063,3.86E-16,5.46E-15,2.10E-15,CDK2/RELA/AKT1/CCND1/CDKN1A/BAX/JUN/TP53/CCNA2/BCL2L1/FOS/MAPK1/RB1/NFKBIA/MYC/ICAM1/IL2RA/CHEK2/CHUK/E2F1/E2F2/CDK4/XIAP/ADCY2/IKBKB/MAPK8/PPP3CA/MAP2K4,28
hsa04210,Apoptosis,23/152,136/8063,4.20E-16,5.64E-15,2.16E-15,RELA/AKT1/BCL2/BAX/CASP9/JUN/CASP3/TP53/MCL1/CASP8/BCL2L1/FOS/MAPK1/NFKBIA/RAF1/BIRC5/PARP1/CHUK/CTSD/CASP7/XIAP/IKBKB/MAPK8,23
hsa05220,Chronic myeloid leukemia,18/152,76/8063,1.61E-15,2.05E-14,7.86E-15,RELA/AKT1/CCND1/CDKN1A/BAX/TP53/BCL2L1/MAPK1/RB1/NFKBIA/RAF1/MYC/CHUK/E2F1/E2F2/CDK4/MDM2/IKBKB,18
hsa05162,Measles,22/152,139/8063,8.20E-15,9.96E-14,3.82E-14,CDK2/RELA/AKT1/CCND1/BCL2/BAX/CASP9/JUN/CASP3/TP53/CASP8/BCL2L1/FOS/NFKBIA/STAT1/IL1B/IL2RA/IL1A/CHUK/CDK4/IKBKB/MAPK8,22
hsa04218,Cellular senescence,23/152,156/8063,9.40E-15,1.09E-13,4.18E-14,MAPK14/CDK2/RELA/AKT1/CCND1/CDKN1A/TP53/CXCL8/CCNA2/MAPK1/RB1/RAF1/MYC/CCNB1/SERPINE1/IL1A/CHEK2/E2F1/E2F2/IGFBP3/CDK4/MDM2/PPP3CA,23
hsa05145,Toxoplasmosis,20/152,112/8063,1.36E-14,1.50E-13,5.77E-14,NOS2/MAPK14/RELA/AKT1/BCL2/CASP9/CASP3/CASP8/BCL2L1/MAPK1/IL10RA/NFKBIA/STAT1/IFNG/ALOX5/CHUK/CD40LG/XIAP/IKBKB/MAPK8,20
hsa05164,Influenza A,23/152,171/8063,7.18E-14,7.63E-13,2.93E-13,PRSS1/RELA/AKT1/BAX/CASP9/CASP3/CCL2/CXCL8/CASP8/PRKCA/MAPK1/NFKBIA/RAF1/STAT1/ICAM1/IL1B/IFNG/IL1A/CXCL10/CHUK/CDK4/IKBKB/CASP1,23
hsa04926,Relaxin signaling pathway,20/152,129/8063,2.25E-13,2.27E-12,8.72E-13,NOS2/MAPK14/RELA/AKT1/JUN/MMP1/PRKCA/MMP2/MMP9/EGFR/VEGFA/FOS/MAPK1/NFKBIA/RAF1/NOS3/COL1A1/ADCY2/MAPK8/MAP2K4,20
hsa01524,Platinum drug resistance,16/152,73/8063,2.41E-13,2.27E-12,8.72E-13,AKT1/BCL2/CDKN1A/BAX/CASP9/CASP3/TP53/CASP8/BCL2L1/MAPK1/ERBB2/BIRC5/GSTP1/GSTM1/MDM2/XIAP,16
hsa04115,p53 signaling pathway,16/152,73/8063,2.41E-13,2.27E-12,8.72E-13,CDK2/CCND1/BCL2/CDKN1A/BAX/CASP9/CASP3/TP53/CASP8/BCL2L1/CCNB1/SERPINE1/CHEK2/IGFBP3/CDK4/MDM2,16
hsa05210,Colorectal cancer,17/152,86/8063,2.54E-13,2.31E-12,8.88E-13,AKT1/CCND1/BCL2/CDKN1A/BAX/CASP9/JUN/CASP3/TP53/EGFR/FOS/MAPK1/EGF/RAF1/MYC/BIRC5/MAPK8,17
hsa05142,Chagas disease,18/152,102/8063,3.83E-13,3.37E-12,1.29E-12,NOS2/MAPK14/RELA/AKT1/JUN/CCL2/CXCL8/CASP8/FOS/MAPK1/NFKBIA/IL1B/SERPINE1/IFNG/CHUK/IKBKB/MAPK8/MAP2K4,18
hsa05225,Hepatocellular carcinoma,22/152,168/8063,4.61E-13,3.92E-12,1.50E-12,AKT1/CCND1/CDKN1A/BAX/TP53/PRKCA/EGFR/BCL2L1/MAPK1/RB1/RAF1/HMOX1/MYC/GSTP1/NFE2L2/NQO1/E2F1/E2F2/IGF2/GSTM1/CDK4/MET,22
hsa04620,Toll-like receptor signaling pathway,18/152,104/8063,5.44E-13,4.34E-12,1.66E-12,MAPK14/RELA/AKT1/JUN/CXCL8/CASP8/FOS/MAPK1/NFKBIA/STAT1/IL1B/CXCL11/CXCL10/CHUK/SPP1/IKBKB/MAPK8/MAP2K4,18
hsa04625,C-type lectin receptor signaling pathway,18/152,104/8063,5.44E-13,4.34E-12,1.66E-12,PTGS2/MAPK14/RELA/AKT1/JUN/CASP8/MAPK1/NFKBIA/RAF1/STAT1/IL1B/CHUK/IRF1/MDM2/IKBKB/MAPK8/PPP3CA/CASP1,18
hsa04659,Th17 cell differentiation,18/152,107/8063,9.07E-13,7.01E-12,2.69E-12,RXRA/MAPK14/RELA/JUN/IL6R/IL4/FOS/MAPK1/NFKBIA/HIF1A/STAT1/IL1B/IL2RA/IFNG/CHUK/IKBKB/MAPK8/PPP3CA,18
hsa04066,HIF-1 signaling pathway,18/152,109/8063,1.26E-12,9.47E-12,3.63E-12,NOS2/RELA/AKT1/BCL2/CDKN1A/IL6R/PRKCA/EGFR/VEGFA/MAPK1/EGF/HIF1A/ERBB2/HMOX1/NOS3/SERPINE1/IFNG/HK2,18
hsa05224,Breast cancer,20/152,147/8063,2.81E-12,2.05E-11,7.85E-12,ESR1/AKT1/CCND1/CDKN1A/BAX/JUN/TP53/PGR/ESR2/EGFR/FOS/MAPK1/EGF/RB1/RAF1/ERBB2/MYC/E2F1/E2F2/CDK4,20
hsa05218,Melanoma,15/152,72/8063,3.09E-12,2.19E-11,8.40E-12,AKT1/CCND1/CDKN1A/BAX/TP53/EGFR/MAPK1/EGF/RB1/RAF1/E2F1/E2F2/CDK4/MDM2/MET,15
hsa04010,MAPK signaling pathway,27/152,294/8063,4.83E-12,3.33E-11,1.28E-11,MAPK14/RELA/AKT1/KDR/JUN/CASP3/TP53/PRKCA/EGFR/VEGFA/FOS/MAPK1/EGF/RAF1/ERBB2/MYC/IL1B/HSPB1/IL1A/CHUK/IGF2/ERBB3/MET/IKBKB/MAPK8/PPP3CA/MAP2K4,27
hsa05214,Glioma,15/152,75/8063,5.81E-12,3.90E-11,1.50E-11,AKT1/CCND1/CDKN1A/BAX/TP53/PRKCA/EGFR/MAPK1/EGF/RB1/RAF1/E2F1/E2F2/CDK4/MDM2,15
hsa05235,PD-L1 expression and PD-1 checkpoint pathway in cancer,16/152,89/8063,6.23E-12,4.07E-11,1.56E-11,MAPK14/RELA/AKT1/JUN/EGFR/FOS/MAPK1/EGF/NFKBIA/RAF1/HIF1A/STAT1/IFNG/CHUK/IKBKB/PPP3CA,16
hsa01521,EGFR tyrosine kinase inhibitor resistance,15/152,79/8063,1.29E-11,8.21E-11,3.15E-11,AKT1/BCL2/BAX/KDR/IL6R/PRKCA/EGFR/VEGFA/BCL2L1/MAPK1/EGF/RAF1/ERBB2/ERBB3/MET,15
hsa04064,NF-kappa B signaling pathway,16/152,104/8063,7.35E-11,4.46E-10,1.71E-10,PTGS2/RELA/BCL2/CXCL8/PLAU/BCL2L1/NFKBIA/ICAM1/IL1B/VCAM1/PARP1/CXCL2/CHUK/CD40LG/XIAP/IKBKB,16
hsa04660,T cell receptor signaling pathway,16/152,104/8063,7.35E-11,4.46E-10,1.71E-10,MAPK14/RELA/AKT1/JUN/IL4/FOS/MAPK1/NFKBIA/RAF1/IFNG/CHUK/CD40LG/CDK4/IKBKB/MAPK8/PPP3CA,16
hsa05165,Human papillomavirus infection,27/152,331/8063,7.69E-11,4.56E-10,1.75E-10,PTGS2/CDK2/RELA/AKT1/CCND1/CDKN1A/BAX/CASP3/TP53/FN1/CASP8/CCNA2/EGFR/VEGFA/MAPK1/EGF/RB1/RAF1/STAT1/COL1A1/CHUK/SPP1/E2F1/IRF1/CDK4/MDM2/IKBKB,27
hsa05206,MicroRNAs in cancer,26/152,310/8063,9.78E-11,5.59E-10,2.15E-10,PTGS2/CCND1/BCL2/CDKN1A/CASP3/TP53/MCL1/PRKCA/PLAU/MMP9/EGFR/VEGFA/MAPK1/RAF1/ERBB2/HMOX1/MYC/CYP1B1/RASSF1/E2F1/E2F2/ERBB3/CD44/MDM2/MET/IKBKB,26
hsa05133,Pertussis,14/152,76/8063,9.86E-11,5.59E-10,2.15E-10,NOS2/MAPK14/RELA/JUN/CASP3/CXCL8/FOS/MAPK1/IL1B/IL1A/IRF1/CASP7/MAPK8/CASP1,14
hsa05140,Leishmaniasis,14/152,77/8063,1.19E-10,6.57E-10,2.52E-10,NOS2/PTGS2/MAPK14/RELA/JUN/IL4/FOS/MAPK1/NFKBIA/STAT1/IL1B/IFNG/IL1A/NCF1,14
hsa04215,Apoptosis - multiple species,10/152,32/8063,1.90E-10,1.03E-09,3.97E-10,BCL2/BAX/CASP9/CASP3/CASP8/BCL2L1/BIRC5/CASP7/XIAP/MAPK8,10
hsa04380,Osteoclast differentiation,17/152,128/8063,2.00E-10,1.06E-09,4.08E-10,PPARG/MAPK14/RELA/AKT1/JUN/FOS/MAPK1/NFKBIA/STAT1/IL1B/IFNG/IL1A/NCF1/CHUK/IKBKB/MAPK8/PPP3CA,17
hsa05226,Gastric cancer,18/152,149/8063,2.80E-10,1.46E-09,5.59E-10,RXRA/CDK2/AKT1/CCND1/BCL2/CDKN1A/BAX/TP53/EGFR/MAPK1/EGF/RB1/RAF1/ERBB2/MYC/E2F1/E2F2/MET,18
hsa05132,Salmonella infection,21/152,213/8063,3.91E-10,2.00E-09,7.66E-10,MAPK14/RELA/AKT1/BCL2/BAX/JUN/CASP3/CXCL8/CASP8/FOS/MAPK1/NFKBIA/RAF1/MYC/IL1B/CHUK/CASP7/IKBKB/MAPK8/CASP1/MAP2K4,21
hsa05120,Epithelial cell signaling in Helicobacter pylori infection,13/152,70/8063,4.27E-10,2.13E-09,8.20E-10,MAPK14/RELA/JUN/CASP3/CXCL8/EGFR/NFKBIA/CXCL2/CHUK/MET/IKBKB/MAPK8/MAP2K4,13
hsa05213,Endometrial cancer,12/152,58/8063,5.51E-10,2.70E-09,1.04E-09,AKT1/CCND1/CDKN1A/BAX/CASP9/TP53/EGFR/MAPK1/EGF/RAF1/ERBB2/MYC,12
hsa04370,VEGF signaling pathway,12/152,59/8063,6.80E-10,3.27E-09,1.26E-09,PTGS2/MAPK14/AKT1/CASP9/KDR/PRKCA/VEGFA/MAPK1/RAF1/NOS3/HSPB1/PPP3CA,12
hsa05152,Tuberculosis,19/152,180/8063,9.02E-10,4.26E-09,1.63E-09,NOS2/MAPK14/RELA/AKT1/BCL2/BAX/CASP9/CASP3/CASP8/MAPK1/IL10RA/RAF1/STAT1/IL1B/IFNG/IL1A/CTSD/MAPK8/PPP3CA,19
hsa04658,Th1 and Th2 cell differentiation,14/152,92/8063,1.40E-09,6.47E-09,2.48E-09,MAPK14/RELA/JUN/IL4/FOS/MAPK1/NFKBIA/STAT1/IL2RA/IFNG/CHUK/IKBKB/MAPK8/PPP3CA,14
hsa05135,Yersinia infection,16/152,130/8063,2.21E-09,1.01E-08,3.87E-09,MAPK14/RELA/AKT1/JUN/CCL2/FN1/CXCL8/FOS/MAPK1/NFKBIA/IL1B/CHUK/IKBKB/MAPK8/CASP1/MAP2K4,16
hsa05170,Human immunodeficiency virus 1 infection,20/152,212/8063,2.32E-09,1.04E-08,3.98E-09,MAPK14/RELA/AKT1/BCL2/BAX/CASP9/JUN/CASP3/CASP8/PRKCA/BCL2L1/FOS/MAPK1/NFKBIA/RAF1/CCNB1/CHUK/IKBKB/MAPK8/PPP3CA,20
hsa04068,FoxO signaling pathway,16/152,131/8063,2.48E-09,1.09E-08,4.19E-09,MAPK14/CDK2/AKT1/CCND1/CDKN1A/EGFR/MAPK1/EGF/RAF1/CCNB1/SLC2A4/CHUK/MDM2/IKBKB/MAPK8/CAT,16
hsa05202,Transcriptional misregulation in cancer,19/152,192/8063,2.70E-09,1.17E-08,4.48E-09,PPARG/RXRA/RELA/CDKN1A/BAX/TP53/CXCL8/PLAU/CCNA2/MMP9/MMP3/BCL2L1/MYC/PLAT/MPO/RUNX2/IGFBP3/MDM2/MET,19
hsa04012,ErbB signaling pathway,13/152,85/8063,5.21E-09,2.22E-08,8.51E-09,AKT1/CDKN1A/JUN/PRKCA/EGFR/MAPK1/EGF/RAF1/ERBB2/MYC/ERBB3/MAPK8/MAP2K4,13
hsa04915,Estrogen signaling pathway,16/152,138/8063,5.36E-09,2.23E-08,8.54E-09,ESR1/AKT1/BCL2/JUN/PGR/OPRM1/ESR2/MMP2/MMP9/EGFR/FOS/MAPK1/RAF1/NOS3/CTSD/ADCY2,16
hsa04917,Prolactin signaling pathway,12/152,70/8063,5.41E-09,2.23E-08,8.54E-09,ESR1/MAPK14/RELA/AKT1/CCND1/ESR2/FOS/MAPK1/RAF1/STAT1/IRF1/MAPK8,12
hsa04510,Focal adhesion,19/152,201/8063,5.83E-09,2.36E-08,9.06E-09,AKT1/CCND1/BCL2/KDR/JUN/FN1/PRKCA/EGFR/VEGFA/MAPK1/EGF/RAF1/ERBB2/CAV1/COL1A1/SPP1/XIAP/MET/MAPK8,19
hsa04621,NOD-like receptor signaling pathway,18/152,181/8063,6.75E-09,2.69E-08,1.03E-08,MAPK14/RELA/BCL2/JUN/CCL2/CXCL8/CASP8/BCL2L1/MAPK1/NFKBIA/STAT1/IL1B/CXCL2/CHUK/XIAP/IKBKB/MAPK8/CASP1,18
hsa04932,Non-alcoholic fatty liver disease,16/152,150/8063,1.81E-08,7.09E-08,2.72E-08,RXRA/RELA/AKT1/BAX/JUN/IL6R/CASP3/CXCL8/CASP8/FOS/IL1B/IL1A/PPARA/CASP7/IKBKB/MAPK8,16
hsa05130,Pathogenic Escherichia coli infection,18/152,193/8063,1.87E-08,7.23E-08,2.77E-08,MAPK14/RELA/BAX/CASP9/JUN/CASP3/CXCL8/CASP8/FOS/MAPK1/NFKBIA/IL1B/CLDN4/CHUK/CASP7/IKBKB/MAPK8/CASP1,18
hsa05131,Shigellosis,20/152,242/8063,2.28E-08,8.66E-08,3.32E-08,MAPK14/RELA/AKT1/BCL2/BAX/JUN/TP53/CXCL8/EGFR/BCL2L1/MAPK1/NFKBIA/IL1B/CHUK/HK2/CD44/MDM2/IKBKB/MAPK8/CASP1,20
hsa05221,Acute myeloid leukemia,11/152,67/8063,3.86E-08,1.45E-07,5.55E-08,RELA/AKT1/CCND1/CCNA2/MAPK1/RAF1/MYC/MPO/PPARD/CHUK/IKBKB,11
hsa04630,JAK-STAT signaling pathway,16/152,162/8063,5.43E-08,2.01E-07,7.71E-08,AKT1/CCND1/BCL2/CDKN1A/IL6R/MCL1/IL4/EGFR/BCL2L1/IL10RA/EGF/RAF1/STAT1/MYC/IL2RA/IFNG,16
hsa05230,Central carbon metabolism in cancer,11/152,70/8063,6.19E-08,2.25E-07,8.65E-08,AKT1/TP53/EGFR/MAPK1/RAF1/HIF1A/ERBB2/MYC/HK2/MET/G6PD,11
hsa05134,Legionellosis,10/152,57/8063,8.52E-08,3.06E-07,1.17E-07,RELA/CASP9/CASP3/CXCL8/CASP8/NFKBIA/IL1B/CXCL2/CASP7/CASP1,10
hsa05323,Rheumatoid arthritis,12/152,93/8063,1.46E-07,5.17E-07,1.99E-07,JUN/MMP1/CCL2/CXCL8/MMP3/VEGFA/FOS/ICAM1/IL1B/IFNG/IL1A/CXCL2,12
hsa05144,Malaria,9/152,50/8063,3.07E-07,1.07E-06,4.12E-07,CCL2/CXCL8/ICAM1/IL1B/SELE/VCAM1/IFNG/CD40LG/MET,9
hsa05216,Thyroid cancer,8/152,37/8063,3.22E-07,1.11E-06,4.26E-07,PPARG/RXRA/CCND1/CDKN1A/BAX/TP53/MAPK1/MYC,8
hsa04919,Thyroid hormone signaling pathway,13/152,121/8063,3.86E-07,1.31E-06,5.04E-07,ESR1/RXRA/AKT1/CCND1/CASP9/TP53/PRKCA/MAPK1/RAF1/HIF1A/STAT1/MYC/MDM2,13
hsa04110,Cell cycle,13/152,124/8063,5.15E-07,1.73E-06,6.63E-07,CDK2/CCND1/CDKN1A/TP53/CCNA2/RB1/MYC/CCNB1/CHEK2/E2F1/E2F2/CDK4/MDM2,13
hsa04071,Sphingolipid signaling pathway,12/152,119/8063,2.18E-06,7.14E-06,2.74E-06,MAPK14/RELA/AKT1/BCL2/BAX/TP53/PRKCA/MAPK1/RAF1/NOS3/CTSD/MAPK8,12
hsa04722,Neurotrophin signaling pathway,12/152,119/8063,2.18E-06,7.14E-06,2.74E-06,MAPK14/RELA/AKT1/BCL2/BAX/JUN/TP53/MAPK1/NFKBIA/RAF1/IKBKB/MAPK8,12
hsa04662,B cell receptor signaling pathway,10/152,82/8063,2.82E-06,9.10E-06,3.49E-06,RELA/AKT1/JUN/FOS/MAPK1/NFKBIA/RAF1/CHUK/IKBKB/PPP3CA,10
hsa04062,Chemokine signaling pathway,15/152,192/8063,2.98E-06,9.48E-06,3.64E-06,RELA/AKT1/CCL2/CXCL8/MAPK1/NFKBIA/RAF1/STAT1/NCF1/CXCL11/CXCL2/CXCL10/CHUK/ADCY2/IKBKB,15
hsa05146,Amoebiasis,11/152,102/8063,3.04E-06,9.56E-06,3.67E-06,NOS2/RELA/CASP3/FN1/CXCL8/PRKCA/IL1B/HSPB1/COL1A1/IFNG/CXCL2,11
hsa04664,Fc epsilon RI signaling pathway,9/152,68/8063,4.53E-06,1.41E-05,5.41E-06,MAPK14/AKT1/PRKCA/IL4/MAPK1/RAF1/ALOX5/MAPK8/MAP2K4,9
hsa04920,Adipocytokine signaling pathway,9/152,69/8063,5.12E-06,1.57E-05,6.04E-06,RXRA/RELA/AKT1/NFKBIA/SLC2A4/PPARA/CHUK/IKBKB/MAPK8,9
hsa04622,RIG-I-like receptor signaling pathway,9/152,70/8063,5.79E-06,1.76E-05,6.74E-06,MAPK14/RELA/CXCL8/CASP8/NFKBIA/CXCL10/CHUK/IKBKB/MAPK8,9
hsa05203,Viral carcinogenesis,15/152,204/8063,6.29E-06,1.89E-05,7.25E-06,CDK2/RELA/CCND1/CDKN1A/BAX/JUN/CASP3/TP53/CASP8/CCNA2/MAPK1/RB1/NFKBIA/CDK4/MDM2,15
hsa04014,Ras signaling pathway,16/152,232/8063,6.94E-06,2.06E-05,7.90E-06,RELA/AKT1/KDR/PRKCA/EGFR/VEGFA/BCL2L1/MAPK1/EGF/RAF1/CHUK/RASSF1/IGF2/MET/IKBKB/MAPK8,16
hsa04912,GnRH signaling pathway,10/152,93/8063,8.92E-06,2.61E-05,1.00E-05,MAPK14/JUN/PRKCA/MMP2/EGFR/MAPK1/RAF1/ADCY2/MAPK8/MAP2K4,10
hsa04726,Serotonergic synapse,11/152,115/8063,9.83E-06,2.85E-05,1.09E-05,PTGS1/PTGS2/CASP3/SLC6A4/PRKCA/MAOA/HTR3A/MAPK1/RAF1/ALOX5/APP,11
hsa04935,"Growth hormone synthesis, secretion and action",11/152,119/8063,1.37E-05,3.91E-05,1.50E-05,MAPK14/AKT1/PRKCA/FOS/MAPK1/RAF1/STAT1/IGFBP3/ADCY2/MAPK8/MAP2K4,11
hsa05231,Choline metabolism in cancer,10/152,98/8063,1.43E-05,4.04E-05,1.55E-05,AKT1/JUN/PRKCA/EGFR/FOS/MAPK1/EGF/RAF1/HIF1A/MAPK8,10
hsa04914,Progesterone-mediated oocyte maturation,10/152,99/8063,1.56E-05,4.37E-05,1.68E-05,MAPK14/CDK2/AKT1/PGR/CCNA2/MAPK1/RAF1/CCNB1/ADCY2/MAPK8,10
hsa00140,Steroid hormone biosynthesis,8/152,61/8063,1.68E-05,4.65E-05,1.78E-05,CYP3A4/CYP1A2/CYP1A1/SULT1E1/CYP1B1/HSD3B2/HSD3B1/UGT1A1,8
hsa04928,"Parathyroid hormone synthesis, secretion and action",10/152,106/8063,2.85E-05,7.82E-05,3.00E-05,RXRA/BCL2/CDKN1A/PRKCA/EGFR/FOS/MAPK1/RAF1/RUNX2/ADCY2,10
hsa04921,Oxytocin signaling pathway,12/152,154/8063,3.12E-05,8.48E-05,3.25E-05,PTGS2/CCND1/CDKN1A/JUN/PRKCA/EGFR/FOS/MAPK1/RAF1/NOS3/ADCY2/PPP3CA,12
hsa04934,Cushing syndrome,12/152,155/8063,3.33E-05,8.95E-05,3.43E-05,CDK2/CCND1/CDKN1A/EGFR/MAPK1/RB1/E2F1/E2F2/HSD3B2/HSD3B1/CDK4/ADCY2,12
hsa05211,Renal cell carcinoma,8/152,69/8063,4.19E-05,0.000111288,4.27E-05,AKT1/CDKN1A/JUN/VEGFA/MAPK1/RAF1/HIF1A/MET,8
hsa04913,Ovarian steroidogenesis,7/152,51/8063,4.26E-05,0.000111879,4.30E-05,PTGS2/CYP1A1/CYP1B1/ALOX5/HSD3B2/HSD3B1/ADCY2,7
hsa04024,cAMP signaling pathway,14/152,216/8063,5.33E-05,0.000138773,5.33E-05,ADRB2/RELA/AKT1/JUN/CHRM1/ADRB1/FOS/MAPK1/NFKBIA/RAF1/PPARA/ADCY2/ACOX1/MAPK8,14
hsa05143,African trypanosomiasis,6/152,37/8063,5.83E-05,0.000150237,5.77E-05,PRKCA/ICAM1/IL1B/SELE/VCAM1/IFNG,6
hsa05010,Alzheimer disease,19/152,369/8063,6.01E-05,0.000153214,5.88E-05,NOS2/PTGS2/RELA/AKT1/CASP9/CASP3/CHRM3/CHRM1/CASP8/MAPK1/RAF1/IL1B/IL1A/CHUK/APP/CASP7/IKBKB/MAPK8/PPP3CA,19
hsa00980,Metabolism of xenobiotics by cytochrome P450,8/152,77/8063,9.28E-05,0.000234399,9.00E-05,CYP3A4/CYP1A2/CYP2B6/CYP1A1/CYP1B1/GSTP1/GSTM1/UGT1A1,8
hsa04020,Calcium signaling pathway,13/152,201/8063,0.000101752,0.000254381,9.77E-05,NOS2/ADRB2/CHRM3/CHRM1/PRKCA/ADRB1/EGFR/EGF/ERBB2/NOS3/ERBB3/ADCY2/PPP3CA,13
hsa00380,Tryptophan metabolism,6/152,42/8063,0.000121781,0.000301496,0.000115745,MAOA/CYP1A2/CYP1A1/CYP1B1/EHHADH/CAT,6
hsa05416,Viral myocarditis,7/152,60/8063,0.000123206,0.000302091,0.000115973,CCND1/CASP9/CASP3/CASP8/CAV1/ICAM1/CD40LG,7
hsa05204,Chemical carcinogenesis,8/152,82/8063,0.000145246,0.000352739,0.000135417,PTGS2/CYP3A4/CYP1A2/CYP1A1/CYP1B1/GSTP1/GSTM1/UGT1A1,8
hsa04623,Cytosolic DNA-sensing pathway,7/152,63/8063,0.000168366,0.00040503,0.000155492,RELA/NFKBIA/IL1B/CXCL10/CHUK/IKBKB/CASP1,7
hsa04217,Necroptosis,11/152,159/8063,0.000196123,0.000467395,0.000179433,BCL2/BAX/CASP8/STAT1/IL1B/IFNG/IL1A/PARP1/XIAP/MAPK8/CASP1,11
hsa05321,Inflammatory bowel disease,7/152,65/8063,0.000205299,0.000484734,0.00018609,RELA/JUN/IL4/STAT1/IL1B/IFNG/IL1A,7
hsa04540,Gap junction,8/152,88/8063,0.000238141,0.000557119,0.000213879,PRKCA/ADRB1/EGFR/MAPK1/EGF/RAF1/GJA1/ADCY2,8
hsa04371,Apelin signaling pathway,10/152,137/8063,0.000249361,0.000578064,0.000221919,NOS2/AKT1/CCND1/MAPK1/RAF1/NOS3/PLAT/SERPINE1/SPP1/ADCY2,10
hsa01523,Antifolate resistance,5/152,31/8063,0.000254928,0.000585645,0.00022483,RELA/IL1B/ABCG2/CHUK/IKBKB,5
hsa04725,Cholinergic synapse,9/152,113/8063,0.000266829,0.000607513,0.000233225,AKT1/BCL2/CHRM3/CHRM1/ACHE/PRKCA/FOS/MAPK1/ADCY2,9
hsa04137,Mitophagy - animal,7/152,68/8063,0.000272714,0.000615417,0.000236259,RELA/JUN/TP53/BCL2L1/HIF1A/E2F1/MAPK8,7
hsa04022,cGMP-PKG signaling pathway,11/152,167/8063,0.000300994,0.000673275,0.000258471,ADRB2/AKT1/ADRA2A/ADRB1/ADRA2C/ADRA2B/MAPK1/RAF1/NOS3/ADCY2/PPP3CA,11
hsa00982,Drug metabolism - cytochrome P450,7/152,71/8063,0.000356894,0.000791374,0.000303809,MAOA/CYP3A4/CYP1A2/CYP2B6/GSTP1/GSTM1/UGT1A1,7
hsa04061,Viral protein interaction with cytokine and cytokine receptor,8/152,100/8063,0.000569999,0.001253015,0.000481034,IL6R/CCL2/CXCL8/IL10RA/IL2RA/CXCL11/CXCL2/CXCL10,8
hsa03320,PPAR signaling pathway,7/152,77/8063,0.000587379,0.001280184,0.000491464,PPARG/RXRA/MMP1/PPARA/PPARD/ACOX1/EHHADH,7
hsa04923,Regulation of lipolysis in adipocytes,6/152,56/8063,0.000606805,0.001311317,0.000503416,PTGS1/PTGS2/ADRB2/AKT1/ADRB1/ADCY2,6
hsa04931,Insulin resistance,8/152,108/8063,0.000950025,0.002035767,0.000781533,RELA/AKT1/NFKBIA/NOS3/SLC2A4/PPARA/IKBKB/MAPK8,8
hsa04929,GnRH secretion,6/152,64/8063,0.001238372,0.00263154,0.001010251,AKT1/PRKCA/ESR2/MAPK1/RAF1/SPP1,6
hsa04670,Leukocyte transendothelial migration,8/152,114/8063,0.001350803,0.002846734,0.001092864,MAPK14/PRKCA/MMP2/MMP9/ICAM1/VCAM1/NCF1/CLDN4,8
hsa04211,Longevity regulating pathway,7/152,89/8063,0.001394633,0.002915011,0.001119075,PPARG/RELA/AKT1/BAX/TP53/ADCY2/CAT,7
hsa04930,Type II diabetes mellitus,5/152,46/8063,0.001638932,0.003397786,0.001304413,MAPK1/SLC2A4/HK2/IKBKB/MAPK8,5
hsa05031,Amphetamine addiction,6/152,69/8063,0.001833197,0.003769882,0.001447261,JUN/SLC6A3/PRKCA/MAOA/FOS/PPP3CA,6
hsa05020,Prion disease,13/152,273/8063,0.001888793,0.003853137,0.001479223,MAPK14/BAX/CASP9/CASP3/MAPK1/SOD1/HSPA5/CAV1/IL1B/IL1A/NCF1/MAPK8/PPP3CA,13
hsa04261,Adrenergic signaling in cardiomyocytes,9/152,149/8063,0.001963047,0.003972834,0.001525175,SCN5A/MAPK14/ADRB2/AKT1/BCL2/PRKCA/ADRB1/MAPK1/ADCY2,9
hsa04015,Rap1 signaling pathway,11/152,210/8063,0.00200907,0.004033959,0.001548641,MAPK14/AKT1/KDR/PRKCA/EGFR/VEGFA/MAPK1/EGF/RAF1/ADCY2/MET,11
hsa04114,Oocyte meiosis,8/152,128/8063,0.002813478,0.005604976,0.002151756,AR/MAPK14/CDK2/PGR/MAPK1/CCNB1/ADCY2/PPP3CA,8
hsa04728,Dopaminergic synapse,8/152,132/8063,0.00340233,0.006725535,0.002581939,MAPK14/AKT1/SLC6A3/PRKCA/MAOA/FOS/MAPK8/PPP3CA,8
hsa04060,Cytokine-cytokine receptor interaction,13/152,294/8063,0.003600536,0.00706259,0.002711335,IL6R/CCL2/CXCL8/IL4/IL10RA/IL1B/IL2RA/IFNG/IL1A/CXCL11/CXCL2/CXCL10/CD40LG,13
hsa04140,Autophagy - animal,8/152,137/8063,0.004268294,0.008308511,0.003189645,AKT1/BCL2/BCL2L1/MAPK1/RAF1/HIF1A/CTSD/MAPK8,8
hsa04610,Complement and coagulation cascades,6/152,85/8063,0.005230694,0.01010475,0.003879223,PLAU/F7/F3/PLAT/THBD/SERPINE1,6
hsa00590,Arachidonic acid metabolism,5/152,63/8063,0.006508492,0.012478688,0.00479058,PTGS1/PTGS2/LTA4H/CYP2B6/ALOX5,5
hsa04072,Phospholipase D signaling pathway,8/152,148/8063,0.006765912,0.01287543,0.00494289,AKT1/CXCL8/PRKCA/EGFR/MAPK1/EGF/RAF1/ADCY2,8
hsa04976,Bile secretion,6/152,90/8063,0.006897653,0.0130289,0.005001807,RXRA/CA2/CYP3A4/ABCG2/ADCY2/UGT1A1,6
hsa04611,Platelet activation,7/152,124/8063,0.008833691,0.01656317,0.006358616,PTGS1/MAPK14/AKT1/MAPK1/NOS3/COL1A1/ADCY2,7
hsa00830,Retinol metabolism,5/152,68/8063,0.008956624,0.016671089,0.006400046,CYP3A4/CYP1A2/CYP2B6/CYP1A1/UGT1A1,5
hsa04310,Wnt signaling pathway,8/152,160/8063,0.01061288,0.019610756,0.007528588,CCND1/JUN/TP53/PRKCA/MYC/PPARD/MAPK8/PPP3CA,8
hsa04640,Hematopoietic cell lineage,6/152,99/8063,0.010819492,0.019848709,0.007619938,IL6R/IL4/IL1B/IL2RA/IL1A/CD44,6
hsa04650,Natural killer cell mediated cytotoxicity,7/152,131/8063,0.01175077,0.021403188,0.008216704,CASP3/PRKCA/MAPK1/RAF1/ICAM1/IFNG/PPP3CA,7
hsa05030,Cocaine addiction,4/152,49/8063,0.013329106,0.02410583,0.009254251,RELA/JUN/SLC6A3/MAOA,4
hsa00330,Arginine and proline metabolism,4/152,50/8063,0.014280766,0.025645037,0.009845154,NOS2/MAOA/ODC1/NOS3,4
hsa04910,Insulin signaling pathway,7/152,137/8063,0.014759459,0.026319315,0.010104009,AKT1/MAPK1/RAF1/SLC2A4/HK2/IKBKB/MAPK8,7
hsa00983,Drug metabolism - other enzymes,5/152,79/8063,0.016435844,0.02910514,0.01117349,CYP3A4/MPO/GSTP1/GSTM1/UGT1A1,5
hsa05012,Parkinson disease,10/152,249/8063,0.019122152,0.033628612,0.012910055,BAX/CASP9/CASP3/TP53/SLC6A3/MAOA/BCL2L1/HSPA5/NFE2L2/MAPK8,10
hsa05014,Amyotrophic lateral sclerosis,13/152,364/8063,0.019727445,0.034455468,0.013227486,NOS2/MAPK14/BCL2/BAX/CASP9/CASP3/TP53/BCL2L1/SOD1/HSPA5/PPP3CA/CAT/CASP1,13
hsa04146,Peroxisome,5/152,83/8063,0.019952316,0.03461116,0.013287256,NOS2/SOD1/ACOX1/EHHADH/CAT,5
hsa00480,Glutathione metabolism,4/152,57/8063,0.022148696,0.038161604,0.014650275,ODC1/GSTP1/GSTM1/G6PD,4
hsa05168,Herpes simplex virus 1 infection,16/152,491/8063,0.022336731,0.038227291,0.014675493,RELA/AKT1/BCL2/BAX/CASP9/CASP3/TP53/CCL2/CASP8/BCL2L1/NFKBIA/STAT1/IL1B/IFNG/CHUK/IKBKB,16
hsa04213,Longevity regulating pathway - multiple species,4/152,62/8063,0.02911733,0.049499461,0.019002889,AKT1/SOD1/ADCY2/CAT,4
hsa04666,Fc gamma R-mediated phagocytosis,5/152,93/8063,0.030800162,0.051671324,0.019836669,AKT1/PRKCA/MAPK1/RAF1/NCF1,5
hsa04970,Salivary secretion,5/152,93/8063,0.030800162,0.051671324,0.019836669,ADRB2/CHRM3/PRKCA/ADRB1/ADCY2,5
hsa05330,Allograft rejection,3/152,38/8063,0.034251325,0.057085542,0.021915192,IL4/IFNG/CD40LG,3
hsa04720,Long-term potentiation,4/152,67/8063,0.037251435,0.061682572,0.023679997,PRKCA/MAPK1/RAF1/PPP3CA,4
hsa04750,Inflammatory mediator regulation of TRP channels,5/152,100/8063,0.040244234,0.066208256,0.025417411,MAPK14/PRKCA/IL1B/ADCY2/MAPK8,5
hsa04916,Melanogenesis,5/152,101/8063,0.04172208,0.068199554,0.026181872,PRKCA/MAPK1/RAF1/TYR/ADCY2,5
hsa04972,Pancreatic secretion,5/152,102/8063,0.043232458,0.070218323,0.026956879,PRSS1/CHRM3/PRKCA/CA2/ADCY2,5
hsa05332,Graft-versus-host disease,3/152,42/8063,0.044160037,0.071270946,0.027360982,IL1B/IFNG/IL1A,3
hsa04520,Adherens junction,4/152,71/8063,0.044609419,0.071543408,0.027465581,EGFR/MAPK1/ERBB2/MET,4
hsa04940,Type I diabetes mellitus,3/152,43/8063,0.046837023,0.074646505,0.028656863,IL1B/IFNG/IL1A,3
hsa04810,Regulation of actin cytoskeleton,8/152,214/8063,0.049083487,0.077740927,0.029844814,FN1/CHRM3/CHRM1/EGFR/MAPK1/EGF/RAF1/INSRR,8
hsa00071,Fatty acid degradation,3/152,44/8063,0.049592433,0.078062163,0.029968137,ACOX1/EHHADH/HADHB,3