>AacCas12b1
SMAVKSIKVKLRLDDMPEIRAGLWKLHKEVNAGVRYYTEWLSLLRQENLYRRSPNGDGEQECDKTAEECKAELLERLRAR
QVENGHRGPAGSDDELLQLARQLYELLVPQAIGAKGDAQQIARKFLSPLADKDAVGGLGIAKAGNKPRWVRMREAGEPGW
EEEKEKAETRKSADRTADVLRALADFGLKPLMRVYTDSEMSSVEWKPLRKGQAVRTWDRDMFQQAIERMMSWESWNQRVG
QEYAKLVEQKNRFEQKNFVGQEHLVHLVNQLQQDMKEASPGLESKEQTAHYVTGRALRGSDKVFEKWGKLAPDAPFDLYD
AEIKNVQRRNTRRFGSHDLFAKLAEPEYQALWREDASFLTRYAVYNSILRKLNHAKMFATFTLPDATAHPIWTRFDKLGG
NLHQYTFLFNEFGERRHAIRFHKLLKVENGVAREVDDVTVPISMSEQLDNLLPRDPNEPIALYFRDYGAEQHFTGEFGGA
KIQCRRDQLAHMHRRRGARDVYLNVSVRVQSQSEARGERRPPYAAVFRLVGDNHRAFVHFDKLSDYLAEHPDDGKLGSEG
LLSGLRVMSVALGLRTSASISVFRVARKDELKPNSKGRVPFFFPIKGNDNLVAVHERSQLLKLPGETESKDLRAIREERQ
RTLRQLRTQLAYLRLLVRCGSEDVGRRERSWAKLIEQPVDAANHMTPDWREAFENELQKLKSLHGICSDKEWMDAVYESV
RRVWRHMGKQVRDWRKDVRSGERPKIRGYAKDVVGGNSIEQIEYLERQYKFLKSWSFFGKVSGQVIRAEKGSRFAITLRE
HIDHAKEDRLKKLADRIIMEALGYVYALDERGKGKWVAKYPPCQLILLAELSEYQFNNDRPPSENNQLMQWSHRGVFQEL
INQAQVHDLLVGTMYAAFSSRFDARTGAPGIRCRRVPARCTQEHNPEPFPWWLNKFVVEHTLDACPLRADDLIPTGEGEI
FVSPFSAEEGDFHQIHAALNAAQNLQQRLWSDFDISQIRLRCDWGEVDGELVLIPRLTGKRTADSYSNKVFYTNTGVTYY
ERERGKKRRKVFAQEKLSEEEAELLVEADEAREKSVVLMRDPSGIINRGNWTRQKEFWSMVNQRIEGYLVKQIRSRVPLQ
DSACENTGDI
>AbCas12a
MKSDFFAPFTNLYPIQKTLRRELKPLNENFQHDPALTALRNSEIPQRDQQREKDYQAIKPLLDELHNQFITESLQSLETQ
DRSDFVLFYQTYQKKKKNKADFSEKELKSLDEEFESRTKSLRTAIGNSYAKLAELRKSNPDYVNEKGKPFLDQKSYKILT
EAGVLGLLEKKYASDLEKLALIRRFGNFFTYFTGFNQNRENYYTTDEKATAVAYRAINENLLTFANNCELFEKLAVLGLS
ELEKKIFNPDSYSEYLTQSGIDFYNEMLANIRSKANLYTQEHKTKLPQPKLLYKQIGSPRGNTIPFDLINNDEEFKKMLH
TMIAETDQRIPEFNKLLESIFEENADLSQIFLSKTSLNIISNRYFSSWNTLLEKGVELKLFKFKKNDEESFKLPTYLSLA
ELKELLEAVPFQTAEKSDTAEGTHHQVSLLKLQRENLHLESSHSNWELLLKSMKSDFESFWTGEGEFGSYTSAKKALQSL
SSLQSTNQEHKNLIKMLLDNTLYAYRMLKWFKVDTSKLGFVPEGEFYPSLDQLLQDYPLPKWYDMIRNYLTRKPYSQAKL
KLNFDCSTLLNGRDKNKETQNLSVILRKDGKFYLAIMKKDQNKFFEKSALYEGNLGTMEKMDYKLLPGANKMLPKCLMPG
SDKKKYGASDQVLELYAKGSFKKSEKSFNLADLHTLIDFYKSALPKYEDWKVFNFQFQATENYQDISQFYREVEQQGYLL
NRRKVNEELIKQGIKDGSLFLFQISSKDFEGKSKTPDLQTLYWCQLFESPTNVKLNGEAEIFFRLGSMKKEKKTLKVDNY
DVFKHKRYTEDKILFHVPITLGFGNNEVSASAPSKFNQKLNQELIIPHFDDLHVIGVDRGEKHLAFYSVVSVKTGKIVKQ
GTLNLLNGTDYEAKLSQKAENRLHARQNRDTIEKIADLKNGYISQVVNKLVELVLEYNAVIVFEDLNAGFKRGRQKIEQS
VYQKLELALAKKLNFIVKKEKAVVEPGSVTSAYQLAPQINTFGDIKGKQRGIMLYTRANYTSVTDPLTGRRKQYYFKKGS
SEEMKAQFFKSFKNLTRDAGQKAYIFDDGTWQLYSNVERRRGKRGDHRERTQIKYDPSLELDTLFSKYQIEKSDSLLDQL
KNRDLPQTFWTSFFRILDLIMQIRNTDDEGRDIILSPIGNAQERFDSRKRYDQLPRDEKGVVIEESAFEYPTSGDANGAY
NIARKGVMMLERIKENTEKPDLLIRDAEWDKKITN
>AbCas12a2
MVNLESFKNLYEVRKTVRFGLNQPNKKSNINKTHGQLKDLVDLSFEREKKLINNEKNQVLIDSEKALIEKLQQYVNGLEV
QLENWEGTYQRYDLIAINKDYYKILARKAKFDAMWEISKFDKKSNKYIKVKQPQASQISLSSLKIGNRSDSIIQYWGEII
EKTDYLLNIFKPKLEQYERAINDANSTHIKPDSIDFRKIFLQLLKLTKEFLQPLLDRSIIFEFSKKKVSQEIEKISEFAG
EKNNTKIYNVLKNGEELRQYFEANGSQVPYGRVSLNYYTAVQKPNNFDQEIKKAIDDLGIINFLKKRDSQIIDYLHQGSK
QKIKLLLTSKSPYSIELLQLFKVKPIPFSVKYNLAKFIEKNYKNEINLSYEEILDKLNLLGRAIDIANDFKNSNNQNNFS
LDEYPVKLAFDYAWENTARSLKRTIPFPKEVCKQFLKDNFDVDVNVDNADFKLYANLLFIADNLATIEYNNPNNEAELIN
EIKQVFDSIDFSFDKERYGGYKNDVLVLLNKAKPQRDYSTILKAKQELGLLRGGLKNKIKKYRDLTQRLIDKKDSHFGIA
SFVGKTLAKIRDRLKEENELNKISHYGVILEDKNQDKYLLISQLDGKDTREKISQKFGNGDIKVYQVNSFTSKALNKFIK
NPLSEDAKKFHGDFRYKHKEVSIYDEKGKWTGYQESFLSHIKKCLIDSEISREQNWEAFGWNFAGCNTYEEIEKEVDSKG
YQLTENFISIGNLESLEKDEGCLLFPIINQDISSQKQENKNIFTLDLEKVFEGKECRIHPEFSIFYRKPMEEHKKENKSG
IINRFGRLQLLANLGIEFIPRNSSFKTKKEQNRIAIDQKKQNQLVQEFNQEKVNTYFEGLDNYYIFGIDRGIKQLATLCI
TNKNGVIQDFDIYTKHFNSESKKWEYKFHRKDGILDLTNLKIESDKSGNKYIVDISLFQAKDEDGNPTGTNKQNIQLKKL
AYIRKLQYQMSANEEGVLSFLEKYKNKEEREQNMKELITPYKEGKNFVDLPMDIFQEMFENYYRLKTDQNLSESEKKNLM
KITTELDASESLKKGVVANMIGVIYYLMKKYEYKVKISLEDLSNAWFFSKDGLSGDVVLNTKNDGTMDLKKQDNLALAGV
GTYHFFEMQLLKKLFKISTEEGILHLVPSFGSVKNYTEIFKDKGKYVYKQFGIVYFVDPRNTSKKCPVCLNTQTTGKKEG
IPIINRNYKKSNIFYCERCGFQSIHSHCQEENIKDSNGFHYSVEEVERIEMKNKEAIEKYKKQGKNLHFIKNGDDNGAYN
IGEKIRELPKKSDVKNT
>AheCas12b1
MTVRSIRVKLAVGSPQYRDVRRGLWKTHEIMNQGVRYYCEWLVLMRQEPIYDEDEHGLTVVQRTREDIQAELLSRLRTLQ
SAHQHSGDMGTDEELLSLMRQLYEQLVPSSVDKNKSGDARMIARNFFNPLTNPNSQGGLGISNAGRKPKWLLKKLSGDPT
WEEDYKKAMEQKQESSVSFLLLELRRFGLHPIFLPYTDTVLEVSWAPKKARQWVRKWDYDLFQQSIERMLSWESWTRRVK
ERFEKLVESEKKFYDENFATDPEFIKLAETLEGELQASSQGFVAVDEHAFQIRPRSMRGFDRVADEWCKLADDAPIEEYE
AAIKRVQARLGRNFGSYVLFAHLAKPEYWSLWRSDPTKILRFARLRALQRAVARAKRHARLTLPDAIHHPIWIRYDAKGK
NIYSYRLLIPEKRSKRYYVEFSSLIMPDGENRWAEHRNIRVPLAFSRQWERLHFSIMEDGSLCVQYRDPGVDEPLRAELG
GAKIQFDRRYLIRRSSTLSAGECGPVYLNVSVDVNPAHRPDVQVLQSAKLVSVSRDTNRIYLRPENLSAYWKSQGDGTLP
LRVMSVDLGVRSSAAVVICRLEHRDSVVSSGRRTATIYRIAGTDEFVAVQERAFLLRLPGEGKGTNEDAPLRDVYAQLGT
IRQGIQILRSLLRLCDTKTPDERQEALHGLAQSLEPSGAWKDELHPHLVMLQGVVHDSVDNWKQKVISVHRQMERILGHA
VREWKVARKNAGKPPIRRGAGGLSLRRIRQLEQERRTLVAWSNHAREPGQVVRIKRGTQVAQWLVERVNHLKEDRLKKLA
DLLIMTALGYVYDETKPSGHKWDKRYPPCQIILMEDLSRYRFQSDRPPSENSQLMAWSHRRLLEILKLQADLHKLIVGTV
FPAFSSRFDAQSGAPGVRCRSVKKQDIENAAQGKGWLARELQRLNWTLEWLQPNDLIPTGDGELFVTPACCDRQKGIKIV
HADLNAAQNLQRRFWGGHAESLCRVTCDVVERDGRRYAVPRISNAFADSFYKVFGQGVFVSTDEEDVYRWMVGEKISSRG
RSRGRTSDEEAEAETWIDEAREQQGKVIALFRDASGQIHGGDWLVAKVFWGWVERLVTARLLSRMSEREAAAHKE
>AkaCas12b1
MAVKSIKVKLRLSECPDILAGMWQLHRATNAGVRYYTEWVSLMRQEILYSRGPDGGQQCYMTAEDCQRELLRRLRNRQLH
NGRQDQPGTDADLLAISRRLYEILVLQSIGKRGDAQQIASSFLSPLVDPNSKGGRGEAKSGRKPAWQKMRDQGDPRWVAA
REKYEQRKAVDPSKEILNSLDALGLRPLFAVFTETYRSGVDWKPLGKSQGVRTWDRDMFQQALERLMSWESWNRRVGEEY
ARLFQQKMKFEQEHFAEQSHLVKLARALEADMRAASQGFEAKRGTAHQITRRALRGADRVFEIWKSIPEEALFSQYDEVI
RQVQAEKRRDFGSHDLFAKLAEPKYQPLWRADETFLTRYALYNGVLRDLEKARQFATFTLPDACVNPIWTRFESSQGSNL
HKYEFLFDHLGPGRHAVRFQRLLVVESEGAKERDSVVVPVAPSGQLDKLVLREEEKSSVALHLHDTARPDGFMAEWAGAK
LQYERSTLARKARRDKQGMRSWRRQPSMLMSAAQMLEDAKQAGDVYLNISVRVKSPSEVRGQRRPPYAALFRIDDKQRRV
TVNYNKLSAYLEEHPDKQIPGAPGLLSGLRVMSVDLGLRTSASISVFRVAKKEEVEALGDGRPPHYYPIHGTDDLVAVHE
RSHLIQMPGETETKQLRKLREERQAVLRPLFAQLALLRLLVRCGAADERIRTRSWQRLTKQGREFTKRLTPSWREALELE
LTRLEAYCGRVPDDEWSRIVDRTVIALWRRMGKQVRDWRKQVKSGAKVKVKGYQLDVVGGNSLAQIDYLEQQYKFLRRWS
FFARASGLVVRADRESHFAVALRQHIENAKRDRLKKLADRILMEALGYVYEASGPREGQWTAQHPPCQLIILEELSAYRF
SDDRPPSENSKLMAWGHRGILEELVNQAQVHDVLVGTVYAAFSSRFDARTGAPGVRCRRVPARFVGATVDDSLPLWLTEF
LDKHRLDKNLLRPDDVIPTGEGEFLVSPCGEEAARVRQVHADINAAQNLQRRLWQNFDITELRLRCDVKMGGEGTVLVPR
VNNARAKQLFGKKVLVSQDGVTFFERSQTGGKPHSEKQTDLTDKELELIAEADEARAKSVVLFRDPSGHIGKGHWIRQRE
FWSLVKQRIESHTAERIRVRGVGSSLD
>AmaCas12b1
MKSIKVKLMLGHLPEIREGLWHLHEAVNLGVRYYTEWLALLRQGNLYRRGKDGAQECYMTAEQCRQELLVRLRDRQKRNG
HTGDPGTDEELLGVARRLYELLVPQSVGKKGQAQMLASGFLSPLADPKSEGGKGTSKSGRKPAWMGMKEAGDSRWVEAKA
RYEANKAKDPTKQVIASLEMYGLRPLFDVFTETYKTIRWMPLGKHQGVRAWDRDMFQQSLERLMSWESWNERVGAEFARL
VDRRDRFREKHFTGQEHLVALAQRLEQEMKEASPGFESKSSQAHRITKRALRGADGIIDDWLKLSEGEPVDRFDEILRKR
QAQNPRRFGSHDLFLKLAEPVFQPLWREDPSFLSRWASYNEVLNKLEDAKQFATFTLPSPCSNPVWARFENAEGTNIFKY
DFLFDHFGKGRHGVRFQRMIVMRDGVPTEVEGIVVPIAPSRQLDALAPNDAASPIDVFVGDPAAPGAFRGQFGGAKIQYR
RSALVRKGRREEKAYLCGFRLPSQRRTGTPADDAGEVFLNLSLRVESQSEQAGRRNPPYAAVFHISDQTRRVIVRYGEIE
RYLAEHPDTGIPGSRGLTSGLRVMSVDLGLRTSAAISVFRVAHRDELTPDAHGRQPFFFPIHGMDHLVALHERSHLIRLP
GETESKKVRSIREQRLDRLNRLRSQMASLRLLVRTGVLDEQKRDRNWERLQSSMERGGERMPSDWWDLFQAQVRYLAQHR
DASGEAWGRMVQAAVRTLWRQLAKQVRDWRKEVRRNADKVKIRGIARDVPGGHSLAQLDYLERQYRFLRSWSAFSVQAGQ
VVRAERDSRFAVALREHIDNGKKDRLKKLADRILMEALGYVYVTDGRRAGQWQAVYPPCQLVLLEELSEYRFSNDRPPSE
NSQLMVWSHRGVLEELIHQAQVHDVLVGTIPAAFSSRFDARTGAPGIRCRRVPSIPLKDAPSIPIWLSHYLKQTERDAAA
LRPGELIPTGDGEFLVTPAGRGASGVRVVHADINAAHNLQRRLWENFDLSDIRVRCDRREGKDGTVVLIPRLTNQRVKER
YSGVIFTSEDGVSFTVGDAKTRRRSSASQGEGDDLSDEEQELLAEADDARERSVVLFRDPSGFVNGGRWTAQRAFWGMVH
NRIETLLAERFSVSGAAEKVRG
>AsCas12a
MTQFEGFTNLYQVSKTLRFELIPQGKTLKHIQEQGFIEEDKARNDHYKELKPIIDRIYKTYADQCLQLVQLDWENLSAAI
DSYRKEKTEETRNALIEEQATYRNAIHDYFIGRTDNLTDAINKRHAEIYKGLFKAELFNGKVLKQLGTVTTTEHENALLR
SFDKFTTYFSGFYENRKNVFSAEDISTAIPHRIVQDNFPKFKENCHIFTRLITAVPSLREHFENVKKAIGIFVSTSIEEV
FSFPFYNQLLTQTQIDLYNQLLGGISREAGTEKIKGLNEVLNLAIQKNDETAHIIASLPHRFIPLFKQILSDRNTLSFIL
EEFKSDEEVIQSFCKYKTLLRNENVLETAEALFNELNSIDLTHIFISHKKLETISSALCDHWDTLRNALYERRISELTGK
ITKSAKEKVQRSLKHEDINLQEIISAAGKELSEAFKQKTSEILSHAHAALDQPLPTTLKKQEEKEILKSQLDSLLGLYHL
LDWFAVDESNEVDPEFSARLTGIKLEMEPSLSFYNKARNYATKKPYSVEKFKLNFQMPTLASGWDVNKEKNNGAILFVKN
GLYYLGIMPKQKGRYKALSFEPTEKTSEGFDKMYYDYFPDAAKMIPKCSTQLKAVTAHFQTHTTPILLSNNFIEPLEITK
EIYDLNNPEKEPKKFQTAYAKKTGDQKGYREALCKWIDFTRDFLSKYTKTTSIDLSSLRPSSQYKDLGEYYAELNPLLYH
ISFQRIAEKEIMDAVETGKLYLFQIYNKDFAKGHHGKPNLHTLYWTGLFSPENLAKTSIKLNGQAELFYRPKSRMKRMAH
RLGEKMLNKKLKDQKTPIPDTLYQELYDYVNHRLSHDLSDEARALLPNVITKEVSHEIIKDRRFTSDKFFFHVPITLNYQ
AANSPSKFNQRVNAYLKEHPETPIIGIDRGERNLIYITVIDSTGKILEQRSLNTIQQFDYQKKLDNREKERVAARQAWSV
VGTIKDLKQGYLSQVIHEIVDLMIHYQAVVVLENLNFGFKSKRTGIAEKAVYQQFEKMLIDKLNCLVLKDYPAEKVGGVL
NPYQLTDQFTSFAKMGTQSGFLFYVPAPYTSKIDPLTGFVDPFVWKTIKNHESRKHFLEGFDFLHYDVKTGDFILHFKMN
RNLSFQRGLPGFMPAWDIVFEKNETQFDAKGTPFIAGKRIVPVIENHRFTGRYRDLYPANELIALLEEKGIVFRDGSNIL
PKLLENDDSHAIDTMVALIRSVLQMRNSNAATGEDYINSPVRDLNGVCFDSRFQNPEWPMDADANGAYHIALKGQLLLNH
LKESKDLKLQNGISNQDWLAYIQELRN
>Ba2Cas12b1
MAIRSIKLKLKTHTGPEAQNLRKGIWRTHRLLNEGVAYYMKMLLLFRQESTGERPKEELQEELICHIREQQQRNQADKNT
QALPLDKALEALRQLYELLVPSSVGQSGDAQIISRKFLSPLVDPNSEGGKGTSKAGAKPTWQKKKEANDPTWEQDYEKWK
KRREEDPTASVITTLEEYGIRPIFPLYTNTVTDIAWLPLQSNQFVRTWDRDMLQQAIERLLSWESWNKRVQEEYAKLKEK
MAQLNEQLEGGQEWISLLEQYEENRERELRENMTAANDKYRITKRQMKGWNELYELWSTFPASASHEQYKEALKRVQQRL
RGRFGDAHFFQYLMEEKNRLIWKGNPQRIHYFVARNELTKRLEEAKQSATMTLPNARKHPLWVRFDARGGNLQDYYLTAE
ADKPRSRRFVTFSQLIWPSESGWMEKKDVEVELALSRQFYQQVKLLKNDKGKQKIEFKDKGSGSTFNGHLGGAKLQLERG
DLEKEEKNFEDGEIGSVYLNVVIDFEPLQEVKNGRVQAPYGQVLQLIRRPNEFPKVTTYKSEQLVEWIKASPQHSAGVES
LASGFRVMSIDLGLRAAAATSIFSVEESSDKNAADFSYWIEGTPLVAVHQRSYMLRLPGEQVEKQVMEKRDERFQLHQRV
KFQIRVLAQIMRMANKQYGDRWDELDSLKQAVEQKKSPLDQTDRTFWEGIVCDLTKVLPRNEADWEQAVVQIHRKAEEYV
GKAVQAWRKRFAADERKGIAGLSMWNIEELEGLRKLLISWSRRTRNPQEVNRFERGHTSHQRLLTHIQNVKEDRLKQLSH
AIVMTALGYVYDERKQEWCAEYPACQVILFENLSQYRSNLDRSTKENSTLMKWAHRSIPKYVHMQAEPYGIQIGDVRAEY
SSRFYAKTGTPGIRCKKVRGQDLQGRRFENLQKRLVNEQFLTEEQVKQLRPGDIVPDDSGELFMTLTDGSGSKEVVFLQA
DINAAHNLQKRFWQRYNELFKVSCRVIVRDEEEYLVPKTKSVQAKLGKGLFVKKSDTAWKDVYVWDSQAKLKGKTTFTEE
SESPEQLEDFQEIIEEAEEAKGTYRTLFRDPSGVFFPESVWYPQKDFWGEVKRKLYGKLRERFLTKAR
>BaCas12a
MESPTTQLKKFTNLYQLSKTLRFELKPVGKTKEHIETKGILKKDEERAVNYKLIKKIIDGFHKHFIELAMQQVKLSKLDE
LAELYNASAERKKEESYKKELEQVQAALRKEIVKGFNIGEAKEIFSKIDKKELFTELLDEWVKNLEEKKLVDDFKTFTTY
FTGFHENRKNMYTDKAQSTAIAYRLVHENLPKFLDNTKIFKQIETKFEASKIEEIETKLEPIIQGTSLSEIFTLDYYNHA
LTQAGIDFINNIIGGYTEDEGKKKIQGLNEYINLYNQKQEKKNRIPKLKILYKQILSDRDSISFLPDAFEDSQEVLNAIQ
NYYQTNLIDFKPKDKEETENVLEETKKLLTELFSNELSKIYIRNDKAITDISQALFNDWGVFKSALEYKFIQDLELGTKE
LSKKQENEKEKYLKQAYFSIAEIENALFAYQNETDVLNEIKENSHPIADYFTKHFKAKKKVDTSTSSVEKDFDLIANIDA
KYSCIKGILNTDYPKDKKLNQEKKTIDDLKVFLDSLMELLHFVKPLALPNDSILEKDENFYSHFESYYEQLELLIPLYNK
VRNYAAKKPYSTEKFKLNFENATLLKGWDKNKEIDNTSVILRKRGLYYLAIMPQDNKNVFKKSPNLKNNESCFEKMDYKQ
MALPMGFGAFVRKCFGTAFQLGWNCPKSCINEEDKIIIKEDEVKNNRAEIIDCYKDFLNIYEKDGFQYKEYGFNFKESKE
YESLREFFIDVEQKGYKIEFQNISENYIHQLVNEGKLYLFQIYNKDFSSYSKGKPNMHTMYWKALFDPENLKDVVYKLNG
QAEVFYRKKSIEDKNIITHKANEPIENKNPKAKKTQSTFEYDLIKDKRYTVDKFHFHVPITINFKATGNNYINQQVLDHL
KNNTDVNIIGLDRGERHLIYLTLINQKGEILLQESLNTIVNKKFDIETPYHTLLQNKEDERAKARENWGVIENIKELKEG
YLSQVVHKIAKLMVDYNAIVVMEDLNTGFKRGRFKVEKQVYQKLEKMLIDKLNYLVFKDKDPNEVGGLYNALQLTNKFES
FSKMGKQSGFLFYVPAWNTSKIDPTTGFVNLFYAKYESIPKAQDFFTKFKSIRYNSDENYFEFAFDYNDFTTRAEGTKSD
WTVCTYGDRIKTFRNPEKNNQWDNQEVNLIEQFEAFFGKHNITYGDGNCIKKQLIEQDKKEFFEELFHLFKLTLQMRNSI
TNSEIDYLISPVKNSKKEFYDSRKADSTLPKDADANGAYHIAKKGLMWLEKINSFKGSDWKKLDLDKTNKTWLNFVQETA
SEKHKKLQTV
>BdCas12a
MIYNVKLKKLTNSSDVFSLFSRKYSLSKTLKFELKPTAETKQHLQDFIVSDTKRAKEYKELKKIIDEFHKDYIELTLSHK
NILDKDKLTDFCKLWSDNNLLDEIKEKHNLKEKTKEEVIKKMEQQFRKDIVEQFKTLNPLLERFFKTADEEQLLGFLKKL
DNKLWTKFKEKKEKALLDEYLQEPIKQKNIEKSILFSSELIKYLLPVWLKNSQLTDKEDKQKIIKNFGRFTTYLTGFNEN
RKNMYSVEEQGTAIAHRIINENLMKFLGNLQAYEKIKSSHPELQQSFKNMKSDFKEEFDYFSLENIEDLFKPEFFNSCLS
QKEIDFYNTLLGGKTVEDGKKLQGINEYINLYRQKKKSEDIDIKIKYSNKNLPTMELLYKQILSDRESHSFILAEFENKK
ELLEALKSFWSVLFEEKTYQDYFHTKKKTSLWNNLHSLLTGRSYYDLEGAYFKSSELNKLSHNLFKDYRIITEALNENYD
KIKVTLESYKKVLKKEDKKEFEKNIKSLKGFQTEWKKILSFEKNKEELKFSDEILASYFEFPIDKKTKKKNQKDFYSLQE
IKDHIELYSKESDELKEDLDNLKKKLKDYKKDNIISSWFKYQFESKQNLDFFLQRNHEKENEDKREQNKNSLFSHIENHY
QKIQNLSLDEKEFKKEEVEDIKFFLDLILHVLHLMKPFYLEGKASNLLDKGINNEIEVLYKKLKPIEKLYNQTRNYIAKK
KSRYNKVKINFEDSTLLDGWDLNKEKDNLAVLLRKKDAVIGWKYYLGVMNKTTKDLFDYHIKLDDSEKVKQKKEELQDLI
LHRENDGNFYEKMNYKLLPDPSKMLPKVFFSKKNLDSFKPSEEIVRIRDNKTYAKNGGQDFSKADCHKFIDFYKESLKKH
KEWNDFFKFNFSPTSQYNDISDFFQEVKNQGYNLQFDKIKSSYIEEKVKTGELFLFEIYSKDFSTKSKNRKNSKDNLHTI
YFKGLFEKENLKDTVLKLNGKAEIFYRKATKKFNITHKKNTELENKNKNNPNKHSIFNYDLIKDKRFTEDKFFFHFPISL
NFNSKGMKSYLFNQEVLKCLKGNKEVNIIGIDRGERHLAYYTIINQKREVLSQGSFNKMESSYKDNSGKEVKIEKDYHEL
LESKEKERDKSRKEWNKIENIKELKSGYLSYLVHKISKLMIEHKAIVIFEDLNLGFKRGRFKFEKQVYQKLEKALIDKLN
YLVFKDKKSSELGGYLNAYQLTAPFESFQRMGKQTGYLFYVPAYYTSKVCPLTGFINLIYPKYKNVKESQQFFEKFDRIY
FDKNKNYFVFEYQDKKVNPSKKTESIETLWKVCTHGEERYKWDVKDRKMIEVNVTENLKKLFEEHKIEYRQIADLKSTIT
KQEKKDFFSKLIDGLKITLQLRHINPDSKDEKEKDFILSPVADESGRFFDSRKAKEGEPKNADANGAYHIALKGLRTLEN
ITSDKKDKLKLQAITNKDWFSFLKENSNKKIPKVG
>Br1Cas12b1
MAIRSIKLKLKTRTGPEAQNLRKGIWRTHRLLNEGVAYYMKMLLLFRQESTGGQTKKELQEELVRHIREQQQKNRADKNT
QALPLDKALEALRQLYELLVPSSIGQSGDAQIISRKFLSPLVDPNSEGGKGTSKAGAKPTWQKKKEANDPTWEQDYEKWK
KRREEDPTASVITTLEEYGIRPIFPLYTNTVADIAWLPLQSNQFVRTWDRDMLQQAIERLLSWESWNKRVQEEYSKLQEK
MTQLNEQLEGGQEWISLLEQYEEQREQELIENMTAANDKYRITKRQMKGWNELYEQWSTVLPNASHEQYREALKRVQQRL
RGRFGDAHFFQYLMKEEHHLIWKGNPQRIHYFVARNELKKRLEEAKQNATMTLPDARKHPLWVRFDARGGNLQDYYLTAE
ADNPRSRRFVTFSQLIWPNESGWMEKQDVEVELALSKQFYQQVTLQKNDKGKQEIEFKDKGSGSTFSGHLGGAKLQLERG
DLEKEEKDFEGGEIGSVYLNIVIDFEPLQEVKNGRLQSPYGQVLQLVRRPNEFPKVTTYKSEELVEWMKASQNHSSGVES
LESGFRVMSIDLGLRTAAATSIFSVEESNDANAAGFSYWIEGTPLVAVHKRSYMLKLPGEQVEKQVREKRDERQDQQRRV
RFQIRILSQVIRMAKKQNRERADELDHLSQALEKQKSLLDQTDRTFWNGIVCDLTDALREKEGGWEQAVVQIHRKAEEHV
GKVVQAWRKRFDADERKGIAGLSMWSIEELDSLRKLLISWSRRTRNPQEINRFEQGHTSHQRLLTHIQNVKEDRLKQLSH
AIVMTALGYVYDEKKLEWFAKYPACQVILFENLSQYRSNMDRSTKENSTLMKWAHRSIPKYVHMQAEPYGIQVGDVRAEY
SSRFHAKTGTPGIRCKMVSGHDLQGRRFENLQKRLISEQFLTEEQVKQLRPGDIVPDDSGEWFVTLTNGSGDKEVVLLQA
DINAAQNLQKRFWQRYNELFKVSCRVLIRGEEEYLIPKAKSVQAKLGKGLFVKKTDTVMKDVYVWDSQAKLKGKTTFTEE
SESPEQLEDFQEIIEEAEEAKGTYRTLFRDPSGVFFPEFVWNTQKDFWSEVKRRLYGKLRERFLMKTR
>ca2Cas12a2
MNSIKNEYQLSKTLRFGLTKKKKLLKDDCNEIIYESHTELKELVLISEKKIMESVYINQKAKLDLSVDQIDTCLSSIKNF
IDSWKGIYPRADQIAIDKDYYKILCKKITFDGFWIDEKTKTKKPQSRTILLSELSKKDASGKERKQHILDYWKNNIFSAI
EKYEVVSRELKQFQKALKIQRTDNKPNEVELRKLFLSLANIILDILKPLVNGQICFPKIEKLDISKTDNKNLIDFATNHK
FQSDLLNEIAELQHYFEENGSNVPFCRASLNPKTIIKSKLSTDNNIDKEIKQLGLDRILNEYLSAPYFDNSIIHLSAKEK
LNKIEDKKENYITRGLLFKYKPIQIMLHHEIAKTLSKEIGKSEENIIEFLGNIGQIKSPAKDYEVSKEDFNINNYPLKVA
FDFAWENVARNLYHTDTHAPIDECRKFLADNFDIKIEDNNLKLYANLLELNALLSTLKYGKPKDETSIKQNIKDLLNKIS
WNEIGKSGQKNKTNIENWLNNKDKIDNQNGIENAKKQIGLFRGSLKNKVPKYYKLTETYKDISMKMGKIFATMRDKITDE
AELNKVSHYAMIVEDDNKDKYILLQEFTDKKEECIYSKTQTHNSDFTTYSVNSITSSAIAKMIRKVKAEELRKNQYNKDT
FSIEETKEEKENRIIKEWKQFLKDKQWDYEFNLDTKNKNFEELKKEIDSKCYKLNISYIDKKTITDLVENKNCLLLPIIN
QDLSKEEKTQNNQFTKDWDAIFSQNTPWRLTPEFRISYRKPTPNYPISDKGDKRYSRFQMIGHFLCDYIPQSNTYISNRE
QIANYKDNEKQEQAVQCFHDKLLGKTEKEAKNEKLIALQAKFGSISRTNITQEKKKEKFYVFGIDRGQKELATLCVIDQD
KKIIDDFDIYTRSFNSKTKQWDHTFLEKRAIMDLSNLRVETTISIDGKTEKKKVLVDLSKVKVKDKQGHYSKPDKMQIKM
QQLAYIRKLQFQIQTNPDVVLAWYSDNNTQDLILENFVRKDDNDNKGLVSFYGAAVEELKDTLPIEEILNMLKQFKELKE
KEKAGENVKYEIDRLIQLEPVDNLKTGVVANMVGVIAFLLEKFNYQVYISLEDLSQPFDNKINGGITGVPIKTNKESGRM
ADVEKYAGLGLYNFFEMQLLKKLFRIQQKSTTILHLVPAFRAQKNYDHVTVGQDNIKGQFGIVFFVNANATSKTCPICGA
NNSEKPDKNKYPNAHKELAKDGKEVWIERDKSNGNDIIRCFVCGFDTTKTYEDNPAKFIKSGDDNAAYLISVSAIKAYEL
ATILAIEKYK
>ca6Cas12a2
MNHIYNNYQVSKTLRFGLTQKQKIRRPGYTGELYESHKVLKELVKISEEKVKNLIVPAKNEELLSSLDSVKWTLTEIREF
LDQWRYIYNKSNQIALDKSYYLILSKKLGFNDEKKSRVIKMIEIKDDIKEKIINYWAFNLNESNQKLLMVNEMVNTQLKA
LEINRTDHKINEIELRKALQSLFNTVLDILKPLVYREISFINLEKIEKDSKNSLLEKFATDFQRKIDLLEKIRSLKTHFS
ENGGNVSFCRATFNPKTAIKNPKSNDNSILKEIKKLGIKDILENNENVFYFEKKLAEITAKEKLEYIIKDSESFLIRSLL
FKYISIPAFLHHGIATELAPIISKEKNDLINFMISIGQIKSPAKDYADIPNKNDFNVNAYPIKVAFDYAWETVAKSQYHH
DINAPVSMCKTFLDENFENCTKTKYFTLYSDLLELHTLLSTLDYGNPSMEDSIIDKANKIIAKIDNKEHKTKDKDLDKDI
DKYKETIKNRLNHKNFNDKQRYSDAKKELSQFRGKLKNENDIYRKLTESYKKIAMNTGKIFAEMRDKISNASEQNKISHH
ALIIEDHNKDRYLFLQEFTTDKEKQIESICNDQAGQYIVYWVNSITSKSISKMLSKKRIEKLKQKKIINNSIKTSILSDA
EKEARDIKEWVSFIKEKGWDIDFNLDLQNKNLEEIKKEVDAKAYKLKETLISQKTLSNLVKEGNCLLFPIINKDLVKKVK
TEKNQFTKDWNSIFKKDNLWRLTPEFRVSYRQATPGYPTSDIGTKRYSRFQMTAHFLCDFLPQGTKYISNREQIENYKSS
EKQKEAVEIFHQQIENDNNNVISTQSLNHLARHFGSKNIKKKHNTIEKKFYVFGIDRGQKELATLCIIDQDKKIEGPFKI
YTRSFNTKTKQWEHQFYEERYILDISNLRVETSISIDGKPDQQKILVDLSYYKEGEKFIKLPKMQVKLQQLAYIRKLQYQ
MQRNPETVLDWSYKNTDDKSILENFVDKPNGEKGLVSFYGAAVIELKDTLPLSEIKDMLERFKELKGKEKNGEDVSQQLN
ELTQLKSVDHSKYGVVANMVGVIAHLLERYDYKAYISLEDLTKPYSAIDGITGQKTDAKSISGKQQDVEKYAGLGLYNFF
EIQLLKKLFRIQKDSQNTLHLVPAFRATKNYENLIAGEDKVKNRFGIVYFVDPKSTSIMCPSCGKTNNSSNKEKRVVRDK
KNGNDIIYCEFCGFDTRNDYKENPLKFIKSGDDNAAYIISTHTAKKAYELAKSIL
>ca7Cas12a2
MSLAAFTNQYQLSKTLRFGFTQKEKVRKENFDGSIYQSHAALRELTIESERLIKGKLKSNTDTALPLEKIRACIEEIKRY
TDTWSKIFTRDDQLALSKEYYRVMARKARFDAFWKNYRDVKQPQSQIVRLSSLKSKYNGKERKAYLVDYWAGNLQTVKQR
LVDFEPAIRQFESALKDNRTDRKLNEVDFRKMFLSICKLVNETLVPLCNSSLCVPDLEKLLDNEASQELRDFVMMDIFQL
QEQIEALKIYFGENGGYVPYGRTTLNKYTALQKPHAFDEEIEAILVKLKLSDVINNLIKQDDVSDYFENVKDKIGQLSNS
SMSVIECVQLFKYKPIPVSVRYSLVEYFHRKLGIDKDELGTLLDTIGKPKSPAKDYADLQDKGDFNLYKYPLKVAFDFTW
ESLAKAQYHEGLNFPEVQCQKFLENIFFVNTSCEAFKTYALLLHLRGLLAKLDHEEPNDREAIIDKAISLMNEDAFPKVP
LRGTKGDSANQAILSWLQLSKEEQVYKKEKKDQSYNQYEKAKNKIGLLRGEQKNKIGKYREVTEQFKDLASNFGKLFGAL
REKFQAKNELNKITHYGTIIEDNNQDRYVLLYPLSEGIIDLDKLFVHEESGTLTSYYVKSLTSKTLNKLIKNKGGFKDFH
MDGQQPDWERVKKRWSVYKDDKAFLKYVKRCLNESEMAKAQNWGEFGWDFSSCDSFEEIEREVDKKGYSFKNDRKLSEDT
VKRLVKEEKCLLLPIINQDIIVEETKLRNQFSKDWVNIFDADCTEYRLHPEFGMSYRMPTPNYPKPEQKRYSRFQMIGYF
QCEIVPIKTEYLSKKEQIEIFNDADAQKEAVEKFNEIVNGSVKPNDYVVIGIDRGLKQLATLCVLNKDGAIQGGFEIYTR
SFNADKKQWEHRFMDNRDILDLSNLRVETTVDGKKVLVDLSSIKVKDQRGNYTQDNQQKVKLKQLAYIRKLQYQMQVNPE
KVKAFAAQHRTPQDIKDHMKELITPYKEGSHFADLPLDRIKYMLEAFCAFHTENDQTSLRELIELDAADNLKSGIVGNIV
GVIAFLLKRFSYNAYISIENLTRAFYNQRDGLSEKEIPRDHDFMDQENLVLAGLGTYHYLEVQLLRKLFRIQCDAGIINL
VPAFRSNDNYETTRKLSKKQGVEYVCKPFGIVHFVDPMYTSKKCPACGGTTVQRGSFKDDITCQNPLCGYGTSLDISEKI
QKLISANKAGQNIHLISNGDENGAYHIALKTLKNLFGNIQNANNERRYVKSFRSK
>ca11Cas12a
MKNLSDFTNLYSLSKTLRFELIPQGKTLEHIEKNGLLEQDRQRADSYQKVKKIIDEYHKAFIKRSLKGCKLSNELLTDYY
FYYNLKLKRDETQKKKIEELQSKLRKEVASKFLNLKELESADLYNASKKDNRAEGKLNSWLKEKPHIAAKLIIDLKLNQH
YSFEDDLKRFESFATYFTGFHENRKNMYSADDKATAIAYRLIHENLPKFIDNINVFEKVKNSDVAQNFEKLYKDLEEYLN
VLKIEDIFQLDSFSDFLTQEQIDVYNAVIGGKAEEQGKPKIQGLNEHINLYNQKQTDKDKKLPKLKPLFKQILSDRDTIS
WLPEEFKKGNDNEVLESIEKCYQELCNEIFAPDKKQPLIGLLLNLNDYDLNKIYLRNDTSLTDISQQLFGSWAVIQKAVE
TKYERENPRKKNEEEEKFAKRKDKFFKNYDNFSIGYLSDCLKCLDNYDDLPTKNIADYFTNLGKKEDSENLFSQIEKNYA
EVKNLLNTPYSGDKDLAQDKNAVEKIKIFLDSIKSVQWFVKPLLGKNESDKDEKFYGEFTPFWKELDKITPLYNKVRNYM
TQKPYSEEKIKLNFENSTLCNGWDKNKEQDNTAILLRKDGNYYLAIMNYRAKTNFDKTEIAKESESFYEKADYKLLPGPN
KMLPKVFLSTKGKAEFNPSSEILENYENGCHKKGDTFDKDKMHKLIDFFKISIAKHKDWKNFGFNFSDTPSYESIDKFYK
EVLEQGYKISFRNISEKHINELVEAGKLYLFQIYNKDFSPYSKGTPNMHTLYWRELFSEENLKNVVYKLNGEAEVFFRKS
SIKSENKIEHKANEVIKNKNEQNKKLESTFKYDLIKDKRYTVDKFQFHCPITMNFKAEGTENINPKVNQFLKENANNIHI
IGIDRGERHLLYLSLIDAKGKIIKQFSLNEIVNKHNENTYTTNYHSLLDEREKERQKERESWKVIESIKELKEGYISQVI
HKIAELMVEYNAIVVLEDLNMGFMRGRQKVEKSVYQKFEKMLIDKLNYLVDKKKQASEQGGTLQALQLTNKFESFQKLGK
QSGFLFYVPAWNTSKMCPVTGFVNLFDTRYENVEKAKAFFSKFDSITFHSAKNYFEFEVKDYSKFSGKAEGTRLNWTICT
NGTRIETFRNPEQNNNWDNREVNITDEFVKLFGTKNADFKNLIQQQSEKAFFERLLYLFKLTVQMRNSITNSDIDYMISP
VADKNGRFYDSGNCDEALPDNADANGAYNIARKGLWIIEQLKQTEDLKKPRLAVSNKEWLQFVQKLNK
>ca11Cas12a2
MEKNEIAISEYQTQKTIRFGLTATNQNLYSEEIMKLLDISEKRVEKQAEQAKKVNNDADKNNQLRCCLDQIKEYLKTWSN
IYPQIDFLAITKDFYKVISKKARFDFDKGNGSEIKLSYLQSTYYNKKRYLYIIESWKENLRKTENLYRKSDDLLKVFEEA
KNQNRDDKKLNKVELRKTFLSLFNLVNESLKPLIEGNLFIVNDDKIDEQNPKHDCVSVFISKTEERRKLYDYICDLQDYF
KDNGGYVPLGRVTLNKWTALQKSNNRDAEINRIIKELKINSVSIQNIEYEYNNFANNFKEKKDENGKIVKNNAGNIIWDL
KADAKSVIEICQFFKYKQVPINARLNLAKRLEKSIDFLSEFGVSKSPALDYKNDKNNFNLTNYPLKIAFDYAWENCAKAK
HEEIPFPKEQCEKYLKDVFDIDIECKEKCQNKECKGCEKCRGYYLNKYADLIRFKILLGRLKAEFHKTDEEKNKSNIQEL
RNIFRDLDYRGDKRLNKNEIQKAVNAWFDNKEQSIGRKKEDEIHLMENEKNKFSLSMQIIGQERGGLKSRISKYKALTEM
FKVCASKFGKQFADLRDYFNEAYEVDKIKYRAWIIEDEKQNRFILFVNKEKEVDLTSEEGDLYFYEVKSLTSKSLVKFIK
NRGAYPDFHKINNRQIDLNSGEKDSRGNFIDDVKIHWSTYKNNQKFLDKLKDCLQNSTMATVQKWSEFEFEFDFSNCDTY
EKLEKEIDRKGHKLERKTISLTTITNLVENTACLLLPIVNQDLNKGNKQAKNQNQFTKDWFDIFENKKRLHPEFNIFYRF
KTKDYPNTKFKNGTEKTKRYSRFQMLAHFGCEVIPQGDYLSKKEQIAIFNDDKKQTEEVKKYNKNISSDVDYVIGIDRGI
KQLATLCVLDKNGVIQGGFQLFTRTFNSETKQWEHQELEKRNILDLSNLRVETTITGEKVLVDLASIQTKNGENRQKIKL
KELAYIRDLQYTMQTRASDLLDFASKINSADDITENNIKNFISPYKEGEKYADLPQKEMFDLLTEWKNAEEEGKRKIAEL
DPADNLKSGIVANMVGVVALLCAKYKYRVRIALEDLTRAYGIQKDALSGATIFQNDEDFKEQENRRLAGVGTMQFFEVQL
LKKIFKVQIDKDLHLIPAFRSIANYEKIVRRDKQNSGDEFVNYPFGIVCFVVPKYTSKRCPKCEKTNVNRKENIVICKEC
GFQTKEGNPYEKNNIHFITDGDQNGAYHIAKKAL
>ca14Cas12a2
MLESFKDLYEVRKTERIGLTQPNKKGEKISHLELNELVKTSLERIKSDIDKDDNSIIKNEKNLIKNSRQFVNELNVQFGT
WKNIYKRYDLISVNKDYYRILARKAKFDAFWKEGRTKYPKANQITLSSLQKGGRKEKIIEYWKEIIERSYYLISIFTQKL
DQYENAVSNPEKLSHTKPDFTDFRKIFLQLLKVSEDYLKPLFDKSINFKTGKKLESEEDIKEINLFISEENNKNIYSLLK
LGNDIREYFEENGAQVPYKKVSLNYYTAVQKPNNFEGEIKKAIEDLWIVEFLNKSDSQIINYLHQGSKQKKNYYLLQNIL
ILLSYYSYLKVKPILFSVKYNLAKFMEKNYKSEINLSYEDILNKFNLLGRAIDIANDFKNSNNQNNFSLDEYPIKLAFDY
AWENTARSLKRTIPFPKEVCKQFLKDNFDVDIDNADFKLYANLLFIADNLATIEYNNPNNEVELINEIKQAFECISFPFD
KEVYKGHKEAILELLDKEKSQRDYSTILKAKQELGLLRGGLKNKIKKYRDLTQRLIDKKNSHFGIASFVGKTLATIRDGL
KEENELNKISDYGVIIEDSNQDKYLLTLELNGKDIRDRIRNSLGNGEYKTYEVNSFTSKALNKFIKNPLSEDAKKFHGKY
KDEYSFGYENKDGDFTYKITKVSKYDEQGKWTGYQESFLSHIKKCLIDSEISREQNWEAFGWNFAGCNTYEEIEKEVDSK
GYQLTENLISMGNLKSLVKDEGCLLFPIINQDISSQKQENKNIFTLDLEKVFEGKECRIHPEFSIFYRRPIEEHKKENKS
GIINRFGRLQLLANLGIEFVPRNPSFKTKKEQNRIAIDQKKQNQLVQEFNQKKVNTYFEGLDNYYIFGIDRGIKQLATLC
VTDKDGVIQDFDIYTKHFNSESKKWEYKFHRKDGILDLTNLKIESDRSGNKYIVDISLFQAKDEDGNPTGTNKQNIQLKQ
LAYIRKLQYQMSANEEGVLNFLGKYKNKEEREQNMEELITPYKEGKNFADLPMDIFQEMFENYYRLKTDQNLSESEKKNL
MKITTELDASESLKKGVVANMIGVIYYLMKKYEYKVKISLENLSNAWLFSKDGLSGDVVLNTKNDETMDLKKQDNLALAG
VGTYHFFEMQLLNKLFKISTEEGVLHLVPSFGSVKNYIEIMKIKGKYVYKQFGIVYFVDPRNTSKKCPVCGKGGKKYISR
VDNVVTCKNCGFDTSSDNSILINNYKKQGKNIHFIKNGDDNAAYNIGEKIR
>ca17Cas12a2
MEEFKNLYQLSKTLRFGLTLKDKKRKDGYTKEIYGSHNQLKDLVRFTEKRIEEEITTVGINYTAELLAEKIRKCLNNMQS
FISQWNKIYYRKDQVAVDKDFYKKLSKKNWIQRFLVCKEKNKREIKRIKQPQARIIKLSALDEEDEYNRTRKDYIIDFWR
ENIQNAFNKYKEVERVLEEFDFAIKANRADKSPDEVEMRKMFLSLANIVCEVLVPLCNGSICFPDIEKMSDKDENKYLRE
FAVDYKTKIDLFDSISELRKYFEENGGNVPFCRATLNPKTKIKNPSSTDNSIEAEIEKIGMEKYLQTTDEIITAINKIKQ
MQDSKLPLIKRALLFKYKTIPAVVQFDLAKSIGKKLNKEEQELRTIIRTIGQTASPAKDYADLQHKKEFNINQYPLKPAF
DYAWESLAKAEYHNDIEFPNQICKQFLKDIFNVDTETDSYFKLYAQFLYLRELLATLEHSQPTNPEKIVKIIEELLEKIN
AWKEIDDKNSEKYKTAISNWLKTFNKEDNNFKNAKQKIGLFRGGLKKKAGDKSRWEYLRKPDEKEAPKLTAYNALTQIYK
DIATNLGRNLADMRDKITNESELNKISHYAAIIEDKNGDKYVLLKKSDKDEEFALPCEKDAEYKTYIVNSITSSAIAKMI
RKKRAADLAKNIRLKSEELNDEQKEAKNLKDWIELIKKQQYDFEFNLNLNNKNFEQIKKEIDAKCYQLQKGNISKQTLEK
LINEQKEWLLLPIINQDLAKRDKSTTNQFSKDWQKIFSDKRCGYRLTPEFRISYRKPTPNYPQSQIGDKRYSRFQMIAHF
LCDYIPQGNLEYKSTRQQIEIFKDYEKQEESVRNFTYKIYANNDYLIFGIDRGLKQLATLCVLNKEGKIYGGFDIYTRSF
NKDKKQWEHSLSEKRNILDLSDLRVEKTITGEKVLVDLNSIKVKGNQDNQQKIKLKELAYIRKLQFKMQTEHGTVINFIN
KYRTPEEIQKNIHELITPYKEGEHYADLPTEKICNMLQKFKEFSDKNDGKSKRELIELDSAGELKNGIVANMVGVVAYLL
EKYKYNVYISLEDLTRAYRRQTDGLDGRELFSSNDDKSVDFKDQENTALAGLGTYHFFEIQLLRKLFRIQQEDGNILHLV
PAFRSVDDYEKIIRRDKKIDGNEYVDYPFGIVRFVDPKNTSKRCPLCSSININRHKNIIKCQQKACGFKTPWDKTNDKNI
QYIQNGDENGAYHIAKKTLDNLNNKK
>ca33Cas12a
MSLTQFTNLYPIQKTLRFELKPIGKTEEHIQKNRLLENDQKRADDYDVVKDLIDSYHKWFIEETLQAVSLDWSALQAAIA
NQRTEKSPASKKALEAEQALMRKKINKAFESHAKFKLLFSEKLFKEILPAHLNVLEATDEQRKAVDTFKRFSGYFLGFHE
NRKNIYSADDISTGIPHRIVQDNFPKFLNNAQIYAALPPEIKDAINAALQEDLNGRALDEVFSIGFYNTVLTQKGIDFYN
LIIGGRSPEPGQRKIQGINEIIHQYRQQYPDVKIPKMVELFKQILSDRESQSFIPKMYENDKEVQESIVHFHDTELRGFT
QEDREVDVLTGLANLAKGIAGFDLAHIHVTAASLPELSKTLLEEWNTLQRYIETYANERFKTKKDKEKFLKSETFSLDEL
NAVLEHNEQAKRIQSFWNEAADERLKAIDETHAKAEAILRKEYTAENKMRENPDDIALIKEFLDAVMDFMRWLKPFCIQS
EVSKDDSFYGEFEPLYKQLALVVPLFNRVRNYATQKLAETAKIKLNFENPTLANGWDKNKEKDNTSILLMKDGKYFLGVF
NVDNKPGVDGACVQTVTEACYTKMIYKLLPGPNKMLPKVFFSKTGREAFDPPQYILDGYEAEKHKKGDAFDKTFCHNLID
YFKDAIQQHPDWKQFDFQFSDTASYEDISGFYREVQQQGYKLTFTNIPERIISQWVDEGKLYLFQLSSKDFAAGTTGKQN
LHTLYWTQLFSPENLKDVVVKLNGEAELFYRRKSIEKPFIHRVNEKMVNRRDRDGNLIPEKIFGELFRYFNAPDQVTLGE
EATKWKDKTVVKPVKHEITKDRRYTEDKFLFHVPLTLNFKADGARLNEQVRGFLINNPEVNIIGIDRGERNLIYVTIINQ
KGEIIFTRSFNEVNGFDYHEKLAQREHERDAARKSWQSIGKIAELKEGYLSQVVHEITKLMIQHNAIIVLEDLNFGFKRG
RFKVERQVYQKFEHALIDKLNYLVFKERKASEPGGVLKGYQFTEPLAAFKDVGKQTGMLFYVPAAYTSKIDPVTGFANLL
NLNYDNERKSKELFSTTFDFIRYNSKEDFFEFGVNYEKAKTHVTDYTSEWTVCTTNEPRYAYNPQTKKTETVMVTERLKA
VFAENKIAFEDGRDLKKDIVERGSVGLYKTLIWLLKLVMQMRNSNAETGEDYILSPVRNKAGVFYDSRKADDTLPKDADA
NGAYHIALKGLYLLQEVFNKTQSEKDKVDLKITHPDWLAFAQKRHEVK
>ca33Cas12a2
MDADKTTKAINEYQTQKTIRFGLTATNQNLYSEEIMKLLNISEERIIKEKVKVNNDTDKTNQLRGCLVQIKKYLKTWENI
YAQIDFLAITKDYYKVISKKARFDFDKGNGSEIKLSSLQSTHNKKKRYQYIIDFWKENLRKTENLYRKSDDLLKIFEEAK
NQNRDDKKLNKVELRKTFLNLFTLVNESLKPLIEGNLFIVNDDKIDEKNSKHNYVFYFISKTEERRLLYDNICTLQDYFK
NNGGYVPFGRVTLNKWTALQKFNNRDIEINRIIKELKINNISTQKTDYKYNDFTENFKEKKDENGKVVKNSAGNIIWDLK
ANAKSVIEICQFFKYKKVPINARLNLAKRLIKDNKLKKEQENTFLSEFGVLKTPAFDYARDKENFNLTNYPLKVAFDYAW
ENCAKDKYEKIPFPKEQCERYLQTAFEIDATKDENKKLIDTHLNKYADLLQFKILLERFKAEFHKTNEETNKNNIQKLRN
VFSGLDYHGDNRLNKNQIQKAIEAWFDNKEQNIGKKKENEKLLTENEKNNFSLSMQIIGQERGGLKNGIPKYKELTEMFK
VCASKFGKQFADLRDYFNEAYEVDKIKYRAWIIEDDKKNRFVLFVNKEKAFDLTSEEGDLWFYEVKSLTSKSLVKFIKNR
GAYPDFHDVKNSFHYSSIKKDWQNYKNDPEFLDKLKECLKNSKIAKDQKWAKFCWDFKQCDTYEKLEKEVDRKGYKLEGC
KSEPKTISLTQLTDWVENKDCFLLPIVNQDINKGDKRTKNQNQFTKDWFDIFENKKRLHPEFNIFYRFPTKDYPNTKFKN
GTEKTKRYSRFQMLAYFGCEVIPSGNHLSKKEQIAIFNNDKKQKEEVEKYNKSISSDCDYVIGIDRGIKQLATLCVLDKN
GVIQGDFQIFTRTFNKQTKQWEHKELEQRNILDLSNLRVETTITGKKVLVDLSKIKDDEGNYTNLKQTIKLKQLAYIREL
QYAMQTRPDDLLDFVKSINSANDITAENIKHFISPYKEGKNYDDLPKVEMFNLLKEWGNADENGKRKIAELDPADNLKSG
IVANMVGVVAFLCENYNYKVRIALEDLTRAYGIQKDALNGTAIYQNDEDFKEQENRRLAGVGTMQFFEVQLLRKLFKIQV
DKNLHLIPAFRSVDNYEKIVRRDKQNSGDEFVNYPFGIVCFVDPKYTSQQCPYCNNTHKHKKNDTETGKKAFYRNKGENK
NSLLCEKCGVSTIEGEETLSSKNDNKKQFNIHYITDGDQNGAYHIANKVVINFQKDS
>ca34Cas12a2
MEKIKNKYQVSKTLRFGLTQKEKRRKKGFVGEVYESHTELKDLTDFSVKKIRAEIKQGGNSGIPIEKIRQCLIVIRRYMN
FWENIYYRCDQLSLDKDFYKKLSKKIGFEGFWHEENRKTDHRIKKPQARTIQLSELNKKDDHYKERKDYIVEFWESNINK
AAERFKETESVFEKFEIAINANRDDNRPNEVEMRKMFLSLANIIYETLVPLCNGSISFPNIEKMQNNEENNNLRKFAADD
EFRAGLLTQIEELKAYFEENGGNVHYCRATLNPKTVIKNPNSTDSSIADEVEKTGIERYLQNKQEIKNKIEKIKDKNLPL
IERALLFKYKTVPAGVQFDLAKFLSVKLGKTEQELRTIIRCIGQIQSPAEDYAKSEDKKGFHLEQYPLKSAFDFAWESLA
KAIYHKNVDFPQQQCKVFLEKNFDIKIDSNANFKLYAQLLYLRENLATLEHSKPTDPDTFEKNIRKLLDEINWSTIDKEK
GSVYKNAISDWLKNKKAKDEKFGKVKQSIGLSRGRLKNKIKKFDDLTKDYKDIATQLGNAFAAMRDKITNAAELNKISHY
ATIIEDKNGDRYILLQKVTENEKPVGENWNKNGELKTYLVNSVTSAAISKMIRKIRTDELRKNEKMQSSITKLNEKQKEE
KNINDWKNFIEEKRWDLEFKLDLKSKNFEQIKKEIDTKCYLFNTGYASQADIKQLVKEKDALLLPIINQDLASKDKIVRN
QFSKDWQMIFSDNSQGYRLTPEFRISYRQPTSNYPQPEEKRYSRFQMIAHFLIDYIPQNNQYISTREQVELFKDETKQRE
AIEEFHKQLTPKTEAEQKAESLSALAAKFNNPNNKKQKNNASENKPDEKFYVFGIDRGQNELATLCVINQDKKIIGDFEI
YIRKFNSEKKQWEHLKLENRHILDLSNLRVETTIVIDGKPEKKRVLVDLSEIKVKDKNGEYKNPDKMQTKMRHLAYIRKV
QFQIQNNPEGVLDFLKKFKTKNETIYNLVDKENGEKGLISFYGAGNTNEDLPKDDIWKILQKFQELKNKTGDDNVKKEIK
ELIELEPVDNLKNGVVANMVGVIAYLLEKFDYQVYIALEDLTKPFNEDIKDGTTGVKGNYKGEGKRADVEKYAGLGLYNF
FEMQLLKKLFRIQQENDNVLHLVPAFRAVKNYENLIAGKGKIKNQFGIVYFVDANSTSKTCPVCSSIPDKNNSNNKNAKG
KKIINKKGNESVIWVERDKSNGNDIIRCYACGFDTTKNYSENPLKYIKSGDDNAAFIISTLGIKAYELAKTLVANK
>ca35Cas12a2
MKSFENSCQISKTLRFGATLKEDKKKCKSHEELQEFVDISYKTMKSSATIAESLNEIELVKKCERCYSEIIKFHEAWGQI
YCRTDQIAVYKDFYRQLARKARFDVGDQNSQLITLSSLSSKHNVYQGLKRSQHITNYWKDNIARQKSFLKDFSQQLHQYK
RALENSDKAHTKPNLINFNKTFSILANLVNEIVIPLSNGAISFPNISKLEDGEESRHLIEFALNDYSDLVGSIGELKDAI
ATNGGYTPFAKVTLNHYTAEQKPHVFKNDIDAKIRELKLIELVEKLKNKTSKQIEEYFSKFDKFKIYDDRNQSVIIRTQC
FKYKPIPFLVKHELAKYIAEDEDAVLKVLDAIGATRSPAHDYAHNEDVFDLKHYPIKVAFDYAWEQLANGVYTTVSFPEE
KCREYLNAIYGCEVTKEPVFKFYADLLYIRKNLAVLEHKNNLPSNPEEFICKIENTFEKIVLPYKIKEFETYKKAILTWI
NDGRGHEKYTDSKRELGLIRGGLKGRIGAQKMFRKNKKGELIPYYENPYTKLTNEFKNISSSYGKTFAELRDKFKEKSEI
TKITHFGIIIEDNNKDRYLLANGLQHDNTDQSNTQVEAILGKLNTSLEFTTYQVKSLTSKILIKLIKNHTTSPNAKSPYA
DFHTSKIHVDWTKIKKEWDTYKSNHSLLQYVKDCLTNSTMAKNQNWAEFGWDLESCNSYEAIEHEIDQKSYILQKHTISK
ASIKSLVENGCLLLPIVNQDITSQGRKDKNQFSKDWKQIFEDSKEYRLHPEFAVSYRTPIKDYPKDKRYGRLQFICAFNC
EIIPQNGEFINLKKQIENFNDEDIQKNNVAEFNNKVNEALLGKEYVVIGIDRGLKQLATLCVLNKRGKILGDFEIYKKEF
VRTENRSKNYWKHTLAETRHILDLSNLRVETTVEDNKVLVDQSLTLVKKNRDTPDEKATEENRQKIKLKQLSYIRKLQYA
MQTNEQAVLDLLKDNSDDEEFKKRVEGVISPFGEGQEYADLPIDTMRAMIQDLQGVIAKGNKQTEKNKIIELDAADSLKQ
GVVANMIGVVNFILAKFNYEAYVSLEDLSRAYNVAKSGYDGRYLPSTSQDPDMDFKEQQNQMLAGLGTYQFFEIQLLKKL
QKIQSNNTVLRFVPAFRSADNYRNIIKLNPKYDNTEYVHKPFGIVHFIDPKDTSSKCPVCGKTGKKNVDRNEKKNNILLC
KACGFRTVWELKQPENIKSEGYCFSEDEIQKTIKNNQKQMEIKKLSDKNIHYIHNGDDNGAYHIALKSVENLKHKE
>ca36Cas12a2
MKSIVNNYQISKTLRFGLTQKTKIQKEGYNGEIYVSHRELCDLVKISEERIKKSVSASDKSNLELSIDIIDTCLKQIGVF
LSDWQQVYYRKDQVALDKDYYKILCKKIEFDGFWKDDRGQRMPNSRIINISELDKRDSLGVERLHYILNYWKDNLVSASQ
KYSAVEEKIKRFKSAIKINRTDNKPDEVELRKMFLSLANIVCDTLQPLCYGQISFPKINKLDDSRTDNKKLIKFATEYKS
KNDLLTSIAEQKKYFEENGGNVPFCRATLNPKTAIKDPNSTDNSIKGEIAQLGLDSILKSFKSYLFFENSLENMSAKEKI
DLMKSDGASIIKKGLMFKYKPIPVIVHREVAQELSEDLNKTEESLSDFLRGIGQAKSPAKDYEELTDKNEFNIEAYPIKV
AFDFAWESLAKAKYHSEIDLPVDSCKKFLKTFDVTPDDANFLLYAQLQELNALISTLEYGYPSDEQSIVKKIKALSNEIQ
WEKVSDRNGQEYKRSISDWADGKRDSDGFKIAKQNIGLFRGGLRNKIDKYYSLTQIYKKTVMDEGKIFAIMRDKIIGAAE
QNKVTYYAAIIEDNTGDKYVLLQELPLNGQDRIYDKMTRDGDGYVCCFVNSITSRTIAKQLRKKRMAELKKNKAWGAYND
NVSNTQQPVLSDEEKEERNIREWKSFISEKRWDCEFNLNFKGKNFEEIKKEIDAKGYELENRRLSREALDELVKNNKCLL
LPIVNQDIIKENKTESNQFTKDWNSIFDDNSPWRLTPEFRVSYRKPTPDYPVSSKGDKRYSRFQMIAHFLCDYIPNSDSY
VSVREQIENYKDDKKQETAVKDFHNRLLGKTEEQKIIDRLGAFQGWGNVIIKKTKPEKQEGSKEKFFVFGIDRGQNELAT
LCVIDQDKKIQGGFKIYTRSFNSEKKQWEHKFLEERNILDLSNLRVETTIVIDGQEKKEKVLVDLSEVKVKDHFGNYVKP
NKMQVKLQRLAYIRKLQFQMQTNPERVLEWYSHNQTNDLIINNFVDKQNGEKGLVPFFGAAVAELKDTLPIDRISEMLKQ
FVELKNLEKQGEEVKSKIDQLIELEPADNLKSGVVANMVGVIAFLLEKYSYQVYISLEDLSKPFENQIVLGISGVPIGIN
KGMAGRSVNVEKFAGLGLYNFFEIQLLKKLFRIQRDSCHILHLVPAFRAMKNYDNVAVGKGKIKNQFGIVFFVDAAATSK
TCPCCGANNSKKFEPDFRKFPNAKKFETPDKKSVWLERDKSDGKDIIRCHVCGFDTSKEYDDNPRKYIKSGDDNAAYLIS
AEGVKAYELATTLVDNK
>ca37Cas12a2
MINLENFKNLYEVRKTVRFGLNQPNKKGDFKTHLEFKDFTEKSFQNVENELASNGKYNIGDEEQLIKKISAFVEQLKIQL
GYWKVFYQRYDLIAINKDYYKILARKAKFDAIWEISKSNKYIKVKQPQASQISLSSLKIGNRSDSIIQYWGEIIEKTDYL
LNIFKPKLEQYERAIKDANNAHIKPDSINFRKTFLQLLKLTKEFLQPLSDRSIIFEFSKKKVSKEIEKISEFAGEKNNTK
IYNVLKNGEELRQYFEANGSQVSYGRVSLNYYTAVQKPNNFDQEIKKSIDDLGIINFLKKSDSQIIDYLHQGSKQKIKLL
LTSKHPYPIELLQLFKVKPIPFSVKYNLAKFVEKNYKSETNLSYEDILNKFNLLGRAIDIANDFKNSNHKGNFSLDEYPV
KLAFDYAWENTARSLKRDISFPKKVCERFLKDNFDIDVDNADFKLYANLLFIADNLATIEYNNPNNEAELINEIKQAFEC
MSFSFEKKVYEGHKKAILELLDKEKSQRDYSTISKAKQELGLLRGGLKNKIKKYRDLTQRLIDKKNSHFGIASFIGKTLA
TIRDGLKEENELNKISHYGVIIEDNNQDKYILISKLEGKDRRDKIVQKLGKGDIKVYQVNSFTSKALNKFIKNPLSEDAK
KFHGKYKDEYGFGYENKNGDFTYKVKNVSEYDEQGKWIGYQEEFLNHIKKCLIDSEISREQNWTAFGWSFDGCNNYEEIE
KEIDSKGYQLTENSISKGNLESLVKDEDCSLFPIINQDISSQKQENKNIFTLDFEKVFERKECRIHPEFSIFYRKPIEEH
KKENKSGIINRFGRLQLLANLGIEFVPRNLSFKTKKEQNRIAIDQKKQNQLVQEFNQEKVNTYFEGLDNYYIFGIDRGIK
QLATLCVTDKGGVIQDFTIFTKHFNQASKIWEYRENRKEGILDLTNLKIESDKNGNTYIVDISLFDAKDDNGRSTGTNKQ
NIQLKQLAYIRKLQYQMSANEKGVLDFIAKYISKDEREQNIKELITPYKEGKKFADLPMDIFQEMFENYYRLKTDQNLSE
FEKKNLMKITTELDASENLKKGVVANMIGVIYYLMKYYDYKVKITLENLNQSFGGQVDGINNHYVDIKNNFMYQENQALA
GVGTYHFFEMQLLKKIFKISTEEGILHLVPSFGSVKNYFKDIEKYSLIVNIGRNEKYNQFGVVHFVKPDNTSKKCPVCLN
TQTTGKKEGMPIINRNYKKSNIFYCERCGFQSIHSHCQEENIKDSNDFHYSVEEVERIEMKNKEAIEKYKKQGKNLHFIK
NGDDNAAYNIGEKIRELPKKSDVKNTSISGNISFS
>ca38Cas12a2
MVEFCTGVKGMKSFENSCQISKTLRFGATLKEDKKKCKSHEELQEFVDISYKTMKSSATIAESLNEIELVKKCERCYSEI
IKFHEAWGQIYCRTDQIAVYKDFYRQLARKARFDVGDQNSQLITLSSLSSKHNVYQGLKRSQHITNYWKDNIARQKSFLK
DFSQQLHQYKRALENSDKAHTKPNLINFNKTFSILANLVNEIVIPLSNGAISFPNISKLEDGEESRHLIEFALNDYSDLV
GSIGELKDAIATNGGYTPFAKVTLNHYTAEQKPHVFKNDIDAKIRELKLIELVEKLKNKTSKQIEEYFSKFDKFKIYDDR
NQSVIIRTQCFKYKPIPFLVKHELAKYIAEDEDAVLKVLDAIGATRSPAHDYAHNEDVFDLKHYPIKVAFDYAWEQLANG
VYTTVSFPEEKCREYLNAIYGCEVTKEPVFKFYADLLYIRKNLAVLEHKNNLPSNPEEFICKIENTFEKIVLPYKIKEFE
TYKKAILTWINDGRGHEKYTDSKRELGLIRGGLKGRIGAQKMFRKNKKGELIPYYENPYTKLTNEFKNISSSYGKTFAEL
RDKFKEKSEITKITHFGIIIEDNNKDRYLLANGLQHDNTDQSNTQVEAILGKLNTSLEFTTYQVKSLTSKILIKLIKNHT
TSPNAKSPYADFHTSKIHVDWTKIKKEWDTYKSNHSLLQYVKDCLTNSTMAKNQNWAEFGWDLESCNSYEAIEHEIDQKS
YILQKHTISKASIKSLVENGCLLLPIVNQDITSQGRKDKNQFSKDWKQIFEDSKEYRLHPEFAVSYRTPIKDYPKDKRYG
RLQFICAFNCEIIPQNGEFINLKKQIENFNDEDIQKNNVAEFNNKVNEALLGKEYVVIGIDRGLKQLATLCVLNKRGKIL
GDFEIYKKEFVRTENRSKNYWKHTLAETRHILDLSNLRVETTVEDNKVLVDQSLTLVKKNRDTPDEKATEENRQKIKLKQ
LSYIRKLQYAMQTNEQAVLDLLKDNSDDEEFKKRVEGVISPFGEGQEYADLPIDTMRAMIQDLQGVIAKGNKQTEKNKII
ELDAADSLKQGVVANMIGVVNFILAKFNYEAYVSLEDLSRAYNVAKSGYDGRYLPSTSQDPDMDFKEQQNQMLAGLGTYQ
FFEIQLLKKLQKIQSNNTVLRFVPAFRSADNYRNIIKLNPKYDNTEYVHKPFGIVHFIDPKDTSSKCPVCGKTGKKNVDR
NEKKNNILLCKACAFRTVWEFKQPENIKNEKHCFSEDGIKKTAEDNNKKIKEKNLSDKNLHYIHNGDDNGAYHIALKSVE
NLKHKK
>ca41Cas12a2
MLTKFANLYELTKTVRFGLTPKNSYKKVSDFFELTEKSLESVQAEIVEREKEKINITSTEESIKKIRAYVDELKKQSAQW
KTIYQREDMIAVTKEYYKKLEKEAGFDGFWEDRGKKQPQTSEIMLSALSKEYNNKPRREYIITYWALLLQKTEQLNSYFE
PLLEKYEESLSRKEQAHLKPNLVDFRKQFLSLLNVSNKWLMPVINQSIVFPKIHNASKGEQNRKVKDFISEEGRQKRIQL
QSIGRSLRDFFEANGSRVPFGKATLNYFTARQKPNRFDSEIDALMLDLEIEEIVRKVKDLNGEELKNYFKYQTYATGDKL
DAFLGHSYMTLIEKIQLFKPKPIPASVRFSLAERLSKKMNLPMEKVTAIFDEIGNPIDIAREYEQALDQKNFDLNKYPIN
IAFDYAWESCASLIKGRISEGDFPKAQCLAILKKFNADGDDFKLYANLRYIRDELAPIEHNNPSADIEKELVYNIQKTIG
IIYSSMPSEYQKYLDIILKWVEMPKIERNSSDSNFIFAKQKIGLLRGGLKNKINKHAEITNKFKNLSMAFGRSCSDLRDK
LREEHELSKIKYYSVLIEDSKKNRHLLMLPLETGDQKMSAVEIENRLDILENKFVEDAPSANAYIASKVSSFTSKALVKM
LKNPKGSEDFHIGSEKYKLHDYNNKIKKEWKIYQDDSKFLSYAKKCLSESKMAMNQHWEKFGWNFEGCKTYADLEKEVDI
KGYSLEKKYISFENTEMLVYEQGCLLFPIVNQDYASEVCQNIFTGNKNAFTIEIEKGLQEQDGYLIHPEFTIFYQKPTED
YKKSNRYGRFQLSANFSLEVKKISDNFKTKKEKLKNIRDKDSFQKDVQIFNESINAQLRINEDVYFYGIDRGINELATLC
LLNNKNKIQDFIVFKKEKKKRNSENHLREAGDFYTYVDFEKQNILDLTNIKVETWNMRDEIHPNSNFLKQAFKKIEADPE
MKMIATQLGYGINEKKQCTILVEYPSDRSNTLKLRMNHFQRALQFATSHSEKRDIVGGIAERNFEGTDLENPSDEVKKQI
IQDLFGLGSDFLIDEKKAGVINELQTKKFRFEKIYSRNQQLFLEMFEPLIQQLIEWYQHKNDPDYEKTGKAKYEEMEDLD
TLKRGVTANMVGVFSFLMQKFPGVIVLENIAKEKLEKPVQSKLDEHTREVESHQEAEHHRWAGVELYRYMEKKLVQKFSN
WRQPTGEIFNLTPPFANLESLNKQTMTINSERIENMFQFGIFCYTPAEYTTKTCPCCNKYHIRNRKKGNTFDSIICKNEH
CGFDTRYNEPLHESFNPARNVEIALRLNPEFSEALPKIRSGDQSAAFNIAKKGLIIMENKLC
>ca125Cas12a2
MGKKQAVYNKFDEYLNQKNNSGKSNSNQIFNNNRQRRDKQAKNPKNNHAGKGDDAKPQIIKIPKSAIFEQYKTIRFTLSP
NETKKNKVVASELESLVGVSMEMVQSQIQEKSKSLEIKDQETAIKKINEILGSLKNFTSSWLTFSERTDTIKLSEEYYRF
VARKARFNSFEQYKDKYGKEKTTPQIKSGFIPLNQKSEYQGIERSEYVIKYWQNLANNIVNLHSQLEAPVDKYITALEKQ
DKAHTKVNLIQLKKTFLSFSNLILEYLEPLTNNKILIEKIDKLPDSEENTKLKEFFSNQNINLIRQDLQSLKQVIDYFNQ
NGALVSLGKVSLNYHTAVKKPDIVKSEIETIINELELETFIKKYIQCDDQELFKKFQFDIADKKQVFLCNKNDLTKIELA
QLFKPRPIPFGVIHEISEYFEKKDFDYNNVQNILMNTGQSVNIAGDWTNTKLEDRENFDLNKYPLKSAFDYAWEYTARNK
VGLIGNNDFAKKQSEKLLTDFDVKTSDNNFESYANLLFIGDKLAVLEHSAHEIKDKKELENIMILISQKIENVKNPFHQN
SEKDRYEKFENNCETISSSLNSSHTLKSNKNFQKAKQNLGLVRGGLKNKGIYYKLTQQFGINKTIDNKLSLASFLGLKFA
DLNKKFKEKYENNKIGYYGVIVEENINKYLLLKALENEDTREIIENDKILKSEKFENALTVKKVTSLTSNSLKKIRINKK
AYPDFHLEKIDEEKTSKEDNKALKESKRANYIKRCLLKSKMSQEQNWNQKFNWENDLNECQTYEQIEKVLDLKGYKLETK
HISKNDLENLVTEQDCLLLPIINQDYQSEIKQGEFVGNKNQFTVDFENVFVNKPIENKQDKKTYNYRIHPEFSLFYQLPT
IKPETGQTEQDLQKEHHAKTLNRNSRFQIIGNFGIEIKPEITEFSQFGNFINRKGKNDLTRDKQSYAEFVQGFNQKISSD
FEQKDSNRQWIYGFDRGINELATLCVLHKNSKQIDDFVVFKKEKEKEKKLGWIGEIIEEKKKSGKELEKKDKFVFRFVKH
DESKNQKGFELQHILDLTNIKVETWHFGFKDKDGNDHPNDKYLKTALSKIKENSELFEIAKKLGYFDNFSEGKRGENIKI
LVQYPENESNVIKLRMNHFQRVLSFAISQNRDGVANSIEEVFESDVEAEQVKKLFDNGILDNTKIKIDIDKHINLFKPLL
DQIKEWNENKDKPNYLDEFKKKYEEIEDLDTLKKGIVANMVGVTGFLMEKLPGVLVLEDTYKYDPQGFRINSLTKRDENA
DTFGHSEHLTWAGTETYRYFEKMLVKKFVKQRLVPPFADLESLNTQKTKLGGNEDENNKQFGIMFYVDAGFTSKTCPCCG
FKPDFKNENLKNLLEKTTSIQKINHNYCLSDCKDNILFELKN
>EcCas12a
MIKDNFVNVYSLSKTIRMALIPWGKTEDNFYKKFLLEEDEERAKNYIKVKGYMDEYHKNFIESALNSVVLNGVDEYCELY
FKQNKSDSEVKKIESLEASMRKQISKAMKEYTVDGVKIYPLLSKKEFIRELLPEFLTQDEEIETLEQFNDFSTYFQGFWE
NRKNIYTDEEKSTGVPYRCINDNLPKFLDNVKSFEKVILALPQKAVDELNANFNGVYNVDVQDVFSVDYFNFVLSQSGIE
KYNNIIGGYSNSDASKVQGLNEKINLYNQQIAKSDKSKKLPLLKPLYKQILSDRSSLSFIPEKFKDDNEVLNSINVLYDN
IAESLEKANDLMSDIANYNTDNIFISSGVAVTDISKKVFGDWSLIRNNWNDEYESTHKKGKNEEKFYEKEDKEFKKIKSF
SVSELQRLANSDLSIVDYLVDESASLYADIKTAYNNAKDLLSNEYSHSKRLSKNDDAIELIKSFLDSIKNYEAFLKPLCG
TGKEESKDNAFYGAFLECFEEIRQVDAVYNKVRNHITQKPYSNDKIKLNFQNPQFLAGWDKNKERAYRSVLLRNGEKYYL
AIMEKGKSKLFEDFPEDESSPFEKIDYKLLPEPSKMLPKVFFATSNKDLFNPSDEILNIRATGSFKKGDSFNLDDCHKFI
DFYKASIENHPDWSKFDFDFSETNDYEDISKFFKEVSDQGYSIGYRKISESYLEEMVDNGSLYMFQLYNKDFSENRKSKG
TPNLHTLYFKMLFDERNLEDVVYKLSGGAEMFYRKPSIDKNEMIVHPKNQPIDNKNPNNVKKTSTFEYDIVKDMRYTKPQ
FQLHLPIVLNFKANSKGYINDDVRNVLKNSEDTYVIGIDRGERNLVYACVVDGNGKLVEQVPLNVIEADNGYKTDYHKLL
NDREEKRNEARKSWKTIGNIKELKEGYISQVVHKICQLVVKYDAVIAMEDLNSGFVNSRKKVEKQVYQKFERMLTQKLNY
LVDKKLDPNEMGGLLNAYQLTNEATKVRNGRQDGIIFYIPAWLTSKIDPTTGFVNLLKPKYNSVSASKEFFSKFDEIRYN
EKENYFEFSFNYDNFPKCNADFKREWTVCTYGDRIRTFRDPENNNKFNSEVVVLNDEFKNLFVEFDIDYTDNLKEQILAM
DEKSFYKKLMGLLSLTLQMRNSISKNVDVDYLISPVKNSNGEFYDSRNYDITSSLPCDADSNGAYNIARKGLWAINQIKQ
ADDETKANISIKNSEWLQYAQNCDEV
>FnCas12a
MSIYQEFVNKYSLSKTLRFELIPQGKTLENIKARGLILDDEKRAKDYKKAKQIIDKYHQFFIEEILSSVCISEDLLQNYS
DVYFKLKKSDDDNLQKDFKSAKDTIKKQISEYIKDSEKFKNLFNQNLIDAKKGQESDLILWLKQSKDNGIELFKANSDIT
DIDEALEIIKSFKGWTTYFKGFHENRKNVYSSNDIPTSIIYRIVDDNLPKFLENKAKYESLKDKAPEAINYEQIKKDLAE
ELTFDIDYKTSEVNQRVFSLDEVFEIANFNNYLNQSGITKFNTIIGGKFVNGENTKRKGINEYINLYSQQINDKTLKKYK
MSVLFKQILSDTESKSFVIDKLEDDSDVVTTMQSFYEQIAAFKTVEEKSIKETLSLLFDDLKAQKLDLSKIYFKNDKSLT
DLSQQVFDDYSVIGTAVLEYITQQIAPKNLDNPSKKEQELIAKKTEKAKYLSLETIKLALEEFNKHRDIDKQCRFEEILA
NFAAIPMIFDEIAQNKDNLAQISIKYQNQGKKDLLQASAEDDVKAIKDLLDQTNNLLHKLKIFHISQSEDKANILDKDEH
FYLVFEECYFELANIVPLYNKIRNYITQKPYSDEKFKLNFENSTLANGWDKNKEPDNTAILFIKDDKYYLGVMNKKNNKI
FDDKAIKENKGEGYKKIVYKLLPGANKMLPKVFFSAKSIKFYNPSEDILRIRNHSTHTKNGSPQKGYEKFEFNIEDCRKF
IDFYKQSISKHPEWKDFGFRFSDTQRYNSIDEFYREVENQGYKLTFENISESYIDSVVNQGKLYLFQIYNKDFSAYSKGR
PNLHTLYWKALFDERNLQDVVYKLNGEAELFYRKQSIPKKITHPAKEAIANKNKDNPKKESVFEYDLIKDKRFTEDKFFF
HCPITINFKSSGANKFNDEINLLLKEKANDVHILSIDRGERHLAYYTLVDGKGNIIKQDTFNIIGNDRMKTNYHDKLAAI
EKDRDSARKDWKKINNIKEMKEGYLSQVVHEIAKLVIEYNAIVVFEDLNFGFKRGRFKVEKQVYQKLEKMLIEKLNYLVF
KDNEFDKTGGVLRAYQLTAPFETFKKMGKQTGIIYYVPAGFTSKICPVTGFVNQLYPKYESVSKSQEFFSKFDKICYNLD
KGYFEFSFDYKNFGDKAAKGKWTIASFGSRLINFRNSDKNHNWDTREVYPTKELEKLLKDYSIEYGHGECIKAAICGESD
KKFFAKLTSVLNTILQMRNSKTGTELDYLISPVADVNGNFFDSRQAPKNMPQDADANGAYHIGLKGLMLLGRIKNNQEGK
KLNLVIKNEEYFEFVQNRNN
>KaCas12a
MNVKKSPTTFAEFTNQYSLSKTLRFELKPVGNTQKMLEDFGIIEKDEIIAQKYKITKKYFDKLHRTFVEEALFGKKIEGL
DNYFELYRNWKKDKKANQKDLQNKETELRKNIVTLFNKMAKTWSQKETFKGLKNNNIEILFEEAVFKSVLKVLYGDEDES
FLRDKVSGEFLLDKDGNKISVFDSWKGFTGYFTKFNETRKNFYKDDGTATAHATRIIDQNLKRFCENIIIFESIKDKLDL
SEVENVFDISLVDIFSVTNYGDCFLQAGIDSYNTVLGGETLPNGEKKKGLNELINLYKQQTREKLPFFKSLDKQILSEKD
KFTDEIEDAGALKEVLTVFLKNVDVKIQKFSLLITDVLNNPDAYDLSQIYLAKEALNTISRRWLVSFSTFEDALYTVLKN
AKIISSSAKKTEGGYSFPEFIPLSYLKEALEKMVEDKIWKEQFYVTVEGLKNNGVIIGNKPVWQQFWEIYRFEFEQLKSR
IEIDSQIGTTHPAGYSVSKTALETILKDFKEDDVAPKLAIKNLADDVLHIYQLAKYFAIEKKIEKKRRWEGDNFELDVFY
TNPDFGYFETFYKNAYEDIVQVYNKLRNYLTKKPYSQEKWKLNFDNPTLAAGWDKNKEADNSAVLLKKDGKYYLGLMEKS
HNRIFDKKHEALFLDNNQSENYEKVVYKFFPDQAKMFPKVCFSVKGLDFFKPSEEIYKIYKNAEFKKGDTFSIKSMQSLI
KFYIDCLQKYDGWKGYNFKHIKSSNQYTNNIGDFFRDVAEDGYKITYQDVSDSYIKEKNNNGELYLFQIKNQDWNLDKAI
NGIKKTTTKNLHTLYFEALFSKENAEQNFPIKLNGQAEIFYRPKTSQGKLGTKLVNNKEVVNHKRYSEDKIFFHVPLTLN
RTKNRTKNEAQKFNSKVNEFLVNNPNINIIGIDRGEKHLAYYSVINQQGEILSDAKGIPAIGSLNFVGQGADGKEIDYAE
KLAIRASERESSRRDWLDIEKIKDLKKGYISQVVRKLADLAIEHNAIIVLEDLNMRFKQIRGGIEKSIYQQLEKALIEKL
SFLVDKGETDPEKAGHLFRAYQLTAPFESFQNIGKQTGIIFYTQANYTSKTCPECGFRPNVRFDESIDWNLINIKYYDND
FTISYSLKTFTKAKETSKRSNQLFTGINKKDSFILSTKNAIRYKWFRRNISAVELSAGESKLINETGSGVTIQYQLTDCM
KGLFEGNGIDIKGNINSQLRTGGHLMKFYKQLANYLYLLSNTRSSVSGTDIDIINCPCCGFDSTQGFKGVAYNGDANGAY
NIGRKGLIVLDKIKNYQKNNGPLEKMNWGDIFIDIDEWDKFTQK
>Lb2Cas12a
MHENNGKIADNFIGIYPVSKTLRFELKPVGKTQEYIEKHGILDEDLKRAGDYKSVKKIIDAYHKYFIDEALNGIQLDGLK
NYYELYEKKRDNNEEKEFQKIQMSLRKQIVKRFSEHPQYKYLFKKELIKNVLPEFTKDNAEEQTLVKSFQEFTTYFEGFH
QNRKNMYSDEEKSTAIAYRVVHQNLPKYIDNMRIFSMILNTDIRSDLTELFNNLKTKMDITIVEEYFAIDGFNKVVNQKG
IDVYNTILGAFSTDDNTKIKGLNEYINLYNQKNKAKLPKLKPLFKQILSDRDKISFIPEQFDSDTEVLEAVDMFYNRLLQ
FVIENEGQITISKLLTNFSAYDLNKIYVKNDTTISAISNDLFDDWSYISKAVRENYDSENVDKNKRAAAYEEKKEKALSK
IKMYSIEELNFFVKKYSCNECHIEGYFERRILEILDKMRYAYESCKILHDKGLINNISLCQDRQAISELKDFLDSIKEVQ
WLLKPLMIGQEQADKEEAFYTELLRIWEELEPITLLYNKVRNYVTKKPYTLEKVKLNFYKSTLLDGWDKNKEKDNLGIIL
LKDGQYYLGIMNRRNNKIADDAPLAKTDNVYRKMEYKLLTKVSANLPRIFLKDKYNPSEEMLEKYEKGTHLKGENFCIDD
CRELIDFFKKGIKQYEDWGQFDFKFSDTESYDDISAFYKEVEHQGYKITFRDIDETYIDSLVNEGKLYLFQIYNKDFSPY
SKGTKNLHTLYWEMLFSQQNLQNIVYKLNGNAEIFYRKASINQKDVVVHKADLPIKNKDPQNSKKESMFDYDIIKDKRFT
CDKYQFHVPITMNFKALGENHFNRKVNRLIHDAENMHIIGIDRGERNLIYLCMIDMKGNIVKQISLNEIISYDKNKLEHK
RNYHQLLKTREDENKSARQSWQTIHTIKELKEGYLSQVIHVITDLMVEYNAIVVLEDLNFGFKQGRQKFERQVYQKFEKM
LIDKLNYLVDKSKGMDEDGGLLHAYQLTDEFKSFKQLGKQSGFLYYIPAWNTSKLDPTTGFVNLFYTKYESVEKSKEFIN
NFTSILYNQEREYFEFLFDYSAFTSKAEGSRLKWTVCSKGERVETYRNPKKNNEWDTQKIDLTFELKKLFNDYSISLLDG
DLREQMGKIDKADFYKKFMKLFALIVQMRNSDEREDKLISPVLNKYGAFFETGKNERMPLDADANGAYNIARKGLWIIEK
IKNTDVEQLDKVKLTISNKEWLQYAQEHIL
>LbCas12a
AASKLEKFTNCYSLSKTLRFKAIPVGKTQENIDNKRLLVEDEKRAEDYKGVKKLLDRYYLSFINDVLHSIKLKNLNNYIS
LFRKKTRTEKENKELENLEINLRKEIAKAFKGAAGYKSLFKKDIIETILPEAADDKDEIALVNSFNGFTTAFTGFFDNRE
NMFSEEAKSTSIAFRCINENLTRYISNMDIFEKVDAIFDKHEVQEIKEKILNSDYDVEDFFEGEFFNFVLTQEGIDVYNA
IIGGFVTESGEKIKGLNEYINLYNAKTKQALPKFKPLYKQVLSDRESLSFYGEGYTSDEEVLEVFRNTLNKNSEIFSSIK
KLEKLFKNFDEYSSAGIFVKNGPAISTISKDIFGEWNLIRDKWNAEYDDIHLKKKAVVTEKYEDDRRKSFKKIGSFSLEQ
LQEYADADLSVVEKLKEIIIQKVDEIYKVYGSSEKLFDADFVLEKSLKKNDAVVAIMKDLLDSVKSFENYIKAFFGEGKE
TNRDESFYGDFVLAYDILLKVDHIYDAIRNYVTQKPYSKDKFKLYFQNPQFMGGWDKDKETDYRATILRYGSKYYLAIMD
KKYAKCLQKIDKDDVNGNYEKINYKLLPGPNKMLPKVFFSKKWMAYYNPSEDIQKIYKNGTFKKGDMFNLNDCHKLIDFF
KDSISRYPKWSNAYDFNFSETEKYKDIAGFYREVEEQGYKVSFESASKKEVDKLVEEGKLYMFQIYNKDFSDKSHGTPNL
HTMYFKLLFDENNHGQIRLSGGAELFMRRASLKKEELVVHPANSPIANKNPDNPKKTTTLSYDVYKDKRFSEDQYELHIP
IAINKCPKNIFKINTEVRVLLKHDDNPYVIGIDRGERNLLYIVVVDGKGNIVEQYSLNEIINNFNGIRIKTDYHSLLDKK
EKERFEARQNWTSIENIKELKAGYISQVVHKICELVEKYDAVIALEDLNSGFKNSRVKVEKQVYQKFEKMLIDKLNYMVD
KKSNPCATGGALKGYQITNKFESFKSMSTQNGFIFYIPAWLTSKIDPSTGFVNLLKTKYTSIADSKKFISSFDRIMYVPE
EDLFEFALDYKNFSRTDADYIKKWKLYSYGNRIRIFAAAKKNNVFAWEEVCLTSAYKELFNKYGINYQQGDIRALLCEQS
DKAFYSSFMALMSLMLQMRNSITGRTDVDFLISPVKNSDGIFYDSRNYEAQENAILPKNADANGAYNIARKVLWAIGQFK
KAEDEKLDKVKIAISNKEWLEYAQTSVK
>LsaCas12b1
MSIRSFKLKLKTKSGVNAEQLRRGLWRTHQLINDGIAYYMNWLVLLRQEDLFIRNKETNEIEKRSKEEIQAVLLERVHKQ
QQRNQWSGEVDEQTLLQALRQLYEEIVPSVIGKSGNASLKARFFLGPLVDPNNKTTKDVSKSGPTPKWKKMKDAGDPNWV
QEYEKYMAERQTLVRLEEMGLIPLFPMYTDEVGDIHWLPQASGYTRTWDRDMFQQAIERLLSWESWNRRVRERRAQFEKK
THDFASRFSESDVQWMNKLREYEAQQEKSLEENAFAPNEPYALTKKALRGWERVYHSWMRLDSAASEEAYWQEVATCQTA
MRGEFGDPAIYQFLAQKENHDIWRGYPERVIDFAELNHLQRELRRAKEDATFTLPDSVDHPLWVRYEAPGGTNIHGYDLV
QDTKRNLTLILDKFILPDENGSWHEVKKVPFSLAKSKQFHRQVWLQEEQKQKKREVVFYDYSTNLPHLGTLAGAKLQWDR
NFLNKRTQQQIEETGEIGKVFFNISVDVRPAVEVKNGRLQNGLGKALTVLTHPDGTKIVTGWKAEQLEKWVGESGRVSSL
GLDSLSEGLRVMSIDLGQRTSATVSVFEITKEAPDNPYKFFYQLEGTEMFAVHQRSFLLALPGENPPQKIKQMREIRWKE
RNRIKQQVDQLSAILRLHKKVNEDERIQAIDKLLQKVASWQLNEEIATAWNQALSQLYSKAKENDLQWNQAIKNAHHQLE
PVVGKQISLWRKDLSTGRQGIAGLSLWSIEELEATKKLLTRWSKRSREPGVVKRIERFETFAKQIQHHINQVKENRLKQL
ANLIVMTALGYKYDQEQKKWIEVYPACQVVLFENLRSYRFSFERSRRENKKLMEWSHRSIPKLVQMQGELFGLQVADVYA
AYSSRYHGRTGAPGIRCHALTEADLRNETNIIHELIEAGFIKEEHRPYLQQGDLVPWSGGELFATLQKPYDNPRILTLHA
DINAAQNIQKRFWHPSMWFRVNCESVMEGEIVTYVPKNKTVHKKQGKTFRFVKVEGSDVYEWAKWSKNRNKNTFSSITER
KPPSSMILFRDPSGTFFKEQEWVEQKTFWGKVQSMIQAYMKKTIVQRMEE
>LseCas12b1
MSIRSFKLKIKTKSGVNAEELRRGLWRTHQLINDGIAYYMNWLVLLRQEDLFIRNEETNEIEKRSKEEIQGELLERVHKQ
QQRNQWSGEVDDQTLLQTLRHLYEEIVPSVIGKSGNASLKARFFLGPLVDPNNKTTKDVSKSGPTPKWKKMKDAGDPNWV
QEYEKYMAERQTLVRLEEMGLIPLFPMYTDEVGDIHWLPQASGYTRTWDRDMFQQAIERLLSWESWNRRVRERRAQFEKK
THDFASRFSESDVQWMNKLREYEAQQEKSLEENAFAPNEPYALTKKALRGWERVYHSWMRLDSAASEEAYWQEVATCQTA
MRGEFGDPAIYQFLAQKENHDIWRGYPERVIDFAELNHLQRELRRAKEDATFTLPDSVDHPLWVRYEAPGGTNIHGYDLV
QDTKRNLTLILDKFILPDENGSWHEVKKVPFSLAKSKQFHRQVWLQEEQKQKKREVVFYDYSTNLPHLGTLAGAKLQWDR
NFLNKRTQQQIEETGEIGKVFFNISVDVRPAVEVKNGRLQNGLGKALTVLTHPDGTKIVTGWKAEQLEKWVGESGRVSSL
GLDSLSEGLRVMSIDLGQRTSATVSVFEITKEAPDNPYKFFYQLEGTELFAVHQRSFLLALPGENPPQKIKQMREIRWKE
RNRIKQQVDQLSAILRLHKKVNEDERIQAIDKLLQKVASWQLNEEIATAWNQALSQLYSKAKENDLQWNQAIKNAHHQLE
PVVGKQISLWRKDLSTGRQGIAGLSLWSIEELEATKKLLTRWSKRSREPGVVKRIERFETFAKQIQHHINQVKENRLKQL
ANLIVMTALGYKYDQEQKKWIEVYPACQVVLFENLRSYRFSYERSRRENKKLMEWSHRSIPKLVQMQGELFGLQVADVYA
AYSSRYHGRTGAPGIRCHALTEADLRNETNIIHELIEAGFIKEEHRPYLQQGDLVPWSGGELFATLQKPYDNPRILTLHA
DINAAQNIQKRFWHPSMWFRVNCESVMEGEIVTYVPKNKTVHKKQGKTFRFVKVEGSDVYEWAKWSKNRNKNTFSSITER
KPPSSMILFRDPSGTFFKEQEWVEQKTFWGKVQSMIQAYMKKTIVQRMEE
>MaCas12a
MDAKEFTGQYPLSKTLRFELRPIGRTWDNLEASGYLAEDRHRAECYPRAKELLDDNHRAFLNRVLPQIDMDWHPIAEAFC
KVHKNPGNKELAQDYNLQLSKRRKEISAYLQDADGYKGLFAKPALDEAMKIAKENGNESDIEVLEAFNGFSVYFTGYHES
RENIYSDEDMVSVAYRITEDNFPRFVSNALIFDKLNESHPDIISEVSGNLGVDDIGKYFDVSNYNNFLSQAGIDDYNHII
GGHTTEDGLIQAFNVVLNLRHQKDPGFEKIQFKQLYKQILSVRTSKSYIPKQFDNSKEMVDCICDYVSKIEKSETVERAL
KLVRNISSFDLRGIFVNKKNLRILSNKLIGDWDAIETALMHSSSSENDKKSVYDSAEAFTLDDIFSSVKKFSDASAEDIG
NRAEDICRVISETAPFINDLRAVDLDSLNDDGYEAAVSKIRESLEPYMDLFHELEIFSVGDEFPKCAAFYSELEEVSEQL
IEIIPLFNKARSFCTRKRYSTDKIKVNLKFPTLADGWDLNKERDNKAAILRKDGKYYLAILDMKKDLSSIRTSDEDESSF
EKMEYKLLPSPVKMLPKIFVKSKAAKEKYGLTDRMLECYDKGMHKSGSAFDLGFCHELIDYYKRCIAEYPGWDVFDFKFR
ETSDYGSMKEFNEDVAGAGYYMSLRKIPCSEVYRLLDEKSIYLFQIYNKDYSENAHGNKNMHTMYWEGLFSPQNLESPVF
KLSGGAELFFRKSSIPNDAKTVHPKGSVLVPRNDVNGRRIPDSIYRELTRYFNRGDCRISDEAKSYLDKVKTKKADHDIV
KDRRFTVDKMMFHVPIAMNFKAISKPNLNKKVIDGIIDDQDLKIIGIDRGERNLIYVTMVDRKGNILYQDSLNILNGYDY
RKALDVREYDNKEARRNWTKVEGIRKMKEGYLSLAVSKLADMIIENNAIIVMEDLNHGFKAGRSKIEKQVYQKFESMLIN
KLGYMVLKDKSIDQSGGALHGYQLANHVTTLASVGKQCGVIFYIPAAFTSKIDPTTGFADLFALSNVKNVASMREFFSKM
KSVIYDKAEGKFAFTFDYLDYNVKSECGRTLWTVYTVGERFTYSRVNREYVRKVPTDIIYDALQKAGISVEGDLRDRIAE
SDGDTLKSIFYAFKYALDMRVENREEDYIQSPVKNASGEFFCSKNAGKSLPQDSDANGAYNIALKGILQLRMLSEQYDPN
AESIRLPLITNKAWLTFMQSGMKTWKN
>Mb1Cas12a
MLFQDFTHLYPLSKTVRFELKPIDRTLEHIHAKNFLSQDETMADMHQKVKVILDDYHRDFIADMMGEVKLTKLAEFYDVY
LKFRKNPKDDELQKQLKDLQAVLRKEIVKPIGNGGKYKAGYDRLFGAKLFKDGKELGDLAKFVIAQEGESSPKLAHLAHF
EKFSTYFTGFHDNRKNMYSDEDKHTAIAYRLIHENLPRFIDNLQILTTIKQKHSALYDQIINELTASGLDVSLASHLDGY
HKLLTQEGITAYNTLLGGISGEAGSPKIQGINELINSHHNQHCHKSERIAKLRPLHKQILSDGMSVSFLPSKFADDSEMC
QAVNEFYRHYADVFAKVQSLFDGFDDHQKDGIYVEHKNLNELSKQAFGDFALLGRVLDGYYVDVVNPEFNERFAKAKTDN
AKAKLTKEKDKFIKGVHSLASLEQAIEHYTARHDDESVQAGKLGQYFKHGLAGVDNPIQKIHNNHSTIKGFLERERPAGE
RALPKIKSGKNPEMTQLRQLKELLDNALNVAHFAKLLTTKTTLDNQDGNFYGEFGVLYDELAKIPTLYNKVRDYLSQKPF
STEKYKLNFGNPTLLNGWDLNKEKDNFGVILQKDGCYYLALLDKAHKKVFDNAPNTGKSIYQKMIYKYLEVRKQFPKVFF
SKEAIAINYHPSKELVEIKDKGRQRSDDERLKLYRFILECLKIHPKYDKKFEGAIGDIQLFKKDKKGREVPISEKDLFDK
INGIFSSKPKLEMEDFFIGEFKRYNPSQDLVDQYNIYKKIDSNDNRKKENFYNNHPKFKKDLVRYYYESMCKHEEWEESF
EFSKKLQDIGCYVDVNELFTEIETRRLNYKISFCNINADYIDELVEQGQLYLFQIYNKDFSPKAHGKPNLHTLYFKALFS
EDNLADPIYKLNGEAQIFYRKASLDMNETTIHRAGEVLENKNPDNPKKRQFVYDIIKDKRYTQDKFMLHVPITMNFGVQG
MTIKEFNKKVNQSIQQYDEVNVIGIDRGERHLLYLTVINSKGEILEQCSLNDITTASANGTQMTTPYHKILDKREIERLN
ARVGWGEIETIKELKSGYLSHVVHQISQLMLKYNAIVVLEDLNFGFKRGRFKVEKQIYQNFENALIKKLNHLVLKDKADD
EIGSYKNALQLTNNFTDLKSIGKQTGFLFYVPAWNTSKIDPETGFVDLLKPRYENIAQSQAFFGKFDKICYNADKDYFEF
HIDYAKFTDKAKNSRQIWTICSHGDKRYVYDKTANQNKGAAKGINVNDELKSLFARHHINEKQPNLVMDICQNNDKEFHK
SLMYLLKTLLALRYSNASSDEDFILSPVANDEGVFFNSALADDTQPQNADANGAYHIALKGLWLLNELKNSDDLNKVKLA
IDNQTWLNFAQNR
>Mb2Cas12a
MLFQDFTHLYPLSKTVRFELKPIGKTLEHIHAKNFLNQDETMADMYQKVKAILDDYHRDFIADMMGEVKLTKLAEFYDVY
LKFRKNPKDDGLQKQLKDLQAVLRKEIVKPIGNGGKYKAGYDRLFGAKLFKDGKELGDLAKFVIAQEGESSPKLAHLAHF
EKFSTYFTGFHDNRKNMYSDEDKHTAIAYRLIHENLPRFIDNLQILATIKQKHSALYDQIINELTASGLDVSLASHLDGY
HKLLTQEGITAYNTLLGGISGEAGSRKIQGINELINSHHNQHCHKSERIAKLRPLHKQILSDGMGVSFLPSKFADDSEVC
QAVNEFYRHYADVFAKVQSLFDGFDDYQKDGIYVEYKNLNELSKQAFGDFALLGRVLDGYYVDVVNPEFNERFAKAKTDN
AKAKLTKEKDKFIKGVHSLASLEQAIEHYTARHDDESVQAGKLGQYFKHGLAGVDNPIQKIHNNHSTIKGFLERERPAGE
RALPKIKSDKSPEIRQLKELLDNALNVAHFAKLLTTKTTLHNQDGNFYGEFGALYDELAKIATLYNKVRDYLSQKPFSTE
KYKLNFGNPTLLNGWDLNKEKDNFGVILQKDGCYYLALLDKAHKKVFDNAPNTGKSVYQKMIYKLLPGPNKMLPKVFFAK
SNLDYYNPSAELLDKYAQGTHKKGDNFNLKDCHALIDFFKAGINKHPEWQHFGFKFSPTSSYQDLSDFYREVEPQGYQVK
FVDINADYINELVEQGQLYLFQIYNKDFSPKAHGKPNLHTLYFKALFSEDNLVNPIYKLNGEAEIFYRKASLDMNETTIH
RAGEVLENKNPDNPKKRQFVYDIIKDKRYTQDKFMLHVPITMNFGVQGMTIKEFNKKVNQSIQQYDEVNVIGIDRGERHL
LYLTVINSKGEILEQRSLNDITTASANGTQMTTPYHKILDKREIERLNARVGWGEIETIKELKSGYLSHVVHQISQLMLK
YNAIVVLEDLNFGFKRGCFKVEKQIYQNFENALIKKLNHLVLKDKADDEIGSYKNALQLTNNFTDLKSIGKQTGFLFYVP
AWNTSKIDPETGFVDLLKPRYENIAQSQAFFGKFDKICYNADRGYFEFHIDYAKFNDKAKNSRQIWKICSHGDKRYVYDK
TANQNKGATIGVNVNDELKSLFTRYHINDKQPNLVMDICQNNDKEFHKSLMYLLKTLLALRYSNASSDEDFILSPVANDE
GVFFNSALADDTQPQNADANGAYHIALKGLWLLNELKNSDDLNKVKLAIDNQTWLNFAQNR
>Mb3Cas12a
MLFQDFTHLYPLSKTVRFELKPIGRTLEHIHAKNFLSQDETMADMYQKVKVILDDYHRDFIADMMGEVKLTKLAEFYDVY
LKFRKNPKDDELQKQLKDLQAVLRKESVKPIGNGGKYKAGHDRLFGAKLFKDGKELGDLAKFVIAQEGKSSPKLAHLAHF
EKFSTYFTGFHDNRKNMYSDEDKHTAIAYRLIHENLPRFIDNLQILTTIKQKHSALYDQIINELTASGLDVSLASHLDGY
HKLLTQEGITAYNRIIGEVNGYTNKHNQICHKSERIAKLRPLHKQILSDGMGVSFLPSKFADDSEMCQAVNEFYRHYTDV
FAKVQSLFDGFDDHQKDGIYVEHKNLNELSKQAFGDFALLGRVLDGYYVDVVNPEFNERFAKAKTDNAKAKLTKEKDKFI
KGVHSLASLEQAIEHHTARHDDESVQAGKLGQYFKHGLAGVDNPIQKIHNNHSTIKGFLERERPAGERALPKIKSGKNPE
MTQLRQLKELLDNALNVAHFAKLLTTKTTLDNQDGNFYGEFGVLYDELAKIPTLYNKVRDYLSQKPFSTEKYKLNFGNPT
LLNGWDLNKEKDNFGVILQKDGCYYLALLDKAHKKVFDNAPNTGKSIYQKMVYKYLEVRKQFPKVFFSKEAIAINYHPSK
ELVEIKDKGRQRSDDERLKLYRFILECLKIHPKYDKKFEGAIGDIQLFKKDKKGREVPISEKDLFDKINGIFSSKPKLEM
EDFFIGEFKRYNPSQDLVDQYNIYKKIDSNDNRKKENFYNNHPKFKKDLVRYYYESMCKHEEWEESFEFSKKLQDIGCYV
DVNELFTEIETRRLNYKISFCNINADYIDELVEQGKLYLFQIYNKDFSPKAHGKPNLHTLYFKALFSEDNLADPIYKLNG
EAQIFYRKASLDVNETTIHRAGEVLENKNPDNPKKRQFVYDIIKDKRYTQDKFMLHVPITMNFGVQGMTIKEFNKKVNQS
IQQYDEVNVIGIDRGERHLLYLTVINSKGEILEQRSLNDITTASANGTQMTTPYHKILDKREIERLNARVGWGEIETIKE
LKSGYLSHVVHQISQLMLKYNAIVVLEDLNFGFKRGRFKVEKQIYQNFENALIKKLNHLVLKDKADDEIGSYKNALQLTN
NFTDLKNIGKQTGFLFYVPAWNTSKIDPETGFVDLLKPRYENIAQSQAFFGKFDKICYNADKDYFEFHIDYAKFTDKAKN
SRQTWTICSHGDKRYVYDKTANQNKGATKGINVNDELKSLFARHHINDKQPNLVMDICQNNDKEFHKSLMYLLKTLLALR
YSNASSDEDFILSPVANDGGVFFNSALADDTQPQNADANGAYHIALKGLWLLNELKDSDDLNKVKLAIDNQTWLNFAQNR
>McCas12a
MLFQDFTHLYPLSKTMRFELKPIGKTLEHIHAKNFLSQDETMADMYQKVKAILDDYHRDFIADMMGEVKLTKLAEFYDVY
LKFRKNPKDDGLQKQLKDLQAVLRKEIVKPIGNGGKYKAGYDRLFGAKLFKDGKELGDLAKFVIAQEGESSPKLAHLAHF
EKFSTYFTGFHDNRKNMYSDEDKHTAITYRLIHENLPRFIDNLQILATIKQKHSALYDQIINELTASGLDVSLASHLDGY
HKLLTQEGITAYNTLLGGISGEAGSRKIQGINELINSHHNQHCHKSERIAKLRPLHKQILSDGMGVSFLPSKFADDSEMC
QAVNEFYRHYADVFAKVQSLFDGFDDHQKDGIYVEHKNLNELSKQAFGDFALLGRVLDGYYVDVVNPEFNERFAKAKTDN
AKAKLTKEKDKFIKGVHSLASLEQAIEHYTARHDDESVQAGKLGQYFKHGLAGVDNPIQKIHNNHSTIKGFLERERPAGE
RALPKIKSGKNPEMTQLRQLKELLDNALNVAHFAKLLTTKTTLDNQDGNFYGEFGALYDELAKIPTLYNKVRDYLSQKPF
STEKYKLNFGNPTLLNGWDLNKEKDNFGIILQKDGCYYLALLDKAHKKVFDNAPNTGKNVYQKMIYKLLPGPNKMLPKVF
FAKSNLDYYNPSAELLDKYAQGTHKKGNNFNLKDCHALIDFFKAGINKHPEWQHFGFKFSPTSSYQDLSDFYREVEPQGY
QVKFVDINADYINELVEQGQLYLFQIYNKDFSPKAHGKPNLHTLYFKALFSKDNLANPIYKLNGEAQIFYRKASLDMNET
TIHRAGEVLENKNPDNPKKRQFVYDIIKDKRYTQDKFMLHVPITMNFGVQGMTIKEFNKKVNQSIQQYDEVNVIGIDRGE
RHLLYLTVINSKGEILEQRSLNDITTASANGTQMTTPYHKILDKREIERLNARVGWGEIETIKELKSGYLSHVVHQISQL
MLKYNAIVVLEDLNFGFKRGRFKVEKQIYQNFENALIKKLNHLVLKDEADDEIGSYKNALQLTNNFTDLKSIGKQTGFLF
YVPAWNTSKIDPETGFVDLLKPRYENIAQSQAFFGKFDKICYNADKDYFEFHIDYAKFTDKAKNSRQIWKICSHGDKRYV
YDKTANQNKGATKGINVNDELKSLFARHHINDKQPNLVMDICQNNDKEFHKSLIYLLKTLLALRYSNASSDEDFILSPVA
NDEGMFFNSALADDTQPQNADANGAYHIALKGLWVLEQIKNSDDLNKVKLAIDNQTWLNFAQNR
>MlCas12a
MLFQDFTHLYPLSKTVRFELKPIGKTLEHIHAKNFLSQDETMADMYQKVKAILDDYHRDFITKMMSEVTLTKLPEFYEVY
LALRKNPKDDTLQKQLTEIQTALREEVVKPIDSGGKYKAGYERLFGAKLFKDGKELGDLAKFVIAQEGESSPKLPQIAHF
EKFSTYFTGFHDNRKNMYSSDDKHTAIAYRLIHENLPRFIDNLQILVTIKQKHSVLYDQIVNELNANGLDVSLASHLDGY
HKLLTQEGITAYNRIIGEVNSYTNKHNQICHKSERIAKLRPLHKQILSDGMGVSFLPSKFADDSEMCQAVNEFYRHYAHV
FAKVQSLFDRFDDYQKDGIYVEHKNLNELSKQAFGDFALLGRVLDGYYVDVVNPEFNDKFAKAKTDNAKEKLTKEKDKFI
KGVHSLASLEQAIEHYIAGHDDESVQAGKLGQYFKHGLAGVDNPIQKIHNSHSTIKGFLERERPAGERTLPKIKSDKSLE
MTQLRQLKELLDNALNVVHFAKLLTTKTTLDNQDGNFYGEFGALYDELAKIATLYNKVRDYLSQKPFSTEKYKLNFGNPT
LLNGWDLNKEKDNFGVILQKDGCYYLALLDKAHKKVFDNAPNTGKSVYQKMVYKLLPGPNKMLPKVFFAKSNLDYYNPSA
ELLDKYAQGTHKKGDNFNLKDCHALIDFFKASINKHPEWQHFGFEFSLTSSYQDLSDFYREVEPQGYQVKFVDIDADYID
ELVEQGQLYLFQIYNKDFSPKAHGKPNLHTLYFKALFSEDNLANPIYKLNGEAEIFYRKASLDMNETTIHRAGEVLENKN
PDNPKERQFVYDIIKDKRYTQDKFMLHVPITMNFGVQGMTIKEFNKKVNQSIQQYDEVNVIGIDRGERHLLYLTVINSKG
EILEQRSLNDIITTSANGTQMTTPYHKILDKREIERLNARVGWGEIETIKELKSGYLSHVVHQISQLMLKYNAIVVLEDL
NFGFKRGRFKVEKQIYQNFENALIKKLNHLVLKDKADNEIGSYKNALQLTNNFTDLKSIGKQTGFLFYVPAWNTSKIDPV
TGFVDLLKPRYENIAQSQAFFDKFDKICYNADKGYFEFHIDYAKFTDKAKNSRQIWTICSHGDKRYVYDKTANQNKGATI
GINVNDELKSLFARYRINDKQPNLVMDICQNNDKEFHKSLTYLLKALLALRYSNASSDEDFILSPVANDKGVFFNSALAD
DTQPQNADANGAYHIALKGLWLLNELKNSDDLDKVKLAIDNQTWLNFAQNR
>Pb2Cas12a
MKFTDFTGLYSLSKTLRFELKPIGKTLENIKKAGLLEQDQHRADSYKKVKKIIDEYHKAFIEKSLSNFELKYQSEDKLDS
LEEYLMYYSMKRIEKTEKDKFAKIQDNLRKQIADHLKGDESYKTIFSKDLIRKNLPDFVKSDEERTLIKEFKDFTTYFKG
FYENRENMYSAEDKSTAISHRIIHENLPKFVDNINAFSKIILIPELREKLNQIYQDFEEYLNVESIDEIFHLDYFSMVMT
QKQIEVYNAIIGGKSTNDKKIQGLNEYINLYNQKHKDCKLPKLKLLFKQILSDRIAISWLPDNFKDDQEALDSIDTCYKN
LLNDGNVLGEGNLKLLLENIDTYNLKGIFIRNDLQLTDISQKMYASWNVIQDAVILDLKKQVSRKKKESAEDYNDRLKKL
YTSQESFSIQYLNDCLRAYGKTENIQDYFAKLGAVNNEHEQTINLFAQVRNAYTSVQAILTTPYPENANLAQDKETVALI
KNLLDSLKRLQRFIKPLLGKGDESDKDERFYGDFTPLWETLNQITPLYNMVRNYMTRKPYSQEKIKLNFENSTLLGGWDL
NKEHDNTAIILRKNGLYYLAIMKKSANKIFDKDKLDNSGDCYEKMVYKLLPGANKMLPKVFFSKSRIDEFKPSENIIENY
KKGTHKKGANFNLADCHNLIDFFKSSISKHEDWSKFNFHFSDTSSYEDLSDFYREVEQQGYSISFCDVSVEYINKMVEKG
DLYLFQIYNKDFSEFSKGTPNMHTLYWNSLFSKENLNNIIYKLNGQAEIFFRKKSLNYKRPTHPAHQAIKNKNKCNEKKE
SIFDYDLVKDKRYTVDKFQFHVPITMNFKSTGNTNINQQVIDYLRTEDDTHIIGIDRGERHLLYLVVIDSHGKIVEQFTL
NEIVNEYGGNIYRTNYHDLLDTREQNREKARESWQTIENIKELKEGYISQVIHKITDLMQKYHAVVVLEDLNMGFMRGRQ
KVEKQVYQKFEEMLINKLNYLVNKKADQNSAGGLLHAYQLTSKFESFQKLGKQSGFLFYIPAWNTSKIDPVTGFVNLFDT
RYESIDKAKAFFGKFDSIRYNADKDWFEFAFDYNNFTTKAEGTRTNWTICTYGSRIRTFRNQAKNSQWDNEEIDLTKAYK
AFFAKHGINIYDNIKEAIAMETEKSFFEDLLHLLKLTLQMRNSITGTTTDYLISPVHDSKGNFYDSRICDNSLPANADAN
GAYNIARKGLMLIQQIKDSTSSNRFKFSPITNKDWLIFAQEKPYLND
>PsCas12a
MENFKNLYPINKTLRFELRPYGKTLENFKKSGLLEKDAFKANSRRSMQAIIDEKFKETIEERLKYTEFSECDLGNMTSKD
KKITDKAATNLKKQVILSFDDEIFNNYLKPDKNIDALFKNDPSNPVISTFKGFTTYFVNFFEIRKHIFKGESSGSMAYRI
IDENLTTYLNNIEKIKKLPEELKSQLEGIDQIDKLNNYNEFITQSGITHYNEIIGGISKSENVKIQGINEGINLYCQKNK
VKLPRLTPLYKMILSDRVSNSFVLDTIENDTELIEMISDLINKTEISQDVIMSDIQNIFIKYKQLGNLPGISYSSIVNAI
CSDYDNNFGDGKRKKSYENDRKKHLETNVYSINYISELLTDTDVSSNIKMRYKELEQNYQVCKENFNATNWMNIKNIKQS
EKTNLIKDLLDILKSIQRFYDLFDIVDEDKNPSAEFYTWLSKNAEKLDFEFNSVYNKSRNYLTRKQYSDKKIKLNFDSPT
LAKGWDANKEIDNSTIIMRKFNNDRGDYDYFLGIWNKSTPANEKIIPLEDNGLFEKMQYKLYPDPSKMLPKQFLSKIWKA
KHPTTPEFDKKYKEGRHKKGPDFEKEFLHELIDCFKHGLVNHDEKYQDVFGFNLRNTEDYNSYTEFLEDVERCNYNLSFN
KIADTSNLINDGKLYVFQIWSKDFSIDSKGTKNLNTIYFESLFSEENMIEKMFKLSGEAEIFYRPASLNYCEDIIKKGHH
HAELKDKFDYPIIKDKRYSQDKFFFHVPMVINYKSEKLNSKSLNNRTNENLGQFTHIIGIDRGERHLIYLTVVDVSTGEI
VEQKHLDEIINTDTKGVEHKTHYLNKLEEKSKTRDNERKSWEAIETIKELKEGYISHVINEIQKLQEKYNALIVMENLNY
GFKNSRIKVEKQVYQKFETALIKKFNYIIDKKDPETYIHGYQLTNPITTLDKIGNQSGIVLYIPAWNTSKIDPVTGFVNL
LYADDLKYKNQEQAKSFIQKIDNIYFENGEFKFDIDFSKWNNRYSISKTKWTLTSYGTRIQTFRNPQKNNKWDSAEYDLT
EEFKLILNIDGTLKSQDVETYKKFMSLFKLMLQLRNSVTGTDIDYMISPVTDKTGTHFDSRENIKNLPADADANGAYNIA
RKGIMAIENIMNGISDPLKISNEDYLKYIQNQQE
>Rb1Cas12a
MKSFDSFTNLYSLSKTLKFEMRPVGNTQKMLDNAGVFEKDKLIQKKYGKTKPYFDRLHREFIEEALTGVELIGLDENFRT
LVDWQKDKKNNVAMKAYENSLQRLRTEIGKIFNLKAEDWVKNKYPILGLKNKNTDILFEEAVFGILKARYGEEKDTFIEV
EEIDKTGKSKINQISIFDSWKGFTGYFKKFFETRKNFYKNDGTSTAIATRIIDQNLKRFIDNLSIVESVRQKVDLAETEK
SFSISLSQFFSIDFYNKCLLQDGIDYYNKIIGGETLKNGEKLIGLNELINQYRQNNKDQKIPFFKLLDKQILSEKILFLD
EIKNDTELIEALSQFAKTAEEKTKIVKKLFADFVENNSKYDLAQIYISQEAFNTISNKWTSETETFAKYLFEAMKSGKLA
KYEKKDNSYKFPDFIALSQMKSALLSISLEGHFWKEKYYKISKFQEKTNWEQFLAIFLYEFNSLFSDKINTKDGETKQVG
YYLFAKDLHNLILSEQIDIPKDSKVTIKDFADSVLTIYQMAKYFAVEKKRAWLAEYELDSFYTQPDTGYLQFYDNAYEDI
VQVYNKLRNYLTKKPYSEEKWKLNFENSTLANGWDKNKESDNSAVILQKGGKYYLGLITKGHNKIFDDRFQEKFIVGIEG
GKYEKIVYKFFPDQAKMFPKVCFSAKGLEFFRPSEEILRIYNNAEFKKGETYSIDSMQKLIDFYKDCLTKYEGWACYTFR
HLKPTEEYQNNIGEFFRDVAEDGYRIDFQGISDQYIHEKNEKGELHLFEIHNKDWNLDKARDGKSKTTQKNLHTLYFESL
FSNDNVVQNFPIKLNGQAEIFYRPKTEKDKLESKKDKKGNKVIDHKRYSENKIFFHVPLTLNRTKNDSYRFNAQINNFLA
NNKDINIIGVDRGEKHLVYYSVITQASDILESGSLNELNGVNYAEKLGKKAENREQARRDWQDVQGIKDLKKGYISQVVR
KLADLAIKHNAIIILEDLNMRFKQVRGGIEKSIYQQLEKALIDKLSFLVDKGEKNPEQAGHLLKAYQLSAPFETFQKMGK
QTGIIFYTQASYTSKSDPVTGWRPHLYLKYFSAKKAKDDIAKFTKIEFVNDRFELTYDIKDFQQAKEYPNKTVWKVCSNV
ERFRWDKNLNQNKGGYTHYTNITENIQELFTKYGIDITKDLLTQISTIDEKQNTSFFRDFIFYFNLICQIRNTDDSEIAK
KNGKDDFILSPVEPFFDSRKDNGNKLPENGDDNGAYNIARKGIVILNKISQYSEKNENCEKMKWGDLYVSNIDWDNFVTQ
ANARH
>Rb2Cas12a
MSVFKSFTNCYALSKTLRFELKPVGKTFENMRTQLAYNKDLQTFLKDQAIEDAYQKLKPLFDKLHEEFITDSLDSDQAKK
IDFSEYLVLYEAKKELQAIEKKLREEIGKTFIAAGEKWKQEKYAQYTWKKGSKVANGSDILLTQDVLELIRDLNDKNEEL
KKMIEETFKGFFTYLSGFNQNRKNYYTIKEEKATAVATRIVHENLPKFCDNILFFIDRQTEYLIAHSFLKEKGRDLVNKD
GKALLPITDSIFSIEHFNHCFSQKQIEAYNAQIGNANVLINLYNQAHNDEQGFKRLPAFKTLYKQIGCGKRKSLFFTLTC
DTEAEASKMRNENKEAFSVEEVLNLAYKAGEKYFQNSIENDSNLTIPKFCSYIEAQQDYDGIYWSKAALNTISNKYFANY
HVLKDRLKEVKVFQKAAKGSEEDVKIPEAIELEGLFAVIDEVDGWRDEDIFFKKSLIEERKDEKENKKNKKRLEVIKKAE
KPSQALINLIFFDINEHIEQFFDTSKAILSLQEYKSKESKEAIKAWMDHALAVNQILKYFLVKENKTKGNPLDSEISNAL
KNILFEGKIIFDGKEIDVDWFRWYDALRNYLTKKPQDDAKENKLKLNFKNSTLAGGWDINKEPDNHCVILQDQNDKQYLG
VIAKKEKQRGYNKIFEKTPENPLYKIDSGEVWQKMEYKQIAAPTGIGGFVRKCFKTAQQYGWKCPDNCLNSEGKIIIKND
EAKENLEAIIDCYKDFFIKYEKDGFSYKKFSFNFKKSSEYEELNNFFSDVERQGYKLDFTTINKAIIDQWVEDGTIYLFE
IKNQDANDGKKEGHKNNLHTIYWKALFENNEDKPKLNGGAELFYRKALPKSKQEKIKDNHGKEIIKNFRFSKEKFLFHCP
IKMNYKAKSYSDPKYALPEINNQINEALTTFGDIHFLGIDRGEKHLAYYSLVDKNGEMIDKGTLNLPFIDQEGKPRSIKK
PKYFYNKKKDKWESEEINCWDYNDLLDAMASNRDMARKNWQTIGTIKELKEGYISQVVRKIADIVVEHGAFIVLEDLNTG
FKRGRQKIEKSVYQKFELALAKKLNFLVDKSAKSGEIGSVTRALQLTPPVNNYGDIEKRKQVGIMLYTRANYTSQTDPET
GWRKIIYLKKGNEEAIKEQILQNFTDIWFDGLDYYFEYPNKNKSDKPWKLYSGKGGKSLDRFRRSRGKDKNEWTIEPVNV
VNILKQVFVNFDEKRSLRSQIIEGKALARTKEKTDFTAWEALRFAIDLIQQIRNTGNNEKDADFLHSPVRDTNGNHFDSR
SVSHDRPTSGDANGAYNIARKGLMMNEHIRTWAKKGKPKYDKNTNDLNLFISEEEWDLYLADKKAWQEKLLMFSSRKAMD
EEKKKHI
>Sm1Cas12a
MQTLFENFTNQYPVSKTLRFELIPQGKTKDFIEQKGLLKKDEDRAEKYKKVKNIIDEYHKDFIEKSLNGLKLDGLEEYKT
LYLKQEKDDKDKKAFDKEKENLRKQIANAFRNNEKFKTLFAKELIKNDLMSFACEEDKKNVKEFEAFTTYFTGFHQNRAN
MYVADEKRTAIASRLIHENLPKFIDNIKIFEKMKKEAPELLSPFNQTLKDMKDVIKGTTLEEIFSLDYFNKTLTQSGIDI
YNSVIGGRTPEEGKTKIKGLNEYINTDFNQKQTDKKKRQPKFKQLYKQILSDRQSLSFIAEAFKNDTEILEAIEKFYVNE
LLHFSNEGKSTNVLDAIKNAVSNLESFNLTKIYFRSGTSLTDVSRKVFGEWSIINRALDNYYATTYPIKPREKSEKYEER
KEKWLKQDFNVSLIQTAIDEYDNETVKGKNSGKVIVDYFAKFCDDKETDLIQKVNEGYIAVKDLLNTPYPENEKLGSNKD
QVKQIKAFMDSIMDIMHFVRPLSLKDTDKEKDETFYSLFTPLYDHLTQTIALYNKVRNYLTQKPYSTEKIKLNFENSTLL
GGWDLNKETDNTAIILRKENLYYLGIMDKRHNRIFRNVPKADKKDSCYEKMVYKLLPGANKMLPKVFFSQSRIQEFTPSA
KLLENYENETHKKGDNFNLNHCHQLIDFFKDSINKHEDWKNFDFRFSATSTYADLSGFYHEVEHQGYKISFQSIADSFID
DLVNEGKLYLFQIYNKDFSPFSKGKPNLHTLYWKMLFDENNLKDVVYKLNGEAEVFYRKKSIAEKNTTIHKANESIINKN
PDNPKATSTFNYDIVKDKRYTIDKFQFHVPITMNFKAEGIFNMNQRVNQFLKANPDINIIGIDRGERHLLYYTLINQKGK
ILKQDTLNVIANEKQKVDYHNLLDKKEGDRATARQEWGVIETIKELKEGYLSQVIHKLTDLMIENNAIIVMEDLNFGFKR
GRQKVEKQVYQKFEKMLIDKLNYLVDKNKKANELGGLLNAFQLANKFESFQKMGKQNGFIFYVPAWNTSKTDPATGFIDF
LKPRYENLKQAKDFFEKFDSIRLNSKADYFEFAFDFKNFTGKADGGRTKWTVCTTNEDRYAWNRALNNNRGSQEKYDITA
ELKSLFDGKVDYKSGKDLKQQIASQELADFFRTLMKYLSVTLSLRHNNGEKGETEQDYILSPVADSMGKFFDSRKAGDDM
PKNADANGAYHIALKGLWCLEQISKTDDLKKVKLAISNKEWLEFMQTLKG
>SuCas12a2
MLHAFTNQYQLSKTLRFGATLKEDEKKCKSHEELKGFVDISYENMKSSATIAESLNENELVKKCERCYSEIVKFHNAWEK
IYYRTDQIAVYKDFYRQLSRKARFDAGKQNSQLITLASLCGMYQGAKLSRYITNYWKDNITRQKSFLKDFSQQLHQYTRA
LEKSDKAHTKPNLINFNKTFMVLANLVNEIVIPLSNGAISFPNISKLEDGEESHLIEFALNDYSQLSELIGELKDAIATN
GGYTPFAKVTLNHYTAEQKPHVFKNDIDAKIRELKLIGLVETLKGKSSEQIEEYFSNLDKFSTYNDRNQSVIVRTQCFKY
KPIPFLVKHQLAKYISEPNGWDEDAVAKVLDAVGAIRSPAHDYANNQEGFDLNHYPIKVAFDYAWEQLANSLYTTVTFPQ
EMCEKYLNSIYGCEVSKEPVFKFYADLLYIRKNLAVLEHKNNLPSNQEEFICKINNTFENIVLPYKISQFETYKKDILAW
INDGHDHKKYTDAKQQLGFIRGGLKGRIKAEEVSQKDKYGKIKSYYENPYTKLTNEFKQISSTYGKTFAELRDKFKEKNE
ITKITHFGIIIEDKNRDRYLLASELKHEQINHVSTILNKLDKSSEFITYQVKSLTSKTLIKLIKNHTTKKGAISPYADFH
TSKTGFNKNEIEKNWDNYKREQVLVEYVKDCLTDSTMAKNQNWAEFGWNFEKCNSYEDIEHEIDQKSYLLQSDTISKQSI
ASLVEGGCLLLPIINQDITSKERKDKNQFSKDWNHIFEGSKEFRLHPEFAVSYRTPIEGYPVQKRYGRLQFVCAFNAHIV
PQNGEFINLKKQIENFNDEDVQKRNVTEFNKKVNHALSDKEYVVIGIDRGLKQLATLCVLDKRGKILGDFEIYKKEFVRA
EKRSESHWEHTQAETRHILDLSNLRVETTIEGKKVLVDQSLTLVKKNRDTPDEEATEENKQKIKLKQLSYIRKLQHKMQT
NEQDVLDLINNEPSDEEFKKRIEGLISSFGEGQKYADLPINTMREMISDLQGVIARGNNQTEKNKIIELDAADNLKQGIV
ANMIGIVNYIFAKYSYKAYISLEDLSRAYGGAKSGYDGRYLPSTSQDEDVDFKEQQNQMLAGLGTYQFFEMQLLKKLQKI
QSDNTVLRFVPAFRSADNYRNILRLEETKYKSKPFGVVHFIDPKFTSKKCPVCSKTNVYRDKDDILVCKECGFRSDSQLK
ERENNIHYIHNGDDNGAYHIALKSVENLIQMK
>TsCas12a
MTKTFDSEFFNLYSLQKTVRFELKPVGETASFVEDFKNEGLKRVVSEDERRAVDYQKVKEIIDDYHRDFIEESLNYFPEQ
VSKDALEQAFHLYQKLKAAKVEEREKALKEWEALQKKLREKVVKCFSDSNKARFSRIDKKELIKEDLINWLVAQNREDDI
PTVETFNNFTTYFTGFHENRKNIYSKDDHATAISFRLIHENLPKFFDNVISFNKLKEGFPELKFDKVKEDLEVDYDLKHA
FEIEYFVNFVTQAGIDQYNYLLGGKTLEDGTKKQGMNEQINLFKQQQTRDKARQIPKLIPLFKQILSERTESQSFIPKQF
ESDQELFDSLQKLHNNCQDKFTVLQQAILGLAEADLKKVFIKTSDLNALSNTIFGNYSVFSDALNLYKESLKTKKAQEAF
EKLPAHSIHDLIQYLEQFNSSLDAEKQQSTDTVLNYFIKTDELYSRFIKSTSEAFTQVQPLFELEALSSKRRPPESEDEG
AKGQEGFEQIKRIKAYLDTLMEAVHFAKPLYLVKGRKMIEGLDKDQSFYEAFEMAYQELESLIIPIYNKARSYLSRKPFK
ADKFKINFDNNTLLSGWDANKETANASILFKKDGLYYLGIMPKGKTFLFDYFVSSEDSEKLKQRRQKTAEEALAQDGESY
FEKIRYKLLPGASKMLPKVFFSNKNIGFYNPSDDILRIRNTASHTKNGTPQKGHSKVEFNLNDCHKMIDFFKSSIQKHPE
WGSFGFTFSDTSDFEDMSAFYREVENQGYVISFDKIKETYIQSQVEQGNLYLFQIYNKDFSPYSKGKPNLHTLYWKALFE
EANLNNVVAKLNGEAEIFFRRHSIKASDKVVHPANQAIDNKNPHTEKTQSTFEYDLVKDKRYTQDKFFFHVPISLNFKAQ
GVSKFNDKVNGFLKGNPDVNIIGIDRGERHLLYFTVVNQKGEILVQESLNTLMSDKGHVNDYQQKLDKKEQERDAARKSW
TTVENIKELKEGYLSHVVHKLAHLIIKYNAIVCLEDLNFGFKRGRFKVEKQVYQKFEKALIDKLNYLVFKEKELGEVGHY
LTAYQLTAPFESFKKLGKQSGILFYVPADYTSKIDPTTGFVNFLDLRYQSVEKAKQLLSDFNAIRFNSVQNYFEFEIDYK
KLTPKRKVGTQSKWVICTYGDVRYQNRRNQKGHWETEEVNVTEKLKALFASDSKTTTVIDYANDDNLIDVILEQDKASFF
KELLWLLKLTMTLRHSKIKSEDDFILSPVKNEQGEFYDSRKAGEVWPKDADANGAYHIALKGLWNLQQINQWEKGKTLNL
AIKNQDWFSFIQEKPYQE
>UbCas12a
MKDFYQFTNLYALSKTLRFSLIPTPATKQMLEDAKVFEKDETIQKKYEATKPYFDRLHREFALEALQDQKLDFKNYLELY
RKYKADKKASGKLLINIEKDLRKEVVKLFDKQGEKWAKQYPGLKNKNIGVLFKEAVFTVILKERYGNEKETQILDESSGQ
LVSIFDSWKGFIGYFKKFHETRKNFYKDDGTSTALATRIIDQNLKRFCDNILIFESTKEKVDFSEVEISFGKPLSEVFTL
EFYNTCFLQNGIDFYTKILGGETLQNGEKVKGLNECINLHKQKTGEKLPFFKSLDKQILSEKDKFFIDEISNETQLLEVL
KSFVASAESKTDTIKTLVDDFVKDQDKYDLNYIYFSNDGLNTITRKWTTETQVFEEALYTALKAAKVVSSSAKKNEGGYS
FPDFIPFAHLKTALESIKIDGTIWRDNFNAIENFEEKSIWAQFLAIYNFELSNLFETEIKNPEIGNCPTIGYNVYKQDFE
ELLKSFVYDPNAKVTIKNFADNVLSIYQMAKYFAVEKKRGWNTDYELDVFYTDPQNGYLQYYENAYEEIVQVYNKLRNYL
TKKPYSEEKWKLNFDSGTPIKYTTRAIIFNNTTNERYYLGLLKKGVAKPREFEPINNNIISSGEFRRMIIQQLKFQTLAG
KGYVRDFGVKYSEDKDGVKHLQQLIKKQYLSKYPCLKKIADGVYNDKKAFDADIKDVLLETYNLDFQPISEEFILNKNRL
GEIYLFEIHNKDWNLKDGKNKSGSKNLHTMYFESLFVDKTTFKLNNEGAEVFYRPATNEGKLGTKKDRNGKIIINHKRYA
TDKILFHCPIGLNKDAGKSYTFNAKINNMLANNPDINIIGVDRGEKHLAYYSVITQKGKILDRGSLNKVEGGDKQEIDYA
KKLEETAKNREQARKDWQAVEGIKDLKRGYISQVVRKLADLAIEHNAIIVFEDLNMRFKQIRGGIEKSVYQQLEKALIDK
LSFLVMKGEADPEKAGHLLKAYQLVAPFESFQSMGKQTGIIFYTQANYTSKIDPITGWRPNLYLKYTSAEKAKADILKFS
KIEFVNNRFELTYDIKNFVLDKKVVLSNKTKWTVCSSVERFRWNRRLESNQGNYEHYENLTENLSSLFKDFGFEIEQNII
RQVEQLATKGNEQFFRSFIFYVNLIFQIRNTDAKAKDQNKEDFILSPVEPFFDSRTPEKFGENLPENGDDNGAFNIARKG
IIMLNKISAYKQEVGNVDKIIWKDLFISAAEWDNFTQE