Exposure Outcome Effect type Point estimate (95%CI) P-value Estimator Heterogeneity P-value Precision No. variants VLDL-C CHD (OR) Total 1.29 (1.19; 1.41) < 0.001 IVW 0.120 5.2×10² 11 VLDL-C CHD (OR) LDL-C independent 1.25 (1.14; 1.37) < 0.001 IVW < 0.001 4.6×10² 33 VLDL-C CHD (OR) HDL-C independent 1.21 (1.10; 1.32) < 0.001 IVW 0.138 4.7×10² 29 VLDL-C CHD (OR) TG independent 1.16 (0.93; 1.46) 0.191 IVW < 0.001 7.6×10¹ 21 VLDL-C CHD (OR) LDL-C & HDL-C & TG independent 1.21 (1.04; 1.40) 0.014 IVW < 0.001 1.7×10² 58 VLDL-C HF (OR) Total 1.10 (1.06; 1.15) < 0.001 IVW < 0.001 2.3×10³ 27 VLDL-C HF (OR) LDL-C independent 1.08 (1.04; 1.13) < 0.001 IVW < 0.001 1.9×10³ 103 VLDL-C HF (OR) HDL-C independent 1.10 (1.06; 1.15) < 0.001 IVW < 0.001 2.1×10³ 89 VLDL-C HF (OR) TG independent 1.11 (0.95; 1.29) 0.186 IVW 0.006 1.7×10² 67 VLDL-C HF (OR) LDL-C & HDL-C & TG independent 1.10 (1.02; 1.19) 0.012 IVW < 0.001 6.7×10² 188 VLDL-C AF (OR) Total 1.03 (0.99; 1.06) 0.186 IVW 0.198 2.7×10³ 28 VLDL-C AF (OR) LDL-C independent 1.04 (1.00; 1.08) 0.064 IVW 0.017 2.6×10³ 107 VLDL-C AF (OR) HDL-C independent 1.01 (0.97; 1.05) 0.628 IVW 0.443 3.0×10³ 93 VLDL-C AF (OR) TG independent 1.08 (0.95; 1.22) 0.239 IVW 0.030 2.4×10² 69 VLDL-C AF (OR) LDL-C & HDL-C & TG independent 1.06 (0.99; 1.13) 0.083 IVW 0.002 9.2×10² 195 VLDL-C Any stroke (OR) Total 1.02 (0.97; 1.07) 0.403 IVW 0.501 1.8×10³ 27 VLDL-C Any stroke (OR) LDL-C independent 1.02 (0.97; 1.08) 0.400 IVW 0.002 1.4×10³ 103 VLDL-C Any stroke (OR) HDL-C independent 1.03 (0.96; 1.11) 0.366 MR Egger 0.008 7.9×10² 92 VLDL-C Any stroke (OR) TG independent 0.90 (0.75; 1.08) 0.258 IVW 0.335 1.1×10² 70 VLDL-C Any stroke (OR) LDL-C & HDL-C & TG independent 1.02 (0.93; 1.12) 0.612 IVW < 0.001 4.5×10² 193 VLDL-C Any ischemic stroke (OR) Total 0.90 (0.74; 1.10) 0.309 MR Egger 0.756 9.4×10¹ 26 VLDL-C Any ischemic stroke (OR) LDL-C independent 1.01 (0.95; 1.07) 0.769 IVW 0.010 1.2×10³ 102 VLDL-C Any ischemic stroke (OR) HDL-C independent 0.99 (0.94; 1.05) 0.807 IVW 0.013 1.3×10³ 91 VLDL-C Any ischemic stroke (OR) TG independent 0.89 (0.73; 1.08) 0.229 IVW 0.503 1.0×10² 70 VLDL-C Any ischemic stroke (OR) LDL-C & HDL-C & TG independent 1.00 (0.91; 1.11) 0.926 IVW 0.006 3.8×10² 192 VLDL-C Large artery stroke (OR) Total 1.10 (0.97; 1.25) 0.140 IVW 0.339 2.3×10² 28 VLDL-C Large artery stroke (OR) LDL-C independent 0.97 (0.85; 1.12) 0.726 IVW < 0.001 1.9×10² 105 VLDL-C Large artery stroke (OR) HDL-C independent 1.02 (0.89; 1.17) 0.766 IVW 0.006 2.2×10² 92 VLDL-C Large artery stroke (OR) TG independent 1.28 (0.78; 2.09) 0.324 IVW 0.320 1.6×10¹ 72 VLDL-C Large artery stroke (OR) LDL-C & HDL-C & TG independent 0.74 (0.57; 0.94) 0.015 IVW 0.006 6.3×10¹ 194 VLDL-C Cardioembolic stroke (OR) Total 0.98 (0.89; 1.08) 0.698 IVW 0.621 4.1×10² 28 VLDL-C Cardioembolic stroke (OR) LDL-C independent 1.02 (0.91; 1.14) 0.724 IVW 0.028 3.1×10² 104 VLDL-C Cardioembolic stroke (OR) HDL-C independent 1.01 (0.91; 1.12) 0.845 IVW 0.732 3.6×10² 92 VLDL-C Cardioembolic stroke (OR) TG independent 0.82 (0.57; 1.19) 0.297 IVW 0.714 2.9×10¹ 72 VLDL-C Cardioembolic stroke (OR) LDL-C & HDL-C & TG independent 1.00 (0.82; 1.21) 0.981 IVW 0.009 1.0×10² 195 VLDL-C Small vessel stroke (OR) Total 1.11 (0.99; 1.25) 0.068 IVW 0.737 3.0×10² 28 VLDL-C Small vessel stroke (OR) LDL-C independent 1.16 (1.01; 1.34) 0.035 IVW 0.156 2.0×10² 106 VLDL-C Small vessel stroke (OR) HDL-C independent 1.17 (0.98; 1.39) 0.086 MR Egger 0.270 1.3×10² 94 VLDL-C Small vessel stroke (OR) TG independent 0.73 (0.50; 1.07) 0.109 MR Egger 0.009 2.7×10¹ 73 VLDL-C Small vessel stroke (OR) LDL-C & HDL-C & TG independent 1.03 (0.82; 1.29) 0.803 IVW 0.002 7.5×10¹ 196 VLDL-C cIMT (mm) Total 0.00 (-0.00; 0.01) 0.111 IVW 0.005 3.0×10⁵ 26 VLDL-C cIMT (mm) LDL-C independent -0.00 (-0.01; 0.00) 0.183 IVW < 0.001 2.4×10⁵ 105 VLDL-C cIMT (mm) HDL-C independent -0.01 (-0.01; -0.00) 0.025 MR Egger < 0.001 1.4×10⁵ 92 VLDL-C cIMT (mm) TG independent 0.01 (-0.01; 0.02) 0.310 IVW < 0.001 2.5×10⁴ 72 VLDL-C cIMT (mm) LDL-C & HDL-C & TG independent 0.00 (-0.01; 0.01) 0.891 IVW < 0.001 7.8×10⁴ 194 VLDL-C Carotid plaque (OR) Total 1.13 (1.04; 1.23) 0.003 IVW 0.014 5.6×10² 26 VLDL-C Carotid plaque (OR) LDL-C independent 1.11 (0.99; 1.23) 0.069 IVW 0.083 3.2×10² 103 VLDL-C Carotid plaque (OR) HDL-C independent 1.14 (1.04; 1.26) 0.008 IVW 0.094 4.0×10² 89 VLDL-C Carotid plaque (OR) TG independent 1.35 (0.99; 1.85) 0.062 IVW 0.031 3.9×10¹ 70 VLDL-C Carotid plaque (OR) LDL-C & HDL-C & TG independent 1.32 (1.12; 1.56) < 0.001 IVW 0.019 1.4×10² 192 VLDL-C Glucose (mmol/l) Total -0.01 (-0.08; 0.05) 0.652 MR Egger < 0.001 9.3×10² 23 VLDL-C Glucose (mmol/l) LDL-C independent 0.01 (-0.01; 0.03) 0.192 IVW 0.002 1.2×10⁴ 98 VLDL-C Glucose (mmol/l) HDL-C independent 0.01 (-0.01; 0.02) 0.460 IVW < 0.001 1.4×10⁴ 83 VLDL-C Glucose (mmol/l) TG independent 0.11 (0.06; 0.17) < 0.001 IVW < 0.001 1.2×10³ 66 VLDL-C Glucose (mmol/l) LDL-C & HDL-C & TG independent 0.02 (-0.01; 0.06) 0.144 MR Egger < 0.001 3.7×10³ 180 VLDL-C HbA1c (mmol/mol) Total -0.07 (-0.15; 0.01) 0.103 IVW < 0.001 5.7×10² 22 VLDL-C HbA1c (mmol/mol) LDL-C independent -0.10 (-0.19; -0.01) 0.036 IVW < 0.001 4.6×10² 97 VLDL-C HbA1c (mmol/mol) HDL-C independent -0.18 (-0.29; -0.06) 0.002 MR Egger < 0.001 2.9×10² 82 VLDL-C HbA1c (mmol/mol) TG independent 0.28 (-0.02; 0.58) 0.069 IVW < 0.001 4.2×10¹ 59 VLDL-C HbA1c (mmol/mol) LDL-C & HDL-C & TG independent -0.02 (-0.18; 0.13) 0.746 IVW < 0.001 1.7×10² 178 VLDL-C T2DM (OR) Total 1.04 (1.01; 1.08) 0.024 IVW < 0.001 2.8×10³ 19 VLDL-C T2DM (OR) LDL-C independent 1.05 (1.01; 1.09) 0.008 IVW < 0.001 2.6×10³ 87 VLDL-C T2DM (OR) HDL-C independent 1.04 (1.00; 1.08) 0.043 IVW < 0.001 2.9×10³ 79 VLDL-C T2DM (OR) TG independent 1.31 (1.16; 1.49) < 0.001 IVW < 0.001 2.4×10² 58 VLDL-C T2DM (OR) LDL-C & HDL-C & TG independent 1.11 (1.04; 1.20) 0.003 MR Egger < 0.001 7.5×10² 170 VLDL-C CRP (mg/L) Total 0.07 (0.01; 0.13) 0.014 IVW 0.014 1.1×10³ 21 VLDL-C CRP (mg/L) LDL-C independent 0.16 (0.10; 0.22) < 0.001 IVW < 0.001 9.6×10² 87 VLDL-C CRP (mg/L) HDL-C independent 0.04 (-0.04; 0.11) 0.369 MR Egger 0.014 6.3×10² 85 VLDL-C CRP (mg/L) TG independent 0.09 (-0.14; 0.31) 0.458 IVW < 0.001 7.5×10¹ 58 VLDL-C CRP (mg/L) LDL-C & HDL-C & TG independent 0.16 (0.05; 0.27) 0.003 IVW < 0.001 3.4×10² 168 VLDL-C SBP (mmHg) Total 0.86 (0.71; 1.02) < 0.001 IVW < 0.001 1.6×10² 24 VLDL-C SBP (mmHg) LDL-C independent 0.45 (0.27; 0.63) < 0.001 IVW < 0.001 1.2×10² 91 VLDL-C SBP (mmHg) HDL-C independent 0.53 (0.36; 0.69) < 0.001 IVW < 0.001 1.3×10² 81 VLDL-C SBP (mmHg) TG independent 0.23 (-0.42; 0.88) 0.488 IVW 0.004 9.1 60 VLDL-C SBP (mmHg) LDL-C & HDL-C & TG independent 0.39 (0.09; 0.69) 0.011 IVW < 0.001 4.2×10¹ 172 VLDL-C DBP (mmHg) Total 0.25 (0.16; 0.34) < 0.001 IVW < 0.001 4.6×10² 23 VLDL-C DBP (mmHg) LDL-C independent 0.20 (0.10; 0.30) < 0.001 IVW < 0.001 3.6×10² 89 VLDL-C DBP (mmHg) HDL-C independent 0.12 (0.03; 0.22) 0.013 IVW 0.034 4.2×10² 80 VLDL-C DBP (mmHg) TG independent -0.04 (-0.41; 0.33) 0.825 IVW < 0.001 2.8×10¹ 58 VLDL-C DBP (mmHg) LDL-C & HDL-C & TG independent -0.18 (-0.36; -0.00) 0.044 IVW < 0.001 1.2×10² 166 VLDL-C PBL (OR) Total 1.76 (0.41; 7.55) 0.446 MR Egger 0.103 1.8 17 VLDL-C PBL (OR) LDL-C independent 0.97 (0.77; 1.23) 0.825 IVW 0.023 7.2×10¹ 62 VLDL-C PBL (OR) HDL-C independent 1.14 (0.89; 1.46) 0.294 IVW 0.170 6.3×10¹ 53 VLDL-C PBL (OR) TG independent 0.81 (0.41; 1.62) 0.559 IVW 0.003 8.0 41 VLDL-C PBL (OR) LDL-C & HDL-C & TG independent 0.73 (0.51; 1.04) 0.084 IVW < 0.001 3.1×10¹ 115 VLDL-C BUN (mg/dl) Total -0.00 (-0.01; 0.00) 0.301 IVW < 0.001 1.7×10⁵ 23 VLDL-C BUN (mg/dl) LDL-C independent -0.00 (-0.01; 0.00) 0.212 IVW < 0.001 1.3×10⁵ 98 VLDL-C BUN (mg/dl) HDL-C independent -0.00 (-0.01; 0.00) 0.664 IVW 0.002 1.6×10⁵ 87 VLDL-C BUN (mg/dl) TG independent -0.00 (-0.02; 0.01) 0.647 IVW 0.023 1.3×10⁴ 68 VLDL-C BUN (mg/dl) LDL-C & HDL-C & TG independent -0.01 (-0.01; 0.00) 0.223 IVW < 0.001 4.9×10⁴ 186 VLDL-C eGFR (SD of log(eGFR)) Total 0.01 (-0.00; 0.01) 0.068 MR Egger < 0.001 7.6×10⁴ 24 VLDL-C eGFR (SD of log(eGFR)) LDL-C independent 0.00 (0.00; 0.01) 0.004 MR Egger < 0.001 5.6×10⁵ 98 VLDL-C eGFR (SD of log(eGFR)) HDL-C independent 0.00 (0.00; 0.01) 0.012 MR Egger 0.005 5.5×10⁵ 85 VLDL-C eGFR (SD of log(eGFR)) TG independent 0.01 (-0.00; 0.01) 0.155 IVW < 0.001 6.5×10⁴ 63 VLDL-C eGFR (SD of log(eGFR)) LDL-C & HDL-C & TG independent 0.00 (0.00; 0.01) 0.021 IVW < 0.001 3.0×10⁵ 179 VLDL-C CKD (OR) Total 1.03 (0.98; 1.07) 0.296 IVW 0.028 1.7×10³ 26 VLDL-C CKD (OR) LDL-C independent 1.03 (0.97; 1.09) 0.299 IVW 0.004 1.3×10³ 103 VLDL-C CKD (OR) HDL-C independent 1.02 (0.96; 1.08) 0.567 IVW 0.051 1.2×10³ 87 VLDL-C CKD (OR) TG independent 0.98 (0.82; 1.17) 0.803 IVW 0.002 1.2×10² 70 VLDL-C CKD (OR) LDL-C & HDL-C & TG independent 1.01 (0.92; 1.11) 0.797 IVW < 0.001 4.5×10² 191 VLDL-C IBD (OR) Total 0.86 (0.63; 1.18) 0.358 MR Egger 0.031 3.8×10¹ 26 VLDL-C IBD (OR) LDL-C independent 1.00 (0.90; 1.10) 0.977 IVW 0.006 3.8×10² 102 VLDL-C IBD (OR) HDL-C independent 0.99 (0.91; 1.08) 0.859 IVW 0.009 4.8×10² 90 VLDL-C IBD (OR) TG independent 0.95 (0.70; 1.29) 0.722 IVW < 0.001 4.1×10¹ 71 VLDL-C IBD (OR) LDL-C & HDL-C & TG independent 0.89 (0.76; 1.06) 0.193 IVW < 0.001 1.4×10² 193 VLDL-C UC (OR) Total 0.77 (0.52; 1.15) 0.201 MR Egger 0.032 2.4×10¹ 27 VLDL-C UC (OR) LDL-C independent 0.92 (0.81; 1.05) 0.209 IVW 0.008 2.4×10² 104 VLDL-C UC (OR) HDL-C independent 0.98 (0.84; 1.15) 0.831 MR Egger 0.010 1.6×10² 92 VLDL-C UC (OR) TG independent 0.90 (0.62; 1.32) 0.600 IVW 0.021 2.6×10¹ 72 VLDL-C UC (OR) LDL-C & HDL-C & TG independent 0.86 (0.70; 1.06) 0.161 IVW < 0.001 8.7×10¹ 195 VLDL-C CD (OR) Total 1.02 (0.66; 1.56) 0.938 MR Egger 0.048 2.1×10¹ 26 VLDL-C CD (OR) LDL-C independent 1.11 (0.96; 1.27) 0.158 IVW 0.376 2.0×10² 102 VLDL-C CD (OR) HDL-C independent 1.09 (0.95; 1.24) 0.235 IVW 0.077 2.1×10² 90 VLDL-C CD (OR) TG independent 0.72 (0.48; 1.09) 0.122 IVW 0.039 2.2×10¹ 72 VLDL-C CD (OR) LDL-C & HDL-C & TG independent 1.00 (0.78; 1.28) 0.978 IVW 0.054 6.3×10¹ 194 VLDL-C Arthritis (OR) Total 0.97 (0.87; 1.09) 0.604 IVW 0.155 3.1×10² 26 VLDL-C Arthritis (OR) LDL-C independent 0.99 (0.88; 1.10) 0.814 IVW < 0.001 3.0×10² 95 VLDL-C Arthritis (OR) HDL-C independent 1.02 (0.86; 1.22) 0.781 MR Egger 0.148 1.3×10² 79 VLDL-C Arthritis (OR) TG independent 1.30 (0.84; 1.99) 0.235 IVW 0.234 2.1×10¹ 62 VLDL-C Arthritis (OR) LDL-C & HDL-C & TG independent 1.11 (0.89; 1.38) 0.344 IVW 0.022 8.3×10¹ 166 VLDL-C ALS (OR) Total 1.07 (0.98; 1.17) 0.131 IVW 0.510 5.1×10² 28 VLDL-C ALS (OR) LDL-C independent 1.00 (0.90; 1.10) 0.970 IVW 0.491 3.9×10² 106 VLDL-C ALS (OR) HDL-C independent 1.00 (0.91; 1.09) 0.924 IVW 0.259 4.3×10² 92 VLDL-C ALS (OR) TG independent 0.81 (0.58; 1.15) 0.237 IVW 0.242 3.3×10¹ 69 VLDL-C ALS (OR) LDL-C & HDL-C & TG independent 0.78 (0.66; 0.93) 0.004 IVW 0.428 1.4×10² 191 VLDL-C MS (OR) Total 0.92 (0.81; 1.03) 0.154 IVW 0.758 2.7×10² 11 VLDL-C MS (OR) LDL-C independent 0.87 (0.73; 1.04) 0.129 IVW 0.155 1.2×10² 27 VLDL-C MS (OR) HDL-C independent 0.89 (0.74; 1.06) 0.198 IVW 0.187 1.2×10² 19 VLDL-C MS (OR) TG independent 1.23 (0.60; 2.53) 0.576 IVW 0.902 7.4 17 VLDL-C MS (OR) LDL-C & HDL-C & TG independent 0.98 (0.65; 1.46) 0.910 IVW 0.007 2.4×10¹ 38 VLDL-C Alzheimer (OR) Total 1.02 (1.00; 1.03) 0.014 IVW 0.839 2.1×10⁴ 22 VLDL-C Alzheimer (OR) LDL-C independent 1.00 (0.98; 1.02) 0.792 MR Egger < 0.001 9.9×10³ 67 VLDL-C Alzheimer (OR) HDL-C independent 1.01 (1.00; 1.03) 0.087 IVW 0.094 1.6×10⁴ 86 VLDL-C Alzheimer (OR) TG independent 1.02 (0.97; 1.08) 0.387 IVW 0.072 1.5×10³ 63 VLDL-C Alzheimer (OR) LDL-C & HDL-C & TG independent 0.96 (0.94; 0.99) 0.007 IVW < 0.001 5.3×10³ 150 VLDL-C Parkinson (OR) Total 1.17 (0.80; 1.71) 0.424 MR Egger 0.781 2.6×10¹ 24 VLDL-C Parkinson (OR) LDL-C independent 1.05 (0.89; 1.23) 0.570 MR Egger 0.070 1.5×10² 102 VLDL-C Parkinson (OR) HDL-C independent 1.02 (0.93; 1.13) 0.631 IVW 0.434 3.9×10² 89 VLDL-C Parkinson (OR) TG independent 1.39 (0.99; 1.95) 0.059 IVW 0.021 3.3×10¹ 71 VLDL-C Parkinson (OR) LDL-C & HDL-C & TG independent 1.22 (1.02; 1.46) 0.029 IVW 0.005 1.2×10² 192 VLDL-C Pancreatic cancer (OR) Total 0.76 (0.57; 1.00) 0.047 IVW 0.951 5.0×10¹ 27 VLDL-C Pancreatic cancer (OR) LDL-C independent 0.73 (0.53; 1.00) 0.052 IVW 0.003 3.7×10¹ 104 VLDL-C Pancreatic cancer (OR) HDL-C independent 0.76 (0.55; 1.06) 0.103 IVW 0.248 3.7×10¹ 87 VLDL-C Pancreatic cancer (OR) TG independent 1.30 (0.41; 4.10) 0.650 IVW 0.234 2.9 70 VLDL-C Pancreatic cancer (OR) LDL-C & HDL-C & TG independent 0.33 (0.18; 0.62) < 0.001 MR Egger < 0.001 1.0×10¹ 192 VLDL-C Colon cancer (OR) Total 1.64 (1.02; 2.64) 0.041 MR Egger 0.823 1.7×10¹ 25 VLDL-C Colon cancer (OR) LDL-C independent 0.94 (0.82; 1.07) 0.350 IVW 0.020 2.1×10² 101 VLDL-C Colon cancer (OR) HDL-C independent 1.13 (0.94; 1.37) 0.192 MR Egger 0.261 1.1×10² 90 VLDL-C Colon cancer (OR) TG independent 1.77 (1.14; 2.75) 0.011 IVW 0.017 2.0×10¹ 70 VLDL-C Colon cancer (OR) LDL-C & HDL-C & TG independent 1.13 (0.90; 1.43) 0.303 IVW 0.011 7.0×10¹ 188 VLDL-C Rectal cancer (OR) Total 1.34 (1.15; 1.56) < 0.001 IVW 0.485 1.6×10² 27 VLDL-C Rectal cancer (OR) LDL-C independent 1.20 (1.00; 1.43) 0.049 IVW 0.870 1.2×10² 102 VLDL-C Rectal cancer (OR) HDL-C independent 1.48 (1.15; 1.91) 0.002 MR Egger 0.265 6.0×10¹ 89 VLDL-C Rectal cancer (OR) TG independent 1.74 (0.95; 3.16) 0.071 IVW 0.463 1.1×10¹ 70 VLDL-C Rectal cancer (OR) LDL-C & HDL-C & TG independent 1.16 (0.84; 1.58) 0.372 IVW 0.358 3.8×10¹ 188 VLDL-C Melanoma (OR) Total 0.99 (0.68; 1.43) 0.937 MR Egger 0.339 2.8×10¹ 26 VLDL-C Melanoma (OR) LDL-C independent 1.00 (0.90; 1.10) 0.945 IVW 0.038 3.7×10² 103 VLDL-C Melanoma (OR) HDL-C independent 1.05 (0.95; 1.16) 0.314 IVW < 0.001 4.1×10² 88 VLDL-C Melanoma (OR) TG independent 1.10 (0.79; 1.55) 0.573 IVW 0.002 3.4×10¹ 70 VLDL-C Melanoma (OR) LDL-C & HDL-C & TG independent 1.00 (0.84; 1.19) 0.971 IVW < 0.001 1.2×10² 191 VLDL-C Lung cancer (OR) Total 0.89 (0.77; 1.02) 0.104 IVW 0.505 2.0×10² 27 VLDL-C Lung cancer (OR) LDL-C independent 0.90 (0.76; 1.08) 0.251 IVW 0.262 1.2×10² 102 VLDL-C Lung cancer (OR) HDL-C independent 0.96 (0.82; 1.13) 0.642 IVW 0.016 1.5×10² 88 VLDL-C Lung cancer (OR) TG independent 0.98 (0.60; 1.59) 0.938 IVW 0.906 1.6×10¹ 71 VLDL-C Lung cancer (OR) LDL-C & HDL-C & TG independent 0.98 (0.73; 1.32) 0.889 IVW 0.233 4.3×10¹ 191