Exposure Outcome Effect type Point estimate (95%CI) P-value Estimator Heterogeneity P-value Precision No. variants IDL-C CHD (OR) Total 1.52 (1.44; 1.61) < 0.001 IVW < 0.001 1.2×10³ 29 IDL-C CHD (OR) LDL-C independent 1.71 (1.09; 2.70) 0.020 IVW < 0.001 1.9×10¹ 32 IDL-C CHD (OR) HDL-C independent 1.57 (1.49; 1.66) < 0.001 IVW < 0.001 1.4×10³ 51 IDL-C CHD (OR) TG independent 1.27 (1.18; 1.37) < 0.001 MR Egger < 0.001 6.4×10² 48 IDL-C CHD (OR) LDL-C & HDL-C & TG independent 1.42 (0.98; 2.05) 0.062 IVW < 0.001 2.9×10¹ 62 IDL-C HF (OR) Total 1.03 (1.00; 1.06) 0.077 IVW < 0.001 4.3×10³ 107 IDL-C HF (OR) LDL-C independent 1.22 (0.97; 1.54) 0.095 MR Egger < 0.001 7.2×10¹ 130 IDL-C HF (OR) HDL-C independent 1.04 (1.01; 1.07) 0.011 IVW < 0.001 4.7×10³ 179 IDL-C HF (OR) TG independent 0.97 (0.92; 1.01) 0.168 MR Egger < 0.001 1.7×10³ 158 IDL-C HF (OR) LDL-C & HDL-C & TG independent 1.09 (0.93; 1.28) 0.267 IVW < 0.001 1.6×10² 236 IDL-C AF (OR) Total 1.01 (0.98; 1.04) 0.495 IVW 0.100 4.6×10³ 115 IDL-C AF (OR) LDL-C independent 1.20 (0.98; 1.47) 0.082 MR Egger 0.016 9.4×10¹ 142 IDL-C AF (OR) HDL-C independent 1.02 (1.00; 1.05) 0.107 IVW 0.135 5.5×10³ 191 IDL-C AF (OR) TG independent 1.01 (0.98; 1.04) 0.415 IVW < 0.001 4.7×10³ 176 IDL-C AF (OR) LDL-C & HDL-C & TG independent 1.16 (1.02; 1.32) 0.021 IVW < 0.001 2.3×10² 256 IDL-C Any stroke (OR) Total 1.06 (1.02; 1.10) < 0.001 IVW < 0.001 3.1×10³ 111 IDL-C Any stroke (OR) LDL-C independent 0.96 (0.73; 1.25) 0.764 IVW < 0.001 5.4×10¹ 132 IDL-C Any stroke (OR) HDL-C independent 1.05 (1.01; 1.09) 0.006 IVW < 0.001 3.2×10³ 185 IDL-C Any stroke (OR) TG independent 1.00 (0.95; 1.06) 0.897 MR Egger < 0.001 1.4×10³ 168 IDL-C Any stroke (OR) LDL-C & HDL-C & TG independent 1.04 (0.86; 1.26) 0.685 IVW < 0.001 1.1×10² 242 IDL-C Any ischemic stroke (OR) Total 1.06 (1.02; 1.10) 0.003 IVW < 0.001 2.7×10³ 112 IDL-C Any ischemic stroke (OR) LDL-C independent 1.09 (0.82; 1.46) 0.544 IVW < 0.001 4.6×10¹ 133 IDL-C Any ischemic stroke (OR) HDL-C independent 1.04 (1.00; 1.08) 0.033 IVW < 0.001 2.8×10³ 187 IDL-C Any ischemic stroke (OR) TG independent 1.00 (0.95; 1.06) 0.866 MR Egger < 0.001 1.2×10³ 168 IDL-C Any ischemic stroke (OR) LDL-C & HDL-C & TG independent 1.00 (0.82; 1.23) 0.985 IVW < 0.001 9.3×10¹ 243 IDL-C Large artery stroke (OR) Total 1.05 (0.95; 1.16) 0.346 IVW < 0.001 4.0×10² 108 IDL-C Large artery stroke (OR) LDL-C independent 0.36 (0.17; 0.74) 0.006 IVW < 0.001 7.2 133 IDL-C Large artery stroke (OR) HDL-C independent 1.04 (0.94; 1.14) 0.437 IVW < 0.001 4.2×10² 185 IDL-C Large artery stroke (OR) TG independent 1.08 (0.97; 1.21) 0.182 IVW < 0.001 3.1×10² 166 IDL-C Large artery stroke (OR) LDL-C & HDL-C & TG independent 0.70 (0.42; 1.17) 0.177 IVW < 0.001 1.5×10¹ 244 IDL-C Cardioembolic stroke (OR) Total 0.96 (0.89; 1.04) 0.332 IVW 0.033 6.8×10² 111 IDL-C Cardioembolic stroke (OR) LDL-C independent 1.24 (0.71; 2.17) 0.458 IVW 0.006 1.2×10¹ 135 IDL-C Cardioembolic stroke (OR) HDL-C independent 0.95 (0.89; 1.02) 0.189 IVW 0.006 7.2×10² 187 IDL-C Cardioembolic stroke (OR) TG independent 0.99 (0.90; 1.08) 0.753 IVW 0.092 4.6×10² 168 IDL-C Cardioembolic stroke (OR) LDL-C & HDL-C & TG independent 1.43 (0.95; 2.13) 0.083 IVW 0.004 2.4×10¹ 244 IDL-C Small vessel stroke (OR) Total 1.00 (0.91; 1.10) 0.956 IVW 0.291 4.6×10² 112 IDL-C Small vessel stroke (OR) LDL-C independent 0.83 (0.40; 1.71) 0.608 IVW 0.054 7.3 137 IDL-C Small vessel stroke (OR) HDL-C independent 0.96 (0.84; 1.09) 0.543 MR Egger 0.099 2.2×10² 186 IDL-C Small vessel stroke (OR) TG independent 0.83 (0.72; 0.95) 0.008 MR Egger 0.024 2.0×10² 167 IDL-C Small vessel stroke (OR) LDL-C & HDL-C & TG independent 1.10 (0.68; 1.76) 0.702 IVW 0.002 1.7×10¹ 245 IDL-C cIMT (mm) Total 0.01 (0.01; 0.02) < 0.001 MR Egger < 0.001 1.4×10⁵ 117 IDL-C cIMT (mm) LDL-C independent 0.00 (-0.02; 0.02) 0.969 IVW < 0.001 9.3×10³ 137 IDL-C cIMT (mm) HDL-C independent 0.02 (0.01; 0.02) < 0.001 IVW < 0.001 5.4×10⁵ 186 IDL-C cIMT (mm) TG independent 0.02 (0.01; 0.02) < 0.001 MR Egger < 0.001 2.1×10⁵ 169 IDL-C cIMT (mm) LDL-C & HDL-C & TG independent 0.02 (0.01; 0.03) 0.006 IVW < 0.001 1.8×10⁴ 247 IDL-C Carotid plaque (OR) Total 1.38 (1.29; 1.48) < 0.001 IVW 0.008 8.4×10² 105 IDL-C Carotid plaque (OR) LDL-C independent 0.59 (0.35; 1.01) 0.052 MR Egger 0.023 1.4×10¹ 129 IDL-C Carotid plaque (OR) HDL-C independent 1.41 (1.32; 1.51) < 0.001 IVW 0.011 8.5×10² 178 IDL-C Carotid plaque (OR) TG independent 1.32 (1.18; 1.48) < 0.001 MR Egger 0.002 3.1×10² 156 IDL-C Carotid plaque (OR) LDL-C & HDL-C & TG independent 1.22 (0.86; 1.73) 0.275 MR Egger 0.013 3.1×10¹ 239 IDL-C Glucose (mmol/l) Total -0.01 (-0.02; 0.00) 0.194 IVW 0.010 3.7×10⁴ 110 IDL-C Glucose (mmol/l) LDL-C independent 0.09 (0.01; 0.17) 0.033 IVW 0.039 5.8×10² 135 IDL-C Glucose (mmol/l) HDL-C independent -0.01 (-0.02; 0.00) 0.115 IVW < 0.001 3.6×10⁴ 179 IDL-C Glucose (mmol/l) TG independent -0.01 (-0.02; 0.01) 0.487 MR Egger < 0.001 1.5×10⁴ 164 IDL-C Glucose (mmol/l) LDL-C & HDL-C & TG independent 0.07 (0.01; 0.12) 0.020 IVW < 0.001 1.3×10³ 241 IDL-C HbA1c (mmol/mol) Total -0.10 (-0.21; 0.01) 0.083 MR Egger < 0.001 3.2×10² 106 IDL-C HbA1c (mmol/mol) LDL-C independent 0.71 (0.30; 1.12) < 0.001 MR Egger < 0.001 2.3×10¹ 132 IDL-C HbA1c (mmol/mol) HDL-C independent -0.12 (-0.17; -0.06) < 0.001 IVW < 0.001 1.4×10³ 174 IDL-C HbA1c (mmol/mol) TG independent -0.02 (-0.08; 0.04) 0.535 IVW < 0.001 1.0×10³ 161 IDL-C HbA1c (mmol/mol) LDL-C & HDL-C & TG independent 0.18 (-0.10; 0.46) 0.215 IVW < 0.001 4.9×10¹ 237 IDL-C T2DM (OR) Total 0.93 (0.91; 0.96) < 0.001 IVW < 0.001 6.4×10³ 96 IDL-C T2DM (OR) LDL-C independent 1.23 (1.01; 1.49) 0.039 MR Egger < 0.001 1.0×10² 122 IDL-C T2DM (OR) HDL-C independent 0.93 (0.91; 0.95) < 0.001 IVW < 0.001 6.7×10³ 159 IDL-C T2DM (OR) TG independent 0.93 (0.91; 0.96) < 0.001 IVW < 0.001 5.0×10³ 142 IDL-C T2DM (OR) LDL-C & HDL-C & TG independent 0.85 (0.74; 0.97) 0.016 MR Egger < 0.001 2.1×10² 215 IDL-C CRP (mg/L) Total -0.20 (-0.28; -0.12) < 0.001 MR Egger < 0.001 5.7×10² 100 IDL-C CRP (mg/L) LDL-C independent 0.67 (0.31; 1.03) < 0.001 MR Egger < 0.001 2.9×10¹ 114 IDL-C CRP (mg/L) HDL-C independent -0.06 (-0.10; -0.02) 0.002 IVW < 0.001 2.4×10³ 164 IDL-C CRP (mg/L) TG independent -0.10 (-0.16; -0.04) 0.002 MR Egger < 0.001 1.0×10³ 149 IDL-C CRP (mg/L) LDL-C & HDL-C & TG independent 0.29 (0.08; 0.50) 0.007 IVW < 0.001 8.7×10¹ 226 IDL-C SBP (mmHg) Total 0.47 (0.35; 0.60) < 0.001 IVW < 0.001 2.5×10² 85 IDL-C SBP (mmHg) LDL-C independent -0.20 (-1.25; 0.86) 0.717 MR Egger < 0.001 3.4 99 IDL-C SBP (mmHg) HDL-C independent 0.49 (0.37; 0.61) < 0.001 IVW < 0.001 2.6×10² 145 IDL-C SBP (mmHg) TG independent 0.24 (0.10; 0.39) < 0.001 IVW < 0.001 1.8×10² 130 IDL-C SBP (mmHg) LDL-C & HDL-C & TG independent 0.11 (-0.54; 0.77) 0.733 IVW < 0.001 9.0 191 IDL-C DBP (mmHg) Total 0.03 (-0.04; 0.10) 0.436 IVW < 0.001 7.4×10² 83 IDL-C DBP (mmHg) LDL-C independent 0.16 (-0.45; 0.77) 0.611 MR Egger < 0.001 1.0×10¹ 104 IDL-C DBP (mmHg) HDL-C independent 0.05 (-0.06; 0.15) 0.367 MR Egger < 0.001 3.5×10² 146 IDL-C DBP (mmHg) TG independent -0.15 (-0.27; -0.03) 0.012 MR Egger < 0.001 2.7×10² 127 IDL-C DBP (mmHg) LDL-C & HDL-C & TG independent 0.06 (-0.32; 0.44) 0.761 IVW < 0.001 2.7×10¹ 191 IDL-C PBL (OR) Total 2.25 (1.23; 4.14) 0.009 MR Egger 0.519 1.0×10¹ 59 IDL-C PBL (OR) LDL-C independent 1.20 (0.32; 4.48) 0.784 IVW 0.029 2.2 63 IDL-C PBL (OR) HDL-C independent 1.15 (0.95; 1.39) 0.150 IVW 0.247 1.1×10² 92 IDL-C PBL (OR) TG independent 0.97 (0.78; 1.21) 0.794 IVW 0.027 8.2×10¹ 86 IDL-C PBL (OR) LDL-C & HDL-C & TG independent 0.60 (0.22; 1.64) 0.316 MR Egger 0.057 3.8 119 IDL-C BUN (mg/dl) Total 0.00 (-0.00; 0.01) 0.230 IVW < 0.001 3.2×10⁵ 108 IDL-C BUN (mg/dl) LDL-C independent 0.05 (0.02; 0.07) < 0.001 IVW < 0.001 5.4×10³ 130 IDL-C BUN (mg/dl) HDL-C independent 0.00 (-0.00; 0.01) 0.071 IVW < 0.001 3.3×10⁵ 174 IDL-C BUN (mg/dl) TG independent 0.00 (-0.01; 0.01) 0.895 MR Egger < 0.001 1.3×10⁵ 164 IDL-C BUN (mg/dl) LDL-C & HDL-C & TG independent 0.02 (0.00; 0.04) 0.019 IVW < 0.001 1.1×10⁴ 230 IDL-C eGFR (SD of log(eGFR)) Total -0.00 (-0.00; 0.00) 0.479 IVW < 0.001 2.0×10⁶ 97 IDL-C eGFR (SD of log(eGFR)) LDL-C independent -0.00 (-0.01; 0.01) 0.729 IVW < 0.001 3.7×10⁴ 125 IDL-C eGFR (SD of log(eGFR)) HDL-C independent 0.00 (0.00; 0.00) 0.032 MR Egger < 0.001 1.1×10⁶ 168 IDL-C eGFR (SD of log(eGFR)) TG independent 0.00 (-0.00; 0.00) 0.868 IVW < 0.001 1.6×10⁶ 155 IDL-C eGFR (SD of log(eGFR)) LDL-C & HDL-C & TG independent -0.01 (-0.02; -0.00) 0.022 IVW < 0.001 7.5×10⁴ 226 IDL-C CKD (OR) Total 0.99 (0.95; 1.02) 0.500 IVW 0.006 3.0×10³ 111 IDL-C CKD (OR) LDL-C independent 0.92 (0.70; 1.19) 0.510 IVW 0.005 5.5×10¹ 134 IDL-C CKD (OR) HDL-C independent 0.92 (0.88; 0.97) 0.003 MR Egger 0.091 1.4×10³ 182 IDL-C CKD (OR) TG independent 0.98 (0.94; 1.02) 0.315 IVW < 0.001 2.4×10³ 169 IDL-C CKD (OR) LDL-C & HDL-C & TG independent 1.09 (0.91; 1.32) 0.348 IVW < 0.001 1.1×10² 242 IDL-C IBD (OR) Total 1.11 (1.04; 1.18) 0.002 IVW < 0.001 9.0×10² 109 IDL-C IBD (OR) LDL-C independent 0.20 (0.12; 0.34) < 0.001 MR Egger 0.036 1.4×10¹ 133 IDL-C IBD (OR) HDL-C independent 1.12 (1.05; 1.20) < 0.001 IVW < 0.001 9.0×10² 182 IDL-C IBD (OR) TG independent 1.20 (1.09; 1.32) < 0.001 MR Egger < 0.001 4.2×10² 168 IDL-C IBD (OR) LDL-C & HDL-C & TG independent 0.46 (0.33; 0.64) < 0.001 IVW < 0.001 3.6×10¹ 245 IDL-C UC (OR) Total 1.37 (1.15; 1.63) < 0.001 MR Egger 0.170 1.3×10² 117 IDL-C UC (OR) LDL-C independent 0.30 (0.15; 0.59) < 0.001 MR Egger 0.323 8.4 134 IDL-C UC (OR) HDL-C independent 1.07 (0.98; 1.15) 0.121 IVW < 0.001 6.0×10² 188 IDL-C UC (OR) TG independent 1.09 (1.00; 1.19) 0.051 IVW < 0.001 4.9×10² 173 IDL-C UC (OR) LDL-C & HDL-C & TG independent 0.38 (0.25; 0.57) < 0.001 IVW 0.011 2.3×10¹ 248 IDL-C CD (OR) Total 1.04 (0.86; 1.25) 0.698 MR Egger 0.002 1.1×10² 111 IDL-C CD (OR) LDL-C independent 0.25 (0.12; 0.51) < 0.001 IVW 0.160 7.6 136 IDL-C CD (OR) HDL-C independent 1.14 (1.04; 1.24) 0.005 IVW 0.033 4.9×10² 184 IDL-C CD (OR) TG independent 1.11 (1.01; 1.23) 0.032 IVW < 0.001 4.0×10² 171 IDL-C CD (OR) LDL-C & HDL-C & TG independent 0.53 (0.33; 0.86) 0.010 IVW 0.067 1.7×10¹ 248 IDL-C Arthritis (OR) Total 0.93 (0.86; 1.02) 0.123 IVW 0.008 5.1×10² 91 IDL-C Arthritis (OR) LDL-C independent 0.67 (0.34; 1.33) 0.249 IVW 0.014 8.1 107 IDL-C Arthritis (OR) HDL-C independent 0.96 (0.89; 1.04) 0.351 IVW 0.042 5.8×10² 151 IDL-C Arthritis (OR) TG independent 0.96 (0.87; 1.07) 0.458 IVW 0.040 3.6×10² 137 IDL-C Arthritis (OR) LDL-C & HDL-C & TG independent 0.97 (0.61; 1.55) 0.915 IVW 0.084 1.8×10¹ 195 IDL-C ALS (OR) Total 1.10 (1.04; 1.17) 0.002 IVW 0.368 9.8×10² 114 IDL-C ALS (OR) LDL-C independent 0.87 (0.52; 1.44) 0.578 IVW 0.367 1.5×10¹ 139 IDL-C ALS (OR) HDL-C independent 1.06 (1.00; 1.13) 0.053 IVW 0.543 1.1×10³ 187 IDL-C ALS (OR) TG independent 1.05 (0.97; 1.13) 0.192 IVW 0.079 6.7×10² 168 IDL-C ALS (OR) LDL-C & HDL-C & TG independent 0.76 (0.53; 1.08) 0.122 IVW 0.083 3.1×10¹ 250 IDL-C MS (OR) Total 1.08 (0.95; 1.22) 0.264 IVW 0.165 2.3×10² 25 IDL-C MS (OR) LDL-C independent 1.73 (0.84; 3.59) 0.138 IVW 0.296 7.3 24 IDL-C MS (OR) HDL-C independent 1.09 (0.97; 1.23) 0.135 IVW 0.016 2.9×10² 33 IDL-C MS (OR) TG independent 1.09 (0.95; 1.26) 0.229 IVW 0.095 1.9×10² 37 IDL-C MS (OR) LDL-C & HDL-C & TG independent 1.09 (0.52; 2.28) 0.814 MR Egger 0.005 7.1 40 IDL-C Alzheimer (OR) Total 1.06 (1.04; 1.08) < 0.001 MR Egger < 0.001 7.9×10³ 90 IDL-C Alzheimer (OR) LDL-C independent 0.75 (0.67; 0.83) < 0.001 MR Egger < 0.001 3.5×10² 96 IDL-C Alzheimer (OR) HDL-C independent 1.02 (1.01; 1.03) < 0.001 IVW < 0.001 3.5×10⁴ 153 IDL-C Alzheimer (OR) TG independent 1.03 (1.02; 1.04) < 0.001 IVW < 0.001 2.5×10⁴ 133 IDL-C Alzheimer (OR) LDL-C & HDL-C & TG independent 0.98 (0.93; 1.04) 0.573 MR Egger < 0.001 1.2×10³ 208 IDL-C Parkinson (OR) Total 0.92 (0.86; 0.99) 0.025 IVW 0.012 8.1×10² 112 IDL-C Parkinson (OR) LDL-C independent 2.28 (1.34; 3.88) 0.002 IVW 0.209 1.4×10¹ 134 IDL-C Parkinson (OR) HDL-C independent 0.93 (0.87; 1.00) 0.046 IVW 0.018 8.4×10² 181 IDL-C Parkinson (OR) TG independent 0.92 (0.85; 1.00) 0.056 IVW < 0.001 5.9×10² 168 IDL-C Parkinson (OR) LDL-C & HDL-C & TG independent 1.81 (1.25; 2.62) 0.002 IVW 0.009 2.8×10¹ 239 IDL-C Pancreatic cancer (OR) Total 1.04 (0.67; 1.61) 0.859 MR Egger 0.080 2.0×10¹ 115 IDL-C Pancreatic cancer (OR) LDL-C independent 0.12 (0.02; 0.58) 0.009 MR Egger 0.004 1.5 140 IDL-C Pancreatic cancer (OR) HDL-C independent 1.01 (0.84; 1.23) 0.884 IVW < 0.001 1.0×10² 187 IDL-C Pancreatic cancer (OR) TG independent 1.30 (1.01; 1.68) 0.041 IVW 0.056 5.9×10¹ 172 IDL-C Pancreatic cancer (OR) LDL-C & HDL-C & TG independent 0.92 (0.32; 2.69) 0.886 IVW < 0.001 3.4 247 IDL-C Colon cancer (OR) Total 1.04 (0.85; 1.26) 0.722 MR Egger 0.068 1.0×10² 115 IDL-C Colon cancer (OR) LDL-C independent 1.51 (0.76; 3.00) 0.235 MR Egger 0.024 8.2 140 IDL-C Colon cancer (OR) HDL-C independent 1.12 (1.04; 1.22) 0.005 IVW 0.002 5.9×10² 188 IDL-C Colon cancer (OR) TG independent 1.10 (0.99; 1.21) 0.063 IVW 0.002 4.0×10² 172 IDL-C Colon cancer (OR) LDL-C & HDL-C & TG independent 1.33 (0.86; 2.06) 0.202 IVW < 0.001 2.0×10¹ 251 IDL-C Rectal cancer (OR) Total 1.15 (1.03; 1.29) 0.016 IVW 0.823 2.9×10² 114 IDL-C Rectal cancer (OR) LDL-C independent 0.58 (0.23; 1.44) 0.237 MR Egger 0.792 4.6 139 IDL-C Rectal cancer (OR) HDL-C independent 1.19 (1.07; 1.33) 0.002 IVW 0.477 3.3×10² 186 IDL-C Rectal cancer (OR) TG independent 1.10 (0.97; 1.26) 0.136 IVW 0.621 2.3×10² 174 IDL-C Rectal cancer (OR) LDL-C & HDL-C & TG independent 0.72 (0.40; 1.30) 0.271 IVW 0.481 1.1×10¹ 249 IDL-C Melanoma (OR) Total 0.97 (0.90; 1.04) 0.341 IVW 0.155 8.2×10² 115 IDL-C Melanoma (OR) LDL-C independent 1.43 (0.85; 2.39) 0.177 IVW 0.007 1.4×10¹ 140 IDL-C Melanoma (OR) HDL-C independent 0.98 (0.92; 1.04) 0.514 IVW 0.004 1.0×10³ 185 IDL-C Melanoma (OR) TG independent 0.96 (0.88; 1.03) 0.265 IVW 0.074 6.1×10² 172 IDL-C Melanoma (OR) LDL-C & HDL-C & TG independent 1.35 (0.96; 1.88) 0.082 IVW < 0.001 3.4×10¹ 249 IDL-C Lung cancer (OR) Total 0.83 (0.75; 0.92) < 0.001 IVW 0.338 3.4×10² 115 IDL-C Lung cancer (OR) LDL-C independent 0.80 (0.34; 1.87) 0.608 IVW 0.190 5.3 141 IDL-C Lung cancer (OR) HDL-C independent 0.85 (0.76; 0.94) 0.002 IVW 0.100 3.3×10² 188 IDL-C Lung cancer (OR) TG independent 0.84 (0.74; 0.95) 0.006 IVW 0.185 2.4×10² 172 IDL-C Lung cancer (OR) LDL-C & HDL-C & TG independent 0.97 (0.54; 1.73) 0.908 IVW 0.062 1.1×10¹ 251