Exposure Outcome Effect type Point estimate (95%CI) P-value Estimator Heterogeneity P-value Precision No. variants Rem-chol CHD (OR) Total 1.67 (1.57; 1.79) < 0.001 IVW < 0.001 9.0×10² 14 Rem-chol CHD (OR) LDL-C independent 1.43 (1.28; 1.58) < 0.001 IVW < 0.001 3.5×10² 34 Rem-chol CHD (OR) HDL-C independent 1.45 (1.36; 1.54) < 0.001 IVW < 0.001 9.3×10² 32 Rem-chol CHD (OR) TG independent 1.44 (1.28; 1.62) < 0.001 IVW < 0.001 2.8×10² 25 Rem-chol CHD (OR) LDL-C & HDL-C & TG independent 1.04 (0.91; 1.20) 0.534 IVW < 0.001 2.0×10² 55 Rem-chol HF (OR) Total 1.11 (1.06; 1.16) < 0.001 IVW < 0.001 2.0×10³ 24 Rem-chol HF (OR) LDL-C independent 1.12 (1.04; 1.21) 0.002 IVW < 0.001 7.2×10² 90 Rem-chol HF (OR) HDL-C independent 1.05 (0.99; 1.11) 0.131 MR Egger < 0.001 1.1×10³ 92 Rem-chol HF (OR) TG independent 0.94 (0.87; 1.02) 0.162 MR Egger < 0.001 5.4×10² 71 Rem-chol HF (OR) LDL-C & HDL-C & TG independent 1.09 (1.02; 1.16) 0.014 IVW < 0.001 8.6×10² 184 Rem-chol AF (OR) Total 1.01 (0.97; 1.05) 0.588 IVW 0.287 2.2×10³ 24 Rem-chol AF (OR) LDL-C independent 1.06 (1.00; 1.13) 0.050 IVW 0.004 1.1×10³ 95 Rem-chol AF (OR) HDL-C independent 1.02 (0.98; 1.06) 0.265 IVW 0.102 2.7×10³ 94 Rem-chol AF (OR) TG independent 1.03 (0.96; 1.10) 0.410 MR Egger 0.006 8.4×10² 77 Rem-chol AF (OR) LDL-C & HDL-C & TG independent 1.07 (1.01; 1.13) 0.015 IVW < 0.001 1.2×10³ 191 Rem-chol Any stroke (OR) Total 1.23 (1.04; 1.45) 0.014 MR Egger 0.254 1.4×10² 25 Rem-chol Any stroke (OR) LDL-C independent 1.08 (0.99; 1.18) 0.089 IVW 0.004 4.8×10² 89 Rem-chol Any stroke (OR) HDL-C independent 1.03 (0.98; 1.08) 0.241 IVW < 0.001 1.6×10³ 94 Rem-chol Any stroke (OR) TG independent 1.07 (0.96; 1.19) 0.200 MR Egger 0.130 3.4×10² 77 Rem-chol Any stroke (OR) LDL-C & HDL-C & TG independent 1.00 (0.93; 1.09) 0.952 IVW < 0.001 6.1×10² 190 Rem-chol Any ischemic stroke (OR) Total 1.19 (1.00; 1.42) 0.044 MR Egger 0.379 1.3×10² 25 Rem-chol Any ischemic stroke (OR) LDL-C independent 1.03 (0.94; 1.14) 0.485 IVW 0.014 4.2×10² 88 Rem-chol Any ischemic stroke (OR) HDL-C independent 1.04 (0.98; 1.09) 0.191 IVW < 0.001 1.4×10³ 95 Rem-chol Any ischemic stroke (OR) TG independent 1.07 (0.96; 1.19) 0.243 MR Egger 0.712 3.4×10² 76 Rem-chol Any ischemic stroke (OR) LDL-C & HDL-C & TG independent 0.98 (0.90; 1.07) 0.719 IVW 0.005 5.2×10² 189 Rem-chol Large artery stroke (OR) Total 1.20 (1.03; 1.39) 0.020 IVW 0.221 1.7×10² 25 Rem-chol Large artery stroke (OR) LDL-C independent 1.09 (0.86; 1.38) 0.473 IVW < 0.001 6.9×10¹ 90 Rem-chol Large artery stroke (OR) HDL-C independent 1.09 (0.95; 1.24) 0.218 IVW 0.003 2.2×10² 94 Rem-chol Large artery stroke (OR) TG independent 1.35 (1.02; 1.77) 0.035 IVW 0.069 5.0×10¹ 77 Rem-chol Large artery stroke (OR) LDL-C & HDL-C & TG independent 0.76 (0.61; 0.93) 0.010 IVW 0.012 8.5×10¹ 191 Rem-chol Cardioembolic stroke (OR) Total 0.99 (0.89; 1.10) 0.876 IVW 0.652 3.3×10² 25 Rem-chol Cardioembolic stroke (OR) LDL-C independent 1.09 (0.91; 1.30) 0.335 IVW 0.006 1.2×10² 91 Rem-chol Cardioembolic stroke (OR) HDL-C independent 0.99 (0.90; 1.10) 0.920 IVW 0.735 3.7×10² 95 Rem-chol Cardioembolic stroke (OR) TG independent 0.94 (0.78; 1.14) 0.544 IVW 0.730 1.1×10² 78 Rem-chol Cardioembolic stroke (OR) LDL-C & HDL-C & TG independent 0.98 (0.83; 1.16) 0.782 IVW 0.008 1.4×10² 191 Rem-chol Small vessel stroke (OR) Total 1.05 (0.92; 1.19) 0.460 IVW 0.842 2.4×10² 25 Rem-chol Small vessel stroke (OR) LDL-C independent 1.24 (0.98; 1.57) 0.069 IVW 0.142 7.0×10¹ 92 Rem-chol Small vessel stroke (OR) HDL-C independent 0.96 (0.84; 1.09) 0.501 IVW 0.186 2.3×10² 95 Rem-chol Small vessel stroke (OR) TG independent 0.85 (0.67; 1.08) 0.189 MR Egger 0.026 6.8×10¹ 78 Rem-chol Small vessel stroke (OR) LDL-C & HDL-C & TG independent 1.10 (0.90; 1.34) 0.357 IVW 0.002 9.9×10¹ 193 Rem-chol cIMT (mm) Total 0.01 (0.00; 0.01) 0.003 IVW < 0.001 2.5×10⁵ 23 Rem-chol cIMT (mm) LDL-C independent -0.01 (-0.01; 0.00) 0.096 IVW 0.007 1.0×10⁵ 93 Rem-chol cIMT (mm) HDL-C independent 0.00 (0.00; 0.01) 0.012 IVW < 0.001 2.7×10⁵ 93 Rem-chol cIMT (mm) TG independent 0.02 (0.01; 0.02) < 0.001 IVW 0.002 8.8×10⁴ 79 Rem-chol cIMT (mm) LDL-C & HDL-C & TG independent -0.00 (-0.01; 0.01) 0.676 MR Egger < 0.001 8.9×10⁴ 194 Rem-chol Carotid plaque (OR) Total 1.34 (1.23; 1.47) < 0.001 IVW 0.016 4.5×10² 24 Rem-chol Carotid plaque (OR) LDL-C independent 1.12 (0.97; 1.29) 0.110 IVW 0.031 1.9×10² 93 Rem-chol Carotid plaque (OR) HDL-C independent 1.30 (1.18; 1.42) < 0.001 IVW 0.010 4.7×10² 92 Rem-chol Carotid plaque (OR) TG independent 1.56 (1.32; 1.83) < 0.001 IVW 0.042 1.5×10² 75 Rem-chol Carotid plaque (OR) LDL-C & HDL-C & TG independent 1.18 (1.02; 1.36) 0.022 IVW 0.012 1.9×10² 189 Rem-chol Glucose (mmol/l) Total -0.00 (-0.02; 0.01) 0.781 IVW 0.040 1.5×10⁴ 25 Rem-chol Glucose (mmol/l) LDL-C independent 0.00 (-0.03; 0.03) 0.853 IVW 0.060 4.5×10³ 87 Rem-chol Glucose (mmol/l) HDL-C independent 0.01 (-0.00; 0.03) 0.180 IVW < 0.001 1.7×10⁴ 89 Rem-chol Glucose (mmol/l) TG independent -0.03 (-0.06; -0.00) 0.028 IVW < 0.001 5.2×10³ 73 Rem-chol Glucose (mmol/l) LDL-C & HDL-C & TG independent 0.00 (-0.02; 0.03) 0.736 IVW < 0.001 6.3×10³ 178 Rem-chol HbA1c (mmol/mol) Total 0.08 (-0.19; 0.36) 0.545 MR Egger < 0.001 5.2×10¹ 21 Rem-chol HbA1c (mmol/mol) LDL-C independent 0.02 (-0.11; 0.16) 0.727 IVW < 0.001 2.1×10² 85 Rem-chol HbA1c (mmol/mol) HDL-C independent -0.03 (-0.11; 0.05) 0.430 IVW < 0.001 6.0×10² 85 Rem-chol HbA1c (mmol/mol) TG independent -0.19 (-0.34; -0.05) 0.008 IVW < 0.001 1.9×10² 69 Rem-chol HbA1c (mmol/mol) LDL-C & HDL-C & TG independent -0.00 (-0.13; 0.13) 0.987 IVW < 0.001 2.3×10² 175 Rem-chol T2DM (OR) Total 0.97 (0.94; 1.01) 0.166 IVW 0.007 2.9×10³ 22 Rem-chol T2DM (OR) LDL-C independent 1.12 (1.06; 1.18) < 0.001 MR Egger < 0.001 1.3×10³ 83 Rem-chol T2DM (OR) HDL-C independent 1.02 (0.99; 1.05) 0.243 IVW < 0.001 3.5×10³ 84 Rem-chol T2DM (OR) TG independent 0.87 (0.81; 0.93) < 0.001 IVW < 0.001 8.5×10² 57 Rem-chol T2DM (OR) LDL-C & HDL-C & TG independent 1.00 (0.95; 1.06) 0.939 IVW < 0.001 1.3×10³ 165 Rem-chol CRP (mg/L) Total -0.47 (-0.78; -0.16) 0.003 MR Egger < 0.001 4.0×10¹ 14 Rem-chol CRP (mg/L) LDL-C independent 0.12 (0.01; 0.23) 0.030 IVW < 0.001 3.2×10² 65 Rem-chol CRP (mg/L) HDL-C independent -0.00 (-0.09; 0.08) 0.910 MR Egger 0.005 5.5×10² 82 Rem-chol CRP (mg/L) TG independent -0.19 (-0.30; -0.08) < 0.001 IVW < 0.001 3.1×10² 61 Rem-chol CRP (mg/L) LDL-C & HDL-C & TG independent 0.10 (0.01; 0.19) 0.031 IVW < 0.001 4.5×10² 165 Rem-chol SBP (mmHg) Total 1.70 (1.06; 2.34) < 0.001 MR Egger 0.106 9.3 21 Rem-chol SBP (mmHg) LDL-C independent 0.81 (0.54; 1.09) < 0.001 IVW < 0.001 5.1×10¹ 79 Rem-chol SBP (mmHg) HDL-C independent 0.52 (0.36; 0.69) < 0.001 IVW < 0.001 1.3×10² 84 Rem-chol SBP (mmHg) TG independent 0.62 (0.32; 0.92) < 0.001 IVW 0.006 4.2×10¹ 66 Rem-chol SBP (mmHg) LDL-C & HDL-C & TG independent 0.39 (0.12; 0.65) 0.005 MR Egger < 0.001 5.3×10¹ 171 Rem-chol DBP (mmHg) Total 0.26 (0.16; 0.37) < 0.001 IVW < 0.001 3.5×10² 20 Rem-chol DBP (mmHg) LDL-C independent 0.15 (-0.02; 0.31) 0.078 IVW < 0.001 1.4×10² 76 Rem-chol DBP (mmHg) HDL-C independent 0.04 (-0.06; 0.13) 0.451 IVW < 0.001 4.2×10² 81 Rem-chol DBP (mmHg) TG independent -0.12 (-0.31; 0.06) 0.198 MR Egger < 0.001 1.1×10² 64 Rem-chol DBP (mmHg) LDL-C & HDL-C & TG independent -0.08 (-0.22; 0.07) 0.291 IVW < 0.001 1.9×10² 163 Rem-chol PBL (OR) Total 1.03 (0.36; 2.95) 0.963 MR Egger 0.004 3.4 17 Rem-chol PBL (OR) LDL-C independent 0.87 (0.63; 1.19) 0.367 IVW 0.002 3.9×10¹ 55 Rem-chol PBL (OR) HDL-C independent 1.01 (0.83; 1.23) 0.908 IVW 0.005 9.9×10¹ 58 Rem-chol PBL (OR) TG independent 0.69 (0.47; 1.02) 0.064 IVW 0.019 2.6×10¹ 46 Rem-chol PBL (OR) LDL-C & HDL-C & TG independent 0.80 (0.56; 1.15) 0.226 IVW 0.003 3.0×10¹ 112 Rem-chol BUN (mg/dl) Total -0.00 (-0.01; 0.00) 0.168 IVW < 0.001 1.6×10⁵ 24 Rem-chol BUN (mg/dl) LDL-C independent -0.00 (-0.01; 0.01) 0.859 IVW < 0.001 7.0×10⁴ 89 Rem-chol BUN (mg/dl) HDL-C independent -0.00 (-0.01; 0.00) 0.555 IVW < 0.001 1.7×10⁵ 89 Rem-chol BUN (mg/dl) TG independent -0.01 (-0.02; -0.00) 0.025 IVW < 0.001 5.8×10⁴ 76 Rem-chol BUN (mg/dl) LDL-C & HDL-C & TG independent -0.01 (-0.01; 0.00) 0.159 IVW < 0.001 6.9×10⁴ 185 Rem-chol eGFR (SD of log(eGFR)) Total 0.00 (-0.00; 0.00) 0.503 IVW < 0.001 9.9×10⁵ 23 Rem-chol eGFR (SD of log(eGFR)) LDL-C independent 0.00 (-0.00; 0.01) 0.103 MR Egger < 0.001 4.0×10⁵ 87 Rem-chol eGFR (SD of log(eGFR)) HDL-C independent -0.00 (-0.00; 0.00) 0.244 IVW < 0.001 1.1×10⁶ 89 Rem-chol eGFR (SD of log(eGFR)) TG independent 0.00 (0.00; 0.01) 0.011 IVW < 0.001 2.9×10⁵ 68 Rem-chol eGFR (SD of log(eGFR)) LDL-C & HDL-C & TG independent 0.00 (0.00; 0.01) 0.013 MR Egger < 0.001 3.6×10⁵ 178 Rem-chol CKD (OR) Total 1.00 (0.95; 1.05) 0.994 IVW 0.040 1.5×10³ 25 Rem-chol CKD (OR) LDL-C independent 0.98 (0.91; 1.07) 0.700 IVW 0.009 5.9×10² 92 Rem-chol CKD (OR) HDL-C independent 1.01 (0.94; 1.08) 0.838 MR Egger 0.032 8.4×10² 92 Rem-chol CKD (OR) TG independent 0.92 (0.84; 1.01) 0.087 IVW < 0.001 4.6×10² 76 Rem-chol CKD (OR) LDL-C & HDL-C & TG independent 1.02 (0.94; 1.11) 0.571 IVW < 0.001 6.0×10² 188 Rem-chol IBD (OR) Total 0.97 (0.88; 1.06) 0.460 IVW 0.009 4.5×10² 25 Rem-chol IBD (OR) LDL-C independent 0.92 (0.79; 1.06) 0.224 IVW 0.012 1.9×10² 93 Rem-chol IBD (OR) HDL-C independent 0.97 (0.89; 1.05) 0.429 IVW 0.004 5.5×10² 95 Rem-chol IBD (OR) TG independent 1.07 (0.91; 1.27) 0.419 IVW < 0.001 1.4×10² 77 Rem-chol IBD (OR) LDL-C & HDL-C & TG independent 0.93 (0.80; 1.07) 0.292 IVW < 0.001 1.8×10² 190 Rem-chol UC (OR) Total 1.04 (0.92; 1.18) 0.520 IVW 0.772 2.5×10² 24 Rem-chol UC (OR) LDL-C independent 0.98 (0.80; 1.21) 0.863 MR Egger 0.095 9.1×10¹ 94 Rem-chol UC (OR) HDL-C independent 0.99 (0.89; 1.10) 0.813 IVW 0.008 3.5×10² 96 Rem-chol UC (OR) TG independent 1.04 (0.84; 1.28) 0.748 IVW 0.005 8.7×10¹ 78 Rem-chol UC (OR) LDL-C & HDL-C & TG independent 0.88 (0.73; 1.05) 0.151 IVW < 0.001 1.2×10² 192 Rem-chol CD (OR) Total 1.00 (0.88; 1.14) 0.967 IVW 0.009 2.4×10² 25 Rem-chol CD (OR) LDL-C independent 0.91 (0.74; 1.12) 0.382 IVW 0.384 9.2×10¹ 92 Rem-chol CD (OR) HDL-C independent 1.02 (0.89; 1.16) 0.796 IVW 0.135 2.3×10² 94 Rem-chol CD (OR) TG independent 1.04 (0.83; 1.30) 0.762 IVW 0.003 7.5×10¹ 78 Rem-chol CD (OR) LDL-C & HDL-C & TG independent 1.06 (0.87; 1.29) 0.582 IVW 0.049 9.5×10¹ 189 Rem-chol Arthritis (OR) Total 1.02 (0.89; 1.17) 0.782 IVW 0.081 2.1×10² 23 Rem-chol Arthritis (OR) LDL-C independent 1.10 (0.92; 1.31) 0.302 MR Egger 0.013 1.2×10² 82 Rem-chol Arthritis (OR) HDL-C independent 1.05 (0.94; 1.19) 0.368 IVW 0.375 2.8×10² 80 Rem-chol Arthritis (OR) TG independent 1.14 (0.94; 1.39) 0.184 IVW 0.267 9.9×10¹ 71 Rem-chol Arthritis (OR) LDL-C & HDL-C & TG independent 1.14 (0.95; 1.37) 0.170 MR Egger 0.035 1.1×10² 167 Rem-chol ALS (OR) Total 1.12 (1.02; 1.23) 0.022 IVW 0.683 4.3×10² 25 Rem-chol ALS (OR) LDL-C independent 0.94 (0.81; 1.09) 0.431 MR Egger 0.517 1.7×10² 94 Rem-chol ALS (OR) HDL-C independent 1.02 (0.93; 1.11) 0.666 IVW 0.662 4.9×10² 95 Rem-chol ALS (OR) TG independent 1.12 (0.93; 1.35) 0.234 IVW 0.104 1.1×10² 75 Rem-chol ALS (OR) LDL-C & HDL-C & TG independent 0.83 (0.72; 0.96) 0.013 IVW 0.471 1.8×10² 188 Rem-chol MS (OR) Total 0.93 (0.80; 1.07) 0.320 IVW 0.669 1.8×10² 9 Rem-chol MS (OR) LDL-C independent 0.66 (0.49; 0.90) 0.008 MR Egger 0.309 4.0×10¹ 24 Rem-chol MS (OR) HDL-C independent 0.92 (0.79; 1.08) 0.320 IVW 0.133 1.5×10² 21 Rem-chol MS (OR) TG independent 1.12 (0.86; 1.48) 0.397 IVW 0.941 5.2×10¹ 19 Rem-chol MS (OR) LDL-C & HDL-C & TG independent 0.91 (0.63; 1.30) 0.592 IVW 0.007 3.0×10¹ 38 Rem-chol Alzheimer (OR) Total 0.99 (0.89; 1.10) 0.854 MR Egger 0.220 3.6×10² 15 Rem-chol Alzheimer (OR) LDL-C independent 0.98 (0.94; 1.01) 0.205 IVW < 0.001 3.1×10³ 52 Rem-chol Alzheimer (OR) HDL-C independent 1.00 (0.98; 1.01) 0.865 IVW 0.434 2.0×10⁴ 83 Rem-chol Alzheimer (OR) TG independent 1.02 (1.00; 1.05) 0.105 IVW 0.177 5.6×10³ 69 Rem-chol Alzheimer (OR) LDL-C & HDL-C & TG independent 0.99 (0.97; 1.02) 0.650 MR Egger < 0.001 4.9×10³ 146 Rem-chol Parkinson (OR) Total 1.37 (1.00; 1.88) 0.051 MR Egger 0.480 3.8×10¹ 24 Rem-chol Parkinson (OR) LDL-C independent 1.12 (0.95; 1.33) 0.183 IVW 0.076 1.3×10² 92 Rem-chol Parkinson (OR) HDL-C independent 1.09 (0.99; 1.20) 0.076 IVW 0.548 4.3×10² 92 Rem-chol Parkinson (OR) TG independent 1.24 (1.05; 1.47) 0.013 IVW 0.044 1.3×10² 78 Rem-chol Parkinson (OR) LDL-C & HDL-C & TG independent 1.23 (1.05; 1.44) 0.009 IVW 0.005 1.6×10² 190 Rem-chol Pancreatic cancer (OR) Total 0.89 (0.66; 1.20) 0.447 IVW 0.565 4.2×10¹ 25 Rem-chol Pancreatic cancer (OR) LDL-C independent 0.42 (0.26; 0.70) < 0.001 IVW 0.003 1.5×10¹ 91 Rem-chol Pancreatic cancer (OR) HDL-C independent 0.71 (0.52; 0.96) 0.029 IVW 0.058 4.0×10¹ 92 Rem-chol Pancreatic cancer (OR) TG independent 1.17 (0.69; 1.99) 0.564 IVW 0.611 1.4×10¹ 76 Rem-chol Pancreatic cancer (OR) LDL-C & HDL-C & TG independent 0.54 (0.33; 0.88) 0.014 IVW < 0.001 1.6×10¹ 186 Rem-chol Colon cancer (OR) Total 1.63 (1.06; 2.51) 0.026 MR Egger 0.301 2.1×10¹ 24 Rem-chol Colon cancer (OR) LDL-C independent 1.02 (0.83; 1.27) 0.829 MR Egger 0.010 8.5×10¹ 90 Rem-chol Colon cancer (OR) HDL-C independent 1.03 (0.90; 1.18) 0.617 IVW 0.115 2.1×10² 92 Rem-chol Colon cancer (OR) TG independent 1.26 (0.98; 1.62) 0.069 IVW 0.072 6.2×10¹ 76 Rem-chol Colon cancer (OR) LDL-C & HDL-C & TG independent 1.09 (0.88; 1.34) 0.424 IVW 0.010 9.0×10¹ 185 Rem-chol Rectal cancer (OR) Total 1.18 (1.00; 1.40) 0.055 IVW 0.469 1.3×10² 25 Rem-chol Rectal cancer (OR) LDL-C independent 1.05 (0.80; 1.38) 0.722 IVW 0.908 5.3×10¹ 91 Rem-chol Rectal cancer (OR) HDL-C independent 1.11 (0.93; 1.33) 0.257 IVW 0.081 1.2×10² 91 Rem-chol Rectal cancer (OR) TG independent 1.22 (0.91; 1.64) 0.190 IVW 0.591 4.3×10¹ 76 Rem-chol Rectal cancer (OR) LDL-C & HDL-C & TG independent 1.02 (0.77; 1.34) 0.903 IVW 0.375 5.0×10¹ 186 Rem-chol Melanoma (OR) Total 0.97 (0.88; 1.07) 0.504 IVW 0.007 4.1×10² 25 Rem-chol Melanoma (OR) LDL-C independent 1.05 (0.90; 1.22) 0.547 IVW 0.048 1.7×10² 92 Rem-chol Melanoma (OR) HDL-C independent 1.05 (0.96; 1.14) 0.329 IVW 0.002 4.8×10² 90 Rem-chol Melanoma (OR) TG independent 0.78 (0.65; 0.92) 0.003 IVW 0.040 1.3×10² 75 Rem-chol Melanoma (OR) LDL-C & HDL-C & TG independent 1.12 (0.96; 1.31) 0.152 IVW < 0.001 1.6×10² 187 Rem-chol Lung cancer (OR) Total 0.88 (0.76; 1.03) 0.118 IVW 0.675 1.6×10² 25 Rem-chol Lung cancer (OR) LDL-C independent 1.01 (0.78; 1.30) 0.954 IVW 0.317 5.9×10¹ 92 Rem-chol Lung cancer (OR) HDL-C independent 0.92 (0.79; 1.06) 0.242 IVW 0.016 1.9×10² 93 Rem-chol Lung cancer (OR) TG independent 0.67 (0.50; 0.90) 0.008 MR Egger 0.939 4.5×10¹ 76 Rem-chol Lung cancer (OR) LDL-C & HDL-C & TG independent 1.11 (0.85; 1.44) 0.449 IVW 0.275 5.5×10¹ 187