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. Author manuscript; available in PMC: 2014 Jan 10.
Published in final edited form as: J Neurosci. 2013 Jul 10;33(28):11703–11714. doi: 10.1523/JNEUROSCI.1631-13.2013

Figure 1. Schematic representation of the electrophysiological experimental design.

Figure 1

(A) Sequences of 105 percutaneous electrical stimulations (0.66 Hz at 3 times the C-fiber threshold intensity) were applied to the excitatory receptive field. The DNIC were triggered by alternately immersing one hindpaw into a 49°C water bath (B) or applying a 300 g mechanical pressure (C) on the other hindpaw between the 36th and 60th electrical stimuli (corresponding to 37.5 seconds). DAMGO (5 μg in 10 μl) or Dlt II (8 μg in 10 μl) was injected to the lumbar spinal cord via an intrathecal catheter. (B and C) Histograms showing the C-fiber-evoked responses of trigeminal WDR neurons to 105 successive electrical stimulations. (B) Effect of the noxious heat stimulus on the C-fiber-evoked response of a trigeminal WDR neuron. (C) Effect of the noxious mechanical stimulus on the C-fiber-evoked response of a trigeminal WDR neuron.