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. Author manuscript; available in PMC: 2015 Jun 5.
Published in final edited form as: Cell Mol Life Sci. 2012 Sep 28;70(13):2319–2329. doi: 10.1007/s00018-012-1171-6

Figure 3. Mixing-and-matching tyrosine phosphorylation sites in Dab1 by alternative splicing.

Figure 3

Schematic representation of exon-intron structure (exons 6 to 9) of the Dab1 gene. White boxes represent constitutive exons, whereas purple and gold boxes indicate alternative exons. The amino acid sequences of the four consensus Dab1 tyrosine phosphorylation sites are shown. Dab1 contains two YQXI motifs (Y185QTI and Y198QYI, framed in magenta) and two YXVP motifs (Y220QVP and Y232DVP, framed in green). Exclusion of exon 7 (ΔEx 7) removes Y198Q but links Y185Q to Y199I200, thereby reconstituting a Y185QYI motif identical to the original Y198QYI. Exclusion of exon 8 (ΔEx 8) removes Y220Q but connects Y198Q with V222P223, converting Y198QXI into a Y198QVP site. Exclusion of exons 7 and 8 (ΔEx 7&8) removes both Y198Q and Y220Q and rejoins Y185Q to V222P223, resulting in loss of both YQXI motifs but retention of two YXVP motifs.