Table 1.
Important genes identified by RNA-sequencing that were found to be differentially regulated after IFN-λ4 treatment to differentiating monocyte-derived macrophages (MDMs)
| Sl. no. | Gene symbol | Gene name | Fold change | P-value | FDR |
|---|---|---|---|---|---|
| 1 | TBC1D3K | TBC1 domain family; member 3K | 257.8223 | 5.60E-14 | 1.11E-10 |
| 2 | EGLN3 | Egl-9 family hypoxia-inducible factor 3 | 3.896497 | 4.30E-07 | 0.000295 |
| 3 | ADGRG2 | Adhesion G protein-coupled receptor G2 | 3.411812 | 4.44E-07 | 0.000295 |
| 4 | WFDC21P | WAP four-disulfide core domain 21 pseudogene | 3.014217 | 1.78E-11 | 3.03E-08 |
| 5 | CCL15 | Chemokine (C-C motif) ligand 15 | 2.713814 | 1.49E-16 | 8.90E-13 |
| 6 | SYNPO2 | Synaptopodin 2 | 2.366099 | 4.39E-06 | 0.001806 |
| 7 | CD1B | CD1b molecule | 2.346925 | 7.42E-05 | 0.017039 |
| 8 | IGFBP6 | Insulin-like growth factor binding protein 6 | 2.243955 | 4.46E-06 | 0.001806 |
| 9 | HCAR2 | Hydroxycarboxylic acid receptor 2 | 2.227582 | 6.71E-08 | 6.68E-05 |
| 10 | CXCL9 | Chemokine (C-X-C motif) ligand 9 | 2.186737 | 1.45E-05 | 0.005083 |
| 11 | PLTP | Phospholipid transfer protein | 2.176644 | 8.86E-08 | 8.14E-05 |
| 12 | MMP12 | Matrix metallopeptidase 12 | 2.136513 | 3.25E-05 | 0.009024 |
| 13 | SYNC | Syncoilin intermediate filament protein | 1.90768 | 0.000103 | 0.019723 |
| 14 | TNF | TNF | 1.823091 | 2.59E-06 | 0.001236 |
| 15 | HCAR3 | Hydroxycarboxylic acid receptor 3 | 1.818278 | 9.75E-05 | 0.019723 |
| 16 | COL1A1 | Collagen type I alpha 1 | 1.790855 | 4.54E-06 | 0.001806 |
| 17 | RAB30 | RAB30 member RAS oncogene family | 1.729061 | 0.000104 | 0.019723 |
| 18 | IL32 | IL-32 | 1.717923 | 2.83E-06 | 0.001301 |
| 19 | BCL2L14 | BCL2-like 14 (apoptosis facilitator) | 1.69596 | 2.40E-06 | 0.001195 |
| 20 | CCL17 | Chemokine (C-C motif) ligand 17 | 1.682015 | 0.000846 | 0.087868 |
| 21 | MMP19 | Matrix metallopeptidase 19 | −1.50139 | 0.000943 | 0.09533 |
| 22 | RIN2 | Ras and Rab interactor 2 | −1.50921 | 0.000283 | 0.041659 |
| 23 | DSC2 | Desmocollin 2 | −1.59525 | 0.000109 | 0.020065 |
| 24 | CD14 | CD14 molecule | −1.63661 | 0.000815 | 0.086052 |
| 25 | GEM | GTP binding protein overexpressed in skeletal muscle | −1.77586 | 3.82E-06 | 0.00169 |
| 26 | S100A8 | S100 calcium binding protein A8 | −1.78739 | 0.000108 | 0.020065 |
| 27 | S100A9 | S100 calcium binding protein A9 | −1.90406 | 2.92E-05 | 0.008483 |
| 28 | MMP10 | Matrix metallopeptidase 10 | −1.93753 | 0.000251 | 0.039372 |
| 29 | TNFRSF21 | TNF receptor superfamily; member 21 | −1.93923 | 4.99E-08 | 5.42E-05 |
| 30 | CDH23 | Cadherin-related 23 | −2.01853 | 1.99E-07 | 0.000158 |
| 31 | MMP1 | Matrix metallopeptidase 1 | −2.0201 | 0.000457 | 0.06061 |
| 31 | CCR1 | Complement component (3b/4b) receptor 1 (Knops blood group) | −2.02921 | 4.09E-08 | 4.88E-05 |
| 33 | SDC3 | Syndecan 3 | −2.03712 | 1.71E-05 | 0.005516 |
| 34 | THRB | Thyroid hormone receptor beta | −2.06934 | 2.99E-05 | 0.008483 |
| 35 | CCNA1 | Cyclin A1 | −2.11411 | 1.82E-06 | 0.001034 |
| 36 | CD163 | CD163 molecule | −2.31895 | 0.000478 | 0.061497 |
| 37 | MMP8 | Matrix metallopeptidase 8 | −2.32052 | 2.49E-05 | 0.007434 |
| 38 | VCAN | Versican | −2.51837 | 2.20E-06 | 0.001142 |
| 39 | DYSF | Dysferlin | −2.73433 | 6.34E-11 | 9.46E-08 |
| 40 | COL22A1 | Collagen; type XXII; alpha 1 | −3.17478 | 4.57E-09 | 6.06E-06 |
| 41 | MUCL1 | Mucin-like 1 | −3.36178 | 2.15E-06 | 0.001142 |
| 42 | FCMR | Fc fragment of IgM receptor | −3.43339 | 2.58E-16 | 1.02E-12 |
| 43 | SCIN | Scinderin | −4.48021 | 3.27E-14 | 8.25E-11 |