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. Author manuscript; available in PMC: 2021 May 27.
Published in final edited form as: J Hum Genet. 2021 Jan 20;66(6):625–636. doi: 10.1038/s10038-020-00895-6

Figure 2.

Figure 2

Tissue-specific association of cortisol-related SNPs with gene expression in STARNET. (a) LocusZoom plot showing genomic loci of given SNPs against measure of significance (-log10 (p-value)) for an eQTL analysis in liver for all SNPs within 100 Kb of SERPINA6. Squares represent the 21 significant cis-eQTLs (q ≤ 0.05) that are also at genome wide significance in CORNET (p ≤ 5≤10−8). (b) Genotypic effect of representative SNP for LD block 2 (rs2736898) on SERPINA6 gene expression in liver. (c) Global tissue specific effects on gene expression for rs2736898 represented as Q-Q plots for genes in liver, subcutaneous fat and visceral abdominal fat describing observed p-values vs those expected by chance. Deviation from expected uniform distribution described by Kolmogorov-Smirnov test p-value (Ks-test).