Table 2.
GO and MP terms overrepresented among FMRP targets derived from mouse cortex which capture a significant (Padj < 0.05) portion of the common variant genetic association with schizophrenia. Shown are effect sizes (Beta) and P-values (P) in gene set association analysis of genes targeted, or not targeted, by FMRP. P-values were Bonferroni adjusted (P.adj) for 35 terms.
| Term | Genes not FMRP targets | Genes FMRP targets | ||||||
|---|---|---|---|---|---|---|---|---|
| N | Beta | P | P .adj | N | Beta | P | P .adj | |
| Calcium ion transmembrane transporter activity (GO:0015085) | 91 | 0.419 | 4.7 × 10-4 | 0.017 | 25 | 1.080 | 6.9 × 10-6 | 2.4 × 10-4 |
| Abnormal motor coordination/balance (MP:0001516) | 538 | 0.104 | 0.028 | 0.97 | 117 | 0.463 | 2.8 × 10-5 | 9.6 × 10-4 |
| Abnormal seizure response to inducing agent (MP:0009357) | 125 | 0.190 | 0.043 | 1.0 | 42 | 0.710 | 1.1 × 10-4 | 0.0038 |
| Abnormal spatial learning (MP:0001463) | 141 | 0.161 | 0.057 | 1.0 | 61 | 0.569 | 1.4 × 10-4 | 0.0049 |
| Growth cone (GO:0030426) | 50 | 0.245 | 0.077 | 1.0 | 27 | 0.854 | 1.7 × 10-4 | 0.0060 |
| Abnormal nest building behaviour (MP:0001447) | 15 | 0.265 | 0.22 | 1.0 | 12 | 1.290 | 2.0 × 10-4 | 0.0071 |
| Abnormal excitatory postsynaptic currents (MP:0002910) | 60 | 0.177 | 0.12 | 1.0 | 35 | 0.715 | 3.5 × 10-4 | 0.012 |
| Axon part (GO:0033267) | 108 | 0.134 | 0.12 | 1.0 | 54 | 0.505 | 6.6 × 10-4 | 0.023 |