Table 3.

Partitioning FMRP targets common variant association by overrepresented functional annotation. Analyses were performed using a background of brain-expressed genes to account for background association. Shown are the effect sizes (β) and P-values (P) from gene set association analyses using MAGMA. For each disorder, P-values were adjusted for 3 genes sets using the Bonferroni method. Data for schizophrenia are repeated from Table 1.

Gene set	N	Schizophrenia		Bipolar disorder		Major depressive disorder
		β	P	β	P	β	P
Genes exclusive to functional terms	1195	0.066	0.13	0.37	0.38	0.031	0.49
Overlapping genes	401	0.29	3.7 × 10-6	0.23	1.6 × 10-5	0.21	9.7 × 10-5
Genes exclusive to FMRP targets	438	0.17	0.0063	0.14	0.0074	0.15	0.0026