Table 2.

Non-linear Mendelian randomization estimates for the association between systolic blood pressure and incident cardiovascular outcomes. Reference is made to a population mean systolic blood pressure value of 136.5mmHg and a population mean diastolic blood pressure value of 81.8mmHg.

Blood pressure		Cardiovascular disease		Coronary artery disease		Stroke
		Hazard ratio	95% confidence interval	Hazard ratio	95% confidence interval	Hazard ratio	95% confidence interval
Systolic blood pressure (mmHg)	min (102.9)	0.28	0.23-0.33	0.21	0.15-0.29	0.42	0.29-0.63
	110	0.36	0.32-0.42	0.3	0.24-0.39	0.49	0.36-0.68
	120	0.53	0.49-0.58	0.49	0.43-0.57	0.62	0.50-0.77
	130	0.78	0.75-0.81	0.77	0.73-0.81	0.82	0.75-0.90
	140	1.14	1.12-1.17	1.16	1.12-1.20	1.13	1.07-1.19
	150	1.67	1.56-1.80	1.7	1.52-1.90	1.63	1.30-2.05
	160	2.45	2.16-2.78	2.43	2.02-2.93	2.49	1.64-3.79
	170	3.59	2.99-4.30	3.41	2.64-4.39	4.02	2.12-7.61
	180	5.25	4.16-6.64	4.68	3.40-6.44	6.87	2.84-16.63
	190	7.69	5.76-10.26	6.32	4.31-9.26	12.55	3.93-40.10
	max (194.6)	9.15	6.69-12.52	7.16	4.76-10.76	16.65	4.58-60.56
Diastolic blood pressure (mmHg)	min (58.6)	0.2	0.15-0.25	0.14	0.09-0.23	0.3	0.16-0.52
	60	0.22	0.17-0.28	0.17	0.11-0.26	0.31	0.18-0.54
	65	0.32	0.27-0.39	0.28	0.21-0.38	0.39	0.25-0.62
	70	0.47	0.41-0.53	0.44	0.36-0.54	0.51	0.37-0.70
	75	0.65	0.61-0.70	0.64	0.58-0.72	0.67	0.55-0.81
	80	0.9	0.88-0.91	0.9	0.87-0.92	0.9	0.85-0.95
	85	1.21	1.17-1.24	1.21	1.15-1.26	1.23	1.11-1.35
	90	1.6	1.48-1.72	1.57	1.41-1.75	1.71	1.32-2.21
	95	2.08	1.85-2.35	1.99	1.68-2.35	2.42	1.58-3.70
	100	2.68	2.28-3.14	2.45	1.97-3.06	3.5	1.92-6.39
	105	3.4	2.78-4.15	2.97	2.28-3.88	5.16	2.35-11.34
	max (111.7)	4.6	3.58-5.89	3.72	2.70-5.14	8.88	3.11-25.27