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. Author manuscript; available in PMC: 2021 Jun 14.
Published in final edited form as: Oncogene. 2021 May 12;40(23):3929–3941. doi: 10.1038/s41388-021-01798-2

Figure 2. ERK5 is overexpressed in TNBC and its overexpression strongly correlates with poor prognosis.

Figure 2

(A) The level of Erk5 transcript was analyzed in 416 luminal/HER2+ tumors and 98 TNBC from TCGA dataset. Black lines in each group indicate median with interquartile range. (B) Kaplan-Meier analysis of distant metastasis-free survival of TNBC patients. Samples were divided into two groups with high (red) and low (black) expression of ERK5. Hazard ratio (HR) and logrank P values are shown. (C) A biopsy of human invasive ductal carcinoma and adjacent normal breast tissue (patient #481) was stained with H&E or with a specific antibody to ERK5 (brown). Scale bars: (2.5x) 500 μm, (10x) 100 μm, (40x) 20 μm.