Table 1. Main senescence-related processes and proteins covered in the review.
| Proteins/Protein complexess | ||
|---|---|---|
| ROS-driven pathways | 2 | p16/pRB, p53/p21 |
| Mitophagy | 2 | BNIP3, BNIP3L/Nix, PINK/Parkin, FUNDC1 |
| Ca2+ signalling/ROS | 3 | MCU |
| Mitochondria-lysosome | 3 | AMPK, RAB7, vCLAMP, Vps13-Mcp1, Vps39-ypt7-Tom40 |
| Mitophagy, autophagy and general proteostasis | 4 | Insulin, IGF-1, DIRAS3, Akt, mTORC1 |
| Ribosome biogenesis and protein synthesis | 4 | Pol I, mTOR, SirT1, eNoSC, METTL5, 4EBP, elF4G, |
| Tumour suppressor loss, oncogene activation | 5 | Sprouty1, Ras, DIRAS3, PI3K, Akt, mTORC1 |