. Author manuscript; available in PMC: 2021 May 28.

Published in final edited form as: Pediatr Res. 2021 May 28;91(6):1416–1427. doi: 10.1038/s41390-021-01584-6

Table 1. Physiological observations and blood gas results throughout the experiment.

		Normothermia		Hypothermia
		Mean	(SD)	Mean	(SD)
Weight (g)		2008	(132)	2075	(161)
Rectal Temp (°C)	Baseline	37.9	(0.8)	37.6	(0.4)
	4h LPS	38.6	(0.3)	38.6	(0.3)
	End of insult	38.1	(0.5)	38.1	(0.3)
	1-25h	38.4	(0.1)	34.0	(0.5)^**
	25-35h	38.7	(0.1)	36.5	(1.3)^**
	35-48h	38.4	(0.2)	38.2	(0.2)
Heart Rate (bpm)	Baseline	169.1	(26.0)	151.7	(11.9)
	4h LPS	192.9	(15.0)	185.0	(12.6)
	End of insult	237.3	(15.8)	225.6	(12.9)
	1-25h	234.9	(20.5)	170.9	(24.8)^**
	25-35h	210.0	(25.2)	180.0	(8.7)^*
	35-48h	185.2	(21.7)	173.0	(13.1)
MABP (mmHg)	Baseline	51.1	(4.3)	52.1	(1.4)
	4h LPS	53.1	(3.7)	54.1	(5.8)
	End of insult	47.3	(6.3)	43.7	(5.6)
	1-25h	45.7	(5.4)	42.7	(9.8)
	25-35h	55.0	(5.2)	42.8	(15.0)
	35-48h	49.5	(2.9)	54.8	(4.5)
pH	Baseline	7.48	(0.19)	7.57	(0.10)
	4h LPS	7.44	(0.10)	7.45	(0.07)
	End of insult	7.22	(0.11)	7.25	(0.13)
	12h	7.49	(0.07)	7.44	(0.17)
	24h	7.47	(0.03)	7.38	(0.13)
	48h	7.47	(0.04)	7.48	(0.05)
PaC02 (kPa)	Baseline	6.3	(3.4)	4.3	(0.8)
	4h LPS	5.8	(1.0)	5.6	(0.7)
	End of insult	6.3	(1.8)	5.6	(0.9)
	12h	5.3	(0.6)	4.4	(1.1)
	24h	5.4	(0.7)	5.1	(1.3)
	48h	5.2	(0.6)	5.0	(0.4)
PaO2 (kPa)	Baseline	18.6	(2.7)	15.0	(4.3)
	4h LPS	10.4	(1.1)	10.8	(0.9)
	End of insult	3.6	(0.4)	3.7	(0.9)
	12h	13.7	(4.8)	15.5	(6.6)
	24h	12.8	(3.1)	10.7	(4.0)
	48h	15.2	(3.9)	14.6	(1.8)
BE (mmol/L)	Baseline	8.5	(3.3)	7.7	(4.4)
	4h LPS	5.9	(3.4)	5.1	(3.4)
	End of insult	-9.0	(2.9)	-8.7	(4.9)
	12h	6.8	(3.4)	-0.3	(10.5)
	24h	5.7	(2.1)	-1.7	(9.8)
	48h	4.5	(2.4)	5.4	(4.9)
Lactate (mmol/L)	Baseline	3.6	(1.7)	2.9	(1.2)
	4h LPS	4.1	(2.0)	3.4	(1.3)
	End of insult	13.1	(1.7)	11.0	(2.2)
	12h	3.0	(0.6)	6.6	(5.0)
	24h	2.3	(0.8)	6.7	(7.1)
	48h	1.1	(0.2)	1.3	(0.3)
Glucose (mmol/L)	Baseline	4.9	(1.3)	5.2	(1.2)
	4h LPS	6.0	(2.2)	5.6	(0.5)
	End of insult	8.9	(3.0)	7.9	(1.0)
	12h	6.8	(1.2)	11.5	(5.6)
	24h	6.5	(1.2)	10.3	(3.6)^*
	48h	4.5	(1.2)	4.9	(0.7)
Potassium (mmol/L)	Baseline	4.1	(0.7)	4.5	(0.4)
	4h LPS	4.5	(0.4)	5.0	(0.4)
	End of insult	4.5	(0.5)	5.2	(0.8)
	12h	6.3	(0.7)	6.3	(1.0)
	24h	6.7	(0.7)	6.7	(1.4)
	48h	5.7	(1.2)	6.2	(1.3)

MABP mean arterial blood pressure, BE base excess

p<0.05

^**

p<0.005