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. Author manuscript; available in PMC: 2021 Oct 7.
Published in final edited form as: Genet Med. 2021 Jun 10;23(9):1726–1737. doi: 10.1038/s41436-021-01198-7

Figure 1. Association between the PRS and contralateral breast cancer risk for BRCA1 and BRCA2 heterozygotes.

Figure 1

The figure includes the effect size of the association between contralateral breast cancer and the three different PRS313 after testing for covariates for the following selections: all contralateral breast cancer, invasive contralateral breast cancer only, ER-negative contralateral breast cancer, and ER-positive contralateral breast cancer. The numbers of unilateral and contralateral breast cancer cases and effect sizes are shown in Table 2 and Table S4.

Abbreviations: CBC, Contralateral Breast Cancer; ER, Estrogen Receptor; HR, Hazard Ratio; PRS, Polygenic Risk Score; SD, Standard Deviation.