Table 1. Characteristics of risk scores used in the analysis, based on assessing risk at age 40.
Risk Score | Ma* | Jeon | MaJeon* | Huyghe | Total Risk | Total Risk plus Sex |
---|---|---|---|---|---|---|
Included risk factors | BMI Smoking Alcohol PA | 57 SNPs | BMI Smoking Alcohol PA 57 SNPs | 120 SNPs | BMI Smoking Alcohol PA 120 SNPs | BMI Smoking Alcohol PA 120 SNPs Sex |
10 year AUROC: Total | 0.559 | 0.577 | 0.660 | 0.678 | 0.720 | 0.721 |
10 year AUROC: Male | 0.566 | 0.572 | 0.654 | 0.673 | 0.715 | 0.715 |
10 year AUROC: Female | 0.546 | 0.582 | 0.666 | 0.684 | 0.723 | 0.723 |
Proportion who get CRC in top decile of risk | 0.145 | 0.157 | 0.242 | 0.250 | 0.314 | 0.316 |
Mean age at first FIT invite: with comparator age 60 | 60.06 | 60.11 | 60.50** | 60.08 | 60.05 | 60.10 |
Mean 10 year risk: with comparator age 60 | 0.96% | 0.98% | 0.94% | 0.90% | 0.90% | 0.86% |
Mean age at first FIT invite: with comparator age 50 | 50.13 | 50.10 | 50.07 | 50.02 | 50.04 | 50.06 |
Mean 10 year risk: with comparator age 50 | 0.34% | 0.34% | 0.29% | 0.32% | 0.31% | 0.30% |
BMI = Body Mass Index; PA = Physical Activity; SNP = Small nucleotide polymorphism; AUROC = Area Under the Receiver Operating Characteristic Curve; CRC = Colorectal Cancer; FIT = Faecal Immunochemical Test
The original Ma score also includes age, but this wasn’t included here as all individuals are being screened at age 40
The MaJeon age distribution is highly skewed compared to other scores meaning a risk level with a higher mean screening start age had to be selected to ensure a similar value for number of FIT invites per person.