Table 1. Characteristics of risk scores used in the analysis, based on assessing risk at age 40.

Risk Score	Ma*	Jeon	MaJeon*	Huyghe	Total Risk	Total Risk plus Sex
Included risk factors	BMI Smoking Alcohol PA	57 SNPs	BMI Smoking Alcohol PA 57 SNPs	120 SNPs	BMI Smoking Alcohol PA 120 SNPs	BMI Smoking Alcohol PA 120 SNPs Sex
10 year AUROC: Total	0.559	0.577	0.660	0.678	0.720	0.721
10 year AUROC: Male	0.566	0.572	0.654	0.673	0.715	0.715
10 year AUROC: Female	0.546	0.582	0.666	0.684	0.723	0.723
Proportion who get CRC in top decile of risk	0.145	0.157	0.242	0.250	0.314	0.316
Mean age at first FIT invite: with comparator age 60	60.06	60.11	60.50**	60.08	60.05	60.10
Mean 10 year risk: with comparator age 60	0.96%	0.98%	0.94%	0.90%	0.90%	0.86%
Mean age at first FIT invite: with comparator age 50	50.13	50.10	50.07	50.02	50.04	50.06
Mean 10 year risk: with comparator age 50	0.34%	0.34%	0.29%	0.32%	0.31%	0.30%

BMI = Body Mass Index; PA = Physical Activity; SNP = Small nucleotide polymorphism; AUROC = Area Under the Receiver Operating Characteristic Curve; CRC = Colorectal Cancer; FIT = Faecal Immunochemical Test

^*The original Ma score also includes age, but this wasn’t included here as all individuals are being screened at age 40

^**The MaJeon age distribution is highly skewed compared to other scores meaning a risk level with a higher mean screening start age had to be selected to ensure a similar value for number of FIT invites per person.