Table 2. Twenty-five shared genetic loci between lung function (FEV1, FVC) and obesity (BMI, WHRadjBMI, WCadjBMI) traits in CKB.
| Trait pair | Sentinel SNP | Clump region | N | A1 | A2 | BETA1 | P1 | BETA2 | P2 | P | Genes within clump region | Overlap with UKB |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FEV1 and BMI | rs73995038 | chr2:232797462-233165478 | 193 | A | G | -0.027 | 2.40E-09 | -0.024 | 1.30E-07 | 1.15E-15 | DIS3L2 | No |
| rs801170 | chr5:139973696-140230371 | 303 | C | T | 0.023 | 3.70E-07 | 0.022 | 7.20E-07 | 9.11E-13 | CD14,DND1,HARS,HARS2,IK,MIR3655,NDUFA2,PCDHA1,PCDHA2,PCDHA3,PCDHA4,PCDHA5,PCDHA6,PCDHA7,PCDHA8,PCDHA9,TMCO6, VTRNA1-1,VTRNA1-2,VTRNA1-3,WDR55,ZMAT2 | No | |
| rs9271730 | chr6:32397794-32667412 | 1728 | G | A | 0.022 | 3.10E-06 | 0.029 | 3.30E-10 | 7.72E-15 | HLA-DQA1,HLA-DQB1,HLA-DRA,HLA-DRB1,HLA-DRB5,HLA-DRB6 | No | |
| rs11066001 | chr12:111629389-112119171 | 19 | T | C | 0.024 | 7.60E-06 | 0.028 | 3.40E-07 | 1.99E-11 | ATXN2,BRAP,CUX2,FAM109A,MIR6760,SH2B3 | No | |
| rs144504271 | chr12:112140669-113117897 | 16 | G | A | 0.028 | 1.00E-06 | 0.029 | 3.20E-07 | 1.88E-12 | ACAD10,ADAM1A,ALDH2,ERP29,HECTD4,MAPKAPK5, MAPKAPK5-AS1,MIR6761,MIR6861,NAA25,PTPN11,RPL6,TMEM116,TRAFD1 | No | |
| rs2078863 | chr12:111846028-112355472 | 137 | T | C | 0.020 | 5.60E-06 | 0.020 | 9.50E-06 | 5.20E-10 | ACAD10,ADAM1A,ALDH2,ATXN2,BRAP,MAPKAPK5,MAPKAPK5-AS1,MIR6761,SH2B3 | No | |
| rs5742653 | chr12:102397730-102910374 | 339 | C | T | 0.021 | 4.50E-06 | 0.022 | 1.10E-06 | 2.03E-11 | CCDC53,IGF1,NUP37,PARPBP,PMCH | No | |
| FEV1 and WHRadjBMI | rs11066325 | chr12:112834586-113150735 | 7 | T | C | 0.036 | 2.00E-09 | 0.031 | 2.30E-07 | 5.44E-16 | PTPN11,RPL6 | No |
| rs3809297 | chr12:111293470-111718231 | 88 | G | T | 0.029 | 8.80E-07 | 0.026 | 6.80E-06 | 2.53E-11 | CCDC63,CUX2,LOC100131138,MYL2 | No | |
| rs4646776 | chr12:111886967-112678697 | 19 | G | C | 0.037 | 5.60E-11 | 0.029 | 2.20E-07 | 1.51E-17 | ACAD10,ADAM1A,ALDH2,ATXN2,BRAP,ERP29,HECTD4, MAPKAPK5,MAPKAPK5-AS1,MIR6761,MIR6861,NAA2 5,SH2B3,TMEM116,TRAFD1 | No | |
| rs7175531 | chr15:51415799-51556959 | 49 | T | C | 0.027 | 1.60E-07 | 0.022 | 7.80E-06 | 2.01E-12 | CYP19A1,MIR4713 | No | |
| rs6142351 | chr20:33864484-34336720 | 302 | G | A | -0.032 | 5.20E-11 | -0.024 | 1.20E-06 | 5.03E-16 | C20orf173,CEP250,CPNE1,EIF6,ERGIC3,FAM83C,FAM83C-AS1,FER1L4,GDF5,MMP24MMP24-AS1,NFS1,RBM12,RBM39,ROMO1,SPAG4,UQCC1 | Yes | |
| FEV1 and WCadjBMI | rs12048493 | chr1:149922960-149995265 | 4 | A | C | -0.023 | 1.00E-06 | 0.022 | 6.10E-06 | 1.92E-10 | OTUD7B | Yes |
| rs6604614 | chr1:218568359-218690948 | 71 | C | G | -0.030 | 5.10E-09 | -0.027 | 1.90E-07 | 1.06E-16 | TGFB2 | Yes | |
| rs16828537 | chr2:232797462-233211117 | 264 | A | G | 0.033 | 3.90E-13 | -0.025 | 3.30E-08 | 3.91E-19 | DIS3L2 | No | |
| rs11066065 | chr12:111846028-112824473 | 707 | C | G | 0.025 | 2.20E-08 | 0.024 | 1.20E-07 | 1.92E-16 | ACAD10,ADAM1A,ALDH2,A TXN2,BRAP,ERP29,HECTD4, MAPKAPK5,MAPKAPK5-AS1,MIR6761,MIR6861,NAA2 5,SH2B3,TMEM116,TRAFD1 | No | |
| rs11066325 | chr12:112834586-113150735 | 7 | T | C | 0.053 | 6.70E-19 | 0.031 | 2.30E-07 | 5.08E-27 | PTPN11,RPL6 | No | |
| rs4646776 | chr12:111827203-112678697 | 31 | G | C | 0.055 | 4.90E-23 | 0.029 | 2.20E-07 | 7.56E-31 | ACAD10,ADAM1A,ALDH2,ATXN2,BRAP,ERP29,HECTD4, MAPKAPK5,MAPKAPK5-AS1,MIR6761,MIR6861,NAA2 5,SH2B3,TMEM116,TRAFD1 | No | |
| rs78572043 | chr12:111293470-111718231 | 94 | A | G | 0.046 | 1.10E-13 | 0.029 | 2.70E-06 | 4.58E-20 | CCDC63,CUX2,LOC100131138,MYL2 | No | |
| FVC and BMI | rs6730783 | chr2:219890663-220051676 | 63 | A | G | -0.023 | 2.00E-07 | -0.021 | 4.00E-06 | 2.73E-12 | CCDC108,CNPPD1,FAM134A,IHH,MIR3131,NHEJ1,SLC23A3 | No |
| rs73995038 | chr2:232797462-233201328 | 207 | A | G | -0.027 | 2.40E-09 | -0.024 | 7.10E-08 | 4.13E-16 | DIS3L2 | No | |
| rs801170 | chr5:139791506-140230371 | 327 | C | T | 0.023 | 3.70E-07 | 0.022 | 1.30E-06 | 8.74E-13 | ANKHD1,ANKHD1-EIF4EBP3,APBB3,CD14,DND1,EIF4EBP3,HARS,HARS2,I K,MIR3655,MIR6831,NDUFA2,PCDHA1,PCDHA2,PCDHA3, PCDHA4,PCDHA5,PCDHA 6,PCDHA7,PCDHA8,PCDHA 9,SLC35A4,SRA1,TMCO6,VT RNA1-1,VTRNA1-2,VTRNA1-3,WDR55,ZMAT2 | No | |
| rs9271730 | chr6:32397794-32667412 | 2271 | G | A | 0.022 | 3.10E-06 | 0.028 | 1.30E-09 | 2.21E-14 | HLA-DQA1,HLA-DQB1,HLA-DRA,HLA-DRB1,HLA-DRB5,HLA-DRB6 | No | |
| FVC and WHRadjBMI | rs2425059 | chr20:33847253-34412049 | 326 | T | C | 0.033 | 3.70E-11 | 0.022 | 9.10E-06 | 1.61E-14 | C20orf173,CEP250,CPNE1,EIF6,ERGIC3,FAM83C,FAM83C-AS1,FER1L4,GDF5,MMP24,MMP24-AS1,NFS1,PHF20,RBM12,RBM39,ROMO1,SPAG4, UQCC1 | Yes |
| FVC and WCadjBMI | rs16828537 | chr2:232797462-233211117 | 257 | A | G | 0.033 | 3.90E-13 | -0.025 | 1.40E-08 | 5.78E-17 | DIS3L2 | Yes |
Note: N is number of variants meet the criteria of P-value<1×10-5 and r2>0.2 within the clump region; A1 is effect allele; A2 is non-effect allele; BETA1 is lung function trait effect size; P1 is lung function trait P-value; BETA2 is obesity trait effect size; P2 is obesity trait P-value; P is cross-trait meta-analysis P-value. Overlap with UKB means if the cross-trait meta-analysis clump region is overlapped with the same trait pair results in UKB.