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. Author manuscript; available in PMC: 2021 Jul 23.
Published in final edited form as: Mol Aspects Med. 2021 Jul 23;81:101004. doi: 10.1016/j.mam.2021.101004

Fig. 3. ER Ca2+ homeostasis and viral infections.

Fig. 3

A number of viruses target ER Ca2+ handling toolkit, which in turn aids in all three stages of infection i.e. viral entry (eg. HSV), viral replication (eg. HIV and HBV) and viral exit (eg. HIV). Some viruses, such as RV and HCMV can induce ER Ca2+ efflux by forming viroporin in the ER membrane. This in turn helps in viral replication and assembly. While oncogenic EBV targets SERCA regulated ER Ca2+ homeostasis for driving viral infection and associated oncogenesis.