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. Author manuscript; available in PMC: 2021 Jul 23.
Published in final edited form as: Mol Aspects Med. 2021 Jul 23;81:101004. doi: 10.1016/j.mam.2021.101004

Fig. 5. Lysosomal Ca2+ dynamics and viral entry.

Fig. 5

A variety of viruses target lysosomal Ca2+ efflux channels for host cell entry via endocytic route. Viruses such as EBOV, Marburg virus, Polyoma virus and MERS-CoV target TPCs for facilitating receptor mediated entry into host cells. Importantly, TPCs also regulate SARS-CoV-2 entry into host cells. While TRPML1 regulates HIV-1 replication and latent infection.