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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Int J Obes (Lond). 2021 Oct 29;46(2):333–341. doi: 10.1038/s41366-021-01005-y

Figure 1. Differential miRNA expression in obese individuals before RYGB compared with non-obese Controls, identified by NGS.

Figure 1

(A) Volcano plot illustrating 43 significantly upregulated miRNAs (red dots, top 5 miRNAs are annotated: miR-31-5p, miR-215-3p, miR-215- 5p, miR-30a-5p and miR-204-5p) and 39 downregulated miRNAs (blue dots, top 5 are annotated: miR-1273f, miR-200b-5p, miR-1247-5p, miR-552-5p and miR-1247-3p) with fold change >1 (B) Heatmap of significantly up-regulated miRNAs, for which expression differed significantly between the obese individuals pre-RYGB and the non-obese Controls. (C) Heatmap of significantly downregulated miRNAs, for which expression differed significantly between the obese individuals pre-RYGB and the non-obese Controls. (D) IPA network of miRNAs for which expression differed by logFC>1 in the obese pre-RYGB and non-obese Controls and their predicted target molecules.