Table 3. Enrolment time of patients according to consent pathways.

	All	Two-stage doctor	Two-stage patient	Two-stage relative	One-stage patient	One-stage relative	P
Onset-to-CT time (minutes)	115 [81, 171]	99 [70, 150]	117 [80, 173]	119 [85, 175]	119 [85, 182]	116 [80, 168]	0.003
CT-to-randomisation (minutes)	75 [47, 128]	55 [38, 93]	55 [37, 95]	69 [43, 110]	75 [48,124]	90 [56, 155]	<0.001
Randomisation to first dose of IMP (minutes)	20 [12, 31]	17 [10, 28]	18 [11, 28]	19 [11, 28]	18 [11, 30]	22 [13, 36]	0.614
Onset-to-randomisation (mean, SD, minutes)	237 (102)	195 (89)	215 (98)	225 (91)	238 (108)	253 (103)	<0.001
Onset-to-randomisation (median, IQR, minutes)	217 [155, 302]	174 [122, 236]	193 [142, 270]	211 [156, 278]	222 [155, 305]	236 [167, 332]	<0.001
≤60 minutes	2 (0.1%)	2 (1.1%)	0	0	0	0	-
≤120 minutes	232 (10.0%)	40 (21.3%)	41 (15.8%)	35 (10.8%)	59 (10.6%)	57 (5.7%)	<0.001
≤180 minute	833 (35.8%)	100 (53.2%)	114 (43.8%)	129 (39.9%)	186 (33.4%)	303 (30.4%)	<0.001
Onset to first dose of IMP (minutes)	244 [180, 330]	200 [149, 259]	215 [163, 299]	229 [175, 304]	247 [180, 330]	267 [193, 364]	<0.001

Data are n (%), median [IQR, interquartile range] or mean (SD, standard deviation). Analyses are Chi-squared test for categorical variables and Kruskal-Wallis test for median or one-way ANOVA for mean comparison.