Table 4. Multivariable logistic regression of factors associated with time-to-randomisation of ≤3 hours.

Variables	Model 1, aOR (95%CI)	P	Model 2, aOR (95%CI)	P	Model 3, aOR (95%CI)	P
Age (years)	1.01 (0.99-1.01)	0.26	1.01 (0.99-1.02)	0.25	1.00 (0.98-1.01)	0.55
Sex (male)	1.23 (0.98-1.54)	0.074	1.22 (0.94-1.59)	0.14	1.11 (0.88-1.40)	0.39
Systolic BP (mmHg)	1.01 (1.00-1.01)	0.001	1.01 (1.00-1.01)	<0.001	1.01 (1.00-1.01)	0.001
NIHSS (/42)	1.02 (1.00-1.03)	0.046	1.02 (1.00-1.04)	0.050	1.04 (1.02-1.06)	<0.001
Onset-to-CT time (minutes)	0.97 (0.96-0.97)	<0.001	0.97 (0.96-0.97)	<0.001	0.97 (0.96-0.97)	<0.001
Recruitment from UK	2.68 (1.97-3.65)	<0.001	3.10 (2.24-4.31)	<0.001	3.29 (2.37-4.58)	<0.001
Consent type*
2-stage vs 1-stage (reference)	1.89 (1.49-2.39)	<0.001	-		-	-
Doctor vs Self (reference)	-	-	2.29 (1.52-3.47)	<0.001	-	-
Relative vs Self (reference)	-	-	-	-	0.10 (0.03-0.34)	<0.001

aOR=adjusted odds ratio; NIHSS=National Institutes of Health Stroke Scale.

^*3 different models used as there was overlap of consent types: one-stage consent includes one-stage patient and relative consent; two-stage consents include two-stage patient, relative and doctor consent; relative consent includes one- and two-stage relative consent; self-consent includes one- and two-stage patient consent.