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. Author manuscript; available in PMC: 2022 Feb 15.
Published in final edited form as: Nat Genet. 2022 Feb 10;54(2):128–133. doi: 10.1038/s41588-021-01005-8

Figure 1. Possible violations of the infinite sites assumption in a single clonal lineage.

Figure 1

Two subsequent mutations at a diploid locus can affect the same or alternate alleles. Depending on the base changes, there are four scenarios: biallelic parallel or divergent mutations affect separate alleles, whereas monoallelic forward and back mutation hit the same allele twice.