Table 1. MS and inflammatory measures within the CSA-cohort (A) and patients who progressed to RA (B).
| (A) Complete cohort (n=575) OR (95%CI) | (B) RA-subgroup (n=76) OR (95%CI) | |
|---|---|---|
| Univariable: | ||
| Increased CRP | 1.93 (1.30-2.88) | 3.86 (1.45-10.24) |
| Any subclinical inflammation + | 1.34 (0.95-1.89) | 5.00 (0.99-24.41) |
| Subclinical synovitis + | 1.95 (1.32-2.87) | 2.56 (1.04-6.52) |
| Subclinical tenosynovitis + | 1.59 (1.10-2.31) | 3.09 (0.99-9.60) |
| Subclinical osteitis + | 1.14 (0.76-1.72) | 1.50 (0.59-3.84) |
| Multivariable #: | ||
| Increased CRP | 1.78 (1.17-2.69) | 3.24 (1.13-9.25) |
| Subclinical synovitis + | 1.77 (1.16-2.69) | 2.07 (0.73-5.87) |
| Subclinical tenosynovitis + | 1.13 (0.75-1.72) | 1.47 (0.40-5.49) |
| Multivariable *: | ||
| Increased CRP | 1.79 (1.18-2.72) | 10.57 (2.27-49.17) |
| Subclinical synovitis + | 1.69 (1.10-2.58) | 1.63 (0.52-5.09) |
| Subclinical tenosynovitis + | 1.23 (0.80-1.91) | 1.76 (0.42-7.35) |
Increased CRP: C-reactive protein (increased if ≥5 mg/L), +: presence of an MRI-feature, ACPA: anti-citrullinated peptide antibody (anti-CCP2, positive if ≥7U/mL), 95% CI: 95% confidence interval
#
Independent variables: increased CRP, subclinical synovitis + and subclinical tenosynovitis +.
*
Independent variables: increased CRP, subclinical synovitis + and subclinical tenosynovitis +, age and gender.
Explained variance (Nagelkerke R2) of the multivariable model (#) in the complete cohort was 5% and increased to 18% in the RA-subgroup.