Table 2. Estimates of the association between CHD and CHD risk factors and genetically determined reproductive aging.

	CHD beta (95% CI)	Total cholesterol beta (95% CI)	LDL cholesterol beta (95% CI)	Systolic blood pressure beta (95% CI)	Diastolic blood pressure beta (95% CI)	Body mass index beta (95% CI)
Simple median	0.064 (-0.104 to 0.232)	0.000 (-0.005 to 0.005)	0.004 (-0.002 to 0.009)	-0.006 (-0.030 to 0.019)	0.018 (-0.022 to 0.058)	-0.385 (-0.658 to -0.112)
Weighted median	0.057 (-0.100 to 0.231)	-0.005 (-0.009 to 0.001)	0.000 (-0.004 to 0.004)	-0.013 (-0.036 to 0.009)	-0.008 (-0.043 to 0.028)	-0.114 (-0.379 to 0.151)
IVW	0.063 (-0.050 to 0.176)	-0.002 (-0.006 to 0.002)	0.003 (-0.001 to 0.006)	0.015 (-0.018 to 0.049)	0.023 (-0.031 to 0.077)	-0.069 (-0.294 to 0.156)
MR-Egger	-0.005 (-0.260 to 0.251)	-0.007 (-0.013 to 0.000)	0.001 (-0.005 to 0.008)	-0.004 (-0.112 to 0.104)	-0.060 (-0.237 to 0.117)	0.418 (-0.116 to 0.953)

We used the sex-combined genome-wide association study summary statistics for the exposure because sex-specific summary statistics were not available. The outcome at natural menopause is only available in women, so the outcome variants are in women only.

Abbreviations: CHD, coronary heart disease; IVW, inverse-variance weighted; MR, Mendelian randomization; LDL, low-density lipoprotein.