| Ligand | Bias plot slope | G protein | Arrestin | Ligand bias | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Emax (%)* |
EC50 (nM) |
Log (Emax/EC50) |
ΔLog (Emax/EC50) |
Emax (%)* |
EC50 (nM) |
Log (Emax/EC50) |
ΔLog (Emax/EC50) |
ΔΔLog (Emax/EC50) |
Bias factor | For | ||
| Salvinorin A | 1.0 | 99.7 | 5.18 | 8.3 | 0.0 (ref.) | 97.2 | 5.75 | 8.2 | 0.0 (ref.) | 0.0 | 1.0 | - (ref.) |
| GR 89696 | 0.6 | 96.4 | 0.97 | 9.0 | 0.7 | 92.8 | 0.26 | 9.6 | 1.3 | 0.6 | 3.6 | Arrestin |
| ICI 199,441 | 0.7 | 101 | 1.63 | 8.8 | 0.5 | 84.8 | 0.4 | 9.3 | 1.0 | 0.5 | 3.2 | Arrestin |
| RB 48 | 1.8 | 101 | 8.82 | 8.1 | -0.2 | 63.2 | 143 | 6.6 | -1.6 | 1.4 | 26 | G protein |
| RB 64 | 1.3 | 101 | 5.29 | 8.3 | 0.0 | 104 | 391 | 6.4 | -1.9 | 1.9 | 72 | G protein |
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