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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Proc Natl Acad Sci U S A. 2022 Jun 21;119(26):e2204084119. doi: 10.1073/pnas.2204084119

Figure 2. Auditory studies in Minar2 mutant mice.

Figure 2

(A-C) Auditory Brainstem Response (ABR) thresholds. Mean (±SD) ABR thresholds are plotted against stimulus for Minar2+/+ mice (teal down-triangles) and Minar2tm1b/tm1b mice (red up-triangles). Open grey circles indicate thresholds for individual Minar2tm1b/tm1b mice. Results are plotted for data obtained at P14 (A) (n=4 Minar2+/+, 9 Minar2tm1b/tm1b); P21. (B) (n=11 Minar2+/+, 12 Minar2tm1b/tm1b and P27-28 (C) (n=10 Minar2+/+, 11 Minar2tm1b/tm1b). Ck, click. (D-E) Distortion Product OtoAcoustic Emission (DPOAE) thresholds. Mean (±SD) DPOAE thresholds are plotted against f2 stimulus frequency for Minar2 control mice (teal down-triangles) and Minar2tm1b/tm1b mice (red up-triangles). Open grey circles indicate thresholds for individual Minar2tm1b/tm1b mice. Results are plotted for data obtained at P14 (D) (n=4 controls, comprising 1 wildtype and 3 heterozygotes, n=4 mutants) and P27-28 (E) (n=4 wildtypes, n=6 mutants). (F, G) Endocochlear Potential (EP) in Minar2 mutant mice aged 4 weeks (F) and 14 weeks old (G). Colored circles indicate the mean (±SD) EP measurement in Minar2+/+ (teal), Minar2+/tm1b (cyan) Minar2tm1b/tm1b (red) mice. Open grey circles indicate the EP values recorded in individual mice. At 4 weeks old (P30-32) Minar2+/+ n=5, range 101.2 – 127.8 mV; Minar2+/tm1b n=2 range 117.0 – 125.4 mV; Minar2tm1b/tm1b n=9, range 93.4 – 120.5 mV. At 14 weeks old Minar2+/+ n=4, range 117 – 133.6 mV; Minar2+/tm1b n=7, range 113.8 – 131.6 mV; Minar2tm1b/tm1b n=8, range 103.5 – 124.7 mV.