Table 3. Associations of mutually adjusted CMR metrics with incident cardiovascular disease and mortality outcomes in Cox proportional hazard models with full confounder adjustment.
| CMR metric | AF | Stroke | IHD | MI | All-cause mortality | CVD mortality |
|---|---|---|---|---|---|---|
| LAVi (mL/m2) | 1.47* (1.28–1.70) 8.46 x 10-8 |
1.13 (0.98-1.31) 0.0807 |
1.10 (1.01-1.19) 0.0302 |
1.06 (0.93-1.21) 0.4002 |
1.11 (1.00-1.23) 0.0407 |
1.34* (1.05–1.71) 0.0185 |
| LAEF (%) | 0.64* (0.56–0.73) 2.50 x10-11 |
0.83* (0.73–0.95) 0.0060 |
0.88* (0.81–0.95) 9.95 x10-4 |
0.87* (0.76–0.99) 0.0294 |
0.96 (0.87–1.06) 0.4029 |
0.85 (0.69–1.04) 0.1119 |
| LVM: LVEDV | 1.06 (0.92–1.23) 0.4036 |
1.22* (1.06–1.40) 0.0065 |
1.27* (1.17–1.37) 1.27x10-8 |
1.14 (0.99–1.30) 0.0732 |
1.09 (0.98–1.22) 0.0959 |
1.05 (0.82–1.35) 0.7039 |
| LVGFI (%) | 0.92 (0.79–1.06) 0.2521 |
0.89 (0.76–1.03) 0.1266 |
0.88* (0.80–0.96) 0.0063 |
0.95 (0.82–1.11) 0.5372 |
0.85* (0.76–0.95) 0.0050 |
0.61* (0.48–0.78) 5.95 x10-5 |
| GLS (%) | 0.97 (0.85–1.12) 0.7171 |
1.10 (0.95–1.27) 0.1880 |
1.08 (0.99–1.17) 0.0888 |
1.05 (0.91–1.20) 0.5254 |
1.14* (1.02–1.27) 0.0170 |
1.10 (0.87–1.38) 0.4314 |
Results are hazard ratios, 95% confidence intervals, and P-values. Covariates are LAV, LAEF, LVM/LVEDV, GLS, GLFI, age, sex, ethnicity, deprivation, education, body mass index, hypertension, high cholesterol, diabetes, physical activity, and smoking. The CMR variables are principal component analysis rotated variables.
AF, atrial fibrillation; CMR, cardiovascular magnetic resonance; CVD, cardiovascular disease; LVGFI, left ventricular global function index; GLS, global longitudinal strain; i, indicates indexation to body surface area; IHD, ischaemic heart disease; LAEF, left atrial ejection fraction; LAV, maximum left atrial volume; LVEDV, left ventricular end-diastolic volume; LVM, left ventricular mass; MI, myocardial infarction.
Statistically significant P-values with a false discovery rate of 0.05, giving an approximate threshold of 0.028.