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. Author manuscript; available in PMC: 2022 Aug 26.
Published in final edited form as: Cell Mol Life Sci. 2018 Aug 10;75(21):3895–3905. doi: 10.1007/s00018-018-2892-y

Fig. 1. Model of the functional role of NTCP in hepatic bile acid transport and metabolism.

Fig. 1

Transport of bile acids from portal blood into hepatocytes via NTCP depends on a sodium gradient and is inhibited by CsA or ezetimibe. Secretion into the bile canaliculus via bile salt export pump (BSEP) in an ATP-dependent manner and synthesis from cholesterol are regulated by bile acid-mediated activation of FXR. cAMP mediates dephosphorylation and membrane translocation of NTCP. NTCP: Sodium taurocholate co-transporting polypeptide; BSEP: bile salt export pump; FXR: Farnesoid X Receptor; SHP: small heterodimer partner; CYP7A1: cholesterol 7α-hydroxylase; BA: bile acid; TJ: tight junction; CsA: cyclosporin A; cAMP: cyclic adenosine monophosphate