Table 2. Risk of new-onset DM by carotid-femoral CF-PWV in the FHS.

	Unadjusted	Model 1*	Model 2†	Model 3‡	Model 4§
	sHR (95% CI, P-value)	sHR (95% CI, P-value)	sHR (95% CI, P-value)	sHR (95% CI, P-value)	sHR (95% CI, P-value)
CF-PWV	1.56 (1.35-1.80, P=1.1x10-9)	1.78 (1.41-2.23, P=7.4x10-7)	1.56 (1.19-2.03, P=0.001)	1.47 (1.12-1.93, P=0.006)	1.36 (1.03-1.76, P=0.030)
Brachial pulse pressure	1.24 (1.12-1.38, P=3.7x10-5)	1.28 (1.11-1.47, P=0.001)	1.17 (0.98-1.39, P=0.082)	1.15 (0.97-1.38, P=0.108)	1.18 (0.98-1.41, P=0.075)
Central pulse pressure	1.31 (1.22-1.41, P=1.6x10-13)	1.37 (1.19-1.57, P=1.3x10-5)	1.31 (1.12-1.52, P=0.001)	1.28 (1.10-1.50, P=0.001)	1.26 (1.08-1.48, P=0.004)

Abbreviations: CF-PWV = carotid-femoral pulse wave velocity; CI = confidence interval; FHS = Framingham Heart Study; sHR = standardized hazard ratio (calculated using Cox regression, determined for each standard deviation increase in CF-PWV)

^*Model 1: Adjusted for age, sex, and BMI

^†Model 2: Adjusted for Model 1 + MAP + HR

^‡Model 3: Adjusted for Model 2 + eGFR

^§Model 4: Adjusted for Model 3 + smoking + total cholesterol + high density lipoprotein + thiazide diuretic + beta-blocker + total antihypertensive medications + c-reactive protein + family history of DM